                         SEQUENCE LISTING

<110>  Novo Nordisk A/S
 
<120>  Tolerogenic DNA vaccine

<130>  150042WO01

<150>  US 62/415717
<151>  2016-11-01

<150>  EP 17150037.4
<151>  2017-01-02

<150>  EP 17169019.1
<151>  2017-05-02

<150>  EP 17177289.0
<151>  2017-06-22

<150>  EP 17198041.0
<151>  2017-10-24

<160>  29    

<170>  PatentIn version 3.5

<210>  1
<211>  86
<212>  PRT
<213>  mus musculus

<400>  1

Phe Val Asn Gln His Leu Cys Gly Ser His Leu Val Glu Ala Leu Tyr 
1               5                   10                  15      


Leu Val Cys Gly Glu Arg Gly Phe Phe Tyr Thr Pro Lys Thr Arg Arg 
            20                  25                  30          


Glu Ala Glu Asp Leu Gln Val Gly Gln Val Glu Leu Gly Gly Gly Pro 
        35                  40                  45              


Gly Ala Gly Ser Leu Gln Pro Leu Ala Leu Glu Gly Ser Leu Gln Lys 
    50                  55                  60                  


Arg Gly Ile Val Glu Gln Cys Cys Thr Ser Ile Cys Ser Leu Tyr Gln 
65                  70                  75                  80  


Leu Glu Asn Tyr Cys Asn 
                85      


<210>  2
<211>  86
<212>  PRT
<213>  homo sapiens

<400>  2

Phe Val Asn Gln His Leu Cys Gly Ser His Leu Val Glu Ala Leu Tyr 
1               5                   10                  15      


Leu Val Cys Gly Glu Arg Gly Phe Phe Tyr Thr Pro Lys Thr Arg Arg 
            20                  25                  30          


Glu Ala Glu Asp Leu Gln Val Gly Gln Val Glu Leu Gly Gly Gly Pro 
        35                  40                  45              


Gly Ala Gly Ser Leu Gln Pro Leu Ala Leu Glu Gly Ser Leu Gln Lys 
    50                  55                  60                  


Arg Gly Ile Val Glu Gln Cys Cys Thr Ser Ile Cys Ser Leu Tyr Gln 
65                  70                  75                  80  


Leu Glu Asn Tyr Cys Asn 
                85      


<210>  3
<211>  110
<212>  PRT
<213>  synthetic

<400>  3

Met Ala Leu Trp Met Arg Leu Leu Pro Leu Leu Ala Leu Leu Ala Leu 
1               5                   10                  15      


Trp Gly Pro Asp Pro Glu Gln Glu Phe Val Asn Gln His Leu Cys Gly 
            20                  25                  30          


Ser His Leu Val Glu Ala Leu Tyr Leu Val Cys Gly Glu Arg Gly Phe 
        35                  40                  45              


Phe Tyr Thr Pro Lys Thr Arg Arg Glu Ala Glu Asp Leu Gln Val Gly 
    50                  55                  60                  


Gln Val Glu Leu Gly Gly Gly Pro Gly Ala Gly Ser Leu Gln Pro Leu 
65                  70                  75                  80  


Ala Leu Glu Gly Ser Leu Gln Lys Arg Gly Ile Val Glu Gln Cys Cys 
                85                  90                  95      


Thr Ser Ile Cys Ser Leu Tyr Gln Leu Glu Asn Tyr Cys Asn 
            100                 105                 110 


<210>  4
<211>  110
<212>  PRT
<213>  synthetic

<400>  4

Met Ala Leu Trp Met Arg Leu Leu Pro Leu Leu Ala Leu Leu Ala Leu 
1               5                   10                  15      


Trp Gly Pro Asp Pro Glu Gln Glu Phe Val Asn Gln His Leu Cys Gly 
            20                  25                  30          


Ser His Leu Val Glu Ala Leu Tyr Leu Val Cys Gly Glu Arg Gly Phe 
        35                  40                  45              


Phe Tyr Thr Pro Lys Thr Arg Arg Glu Ala Glu Asp Leu Gln Val Gly 
    50                  55                  60                  


Gln Val Glu Leu Gly Gly Gly Pro Gly Ala Gly Ser Leu Gln Pro Leu 
65                  70                  75                  80  


Ala Leu Glu Gly Ser Leu Gln Lys Arg Gly Ile Val Glu Gln Cys Cys 
                85                  90                  95      


Thr Ser Ile Cys Ser Leu Tyr Gln Leu Glu Asn Tyr Cys Asn 
            100                 105                 110 


<210>  5
<211>  109
<212>  PRT
<213>  mus musculus

<400>  5

Ala Leu Trp Met Arg Leu Leu Pro Leu Leu Ala Leu Leu Ala Leu Trp 
1               5                   10                  15      


Gly Pro Asp Pro Ala Gln Ala Phe Val Asn Gln His Leu Cys Gly Ser 
            20                  25                  30          


His Leu Val Glu Ala Leu Tyr Leu Val Cys Gly Glu Arg Gly Phe Phe 
        35                  40                  45              


Tyr Thr Pro Lys Thr Arg Arg Glu Ala Glu Asp Leu Gln Val Gly Gln 
    50                  55                  60                  


Val Glu Leu Gly Gly Gly Pro Gly Ala Gly Ser Leu Gln Pro Leu Ala 
65                  70                  75                  80  


Leu Glu Gly Ser Leu Gln Lys Arg Gly Ile Val Glu Gln Cys Cys Thr 
                85                  90                  95      


Ser Ile Cys Ser Leu Tyr Gln Leu Glu Asn Tyr Cys Asn 
            100                 105                 


<210>  6
<211>  110
<212>  PRT
<213>  homo sapiens

<400>  6

Met Ala Leu Trp Met Arg Leu Leu Pro Leu Leu Ala Leu Leu Ala Leu 
1               5                   10                  15      


Trp Gly Pro Asp Pro Ala Gln Ala Phe Val Asn Gln His Leu Cys Gly 
            20                  25                  30          


Ser His Leu Val Glu Ala Leu Tyr Leu Val Cys Gly Glu Arg Gly Phe 
        35                  40                  45              


Phe Tyr Thr Pro Lys Thr Arg Arg Glu Ala Glu Asp Leu Gln Val Gly 
    50                  55                  60                  


Gln Val Glu Leu Gly Gly Gly Pro Gly Ala Gly Ser Leu Gln Pro Leu 
65                  70                  75                  80  


Ala Leu Glu Gly Ser Leu Gln Lys Arg Gly Ile Val Glu Gln Cys Cys 
                85                  90                  95      


Thr Ser Ile Cys Ser Leu Tyr Gln Leu Glu Asn Tyr Cys Asn 
            100                 105                 110 


<210>  7
<211>  15
<212>  PRT
<213>  homo sapiens

<400>  7

Ser His Leu Val Glu Ala Leu Tyr Leu Val Cys Gly Glu Arg Gly 
1               5                   10                  15  


<210>  8
<211>  15
<212>  PRT
<213>  synthetic

<400>  8

Ser His Leu Val Glu Ala Leu Tyr Leu Val Cys Gly Glu Glu Gly 
1               5                   10                  15  


<210>  9
<211>  81
<212>  PRT
<213>  mus musculus

<400>  9

Met Asp Asp Gln Arg Asp Leu Ile Ser Asn His Glu Gln Leu Pro Ile 
1               5                   10                  15      


Leu Gly Asn Arg Pro Arg Glu Pro Glu Arg Cys Ser Arg Gly Ala Leu 
            20                  25                  30          


Tyr Thr Gly Val Ser Val Leu Val Ala Leu Leu Leu Ala Gly Gln Ala 
        35                  40                  45              


Thr Thr Ala Tyr Phe Leu Tyr Gln Gln Gln Gly Arg Leu Asp Lys Leu 
    50                  55                  60                  


Thr Ile Thr Ser Gln Asn Leu Gln Leu Glu Ser Leu Arg Met Lys Leu 
65                  70                  75                  80  


Pro 
    


<210>  10
<211>  98
<212>  PRT
<213>  homo sapiens

<400>  10

Met His Arg Arg Arg Ser Arg Ser Cys Arg Glu Asp Gln Lys Pro Val 
1               5                   10                  15      


Met Asp Asp Gln Arg Asp Leu Ile Ser Asn Asn Glu Gln Leu Pro Met 
            20                  25                  30          


Leu Gly Arg Arg Pro Gly Ala Pro Glu Ser Lys Cys Ser Arg Gly Ala 
        35                  40                  45              


Leu Tyr Thr Gly Phe Ser Ile Leu Val Thr Leu Leu Leu Ala Gly Gln 
    50                  55                  60                  


Ala Thr Thr Ala Tyr Phe Leu Tyr Gln Gln Gln Gly Arg Leu Asp Lys 
65                  70                  75                  80  


Leu Thr Ile Thr Ser Gln Asn Leu Gln Leu Glu Ser Leu Arg Met Lys 
                85                  90                  95      


Leu Pro 
        


<210>  11
<211>  219
<212>  DNA
<213>  E. coli

<400>  11
atggccaaag aagacaatat tgaaatgcaa ggtaccgttc ttgaaacgtt gcctaatacc       60

atgttccgcg tagagttaga aaacggtcac gtggttactg cacacatctc cggtaaaatg      120

cgcaaaaact acatccgcat cctgacgggc gacaaagtga ctgttgaact gaccccgtac      180

gacctgagca aaggccgcat tgtcttccgt agtcgctga                             219


<210>  12
<211>  72
<212>  PRT
<213>  E. coli

<400>  12

Met Ala Lys Glu Asp Asn Ile Glu Met Gln Gly Thr Val Leu Glu Thr 
1               5                   10                  15      


Leu Pro Asn Thr Met Phe Arg Val Glu Leu Glu Asn Gly His Val Val 
            20                  25                  30          


Thr Ala His Ile Ser Gly Lys Met Arg Lys Asn Tyr Ile Arg Ile Leu 
        35                  40                  45              


Thr Gly Asp Lys Val Thr Val Glu Leu Thr Pro Tyr Asp Leu Ser Lys 
    50                  55                  60                  


Gly Arg Ile Val Phe Arg Ser Arg 
65                  70          


<210>  13
<211>  127
<212>  DNA
<213>  L. monocytogenes

<400>  13
tgtaaaaaac atcatttagc gtgactttct ttcaacagct aacaattgtt gttactgcct       60

aatgttttta gggtatttta aaaaagggcg ataaaaaacg attgggggat gagaaatgaa      120

cgctcaa                                                                127


<210>  14
<211>  10
<212>  DNA
<213>  synthetic

<400>  14
gccrccatgg                                                              10


<210>  15
<211>  24
<212>  PRT
<213>  synthetic

<400>  15

Ala Pro Val Lys Gln Thr Leu Asn Phe Asp Leu Leu Lys Leu Ala Gly 
1               5                   10                  15      


Asp Val Glu Ser Asn Pro Gly Pro 
            20                  


<210>  16
<211>  20
<212>  PRT
<213>  Thosea asigna

<400>  16

Arg Ala Glu Gly Arg Gly Ser Leu Leu Thr Cys Gly Asp Val Glu Glu 
1               5                   10                  15      


Asn Pro Gly Pro 
            20  


<210>  17
<211>  19
<212>  PRT
<213>  synthetic

<400>  17

Ala Thr Asn Phe Ser Leu Leu Lys Gln Ala Gly Asp Val Glu Glu Asn 
1               5                   10                  15      


Pro Gly Pro 
            


<210>  18
<211>  390
<212>  PRT
<213>  homo sapiens

<400>  18

Met Pro Pro Ser Gly Leu Arg Leu Leu Leu Leu Leu Leu Pro Leu Leu 
1               5                   10                  15      


Trp Leu Leu Val Leu Thr Pro Gly Arg Pro Ala Ala Gly Leu Ser Thr 
            20                  25                  30          


Cys Lys Thr Ile Asp Met Glu Leu Val Lys Arg Lys Arg Ile Glu Ala 
        35                  40                  45              


Ile Arg Gly Gln Ile Leu Ser Lys Leu Arg Leu Ala Ser Pro Pro Ser 
    50                  55                  60                  


Gln Gly Glu Val Pro Pro Gly Pro Leu Pro Glu Ala Val Leu Ala Leu 
65                  70                  75                  80  


Tyr Asn Ser Thr Arg Asp Arg Val Ala Gly Glu Ser Ala Glu Pro Glu 
                85                  90                  95      


Pro Glu Pro Glu Ala Asp Tyr Tyr Ala Lys Glu Val Thr Arg Val Leu 
            100                 105                 110         


Met Val Glu Thr His Asn Glu Ile Tyr Asp Lys Phe Lys Gln Ser Thr 
        115                 120                 125             


His Ser Ile Tyr Met Phe Phe Asn Thr Ser Glu Leu Arg Glu Ala Val 
    130                 135                 140                 


Pro Glu Pro Val Leu Leu Ser Arg Ala Glu Leu Arg Leu Leu Arg Leu 
145                 150                 155                 160 


Lys Leu Lys Val Glu Gln His Val Glu Leu Tyr Gln Lys Tyr Ser Asn 
                165                 170                 175     


Asn Ser Trp Arg Tyr Leu Ser Asn Arg Leu Leu Ala Pro Ser Asp Ser 
            180                 185                 190         


Pro Glu Trp Leu Ser Phe Asp Val Thr Gly Val Val Arg Gln Trp Leu 
        195                 200                 205             


Ser Arg Gly Gly Glu Ile Glu Gly Phe Arg Leu Ser Ala His Cys Ser 
    210                 215                 220                 


Cys Asp Ser Arg Asp Asn Thr Leu Gln Val Asp Ile Asn Gly Phe Thr 
225                 230                 235                 240 


Thr Gly Arg Arg Gly Asp Leu Ala Thr Ile His Gly Met Asn Arg Pro 
                245                 250                 255     


Phe Leu Leu Leu Met Ala Thr Pro Leu Glu Arg Ala Gln His Leu Gln 
            260                 265                 270         


Ser Ser Arg His Arg Arg Ala Leu Asp Thr Asn Tyr Cys Phe Ser Ser 
        275                 280                 285             


Thr Glu Lys Asn Cys Cys Val Arg Gln Leu Tyr Ile Asp Phe Arg Lys 
    290                 295                 300                 


Asp Leu Gly Trp Lys Trp Ile His Glu Pro Lys Gly Tyr His Ala Asn 
305                 310                 315                 320 


Phe Cys Leu Gly Pro Cys Pro Tyr Ile Trp Ser Leu Asp Thr Gln Tyr 
                325                 330                 335     


Ser Lys Val Leu Ala Leu Tyr Asn Gln His Asn Pro Gly Ala Ser Ala 
            340                 345                 350         


Ala Pro Cys Cys Val Pro Gln Ala Leu Glu Pro Leu Pro Ile Val Tyr 
        355                 360                 365             


Tyr Val Gly Arg Lys Pro Lys Val Glu Gln Leu Ser Asn Met Ile Val 
    370                 375                 380                 


Arg Ser Cys Lys Cys Ser 
385                 390 


<210>  19
<211>  390
<212>  PRT
<213>  synthetic

<400>  19

Met Pro Pro Ser Gly Leu Arg Leu Leu Leu Leu Leu Leu Pro Leu Leu 
1               5                   10                  15      


Trp Leu Leu Val Leu Thr Pro Gly Arg Pro Ala Ala Gly Leu Ser Thr 
            20                  25                  30          


Cys Lys Thr Ile Asp Met Glu Leu Val Lys Arg Lys Arg Ile Glu Ala 
        35                  40                  45              


Ile Arg Gly Gln Ile Leu Ser Lys Leu Arg Leu Ala Ser Pro Pro Ser 
    50                  55                  60                  


Gln Gly Glu Val Pro Pro Gly Pro Leu Pro Glu Ala Val Leu Ala Leu 
65                  70                  75                  80  


Tyr Asn Ser Thr Arg Asp Arg Val Ala Gly Glu Ser Ala Glu Pro Glu 
                85                  90                  95      


Pro Glu Pro Glu Ala Asp Tyr Tyr Ala Lys Glu Val Thr Arg Val Leu 
            100                 105                 110         


Met Val Glu Thr His Asn Glu Ile Tyr Asp Lys Phe Lys Gln Ser Thr 
        115                 120                 125             


His Ser Ile Tyr Met Phe Phe Asn Thr Ser Glu Leu Arg Glu Ala Val 
    130                 135                 140                 


Pro Glu Pro Val Leu Leu Ser Arg Ala Glu Leu Arg Leu Leu Arg Leu 
145                 150                 155                 160 


Lys Leu Lys Val Glu Gln His Val Glu Leu Tyr Gln Lys Tyr Ser Asn 
                165                 170                 175     


Asn Ser Trp Arg Tyr Leu Ser Asn Arg Leu Leu Ala Pro Ser Asp Ser 
            180                 185                 190         


Pro Glu Trp Leu Ser Phe Asp Val Thr Gly Val Val Arg Gln Trp Leu 
        195                 200                 205             


Ser Arg Gly Gly Glu Ile Glu Gly Phe Arg Leu Ser Ala His Val Ser 
    210                 215                 220                 


Val Asp Ser Arg Asp Asn Thr Leu Gln Val Asp Ile Asn Gly Phe Thr 
225                 230                 235                 240 


Thr Gly Arg Arg Gly Asp Leu Ala Thr Ile His Gly Met Asn Arg Pro 
                245                 250                 255     


Phe Leu Leu Leu Met Ala Thr Pro Leu Glu Arg Ala Gln His Leu Gln 
            260                 265                 270         


Ser Ser Arg His Arg Arg Ala Leu Asp Thr Asn Tyr Cys Phe Ser Ser 
        275                 280                 285             


Thr Glu Lys Asn Cys Cys Val Arg Gln Leu Tyr Ile Asp Phe Arg Lys 
    290                 295                 300                 


Asp Leu Gly Trp Lys Trp Ile His Glu Pro Lys Gly Tyr His Ala Asn 
305                 310                 315                 320 


Phe Cys Leu Gly Pro Cys Pro Tyr Ile Trp Ser Leu Asp Thr Gln Tyr 
                325                 330                 335     


Ser Lys Val Leu Ala Leu Tyr Asn Gln His Asn Pro Gly Ala Ser Ala 
            340                 345                 350         


Ala Pro Cys Cys Val Pro Gln Ala Leu Glu Pro Leu Pro Ile Val Tyr 
        355                 360                 365             


Tyr Val Gly Arg Lys Pro Lys Val Glu Gln Leu Ser Asn Met Ile Val 
    370                 375                 380                 


Arg Ser Cys Lys Cys Ser 
385                 390 


<210>  20
<211>  228
<212>  DNA
<213>  synthetic

<400>  20
cgactgtgcc ttctagttgc cagccatctg ttgtttgccc ctcccccgtg ccttccttga       60

ccctggaagg tgccactccc actgtccttt cctaataaaa tgaggaaatt gcatcgcatt      120

gtctgagtag gtgtcattct attctggggg gtggggtggg gcaggacagc aagggggagg      180

attgggaaga caatagcagg catgctgggg atgcggtggg ctctatgg                   228


<210>  21
<211>  31
<212>  PRT
<213>  homo sapiens

<400>  21

His Ala Glu Gly Thr Phe Thr Ser Asp Val Ser Ser Tyr Leu Glu Gly 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Val Lys Gly Arg Gly 
            20                  25                  30      


<210>  22
<211>  31
<212>  PRT
<213>  synthetic

<400>  22

His Ala Glu Gly Thr Phe Thr Ser Asp Val Ser Ser Tyr Leu Glu Gly 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Val Arg Gly Arg Gly 
            20                  25                  30      


<210>  23
<211>  31
<212>  PRT
<213>  synthetic


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  2-aminoisobutyric acid

<400>  23

His Xaa Glu Gly Thr Phe Thr Ser Asp Val Ser Ser Tyr Leu Glu Gly 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Val Arg Gly Arg Gly 
            20                  25                  30      


<210>  24
<211>  6401
<212>  DNA
<213>  synthetic

<400>  24
gactcttcgc gatgtacggg ccagatatac gcgttgacat tgattattga ctagttatta       60

atagtaatca attacggggt cattagttca tagcccatat atggagttcc gcgttacata      120

acttacggta aatggcccgc ctggctgacc gcccaacgac ccccgcccat tgacgtcaat      180

aatgacgtat gttcccatag taacgccaat agggactttc cattgacgtc aatgggtgga      240

ctatttacgg taaactgccc acttggcagt acatcaagtg tatcatatgc caagtacgcc      300

ccctattgac gtcaatgacg gtaaatggcc cgcctggcat tatgcccagt acatgacctt      360

atgggacttt cctacttggc agtacatcta cgtattagtc atcgctatta ccatggtgat      420

gcggttttgg cagtacatca atgggcgtgg atagcggttt gactcacggg gatttccaag      480

tctccacccc attgacgtca atgggagttt gttttggcac caaaatcaac gggactttcc      540

aaaatgtcgt aacaactccg ccccattgac gcaaatgggc ggtaggcgtg tacggtggga      600

ggtctatata agcagagctc tctggctaac tagagaaccc actgcttact ggcttatcga      660

aattaatacg actcactata gggagaccca agctggctag cgtttaaact taagcttggt      720

accgagctcg gatccactag tccagtgtgg tggaattctg cactgcagct cgcatctctc      780

cttcacgcgc ccgccgccct acctgaggcc gccatccacg ccggttgagt cgcgttctgc      840

cgcctcccgc ctgtggtgcc tcctgaactg cgtccgccgt ctaggtaagt ttaaagctca      900

ggtcgagacc gggcctttgt ccggcgctcc cttggagcct acctagactc agccggctct      960

ccacgctttg cctgaccctg cttgctcaac tctaggtaag ttaatgagac agatagaaac     1020

tggtcttgta gaaacagagt agtcgcctgc ttttctgcca ggtgctgact tctctcccct     1080

gggctttttt ctttttctca ggttgaaaag aagaagacga agaagacgaa gaagacaaac     1140

cgtcgtcgac tgccatgcgc cgctgattaa cgccgccacc atggcccacc gacgcagatc     1200

cagaagctgc cgtgaggacc agaagcccgt gatggatgat cagagggacc ttatctctaa     1260

caatgaacaa ctgccaatgc tcggcagacg gcctggggcc ccggagagca agtgcagcag     1320

aggagccttg tacacggggt tctccatttt agtgactctc cttctcgccg gccaagctac     1380

caccgcctac tttctgtacc aacagcaagg cagactagac aaactgacaa tcacaagcca     1440

gaaccttcag ctggagtctc tgcggatgaa gctgcccgct ttgtggatga gattgcttcc     1500

tctacttgct ctcctggcgc tctggggacc tgaccccgag caagagtttg ttaatcagca     1560

cctgtgtggg agtcatctgg tggaggcact ctatttagtg tgcggagaga ggggcttctt     1620

ctacactcca aagaccagac gggaggccga agaccttcaa gtggggcaag tagaactggg     1680

tggcggaccc ggtgccggga gccttcagcc gctcgccctg gagggctctc ttcagaaacg     1740

cggcatcgtg gagcagtgtt gcacatccat ttgctcactc taccagctgg agaactactg     1800

caacggaagc ggagtgaagc agacgttgaa ttttgatttg ttgaagttgg cgggggatgt     1860

ggagagcaat ccggggccga tgccccctag tggcctcaga cttttgttat tgttattacc     1920

gcttttatgg ctcttggtgc tgacaccggg ccgtccggct gctggcttgt cgacttgtaa     1980

gacaattgat atggaattgg tgaaacgaaa acggattgag gccatccgag gacagatttt     2040

gagcaagctg cggcttgcct cgccaccctc gcaaggggaa gtcccacccg gacctctacc     2100

agaagcagtc ctagcgctgt acaacagtac aagagataga gtggccgggg aatccgcaga     2160

accagagcct gagcctgaag ccgattatta tgcaaaggaa gtgactaggg tcctgatggt     2220

cgagacccat aacgaaatct acgacaaatt caaacaaagt acccactcta tctacatgtt     2280

cttcaacacc agtgagctaa gagaagccgt gcccgaacct gtgcttcttt cccgcgcaga     2340

actccgcctc ttgagactca aattgaaagt tgaacaacac gtagagcttt accagaaata     2400

ctctaataat tcatggcgat atctttctaa tcgtctcctc gccccatctg acagccctga     2460

atggctctcc ttcgacgtta cgggagttgt gcgccagtgg ctcagcagag gcggagagat     2520

agagggcttt cggctgagcg cacatgtatc tgtggactca agggacaaca cattgcaagt     2580

ggatattaac ggttttacaa ctggacggag aggggacctg gcgaccatcc acggcatgaa     2640

tagacctttc ctgctgctga tggctactcc cctggagagg gcacagcact tacagtcttc     2700

cagacaccgg cgcgccctgg atacaaacta ctgcttcagc tccaccgaaa agaactgttg     2760

cgtgcggcag ctgtacattg acttcagaaa ggatctgggc tggaagtgga ttcatgagcc     2820

caaggggtat catgccaact tctgtcttgg gccatgccca tacatctggt cactggatac     2880

ccagtactcc aaagttctgg ccttgtacaa tcaacacaac cctggagctt ccgccgctcc     2940

ttgctgtgtg ccccaagccc tagagcccct gcccatcgtt tattatgtcg gacgcaagcc     3000

caaagtagaa cagctatcaa atatgatcgt gagaagctgc aagtgtagct gataaacgcg     3060

tcgagcatgc atctagggcg gccaattccg cccctctccc ccccacccct ctccctcccc     3120

cccccctaac gttactggcc gaagccgctt ggaataaggc cggtgtgcgt ttgtctatat     3180

gttattttcc accatattgc cgtcttttgg caatgtgagg gcccggaaac ctggccctgt     3240

cttcttgacg agcattccta ggggtctttc ccctctcgcc aaaggaatgc aaggtctgtt     3300

gaatgtcgtg aaggaagcag ttcctctgga agcttcttga agacaaacaa cgtctgtagc     3360

gaccctttgt agacagcgga accccccacc tggcgataga tgcctctgcg gccaaaagcc     3420

acgtgtataa gatacacctg caaaggcggc acaaccccag tgccacgttg tgagttggat     3480

agttgtggaa agagtcaaat ggctctcctc aagcgtattc aacaaggggc tgaaggatgc     3540

ccagaaggta ccccattgta tgggatctga tctggggcct cggtgcacat gctttacatg     3600

tgtttagtcg aggttaaaaa acgtctaggc cccccgaacc acggggacgt ggttttcctt     3660

tgaaaaacac gatgataata tggctgccgc tcattctagt gcccttcttt gctgcctggt     3720

cctgctcacc ggggtgcgag ctagccctgg acaagggaca caatccgaaa actcgtgcac     3780

ccacttcccg ggcaacctcc ctaacatgct gagggacctc cgtgatgcct tcagtagagt     3840

gaagacgttc ttccaaatga aagatcagtt agataacctg ctcctgaagg agtcactctt     3900

agaagacttc aaaggatacc tcggctgcca agcacttagc gagatgattc aattctactt     3960

agaagaagtc atgcctcaag ctgagaatca agaccccgac atcaaagctc atgtgaattc     4020

tttgggagaa aatttgaaga ctttgcggct gcggctgcgg agatgtcacc gctttctgcc     4080

ctgtgagaac aaatcaaaag cggtcgagca agttaagaat gccttcaata agctacaaga     4140

gaagggcatc tacaaagcaa tgagcgagtt tgatatcttt atcaattaca ttgaagccta     4200

catgacaatg aagattagga atgccgcggg gagcggcgct actaacttca gcctgctgaa     4260

gcaggctgga gacgtggagg agaaccctgg acctatgtac agaatgcagc tgctgagctg     4320

catcgccctg agcctggccc tggtgaccaa cagcgcaccc acgtcctcta gcaccaagaa     4380

gacccagtta cagttggagc atctactttt agacctgcaa atgattttga acggcatcaa     4440

caactacaag aatcctaaac ttactcgcat gcttaccttc aaattttaca tgcccaagaa     4500

ggccaccgaa ctgaagcact tgcaatgtct ggaggaagaa ctcaagccgc tggaggaagt     4560

tctcaacctc gcgcagtcca agaatttcca cctccggcca agagacctga tcagtaacat     4620

taatgtgata gtgctggagc tgaagggaag cgagactaca tttatgtgcg agtacgccga     4680

tgaaaccgct acaatcgtcg agttcctgaa tagatggatc acattttgcc agtcaattat     4740

ctctactctg acatgataac tcgaggtcta gagggcccgt ttaaacccgc tgatcagcct     4800

cgactgtgcc ttctagttgc cagccatctg ttgtttgccc ctcccccgtg ccttccttga     4860

ccctggaagg tgccactccc actgtccttt cctaataaaa tgaggaaatt gcatcgcatt     4920

gtctgagtag gtgtcattct attctggggg gtggggtggg gcaggacagc aagggggagg     4980

attgggaaga caatagcagg catgctgggg atgcggtggg ctctatggct tctactgggc     5040

ggttttatgg acagcaagcg aaccggaatt gccagctggg gcgccctctg gtaaggttgg     5100

gaagccctgc aaagtaaact ggatggcttt ctcgccgcca aggatctgat ggcgcagggg     5160

atcaagctct gatcaagaga caggatgagg atcgtttcgc atggccaaag aagacaatat     5220

tgaaatgcaa ggtaccgttc ttgaaacgtt gcctaatacc atgttccgcg tagagttaga     5280

aaacggtcac gtggttactg cacacatctc cggtaaaatg cgcaaaaact acatccgcat     5340

cctgacgggc gacaaagtga ctgttgaact gaccccgtac gacctgagca aaggccgcat     5400

tgtcttccgt agtcgctgat aaattattaa cgcttacaat ttcctgatgc ggtattttct     5460

ccttacgcat ctgtgcggta tttcacaccg catacaggtg gcacttttcg gggaaatgtg     5520

cgcggaaccc ctatttgttt atttttctaa atacattcaa atatgtatcc gctcatgaga     5580

caataaccct gataaatgct tcaataatag cacgtgctaa aacttcattt ttaatttaaa     5640

aggatctagg tgaagatcct ttttgataat ctcatgacca aaatccctta acgtgagttt     5700

tcgttccact gagcgtcaga ccccgtagaa aagatcaaag gatcttcttg agatcctttt     5760

tttctgcgcg taatctgctg cttgcaaaca aaaaaaccac cgctaccagc ggtggtttgt     5820

ttgccggatc aagagctacc aactcttttt ccgaaggtaa ctggcttcag cagagcgcag     5880

ataccaaata ctgttcttct agtgtagccg tagttaggcc accacttcaa gaactctgta     5940

gcaccgccta catacctcgc tctgctaatc ctgttaccag tggctgctgc cagtggcgat     6000

aagtcgtgtc ttaccgggtt ggactcaaga cgatagttac cggataaggc gcagcggtcg     6060

ggctgaacgg ggggttcgtg cacacagccc agcttggagc gaacgaccta caccgaactg     6120

agatacctac agcgtgagct atgagaaagc gccacgcttc ccgaagggag aaaggcggac     6180

aggtatccgg taagcggcag ggtcggaaca ggagagcgca cgagggagct tccaggggga     6240

aacgcctggt atctttatag tcctgtcggg tttcgccacc tctgacttga gcgtcgattt     6300

ttgtgatgct cgtcaggggg gcggagccta tggaaaaacg ccagcaacgc ggccttttta     6360

cggttcctgg gcttttgctg gccttttgct cacatgttct t                         6401


<210>  25
<211>  390
<212>  PRT
<213>  synthetic

<400>  25

Met Pro Pro Ser Gly Leu Arg Leu Leu Leu Leu Leu Leu Pro Leu Leu 
1               5                   10                  15      


Trp Leu Leu Val Leu Thr Pro Gly Arg Pro Ala Ala Gly Leu Ser Thr 
            20                  25                  30          


Cys Lys Thr Ile Asp Met Glu Leu Val Lys Arg Lys Arg Ile Glu Ala 
        35                  40                  45              


Ile Arg Gly Gln Ile Leu Ser Lys Leu Arg Leu Ala Ser Pro Pro Ser 
    50                  55                  60                  


Gln Gly Glu Val Pro Pro Gly Pro Leu Pro Glu Ala Val Leu Ala Leu 
65                  70                  75                  80  


Tyr Asn Ser Thr Arg Asp Arg Val Ala Gly Glu Ser Ala Glu Pro Glu 
                85                  90                  95      


Pro Glu Pro Glu Ala Asp Tyr Tyr Ala Lys Glu Val Thr Arg Val Leu 
            100                 105                 110         


Met Val Glu Thr His Asn Glu Ile Tyr Asp Lys Phe Lys Gln Ser Thr 
        115                 120                 125             


His Ser Ile Tyr Met Phe Phe Asn Thr Ser Glu Leu Arg Glu Ala Val 
    130                 135                 140                 


Pro Glu Pro Val Leu Leu Ser Arg Ala Glu Leu Arg Leu Leu Arg Leu 
145                 150                 155                 160 


Lys Leu Lys Val Glu Gln His Val Glu Leu Tyr Gln Lys Tyr Ser Asn 
                165                 170                 175     


Asn Ser Trp Arg Tyr Leu Ser Asn Arg Leu Leu Ala Pro Ser Asp Ser 
            180                 185                 190         


Pro Glu Trp Leu Ser Phe Asp Val Thr Gly Val Val Arg Gln Trp Leu 
        195                 200                 205             


Ser Arg Gly Gly Glu Ile Glu Gly Phe Arg Leu Ser Ala His Ser Ser 
    210                 215                 220                 


Ser Asp Ser Arg Asp Asn Thr Leu Gln Val Asp Ile Asn Gly Phe Thr 
225                 230                 235                 240 


Thr Gly Arg Arg Gly Asp Leu Ala Thr Ile His Gly Met Asn Arg Pro 
                245                 250                 255     


Phe Leu Leu Leu Met Ala Thr Pro Leu Glu Arg Ala Gln His Leu Gln 
            260                 265                 270         


Ser Ser Arg His Arg Arg Ala Leu Asp Thr Asn Tyr Cys Phe Ser Ser 
        275                 280                 285             


Thr Glu Lys Asn Cys Cys Val Arg Gln Leu Tyr Ile Asp Phe Arg Lys 
    290                 295                 300                 


Asp Leu Gly Trp Lys Trp Ile His Glu Pro Lys Gly Tyr His Ala Asn 
305                 310                 315                 320 


Phe Cys Leu Gly Pro Cys Pro Tyr Ile Trp Ser Leu Asp Thr Gln Tyr 
                325                 330                 335     


Ser Lys Val Leu Ala Leu Tyr Asn Gln His Asn Pro Gly Ala Ser Ala 
            340                 345                 350         


Ala Pro Cys Cys Val Pro Gln Ala Leu Glu Pro Leu Pro Ile Val Tyr 
        355                 360                 365             


Tyr Val Gly Arg Lys Pro Lys Val Glu Gln Leu Ser Asn Met Ile Val 
    370                 375                 380                 


Arg Ser Cys Lys Cys Ser 
385                 390 


<210>  26
<211>  6389
<212>  DNA
<213>  synthetic

<400>  26
gactcttcgc gatgtacggg ccagatatac gcgttgacat tgattattga ctagttatta       60

atagtaatca attacggggt cattagttca tagcccatat atggagttcc gcgttacata      120

acttacggta aatggcccgc ctggctgacc gcccaacgac ccccgcccat tgacgtcaat      180

aatgacgtat gttcccatag taacgccaat agggactttc cattgacgtc aatgggtgga      240

ctatttacgg taaactgccc acttggcagt acatcaagtg tatcatatgc caagtacgcc      300

ccctattgac gtcaatgacg gtaaatggcc cgcctggcat tatgcccagt acatgacctt      360

atgggacttt cctacttggc agtacatcta cgtattagtc atcgctatta ccatggtgat      420

gcggttttgg cagtacatca atgggcgtgg atagcggttt gactcacggg gatttccaag      480

tctccacccc attgacgtca atgggagttt gttttggcac caaaatcaac gggactttcc      540

aaaatgtcgt aacaactccg ccccattgac gcaaatgggc ggtaggcgtg tacggtggga      600

ggtctatata agcagagctc tctggctaac tagagaaccc actgcttact ggcttatcga      660

aattaatacg actcactata gggagaccca agctggctag cgtttaaact taagcttggt      720

accgagctcg gatccactag tccagtgtgg tggaattctg cactgcagct cgcatctctc      780

cttcacgcgc ccgccgccct acctgaggcc gccatccacg ccggttgagt cgcgttctgc      840

cgcctcccgc ctgtggtgcc tcctgaactg cgtccgccgt ctaggtaagt ttaaagctca      900

ggtcgagacc gggcctttgt ccggcgctcc cttggagcct acctagactc agccggctct      960

ccacgctttg cctgaccctg cttgctcaac tctaggtaag ttaatgagac agatagaaac     1020

tggtcttgta gaaacagagt agtcgcctgc ttttctgcca ggtgctgact tctctcccct     1080

gggctttttt ctttttctca ggttgaaaag aagaagacga agaagacgaa gaagacaaac     1140

cgtcgtcgac tgccatgcgc cgctgattaa cgccgccacc atggcccacc gacgcagatc     1200

cagaagctgc cgtgaggacc agaagcccgt gatggatgat cagagggacc ttatctctaa     1260

caatgaacaa ctgccaatgc tcggcagacg gcctggggcc ccggagagca agtgcagcag     1320

aggagccttg tacacggggt tctccatttt agtgactctc cttctcgccg gccaagctac     1380

caccgcctac tttctgtacc aacagcaagg cagactagac aaactgacaa tcacaagcca     1440

gaaccttcag ctggagtctc tgcggatgaa gctgcccgct ttgtggatga gattgcttcc     1500

tctacttgct ctcctggcgc tctggggacc tgaccccgag caagagtttg ttaatcagca     1560

cctgtgtggg agtcatctgg tggaggcact ctatttagtg tgcggagaga ggggcttctt     1620

ctacactcca aagaccagac gggaggccga agaccttcaa gtggggcaag tagaactggg     1680

tggcggaccc ggtgccggga gccttcagcc gctcgccctg gagggctctc ttcagaaacg     1740

cggcatcgtg gagcagtgtt gcacatccat ttgctcactc taccagctgg agaactactg     1800

caacggaagc ggagtgaagc agacgttgaa ttttgatttg ttgaagttgg cgggggatgt     1860

ggagagcaat ccggggccga tgccccctag tggcctcaga cttttgttat tgttattacc     1920

gcttttatgg ctcttggtgc tgacaccggg ccgtccggct gctggcttgt cgacttgtaa     1980

gacaattgat atggaattgg tgaaacgaaa acggattgag gccatccgag gacagatttt     2040

gagcaagctg cggcttgcct cgccaccctc gcaaggggaa gtcccacccg gacctctacc     2100

agaagcagtc ctagcgctgt acaacagtac aagagataga gtggccgggg aatccgcaga     2160

accagagcct gagcctgaag ccgattatta tgcaaaggaa gtgactaggg tcctgatggt     2220

cgagacccat aacgaaatct acgacaaatt caaacaaagt acccactcta tctacatgtt     2280

cttcaacacc agtgagctaa gagaagccgt gcccgaacct gtgcttcttt cccgcgcaga     2340

actccgcctc ttgagactca aattgaaagt tgaacaacac gtagagcttt accagaaata     2400

ctctaataat tcatggcgat atctttctaa tcgtctcctc gccccatctg acagccctga     2460

atggctctcc ttcgacgtta cgggagttgt gcgccagtgg ctcagcagag gcggagagat     2520

agagggcttt cggctgagcg cacatagctc tagcgactca agggacaaca cattgcaagt     2580

ggatattaac ggttttacaa ctggacggag aggggacctg gcgaccatcc acggcatgaa     2640

tagacctttc ctgctgctga tggctactcc cctggagagg gcacagcact tacagtcttc     2700

cagacaccgg cgcgccctgg atacaaacta ctgcttcagc tccaccgaaa agaactgttg     2760

cgtgcggcag ctgtacattg acttcagaaa ggatctgggc tggaagtgga ttcatgagcc     2820

caaggggtat catgccaact tctgtcttgg gccatgccca tacatctggt cactggatac     2880

ccagtactcc aaagttctgg ccttgtacaa tcaacacaac cctggagctt ccgccgctcc     2940

ttgctgtgtg ccccaagccc tagagcccct gcccatcgtt tattatgtcg gacgcaagcc     3000

caaagtagaa cagctatcaa atatgatcgt gagaagctgc aagtgtagct gataaacgcg     3060

tcgagcatgc atctagggcg gccaattccg cccctctccc ccccacccct ctccctcccc     3120

cccccctaac gttactggcc gaagccgctt ggaataaggc cggtgtgcgt ttgtctatat     3180

gttattttcc accatattgc cgtcttttgg caatgtgagg gcccggaaac ctggccctgt     3240

cttcttgacg agcattccta ggggtctttc ccctctcgcc aaaggaatgc aaggtctgtt     3300

gaatgtcgtg aaggaagcag ttcctctgga agcttcttga agacaaacaa cgtctgtagc     3360

gaccctttgt agacagcgga accccccacc tggcgataga tgcctctgcg gccaaaagcc     3420

acgtgtataa gatacacctg caaaggcggc acaaccccag tgccacgttg tgagttggat     3480

agttgtggaa agagtcaaat ggctctcctc aagcgtattc aacaaggggc tgaaggatgc     3540

ccagaaggta ccccattgta tgggatctga tctggggcct cggtgcacat gctttacatg     3600

tgtttagtcg aggttaaaaa acgtctaggc cccccgaacc acggggacgt ggttttcctt     3660

tgaaaaacac gatgataata tgatgcacag ctcagcactg ctctgttgcc tggtcctcct     3720

gactggggtg agggccagcc caggccaggg cacccagtct gagaacagct gcacccactt     3780

cccaggcaac ctgcctaaca tgcttcgaga tctccgagat gccttcagca gagtgaagac     3840

tttctttcaa atgaaggatc agctggacaa cttgttgtta aaggagtcct tgctggagga     3900

ctttaagggt tacctgggtt gccaagcctt gtctgagatg atccagtttt acctggagga     3960

ggtgatgccc caagctgaga accaagaccc agacatcaag gcgcatgtga actccctggg     4020

ggagaacctg aagaccctca ggctgaggct acggcgctgt catcgatttc ttccctgtga     4080

aaacaagagc aaggccgtgg agcaggtgaa gaatgccttt aataagctcc aagagaaagg     4140

catctacaaa gccatgagtg agtttgacat cttcatcaac tacatagaag cctacatgac     4200

aatgaagata cgaaacggga gcggcgctac taacttcagc ctgctgaagc aggctggaga     4260

cgtggaggag aaccctggac ctatgtacag aatgcagctg ctgagctgca tcgccctgag     4320

cctggccctg gtgaccaaca gcgcacccac gtcctctagc accaagaaga cccagttaca     4380

gttggagcat ctacttttag acctgcaaat gattttgaac ggcatcaaca actacaagaa     4440

tcctaaactt actcgcatgc ttaccttcaa attttacatg cccaagaagg ccaccgaact     4500

gaagcacttg caatgtctgg aggaagaact caagccgctg gaggaagttc tcaacctcgc     4560

gcagtccaag aatttccacc tccggccaag agacctgatc agtaacatta atgtgatagt     4620

gctggagctg aagggaagcg agactacatt tatgtgcgag tacgccgatg aaaccgctac     4680

aatcgtcgag ttcctgaata gatggatcac attttgccag tcaattatct ctactctgac     4740

atgataactc gaggtctaga gggcccgttt aaacccgctg atcagcctcg actgtgcctt     4800

ctagttgcca gccatctgtt gtttgcccct cccccgtgcc ttccttgacc ctggaaggtg     4860

ccactcccac tgtcctttcc taataaaatg aggaaattgc atcgcattgt ctgagtaggt     4920

gtcattctat tctggggggt ggggtggggc aggacagcaa gggggaggat tgggaagaca     4980

atagcaggca tgctggggat gcggtgggct ctatggcttc tactgggcgg ttttatggac     5040

agcaagcgaa ccggaattgc cagctggggc gccctctggt aaggttggga agccctgcaa     5100

agtaaactgg atggctttct cgccgccaag gatctgatgg cgcaggggat caagctctga     5160

tcaagagaca ggatgaggat cgtttcgcat ggccaaagaa gacaatattg aaatgcaagg     5220

taccgttctt gaaacgttgc ctaataccat gttccgcgta gagttagaaa acggtcacgt     5280

ggttactgca cacatctccg gtaaaatgcg caaaaactac atccgcatcc tgacgggcga     5340

caaagtgact gttgaactga ccccgtacga cctgagcaaa ggccgcattg tcttccgtag     5400

tcgctgataa attattaacg cttacaattt cctgatgcgg tattttctcc ttacgcatct     5460

gtgcggtatt tcacaccgca tacaggtggc acttttcggg gaaatgtgcg cggaacccct     5520

atttgtttat ttttctaaat acattcaaat atgtatccgc tcatgagaca ataaccctga     5580

taaatgcttc aataatagca cgtgctaaaa cttcattttt aatttaaaag gatctaggtg     5640

aagatccttt ttgataatct catgaccaaa atcccttaac gtgagttttc gttccactga     5700

gcgtcagacc ccgtagaaaa gatcaaagga tcttcttgag atcctttttt tctgcgcgta     5760

atctgctgct tgcaaacaaa aaaaccaccg ctaccagcgg tggtttgttt gccggatcaa     5820

gagctaccaa ctctttttcc gaaggtaact ggcttcagca gagcgcagat accaaatact     5880

gttcttctag tgtagccgta gttaggccac cacttcaaga actctgtagc accgcctaca     5940

tacctcgctc tgctaatcct gttaccagtg gctgctgcca gtggcgataa gtcgtgtctt     6000

accgggttgg actcaagacg atagttaccg gataaggcgc agcggtcggg ctgaacgggg     6060

ggttcgtgca cacagcccag cttggagcga acgacctaca ccgaactgag atacctacag     6120

cgtgagctat gagaaagcgc cacgcttccc gaagggagaa aggcggacag gtatccggta     6180

agcggcaggg tcggaacagg agagcgcacg agggagcttc cagggggaaa cgcctggtat     6240

ctttatagtc ctgtcgggtt tcgccacctc tgacttgagc gtcgattttt gtgatgctcg     6300

tcaggggggc ggagcctatg gaaaaacgcc agcaacgcgg cctttttacg gttcctgggc     6360

ttttgctggc cttttgctca catgttctt                                       6389


<210>  27
<211>  15
<212>  PRT
<213>  synthetic

<400>  27

Ser His Leu Val Glu Ala Leu Tyr Leu Val Cys Gly Gly Glu Gly 
1               5                   10                  15  


<210>  28
<211>  6383
<212>  DNA
<213>  synthetic

<400>  28
gactcttcgc gatgtacggg ccagatatac gcgttgacat tgattattga ctagttatta       60

atagtaatca attacggggt cattagttca tagcccatat atggagttcc gcgttacata      120

acttacggta aatggcccgc ctggctgacc gcccaacgac ccccgcccat tgacgtcaat      180

aatgacgtat gttcccatag taacgccaat agggactttc cattgacgtc aatgggtgga      240

ctatttacgg taaactgccc acttggcagt acatcaagtg tatcatatgc caagtacgcc      300

ccctattgac gtcaatgacg gtaaatggcc cgcctggcat tatgcccagt acatgacctt      360

atgggacttt cctacttggc agtacatcta cgtattagtc atcgctatta ccatggtgat      420

gcggttttgg cagtacatca atgggcgtgg atagcggttt gactcacggg gatttccaag      480

tctccacccc attgacgtca atgggagttt gttttggcac caaaatcaac gggactttcc      540

aaaatgtcgt aacaactccg ccccattgac gcaaatgggc ggtaggcgtg tacggtggga      600

ggtctatata agcagagctc tctggctaac tagagaaccc actgcttact ggcttatcga      660

aattaatacg actcactata gggagaccca agctggctag cgtttaaact taagcttggt      720

accgagctcg gatccactag tccagtgtgg tggaattctg cagctcgcat ctctccttca      780

cgcgcccgcc gccctacctg aggccgccat ccacgccggt tgagtcgcgt tctgccgcct      840

cccgcctgtg gtgcctcctg aactgcgtcc gccgtctagg taagtttaaa gctcaggtcg      900

agaccgggcc tttgtccggc gctcccttgg agcctaccta gactcagccg gctctccacg      960

ctttgcctga ccctgcttgc tcaactctag gtaagttaat gagacagata gaaactggtc     1020

ttgtagaaac agagtagtcg cctgcttttc tgccaggtgc tgacttctct cccctgggct     1080

tttttctttt tctcaggttg aaaagaagaa gacgaagaag acgaagaaga caaaccgtcg     1140

tcgactgcca tgcgccgctg attaacgccg ccaccatggc ccaccgacgc agatccagaa     1200

gctgccgtga ggaccagaag cccgtgatgg atgatcagag ggaccttatc tctaacaatg     1260

aacaactgcc aatgctcggc agacggcctg gggccccgga gagcaagtgc agcagaggag     1320

ccttgtacac ggggttctcc attttagtga ctctccttct cgccggccaa gctaccaccg     1380

cctactttct gtaccaacag caaggcagac tagacaaact gacaatcaca agccagaacc     1440

ttcagctgga gtctctgcgg atgaagctgc ccgctttgtg gatgagattg cttcctctac     1500

ttgctctcct ggcgctctgg ggacctgacc ccgagcaaga gtttgttaat cagcacctgt     1560

gtgggagtca tctggtggag gcactctatt tagtgtgcgg agagaggggc ttcttctaca     1620

ctccaaagac cagacgggag gccgaagacc ttcaagtggg gcaagtagaa ctgggtggcg     1680

gacccggtgc cgggagcctt cagccgctcg ccctggaggg ctctcttcag aaacgcggca     1740

tcgtggagca gtgttgcaca tccatttgct cactctacca gctggagaac tactgcaacg     1800

gaagcggagt gaagcagacg ttgaattttg atttgttgaa gttggcgggg gatgtggaga     1860

gcaatccggg gccgatgccc cctagtggcc tcagactttt gttattgtta ttaccgcttt     1920

tatggctctt ggtgctgaca ccgggccgtc cggctgctgg cttgtcgact tgtaagacaa     1980

ttgatatgga attggtgaaa cgaaaacgga ttgaggccat ccgaggacag attttgagca     2040

agctgcggct tgcctcgcca ccctcgcaag gggaagtccc acccggacct ctaccagaag     2100

cagtcctagc gctgtacaac agtacaagag atagagtggc cggggaatcc gcagaaccag     2160

agcctgagcc tgaagccgat tattatgcaa aggaagtgac tagggtcctg atggtcgaga     2220

cccataacga aatctacgac aaattcaaac aaagtaccca ctctatctac atgttcttca     2280

acaccagtga gctaagagaa gccgtgcccg aacctgtgct tctttcccgc gcagaactcc     2340

gcctcttgag actcaaattg aaagttgaac aacacgtaga gctttaccag aaatactcta     2400

ataattcatg gcgatatctt tctaatcgtc tcctcgcccc atctgacagc cctgaatggc     2460

tctccttcga cgttacggga gttgtgcgcc agtggctcag cagaggcgga gagatagagg     2520

gctttcggct gagcgcacat agctctagcg actcaaggga caacacattg caagtggata     2580

ttaacggttt tacaactgga cggagagggg acctggcgac catccacggc atgaatagac     2640

ctttcctgct gctgatggct actcccctgg agagggcaca gcacttacag tcttccagac     2700

accggcgcgc cctggataca aactactgct tcagctccac cgaaaagaac tgttgcgtgc     2760

ggcagctgta cattgacttc agaaaggatc tgggctggaa gtggattcat gagcccaagg     2820

ggtatcatgc caacttctgt cttgggccat gcccatacat ctggtcactg gatacccagt     2880

actccaaagt tctggccttg tacaatcaac acaaccctgg agcttccgcc gctccttgct     2940

gtgtgcccca agccctagag cccctgccca tcgtttatta tgtcggacgc aagcccaaag     3000

tagaacagct atcaaatatg atcgtgagaa gctgcaagtg tagctgataa acgcgtcgag     3060

catgcatcta gggcggccaa ttccgcccct ctccccccca cccctctccc tccccccccc     3120

ctaacgttac tggccgaagc cgcttggaat aaggccggtg tgcgtttgtc tatatgttat     3180

tttccaccat attgccgtct tttggcaatg tgagggcccg gaaacctggc cctgtcttct     3240

tgacgagcat tcctaggggt ctttcccctc tcgccaaagg aatgcaaggt ctgttgaatg     3300

tcgtgaagga agcagttcct ctggaagctt cttgaagaca aacaacgtct gtagcgaccc     3360

tttgtagaca gcggaacccc ccacctggcg atagatgcct ctgcggccaa aagccacgtg     3420

tataagatac acctgcaaag gcggcacaac cccagtgcca cgttgtgagt tggatagttg     3480

tggaaagagt caaatggctc tcctcaagcg tattcaacaa ggggctgaag gatgcccaga     3540

aggtacccca ttgtatggga tctgatctgg ggcctcggtg cacatgcttt acatgtgttt     3600

agtcgaggtt aaaaaacgtc taggcccccc gaaccacggg gacgtggttt tcctttgaaa     3660

aacacgatga taatatgatg cacagctcag cactgctctg ttgcctggtc ctcctgactg     3720

gggtgagggc cagcccaggc cagggcaccc agtctgagaa cagctgcacc cacttcccag     3780

gcaacctgcc taacatgctt cgagatctcc gagatgcctt cagcagagtg aagactttct     3840

ttcaaatgaa ggatcagctg gacaacttgt tgttaaagga gtccttgctg gaggacttta     3900

agggttacct gggttgccaa gccttgtctg agatgatcca gttttacctg gaggaggtga     3960

tgccccaagc tgagaaccaa gacccagaca tcaaggcgca tgtgaactcc ctgggggaga     4020

acctgaagac cctcaggctg aggctacggc gctgtcatcg atttcttccc tgtgaaaaca     4080

agagcaaggc cgtggagcag gtgaagaatg cctttaataa gctccaagag aaaggcatct     4140

acaaagccat gagtgagttt gacatcttca tcaactacat agaagcctac atgacaatga     4200

agatacgaaa cgggagcggc gctactaact tcagcctgct gaagcaggct ggagacgtgg     4260

aggagaaccc tggacctatg tacagaatgc agctgctgag ctgcatcgcc ctgagcctgg     4320

ccctggtgac caacagcgca cccacgtcct ctagcaccaa gaagacccag ttacagttgg     4380

agcatctact tttagacctg caaatgattt tgaacggcat caacaactac aagaatccta     4440

aacttactcg catgcttacc ttcaaatttt acatgcccaa gaaggccacc gaactgaagc     4500

acttgcaatg tctggaggaa gaactcaagc cgctggagga agttctcaac ctcgcgcagt     4560

ccaagaattt ccacctccgg ccaagagacc tgatcagtaa cattaatgtg atagtgctgg     4620

agctgaaggg aagcgagact acatttatgt gcgagtacgc cgatgaaacc gctacaatcg     4680

tcgagttcct gaatagatgg atcacatttt gccagtcaat tatctctact ctgacatgat     4740

aactcgagtc tagagggccc gtttaaaccc gctgatcagc ctcgactgtg ccttctagtt     4800

gccagccatc tgttgtttgc ccctcccccg tgccttcctt gaccctggaa ggtgccactc     4860

ccactgtcct ttcctaataa aatgaggaaa ttgcatcgca ttgtctgagt aggtgtcatt     4920

ctattctggg gggtggggtg gggcaggaca gcaaggggga ggattgggaa gacaatagca     4980

ggcatgctgg ggatgcggtg ggctctatgg cttctactgg gcggttttat ggacagcaag     5040

cgaaccggaa ttgccagctg gggcgccctc tggtaaggtt gggaagccct gcaaagtaaa     5100

ctggatggct ttctcgccgc caaggatctg atggcgcagg ggatcaagct ctgatcaaga     5160

gacaggatga ggatcgtttc gcatggccaa agaagacaat attgaaatgc aaggtaccgt     5220

tcttgaaacg ttgcctaata ccatgttccg cgtagagtta gaaaacggtc acgtggttac     5280

tgcacacatc tccggtaaaa tgcgcaaaaa ctacatccgc atcctgacgg gcgacaaagt     5340

gactgttgaa ctgaccccgt acgacctgag caaaggccgc attgtcttcc gtagtcgctg     5400

ataaattatt aacgcttaca atttcctgat gcggtatttt ctccttacgc atctgtgcgg     5460

tatttcacac cgcatacagg tggcactttt cggggaaatg tgcgcggaac ccctatttgt     5520

ttatttttct aaatacattc aaatatgtat ccgctcatga gacaataacc ctgataaatg     5580

cttcaataat agcacgtgct aaaacttcat ttttaattta aaaggatcta ggtgaagatc     5640

ctttttgata atctcatgac caaaatccct taacgtgagt tttcgttcca ctgagcgtca     5700

gaccccgtag aaaagatcaa aggatcttct tgagatcctt tttttctgcg cgtaatctgc     5760

tgcttgcaaa caaaaaaacc accgctacca gcggtggttt gtttgccgga tcaagagcta     5820

ccaactcttt ttccgaaggt aactggcttc agcagagcgc agataccaaa tactgttctt     5880

ctagtgtagc cgtagttagg ccaccacttc aagaactctg tagcaccgcc tacatacctc     5940

gctctgctaa tcctgttacc agtggctgct gccagtggcg ataagtcgtg tcttaccggg     6000

ttggactcaa gacgatagtt accggataag gcgcagcggt cgggctgaac ggggggttcg     6060

tgcacacagc ccagcttgga gcgaacgacc tacaccgaac tgagatacct acagcgtgag     6120

ctatgagaaa gcgccacgct tcccgaaggg agaaaggcgg acaggtatcc ggtaagcggc     6180

agggtcggaa caggagagcg cacgagggag cttccagggg gaaacgcctg gtatctttat     6240

agtcctgtcg ggtttcgcca cctctgactt gagcgtcgat ttttgtgatg ctcgtcaggg     6300

gggcggagcc tatggaaaaa cgccagcaac gcggcctttt tacggttcct gggcttttgc     6360

tggccttttg ctcacatgtt ctt                                             6383


<210>  29
<211>  6383
<212>  DNA
<213>  synthetic

<400>  29
gactcttcgc gatgtacggg ccagatatac gcgttgacat tgattattga ctagttatta       60

atagtaatca attacggggt cattagttca tagcccatat atggagttcc gcgttacata      120

acttacggta aatggcccgc ctggctgacc gcccaacgac ccccgcccat tgacgtcaat      180

aatgacgtat gttcccatag taacgccaat agggactttc cattgacgtc aatgggtgga      240

ctatttacgg taaactgccc acttggcagt acatcaagtg tatcatatgc caagtacgcc      300

ccctattgac gtcaatgacg gtaaatggcc cgcctggcat tatgcccagt acatgacctt      360

atgggacttt cctacttggc agtacatcta cgtattagtc atcgctatta ccatggtgat      420

gcggttttgg cagtacatca atgggcgtgg atagcggttt gactcacggg gatttccaag      480

tctccacccc attgacgtca atgggagttt gttttggcac caaaatcaac gggactttcc      540

aaaatgtcgt aacaactccg ccccattgac gcaaatgggc ggtaggcgtg tacggtggga      600

ggtctatata agcagagctc tctggctaac tagagaaccc actgcttact ggcttatcga      660

aattaatacg actcactata gggagaccca agctggctag cgtttaaact taagcttggt      720

accgagctcg gatccactag tccagtgtgg tggaattctg cagctcgcat ctctccttca      780

cgcgcccgcc gccctacctg aggccgccat ccacgccggt tgagtcgcgt tctgccgcct      840

cccgcctgtg gtgcctcctg aactgcgtcc gccgtctagg taagtttaaa gctcaggtcg      900

agaccgggcc tttgtccggc gctcccttgg agcctaccta gactcagccg gctctccacg      960

ctttgcctga ccctgcttgc tcaactctag gtaagttaat gagacagata gaaactggtc     1020

ttgtagaaac agagtagtcg cctgcttttc tgccaggtgc tgacttctct cccctgggct     1080

tttttctttt tctcaggttg aaaagaagaa gacgaagaag acgaagaaga caaaccgtcg     1140

tcgactgcca tgcgccgctg attaacgccg ccaccatggc ccaccgacgc agatccagaa     1200

gctgccgtga ggaccagaag cccgtgatgg atgatcagag ggaccttatc tctaacaatg     1260

aacaactgcc aatgctcggc agacggcctg gggccccgga gagcaagtgc agcagaggag     1320

ccttgtacac ggggttctcc attttagtga ctctccttct cgccggccaa gctaccaccg     1380

cctactttct gtaccaacag caaggcagac tagacaaact gacaatcaca agccagaacc     1440

ttcagctgga gtctctgcgg atgaagctgc ccgctttgtg gatgagattg cttcctctac     1500

ttgctctcct ggcgctctgg ggacctgacc ccgagcaaga gtttgttaat cagcacctgt     1560

gtgggagtca tctggtggag gcactctatt tagtgtgcgg agagaggggc ttcttctaca     1620

ctccaaagac cagacgggag gccgaagacc ttcaagtggg gcaagtagaa ctgggtggcg     1680

gacccggtgc cgggagcctt cagccgctcg ccctggaggg ctctcttcag aaacgcggca     1740

tcgtggagca gtgttgcaca tccatttgct cactctacca gctggagaac tactgcaacg     1800

gaagcggagt gaagcagacg ttgaattttg atttgttgaa gttggcgggg gatgtggaga     1860

gcaatccggg gccgatgccc cctagtggcc tcagactttt gttattgtta ttaccgcttt     1920

tatggctctt ggtgctgaca ccgggccgtc cggctgctgg cttgtcgact tgtaagacaa     1980

ttgatatgga attggtgaaa cgaaaacgga ttgaggccat ccgaggacag attttgagca     2040

agctgcggct tgcctcgcca ccctcgcaag gggaagtccc acccggacct ctaccagaag     2100

cagtcctagc gctgtacaac agtacaagag atagagtggc cggggaatcc gcagaaccag     2160

agcctgagcc tgaagccgat tattatgcaa aggaagtgac tagggtcctg atggtcgaga     2220

cccataacga aatctacgac aaattcaaac aaagtaccca ctctatctac atgttcttca     2280

acaccagtga gctaagagaa gccgtgcccg aacctgtgct tctttcccgc gcagaactcc     2340

gcctcttgag actcaaattg aaagttgaac aacacgtaga gctttaccag aaatactcta     2400

ataattcatg gcgatatctt tctaatcgtc tcctcgcccc atctgacagc cctgaatggc     2460

tctccttcga cgttacggga gttgtgcgcc agtggctcag cagaggcgga gagatagagg     2520

gctttcggct gagcgcacat agctctagcg actcaaggga caacacattg caagtggata     2580

ttaacggttt tacaactgga cggagagggg acctggcgac catccacggc atgaatagac     2640

ctttcctgct gctgatggct actcccctgg agagggcaca gcacttacag tcttccagac     2700

accggcgcgc cctggataca aactactgct tcagctccac cgaaaagaac tgttgcgtgc     2760

ggcagctgta cattgacttc agaaaggatc tgggctggaa gtggattcat gagcccaagg     2820

ggtatcatgc caacttctgt cttgggccat gcccatacat ctggtcactg gatacccagt     2880

actccaaagt tctggccttg tacaatcaac acaaccctgg agcttccgcc gctccttgct     2940

gtgtgcccca agccctagag cccctgccca tcgtttatta tgtcggacgc aagcccaaag     3000

tagaacagct atcaaatatg atcgtgagaa gctgcaagtg tagctgataa acgcgtcgag     3060

catgcatcta gggcggccaa ttccgcccct ctccccccca cccctctccc tccccccccc     3120

ctaacgttac tggccgaagc cgcttggaat aaggccggtg tgcgtttgtc tatatgttat     3180

tttccaccat attgccgtct tttggcaatg tgagggcccg gaaacctggc cctgtcttct     3240

tgacgagcat tcctaggggt ctttcccctc tcgccaaagg aatgcaaggt ctgttgaatg     3300

tcgtgaagga agcagttcct ctggaagctt cttgaagaca aacaacgtct gtagcgaccc     3360

tttgtagaca gcggaacccc ccacctggcg atagatgcct ctgcggccaa aagccacgtg     3420

tataagatac acctgcaaag gcggcacaac cccagtgcca cgttgtgagt tggatagttg     3480

tggaaagagt caaatggctc tcctcaagcg tattcaacaa ggggctgaag gatgcccaga     3540

aggtacccca ttgtatggga tctgatctgg ggcctcggtg cacatgcttt acatgtgttt     3600

agtcgaggtt aaaaaacgtc taggcccccc gaaccacggg gacgtggttt tcctttgaaa     3660

aacacgatga taatatgatg cacagctcag cactgctctg ttgcctggtc ctcctgactg     3720

gggtgagggc cagcccaggc cagggcaccc agtctgagaa cagctgcacc cacttcccag     3780

gcaacctgcc taacatgctt cgagatctcc gagatgcctt cagcagagtg aagactttct     3840

ttcaaatgaa ggatcagctg gacaacttgt tgttaaagga gtccttgctg gaggacttta     3900

agggttacct gggttgccaa gccttgtctg agatgatcca gttttacctg gaggaggtga     3960

tgccccaagc tgagaaccaa gacccagaca tcaaggcgca tgtgaactcc ctgggggaga     4020

acctgaagac cctcaggctg aggctacggc gctgtcatcg atttcttccc tgtgaaaaca     4080

agagcaaggc cgtggagcag gtgaagaatg cctttaataa gctccaagag aaaggcatct     4140

acaaagccat gagtgagttt gacatcttca tcaactacat agaagcctac atgacaatga     4200

agatacgaaa cgggagcggc gctactaact tcagcctgct gaagcaggct ggagacgtgg     4260

aggagaaccc tggacctatg tacagaatgc agctgctgag ctgcatcgcc ctgagcctgg     4320

ccctggtgac caacagcgca cccacgtcct ctagcaccaa gaagacccag ttacagttgg     4380

agcatctact tttagacctg caaatgattt tgaacggcat caacaactac aagaatccta     4440

aacttactcg catgcttacc ttcaaatttt acatgcccaa gaaggccacc gaactgaagc     4500

acttgcaatg tctggaggaa gaactcaagc cgctggagga agttctcaac ctcgcgcagt     4560

ccaagaattt ccacctccgg ccaagagacc tgatcagtaa cattaatgtg atagtgctgg     4620

agctgaaggg aagcgagact acatttatgt gcgagtacgc cgatgaaacc gctacaatcg     4680

tcgagttcct gaatagatgg atcacatttt gccagtcaat tatctctact ctgacatgat     4740

aactcgagtc tagagggccc gtttaaaccc gctgatcagc ctcgactgtg ccttctagtt     4800

gccagccatc tgttgtttgc ccctcccccg tgccttcctt gaccctggaa ggtgccactc     4860

ccactgtcct ttcctaataa aatgaggaaa ttgcatcgca ttgtctgagt aggtgtcatt     4920

ctattctggg gggtggggtg gggcaggaca gcaaggggga ggattgggaa gacaatagca     4980

ggcatgctgg ggatgcggtg ggctctatgg cttctactgg gcggttttat ggacagcaag     5040

cgaaccggaa ttgccagctg gggcgccctc tggtaaggtt gggaagccct gcaaagtaaa     5100

ctggatggct ttctcgccgc caaggatctg atggcgcagg ggatcaagct ctgatcaaga     5160

gacaggatga ggatcgtttc gcatggccaa agaagacaat attgaaatgc aaggtaccgt     5220

tcttgaaacg ttgcctaata ccatgttccg cgtagagtta gaaaacggtc acgtggttac     5280

tgcacacatc tccggtaaaa tgcgcaaaaa ctacatccgc atcctgacgg gcgacaaagt     5340

gactgttgaa ctgaccccgt acgacctgag caaaggccgc attgtcttcc gtagtcgctg     5400

ataaattatt aacgcttaca atttcctgat gcggtatttt ctccttacgc atctgtgcgg     5460

tatttcacac cgcatacagg tggcactttt cggggaaatg tgcgcggaac ccctatttgt     5520

ttatttttct aaatacattc aaatatgtat ccgctcatga gacaataacc ctgataaatg     5580

cttcaataat agcacgtgct aaaacttcat ttttaattta aaaggatcta ggtgaagatc     5640

ctttttgata atctcatgac caaaatccct taacgtgagt tttcgttcca ctgagcgtca     5700

gaccccgtag aaaagatcaa aggatcttct tgagatcctt tttttctgcg cgtaatctgc     5760

tgcttgcaaa caaaaaaacc accgctacca gcggtggttt gtttgccgga tcaagagcta     5820

ccaactcttt ttccgaaggt aactggcttc agcagagcgc agataccaaa tactgttctt     5880

ctagtgtagc cgtagttagg ccaccacttc aagaactctg tagcaccgcc tacatacctc     5940

gctctgctaa tcctgttacc agtggctgct gccagtggcg ataagtcgtg tcttaccggg     6000

ttggactcaa gacgatagtt accggataag gcgcagcggt cgggctgaac ggggggttcg     6060

tgcacacagc ccagcttgga gcgaacgacc tacaccgaac tgagatacct acagcgtgag     6120

ctatgagaaa gcgccacgct tcccgaaggg agaaaggcgg acaggtatcc ggtaagcggc     6180

agggtcggaa caggagagcg cacgagggag cttccagggg gaaacgcctg gtatctttat     6240

agtcctgtcg ggtttcgcca cctctgactt gagcgtcgat ttttgtgatg ctcgtcaggg     6300

gggcggagcc tatggaaaaa cgccagcaac gcggcctttt tacggttcct gggcttttgc     6360

tggccttttg ctcacatgtt ctt                                             6383


