                         SEQUENCE LISTING

<110>  GlaxoSmithKline Intellectual Property (No.2) Limited
 
<120>  BINDING PROTEINS

<130>  PB66217 WO

<150>  US62/416215
<151>  2016-11-02

<150>  US62/416217
<151>  2016-11-02

<150>  US62/416218
<151>  2016-11-02

<160>  81    

<170>  PatentIn version 3.5

<210>  1
<211>  120
<212>  PRT
<213>  Artificial

<220>
<223>  Heavy chain variable domain of clone 37Y056-57E02-1

<400>  1

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Gly Tyr 
            20                  25                  30          


Tyr Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Asn Pro Asn Ser Gly Gly Thr Asn Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Met Thr Arg Asp Thr Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Arg Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Glu Gly Pro Tyr Asp Asp Asp Gly Phe Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser 
        115                 120 


<210>  2
<211>  106
<212>  PRT
<213>  Artificial

<220>
<223>  Light chain variable domain of clone 37Y056-57E02-1

<400>  2

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Val Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Ser Ser Trp 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Glu Thr Asn Ser Phe Trp Thr 
                85                  90                  95      


Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105     


<210>  3
<211>  122
<212>  PRT
<213>  Artificial

<220>
<223>  Heavy chain variable domain of clone 22D034-51A09-188001

<400>  3

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Arg Thr His 
            20                  25                  30          


Tyr Met Val Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Phe Ile Gly Pro Ala Gly Asp Thr Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Tyr Thr Ala Thr Ser Gly Val Asp Thr Tyr Asp Val Met Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser Ala 
        115                 120         


<210>  4
<211>  5
<212>  PRT
<213>  Artificial

<220>
<223>  CDRH1 LAG3, Kabat definition

<400>  4

Gly Tyr Tyr Met His 
1               5   


<210>  5
<211>  17
<212>  PRT
<213>  Artificial

<220>
<223>  CDRH2 LAG3, Kabat definition

<400>  5

Trp Ile Asn Pro Asn Ser Gly Gly Thr Asn Tyr Ala Gln Lys Phe Gln 
1               5                   10                  15      


Gly 
    


<210>  6
<211>  11
<212>  PRT
<213>  Artificial

<220>
<223>  CDRH3 LAG3, Kabat definition

<400>  6

Glu Gly Pro Tyr Asp Asp Asp Gly Phe Asp Tyr 
1               5                   10      


<210>  7
<211>  11
<212>  PRT
<213>  Artificial

<220>
<223>  CDRL1 LAG3, Kabat definition

<400>  7

Arg Ala Ser Gln Gly Ile Ser Ser Trp Leu Ala 
1               5                   10      


<210>  8
<211>  7
<212>  PRT
<213>  Artificial

<220>
<223>  CDRL2 LAG3, Kabat definition

<400>  8

Ala Ala Ser Ser Leu Gln Ser 
1               5           


<210>  9
<211>  8
<212>  PRT
<213>  Artificial

<220>
<223>  CDRL3 LAG3, Kabat definition

<400>  9

Gln Glu Thr Asn Ser Phe Trp Thr 
1               5               


<210>  10
<211>  5
<212>  PRT
<213>  Artificial

<220>
<223>  CDRH1 (Kabat definition) of clone 
       22D034-51A09-/188/183/140/135/126/110/109/73/55/54/30/16/13/10/4

<400>  10

Thr His Tyr Met Val 
1               5   


<210>  11
<211>  17
<212>  PRT
<213>  Artificial

<220>
<223>  CDRH2 (Kabat definition) of clones 22D034-51A09-188, 
       22D034-51A09-140, 22D034-51A09-109, 22D034-51A09-73, 
       22D034-51A09-30 and 22D034-51A09-13

<400>  11

Phe Ile Gly Pro Ala Gly Asp Thr Thr Tyr Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  12
<211>  12
<212>  PRT
<213>  Artificial

<220>
<223>  CDRH3 ( Kabat definition) of clones 22D034-51A09-188, 
       22D034-51A09-183, 22D034-51A09-110, 22D034-51A09-109, 
       22D034-51A09-73, 22D034-51A09-30, 22D034-51A09-13 and 
       22D034-51A09-4

<400>  12

Tyr Thr Ala Thr Ser Gly Val Asp Thr Tyr Asp Val 
1               5                   10          


<210>  13
<211>  7
<212>  PRT
<213>  Artificial

<220>
<223>  CDRH1 LAG-3, Chothia definition

<400>  13

Gly Tyr Thr Phe Thr Gly Tyr 
1               5           


<210>  14
<211>  6
<212>  PRT
<213>  Artificial

<220>
<223>  CDRH2 LAG-3, Chothia definition

<400>  14

Asn Pro Asn Ser Gly Gly 
1               5       


<210>  15
<211>  7
<212>  PRT
<213>  Artificial

<220>
<223>  CDRH1 PD-1, Chothia definition

<400>  15

Gly Phe Thr Phe Arg Thr His 
1               5           


<210>  16
<211>  6
<212>  PRT
<213>  Artificial

<220>
<223>  CDRH2 PD-1, Chothia definition

<400>  16

Gly Pro Ala Gly Asp Thr 
1               5       


<210>  17
<211>  10
<212>  PRT
<213>  Artificial

<220>
<223>  CDRH1 LAG-3, AbM definition

<400>  17

Gly Tyr Thr Phe Thr Gly Tyr Tyr Met His 
1               5                   10  


<210>  18
<211>  10
<212>  PRT
<213>  Artificial

<220>
<223>  CDRH2 LAG-3, AbM definition

<400>  18

Trp Ile Asn Pro Asn Ser Gly Gly Thr Asn 
1               5                   10  


<210>  19
<211>  10
<212>  PRT
<213>  Artificial

<220>
<223>  CDRH1 PD-1, AbM definition

<400>  19

Gly Phe Thr Phe Arg Thr His Tyr Met Val 
1               5                   10  


<210>  20
<211>  10
<212>  PRT
<213>  Artificial

<220>
<223>  CDRH2 PD-1, AbM definition

<400>  20

Phe Ile Gly Pro Ala Gly Asp Thr Thr Tyr 
1               5                   10  


<210>  21
<211>  6
<212>  PRT
<213>  Artificial

<220>
<223>  CDRH1 LAG-3, Contact definition

<400>  21

Thr Gly Tyr Tyr Met His 
1               5       


<210>  22
<211>  13
<212>  PRT
<213>  Artificial

<220>
<223>  CDRH2 LAG-3, Contact definition

<400>  22

Trp Met Gly Trp Ile Asn Pro Asn Ser Gly Gly Thr Asn 
1               5                   10              


<210>  23
<211>  12
<212>  PRT
<213>  Artificial

<220>
<223>  CDRH3 LAG-3, Contact definition

<400>  23

Ala Arg Glu Gly Pro Tyr Asp Asp Asp Gly Phe Asp 
1               5                   10          


<210>  24
<211>  7
<212>  PRT
<213>  Artificial

<220>
<223>  CDRL1 LAG-3, Contact definition

<400>  24

Ser Ser Trp Leu Ala Trp Tyr 
1               5           


<210>  25
<211>  10
<212>  PRT
<213>  Artificial

<220>
<223>  CDRL2 LAG-3, Contact definition

<400>  25

Leu Leu Ile Tyr Ala Ala Ser Ser Leu Gln 
1               5                   10  


<210>  26
<211>  7
<212>  PRT
<213>  Artificial

<220>
<223>  CDRL3 LAG-3, Contact definition

<400>  26

Gln Glu Thr Asn Ser Phe Trp 
1               5           


<210>  27
<211>  6
<212>  PRT
<213>  Artificial

<220>
<223>  CDRH1 PD-1, Contact definition

<400>  27

Arg Thr His Tyr Met Val 
1               5       


<210>  28
<211>  13
<212>  PRT
<213>  Artificial

<220>
<223>  CDRH2 PD-1, Contact definition

<400>  28

Trp Val Ser Phe Ile Gly Pro Ala Gly Asp Thr Thr Tyr 
1               5                   10              


<210>  29
<211>  13
<212>  PRT
<213>  Artificial

<220>
<223>  CDRH3 PD-1, Contact definition

<400>  29

Ala Ala Tyr Thr Ala Thr Ser Gly Val Asp Thr Tyr Asp 
1               5                   10              


<210>  30
<211>  8
<212>  PRT
<213>  Artificial

<220>
<223>  Linker sequence

<400>  30

Ser Thr Gly Leu Asp Ser Pro Thr 
1               5               


<210>  31
<211>  5
<212>  PRT
<213>  Artificial

<220>
<223>  CDRH1 (Kabat definition) of clone 22D034-51A09-163

<400>  31

Thr His Tyr Met Ala 
1               5   


<210>  32
<211>  17
<212>  PRT
<213>  Artificial

<220>
<223>  CDRH2 (Kabat definition) of clone 
       22D034-51A09-/183/135/110/54/10/4

<400>  32

Phe Ile Gly Pro Ala Gly Asp Phe Thr Tyr Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  33
<211>  17
<212>  PRT
<213>  Artificial

<220>
<223>  CDRH2 (Kabat definition) of clones 22D034-51A09-163, 
       22D034-51A09-126 and 22D034-51A09-16

<400>  33

Phe Ile Gly Pro Ala Gly Asp Ser Thr Tyr Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  34
<211>  17
<212>  PRT
<213>  Artificial

<220>
<223>  CDRH2 (Kabat definition) of clone 22D034-51A09-55

<400>  34

Phe Ile Gly Pro Ala Gly Asp Phe Thr Tyr Tyr Ala Asp Ser Val Glu 
1               5                   10                  15      


Gly 
    


<210>  35
<211>  12
<212>  PRT
<213>  Artificial

<220>
<223>  CDRH3 (Kabat definition) of clone 22D034-51A09-163

<400>  35

Tyr Thr Ala Thr Ser Ser Val Asp Thr Tyr Asp Val 
1               5                   10          


<210>  36
<211>  12
<212>  PRT
<213>  Artificial

<220>
<223>  CDRH3 (Kabat definition) of clones 22D034-51A09-140 and 
       22D034-51A09-10

<400>  36

Tyr Thr Ala Thr Ser Asp Val Asp Thr Tyr Asp Val 
1               5                   10          


<210>  37
<211>  12
<212>  PRT
<213>  Artificial

<220>
<223>  CDRH3 (Kabat definition) of clone 22D034-51A09-135

<400>  37

Tyr Thr Glu Thr Ser Gly Val Asp Thr Tyr Asp Val 
1               5                   10          


<210>  38
<211>  12
<212>  PRT
<213>  Artificial

<220>
<223>  CDRH3 (Kabat definition) of clones 22D034-51A09-126 and 
       22D034-51A09-55

<400>  38

Tyr Thr Ala Thr Ser Gly Phe Asp Thr Tyr Asp Val 
1               5                   10          


<210>  39
<211>  12
<212>  PRT
<213>  Artificial

<220>
<223>  CDRH3 (Kabat definition) of clone 22D034-51A09-54

<400>  39

Tyr Thr Ala Thr Ser Gly Tyr Asp Thr Tyr Asp Val 
1               5                   10          


<210>  40
<211>  12
<212>  PRT
<213>  Artificial

<220>
<223>  CDRH3 (Kabat definition) of clone 22D034-51A09-16

<400>  40

Tyr Thr Ala Thr Ser Gly Phe Asp Ser Tyr Asp Val 
1               5                   10          


<210>  41
<211>  11
<212>  PRT
<213>  Artificial

<220>
<223>  CDRL1 Kabat definition) of clone 57C06

<400>  41

Arg Ala Ser Gln Ser Ile Ser Ser Phe Leu Asn 
1               5                   10      


<210>  42
<211>  11
<212>  PRT
<213>  Artificial

<220>
<223>  CDRL1 Kabat definition) of clone 57H08

<400>  42

Arg Ala Ser Gln Ser Ile Ser Ser Tyr Leu Asn 
1               5                   10      


<210>  43
<211>  8
<212>  PRT
<213>  Artificial

<220>
<223>  CDRL3 Kabat definition) of clone 57B02

<400>  43

Gln Gln Ala Val Asp His Phe Thr 
1               5               


<210>  44
<211>  9
<212>  PRT
<213>  Artificial

<220>
<223>  CDRL3 Kabat definition) of clone 57C06

<400>  44

Gln Asp Leu Tyr Ser Thr Pro Leu Thr 
1               5                   


<210>  45
<211>  10
<212>  PRT
<213>  Artificial

<220>
<223>  CDRL3 Kabat definition) of clone 57H08

<400>  45

Gln Gln Ser Phe Pro Ala Pro Pro Tyr Thr 
1               5                   10  


<210>  46
<211>  57
<212>  DNA
<213>  Artificial

<220>
<223>  forward primer oligonucleotide

<400>  46
cccggaaagg gatccacagg actggactcc ccgacagagg tgcagctgtt ggagtct          57


<210>  47
<211>  41
<212>  DNA
<213>  Artificial

<220>
<223>  reverse primer oligonucleotide

<400>  47
ggggatctag aattcatcag ctcgagacgg tgaccagggt t                           41


<210>  48
<211>  25
<212>  DNA
<213>  Artificial

<220>
<223>  forward primer oligonucleotide

<400>  48
ggccaccgcc accggtgtgc acagc                                             25


<210>  49
<211>  16
<212>  DNA
<213>  Artificial

<220>
<223>  reverse primer oligonucleotide

<400>  49
cgtacggtgg ccgccc                                                       16


<210>  50
<211>  213
<212>  PRT
<213>  Artificial

<220>
<223>  Amino acid sequence of light chain of LAG-3 mAb 57E02 and 
       PD-1/LAG-3 mAbdAb 57E02x51A09-188001)

<400>  50

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Val Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Ser Ser Trp 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Glu Thr Asn Ser Phe Trp Thr 
                85                  90                  95      


Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala Ala Pro 
            100                 105                 110         


Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly Thr 
        115                 120                 125             


Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala Lys 
    130                 135                 140                 


Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln Glu 
145                 150                 155                 160 


Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser Ser 
                165                 170                 175     


Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr Ala 
            180                 185                 190         


Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser Phe 
        195                 200                 205             


Asn Arg Gly Glu Cys 
    210             


<210>  51
<211>  639
<212>  DNA
<213>  Artificial

<220>
<223>  DNA sequence of light chain of LAG-3 mAb 57E02 and PD-1/LAG-3 
       mAbdAb 57E02x51A09-188001

<400>  51
gacatccaga tgacccagag ccccagctca gtgagcgcta gcgtgggcga cagggtgacc       60

atcacctgca gggccagcca gggcattagc agctggctgg cctggtacca gcagaagccc      120

ggcaaggccc ccaagctcct gatctacgcc gccagcagcc tgcagagcgg cgtgccctcc      180

aggtttagcg gcagcggaag cggcaccgac ttcaccctga ccatcagcag cctgcagccc      240

gaggacttcg ccacctacta ctgccaggag accaacagct tctggacctt cggcggcggc      300

acaaaagtcg agatcaagcg tacggtggcc gcccccagcg tgttcatctt cccccccagc      360

gatgagcagc tgaagagcgg caccgccagc gtggtgtgtc tgctgaacaa cttctacccc      420

cgggaggcca aggtgcagtg gaaggtggac aatgccctgc agagcggcaa cagccaggag      480

agcgtgaccg agcaggacag caaggactcc acctacagcc tgagcagcac cctgaccctg      540

agcaaggccg actacgagaa gcacaaggtg tacgcctgtg aggtgaccca ccagggcctg      600

tccagccccg tgaccaagag cttcaaccgg ggcgagtgc                             639


<210>  52
<211>  450
<212>  PRT
<213>  Artificial

<220>
<223>  Amino acid sequence of heavy chain of LAG-3 mAb 57E02

<400>  52

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Gly Tyr 
            20                  25                  30          


Tyr Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Asn Pro Asn Ser Gly Gly Thr Asn Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Met Thr Arg Asp Thr Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Arg Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Glu Gly Pro Tyr Asp Asp Asp Gly Phe Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val 
        115                 120                 125             


Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala 
    130                 135                 140                 


Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser 
145                 150                 155                 160 


Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val 
                165                 170                 175     


Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro 
            180                 185                 190         


Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys 
        195                 200                 205             


Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp 
    210                 215                 220                 


Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Ala Gly Ala 
225                 230                 235                 240 


Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile 
                245                 250                 255     


Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu 
            260                 265                 270         


Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His 
        275                 280                 285             


Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg 
    290                 295                 300                 


Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys 
305                 310                 315                 320 


Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu 
                325                 330                 335     


Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr 
            340                 345                 350         


Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu 
        355                 360                 365             


Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp 
    370                 375                 380                 


Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val 
385                 390                 395                 400 


Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp 
                405                 410                 415     


Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His 
            420                 425                 430         


Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro 
        435                 440                 445             


Gly Lys 
    450 


<210>  53
<211>  1350
<212>  DNA
<213>  Artificial

<220>
<223>  DNA sequence of heavy chain of LAG-3 mAb 57E02

<400>  53
caggtgcagc tcgtgcagag cggcgccgag gtgaaaaagc ccggcgcctc tgtcaaggtg       60

agctgcaagg ccagcggcta caccttcacc ggctactaca tgcactgggt gaggcaggct      120

cccggacagg gcctggagtg gatgggctgg atcaacccca acagcggcgg caccaactac      180

gcccagaagt tccagggcag ggtgaccatg accagggaca ccagcatcag caccgcctac      240

atggaactga gcaggctgag gagcgacgac accgccgtgt attactgcgc cagggaggga      300

ccctacgacg acgacggctt cgactactgg ggccagggca ccctggtgac agtgagcagc      360

gccagcacca agggccccag cgtgttcccc ctggccccca gcagcaagag caccagcggc      420

ggcacagccg ccctgggctg cctggtgaag gactacttcc ccgagcccgt gaccgtgtcc      480

tggaacagcg gagccctgac cagcggcgtg cacaccttcc ccgccgtgct gcagagcagc      540

ggcctgtaca gcctgagcag cgtggtgacc gtgcccagca gcagcctggg cacccagacc      600

tacatctgta acgtgaacca caagcccagc aacaccaagg tggacaagaa ggtggagccc      660

aagagctgtg acaagaccca cacctgcccc ccctgccctg cccccgagct ggccggagcc      720

cccagcgtgt tcctgttccc ccccaagcct aaggacaccc tgatgatcag cagaaccccc      780

gaggtgacct gtgtggtggt ggatgtgagc cacgaggacc ctgaggtgaa gttcaactgg      840

tacgtggacg gcgtggaggt gcacaatgcc aagaccaagc ccagggagga gcagtacaac      900

agcacctacc gggtggtgtc cgtgctgacc gtgctgcacc aggattggct gaacggcaag      960

gagtacaagt gtaaggtgtc caacaaggcc ctgcctgccc ctatcgagaa aaccatcagc     1020

aaggccaagg gccagcccag agagccccag gtgtacaccc tgccccctag cagagatgag     1080

ctgaccaaga accaggtgtc cctgacctgc ctggtgaagg gcttctaccc cagcgacatc     1140

gccgtggagt gggagagcaa cggccagccc gagaacaact acaagaccac cccccctgtg     1200

ctggacagcg atggcagctt cttcctgtac agcaagctga ccgtggacaa gagcagatgg     1260

cagcagggca acgtgttcag ctgctccgtg atgcacgagg ccctgcacaa tcactacacc     1320

cagaagagcc tgagcctgtc ccctggcaag                                      1350


<210>  54
<211>  581
<212>  PRT
<213>  Artificial

<220>
<223>  Amino acid sequence of heavy chain of PD-1/LAG-3 mAbdAb 
       57E02x51A09-188001

<400>  54

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Gly Tyr 
            20                  25                  30          


Tyr Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Asn Pro Asn Ser Gly Gly Thr Asn Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Met Thr Arg Asp Thr Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Arg Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Glu Gly Pro Tyr Asp Asp Asp Gly Phe Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val 
        115                 120                 125             


Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala 
    130                 135                 140                 


Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser 
145                 150                 155                 160 


Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val 
                165                 170                 175     


Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro 
            180                 185                 190         


Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys 
        195                 200                 205             


Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp 
    210                 215                 220                 


Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Ala Gly Ala 
225                 230                 235                 240 


Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile 
                245                 250                 255     


Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu 
            260                 265                 270         


Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His 
        275                 280                 285             


Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg 
    290                 295                 300                 


Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys 
305                 310                 315                 320 


Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu 
                325                 330                 335     


Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr 
            340                 345                 350         


Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu 
        355                 360                 365             


Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp 
    370                 375                 380                 


Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val 
385                 390                 395                 400 


Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp 
                405                 410                 415     


Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His 
            420                 425                 430         


Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro 
        435                 440                 445             


Gly Lys Gly Ser Thr Gly Leu Asp Ser Pro Thr Glu Val Gln Leu Leu 
    450                 455                 460                 


Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser 
465                 470                 475                 480 


Cys Ala Ala Ser Gly Phe Thr Phe Arg Thr His Tyr Met Val Trp Val 
                485                 490                 495     


Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ser Phe Ile Gly Pro 
            500                 505                 510         


Ala Gly Asp Thr Thr Tyr Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr 
        515                 520                 525             


Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser 
    530                 535                 540                 


Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Ala Tyr Thr Ala 
545                 550                 555                 560 


Thr Ser Gly Val Asp Thr Tyr Asp Val Met Gly Gln Gly Thr Leu Val 
                565                 570                 575     


Thr Val Ser Ser Ala 
            580     


<210>  55
<211>  1743
<212>  DNA
<213>  Artificial

<220>
<223>  DNA sequence of heavy chain of PD-1/LAG-3 mAbdAb 
       57E02x51A09-188001

<400>  55
caggtgcagc tggtgcagag cggggccgag gtgaagaaac ccggcgctag cgtcaaggtg       60

agctgcaagg ccagcgggta caccttcacc ggctactaca tgcactgggt gaggcaggcc      120

cccggccagg gactcgagtg gatggggtgg atcaacccca acagcggcgg cacaaactac      180

gcccagaagt ttcagggcag ggtgaccatg accagggaca ccagcatcag caccgcctac      240

atggaactca gcaggctgag gtccgacgac accgccgtgt actattgcgc cagggaggga      300

ccatacgacg acgacggctt cgattactgg ggccagggca ccctggtgac cgtgagcagc      360

gccagcacca agggccccag cgtgttcccc ctggccccca gcagcaagag caccagcggc      420

ggcacagccg ccctgggctg cctggtgaag gactacttcc ccgagcccgt gaccgtgtcc      480

tggaacagcg gagccctgac cagcggcgtg cacaccttcc ccgccgtgct gcagagcagc      540

ggcctgtaca gcctgagcag cgtggtgacc gtgcccagca gcagcctggg cacccagacc      600

tacatctgta acgtgaacca caagcccagc aacaccaagg tggacaagaa ggtggagccc      660

aagagctgtg acaagaccca cacctgcccc ccctgccctg cccccgagct ggccggagcc      720

cccagcgtgt tcctgttccc ccccaagcct aaggacaccc tgatgatcag cagaaccccc      780

gaggtgacct gtgtggtggt ggatgtgagc cacgaggacc ctgaggtgaa gttcaactgg      840

tacgtggacg gcgtggaggt gcacaatgcc aagaccaagc ccagggagga gcagtacaac      900

agcacctacc gggtggtgtc cgtgctgacc gtgctgcacc aggattggct gaacggcaag      960

gagtacaagt gtaaggtgtc caacaaggcc ctgcctgccc ctatcgagaa aaccatcagc     1020

aaggccaagg gccagcccag agagccccag gtgtacaccc tgccccctag cagagatgag     1080

ctgaccaaga accaggtgtc cctgacctgc ctggtgaagg gcttctaccc cagcgacatc     1140

gccgtggagt gggagagcaa cggccagccc gagaacaact acaagaccac cccccctgtg     1200

ctggacagcg atggcagctt cttcctgtac agcaagctga ccgtggacaa gagcagatgg     1260

cagcagggca acgtgttcag ctgctccgtg atgcacgagg ccctgcacaa tcactacacc     1320

cagaagagcc tgagcctgtc ccctggcaag ggatccaccg gcctggacag ccccaccgag     1380

gtccagttgc tggaaagtgg gggaggactg gtgcagcctg gcggaagcct tagactcagc     1440

tgcgccgcta gtggcttcac tttccgcacc cactacatgg tgtgggttag gcaggcaccc     1500

ggaaaaggtc tagagtgggt tagctttatc ggccctgccg gcgataccac ctattacgcc     1560

gattccgtga agggcaggtt cacaatcagc agggacaaca gcaagaacac cctgtacctg     1620

cagatgaact ccctcagggc tgaggacacc gcggtgtact actgtgctgc ctacaccgca     1680

acctcaggag tcgataccta cgacgtgatg ggacagggca ctttggttac cgtgagtagc     1740

gcc                                                                   1743


<210>  56
<211>  11
<212>  PRT
<213>  Artificial

<220>
<223>  Generic CDRL1 LAG3, Kabat definition


<220>
<221>  VARIANT
<222>  (5)..(5)
<223>  X = "G" or "S"

<220>
<221>  VARIANT
<222>  (9)..(9)
<223>  X = "F" or "W" or "Y"

<220>
<221>  VARIANT
<222>  (11)..(11)
<223>  X = "A" or "N"

<400>  56

Arg Ala Ser Gln Xaa Ile Ser Ser Xaa Leu Xaa 
1               5                   10      


<210>  57
<211>  5
<212>  PRT
<213>  Artificial

<220>
<223>  Generic CDRH1 PD-1, Kabat definition


<220>
<221>  VARIANT
<222>  (5)..(5)
<223>  X = "V" or "A"

<400>  57

Thr His Tyr Met Xaa 
1               5   


<210>  58
<211>  17
<212>  PRT
<213>  Artificial

<220>
<223>  Generic CDRH2 PD-1, Kabat definition


<220>
<221>  VARIANT
<222>  (8)..(8)
<223>  X = "T" or "F" or "S"

<220>
<221>  VARIANT
<222>  (16)..(16)
<223>  X = "K" or "E"

<400>  58

Phe Ile Gly Pro Ala Gly Asp Xaa Thr Tyr Tyr Ala Asp Ser Val Xaa 
1               5                   10                  15      


Gly 
    


<210>  59
<211>  12
<212>  PRT
<213>  Artificial

<220>
<223>  Generic CDRH3 PD-1, Kabat definition


<220>
<221>  VARIANT
<222>  (3)..(3)
<223>  X = "A" or "E"

<220>
<221>  VARIANT
<222>  (6)..(6)
<223>  X = "G" or "S" or "D"

<220>
<221>  VARIANT
<222>  (7)..(7)
<223>  X = "V" or "F" or "Y"

<220>
<221>  VARIANT
<222>  (9)..(9)
<223>  X = "T" or "S"

<400>  59

Tyr Thr Xaa Thr Ser Xaa Xaa Asp Xaa Tyr Asp Val 
1               5                   10          


<210>  60
<211>  22
<212>  DNA
<213>  Artificial

<220>
<223>  HIV-1 Gag forward primer

<400>  60
atcaagcagc tatgcaaatg tt                                                22


<210>  61
<211>  29
<212>  DNA
<213>  Artificial

<220>
<223>  HIV-1 Gag probe

<400>  61
accatcaatg aggaagctgc agaatggga                                         29


<210>  62
<211>  30
<212>  DNA
<213>  Artificial

<220>
<223>  HIV-1 Gag reverse primer

<400>  62
ctgaagggta ctagtagttc ctgctatgtc                                        30


<210>  63
<211>  4
<212>  PRT
<213>  Artificial

<220>
<223>  C-terminal extension to epitope binding domain or single variable
       domain when n is 0 and  X11 is absent

<400>  63

Val Thr Val Ser 
1               


<210>  64
<211>  5
<212>  PRT
<213>  Artificial

<220>
<223>  C-terminal extension to epitope binding domain or single variable
       domain when n is 1 and  X11 is absent

<400>  64

Val Thr Val Ser Ser 
1               5   


<210>  65
<211>  12
<212>  PRT
<213>  Artificial

<220>
<223>  C-terminal extension to epitope binding domain or single variable
       domain when n is 0 and  X11 is present


<220>
<221>  PEPTIDE
<222>  (5)..(12)
<223>  Peptide may terminate at position 6,7,8,9,10,11 or 12.  Peptide 
       from 5 to 12 may  include the following sequences: A, AAA or T.

<400>  65

Val Thr Val Ser Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
1               5                   10          


<210>  66
<211>  13
<212>  PRT
<213>  Artificial

<220>
<223>  C-terminal extension to epitope binding domain or single variable
       domain when n is 1 and  X11 is present


<220>
<221>  PEPTIDE
<222>  (6)..(13)
<223>  Peptide may terminate at position 7,8,9,10,11,12. or 13  Peptide 
       from 6 to 13 may  include the following sequences: A, AAA or T.

<400>  66

Val Thr Val Ser Ser Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
1               5                   10              


<210>  67
<211>  5
<212>  PRT
<213>  Artificial

<220>
<223>  C-terminal extension to epitope binding domain or single variable
       domain when n is 0 and  X11 is A

<400>  67

Val Thr Val Ser Ala 
1               5   


<210>  68
<211>  6
<212>  PRT
<213>  Artificial

<220>
<223>  C-terminal extension to epitope binding domain or single variable
       domain when n is 1 and  X11 is A

<400>  68

Val Thr Val Ser Ser Ala 
1               5       


<210>  69
<211>  6
<212>  PRT
<213>  Artificial

<220>
<223>  C-terminal extension to epitope binding domain or single variable
       domain when n is 0 and  X11 is AS

<400>  69

Val Thr Val Ser Ala Ser 
1               5       


<210>  70
<211>  7
<212>  PRT
<213>  Artificial

<220>
<223>  C-terminal extension to epitope binding domain or single variable
       domain when n is 1 and  X11 is AS

<400>  70

Val Thr Val Ser Ser Ala Ser 
1               5           


<210>  71
<211>  7
<212>  PRT
<213>  Artificial

<220>
<223>  C-terminal extension to epitope binding domain or single variable
       domain when n is 0 and  X11 is AST

<400>  71

Val Thr Val Ser Ala Ser Thr 
1               5           


<210>  72
<211>  8
<212>  PRT
<213>  Artificial

<220>
<223>  C-terminal extension to epitope binding domain or single variable
       domain when n is 1 and  X11 is AST

<400>  72

Val Thr Val Ser Ser Ala Ser Thr 
1               5               


<210>  73
<211>  7
<212>  PRT
<213>  Artificial

<220>
<223>  C-terminal extension to epitope binding domain or single variable
       domain when n is 0 and  X11 is ASTK

<400>  73

Val Thr Val Ser Ala Ser Thr 
1               5           


<210>  74
<211>  9
<212>  PRT
<213>  Artificial

<220>
<223>  C-terminal extension to epitope binding domain or single variable
       domain when n is 1 and  X11 is ASTK

<400>  74

Val Thr Val Ser Ser Ala Ser Thr Lys 
1               5                   


<210>  75
<211>  9
<212>  PRT
<213>  Artificial

<220>
<223>  C-terminal extension to epitope binding domain or single variable
       domain when n is 0 and  X11 is ASTKG

<400>  75

Val Thr Val Ser Ala Ser Thr Lys Gly 
1               5                   


<210>  76
<211>  10
<212>  PRT
<213>  Artificial

<220>
<223>  C-terminal extension to epitope binding domain or single variable
       domain when n is 1 and  X11 is ASTKG

<400>  76

Val Thr Val Ser Ser Ala Ser Thr Lys Gly 
1               5                   10  


<210>  77
<211>  10
<212>  PRT
<213>  Artificial

<220>
<223>  C-terminal extension to epitope binding domain or single variable
       domain when n is 0 and  X11 is ASTKGP

<400>  77

Val Thr Val Ser Ala Ser Thr Lys Gly Pro 
1               5                   10  


<210>  78
<211>  11
<212>  PRT
<213>  Artificial

<220>
<223>  C-terminal extension to epitope binding domain or single variable
       domain when n is 1 and  X11 is ASTKGP

<400>  78

Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro 
1               5                   10      


<210>  79
<211>  215
<212>  PRT
<213>  Artificial

<220>
<223>  Amino acid sequence of light chain of CTLA-4/PD-1 mAbdAb 
       CTLA4x51A09-188001

<400>  79

Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Gly Ser Ser 
            20                  25                  30          


Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu 
        35                  40                  45              


Ile Tyr Gly Ala Phe Ser Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu 
65                  70                  75                  80  


Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Gly Ser Ser Pro 
                85                  90                  95      


Trp Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala 
            100                 105                 110         


Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser 
        115                 120                 125             


Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu 
    130                 135                 140                 


Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser 
145                 150                 155                 160 


Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu 
                165                 170                 175     


Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val 
            180                 185                 190         


Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys 
        195                 200                 205             


Ser Phe Asn Arg Gly Glu Cys 
    210                 215 


<210>  80
<211>  579
<212>  PRT
<213>  Artificial

<220>
<223>  Amino acid sequence of heavy chain of CTLA-4/PD-1 mAbdAb 
       CTLA4x51A09-188001

<400>  80

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Thr Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Thr Phe Ile Ser Tyr Asp Gly Asn Asn Lys Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Ile Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Thr Gly Trp Leu Gly Pro Phe Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro 
        115                 120                 125             


Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly 
    130                 135                 140                 


Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn 
145                 150                 155                 160 


Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln 
                165                 170                 175     


Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser 
            180                 185                 190         


Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser 
        195                 200                 205             


Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr 
    210                 215                 220                 


His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Ala Gly Ala Pro Ser 
225                 230                 235                 240 


Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg 
                245                 250                 255     


Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro 
            260                 265                 270         


Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala 
        275                 280                 285             


Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val 
    290                 295                 300                 


Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr 
305                 310                 315                 320 


Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr 
                325                 330                 335     


Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu 
            340                 345                 350         


Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys 
        355                 360                 365             


Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser 
    370                 375                 380                 


Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp 
385                 390                 395                 400 


Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser 
                405                 410                 415     


Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala 
            420                 425                 430         


Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
        435                 440                 445             


Gly Ser Thr Gly Leu Asp Ser Pro Thr Glu Val Gln Leu Leu Glu Ser 
    450                 455                 460                 


Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala 
465                 470                 475                 480 


Ala Ser Gly Phe Thr Phe Arg Thr His Tyr Met Val Trp Val Arg Gln 
                485                 490                 495     


Ala Pro Gly Lys Gly Leu Glu Trp Val Ser Phe Ile Gly Pro Ala Gly 
            500                 505                 510         


Asp Thr Thr Tyr Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser 
        515                 520                 525             


Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg 
    530                 535                 540                 


Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Ala Tyr Thr Ala Thr Ser 
545                 550                 555                 560 


Gly Val Asp Thr Tyr Asp Val Met Gly Gln Gly Thr Leu Val Thr Val 
                565                 570                 575     


Ser Ser Ala 
            


<210>  81
<211>  7
<212>  PRT
<213>  Artificial

<220>
<223>  C-terminal sequence of 51A09-188001

<400>  81

Leu Val Thr Val Ser Ser Ala 
1               5           


