                         SEQUENCE LISTING

<110>  Rhode Island Hospital
 
<120>  GLYCOSYLATED TRANSFERRIN RECEPTOR 1 TUMOR ANTIGEN

<130>  21486-632001WO

<150>  62/414,662
<151>  2016-10-29

<150>  62/415,204
<151>  2016-10-31

<160>  6     

<170>  PatentIn version 3.5

<210>  1
<211>  760
<212>  PRT
<213>  Homo sapiens

<400>  1

Met Met Asp Gln Ala Arg Ser Ala Phe Ser Asn Leu Phe Gly Gly Glu 
1               5                   10                  15      


Pro Leu Ser Tyr Thr Arg Phe Ser Leu Ala Arg Gln Val Asp Gly Asp 
            20                  25                  30          


Asn Ser His Val Glu Met Lys Leu Ala Val Asp Glu Glu Glu Asn Ala 
        35                  40                  45              


Asp Asn Asn Thr Lys Ala Asn Val Thr Lys Pro Lys Arg Cys Ser Gly 
    50                  55                  60                  


Ser Ile Cys Tyr Gly Thr Ile Ala Val Ile Val Phe Phe Leu Ile Gly 
65                  70                  75                  80  


Phe Met Ile Gly Tyr Leu Gly Tyr Cys Lys Gly Val Glu Pro Lys Thr 
                85                  90                  95      


Glu Cys Glu Arg Leu Ala Gly Thr Glu Ser Pro Val Arg Glu Glu Pro 
            100                 105                 110         


Gly Glu Asp Phe Pro Ala Ala Arg Arg Leu Tyr Trp Asp Asp Leu Lys 
        115                 120                 125             


Arg Lys Leu Ser Glu Lys Leu Asp Ser Thr Asp Phe Thr Gly Thr Ile 
    130                 135                 140                 


Lys Leu Leu Asn Glu Asn Ser Tyr Val Pro Arg Glu Ala Gly Ser Gln 
145                 150                 155                 160 


Lys Asp Glu Asn Leu Ala Leu Tyr Val Glu Asn Gln Phe Arg Glu Phe 
                165                 170                 175     


Lys Leu Ser Lys Val Trp Arg Asp Gln His Phe Val Lys Ile Gln Val 
            180                 185                 190         


Lys Asp Ser Ala Gln Asn Ser Val Ile Ile Val Asp Lys Asn Gly Arg 
        195                 200                 205             


Leu Val Tyr Leu Val Glu Asn Pro Gly Gly Tyr Val Ala Tyr Ser Lys 
    210                 215                 220                 


Ala Ala Thr Val Thr Gly Lys Leu Val His Ala Asn Phe Gly Thr Lys 
225                 230                 235                 240 


Lys Asp Phe Glu Asp Leu Tyr Thr Pro Val Asn Gly Ser Ile Val Ile 
                245                 250                 255     


Val Arg Ala Gly Lys Ile Thr Phe Ala Glu Lys Val Ala Asn Ala Glu 
            260                 265                 270         


Ser Leu Asn Ala Ile Gly Val Leu Ile Tyr Met Asp Gln Thr Lys Phe 
        275                 280                 285             


Pro Ile Val Asn Ala Glu Leu Ser Phe Phe Gly His Ala His Leu Gly 
    290                 295                 300                 


Thr Gly Asp Pro Tyr Thr Pro Gly Phe Pro Ser Phe Asn His Thr Gln 
305                 310                 315                 320 


Phe Pro Pro Ser Arg Ser Ser Gly Leu Pro Asn Ile Pro Val Gln Thr 
                325                 330                 335     


Ile Ser Arg Ala Ala Ala Glu Lys Leu Phe Gly Asn Met Glu Gly Asp 
            340                 345                 350         


Cys Pro Ser Asp Trp Lys Thr Asp Ser Thr Cys Arg Met Val Thr Ser 
        355                 360                 365             


Glu Ser Lys Asn Val Lys Leu Thr Val Ser Asn Val Leu Lys Glu Ile 
    370                 375                 380                 


Lys Ile Leu Asn Ile Phe Gly Val Ile Lys Gly Phe Val Glu Pro Asp 
385                 390                 395                 400 


His Tyr Val Val Val Gly Ala Gln Arg Asp Ala Trp Gly Pro Gly Ala 
                405                 410                 415     


Ala Lys Ser Gly Val Gly Thr Ala Leu Leu Leu Lys Leu Ala Gln Met 
            420                 425                 430         


Phe Ser Asp Met Val Leu Lys Asp Gly Phe Gln Pro Ser Arg Ser Ile 
        435                 440                 445             


Ile Phe Ala Ser Trp Ser Ala Gly Asp Phe Gly Ser Val Gly Ala Thr 
    450                 455                 460                 


Glu Trp Leu Glu Gly Tyr Leu Ser Ser Leu His Leu Lys Ala Phe Thr 
465                 470                 475                 480 


Tyr Ile Asn Leu Asp Lys Ala Val Leu Gly Thr Ser Asn Phe Lys Val 
                485                 490                 495     


Ser Ala Ser Pro Leu Leu Tyr Thr Leu Ile Glu Lys Thr Met Gln Asn 
            500                 505                 510         


Val Lys His Pro Val Thr Gly Gln Phe Leu Tyr Gln Asp Ser Asn Trp 
        515                 520                 525             


Ala Ser Lys Val Glu Lys Leu Thr Leu Asp Asn Ala Ala Phe Pro Phe 
    530                 535                 540                 


Leu Ala Tyr Ser Gly Ile Pro Ala Val Ser Phe Cys Phe Cys Glu Asp 
545                 550                 555                 560 


Thr Asp Tyr Pro Tyr Leu Gly Thr Thr Met Asp Thr Tyr Lys Glu Leu 
                565                 570                 575     


Ile Glu Arg Ile Pro Glu Leu Asn Lys Val Ala Arg Ala Ala Ala Glu 
            580                 585                 590         


Val Ala Gly Gln Phe Val Ile Lys Leu Thr His Asp Val Glu Leu Asn 
        595                 600                 605             


Leu Asp Tyr Glu Arg Tyr Asn Ser Gln Leu Leu Ser Phe Val Arg Asp 
    610                 615                 620                 


Leu Asn Gln Tyr Arg Ala Asp Ile Lys Glu Met Gly Leu Ser Leu Gln 
625                 630                 635                 640 


Trp Leu Tyr Ser Ala Arg Gly Asp Phe Phe Arg Ala Thr Ser Arg Leu 
                645                 650                 655     


Thr Thr Asp Phe Gly Asn Ala Glu Lys Thr Asp Arg Phe Val Met Lys 
            660                 665                 670         


Lys Leu Asn Asp Arg Val Met Arg Val Glu Tyr His Phe Leu Ser Pro 
        675                 680                 685             


Tyr Val Ser Pro Lys Glu Ser Pro Phe Arg His Val Phe Trp Gly Ser 
    690                 695                 700                 


Gly Ser His Thr Leu Pro Ala Leu Leu Glu Asn Leu Lys Leu Arg Lys 
705                 710                 715                 720 


Gln Asn Asn Gly Ala Phe Asn Glu Thr Leu Phe Arg Asn Gln Leu Ala 
                725                 730                 735     


Leu Ala Thr Trp Thr Ile Gln Gly Ala Ala Asn Ala Leu Ser Gly Asp 
            740                 745                 750         


Val Trp Asp Ile Asp Asn Glu Phe 
        755                 760 


<210>  2
<211>  5093
<212>  DNA
<213>  Homo sapiens

<400>  2
acgcacagcc cccctggggg ccgggggcgg ggccaggcta taaaccgccg gttaggggcc       60

gccatcccct cagagcgtcg ggatatcggg tggcggctcg ggacggagga cgcgctagtg      120

ttcttctgtg tggcagttca gaatgatgga tcaagctaga tcagcattct ctaacttgtt      180

tggtggagaa ccattgtcat atacccggtt cagcctggct cggcaagtag atggcgataa      240

cagtcatgtg gagatgaaac ttgctgtaga tgaagaagaa aatgctgaca ataacacaaa      300

ggccaatgtc acaaaaccaa aaaggtgtag tggaagtatc tgctatggga ctattgctgt      360

gatcgtcttt ttcttgattg gatttatgat tggctacttg ggctattgta aaggggtaga      420

accaaaaact gagtgtgaga gactggcagg aaccgagtct ccagtgaggg aggagccagg      480

agaggacttc cctgcagcac gtcgcttata ttgggatgac ctgaagagaa agttgtcgga      540

gaaactggac agcacagact tcaccggcac catcaagctg ctgaatgaaa attcatatgt      600

ccctcgtgag gctggatctc aaaaagatga aaatcttgcg ttgtatgttg aaaatcaatt      660

tcgtgaattt aaactcagca aagtctggcg tgatcaacat tttgttaaga ttcaggtcaa      720

agacagcgct caaaactcgg tgatcatagt tgataagaac ggtagacttg tttacctggt      780

ggagaatcct gggggttatg tggcgtatag taaggctgca acagttactg gtaaactggt      840

ccatgctaat tttggtacta aaaaagattt tgaggattta tacactcctg tgaatggatc      900

tatagtgatt gtcagagcag ggaaaatcac ctttgcagaa aaggttgcaa atgctgaaag      960

cttaaatgca attggtgtgt tgatatacat ggaccagact aaatttccca ttgttaacgc     1020

agaactttca ttctttggac atgctcatct ggggacaggt gacccttaca cacctggatt     1080

cccttccttc aatcacactc agtttccacc atctcggtca tcaggattgc ctaatatacc     1140

tgtccagaca atctccagag ctgctgcaga aaagctgttt gggaatatgg aaggagactg     1200

tccctctgac tggaaaacag actctacatg taggatggta acctcagaaa gcaagaatgt     1260

gaagctcact gtgagcaatg tgctgaaaga gataaaaatt cttaacatct ttggagttat     1320

taaaggcttt gtagaaccag atcactatgt tgtagttggg gcccagagag atgcatgggg     1380

ccctggagct gcaaaatccg gtgtaggcac agctctccta ttgaaacttg cccagatgtt     1440

ctcagatatg gtcttaaaag atgggtttca gcccagcaga agcattatct ttgccagttg     1500

gagtgctgga gactttggat cggttggtgc cactgaatgg ctagagggat acctttcgtc     1560

cctgcattta aaggctttca cttatattaa tctggataaa gcggttcttg gtaccagcaa     1620

cttcaaggtt tctgccagcc cactgttgta tacgcttatt gagaaaacaa tgcaaaatgt     1680

gaagcatccg gttactgggc aatttctata tcaggacagc aactgggcca gcaaagttga     1740

gaaactcact ttagacaatg ctgctttccc tttccttgca tattctggaa tcccagcagt     1800

ttctttctgt ttttgcgagg acacagatta tccttatttg ggtaccacca tggacaccta     1860

taaggaactg attgagagga ttcctgagtt gaacaaagtg gcacgagcag ctgcagaggt     1920

cgctggtcag ttcgtgatta aactaaccca tgatgttgaa ttgaacctgg actatgagag     1980

gtacaacagc caactgcttt catttgtgag ggatctgaac caatacagag cagacataaa     2040

ggaaatgggc ctgagtttac agtggctgta ttctgctcgt ggagacttct tccgtgctac     2100

ttccagacta acaacagatt tcgggaatgc tgagaaaaca gacagatttg tcatgaagaa     2160

actcaatgat cgtgtcatga gagtggagta tcacttcctc tctccctacg tatctccaaa     2220

agagtctcct ttccgacatg tcttctgggg ctccggctct cacacgctgc cagctttact     2280

ggagaacttg aaactgcgta aacaaaataa cggtgctttt aatgaaacgc tgttcagaaa     2340

ccagttggct ctagctactt ggactattca gggagctgca aatgccctct ctggtgacgt     2400

ttgggacatt gacaatgagt tttaaatgtg atacccatag cttccatgag aacagcaggg     2460

tagtctggtt tctagacttg tgctgatcgt gctaaatttt cagtagggct acaaaacctg     2520

atgttaaaat tccatcccat catcttggta ctactagatg tctttaggca gcagctttta     2580

atacagggta gataacctgt acttcaagtt aaagtgaata accacttaaa aaatgtccat     2640

gatggaatat tcccctatct ctagaatttt aagtgctttg taatgggaac tgcctctttc     2700

ctgttgttgt taatgaaaat gtcagaaacc agttatgtga atgatctctc tgaatcctaa     2760

gggctggtct ctgctgaagg ttgtaagtgg tcgcttactt tgagtgatcc tccaacttca     2820

tttgatgcta aataggagat accaggttga aagaccttct ccaaatgaga tctaagcctt     2880

tccataagga atgtagctgg tttcctcatt cctgaaagaa acagttaact ttcagaagag     2940

atgggcttgt tttcttgcca atgaggtctg aaatggaggt ccttctgctg gataaaatga     3000

ggttcaactg ttgattgcag gaataaggcc ttaatatgtt aacctcagtg tcatttatga     3060

aaagagggga ccagaagcca aagacttagt atattttctt ttcctctgtc ccttccccca     3120

taagcctcca tttagttctt tgttattttt gtttcttcca aagcacattg aaagagaacc     3180

agtttcaggt gtttagttgc agactcagtt tgtcagactt taaagaataa tatgctgcca     3240

aattttggcc aaagtgttaa tcttagggga gagctttctg tccttttggc actgagatat     3300

ttattgttta tttatcagtg acagagttca ctataaatgg tgttttttta atagaatata     3360

attatcggaa gcagtgcctt ccataattat gacagttata ctgtcggttt tttttaaata     3420

aaagcagcat ctgctaataa aacccaacag atactggaag ttttgcattt atggtcaaca     3480

cttaagggtt ttagaaaaca gccgtcagcc aaatgtaatt gaataaagtt gaagctaaga     3540

tttagagatg aattaaattt aattaggggt tgctaagaag cgagcactga ccagataaga     3600

atgctggttt tcctaaatgc agtgaattgt gaccaagtta taaatcaatg tcacttaaag     3660

gctgtggtag tactcctgca aaattttata gctcagttta tccaaggtgt aactctaatt     3720

cccattttgc aaaatttcca gtacctttgt cacaatccta acacattatc gggagcagtg     3780

tcttccataa tgtataaaga acaaggtagt ttttacctac cacagtgtct gtatcggaga     3840

cagtgatctc catatgttac actaagggtg taagtaatta tcgggaacag tgtttcccat     3900

aattttcttc atgcaatgac atcttcaaag cttgaagatc gttagtatct aacatgtatc     3960

ccaactccta taattcccta tcttttagtt ttagttgcag aaacattttg tggtcattaa     4020

gcattgggtg ggtaaattca accactgtaa aatgaaatta ctacaaaatt tgaaatttag     4080

cttgggtttt tgttaccttt atggtttctc caggtcctct acttaatgag atagtagcat     4140

acatttataa tgtttgctat tgacaagtca ttttaacttt atcacattat ttgcatgtta     4200

cctcctataa acttagtgcg gacaagtttt aatccagaat tgaccttttg acttaaagca     4260

gagggacttt gtatagaagg tttgggggct gtggggaagg agagtcccct gaaggtctga     4320

cacgtctgcc tacccattcg tggtgatcaa ttaaatgtag gtatgaataa gttcgaagct     4380

ccgtgagtga accatcatta taaacgtgat gatcagctgt ttgtcatagg gcagttggaa     4440

acggcctcct agggaaaagt tcatagggtc tcttcaggtt cttagtgtca cttacctaga     4500

tttacagcct cacttgaatg tgtcactact cacagtctct ttaatcttca gttttatctt     4560

taatctcctc ttttatcttg gactgacatt tagcgtagct aagtgaaaag gtcatagctg     4620

agattcctgg ttcgggtgtt acgcacacgt acttaaatga aagcatgtgg catgttcatc     4680

gtataacaca atatgaatac agggcatgca ttttgcagca gtgagtctct tcagaaaacc     4740

cttttctaca gttagggttg agttacttcc tatcaagcca gtacgtgcta acaggctcaa     4800

tattcctgaa tgaaatatca gactagtgac aagctcctgg tcttgagatg tcttctcgtt     4860

aaggagatgg gccttttgga ggtaaaggat aaaatgaatg agttctgtca tgattcacta     4920

ttctagaact tgcatgacct ttactgtgtt agctctttga atgttcttga aattttagac     4980

tttctttgta aacaaatgat atgtccttat cattgtataa aagctgttat gtgcaacagt     5040

gtggagattc cttgtctgat ttaataaaat acttaaacac tgaaaaaaaa aaa            5093


<210>  3
<211>  418
<212>  PRT
<213>  Homo sapiens

<400>  3

Met Glu Ser Leu Thr Asp Pro Ser Lys Leu Asp Ser Gly Lys Glu Pro 
1               5                   10                  15      


His Ile Ser Leu Ile Pro Asn Lys Gln Asp Arg Thr Leu Thr Ile Val 
            20                  25                  30          


Asp Thr Gly Ile Gly Met Thr Lys Ala Asp Leu Ile Asn Asn Leu Gly 
        35                  40                  45              


Thr Ile Thr Lys Ser Glu Thr Lys Val Phe Met Glu Val Leu Gln Ala 
    50                  55                  60                  


Gly Ala Asp Ile Ser Met Ile Gly Gln Phe Ser Val Gly Phe Tyr Ser 
65                  70                  75                  80  


Ala Tyr Ser Val Ala Glu Lys Val Thr Val Ile Thr Lys His Asn Asn 
                85                  90                  95      


Asp Glu Gln Tyr Ala Trp Glu Ser Ser Leu Arg Gly Ser Phe Thr Glu 
            100                 105                 110         


Tyr Arg Glu Phe Tyr Lys Ser Leu Thr Ile Asn Trp Glu Asp Tyr Leu 
        115                 120                 125             


Ala Val Lys His Phe Ser Val Glu Gly Gln Leu Glu Phe Arg Ala Phe 
    130                 135                 140                 


Leu Phe Val Pro Arg Leu Ala Pro Phe Glu Leu Leu Glu Thr Arg Lys 
145                 150                 155                 160 


Lys Lys Asn Lys Ile Lys Leu Ser Ala Arg Arg Asp Leu Ile Met Asp 
                165                 170                 175     


Asn Cys Glu Glu Leu Ile Pro Glu Tyr Leu Asn Phe Ile Arg Gly Val 
            180                 185                 190         


Val Asp Ser Glu Asp Leu Pro Leu Asn Ile Phe Arg Glu Thr Lys Asp 
        195                 200                 205             


Gln Val Ala Asn Ser Thr Ile Val Gln Arg Leu Trp Lys His Gly Leu 
    210                 215                 220                 


Glu Val Ile Tyr Thr Ile Glu Pro Ile Asp Glu Tyr Cys Val Gln Gln 
225                 230                 235                 240 


Leu Lys Glu Phe Glu Gly Lys Thr Leu Val Ser Val Thr Lys Glu Asp 
                245                 250                 255     


Leu Glu Leu Pro Glu Asp Glu Glu Glu Lys Lys Lys Gln Glu Glu Gly 
            260                 265                 270         


Lys Gln Lys Thr Lys Gln Lys Lys Asn Gln Ser Leu Arg Thr Ser Ala 
        275                 280                 285             


Lys Ser Thr Tyr Gly Trp Thr Ala Asn Met Glu Arg Ile Met Lys Ala 
    290                 295                 300                 


Gln Ala Leu Arg Asp Asn Ser Thr Thr Gly Tyr Met Ala Ala Lys Lys 
305                 310                 315                 320 


His Leu Glu Ile Asn Pro Asp His Ser Phe Ile Asp Thr Leu Arg Gln 
                325                 330                 335     


Lys Ala Glu Thr Asp Lys Asn Asp Lys Ser Val Lys Asp Leu Val Ile 
            340                 345                 350         


Leu Leu Tyr Glu Thr Ala Leu Leu Ser Ser Asp Phe Gly Leu Glu Gly 
        355                 360                 365             


Pro Gln Thr His Ala Asn Arg Ile Tyr Arg Met Asn Lys Leu Gly Leu 
    370                 375                 380                 


Gly Thr Asp Glu Asp Asp Pro Thr Ala Asp Asp Thr Ser Ala Ala Val 
385                 390                 395                 400 


Thr Glu Glu Met Pro Pro Leu Glu Gly Asp Asp Asp Thr Ser Arg Met 
                405                 410                 415     


Glu Lys 
        


<210>  4
<211>  8210
<212>  DNA
<213>  Homo sapiens

<400>  4
gagctccggc tgccctgcac tggttcccag agactccctc cttcccaggt ccaaatggct       60

gcaggagcga agtgggcgga aaaaaagcga accagcttga gaaagggctt gacgtgcctg      120

cgtagggagg gcgcatgtcc ccgtgctccg tgtacgtggc ggccgcaggg gctagagggg      180

ggtccccccc gcaggtactc cactctcagt ctgcaaaagt gtacgcccgc agagccgccc      240

caggtgcctg ggtgttgtgt gattgacgcg gggaaggagg ggtcagccga tccctcccca      300

accctccatc ccatccctga ggattgggct ggtacccgcg tctctcggac aggtcagagc      360

gggtcgccgg gtggggtcgc tgcaaaaacc ctgccccggc cgcagccgag aggcggacgt      420

cgcggggagg gggcgggacc gccgagacag gcctggaaac tgctggaaat gccgcagtgc      480

cgccgccgcc ccttccgccg catgtcggca aagagtcccc gccagccccg gccggcgccc      540

tccccctacg ctgagctgcc cctcagcgcg aaccctccgc ccttcctcta ctcctgcgag      600

agtcgggatc tggggctacc caaggttggg tcccgaatgc cagtccctct gtcgggacgc      660

gagatgtgta gggcagatgc taggaagaag attgggtctg ggacgggtgg tccgcgtggt      720

tagctgcctc cgctcttttt cggtgtcccc cccagtcccg cccttgggtg tggggacgcc      780

tgccccacaa gtgtttaggg aggtcagtgg gttcctcgcc cgtagagaca ccgtttatgc      840

caaatgagca ctcctcatcc ccgctcttga tggagtcatg tcctagacgt gaaactatgg      900

ggctgtgatc acaagcaaat gtgtgggcgg atccgttgct tgggttcttc cccgccccct      960

ctttttttcg gaccatgacg tcaaggtggg ctggtggcgg caggtgcggg gttgacaatc     1020

atactccttt aaggcggagg gatctacagg agggcggctg tactgtgctt cgccttatat     1080

agggcgactt ggggcacgca gtagctctct cgagtcactc cggcgcagtg ttgggactgt     1140

ctgggtatcg gaaagcaagc ctacgttgct cactattacg tataatcctt ttcttttcaa     1200

ggtaaggctg agatctccgc taggcttctt tccctttagt gctgtattcg tgttgttttt     1260

gtttttttct gtcctttagg gagccttagt ctagatgtcg gggtggcttg tggataacgc     1320

tctggatttt tatagggtga gggtagtggt gggtgaggtt ttttgagtcc tcctcggttt     1380

tctctagtgt gtttgggggg tggggctttc tctcggcgcc tgctggccgt agcgaggtgg     1440

gctgtggggt tggggcagtg ggcggctggc agctgcacgt ggtggccgcg cggcccggga     1500

cgctgccatt tttgcccctc cacttccgga cgcggctacg gggcgtcgga gggggaccgc     1560

aggtggcggg ggtgcccgct cgggtgactc agcacggcct tgtgggactg gctttgtcac     1620

ctctcttatc ggacgcgttg ttaaagcctt cttgggtgct ttgtttctgt gagggagggt     1680

tgacggtgtg ggaagagagc tttcggtctc cagcacccga tactccctcc ttccagatct     1740

ttcttgcagt cccggtggag gaggggcggg gaggggagca ggttctggaa gattcatggg     1800

ctccttcctc cgcccttcct cgagagctga gattgttctg gaagcttctg gattctggcg     1860

ccccgcccca gtgcccggat gctgggggcg agggagggtg cactgcggcg ccccctcctc     1920

gcgtggtcct ggccgacgca tgtccggcag tgacgagtgt cggcctggtg gctacggcca     1980

ccatctttct tgggtttggt cctgttctgt aattttgtgc tgtgaaaggg tcgtggtgga     2040

gcttttggct taagaattct ttgtccggat ttaattgctc ctccggtggg tatcgtatgg     2100

atcccaggtt attcctccct gccctatggg caggagtgtc ccgcccttgg actggtctta     2160

ggaactgaca cctcaggggg agcagtttaa agttagtgcc atttttatct taaactagtc     2220

actttgacct cccccaaata aagaactgta ggtagtgatt ttcacattta aatttgtgta     2280

aggattactt gggatctcta gatacctggg ttggaccaac attatgattt ttctgccata     2340

ctaccagatg atgctgaggc tgctggtcac cattctttaa gtaggtgggt tctgtgacat     2400

ttggttgaag aatatttagc ttattttctt tttccttctg aattttcagg cctcccactt     2460

agtgtgtagt ctgagatctt taagagaatg catttttagt cttgggaagg gatagtactc     2520

cggttaaacc agtctgaact cactgtctaa ggtcctaaca aatgatatga cctttaggat     2580

ttttaaacat ggggccttag tgttcttttg taattaatga gatttttatt ttagatgcct     2640

gaggaagtgc accatggaga ggaggaggtg gagacttttg cctttcaggc agaaattgcc     2700

caactcatgt ccctcatcat caataccttc tattccaaca aggagatttt ccttcgggag     2760

ttgatctcta atgcttctga tgtaggtgct ctggtttcca catttggcat ggtttttttt     2820

tttgatactc tagaaggagg ggaaaggagt ggtttggcct ttgttgggga ctactattga     2880

agggggtaaa cttgcagcta ttccaaaaag atgggtttta ctctggccat cttgaacttg     2940

gaagggacta tgtccagaat aagtgggctc atggaactaa ctggttctaa agcctcaaga     3000

tagggggcaa tcagatttga ggctgagaga ggtaaaccaa gattttcttt gaagatacgg     3060

gctttaagaa agcaaaagtg gctgagcgtg ttggctcaca cctgtaatgc caaggcagga     3120

ggatcacttg agcctaggat ttcgagggca gcctgggcaa ccgcgagacc ttgtctctgc     3180

aaaaaattaa atattagttg ggcacggtgg catgtgctgt agtcccagct acttgggaag     3240

ctggggttgg gaggatggct cgaacctggg aggtcaaggc tgcagtgagc tgtcatcctt     3300

gccactgcac tgtagcttgg gcaacagagc aagagtctgt cttggaaaga gcaaaagtaa     3360

gttgctgttt gtatttccag gccttggaca agattcgcta tgagagcctg acagaccctt     3420

cgaagttgga cagtggtaaa gagctgaaaa ttgacatcat ccccaaccct caggaacgta     3480

ccctgacttt ggtagacaca ggcattggca tgaccaaagc tgatctcata aataatttgg     3540

gaaccattgc caagtctggt actaaagcat tcatggaggc tcttcaggta ttgcagttct     3600

gtaggcattc atacttatct gtgttctttg gttttttgct tctttaaaac ttgtgattga     3660

ctttaaactt gttggcaggc tggtgcagac atctccatga ttgggcagtt tggtgttggc     3720

ttttattctg cctacttggt ggcagagaaa gtggttgtga tcacaaagca caacgatgat     3780

gaacagtatg cttgggagtc ttctgctgga ggttccttca ctgtgcgtgc tgaccatggt     3840

aagttagctt ttctgttaca aggtagttgg gttaggattt tctgggctca caccagtagc     3900

agaaattttg ggcatcctgt ctgtaaagca gttcttcaca gcagttctgc tgatacttac     3960

taattgctgg tctcaactgc atatactttt taccctgtta cacgcttgta attgactctt     4020

ctaggtgagc ccattggcag gggtaccaaa gtgatcctcc atcttaaaga agatcagaca     4080

gagtacctag aagagaggcg ggtcaaagaa gtagtgaaga agcattctca gttcataggc     4140

tatcccatca ccctttatgt gagtatggac ttttaaatct tttacactta acgtgcagga     4200

tgtttcctgt tctggagaat ctcattgtcc ctggcttttg ctttccctgg tagtgttttg     4260

tactccaagg ctaacttctg tttttgttac ttagttggag aaggaacgag agaaggaaat     4320

tagtgatgat gaggcagagg aagagaaagg tgagaaagaa gaggaagata aagatgatga     4380

agaaaaaccc aagatcgaag atgtgggttc agatgaggag gatgacagcg gtaaggataa     4440

gaagaagaaa actaagaaga tcaaagagaa atacattgat caggaagaac taaacaagac     4500

caagcctatt tggaccagaa accctgatga catcacccaa gaggagtatg gagaattcta     4560

caagagcctc actaatgact gggaagacca cttggcagtc aaggtgtgag aagcctttgc     4620

atgttggctc aacatgcaca tatggagagg aatgagttag gtggaagagt gttgggtaat     4680

agacacacgg aacttgtcca actgataaca gaaatgtgat agccatgtga tttcacttac     4740

tgattaccct gtcatagtga agtgccatca tttctaatga cctcactttc tcttcttatg     4800

gaaatctggg taatgtctat tggcagcctt acacatccag ggttctgatc agaggggact     4860

gttttctaca tacagctagt acccatctag atcgtggagg gcattaaggc tcagttttct     4920

caggagctgc ttgttgtgtg tgctctatcc cttaggctta gggaggatca ttgttccact     4980

tttagataat ttggtgttgg ggctaaaagg tcctcttttg aaatgtacca cttatttttg     5040

gtttctttca gcacttttct gtagaaggtc agttggaatt cagggcattg ctatttattc     5100

ctcgtcgggc tccctttgac ctttttgaga acaagaagaa aaagaacaac atcaaactct     5160

atgtccgccg tgtgttcatc atggacagct gtgatgagtt gataccagag tatctcagtg     5220

agtatctcct tggcctaatt tagttgggtg aagtcttggg aggttttagg cattctgcta     5280

ggatattcta aggtaacagt tttctgcaat acatagtagg tgtaagggtt caggaggcta     5340

ttagagcctt ctgtttgaat ctggggacca ggtctggtct agctgttttt actgagcttt     5400

ctcaccctgg ttgatggcag attttatccg tggtgtggtt gactctgagg atctgcccct     5460

gaacatctcc cgagaaatgc tccagcagag caaaatcttg aaagtcattc gcaaaaacat     5520

tgttaagaag tgccttgagc tcttctctga gctggcagaa gacaaggaga attacaagaa     5580

attctatgag gcattctcta aaaatctcaa ggtaaaaagg caaataatgc ttattccctt     5640

taccactttc ttagtaataa caataaatta ttccattcac attgaaagtg aagttattgt     5700

agttaagctg gattgttttt cctcttccca cccttcaagc ttggaatcca cgaagactcc     5760

actaaccgcc gccgcctgtc tgagctgctg cgctatcata cctcccagtc tggagatgag     5820

atgacatctc tgtcagagta tgtttctcgc atgaaggaga cacagaagtc catctattac     5880

atcactggtg cgttgactct gattgaagcc tttttggagg agtggggagc acaattaggg     5940

cttcctggga actggcagta tgaggcattt tagtcactga gttcatttaa ttaccctaca     6000

ggtgagagca aagagcaggt ggccaactca gcttttgtgg agcgagtgcg gaaacggggc     6060

ttcgaggtgg tatatatgac cgagcccatt gacgagtact gtgtgcagca gctcaaggaa     6120

tttgatggga agagcctggt ctcagttacc aaggagggtc tggagctgcc tgaggatgag     6180

gaggagaaga agaagatgga agagagcaag gcaaagtttg agaacctctg caagctcatg     6240

aaagaaatct tagataagaa ggttgagaag gtaagccatt ctggggctag gatatatttt     6300

gtaacatctt cgaggtgggc tccctcacaa gcatgtttct atacaattag tggtttgagg     6360

cagcctattt actgtttcat gccttcttgc ctcttgttct cttctctagt caggtttaag     6420

gctattttaa taaaatttgg cacagattag gcattgcttc agttaacttc tgagagtaga     6480

taaaatacca tcattttctt ttttttttct ttttttgaga tggggtctcg ctctgtcacc     6540

caggctggag tgcagtggca cgatctctgc tcattgcaag ctccgcctcc tgggttcacg     6600

ccattctcct gccttagcct cctgagtagc tgccactaca ggcgcccgcc accacacccc     6660

ggctaatttt ttgtattttt agtagagatg gggtttcatc gcgttagcca ggatggtctc     6720

catctcctga ccttgtgatt cgcccacctc ggcctcccaa agtgctggga ttaacaggcg     6780

caagccacca tgcctggccg attttttttt tttttggact ggatctcgct cactgcaaac     6840

tcaagtctcc tgagtggctg ggattacaga tgtgtgctac cacacccggt taattttttg     6900

tagacagggt tttgccatgt tggccagcat ggtctcaaac tcaagtggtc tgtccacctc     6960

ctccccctgc tggaattagg cttgacaatg cctgttttct ctttcaaagt ggtaatgtca     7020

atctaaggct tttgtgatcg tccacaggtg acaatctcca atagacttgt gtcttcacct     7080

tgctgcattg tgaccagcac ctacggctgg acagccaata tggagcggat catgaaagcc     7140

caggcacttc gggacaactc caccatgggc tatatgatgg ccaaaaagca cctggagatc     7200

aaccctgacc accccattgt ggagacgctg cggcagaagg ctgaggccga caagaatgat     7260

aaggcagtta aggacctggt ggtgctgctg tttgaaaccg ccctgctatc ttctggcttt     7320

tcccttgagg atccccagac ccactccaac cgcatctatc gcatgatcaa gctaggtcta     7380

ggtaagtagc tttggtactt ggtgtggcaa ggagtttgtg caactcgtct cctctatgga     7440

tttgacttaa tgctatttgg tcaagtctca catggcttaa ttttacttca ggtattgatg     7500

aagatgaagt ggcagcagag gaacccaatg ctgcagttcc tgatgagatc ccccctctcg     7560

agggcgatga ggatgcgtct cgcatggaag aagtcgatta ggttaggagt tcatagttgg     7620

aaaacttgtg cccttgtata gtgtccccat gggctcccac tgcagcctcg agtgcccctg     7680

tcccacctgg ctccccctgc tggtgtctag tgtttttttc cctctcctgt ccttgtgttg     7740

aaggcagtaa actaagggtg tcaagcccca ttccctctct actcttgaca gcaggattgg     7800

atgttgtgta ttgtggttta ttttattttc ttcattttgt tctgaaatta aagtatgcaa     7860

aataaagaat atgccgtttt tatacagttc tgctttccct tgtgaagtgg atgttatcct     7920

tccctagctt cttcatccct ccagctcttg ctgttttcat gagcacagca agttgagctg     7980

gttttgtagt gaaaataaca gaataccagt gagtcttaag agttcacaca ctgaagctaa     8040

aggcagtttg gaaaaactac catataataa tgccctttca gtcaaccaaa acacaggacc     8100

aagtccactg cagtaattta atttaataaa ataaaattat aagagcaaaa agttacattt     8160

ctaaagtacc aaaacctgca acaggctcat ggaacagagc ctagggatcc                8210


<210>  5
<211>  290
<212>  PRT
<213>  Homo sapiens

<400>  5

Met Val Ile Gln Lys Glu Lys Lys Ser Cys Gly Gln Val Val Glu Glu 
1               5                   10                  15      


Trp Lys Glu Phe Val Trp Asn Pro Arg Thr His Gln Phe Met Gly Arg 
            20                  25                  30          


Thr Gly Thr Ser Trp Ala Phe Ile Leu Leu Phe Tyr Leu Val Phe Tyr 
        35                  40                  45              


Gly Phe Pro Thr Ala Met Phe Thr Leu Thr Met Trp Val Met Leu Gln 
    50                  55                  60                  


Thr Val Ser Asp His Thr Pro Lys Tyr Gln Asp Arg Leu Ala Thr Pro 
65                  70                  75                  80  


Gly Leu Met Ile Arg Pro Lys Thr Glu Asn Leu Asp Val Ile Val Asn 
                85                  90                  95      


Val Ser Asp Thr Glu Ser Trp Asp Gln His Val Gln Lys Leu Asn Lys 
            100                 105                 110         


Phe Leu Glu Pro Tyr Asn Asp Ser Met Gln Ala Gln Lys Asn Asp Val 
        115                 120                 125             


Cys Arg Pro Gly Arg Tyr Tyr Glu Gln Pro Asp Asn Gly Val Leu Asn 
    130                 135                 140                 


Tyr Pro Lys Leu Ala Cys Gln Phe Asn Arg Thr Gln Leu Gly Asn Cys 
145                 150                 155                 160 


Ser Gly Ile Gly Asp Ser Thr His Tyr Gly Tyr Ser Thr Gly Gln Pro 
                165                 170                 175     


Cys Val Phe Ile Lys Met Asn Arg Val Ile Asn Phe Tyr Ala Gly Ala 
            180                 185                 190         


Asn Gln Ser Met Asn Val Thr Cys Ala Gly Lys Arg Asp Glu Asp Ala 
        195                 200                 205             


Glu Asn Leu Gly Asn Phe Val Met Phe Pro Ala Asn Gly Asn Ile Asp 
    210                 215                 220                 


Leu Met Tyr Phe Pro Tyr Tyr Gly Lys Lys Phe His Val Asn Tyr Thr 
225                 230                 235                 240 


Gln Pro Leu Val Ala Val Lys Phe Leu Asn Val Thr Pro Asn Val Glu 
                245                 250                 255     


Val Asn Val Glu Cys Arg Ile Asn Ala Ala Asn Ile Ala Thr Asp Asp 
            260                 265                 270         


Glu Arg Asp Lys Phe Ala Gly Arg Val Ala Phe Lys Leu Arg Ile Asn 
        275                 280                 285             


Lys Thr 
    290 


<210>  6
<211>  2208
<212>  DNA
<213>  Homo sapiens

<400>  6
gaattcatgc taaattgctg gaaggctgcg tctctgctgt ggtgtcagtt ccggatgcct       60

catcgccagg ggcgcgccgc agccacccac cctccggacc gcggcagctg ctgacccgcc      120

atcgccatgg cccgcgggaa agccaaggag gagggcagct ggaagaaatt catctggaac      180

tcagagaaga aggagtttct gggcaggacc ggtggcagtt ggtttaagat ccttctattc      240

tacgtaatat tttatggctg cctggctggc atcttcatcg gaaccatcca agtgatgctg      300

ctcaccatca gtgaatttaa gcccacatat caggaccgag tggccccgcc aggattaaca      360

cagattcctc agatccagaa gactgaaatt tcctttcgtc ctaatgatcc caagagctat      420

gaggcatatg tactgaacat agttaggttc ctggaaaagt acaaagattc agcccagagg      480

gatgacatga tttttgaaga ttgtggcgat gtgcccagtg aaccgaaaga acgaggagac      540

tttaatcatg aacgaggaga gcgaaaggtc tgcagattca agcttgaatg gctgggaaat      600

tgctctggat taaatgatga aacttatggc tacaaagagg gcaaaccgtg cattattata      660

aagctcaacc gagttctagg cttcaaacct aagcctccca agaatgagtc cttggagact      720

tacccagtga tgaagtataa cccaaatgtc cttcccgttc agtgcactgg caagcgagat      780

gaagataagg ataaagttgg aaatgtggag tattttggac tgggcaactc ccctggtttt      840

cctctgcagt attatccgta ctatggcaaa ctcctgcagc ccaaatacct gcagcccctg      900

ctggccgtac agttcaccaa tcttaccatg gacactgaaa ttcgcataga gtgtaaggcg      960

tacggtgaga acattgggta cagtgagaaa gaccgttttc agggacgttt tgatgtaaaa     1020

attgaagtta agagctgatc acaagcacaa atctttccca ctagccattt aataagttaa     1080

aaaaagatac aaaaacaaaa acctactagt cttgaacaaa ctgtcatacg tatgggacct     1140

acacttaatc tatatgcttt acactagctt tctgcattta ataggttaga atgtaaatta     1200

aagtgtagca atagcaacaa aatatttatt ctactgtaaa tgacaaaaga aaaagaaaaa     1260

ttgagccttg ggacgtgccc atttttactg taaattatga ttccgtaact gaccttgtag     1320

taagcagtgt ttctggcccc taagtattgc tgccttgtgt attttattta gtgtacagta     1380

ctacaggtgc atactctggt catttttcaa gccatgtttt attgtatctg ttttctactt     1440

tatgtgagca aggtttgctg tccaaggtgt aaatattcaa cgggaataaa actggcatgg     1500

taattttttt tttttgtttg ttttttgttt tttggctctt tcaaaggtaa tggcccatcg     1560

atgagcattt ttaacatact ccatagtctt ttcctgtggt gttaggtctt tatttttatt     1620

tttttcctgg gggctggggt gggggtttgt catgggggaa ctgcccttta aattttaagt     1680

gacactacag aaaaacacaa aaaggtgatg ggttgtgtta tgcttgtatt gaatgctgtc     1740

ttgacatctc ttgccttgtc ctccggtatg ttctaaagct gtgtctgaga tctggatctg     1800

cccatcactt tggcctaggg acagggctaa ttaatttgct ttatacattt tcttttactt     1860

tccttttttc ctttctggag gcatcacatg ctggtgctgt gtctttatga atgttttaac     1920

cattttcatg gtggaagaat tttatattta tgcagttgta caattttatt tttttctgca     1980

agaaaaagtg taatgtatga aataaaccaa agtcacttgt ttgaaaataa atctttattt     2040

tgaactttat aaaagcaatg cagtacccca tagactggtg ttaaatgttg tctacagtgc     2100

aaaatccatg ttctaacata tgtaataatt gccaggagta cagtgctctt gttgatcttg     2160

tattcagtca ggttaaaaca acggacaata aaagaatgaa ccgaattc                  2208


