                         SEQUENCE LISTING

<110>  WARP DRIVE BIO, INC.
 
<120>  COMPOSITIONS AND METHODS FOR THE PRODUCTION OF COMPOUNDS

<130>  50869-016WO2

<140>  PCT/US17/58800
<141>  2017-10-27

<150>  US 62/414,410
<151>  2016-10-28

<160>  204   

<170>  PatentIn version 3.5

<210>  1
<211>  920
<212>  PRT
<213>  Streptomyces malaysiensis

<400>  1

Gln Pro Leu Ala Ile Val Gly Met Ala Cys Arg Leu Pro Gly Gly Val 
1               5                   10                  15      


Ser Ser Pro Glu Asp Leu Trp Arg Leu Val Glu Ser Gly Thr Asp Ala 
            20                  25                  30          


Ile Ser Gly Phe Pro Val Asp Arg Gly Trp Asp Val Asp Gly Leu Tyr 
        35                  40                  45              


Asp Pro Asp Pro Asp Val Pro Gly Lys Ser Tyr Thr Val Glu Gly Gly 
    50                  55                  60                  


Phe Leu Asp Ala Val Thr Gly Phe Asp Ala Pro Phe Phe Gly Ile Ser 
65                  70                  75                  80  


Pro Arg Glu Ala Leu Ala Met Asp Pro Gln Gln Arg Leu Val Leu Glu 
                85                  90                  95      


Ala Ser Trp Glu Ala Phe Glu Arg Ala Gly Ile Glu Pro Gly Ser Val 
            100                 105                 110         


Arg Gly Ser Asp Thr Gly Val Phe Met Gly Ala Phe Pro Gly Gly Tyr 
        115                 120                 125             


Gly Thr Gly Ala Asp Leu Gly Gly Phe Gly Met Thr Gly Gly Ala Ala 
    130                 135                 140                 


Ser Val Leu Ser Gly Arg Val Ser Tyr Phe Phe Gly Leu Glu Gly Pro 
145                 150                 155                 160 


Ala Met Thr Val Asp Thr Val Cys Ser Ser Ser Leu Val Ala Leu His 
                165                 170                 175     


Gln Ala Gly Tyr Ala Leu Arg His Gly Glu Cys Ser Leu Ala Leu Val 
            180                 185                 190         


Gly Gly Val Thr Val Met Ser Thr Pro Gln Thr Phe Val Glu Phe Ser 
        195                 200                 205             


Arg Gln Arg Gly Leu Ala Ala Asp Gly Arg Cys Lys Ala Phe Ser Asp 
    210                 215                 220                 


Asp Ala Asp Gly Thr Gly Trp Ser Glu Gly Val Gly Val Leu Leu Val 
225                 230                 235                 240 


Glu Arg Leu Ser Asp Ala Gln Ala Arg Gly His Asn Ile Leu Ala Val 
                245                 250                 255     


Val Arg Gly Ser Ala Val Asn Gln Asp Gly Ala Ser Asn Gly Leu Thr 
            260                 265                 270         


Ala Pro Asn Gly Pro Ser Gln Gln Arg Val Ile Arg Gln Ala Leu Ala 
        275                 280                 285             


Asn Ala Gly Leu Thr Gly Ala Asp Val Asp Val Val Glu Ala His Gly 
    290                 295                 300                 


Thr Gly Thr Thr Leu Gly Asp Pro Ile Glu Ala Gln Ala Val Ile Ala 
305                 310                 315                 320 


Thr Tyr Gly Gln Asp Arg Asp Gln Pro Val Leu Leu Gly Ser Leu Lys 
                325                 330                 335     


Ser Asn Leu Gly His Thr Gln Ala Ala Ala Gly Val Ser Gly Val Ile 
            340                 345                 350         


Lys Met Val Met Ala Leu Gln Asn Gly Val Val Pro Arg Thr Leu His 
        355                 360                 365             


Val Glu Glu Pro Ser Arg His Val Asp Trp Thr Ala Gly Ala Val Glu 
    370                 375                 380                 


Leu Val Thr Glu Asn Gln Pro Trp Pro Glu Leu Gly Arg Ala Arg Arg 
385                 390                 395                 400 


Ala Ala Val Ser Ser Phe Gly Leu Ser Gly Thr Asn Ala His Val Ile 
                405                 410                 415     


Leu Glu Ser Ala Pro Asp Gln Pro Pro Ala Pro Ser Thr Asp Ser Pro 
            420                 425                 430         


Val Ser Ala Val Thr Ala Gly Val Val Pro Leu Pro Ile Ser Ala Lys 
        435                 440                 445             


Thr Leu Pro Ala Leu Ala Asp Leu Glu Asp Arg Leu Arg Thr Tyr Leu 
    450                 455                 460                 


Thr Thr Thr Pro Asp Thr Asp Leu Pro Ala Val Ala Ser Thr Leu Ala 
465                 470                 475                 480 


Thr Thr Arg Ser Leu Phe Glu His Arg Ala Val Leu Leu Gly Glu Asp 
                485                 490                 495     


Thr Val Thr Gly Thr Ala Ile Pro Asp Pro Arg Val Val Phe Val Phe 
            500                 505                 510         


Pro Gly Gln Gly Trp Gln Trp Gln Gly Met Gly Ser Ala Leu Leu Thr 
        515                 520                 525             


Ser Ser Thr Val Phe Ala Glu Arg Met Ala Glu Cys Ala Ala Ala Leu 
    530                 535                 540                 


Ser Glu Phe Val Asp Trp Asp Leu Leu Thr Val Leu Asp Asp Pro Ser 
545                 550                 555                 560 


Val Val Asp Arg Val Asp Val Val Gln Pro Ala Cys Trp Ala Val Met 
                565                 570                 575     


Ile Ser Leu Ala Ala Val Trp Gln Ala Ala Gly Ile His Pro Asp Ile 
            580                 585                 590         


Val Leu Gly His Ser Gln Gly Glu Ile Ala Ala Ala Cys Leu Ala Gly 
        595                 600                 605             


Ala Ile Ser Leu Pro Asp Ala Ala Arg Ile Val Ala Gln Arg Ser Gln 
    610                 615                 620                 


Leu Ile Ala His Gln Leu Gly His Gly Ala Met Ala Ser Ile Ser Leu 
625                 630                 635                 640 


Pro Ala Asp Asp Ile Pro Thr Thr Asp Gln Val Trp Ile Ala Ala His 
                645                 650                 655     


Asn Gly Thr Ser Thr Val Ile Ala Gly Asp Pro Gln Ala Val Glu Ala 
            660                 665                 670         


Val Leu Ala Thr Cys Glu Thr Arg Gly Ala Arg Val Arg Lys Ile Asn 
        675                 680                 685             


Val Asp Tyr Ala Ser His Thr Pro His Val Glu Gln Ile Arg Thr Glu 
    690                 695                 700                 


Leu Leu Asp Ile Thr Thr Gly Ile Glu Ala His Thr Pro Ala Val Pro 
705                 710                 715                 720 


Trp Leu Ser Thr Thr Asp Asn Thr Trp Ile Asp Gln Pro Leu Asp Pro 
                725                 730                 735     


Thr Tyr Trp Tyr Arg Asn Leu Arg Glu Pro Val Arg Phe Gly Pro Ala 
            740                 745                 750         


Ile Asp Leu Leu Gln Thr Gln Asp Asn Asn Leu Phe Ile Glu Ile Ser 
        755                 760                 765             


Ala Ser Pro Val Leu Leu Gln Thr Met Asp Asn Ala Ala Thr Val Ala 
    770                 775                 780                 


Thr Leu Arg Arg Asp Glu Asp Thr Thr His Arg Leu Leu Thr Ala Phe 
785                 790                 795                 800 


Ala Glu Ala His Val His Gly Ala Thr Ile Asn Trp Pro Thr Val Leu 
                805                 810                 815     


Asp Thr Thr Thr Thr Pro Val Asp Leu Pro Thr Tyr Pro Phe Gln Arg 
            820                 825                 830         


Gln Arg Tyr Trp Ala Thr Ser Asn Gly His Pro Ala Asp Leu Thr Pro 
        835                 840                 845             


Glu Ala Leu Leu Lys Val Val Arg Asp Ser Ala Ala Met Val Leu Gly 
    850                 855                 860                 


His Ala Ser Ala Asp Thr Val Pro Thr Ala Thr Ala Phe Gln Glu Leu 
865                 870                 875                 880 


Gly Leu Asp Ser Leu Thr Ala Val Glu Leu Arg Asn Ser Leu Thr Lys 
                885                 890                 895     


Ala Thr Gly Leu Arg Leu Pro Ala Thr Met Ala Phe Asp Tyr Pro Thr 
            900                 905                 910         


Pro Asp Ala Leu Ala Ala Arg Leu 
        915                 920 


<210>  2
<211>  943
<212>  PRT
<213>  Streptomyces malaysiensis

<400>  2

Glu Pro Leu Ala Ile Val Gly Met Ala Cys Arg Leu Pro Gly Gly Val 
1               5                   10                  15      


Ser Ser Pro Glu Asp Leu Trp Arg Leu Val Glu Ser Gly Thr Asp Ala 
            20                  25                  30          


Ile Thr Asp Phe Pro Thr Asp Arg Gly Trp Asp Thr Asp Thr Leu Phe 
        35                  40                  45              


Asp Pro Asp Pro Asp Thr Pro Gly Lys Thr Tyr Thr Val His Gly Gly 
    50                  55                  60                  


Phe Leu Asp Asp Val Ala Gly Phe Asp Ala Pro Phe Phe Gly Ile Ser 
65                  70                  75                  80  


Pro Arg Glu Ala Val Ala Met Asp Pro Gln Gln Arg Leu Val Leu Glu 
                85                  90                  95      


Ser Ser Trp Glu Ala Phe Glu Arg Ala Gly Ile Gln Pro Asp Ser Ile 
            100                 105                 110         


Arg Gly Ser Asp Thr Gly Val Phe Met Gly Ala Tyr Pro Asp Gly Tyr 
        115                 120                 125             


Gly Ile Gly Ala Asp Leu Ala Gly Phe Gly Val Thr Ala Gly Ala Gly 
    130                 135                 140                 


Ser Val Leu Ser Gly Arg Val Ser Tyr Phe Phe Gly Leu Glu Gly Pro 
145                 150                 155                 160 


Ala Met Thr Val Asp Thr Ala Cys Ser Ser Ser Leu Val Ala Leu His 
                165                 170                 175     


Gln Ala Ala Tyr Ala Leu Arg Gln Gly Glu Cys Ser Leu Ala Leu Val 
            180                 185                 190         


Gly Gly Val Thr Val Met Pro Ser Pro Arg Thr Phe Ile Glu Phe Ser 
        195                 200                 205             


Arg Gln Arg Gly Leu Ala Ala Asp Gly Arg Ser Lys Ala Phe Ala Asp 
    210                 215                 220                 


Ala Ala Asp Gly Thr Gly Phe Ser Glu Gly Val Gly Val Leu Leu Val 
225                 230                 235                 240 


Glu Arg Leu Ser Asp Ala Gln Ala Lys Gly His Asn Ile Leu Ala Leu 
                245                 250                 255     


Val Arg Ser Ser Ala Val Asn Gln Asp Gly Ala Ser Asn Gly Leu Thr 
            260                 265                 270         


Ala Pro Asn Gly Pro Ser Gln Gln Arg Val Ile Gln Ser Ala Leu Ala 
        275                 280                 285             


Gly Ala Gly Leu Thr Ser Ala Asp Val Asp Val Val Glu Ala His Gly 
    290                 295                 300                 


Thr Gly Thr Thr Leu Gly Asp Pro Ile Glu Ala Gln Ala Val Leu Ala 
305                 310                 315                 320 


Thr Tyr Gly Gln Asp Arg Asp Arg Pro Val Leu Leu Gly Ser Leu Lys 
                325                 330                 335     


Ser Asn Leu Gly His Thr Gln Ala Ala Ala Gly Val Ser Gly Val Ile 
            340                 345                 350         


Lys Met Val Met Ala Leu Gln His Asn Thr Val Pro Ala Thr Leu His 
        355                 360                 365             


Val Asp Ala Pro Ser Arg His Val Asp Trp Thr Ala Gly Ala Val Arg 
    370                 375                 380                 


Leu Ala Thr Glu Asn Gln Pro Trp Pro Glu Thr Asn Arg Pro Arg Arg 
385                 390                 395                 400 


Ala Gly Val Ser Ser Phe Gly Val Ser Gly Thr Asn Ala His Val Ile 
                405                 410                 415     


Leu Glu Gln Ala Pro Ala Ala Ser Pro Val Glu Pro Val Asp Thr Thr 
            420                 425                 430         


Asp Val Val Val Pro Leu Val Val Ser Ala Arg Ser Ser Gly Ser Leu 
        435                 440                 445             


Ser Asp Gln Ala Asp Arg Leu Ala Ala Leu Val Gly Ser Pro Asp Ala 
    450                 455                 460                 


Pro Ala Leu Thr Ser Leu Ala Asp Ala Leu Leu Thr Arg Arg Thr Val 
465                 470                 475                 480 


Phe Ser Gln Arg Ala Val Val Val Ala Gly Ser His Glu Gln Ala Ala 
                485                 490                 495     


Ala Gly Leu Arg Ala Leu Ala Ala Gly Asp Ser His Pro Ala Leu Val 
            500                 505                 510         


Thr Gly Ala Ala Gly Pro Ala Arg Val Val Leu Val Phe Pro Gly Gln 
        515                 520                 525             


Gly Ser Gln Trp Ala Gly Met Gly Ala Glu Leu Leu Asp Ala Ser Pro 
    530                 535                 540                 


Val Phe Ala Ala Arg Ile Ala Glu Cys Ala Glu Ala Leu Arg Pro Trp 
545                 550                 555                 560 


Val Asp Trp Ser Leu Asp Glu Val Leu Arg Gly Asp Ala Ser Ala Asp 
                565                 570                 575     


Val Leu Gly Arg Val Asp Val Val Gln Pro Ala Ser Phe Ala Val Met 
            580                 585                 590         


Val Gly Leu Ala Ala Val Trp Glu Ser Ala Gly Val Arg Pro Asp Ala 
        595                 600                 605             


Val Leu Gly His Ser Gln Gly Glu Ile Ala Ala Ala Tyr Val Ala Gly 
    610                 615                 620                 


Ala Leu Ser Leu Thr Asp Ala Ala Lys Ile Val Ala Val Arg Ser Arg 
625                 630                 635                 640 


Leu Ile Ala Ala Arg Leu Gly Arg Gly Gly Met Ala Ser Val Ala Leu 
                645                 650                 655     


Ala Pro Glu Glu Ala Ala Lys Leu Gly Arg Thr Glu Leu Ala Ala Val 
            660                 665                 670         


Asn Ser Pro Ala Ser Val Val Ile Ala Gly Asp Ala Glu Ala Leu Asp 
        675                 680                 685             


Glu Thr Leu Ala Met Leu Glu Gly Glu Gly Val Arg Val Arg Arg Val 
    690                 695                 700                 


Ala Val Asp Tyr Ala Ser His Thr Pro His Val Glu Glu Leu Glu Gln 
705                 710                 715                 720 


Ser Met Ala Glu Ala Leu Ala Asp Val Arg Ser Arg Gln Pro Arg Val 
                725                 730                 735     


Arg Phe Leu Ser Thr Val Thr Gly Asp Trp Val Thr Glu Ala Gly Ala 
            740                 745                 750         


Leu Asp Gly Gly Tyr Trp Tyr Arg Asn Leu Arg Gln Pro Val Arg Phe 
        755                 760                 765             


Gly Pro Ala Val Ala Ser Leu Ala Glu Ala Gly Tyr Thr Val Phe Val 
    770                 775                 780                 


Glu Ala Ser Ala His Pro Val Leu Val Gln Pro Val Ala Glu Thr Leu 
785                 790                 795                 800 


Asp Arg Thr Asp Ala Val Val Thr Gly Thr Leu Arg Arg Gln Asp Gly 
                805                 810                 815     


Gly Leu Pro Arg Leu Leu Thr Ser Met Ala Glu Leu Phe Val Gly Gly 
            820                 825                 830         


Val Pro Val Asn Trp Pro Val Leu Leu Pro Ala Gly Ala Val Arg Gly 
        835                 840                 845             


Trp Val Asp Leu Pro Thr Tyr Ala Phe Asp His Gln Arg Tyr Trp Leu 
    850                 855                 860                 


Glu Asn Arg Glu Leu Thr Pro Glu Ala Leu Leu Lys Leu Val Cys Gly 
865                 870                 875                 880 


Arg Ala Ala Ala Val Leu Gly His Val Asp Ala Asp Ala Val Pro Val 
                885                 890                 895     


Ala Ala Ala Phe Arg Asp Leu Gly Val Asp Ser Leu Thr Ala Val Glu 
            900                 905                 910         


Leu Arg Asn Ser Leu Ala Lys Ala Thr Gly Leu Arg Leu Pro Ala Thr 
        915                 920                 925             


Leu Val Phe Asp Tyr Pro Thr Pro Thr Val Leu Ala Gly Arg Leu 
    930                 935                 940             


<210>  3
<211>  891
<212>  PRT
<213>  Streptomyces malaysiensis

<400>  3

Glu Pro Leu Ala Ile Val Gly Met Ala Cys Arg Leu Pro Gly Gly Val 
1               5                   10                  15      


Leu Ser Pro Glu Asp Leu Trp Arg Leu Val Glu Ser Gly Gly Asp Ala 
            20                  25                  30          


Ile Ser Gly Phe Pro Val Asp Arg Gly Trp Asp Val Glu Asn Leu Phe 
        35                  40                  45              


Asp Pro Asp Pro Asp Ala Ala Gly Arg Thr Tyr Ala Val Arg Gly Gly 
    50                  55                  60                  


Phe Leu Asp Gly Ala Ala Gly Phe Asp Ala Ser Phe Phe Gly Ile Ser 
65                  70                  75                  80  


Pro Arg Glu Ala Gln Ala Met Asp Pro Gln Gln Arg Leu Val Leu Glu 
                85                  90                  95      


Val Ser Trp Glu Ala Phe Glu Arg Ala Gly Ile Glu Pro Gly Ser Val 
            100                 105                 110         


Arg Gly Ser Asp Thr Gly Val Phe Met Gly Ala Tyr Pro Gly Gly Tyr 
        115                 120                 125             


Gly Met Gly Thr Asp Leu Gly Gly Phe Gly Met Thr Ser Val Ala Val 
    130                 135                 140                 


Ser Val Leu Ala Gly Arg Val Ser Tyr Phe Phe Gly Leu Glu Gly Pro 
145                 150                 155                 160 


Ala Met Thr Val Asp Thr Ala Cys Ser Ser Ser Leu Val Ala Leu His 
                165                 170                 175     


Gln Ala Gly Ser Ala Leu Arg Gln Gly Glu Cys Ser Leu Ala Leu Val 
            180                 185                 190         


Gly Gly Val Thr Val Met Pro Thr Pro Gln Thr Phe Val Glu Phe Ser 
        195                 200                 205             


Arg Gln Arg Gly Leu Ala Ala Asp Gly Arg Cys Lys Ala Phe Ala Asp 
    210                 215                 220                 


Ala Ala Asp Gly Thr Gly Phe Ser Glu Gly Val Gly Val Leu Leu Val 
225                 230                 235                 240 


Glu Arg Leu Ser Asp Ala Gln Ala Arg Gly His Asn Ile Leu Ala Val 
                245                 250                 255     


Val Arg Gly Ser Ala Val Asn Gln Asp Gly Ala Ser Asn Gly Leu Thr 
            260                 265                 270         


Ala Pro Asn Gly Pro Ser Gln Gln Arg Val Ile Gln Ser Ala Leu Ala 
        275                 280                 285             


Gly Ala Gly Leu Thr Ser Ala Asp Val Asp Val Val Glu Ala His Gly 
    290                 295                 300                 


Thr Gly Thr Thr Leu Gly Asp Pro Ile Glu Ala Gln Ala Val Ile Ala 
305                 310                 315                 320 


Thr Tyr Gly Gln Asp Arg Asp Gln Pro Val Leu Leu Gly Ser Leu Lys 
                325                 330                 335     


Ser Asn Leu Gly His Thr Gln Ala Ala Ala Gly Val Ser Gly Val Ile 
            340                 345                 350         


Lys Met Val Met Ala Leu Gln Asn Gly Val Val Pro Arg Thr Leu His 
        355                 360                 365             


Ile Asp Glu Pro Ser Arg His Ile Asp Trp Thr Ala Gly Ala Val Glu 
    370                 375                 380                 


Leu Val Thr Glu Asn Gln Ser Trp Pro Glu Thr Gly Arg Asp Arg Arg 
385                 390                 395                 400 


Ala Ala Val Ser Ser Phe Gly Ile Ser Gly Thr Asn Ala His Val Ile 
                405                 410                 415     


Leu Glu Ser Ala Pro Ala Gln Pro Val Pro Pro Val Asp Thr Pro Val 
            420                 425                 430         


Ser Asp Val Thr Ala Gly Val Val Pro Leu Pro Ile Ser Ala Arg Thr 
        435                 440                 445             


Val Pro Ala Leu Ala Asp Leu Glu Asp Arg Leu Arg Ala Tyr Leu Thr 
    450                 455                 460                 


Thr Thr Pro Glu Thr Asp Leu Pro Ala Val Ala Ser Thr Leu Ala Met 
465                 470                 475                 480 


Thr Arg Ser Val Phe Glu His Arg Ala Val Leu Leu Gly Glu Glu Thr 
                485                 490                 495     


Val Thr Gly Ile Ala Val Ser Asp Pro Arg Val Val Phe Val Phe Ser 
            500                 505                 510         


Gly Gln Gly Ser Gln Arg Val Gly Met Gly Glu Glu Leu Ala Ala Ala 
        515                 520                 525             


Phe Pro Leu Phe Ala Arg Leu His Arg Gln Val Trp Asp Leu Leu Asp 
    530                 535                 540                 


Val Pro Asp Leu Glu Val Asp Asp Thr Gly Tyr Val Gln Pro Ala Leu 
545                 550                 555                 560 


Phe Ala Leu Gln Val Ala Leu Phe Gly Leu Leu Glu Ser Trp Gly Val 
                565                 570                 575     


Arg Pro Gln Ala Val Leu Gly His Ser Val Gly Glu Val Ala Ala Gly 
            580                 585                 590         


Tyr Val Ala Gly Val Trp Ser Leu Glu Asp Ala Cys Thr Leu Val Ser 
        595                 600                 605             


Ala Arg Ala Arg Leu Met Gln Ala Leu Pro Ala Gly Gly Ala Met Val 
    610                 615                 620                 


Ala Val Pro Val Ser Glu Glu Gln Ala Arg Ala Val Leu Val Asp Gly 
625                 630                 635                 640 


Val Glu Ile Ala Ala Val Asn Gly Pro Ala Ser Val Val Leu Ser Gly 
                645                 650                 655     


Asp Glu Ser Ala Val Leu Arg Val Ala Glu Gly Leu Gly Arg Trp Thr 
            660                 665                 670         


Arg Leu Ser Ala Ser His Ala Phe His Ser Val Arg Met Glu Pro Met 
        675                 680                 685             


Leu Glu Glu Phe Arg Gln Val Ala Ser Glu Leu Thr Tyr Arg Glu Pro 
    690                 695                 700                 


Arg Ile Val Met Ala Ala Gly Glu Gln Val Thr Thr Pro Glu Tyr Trp 
705                 710                 715                 720 


Val Arg Gln Val Arg Asp Thr Val Arg Phe Gly Asp Gln Val Ala Ala 
                725                 730                 735     


Phe Gly Asp Ala Val Phe Leu Glu Ile Gly Pro Asp Arg Thr Leu Ser 
            740                 745                 750         


Arg Leu Ile Asp Gly Ile Ala Met Leu Asp Gly Asp Asp Glu Val Arg 
        755                 760                 765             


Ala Ala Val Ala Ala Leu Ala Val Met His Val Gln Gly Val Gly Val 
    770                 775                 780                 


Asp Trp Pro Ala Ile Leu Gly Thr Thr Thr Gly Arg Val Leu Asp Leu 
785                 790                 795                 800 


Pro Thr Tyr Ala Phe Gln His Glu Arg Tyr Trp Met Val Ile Gln Glu 
                805                 810                 815     


Leu Ser Pro Glu Ala Leu Leu Lys Ile Val Arg Asp Ser Ala Ala Met 
            820                 825                 830         


Val Leu Gly His Ala Asn Ala Asp Thr Val Pro Thr Ala Thr Ala Phe 
        835                 840                 845             


Gln Glu Leu Gly Leu Asp Ser Leu Thr Ala Val Glu Leu Arg Asn Ser 
    850                 855                 860                 


Leu Thr Lys Ala Thr Gly Leu Arg Leu Pro Ala Thr Met Ala Phe Asp 
865                 870                 875                 880 


Tyr Pro Thr Pro Ala Ala Leu Ala Gly Arg Leu 
                885                 890     


<210>  4
<211>  924
<212>  PRT
<213>  Streptomyces malaysiensis

<400>  4

Glu Pro Leu Ala Ile Val Gly Met Ala Cys Arg Leu Pro Gly Gly Val 
1               5                   10                  15      


Ser Thr Pro Glu Asp Leu Trp Arg Leu Val Glu Ser Gly Thr Asp Ala 
            20                  25                  30          


Ile Thr Asp Phe Pro Thr Asp Arg Gly Trp Asp Thr Asp Asp Leu Phe 
        35                  40                  45              


Asp Pro Asp Pro Asp Thr Pro Gly Lys Thr Tyr Thr Val His Gly Gly 
    50                  55                  60                  


Phe Leu Asp Asp Val Ala Gly Phe Asp Ala Ser Phe Phe Gly Ile Ser 
65                  70                  75                  80  


Pro Arg Glu Ala Leu Ala Met Asp Ser Gln Gln Arg Leu Val Leu Glu 
                85                  90                  95      


Ala Ser Trp Glu Ala Phe Glu Arg Ala Gly Ile Glu Pro Gly Ser Val 
            100                 105                 110         


Arg Gly Ser Asp Thr Gly Val Phe Met Gly Ala Tyr Pro Asp Gly Tyr 
        115                 120                 125             


Gly Ile Gly Val Asp Leu Gly Gly Phe Gly Ala Thr Ala Gly Ala Gly 
    130                 135                 140                 


Ser Val Leu Ser Gly Arg Leu Ser Tyr Phe Phe Gly Leu Glu Gly Pro 
145                 150                 155                 160 


Ala Met Thr Val Asp Thr Ala Cys Ser Ser Ser Leu Val Ala Leu His 
                165                 170                 175     


Gln Ala Gly Ser Ala Leu Arg Gln Gly Glu Cys Ser Leu Ala Leu Val 
            180                 185                 190         


Gly Gly Val Thr Val Ile Ala Asn Pro Gln Ile Phe Val Glu Phe Ser 
        195                 200                 205             


Arg Gln Arg Gly Leu Ala Ala Asp Gly Arg Cys Lys Ala Phe Ala Asp 
    210                 215                 220                 


Asn Ala Asp Gly Thr Gly Phe Ser Glu Gly Val Gly Val Leu Leu Val 
225                 230                 235                 240 


Glu Arg Leu Ser Asp Ala Gln Ala Arg Gly His Asn Ile Leu Ala Leu 
                245                 250                 255     


Val Arg Ser Ser Ala Val Asn Gln Asp Gly Ala Ser Asn Gly Leu Thr 
            260                 265                 270         


Ala Pro Asn Gly Pro Ser Gln Gln Arg Val Ile Arg Gln Ala Leu Ala 
        275                 280                 285             


Asn Ala Gly Leu Thr Gly Ala Glu Val Asp Val Val Glu Ala His Gly 
    290                 295                 300                 


Thr Gly Thr Thr Leu Gly Asp Pro Ile Glu Ala Gln Ala Val Leu Ala 
305                 310                 315                 320 


Thr Tyr Gly Gln Asp Arg Asp Gln Pro Val Leu Leu Gly Ser Leu Lys 
                325                 330                 335     


Ser Asn Leu Gly His Thr Gln Ala Ala Ala Gly Val Ser Gly Val Ile 
            340                 345                 350         


Lys Met Val Met Ala Leu Arg His Asp Thr Val Pro Ala Thr Leu His 
        355                 360                 365             


Ile Asp Glu Pro Ser Arg His Ile Asp Trp Thr Ala Gly Ala Val Glu 
    370                 375                 380                 


Leu Val Thr Glu Asn Gln Pro Trp Pro Val Leu Asp Arg Pro Arg Arg 
385                 390                 395                 400 


Ala Ala Val Ser Ala Phe Gly Val Ser Gly Thr Asn Ala His Val Ile 
                405                 410                 415     


Leu Glu Ser Ala Pro Asp Gln Pro Pro Ala Ser Ala Thr Asp Thr Pro 
            420                 425                 430         


Ala Pro Ala Val Thr Ala Gly Val Val Pro Leu Pro Ile Ser Ala Lys 
        435                 440                 445             


Thr Val Pro Ala Leu Ala Asp Leu Glu Asp Arg Leu Arg Ala Tyr Leu 
    450                 455                 460                 


Thr Thr Thr Pro Glu Thr Asp Leu Pro Ala Val Ala Ser Thr Leu Ala 
465                 470                 475                 480 


Thr Thr Arg Ser Leu Phe Glu His Arg Ala Val Leu Leu Gly Glu Asp 
                485                 490                 495     


Thr Val Thr Gly Thr Thr Ile Pro Asp Pro Arg Ile Val Phe Val Phe 
            500                 505                 510         


Pro Gly Gln Gly Trp Gln Trp Gln Gly Met Gly Ser Ala Leu Leu Thr 
        515                 520                 525             


Ser Ser Thr Val Phe Ala Glu Arg Met Ala Glu Cys Ala Ala Ala Leu 
    530                 535                 540                 


Ser Glu Phe Val Asp Trp Asp Leu Leu Thr Val Leu Asp Asp Pro Ser 
545                 550                 555                 560 


Ile Val Asp Arg Val Asp Val Val Gln Pro Ala Cys Trp Ala Val Met 
                565                 570                 575     


Ile Ser Leu Ala Ala Val Trp Gln Ala Ala Gly Ile His Pro Asp Ile 
            580                 585                 590         


Val Leu Gly His Ser Gln Gly Glu Ile Ala Ala Ala Cys Leu Ala Gly 
        595                 600                 605             


Ala Ile Ser Leu Pro Asp Ala Ala Arg Ile Val Ala Gln Arg Ser Gln 
    610                 615                 620                 


Leu Ile Ala His Gln Leu Gly His Gly Ala Met Ala Ser Ile Ser Leu 
625                 630                 635                 640 


Pro Ala Asp Asp Ile Pro Thr Thr Asp Lys Val Trp Ile Ala Ala His 
                645                 650                 655     


Asn Gly Thr Ser Thr Val Ile Ala Gly Asp Pro Gln Ala Val Glu Ala 
            660                 665                 670         


Ile Leu Ala Thr Cys Glu Thr Arg Gly Ala Arg Val Arg Lys Ile Asn 
        675                 680                 685             


Val Asp Tyr Ala Ser His Thr Pro His Val Glu Gln Ile Arg Thr Glu 
    690                 695                 700                 


Leu Leu Asp Ile Thr Thr Gly Ile Glu Ala His Thr Pro Thr Val Pro 
705                 710                 715                 720 


Trp Leu Ser Thr Thr Asp Asn Thr Trp Ile Asp Gln Pro Leu Asp Pro 
                725                 730                 735     


Thr Tyr Trp Tyr Arg Asn Leu Arg Glu Pro Val Arg Phe Gly Pro Ala 
            740                 745                 750         


Ile Asp Leu Leu Gln Thr Gln Asp Asn Asn Leu Phe Ile Glu Ile Ser 
        755                 760                 765             


Ala Ser Pro Val Leu Leu Gln Thr Met Asp Asn Ala Thr Thr Val Ala 
    770                 775                 780                 


Thr Leu Arg Arg Asp Glu Asp Thr Thr Gln Arg Leu Leu Thr Ala Phe 
785                 790                 795                 800 


Ala Glu Ala His Val His Gly Ala Thr Ile Asn Trp Pro Thr Val Leu 
                805                 810                 815     


Asn Thr Thr Thr Thr Pro Val Asp Leu Pro Thr Tyr Pro Phe Gln Arg 
            820                 825                 830         


Gln Arg Tyr Trp Ala Thr Ser Asn Asp Arg Leu Asn Gly Arg Thr Ser 
        835                 840                 845             


Val Glu Gln His Arg Ile Met Val Glu Leu Val Leu Ala His Ala Thr 
    850                 855                 860                 


Ser Val Leu Gly His Glu Ser Pro Asp Ala Ile Ala Pro Asp Arg Ala 
865                 870                 875                 880 


Phe Lys Asp Leu Gly Met Asp Ser Leu Thr Ala Ile Glu Leu Arg Asn 
                885                 890                 895     


His Leu Val Ala Glu Thr Gly Val Arg Leu Pro Ala Thr Thr Ala Phe 
            900                 905                 910         


Asp His Pro Thr Ala Asp Asp Leu Ala Lys Arg Leu 
        915                 920                 


<210>  5
<211>  951
<212>  PRT
<213>  Streptomyces malaysiensis

<400>  5

Glu Pro Ile Ala Ile Val Ser Met Ser Cys Arg Ala Pro Gly Gly Val 
1               5                   10                  15      


Asp Ser Pro Glu Ser Leu Trp Arg Leu Val Glu Ser Gly Thr Asp Ala 
            20                  25                  30          


Ile Thr Asp Phe Pro Gly Asp Arg Gly Trp Asp Val Ala Gly Leu Tyr 
        35                  40                  45              


Ser Pro Asp Pro Thr Gly Tyr Lys Thr Tyr Cys Val Gln Gly Gly Phe 
    50                  55                  60                  


Leu Asp Ala Ala Ala Asp Phe Asp Ala Ala Phe Phe Gly Ile Ser Pro 
65                  70                  75                  80  


Arg Glu Ala Leu Gly Met Asp Pro Gln Gln Arg Leu Leu Leu Glu Thr 
                85                  90                  95      


Ser Trp Glu Ala Ile Glu Arg Ala Arg Ile Asp Pro Arg Ser Leu Pro 
            100                 105                 110         


Gly Arg Asn Val Gly Val Tyr Val Gly Gly Ala Ala Gln Gly Tyr Gly 
        115                 120                 125             


Val Gly Ala Ile Asp Gln Gln Arg Asp Asn Val Ile Thr Gly Ser Ser 
    130                 135                 140                 


Ile Ser Leu Leu Ser Gly Arg Leu Ser Tyr Ala Leu Gly Leu Glu Gly 
145                 150                 155                 160 


Pro Gly Val Thr Val Asp Thr Ala Cys Ser Ser Ser Leu Val Ala Leu 
                165                 170                 175     


His Leu Ala Cys Gln Ala Leu Arg Gln Arg Glu Cys Ser Met Ala Leu 
            180                 185                 190         


Val Ser Gly Val Ser Val Ile Pro Thr Pro Asp Val Phe Val Glu Phe 
        195                 200                 205             


Ser Arg Gln Arg Gly Leu Ala Ala Asp Gly Arg Cys Lys Ser Phe Ser 
    210                 215                 220                 


Ala Ser Ala Asp Gly Thr Ile Trp Ala Glu Gly Val Gly Val Leu Val 
225                 230                 235                 240 


Leu Glu Arg Leu Ser Glu Ala Thr Arg Leu Gly His Arg Val Leu Ala 
                245                 250                 255     


Val Val Arg Gly Ser Ala Val Asn Ser Asp Gly Ala Ser Asn Gly Leu 
            260                 265                 270         


Thr Ala Pro Asn Gly Val Ser Gln Gln Arg Val Ile Arg Gln Ala Leu 
        275                 280                 285             


Thr Gly Ala Gly Leu Thr Ala Ala Asp Val Asp Val Val Glu Ala His 
    290                 295                 300                 


Gly Thr Gly Thr Lys Leu Gly Asp Pro Ile Glu Ala Glu Ala Ile Leu 
305                 310                 315                 320 


Ala Thr Tyr Gly Gln Asp Arg Ser Thr Pro Val Cys Leu Gly Ser Leu 
                325                 330                 335     


Lys Ser Asn Ile Gly His Ala Met Ala Ala Ser Gly Val Leu Ala Val 
            340                 345                 350         


Ile Lys Met Val Glu Ala Met Arg His Gly Leu Ile Pro Arg Thr Leu 
        355                 360                 365             


His Val Glu Glu Pro Ser Pro His Val Asp Trp Ala Ser Gly Asp Val 
    370                 375                 380                 


Ala Leu Leu Thr Glu Asn Gln Pro Trp Pro Asp Asp Ala Lys Leu Arg 
385                 390                 395                 400 


Arg Ala Gly Val Ser Ser Phe Gly Leu Ser Gly Thr Asn Ala His Val 
                405                 410                 415     


Val Leu Glu Gln Tyr Arg Ala Pro Ala Ala Pro Asp Ile Thr Thr Thr 
            420                 425                 430         


Glu His Gln Pro Leu Ala Trp Thr Leu Ser Ala Arg Asp Pro Lys Ala 
        435                 440                 445             


Leu Arg Glu Gln Ala Gly Arg Leu His Ala Ala Leu Thr Glu Ser Pro 
    450                 455                 460                 


Arg Trp Arg Pro Leu Asp Ile Gly Tyr Ser Leu Ala Thr Thr Arg Ser 
465                 470                 475                 480 


Asn Phe Ala His Arg Ala Val Ala Val Gly Ser Asp Arg Glu Leu Leu 
                485                 490                 495     


Arg Ala Leu Ser Lys Leu Ala Asp Gly Ser Ala Trp Pro Ala Leu Val 
            500                 505                 510         


Thr Ala Thr Ala Lys Asp Arg Arg Val Ala Tyr Leu Phe Asp Gly Gln 
        515                 520                 525             


Gly Ser Gln Arg Pro Asp Met Gly Ser Gly Leu Tyr Glu Arg Phe Pro 
    530                 535                 540                 


Ala Phe Ala Arg Ala Trp Asp Arg Ile Ser Ala Glu Phe Gly Lys His 
545                 550                 555                 560 


Leu Asp His Ser Leu Thr Asp Val Tyr Leu Gly Arg Gly Asp Ala Ala 
                565                 570                 575     


Thr Ala Asp Leu Val Asp Asp Thr Leu Tyr Ala Gln Ala Gly Leu Phe 
            580                 585                 590         


Thr Met Glu Ile Ala Leu Phe Glu Leu Leu Ala Glu Trp Gly Val Arg 
        595                 600                 605             


Pro Asp Phe Val Ser Gly His Ser Ile Gly Glu Thr Ala Ala Ala Tyr 
    610                 615                 620                 


Ala Ala Gly Val Leu Ser Leu Glu Asp Val Thr Lys Leu Ile Val Ala 
625                 630                 635                 640 


Arg Gly Arg Ala Leu Arg Gln Val Pro Pro Gly Ala Met Val Ala Leu 
                645                 650                 655     


Arg Ala Gly Glu Asp Glu Ala Arg Glu Phe Leu Gly Arg Thr Gly Ala 
            660                 665                 670         


Ala Leu Asp Leu Ala Ala Val Asn Ser Pro Thr Ser Val Val Val Ser 
        675                 680                 685             


Gly Ala Ser Glu Ala Val Ala Gly Phe Arg Ala Arg Trp Thr Glu Ser 
    690                 695                 700                 


Gly Arg Glu Ala Arg Thr Leu Asn Val Arg His Ala Phe His Ser Arg 
705                 710                 715                 720 


His Val Glu Ala Val Leu Gly Glu Phe Arg Glu Val Leu Glu Ser Leu 
                725                 730                 735     


Thr Phe Arg Thr Pro Ala Leu Pro Val Val Ser Thr Val Thr Gly Arg 
            740                 745                 750         


Leu Ile Glu Pro Thr Glu Leu Ser Thr Ser Glu Tyr Trp Leu Arg Gln 
        755                 760                 765             


Val Arg Gln Thr Val Arg Phe His Asp Ala Val Arg Glu Leu Ser Gly 
    770                 775                 780                 


Gln Gly Val Gly Thr Phe Val Glu Ile Gly Pro Ser Gly Ala Leu Ala 
785                 790                 795                 800 


Ser Ala Gly Leu Glu Cys Leu Gly Asp Glu Ala Ser Phe His Ala Val 
                805                 810                 815     


Gln Arg Pro Gly Ser Pro Gly Asp Val Cys Leu Met Thr Ala Val Ala 
            820                 825                 830         


Glu Leu His Ala Gly Gly Thr Thr Val Asp Trp Ala Thr Val Leu Ala 
        835                 840                 845             


Gly Gly Arg Ala Thr Asp Leu Pro Val Tyr Pro Phe Gln His Gly Ser 
    850                 855                 860                 


Tyr Trp Leu Ala Pro Ala Arg Pro Ser Ala Pro Glu Glu Pro Arg Thr 
865                 870                 875                 880 


Met Leu Glu Leu Val Arg Leu Glu Ala Ala Ile Ala Leu Ser Ile Thr 
                885                 890                 895     


Asp Pro Gly Leu Ile Ala Asp Asp Ser Ser Phe Leu Asp Leu Gly Phe 
            900                 905                 910         


Asp Ser Ile Ser Ala Leu Arg Leu Ser Asn Arg Leu Ala Ala Val Thr 
        915                 920                 925             


Gly Leu Asp Leu Pro Pro Ser Leu Leu Phe Asp His Pro Thr Pro Ala 
    930                 935                 940                 


Glu Leu Ala Ala Arg Leu Asp 
945                 950     


<210>  6
<211>  918
<212>  PRT
<213>  Streptomyces malaysiensis

<400>  6

Glu Pro Leu Ala Ile Val Gly Met Ala Cys Arg Leu Pro Gly Gly Val 
1               5                   10                  15      


Ser Ser Pro Asp Asp Leu Trp Arg Leu Val Ala Ser Gly Thr Asp Ala 
            20                  25                  30          


Ile Ser Glu Phe Pro Ala Asp Arg Gly Trp Asp Val Asp Asn Leu Tyr 
        35                  40                  45              


Asp Pro Asp Pro Asp Ala Pro Gly Lys Thr Tyr Thr Val Leu Gly Gly 
    50                  55                  60                  


Phe Leu Asp Gly Val Ala Gly Phe Asp Ala Ser Phe Phe Gly Ile Ser 
65                  70                  75                  80  


Pro Arg Glu Ala Leu Ala Met Asp Pro Gln Gln Arg Leu Met Leu Glu 
                85                  90                  95      


Val Ser Trp Glu Ala Phe Glu His Ala Gly Ile Pro Pro Arg Ser Val 
            100                 105                 110         


Arg Gly Ser Asp Thr Gly Val Phe Met Gly Ala Phe Pro Ser Gly Tyr 
        115                 120                 125             


Asn Ala Gly Leu Glu Glu Phe Gly Met Thr Gly Asp Ala Val Ser Val 
    130                 135                 140                 


Leu Ser Gly Arg Val Ser Tyr Phe Phe Gly Leu Glu Gly Pro Ala Ile 
145                 150                 155                 160 


Thr Val Asp Thr Ala Cys Ser Ser Ser Leu Val Ala Leu His Gln Ala 
                165                 170                 175     


Ser Ser Ala Leu Arg Gln Gly Glu Cys Ser Leu Ala Leu Val Gly Gly 
            180                 185                 190         


Val Thr Val Leu Ala Thr Pro Gln Thr Phe Val Glu Phe Ser Arg Gln 
        195                 200                 205             


Arg Gly Leu Ala Leu Asp Gly Arg Ser Lys Ala Phe Ala Asp Ala Ala 
    210                 215                 220                 


Asp Gly Ala Gly Trp Ala Glu Gly Val Gly Val Leu Val Val Glu Arg 
225                 230                 235                 240 


Leu Ser Asp Ala Arg Ala Lys Gly His Gln Ile Trp Gly Val Ile Arg 
                245                 250                 255     


Gly Ser Ala Val Asn Gln Asp Gly Ala Ser Asn Gly Leu Ser Ala Pro 
            260                 265                 270         


Asn Gly Pro Ser Gln Gln Arg Val Ile Arg Gln Ala Leu Ala Asn Ala 
        275                 280                 285             


Gly Leu Ala Pro His Glu Val Asp Val Val Glu Ala His Gly Thr Gly 
    290                 295                 300                 


Thr Met Leu Gly Asp Pro Ile Glu Ala Gln Ala Val Ile Ala Thr Tyr 
305                 310                 315                 320 


Gly Gln Asp Arg Glu Gln Pro Leu Leu Leu Gly Ser Leu Lys Ser Asn 
                325                 330                 335     


Val Gly His Thr Gln Ala Ala Ala Gly Val Ser Gly Val Ile Lys Met 
            340                 345                 350         


Val Met Ala Leu Gln His Asp Thr Val Pro Ala Thr Leu His Val Asp 
        355                 360                 365             


Ala Pro Ser Arg His Val Asp Trp Thr Ala Gly Ala Val Glu Leu Val 
    370                 375                 380                 


Thr Glu Asn Arg Pro Trp Pro Glu Thr Gly Arg Val Arg Arg Ala Gly 
385                 390                 395                 400 


Val Ser Ser Phe Gly Ile Ser Gly Thr Asn Ala His Val Ile Leu Glu 
                405                 410                 415     


Ser Ala Pro Glu Gln Pro Ala Ser Pro Pro Glu Ala Val Ala Pro Val 
            420                 425                 430         


Val Ala Ser Asp Arg Val Pro Leu Val Ile Ser Ala Lys Thr Pro Ala 
        435                 440                 445             


Ala Leu Ala Glu Met Glu Asn Arg Leu Arg Ala Tyr Leu Ala Ala Ala 
    450                 455                 460                 


Pro Gly Ala Asp Pro Arg Ala Val Ala Ser Thr Leu Ala Thr Ala Arg 
465                 470                 475                 480 


Ser Val Phe Glu His Arg Ala Val Leu Leu Gly Glu Asn Thr Ile Thr 
                485                 490                 495     


Gly Thr Val Ala Gly Ala Asp Pro Arg Val Val Phe Val Phe Pro Gly 
            500                 505                 510         


Gln Gly Trp Gln Gln Leu Gly Met Gly Arg Ala Leu Arg Glu Ser Ser 
        515                 520                 525             


Pro Val Phe Ala Ala Arg Met Ala Glu Cys Ala Ala Ala Leu Ser Glu 
    530                 535                 540                 


Phe Val Asp Trp Asp Leu Phe Thr Met Leu Asp Asp Pro Ala Val Ile 
545                 550                 555                 560 


Asp Arg Ile Asp Val Leu Gln Pro Ala Cys Trp Ala Val Met Met Ser 
                565                 570                 575     


Leu Ala Ala Val Trp Gln Ala Ala Gly Val Arg Pro Asp Ala Val Ile 
            580                 585                 590         


Gly His Ser Gln Gly Glu Ile Ala Ala Ala Cys Val Ala Gly Ala Leu 
        595                 600                 605             


Ser Leu Arg Asp Ala Ala Arg Ile Val Ala Leu Arg Ser Gln Leu Leu 
    610                 615                 620                 


Ala Arg Glu Met Gly His Gly Val Met Ala Ala Val Ala Leu Pro Ala 
625                 630                 635                 640 


Asp Asp Ile Pro Leu Val Asp Gly Val Trp Ile Gly Ala Arg Asn Gly 
                645                 650                 655     


Pro Ser Ser Thr Val Ile Ser Gly Thr Pro Glu Ala Val Glu Val Val 
            660                 665                 670         


Val Ala Ala Cys Glu Glu Arg Gly Ala Arg Val Arg Arg Ile Thr Ala 
        675                 680                 685             


Ala Val Ala Ser His Ser Pro Leu Gly Glu Lys Ile Arg Thr Glu Leu 
    690                 695                 700                 


Leu Gly Ile Ser Ala Ser Ile Pro Ser Arg Thr Pro Val Val Pro Trp 
705                 710                 715                 720 


Leu Ser Thr Ala Asp Gly Ile Trp Ile Glu Ala Pro Leu Asp Pro Ala 
                725                 730                 735     


Tyr Trp Trp Arg Asn Leu Arg Glu Pro Val Gly Phe Gly Pro Ala Val 
            740                 745                 750         


Asp Leu Leu Gln Ala Arg Gly Glu Asn Val Phe Leu Glu Met Ser Ala 
        755                 760                 765             


Ser Pro Val Leu Leu Pro Ala Met Asn Asp Ala Val Thr Val Ala Thr 
    770                 775                 780                 


Leu Arg Arg Asp Asp Asp Thr Pro Asp Arg Met Leu Thr Ala Leu Ala 
785                 790                 795                 800 


Glu Ala His Ala His Gly Val Ile Val Asp Trp Pro Arg Val Phe Gly 
                805                 810                 815     


Ser Thr Thr Arg Val Leu Asp Leu Pro Thr Tyr Ala Phe Glu His Gln 
            820                 825                 830         


Arg Tyr Trp Ala Val Asn Gly Arg Pro Ala Asp Leu Thr Pro Glu Ala 
        835                 840                 845             


Leu Leu Lys Leu Val Cys Gly Arg Ala Ala Ala Val Leu Gly His Val 
    850                 855                 860                 


Asp Ala Asp Ala Val Pro Val Ala Val Ala Phe Arg Asp Leu Gly Val 
865                 870                 875                 880 


Asp Ser Leu Thr Ala Val Glu Leu Arg Asn Ser Leu Ala Lys Ala Thr 
                885                 890                 895     


Gly Leu Arg Leu Pro Ala Thr Leu Val Phe Asp Tyr Pro Thr Pro Thr 
            900                 905                 910         


Val Leu Ala Gly Arg Leu 
        915             


<210>  7
<211>  890
<212>  PRT
<213>  Streptomyces malaysiensis


<220>
<221>  misc_feature
<222>  (102)..(102)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (128)..(128)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (130)..(130)
<223>  Xaa can be any naturally occurring amino acid

<400>  7

Glu Pro Leu Ala Ile Val Gly Met Ala Cys Arg Leu Pro Gly Gly Val 
1               5                   10                  15      


Leu Ser Pro Glu Asp Leu Trp Arg Leu Val Glu Ser Gly Gly Asp Ala 
            20                  25                  30          


Ile Ser Gly Phe Pro Val Asp Arg Gly Trp Asp Val Glu Asn Leu Phe 
        35                  40                  45              


Asp Pro Asp Pro Asp Ala Ala Gly Arg Thr Tyr Ala Val Arg Gly Gly 
    50                  55                  60                  


Phe Leu Asp Gly Ala Ala Gly Phe Asp Ala Ser Phe Phe Gly Ile Ser 
65                  70                  75                  80  


Pro Arg Glu Ala Gln Ala Met Asp Pro Gln Gln Arg Leu Val Leu Glu 
                85                  90                  95      


Val Ser Trp Glu Ala Xaa Glu Arg Ala Gly Ile Glu Pro Gly Ser Val 
            100                 105                 110         


Arg Gly Ser Asp Thr Gly Val Phe Met Gly Ala Tyr Pro Gly Gly Xaa 
        115                 120                 125             


Gly Xaa Gly Thr Asp Leu Gly Gly Phe Gly Met Thr Ser Val Ala Val 
    130                 135                 140                 


Ser Val Leu Ala Gly Arg Val Ser Tyr Phe Phe Gly Leu Glu Gly Pro 
145                 150                 155                 160 


Ala Met Thr Val Asp Thr Ala Cys Ser Ser Ser Leu Val Ala Leu His 
                165                 170                 175     


Gln Ala Gly Ser Ala Leu Arg Gln Gly Glu Cys Ser Leu Ala Leu Val 
            180                 185                 190         


Gly Gly Val Thr Val Met Pro Thr Pro Gln Thr Phe Val Glu Phe Ser 
        195                 200                 205             


Arg Gln Arg Gly Leu Ala Ala Asp Gly Arg Cys Lys Ala Phe Ala Asp 
    210                 215                 220                 


Ala Ala Asp Gly Thr Gly Phe Ser Glu Gly Val Gly Val Leu Leu Val 
225                 230                 235                 240 


Glu Arg Leu Ser Asp Ala Gln Ala Arg Gly His Asn Ile Leu Ala Val 
                245                 250                 255     


Val Arg Gly Ser Ala Val Asn Gln Asp Gly Ala Ser Asn Gly Leu Thr 
            260                 265                 270         


Ala Pro Asn Gly Pro Ser Gln Gln Arg Val Ile Arg Gln Ala Leu Ala 
        275                 280                 285             


Asn Ala Gly Leu Ala Gly Ala Glu Val Asp Val Val Glu Ala His Gly 
    290                 295                 300                 


Thr Gly Thr Thr Leu Gly Asp Pro Ile Glu Ala Gln Ala Val Ile Ala 
305                 310                 315                 320 


Thr Tyr Gly Gln Asp Arg Asp Gln Pro Val Leu Leu Gly Ser Leu Lys 
                325                 330                 335     


Ser Asn Leu Gly His Thr Gln Ala Ala Ala Gly Val Ser Gly Val Ile 
            340                 345                 350         


Lys Met Val Met Ala Leu Arg His Asp Thr Val Pro Ala Thr Leu His 
        355                 360                 365             


Ile Asp Glu Pro Ser Arg His Ile Asp Trp Thr Ala Gly Ala Val Glu 
    370                 375                 380                 


Leu Val Thr Glu Asn Gln Ser Trp Pro Glu Thr Gly Arg Asp Arg Arg 
385                 390                 395                 400 


Ala Ala Val Ser Ser Phe Gly Ile Ser Gly Thr Asn Ala His Val Ile 
                405                 410                 415     


Leu Glu Ser Ala Pro Ala Gln Pro Val Pro Pro Met Asp Thr Pro Val 
            420                 425                 430         


Ser Ala Val Thr Ala Gly Val Val Pro Leu Pro Ile Ser Ala Arg Thr 
        435                 440                 445             


Val Pro Ala Leu Ala Asp Leu Glu Asp Arg Leu Arg Ala Tyr Leu Thr 
    450                 455                 460                 


Ala Thr Pro Glu Thr Asp Leu Pro Ala Val Ala Ser Thr Leu Ala Val 
465                 470                 475                 480 


Thr Arg Ser Val Phe Glu His Arg Ala Val Leu Leu Gly Glu Glu Thr 
                485                 490                 495     


Val Thr Gly Ile Ala Val Ser Asp Pro Arg Val Val Phe Val Phe Ser 
            500                 505                 510         


Gly Gln Gly Ser Gln Arg Val Gly Met Gly Glu Glu Leu Ala Ala Ala 
        515                 520                 525             


Phe Pro Leu Phe Ala Arg Leu His Arg Gln Val Trp Asp Leu Leu Asp 
    530                 535                 540                 


Val Pro Asp Leu Glu Val Asp Asp Thr Gly Tyr Val Gln Pro Ala Leu 
545                 550                 555                 560 


Phe Ala Leu Gln Val Ala Leu Phe Gly Leu Leu Glu Ser Trp Gly Val 
                565                 570                 575     


Arg Pro Gln Ala Val Ile Gly His Ser Val Gly Glu Val Ala Ala Gly 
            580                 585                 590         


Tyr Val Ala Gly Val Trp Ser Leu Glu Asp Ala Cys Thr Leu Val Ser 
        595                 600                 605             


Ala Arg Ala Arg Leu Met Gln Ala Leu Pro Ala Gly Gly Ala Met Val 
    610                 615                 620                 


Ala Val Pro Val Ser Glu Glu Arg Ala Arg Ala Val Leu Val Asp Gly 
625                 630                 635                 640 


Val Glu Ile Ala Ala Val Asn Gly Pro Ala Ser Val Val Leu Ser Gly 
                645                 650                 655     


Asp Glu Ser Ala Val Leu Arg Val Ala Glu Gly Leu Gly Arg Trp Thr 
            660                 665                 670         


Arg Leu Ser Ala Ser His Ala Phe His Ser Val Arg Met Glu Pro Met 
        675                 680                 685             


Leu Glu Glu Phe Arg Gln Val Ala Ser Glu Leu Thr Tyr Arg Glu Pro 
    690                 695                 700                 


Arg Ile Val Met Ala Ala Gly Glu Gln Val Thr Thr Pro Glu Tyr Trp 
705                 710                 715                 720 


Val Arg Gln Val Arg Asp Thr Val Arg Phe Gly Asp Gln Val Ala Ala 
                725                 730                 735     


Phe Gly Asp Ala Val Phe Leu Glu Ile Gly Pro Asp Arg Thr Leu Ser 
            740                 745                 750         


Arg Leu Ile Asp Gly Ile Pro Thr Leu His Gly Asp Asp Glu Gln His 
        755                 760                 765             


Ala Val Val Ala Ala Leu Ala Glu Leu His Val Gln Gly Val Pro Ile 
    770                 775                 780                 


Asp Trp Ser Ser Ile Leu Gly Val Asn Pro Ala Arg Val Asp Leu Pro 
785                 790                 795                 800 


Thr Tyr Ala Phe Gln His Glu Arg Tyr Trp Met Val Ile Gln Glu Leu 
                805                 810                 815     


Ser Pro Glu Ala Leu Leu Lys Ile Val Arg Asp Ser Ala Ala Met Met 
            820                 825                 830         


Leu Gly His Pro Asn Thr Asp Ala Ile Ala Ala Thr Thr Ala Phe Arg 
        835                 840                 845             


Asp Leu Gly Val Asp Ser Leu Ile Ala Val Glu Leu Arg Asn Ser Leu 
    850                 855                 860                 


Ala Lys Ala Thr Gly Leu Arg Leu Pro Ala Thr Leu Val Phe Asp Tyr 
865                 870                 875                 880 


Pro Thr Pro Thr Val Leu Ala Gly Arg Leu 
                885                 890 


<210>  8
<211>  895
<212>  PRT
<213>  Streptomyces malaysiensis

<400>  8

Glu Pro Leu Ala Ile Val Gly Met Ala Cys Arg Leu Pro Gly Gly Val 
1               5                   10                  15      


Ser Ser Pro Glu Asp Leu Trp Arg Leu Val Glu Ser Gly Thr Asp Ala 
            20                  25                  30          


Ile Thr Asp Phe Pro Thr Asp Arg Gly Trp Asp Thr Asp Asp Leu Phe 
        35                  40                  45              


Asp Pro Asp Pro Asp Thr Pro Gly Lys Thr Tyr Thr Val His Gly Gly 
    50                  55                  60                  


Phe Leu Asp Asp Val Ala Gly Phe Asp Ala Ser Phe Phe Gly Ile Ser 
65                  70                  75                  80  


Pro Arg Glu Ala Gln Ala Met Asp Pro Gln Gln Arg Leu Val Leu Glu 
                85                  90                  95      


Ala Ala Trp Glu Ala Phe Glu Arg Ala Gly Ile Glu Pro Gly Ser Val 
            100                 105                 110         


Arg Gly Ser Asp Thr Gly Val Phe Met Gly Ala Tyr Pro Gly Gly Tyr 
        115                 120                 125             


Gly Ile Gly Val Asp Leu Gly Gly Phe Gly Ala Thr Ala Gly Ala Gly 
    130                 135                 140                 


Ser Val Leu Ser Gly Arg Leu Ser Tyr Phe Phe Gly Leu Glu Gly Pro 
145                 150                 155                 160 


Ala Met Thr Val Asp Thr Ala Cys Ser Ser Ser Leu Val Ala Leu His 
                165                 170                 175     


Gln Ala Gly Ser Ala Leu Arg Gln Gly Glu Cys Ser Leu Ala Leu Val 
            180                 185                 190         


Gly Gly Val Thr Val Ile Ala Asn Pro Gln Ile Phe Val Glu Phe Ser 
        195                 200                 205             


Arg Gln Arg Gly Leu Ala Ala Asp Gly Arg Cys Lys Ala Phe Ala Asp 
    210                 215                 220                 


Ser Ala Asp Gly Thr Gly Trp Ser Glu Gly Val Gly Val Leu Leu Val 
225                 230                 235                 240 


Glu Arg Leu Ser Asp Ala Gln Ala Arg Gly His Asn Ile Leu Ala Val 
                245                 250                 255     


Val Arg Gly Ser Ala Val Asn Gln Asp Gly Ala Ser Asn Gly Leu Thr 
            260                 265                 270         


Ala Pro Asn Gly Pro Ser Gln Gln Arg Val Ile Arg Gln Ala Leu Ala 
        275                 280                 285             


Asn Ala Gly Leu Ala Gly Ala Glu Val Asp Val Val Glu Ala His Gly 
    290                 295                 300                 


Thr Gly Thr Thr Leu Gly Asp Pro Ile Glu Ala Gln Ala Val Ile Ala 
305                 310                 315                 320 


Thr Tyr Gly Gln Asp Arg Asp Gln Pro Val Leu Leu Gly Ser Leu Lys 
                325                 330                 335     


Ser Asn Leu Gly His Thr Gln Ala Ala Ala Gly Val Ser Gly Val Ile 
            340                 345                 350         


Lys Met Val Met Ala Leu Gln Asn Gly Val Val Pro Arg Thr Leu His 
        355                 360                 365             


Ala Asp Gln Pro Ser Arg His Ile Asp Trp Thr Ala Gly Ala Val Glu 
    370                 375                 380                 


Leu Val Thr Glu Asn Gln Pro Trp Pro Glu Leu Gly Arg Pro Arg Arg 
385                 390                 395                 400 


Ala Ala Val Ser Ala Phe Gly Val Ser Gly Thr Asn Ala His Val Ile 
                405                 410                 415     


Leu Glu Ser Ala Pro Ala Gln Pro Val Pro Pro Val Asp Thr Pro Val 
            420                 425                 430         


Ser Ala Val Thr Ala Gly Val Val Pro Leu Pro Ile Ser Ala Arg Thr 
        435                 440                 445             


Val Pro Ala Leu Ala Asp Leu Glu Asp Arg Leu Arg Ala Tyr Leu Thr 
    450                 455                 460                 


Ala Thr Pro Glu Thr Asp Leu Pro Ala Val Ala Ser Thr Leu Ala Thr 
465                 470                 475                 480 


Thr Arg Ser Val Phe Glu His Arg Ala Val Leu Leu Gly Glu Asp Thr 
                485                 490                 495     


Val Thr Gly Thr Ala Ile Pro Asp Pro Arg Ile Val Phe Val Phe Ser 
            500                 505                 510         


Gly Gln Gly Ser Gln Arg Val Gly Met Gly Glu Glu Leu Ala Ala Ala 
        515                 520                 525             


Phe Pro Leu Phe Ala Arg Leu His Arg Gln Val Trp Asp Leu Leu Asp 
    530                 535                 540                 


Val Pro Asp Leu Asp Val Asp Asp Thr Gly Tyr Val Gln Pro Ala Leu 
545                 550                 555                 560 


Phe Ala Leu Gln Val Ala Leu Phe Gly Leu Leu Glu Ser Trp Gly Val 
                565                 570                 575     


Arg Pro Gln Ala Val Ile Gly His Ser Val Gly Glu Val Ala Ala Gly 
            580                 585                 590         


Tyr Val Ala Gly Val Trp Ser Leu Glu Asp Ala Cys Thr Leu Val Ser 
        595                 600                 605             


Ala Arg Ala Arg Leu Met Gln Ala Leu Pro Ala Gly Gly Ala Met Val 
    610                 615                 620                 


Ala Val Pro Val Ser Glu Glu Gln Ala Arg Ala Val Leu Val Asp Gly 
625                 630                 635                 640 


Val Glu Ile Ala Ala Val Asn Gly Pro Ala Ser Val Val Leu Ser Gly 
                645                 650                 655     


Asp Glu Ala Ala Val Leu Arg Val Ala Glu Gly Leu Gly Arg Trp Thr 
            660                 665                 670         


Arg Leu Ser Ala Ser His Ala Phe His Ser Val Arg Met Glu Pro Met 
        675                 680                 685             


Leu Glu Glu Phe Arg Gln Val Val Ser Arg Leu Thr Tyr Arg Glu Pro 
    690                 695                 700                 


Arg Ile Val Met Ala Ala Gly Glu Gln Val Thr Thr Pro Glu Tyr Trp 
705                 710                 715                 720 


Val Arg Gln Val Arg Glu Thr Val Arg Phe Gly Asp Gln Val Ala Ala 
                725                 730                 735     


Phe Gly Asp Ala Val Phe Leu Glu Ile Gly Pro Asp Arg Thr Leu Ser 
            740                 745                 750         


Arg Leu Ile Asp Gly Ile Ala Met Leu Asp Gly Asp Asp Glu Val Arg 
        755                 760                 765             


Ala Ala Val Ala Ala Leu Ala Val Met His Val Gln Gly Val Gly Val 
    770                 775                 780                 


Asp Trp Pro Ala Ile Leu Gly Thr Thr Thr Gly Arg Val Leu Asp Leu 
785                 790                 795                 800 


Pro Thr Tyr Ala Phe Gln His Glu Arg Tyr Trp Met Ala Asn Asn Gly 
                805                 810                 815     


Arg Pro Ala Asp Leu Thr Pro Glu Ala Leu Leu Lys Val Val Arg Asp 
            820                 825                 830         


Ser Ala Ala Met Val Leu Gly His Ala Asn Ala Asp Thr Val Pro Ala 
        835                 840                 845             


Ala Thr Ala Phe Gln Glu Leu Gly Leu Asp Ser Leu Ile Ala Val Glu 
    850                 855                 860                 


Leu Arg Asn Ser Leu Ala Lys Ala Thr Gly Leu Arg Leu Pro Ala Thr 
865                 870                 875                 880 


Met Val Phe Asp Tyr Pro Thr Pro Ala Ala Leu Ala Gly Arg Leu 
                885                 890                 895 


<210>  9
<211>  899
<212>  PRT
<213>  Streptomyces malaysiensis

<400>  9

Glu Pro Leu Ala Ile Val Gly Met Ala Cys Arg Leu Pro Gly Gly Val 
1               5                   10                  15      


Ser Ser Pro Glu Asp Leu Trp Arg Leu Val Glu Ser Gly Phe Asp Ala 
            20                  25                  30          


Ile Thr Gly Phe Pro Thr Asp Arg Gly Trp Asp Val Asp Asn Leu Tyr 
        35                  40                  45              


Asp Pro Asp Pro Asp Ala Pro Gly Lys Ser Thr Thr Leu His Gly Gly 
    50                  55                  60                  


Phe Leu Asp Asp Val Ala Gly Phe Asp Ala Ser Phe Phe Gly Ile Ser 
65                  70                  75                  80  


Pro Arg Glu Ala Val Ala Met Asp Pro Gln Gln Arg Leu Ala Met Glu 
                85                  90                  95      


Val Ser Trp Glu Ala Phe Glu Arg Ala Gly Ile Glu Pro Gly Ser Val 
            100                 105                 110         


Arg Gly Ser Asp Thr Gly Val Phe Met Gly Ala Tyr Pro Gly Gly Tyr 
        115                 120                 125             


Gly Ile Gly Ala Glu Leu Gly Gly Phe Met Leu Thr Gly Arg Ala Gly 
    130                 135                 140                 


Ser Val Leu Ala Gly Arg Val Ser Tyr Phe Phe Gly Leu Glu Gly Pro 
145                 150                 155                 160 


Ala Met Thr Val Asp Thr Ala Cys Ser Ser Ser Leu Val Ala Leu His 
                165                 170                 175     


Gln Ala Ala Tyr Ala Leu Arg Gln Gly Glu Cys Ser Leu Ala Leu Val 
            180                 185                 190         


Gly Gly Val Thr Val Met Pro Thr Pro Val Met Phe Val Glu Phe Ser 
        195                 200                 205             


Gln Gln Gln Asn Leu Ala Asp Asp Gly Arg Cys Lys Ala Phe Ala Asp 
    210                 215                 220                 


Ser Ala Asp Gly Thr Gly Trp Ser Glu Gly Val Gly Val Leu Leu Val 
225                 230                 235                 240 


Glu Arg Leu Ser Asp Ala Gln Ala Arg Gly His Asn Ile Leu Ala Val 
                245                 250                 255     


Val Arg Gly Ser Ala Val Asn Gln Asp Gly Ala Ser Asn Gly Leu Thr 
            260                 265                 270         


Ala Pro Asn Gly Pro Ser Gln Gln Arg Val Ile Arg Ser Ala Leu Thr 
        275                 280                 285             


Ser Ala Gly Leu Thr Thr Ala Asp Val Asp Val Val Glu Ala His Gly 
    290                 295                 300                 


Thr Gly Thr Thr Leu Gly Asp Pro Ile Glu Ala Gln Ala Val Leu Ala 
305                 310                 315                 320 


Thr Tyr Gly Gln Asp Arg Asp Gln Pro Val Leu Leu Gly Ser Leu Lys 
                325                 330                 335     


Ser Asn Leu Gly His Thr Gln Ala Ala Ala Gly Val Ser Gly Val Ile 
            340                 345                 350         


Lys Met Val Met Ala Leu Gln Asn Gly Val Val Pro Arg Thr Leu His 
        355                 360                 365             


Val Glu Glu Pro Ser Arg His Val Asp Trp Thr Ala Gly Ala Val Glu 
    370                 375                 380                 


Leu Val Thr Glu Asn Gln Ser Trp Pro Glu Thr Gly Arg Ala Arg Arg 
385                 390                 395                 400 


Ala Ala Val Ser Ser Phe Gly Phe Ser Gly Thr Asn Ala His Val Ile 
                405                 410                 415     


Leu Glu Ser Ala Pro Ala Gln Pro Val Pro Pro Met Asp Thr Pro Ala 
            420                 425                 430         


Pro Thr Val Thr Thr Gly Val Val Pro Leu Pro Ile Ser Ala Lys Ser 
        435                 440                 445             


Leu Pro Ala Leu Ala Asp Leu Glu Asp Gln Leu Arg Ala Tyr Leu Thr 
    450                 455                 460                 


Ala Thr Pro Glu Thr Asp Leu Pro Ala Val Ala Ser Thr Leu Ala Met 
465                 470                 475                 480 


Thr Arg Ser Val Phe Glu His Arg Ala Val Leu Leu Gly Glu Glu Thr 
                485                 490                 495     


Val Thr Gly Thr Ala Ile Pro Asp Pro Arg Ile Val Phe Val Phe Ser 
            500                 505                 510         


Gly Gln Gly Ser Gln Arg Val Gly Met Gly Glu Glu Leu Ala Ala Ala 
        515                 520                 525             


Phe Pro Leu Phe Ala Arg Leu His Arg Gln Val Trp Asp Leu Leu Asp 
    530                 535                 540                 


Val Pro Asp Leu Asp Val Asp Asp Thr Gly Tyr Val Gln Pro Ala Leu 
545                 550                 555                 560 


Phe Ala Leu Gln Val Ala Leu Phe Gly Leu Leu Glu Ser Trp Gly Val 
                565                 570                 575     


Arg Pro Gln Ala Val Ile Gly His Ser Val Gly Glu Val Ala Ala Gly 
            580                 585                 590         


Tyr Val Ala Gly Val Trp Ser Leu Glu Asp Ala Cys Thr Leu Val Ser 
        595                 600                 605             


Ala Arg Ala Arg Leu Met Gln Ala Leu Pro Ala Gly Gly Ala Met Val 
    610                 615                 620                 


Ala Val Pro Val Ser Glu Glu Gln Ala Arg Ala Ala Leu Val Asp Gly 
625                 630                 635                 640 


Val Glu Ile Ala Ala Val Asn Gly Pro Ala Ser Val Val Leu Ser Gly 
                645                 650                 655     


Asp Glu Ala Ala Val Leu Arg Val Ala Glu Gly Leu Gly Arg Trp Thr 
            660                 665                 670         


Arg Leu Ser Ala Ser His Ala Phe His Ser Val Arg Met Glu Pro Met 
        675                 680                 685             


Leu Glu Glu Phe Gly Gln Val Ala Ser Glu Leu Thr Tyr Gln Glu Pro 
    690                 695                 700                 


Arg Ile Val Met Ala Ala Gly Glu Gln Val Thr Thr Pro Glu Tyr Trp 
705                 710                 715                 720 


Val Arg Gln Val Arg Asp Thr Val Arg Phe Gly Asp Gln Val Ala Ala 
                725                 730                 735     


Phe Gly Asp Ala Val Phe Leu Glu Ile Gly Pro Asp Arg Thr Leu Ser 
            740                 745                 750         


Arg Leu Ile Asp Gly Ile Ala Met Leu Asp Gly Asp Asp Glu Val Arg 
        755                 760                 765             


Ala Ala Val Ala Ala Leu Ala Glu Leu His Val Gln Gly Val Pro Ile 
    770                 775                 780                 


Asp Trp Pro Ala Ile Leu Gly Thr Thr Thr Gly Arg Val Leu Asp Leu 
785                 790                 795                 800 


Pro Thr Tyr Ala Phe Gln His Gln Arg Tyr Trp Ala Ala Ser Thr Trp 
                805                 810                 815     


Leu Ala Gly Leu Ala Pro Glu Glu Arg Glu Gly Ala Leu Met Lys Val 
            820                 825                 830         


Val Arg Asp Thr Ala Ala Val Val Leu Gly His Ala Asp Ala Gly Thr 
        835                 840                 845             


Ile Pro Val Thr Ala Ala Phe Lys Asp Leu Gly Leu Asp Ser Leu Thr 
    850                 855                 860                 


Ala Val Glu Leu Arg Asn Ser Leu Ala Lys Ser Thr Gly Leu Arg Leu 
865                 870                 875                 880 


Pro Ala Thr Met Val Phe Asp Tyr Pro Thr Pro Ala Ser Leu Ala Ala 
                885                 890                 895     


Arg Leu Asp 
            


<210>  10
<211>  867
<212>  PRT
<213>  Micromonospora A92-306401

<400>  10

Glu Pro Leu Ala Ile Val Gly Met Ala Cys Arg Leu Pro Gly Gly Val 
1               5                   10                  15      


Glu Ser Pro Glu Asp Leu Trp Arg Leu Val Glu Ser Gly Thr Asp Ala 
            20                  25                  30          


Ile Ser Gly Phe Pro Ala Asp Arg Gly Trp Ala Asp Leu Ser Leu Arg 
        35                  40                  45              


Gly Gly Phe Leu Gly Asp Ala Ala His Phe Asp Ala Ala Phe Phe Gly 
    50                  55                  60                  


Ile Ser Pro Arg Glu Ala Leu Ala Met Asp Pro Gln Gln Arg Leu Ile 
65                  70                  75                  80  


Leu Glu Ala Ser Trp Glu Ala Phe Glu Arg Ala Gly Ile Glu Pro Gly 
                85                  90                  95      


Ser Val Arg Gly Ser Asp Thr Gly Val Phe Met Gly Ala Phe Ser Gly 
            100                 105                 110         


Gly Tyr Gly Ala Gly Ala Asp Leu Ala Gly Phe Gly Val Thr Ala Gly 
        115                 120                 125             


Ala Val Ser Val Leu Ser Gly Arg Val Ser Tyr Leu Phe Gly Leu Glu 
    130                 135                 140                 


Gly Pro Ala Val Thr Val Asp Thr Ala Cys Ser Ser Ser Leu Val Ala 
145                 150                 155                 160 


Leu His Gln Ala Gly His Ala Leu Arg Gln Gly Glu Cys Ser Leu Ala 
                165                 170                 175     


Leu Val Gly Gly Val Thr Val Met Pro Thr Pro Asp Ile Phe Val Glu 
            180                 185                 190         


Phe Ser Arg Gln Gly Gly Leu Ala Ser Asp Gly Arg Cys Lys Ala Phe 
        195                 200                 205             


Ala Asp Ala Ala Asp Gly Thr Ser Trp Ser Glu Gly Ala Gly Val Leu 
    210                 215                 220                 


Val Val Glu Arg Leu Ser Asp Ala Glu Arg Arg Gly His Thr Val Leu 
225                 230                 235                 240 


Ala Leu Val Arg Gly Ser Ala Val Asn Gln Asp Gly Ala Ser Asn Gly 
                245                 250                 255     


Leu Thr Ala Pro Asn Gly Pro Ser Gln Gln Arg Val Ile Gln Ala Ala 
            260                 265                 270         


Leu Ala Asn Ala Gly Leu Thr Pro His Glu Val Asp Val Val Glu Ala 
        275                 280                 285             


His Gly Thr Gly Thr Arg Leu Gly Asp Pro Ile Glu Ala Gln Ala Val 
    290                 295                 300                 


Ile Ala Thr Tyr Gly Arg Asp Arg Glu His Pro Leu Leu Leu Gly Ser 
305                 310                 315                 320 


Leu Lys Ser Asn Val Gly His Thr Gln Ala Ala Ser Gly Val Ser Gly 
                325                 330                 335     


Leu Ile Lys Met Val Met Ala Leu Arg Arg Gly Thr Val Pro Arg Thr 
            340                 345                 350         


Leu His Val Asp Glu Pro Ser Arg His Val Asp Trp Thr Ala Gly Ala 
        355                 360                 365             


Val Gln Leu Ala Ile Glu Asn Gln Pro Trp Pro Glu Thr Gly Arg Pro 
    370                 375                 380                 


Arg Arg Ala Ala Val Ser Ser Phe Gly Val Ser Gly Thr Asn Ala His 
385                 390                 395                 400 


Val Ile Leu Glu Gly Val Pro Glu Glu Pro Ala Asp Ser Glu Glu Pro 
                405                 410                 415     


Ala Gly Leu Thr Pro Leu Leu Ile Ser Ala Lys Thr Pro Ala Ala Leu 
            420                 425                 430         


Ala Glu Phe Glu Asp Arg Leu Arg Ala Arg Leu Thr Thr Glu Pro Asn 
        435                 440                 445             


Leu Ser Ala Val Ala Ser Thr Leu Val Arg Thr Arg Ser Leu Phe Asp 
    450                 455                 460                 


His Arg Ala Val Leu Leu Asp Gly Glu Thr Val Ser Gly Met Ala Glu 
465                 470                 475                 480 


Pro Asp Pro Arg Val Val Phe Val Phe Ser Gly Gln Gly Ser Gln Arg 
                485                 490                 495     


Ala Gly Met Gly Asp Asp Leu Ala Ala Ala Phe Pro Val Phe Ala Lys 
            500                 505                 510         


Ile Arg Gln Gln Val Trp Asp Leu Leu Asp Ile Pro Asp Leu Pro Val 
        515                 520                 525             


Asp Glu Thr Gly His Ala Gln Pro Ala Leu Phe Ala Leu Gln Val Ala 
    530                 535                 540                 


Leu Phe Gly Leu Leu Asp Ser Trp Gly Val Arg Pro Asp Ala Leu Val 
545                 550                 555                 560 


Gly His Ser Ile Gly Glu Leu Ala Ala Gly Tyr Val Ala Gly Ile Trp 
                565                 570                 575     


Ser Leu Glu Asp Ala Cys Ala Leu Val Ser Ala Arg Ala Arg Leu Met 
            580                 585                 590         


Glu Thr Leu Pro Pro Gly Gly Val Met Val Ala Val Pro Val Ser Glu 
        595                 600                 605             


Glu Gln Ala Arg Ala Val Leu Thr Asp Gly Val Glu Ile Ala Ala Val 
    610                 615                 620                 


Asn Gly Pro Ala Ser Val Val Leu Ser Gly Glu Glu Thr Ala Val Leu 
625                 630                 635                 640 


Gln Ala Ala Ala Ala Leu Gly Gly Arg Ser Lys Arg Leu Ala Thr Ser 
                645                 650                 655     


His Ala Phe His Ser Ala Arg Met Glu Pro Met Leu Asp Glu Phe Arg 
            660                 665                 670         


Ala Val Ala Glu Gln Leu Thr Tyr Gly Ser Pro Arg Ile Pro Met Ala 
        675                 680                 685             


Val Gly Asp Gly Pro Asp Tyr Trp Val Arg Gln Val Arg Asp Thr Val 
    690                 695                 700                 


Arg Phe Gly Glu Gln Val Ala Ala His Asp Gly Ala Ile Phe Val Glu 
705                 710                 715                 720 


Leu Gly Pro Asp Gly Ser Leu Ala Arg Leu Val Asp Gly Ile Ala Val 
                725                 730                 735     


Leu Asp Arg Glu Asp Glu Pro Arg Ala Ala Leu Thr Ala Leu Ala Arg 
            740                 745                 750         


Leu His Val Arg Gly Val Lys Val Asp Trp Pro Ile Ala Ala Gly Arg 
        755                 760                 765             


Arg Glu Leu Asp Leu Pro Thr Tyr Pro Phe Gln Arg Gln Arg Tyr Trp 
    770                 775                 780                 


Ala Glu Thr Pro Thr Ala Arg Arg Ala Pro Thr Asp Leu Leu Thr Leu 
785                 790                 795                 800 


Val Arg Asp Thr Thr Ala Thr Val Leu Gly Tyr Pro Asp Asn Thr Ala 
                805                 810                 815     


Val Thr Pro Thr Thr Ala Phe Thr Asp Leu Gly Ile Asp Ser Leu Thr 
            820                 825                 830         


Ala Ile Glu Leu Arg Asn Asn Met Ala Thr Thr Thr Gly Leu Arg Leu 
        835                 840                 845             


Pro Ala Thr Leu Val Phe Asp Tyr Pro Thr Pro Ala Thr Leu Ala Ala 
    850                 855                 860                 


Arg Leu Asp 
865         


<210>  11
<211>  901
<212>  PRT
<213>  Micromonospora A92-306401

<400>  11

Glu Pro Leu Ala Ile Ile Gly Met Ala Cys Arg Leu Pro Gly Gly Val 
1               5                   10                  15      


Thr Thr Pro Glu Asp Leu Trp Gln Leu Val Glu Thr Gly Thr Asp Ala 
            20                  25                  30          


Ile Ser Gly Phe Pro Thr Asp Arg Gly Trp Asp Val Glu Ser Leu Tyr 
        35                  40                  45              


Asp Pro Asp Pro Asp Ala Ala Gly Lys Ser Tyr Cys Val Glu Gly Gly 
    50                  55                  60                  


Phe Leu Asp Ala Val Ala Asp Phe Asp Ala Ser Phe Phe Gly Ile Ser 
65                  70                  75                  80  


Pro Arg Glu Ala Leu Ala Met Asp Pro Gln Gln Arg Leu Ile Leu Glu 
                85                  90                  95      


Thr Ser Trp Glu Ala Phe Glu Arg Ala Gly Ile Asp Pro Ala Asp Ala 
            100                 105                 110         


Arg Gly Ser Asp Thr Gly Val Phe Met Gly Ala Phe Thr Ser Gly Tyr 
        115                 120                 125             


Gly Ala Asp Leu Glu Gly Phe Gly Gly Thr Ala Gly Ala Leu Ser Val 
    130                 135                 140                 


Leu Ser Gly Arg Val Ser Tyr Phe Phe Gly Leu Glu Gly Pro Ala Ala 
145                 150                 155                 160 


Thr Val Asp Thr Ala Cys Ser Ser Ser Leu Val Ala Leu His Gln Ala 
                165                 170                 175     


Gly Tyr Ser Leu Arg His Gly Glu Cys Ser Leu Ala Leu Val Gly Gly 
            180                 185                 190         


Val Thr Val Met Ala Thr Pro Arg Thr Phe Val Glu Phe Ser Arg Gln 
        195                 200                 205             


Arg Gly Leu Ala Ser Asp Gly Arg Cys Lys Ala Phe Gly Asp Thr Ala 
    210                 215                 220                 


Asp Gly Thr Gly Trp Ser Glu Gly Val Gly Val Leu Leu Val Glu Arg 
225                 230                 235                 240 


Leu Ser Asp Ala Glu Arg Asn Gly His Arg Val Leu Ala Val Val Arg 
                245                 250                 255     


Ser Ser Ala Val Asn Gln Asp Gly Ala Ser Asn Gly Leu Thr Ala Pro 
            260                 265                 270         


Asn Gly Pro Ser Gln Gln Arg Val Ile Gln Ala Ala Leu Asp Asn Ala 
        275                 280                 285             


Gly Leu Ala Pro Gln Asp Val Asp Val Val Glu Ala His Gly Thr Gly 
    290                 295                 300                 


Thr Thr Leu Gly Asp Pro Ile Glu Ala Gln Ala Val Ile Ala Thr Tyr 
305                 310                 315                 320 


Gly Gln Asn Arg Glu Gln Pro Leu Leu Leu Gly Ser Leu Lys Ser Asn 
                325                 330                 335     


Val Gly His Thr Gln Ala Ala Ala Gly Val Ser Gly Val Ile Lys Met 
            340                 345                 350         


Ile Met Ala Leu Arg His Gly Val Val Pro Arg Thr Leu His Val Asp 
        355                 360                 365             


Glu Pro Ser Arg His Val Asp Trp Thr Ala Gly Ala Val His Leu Val 
    370                 375                 380                 


Arg Glu Asn Gln Pro Trp Pro Asp Val Asp Arg Pro Arg Arg Ala Gly 
385                 390                 395                 400 


Val Ser Ser Phe Gly Val Ser Gly Thr Asn Ala His Ile Ile Leu Glu 
                405                 410                 415     


Ser Pro Pro Ser Gln Pro Ala Pro Glu Pro Ala Pro Ala Leu Ser Pro 
            420                 425                 430         


Leu Val Ile Ser Ala Lys Thr Pro Gln Ala Leu Ala Ala Tyr Glu Asp 
        435                 440                 445             


Arg Leu Arg Thr Tyr Leu Thr Ala Ala Pro Ser Thr Asp Ala Arg Ala 
    450                 455                 460                 


Leu Ala Val Thr Arg Ser Leu Phe Glu His Arg Ala Val Leu Leu Gly 
465                 470                 475                 480 


Glu Asp Thr Val Thr Gly Thr Ala Leu Thr Glu Pro Arg Val Val Phe 
                485                 490                 495     


Val Phe Pro Gly Gln Gly Trp Gln Trp Leu Gly Met Gly Ala Ala Leu 
            500                 505                 510         


Met Glu Ser Val Val Phe Ala Glu Arg Met Ala Glu Cys Ala Ala Ala 
        515                 520                 525             


Leu Ser Glu Phe Val Asp Trp Asn Leu Ile Thr Val Leu Asn Asp Pro 
    530                 535                 540                 


Ala Val Ile Asp Gln Val Asp Val Val Gln Pro Ala Cys Trp Ala Val 
545                 550                 555                 560 


Met Val Ser Leu Ala Ala Val Trp Gln Ala Ala Gly Val Arg Pro Asp 
                565                 570                 575     


Ala Val Ile Gly His Ser Gln Gly Glu Ile Ala Ala Ala Cys Val Ala 
            580                 585                 590         


Gly Ala Ile Ser Leu Arg Asp Ala Ala Arg Ile Val Ala Leu Arg Ser 
        595                 600                 605             


Arg Leu Ile Ser Glu Arg Leu Gly Lys Gly Ala Met Ala Ser Ile Thr 
    610                 615                 620                 


Leu Pro Ala Asp Gln Ile Thr Leu Ala Glu Gly Ala Trp Ile Ala Ala 
625                 630                 635                 640 


Tyr Asn Gly Pro Thr Ser Thr Val Val Ala Gly Thr Pro Gln Ala Ile 
                645                 650                 655     


Glu Gln Met His Gly Glu Arg Val Arg Arg Ile Ala Val Asp Tyr Ala 
            660                 665                 670         


Ser His Thr Pro His Val Glu Gln Ile Arg Ala Glu Leu Leu Asp Leu 
        675                 680                 685             


Thr Thr Asp Val Ser Ser Gln Thr Pro Thr Leu Pro Trp Tyr Ser Thr 
    690                 695                 700                 


Val Asp Gly Thr Trp Ile Asp Ser Pro Leu Asp Gly Asp Tyr Trp Tyr 
705                 710                 715                 720 


Arg Asn Leu Arg Gln Pro Val Gly Phe His Pro Ala Val Gln Thr Leu 
                725                 730                 735     


Gln Ala Leu Gly Glu Thr Val Phe Val Glu Val Ser Ala Ser Pro Val 
            740                 745                 750         


Leu Leu Pro Ala Met Asp Asp Ala Val Thr Ile Ala Thr Leu Arg Arg 
        755                 760                 765             


Asp Glu Gly Thr Leu Thr Arg Met His Thr Ala Leu Ala Glu Ala His 
    770                 775                 780                 


Val Leu Gly Val Thr Ile Asp Trp Pro Thr Val Leu Gly Val Thr Thr 
785                 790                 795                 800 


Arg His Val Asp Leu Pro Thr Tyr Ala Phe Gln Arg Gln Arg Tyr Trp 
                805                 810                 815     


Val Ala Glu Leu Ala Ser Leu Gly Pro Ala Glu Arg Glu Arg Ala Leu 
            820                 825                 830         


Arg Lys Leu Val Ser Asp Thr Ala Ala Gly Ile Leu Gly His Ala Asp 
        835                 840                 845             


Ser Gly Thr Val Pro Val Thr Ala Ala Phe Arg Glu Leu Gly Val Asp 
    850                 855                 860                 


Ser Leu Thr Ala Val Glu Leu Arg Asn Gly Leu Ala Lys Ala Thr Gly 
865                 870                 875                 880 


Leu Arg Leu Pro Ala Thr Met Val Phe Asp Tyr Pro Thr Pro Gln Ala 
                885                 890                 895     


Leu Ala Asp Arg Leu 
            900     


<210>  12
<211>  905
<212>  PRT
<213>  Micromonospora A92-306401

<400>  12

Glu Pro Leu Ala Ile Val Gly Met Ala Cys Arg Leu Pro Gly Gly Val 
1               5                   10                  15      


Ser Ser Pro Glu Asp Leu Trp Arg Leu Val Glu Ser Gly Thr Asp Ala 
            20                  25                  30          


Ile Ala Asp Phe Pro Ala Asp Arg Gly Trp Asp Val Glu Ser Leu Tyr 
        35                  40                  45              


Asp Pro Asp Pro Asp Ala Ala Gly Lys Ser Tyr Cys Val Arg Gly Gly 
    50                  55                  60                  


Phe Leu Ala Ala Ala Ala Glu Phe Asp Ala Ala Phe Phe Gly Ile Ser 
65                  70                  75                  80  


Pro Arg Glu Ala Leu Ala Met Asp Pro Gln Gln Arg Leu Val Leu Glu 
                85                  90                  95      


Thr Ser Trp Glu Ala Phe Glu Arg Ala Gly Ile Glu Pro Gly Ser Val 
            100                 105                 110         


Arg Gly Ser Asp Thr Gly Val Phe Met Gly Ala Phe Ala Gly Gly Tyr 
        115                 120                 125             


Gly Ala Ala Val Glu Gly Phe Gly Ala Thr Ala Gly Ala Thr Ser Val 
    130                 135                 140                 


Leu Ser Gly Arg Val Ser Tyr Phe Phe Gly Leu Gln Gly Pro Ala Ile 
145                 150                 155                 160 


Thr Val Asp Thr Ala Cys Ser Ser Ser Leu Val Ala Leu His Gln Ala 
                165                 170                 175     


Gly Tyr Ser Leu Arg Gln Gly Glu Cys Ser Met Ala Leu Val Gly Gly 
            180                 185                 190         


Val Thr Val Met Ala Thr Pro Gln Ser Phe Val Glu Phe Ser Arg Gln 
        195                 200                 205             


Arg Gly Leu Ala Pro Asp Gly Arg Cys Lys Ala Phe Ala Asp Thr Ala 
    210                 215                 220                 


Asp Gly Thr Gly Trp Ser Glu Gly Val Gly Val Leu Leu Val Glu Arg 
225                 230                 235                 240 


Leu Ser Asp Ala Glu Arg Asn Gly His Arg Val Leu Ala Val Val Arg 
                245                 250                 255     


Ser Ser Ala Val Asn Gln Asp Gly Ala Ser Asn Gly Leu Ser Ala Pro 
            260                 265                 270         


Asn Gly Pro Ala Gln Gln Arg Val Ile Arg Gln Ala Leu Ala Asn Ala 
        275                 280                 285             


Gly Leu Ala Ala Ala Asp Val Asp Val Val Glu Ala His Gly Thr Gly 
    290                 295                 300                 


Thr Thr Leu Gly Asp Pro Ile Glu Ala Gln Ala Val Leu Ala Thr Tyr 
305                 310                 315                 320 


Gly Gln Asp Arg Glu Arg Pro Leu Leu Leu Gly Ser Leu Lys Ser Asn 
                325                 330                 335     


Val Gly His Thr Gln Ala Ala Ala Gly Val Ser Gly Val Ile Lys Met 
            340                 345                 350         


Val Met Ala Leu Arg His Gly Val Val Pro Arg Thr Leu His Val Asp 
        355                 360                 365             


Glu Pro Ser Arg His Val Asp Trp Thr Ala Gly Ala Val His Leu Val 
    370                 375                 380                 


Thr Glu Asn Gln Pro Trp Pro Asp Thr Asp Arg Pro Arg Arg Ala Gly 
385                 390                 395                 400 


Val Ser Ser Phe Gly Val Ser Gly Thr Asn Ala His Val Ile Ile Glu 
                405                 410                 415     


Gly Ser Pro Thr Ser Ser Pro Val Ala Glu Pro Ser Gly Asp Val Leu 
            420                 425                 430         


Pro Leu Val Val Ser Ala Lys Thr Pro Gln Ala Leu Thr Ala Tyr Glu 
        435                 440                 445             


Asp Arg Leu Arg Ala Phe Leu Ala Ala Ala Pro Val Thr Asp Thr Arg 
    450                 455                 460                 


Ala Val Ala Ser Thr Leu Ala Val Thr Arg Ser Leu Phe Glu His Arg 
465                 470                 475                 480 


Ala Val Leu Val Gly Asp Asn Thr Val Thr Gly Thr Ala Leu Ala Glu 
                485                 490                 495     


Pro Arg Val Val Phe Val Phe Pro Gly Gln Gly Trp Gln Trp Leu Gly 
            500                 505                 510         


Met Gly Ala Ala Leu Met Glu Ser Val Val Phe Ala Glu Arg Met Ala 
        515                 520                 525             


Glu Cys Ala Ala Ala Leu Gly Glu Phe Val Asp Trp Asp Leu Leu Ala 
    530                 535                 540                 


Val Leu Asp Asp Ser Ala Val Val Asp Arg Val Asp Val Val Gln Pro 
545                 550                 555                 560 


Ala Cys Trp Ala Val Met Val Ser Leu Ala Ala Val Trp Gln Asp Ala 
                565                 570                 575     


Gly Val Arg Pro Asp Ala Val Ile Gly His Ser Gln Gly Glu Ile Ala 
            580                 585                 590         


Ala Ala Cys Val Ala Gly Ala Ile Ser Leu Arg Asp Ala Ala Arg Ile 
        595                 600                 605             


Val Ala Leu Arg Ser Arg Leu Ile Ser Glu Arg Leu Gly Lys Gly Ala 
    610                 615                 620                 


Met Ala Ser Ile Thr Leu Pro Ala Asp Gln Ile Thr Leu Ala Glu Gly 
625                 630                 635                 640 


Ala Trp Ile Ala Ala Tyr Asn Gly Pro Ala Ser Thr Val Val Ala Gly 
                645                 650                 655     


Thr Pro Asp Ala Ile Glu Gln Met Gln Gly Asp Arg Val Arg Arg Ile 
            660                 665                 670         


Ala Val Asp Tyr Ala Ser His Thr Pro His Val Glu Gln Ile Arg Ala 
        675                 680                 685             


Glu Leu Leu Asp Leu Thr Ala Glu Val Gly Ser Arg Thr Pro Thr Val 
    690                 695                 700                 


Pro Trp Tyr Ser Thr Val Asp Gly Thr Trp Ile Asp Ser Pro Leu Asp 
705                 710                 715                 720 


Gly Glu Tyr Trp Tyr Arg Asn Leu Arg Gln Pro Val Gly Phe His Pro 
                725                 730                 735     


Ala Val Gln Thr Leu Gln Ala Leu Gly Glu Thr Val Phe Val Glu Val 
            740                 745                 750         


Ser Ala Ser Pro Val Leu Leu Pro Ala Met Asp Asp Ala Val Thr Val 
        755                 760                 765             


Ala Thr Leu Arg Arg Asp Glu Gly Thr Leu Thr Arg Met His Thr Ala 
    770                 775                 780                 


Leu Ala Glu Ser His Val Leu Gly Val Ser Ile Asp Trp Pro His Val 
785                 790                 795                 800 


Leu Gly Asp Thr Gly Glu Arg Met Leu Asp Leu Pro Thr Tyr Ala Phe 
                805                 810                 815     


Glu Arg His Arg Tyr Trp Ser Thr Ala Arg Arg Asn Pro Ser Ile Ala 
            820                 825                 830         


Pro Asp Asp Leu Leu Thr Val Val Arg Asp Ser Ala Ala Val Val Leu 
        835                 840                 845             


Gly Tyr Ala Asp Gly Gly Ala Val Pro Val Thr Gly Ala Phe Lys Asp 
    850                 855                 860                 


Leu Gly Ile Asp Ser Leu Thr Ala Val Glu Leu Arg Asn Gly Leu Ala 
865                 870                 875                 880 


Lys Ala Thr Gly Leu Arg Leu Pro Ala Thr Val Ala Phe Asp Tyr Pro 
                885                 890                 895     


Thr Pro Gln Ala Leu Ala Ala Arg Leu 
            900                 905 


<210>  13
<211>  865
<212>  PRT
<213>  Micromonospora A92-306401

<400>  13

Glu Pro Leu Ala Ile Val Gly Met Ala Cys Arg Leu Pro Gly Gly Val 
1               5                   10                  15      


Ser Ser Pro Glu Asp Leu Trp Arg Leu Val Glu Ser Gly Thr Asp Ala 
            20                  25                  30          


Ile Thr Gly Phe Pro Ala Asp Arg Gly Trp Ala Glu Tyr Ser Phe Gln 
        35                  40                  45              


Gly Gly Phe Leu Asp Asp Ala Ala Asp Phe Asp Ala Ala Phe Phe Gly 
    50                  55                  60                  


Ile Ser Pro Arg Glu Ala Leu Ala Met Asp Pro Gln Gln Arg Leu Val 
65                  70                  75                  80  


Leu Glu Thr Ala Trp Glu Ala Phe Glu Arg Ala Gly Ile Glu Pro Gly 
                85                  90                  95      


Ser Leu Arg Gly Ser Asp Thr Gly Val Phe Met Gly Ala Tyr Pro Gly 
            100                 105                 110         


Gly Tyr Gly Ile Gly Ala Asp Arg Ala Gly Phe Gly Ala Thr Ala Gly 
        115                 120                 125             


Ala Gly Ser Val Leu Ser Gly Arg Val Ser Tyr Phe Phe Gly Leu Glu 
    130                 135                 140                 


Gly Pro Ala Val Thr Val Asp Thr Ala Cys Ser Ser Ser Leu Val Ala 
145                 150                 155                 160 


Leu His Gln Ala Gly His Ala Leu Arg Leu Gly Glu Cys Ser Leu Ala 
                165                 170                 175     


Leu Val Gly Gly Val Thr Val Met Ala Thr Pro Asp Thr Phe Val Glu 
            180                 185                 190         


Phe Ser Arg Gln Gly Gly Leu Ala Ala Asp Gly Arg Ser Lys Ala Phe 
        195                 200                 205             


Ala Asp Ser Ala Asp Gly Ala Gly Phe Ala Glu Gly Ala Gly Val Leu 
    210                 215                 220                 


Leu Val Glu Arg Leu Ser Asp Ala Gln Arg His Gly His Gln Val Leu 
225                 230                 235                 240 


Ala Leu Val Arg Gly Ser Ala Val Asn Gln Asp Gly Ala Ser Asn Gly 
                245                 250                 255     


Leu Thr Ala Pro Asn Gly Pro Ser Gln Gln Arg Val Ile Gln Ala Ala 
            260                 265                 270         


Leu Asp Asn Ala Gly Leu Thr Ala Ala Glu Val Asp Val Val Glu Ala 
        275                 280                 285             


His Gly Thr Gly Thr Thr Leu Gly Asp Pro Ile Glu Ala Gln Ala Val 
    290                 295                 300                 


Ile Ala Ala Tyr Gly Gln Gly Arg Gly Glu Pro Leu Leu Leu Gly Ser 
305                 310                 315                 320 


Ile Lys Ser Asn Val Gly His Thr Gln Ala Ala Ala Gly Val Ser Gly 
                325                 330                 335     


Val Ile Lys Val Val Met Ala Leu Arg His Gly Val Val Pro Arg Thr 
            340                 345                 350         


Leu His Val Asp Glu Pro Ser Arg His Val Asp Trp Thr Ala Gly Ala 
        355                 360                 365             


Val Arg Leu Ala Thr Glu Asn Gln Ser Trp Pro Glu Thr Gly Arg Pro 
    370                 375                 380                 


Arg Arg Ala Gly Val Ser Ser Phe Gly Ile Ser Gly Thr Asn Ala His 
385                 390                 395                 400 


Val Ile Leu Glu Gly Val Pro Glu Glu Pro Ala Gly His Glu Glu Pro 
                405                 410                 415     


Ala Gly Leu Thr Pro Leu Leu Ile Ser Ala Lys Thr Pro Ala Ala Leu 
            420                 425                 430         


Ala Glu Phe Glu Asp Arg Leu Arg Ala Tyr Leu Thr Thr Glu Pro Ser 
        435                 440                 445             


Leu Pro Ala Val Ala Ser Thr Leu Ala Arg Thr Arg Ser Leu Phe Asp 
    450                 455                 460                 


His Arg Ala Val Val Leu Asp Gly Asp Val Val Arg Gly Val Ala Glu 
465                 470                 475                 480 


Pro Asp Arg Arg Val Val Phe Val Phe Ser Gly Gln Gly Ser Gln Arg 
                485                 490                 495     


Ala Gly Met Gly Asp Asp Leu Ala Ala Ala Phe Pro Val Phe Ala Lys 
            500                 505                 510         


Ile Arg Gln Gln Val Trp Asp Gln Leu Asp Ile Pro Asp Leu Pro Val 
        515                 520                 525             


Asp Gln Thr Gly Tyr Ala Gln Pro Ala Leu Phe Ala Leu Gln Val Ala 
    530                 535                 540                 


Leu Phe Gly Leu Leu Asp Ser Trp Gly Val Arg Pro Asp Ala Leu Val 
545                 550                 555                 560 


Gly His Ser Ile Gly Glu Leu Ala Ala Gly Tyr Val Ala Gly Ile Trp 
                565                 570                 575     


Ser Leu Glu Asp Ala Cys Ala Leu Val Ser Ala Arg Ala Arg Leu Met 
            580                 585                 590         


Gln Ala Leu Pro Pro Gly Gly Val Met Val Ala Val Pro Val Ser Glu 
        595                 600                 605             


Gln Gln Ala Arg Gly Ala Leu Thr Asp Gly Val Glu Ile Ala Ala Val 
    610                 615                 620                 


Asn Gly Pro Ala Ser Val Val Leu Ser Gly Asp Glu Ala Ala Val Leu 
625                 630                 635                 640 


Arg Ala Ala Ala Ala Leu Gly Gly Arg Ser Lys Arg Leu Ala Thr Ser 
                645                 650                 655     


His Ala Phe His Ser Ala Arg Met Glu Pro Met Leu Asp Glu Phe Arg 
            660                 665                 670         


Met Val Ala Glu Arg Leu Ser Tyr Gly Ser Pro Arg Ile Ser Met Ala 
        675                 680                 685             


Val Gly Asp Gly Pro Asp Tyr Trp Val Arg Gln Val Arg Glu Ala Val 
    690                 695                 700                 


Arg Phe Gly Glu Gln Val Ala Ala His Asp Gly Ala Val Phe Val Glu 
705                 710                 715                 720 


Leu Gly Pro Asp Gly Ser Leu Ala Arg Leu Ile Asp Gly Ile Ala Met 
                725                 730                 735     


Leu Asp Arg Asp Asp Glu Pro Arg Ala Ala Leu Thr Ala Leu Ala Arg 
            740                 745                 750         


Leu His Val Gln Gly Val Lys Val Asp Trp Pro Ile Gly Ala Gly Arg 
        755                 760                 765             


Arg Val Asp Leu Pro Thr Tyr Pro Phe Gln Arg Gln Arg Tyr Trp Ile 
    770                 775                 780                 


Asp Arg Pro Thr Ala Arg Arg Ala Pro Thr Asp Leu Leu Thr Leu Val 
785                 790                 795                 800 


Arg Asp Thr Ala Ala Thr Val Leu Gly Tyr Pro Asp Ser Ser Ala Val 
                805                 810                 815     


Pro Ala Thr Thr Ala Phe Lys Asp Leu Gly Val Asp Ser Leu Thr Ala 
            820                 825                 830         


Ile Glu Leu Arg Asn Gly Met Ala Thr Thr Thr Gly Leu Arg Leu Pro 
        835                 840                 845             


Ala Thr Leu Val Phe Asp Tyr Pro Thr Pro Ala Ala Leu Ala Ala Arg 
    850                 855                 860                 


Leu 
865 


<210>  14
<211>  898
<212>  PRT
<213>  Micromonospora A92-306401

<400>  14

Glu Pro Leu Ala Ile Val Gly Met Ala Cys Arg Leu Pro Gly Gly Val 
1               5                   10                  15      


Ser Ser Pro Glu Asp Leu Trp Arg Leu Val Glu Ser Gly Thr Asp Ala 
            20                  25                  30          


Ile Ser Gly Phe Pro Thr Asp Arg Gly Trp Ala Glu His Ser Phe Gln 
        35                  40                  45              


Gly Gly Phe Leu Asp Gly Ala Gly Asp Phe Asp Ala Pro Phe Phe Gly 
    50                  55                  60                  


Ile Ser Pro Arg Glu Ala Arg Val Met Asp Pro Gln Gln Arg Leu Val 
65                  70                  75                  80  


Leu Glu Ala Ser Trp Glu Ala Phe Glu Arg Ala Gly Ile Glu Pro Gly 
                85                  90                  95      


Thr Val Arg Gly Ser Asp Thr Gly Val Phe Met Gly Ala Tyr Ser Gly 
            100                 105                 110         


Gly Tyr Ala Ala Gly Ala Asp Leu Ala Gly Phe Ala Ala Thr Ala Gly 
        115                 120                 125             


Ala Gly Ser Val Leu Ser Gly Arg Val Ser Tyr Phe Phe Gly Leu Glu 
    130                 135                 140                 


Gly Pro Ala Val Thr Val Asp Thr Ala Cys Ser Ser Ser Leu Val Ala 
145                 150                 155                 160 


Leu His Gln Ala Gly His Ala Leu Arg Gln Gly Glu Cys Ser Leu Ala 
                165                 170                 175     


Leu Val Gly Gly Val Thr Val Met Ala Thr Pro Asp Leu Phe Val Glu 
            180                 185                 190         


Phe Ala Arg Gln Gln Gly Leu Ala Ala Asp Gly Arg Cys Lys Ala Phe 
        195                 200                 205             


Ala Asp Asn Ala Asp Gly Thr Gly Trp Ser Glu Gly Val Gly Val Leu 
    210                 215                 220                 


Leu Val Glu Arg Leu Ser Asp Ala Glu Arg Asn Gly His Arg Val Leu 
225                 230                 235                 240 


Ala Val Val Arg Ser Ser Ala Val Asn Gln Asp Gly Ala Ser Asn Gly 
                245                 250                 255     


Leu Thr Ala Pro Asn Gly Pro Ser Gln Gln Arg Val Ile Gln Ala Ala 
            260                 265                 270         


Leu Asp Asn Ala Gly Leu Thr Pro Ala Asp Ile Asp Val Val Glu Ala 
        275                 280                 285             


His Gly Thr Gly Thr Thr Leu Gly Asp Pro Ile Glu Ala Gln Ala Val 
    290                 295                 300                 


Ile Ala Thr Tyr Gly Gln Thr Arg Glu Gln Pro Leu Leu Leu Gly Ser 
305                 310                 315                 320 


Leu Lys Ser Asn Val Gly His Thr Gln Ala Ala Ala Gly Val Ser Gly 
                325                 330                 335     


Val Ile Lys Met Val Met Ala Leu Arg His Gly Val Val Pro Arg Thr 
            340                 345                 350         


Leu His Val Asp Glu Pro Ser Arg His Val Asp Trp Thr Ala Gly Ala 
        355                 360                 365             


Val Gln Leu Ala Val Glu Asn Gln Pro Trp Pro Asn Thr Gly Arg Pro 
    370                 375                 380                 


Arg Arg Ala Gly Val Ser Ala Phe Gly Val Ser Gly Thr Asn Ala His 
385                 390                 395                 400 


Val Ile Ile Glu Gly Ser Pro Thr Pro Ser Pro Val Ala Glu Pro Ser 
                405                 410                 415     


Gly Asp Val Leu Pro Leu Val Ile Ser Ala Lys Thr Pro Gln Ala Leu 
            420                 425                 430         


Thr Ala Tyr Glu Asp Arg Leu Arg Thr Tyr Leu Asn Ala Thr Pro Glu 
        435                 440                 445             


Ile Asp Thr Arg Ala Val Ala Ser Thr Leu Ala Val Thr Arg Ser Leu 
    450                 455                 460                 


Phe Glu His Arg Ala Val Leu Leu Gly Asp Asn Thr Val Ser Gly Thr 
465                 470                 475                 480 


Ala Leu Thr Glu Pro Arg Val Val Phe Val Phe Pro Gly Gln Gly Trp 
                485                 490                 495     


Gln Trp Leu Gly Met Gly Ala Ala Leu Met Glu Ser Val Val Phe Ala 
            500                 505                 510         


Glu Arg Met Ala Glu Cys Ala Ala Ala Leu Ser Glu Phe Val Asp Trp 
        515                 520                 525             


Asn Leu Ile Thr Val Leu Asn Asp Pro Ala Val Val Asp Gln Val Asp 
    530                 535                 540                 


Val Val Gln Pro Ala Cys Trp Ala Val Met Val Ser Leu Ala Ala Val 
545                 550                 555                 560 


Trp Gln Asp Ala Gly Val Arg Pro Ala Ala Val Ile Gly His Ser Gln 
                565                 570                 575     


Gly Glu Ile Ala Ala Ala Cys Val Ala Gly Ala Ile Ser Leu Arg Asp 
            580                 585                 590         


Ala Ala Arg Ile Val Ala Leu Arg Ser Arg Leu Ile Gly Glu Arg Leu 
        595                 600                 605             


Gly Arg Gly Ala Met Ala Ser Val Ala Leu Pro Ala Asp Glu Ile Ala 
    610                 615                 620                 


Leu Val Asp Glu Val Trp Val Ala Ala Tyr Asn Gly Pro Ala Ser Thr 
625                 630                 635                 640 


Val Ile Ala Gly Ala Pro Asp Ala Ile Glu Gln Met Leu Gly Asp Arg 
                645                 650                 655     


Val Arg Arg Ile Ala Val Asp Tyr Ala Ser His Thr Pro Gln Val Glu 
            660                 665                 670         


Gln Ile Arg Ala Glu Leu Leu Asp Leu Thr Ala Glu Val Ser Ser Gln 
        675                 680                 685             


Ala Pro Thr Val Pro Trp Tyr Ser Thr Val Asp Gly Thr Trp Ile Asp 
    690                 695                 700                 


Gly Pro Leu Asp Ser Asp Tyr Trp Tyr Arg Asn Leu Arg Gln Pro Val 
705                 710                 715                 720 


Gly Phe His Pro Ala Val Glu Ala Leu Gly Gly Leu Gly Glu Thr Val 
                725                 730                 735     


Phe Val Glu Val Ser Ala Ser Pro Val Leu Leu Pro Ala Met Asp Asp 
            740                 745                 750         


Ala Val Thr Val Ala Thr Leu Arg Arg Asp Glu Gly Thr Leu Thr Arg 
        755                 760                 765             


Met His Thr Ala Leu Ala Glu Ala His Val Leu Gly Val Thr Ile Asp 
    770                 775                 780                 


Trp Pro Ala Val Val Gly Asp Thr Gly Glu Arg Met Leu Asp Leu Pro 
785                 790                 795                 800 


Thr Tyr Ala Phe Gln His His Arg Tyr Trp Thr Thr Ala Thr Ala Arg 
                805                 810                 815     


Leu Glu Gly Arg Thr Gly Ala Glu Lys His Arg Leu Leu Leu Asp Ile 
            820                 825                 830         


Val Leu Ala Asn Ala Ala Thr Val Leu Gly His Asp Thr Ala Asp Thr 
        835                 840                 845             


Ile Ala Ser Asp Lys Pro Phe Lys Asp Leu Gly Ile Asp Ser Leu Thr 
    850                 855                 860                 


Ala Val Glu Leu Arg Asn Ser Leu Ala Arg Ala Thr Glu Leu Arg Leu 
865                 870                 875                 880 


Pro Ala Thr Thr Ala Phe Asp Tyr Pro Thr Pro Glu Ala Leu Ala Thr 
                885                 890                 895     


Arg Leu 
        


<210>  15
<211>  867
<212>  PRT
<213>  Micromonospora A92-306401

<400>  15

Glu Pro Leu Ala Ile Val Gly Met Ala Cys Arg Leu Pro Gly Gly Val 
1               5                   10                  15      


Ser Ser Pro Glu Asp Leu Trp Arg Leu Val Glu Ser Gly Thr Asp Ala 
            20                  25                  30          


Ile Thr Gly Phe Pro Ala Asp Arg Gly Trp Pro Asp Asp Ser Arg Gln 
        35                  40                  45              


Gly Gly Phe Leu Asp Asp Ala Ala Asp Phe Asp Ala Ala Phe Phe Gly 
    50                  55                  60                  


Ile Ser Pro Arg Glu Ala Leu Ala Met Asp Pro Gln Gln Arg Leu Val 
65                  70                  75                  80  


Leu Glu Ala Ala Trp Glu Ala Phe Glu Arg Ala Gly Ile Glu Pro Gly 
                85                  90                  95      


Ser Leu Arg Gly Ser Asp Thr Gly Val Phe Met Gly Ala Tyr Pro Gly 
            100                 105                 110         


Gly Tyr Gly Ile Gly Ala Asp Gln Ala Gly Phe Gly Thr Thr Ala Gly 
        115                 120                 125             


Ala Gly Ser Val Leu Ser Gly Arg Val Ser Tyr Leu Phe Gly Leu Glu 
    130                 135                 140                 


Gly Pro Ala Val Thr Val Asp Thr Ala Cys Ser Ser Ser Leu Val Ala 
145                 150                 155                 160 


Leu His Gln Ala Gly His Ala Leu Arg Leu Gly Glu Cys Ser Leu Ala 
                165                 170                 175     


Leu Val Gly Gly Val Thr Val Met Gly Thr Pro Asp Ile Phe Ala Glu 
            180                 185                 190         


Phe Ser Arg Gln Gly Gly Leu Ala Ser Asp Gly Arg Cys Lys Pro Phe 
        195                 200                 205             


Ala Asp Ala Ala Asp Gly Thr Gly Trp Ala Glu Gly Val Gly Val Leu 
    210                 215                 220                 


Leu Val Glu Arg Leu Ser Asp Ala Glu Arg His Gly His Gln Val Leu 
225                 230                 235                 240 


Ala Val Val Arg Gly Ser Ala Val Asn Gln Asp Gly Ala Ser Asn Gly 
                245                 250                 255     


Leu Thr Ala Pro Asn Gly Pro Ser Gln Gln Arg Val Ile Gln Ser Ala 
            260                 265                 270         


Leu Ile Gln Ala Gly Leu Ala Pro His Glu Val Asp Val Val Glu Ala 
        275                 280                 285             


His Gly Thr Gly Thr Thr Leu Gly Asp Pro Ile Glu Ala Gln Ala Val 
    290                 295                 300                 


Ile Ala Ala Tyr Gly Gln Asp Arg Ala Gln Pro Leu Leu Leu Gly Ser 
305                 310                 315                 320 


Ile Lys Ser Asn Val Gly His Thr Gln Ala Ala Ala Gly Val Ser Gly 
                325                 330                 335     


Val Ile Lys Met Val Met Ala Leu Arg His Gly Val Val Pro Arg Thr 
            340                 345                 350         


Leu His Val Asp Glu Pro Ser Arg His Val Asp Trp Ser Ala Gly Ala 
        355                 360                 365             


Val Arg Leu Ala Thr Glu Ser Gln Pro Trp Pro Asp Thr Gly His Pro 
    370                 375                 380                 


Arg Arg Ala Gly Val Ser Ser Phe Gly Ile Ser Gly Thr Asn Ala His 
385                 390                 395                 400 


Val Ile Leu Glu Gly Val Pro Glu Glu Pro Ala Asp Thr Gly Glu Pro 
                405                 410                 415     


Ser Gly Leu Val Pro Leu Leu Leu Ser Ala Lys Thr Pro Ala Ala Leu 
            420                 425                 430         


Thr His Leu Glu Asp Arg Leu Arg Ala Tyr Leu Thr Thr Glu Pro Asn 
        435                 440                 445             


Leu Pro Ala Val Ala Ser Thr Leu Ala Gln Thr Arg Ser Leu Phe Asp 
    450                 455                 460                 


His Arg Ala Val Leu Leu Asp Gly Asp Val Val Arg Gly Val Ala Glu 
465                 470                 475                 480 


Pro Asp Arg Arg Val Val Phe Val Phe Ser Gly Gln Gly Ser Gln Arg 
                485                 490                 495     


Ala Gly Met Gly Asp Asp Leu Ala Ala Ala Phe Pro Val Phe Ala Lys 
            500                 505                 510         


Ile Arg Gln Gln Val Trp Asp Leu Leu Asp Ile Pro Asp Leu Pro Val 
        515                 520                 525             


Asp Glu Thr Gly His Ala Gln Pro Ala Leu Phe Ala Leu Gln Val Ala 
    530                 535                 540                 


Leu Phe Gly Leu Leu Asp Ser Trp Gly Val Arg Pro Asp Ala Leu Val 
545                 550                 555                 560 


Gly His Ser Ile Gly Glu Leu Ala Ala Gly Tyr Val Ala Gly Ile Trp 
                565                 570                 575     


Ser Leu Glu Asp Ala Cys Ala Leu Val Ser Ala Arg Ala Arg Leu Met 
            580                 585                 590         


Gln Ala Leu Pro Pro Gly Gly Val Met Val Ala Val Ser Val Ser Glu 
        595                 600                 605             


Glu Gln Ala Arg Ala Val Leu Thr Asp Gly Val Glu Ile Ala Ala Val 
    610                 615                 620                 


Asn Gly Pro Ala Ser Val Val Leu Ser Gly Glu Glu Thr Ala Val Leu 
625                 630                 635                 640 


Gln Ala Ala Ala Ala Leu Gly Gly Arg Ser Lys Arg Leu Ala Thr Ser 
                645                 650                 655     


His Ala Phe His Ser Ala Arg Met Glu Pro Met Leu Asp Glu Phe Arg 
            660                 665                 670         


Met Val Ala Glu Arg Leu Ser Tyr Gly Ser Pro Gln Ile Pro Met Ala 
        675                 680                 685             


Val Gly Asp Gly Pro Asp Tyr Trp Val Arg Gln Val Arg Glu Thr Val 
    690                 695                 700                 


Arg Phe Gly Glu Gln Val Ala Ala His Asp Gly Gly Ile Phe Val Glu 
705                 710                 715                 720 


Leu Gly Pro Asp Gly Ser Leu Ala Arg Leu Val Asp Gly Ile Ala Val 
                725                 730                 735     


Leu Asp Arg Asp Asp Glu Pro Arg Ala Ala Leu Thr Ala Leu Ala Arg 
            740                 745                 750         


Leu His Val Gln Gly Val Lys Val Asp Trp Pro Ile Ala Ala Gly Arg 
        755                 760                 765             


Arg Val Leu Asp Leu Pro Thr Tyr Pro Phe Gln His Gln Arg Tyr Trp 
    770                 775                 780                 


Ala Thr Arg Pro Ala Ala Arg Arg Ala Pro Thr Asp Leu Leu Thr Leu 
785                 790                 795                 800 


Val Arg Asp Thr Ala Ala Thr Val Leu Gly Tyr Pro Asp Ser Ser Ala 
                805                 810                 815     


Val Pro Ala Thr Thr Ala Phe Lys Asp Leu Gly Val Asp Ser Leu Thr 
            820                 825                 830         


Ala Val Glu Leu Arg Asn Asn Leu Ala Thr Ser Thr Gly Leu Arg Leu 
        835                 840                 845             


Pro Ala Thr Leu Val Phe Asp Tyr Pro Thr Pro Ala Thr Leu Ala Ala 
    850                 855                 860                 


Arg Leu Asp 
865         


<210>  16
<211>  868
<212>  PRT
<213>  Micromonospora A92-306401

<400>  16

Glu Pro Leu Ala Ile Val Gly Met Ala Cys Arg Leu Pro Gly Gly Val 
1               5                   10                  15      


Ser Thr Pro Glu Asp Leu Trp Gln Leu Val Glu Ser Gly Thr Asp Ala 
            20                  25                  30          


Ile Ser Gly Phe Pro Ala Asp Arg Gly Trp Asp Asp Tyr Pro Tyr Gln 
        35                  40                  45              


Gly Gly Phe Leu Thr Thr Ala Ala Asp Phe Asp Ala Ala Phe Phe Gly 
    50                  55                  60                  


Ile Ser Pro Arg Glu Ala Leu Ala Met Asp Pro Gln Gln Arg Leu Ile 
65                  70                  75                  80  


Leu Glu Ala Ser Trp Glu Ala Phe Glu Arg Ala Gly Ile Asn Pro Ala 
                85                  90                  95      


Asp Ala Arg Gly Ser Asp Thr Gly Val Phe Met Gly Ala Phe Ser Ala 
            100                 105                 110         


Gly Tyr Gly Asp Asp Arg Asp Asp Ser Pro Ala Thr Ala Gly Ala Val 
        115                 120                 125             


Ser Val Leu Ser Gly Arg Val Ser Tyr Phe Phe Gly Leu Glu Gly Pro 
    130                 135                 140                 


Ala Met Thr Val Asp Thr Ala Cys Ser Ser Ser Leu Val Ala Leu His 
145                 150                 155                 160 


Gln Ala Gly Tyr Ser Leu Arg His Gly Glu Cys Ser Met Ala Leu Val 
                165                 170                 175     


Gly Gly Val Thr Val Met Ala Thr Pro Arg Thr Phe Val Glu Phe Ala 
            180                 185                 190         


Arg Gln Gly Gly Leu Ala Glu Asp Gly Arg Cys Lys Ala Phe Ala Asp 
        195                 200                 205             


Thr Ala Asp Gly Thr Gly Trp Ala Glu Gly Val Gly Val Leu Leu Val 
    210                 215                 220                 


Glu Arg Leu Ser Asp Ala Glu Arg Asn Gly His Arg Val Leu Ala Val 
225                 230                 235                 240 


Val Arg Ser Ser Ala Val Asn Gln Asp Gly Ala Ser Asn Gly Leu Thr 
                245                 250                 255     


Ala Pro Asn Gly Pro Ser Gln Gln Arg Val Ile Gln Ala Ala Leu Asp 
            260                 265                 270         


Asn Ala Gly Leu Ala Pro Gln Asp Val Asp Val Val Glu Ala His Gly 
        275                 280                 285             


Thr Gly Thr Thr Leu Gly Asp Pro Ile Glu Ala Gln Ala Val Ile Ala 
    290                 295                 300                 


Thr Tyr Gly Gln Asn Arg Gln Gln Pro Leu Leu Leu Gly Ser Ile Lys 
305                 310                 315                 320 


Ser Asn Val Gly His Thr Gln Ala Ala Ala Gly Val Ser Gly Ile Ile 
                325                 330                 335     


Lys Met Ile Met Ala Leu Arg His Gly Val Val Pro Arg Thr Leu His 
            340                 345                 350         


Val Asp Glu Pro Ser Arg His Val Asp Trp Thr Ala Gly Ala Val Arg 
        355                 360                 365             


Leu Val Thr Glu Asn Gln Pro Trp Pro Asp Ala Asp Arg Pro Arg Arg 
    370                 375                 380                 


Ala Gly Val Ser Ser Phe Gly Ile Ser Gly Thr Asn Ala His Ile Ile 
385                 390                 395                 400 


Leu Glu Gly Val Pro Glu Glu Pro Ala Gln Pro Asp Glu Ser Pro Glu 
                405                 410                 415     


Leu Thr Pro Leu Val Ile Ser Ala Lys Thr Ala Pro Ala Leu Thr Gln 
            420                 425                 430         


Phe Glu Ala Arg Leu Arg Ser Tyr Leu Thr Thr Glu Pro Ala Leu Ser 
        435                 440                 445             


Ala Val Ala Ser Thr Leu Ala Gln Thr Arg Ser Leu Phe Asp His Arg 
    450                 455                 460                 


Ala Val Leu Leu Gly Gly Asp Thr Ile Thr Gly Val Ala Glu Pro Ser 
465                 470                 475                 480 


Pro Arg Val Val Phe Val Phe Ser Gly Gln Gly Ser Gln Arg Ala Gly 
                485                 490                 495     


Met Gly Asp Glu Leu Ala Ala Ala Phe Pro Val Phe Ala Lys Ile Arg 
            500                 505                 510         


Gln Gln Val Trp Asp Leu Leu Asp Ile Pro Asp Leu Pro Val Asp Glu 
        515                 520                 525             


Thr Gly His Ala Gln Pro Ala Leu Phe Ala Leu Gln Val Ala Leu Phe 
    530                 535                 540                 


Gly Leu Leu Asp Ser Trp Gly Val Arg Pro Asp Ala Leu Ile Gly His 
545                 550                 555                 560 


Ser Ile Gly Glu Leu Ala Ala Gly Tyr Val Ser Gly Ile Trp Ser Leu 
                565                 570                 575     


Glu Asp Ala Cys Ala Leu Val Ser Ala Arg Ala Arg Leu Met Gln Ala 
            580                 585                 590         


Ser Pro Pro Gly Gly Ala Met Val Ala Val Pro Val Ser Glu Gln Gln 
        595                 600                 605             


Ala Arg Ala Val Leu Thr Asp Gly Val Glu Leu Ala Ala Val Asn Gly 
    610                 615                 620                 


Pro Ser Ser Val Val Leu Ser Gly Asp Glu Thr Ala Val Leu Gln Ala 
625                 630                 635                 640 


Ala Ala Ala Leu Gly Gly Arg Ser Lys Arg Leu Ala Thr Ser His Ala 
                645                 650                 655     


Phe His Ser Ala Arg Met Glu Pro Met Leu Asp Glu Phe Arg Ala Val 
            660                 665                 670         


Ala Glu Gln Leu Ser Tyr Arg Ser Pro Gln Ile Pro Met Ala Val Gly 
        675                 680                 685             


Asp Gly Pro Glu Tyr Trp Val Arg Gln Val Arg Asp Thr Val Arg Phe 
    690                 695                 700                 


Gly Glu Gln Val Ala Ala His Asp Gly Ala Ile Phe Val Glu Leu Gly 
705                 710                 715                 720 


Pro Asp Gly Ser Leu Val Arg Leu Ile Asp Gly Ile Pro Met Leu Asp 
                725                 730                 735     


Arg Asp Asp Glu Pro Arg Ala Ala Leu Thr Ala Leu Ala Arg Leu His 
            740                 745                 750         


Val Arg Gly Val Asn Val Ala Trp Pro Ile Ala Ala Asp Arg Arg Glu 
        755                 760                 765             


Leu Asp Leu Pro Thr Tyr Pro Phe Gln Arg Glu Arg Tyr Trp Ser Thr 
    770                 775                 780                 


Ala Ser Leu Ser Ala Leu Ala Pro Ala Glu Arg Glu Gln Ala Leu Arg 
785                 790                 795                 800 


Lys Val Val Ser Asp Ser Ser Ala Met Val Leu Gly Tyr Ala Glu Gly 
                805                 810                 815     


Arg Ala Val Ala Pro Thr Ala Ala Phe Lys Asp Leu Gly Val Asp Ser 
            820                 825                 830         


Leu Thr Ala Val Glu Leu Arg Asn Ser Leu Thr Lys Ala Thr Gly Leu 
        835                 840                 845             


Arg Leu Pro Ala Thr Ile Val Phe Asp Tyr Pro Thr Pro Gly Ala Leu 
    850                 855                 860                 


Ala Val Arg Leu 
865             


<210>  17
<211>  882
<212>  PRT
<213>  Micromonospora A92-306401

<400>  17

Glu Pro Leu Ala Ile Val Gly Met Ala Cys Arg Leu Pro Gly Gly Val 
1               5                   10                  15      


Ser Ser Pro Glu Asp Leu Trp Arg Leu Val Glu Ser Gly Thr Asp Ala 
            20                  25                  30          


Ile Ser Arg Phe Pro Ala Asp Arg Gly Trp Asp Val Asp Gly Leu Tyr 
        35                  40                  45              


Asp Pro Asp Pro Asp Ala Pro Gly Lys Ser Tyr Ser Val Glu Gly Gly 
    50                  55                  60                  


Phe Leu Asp Ala Val Ala Asp Phe Asp Ala Ala Phe Phe Gly Ile Ser 
65                  70                  75                  80  


Pro Arg Glu Ala Leu Ala Met Asp Pro Gln Gln Arg Leu Ile Leu Glu 
                85                  90                  95      


Ala Ser Trp Glu Ala Phe Glu Arg Ala Gly Ile Glu Pro Gly Ser Leu 
            100                 105                 110         


Arg Gly Ser Asp Thr Gly Val Phe Met Gly Ala Tyr Ser Ser Gly Tyr 
        115                 120                 125             


Gly Ile Gly Ala Asp Ile Pro Gly Leu Gly Val Thr Ala Gly Ala Val 
    130                 135                 140                 


Ser Val Val Ser Gly Arg Val Ser Tyr Phe Phe Gly Leu Glu Gly Pro 
145                 150                 155                 160 


Ala Val Thr Val Asp Thr Ala Cys Ser Ser Ser Leu Val Ala Leu His 
                165                 170                 175     


Gln Ala Gly His Ala Leu Arg Arg Arg Glu Cys Ser Leu Ala Leu Val 
            180                 185                 190         


Gly Gly Val Thr Val Met Ala Thr Pro Phe Gly Phe Val Glu Phe Ser 
        195                 200                 205             


Arg Gln Arg Gly Leu Ala Ser Asp Gly Arg Cys Lys Ala Phe Ala Asp 
    210                 215                 220                 


Thr Ala Asp Gly Thr Ser Trp Ser Glu Gly Ala Gly Val Leu Val Val 
225                 230                 235                 240 


Glu Arg Leu Ser Asp Ala Glu Arg His Gly His Gln Val Leu Ala Val 
                245                 250                 255     


Val Arg Gly Ser Ala Val Asn Gln Asp Gly Ala Ser Asn Gly Leu Thr 
            260                 265                 270         


Ala Pro Asn Gly Pro Ser Gln Gln Arg Val Ile Gln Ala Ala Leu Ala 
        275                 280                 285             


Asn Ala Gly Leu Thr Pro His Glu Val Asp Val Val Glu Ala His Gly 
    290                 295                 300                 


Thr Gly Thr Arg Leu Gly Asp Pro Ile Glu Ala Gln Ala Val Ile Ala 
305                 310                 315                 320 


Thr Tyr Gly Gln Ala Arg Gly Glu Pro Leu Leu Leu Gly Ser Ile Lys 
                325                 330                 335     


Ser Asn Val Gly His Thr Gln Ala Ala Ala Gly Val Ser Gly Val Ile 
            340                 345                 350         


Lys Met Val Met Ala Leu Arg His Gly Val Val Pro Arg Thr Leu His 
        355                 360                 365             


Val Asp Glu Pro Thr Arg His Val Asp Trp Thr Thr Gly Ala Val Arg 
    370                 375                 380                 


Leu Ala Thr Glu Asn Gln Pro Trp Pro Glu Thr Glu Arg Pro Arg Arg 
385                 390                 395                 400 


Ala Gly Val Ser Ser Phe Gly Val Ser Gly Thr Asn Ala His Ile Ile 
                405                 410                 415     


Leu Glu Gly Val Ala Ala Glu Pro Ala Gln Pro Gly Glu Ser Pro Glu 
            420                 425                 430         


Leu Thr Pro Leu Leu Leu Ser Ala Lys Thr Pro Ala Ala Leu Thr His 
        435                 440                 445             


Leu Glu Asp Arg Leu Arg Ala Tyr Leu Thr Thr Glu Pro Asn Leu Pro 
    450                 455                 460                 


Ala Val Ala Ser Thr Leu Ala Gln Thr Arg Ser Leu Phe Asp His Arg 
465                 470                 475                 480 


Ala Val Leu Leu Gly Gly Glu Thr Val Thr Gly Val Ala Glu Pro Asp 
                485                 490                 495     


Pro Arg Val Val Phe Val Phe Ser Gly Gln Gly Ser Gln Arg Ala Gly 
            500                 505                 510         


Met Gly Asp Asp Leu Ala Ala Ala Phe Pro Ala Phe Ala Lys Ile Arg 
        515                 520                 525             


Gln Gln Val Trp Asp Gln Leu Asp Ile Pro Asn Leu Pro Val Asp Glu 
    530                 535                 540                 


Thr Gly His Ala Gln Pro Ala Leu Phe Ala Leu Gln Val Ala Leu Phe 
545                 550                 555                 560 


Gly Leu Leu Asp Ser Trp Gly Val Arg Pro Asp Ala Leu Val Gly His 
                565                 570                 575     


Ser Ile Gly Glu Leu Ala Ala Gly Tyr Val Ala Gly Ile Trp Ser Leu 
            580                 585                 590         


Glu Asp Ala Cys Ala Leu Val Ser Ala Arg Ala Arg Leu Met Gln Ala 
        595                 600                 605             


Leu Pro Pro Gly Gly Val Met Val Ala Val Ser Val Ser Glu Glu Gln 
    610                 615                 620                 


Ala Arg Ala Val Leu Thr Asp Gly Val Glu Ile Ala Ala Val Asn Gly 
625                 630                 635                 640 


Pro Ala Ser Val Val Leu Ser Gly Glu Glu Thr Ala Val Leu Gln Ala 
                645                 650                 655     


Ala Ala Ala Leu Gly Gly Arg Ser Lys Arg Leu Ala Thr Ser His Ala 
            660                 665                 670         


Phe His Ser Ala Arg Met Glu Pro Met Leu Asp Glu Phe Arg Ala Val 
        675                 680                 685             


Ala Glu Gln Leu Ser Tyr Gly Ser Pro Arg Ile Pro Met Ala Val Gly 
    690                 695                 700                 


Asp Gly Pro Asp Tyr Trp Val Arg Gln Val Arg Asp Thr Val Arg Phe 
705                 710                 715                 720 


Gly Glu Gln Val Ala Ala His Asp Gly Ala Ile Phe Val Glu Leu Gly 
                725                 730                 735     


Pro Asp Gly Ser Leu Ala Arg Leu Ile Asp Gly Ile Ala Val Leu Asp 
            740                 745                 750         


Arg Asp Asp Glu Pro Arg Ala Ala Leu Thr Ala Leu Ala Arg Leu His 
        755                 760                 765             


Val Arg Gly Val Lys Val Asp Trp Pro Ile Ala Ala Gly Arg Arg Glu 
    770                 775                 780                 


Leu Asp Leu Pro Thr Tyr Pro Phe Gln His Gln Arg Tyr Trp Ile Asp 
785                 790                 795                 800 


Ser Arg Pro Thr Ala Arg Arg Ala Pro Thr Asp Leu Leu Thr Leu Val 
                805                 810                 815     


Arg Asp Thr Thr Ala Thr Val Leu Gly Tyr Pro Asp Asn Thr Ala Val 
            820                 825                 830         


Thr Pro Thr Thr Ala Phe Thr Asp Leu Gly Ile Asp Ser Leu Thr Ala 
        835                 840                 845             


Ile Glu Leu Arg Asn Asn Met Ala Thr Thr Thr Gly Leu Arg Leu Pro 
    850                 855                 860                 


Ala Thr Leu Val Phe Asp Tyr Pro Thr Pro Ala Thr Leu Ala Ala Arg 
865                 870                 875                 880 


Leu Asp 
        


<210>  18
<211>  897
<212>  PRT
<213>  Micromonospora A92-306401

<400>  18

Glu Pro Leu Ala Ile Ile Gly Met Ala Cys Arg Leu Pro Gly Gly Val 
1               5                   10                  15      


Thr Thr Pro Glu Asp Leu Trp Gln Leu Val Glu Thr Gly Thr Asp Ala 
            20                  25                  30          


Ile Ser Ala Leu Pro Thr Asp Arg Gly Trp Ala Asp His Pro Tyr Gln 
        35                  40                  45              


Gly Gly Phe Leu Thr Thr Ala Ala Asp Phe Asp Ala Ala Phe Phe Gly 
    50                  55                  60                  


Ile Ser Pro Arg Glu Ala Leu Ala Met Asp Pro Gln Gln Arg Leu Ile 
65                  70                  75                  80  


Leu Glu Thr Ser Trp Glu Ala Phe Glu Arg Ala Gly Ile Asn Pro Ala 
                85                  90                  95      


Asp Ala His Gly Ser Asp Thr Gly Val Phe Met Gly Ala Tyr Ser Gly 
            100                 105                 110         


Gly Tyr Gly Ile Gly Ala Asp Leu Ala Gly Phe Gly Ala Thr Ala Gly 
        115                 120                 125             


Ala Thr Ser Val Leu Ser Gly Arg Val Ser Tyr Phe Phe Gly Leu Glu 
    130                 135                 140                 


Gly Pro Ala Ile Thr Val Asp Thr Ala Cys Ser Ser Ser Leu Val Ala 
145                 150                 155                 160 


Leu His Gln Ala Gly His Ala Leu Arg His Gly Glu Cys Ser Leu Ala 
                165                 170                 175     


Leu Val Gly Gly Val Thr Val Met Ala Thr Pro Asp Ile Phe Val Glu 
            180                 185                 190         


Phe Ala Arg Gln Arg Gly Leu Ala Ala Asp Gly Arg Cys Lys Ala Phe 
        195                 200                 205             


Ala Asp Thr Ala Asp Gly Thr Gly Trp Ala Glu Gly Val Gly Val Leu 
    210                 215                 220                 


Leu Val Glu Arg Leu Ser Asp Ala Glu Arg Asn Gly His Arg Val Leu 
225                 230                 235                 240 


Ala Val Val Arg Ser Ser Ala Val Asn Gln Asp Gly Ala Ser Asn Gly 
                245                 250                 255     


Leu Thr Ala Pro Asn Gly Pro Ser Gln Gln Arg Val Ile Gln Ala Ala 
            260                 265                 270         


Leu Asp Asn Ala Gly Leu Thr Pro Ala Asp Ile Asp Val Val Glu Ala 
        275                 280                 285             


His Gly Thr Gly Thr Thr Leu Gly Asp Pro Ile Glu Ala Gln Ala Leu 
    290                 295                 300                 


Ile Ala Thr Tyr Gly Gln Asn Arg Glu Gln Pro Leu Leu Leu Gly Ser 
305                 310                 315                 320 


Leu Lys Ser Asn Ile Gly His Thr Gln Ala Ala Ala Gly Val Ser Gly 
                325                 330                 335     


Val Ile Lys Met Val Met Ala Leu Gln His Gly Val Val Pro Arg Thr 
            340                 345                 350         


Leu His Val Asp Lys Pro Ser Arg His Val Asp Trp Thr Ala Gly Ala 
        355                 360                 365             


Val Arg Leu Leu Thr Glu Ser Gln Pro Trp Pro Asp Thr Asp Arg Pro 
    370                 375                 380                 


Arg Arg Ala Gly Val Ser Ser Phe Gly Val Ser Gly Thr Asn Ala His 
385                 390                 395                 400 


Val Ile Ile Glu Gly Ser Pro Thr Pro Ser Pro Val Ala Asp Pro Ser 
                405                 410                 415     


Gly Asp Val Leu Pro Leu Val Ile Ser Ala Lys Thr Pro Ala Ala Leu 
            420                 425                 430         


Ala Ala Tyr Glu Asp Arg Leu Arg Thr Tyr Leu Asn Ala Thr Pro Glu 
        435                 440                 445             


Ile Asp Thr Arg Ala Val Ala Ser Thr Leu Ala Val Thr Arg Ser Leu 
    450                 455                 460                 


Phe Glu His Arg Ala Val Leu Leu Gly Glu Asp Thr Val Ser Gly Thr 
465                 470                 475                 480 


Ala Leu Thr Glu Pro Arg Val Val Phe Val Phe Pro Gly Gln Gly Trp 
                485                 490                 495     


Gln Trp Leu Gly Met Gly Ala Ala Leu Met Glu Ser Val Val Phe Ala 
            500                 505                 510         


Glu Arg Met Thr Glu Cys Ala Thr Ala Leu Ser Glu Phe Val Asp Trp 
        515                 520                 525             


Asn Leu Ile Thr Val Leu Asn Asp Pro Ala Val Ile Asp Gln Val Asp 
    530                 535                 540                 


Val Val Gln Pro Ala Cys Trp Ala Val Met Val Ser Leu Ala Ala Val 
545                 550                 555                 560 


Trp Gln Ala Ala Gly Val Arg Pro Asp Ala Val Ile Gly His Ser Gln 
                565                 570                 575     


Gly Glu Ile Ala Ala Ala Cys Val Ala Gly Ala Ile Ser Leu Arg Asp 
            580                 585                 590         


Ala Ala Arg Ile Val Ala Leu Arg Ser Arg Leu Ile Ser Glu Arg Leu 
        595                 600                 605             


Gly Lys Gly Ala Met Ala Ser Ile Thr Leu Pro Ala Asp Gln Ile Thr 
    610                 615                 620                 


Leu Ala Glu Gly Ala Trp Ile Ala Ala Tyr Asn Gly Pro Thr Ser Thr 
625                 630                 635                 640 


Val Val Ala Gly Thr Pro Gln Ala Ile Glu Gln Met His Gly Glu Arg 
                645                 650                 655     


Val Arg Arg Ile Ala Val Asp Tyr Ala Ser His Thr Pro His Val Glu 
            660                 665                 670         


Gln Ile Arg Ala Glu Leu Leu Asp Leu Thr Thr Asp Val Ser Ser Gln 
        675                 680                 685             


Thr Pro Thr Leu Pro Trp Tyr Ser Thr Val Asp Gly Thr Trp Ile Asp 
    690                 695                 700                 


Ser Pro Leu Asp Gly Asp Tyr Trp Tyr Arg Asn Leu Arg Gln Pro Val 
705                 710                 715                 720 


Gly Phe His Pro Ala Val Gln Thr Leu Gln Ala Leu Gly Glu Thr Val 
                725                 730                 735     


Phe Val Glu Val Ser Ala Ser Pro Val Leu Leu Pro Ala Met Asp Asp 
            740                 745                 750         


Ala Val Thr Ile Ala Thr Leu Arg Arg Asp Glu Gly Thr Leu Thr Arg 
        755                 760                 765             


Met His Thr Ala Leu Ala Glu Ala His Val Leu Gly Val Thr Ile Asp 
    770                 775                 780                 


Trp Pro His Val Leu Gly Asp Thr Gly Glu Arg Met Leu Asp Leu Pro 
785                 790                 795                 800 


Thr Tyr Ala Phe Gln His His Arg Tyr Trp Thr Thr Ala Ala Arg Leu 
                805                 810                 815     


Thr Gly Arg Thr Thr Ala Ala Gln His Arg Leu Met Leu Asp Phe Val 
            820                 825                 830         


Leu Gly Asn Val Ala Ala Val Leu Gly His Gly Ser Ala Gly Asp Val 
        835                 840                 845             


Ala Pro Asp Lys Pro Phe Lys Glu Leu Gly Met Asp Ser Leu Thr Ser 
    850                 855                 860                 


Val Glu Leu Arg Asn Ser Leu Ala Lys Ala Thr Gly Gln Arg Leu Pro 
865                 870                 875                 880 


Ala Thr Ile Val Phe Asp His Pro Thr Ala Asp Ala Leu Ala Thr Tyr 
                885                 890                 895     


Leu 
    


<210>  19
<211>  945
<212>  PRT
<213>  Micromonospora A92-306401

<400>  19

Glu Pro Ile Ala Ile Val Ser Met Ala Cys Arg Val Pro Gly Gly Val 
1               5                   10                  15      


Thr Ser Pro Glu Gly Leu Trp Arg Leu Val Glu Ser Gly Thr Asp Ala 
            20                  25                  30          


Ile Ser Glu Phe Pro Gly Asp Arg Gly Trp Asp Val Ala Asn Leu Tyr 
        35                  40                  45              


Ser Pro Asp Pro Asp Ala Pro Gly Lys Ser Tyr Ser Leu Gln Gly Gly 
    50                  55                  60                  


Phe Leu Asp Gly Ala Ala Ala Phe Asp Ala Ser Phe Phe Gly Ile Ser 
65                  70                  75                  80  


Pro Arg Glu Ala Leu Gly Met Asp Pro Gln Gln Arg Leu Leu Leu Glu 
                85                  90                  95      


Thr Ser Trp Glu Ala Val Glu Arg Ala Arg Ile Asp Pro Lys Ser Leu 
            100                 105                 110         


Arg Gly Arg Asp Val Gly Val Tyr Val Gly Gly Ala Ala Gln Gly Tyr 
        115                 120                 125             


Gly Leu Gly Ala Ala Glu Ala Gln Arg Asp Asn Leu Ile Thr Gly Gly 
    130                 135                 140                 


Ser Ile Ser Leu Leu Ser Gly Arg Leu Ser Tyr Ala Leu Gly Leu Glu 
145                 150                 155                 160 


Gly Pro Gly Leu Thr Val Asp Thr Ala Cys Ser Ser Ser Leu Val Ala 
                165                 170                 175     


Leu His Leu Ala Ala Gln Ala Leu Arg Gln Gly Glu Cys Ser Leu Ala 
            180                 185                 190         


Leu Val Ser Gly Val Ser Val Met Pro Thr Pro Asp Val Phe Val Glu 
        195                 200                 205             


Phe Ser Arg Gln Arg Gly Leu Ala Ala Asp Gly Arg Cys Lys Ser Phe 
    210                 215                 220                 


Ala Ala Ala Ala Asp Gly Thr Ser Trp Ser Glu Gly Val Gly Val Leu 
225                 230                 235                 240 


Leu Leu Glu Arg Leu Ser Asp Ala Arg Arg Leu Gly His Glu Ile Leu 
                245                 250                 255     


Ala Val Val Arg Gly Thr Ala Val Asn Ser Asp Gly Ala Ser Asn Gly 
            260                 265                 270         


Leu Thr Ala Pro Asn Gly Ala Ser Gln Gln Arg Val Ile Arg Gln Ala 
        275                 280                 285             


Leu Ala Ser Ala Gly Leu Gly Pro Ala Asp Val Asp Ala Val Glu Ala 
    290                 295                 300                 


His Gly Thr Gly Thr Lys Leu Gly Asp Pro Ile Glu Ala Glu Ala Ile 
305                 310                 315                 320 


Leu Ala Thr Tyr Gly Lys Asp Arg Pro Thr Pro Val Trp Leu Gly Ser 
                325                 330                 335     


Leu Lys Ser Asn Ile Gly His Thr Met Ala Ala Ser Gly Val Leu Gly 
            340                 345                 350         


Val Ile Lys Met Val Glu Ser Met Arg His Gly Val Leu Pro Arg Thr 
        355                 360                 365             


Leu His Val Asp Glu Pro Ser Pro His Val Asp Trp Ala Ala Gly Asp 
    370                 375                 380                 


Val Ala Leu Leu Thr Ser Asn Gln Pro Trp Pro Ala Gly Arg Lys Pro 
385                 390                 395                 400 


Arg Arg Ala Gly Val Ser Ser Phe Gly Leu Ser Gly Thr Asn Ala His 
                405                 410                 415     


Val Val Leu Glu Gln Tyr Arg Met Pro Ala Ala Pro Val Thr Thr Lys 
            420                 425                 430         


Glu Ala Gly Pro Leu Pro Trp Val Leu Ser Ala Gln Thr Pro Glu Ala 
        435                 440                 445             


Leu Arg Glu Arg Ala Gly Gln Leu Ala Thr Ala Leu Ala Gly Asp Pro 
    450                 455                 460                 


Ala Trp His Pro Leu Asp Val Gly Tyr Ser Leu Ala Ala Thr Arg Ser 
465                 470                 475                 480 


Thr Phe Ala His Arg Ala Val Val Val Gly Gly Asp Arg Glu Phe Val 
                485                 490                 495     


Arg Thr Leu Gly Lys Leu Ala Asp Gly Ala Gly Trp Pro Gly Leu Thr 
            500                 505                 510         


Thr Gly Val Ala Lys Ser Arg Arg Ile Ala Phe Met Phe Asp Gly Gln 
        515                 520                 525             


Gly Thr Gln Arg Leu Ala Met Gly Gln Gly Leu Tyr Ala Arg Phe Pro 
    530                 535                 540                 


Ala Phe Thr Arg Thr Trp Asp Thr Val Ser Ala Glu Phe Ala Lys His 
545                 550                 555                 560 


Leu Asp His Thr Leu Thr Asp Val Tyr Leu Gly Gly Gly Gly Thr Ala 
                565                 570                 575     


Ala Ala Glu Leu Val Asp Asp Pro Leu Tyr Ala Gln Ala Gly Ile Phe 
            580                 585                 590         


Ala Val Glu Val Ala Leu Val Glu Leu Leu Ala Glu Trp Gly Val Arg 
        595                 600                 605             


Pro Asp Val Val Thr Gly His Ser Ile Gly Glu Ala Ala Ala Ala Tyr 
    610                 615                 620                 


Thr Ala Gly Met Phe Ser Leu Ala Asp Val Thr Ala Leu Ile Thr Ala 
625                 630                 635                 640 


Arg Gly Ala Ala Leu Arg Ser Ala Pro Pro Gly Ala Met Leu Ala Leu 
                645                 650                 655     


Arg Ala Gly Glu Pro Glu Val Arg Asp Phe Leu Asp Arg Thr Gly Ala 
            660                 665                 670         


Ala Leu Asp Val Ala Ala Val Asn Gly Pro Ala Ala Val Val Val Ser 
        675                 680                 685             


Gly Ala Pro Asp Ala Val Ala Gly Phe Ala Ser Ala Trp Thr Ala Ser 
    690                 695                 700                 


Gly Arg Glu Cys Arg Gln Leu Lys Val Arg Arg Ala Phe His Ser Arg 
705                 710                 715                 720 


His Val Glu Gly Val Leu Gly Asp Phe Arg Thr Val Leu Lys Ser Leu 
                725                 730                 735     


Thr Phe Arg Thr Pro Ala Leu Pro Ile Val Ser Thr Val Thr Gly Arg 
            740                 745                 750         


Leu Ile Asp Pro Ala Glu Met Gly Thr Pro Glu Tyr Trp Leu Ser Gln 
        755                 760                 765             


Val Arg Gln Pro Val Arg Phe Gln Asp Ala Val Gly Glu Leu Ala Gly 
    770                 775                 780                 


Gln Gly Val Ser Ala Phe Leu Glu Val Gly Pro Ser Gly Thr Leu Ala 
785                 790                 795                 800 


Ser Ala Gly Met Glu Cys Leu Asp Ala Ser Phe His Ala Leu Leu Arg 
                805                 810                 815     


Pro Arg Pro Ala Glu Asp Ile Gly Val Leu Thr Ala Leu Ala Glu Leu 
            820                 825                 830         


Tyr Ala Gly Gly Thr Ala Val Asp Trp Ala Thr Val Leu Ala Gly Gly 
        835                 840                 845             


Arg Pro Val Asp Leu Pro Val Tyr Pro Phe Gln His Gln Ser Tyr Trp 
    850                 855                 860                 


Leu Arg Ser Ala Pro Asp Glu Pro Arg Thr Val Leu Glu Met Val His 
865                 870                 875                 880 


Leu Glu Val Ala Ser Ile Leu Gly Ile Thr Asp Pro Asp Ala Val Gln 
                885                 890                 895     


Asp Asp Ser Ser Phe Leu Glu Leu Gly Phe Asp Ser Leu Ser Gly Val 
            900                 905                 910         


Arg Leu Arg Asn Arg Leu Thr Gln Val Thr Gly Leu Thr Leu Pro Ala 
        915                 920                 925             


Thr Leu Leu Phe Asp His Asp Thr Pro Ser Ala Leu Ala Thr Glu Leu 
    930                 935                 940                 


Asp 
945 


<210>  20
<211>  907
<212>  PRT
<213>  Streptomyces kanamyceticus

<400>  20

Glu Pro Leu Ala Val Val Gly Met Ala Cys Arg Leu Pro Gly Gly Ile 
1               5                   10                  15      


Thr Ser Pro Glu Glu Leu Trp Glu Leu Val Glu Asp Gly Gly Asp Ala 
            20                  25                  30          


Val Gly Asp Phe Pro Thr Asp Arg Gly Trp Asp Val Ala Ala Leu His 
        35                  40                  45              


Ala Ala Ala Glu Ser Ala Thr Ser Arg Ala Gly Ala Leu Met Gly Ala 
    50                  55                  60                  


Ala Asp Phe Asp Ala Ala Phe Phe Gly Ile Ser Pro Arg Glu Ala Thr 
65                  70                  75                  80  


Ala Leu Asp Pro Gln Gln Arg Ile Leu Leu Glu Ile Ala Trp Glu Ala 
                85                  90                  95      


Ile Glu Arg Ala Gly Ile Lys Ala Asp Val Leu Arg Gly Thr Asp Thr 
            100                 105                 110         


Gly Val Phe Val Gly Gly Phe Tyr Tyr Gly Tyr Gly Ala Gly Ala Asp 
        115                 120                 125             


Leu Gly Gly Phe Gly Ala Tyr Ser Thr Gln Pro Ala Val Leu Ala Gly 
    130                 135                 140                 


Arg Leu Ser Tyr Phe Phe Gly Leu Glu Gly Pro Ala Val Thr Val Asp 
145                 150                 155                 160 


Thr Ala Cys Ser Ser Ser Leu Val Ala Leu His Gln Ala Gly Gln Ala 
                165                 170                 175     


Leu Arg Ala Gly Glu Cys Ser Leu Ala Leu Val Gly Gly Val Thr Val 
            180                 185                 190         


Met Ala Ser Pro Gln Ser Phe Val Glu Phe Ser Arg Gln Gly Gly Val 
        195                 200                 205             


Ala Pro Asp Gly Arg Cys Lys Ala Phe Ala Asp Ala Ala Asp Gly Thr 
    210                 215                 220                 


Gly Phe Ala Glu Gly Ala Gly Val Leu Val Val Glu Arg Leu Ser Asp 
225                 230                 235                 240 


Ala Glu Arg Asn Gly His Thr Val Leu Ala Val Val Arg Gly Ser Ala 
                245                 250                 255     


Val Asn Gln Asp Gly Ala Ser Asn Gly Ile Ser Ala Pro Asn Gly Pro 
            260                 265                 270         


Ala Gln Gln Arg Val Ile Arg Gln Ala Leu Gly Ser Ala Gly Leu Ala 
        275                 280                 285             


Pro Ala Asp Val Asp Val Val Glu Ala His Gly Thr Gly Thr Val Leu 
    290                 295                 300                 


Gly Asp Pro Ile Glu Ala Gln Ala Val Leu Ala Thr Tyr Gly Gln Gly 
305                 310                 315                 320 


Arg Glu Val Pro Leu Leu Leu Gly Ser Leu Lys Ser Asn Ile Gly His 
                325                 330                 335     


Ala Gln Ala Ala Ala Gly Val Ala Gly Val Ile Lys Met Val Met Ala 
            340                 345                 350         


Met Arg Arg Gly Val Val Pro Arg Thr Leu His Val Asp Glu Pro Ser 
        355                 360                 365             


Ser His Val Asp Trp Thr Thr Gly Ala Val Glu Leu Leu Thr Glu Ala 
    370                 375                 380                 


Arg Pro Trp Pro Glu Ser Asp Arg Pro Arg Arg Ala Gly Val Ser Ala 
385                 390                 395                 400 


Phe Gly Val Ser Gly Thr Asn Ala His Val Ile Leu Glu Glu Val Ala 
                405                 410                 415     


Glu Ser Ser Val Arg Ser Gly Gly Ser Ser Gly Leu Val Pro Leu Pro 
            420                 425                 430         


Val Ser Ala Arg Thr Glu Ser Ser Leu Ala Val Gln Val Glu Arg Leu 
        435                 440                 445             


Gly Ala Tyr Val Arg Ser Gly Ala Asp Leu Ser Ala Val Ala Asp Gly 
    450                 455                 460                 


Leu Val Arg Glu Arg Val Val Phe Gly His Arg Ala Val Leu Leu Gly 
465                 470                 475                 480 


Glu Ser Thr Val Ala Gly Val Ala Glu Gly Glu Leu Arg Thr Val Phe 
                485                 490                 495     


Val Phe Pro Gly Gln Gly Ser Gln Trp Val Gly Met Gly Arg Glu Leu 
            500                 505                 510         


Met Gly Ala Ser Glu Val Phe Ala Ala Arg Met Arg Glu Cys Ala Ala 
        515                 520                 525             


Ala Leu Glu Pro His Thr Gly Trp Asp Leu Leu Asp Val Leu Gly Glu 
    530                 535                 540                 


Ala Val Val Ala Asp Arg Val Glu Val Leu Gln Pro Ala Ser Trp Ala 
545                 550                 555                 560 


Val Ala Val Ser Leu Ala Ala Leu Trp Gln Ala His Gly Gly Thr Pro 
                565                 570                 575     


Asp Ala Val Ile Gly His Ser Gln Gly Glu Ile Ala Ala Ala Ser Val 
            580                 585                 590         


Ala Gly Ala Leu Ser Leu Glu Asp Ala Ala Arg Ile Val Ala Leu Arg 
        595                 600                 605             


Ser Gln Thr Ile Ala Ala Arg Leu Gly Arg Gly Ala Met Ala Ser Ile 
    610                 615                 620                 


Ala Ile Pro Ser Ala Glu Val Glu Val Met Glu Gly Val Trp Val Ala 
625                 630                 635                 640 


Ala Arg Asn Gly Pro Ser Ser Thr Val Ile Ala Gly Asp Pro Ala Ala 
                645                 650                 655     


Val Glu Gln Val Leu Ala Arg Tyr Glu Ala Glu Gly Val Arg Val Arg 
            660                 665                 670         


Arg Ile Ala Val Asp Tyr Ala Ser His Thr Pro His Val Glu Ala Ile 
        675                 680                 685             


Gln Asp Glu Leu Ala Glu Val Leu Glu Gly Val Thr Ala Gln Val Pro 
    690                 695                 700                 


Thr Ile Pro Trp Trp Ser Thr Val Asp Ser Asp Trp Val Thr Glu Pro 
705                 710                 715                 720 


Val Asp Asp Asp Tyr Trp Tyr Arg Asn Leu Arg Gln Pro Val Ala Met 
                725                 730                 735     


Asp Thr Ala Ile Gly Glu Leu Asp Gly Ser Leu Phe Ile Glu Cys Ser 
            740                 745                 750         


Ala His Pro Val Leu Leu Pro Ala Leu Asp Gln Glu Arg Thr Val Ala 
        755                 760                 765             


Ser Leu Arg Thr Asp Asp Gly Gly Trp Glu Arg Phe Leu Thr Ala Leu 
    770                 775                 780                 


Ala Glu Ala Trp Thr Gln Gly Ala Asp Val Asp Trp Thr Ile Leu Val 
785                 790                 795                 800 


Glu Pro Ala Pro His Arg Leu Asp Leu Pro Thr Tyr Pro Phe Asp His 
                805                 810                 815     


Lys Arg Tyr Trp Leu Leu Glu Arg Leu Gly Ala Met Thr Gly Ala Asp 
            820                 825                 830         


Arg Asp Ala Ala Leu Leu Thr Leu Val Arg Asp Cys Ala Ala Ala Val 
        835                 840                 845             


Leu Gly His Val Asp Ala Ala Gly Val Pro Ala Asp Ala Ala Phe Lys 
    850                 855                 860                 


Asp Leu Gly Val Asp Ser Leu Thr Ala Val Glu Leu Arg Asn Arg Leu 
865                 870                 875                 880 


Ala Ala Ala Thr Gly Val Arg Leu Pro Ala Thr Leu Ala Phe Asp His 
                885                 890                 895     


Pro Thr Pro Arg Ala Ile Ala Ser Arg Leu Asp 
            900                 905         


<210>  21
<211>  905
<212>  PRT
<213>  Streptomyces kanamyceticus

<400>  21

Glu Pro Leu Ala Ile Val Gly Met Ala Cys Arg Leu Pro Gly Gly Val 
1               5                   10                  15      


Ala Ser Pro Gly Asp Leu Trp Gln Met Leu Asp Ser Gly Gly Asp Ala 
            20                  25                  30          


Val Thr Gly Phe Pro Val Asp Arg Gly Trp Asp Pro Ser Gly Leu Thr 
        35                  40                  45              


Gly Gly Pro Asp Ala Asp Arg Gly Gly Phe Leu Ser Asp Ala Ala Asp 
    50                  55                  60                  


Phe Asp Ala Ala Phe Phe Gly Ile Ser Pro Arg Glu Ala Leu Ala Met 
65                  70                  75                  80  


Asp Pro Gln Gln Arg Ile Leu Leu Glu Thr Thr Trp Glu Ala Phe Glu 
                85                  90                  95      


Asn Ala Gly Ile Val Pro Gly Thr Leu Arg Gly Ser Asp Thr Gly Val 
            100                 105                 110         


Phe Met Gly Ala Phe Ser Tyr Gly Tyr Gly Val Gly Ala Asp Leu Gly 
        115                 120                 125             


Gly Phe Gly Ser Ile Gly Val Gln Pro Ser Val Leu Thr Gly Arg Ile 
    130                 135                 140                 


Ser Tyr Phe Tyr Gly Leu Gln Gly Pro Ala Phe Thr Val Asp Thr Ala 
145                 150                 155                 160 


Cys Ser Ser Ser Leu Val Ala Leu His Gln Ala Gly His Ala Leu Arg 
                165                 170                 175     


His Gly Glu Cys Ser Leu Ala Leu Val Gly Gly Val Thr Val Met Ala 
            180                 185                 190         


Asn Pro Asp Gly Phe Val Glu Phe Glu Gln Gln Gly Gly Leu Ser Pro 
        195                 200                 205             


Asp Gly Arg Cys Arg Ala Phe Ala Asp Ala Ala Asn Gly Thr Gly Trp 
    210                 215                 220                 


Ala Glu Gly Ala Gly Val Leu Val Val Glu Arg Leu Ser Asp Ala Glu 
225                 230                 235                 240 


Arg Asn Gly His Thr Val Leu Ala Val Val Arg Gly Ser Ala Val Asn 
                245                 250                 255     


Gln Asp Gly Ala Ser Asn Gly Leu Ser Ala Pro Asn Gly Pro Ser Gln 
            260                 265                 270         


Gln Arg Val Ile Arg Gln Ala Leu Ala Asn Ala Gly Leu Gly Ala Ala 
        275                 280                 285             


Asp Val Asp Val Val Glu Ala His Gly Thr Gly Thr Val Leu Gly Asp 
    290                 295                 300                 


Pro Ile Glu Ala Gln Ala Val Leu Ala Thr Tyr Gly Gln Gly Arg Glu 
305                 310                 315                 320 


Val Pro Leu Leu Leu Gly Ser Leu Lys Ser Asn Ile Gly His Ala Gln 
                325                 330                 335     


Ala Ala Ala Gly Val Ala Gly Val Ile Lys Met Val Met Ala Met Arg 
            340                 345                 350         


Arg Gly Val Val Pro Arg Thr Leu His Val Asp Glu Pro Ser Ser His 
        355                 360                 365             


Val Asp Trp Thr Ala Gly Ala Val Glu Val Val Thr Glu Ala Arg Pro 
    370                 375                 380                 


Trp Pro Glu Ser Gly Arg Val Pro Arg Ala Gly Val Ser Ser Phe Gly 
385                 390                 395                 400 


Val Ser Gly Thr Asn Ala His Val Val Leu Glu Gly Ala Pro Glu Pro 
                405                 410                 415     


Ser Ser Gly Ala Glu Ala Ser Ser Gly Gly Gly Leu Val Pro Leu Pro 
            420                 425                 430         


Val Ser Ala Arg Thr Glu Ser Ser Leu Ala Val Gln Val Glu Arg Leu 
        435                 440                 445             


Gly Ala Tyr Val Arg Gly Gly Ala Asp Leu Gly Ala Val Ala Asp Gly 
    450                 455                 460                 


Leu Val Arg Gly Arg Ala Val Phe Asp Arg Arg Ala Val Leu Leu Gly 
465                 470                 475                 480 


Glu Ser Thr Val Ala Gly Val Ala Val Glu Gly Ala Arg Thr Val Phe 
                485                 490                 495     


Val Phe Pro Gly Gln Gly Ser Gln Trp Val Gly Met Gly Arg Glu Leu 
            500                 505                 510         


Met Gly Val Ser Glu Val Phe Ala Ala Arg Met Arg Glu Cys Ala Ala 
        515                 520                 525             


Ala Leu Glu Pro Tyr Thr Gly Trp Asp Val Leu Asp Val Leu Gly Glu 
    530                 535                 540                 


Ala Val Val Ala Asp Arg Val Glu Val Leu Gln Pro Ala Ser Trp Ala 
545                 550                 555                 560 


Val Ala Val Ser Leu Ala Ala Leu Trp Gln Ala His Gly Val Val Pro 
                565                 570                 575     


Asp Ala Val Val Gly His Ser Gln Gly Glu Ile Ala Ala Ala Cys Val 
            580                 585                 590         


Ala Gly Ala Leu Ser Leu Glu Asp Ala Ala Arg Val Val Ala Leu Arg 
        595                 600                 605             


Ser Gln Thr Ile Ala Ala Arg Leu Gly His Gly Ala Met Ala Ser Ile 
    610                 615                 620                 


Ala Leu Pro Ala Ser Ala Val Glu Val Met Glu Gly Val Trp Ile Ala 
625                 630                 635                 640 


Ala Arg Asn Gly Pro Glu Ser Thr Val Val Ala Gly Asp Pro Ala Ala 
                645                 650                 655     


Val Glu Arg Val Leu Ala Arg Tyr Glu Ala Ala Gly Val Arg Val Arg 
            660                 665                 670         


Arg Ile Ala Val Asp Tyr Ala Ser His Thr Pro His Val Glu Ala Ile 
        675                 680                 685             


Gln Asp Glu Leu Ala Asp Val Leu Gly Gly Ile Thr Ser Ser Ala Pro 
    690                 695                 700                 


Asp Ile Ser Trp Trp Ser Thr Val Asp Ser Gly Trp Val Thr Glu Ala 
705                 710                 715                 720 


Val Gly Asp Asp Tyr Trp Tyr Arg Asn Leu Arg Gln Pro Val Ala Met 
                725                 730                 735     


Asp Thr Ala Val Ser Glu Leu Asp Gly Ser Leu Phe Ile Glu Cys Ser 
            740                 745                 750         


Ala His Pro Val Leu Leu Pro Ala Leu Asp Gln Glu Arg Thr Val Ala 
        755                 760                 765             


Ser Leu Arg Thr Asp Asp Gly Gly Trp Asp Arg Phe Leu Thr Ala Leu 
    770                 775                 780                 


Ala Gln Ala Trp Thr Gln Gly Ala Asp Val Asp Trp Thr Thr Leu Ile 
785                 790                 795                 800 


Glu Pro Ala Gln His Arg Leu Asp Leu Pro Thr Tyr Pro Phe Asp His 
                805                 810                 815     


Lys Arg Tyr Trp Leu Gln Pro Ala Gly Ala Arg Asn Glu Val Ala Arg 
            820                 825                 830         


His Thr Asp Leu Leu Thr Leu Val Arg Gln Lys Ala Ala Ala Leu Leu 
        835                 840                 845             


Gly His Ala Gly Pro Glu Asp Val Pro Glu Asp Ala Ala Phe Arg Gln 
    850                 855                 860                 


Leu Gly Val Asp Ser Leu Ile Ala Val Gln Leu Arg Asn Gly Leu Asn 
865                 870                 875                 880 


Glu Ala Thr Gly Leu Arg Leu Ser Ala Thr Leu Val Phe Asp Tyr Pro 
                885                 890                 895     


Thr Pro Arg Ala Leu Ala Gly Arg Ile 
            900                 905 


<210>  22
<211>  913
<212>  PRT
<213>  Streptomyces kanamyceticus

<400>  22

Glu Pro Val Ala Ile Val Gly Met Ala Cys Arg Leu Pro Gly Gly Val 
1               5                   10                  15      


Thr Ser Pro Glu Asp Leu Trp Arg Leu Val Ala Ser Gly Thr Asp Ala 
            20                  25                  30          


Ile Thr Glu Phe Pro Ala Asp Arg Gly Trp Asp Val Asp Ala Leu Phe 
        35                  40                  45              


Asp Pro Asp Pro Asp Ala Val Gly Arg Ser Thr Thr Arg His Gly Gly 
    50                  55                  60                  


Phe Leu Thr Glu Ala Thr Gly Phe Asp Ala Ala Phe Phe Gly Ile Ser 
65                  70                  75                  80  


Pro Asn Glu Ala Leu Ala Met Asp Pro Gln Gln Arg Leu Val Leu Glu 
                85                  90                  95      


Thr Ser Trp Glu Ala Phe Glu His Ala Gly Ile Val Pro Asp Thr Leu 
            100                 105                 110         


Arg Glu Ser Asp Thr Gly Val Phe Met Gly Ala Phe His Gln Gly Tyr 
        115                 120                 125             


Gly Ala Gly Arg Asp Leu Gly Gly Leu Gly Val Thr Ala Thr Gln Thr 
    130                 135                 140                 


Ser Val Leu Ser Gly Arg Leu Ser Tyr Phe Tyr Gly Leu Gln Gly Pro 
145                 150                 155                 160 


Ala Val Thr Val Asp Thr Ala Cys Ser Ser Ser Leu Val Ala Leu His 
                165                 170                 175     


Gln Ala Ala Gln Ala Leu Arg Ser Gly Glu Cys Ser Leu Ala Leu Ala 
            180                 185                 190         


Gly Gly Val Thr Val Met Ala Thr Pro Gly Ser Phe Val Glu Phe Ser 
        195                 200                 205             


Arg Gln Arg Gly Leu Ser Pro Asp Gly Arg Cys Lys Ala Phe Ala Asp 
    210                 215                 220                 


Ser Ala Asp Gly Thr Gly Phe Ala Glu Gly Val Gly Val Leu Val Val 
225                 230                 235                 240 


Glu Arg Leu Ser Asp Ala Glu Arg Asn Gly His Thr Val Leu Ala Val 
                245                 250                 255     


Val Arg Gly Ser Ala Val Asn Gln Asp Gly Ala Ser Asn Gly Leu Ser 
            260                 265                 270         


Ala Pro Asn Gly Val Ala Gln Gln Arg Val Ile Arg Gln Ala Leu Ala 
        275                 280                 285             


Asn Ala Gly Leu Asn Gly Thr Asp Val Asp Ala Val Glu Ala His Gly 
    290                 295                 300                 


Thr Gly Thr Val Leu Gly Asp Pro Ile Glu Ala Gln Ala Val Leu Ala 
305                 310                 315                 320 


Thr Tyr Gly Gln Glu Arg Glu Val Pro Leu Leu Leu Gly Ser Val Lys 
                325                 330                 335     


Ser Asn Val Gly His Thr Gln Ala Ala Ala Gly Val Ala Gly Val Ile 
            340                 345                 350         


Lys Met Val Met Ala Met Arg Arg Gly Val Val Pro Arg Thr Leu His 
        355                 360                 365             


Val Asp Glu Ser Ser Ser His Val Asp Trp Ser Ala Gly Ala Val Glu 
    370                 375                 380                 


Val Val Thr Glu Ala Arg Pro Trp Pro Glu Ser Gly Gly Ala Arg Arg 
385                 390                 395                 400 


Ala Gly Val Ser Ser Phe Gly Val Ser Gly Thr Asn Ala His Val Ile 
                405                 410                 415     


Leu Glu Gly Val Ala Glu Ser Ser Val Arg Ser Gly Gly Ser Ser Ala 
            420                 425                 430         


Gly Leu Val Pro Leu Pro Val Ser Ala Arg Thr Glu Ser Ser Leu Ala 
        435                 440                 445             


Leu Gln Val Glu Arg Leu Gly Glu Tyr Val Arg Gly Gly Ala Asp Leu 
    450                 455                 460                 


Gly Ala Val Ala Asp Gly Leu Val Arg Gly Arg Ala Val Phe Gly Arg 
465                 470                 475                 480 


Arg Ala Val Leu Leu Gly Glu Ser Thr Val Ala Gly Val Ala Val Glu 
                485                 490                 495     


Gly Ala Arg Thr Val Phe Val Phe Pro Gly Gln Gly Ser Gln Trp Val 
            500                 505                 510         


Gly Met Gly Arg Glu Leu Met Gly Val Ser Glu Val Phe Ala Ala Arg 
        515                 520                 525             


Met Arg Glu Cys Ala Ala Ala Leu Glu Pro His Thr Gly Trp Asp Val 
    530                 535                 540                 


Leu Asp Val Leu Gly Glu Ala Val Val Ala Asp Arg Val Glu Val Leu 
545                 550                 555                 560 


Gln Pro Ala Ser Trp Ala Val Ala Val Ser Leu Ala Ala Leu Trp Gln 
                565                 570                 575     


Ala His Gly Val Val Pro Asp Ala Val Val Gly His Ser Gln Gly Glu 
            580                 585                 590         


Ile Ala Ala Ala Cys Val Ala Gly Ala Leu Ser Leu Glu Asp Ala Ala 
        595                 600                 605             


Arg Val Val Ala Leu Arg Ser Gln Thr Ile Ala Ala Arg Leu Gly His 
    610                 615                 620                 


Gly Ala Met Ala Ser Ile Ala Leu Pro Ala Ser Ala Val Glu Val Met 
625                 630                 635                 640 


Glu Gly Val Trp Ile Ala Ala Arg Asn Gly Pro Glu Ser Thr Val Val 
                645                 650                 655     


Ala Gly Asp Pro Ala Ala Val Glu Arg Val Leu Ala Arg Tyr Glu Ala 
            660                 665                 670         


Ala Gly Val Arg Val Arg Arg Ile Ala Val Asp Tyr Ala Ser His Thr 
        675                 680                 685             


Pro His Val Glu Ala Ile Gln Asp Glu Leu Ala Asp Val Leu Gly Gly 
    690                 695                 700                 


Ile Thr Ser Ser Ala Pro Ser Val Pro Trp Trp Ser Thr Val Asp Ser 
705                 710                 715                 720 


Gly Trp Val Thr Glu Pro Val Asp Asp Asp Tyr Trp Tyr Arg Asn Leu 
                725                 730                 735     


Arg Gln Pro Val Ala Met Asp Thr Ala Thr Gly Glu Leu Asp Gly Ser 
            740                 745                 750         


Leu Phe Ile Glu Cys Ser Ala His Pro Val Leu Leu Pro Ala Leu Asp 
        755                 760                 765             


Gln Glu Arg Thr Val Ala Ser Leu Arg Thr Asp Asp Gly Gly Trp Glu 
    770                 775                 780                 


Arg Phe Leu Thr Ala Leu Ala Glu Ala Trp Thr Gln Gly Ala Asp Val 
785                 790                 795                 800 


Asp Trp Thr Thr Leu Ile Glu Pro Ala Gln His Arg Val Asp Leu Pro 
                805                 810                 815     


Thr Tyr Pro Phe Asp His Lys Arg Tyr Trp Leu Gln Pro Ala Arg Arg 
            820                 825                 830         


Thr Val Arg Thr Gly Glu Asp Ser Gly Arg Asp Leu Leu Ala Val Val 
        835                 840                 845             


Cys Gly Ala Thr Ala Ala Val Leu Gly His Ala Asp Ala Ser Glu Ile 
    850                 855                 860                 


Gly Pro Ala Thr Ala Phe Lys Asp Leu Gly Ile Asp Ser Leu Ser Gly 
865                 870                 875                 880 


Ile Arg Leu Arg Asn Ser Leu Ala Glu Thr Thr Gly Val Arg Leu Ser 
                885                 890                 895     


Ala Thr Ala Val Phe Asp His Pro Thr Pro Asp Ala Leu Ala Ala Arg 
            900                 905                 910         


Leu 
    


<210>  23
<211>  928
<212>  PRT
<213>  Streptomyces kanamyceticus

<400>  23

Glu Pro Leu Ala Ile Val Ala Met Ala Cys Arg Met Pro Gly Gly Val 
1               5                   10                  15      


Asp Thr Pro Glu Asp Leu Trp Arg Leu Val Glu Ser Gly Gly Asp Ala 
            20                  25                  30          


Ile Thr Glu Phe Pro Thr Asp Arg Gly Trp Asp Leu Ala Ala Leu Tyr 
        35                  40                  45              


Asp Pro Asp Pro Asp Ala Ile Gly Lys Val Ser Val Arg His Gly Gly 
    50                  55                  60                  


Phe Leu Ala Gly Ala Ala Asp Phe Asp Ala Glu Phe Phe Gly Ile Ser 
65                  70                  75                  80  


Pro Arg Glu Ala Leu Ala Met Asp Pro Gln Gln Arg Leu Ile Leu Glu 
                85                  90                  95      


Val Ser Trp Glu Ala Phe Glu Arg Ala Gly Ile Leu Pro Ala Ser Val 
            100                 105                 110         


Arg Gly Ser Asp Ala Gly Val Phe Met Gly Ala Phe Thr Gln Gly Tyr 
        115                 120                 125             


Gly Ala Gly Val Asp Leu Gly Gly Phe Gly Ala Thr Gly Thr Pro Thr 
    130                 135                 140                 


Ser Val Leu Ser Gly Arg Leu Ser Tyr Tyr Phe Gly Leu Glu Gly Pro 
145                 150                 155                 160 


Ser Val Thr Val Asp Thr Ala Cys Ser Ser Ser Leu Val Ala Leu His 
                165                 170                 175     


Gln Ala Ala Arg Ser Leu Arg Ser Gly Glu Cys Ser Leu Ala Leu Val 
            180                 185                 190         


Gly Gly Val Thr Val Met Ala Thr Thr Thr Gly Phe Val Glu Phe Ser 
        195                 200                 205             


Arg Gln Arg Gly Leu Ala Pro Asp Gly Arg Ala Lys Ala Phe Ala Asp 
    210                 215                 220                 


Thr Ala Asp Gly Thr Ser Phe Ala Glu Gly Ala Gly Val Leu Ile Val 
225                 230                 235                 240 


Glu Arg Leu Ser Asp Ala Thr Arg Leu Gly His Pro Val Leu Ala Val 
                245                 250                 255     


Val Arg Gly Ser Ala Val Asn Ser Asp Gly Ala Ser Asn Gly Leu Ser 
            260                 265                 270         


Ala Pro Asn Gly Pro Ala Gln Arg Arg Val Ile Glu Arg Ala Leu Asp 
        275                 280                 285             


Asp Ala Gly Leu Val Pro Gly Asp Ile Asp Ala Val Glu Ala His Gly 
    290                 295                 300                 


Thr Gly Thr Arg Leu Gly Asp Pro Ile Glu Ala Gln Ala Leu Glu Ala 
305                 310                 315                 320 


Ala Tyr Gly Leu Asp Arg Val His Pro Leu Leu Ile Gly Ser Leu Lys 
                325                 330                 335     


Ser Asn Leu Gly His Thr Gln Ala Ala Ala Gly Val Ala Gly Val Ile 
            340                 345                 350         


Lys Met Val Leu Ala Met Arg His Gly Val Leu Pro Arg Thr Leu His 
        355                 360                 365             


Val Asp Glu Pro Ser Arg His Val Asp Trp Gly Gly Gly Val Arg Leu 
    370                 375                 380                 


Leu Arg Arg Asn Glu Pro Trp Pro Val Thr Gly Arg Val Arg Arg Ala 
385                 390                 395                 400 


Gly Val Ser Ser Phe Gly Ile Ser Gly Ala Asn Ala His Val Val Ile 
                405                 410                 415     


Glu Ala Gly Pro Pro Ala Ala Pro Ala Thr Leu Pro Ala Thr Glu Pro 
            420                 425                 430         


Val Pro Glu Gly Val Val Trp Pro Val Ser Ala Arg Thr Pro Asp Gly 
        435                 440                 445             


Val Arg Asp Val Ala Gly Arg Leu Val Ala Leu Thr Ala Pro Ala Ala 
    450                 455                 460                 


Ala Ile Gly His Ser Leu Ala Thr Thr Arg Thr Ala Met Arg His Arg 
465                 470                 475                 480 


Ala Val Val Pro Ala Arg Asp Ala Glu Ala Phe Ala Arg Gly Glu Glu 
                485                 490                 495     


Val Pro Gly Val Val Arg Gly Thr Ala Asp Val Thr Asp Ala Arg Ala 
            500                 505                 510         


Val Phe Val Phe Pro Gly Gln Gly Ser Gln Trp Asp Gly Met Gly Ala 
        515                 520                 525             


Glu Leu Leu Ala Thr Glu Pro Val Phe Ala Arg Arg Leu Gly Glu Cys 
    530                 535                 540                 


Ala Glu Ala Leu Ala Pro Tyr Thr Gly Trp Asp Leu Leu Asp Val Ile 
545                 550                 555                 560 


Ala Arg Arg Pro Gly Ala Pro Ala Leu Asp Arg Val Asp Val Val Gln 
                565                 570                 575     


Pro Val Ser Phe Ala Met Met Val Ala Leu Ala Glu Leu Trp Arg Ser 
            580                 585                 590         


Arg Gly Val Ala Pro Ala Ala Val Val Gly His Ser Gln Gly Glu Val 
        595                 600                 605             


Ala Ala Ala Cys Val Ala Gly Val Leu Thr Leu Asp Asp Ala Ala Lys 
    610                 615                 620                 


Val Val Ala Leu Arg Ser Arg Leu Val Ala Thr Glu Leu Gly His Gly 
625                 630                 635                 640 


Gly Met Val Ser Val Pro Pro Ala Asp Phe Asp Ala Ala Ala Trp Ala 
                645                 650                 655     


Gly Arg Leu Glu Val Ala Ala Val Asn Gly Pro Ala Ser Ile Val Val 
            660                 665                 670         


Ala Gly Ala Ala Asp Ala Val Glu Glu Leu Leu Ala Ala Thr Pro His 
        675                 680                 685             


Ala Arg Arg Ile Ala Val Asp Tyr Ala Ser His Thr Ala His Val Glu 
    690                 695                 700                 


Thr Ile Arg Asp Ala Leu Leu Asp Ala Leu Ala Asp Leu Thr Pro Gly 
705                 710                 715                 720 


Ala Pro Glu Val Pro Phe Phe Ser Thr Val Asp Glu Ala Trp Leu Asp 
                725                 730                 735     


Arg Pro Ala Asp Ala Ala Tyr Trp Tyr Asp Asn Val Arg Arg Pro Val 
            740                 745                 750         


Arg Phe Gly Ala Ala Thr Ala Arg Leu Ala Glu Leu Gly Tyr Arg Val 
        755                 760                 765             


Phe Val Glu Ala Ser Pro His Pro Val Leu Thr Thr Ala Leu Ala Asp 
    770                 775                 780                 


Thr Leu Ala Gly His Pro Asn Thr Ala Val Thr Gly Thr Leu Arg Arg 
785                 790                 795                 800 


Gly Asp Gly Gly Ala Arg Arg Phe Thr Ser Ser Leu Ala Glu Leu Trp 
                805                 810                 815     


Val Arg Gly Val Pro Val Ser Trp Pro Ser Gly Glu Ser Arg Arg Val 
            820                 825                 830         


Pro Leu Pro Thr Tyr Pro Phe Arg Arg Asp Arg Tyr Trp Ile Asp Ala 
        835                 840                 845             


Glu Ala Ala Pro Thr Ala Ala Arg Asp Met Leu Glu Leu Val Arg Thr 
    850                 855                 860                 


Ser Ala Ala Leu Val Leu Gly His Arg Asp Ala His Ala Ile Glu Pro 
865                 870                 875                 880 


Thr Arg Ala Phe Lys Glu Val Gly Phe Asp Ser Leu Thr Gly Val Glu 
                885                 890                 895     


Leu Arg Asn Arg Leu Ala Asp Ala Thr Gly Leu Thr Leu Pro Ala Thr 
            900                 905                 910         


Leu Val Phe Asp His Pro Thr Ala Gln Ala Leu Ala Ala His Leu Asp 
        915                 920                 925             


<210>  24
<211>  893
<212>  PRT
<213>  Streptomyces kanamyceticus

<400>  24

Glu Pro Leu Ala Ile Val Gly Met Ala Cys Arg Leu Pro Gly Gly Val 
1               5                   10                  15      


Ala Ser Pro Glu Asp Leu Trp Arg Leu Leu Glu Ser Gly Gly Asp Gly 
            20                  25                  30          


Ile Thr Thr Phe Pro Gly Asp Arg Gly Trp Asp Val Glu Ala Leu Tyr 
        35                  40                  45              


Asp Pro Asp Pro Glu His Pro Gly Thr Ser Thr Val Arg His Gly Gly 
    50                  55                  60                  


Phe Leu Ser Gly Ala Gly Asp Phe Asp Ala Gly Phe Phe Gly Ile Ser 
65                  70                  75                  80  


Pro Arg Glu Ala Val Ala Met Asp Pro Gln Gln Arg Val Val Met Glu 
                85                  90                  95      


Thr Ser Trp Glu Ala Leu Glu Tyr Ala Gly Ile Asp Pro His Thr Leu 
            100                 105                 110         


Arg Gly Ser Asp Thr Gly Val Phe Met Gly Gly Tyr Phe Tyr Gly Tyr 
        115                 120                 125             


Gly Ser Gly Ala Asp Arg Gly Gly Phe Gly Ala Thr Ser Thr Gln Thr 
    130                 135                 140                 


Ser Val Leu Ser Gly Arg Leu Ser Tyr Phe Tyr Gly Leu Glu Gly Pro 
145                 150                 155                 160 


Ala Val Thr Val Asp Thr Ala Cys Ser Ser Ser Leu Val Ala Leu His 
                165                 170                 175     


Gln Ala Gly Gln Ser Leu Arg Thr Gly Glu Cys Ser Leu Ala Leu Val 
            180                 185                 190         


Gly Gly Val Thr Val Met Ala Ser Pro Ser Gly Phe Val Asp Phe Ser 
        195                 200                 205             


Gln Gln Arg Gly Leu Ala Pro Asp Gly Arg Cys Lys Ala Phe Ala Glu 
    210                 215                 220                 


Ala Ala Asp Gly Thr Gly Phe Ala Glu Gly Ser Gly Val Leu Val Val 
225                 230                 235                 240 


Glu Arg Leu Ser Asp Ala Glu Arg His Gly His Arg Val Leu Ala Val 
                245                 250                 255     


Val Arg Gly Ser Ala Val Asn Gln Asp Gly Ala Ser Asn Gly Leu Ser 
            260                 265                 270         


Ala Pro Asn Gly Pro Ser Gln Glu Arg Val Ile Arg Gln Ala Leu Ala 
        275                 280                 285             


Asn Ala Gly Leu Gln Pro Ser Asp Val Asp Ala Val Glu Ala His Gly 
    290                 295                 300                 


Thr Gly Thr Arg Leu Gly Asp Pro Ile Glu Ala Thr Ala Leu Leu Ala 
305                 310                 315                 320 


Thr Tyr Gly Gln Asp Arg Ala Thr Pro Leu Leu Leu Gly Ser Leu Lys 
                325                 330                 335     


Ser Asn Ile Gly His Thr Gln Ala Ala Ala Gly Val Ala Gly Ile Ile 
            340                 345                 350         


Lys Met Val Leu Ala Met His His Asp Thr Leu Pro Ser Thr Leu His 
        355                 360                 365             


Val Asp Thr Pro Ser Ser His Val Asp Trp Thr Ala Gly Thr Val Glu 
    370                 375                 380                 


Leu Leu Thr Asp Ala Arg Pro Trp Pro Glu Thr Ser Arg Pro His Arg 
385                 390                 395                 400 


Ala Ala Val Ser Ser Phe Gly Val Ser Gly Thr Asn Ala His Val Ile 
                405                 410                 415     


Leu Glu Ser His Pro Arg Pro Thr Pro Ala Pro Asp Thr Gly Ser Ser 
            420                 425                 430         


Thr His Pro Val Pro Leu Leu Ile Ser Ala Arg Thr Pro Arg Ala Leu 
        435                 440                 445             


Ser Glu His Thr Thr Arg Val Ser Ala Phe Leu Asp Ala Gly Gly Gly 
    450                 455                 460                 


Asp Glu Arg Ala Val Ala Ser Ala Leu Leu Thr Arg Thr Ala Phe Thr 
465                 470                 475                 480 


His Arg Ala Ala Leu Ile Gly Thr Asp Leu Ile Thr Gly Thr Ala Val 
                485                 490                 495     


Pro Asp Arg Arg Leu Val Trp Leu Phe Ser Gly Gln Gly Ser Gln Arg 
            500                 505                 510         


Pro Gly Met Gly Asp Glu Leu Ala Ala Ala Tyr Asp Val Phe Ala Arg 
        515                 520                 525             


Thr Arg Arg Asp Val Leu Asp Ala Leu Gln Val Pro Ala Gly Leu Asp 
    530                 535                 540                 


Ile His Asp Thr Gly Tyr Ala Gln Pro Ala Val Phe Ala Leu Gln Val 
545                 550                 555                 560 


Ala Leu Ser Ala Gln Leu Asp Ala Trp Gly Val Arg Pro Asp Ala Leu 
                565                 570                 575     


Val Gly His Ser Ile Gly Glu Leu Ala Ala Ala Tyr Val Ala Gly Val 
            580                 585                 590         


Trp Ser Leu Asp Asp Ala Cys Ala Leu Val Ser Ala Arg Ala Arg Leu 
        595                 600                 605             


Met Gln Ala Leu Pro Pro Gly Gly Ala Met Ala Ala Val Ile Ala Ser 
    610                 615                 620                 


Glu Arg Asp Ala Leu Pro Leu Leu Arg Glu Gly Val Glu Ile Ala Ala 
625                 630                 635                 640 


Val Asn Gly Pro Ala Ser Ile Val Leu Ser Gly Asp Glu Asp Ala Val 
                645                 650                 655     


Leu Asp Val Ala Ala Arg Leu Gly Arg Phe Thr Arg Leu Arg Thr Ser 
            660                 665                 670         


His Ala Phe His Ser Ala Arg Met Glu Pro Met Leu Asp Glu Phe Arg 
        675                 680                 685             


Asp Val Ala Gln Arg Leu Thr Tyr His Glu Pro Lys Leu Pro Met Ala 
    690                 695                 700                 


Ala Gly Ala Asp Cys Ala Thr Pro Glu Tyr Trp Val Arg Gln Val Arg 
705                 710                 715                 720 


Asp Thr Val Arg Phe Gly Glu Gln Val Ala Ala Tyr Asp Gly Ala Ala 
                725                 730                 735     


Leu Leu Glu Ile Gly Pro Asp Arg Asn Leu Ala Arg Leu Val Asp Gly 
            740                 745                 750         


Ile Pro Val Leu His Gly Asp Asp Glu Ala Arg Ser Ala Met Thr Ala 
        755                 760                 765             


Leu Ala Arg Leu His Thr Gly Gly Val Ala Val Asp Trp Pro Glu Val 
    770                 775                 780                 


Ile Gly Ala Ala Pro Thr His Leu Asn Leu Pro Thr Tyr Pro Phe Glu 
785                 790                 795                 800 


Arg Thr Arg Tyr Trp Leu Gly Ser Arg Asp Arg Ile Ala Gly Leu Thr 
                805                 810                 815     


Ala Ala Asp Ala Glu Lys Ala Ala Leu Ala Val Val Arg Glu Cys Ala 
            820                 825                 830         


Ala Ala Val Leu Gly His Glu Gly Pro Ala Arg Ile Glu Ala Thr Ala 
        835                 840                 845             


Thr Phe Lys Glu Leu Gly Val Asp Ser Leu Thr Ala Val Arg Leu Arg 
    850                 855                 860                 


Asn Ala Phe Thr Glu Ala Thr Gly Val Arg Leu Pro Ala Thr Ala Val 
865                 870                 875                 880 


Phe Asp Phe Pro Thr Pro Gln Ala Val Ala Ala Lys Leu 
                885                 890             


<210>  25
<211>  930
<212>  PRT
<213>  Streptomyces kanamyceticus

<400>  25

Glu Pro Leu Ala Ile Val Gly Met Ala Cys Arg Leu Pro Gly Gly Val 
1               5                   10                  15      


Ala Ser Pro Glu Asp Leu Trp Arg Leu Leu Glu Ser Gly Gly Asp Gly 
            20                  25                  30          


Ile Thr Ala Phe Pro Ala Asp Arg Gly Trp Asp Val Glu Ala Leu Tyr 
        35                  40                  45              


Asp Pro Asp Pro Glu His Pro Gly Thr Ser Thr Val Arg His Gly Gly 
    50                  55                  60                  


Phe Leu Ser Gly Ala Gly Asp Phe Asp Ala Gly Phe Phe Gly Ile Ser 
65                  70                  75                  80  


Pro Arg Glu Ala Ile Ala Met Asp Pro Gln Gln Arg Val Val Leu Glu 
                85                  90                  95      


Thr Ser Trp Glu Ala Leu Glu Gln Ala Gly Ile Val Pro Gly Thr Leu 
            100                 105                 110         


Arg Gly Ser Asp Thr Gly Val Phe Met Gly Ala Phe Ser Asp Gly Tyr 
        115                 120                 125             


Gly Leu Gly Thr Asp Leu Gly Gly Phe Gly Ala Thr Gly Thr Gln Thr 
    130                 135                 140                 


Ser Val Leu Ser Gly Arg Leu Ser Tyr Phe Tyr Gly Leu Glu Gly Pro 
145                 150                 155                 160 


Ala Val Thr Val Asp Thr Ala Cys Ser Ser Ser Leu Val Ala Leu His 
                165                 170                 175     


Gln Ala Gly Gln Ser Leu Arg Thr Gly Glu Cys Ser Leu Ala Leu Val 
            180                 185                 190         


Gly Gly Val Thr Val Met Ala Ser Pro Gly Gly Phe Val Glu Phe Ser 
        195                 200                 205             


Gln Gln Arg Gly Leu Ala Pro Asp Gly Arg Cys Lys Ala Phe Ala Glu 
    210                 215                 220                 


Ala Ala Asp Gly Thr Ala Phe Ala Glu Gly Ser Gly Val Leu Val Val 
225                 230                 235                 240 


Glu Arg Leu Ser Asp Ala Glu Arg Arg Gly His Arg Ile Leu Ala Val 
                245                 250                 255     


Val Arg Gly Ser Ala Val Asn Gln Asp Gly Ala Ser Asn Gly Leu Ser 
            260                 265                 270         


Ala Pro Asn Gly Pro Ser Gln Glu Arg Val Ile Arg Gln Ala Leu Ala 
        275                 280                 285             


Asn Ala Gly Leu Arg Pro Ser Asp Val Asp Ala Val Glu Ala His Gly 
    290                 295                 300                 


Thr Gly Thr Arg Leu Gly Asp Pro Ile Glu Ala Thr Ala Leu Leu Ala 
305                 310                 315                 320 


Thr Tyr Gly Gln Asp Arg Ala Thr Pro Leu Leu Leu Gly Ser Leu Lys 
                325                 330                 335     


Ser Asn Ile Gly His Thr Gln Ala Ala Ala Gly Val Ala Gly Ile Ile 
            340                 345                 350         


Lys Met Val Leu Ala Met Arg His Gly Ser Leu Pro Arg Thr Leu Tyr 
        355                 360                 365             


Val Asp Thr Pro Ser Ser His Val Asp Trp Thr Ala Gly Gly Val Glu 
    370                 375                 380                 


Leu Leu Thr Asp Ala Arg Pro Trp Pro Ala Thr Thr Gly Pro Arg Arg 
385                 390                 395                 400 


Ala Ala Val Ser Ser Phe Gly Val Ser Gly Thr Asn Ala His Val Ile 
                405                 410                 415     


Leu Glu Ala His Ala Ala Pro Glu Pro Pro Ala Leu Asp Ser Pro Val 
            420                 425                 430         


Val Glu Pro Ser Ala Ser Leu Phe Ala Thr Glu Leu Thr Pro Leu Pro 
        435                 440                 445             


Val Ser Ala Arg Thr Ser Glu Ala Val Asp Gly Gln Val Gln Arg Leu 
    450                 455                 460                 


Arg Glu His Leu Ala Thr His Pro Gly Asp Asp Pro Arg Ala Val Ala 
465                 470                 475                 480 


Ala Ala Leu Leu Ala Thr Arg Thr Asp Phe Pro His Arg Ala Val Leu 
                485                 490                 495     


Leu Gly Asp Gly Val Val Thr Gly Thr Ala Leu Thr Ala Pro Arg Thr 
            500                 505                 510         


Val Phe Val Phe Pro Gly Gln Gly Ser Gln Trp Leu Gly Met Gly Arg 
        515                 520                 525             


Lys Leu Met Ala Glu Ser Pro Val Phe Ala Ala Arg Met Arg Gln Cys 
    530                 535                 540                 


Ala Asp Ala Leu Ala Glu His Thr Gly Arg Asp Leu Ile Ala Met Leu 
545                 550                 555                 560 


Asp Asp Pro Ala Val Lys Ser Arg Val Asp Val Val His Pro Val Cys 
                565                 570                 575     


Trp Ala Val Met Val Ser Leu Ala Ala Val Trp Glu Ala Ala Gly Val 
            580                 585                 590         


Arg Pro Asp Ala Val Ile Gly His Ser Gln Gly Glu Ile Ala Ala Ala 
        595                 600                 605             


Cys Val Ala Gly Ala Ile Ser Leu Glu Asp Gly Ala Arg Leu Val Ala 
    610                 615                 620                 


Leu Arg Ser Ala Leu Leu Val Glu Leu Ala Gly Arg Gly Ala Met Gly 
625                 630                 635                 640 


Ser Ile Ala Phe Ala Ala Ala Asp Val Glu Ala Ala Ala Ala Arg Ile 
                645                 650                 655     


Asp Gly Val Trp Val Ala Gly Arg Asn Gly Thr Ala Thr Thr Ile Val 
            660                 665                 670         


Ser Gly Arg Pro Asp Ala Val Glu Thr Leu Ile Ala Asp Tyr Glu Thr 
        675                 680                 685             


Arg Gly Val Trp Val Thr Arg Leu Val Val Asp Cys Pro Thr His Thr 
    690                 695                 700                 


Pro Phe Val Asp Pro Leu Tyr Asp Glu Leu Gln Arg Ile Val Ala Ala 
705                 710                 715                 720 


Thr Thr Ser Arg Ala Pro Glu Ile Pro Trp Phe Ser Thr Ala Asp Glu 
                725                 730                 735     


Arg Trp Ile Asp Ala Pro Leu Asp Asp Glu Tyr Trp Phe Arg Asn Met 
            740                 745                 750         


Arg Asn Pro Val Gly Phe Ala Ala Ala Val Ala Ala Ala Arg Glu Pro 
        755                 760                 765             


Gly Asp Thr Val Phe Ile Glu Val Ser Ala His Pro Val Leu Leu Pro 
    770                 775                 780                 


Ala Ile Asn Gly Thr Thr Val Gly Thr Leu Arg Arg Gly Gly Gly Ala 
785                 790                 795                 800 


Asp Arg Leu Leu Asp Ser Leu Ala Lys Ala His Thr Val Gly Val Ala 
                805                 810                 815     


Val Asp Trp Ala Ala His Asp Ala Ala Thr Gly Thr Ala Asp Leu Pro 
            820                 825                 830         


Thr Tyr Ala Phe His His Glu Arg Tyr Trp Ile Glu Pro Ala Glu Arg 
        835                 840                 845             


Leu Pro Asp Leu Ser Arg Lys Glu Gln Glu Gln Val Leu Leu Asp Val 
    850                 855                 860                 


Val Arg Asp Thr Ala Ala Thr Leu Leu Gly His Ala Asp Ala Arg Ala 
865                 870                 875                 880 


Val Thr Ala Thr Ala Ala Phe Lys Asp Leu Gly Val Asp Ser Leu Thr 
                885                 890                 895     


Ala Leu Gly Leu Arg Asp Arg Leu Ala Glu Ala Leu Gly Ile Pro Leu 
            900                 905                 910         


Pro Ala Thr Leu Val Phe Asp His Pro Ala Ala Gly Thr Leu Ser Arg 
        915                 920                 925             


His Leu 
    930 


<210>  26
<211>  870
<212>  PRT
<213>  Streptomyces kanamyceticus

<400>  26

Glu Pro Leu Ala Ile Val Gly Met Ala Cys Arg Leu Pro Gly Gly Val 
1               5                   10                  15      


Ala Ser Pro Asp Asp Leu Trp Arg Leu Leu Glu Ser Gly Gly Asp Gly 
            20                  25                  30          


Ile Gly Ala Phe Pro Gly Asp Arg Gly Trp Glu Thr Gly Ala Asp Gly 
        35                  40                  45              


Arg Gly Gly Phe Leu Ser Gly Ala Ala Gly Phe Asp Ala Ala Phe Phe 
    50                  55                  60                  


Gly Val Ser Pro Arg Glu Ala Leu Ala Met Asp Pro Gln Gln Arg Val 
65                  70                  75                  80  


Val Leu Glu Thr Ser Trp Glu Ala Leu Glu His Ala Gly Ile Asp Pro 
                85                  90                  95      


His Thr Leu Asn Gly Ser Asp Thr Gly Val Phe Leu Gly Ala Phe Phe 
            100                 105                 110         


Gln Gly Tyr Gly Ile Gly Ala Asp Phe Asp Gly Tyr Gly Thr Thr Ser 
        115                 120                 125             


Ile His Thr Ser Val Leu Ser Gly Arg Leu Ser Tyr Phe Tyr Gly Leu 
    130                 135                 140                 


Glu Gly Pro Ala Val Thr Val Asp Thr Ala Cys Ser Ser Ser Leu Val 
145                 150                 155                 160 


Ala Leu His Gln Ala Gly Gln Ser Leu Arg Thr Gly Glu Cys Ser Leu 
                165                 170                 175     


Ala Leu Val Gly Gly Val Thr Val Met Ala Ser Pro Ala Gly Phe Ala 
            180                 185                 190         


Asp Phe Ser Glu Gln Gly Gly Leu Ala Pro Asp Gly Arg Cys Lys Ala 
        195                 200                 205             


Phe Ala Glu Ala Ala Asp Gly Thr Ala Phe Ser Glu Gly Ser Gly Val 
    210                 215                 220                 


Leu Val Val Glu Arg Leu Ser Asp Ala Glu Arg His Gly His Arg Ile 
225                 230                 235                 240 


Leu Ala Val Val Arg Gly Ser Ala Val Asn Gln Asp Gly Ala Ser Asn 
                245                 250                 255     


Gly Leu Ser Ala Pro Asn Gly Pro Ser Gln Glu Arg Val Ile Arg Gln 
            260                 265                 270         


Ala Leu Ala Asn Ala Gly Leu Gln Pro Ser Asp Val Asp Ala Val Glu 
        275                 280                 285             


Ala His Gly Thr Gly Thr Arg Leu Gly Asp Pro Ile Glu Ala Thr Ala 
    290                 295                 300                 


Leu Leu Ala Thr Tyr Gly Gln His Arg Thr Thr Pro Leu Leu Leu Gly 
305                 310                 315                 320 


Ser Leu Lys Ser Asn Ile Gly His Thr Gln Ala Ala Ala Gly Val Ala 
                325                 330                 335     


Gly Ile Ile Lys Met Val Leu Ala Met His His Asp Thr Leu Pro Pro 
            340                 345                 350         


Thr Leu His Val Asp Thr Pro Ser Ser His Val Asp Trp Thr Thr Gly 
        355                 360                 365             


Gly Val Glu Leu Leu Thr Asp Ala Arg Pro Trp Pro Thr Thr Thr Gly 
    370                 375                 380                 


Pro Arg Arg Ala Gly Ile Ser Ser Phe Gly Val Ser Gly Thr Asn Ala 
385                 390                 395                 400 


His Val Ile Leu Glu Ser Pro Thr Pro Val Pro Ser Pro Gly Ala Glu 
                405                 410                 415     


Pro Gly Ala Arg Pro Val Pro Leu Pro Ile Ser Ala Arg Thr Pro Glu 
            420                 425                 430         


Ala Leu Asp Glu His Thr Ile Arg Ile Arg Ala Phe Leu Asp Asp Asn 
        435                 440                 445             


Pro Gly Ala Asp His Val Ala Val Ala Gln Thr Leu Ala Arg Arg Thr 
    450                 455                 460                 


Pro Phe Glu His Arg Ala Val Leu Leu Gly Asp Thr Leu Ile Thr Ala 
465                 470                 475                 480 


Asp Pro Asn Ala Gly Ser Gly Pro Val Val Phe Val Tyr Ser Gly Gln 
                485                 490                 495     


Ser Thr Leu His Pro His Thr Gly Arg Gln Leu Ala Ala Thr Tyr Pro 
            500                 505                 510         


Val Phe Ala Asp Ala Trp Gly Glu Val Leu Gly His Leu Asp Ala Asp 
        515                 520                 525             


Gln Gly Pro Ala Thr His Phe Ala His Gln Ile Ala Leu Thr Ala Leu 
    530                 535                 540                 


Leu Arg Ser Trp Gly Ile Ala Pro His Ala Val Ile Gly His Ser Leu 
545                 550                 555                 560 


Gly Glu Ile Ser Ala Ala Cys Ala Ala Gly Val Leu Ser Leu Gly Asp 
                565                 570                 575     


Ala Ser Ala Leu Leu Ala Ala Arg Ser Arg Leu Met Asp Glu Leu Pro 
            580                 585                 590         


Ala Gly Gly Ala Met Val Thr Val Leu Thr Ser Glu Glu Asn Ala Leu 
        595                 600                 605             


Arg Ala Leu Arg Pro Gly Val Glu Ile Ala Ala Val Asn Gly Pro His 
    610                 615                 620                 


Ser Val Val Leu Ser Gly Asp Glu Gly Pro Val Leu Ala Val Ala Gln 
625                 630                 635                 640 


Gln Leu Gly Ile His His Arg Leu Pro Thr Arg His Ala Gly His Ser 
                645                 650                 655     


Ala Arg Met Asp Pro Leu Val Ala Pro Leu Leu Glu Ala Ala Ser Gly 
            660                 665                 670         


Leu Thr Tyr His Gln Pro Arg Ile Ala Ile Pro Gly Asp Pro Thr Thr 
        675                 680                 685             


Ala Ala Tyr Trp Ala Arg Gln Val Arg Asp Gln Val Arg Phe Gln Ala 
    690                 695                 700                 


His Ala Glu Arg Tyr Pro Gly Ala Thr Phe Leu Glu Ile Gly Pro Asn 
705                 710                 715                 720 


Gln Asp Leu Ser Pro Val Val Asp Gly Ile Pro Thr Gln Thr Gly Thr 
                725                 730                 735     


Pro Asp Glu Val Gln Ala Leu His Thr Ala Leu Ala Arg Leu His Thr 
            740                 745                 750         


Arg Gly Gly Val Val Asp Trp Pro Thr Val Leu Gly Gly Asp Arg Ala 
        755                 760                 765             


Pro Val Ala Leu Pro Thr Tyr Pro Phe Gln His Lys Asp Tyr Trp Leu 
    770                 775                 780                 


Arg Ala Thr Glu Leu Ala Val Leu Pro Asp Asp Glu Arg Ala Asp Ala 
785                 790                 795                 800 


Leu Leu Ala Phe Val Arg Asn Ser Thr Ala Thr Val Leu Gly His Leu 
                805                 810                 815     


Gly Ala Glu Asp Ile Pro Ala Thr Ala Thr Phe Lys Glu Leu Gly Ile 
            820                 825                 830         


Asp Ser Leu Thr Ala Val Gln Leu Arg Asn Ala Leu Thr Thr Ala Thr 
        835                 840                 845             


Gly Val Arg Leu Asn Ala Thr Ala Val Phe Asp Phe Pro Thr Pro Arg 
    850                 855                 860                 


Ala Leu Ala Ala Arg Leu 
865                 870 


<210>  27
<211>  898
<212>  PRT
<213>  Streptomyces avermitilis

<400>  27

Glu Pro Leu Ala Ile Val Gly Met Ala Cys Arg Leu Pro Gly Gly Val 
1               5                   10                  15      


Ala Ser Pro Glu Gly Leu Trp Arg Leu Val Ala Ser Gly Thr Asp Ala 
            20                  25                  30          


Ile Thr Glu Phe Pro Ala Asp Arg Gly Trp Asp Val Asp Ala Leu Tyr 
        35                  40                  45              


Asp Pro Asp Pro Ala Ile Gly Lys Thr Phe Val Arg His Gly Gly Phe 
    50                  55                  60                  


Leu Asp Gly Ala Thr Gly Phe Asp Ala Gly Phe Phe Gly Ile Ser Pro 
65                  70                  75                  80  


Arg Glu Ala Leu Ala Met Asp Pro Gln Gln Arg Val Leu Leu Glu Thr 
                85                  90                  95      


Ser Trp Glu Ala Phe Glu Ser Ala Gly Ile Thr Pro Asp Ser Ala Arg 
            100                 105                 110         


Gly Ser Asp Thr Gly Val Phe Ile Gly Ala Phe Ser Tyr Gly Tyr Gly 
        115                 120                 125             


Thr Gly Ala Asp Thr Asn Gly Phe Gly Ala Thr Gly Ser Gln Thr Ser 
    130                 135                 140                 


Val Leu Ser Gly Arg Leu Ser Tyr Phe Tyr Gly Leu Glu Gly Pro Ser 
145                 150                 155                 160 


Val Thr Val Asp Thr Ala Cys Ser Ser Ser Leu Val Ala Leu His Gln 
                165                 170                 175     


Ala Gly Gln Ser Leu Arg Ser Gly Glu Cys Ser Leu Ala Leu Val Gly 
            180                 185                 190         


Gly Val Thr Val Met Ala Ser Pro Gly Gly Phe Val Glu Phe Ser Arg 
        195                 200                 205             


Gln Arg Gly Leu Ala Pro Asp Gly Arg Ala Lys Ala Phe Gly Ala Gly 
    210                 215                 220                 


Ala Asp Gly Thr Ser Phe Ala Glu Gly Ala Gly Ala Leu Val Val Glu 
225                 230                 235                 240 


Arg Leu Ser Asp Ala Glu Arg His Gly His Thr Val Leu Ala Val Val 
                245                 250                 255     


Arg Gly Ser Ala Val Asn Ser Asp Gly Ala Ser Asn Gly Leu Ser Ala 
            260                 265                 270         


Pro Asn Gly Pro Ser Gln Glu Arg Val Ile Arg Gln Ala Leu Ala Asn 
        275                 280                 285             


Ala Lys Leu Thr Pro Ala Asp Val Asp Ala Val Glu Ala His Gly Thr 
    290                 295                 300                 


Gly Thr Arg Leu Gly Asp Pro Ile Glu Ala Gln Ala Leu Leu Ala Thr 
305                 310                 315                 320 


Tyr Gly Gln Asp Arg Ala Thr Pro Leu Leu Leu Gly Ser Leu Lys Ser 
                325                 330                 335     


Asn Ile Gly His Ala Gln Ala Ala Ser Gly Val Ala Gly Ile Ile Lys 
            340                 345                 350         


Met Val Gln Ala Ile Arg His Gly Glu Leu Pro Pro Thr Leu His Ala 
        355                 360                 365             


Asp Glu Pro Ser Pro His Val Asp Trp Thr Ala Gly Ala Val Glu Leu 
    370                 375                 380                 


Leu Thr Ser Ala Arg Pro Trp Pro Gly Thr Gly Arg Pro Arg Arg Ala 
385                 390                 395                 400 


Ala Val Ser Ser Phe Gly Val Ser Gly Thr Asn Ala His Ile Ile Leu 
                405                 410                 415     


Glu Ala Gly Pro Val Lys Ala Gly Pro Val Glu Ala Gly Pro Val Pro 
            420                 425                 430         


Ala Ala Pro Pro Ser Ala Pro Gly Glu Asp Leu Pro Leu Leu Val Ser 
        435                 440                 445             


Ala Arg Ser Pro Glu Ala Leu Asp Glu Gln Ile Gly Arg Leu Arg Thr 
    450                 455                 460                 


Tyr Leu Asp Thr Arg Pro Gly Val Asp Arg Ala Ala Val Ala Gln Thr 
465                 470                 475                 480 


Leu Ala Arg Arg Thr His Phe Ala His Arg Ala Val Leu Leu Gly Asp 
                485                 490                 495     


Thr Val Ile Thr Thr Ser Pro Ser His Gln Ala Asp Glu Leu Val Phe 
            500                 505                 510         


Val Tyr Ser Gly Gln Gly Thr Gln His Pro Ala Met Gly Glu Gln Leu 
        515                 520                 525             


Ala Ala Ala Phe Pro Val Phe Ala Glu Thr Trp His Asp Ala Leu Arg 
    530                 535                 540                 


Arg Leu Asp Asp Pro Asp Pro His Asp Pro Thr Arg Ser Gln His Thr 
545                 550                 555                 560 


Leu Phe Ala His Gln Ala Ala Leu Thr Ala Leu Leu Arg Ser Trp Asp 
                565                 570                 575     


Ile Thr Pro His Ala Val Ile Gly His Ser Leu Gly Glu Ile Thr Ala 
            580                 585                 590         


Ala Tyr Ala Ala Gly Ile Leu Ser Leu Asp Asp Ala Cys Thr Leu Ile 
        595                 600                 605             


Thr Thr Arg Ala Arg Leu Met His Thr Leu Pro Pro Pro Gly Ala Met 
    610                 615                 620                 


Val Thr Val Leu Thr Gly Glu Glu Glu Ala Arg Gln Ala Leu Arg Pro 
625                 630                 635                 640 


Gly Val Glu Ile Ala Ala Val Asn Gly Ala His Ser Val Val Leu Ser 
                645                 650                 655     


Gly Asp Glu Asp Ala Val Leu Asp Val Ala Gln Arg Leu Gly Ile His 
            660                 665                 670         


His Arg Leu Pro Ala Pro His Ala Gly His Ser Ala His Met Glu Pro 
        675                 680                 685             


Val Ala Ala Glu Leu Leu Ala Thr Thr Arg Arg Leu Arg Tyr Asp Arg 
    690                 695                 700                 


Pro His Thr Ala Ile Pro Asn Asp Pro Thr Thr Ala Glu Tyr Trp Ala 
705                 710                 715                 720 


Glu Gln Val Arg Asn Pro Val Leu Phe His Ala His Thr Gln Gln Tyr 
                725                 730                 735     


Pro Asp Ala Val Phe Val Glu Ile Gly Pro Gly Gln Asp Leu Ser Pro 
            740                 745                 750         


Leu Val Asp Gly Ile Ala Leu Gln Asn Gly Pro Ala Asn Glu Ala His 
        755                 760                 765             


Ala Leu Arg Thr Ala Leu Ala Arg Leu Phe Ser Arg Gly Ala Thr Leu 
    770                 775                 780                 


Asp Trp Pro Leu Val Leu Gly Gly Ala Ser Arg His Asp Pro Asp Val 
785                 790                 795                 800 


Pro Ser Tyr Ala Phe Gln Gln Arg Pro Tyr Trp Ile Glu Ser Ala Arg 
                805                 810                 815     


Leu Ala Glu Leu Pro Asp Ala Asp Arg Asp Thr Ala Leu Ser Thr Leu 
            820                 825                 830         


Val Met Asp Ala Thr Ala Ala Val Leu Gly His Ala Asp Ala Ser Glu 
        835                 840                 845             


Ile Gly Pro Thr Thr Thr Phe Lys Asp Leu Gly Ile Asp Ser Leu Thr 
    850                 855                 860                 


Ala Ile Glu Leu Arg Asn Arg Leu Ala Glu Ala Thr Gly Leu Arg Leu 
865                 870                 875                 880 


Ser Ala Thr Met Val Phe Asp His Pro Thr Pro Arg Val Leu Ala Ala 
                885                 890                 895     


Lys Leu 
        


<210>  28
<211>  913
<212>  PRT
<213>  Streptomyces kanamyceticus

<400>  28

Glu Pro Leu Ala Ile Val Gly Met Ala Cys Arg Leu Pro Gly Gly Val 
1               5                   10                  15      


Thr Ser Pro Glu Asp Leu Trp Arg Leu Val Ala Ser Gly Thr Asp Ala 
            20                  25                  30          


Ile Thr Glu Phe Pro Thr Asp Arg Gly Trp Asp Ile Asp Arg Met Phe 
        35                  40                  45              


Asp Pro Asp Pro Asp Ala Pro Gly Lys Thr Tyr Val Arg His Gly Gly 
    50                  55                  60                  


Phe Leu Ser Glu Ala Ala Gly Phe Asp Ala Ala Phe Phe Gly Ile Ser 
65                  70                  75                  80  


Pro Arg Glu Ala Trp Ala Met Asp Pro Gln Gln Arg Val Ile Leu Glu 
                85                  90                  95      


Thr Val Trp Glu Ala Phe Glu Asn Ala Gly Ile Val Pro Asp Thr Leu 
            100                 105                 110         


Arg Gly Ser Asp Thr Gly Val Phe Met Gly Ala Phe Ser His Gly Tyr 
        115                 120                 125             


Gly Ala Gly Val Asp Leu Gly Gly Phe Gly Ala Thr Ala Thr Gln Asn 
    130                 135                 140                 


Ser Val Leu Ser Gly Arg Leu Ser Tyr Phe Phe Gly Met Glu Gly Pro 
145                 150                 155                 160 


Ala Val Thr Ile Asp Thr Ala Cys Ser Ser Ser Met Val Ala Leu His 
                165                 170                 175     


Gln Ala Ala Gln Ser Leu Arg Asp Gly Glu Cys Ser Leu Ala Leu Ala 
            180                 185                 190         


Gly Gly Val Thr Val Met Pro Thr Pro Leu Gly Tyr Val Glu Phe Cys 
        195                 200                 205             


Arg Gln Arg Gly Leu Ala Pro Asn Gly Arg Ala Lys Ala Phe Ala Glu 
    210                 215                 220                 


Gly Ala Asp Gly Thr Ser Phe Ser Glu Gly Ala Gly Val Leu Val Val 
225                 230                 235                 240 


Glu Arg Leu Ser Asp Ala Glu Arg Asn Gly His Thr Val Leu Ala Leu 
                245                 250                 255     


Val Arg Ser Ser Ala Val Asn Gln Asp Gly Ala Ser Asn Gly Ile Ser 
            260                 265                 270         


Ala Pro Asn Gly Pro Ser Gln Gln Arg Val Ile Arg Gln Ala Leu Asp 
        275                 280                 285             


Lys Ala Gly Leu Thr Pro Ala Asp Val Asp Val Val Glu Ala His Gly 
    290                 295                 300                 


Thr Gly Thr Pro Leu Gly Asp Pro Ile Glu Ala Gln Ala Ile Ile Ala 
305                 310                 315                 320 


Thr Tyr Gly Gln Asp Arg Asp Thr Pro Leu Tyr Leu Gly Ser Val Lys 
                325                 330                 335     


Ser Asn Ile Gly His Thr Gln Thr Thr Ala Gly Leu Ala Gly Val Ile 
            340                 345                 350         


Lys Met Val Met Ala Met Arg His Gly Leu Leu Pro Lys Thr Leu His 
        355                 360                 365             


Val Asp Glu Pro Ser Ser His Val Asp Trp Ser Ala Gly Ala Val Glu 
    370                 375                 380                 


Leu Leu Thr Glu Ala Arg Pro Trp Pro Asp Ser Asp Arg Pro Arg Arg 
385                 390                 395                 400 


Ala Gly Val Ser Ser Leu Gly Ile Ser Gly Thr Asn Ala His Val Ile 
                405                 410                 415     


Leu Glu Gly Val Ala Glu Ser Ser Val Arg Ser Gly Gly Ser Ser Gly 
            420                 425                 430         


Leu Val Pro Leu Pro Val Ser Ala Arg Thr Glu Ser Ser Leu Ala Leu 
        435                 440                 445             


Gln Val Glu Arg Val Gly Glu Tyr Val Arg Gly Gly Ala Asp Leu Gly 
    450                 455                 460                 


Ala Val Ala Asp Gly Leu Val Arg Gly Arg Ala Val Phe Asp Arg Arg 
465                 470                 475                 480 


Ala Val Leu Leu Gly Glu Ser Thr Val Ala Gly Val Ala Val Glu Gly 
                485                 490                 495     


Ala Arg Thr Val Phe Val Phe Pro Gly Gln Gly Ser Gln Trp Val Gly 
            500                 505                 510         


Met Gly Arg Glu Leu Met Gly Ala Ser Glu Val Phe Ala Ala Arg Met 
        515                 520                 525             


Arg Glu Cys Ala Ala Ala Leu Glu Pro His Thr Gly Trp Asp Val Leu 
    530                 535                 540                 


Asp Val Leu Gly Glu Ala Val Val Ala Asp Arg Val Glu Val Leu Gln 
545                 550                 555                 560 


Pro Ala Ser Trp Ala Val Ala Val Ser Leu Ala Ala Leu Trp Gln Ala 
                565                 570                 575     


His Gly Val Val Pro Asp Ala Val Ile Gly His Ser Gln Gly Glu Ile 
            580                 585                 590         


Ala Ala Ala Cys Val Ala Gly Ala Leu Ser Leu Glu Asp Ala Ala Arg 
        595                 600                 605             


Val Val Ala Leu Arg Ser Gln Thr Ile Ala Ala Arg Leu Gly His Gly 
    610                 615                 620                 


Ala Met Ala Ser Ile Ala Leu Pro Ala Ser Ala Val Glu Val Ala Glu 
625                 630                 635                 640 


Gly Val Trp Ile Ala Ala Arg Asn Gly Pro Glu Ser Thr Val Val Ala 
                645                 650                 655     


Gly Asp Pro Gly Ala Val Glu Arg Val Leu Ala Arg Tyr Glu Ala Ala 
            660                 665                 670         


Gly Val Arg Val Arg Arg Ile Ala Val Asp Tyr Ala Ser His Thr Pro 
        675                 680                 685             


His Val Glu Ala Ile Glu Glu Gln Leu Ala Asp Val Leu Gly Gly Ile 
    690                 695                 700                 


Thr Ser Ser Ala Pro Asp Ile Ser Trp Trp Ser Thr Val Asp Ser Gly 
705                 710                 715                 720 


Trp Val Thr Glu Pro Val Gly Asp Asp Tyr Trp Tyr Arg Asn Leu Arg 
                725                 730                 735     


Gln Pro Val Ala Met Asp Thr Ala Ile Ser Glu Leu Asp Gly Ser Leu 
            740                 745                 750         


Phe Ile Glu Cys Ser Ala His Pro Val Leu Leu Pro Ala Leu Asp Gln 
        755                 760                 765             


Glu His Thr Val Ala Ser Leu Arg Thr Asp Asp Gly Asp Trp Asp Arg 
    770                 775                 780                 


Phe Leu Thr Ala Leu Ala Gln Ala Trp Thr Gln Gly Ala Pro Val Asp 
785                 790                 795                 800 


Trp Thr Thr Leu Ile Glu Pro Ala Pro His Arg Leu Asp Leu Pro Thr 
                805                 810                 815     


Tyr Pro Phe Asp His Lys Arg Tyr Trp Ile Glu Ala Ala Ala Arg Leu 
            820                 825                 830         


Ala Gly His Thr Ala Ala Glu Gln Arg Arg Val Met Gln Glu Val Val 
        835                 840                 845             


Leu Arg Gln Ala Ala Ala Val Leu Ala Tyr Gly Leu Gly Glu Gln Val 
    850                 855                 860                 


Ala Ala Asp Arg Pro Phe Arg Asp Leu Gly Phe Asp Ser Leu Thr Ala 
865                 870                 875                 880 


Val Asp Leu Arg Asn Arg Leu Ala Ala Glu Thr Gly Leu Arg Leu Pro 
                885                 890                 895     


Thr Thr Val Val Phe Ser His Pro Thr Ala Glu Ala Leu Ala Thr His 
            900                 905                 910         


Leu 
    


<210>  29
<211>  936
<212>  PRT
<213>  Streptomyces kanamyceticus

<400>  29

Glu Pro Ile Ala Ile Val Ala Met Ala Cys Arg Leu Pro Gly Gly Val 
1               5                   10                  15      


Thr Ser Pro Glu Glu Leu Trp Arg Leu Val Glu Ser Gly Thr Asp Ala 
            20                  25                  30          


Ile Thr Met Ala Pro Gly Asp Arg Gly Trp Asp Leu Asp Ala Leu Tyr 
        35                  40                  45              


Asp Pro Asp Pro Asp Ala Val Gly Lys Ala Tyr Asn Leu Arg Gly Gly 
    50                  55                  60                  


Phe Leu Glu Gly Ala Ala Glu Phe Asp Ala Ala Phe Phe Asp Ile Ser 
65                  70                  75                  80  


Pro Arg Glu Ser Leu Gly Met Asp Pro Gln Gln Arg Leu Leu Leu Glu 
                85                  90                  95      


Thr Ala Trp Glu Ala Ile Glu Arg Gly Arg Ile Asn Pro Ala Ser Leu 
            100                 105                 110         


His Gly Arg Glu Ile Gly Val Tyr Val Gly Ala Ala Ala Gln Gly Tyr 
        115                 120                 125             


Gly Leu Gly Ala Glu Asp Thr Glu Gly Asn Ala Ile Thr Gly Gly Ser 
    130                 135                 140                 


Thr Ser Leu Leu Ser Gly Arg Leu Ala Tyr Val Leu Gly Leu Glu Gly 
145                 150                 155                 160 


Pro Ser Val Thr Val Asp Thr Ala Cys Ser Ser Ser Leu Val Ala Leu 
                165                 170                 175     


His Leu Ala Cys Gln Gly Leu Arg Leu Gly Glu Cys Glu Leu Ala Leu 
            180                 185                 190         


Ala Gly Gly Val Ser Val Leu Ser Ser Pro Ala Ala Phe Val Glu Phe 
        195                 200                 205             


Ser Arg Gln Arg Gly Leu Ala Ala Asp Gly Arg Cys Lys Ser Phe Gly 
    210                 215                 220                 


Ser Gly Ala Asp Gly Thr Thr Trp Ala Glu Gly Val Gly Val Leu Val 
225                 230                 235                 240 


Leu Glu Arg Leu Ser Asp Ala Glu Arg Leu Gly His Thr Val Leu Ala 
                245                 250                 255     


Val Val Arg Gly Ser Ala Val Thr Ser Asp Gly Ala Ser Asn Gly Leu 
            260                 265                 270         


Thr Ala Pro Asn Gly Leu Ala Gln Gln Arg Val Ile Arg Lys Ala Leu 
        275                 280                 285             


Ala Ala Ala Gly Leu Thr Ala Ala Asp Val Asp Leu Val Glu Gly His 
    290                 295                 300                 


Gly Thr Gly Thr Arg Leu Gly Asp Pro Val Glu Ala Asp Ala Leu Leu 
305                 310                 315                 320 


Ala Thr Tyr Gly Gln Asn Arg Gln Glu Pro Val Trp Leu Gly Ser Leu 
                325                 330                 335     


Lys Ser Asn Ile Gly His Ala Thr Ala Ala Ala Gly Val Ala Gly Val 
            340                 345                 350         


Ile Lys Thr Val Gln Ala Ile Gly Ala Gly Thr Met Pro Arg Thr Leu 
        355                 360                 365             


His Ala Asp Glu Pro Ser Pro Ala Val Asp Trp Thr Ala Gly Arg Val 
    370                 375                 380                 


Ser Leu Leu Thr Gly Asn Arg Pro Trp Pro Asp Asp Glu Arg Ala Arg 
385                 390                 395                 400 


Arg Ala Ala Val Ser Ala Phe Gly Leu Ser Gly Thr Asn Ala His Val 
                405                 410                 415     


Ile Leu Glu Gln His Arg Pro Glu Pro Val Ala Pro Arg Pro Pro Arg 
            420                 425                 430         


Glu Glu Pro Arg Pro Leu Pro Trp Val Leu Ser Ala Arg Thr Pro Ala 
        435                 440                 445             


Ala Leu Arg Ala Gln Ala Ala Arg Leu Arg Asp His Leu Ala Ala Val 
    450                 455                 460                 


Pro Asp Ala Asp Pro Leu Asp Ile Gly Tyr Ala Leu Ala Thr Ser Arg 
465                 470                 475                 480 


Ala Arg Phe Thr His Arg Ala Ala Val Val Ala Thr Ser Ser Asp Glu 
                485                 490                 495     


Phe Arg Ala Gly Leu Asp Ser Val Ala Asp Gly Val Glu Ala Pro Gly 
            500                 505                 510         


Val Val Gly Gly Thr Ala Arg Glu Arg Arg Val Ala Phe Leu Phe Asp 
        515                 520                 525             


Gly Gln Gly Ala Gln Arg Val Gly Met Gly Arg Glu Leu His Gly Arg 
    530                 535                 540                 


Phe Pro Val Phe Ala Ala Ala Trp Asp Glu Val Ser Asp Ala Phe Gly 
545                 550                 555                 560 


Lys His Leu Glu His Ser Pro Thr Asp Val Phe His Gly Glu His Gly 
                565                 570                 575     


Asp Leu Ala His Asp Thr Leu Tyr Ala Gln Val Gly Leu Phe Thr Leu 
            580                 585                 590         


Glu Val Ala Leu Leu Arg Leu Leu Glu His Trp Gly Val Arg Pro Asp 
        595                 600                 605             


Val Leu Val Gly His Ser Val Gly Glu Val Thr Ala Ala Tyr Ala Ala 
    610                 615                 620                 


Gly Val Leu Thr Leu Ala Asp Ala Thr Ala Leu Ile Val Ala Arg Gly 
625                 630                 635                 640 


Arg Ala Leu Arg Ala Leu Pro Pro Gly Ala Met Thr Ala Val Asp Gly 
                645                 650                 655     


Ser Pro Ala Glu Val Gly Ala Phe Thr Gly Leu Asp Ile Ala Ala Val 
            660                 665                 670         


Asn Gly Pro Ser Ala Val Val Leu Thr Gly Ser Pro Asp Asp Val Thr 
        675                 680                 685             


Ala Phe Glu Arg Glu Trp Ala Ala Ala Gly Arg Arg Ala Lys Arg Leu 
    690                 695                 700                 


Asp Val Gly His Ala Phe His Ser Arg His Val Asp Gly Ala Leu Asp 
705                 710                 715                 720 


Asp Phe Arg Thr Val Leu Glu Ser Leu Ser Phe Gly Ala Ala Arg Leu 
                725                 730                 735     


Pro Val Val Ser Thr Thr Thr Gly Arg Asp Ala Ala Gly Asp Leu Ala 
            740                 745                 750         


Thr Pro Glu His Trp Leu Arg His Ala Arg Arg Pro Val Leu Phe Ala 
        755                 760                 765             


Asp Ala Val Arg Glu Leu Ala Asp Leu Gly Val Asn Met Phe Val Ala 
    770                 775                 780                 


Val Gly Pro Ser Gly Ala Leu Ala Ser Ala Ala Ser Glu Asn Thr Gly 
785                 790                 795                 800 


Gly Ser Ala Gly Thr Tyr His Ala Val Leu Arg Ala Arg Thr Gly Glu 
                805                 810                 815     


Glu Asn Ala Ala Leu Thr Ala Val Ala Glu Leu His Ala His Gly Ala 
            820                 825                 830         


Pro Val Asp Leu Ala Ala Val Leu Ala Gly Gly Arg Pro Val Asp Leu 
        835                 840                 845             


Pro Val Tyr Pro Phe Gln His Arg Ser Tyr Trp Leu Ala Pro Asp Asp 
    850                 855                 860                 


Leu Thr Val Ala Glu Ile Val Arg Arg Arg Ala Ala Ala Leu Leu Gly 
865                 870                 875                 880 


Ile Ala Asp Pro Gly Asp Val Asp Ala Asp Thr Thr Phe Phe Ala Leu 
                885                 890                 895     


Gly Phe Asp Ser Leu Ala Val Gln Arg Leu Arg Asn Gln Leu Thr Ala 
            900                 905                 910         


Ala Thr Gly Leu Asp Leu Pro Thr Ala Val Leu Phe Asp His Asp Thr 
        915                 920                 925             


Pro Ser Ala Leu Thr Ala Tyr Leu 
    930                 935     


<210>  30
<211>  901
<212>  PRT
<213>  Streptomyces violaceusniger

<400>  30

Glu Pro Leu Ala Ile Val Gly Met Ala Cys Arg Leu Pro Gly Gly Val 
1               5                   10                  15      


Ser Ser Pro Glu Asp Leu Trp Arg Leu Val Glu Ser Gly Thr Asp Ala 
            20                  25                  30          


Ile Ser Gly Phe Pro Thr Asp Arg Gly Trp Asp Val Glu Asn Leu Tyr 
        35                  40                  45              


Asp Pro Asp Pro Asp Ala Ser Gly Lys Ser Tyr Cys Val Gln Gly Gly 
    50                  55                  60                  


Phe Leu Asp Ala Ala Ala Gly Phe Asp Ala Gly Phe Phe Gly Ile Ser 
65                  70                  75                  80  


Pro Arg Glu Ala Leu Ala Met Asp Pro Gln Gln Arg Leu Val Leu Glu 
                85                  90                  95      


Val Ser Trp Glu Ala Phe Glu Arg Ala Gly Ile Glu Pro Gly Ser Val 
            100                 105                 110         


Arg Gly Thr Asp Thr Gly Val Phe Ile Gly Ala Tyr Pro Gly Gly Tyr 
        115                 120                 125             


Gly Ala Gly Ala Gly Thr Glu Leu Glu Gly Tyr Gly Thr Thr Ser Gly 
    130                 135                 140                 


Pro Ser Val Leu Ser Gly Arg Val Ser Tyr Phe Phe Gly Leu Glu Gly 
145                 150                 155                 160 


Pro Ala Ile Thr Val Asp Thr Ala Cys Ser Ser Ser Leu Val Ala Leu 
                165                 170                 175     


His Gln Ala Gly Tyr Ala Leu Arg Gln Gly Glu Cys Ser Leu Ala Leu 
            180                 185                 190         


Val Gly Gly Val Thr Val Met Ala Thr Pro Asp Val Phe Thr Glu Phe 
        195                 200                 205             


Ala Arg Gln Arg Gly Leu Ala Ala Asp Gly Arg Ser Lys Ala Phe Ser 
    210                 215                 220                 


Asp Ser Ala Asp Gly Ala Gly Phe Ser Glu Gly Ile Gly Val Leu Leu 
225                 230                 235                 240 


Val Glu Arg Leu Ser Asp Ala Gln Ala Lys Gly His Gln Val Leu Ala 
                245                 250                 255     


Val Val Arg Ser Ser Ala Val Asn Gln Asp Gly Ala Ser Asn Gly Leu 
            260                 265                 270         


Thr Ala Pro Asn Gly Pro Ser Gln Gln Arg Val Ile Gln Ala Ala Leu 
        275                 280                 285             


Gly Asn Ala Gly Leu Thr Thr Ala Glu Val Asp Val Val Glu Gly His 
    290                 295                 300                 


Gly Thr Gly Thr Thr Leu Gly Asp Pro Ile Glu Ala Gln Ala Leu Leu 
305                 310                 315                 320 


Ala Thr Tyr Gly Gln Asp Arg Glu Arg Pro Leu Leu Leu Gly Ser Leu 
                325                 330                 335     


Lys Ser Asn Ile Gly His Thr Gln Ala Ala Ala Gly Val Ser Gly Val 
            340                 345                 350         


Ile Lys Met Val Met Ala Leu Arg His Gly Leu Val Pro Arg Thr Leu 
        355                 360                 365             


His Val Asp Glu Pro Ser Ser His Val Asp Trp Thr Ala Gly Ala Val 
    370                 375                 380                 


Glu Leu Val Thr Ala Asn Gln Pro Trp Pro Asp Ala Asp Arg Pro Arg 
385                 390                 395                 400 


Arg Ala Gly Val Ser Ser Phe Gly Val Ser Gly Thr Asn Ala His Val 
                405                 410                 415     


Ile Leu Glu Ser Ala Pro Ser Thr Gln Ala Val Asp Asp Val Arg Pro 
            420                 425                 430         


Val Glu Thr Pro Val Val Gly Ser Glu Leu Val Pro Leu Val Leu Ser 
        435                 440                 445             


Ala Lys Thr Leu Pro Ala Leu Ser Gly Tyr Glu Asp Arg Leu Arg Ala 
    450                 455                 460                 


Tyr Leu Ala Gly Ser Pro Gly Val Asp Leu Arg Ala Val Ala Ser Thr 
465                 470                 475                 480 


Leu Ala Val Thr Arg Ser Val Phe Glu His Arg Ala Val Leu Leu Gly 
                485                 490                 495     


Asp Asp Thr Val Thr Gly Thr Ala Val Thr Asp Pro Arg Val Val Phe 
            500                 505                 510         


Ile Phe Pro Gly Gln Gly Ser Gln Arg Ala Gly Met Gly Glu Glu Leu 
        515                 520                 525             


Ala Ala Ala Phe Pro Val Phe Ala Arg Ile His Gln Gln Val Trp Asp 
    530                 535                 540                 


Leu Leu Asp Val Pro Asp Leu Glu Val Asn Glu Thr Gly Tyr Ala Gln 
545                 550                 555                 560 


Pro Ala Leu Phe Ala Leu Gln Val Ala Leu Phe Gly Leu Leu Glu Ser 
                565                 570                 575     


Trp Gly Val Gly Pro Asp Ala Val Val Gly His Ser Val Gly Glu Leu 
            580                 585                 590         


Ala Ala Ala Tyr Val Ser Gly Val Trp Ser Leu Glu Asp Ala Cys Thr 
        595                 600                 605             


Leu Val Ser Ala Arg Ala Arg Leu Met Gln Ala Leu Pro Pro Gly Gly 
    610                 615                 620                 


Val Met Val Ala Val Pro Val Pro Glu Asp Glu Ala Arg Ala Val Leu 
625                 630                 635                 640 


Gly Glu Gly Val Glu Ile Ala Ala Val Asn Gly Pro Ser Ser Val Val 
                645                 650                 655     


Leu Ser Gly Asp Glu Ala Ala Val Leu Arg Ala Ala Ala Thr Leu Gly 
            660                 665                 670         


Lys Trp Met Arg Leu Ala Thr Ser His Ala Phe His Ser Ala Arg Met 
        675                 680                 685             


Glu Pro Met Leu Asp Glu Phe Arg Ala Val Ala Glu Arg Leu Thr Tyr 
    690                 695                 700                 


Gln Thr Pro His Leu Thr Met Ala Ala Gly Glu Gln Val Thr Thr Pro 
705                 710                 715                 720 


Asp Tyr Trp Val Arg Gln Val Arg Asp Val Val Arg Phe Gly Glu Gln 
                725                 730                 735     


Val Ala Ser Phe Glu Asp Ala Val Phe Val Glu Leu Gly Ala Asp Arg 
            740                 745                 750         


Ser Leu Ala Arg Leu Val Asp Gly Val Ala Met Leu His Gly Ala His 
        755                 760                 765             


Glu Ala Gln Ala Ala Ile Ser Ala Leu Ala His Leu Tyr Val Asn Gly 
    770                 775                 780                 


Val Thr Val Asp Trp Pro Ala Val Leu Gly Asp Val Pro Gly Arg Val 
785                 790                 795                 800 


Leu Asp Leu Pro Thr Tyr Ala Phe Gln His Gln Arg Tyr Trp Leu Glu 
                805                 810                 815     


Gly Trp Leu Ala Ala Leu Thr Pro Ala Glu Arg Glu Lys Ala Leu Leu 
            820                 825                 830         


Lys Leu Val Ser Asp Gly Ala Ala Thr Val Leu Gly His Ala Asp Thr 
        835                 840                 845             


Ser Thr Ile Pro Val Thr Gly Ala Phe Lys Asp Leu Gly Ile Asn Ser 
    850                 855                 860                 


Leu Thr Ala Val Glu Leu Arg Asn Ser Leu Ala Lys Ala Thr Glu Leu 
865                 870                 875                 880 


Arg Leu Pro Ala Thr Leu Val Phe Asp Tyr Pro Thr Pro Ala Thr Leu 
                885                 890                 895     


Ala Ala Arg Leu Asp 
            900     


<210>  31
<211>  890
<212>  PRT
<213>  Streptomyces violaceusniger

<400>  31

Glu Pro Leu Ala Ile Val Gly Met Ala Cys Arg Leu Pro Gly Gly Val 
1               5                   10                  15      


Ser Ser Pro Glu Asp Leu Trp Arg Leu Val Glu Ser Gly Thr Asp Ala 
            20                  25                  30          


Ile Ser Gly Phe Pro Thr Asp Arg Gly Trp Asp Val Glu Asn Leu Asp 
        35                  40                  45              


Ser Ala Gly Lys Ser Tyr Arg Ala Glu Gly Gly Phe Leu Asp Ala Ala 
    50                  55                  60                  


Ala Gly Phe Asp Ala Ser Phe Phe Gly Ile Ser Pro Arg Glu Ala Leu 
65                  70                  75                  80  


Ala Met Asp Pro Gln Gln Arg Leu Val Leu Glu Val Ser Trp Glu Ala 
                85                  90                  95      


Phe Glu Arg Ala Gly Ile Glu Pro Gly Ser Leu Arg Gly Ser Asp Thr 
            100                 105                 110         


Gly Val Phe Met Gly Ala Tyr Pro Gly Gly Tyr Gly Ile Gly Ala Asp 
        115                 120                 125             


Leu Gly Gly Phe Gly Ala Thr Ala Gly Ala Thr Ser Val Leu Ser Gly 
    130                 135                 140                 


Arg Val Ser Tyr Phe Phe Gly Leu Glu Gly Pro Ala Phe Thr Val Asp 
145                 150                 155                 160 


Thr Ala Cys Ser Ser Ser Leu Val Ala Leu His Gln Ala Gly Tyr Ala 
                165                 170                 175     


Leu Arg Gln Gly Glu Cys Ser Leu Ala Leu Val Gly Gly Val Thr Val 
            180                 185                 190         


Met Ala Thr Pro Gln Thr Phe Val Glu Phe Ser Arg Gln Gly Gly Leu 
        195                 200                 205             


Ala Ser Asp Gly Arg Cys Lys Ala Phe Ala Asp Ala Ala Asp Gly Thr 
    210                 215                 220                 


Gly Trp Ala Glu Gly Val Gly Val Leu Leu Val Glu Arg Leu Ser Asp 
225                 230                 235                 240 


Ala Gln Ala Lys Gly His Gln Val Leu Ala Val Val Arg Ser Ser Ala 
                245                 250                 255     


Val Asn Gln Asp Gly Ala Ser Asn Gly Leu Thr Ala Pro Asn Gly Pro 
            260                 265                 270         


Ser Gln Gln Arg Val Ile Gln Ala Ala Leu Ser Asn Ala Gly Leu Thr 
        275                 280                 285             


Thr Ala Glu Val Asp Val Val Glu Ala His Gly Thr Gly Thr Thr Leu 
    290                 295                 300                 


Gly Asp Pro Ile Glu Ala Gln Ala Leu Leu Ala Thr Tyr Gly Gln Asp 
305                 310                 315                 320 


Arg Glu Arg Pro Leu Leu Leu Gly Ser Val Lys Ser Asn Leu Gly His 
                325                 330                 335     


Thr Gln Ala Ala Ala Gly Val Ser Gly Val Ile Lys Met Val Met Ala 
            340                 345                 350         


Leu Arg His Gly Leu Val Pro Arg Thr Leu His Val Asp Glu Pro Ser 
        355                 360                 365             


Arg His Val Asp Trp Ser Thr Gly Ala Val Glu Leu Val Thr Glu Asn 
    370                 375                 380                 


Gln Pro Trp Pro Glu Thr Gly Arg Pro Arg Arg Ala Gly Val Ser Ser 
385                 390                 395                 400 


Phe Gly Ile Ser Gly Thr Asn Ala His Val Ile Leu Glu Ser Ala Pro 
                405                 410                 415     


Ser Ala Gln Val Val Glu Asn Thr Val Val Glu Ser Ala Pro Glu Trp 
            420                 425                 430         


Val Pro Leu Val Val Ser Ala Arg Thr Gln Ser Ala Leu Ala Asp Tyr 
        435                 440                 445             


Glu Asp Arg Leu Arg Ala Tyr Leu Ala Gly Ser Pro Gly Val Asp Leu 
    450                 455                 460                 


Arg Ala Val Ala Ser Thr Leu Ala Val Thr Arg Ser Val Phe Glu His 
465                 470                 475                 480 


Arg Ala Val Leu Val Gly Asp Asp Thr Val Thr Gly Ser Ala Val Ser 
                485                 490                 495     


Asp Pro Arg Val Val Phe Val Phe Pro Gly Gln Gly Ser Gln Arg Ala 
            500                 505                 510         


Gly Met Gly Glu Glu Leu Ala Ala Ala Phe Pro Leu Phe Ala Gln Ile 
        515                 520                 525             


His Gln Gln Val Trp Asp Leu Leu Asp Val Pro Asp Leu Glu Val Asn 
    530                 535                 540                 


Glu Thr Gly Tyr Ala Gln Pro Ala Leu Phe Ala Leu Gln Val Ala Leu 
545                 550                 555                 560 


Phe Gly Leu Leu Glu Ser Trp Gly Val Arg Pro Asp Ala Val Ile Gly 
                565                 570                 575     


His Ser Val Gly Glu Leu Ala Ala Gly Tyr Val Cys Gly Val Trp Ser 
            580                 585                 590         


Leu Glu Asp Ala Cys Thr Met Val Ser Ala Arg Ala Arg Leu Met Gln 
        595                 600                 605             


Ala Leu Pro Ala Gly Gly Val Met Val Ala Val Pro Val Ser Glu Asp 
    610                 615                 620                 


Glu Ala Arg Ala Val Leu Gly Glu Gly Val Glu Ile Ala Ala Val Asn 
625                 630                 635                 640 


Gly Pro Leu Ser Val Ile Leu Ser Gly Asp Glu Ala Ala Val Leu Arg 
                645                 650                 655     


Ala Ala Ala Thr Leu Gly Lys Trp Thr Arg Leu Ala Thr Ser His Ala 
            660                 665                 670         


Phe His Ser Ala Arg Met Glu Pro Met Leu Glu Lys Phe Arg Ala Val 
        675                 680                 685             


Ala Glu Gly Leu Thr Tyr Arg Thr Pro Arg Leu Thr Met Ala Ala Gly 
    690                 695                 700                 


Asp Gln Val Ala Thr Ala Glu Tyr Trp Val Arg Gln Val Arg Asp Val 
705                 710                 715                 720 


Val Arg Phe Gly Glu Gln Val Ala Ser Phe Glu Asp Ala Val Phe Leu 
                725                 730                 735     


Glu Leu Gly Ala Asp Arg Ser Leu Ala Arg Leu Val Asp Gly Ile Ala 
            740                 745                 750         


Met Leu His Gly Asp His Glu Ala Gln Ala Ala Ile Ser Ala Leu Ala 
        755                 760                 765             


His Leu Tyr Val Asn Gly Met Ala Val Asp Trp Pro Ala Val Leu Gly 
    770                 775                 780                 


Asp Val Arg Gly Arg Val Leu Asp Leu Pro Thr Tyr Ala Phe Glu His 
785                 790                 795                 800 


Gln Arg Tyr Trp Leu Glu Gly Trp Leu Ala Val Leu Ala Pro Ala Glu 
                805                 810                 815     


Arg Glu Lys Ala Leu Leu Lys Leu Val Arg Asp Ser Ala Ala Leu Val 
            820                 825                 830         


Leu Gly His Ala Asp Ala Ser Thr Ile Pro Val Ala Ala Ala Phe Lys 
        835                 840                 845             


Asp Leu Gly Ile Asp Ser Leu Thr Ala Val Glu Leu Arg Asn Ser Leu 
    850                 855                 860                 


Ala Lys Ala Thr Gly Leu Arg Leu Pro Asn Thr Thr Val Phe Asp Tyr 
865                 870                 875                 880 


Pro Thr Pro Ala Ile Leu Ala Ala Arg Leu 
                885                 890 


<210>  32
<211>  928
<212>  PRT
<213>  Streptomyces violaceusniger

<400>  32

Glu Pro Leu Ala Ile Val Gly Met Ala Cys Arg Leu Pro Gly Gly Val 
1               5                   10                  15      


Ser Ser Pro Glu Asp Leu Trp Arg Leu Val Glu Ser Gly Thr Asp Ala 
            20                  25                  30          


Ile Ser Gly Phe Pro Thr Asp Arg Gly Trp Asp Ala Glu Ser Leu Tyr 
        35                  40                  45              


Asp Ala Asp Pro Asp Ala Pro Gly Lys Ser Tyr Cys Val Glu Gly Gly 
    50                  55                  60                  


Phe Leu Asp Asn Ala Ser Ser Phe Asp Ala Gly Phe Phe Gly Ile Ser 
65                  70                  75                  80  


Pro Arg Glu Ala Leu Ala Met Asp Pro Gln Gln Arg Leu Val Leu Glu 
                85                  90                  95      


Val Ser Trp Glu Ala Phe Glu Arg Ala Gly Ile Glu Pro Gly Ser Ile 
            100                 105                 110         


Arg Gly Thr Asp Thr Gly Val Phe Met Gly Ala Tyr Ala Gly Gly Tyr 
        115                 120                 125             


Gly Ala Gly Ala Asp Leu Gly Gly Phe Ala Ala Thr Ala Ser Ala Thr 
    130                 135                 140                 


Ser Val Leu Ser Gly Arg Val Ser Tyr Phe Phe Gly Leu Glu Gly Pro 
145                 150                 155                 160 


Ala Ile Thr Val Asp Thr Ala Cys Ser Ser Ser Leu Val Ala Leu His 
                165                 170                 175     


Gln Ala Gly Tyr Ala Leu Arg Gln Gly Glu Cys Ser Leu Ala Leu Val 
            180                 185                 190         


Gly Gly Ala Thr Val Met Ala Thr Pro Gln Ser Phe Val Glu Phe Ser 
        195                 200                 205             


Arg Gln Arg Gly Leu Ala Ser Asp Gly Arg Cys Lys Ala Phe Ala Asp 
    210                 215                 220                 


Ala Ala Asp Gly Thr Gly Trp Ala Glu Gly Val Gly Val Leu Leu Val 
225                 230                 235                 240 


Glu Arg Leu Ser Asp Ala Arg Arg Asn Gly His Gln Val Leu Ala Val 
                245                 250                 255     


Val Arg Ser Ser Ala Val Asn Gln Asp Gly Ala Ser Asn Gly Leu Thr 
            260                 265                 270         


Ala Pro Asn Gly Pro Ser Gln Gln Arg Val Ile Gln Ala Ala Leu Ser 
        275                 280                 285             


Asn Ala Gly Leu Ala Ala His Glu Val Asp Val Val Glu Ala His Gly 
    290                 295                 300                 


Thr Gly Thr Thr Leu Gly Asp Pro Ile Glu Ala Gln Ala Val Leu Ala 
305                 310                 315                 320 


Thr Tyr Gly Gln Asp Arg Glu Arg Pro Leu Leu Leu Gly Ser Leu Lys 
                325                 330                 335     


Ser Asn Ile Gly His Thr Gln Ala Ala Ser Gly Val Ser Gly Val Ile 
            340                 345                 350         


Lys Met Val Met Ala Leu Gln His His Thr Val Pro Arg Thr Leu His 
        355                 360                 365             


Val Asn Glu Pro Ser Arg His Val Asp Trp Ser Ala Gly Ala Val Glu 
    370                 375                 380                 


Leu Val Arg Glu Asn Gln Ser Trp Pro Glu Gly Asp Arg Pro Arg Arg 
385                 390                 395                 400 


Ala Gly Val Ser Ser Phe Gly Val Ser Gly Thr Asn Ala His Ile Ile 
                405                 410                 415     


Leu Glu Ser Ala Pro Ala Gln Ser Ala Glu Glu Val Gln Pro Val Glu 
            420                 425                 430         


Val Pro Val Val Ala Ser Asp Val Leu Pro Leu Val Val Ser Ala Lys 
        435                 440                 445             


Thr His Ser Ala Leu Thr Glu Ala Glu Asp Arg Leu Arg Ala Tyr Leu 
    450                 455                 460                 


Thr Ala Ser Pro Glu Ala Asp Met Pro Ala Val Ala Ser Thr Leu Ala 
465                 470                 475                 480 


Val Thr Arg Ser Val Phe Glu His Arg Ala Val Leu Leu Gly Asp Asp 
                485                 490                 495     


Thr Val Thr Gly Thr Gly Thr Ala Met Ser Asp Pro Arg Val Val Phe 
            500                 505                 510         


Val Phe Pro Gly Gln Gly Trp Gln Trp Leu Gly Met Gly Ser Ala Leu 
        515                 520                 525             


Arg Glu Ser Ser Val Val Phe Ala Glu Arg Met Ala Glu Cys Ala Ala 
    530                 535                 540                 


Ala Leu Ser Asp Phe Val Asp Trp Asp Leu Phe Thr Val Leu Asp Asp 
545                 550                 555                 560 


Pro Ala Val Val Asp Arg Val Asp Val Val Gln Pro Ala Ser Trp Ala 
                565                 570                 575     


Val Met Val Ser Leu Ala Ala Val Trp Gln Ala Ala Gly Val Arg Pro 
            580                 585                 590         


Asp Ala Val Ile Gly His Ser Gln Gly Glu Ile Ala Ala Ala Cys Ile 
        595                 600                 605             


Ala Gly Ala Val Ser Leu Arg Asp Ala Ala Arg Ile Val Thr Leu Arg 
    610                 615                 620                 


Ser Gln Ala Ile Ala Arg Gly Pro Ala Gly Arg Gly Ala Met Ala Ser 
625                 630                 635                 640 


Ile Ala Leu Pro Ala Gln Glu Ile Glu Leu Ala Asp Gly Ala Trp Ile 
                645                 650                 655     


Ala Ala His Asn Gly Pro Ala Ser Thr Val Ile Ala Gly Thr Pro Glu 
            660                 665                 670         


Ala Val Asp Leu Val Leu Thr Ala His Glu Ala Gln Gly Thr Arg Val 
        675                 680                 685             


Arg Arg Ile Thr Val Asp Tyr Ala Ser His Thr Pro His Val Glu Leu 
    690                 695                 700                 


Ile Arg Asp Glu Leu Leu His Ile Thr Ala Gly Ile Gly Ser Gln Val 
705                 710                 715                 720 


Pro Val Val Pro Trp Leu Ser Thr Val Asp Gly Thr Trp Val Glu Gly 
                725                 730                 735     


Pro Leu Asp Ala Glu Tyr Trp Tyr Arg Asn Leu Arg Glu Pro Val Gly 
            740                 745                 750         


Phe Ala Pro Ala Ile Ser Gln Leu Gln Ala Gln Gly Glu Thr Val Phe 
        755                 760                 765             


Ile Glu Val Ser Ala Ser Pro Val Leu Leu Gln Ala Met Asp Asp Asp 
    770                 775                 780                 


Ala Val Thr Val Ala Thr Leu Arg Arg Asp Asp Gly Asp Ala Thr Arg 
785                 790                 795                 800 


Ile Leu Thr Ala Leu Ala Gln Ala Tyr Thr His Gly Val Thr Val Asp 
                805                 810                 815     


Trp Pro Ala Ile Leu Gly Thr Thr Thr Thr Arg Ala Leu Asp Leu Pro 
            820                 825                 830         


Thr Tyr Ala Phe Gln His Gln Arg Tyr Trp Leu Asn Asn Arg Leu Thr 
        835                 840                 845             


Gly Arg Thr Ser Val Glu Gln His Arg Val Met Leu Glu Leu Val Leu 
    850                 855                 860                 


Gly Glu Ala Ala Ser Val Leu Gly His Gly Ser Pro Asp Ala Ile Ala 
865                 870                 875                 880 


Thr Asp Thr Ser Phe Lys Asp Leu Gly Met Asp Ser Leu Thr Ala Ile 
                885                 890                 895     


Glu Leu Arg Asn Arg Leu Met Ala Glu Thr Gly Leu Gln Leu Pro Ala 
            900                 905                 910         


Thr Met Val Phe Asp Tyr Pro Thr Ala Asn Ala Leu Ala Thr His Leu 
        915                 920                 925             


<210>  33
<211>  962
<212>  PRT
<213>  Streptomyces violaceusniger

<400>  33

Glu Pro Ile Ala Ile Val Ala Met Ala Cys Arg Val Pro Gly Gly Val 
1               5                   10                  15      


Ser Ser Pro Glu Gly Leu Trp Arg Leu Val Glu Ser Gly Thr Asp Val 
            20                  25                  30          


Ile Ser Gly Phe Pro Thr Asp Arg Gly Trp Asp Val Glu Gly Leu Phe 
        35                  40                  45              


Asp Pro Asp Pro Asp Ala Pro Gly Lys Ser Tyr Cys Val Gln Gly Gly 
    50                  55                  60                  


Phe Leu Asp Thr Ala Ala Asp Phe Asp Ala Pro Phe Phe Gly Ile Ser 
65                  70                  75                  80  


Pro Arg Glu Ala Leu Gly Met Asp Pro Gln Gln Arg Leu Leu Leu Glu 
                85                  90                  95      


Thr Thr Trp Glu Ala Ile Glu Arg Ala Arg Ile Asp Pro Lys Ser Leu 
            100                 105                 110         


Arg Gly Arg Asp Val Gly Val Tyr Val Gly Gly Ala Ala Gln Gly Tyr 
        115                 120                 125             


Gly Val Gly Val Asp Gln Gln Arg Asp Asn Gly Ile Thr Gly Ser Ser 
    130                 135                 140                 


Val Ser Leu Leu Ser Gly Arg Val Ser Tyr Ala Leu Gly Leu Glu Gly 
145                 150                 155                 160 


Pro Gly Val Thr Val Asp Thr Ala Cys Ser Ser Ser Leu Val Ala Leu 
                165                 170                 175     


His Leu Ala Ser Gln Ala Leu Arg Gln Arg Glu Cys Ser Leu Ala Leu 
            180                 185                 190         


Val Ser Gly Val Ser Val Met Ser Ser Pro Ala Met Phe Val Glu Phe 
        195                 200                 205             


Ser Arg Gln Arg Gly Leu Ser Ser Asp Gly Arg Cys Lys Ser Phe Ala 
    210                 215                 220                 


Ala Ser Ala Asp Gly Thr Ile Trp Ser Glu Gly Val Gly Val Leu Val 
225                 230                 235                 240 


Val Glu Arg Leu Ser Asp Ala Arg Arg Leu Gly His Arg Phe Leu Ala 
                245                 250                 255     


Val Val Arg Gly Ser Ala Val Asn Ser Asp Gly Ala Ser Asn Gly Leu 
            260                 265                 270         


Thr Ala Pro Asn Gly Ala Ser Gln Gln Arg Val Ile Arg Gln Ala Leu 
        275                 280                 285             


Ala Gly Ala Gly Leu Thr Ala Ser Asp Val Asp Val Val Glu Ala His 
    290                 295                 300                 


Gly Thr Gly Thr Lys Leu Gly Asp Pro Ile Glu Ala Glu Ala Ile Leu 
305                 310                 315                 320 


Ala Thr Tyr Gly Gln Glu Arg Ser Thr Pro Ala Trp Leu Gly Ser Leu 
                325                 330                 335     


Lys Ser Asn Ile Gly His Thr Met Ala Ala Ser Gly Val Leu Gly Val 
            340                 345                 350         


Ile Lys Met Val Glu Ala Met Arg His Gly Ser Leu Pro Arg Thr Leu 
        355                 360                 365             


His Val Asp Asp Pro Ser Pro His Val Asp Trp Thr Ser Gly Ser Val 
    370                 375                 380                 


Ala Leu Leu Thr Glu His Gln Pro Trp Pro Asp Asp Ala Lys Pro Arg 
385                 390                 395                 400 


Arg Ala Gly Val Ser Ser Phe Gly Leu Ser Gly Thr Asn Ala His Val 
                405                 410                 415     


Val Leu Glu Gln Tyr Gln Ala Pro Ala Pro Ser Val Thr Pro Val Thr 
            420                 425                 430         


Pro Val Thr Pro Val Thr Pro Val Thr Pro Asn Glu Pro Arg Pro Leu 
        435                 440                 445             


Ala Trp Val Leu Ser Ala Gln Ser Pro Lys Ala Leu Arg Glu Gln Ala 
    450                 455                 460                 


Gly Arg Leu Tyr Ala Ser Leu Ala Glu Ala Pro Glu Trp Asn Ser Leu 
465                 470                 475                 480 


Asp Ile Gly Tyr Ser Leu Ala Thr Thr Arg Ser Asp Phe Ala His Arg 
                485                 490                 495     


Ala Val Ala Val Gly Ser Gly Arg Glu Phe Leu Arg Ala Leu Ser Lys 
            500                 505                 510         


Leu Ala Asp Gly Ala Ser Trp Pro Gly Leu Thr Thr Ala Thr Ala Lys 
        515                 520                 525             


Ala Arg Arg Val Ala Phe Leu Phe Asp Gly Gln Gly Ala Gln Arg Leu 
    530                 535                 540                 


Gly Met Gly Lys Glu Leu Tyr Asp Ser Ser Pro Val Phe Ala Arg Ala 
545                 550                 555                 560 


Trp Asp Thr Val Ser Ala Gly Phe Asp Lys His Leu Asp His Ser Leu 
                565                 570                 575     


Thr Asp Val Tyr Phe Gly Glu Gly Gly Ser Thr Thr Ala Glu Leu Val 
            580                 585                 590         


Asp Asp Thr Leu Tyr Ala Gln Ala Gly Ile Phe Ala Met Glu Val Ala 
        595                 600                 605             


Leu Phe Gly Leu Leu Glu Asp Trp Gly Val Arg Pro Asp Phe Val Ala 
    610                 615                 620                 


Gly His Ser Ile Gly Glu Ala Thr Ala Ala Tyr Ala Ser Gly Met Leu 
625                 630                 635                 640 


Ser Leu Glu His Val Thr Thr Leu Ile Val Ala Arg Gly Arg Ala Leu 
                645                 650                 655     


Arg Ala Thr Pro Pro Gly Ala Met Val Ala Leu Arg Ala Gly Glu Glu 
            660                 665                 670         


Glu Val Arg Ala Phe Leu Asp Gln Thr Gly Ala Ala Leu Asp Leu Ala 
        675                 680                 685             


Ala Val Asn Ser Pro Glu Ala Val Val Val Ala Gly Glu Pro Asp Ala 
    690                 695                 700                 


Val Ala Gly Phe Glu Ala Ala Trp Ala Ala Ser Gly Arg Glu Ala Arg 
705                 710                 715                 720 


Lys Leu Arg Val Arg His Ala Phe His Ser Arg His Val Glu Ala Val 
                725                 730                 735     


Leu Asp Glu Phe Arg Thr Thr Leu Glu Ser Leu Lys Phe Ser Ala Pro 
            740                 745                 750         


Ala Leu Pro Val Val Ser Thr Val Thr Gly Gln Leu Ile Glu Pro Asp 
        755                 760                 765             


Glu Met Gly Thr Pro Glu Tyr Trp Leu Arg Gln Val Arg Gln Pro Val 
    770                 775                 780                 


Arg Phe Gln Asp Ala Val Arg Glu Leu Ala Glu Ala Gly Val Gly Thr 
785                 790                 795                 800 


Phe Val Glu Ile Gly Pro Ser Gly Ala Leu Ala Ser Ala Gly Met Glu 
                805                 810                 815     


Cys Leu Gly Gly Asp Ala Ser Phe His Ala Val Leu Arg Pro Arg Ser 
            820                 825                 830         


Pro Glu Asp Val Cys Leu Met Thr Ala Ile Ala Glu Leu Tyr Ala Gly 
        835                 840                 845             


Gly Thr Ala Ile Asp Trp Ala Lys Val Leu Ser Gly Gly Arg Ala Val 
    850                 855                 860                 


Asp Leu Pro Val Tyr Pro Phe Gln His Gln Ser Tyr Trp Leu Ala Pro 
865                 870                 875                 880 


Ala Glu Pro Ser Tyr Ala Asp Glu Pro Arg Thr Met Leu Glu Leu Val 
                885                 890                 895     


His Met Glu Val Ala Ser Val Leu Gly Met Thr Asp Pro Gly Val Ile 
            900                 905                 910         


Leu Asp Asp Ser Ser Phe Leu Glu Leu Gly Phe Asp Ser Leu Ser Ala 
        915                 920                 925             


Val Arg Leu Arg Asn Arg Leu Ser Lys Ala Thr Gly Leu Asp Leu Pro 
    930                 935                 940                 


Ser Thr Leu Leu Phe Glu His Pro Thr Ser Ala Glu Leu Ala Ser His 
945                 950                 955                 960 


Leu Asp 
        


<210>  34
<211>  934
<212>  PRT
<213>  Streptomyces violaceusniger

<400>  34

Glu Pro Leu Ala Ile Val Gly Met Ala Cys Arg Leu Pro Gly Gly Val 
1               5                   10                  15      


Ser Ser Pro Glu Asp Leu Trp Arg Leu Val Glu Ser Gly Thr Asp Ala 
            20                  25                  30          


Ile Ser Gly Phe Pro Thr Asp Arg Gly Trp Asp Val Glu Gly Leu Phe 
        35                  40                  45              


Asp Pro Asp Pro Asp Ala Ser Gly Lys Ser Tyr Cys Val Arg Gly Gly 
    50                  55                  60                  


Phe Leu Asp Ser Val Gly Gly Phe Asp Ala Ser Phe Phe Gly Ile Ser 
65                  70                  75                  80  


Pro Arg Glu Ala Leu Ala Met Asp Pro Gln Gln Arg Leu Leu Leu Glu 
                85                  90                  95      


Val Ser Trp Glu Ala Phe Glu Arg Ala Gly Ile Glu Pro Gly Ser Val 
            100                 105                 110         


Arg Gly Ser Asp Thr Gly Val Phe Met Gly Gly Phe Pro Gly Gly Tyr 
        115                 120                 125             


Gly Ala Gly Ala Asp Leu Glu Gly Phe Gly Ala Thr Ala Gly Ala Ala 
    130                 135                 140                 


Ser Val Leu Ser Gly Arg Val Ser Tyr Phe Phe Gly Leu Glu Gly Pro 
145                 150                 155                 160 


Ala Ile Thr Val Asp Thr Ala Cys Ser Ser Ser Leu Val Ala Leu His 
                165                 170                 175     


Gln Ala Gly Tyr Ala Leu Arg Gln Gly Glu Cys Ser Leu Ala Leu Val 
            180                 185                 190         


Gly Gly Val Thr Val Met Ala Thr Pro Gln Ser Phe Val Glu Phe Ser 
        195                 200                 205             


Arg Gln Arg Gly Leu Ala Ser Asp Gly Arg Cys Lys Ala Phe Ala Asp 
    210                 215                 220                 


Ala Ala Asp Gly Thr Gly Trp Ala Glu Gly Val Gly Val Leu Leu Val 
225                 230                 235                 240 


Glu Arg Leu Ser Asp Ala Gln Ala Lys Gly His Gln Val Leu Gly Val 
                245                 250                 255     


Val Arg Gly Ser Ala Val Asn Gln Asp Gly Ala Ser Asn Gly Leu Ser 
            260                 265                 270         


Ala Pro Asn Gly Pro Ser Gln Gln Arg Val Ile Arg Ala Ala Leu Ser 
        275                 280                 285             


Asn Ala Gly Leu Thr Thr Ala Glu Val Asp Val Val Glu Ala His Gly 
    290                 295                 300                 


Thr Gly Thr Thr Leu Gly Asp Pro Ile Glu Ala Gln Ala Val Leu Ala 
305                 310                 315                 320 


Thr Tyr Gly Gln Asp Arg Glu Gln Pro Leu Leu Leu Gly Ser Leu Lys 
                325                 330                 335     


Ser Asn Ile Gly His Ala Gln Ala Ala Ala Gly Val Ser Gly Val Ile 
            340                 345                 350         


Lys Met Val Met Ala Leu Arg His Gly Leu Val Pro Arg Thr Leu His 
        355                 360                 365             


Val Asp Glu Pro Ser Arg His Val Asp Trp Ser Ala Gly Ala Val Glu 
    370                 375                 380                 


Leu Val Thr Glu Asn Gln Ser Trp Pro Val Thr Gly Arg Pro Arg Arg 
385                 390                 395                 400 


Ala Gly Val Ser Ala Phe Gly Val Ser Gly Thr Asn Ala His Val Ile 
                405                 410                 415     


Leu Glu Ser Ala Pro Ala Gln Ala Ser Glu Glu Ala Gln Pro Val Val 
            420                 425                 430         


Thr Pro Val Val Thr Pro Val Val Ala Ser Glu Leu Val Pro Leu Val 
        435                 440                 445             


Val Ser Ala Lys Thr Glu Ser Ala Leu Ala Glu Val Glu Gly Arg Leu 
    450                 455                 460                 


Arg Ala Tyr Leu Ala Val Ser Pro Gly Val Asp Leu Arg Ala Val Gly 
465                 470                 475                 480 


Ser Thr Leu Ala Val Ala Arg Ser Val Phe Glu His Arg Ala Val Leu 
                485                 490                 495     


Leu Gly Asp Asp Thr Val Thr Gly Thr Val Thr Gly Thr Ala Val Ser 
            500                 505                 510         


Asp Pro Arg Val Val Phe Val Phe Pro Gly Gln Gly Trp Gln Trp Leu 
        515                 520                 525             


Gly Met Gly Ser Ala Leu Arg Gly Ala Ser Val Val Phe Ala Glu Arg 
    530                 535                 540                 


Met Ala Glu Cys Ala Ala Ala Leu Gly Glu Phe Val Asp Trp Asp Leu 
545                 550                 555                 560 


Phe Ala Val Leu Asp Asp Pro Ala Val Val Asp Arg Val Asp Val Val 
                565                 570                 575     


Gln Pro Ala Ser Trp Ala Val Met Val Ser Leu Ala Ala Val Trp Glu 
            580                 585                 590         


Ala Ala Gly Val Arg Pro Asp Ala Val Val Gly His Ser Gln Gly Glu 
        595                 600                 605             


Ile Ala Ala Ala Cys Val Ala Gly Ala Val Ser Leu Arg Asp Ala Ala 
    610                 615                 620                 


Arg Ile Val Thr Leu Arg Ser Gln Val Ile Ala Gly Leu Ala Gly Arg 
625                 630                 635                 640 


Gly Ala Met Ala Ser Val Ala Leu Pro Ala His Glu Ile Glu Leu Val 
                645                 650                 655     


Glu Gly Ala Trp Ile Ala Ala Cys Asn Gly Pro Ala Ser Thr Val Ile 
            660                 665                 670         


Ala Gly Glu Pro Asp Ala Val Asp Arg Val Leu Ala Val His Glu Ala 
        675                 680                 685             


Arg Gly Val Arg Val Arg Arg Ile Thr Val Asp Tyr Ala Ser His Thr 
    690                 695                 700                 


Pro His Val Glu Leu Ile Arg Asp Glu Leu Leu Asn Ile Thr Ala Gly 
705                 710                 715                 720 


Ile Gly Ser Gln Ala Pro Val Val Pro Trp Leu Ser Thr Val Asp Gly 
                725                 730                 735     


Thr Trp Val Glu Gly Pro Leu Asp Ala Glu Tyr Trp Tyr Arg Asn Leu 
            740                 745                 750         


Arg Glu Pro Val Gly Phe Asp Ser Ala Val Gly Glu Leu Arg Ala Gln 
        755                 760                 765             


Gly Asp Thr Val Phe Val Glu Val Ser Ala Ser Pro Val Leu Leu Gln 
    770                 775                 780                 


Ala Met Asp Asp Asp Val Val Ser Val Ala Thr Leu Arg Arg Asp Asp 
785                 790                 795                 800 


Gly Gly Ala Ala Arg Met Leu Thr Ala Leu Ala Gln Ala Phe Val Glu 
                805                 810                 815     


Gly Val Thr Val Asp Trp Pro Ala Val Leu Gly Asn Ala Pro Gly Arg 
            820                 825                 830         


Val Leu Asp Leu Pro Thr Tyr Ala Phe Glu His Gln Arg Tyr Trp Leu 
        835                 840                 845             


Lys Ser Arg Trp Leu Ala Arg Leu Ala Pro Val Glu Arg Glu Lys Ala 
    850                 855                 860                 


Leu Leu Lys Val Val Cys Asp Gly Ala Ala Thr Val Leu Gly His Ala 
865                 870                 875                 880 


Asp Ala Ser Thr Ile Pro Ala Ala Gly Ala Phe Arg Asp Leu Gly Val 
                885                 890                 895     


Asp Ser Leu Thr Ala Val Glu Leu Arg Asn Arg Leu Ala Lys Ala Thr 
            900                 905                 910         


Gly Leu Arg Leu Pro Ala Thr Leu Val Phe Asp Tyr Pro Thr Pro Thr 
        915                 920                 925             


Ala Leu Ala Ala Arg Leu 
    930                 


<210>  35
<211>  893
<212>  PRT
<213>  Streptomyces violaceusniger

<400>  35

Glu Pro Leu Ala Ile Val Gly Met Ala Cys Arg Leu Pro Gly Gly Val 
1               5                   10                  15      


Ser Ser Pro Glu Asp Leu Trp Arg Leu Val Glu Ser Gly Thr Asp Ala 
            20                  25                  30          


Val Ser Gly Phe Pro Thr Asp Arg Gly Trp Asp Val Glu Asp Leu Phe 
        35                  40                  45              


Gly Pro Ala Ala Gly Asp Ser Tyr Arg Leu Arg Gly Gly Phe Leu Asp 
    50                  55                  60                  


Ala Ala Gly Gly Phe Asp Ala Ser Phe Phe Gly Ile Ser Pro Arg Glu 
65                  70                  75                  80  


Ala Leu Ala Met Asp Pro Gln Gln Arg Leu Val Leu Glu Val Ser Trp 
                85                  90                  95      


Glu Ala Phe Glu Arg Ala Gly Ile Glu Pro Gly Ser Val Arg Gly Thr 
            100                 105                 110         


Asp Thr Gly Val Phe Met Gly Ala Tyr Pro Gly Gly Tyr Gly Ile Gly 
        115                 120                 125             


Ala Asp Leu Gly Gly Phe Gly Thr Thr Ala Gly Ala Val Ser Val Leu 
    130                 135                 140                 


Ser Gly Arg Val Ser Tyr Phe Phe Gly Leu Glu Gly Pro Ala Phe Thr 
145                 150                 155                 160 


Val Asp Thr Ala Cys Ser Ser Ser Leu Val Ala Leu His Gln Ala Gly 
                165                 170                 175     


Tyr Ala Leu Arg Gln Gly Glu Cys Ser Leu Ala Leu Val Gly Gly Val 
            180                 185                 190         


Thr Val Met Ala Thr Pro Gln Thr Phe Ala Glu Phe Ala Arg Gln Gly 
        195                 200                 205             


Gly Leu Ala Gly Asp Gly Arg Ser Lys Ala Phe Ala Asp Ser Ala Asp 
    210                 215                 220                 


Gly Ala Gly Phe Ser Glu Gly Val Gly Val Leu Leu Val Glu Arg Leu 
225                 230                 235                 240 


Ser Asp Ala Arg Arg Asn Gly His Gln Val Leu Ala Val Val Arg Gly 
                245                 250                 255     


Ser Ala Val Asn Gln Asp Gly Ala Ser Asn Gly Leu Thr Ala Pro Asn 
            260                 265                 270         


Gly Pro Ser Gln Gln Arg Val Ile Gln Ala Ala Leu Asn Asn Ala Gly 
        275                 280                 285             


Leu Thr Thr Ala Glu Val Asp Val Val Glu Ala His Gly Thr Gly Thr 
    290                 295                 300                 


Thr Leu Gly Asp Pro Ile Glu Ala Gln Ala Leu Leu Ala Ala Tyr Gly 
305                 310                 315                 320 


Gln Asp Arg Glu Arg Pro Leu Leu Leu Gly Ser Val Lys Ser Asn Leu 
                325                 330                 335     


Gly His Thr Gln Ala Ala Ala Gly Val Ser Gly Val Ile Lys Met Val 
            340                 345                 350         


Met Ala Leu Arg His Gly Leu Val Pro Arg Thr Leu His Val Asp Glu 
        355                 360                 365             


Pro Ser Arg His Val Asp Trp Ser Glu Gly Ala Val Glu Leu Val Thr 
    370                 375                 380                 


Glu Asn Gln Ser Trp Pro Asp Thr Gly Arg Pro Gly Arg Ala Gly Val 
385                 390                 395                 400 


Ser Ser Phe Gly Ile Ser Gly Thr Asn Ala His Val Ile Leu Glu Ser 
                405                 410                 415     


Ala Pro Ser Ala Gln Thr Val Glu Asn Thr Val Val Glu Ser Ala Pro 
            420                 425                 430         


Glu Trp Val Pro Leu Val Met Ser Ala Arg Thr Gln Ser Ala Leu Ala 
        435                 440                 445             


Asp Tyr Glu Gly Arg Leu Arg Ala Tyr Leu Ala Gly Ser Pro Gly Val 
    450                 455                 460                 


Asp Leu Arg Ala Val Ala Ser Thr Leu Ala Val Thr Arg Ser Val Phe 
465                 470                 475                 480 


Glu His Arg Ala Val Leu Met Gly Asp Asp Thr Val Thr Gly Ser Ala 
                485                 490                 495     


Val Ser Asp Pro Arg Val Val Phe Val Phe Pro Gly Gln Gly Ser Gln 
            500                 505                 510         


Arg Ala Gly Met Gly Glu Glu Leu Ala Ala Ala Phe Pro Val Phe Ala 
        515                 520                 525             


Gln Ile His Gln Gln Val Trp Asp Leu Leu Asp Val Pro Asp Leu Asp 
    530                 535                 540                 


Val Asn Glu Thr Gly Tyr Ala Gln Pro Ala Leu Phe Ala Leu Gln Val 
545                 550                 555                 560 


Ala Leu Phe Gly Leu Leu Glu Ser Trp Gly Val Gly Pro Asp Ala Val 
                565                 570                 575     


Val Gly His Ser Val Gly Glu Leu Ala Ala Ala Tyr Ala Ser Gly Val 
            580                 585                 590         


Trp Ser Leu Glu Asp Ala Cys Thr Leu Val Ser Ala Arg Ala Arg Leu 
        595                 600                 605             


Met Gln Ala Leu Pro Ala Gly Gly Val Met Val Ala Val Pro Val Ser 
    610                 615                 620                 


Glu Asp Glu Ala Arg Ala Val Leu Gly Glu Gly Val Glu Ile Ala Ala 
625                 630                 635                 640 


Val Asn Gly Pro Ser Ser Val Val Leu Ser Gly Asp Glu Ala Ala Val 
                645                 650                 655     


Leu Arg Ala Ala Ala Gly Leu Gly Lys Trp Thr Arg Leu Ala Thr Ser 
            660                 665                 670         


His Ala Phe His Ser Ala Arg Met Glu Pro Met Leu Glu Glu Phe Arg 
        675                 680                 685             


Ala Val Ala Glu Arg Leu Thr Tyr Gln Thr Pro His Leu Thr Met Ala 
    690                 695                 700                 


Ala Gly Glu Gln Val Thr Thr Pro Asp Tyr Trp Val Arg Gln Val Arg 
705                 710                 715                 720 


Asp Val Val Arg Phe Gly Glu Gln Val Ala Ser Phe Glu Asp Ala Val 
                725                 730                 735     


Phe Leu Glu Leu Gly Ala Asp Arg Ser Leu Ala Arg Leu Val Asp Gly 
            740                 745                 750         


Ile Ala Met Leu His Gly Asp His Glu Ala Gln Asp Ala Ile Ser Ala 
        755                 760                 765             


Met Ala His Leu Tyr Val Ser Gly Val Ala Val Asp Trp Pro Ala Val 
    770                 775                 780                 


Leu Gly Asp Val Arg Gly Arg Val Leu Asp Leu Pro Thr Tyr Ala Phe 
785                 790                 795                 800 


Gln His Glu Arg Tyr Trp Leu Glu Gly Arg Trp Leu Ala Ala Leu Ala 
                805                 810                 815     


Pro Ala Glu Arg Glu Lys Ala Leu Leu Lys Leu Val Ser Asp Gly Ala 
            820                 825                 830         


Ala Thr Val Leu Gly His Ala Asp Ala Ser Thr Val Pro Val Ser Ala 
        835                 840                 845             


Val Phe Arg Asp Leu Gly Val Asp Ser Leu Thr Ala Val Glu Leu Arg 
    850                 855                 860                 


Asn Arg Leu Ala Lys Ala Thr Gly Leu Arg Leu Pro Ala Thr Leu Val 
865                 870                 875                 880 


Phe Asp Tyr Pro Thr Pro Thr Ala Leu Ala Ala Arg Leu 
                885                 890             


<210>  36
<211>  922
<212>  PRT
<213>  Streptomyces violaceusniger

<400>  36

Glu Pro Leu Ala Ile Val Gly Met Ala Cys Arg Leu Pro Gly Gly Val 
1               5                   10                  15      


Ala Ser Pro Glu Asp Leu Trp Arg Leu Val Glu Ser Gly Thr Asp Ala 
            20                  25                  30          


Val Ser Gly Phe Pro Thr Asp Arg Gly Trp Asp Val Glu Asp Phe Asp 
        35                  40                  45              


Ser Ala Gly Lys Ser Tyr Arg Ala Glu Gly Gly Phe Leu Asp Ala Ala 
    50                  55                  60                  


Ala Gly Phe Asp Ala Ser Phe Phe Gly Ile Ser Pro Arg Glu Ala Leu 
65                  70                  75                  80  


Ala Met Asp Pro Gln Gln Arg Leu Leu Leu Glu Val Ser Trp Glu Thr 
                85                  90                  95      


Phe Glu Arg Ala Gly Ile Glu Pro Gly Ser Val Arg Gly Thr Asp Thr 
            100                 105                 110         


Gly Val Phe Met Gly Ala Tyr Pro Gly Gly Tyr Gly Ile Gly Ala Asp 
        115                 120                 125             


Leu Gly Gly Phe Gly Ala Thr Ala Gly Ala Thr Ser Val Leu Ser Gly 
    130                 135                 140                 


Arg Val Ser Tyr Phe Phe Gly Leu Glu Gly Pro Ala Phe Thr Val Asp 
145                 150                 155                 160 


Thr Ala Cys Ser Ser Ser Leu Val Ala Leu His Gln Ala Gly Tyr Ala 
                165                 170                 175     


Leu Arg Gln Gly Glu Cys Ser Met Ala Leu Val Gly Gly Ala Thr Val 
            180                 185                 190         


Met Ala Thr Pro Glu Leu Phe Thr Glu Phe Ser Arg Gln Gly Gly Leu 
        195                 200                 205             


Ala Ser Asp Gly Arg Cys Lys Ala Phe Ala Asp Ser Ala Asp Gly Thr 
    210                 215                 220                 


Gly Trp Ala Glu Gly Val Gly Val Leu Leu Val Glu Arg Leu Ser Asp 
225                 230                 235                 240 


Ala Gln Ala Lys Gly His Gln Val Leu Ala Val Val Arg Ser Ser Ala 
                245                 250                 255     


Val Asn Gln Asp Gly Ala Ser Asn Gly Leu Thr Ala Pro Asn Gly Pro 
            260                 265                 270         


Ser Gln Gln Arg Val Ile Gln Ala Ala Leu Ser Asn Ala Gly Leu Ala 
        275                 280                 285             


Ala Tyr Glu Val Asp Val Val Glu Ala His Gly Thr Gly Thr Thr Leu 
    290                 295                 300                 


Gly Asp Pro Ile Glu Ala Gln Ala Val Leu Ala Thr Tyr Gly Gln Asp 
305                 310                 315                 320 


Arg Glu Arg Pro Leu Leu Leu Gly Ser Leu Lys Ser Asn Ile Gly His 
                325                 330                 335     


Thr Gln Ala Ala Ser Gly Val Ser Gly Val Ile Lys Met Val Met Ala 
            340                 345                 350         


Leu Gln Arg Gly Leu Val Pro Arg Thr Leu His Val Asp Glu Pro Ser 
        355                 360                 365             


Arg His Val Asp Trp Ser Ala Gly Ala Val Glu Leu Val Arg Glu Asn 
    370                 375                 380                 


Gln Ser Trp Pro Asp Thr Glu Gly Pro Arg Arg Ala Gly Val Ser Ser 
385                 390                 395                 400 


Phe Gly Val Ser Gly Thr Asn Ala His Val Ile Leu Glu Ser Ala Pro 
                405                 410                 415     


Ala Gln Pro Ala Glu Glu Ala Gln Pro Val Val Thr Pro Val Val Ala 
            420                 425                 430         


Ser Glu Leu Val Pro Leu Val Val Ser Ala Lys Ser Gln Ser Ala Leu 
        435                 440                 445             


Thr Glu Ala Glu Gly Arg Leu Arg Ala Tyr Leu Ala Ala Ser Pro Gly 
    450                 455                 460                 


Val Asp Thr Arg Ala Val Gly Ala Thr Leu Ala Val Ala Arg Ser Val 
465                 470                 475                 480 


Phe Glu His Arg Ala Val Leu Leu Gly Asp Asp Thr Val Thr Gly Thr 
                485                 490                 495     


Gly Thr Ala Met Ser Asp Pro Arg Val Val Phe Val Phe Pro Gly Gln 
            500                 505                 510         


Gly Trp Gln Trp Leu Gly Met Gly Ser Ala Leu Arg Asp Ser Ser Val 
        515                 520                 525             


Val Phe Ala Glu Arg Met Ala Glu Cys Ala Ala Ala Leu Ser Asp Phe 
    530                 535                 540                 


Val Asp Trp Asp Leu Phe Thr Val Leu Asp Asp Pro Ala Val Val Asp 
545                 550                 555                 560 


Arg Val Asp Val Val Gln Pro Ala Ser Trp Ala Val Met Val Ser Leu 
                565                 570                 575     


Ala Ala Val Trp Glu Ala Ala Gly Val Arg Pro Asp Ala Val Ile Gly 
            580                 585                 590         


His Ser Gln Gly Glu Ile Ala Ala Ala Cys Ile Ala Gly Ala Leu Ser 
        595                 600                 605             


Leu Arg Asp Ala Ala Arg Ile Val Ser Leu Arg Ser Gln Val Ile Ala 
    610                 615                 620                 


Gly Leu Ala Gly Arg Gly Ala Met Ala Ser Ile Ala Leu Pro Ala Gln 
625                 630                 635                 640 


Asp Val Glu Leu Ala Glu Gly Ala Trp Ile Ala Ala His Asn Gly Pro 
                645                 650                 655     


Ala Ser Thr Val Ile Ala Gly Ala Pro Glu Ala Val Asp Arg Val Leu 
            660                 665                 670         


Ala Val His Glu Ala Arg Gly Val Arg Val Arg Arg Ile Thr Val Asp 
        675                 680                 685             


Tyr Ala Ser His Thr Pro His Val Glu Leu Ile Arg Asp Glu Leu Leu 
    690                 695                 700                 


His Ile Thr Ala Gly Ile Gly Ser Gln Ala Pro Val Val Pro Trp Leu 
705                 710                 715                 720 


Ser Thr Val Asp Gly Thr Trp Val Glu Gly Pro Leu Asp Ala Glu Tyr 
                725                 730                 735     


Trp Tyr Arg Asn Leu Arg Glu Pro Val Gly Phe Ala Pro Ala Ile Arg 
            740                 745                 750         


Gln Leu Gln Asp Gln Gly Glu Thr Val Phe Ile Glu Val Ser Ala Ser 
        755                 760                 765             


Pro Val Leu Leu Gln Ala Met Asp Asp Asp Val Val Ser Val Ala Thr 
    770                 775                 780                 


Leu Arg Arg Asp Asp Gly Gly Ala Ala Arg Met Val Thr Ala Leu Ala 
785                 790                 795                 800 


Gln Ala Tyr Val Gln Gly Val Thr Val Asp Trp Pro Ala Val Leu Gly 
                805                 810                 815     


Asn Val Pro Gly Arg Val Leu Asp Leu Pro Thr Tyr Ala Phe Glu His 
            820                 825                 830         


Gln Arg Tyr Trp Leu Lys Ser Trp Leu Ala Ala Leu Ala Pro Ala Glu 
        835                 840                 845             


Arg Glu Lys Ala Leu Leu Lys Val Val Cys Asp Ser Ala Ala Val Val 
    850                 855                 860                 


Leu Gly His Ala Asp Ala Arg Ser Ile Pro Ala Ala Gly Ala Phe Lys 
865                 870                 875                 880 


Asp Leu Gly Val Asp Ser Leu Met Ala Val Glu Leu Arg Asn Arg Leu 
                885                 890                 895     


Val Lys Ala Thr Gly Leu Arg Leu Pro Ala Thr Leu Val Phe Asp Tyr 
            900                 905                 910         


Pro Thr Pro Ala Ala Leu Ala Ala Arg Leu 
        915                 920         


<210>  37
<211>  925
<212>  PRT
<213>  Streptomyces violaceusniger

<400>  37

Glu Pro Leu Ala Ile Val Gly Met Ala Cys Arg Leu Pro Gly Gly Val 
1               5                   10                  15      


Ser Ser Pro Glu Asp Leu Trp Arg Leu Val Glu Ser Gly Thr Asp Ala 
            20                  25                  30          


Val Ser Gly Phe Pro Thr Asp Arg Gly Trp Asp Leu Glu Asp Leu Phe 
        35                  40                  45              


Asp Pro Asp Pro Glu Ala Ala Gly Lys Ser Tyr Cys Val Gln Gly Gly 
    50                  55                  60                  


Phe Leu Asp Ala Ala Ala Gly Phe Asp Ala Gly Phe Phe Gly Ile Ser 
65                  70                  75                  80  


Pro Arg Glu Ala Leu Ala Met Asp Pro Gln Gln Arg Leu Leu Leu Glu 
                85                  90                  95      


Val Ser Trp Glu Ala Phe Glu Arg Ala Gly Ile Glu Pro Gly Ser Val 
            100                 105                 110         


Arg Gly Ser Asp Thr Gly Val Phe Ile Gly Ala Phe Pro Val Gly Tyr 
        115                 120                 125             


Gly Val Gly Phe Asp Arg Glu Gly Tyr Gly Ala Thr Ser Gly Pro Ser 
    130                 135                 140                 


Val Leu Ser Gly Arg Val Ser Tyr Phe Phe Gly Leu Glu Gly Pro Ala 
145                 150                 155                 160 


Ile Thr Met Asp Thr Ala Cys Ser Ser Ser Leu Val Ala Leu His Leu 
                165                 170                 175     


Ala Ala Gln Ala Leu Arg Asn Gly Glu Cys Ser Met Ala Leu Ala Gly 
            180                 185                 190         


Gly Val Thr Val Met Ala Thr Pro Glu Val Phe Thr Glu Phe Ala Arg 
        195                 200                 205             


Gln Arg Gly Leu Ala Ser Asp Gly Arg Cys Lys Ala Phe Ala Asp Ser 
    210                 215                 220                 


Ala Asp Gly Ala Gly Phe Ser Glu Gly Ala Gly Leu Leu Leu Val Glu 
225                 230                 235                 240 


Arg Leu Ser Asp Ala Arg Arg Asn Gly His Gln Val Leu Ala Val Val 
                245                 250                 255     


Arg Gly Ser Ala Val Asn Gln Asp Gly Ala Ser Asn Gly Leu Thr Ala 
            260                 265                 270         


Pro Asn Gly Pro Ser Gln Gln Arg Val Ile Gln Ala Ala Leu Ile Asn 
        275                 280                 285             


Ala Gly Leu Thr Thr Ala Glu Val Asp Val Val Glu Ala His Gly Thr 
    290                 295                 300                 


Gly Thr Thr Leu Gly Asp Pro Ile Glu Ala Gln Ala Val Leu Ala Thr 
305                 310                 315                 320 


Tyr Gly Gln Gly Arg Glu Arg Pro Leu Leu Leu Gly Ser Leu Lys Ser 
                325                 330                 335     


Asn Ile Gly His Thr Gln Ala Ala Ser Gly Val Ser Gly Val Ile Lys 
            340                 345                 350         


Met Val Met Ala Leu Gln Arg Gly Leu Val Pro Arg Thr Leu His Val 
        355                 360                 365             


Asp Glu Pro Ser Arg His Val Asp Trp Ser Ala Gly Ala Val Glu Leu 
    370                 375                 380                 


Val Arg Glu Asn Gln Ser Trp Pro Asp Ser Glu Gly Pro Arg Arg Ala 
385                 390                 395                 400 


Gly Val Ser Ser Phe Gly Val Ser Gly Thr Asn Ala His Val Ile Leu 
                405                 410                 415     


Glu Ser Ala Pro Ala Gln Pro Ala Glu Glu Ala Gln Pro Val Val Thr 
            420                 425                 430         


Pro Val Val Ala Ser Glu Leu Val Pro Leu Val Val Ser Ala Lys Thr 
        435                 440                 445             


Glu Ser Ala Leu Thr Glu Val Glu Gly Arg Leu Arg Val Tyr Leu Ala 
    450                 455                 460                 


Ala Ser Pro Gly Val Asp Thr Arg Ala Val Ala Ser Thr Leu Ala Val 
465                 470                 475                 480 


Thr Arg Ser Val Phe Glu His Arg Ala Val Leu Leu Gly Asp Asp Thr 
                485                 490                 495     


Val Thr Gly Thr Gly Thr Ala Val Ser Asp Pro Arg Val Val Phe Val 
            500                 505                 510         


Phe Pro Gly Gln Gly Trp Gln Trp Leu Gly Met Gly Ser Ala Leu Arg 
        515                 520                 525             


Asp Ser Ser Val Val Phe Ala Glu Arg Met Ala Glu Cys Ala Ala Ala 
    530                 535                 540                 


Leu Ser Glu Phe Val Asp Trp Asp Leu Phe Ala Val Leu Asp Asp Pro 
545                 550                 555                 560 


Ala Val Val Asp Arg Val Asp Val Val Gln Pro Ala Ser Trp Ala Val 
                565                 570                 575     


Met Val Ser Leu Ala Ala Val Trp Gln Ala Ala Gly Val Arg Pro Asp 
            580                 585                 590         


Ala Val Ile Gly His Ser Gln Gly Glu Ile Ala Ala Ala Cys Val Ala 
        595                 600                 605             


Gly Val Leu Ser Leu Arg Asp Ala Ala Arg Ile Val Thr Leu Arg Ser 
    610                 615                 620                 


Gln Ala Ile Ala Gly Leu Ala Gly Arg Gly Ala Met Ala Ser Ile Ala 
625                 630                 635                 640 


Leu Pro Ala Gln Asp Val Glu Leu Val Glu Gly Ala Trp Val Ala Ala 
                645                 650                 655     


His Asn Gly Pro Ala Ser Thr Val Ile Ala Gly Ala Pro Glu Ala Val 
            660                 665                 670         


Asp Arg Val Leu Ala Val His Glu Ala Arg Gly Val Arg Val Arg Arg 
        675                 680                 685             


Ile Ala Val Asp Tyr Ala Ser His Thr Pro His Val Glu Leu Ile Arg 
    690                 695                 700                 


Asp Glu Leu Leu Asp Ile Thr Ala Gly Ile Gly Ser Gln Ala Pro Val 
705                 710                 715                 720 


Val Pro Trp Leu Ser Thr Val Asp Gly Thr Trp Val Glu Gly Pro Leu 
                725                 730                 735     


Asp Ala Glu Tyr Trp Tyr Arg Asn Leu Arg Glu Pro Val Gly Phe Ala 
            740                 745                 750         


Pro Ala Val Ser Gln Leu Gln Val Gln Gly Glu Thr Val Phe Val Glu 
        755                 760                 765             


Val Ser Ala Ser Pro Val Leu Leu Gln Ala Met Asp Asp Asp Val Val 
    770                 775                 780                 


Ser Val Ala Thr Leu Arg Arg Asp Asp Gly Gly Ala Ala Arg Met Leu 
785                 790                 795                 800 


Thr Ala Leu Ala Gln Ala Tyr Thr Gln Gly Val Ala Val Asp Trp Pro 
                805                 810                 815     


Ala Val Leu Gly Thr Thr Thr Ala Gln Val Leu Asp Leu Pro Thr Tyr 
            820                 825                 830         


Ala Phe Gln His Arg Arg Tyr Trp Val Glu Trp Leu Ala Ala Leu Ala 
        835                 840                 845             


Pro Glu Glu Arg Glu Lys Ala Leu Leu Arg Val Val Cys Asp Gly Ala 
    850                 855                 860                 


Ala Thr Val Leu Gly His Ala Asp Val Gly Ser Ile Pro Val Thr Ala 
865                 870                 875                 880 


Ala Phe Lys Asp Leu Gly Val Asp Ser Leu Thr Ala Val Glu Leu Arg 
                885                 890                 895     


Asn Arg Leu Ala Lys Ala Thr Gly Leu Arg Leu Pro Ala Thr Leu Ala 
            900                 905                 910         


Phe Asp Tyr Pro Thr Pro Thr Ala Leu Ala Ala Arg Leu 
        915                 920                 925 


<210>  38
<211>  899
<212>  PRT
<213>  Streptomyces violaceusniger

<400>  38

Glu Pro Leu Ala Ile Val Gly Met Ala Cys Arg Leu Pro Gly Gly Val 
1               5                   10                  15      


Ser Ser Pro Glu Asp Leu Trp Arg Leu Val Glu Ser Gly Thr Asp Ala 
            20                  25                  30          


Ile Ser Gly Phe Pro Thr Asp Arg Gly Trp Asp Val Glu His Leu Tyr 
        35                  40                  45              


Asp Pro Asp Pro Asp Ala Pro Gly Lys Ala Tyr Cys Val Gln Gly Gly 
    50                  55                  60                  


Phe Leu Asp Ser Ala Gly Gly Phe Asp Ala Ser Phe Phe Gly Ile Ser 
65                  70                  75                  80  


Pro Arg Glu Ala Leu Ala Met Asp Pro Gln Gln Arg Leu Val Leu Glu 
                85                  90                  95      


Ala Ser Trp Glu Ala Phe Glu Arg Ala Gly Ile Glu Pro Gly Ser Leu 
            100                 105                 110         


Arg Gly Thr Asp Thr Gly Val Phe Met Gly Ala Tyr Pro Gly Gly Tyr 
        115                 120                 125             


Gly Ile Gly Ala Asp Leu Gly Gly Phe Gly Ala Thr Ala Gly Ala Val 
    130                 135                 140                 


Ser Val Leu Ser Gly Arg Val Ser Tyr Phe Phe Gly Leu Glu Gly Pro 
145                 150                 155                 160 


Ala Val Thr Val Asp Thr Ala Cys Ser Ser Ser Leu Val Ala Leu His 
                165                 170                 175     


Gln Ala Gly Tyr Ala Leu Arg Gln Gly Glu Cys Ser Leu Ala Leu Val 
            180                 185                 190         


Gly Gly Val Thr Val Met Ala Thr Pro Gln Ser Phe Val Glu Phe Ser 
        195                 200                 205             


Arg Gln Arg Gly Leu Ala Gly Asp Gly Arg Cys Lys Ala Phe Ala Asp 
    210                 215                 220                 


Ala Ala Asp Gly Thr Gly Trp Ala Glu Gly Val Gly Val Leu Leu Val 
225                 230                 235                 240 


Glu Arg Leu Ser Asp Ala Gln Ala Lys Gly His Gln Val Leu Ala Val 
                245                 250                 255     


Val Arg Gly Ser Ala Val Asn Gln Asp Gly Ala Ser Asn Gly Leu Ser 
            260                 265                 270         


Ala Pro Asn Gly Pro Ser Gln Gln Arg Val Ile Arg Gln Ala Leu Ala 
        275                 280                 285             


Asn Ala Gly Leu Thr Thr Ala Glu Val Asp Val Val Glu Ala His Gly 
    290                 295                 300                 


Thr Gly Thr Thr Leu Gly Asp Pro Ile Glu Ala Gln Ala Leu Leu Ala 
305                 310                 315                 320 


Thr Tyr Gly Gln Asp Arg Glu Arg Pro Leu Leu Leu Gly Ser Val Lys 
                325                 330                 335     


Ser Asn Leu Gly His Thr Gln Ala Ala Ala Gly Val Ser Gly Val Ile 
            340                 345                 350         


Lys Met Val Met Ala Leu Arg His Gly Leu Val Pro Arg Thr Leu His 
        355                 360                 365             


Val Asp Glu Pro Ser Arg His Val Asp Trp Ser Glu Gly Ala Val Glu 
    370                 375                 380                 


Leu Val Thr Glu Asn Gln Pro Trp Pro Asp Ala Asp Arg Pro Arg Arg 
385                 390                 395                 400 


Ala Gly Val Ser Ser Phe Gly Ile Ser Gly Thr Asn Ala His Val Ile 
                405                 410                 415     


Leu Glu Ser Ala Pro Ser Thr Gln Ala Val Asp Asp Val Arg Pro Val 
            420                 425                 430         


Glu Ala Pro Val Val Ala Ser Glu Trp Val Pro Leu Val Val Ser Ala 
        435                 440                 445             


Arg Thr Leu Pro Ala Leu Val Glu Tyr Glu Gly Arg Leu Arg Ala Tyr 
    450                 455                 460                 


Leu Ala Gly Ser Pro Gly Val Asp Met Arg Ala Val Gly Ser Thr Leu 
465                 470                 475                 480 


Ala Val Thr Arg Ser Val Phe Glu His Arg Ala Val Leu Met Gly Asp 
                485                 490                 495     


Asp Thr Val Thr Gly Ser Ala Val Ser Gly Pro Arg Val Val Phe Val 
            500                 505                 510         


Phe Pro Gly Gln Gly Ser Gln Arg Ala Gly Met Gly Glu Glu Leu Ala 
        515                 520                 525             


Ala Ala Phe Pro Val Phe Ala Arg Ile His Gln Gln Val Trp Asp Leu 
    530                 535                 540                 


Leu Asp Val Pro Asp Leu Glu Val Asn Glu Thr Gly Tyr Ala Gln Pro 
545                 550                 555                 560 


Ala Leu Phe Ala Leu Gln Val Ala Leu Phe Gly Leu Leu Glu Ser Trp 
                565                 570                 575     


Gly Val Gly Pro Asp Ala Val Ile Gly His Ser Val Gly Glu Leu Ala 
            580                 585                 590         


Ala Gly Tyr Val Ser Gly Leu Trp Ser Leu Glu Asp Ala Cys Thr Leu 
        595                 600                 605             


Val Ser Ala Arg Ala Arg Leu Met Gln Ala Leu Pro Pro Gly Gly Val 
    610                 615                 620                 


Met Val Ala Val Pro Val Ser Glu Glu Glu Ala Lys Ala Val Leu Cys 
625                 630                 635                 640 


Glu Gly Val Glu Ile Ala Ala Val Asn Gly Pro Ser Ser Val Val Leu 
                645                 650                 655     


Ser Gly Asp Glu Thr Ala Val Leu Arg Ala Ala Ala Ala Leu Gly Lys 
            660                 665                 670         


Ser Thr Arg Leu Ala Thr Ser His Ala Phe His Ser Ala Arg Met Glu 
        675                 680                 685             


Pro Met Leu Asp Glu Phe Arg Ala Val Ala Glu Arg Leu Thr Tyr Gln 
    690                 695                 700                 


Thr Pro Arg Leu Pro Met Ala Ala Gly Glu Gln Val Thr Thr Pro Asp 
705                 710                 715                 720 


Tyr Trp Val Arg Gln Val Arg Glu Pro Val Arg Phe Gly Glu Gln Ala 
                725                 730                 735     


Ala Ser Cys Gly Asp Ala Val Phe Val Glu Leu Gly Ala Asp Arg Ser 
            740                 745                 750         


Leu Ala Arg Leu Val Asp Gly Val Ala Met Leu His Gly Asp His Glu 
        755                 760                 765             


Ala Gln Ala Ala Ile Ser Ala Leu Ala His Leu Tyr Val Asn Gly Val 
    770                 775                 780                 


Thr Val Asp Trp Pro Ala Val Leu Gly Asp Val Pro Gly Arg Val Leu 
785                 790                 795                 800 


Asp Leu Pro Thr Tyr Ala Phe Gln His Gln Arg Tyr Trp Leu Glu Gly 
                805                 810                 815     


Trp Leu Ala Ala Leu Ala Pro Glu Glu Arg Ala Lys Ala Leu Leu Lys 
            820                 825                 830         


Val Val Cys Asp Thr Ala Ala Thr Val Leu Gly His Ala Asp Ala Arg 
        835                 840                 845             


Thr Ile Pro Met Thr Gly Ala Phe Arg Asp Leu Gly Ile Asp Ser Leu 
    850                 855                 860                 


Thr Ala Val Glu Leu Arg Asn Gly Leu Ala Lys Ala Thr Gly Leu Arg 
865                 870                 875                 880 


Leu Pro Ala Thr Leu Val Phe Asp Tyr Pro Thr Pro Thr Val Leu Ala 
                885                 890                 895     


Ala Arg Leu 
            


<210>  39
<211>  926
<212>  PRT
<213>  Streptomyces violaceusniger

<400>  39

Glu Pro Leu Ala Ile Val Gly Met Ala Cys Arg Leu Pro Gly Gly Val 
1               5                   10                  15      


Ser Ser Pro Glu Asp Leu Trp Arg Leu Val Glu Ser Gly Thr Asp Ala 
            20                  25                  30          


Ile Ser Gly Phe Pro Thr Asp Arg Gly Trp Asp Ala Glu Ser Leu Tyr 
        35                  40                  45              


Asp Pro Asp Pro Asp Ala Pro Gly Lys Ser Tyr Cys Val Glu Gly Gly 
    50                  55                  60                  


Phe Leu Asp Asn Ala Ala Ser Phe Asp Ala Gly Phe Phe Gly Ile Ser 
65                  70                  75                  80  


Pro Arg Glu Ala Leu Ala Met Asp Pro Gln Gln Arg Leu Val Leu Glu 
                85                  90                  95      


Val Ser Trp Glu Ala Phe Glu Arg Ala Gly Ile Glu Pro Gly Ser Val 
            100                 105                 110         


Arg Gly Thr Asp Thr Gly Val Phe Met Gly Ala Tyr Ala Gly Gly Tyr 
        115                 120                 125             


Gly Ala Gly Ala Asp Leu Gly Gly Phe Ala Ala Thr Ala Ser Ala Thr 
    130                 135                 140                 


Ser Val Leu Ser Gly Arg Val Ser Tyr Phe Phe Gly Leu Glu Gly Pro 
145                 150                 155                 160 


Ala Phe Thr Val Asp Thr Ala Cys Ser Ser Ser Leu Val Ala Leu His 
                165                 170                 175     


Gln Ala Gly Tyr Ala Leu Arg Gln Gly Glu Cys Ser Leu Ala Leu Val 
            180                 185                 190         


Gly Gly Ala Thr Val Met Ala Thr Pro Gln Ser Phe Val Glu Phe Ser 
        195                 200                 205             


Arg Gln Arg Gly Leu Ala Ser Asp Gly Arg Cys Lys Ala Phe Ala Asp 
    210                 215                 220                 


Ala Ala Asp Gly Thr Gly Trp Ala Glu Gly Val Gly Val Leu Leu Val 
225                 230                 235                 240 


Glu Arg Leu Ser Asp Ala Arg Arg Asn Gly His Gln Val Leu Ala Val 
                245                 250                 255     


Val Arg Ser Ser Ala Val Asn Gln Asp Gly Ala Ser Asn Gly Leu Ser 
            260                 265                 270         


Ala Pro Asn Gly Pro Ser Gln Gln Gly Val Ile Arg Gln Ala Leu Ala 
        275                 280                 285             


Asn Ala Gly Leu Thr Pro Ala Glu Val Asp Val Val Glu Ala His Gly 
    290                 295                 300                 


Thr Gly Thr Thr Leu Gly Asp Pro Ile Glu Ala Gln Ala Val Leu Ala 
305                 310                 315                 320 


Thr Tyr Gly Gln Asp Arg Glu Arg Pro Leu Leu Leu Gly Ser Leu Lys 
                325                 330                 335     


Ser Asn Ile Gly His Thr Gln Ala Ala Ser Gly Val Ser Gly Val Ile 
            340                 345                 350         


Lys Met Val Met Ala Leu Gln His His Thr Val Pro Arg Thr Leu His 
        355                 360                 365             


Val Asn Glu Pro Ser Arg His Val Asp Trp Ser Ala Gly Ala Val Gln 
    370                 375                 380                 


Leu Val Arg Glu Asn Gln Ser Trp Pro Glu Gly Asp Arg Pro Arg Arg 
385                 390                 395                 400 


Ala Gly Val Ser Ser Phe Gly Val Ser Gly Thr Asn Ala His Ile Ile 
                405                 410                 415     


Leu Glu Ser Ala Pro Ala Gln Ser Ala Glu Glu Val Gln Pro Val Glu 
            420                 425                 430         


Val Pro Val Val Ala Ser Asp Val Leu Pro Leu Val Val Ser Ala Lys 
        435                 440                 445             


Thr His Ser Ala Leu Thr Glu Ala Glu Asp Arg Leu Arg Ala Tyr Leu 
    450                 455                 460                 


Thr Ala Ser Pro Glu Ala Asp Met Pro Ala Val Ala Ser Thr Leu Ala 
465                 470                 475                 480 


Val Thr Arg Ser Val Phe Glu His Arg Ala Val Leu Leu Gly Asp Asp 
                485                 490                 495     


Thr Val Thr Gly Thr Gly Thr Ala Val Ser Asp Pro Arg Val Val Phe 
            500                 505                 510         


Val Phe Pro Gly Gln Gly Trp Gln Trp Leu Gly Met Gly Ser Ala Leu 
        515                 520                 525             


Arg Asp Ser Ser Val Val Phe Ala Glu Arg Met Ala Glu Cys Ala Ala 
    530                 535                 540                 


Ala Leu Ser Asp Phe Val Asp Trp Asp Leu Phe Ala Val Leu Asp Asp 
545                 550                 555                 560 


Pro Ala Val Val Asp Arg Val Asp Val Val Gln Pro Ala Ser Trp Ala 
                565                 570                 575     


Val Met Val Ser Leu Ala Ala Val Trp Gln Ala Ala Gly Val Arg Pro 
            580                 585                 590         


Asp Ala Val Ile Gly His Ser Gln Gly Glu Ile Ala Ala Ala Cys Ile 
        595                 600                 605             


Ala Gly Ala Leu Ser Leu Arg Asp Ala Ala Arg Ile Val Thr Leu Arg 
    610                 615                 620                 


Ser Gln Val Ile Ala Gly Leu Ala Gly Arg Gly Ala Met Ala Ser Ile 
625                 630                 635                 640 


Ala Leu Pro Ala Gln Glu Val Glu Leu Ala Glu Gly Ala Trp Ile Ala 
                645                 650                 655     


Ala His Asn Gly Pro Ala Ser Thr Val Ile Ala Gly Thr Pro Glu Ala 
            660                 665                 670         


Val Asp Leu Val Leu Thr Ala His Glu Ala Gln Gly Thr Arg Val Arg 
        675                 680                 685             


Arg Ile Ala Val Asp Tyr Ala Ser His Thr Pro His Val Glu Leu Ile 
    690                 695                 700                 


Arg Asp Glu Leu Leu Asp Ile Thr Ala Gly Ile Gly Ser Gln Ala Pro 
705                 710                 715                 720 


Val Val Pro Trp Leu Ser Thr Val Asp Gly Thr Trp Val Glu Gly Pro 
                725                 730                 735     


Leu Asp Ala Glu Tyr Trp Tyr Arg Asn Leu Arg Glu Pro Val Gly Phe 
            740                 745                 750         


Ala Pro Ala Val Arg Gln Leu Gln Asp Gln Gly Glu Thr Val Phe Ile 
        755                 760                 765             


Glu Val Ser Ala Ser Pro Val Leu Leu Gln Ala Met Gly Asp Asp Ala 
    770                 775                 780                 


Val Thr Val Ala Thr Leu Arg Cys Asp Asp Gly Gly Ala Ala Arg Met 
785                 790                 795                 800 


Leu Thr Ala Leu Ala Gln Ala Tyr Thr Gln Gly Val Ala Val Asp Trp 
                805                 810                 815     


Pro Ala Val Leu Gly Thr Thr Thr Ala Arg Val Leu Asp Leu Pro Thr 
            820                 825                 830         


Tyr Ala Phe Gln Arg Gln Arg Tyr Trp Val Glu Trp Leu Ala Gly Leu 
        835                 840                 845             


Ala Pro Glu Glu Arg Ala Lys Ala Leu Leu Lys Val Val Cys Asp Thr 
    850                 855                 860                 


Ala Ala Thr Val Leu Gly His Ala Asp Ala Arg Thr Ile Pro Leu Thr 
865                 870                 875                 880 


Gly Ala Phe Lys Asp Leu Gly Val Asp Ser Leu Thr Ala Val Glu Leu 
                885                 890                 895     


Arg Asn Ser Leu Thr Lys Ala Thr Gly Leu Arg Leu Pro Ala Thr Leu 
            900                 905                 910         


Val Phe Asp Tyr Pro Thr Pro Thr Ala Leu Ala Val Arg Leu 
        915                 920                 925     


<210>  40
<211>  926
<212>  PRT
<213>  Streptomyces violaceusniger

<400>  40

Glu Pro Leu Ala Ile Val Gly Met Ala Cys Arg Leu Pro Gly Gly Val 
1               5                   10                  15      


Ser Ser Pro Glu Asp Leu Trp Arg Leu Val Glu Ser Gly Thr Asp Ala 
            20                  25                  30          


Val Ser Gly Phe Pro Thr Asp Arg Gly Trp Asp Leu Glu Asp Leu Phe 
        35                  40                  45              


Asp Pro Asp Pro Glu Ala Ala Gly Lys Ser Tyr Cys Ala Glu Gly Gly 
    50                  55                  60                  


Phe Leu Asp Ala Ala Ala Gly Phe Asp Ala Gly Phe Phe Gly Ile Ser 
65                  70                  75                  80  


Pro Arg Glu Ala Leu Ala Met Asp Pro Gln Gln Arg Leu Leu Leu Glu 
                85                  90                  95      


Val Ser Trp Glu Ala Phe Glu Arg Ala Gly Ile Glu Pro Gly Ser Val 
            100                 105                 110         


Arg Gly Ser Asp Thr Gly Val Phe Ile Gly Ala Phe Pro Val Gly Tyr 
        115                 120                 125             


Ala Ala Gly Ala Ala Arg Glu Gly Tyr Gly Ala Thr Ala Ala Pro Asn 
    130                 135                 140                 


Val Leu Ser Gly Arg Leu Ser Tyr Phe Phe Gly Leu Glu Gly Pro Ala 
145                 150                 155                 160 


Ile Thr Met Asp Thr Ala Cys Ser Ser Ser Leu Val Ala Leu His Leu 
                165                 170                 175     


Ala Ala Gln Ala Val Arg Asn Gly Glu Cys Ser Met Ala Leu Ala Gly 
            180                 185                 190         


Gly Val Thr Val Met Ala Thr Pro Glu Val Phe Thr Glu Phe Ala Arg 
        195                 200                 205             


Gln Arg Gly Leu Ala Ser Asp Gly Arg Cys Lys Ala Phe Ala Asp Ser 
    210                 215                 220                 


Ala Asp Gly Ala Gly Phe Ser Glu Gly Ala Gly Leu Leu Leu Val Glu 
225                 230                 235                 240 


Arg Leu Ser Asp Ala Arg Arg Asn Gly His Gln Val Leu Ala Val Val 
                245                 250                 255     


Arg Gly Ser Ala Val Asn Gln Asp Gly Ala Ser Asn Gly Phe Thr Ala 
            260                 265                 270         


Pro Asn Gly Pro Ser Gln Gln Arg Val Ile Gln Gln Ala Leu Ala Asn 
        275                 280                 285             


Ala Gly Leu Thr Thr Ala Glu Val Asp Val Val Glu Ala His Gly Thr 
    290                 295                 300                 


Gly Thr Thr Leu Gly Asp Pro Ile Glu Ala Gln Ala Val Leu Ala Thr 
305                 310                 315                 320 


Tyr Gly Gln Asp Arg Glu Gln Pro Leu Leu Leu Gly Thr Leu Lys Ser 
                325                 330                 335     


Asn Ile Gly His Thr Gln Ala Ala Ala Gly Val Ser Gly Val Ile Lys 
            340                 345                 350         


Met Val Met Ala Leu Gln His Asp Thr Val Pro Arg Thr Leu His Val 
        355                 360                 365             


Asn Glu Pro Ser Arg His Val Asp Trp Thr Ala Gly Ala Val Glu Leu 
    370                 375                 380                 


Val Thr Glu Asn Gln Ser Trp Pro Val Thr Asp Arg Pro Arg Arg Ala 
385                 390                 395                 400 


Gly Val Ser Ala Phe Gly Val Ser Gly Thr Asn Ala His Val Ile Leu 
                405                 410                 415     


Glu Ser Ala Pro Ala Pro Ser Val Asn Asn Ala Gln Pro Val Glu Thr 
            420                 425                 430         


Pro Val Val Ala Ser Glu Leu Val Pro Leu Val Ile Ser Ala Lys Thr 
        435                 440                 445             


Leu Pro Ala Leu Thr Glu His Glu Asp Arg Leu Arg Ala Tyr Leu Ala 
    450                 455                 460                 


Ala Ser Pro Glu Ala Asp Met Pro Ala Val Ala Ser Thr Leu Ala Val 
465                 470                 475                 480 


Thr Arg Ser Val Phe Glu His Arg Ala Val Leu Leu Gly Asp Asp Thr 
                485                 490                 495     


Val Thr Gly Thr Gly Ala Ala Val Ser Asp Pro Arg Val Val Phe Val 
            500                 505                 510         


Phe Pro Gly Gln Gly Trp Gln Trp Leu Gly Met Gly Ser Gly Leu Arg 
        515                 520                 525             


Gly Ser Ser Val Val Phe Ala Glu Arg Met Ala Glu Cys Ala Ala Ala 
    530                 535                 540                 


Leu Arg Glu Phe Val Asp Trp Asp Leu Phe Ala Val Leu Asp Asp Pro 
545                 550                 555                 560 


Ala Val Val Asp Arg Val Asp Val Val Gln Pro Ala Ser Trp Ala Val 
                565                 570                 575     


Met Val Ser Leu Ala Ala Val Trp Glu Ala Ala Gly Val Arg Pro Asp 
            580                 585                 590         


Ala Val Val Gly His Ser Gln Gly Glu Ile Ala Ala Ala Cys Val Ala 
        595                 600                 605             


Gly Ala Val Ser Leu Arg Asp Ala Ala Arg Ile Val Thr Leu Arg Ser 
    610                 615                 620                 


Gln Val Ile Ala Gly Leu Ala Gly Arg Gly Gly Met Ala Ser Val Ala 
625                 630                 635                 640 


Leu Pro Ala His Glu Ile Glu Leu Val Glu Gly Ala Trp Ile Ala Ala 
                645                 650                 655     


Arg Asn Gly Pro Ala Ala Thr Val Ile Ala Gly Glu Pro Asp Ala Val 
            660                 665                 670         


Asp Arg Val Leu Ala Ile His Glu Ala Gln Gly Val Arg Val Arg Arg 
        675                 680                 685             


Ile Ala Val Asp Tyr Ala Ser His Thr Pro His Val Glu Leu Ile His 
    690                 695                 700                 


Asp Glu Leu Leu Gly Val Ile Ala Gly Val Asp Ser Gln Ala Pro Val 
705                 710                 715                 720 


Val Pro Trp Leu Ser Thr Val Asp Gly Thr Trp Val Glu Gly Pro Leu 
                725                 730                 735     


Asp Ala Glu Tyr Trp Tyr Arg Asn Leu Arg Glu Gln Val Gly Phe Asp 
            740                 745                 750         


Pro Ala Val Ser Gln Leu Arg Ala Glu Gly Asp Thr Val Phe Val Glu 
        755                 760                 765             


Val Ser Ala Ser Pro Val Leu Leu Gln Ala Met Asp Asp Asp Ala Ala 
    770                 775                 780                 


Thr Val Ala Thr Leu Arg Arg Asp Asp Gly Asp Ala Ala Arg Met Leu 
785                 790                 795                 800 


Thr Ala Leu Ala Gln Ala Phe Val Glu Gly Val Thr Val Asp Trp Pro 
                805                 810                 815     


Ala Ile Leu Gly Thr Ala Thr Pro Gly Val Leu Asp Leu Pro Thr Tyr 
            820                 825                 830         


Ala Phe Gln His Gln Arg Phe Trp Ala Glu Arg Trp Leu Ala Arg Leu 
        835                 840                 845             


Ala Pro Val Glu Arg Glu Lys Ala Leu Leu Lys Val Val Cys Asp Gly 
    850                 855                 860                 


Ala Ala Thr Val Leu Gly His Ala Asp Ala Ser Thr Ile Pro Ala Thr 
865                 870                 875                 880 


Ala Ala Phe Lys Asp Leu Gly Ile Asp Ser Leu Thr Ala Val Glu Leu 
                885                 890                 895     


Arg Asn Gly Leu Ala Lys Ala Thr Gly Leu Arg Leu Pro Ala Thr Leu 
            900                 905                 910         


Val Phe Asp Tyr Pro Thr Pro Thr Ala Leu Ala Ala Arg Leu 
        915                 920                 925     


<210>  41
<211>  893
<212>  PRT
<213>  Streptomyces violaceusniger

<400>  41

Glu Pro Leu Ala Ile Val Gly Met Ala Cys Arg Leu Pro Gly Gly Val 
1               5                   10                  15      


Ser Ser Pro Glu Asp Leu Trp Arg Leu Val Glu Ser Gly Thr Asp Ala 
            20                  25                  30          


Val Ser Gly Phe Pro Thr Asp Arg Gly Trp Asp Val Gly Asp Leu Phe 
        35                  40                  45              


Gly Pro Ala Ala Gly Asp Ser Tyr Arg Leu Arg Gly Gly Phe Leu Asp 
    50                  55                  60                  


Ala Ala Gly Gly Phe Asp Ala Ser Phe Phe Gly Ile Ser Pro Arg Glu 
65                  70                  75                  80  


Ala Leu Ala Met Asp Pro Gln Gln Arg Leu Val Leu Glu Val Ser Trp 
                85                  90                  95      


Glu Ala Phe Glu Arg Ala Gly Ile Glu Pro Gly Ser Val Arg Gly Thr 
            100                 105                 110         


Asp Thr Gly Val Phe Met Gly Ala Tyr Pro Gly Gly Tyr Gly Ile Gly 
        115                 120                 125             


Ala Asp Leu Gly Gly Phe Gly Ala Thr Ala Ser Ala Thr Ser Val Leu 
    130                 135                 140                 


Ser Gly Arg Val Ser Tyr Phe Phe Gly Leu Glu Gly Pro Ala Ile Thr 
145                 150                 155                 160 


Val Asp Thr Ala Cys Ser Ser Ser Leu Val Ala Leu His Gln Ala Gly 
                165                 170                 175     


Tyr Ala Leu Arg Gln Gly Glu Cys Ser Leu Ala Leu Val Gly Gly Val 
            180                 185                 190         


Thr Val Met Ala Thr Pro Gln Thr Phe Val Glu Phe Ala Arg Gln Gly 
        195                 200                 205             


Gly Leu Ala Gly Asp Gly Arg Ser Lys Ala Phe Ala Asp Ser Ala Asp 
    210                 215                 220                 


Gly Ala Gly Phe Ser Glu Gly Val Gly Val Leu Leu Val Glu Arg Leu 
225                 230                 235                 240 


Ser Asp Ala Gln Ala Lys Gly His Gln Val Leu Ala Met Leu Arg Ser 
                245                 250                 255     


Ser Ala Val Asn Gln Asp Gly Ala Ser Asn Gly Leu Thr Ala Pro Asn 
            260                 265                 270         


Gly Pro Ser Gln Gln Arg Val Ile Gln Ala Ala Leu Ser Asn Ala Gly 
        275                 280                 285             


Leu Ala Pro His Glu Val Asp Val Val Glu Ala His Gly Thr Gly Thr 
    290                 295                 300                 


Thr Leu Gly Asp Pro Ile Glu Ala Gln Ala Leu Leu Ala Thr Tyr Gly 
305                 310                 315                 320 


Gln Asp Arg Glu Arg Pro Leu Leu Leu Gly Ser Val Lys Ser Asn Leu 
                325                 330                 335     


Gly His Thr Gln Ala Ala Ala Gly Val Ser Gly Val Ile Lys Met Val 
            340                 345                 350         


Met Ala Leu Arg Asn Gly Leu Val Pro Arg Thr Leu His Val Asp Glu 
        355                 360                 365             


Pro Ser Arg His Val Asp Trp Ser Val Gly Ala Val Glu Leu Val Thr 
    370                 375                 380                 


Glu Asn Gln Ser Trp Pro Asp Ser Gly Arg Pro Arg Arg Ala Gly Val 
385                 390                 395                 400 


Ser Ser Phe Gly Ile Ser Gly Thr Asn Ala His Val Ile Leu Glu Ser 
                405                 410                 415     


Glu Pro Pro Ala Gln Val Val Glu Asn Thr Val Val Glu Pro Ala Pro 
            420                 425                 430         


Glu Trp Val Pro Leu Val Met Ser Ala Arg Thr Gln Ser Ala Leu Ala 
        435                 440                 445             


Asp Tyr Glu Asp Arg Leu Arg Ala Tyr Leu Ala Gly Ser Pro Gly Val 
    450                 455                 460                 


Asp Leu Arg Ala Val Gly Ser Thr Leu Ala Val Thr Arg Ser Val Phe 
465                 470                 475                 480 


Glu His Arg Ala Val Leu Leu Gly Asp Asp Thr Val Thr Gly Thr Ala 
                485                 490                 495     


Val Ser Asp Pro Arg Val Val Phe Val Phe Pro Gly Gln Gly Ser Gln 
            500                 505                 510         


Arg Ala Gly Met Gly Glu Glu Leu Ala Ala Ala Phe Pro Val Phe Ala 
        515                 520                 525             


Arg Ile His Gln Gln Val Trp Asp Leu Leu Asp Val Pro Asp Leu Glu 
    530                 535                 540                 


Val Asn Glu Thr Gly Tyr Ala Gln Pro Ala Leu Phe Ala Leu Gln Val 
545                 550                 555                 560 


Ala Leu Phe Gly Leu Leu Glu Ser Trp Gly Val Gly Pro Asp Ala Val 
                565                 570                 575     


Ile Gly His Ser Val Gly Glu Leu Ala Ala Gly Tyr Val Ser Gly Leu 
            580                 585                 590         


Trp Ser Leu Glu Asp Ala Cys Thr Leu Val Ser Ala Arg Ala Arg Leu 
        595                 600                 605             


Met Gln Ala Leu Pro Ala Gly Gly Val Met Val Ala Val Pro Val Ser 
    610                 615                 620                 


Glu Glu Glu Ala Glu Ala Val Leu Cys Glu Gly Val Glu Ile Ala Ala 
625                 630                 635                 640 


Val Asn Gly Pro Ser Ser Val Val Leu Ser Gly Asp Glu Ala Ala Val 
                645                 650                 655     


Leu Arg Ala Ala Ala Thr Leu Gly Lys Trp Thr Arg Leu Ala Thr Ser 
            660                 665                 670         


His Ala Phe His Ser Ala Arg Met Glu Pro Met Leu Glu Glu Phe Arg 
        675                 680                 685             


Ala Val Ala Glu Gly Leu Thr Tyr Arg Thr Pro Arg Leu Thr Met Ala 
    690                 695                 700                 


Ala Gly Asp Gln Ile Ala Thr Ala Glu Tyr Trp Val Arg Gln Val Arg 
705                 710                 715                 720 


Asp Val Val Arg Phe Gly Glu Gln Ala Ala Ser Cys Gly Asp Ala Val 
                725                 730                 735     


Phe Val Glu Leu Gly Ala Asp Arg Ser Leu Ala Arg Leu Val Asp Gly 
            740                 745                 750         


Val Ala Met Leu His Gly Asp His Glu Ala Gln Ala Ala Ile Ser Ala 
        755                 760                 765             


Leu Ala His Leu Tyr Val Ser Gly Val Ala Val Asp Trp Pro Ala Val 
    770                 775                 780                 


Leu Gly Asp Val Pro Gly Arg Val Leu Asp Leu Pro Thr Tyr Ala Phe 
785                 790                 795                 800 


Gln His Gln Arg Tyr Trp Leu Glu Gly Arg Trp Leu Ala Ala Leu Thr 
                805                 810                 815     


Pro Glu Glu Arg Ala Lys Ala Leu Val Lys Val Val Cys Asp Ser Ala 
            820                 825                 830         


Ala Thr Val Leu Gly His Ala Asp Ala Ser Thr Ile Pro Val Thr Ala 
        835                 840                 845             


Ala Phe Arg Asp Leu Gly Val Asp Ser Leu Thr Ala Val Glu Leu Arg 
    850                 855                 860                 


Asn Ser Leu Thr Lys Ala Thr Gly Leu Arg Leu Pro Ala Thr Leu Val 
865                 870                 875                 880 


Phe Asp Tyr Pro Thr Ala Gly Ala Leu Ala Ala Arg Leu 
                885                 890             


<210>  42
<211>  895
<212>  PRT
<213>  Streptomyces violaceusniger

<400>  42

Glu Pro Leu Ala Ile Val Gly Met Ala Cys Arg Leu Pro Gly Gly Val 
1               5                   10                  15      


Phe Ser Pro Glu Asp Leu Trp Arg Leu Val Glu Ser Gly Thr Asp Ala 
            20                  25                  30          


Ile Ser Gly Phe Pro Thr Asp Arg Gly Trp Asp Ala Glu Asn Leu Phe 
        35                  40                  45              


Asp Pro Asp Pro Asp Ala Ala Gly Lys Ser Tyr Cys Leu Glu Gly Gly 
    50                  55                  60                  


Phe Leu Glu Thr Ala Ala Asn Phe Asp Ala Ser Phe Phe Glu Ile Ser 
65                  70                  75                  80  


Pro Arg Glu Ala Leu Ala Met Asp Pro Gln Gln Arg Leu Val Leu Glu 
                85                  90                  95      


Ala Ser Trp Glu Ala Phe Glu Arg Ala Gly Ile Glu Pro Gly Ser Val 
            100                 105                 110         


Arg Gly Ser Asp Thr Gly Val Phe Met Gly Ala Phe Pro Gly Gly Tyr 
        115                 120                 125             


Gly Ile Gly Ala Asp Leu Glu Gly Tyr Gly Ala Thr Ser Gly Leu Asn 
    130                 135                 140                 


Val Leu Ser Gly Arg Leu Ser Tyr Phe Phe Gly Leu Glu Gly Pro Ala 
145                 150                 155                 160 


Val Thr Val Asp Thr Ala Cys Ser Ser Ser Leu Val Ala Leu His Gln 
                165                 170                 175     


Ala Gly Tyr Ala Leu Arg Gln Gly Glu Cys Ser Leu Ala Leu Val Gly 
            180                 185                 190         


Gly Val Thr Val Met Ala Thr Pro His Thr Phe Val Glu Phe Ser Arg 
        195                 200                 205             


Gln Arg Gly Leu Ala Ser Asp Gly Arg Cys Lys Ala Phe Ala Asp Ser 
    210                 215                 220                 


Ala Asp Gly Thr Gly Trp Ser Glu Gly Val Gly Val Leu Leu Val Glu 
225                 230                 235                 240 


Arg Leu Ser Asp Ala Gln Ala Lys Gly His Gln Val Leu Ala Val Val 
                245                 250                 255     


Arg Gly Ser Ala Val Asn Gln Asp Gly Ala Ser Asn Gly Leu Ser Ala 
            260                 265                 270         


Pro Asn Gly Pro Ser Gln Gln Arg Val Ile Arg Gln Ala Leu Ala Asn 
        275                 280                 285             


Ala Gly Leu Thr Ile Ala Glu Val Asp Val Val Glu Ala His Gly Thr 
    290                 295                 300                 


Gly Thr Thr Leu Gly Asp Pro Ile Glu Ala Gln Ala Leu Leu Ala Thr 
305                 310                 315                 320 


Tyr Gly Gln Asp Arg Glu Gln Pro Leu Leu Leu Gly Ser Val Lys Ser 
                325                 330                 335     


Asn Val Gly His Thr Gln Ala Ala Ala Gly Val Ser Gly Val Ile Lys 
            340                 345                 350         


Met Val Met Ala Leu Arg Asn Gly Leu Val Pro Arg Thr Leu His Val 
        355                 360                 365             


Asp Glu Pro Ser Arg His Val Asp Trp Ser Glu Gly Ala Val Glu Leu 
    370                 375                 380                 


Val Thr Glu Asn Gln Pro Trp Pro Glu Thr Gly Arg Pro Arg Arg Ala 
385                 390                 395                 400 


Gly Val Ser Ser Phe Gly Val Ser Gly Thr Asn Ala His Val Ile Leu 
                405                 410                 415     


Glu Ser Ala Pro Pro Ala Gln Val Val Asp Asn Thr Val Val Glu Ser 
            420                 425                 430         


Ala Pro Glu Trp Val Pro Leu Val Met Ser Ala Arg Thr Gln Ser Ala 
        435                 440                 445             


Leu Ala Asp Tyr Glu Asp Arg Leu Arg Ala Tyr Leu Ala Gly Ser Pro 
    450                 455                 460                 


Gly Val Asp Leu Arg Ala Val Ala Ser Thr Leu Ala Val Thr Arg Ser 
465                 470                 475                 480 


Val Phe Glu His Arg Ala Val Leu Met Gly Asp Asp Thr Val Thr Gly 
                485                 490                 495     


Thr Ala Val Ser Asp Pro Arg Val Val Phe Val Phe Pro Gly Gln Gly 
            500                 505                 510         


Ser Gln Arg Ala Gly Met Gly Glu Glu Leu Ala Ala Ala Phe Pro Val 
        515                 520                 525             


Phe Ala Arg Ile His Gln Gln Val Trp Asp Leu Leu Asp Val Pro Asp 
    530                 535                 540                 


Leu Glu Val Asn Glu Thr Gly Tyr Ala Gln Pro Ala Leu Phe Ala Leu 
545                 550                 555                 560 


Gln Val Ala Leu Phe Gly Leu Leu Glu Ser Trp Gly Val Arg Pro Asp 
                565                 570                 575     


Ala Val Val Gly His Ser Ala Gly Glu Leu Ala Ala Ala Tyr Val Ser 
            580                 585                 590         


Gly Val Trp Ser Leu Glu Asp Ala Cys Ala Leu Val Ser Ala Arg Ala 
        595                 600                 605             


Arg Leu Met Gln Ala Leu Pro Ala Gly Gly Val Met Val Ala Val Pro 
    610                 615                 620                 


Val Ser Glu Glu Glu Ala Glu Ala Val Leu Cys Glu Gly Val Glu Ile 
625                 630                 635                 640 


Ala Ala Val Asn Gly Pro Ser Ser Val Val Leu Ser Gly Asp Glu Ala 
                645                 650                 655     


Ala Val Leu Arg Ala Ala Ala Gly Leu Gly Lys Trp Thr Arg Leu Ala 
            660                 665                 670         


Thr Ser His Ala Phe His Ser Ala Arg Met Glu Pro Met Leu Glu Glu 
        675                 680                 685             


Phe Arg Ala Val Ala Glu Gly Leu Thr Tyr Arg Thr Pro Arg Leu Thr 
    690                 695                 700                 


Met Ala Ala Gly Asp Gln Val Ala Thr Ala Glu Tyr Trp Val Arg Gln 
705                 710                 715                 720 


Val Arg Asp Val Val Arg Phe Gly Glu Gln Val Ala Ser Phe Glu Asp 
                725                 730                 735     


Ala Val Phe Leu Glu Leu Gly Ala Asp Arg Ser Leu Ala Arg Leu Val 
            740                 745                 750         


Asp Gly Val Ala Met Leu His Gly Asp His Glu Ala Gln Ala Ala Ile 
        755                 760                 765             


Ser Ala Leu Ala His Leu Tyr Val Asn Gly Val Thr Ile Asp Trp Pro 
    770                 775                 780                 


Ala Val Leu Gly Gly Val Pro Gly Arg Val Leu Asp Leu Pro Thr Tyr 
785                 790                 795                 800 


Ala Phe Gln His Glu Arg Tyr Trp Ala Glu Ala Trp Leu Ala Ala Leu 
                805                 810                 815     


Ala Pro Ala Glu Arg Glu Lys Ala Leu Leu Lys Leu Val Ser Asp Gly 
            820                 825                 830         


Ala Ala Thr Val Leu Gly His Ala Asp Ala Ser Thr Ile Pro Val Thr 
        835                 840                 845             


Ala Ala Phe Lys Asp Leu Gly Ile Asp Ser Leu Thr Ala Val Glu Leu 
    850                 855                 860                 


Arg Asn Ser Leu Ala Lys Ala Thr Gly Leu Arg Leu Pro Ala Thr Leu 
865                 870                 875                 880 


Val Phe Asp Tyr Pro Thr Pro Thr Ala Leu Ala Ala Arg Leu Asp 
                885                 890                 895 


<210>  43
<211>  927
<212>  PRT
<213>  Streptomyces violaceusniger

<400>  43

Glu Pro Leu Ala Ile Val Gly Met Ala Cys Arg Leu Pro Gly Gly Val 
1               5                   10                  15      


Ser Ser Pro Glu Asp Leu Trp Arg Leu Val Glu Ser Gly Thr Asp Ala 
            20                  25                  30          


Ile Ser Gly Phe Pro Thr Asp Arg Gly Trp Asp Val Glu Asn Leu Tyr 
        35                  40                  45              


Asp Pro Asp Pro Asp Ala Pro Gly Lys Ser Tyr Ser Val Arg Gly Gly 
    50                  55                  60                  


Phe Leu Asp Ala Ala Ala Asn Phe Asp Ala Ser Phe Phe Gly Ile Ser 
65                  70                  75                  80  


Pro Arg Glu Ala Leu Ala Met Asp Pro Gln Gln Arg Leu Met Leu Glu 
                85                  90                  95      


Val Ser Trp Glu Ala Phe Glu Arg Ala Gly Ile Glu Pro Arg Ser Val 
            100                 105                 110         


Arg Gly Ser Asp Thr Gly Val Phe Ile Gly Ala Tyr Pro Gly Gly Tyr 
        115                 120                 125             


Gly Ile Gly Val Asp Phe Glu Gly Phe Gly Ala Thr Ala Gly Ala Ala 
    130                 135                 140                 


Ser Val Leu Ser Gly Arg Val Ser Tyr Phe Phe Gly Leu Glu Gly Pro 
145                 150                 155                 160 


Ala Phe Thr Val Asp Thr Ala Cys Ser Ser Ser Leu Val Ala Leu His 
                165                 170                 175     


Gln Ala Gly Tyr Ala Leu Arg Gln Gly Asp Cys Ser Leu Ala Leu Val 
            180                 185                 190         


Gly Gly Val Thr Val Met Ala Thr Pro Gln Thr Phe Val Glu Phe Ser 
        195                 200                 205             


Arg Gln Arg Gly Leu Ser Ala Asp Gly Arg Cys Lys Ala Phe Ala Asp 
    210                 215                 220                 


Ser Ala Asp Gly Thr Gly Trp Ala Glu Gly Val Gly Val Leu Leu Val 
225                 230                 235                 240 


Glu Arg Leu Ser Asp Ala Gln Ala Lys Gly His Gln Val Leu Gly Val 
                245                 250                 255     


Val Arg Gly Ser Ala Val Asn Gln Asp Gly Ala Ser Asn Gly Leu Ser 
            260                 265                 270         


Ala Pro Asn Gly Pro Ser Gln Gln Arg Val Ile Arg Ala Ala Leu Ser 
        275                 280                 285             


Asn Ala Gly Leu Ala Pro His Glu Val Asp Val Val Glu Ala His Gly 
    290                 295                 300                 


Thr Gly Thr Thr Leu Gly Asp Pro Ile Glu Ala Gln Ala Leu Leu Ala 
305                 310                 315                 320 


Thr Tyr Gly Gln Gly Arg Gly Glu Pro Leu Leu Leu Gly Ser Leu Lys 
                325                 330                 335     


Ser Asn Ile Gly His Thr Gln Ala Ala Ala Gly Val Ser Gly Val Ile 
            340                 345                 350         


Lys Met Val Met Ala Leu Gln Tyr Gly Leu Val Pro Arg Thr Leu His 
        355                 360                 365             


Val Asp Glu Pro Ser Arg His Val Asp Trp Thr Ala Gly Ala Val Glu 
    370                 375                 380                 


Leu Val Gly Glu Asn Gln Pro Trp Pro Glu Thr Gly Arg Pro His Arg 
385                 390                 395                 400 


Ala Gly Val Ser Ser Phe Gly Ile Ser Gly Thr Asn Ala His Val Ile 
                405                 410                 415     


Leu Glu Ser Ala Pro Ala Gln Pro Ala Glu Glu Ala Gln Pro Val Val 
            420                 425                 430         


Thr Pro Val Val Ala Ser Glu Leu Val Pro Leu Val Val Ser Ala Lys 
        435                 440                 445             


Thr Glu Ser Ala Leu Thr Glu Val Glu Gly Arg Leu Arg Ala Tyr Leu 
    450                 455                 460                 


Ala Ala Ser Pro Gly Val Asp Thr Arg Ala Val Ala Ser Thr Leu Ala 
465                 470                 475                 480 


Val Thr Arg Ser Val Phe Glu His Arg Ala Val Leu Leu Gly Asp Asp 
                485                 490                 495     


Thr Val Thr Gly Thr Gly Thr Ala Met Ser Asp Pro Arg Val Val Phe 
            500                 505                 510         


Val Phe Pro Gly Gln Gly Trp Gln Trp Leu Gly Met Gly Ser Ala Leu 
        515                 520                 525             


Arg Asp Ser Ser Val Val Phe Ala Glu Arg Met Ala Glu Cys Ala Ala 
    530                 535                 540                 


Ala Leu Ser Asp Phe Val Asp Trp Asp Leu Phe Thr Val Leu Asp Asp 
545                 550                 555                 560 


Pro Ala Val Val Asp Arg Val Asp Val Val Gln Pro Ala Ser Trp Ala 
                565                 570                 575     


Val Met Val Ser Leu Ala Ala Val Trp Gln Ala Ala Gly Val Arg Pro 
            580                 585                 590         


Asp Ala Val Ile Gly His Ser Gln Gly Glu Ile Ala Ala Ala Cys Ile 
        595                 600                 605             


Ala Gly Ala Val Ser Leu Arg Asp Ala Ala Arg Ile Val Thr Leu Arg 
    610                 615                 620                 


Ser Gln Ala Ile Ala Gly Leu Ala Gly Arg Gly Ala Met Ala Ser Ile 
625                 630                 635                 640 


Ala Leu Pro Ala Gln Glu Ile Gly Leu Ala Asp Gly Ala Trp Ile Ala 
                645                 650                 655     


Ala His Asn Gly Pro Ala Ser Thr Val Ile Ala Gly Ala Pro Glu Ala 
            660                 665                 670         


Val Asp Arg Val Leu Thr Ala His Glu Ala Gln Gly Ala Arg Val Arg 
        675                 680                 685             


Arg Ile Ala Val Asp Tyr Ala Ser His Thr Pro His Val Glu Leu Ile 
    690                 695                 700                 


Arg Asp Glu Leu Leu Asp Ile Thr Ala Gly Ile Gly Ser Gln Ala Pro 
705                 710                 715                 720 


Val Val Pro Trp Leu Ser Thr Val Asp Gly Thr Trp Val Glu Gly Pro 
                725                 730                 735     


Leu Asp Ala Glu Tyr Trp Tyr Arg Asn Leu Arg Glu Pro Val Gly Phe 
            740                 745                 750         


Ala Pro Ala Val Arg Gln Leu Gln Ala Gln Gly Glu Thr Val Phe Val 
        755                 760                 765             


Glu Val Ser Ala Ser Pro Val Leu Leu Gln Ala Met Asp Asp Asp Ala 
    770                 775                 780                 


Val Thr Val Ala Thr Leu Arg Arg Asp Asp Gly Asp Ala Thr Arg Met 
785                 790                 795                 800 


Leu Thr Ala Leu Ala Gln Ala Tyr Thr His Gly Val Thr Val Asp Trp 
                805                 810                 815     


Pro Ala Ile Leu Gly Thr Thr Thr Thr Arg Ala Leu Asp Leu Pro Thr 
            820                 825                 830         


Tyr Ala Phe Gln His Glu Arg Tyr Trp Ala Glu Ala Trp Leu Val Gly 
        835                 840                 845             


Leu Ala Pro Glu Glu Arg Ala Lys Ala Leu Leu Lys Leu Val Ser Asp 
    850                 855                 860                 


Ser Ala Ala Ala Val Leu Gly His Ala Asp Ala Arg Gly Ile Pro Ala 
865                 870                 875                 880 


Thr Gly Ala Phe Lys Asp Leu Gly Val Asp Ser Leu Thr Ala Val Glu 
                885                 890                 895     


Leu Arg Asn Thr Leu Thr Lys Ala Thr Gly Leu Arg Leu Pro Ala Thr 
            900                 905                 910         


Met Val Phe Asp Tyr Pro Thr Pro Ala Asp Leu Ala Ala Arg Leu 
        915                 920                 925         


<210>  44
<211>  916
<212>  PRT
<213>  Streptomyces hygroscopicus

<400>  44

Glu Pro Leu Ala Ile Val Gly Met Ala Cys Arg Leu Pro Gly Gly Val 
1               5                   10                  15      


Ser Ser Pro Glu Glu Leu Trp Gln Leu Val Glu Ser Gly Gly Asp Ala 
            20                  25                  30          


Ile Ser Pro Phe Pro Thr Asp Arg Gly Trp Asp Leu Glu Thr Pro Tyr 
        35                  40                  45              


Arg Gly Gly Phe Leu Thr Asp Pro Ala Gly Phe Asp Ala Gly Phe Phe 
    50                  55                  60                  


Gly Ile Ser Pro Arg Glu Ala Val Ala Met Asp Pro Gln Gln Arg Val 
65                  70                  75                  80  


Leu Leu Glu Ala Ser Trp Glu Ala Phe Glu Arg Ala Gly Ile Lys Pro 
                85                  90                  95      


Asp Ser Leu Arg Gly Ser Asp Thr Gly Val Phe Val Gly Gly Phe Ser 
            100                 105                 110         


Gln Gly Tyr Gly Thr Gly Ala Asp Leu Gly Gly Phe Gly Ala Thr Ser 
        115                 120                 125             


Thr Gln Thr Ser Val Leu Ser Gly Arg Leu Ser Tyr Phe Tyr Gly Phe 
    130                 135                 140                 


Glu Gly Pro Ala Val Thr Val Asp Thr Ala Cys Ser Ser Ser Leu Val 
145                 150                 155                 160 


Ala Leu His Gln Ala Ala Ser Ser Leu His Ile Gly Glu Cys Ser Leu 
                165                 170                 175     


Ala Val Val Gly Gly Val Thr Val Val Ala Thr Pro Gly Gly Phe Val 
            180                 185                 190         


Glu Phe Ala Arg Gln Gly Gly Leu Ala Leu Asp Gly Arg Cys Lys Ala 
        195                 200                 205             


Phe Ala Asp Ala Ala Asp Gly Ile Gly Leu Ala Glu Gly Val Gly Val 
    210                 215                 220                 


Leu Leu Val Glu Arg Leu Ser Asp Ala Gln Arg Asn Gly His Thr Val 
225                 230                 235                 240 


Leu Ala Val Val Arg Gly Ser Ala Val Asn Gln Asp Gly Ala Ser Asn 
                245                 250                 255     


Gly Leu Ser Ala Pro Asn Gly Pro Ser Gln Gln Arg Val Ile Arg Gln 
            260                 265                 270         


Ala Leu Ala Asn Ala Arg Leu Thr Pro Ala Asp Ile Asp Val Val Glu 
        275                 280                 285             


Ala His Gly Thr Gly Thr Arg Leu Gly Asp Pro Ile Glu Ala Gln Ala 
    290                 295                 300                 


Ile Leu Ala Thr Tyr Gly Gln Asp Arg Asp Gln Pro Leu Leu Leu Gly 
305                 310                 315                 320 


Ser Leu Lys Ser Asn Ile Gly His Thr Gln Ala Ala Ala Gly Val Ala 
                325                 330                 335     


Gly Val Ile Lys Thr Val Met Ala Met Arg His Gly Thr Ala Pro Arg 
            340                 345                 350         


Thr Leu His Ala Asp Glu Pro Ser Arg His Val Asp Trp Ser Ala Gly 
        355                 360                 365             


Ala Val Glu Leu Leu Ser Glu Asn Arg Leu Trp Pro Glu Thr Asp Arg 
    370                 375                 380                 


Pro Arg Arg Ala Ala Val Ser Ser Phe Gly Val Ser Gly Thr Asn Ala 
385                 390                 395                 400 


His Val Ile Leu Glu Ser Ala Pro Ala Glu Ser Ala Glu Gly Pro Ala 
                405                 410                 415     


Gly Met Gly Ser Glu Ser Met Gly Ser Glu Ser Gly Pro Val Val Val 
            420                 425                 430         


Val Leu Ser Ala Lys Ser Ala Ser Ala Leu Ala Gly Gln Glu Glu Arg 
        435                 440                 445             


Leu Arg Ala Tyr Leu Ala Ser Gly Ala Asp Val Arg Ala Val Ala Ala 
    450                 455                 460                 


Gly Leu Ala Arg Arg Ser Val Phe Glu His Arg Ser Val Ile Leu Gly 
465                 470                 475                 480 


Asp Ser Thr Val Ser Gly Val Ala Ala Gly Val Pro Arg Val Val Phe 
                485                 490                 495     


Leu Phe Pro Gly Gln Gly Thr Gln Trp Ala Gly Met Gly Ala Asp Leu 
            500                 505                 510         


Leu Glu Ser Ser Pro Val Phe Ala Ala Arg Met Arg Gln Cys Ala Ala 
        515                 520                 525             


Glu Leu Ser Lys Tyr Thr Asp Trp Asp Leu Phe Thr Ala Leu Ser Asp 
    530                 535                 540                 


Pro Ala Leu Leu Asp Arg Val Asp Val Val Gln Pro Val Ser Trp Ala 
545                 550                 555                 560 


Leu Met Val Ser Leu Ala Ala Leu Trp Gln His Cys Gly Val Gln Pro 
                565                 570                 575     


Asp Ala Val Ile Gly His Ser Gln Gly Glu Ile Ala Ala Ala Cys Val 
            580                 585                 590         


Ala Gly Ala Leu Thr Leu Gln Asp Gly Ala Arg Leu Ile Thr Gly Arg 
        595                 600                 605             


Ser Ala Leu Ile Ala His Leu Ser Gly Arg Gly Thr Met Ala Ser Ile 
    610                 615                 620                 


Ala Leu Pro Ala Asp Asp Leu Thr Leu Pro Asp Asp Val Cys Ile Ala 
625                 630                 635                 640 


Ala Val Asn Gly Pro Ala Thr Thr Ile Ile Ala Gly Pro Thr Pro Ala 
                645                 650                 655     


Ile Glu His Leu Leu Ala Thr Tyr Glu Ala Ser Asn Ile His Thr Arg 
            660                 665                 670         


Arg Ile Pro Val Asp Tyr Pro Ser His Thr Pro His Val Glu Asp Leu 
        675                 680                 685             


His Asp Pro Leu Leu Ala Ile Thr Thr His Leu Thr Pro His Thr Pro 
    690                 695                 700                 


Thr Thr Pro Trp Leu Ser Thr Val Asp Asn Thr Trp Ile His Thr Pro 
705                 710                 715                 720 


Pro His Pro Asp Tyr Trp Tyr Arg Asn Leu Arg His Pro Val Gln Leu 
                725                 730                 735     


Ala Pro Ala Ile Thr Thr Leu Thr His Pro His Pro Thr His Leu Ile 
            740                 745                 750         


Glu Ile Ser Thr His Pro Val Leu Leu Pro Ala Ile Asp Thr Thr Thr 
        755                 760                 765             


Thr Leu Thr Thr Thr Ala Thr Leu Arg Arg Asn His Gly Thr Pro His 
    770                 775                 780                 


Gln Leu Leu Thr Ser Leu Ala His Ala His Thr His Gly Ala Thr Ile 
785                 790                 795                 800 


Asn Trp Pro Ala Leu Leu Gly Asn Pro Pro Thr Ala Thr Thr Ala Asp 
                805                 810                 815     


Leu Pro Thr Tyr Pro Phe Gln His Lys Arg Tyr Trp Leu Gln Asp Thr 
            820                 825                 830         


Glu Arg Val Ala Gly Leu Pro Ala Ala Glu Arg Glu Gln Val Val Val 
        835                 840                 845             


Lys Ala Val Cys Glu Thr Ala Ala Val Val Leu Gly His Ala His Ala 
    850                 855                 860                 


Asp Asp Ile Leu Ala Thr Thr Leu Phe Lys Asp Leu Gly Val Asp Ser 
865                 870                 875                 880 


Leu Ile Ala Val Glu Leu Arg Asn Arg Leu Ala Ala Asp Ala Gly Leu 
                885                 890                 895     


Arg Leu Pro Ala Thr Leu Val Phe Asp Tyr Pro Thr Pro His Ala Leu 
            900                 905                 910         


Ala Thr Trp Leu 
        915     


<210>  45
<211>  875
<212>  PRT
<213>  Streptomyces hygroscopicus

<400>  45

Glu Pro Leu Ala Ile Val Gly Met Ala Cys Arg Phe Pro Gly Gly Val 
1               5                   10                  15      


Ser Ser Pro Glu Asp Leu Trp Arg Leu Val Glu Ser Gly Gly Asp Ala 
            20                  25                  30          


Ile Ser Asp Ile Pro Ala Asp Arg Gly Trp Asp Leu Glu Thr Pro Tyr 
        35                  40                  45              


Arg Gly Gly Phe Leu Ala Asp Ala Gly Gly Phe Asp Ala Gly Phe Phe 
    50                  55                  60                  


Gly Ile Ser Pro Arg Glu Ala Leu Ala Met Asp Pro Gln Gln Arg Val 
65                  70                  75                  80  


Leu Leu Glu Thr Ser Trp Glu Ala Leu Glu Arg Ala Glu Ile Glu Pro 
                85                  90                  95      


Gly Ser Leu Arg Gly Ser Asp Thr Gly Val Phe Ile Gly Gly Phe Ser 
            100                 105                 110         


Gln Ser Tyr Gly Ile Gly Ala Asp Leu Gly Gly Phe Gly Thr Thr Gly 
        115                 120                 125             


Ile Gln Thr Ser Val Leu Ser Gly Arg Leu Ser Tyr Phe Phe Gly Phe 
    130                 135                 140                 


Glu Gly Pro Ala Phe Thr Val Asp Thr Ala Cys Ser Ser Ser Leu Val 
145                 150                 155                 160 


Ala Leu His Gln Ala Ser Ser Ala Leu Arg Gln Gly Glu Cys Ser Leu 
                165                 170                 175     


Ala Leu Val Gly Gly Val Thr Val Leu Ala Asp Pro Ser Gly Phe Val 
            180                 185                 190         


Glu Phe Ala Arg Gln Gly Gly Leu Ala Ala Asp Gly Arg Cys Lys Ala 
        195                 200                 205             


Phe Ala Asp Thr Ala Asp Gly Thr Ser Leu Ala Glu Gly Val Gly Val 
    210                 215                 220                 


Leu Leu Val Glu Arg Leu Ser Asp Ala Gln Arg Asn Gly His Thr Val 
225                 230                 235                 240 


Leu Ala Val Val Arg Gly Ser Ala Val Asn Gln Asp Gly Ala Ser Asn 
                245                 250                 255     


Gly Leu Ser Ala Pro Asn Gly Pro Ser Gln Gln Arg Val Ile Arg Gln 
            260                 265                 270         


Ala Leu Ala Asn Ala Arg Leu Thr Pro Ala Asp Ile Asp Val Val Glu 
        275                 280                 285             


Ala His Gly Thr Gly Thr Arg Leu Gly Asp Pro Ile Glu Ala Gln Ala 
    290                 295                 300                 


Ile Leu Ala Thr Tyr Gly Gln Asp Arg Asp Gln Pro Val Leu Ile Gly 
305                 310                 315                 320 


Ser Leu Lys Ser Asn Ile Gly His Thr Gln Ala Ala Ala Gly Val Ala 
                325                 330                 335     


Gly Val Ile Lys Met Val Met Ala Met Arg Gln Gly Thr Val Pro Arg 
            340                 345                 350         


Thr Leu His Val Asp Glu Pro Ser His His Val Asp Trp Thr Ala Gly 
        355                 360                 365             


Ser Val Gln Pro Ile Thr Gln Asn Gln Glu Trp Pro Gln Ala Gly Arg 
    370                 375                 380                 


Val Arg Arg Ala Gly Val Ser Ser Phe Gly Ile Ser Gly Thr Asn Ala 
385                 390                 395                 400 


His Val Ile Ile Glu Gly Val Pro Val Ala Glu Pro Val Val Val Ala 
                405                 410                 415     


Asp Ser Gly Val Val Pro Leu Val Leu Ser Ala Arg Thr Pro Gly Ala 
            420                 425                 430         


Leu Leu Glu Gln Glu Glu Arg Leu Arg Ala Tyr Leu Ala Cys Gly Ala 
        435                 440                 445             


Asp Val Arg Ala Val Ala Ala Gly Leu Ala Arg Arg Ser Val Phe Glu 
    450                 455                 460                 


His Arg Ser Val Leu Val Gly Asp Thr Val Val Ser Gly Thr Ala Ala 
465                 470                 475                 480 


Asp Ala Arg Leu Val Leu Val Phe Ser Gly Gln Gly Ser Gln Arg Ala 
                485                 490                 495     


Gly Met Gly Glu Glu Leu Ala Ala Arg Phe Pro Val Phe Ala Glu Ile 
            500                 505                 510         


His Gln Arg Val Trp Asp Leu Leu Asp Val Gly Pro Gly Leu Asp Val 
        515                 520                 525             


Asp Asp Thr Gly Tyr Ala Gln Pro Ala Leu Phe Ala Leu Gln Val Ala 
    530                 535                 540                 


Leu Phe Gly Leu Leu Glu Ser Trp Gly Val Arg Pro Asp Val Leu Ile 
545                 550                 555                 560 


Gly His Ser Ile Gly Glu Leu Ala Ala Ala Cys Val Ser Gly Val Trp 
                565                 570                 575     


Ser Leu Gln Asp Ala Cys Ala Leu Val Ser Ala Arg Ala Arg Leu Met 
            580                 585                 590         


Gln Ala Leu Pro Ala Gly Gly Val Met Ala Ala Val Pro Val Ser Glu 
        595                 600                 605             


Ala Glu Ala Glu Ala Val Leu Arg Glu Gly Val Glu Ile Ala Ala Val 
    610                 615                 620                 


Asn Gly Pro Ala Ser Ile Val Leu Ser Gly Asp Glu Asp Ala Val Leu 
625                 630                 635                 640 


Gln Ala Ala Ala Ser Leu Gly Arg Phe Thr Arg Leu Ser Thr Ser His 
                645                 650                 655     


Ala Phe His Cys Ala Arg Met Asp Pro Met Leu Asp Glu Phe Arg Gln 
            660                 665                 670         


Val Ala Glu Ser Ile Ala Tyr Gln Pro Pro Arg Ile Ala Met Ala Ala 
        675                 680                 685             


Gly Asp Gln Val Ile Thr Pro Asp Tyr Trp Val Arg Gln Val Arg Glu 
    690                 695                 700                 


Pro Val Arg Phe Gly Asp Gln Val Ala Ala His Ala Asp Ala Val Phe 
705                 710                 715                 720 


Leu Glu Ile Gly Pro Asp Arg His Leu Ala Arg Leu Ile Asp Gly Ile 
                725                 730                 735     


Pro Thr Leu Ser Val Asp Glu Val Gln Ser Ala Met Thr Ala Leu Gly 
            740                 745                 750         


Glu Leu His Val Arg Gly Ile Asp Val Asp Trp Ala Thr Leu Leu Gly 
        755                 760                 765             


Thr Thr Pro Ala Thr Pro Thr Asp Ile Pro Thr Tyr Pro Phe Gln His 
    770                 775                 780                 


Lys His Tyr Trp Ile Asp Asn Arg Arg Ile Ser Gly Leu Glu Pro Ala 
785                 790                 795                 800 


Glu Arg Gly Gln Ala Leu Leu Glu Ile Val Arg Glu Ala Ala Ala Val 
                805                 810                 815     


Val Leu Gly His Thr Asp Ala Arg Glu Ile Ala Pro Thr Thr Ala Phe 
            820                 825                 830         


Arg Asp Leu Gly Ile Asp Ser Leu Thr Ala Ile Glu Leu Arg Asn Arg 
        835                 840                 845             


Val Ala Thr Glu Thr Gly Leu Arg Leu Pro Ala Thr Leu Val Phe Asp 
    850                 855                 860                 


His Pro Thr Pro Thr Thr Leu Ala Thr Trp Ile 
865                 870                 875 


<210>  46
<211>  922
<212>  PRT
<213>  Streptomyces hygroscopicus

<400>  46

Glu Pro Leu Ala Ile Val Gly Met Ala Cys Arg Leu Pro Gly Gly Ile 
1               5                   10                  15      


Ser Ser Pro Glu Asp Leu Trp Gln Leu Val Gln Ser Gly Gly Asp Ala 
            20                  25                  30          


Ile Thr Asp Leu Pro Thr Asp Arg Gly Trp Asp Leu Thr His Leu Tyr 
        35                  40                  45              


Asp Asn Asp Ala Pro Pro Val Tyr Arg Gly Gly Phe Leu Thr Asp Ala 
    50                  55                  60                  


Gly Asp Phe Asp Ala Ala Phe Phe Gly Ile Ser Pro Arg Glu Ala Leu 
65                  70                  75                  80  


Ala Met Asp Pro Gln Gln Arg Ile Leu Leu Glu Thr Ser Trp Glu Ala 
                85                  90                  95      


Phe Glu Arg Gly Gly Ile Asn Pro Glu Ala Ile Arg Gly Ser Asn Thr 
            100                 105                 110         


Gly Val Phe Ile Gly Gly Phe Ser Tyr Gly Tyr Gly Thr Gly Ala Asp 
        115                 120                 125             


Leu Gly Gly Phe Gly Ala Thr Ser Thr Gln Thr Ser Val Leu Ser Gly 
    130                 135                 140                 


Arg Leu Ser Tyr Phe Tyr Gly Phe Glu Gly Pro Ala Val Thr Val Asp 
145                 150                 155                 160 


Thr Ala Cys Ser Ser Ser Leu Val Ala Leu His Gln Ala Ser Ser Ala 
                165                 170                 175     


Leu Arg Gln Gly Glu Cys Ser Leu Ala Leu Ala Gly Gly Val Thr Val 
            180                 185                 190         


Met Ala Thr Pro Ala Gly Phe Glu Glu Phe Ala Arg Gln Gly Gly Leu 
        195                 200                 205             


Ala Ala Asp Gly Arg Cys Lys Ala Phe Ser Asp Thr Ala Asp Gly Thr 
    210                 215                 220                 


Gly Trp Ala Glu Gly Val Gly Val Leu Leu Val Glu Arg Leu Ser Asp 
225                 230                 235                 240 


Ala Gln Arg Asn Gly His Thr Val Leu Ala Val Val Arg Gly Ser Ala 
                245                 250                 255     


Val Asn Gln Asp Gly Ala Ser Asn Gly Leu Ser Ala Pro Asn Gly Pro 
            260                 265                 270         


Ser Gln Gln Arg Val Ile Arg Gln Ala Leu Ala Asn Ala Arg Leu Thr 
        275                 280                 285             


Pro Ala Asp Ile Asp Val Val Glu Ala His Gly Thr Gly Thr Arg Leu 
    290                 295                 300                 


Gly Asp Pro Ile Glu Ala Gln Ala Ile Leu Ala Thr Tyr Gly Gln Asp 
305                 310                 315                 320 


Arg Asp Gln Pro Leu Leu Leu Gly Ser Leu Lys Ser Asn Ile Gly His 
                325                 330                 335     


Thr Gln Ala Ala Ala Gly Val Ala Gly Ile Ile Lys Thr Val Met Ala 
            340                 345                 350         


Met Arg His Gly Thr Ala Pro Arg Thr Leu His Ala Asp Glu Pro Ser 
        355                 360                 365             


Arg His Val Asp Trp Ser Ala Gly Ala Val Glu Leu Leu Ser Glu Asn 
    370                 375                 380                 


Arg Leu Trp Pro Glu Thr Asp Arg Pro Arg Arg Ala Ala Val Ser Ser 
385                 390                 395                 400 


Phe Gly Val Ser Gly Thr Asn Ala His Val Ile Ile Glu Gln Pro Pro 
                405                 410                 415     


His Thr Pro Ala Pro Glu Ala Glu Arg Thr Thr Gly Leu Asp Val Val 
            420                 425                 430         


Pro Trp Leu Leu Ser Ala Arg Thr Pro Ala Gly Leu Arg Ala Gln Ala 
        435                 440                 445             


Glu Gln Val Ser Ser Leu Asn Glu Asp Phe Ala Asn Ile Gly Phe Ser 
    450                 455                 460                 


Leu Ala Thr Thr Arg Thr Pro Met Glu His Arg Ala Val Val Val Ala 
465                 470                 475                 480 


Asp Val Ser Gly Ile Ser Glu Ala Ala Val Phe Ala Gly Gly Gly Ser 
                485                 490                 495     


Pro Thr Asp Val Val Ser Gly Leu Ala Asn Val Arg Gly Lys Thr Val 
            500                 505                 510         


Phe Val Phe Pro Gly Gln Gly Ala Gln Trp Ala Gly Met Gly Ala Glu 
        515                 520                 525             


Leu Phe Ala Thr Ser Pro Val Phe Ala Glu Arg Met Thr Glu Cys Ala 
    530                 535                 540                 


Ala Ala Phe Ala Ala Leu Val Asp Trp Ser Leu Ile Asp Val Leu Gln 
545                 550                 555                 560 


Gln Arg Glu Gly Ala Pro Ser Pro Asp Arg Val Asp Val Val Gln Pro 
                565                 570                 575     


Leu Ser Phe Ala Val Met Val Ser Leu Ala Ala Leu Trp Lys Ser His 
            580                 585                 590         


Gly Val Val Pro Asp Ala Val Thr Gly His Ser Gln Gly Glu Val Ala 
        595                 600                 605             


Ala Ala Cys Val Ser Gly Ala Leu Ser Leu Ser Asp Ala Ala Thr Val 
    610                 615                 620                 


Val Ala Leu Arg Ser Arg Val Ile Ala Gln Leu Ala Gly His Gly Gly 
625                 630                 635                 640 


Met Val Ala Leu Pro Ala Thr Glu Phe Ala Ala Glu Tyr Trp Ala Gly 
                645                 650                 655     


Arg Leu Glu Leu Ala Ala Val Asn Gly Pro Ala Ser Val Val Val Ala 
            660                 665                 670         


Gly Glu Pro Glu Ala Leu Glu Glu Leu Leu Ala Glu Asn Pro Asn Ala 
        675                 680                 685             


Arg Arg Ile Pro Val Asp Tyr Ala Ser His Thr Ser Arg Val Glu Arg 
    690                 695                 700                 


Ile Arg Glu Glu Leu Thr Gly Leu Leu Ser Gly Leu Ala Pro Arg Gln 
705                 710                 715                 720 


Pro Ile Val Pro Phe Tyr Ser Thr Val Asp Asn Gln Trp Leu Asp Lys 
                725                 730                 735     


Pro Leu Asp Ala Glu Tyr Trp Tyr Arg Asn Leu Arg Gln Thr Val Arg 
            740                 745                 750         


Phe Ala Asp Ala Val His Gly Leu Ala Asp Ala Gly Phe Arg Ala Phe 
        755                 760                 765             


Val Glu Val Ser Pro His Pro Val Leu Thr Ser Ser Met Arg Asp Ile 
    770                 775                 780                 


Leu Asp Glu Arg Glu Thr Thr Ala Val Val Thr Gly Thr Leu Arg Arg 
785                 790                 795                 800 


Asp Ala His Gly Val Arg Glu Phe Val Arg Ser Leu Ala Arg Leu Trp 
                805                 810                 815     


Val Ser Gly Phe Ser Val Asp Trp Ser Gly Leu Phe Gly Asn Gly Pro 
            820                 825                 830         


Arg Arg Ile Pro Leu Pro Thr Tyr Pro Phe Gln Arg Asn Arg Tyr Trp 
        835                 840                 845             


Leu Gln Ala Glu Leu Asp Leu Val Arg Thr His Ala Ala Ala Val Leu 
    850                 855                 860                 


Gly His Ala Gly Pro Glu Ala Val Ala Ala Asp His Pro Phe Arg Asp 
865                 870                 875                 880 


Leu Gly Val Asp Ser Leu Ile Ala Val Glu Leu Arg Asn Arg Leu Ala 
                885                 890                 895     


Ala Glu Thr Gly Leu Arg Leu Pro Ala Thr Leu Val Phe Asp Tyr Pro 
            900                 905                 910         


Thr Pro Arg Ala Leu Ala Ala Trp Leu Asp 
        915                 920         


<210>  47
<211>  875
<212>  PRT
<213>  Streptomyces hygroscopicus

<400>  47

Glu Pro Leu Ala Ile Val Gly Met Ala Cys Arg Phe Pro Gly Gly Val 
1               5                   10                  15      


Ser Ser Pro Glu Asp Leu Trp Arg Leu Val Glu Thr Ser Gly Asp Ala 
            20                  25                  30          


Ile Ser Asp Ile Pro Ala Asp Arg Gly Trp Asp Leu Glu Thr Pro Tyr 
        35                  40                  45              


Arg Gly Gly Phe Leu Ile Gly Ala Ala Gly Phe Asp Ala Gly Phe Phe 
    50                  55                  60                  


Gly Ile Ser Pro Arg Glu Ala Leu Ala Met Asp Pro Gln Gln Arg Leu 
65                  70                  75                  80  


Leu Leu Glu Ile Ser Trp Glu Ala Leu Glu Arg Ala Gly Ile Asn Pro 
                85                  90                  95      


Glu Ser Val Arg Gly Ser Asp Thr Gly Val Phe Val Gly Gly Ser Ser 
            100                 105                 110         


Tyr Gly Tyr Gly Val Gly Ala Asp Leu Gly Gly Phe Gly Ala Thr Ser 
        115                 120                 125             


Thr His Ile Ser Val Leu Ser Gly Arg Val Ser Tyr Phe Phe Gly Phe 
    130                 135                 140                 


Glu Gly Pro Ala Phe Thr Val Asp Thr Ala Cys Ser Ser Ser Leu Val 
145                 150                 155                 160 


Ala Leu His Gln Ala Ser Ser Ala Leu Arg Gln Gly Glu Cys Ser Leu 
                165                 170                 175     


Ala Leu Val Gly Gly Val Thr Val Met Ala Thr Pro Ala Gly Phe Glu 
            180                 185                 190         


Glu Phe Ala Arg Gln Gly Gly Leu Ala Ala Asp Gly Arg Cys Lys Ala 
        195                 200                 205             


Phe Ser Asp Thr Ala Asp Gly Thr Ser Leu Ala Glu Gly Val Gly Val 
    210                 215                 220                 


Leu Leu Val Glu Arg Leu Ser Asp Ala Gln Arg Asn Gly His Thr Val 
225                 230                 235                 240 


Leu Ala Val Val Arg Gly Ser Ala Val Asn Gln Asp Gly Ala Ser Asn 
                245                 250                 255     


Gly Leu Ser Ala Pro Asn Gly Pro Ser Gln Gln Arg Val Ile Arg Gln 
            260                 265                 270         


Ala Leu Ala Asn Ala Arg Leu Thr Pro Ala Asp Ile Asp Val Val Glu 
        275                 280                 285             


Ala His Gly Thr Gly Thr Thr Leu Gly Asp Pro Ile Glu Ala Gln Ala 
    290                 295                 300                 


Ile Leu Ala Thr Tyr Gly Gln Asp Arg Asp Gln Pro Val Leu Ile Gly 
305                 310                 315                 320 


Ser Leu Lys Ser Asn Ile Gly His Thr Gln Ala Ala Ala Gly Val Ala 
                325                 330                 335     


Gly Val Ile Lys Met Val Met Ala Met Arg Gln Gly Thr Val Pro Arg 
            340                 345                 350         


Thr Leu His Val Asp Glu Pro Ser His His Val Asp Trp Thr Ala Gly 
        355                 360                 365             


Ser Val Gln Pro Ile Thr Gln Asn Gln Glu Trp Pro Gln Ala Gly Arg 
    370                 375                 380                 


Val Arg Arg Ala Gly Val Ser Ser Phe Gly Ile Ser Gly Thr Asn Ala 
385                 390                 395                 400 


His Val Ile Ile Glu Gly Val Pro Val Ala Glu Pro Val Val Val Ala 
                405                 410                 415     


Asp Ser Gly Val Val Pro Leu Val Leu Ser Ala Arg Thr Pro Gly Ala 
            420                 425                 430         


Leu Leu Glu Gln Glu Glu Arg Leu Arg Ala Tyr Leu Ala Cys Gly Ala 
        435                 440                 445             


Asp Val Arg Ala Val Ala Ala Gly Leu Ala Arg Arg Ser Val Phe Glu 
    450                 455                 460                 


His Arg Ser Val Leu Val Gly Asp Thr Val Val Ser Gly Thr Ala Ala 
465                 470                 475                 480 


Asp Ala Arg Leu Val Leu Val Phe Ser Gly Gln Gly Ser Gln Arg Ala 
                485                 490                 495     


Gly Met Gly Glu Glu Leu Ala Ala Arg Phe Pro Val Phe Ala Glu Ile 
            500                 505                 510         


His Gln Arg Val Trp Asp Leu Leu Asp Val Gly Pro Gly Leu Asp Val 
        515                 520                 525             


Asp Asp Thr Gly Tyr Ala Gln Pro Ala Leu Phe Ala Leu Gln Val Ala 
    530                 535                 540                 


Leu Phe Gly Leu Leu Glu Ser Trp Gly Val Arg Pro Asp Val Leu Ile 
545                 550                 555                 560 


Gly His Ser Ile Gly Glu Leu Ala Ala Ala Cys Val Ser Gly Val Trp 
                565                 570                 575     


Ser Leu Gln Asp Ala Cys Ala Leu Val Ser Ala Arg Ala Arg Leu Met 
            580                 585                 590         


Gln Ala Leu Pro Ala Gly Gly Val Met Ala Ala Val Pro Val Ser Glu 
        595                 600                 605             


Ala Glu Ala Glu Ala Val Leu Arg Glu Gly Val Glu Ile Ala Ala Val 
    610                 615                 620                 


Asn Gly Pro Ala Ser Ile Val Leu Ser Gly Asp Glu Asp Ala Val Leu 
625                 630                 635                 640 


Gln Ala Ala Ala Ser Leu Gly Arg Phe Thr Arg Leu Ser Thr Ser His 
                645                 650                 655     


Ala Phe His Cys Ala Arg Met Asp Pro Met Leu Asp Glu Phe Arg Gln 
            660                 665                 670         


Val Ala Glu Ser Ile Ala Tyr Gln Pro Pro Arg Ile Ala Met Ala Ala 
        675                 680                 685             


Gly Asp Gln Val Ile Thr Pro Asp Tyr Trp Val Arg Gln Val Arg Glu 
    690                 695                 700                 


Pro Val Arg Phe Gly Asp Gln Val Ala Ala His Ala Asp Ala Val Phe 
705                 710                 715                 720 


Leu Glu Ile Gly Pro Asp Arg His Leu Ala Arg Leu Ile Asp Gly Ile 
                725                 730                 735     


Pro Thr Leu Ser Val Asp Glu Val Gln Ser Ala Met Thr Ala Leu Gly 
            740                 745                 750         


Glu Leu His Val Arg Gly Ile Asp Val Asp Trp Ala Thr Leu Leu Gly 
        755                 760                 765             


Thr Thr Pro Ala Thr Pro Thr Asp Ile Pro Thr Tyr Pro Phe Gln His 
    770                 775                 780                 


Lys His Tyr Trp Ile Asp Asn Thr Arg Ile Ser Gly Leu Glu Pro Ala 
785                 790                 795                 800 


Glu Arg Gly Gln Ala Leu Leu Glu Ile Val Arg Glu Ala Ala Ala Val 
                805                 810                 815     


Val Leu Gly His Thr Asp Ala Arg Glu Ile Ala Pro Thr Thr Ala Phe 
            820                 825                 830         


Arg Asp Leu Gly Ile Asp Ser Leu Thr Ala Ile Glu Leu Arg Asn Arg 
        835                 840                 845             


Val Ala Thr Glu Thr Gly Leu Arg Leu Pro Ala Thr Leu Val Phe Asp 
    850                 855                 860                 


His Pro Thr Pro Thr Thr Leu Ala Thr Trp Ile 
865                 870                 875 


<210>  48
<211>  916
<212>  PRT
<213>  Streptomyces hygroscopicus

<400>  48

Glu Pro Leu Ala Ile Val Gly Met Ala Cys Arg Leu Pro Gly Gly Ile 
1               5                   10                  15      


Ser Ser Pro Glu Asp Leu Trp Gln Leu Val Gln Ser Gly Gly Asp Ala 
            20                  25                  30          


Ile Thr Asp Leu Pro Thr Asp Arg Gly Trp Asp Leu Glu Thr Pro Tyr 
        35                  40                  45              


Arg Gly Gly Phe Leu Thr Asp Pro Ala Gly Phe Asp Ala Gly Phe Phe 
    50                  55                  60                  


Gly Ile Ser Pro Arg Glu Ala Leu Ala Met Asp Pro Gln Gln Arg Val 
65                  70                  75                  80  


Leu Leu Glu Ala Ser Trp Glu Ala Phe Glu Arg Ala Gly Ile Lys Pro 
                85                  90                  95      


Asp Ser Leu Arg Gly Ser Asp Thr Gly Val Phe Val Gly Gly Phe Ser 
            100                 105                 110         


Gln Gly Tyr Gly Thr Gly Ala Asp Leu Gly Gly Phe Gly Ala Thr Ser 
        115                 120                 125             


Thr Gln Thr Ser Val Leu Ser Gly Arg Leu Ser Tyr Phe Tyr Gly Phe 
    130                 135                 140                 


Glu Gly Pro Ala Val Thr Val Asp Thr Ala Cys Ser Ser Ser Leu Val 
145                 150                 155                 160 


Ala Leu His Gln Ala Ser Ser Ala Leu Arg Gln Gly Glu Cys Ser Leu 
                165                 170                 175     


Ala Leu Ala Gly Gly Val Thr Val Met Ala Thr Pro Ala Gly Phe Glu 
            180                 185                 190         


Glu Phe Ala Arg Gln Gly Gly Leu Ala Ala Asp Gly Arg Cys Lys Ala 
        195                 200                 205             


Phe Ala Asp Thr Ala Asp Gly Thr Gly Trp Ala Glu Gly Val Gly Val 
    210                 215                 220                 


Leu Leu Val Glu Arg Leu Ser Asp Ala Gln Arg Asn Gly His Thr Val 
225                 230                 235                 240 


Leu Ala Val Val Arg Gly Ser Ala Val Asn Gln Asp Gly Ala Ser Asn 
                245                 250                 255     


Gly Leu Ser Ala Pro Asn Gly Pro Ser Gln Gln Arg Val Ile Arg Gln 
            260                 265                 270         


Ala Leu Ala Asn Ala Arg Leu Thr Pro Ala Asp Ile Asp Val Val Glu 
        275                 280                 285             


Ala His Gly Thr Gly Thr Arg Leu Gly Asp Pro Ile Glu Ala Gln Ala 
    290                 295                 300                 


Ile Leu Ala Thr Tyr Gly Gln Asp Arg Asp Gln Pro Leu Leu Leu Gly 
305                 310                 315                 320 


Ser Leu Lys Ser Asn Ile Gly His Thr Gln Ala Ala Ala Gly Val Ala 
                325                 330                 335     


Gly Ile Ile Lys Thr Val Met Ala Met Arg His Gly Thr Ala Pro Arg 
            340                 345                 350         


Thr Leu His Ala Asp Glu Pro Ser Arg His Val Asp Trp Ser Ala Gly 
        355                 360                 365             


Ala Val Glu Leu Leu Ser Glu Asn Arg Leu Trp Pro Glu Thr Asp Arg 
    370                 375                 380                 


Pro Arg Arg Ala Ala Val Ser Ser Phe Gly Val Ser Gly Thr Asn Ala 
385                 390                 395                 400 


His Val Ile Leu Glu Ser Ala Pro Ala Glu Ser Ala Glu Gly Pro Ala 
                405                 410                 415     


Gly Met Gly Ser Glu Ser Met Gly Ser Glu Ser Gly Pro Val Val Val 
            420                 425                 430         


Val Leu Ser Ala Lys Ser Ala Ser Ala Leu Ala Gly Gln Glu Glu Arg 
        435                 440                 445             


Leu Arg Ala Tyr Leu Ala Ser Gly Ala Asp Val Arg Ala Val Ala Ala 
    450                 455                 460                 


Gly Leu Ala Arg Arg Ser Val Phe Glu His Arg Ser Val Ile Leu Gly 
465                 470                 475                 480 


Asp Ser Thr Val Ser Gly Val Ala Ala Gly Val Pro Arg Val Val Phe 
                485                 490                 495     


Leu Phe Pro Gly Gln Gly Thr Gln Trp Ala Gly Met Gly Ala Asp Leu 
            500                 505                 510         


Leu Glu Ser Ser Pro Val Phe Ala Ala Arg Met Arg Gln Cys Ala Ala 
        515                 520                 525             


Glu Leu Ser Lys Tyr Thr Asp Trp Asp Leu Phe Thr Ala Leu Ser Asp 
    530                 535                 540                 


Pro Ala Leu Leu Asp Arg Val Asp Val Val Gln Pro Val Ser Trp Ala 
545                 550                 555                 560 


Leu Met Val Ser Leu Ala Ala Leu Trp Gln His Cys Gly Val Gln Pro 
                565                 570                 575     


Asp Ala Val Ile Gly His Ser Gln Gly Glu Ile Ala Ala Ala Cys Val 
            580                 585                 590         


Ala Gly Ala Leu Thr Leu Gln Asp Gly Ala Arg Leu Ile Thr Gly Arg 
        595                 600                 605             


Ser Ala Leu Ile Ala His Leu Ser Gly Arg Gly Thr Met Ala Ser Ile 
    610                 615                 620                 


Ala Leu Pro Ala Asp Asp Leu Thr Leu Pro Asp Asp Val Cys Ile Ala 
625                 630                 635                 640 


Ala Val Asn Gly Pro Ala Thr Thr Ile Ile Ala Gly Pro Thr Pro Ala 
                645                 650                 655     


Ile Glu His Leu Leu Ala Thr Tyr Glu Ala Ser Asn Ile His Thr Arg 
            660                 665                 670         


Arg Ile Pro Val Asp Tyr Pro Ser His Thr Pro His Val Glu Asp Leu 
        675                 680                 685             


His Asp Pro Leu Leu Ala Ile Thr Thr His Leu Thr Pro His Thr Pro 
    690                 695                 700                 


Thr Thr Pro Trp Leu Ser Thr Val Asp Asn Thr Trp Ile His Thr Pro 
705                 710                 715                 720 


Pro His Pro Asp Tyr Trp Tyr Arg Asn Leu Arg His Pro Val Gln Leu 
                725                 730                 735     


Ala Pro Ala Ile Thr Thr Leu Thr His Pro His Pro Thr His Leu Ile 
            740                 745                 750         


Glu Ile Ser Thr His Pro Val Leu Leu Pro Ala Ile Asp Thr Thr Thr 
        755                 760                 765             


Thr Leu Thr Thr Thr Ala Thr Leu Arg Arg Asn His Gly Thr Pro His 
    770                 775                 780                 


Gln Leu Leu Thr Ser Leu Ala His Ala His Thr His Gly Ala Thr Ile 
785                 790                 795                 800 


Asn Trp Pro Ala Leu Leu Gly Asn Pro Pro Thr Ala Thr Thr Ala Asp 
                805                 810                 815     


Leu Pro Thr Tyr Pro Phe Gln His Lys Arg Tyr Trp Leu Gln Asp Thr 
            820                 825                 830         


Glu Arg Leu Thr Thr Gln Ser Ser Val Glu Gln His Arg Leu Met Leu 
        835                 840                 845             


Asp Leu Val Thr Ser His Ala Ala Ala Val Leu Gly His Ser Ser Ala 
    850                 855                 860                 


Ala Ala Ile Thr Thr Asp Thr Pro Phe Arg Asp Leu Gly Phe Asp Ser 
865                 870                 875                 880 


Leu Thr Ala Val Glu Leu Arg Asn Arg Val Ala Ala Asp Thr Gly Leu 
                885                 890                 895     


Arg Leu Pro Ala Thr Leu Val Phe Asn His Pro Asn Ala Asp Ala Leu 
            900                 905                 910         


Thr Gln Tyr Leu 
        915     


<210>  49
<211>  950
<212>  PRT
<213>  Streptomyces hygroscopicus

<400>  49

Asp Pro Ile Ala Ile Val Ala Met Ala Cys Arg Leu Pro Gly Gly Val 
1               5                   10                  15      


Ser Ser Pro Glu Asp Leu Trp Arg Leu Val Glu Thr Gly Thr Asp Ala 
            20                  25                  30          


Ile Gly Pro Phe Pro Thr Asp Arg Gly Trp Asp Thr Glu Leu Tyr Pro 
        35                  40                  45              


Val Pro Asp Ala Pro Gly Lys Thr Tyr Cys Val Glu Gly Gly Phe Leu 
    50                  55                  60                  


Thr Gly Ala Ala Glu Phe Asp Ala Ala Phe Phe Asp Ile Ser Pro Arg 
65                  70                  75                  80  


Glu Ala Leu Ala Met Asp Pro Gln Gln Arg Leu Leu Leu Glu Thr Ser 
                85                  90                  95      


Trp Glu Ala Val Glu Arg Ala Arg Ile Asn Pro Lys Ser Leu Cys Gly 
            100                 105                 110         


Lys Asp Val Gly Val Tyr Val Gly Ala Ala Ala Gln Gly Tyr Gly Leu 
        115                 120                 125             


Gly Ala Gly Asp Gln Thr Glu Gly Thr Ala Ile Thr Gly Gly Ser Thr 
    130                 135                 140                 


Ser Leu Ser Ser Gly Arg Val Ser Tyr Ala Leu Gly Leu Glu Gly Pro 
145                 150                 155                 160 


Ala Val Thr Val Asp Thr Ala Cys Ser Ser Ser Leu Val Ala Met His 
                165                 170                 175     


Leu Ala Gly Gln Ala Leu Arg Gln Gly Glu Cys Ser Leu Ala Leu Val 
            180                 185                 190         


Gly Gly Val Ser Val Met Ala Ser Pro Ala Leu Phe Val Glu Phe Ser 
        195                 200                 205             


Arg Gln Arg Gly Leu Ala Ala Asp Gly Arg Cys Lys Ser Phe Ser Asp 
    210                 215                 220                 


Ala Ala Asp Gly Thr Asn Trp Ala Glu Gly Val Gly Val Leu Ile Leu 
225                 230                 235                 240 


Glu Arg Leu Ser Asp Ala Gln Arg Asn Gly His Pro Val Leu Ala Val 
                245                 250                 255     


Ile Arg Gly Ser Ala Ile Asn Ser Asp Gly Ala Ser Asn Gly Leu Thr 
            260                 265                 270         


Ala Pro Asn Gly Leu Ser Gln Gln Arg Val Ile Arg Gln Ala Leu Thr 
        275                 280                 285             


Ala Ala Gly Leu Arg Pro Glu Asp Val Asp Ala Val Glu Ala His Gly 
    290                 295                 300                 


Thr Gly Thr Arg Leu Gly Asp Pro Val Glu Ala Glu Ala Ile Leu Ala 
305                 310                 315                 320 


Thr Tyr Gly Gln Asn Arg Glu Gln Pro Leu Leu Leu Gly Ser Leu Lys 
                325                 330                 335     


Ser Asn Ile Gly His Ala Ala Ala Ala Ser Gly Val Ala Gly Val Ile 
            340                 345                 350         


Lys Met Val Gln Ala Met Arg Asn Gly Val Leu Pro Arg Thr Leu His 
        355                 360                 365             


Ile Asp Glu Pro Ser Ser Gln Val Asp Trp Thr Ser Gly Asn Val Ala 
    370                 375                 380                 


Leu Leu Thr Glu Ser Arg Pro Trp Pro Asp Glu Asp Lys Pro Arg Arg 
385                 390                 395                 400 


Ala Gly Val Ser Ser Phe Gly Ile Ser Gly Thr Asn Ala His Ile Val 
                405                 410                 415     


Leu Glu Gln Tyr Arg Ala Ala Glu Pro Glu Asp Arg Pro Gly Asp Gly 
            420                 425                 430         


Pro Gly Glu Arg Arg Pro Val Ala Trp Val Leu Ser Gly Lys Ser Pro 
        435                 440                 445             


Ala Ala Val Arg Ala Gln Ala Gly Arg Leu Arg Ala His Leu Val Gly 
    450                 455                 460                 


Thr Gln Gly Trp Arg Pro Val Asp Val Gly Tyr Ala Leu Ala Thr Thr 
465                 470                 475                 480 


Arg Ala Asp Phe Ala His Arg Ala Val Ala Val Gly Ser Gly Pro Glu 
                485                 490                 495     


Phe Leu His Ala Leu Glu Lys Leu Ala Glu Gly Ala Ser Trp Pro Arg 
            500                 505                 510         


Leu Thr Thr Asn Arg Ala Ser Ala Arg Arg Val Ala Phe Leu Phe Asp 
        515                 520                 525             


Gly Gln Gly Thr Gln Arg Leu Gly Met Gly Arg Glu Leu His Gln Arg 
    530                 535                 540                 


Phe Pro Ala Phe Ala Glu Ala Trp Asp Thr Val Asp Ala Glu Phe Ala 
545                 550                 555                 560 


Pro Tyr Leu Asp Arg Ser Leu Thr Glu Val Phe Phe Ser Asp Gly Gly 
                565                 570                 575     


Ser Gly Leu Met Asp Asp Thr Leu Tyr Ala Gln Ala Gly Leu Phe Ala 
            580                 585                 590         


Val Glu Thr Ala Leu Phe Arg Leu Leu Ala Gly Trp Gly Val Arg Pro 
        595                 600                 605             


Asp Phe Val Ala Gly His Ser Ala Gly Glu Ile Thr Ala Ala His Val 
    610                 615                 620                 


Ala Gly Val Leu Ser Val Thr Asp Ala Val Arg Leu Ile Val Ala Arg 
625                 630                 635                 640 


Gly Gln Ala Leu Arg Leu Ala Pro Pro Gly Ala Met Ala Ser Val Arg 
                645                 650                 655     


Ser Ser Ala Gln Glu Val Arg Asp Phe Ile Ala Gln Ser Gly Leu Pro 
            660                 665                 670         


Val Asp Leu Ala Ala Ile Asn Ser Pro Gly Ser Val Val Val Ala Gly 
        675                 680                 685             


Ser Pro Glu Thr Ile Ala Glu Phe Glu Gly Ala Trp Thr Ala Ser Gly 
    690                 695                 700                 


Arg Gln Ala Lys Arg Leu Ala Val Arg His Ala Phe His Ser Arg His 
705                 710                 715                 720 


Val Asp Gly Val Leu Asp Glu Phe Arg Ala Ala Leu Gly Gly Cys Arg 
                725                 730                 735     


Phe Gly Val Ala Glu Leu Pro Leu Val Ser Thr Ala Thr Gly Glu Leu 
            740                 745                 750         


Ala Ser Pro Asp Glu Leu Gly Thr Pro Glu His Trp Leu Arg His Ala 
        755                 760                 765             


Arg Gln Thr Val Arg Phe Gln Asp Ala Ile Arg Ala Leu Thr Glu Gln 
    770                 775                 780                 


Gly Val Asp Thr Phe Val Glu Ile Gly Pro Ser Gly Thr Leu Ala Ser 
785                 790                 795                 800 


Ala Gly Met Glu Cys Gly Gly Gly Thr Ala Ala Phe His Ala Val Met 
                805                 810                 815     


Arg Ala Arg Gln Pro Glu Glu Val Ser Leu Met Thr Ala Val Ala Glu 
            820                 825                 830         


Leu Tyr Ala Gly Gly Thr Pro Val Glu Trp Ser Arg Val Leu Asp Gly 
        835                 840                 845             


Arg Ser Val Val Asp Leu Pro Val Tyr Pro Phe Gln Arg Gln Pro Tyr 
    850                 855                 860                 


Trp Leu Ala Pro Ala Asp Glu Leu Ser Gln Pro Glu Gln Gln Lys Ala 
865                 870                 875                 880 


Leu Leu Glu Leu Val Lys Ala Glu Ala Ala Val Leu Leu Gly Ile Thr 
                885                 890                 895     


Asp Ala Thr Ala Ile Glu Asp Asp Ala Arg Phe Leu Glu Leu Gly Phe 
            900                 905                 910         


Asp Ser Leu Ser Ala Thr Arg Leu Arg Asn Gln Leu Ala Lys Ala Thr 
        915                 920                 925             


Gly Leu Ala Leu Glu Gln Thr Leu Leu Phe Asp Phe Pro Thr Pro Ala 
    930                 935                 940                 


Ala Leu Ala Ala His Leu 
945                 950 


<210>  50
<211>  879
<212>  PRT
<213>  Streptomyces hygroscopicus

<400>  50

Glu Pro Leu Ala Ile Val Gly Met Ala Cys Arg Leu Pro Gly Gly Val 
1               5                   10                  15      


Ser Ser Pro Glu Asp Leu Trp Arg Leu Val Glu Ser Gly Gly Asp Val 
            20                  25                  30          


Ile Ser Asp Phe Pro Thr Asp Arg Gly Trp Asp Thr Thr Gly Glu Asp 
        35                  40                  45              


Ser Ser Phe Ile Arg Gly Gly Phe Leu Thr Asp Ala Gly Gly Phe Asp 
    50                  55                  60                  


Ala Gly Phe Phe Gly Ile Ser Pro Arg Glu Ala Val Ala Met Asp Pro 
65                  70                  75                  80  


Gln Gln Arg Leu Val Leu Glu Thr Ser Trp Glu Val Leu Glu Arg Ala 
                85                  90                  95      


Gly Ile Glu Pro Gly Ser Leu Arg Gly Ser Asp Thr Gly Val Phe Ile 
            100                 105                 110         


Gly Gly Phe Ser Gln Gly Tyr Gly Ala Gly Ala Asp Leu Gly Gly Phe 
        115                 120                 125             


Gly Ala Thr Gly Thr Gln Thr Ser Val Leu Ser Gly Arg Val Ser Tyr 
    130                 135                 140                 


Tyr Leu Gly Leu Glu Gly Pro Ala Val Thr Val Asp Thr Ala Cys Ser 
145                 150                 155                 160 


Ser Ser Leu Val Ala Leu His Gln Ala Ala Ser Ala Leu Arg Gln Gly 
                165                 170                 175     


Glu Cys Ser Leu Ala Leu Val Gly Gly Val Thr Val Met Ala Thr Thr 
            180                 185                 190         


His Ser Phe Val Glu Phe Ala Arg Gln Gly Gly Leu Ser Ser Asp Gly 
        195                 200                 205             


Arg Cys Arg Ser Phe Ala Asp Ser Ala Asp Gly Thr Gly Trp Ala Glu 
    210                 215                 220                 


Gly Val Gly Val Leu Leu Val Glu Arg Leu Ser Asp Ala Arg Arg Ser 
225                 230                 235                 240 


Gly His Pro Val Leu Ala Leu Val Arg Gly Ser Ala Val Asn Gln Asp 
                245                 250                 255     


Gly Ala Ser Asn Gly Leu Ser Ala Pro Asn Gly Leu Ser Gln Gln Arg 
            260                 265                 270         


Val Ile Arg Gln Ala Leu Ala Thr Ala Gly Leu Asp Ala Ala Asp Val 
        275                 280                 285             


Asp Val Val Glu Ala His Gly Thr Gly Thr Val Leu Gly Asp Pro Ile 
    290                 295                 300                 


Glu Ala Gln Ala Ile Leu Ala Thr Tyr Gly Gln Gly Arg Glu Glu Pro 
305                 310                 315                 320 


Leu Leu Leu Gly Ser Leu Lys Ser Asn Val Gly His Thr Gln Ala Ala 
                325                 330                 335     


Ala Gly Val Ala Gly Val Ile Lys Met Val Met Ala Met Arg Gln Gly 
            340                 345                 350         


Thr Val Pro Arg Thr Leu His Val Asp Glu Pro Ser His His Val Asp 
        355                 360                 365             


Trp Thr Ala Gly Arg Val Glu Leu Leu Thr Glu Asn Arg Pro Trp Pro 
    370                 375                 380                 


Gln Ala Gly Arg Val Arg Arg Ala Gly Val Ser Ser Phe Gly Ile Ser 
385                 390                 395                 400 


Gly Thr Asn Ala His Val Ile Ile Glu Gly Val Pro Val Ala Glu Pro 
                405                 410                 415     


Val Val Val Ala Asp Ser Gly Val Val Pro Leu Val Leu Ser Ala Arg 
            420                 425                 430         


Thr Pro Gly Ala Leu Leu Glu Gln Glu Glu Arg Leu Arg Ala Tyr Leu 
        435                 440                 445             


Ala Cys Gly Ala Asp Val Arg Ala Val Ala Ala Gly Leu Ala Arg Arg 
    450                 455                 460                 


Ser Val Phe Glu His Arg Ser Val Leu Val Gly Asp Thr Val Val Ser 
465                 470                 475                 480 


Gly Thr Ala Ala Asp Ala Arg Leu Val Leu Val Phe Ser Gly Gln Gly 
                485                 490                 495     


Ser Gln Arg Ala Gly Met Gly Glu Glu Leu Ala Ala Arg Phe Pro Val 
            500                 505                 510         


Phe Ala Glu Ile His Gln Arg Val Trp Asp Leu Leu Asp Val Gly Pro 
        515                 520                 525             


Gly Leu Asp Val Asp Asp Thr Gly Tyr Ala Gln Pro Ala Leu Phe Ala 
    530                 535                 540                 


Leu Gln Val Ala Leu Phe Gly Leu Leu Glu Ser Trp Gly Val Arg Pro 
545                 550                 555                 560 


Asp Val Leu Ile Gly His Ser Ile Gly Glu Leu Ala Ala Ala Cys Val 
                565                 570                 575     


Ser Gly Val Trp Ser Leu Gln Asp Ala Cys Ala Leu Val Ser Ala Arg 
            580                 585                 590         


Ala Arg Leu Met Gln Ala Leu Pro Ala Gly Gly Val Met Ala Ala Val 
        595                 600                 605             


Pro Val Ser Glu Ala Glu Ala Glu Ala Val Leu Arg Glu Gly Val Glu 
    610                 615                 620                 


Ile Ala Ala Val Asn Gly Pro Ala Ser Ile Val Leu Ser Gly Asp Glu 
625                 630                 635                 640 


Asp Ala Val Leu Gln Ala Ala Ala Ser Leu Gly Arg Phe Thr Arg Leu 
                645                 650                 655     


Ser Thr Ser His Ala Phe His Cys Ala Arg Met Asp Pro Met Leu Asp 
            660                 665                 670         


Glu Phe Arg Gln Val Ala Glu Ser Ile Ala Tyr Gln Pro Pro Arg Ile 
        675                 680                 685             


Ala Met Ala Ala Gly Asp Gln Val Ile Thr Pro Asp Tyr Trp Val Arg 
    690                 695                 700                 


Gln Val Arg Glu Pro Val Arg Phe Gly Asp Gln Val Ala Ala His Ala 
705                 710                 715                 720 


Asp Ala Val Phe Leu Glu Ile Gly Pro Asp Arg His Leu Ala Arg Leu 
                725                 730                 735     


Ile Asp Gly Ile Pro Thr Leu Ser Val Asp Glu Val Gln Ser Ala Met 
            740                 745                 750         


Thr Ala Leu Gly Glu Leu His Val Arg Gly Ile Asp Val Asp Trp Ala 
        755                 760                 765             


Thr Leu Leu Gly Thr Thr Pro Ala Thr Pro Thr Asp Ile Pro Thr Tyr 
    770                 775                 780                 


Pro Phe Gln His Lys His Tyr Trp Ile Asp Asn Thr Arg Ile Ser Gly 
785                 790                 795                 800 


Leu Glu Pro Ala Glu Arg Gly Gln Ala Leu Leu Glu Ile Val Arg Glu 
                805                 810                 815     


Ala Ala Ala Val Val Leu Gly His Thr Asp Ala Arg Glu Ile Ala Pro 
            820                 825                 830         


Thr Thr Ala Phe Arg Asp Leu Gly Ile Asp Ser Leu Thr Ala Ile Glu 
        835                 840                 845             


Leu Arg Asn Arg Val Ala Thr Glu Thr Gly Leu Arg Leu Pro Ala Thr 
    850                 855                 860                 


Leu Val Phe Asp His Pro Thr Pro Thr Thr Leu Ala Thr Trp Ile 
865                 870                 875                 


<210>  51
<211>  913
<212>  PRT
<213>  Streptomyces hygroscopicus

<400>  51

Glu Pro Leu Ala Ile Val Gly Met Ala Cys Arg Leu Pro Gly Gly Ile 
1               5                   10                  15      


Ser Ser Pro Glu Asp Leu Trp Gln Leu Val Gln Ser Gly Gly Asp Ala 
            20                  25                  30          


Ile Thr Asp Leu Pro Thr Asp Arg Gly Trp Asp Leu Glu Thr Pro Tyr 
        35                  40                  45              


Arg Gly Gly Phe Leu Thr Asp Pro Ala Gly Phe Asp Ala Gly Phe Phe 
    50                  55                  60                  


Gly Ile Ser Pro Arg Glu Ala Leu Ala Met Asp Pro Gln Gln Arg Val 
65                  70                  75                  80  


Leu Leu Glu Ala Ser Trp Glu Ala Phe Glu Arg Ala Gly Ile Lys Pro 
                85                  90                  95      


Asp Ser Leu Arg Gly Ser Asp Thr Gly Val Phe Val Gly Gly Phe Ser 
            100                 105                 110         


Gln Gly Tyr Gly Thr Gly Ala Asp Leu Gly Gly Phe Gly Ala Thr Ser 
        115                 120                 125             


Thr Gln Thr Ser Val Leu Ser Gly Arg Leu Ser Tyr Phe Tyr Gly Phe 
    130                 135                 140                 


Glu Gly Pro Ala Val Thr Val Asp Thr Ala Cys Ser Ser Ser Leu Val 
145                 150                 155                 160 


Ala Leu His Gln Ala Ser Ser Ala Leu Arg Gln Gly Glu Cys Ser Leu 
                165                 170                 175     


Ala Leu Ala Gly Gly Val Thr Val Met Ala Thr Pro Ala Gly Phe Glu 
            180                 185                 190         


Glu Phe Ala Arg Gln Gly Gly Leu Ala Ala Asp Gly Arg Cys Lys Ala 
        195                 200                 205             


Phe Ala Asp Thr Ala Asp Gly Thr Gly Trp Ala Glu Gly Val Gly Val 
    210                 215                 220                 


Leu Leu Val Glu Arg Leu Ser Asp Ala Gln Arg Asn Gly His Thr Val 
225                 230                 235                 240 


Leu Ala Val Val Arg Gly Ser Ala Val Asn Gln Asp Gly Ala Ser Asn 
                245                 250                 255     


Gly Leu Ser Ala Pro Asn Gly Pro Ser Gln Gln Arg Val Ile Arg Gln 
            260                 265                 270         


Ala Leu Ala Asn Ala Arg Leu Thr Pro Ala Asp Ile Asp Val Val Glu 
        275                 280                 285             


Ala His Gly Thr Gly Thr Arg Leu Gly Asp Pro Ile Glu Ala Gln Ala 
    290                 295                 300                 


Ile Leu Ala Thr Tyr Gly Gln Asp Arg Asp Gln Pro Leu Leu Leu Gly 
305                 310                 315                 320 


Ser Leu Lys Ser Asn Ile Gly His Thr Gln Ala Ala Ala Gly Val Ala 
                325                 330                 335     


Gly Ile Ile Lys Thr Val Met Ala Met Arg His Gly Thr Ala Pro Arg 
            340                 345                 350         


Thr Leu His Ala Asp Glu Pro Ser Arg His Val Asp Trp Ser Ala Gly 
        355                 360                 365             


Ala Val Glu Leu Leu Ser Glu Asn Arg Leu Trp Pro Glu Thr Asp Arg 
    370                 375                 380                 


Pro Arg Arg Ala Ala Val Ser Ser Phe Gly Val Ser Gly Thr Asn Ala 
385                 390                 395                 400 


His Val Ile Leu Glu Ser Ala Pro Ala Glu Ser Ala Glu Gly Pro Ala 
                405                 410                 415     


Gly Met Gly Ser Glu Ser Met Gly Ser Glu Ser Gly Pro Val Val Val 
            420                 425                 430         


Val Leu Ser Ala Lys Ser Ala Ser Ala Leu Ala Gly Gln Glu Glu Arg 
        435                 440                 445             


Leu Arg Ala Tyr Leu Ala Ser Gly Ala Asp Val Arg Ala Val Ala Ala 
    450                 455                 460                 


Gly Leu Ala Arg Arg Ser Val Phe Glu His Arg Ser Val Ile Leu Gly 
465                 470                 475                 480 


Asp Ser Thr Val Ser Gly Val Ala Ala Gly Val Pro Arg Val Val Phe 
                485                 490                 495     


Leu Phe Pro Gly Gln Gly Thr Gln Trp Ala Gly Met Gly Ala Asp Leu 
            500                 505                 510         


Leu Glu Ser Ser Pro Val Phe Ala Ala Arg Met Arg Gln Cys Ala Ala 
        515                 520                 525             


Glu Leu Ser Lys Tyr Thr Asp Trp Asp Leu Phe Thr Ala Leu Ser Asp 
    530                 535                 540                 


Pro Ala Leu Leu Asp Arg Val Asp Val Val Gln Pro Val Ser Trp Ala 
545                 550                 555                 560 


Leu Met Val Ser Leu Ala Ala Leu Trp Gln His Cys Gly Val Gln Pro 
                565                 570                 575     


Asp Ala Val Ile Gly His Ser Gln Gly Glu Ile Ala Ala Ala Cys Val 
            580                 585                 590         


Ala Gly Ala Leu Thr Leu Gln Asp Gly Ala Arg Leu Ile Thr Gly Arg 
        595                 600                 605             


Ser Ala Leu Ile Ala His Leu Ser Gly Arg Gly Thr Met Ala Ser Ile 
    610                 615                 620                 


Ala Leu Pro Ala Asp Asp Leu Thr Leu Pro Asp Asp Val Cys Ile Ala 
625                 630                 635                 640 


Ala Val Asn Gly Pro Ala Thr Thr Ile Ile Ala Gly Pro Thr Pro Ala 
                645                 650                 655     


Ile Glu His Leu Leu Ala Thr Tyr Glu Ala Ser Asn Ile His Thr Arg 
            660                 665                 670         


Arg Ile Pro Val Asp Tyr Pro Ser His Thr Pro His Val Glu Asp Leu 
        675                 680                 685             


His Asp Pro Leu Leu Ala Ile Thr Thr His Leu Thr Pro His Thr Pro 
    690                 695                 700                 


Thr Thr Pro Trp Leu Ser Thr Val Asp Asn Thr Trp Ile His Thr Pro 
705                 710                 715                 720 


Pro His Pro Asp Tyr Trp Tyr Arg Asn Leu Arg His Pro Val Gln Leu 
                725                 730                 735     


Ala Pro Ala Ile Thr Thr Leu Thr His Pro His Pro Thr His Leu Ile 
            740                 745                 750         


Glu Ile Ser Thr His Pro Val Leu Leu Pro Ala Ile Asp Thr Thr Thr 
        755                 760                 765             


Thr Leu Thr Thr Thr Ala Thr Leu Arg Arg Asn His Gly Thr Pro His 
    770                 775                 780                 


Gln Leu Leu Thr Ser Leu Ala His Ala His Thr His Gly Ala Thr Ile 
785                 790                 795                 800 


Asn Trp Pro Ala Leu Leu Gly Asn Pro Pro Thr Ala Thr Thr Ala Asp 
                805                 810                 815     


Leu Pro Thr Tyr Pro Phe Gln Arg Arg Arg Phe Trp Ala Glu Arg Ile 
            820                 825                 830         


Ser Gly Leu Glu Pro Ala Glu Arg Gly Gln Ala Leu Leu Glu Ile Val 
        835                 840                 845             


Arg Glu Ala Ala Ala Val Val Leu Gly His Thr Asp Ala Arg Glu Ile 
    850                 855                 860                 


Ala Pro Thr Thr Ala Phe Arg Asp Leu Gly Ile Asp Ser Leu Thr Ala 
865                 870                 875                 880 


Ile Glu Leu Arg Asn Arg Val Ala Thr Glu Thr Gly Leu Arg Leu Pro 
                885                 890                 895     


Ala Thr Leu Val Phe Asp His Pro Thr Pro Thr Thr Leu Ala Thr Trp 
            900                 905                 910         


Ile 
    


<210>  52
<211>  887
<212>  PRT
<213>  Streptomyces hygroscopicus

<400>  52

Glu Pro Leu Ala Ile Val Gly Met Ala Cys Arg Leu Pro Gly Gly Ile 
1               5                   10                  15      


Ser Ser Pro Glu Asp Leu Trp Gln Leu Val Gln Ser Gly Gly Asp Ala 
            20                  25                  30          


Ile Ser Asp Phe Pro Thr Asp Arg Gly Trp Asp Leu Thr His Leu Tyr 
        35                  40                  45              


Asp Asn Asp Ala Pro Pro Val Tyr Arg Gly Gly Phe Leu Thr Asp Ala 
    50                  55                  60                  


Gly Asp Phe Asp Ala Ala Phe Phe Gly Ile Ser Pro Arg Glu Ala Leu 
65                  70                  75                  80  


Ala Met Asp Pro Gln Gln Arg Leu Ile Leu Glu Thr Ser Trp Glu Val 
                85                  90                  95      


Leu Glu Arg Ala Gly Ile Glu Pro Gly Thr Leu Arg Gly Ser Glu Thr 
            100                 105                 110         


Gly Val Phe Val Gly Gly Phe Thr Gln Gly Tyr Gly Thr Gly Ala Asp 
        115                 120                 125             


Leu Gly Gly Phe Gly Met Thr Ser Gly His Ser Ser Val Leu Ser Gly 
    130                 135                 140                 


Arg Val Ser Tyr Phe Phe Gly Phe Glu Gly Pro Ala Val Thr Val Asp 
145                 150                 155                 160 


Thr Ala Cys Ser Ser Ser Leu Val Ala Leu His Gln Ala Ser Ser Ala 
                165                 170                 175     


Leu Arg Gln Gly Glu Cys Ser Leu Ala Leu Val Gly Gly Val Thr Val 
            180                 185                 190         


Met Ala Ser Pro Gln Gly Phe Thr Glu Phe Ser Arg Gln Gly Gly Leu 
        195                 200                 205             


Ser Pro Asp Gly Arg Cys Lys Ala Phe Ala Asp Ala Ala Asp Gly Thr 
    210                 215                 220                 


Gly Trp Ala Glu Gly Val Gly Val Leu Leu Val Glu Arg Leu Ser Asp 
225                 230                 235                 240 


Ala Gln Arg Asn Gly His Thr Val Leu Ala Val Val Arg Gly Ser Ala 
                245                 250                 255     


Val Asn Gln Asp Gly Ala Ser Asn Gly Leu Ser Ala Pro Asn Gly Pro 
            260                 265                 270         


Ser Gln Gln Arg Val Ile Arg Gln Ala Leu Ala Asn Ala Arg Leu Thr 
        275                 280                 285             


Pro Ala Asp Ile Asp Val Val Glu Ala His Gly Thr Gly Thr Thr Leu 
    290                 295                 300                 


Gly Asp Pro Ile Glu Ala Gln Ala Ile Leu Ala Thr Tyr Gly Gln Asp 
305                 310                 315                 320 


Arg Asp Gln Pro Leu Leu Leu Gly Ser Leu Lys Ser Asn Ile Gly His 
                325                 330                 335     


Thr Gln Ala Ala Ala Gly Val Ala Gly Val Ile Lys Met Val Met Ala 
            340                 345                 350         


Met Arg His Gly Thr Ala Pro Arg Thr Leu His Ile Asp Glu Pro Ser 
        355                 360                 365             


Arg His Ile Asp Trp Thr Thr Gly Ser Val Ala Leu Ser Thr Glu Asn 
    370                 375                 380                 


Gln Pro Trp Pro Glu Thr Gly His Pro Arg Arg Ala Gly Val Ser Ala 
385                 390                 395                 400 


Phe Gly Val Ser Gly Thr Asn Ala His Val Val Leu Glu Gly Val Pro 
                405                 410                 415     


Val Ala Gly Pro Pro Glu Glu Asp Val Glu Pro Gly Val Val Pro Leu 
            420                 425                 430         


Leu Ile Ser Ala Lys Ser Arg Pro Ala Leu Met Glu Gln Glu Gln Arg 
        435                 440                 445             


Leu Arg Thr Tyr Leu Asp Gly Ser Gln Thr Asp Ile Arg Ala Val Ala 
    450                 455                 460                 


Ala Thr Leu Ala His Ala Arg Ser Val Phe Glu His Arg Ser Val Leu 
465                 470                 475                 480 


Val Gly Asp Thr Val Val Ser Gly Thr Ala Ala Asp Ala Arg Leu Val 
                485                 490                 495     


Leu Val Phe Ser Gly Gln Gly Ser Gln Arg Ala Gly Met Gly Glu Glu 
            500                 505                 510         


Leu Ala Ala Arg Phe Pro Val Phe Ala Glu Ile His Gln Arg Val Trp 
        515                 520                 525             


Asp Leu Leu Asp Val Gly Pro Gly Leu Asp Val Asp Asp Thr Gly Tyr 
    530                 535                 540                 


Ala Gln Pro Ala Leu Phe Ala Leu Gln Val Ala Leu Phe Gly Leu Leu 
545                 550                 555                 560 


Glu Ser Trp Gly Val Arg Pro Asp Val Leu Ile Gly His Ser Ile Gly 
                565                 570                 575     


Glu Leu Ala Ala Ala Cys Val Ser Gly Val Trp Ser Leu Gln Asp Ala 
            580                 585                 590         


Cys Ala Leu Val Ser Ala Arg Ala Arg Leu Met Gln Ala Leu Pro Ala 
        595                 600                 605             


Gly Gly Val Met Ala Ala Val Pro Val Ser Glu Ala Glu Ala Glu Ala 
    610                 615                 620                 


Val Leu Arg Glu Gly Val Glu Ile Ala Ala Val Asn Gly Pro Ala Ser 
625                 630                 635                 640 


Ile Val Leu Ser Gly Asp Glu Asp Ala Val Leu Gln Ala Ala Ala Ser 
                645                 650                 655     


Leu Gly Arg Phe Thr Arg Leu Ser Thr Ser His Ala Phe His Cys Ala 
            660                 665                 670         


Arg Met Asp Pro Met Leu Asp Glu Phe Arg Gln Val Ala Glu Ser Ile 
        675                 680                 685             


Ala Tyr Gln Pro Pro Arg Ile Ala Met Ala Ala Gly Asp Gln Val Ile 
    690                 695                 700                 


Thr Pro Asp Tyr Trp Val Arg Gln Val Arg Glu Pro Val Arg Phe Gly 
705                 710                 715                 720 


Asp Gln Val Ala Ala His Ala Asp Ala Val Phe Leu Glu Ile Gly Pro 
                725                 730                 735     


Asp Arg Thr Leu Ala Arg Leu Ile Asp Gly Val Pro Leu Leu Ser Lys 
            740                 745                 750         


Glu Asp Glu Val Gln Ala Ala Leu Val Ala Leu Ala Glu Leu His Val 
        755                 760                 765             


Arg Gly Val Pro Leu Glu Trp Ser Thr Val Ile Gly Gly Met Thr Ser 
    770                 775                 780                 


Ile Val Asp Leu Pro Thr Tyr Pro Phe Arg Arg Lys Arg Tyr Trp Ile 
785                 790                 795                 800 


Glu Ser Ala Glu Arg Leu Thr Thr Gln Ser Ser Val Glu Gln His Arg 
                805                 810                 815     


Leu Met Leu Asp Leu Val Thr Ser His Ala Ala Ala Val Leu Gly His 
            820                 825                 830         


Ser Ser Ala Ala Ala Ile Thr Thr Asp Thr Pro Phe Arg Asp Leu Gly 
        835                 840                 845             


Phe Asp Ser Leu Thr Ala Val Glu Leu Arg Asn Arg Val Ala Ala Asp 
    850                 855                 860                 


Thr Gly Leu Arg Leu Pro Ala Thr Leu Val Phe Asn His Pro Asn Ala 
865                 870                 875                 880 


Gly Asp Leu Ala Arg His Leu 
                885         


<210>  53
<211>  923
<212>  PRT
<213>  Streptomyces hygroscopicus

<400>  53

Glu Pro Leu Ala Ile Val Gly Met Ala Cys Arg Leu Pro Gly Gly Ile 
1               5                   10                  15      


Ser Ser Pro Glu Asp Leu Trp Gln Leu Val Gln Ser Gly Gly Asp Ala 
            20                  25                  30          


Ile Thr Asp Leu Pro Thr Asp Arg Gly Trp Asp Leu Thr His Leu Tyr 
        35                  40                  45              


Asp Asn Asp Ala Pro Pro Val Tyr Arg Gly Gly Phe Leu Thr Asp Ala 
    50                  55                  60                  


Gly Asp Phe Asp Ala Ala Phe Phe Gly Ile Ser Pro Arg Glu Ala Leu 
65                  70                  75                  80  


Ala Met Asp Pro Gln Gln Arg Ile Leu Leu Glu Thr Ser Trp Glu Ala 
                85                  90                  95      


Phe Glu Arg Gly Gly Ile Asn Pro Glu Ala Ile Arg Gly Ser Asn Thr 
            100                 105                 110         


Gly Val Phe Ile Gly Gly Phe Ser Tyr Gly Tyr Gly Thr Gly Ala Asp 
        115                 120                 125             


Leu Gly Gly Phe Gly Ala Thr Ser Thr Gln Thr Ser Val Leu Ser Gly 
    130                 135                 140                 


Arg Leu Ser Tyr Phe Tyr Gly Phe Glu Gly Pro Ala Val Thr Val Asp 
145                 150                 155                 160 


Thr Ala Cys Ser Ser Ser Leu Val Ala Leu His Gln Ala Ser Ser Ala 
                165                 170                 175     


Leu Arg Gln Gly Glu Cys Ser Leu Ala Leu Ala Gly Gly Val Thr Val 
            180                 185                 190         


Met Ala Thr Pro Ala Gly Phe Glu Glu Phe Ala Arg Gln Gly Gly Leu 
        195                 200                 205             


Ala Ala Asp Gly Arg Cys Lys Ala Phe Ala Asp Thr Ala Asp Gly Thr 
    210                 215                 220                 


Gly Trp Ala Glu Gly Val Gly Val Leu Leu Val Glu Arg Leu Ser Asp 
225                 230                 235                 240 


Ala Gln Arg Asn Gly His Thr Val Leu Ala Val Val Arg Gly Ser Ala 
                245                 250                 255     


Val Asn Gln Asp Gly Ala Ser Asn Gly Leu Ser Ala Pro Asn Gly Pro 
            260                 265                 270         


Ser Gln Gln Arg Val Ile Arg Gln Ala Leu Ala Asn Ala Arg Leu Thr 
        275                 280                 285             


Pro Ala Asp Ile Asp Val Val Glu Ala His Gly Thr Gly Thr Thr Leu 
    290                 295                 300                 


Gly Asp Pro Ile Glu Ala Gln Ala Ile Leu Ala Thr Tyr Gly Gln Asp 
305                 310                 315                 320 


Arg Asp Gln Pro Leu Leu Leu Gly Ser Leu Lys Ser Asn Ile Gly His 
                325                 330                 335     


Thr Gln Ala Ala Ala Gly Val Ala Gly Ile Ile Lys Thr Val Met Ala 
            340                 345                 350         


Met Arg His Gly Thr Ala Pro Arg Thr Leu His Ala Asp Glu Pro Ser 
        355                 360                 365             


Arg His Val Asp Trp Ser Ala Gly Ala Val Glu Leu Leu Ser Glu Asn 
    370                 375                 380                 


Arg Leu Trp Pro Glu Thr Asp Arg Pro Arg Arg Ala Ala Val Ser Ser 
385                 390                 395                 400 


Phe Gly Val Ser Gly Thr Asn Ala His Val Ile Leu Glu Ser Ala Pro 
                405                 410                 415     


Ala Glu Ser Ala Glu Gly Pro Ala Gly Met Gly Ser Glu Ser Met Gly 
            420                 425                 430         


Ser Glu Ser Gly Pro Val Val Val Val Leu Ser Ala Lys Ser Ala Ser 
        435                 440                 445             


Ala Leu Ala Gly Gln Glu Glu Arg Leu Arg Ala Tyr Leu Ala Ser Gly 
    450                 455                 460                 


Ala Asp Val Arg Ala Val Ala Ala Gly Leu Ala Arg Arg Ser Val Phe 
465                 470                 475                 480 


Glu His Arg Ser Val Ile Leu Gly Asp Ser Thr Val Ser Gly Val Ala 
                485                 490                 495     


Ala Gly Val Pro Arg Val Val Phe Leu Phe Pro Gly Gln Gly Thr Gln 
            500                 505                 510         


Trp Ala Gly Met Gly Ala Asp Leu Leu Glu Ser Ser Pro Val Phe Ala 
        515                 520                 525             


Ala Arg Met Arg Gln Cys Ala Ala Glu Leu Ser Lys Tyr Thr Asp Trp 
    530                 535                 540                 


Asp Leu Phe Thr Ala Leu Ser Asp Pro Ala Leu Leu Asp Arg Val Asp 
545                 550                 555                 560 


Val Val Gln Pro Val Ser Trp Ala Leu Met Val Ser Leu Ala Ala Leu 
                565                 570                 575     


Trp Gln His Cys Gly Val Gln Pro Asp Ala Val Ile Gly His Ser Gln 
            580                 585                 590         


Gly Glu Ile Ala Ala Ala Cys Val Ala Gly Ala Leu Thr Leu Gln Asp 
        595                 600                 605             


Gly Ala Arg Leu Ile Thr Gly Arg Ser Ala Leu Ile Ala His Leu Ser 
    610                 615                 620                 


Gly Arg Gly Thr Met Ala Ser Ile Ala Leu Pro Ala Asp Asp Leu Thr 
625                 630                 635                 640 


Leu Pro Asp Asp Val Cys Ile Ala Ala Val Asn Gly Pro Ala Thr Thr 
                645                 650                 655     


Ile Ile Ala Gly Pro Thr Pro Ala Ile Glu His Leu Leu Ala Thr Tyr 
            660                 665                 670         


Glu Ala Ser Asn Ile His Thr Arg Arg Ile Pro Val Asp Tyr Pro Ser 
        675                 680                 685             


His Thr Pro His Val Glu Asp Leu His Asp Pro Leu Leu Ala Ile Thr 
    690                 695                 700                 


Thr His Leu Thr Pro His Thr Pro Thr Thr Pro Trp Leu Ser Thr Val 
705                 710                 715                 720 


Asp Asn Thr Trp Ile His Thr Pro Pro His Pro Asp Tyr Trp Tyr Arg 
                725                 730                 735     


Asn Leu Arg His Pro Val Gln Leu Ala Pro Ala Ile Thr Thr Leu Thr 
            740                 745                 750         


His Pro His Pro Thr His Leu Ile Glu Ile Ser Thr His Pro Val Leu 
        755                 760                 765             


Leu Pro Ala Ile Asp Thr Thr Thr Thr Leu Thr Thr Thr Ala Thr Leu 
    770                 775                 780                 


Arg Arg Asn His Gly Thr Pro His Gln Leu Leu Thr Ser Leu Ala His 
785                 790                 795                 800 


Ala His Thr His Gly Ala Thr Ile Asn Trp Pro Ala Leu Leu Gly Asn 
                805                 810                 815     


Pro Pro Thr Ala Thr Thr Ala Asp Leu Pro Thr Tyr Pro Phe Gln His 
            820                 825                 830         


Lys Arg Tyr Trp Leu Gln Asp Thr Arg Leu Ser Ala Leu Ala Pro Ala 
        835                 840                 845             


Glu Arg Glu Gln Ala Leu Val Lys Ala Val Cys Glu Thr Ala Ala Met 
    850                 855                 860                 


Val Leu Gly His Ala Asp Thr Arg Glu Ile Ala Ala Thr Thr Ala Phe 
865                 870                 875                 880 


Lys Glu Leu Gly Leu Asp Ser Leu Thr Ala Val Gln Leu Arg Asp Arg 
                885                 890                 895     


Leu Ala Ala Glu Thr Gly Arg Lys Leu Pro Ala Thr Leu Val Phe Asp 
            900                 905                 910         


Tyr Pro Ser Pro Gln Ala Leu Ala Ala Trp Leu 
        915                 920             


<210>  54
<211>  884
<212>  PRT
<213>  Actinoplanes sp.

<400>  54

Glu Pro Leu Ala Ile Val Gly Met Ala Cys Arg Leu Pro Gly Gly Val 
1               5                   10                  15      


Ala Ser Pro Glu Asp Leu Trp Arg Leu Val Glu Ser Gly Thr Asp Ala 
            20                  25                  30          


Ile Thr Asp Phe Pro Thr Asp Arg Gly Trp Asp Leu Asp Glu Val Ala 
        35                  40                  45              


Asp Gln Ser Tyr Cys Leu Gln Gly Gly Phe Leu Asp Asn Ala Ala Gly 
    50                  55                  60                  


Phe Asp Ala Ala Phe Phe Gly Ile Ser Pro Arg Glu Ala Leu Ala Met 
65                  70                  75                  80  


Asp Pro Gln Gln Arg Leu Val Leu Glu Ala Ser Trp Glu Ala Phe Glu 
                85                  90                  95      


Arg Ala Gly Ile Lys Pro Gly Ser Leu Arg Gly Ser Asp Thr Gly Val 
            100                 105                 110         


Phe Met Gly Ala Tyr Pro Gly Gly Tyr Gly Thr Gly Ala Asp Leu Gly 
        115                 120                 125             


Gly Phe Gly Ala Thr Ala Gly Ala Val Ser Val Leu Ser Gly Arg Ile 
    130                 135                 140                 


Ser Tyr Phe Phe Gly Phe Glu Gly Pro Ala Met Thr Val Asp Thr Ala 
145                 150                 155                 160 


Cys Ser Ser Ser Leu Val Ala Leu His Gln Ala Gly Tyr Ala Leu Arg 
                165                 170                 175     


Gln Gly Glu Cys Ser Ile Ala Leu Val Gly Gly Val Thr Val Met Ala 
            180                 185                 190         


Thr Pro Gln Ser Phe Ile Glu Phe Ser Arg Gln Arg Gly Leu Ala Ala 
        195                 200                 205             


Asp Gly Arg Cys Lys Thr Phe Ala Asp Ala Ala Asp Gly Thr Gly Trp 
    210                 215                 220                 


Ala Glu Gly Val Gly Val Leu Leu Val Glu Arg Leu Ser Asp Ala Arg 
225                 230                 235                 240 


Ala Lys Gly His Gln Ile Leu Ala Val Val Arg Gly Ser Ala Val Asn 
                245                 250                 255     


Gln Asp Gly Ala Ser Asn Gly Leu Ser Ala Pro Asn Gly Pro Ser Gln 
            260                 265                 270         


Gln Arg Val Ile Arg Gln Ala Leu Val Asn Ala Gly Leu Ser Pro Ala 
        275                 280                 285             


Asp Val Asp Val Val Glu Ala His Gly Thr Gly Thr Thr Leu Gly Asp 
    290                 295                 300                 


Pro Ile Glu Ala Gln Ala Leu Leu Thr Thr Tyr Gly Gln Gly Arg Ser 
305                 310                 315                 320 


Val Pro Leu Leu Leu Gly Ser Val Lys Ser Asn Leu Gly His Thr Gln 
                325                 330                 335     


Ala Ala Ala Gly Val Thr Gly Val Ile Lys Met Val Met Ala Leu Arg 
            340                 345                 350         


His Gly Val Val Pro Arg Thr Leu His Val Asp Glu Pro Ser Arg His 
        355                 360                 365             


Val Asp Trp Ser Ala Gly Ala Val Glu Leu Val Thr Ser Asn Arg Glu 
    370                 375                 380                 


Trp Pro Val Val Asp Arg Pro Gly Arg Ala Gly Val Ser Ser Phe Gly 
385                 390                 395                 400 


Ile Ser Gly Thr Asn Ala His Val Ile Leu Glu Ala Val Pro Ser Asp 
                405                 410                 415     


Thr Pro Ala Ser Thr Ser Thr Asp Ala Val Leu Pro Leu Val Val Ser 
            420                 425                 430         


Ala Arg Thr Ala Pro Ala Ala Glu Asp Leu Thr Ala Arg Leu Arg Ala 
        435                 440                 445             


Tyr Leu Ser Ala Ala Pro Glu Thr Asp Gln Arg Ala Ala Ala Ala Thr 
    450                 455                 460                 


Leu Ala Leu Thr Arg Ser Val Phe Glu His Arg Ala Val Val Leu Gly 
465                 470                 475                 480 


Asp Glu Leu Val Ser Gly Gln Ala Val Arg Asp Pro Arg Val Val Phe 
                485                 490                 495     


Val Phe Ser Gly Gln Gly Ser Gln Arg Ala Gly Met Gly Glu Gln Leu 
            500                 505                 510         


Ala Ala Val Phe Pro Val Phe Ala Glu Ile His Glu Arg Val Trp Ala 
        515                 520                 525             


Leu Leu Asp Val Pro Asp Gly Leu Asp Val Asp Asp Thr Gly His Ala 
    530                 535                 540                 


Gln Pro Ala Leu Phe Ala Leu Gln Val Ala Leu Ser Gly Leu Leu Glu 
545                 550                 555                 560 


Ser Trp Gly Val Arg Pro Ala Ala Val Ile Gly His Ser Ile Gly Glu 
                565                 570                 575     


Leu Ala Ala Ala Tyr Val Ser Gly Val Trp Ser Leu Glu Asp Ala Cys 
            580                 585                 590         


Ala Leu Val Ser Ala Arg Ala Arg Leu Met Gln Ala Leu Pro Pro Gly 
        595                 600                 605             


Gly Val Met Val Ala Val Pro Val Pro Glu Ala Glu Ala Arg Ala Val 
    610                 615                 620                 


Leu Arg Asp Gly Val Glu Ile Ala Ala Val Asn Gly Pro Ser Ser Val 
625                 630                 635                 640 


Val Leu Ser Gly Asp Glu Asp Ala Val Leu Gln Ala Val Ser Gly Phe 
                645                 650                 655     


Ala Lys Trp Thr Arg Leu Lys Thr Ser His Ala Phe His Ser Ala His 
            660                 665                 670         


Met Asp Pro Met Leu Asp Glu Phe Arg Ala Val Ala Glu Arg Leu Thr 
        675                 680                 685             


Tyr Arg Arg Pro Ser Val Glu Met Ala Ala Gly Asp Arg Val Thr Thr 
    690                 695                 700                 


Ala Glu Tyr Trp Val Arg Gln Val Arg Glu Ala Val Arg Phe Gly Asp 
705                 710                 715                 720 


Gln Thr Thr Ala Tyr Glu Asp Ala Val Phe Val Glu Ile Gly Pro Gly 
                725                 730                 735     


Arg Thr Leu Ala Arg Leu Ile Asp Gly Ile Thr Met Leu His Gly Asp 
            740                 745                 750         


Thr Glu Arg Glu Ala Ala Leu Thr Gly Leu Ser Gln Leu Phe Val Arg 
        755                 760                 765             


Gly Val Asp Val Asp Trp Ala Thr Val Ile Glu Asp Thr Thr Ala Arg 
    770                 775                 780                 


Ile Leu Asp Leu Pro Thr Tyr Ala Phe Gln His Glu Asn Tyr Trp Leu 
785                 790                 795                 800 


His Trp Leu Ser Gly Leu Thr Pro Ala Glu Arg Glu Gln Ala Leu Leu 
                805                 810                 815     


Thr Ala Val Arg Glu Asn Ala Ala Ala Val Leu Gly His Ala Asp Ala 
            820                 825                 830         


Arg Thr Val Pro Val Asn Ser Ala Phe Arg Asp Leu Gly Phe Asp Ser 
        835                 840                 845             


Leu Thr Ala Ile Glu Leu Arg Asn Ser Leu Ala Lys Ala Thr Gly Leu 
    850                 855                 860                 


Ser Leu Pro Ala Thr Met Ala Phe Asp Tyr Pro Thr Pro Ala Val Leu 
865                 870                 875                 880 


Ala Thr Arg Leu 
                


<210>  55
<211>  906
<212>  PRT
<213>  Actinoplanes sp.

<400>  55

Glu Pro Leu Ala Ile Val Gly Met Ala Cys Arg Leu Pro Gly Gly Val 
1               5                   10                  15      


Ser Ser Pro Glu Glu Leu Trp Arg Leu Val Glu Ser Gly Val Asp Ala 
            20                  25                  30          


Ile Ser Gly Phe Pro Val Asp Arg Gly Trp Asp Val Glu Asn Leu Phe 
        35                  40                  45              


Asp Pro Asp Pro Asp Ala Ala Gly Lys Ser Tyr Cys Val Gln Gly Gly 
    50                  55                  60                  


Phe Leu Asp Ser Ala Ala Glu Phe Asp Ala Ala Phe Phe Gly Ile Ser 
65                  70                  75                  80  


Pro Arg Glu Ala Leu Ala Met Asp Pro Gln Gln Arg Leu Val Leu Glu 
                85                  90                  95      


Thr Ser Trp Glu Ala Phe Glu Arg Ala Gly Ile Glu Pro Gly Ser Ile 
            100                 105                 110         


Lys Gly Ser Asp Thr Gly Val Phe Met Gly Ala Tyr Gln Gly Gly Tyr 
        115                 120                 125             


Gly Ser Gly Ala Asp Leu Gly Gly Phe Gly Ala Thr Ala Gly Ala Thr 
    130                 135                 140                 


Ser Val Leu Ser Gly Arg Val Ser Tyr Phe Phe Gly Phe Glu Gly Pro 
145                 150                 155                 160 


Ala Met Thr Val Asp Thr Ala Cys Ser Ser Ser Leu Val Ala Leu His 
                165                 170                 175     


Gln Ala Gly Tyr Ala Leu Arg Gln Gly Glu Cys Ser Leu Ala Leu Val 
            180                 185                 190         


Gly Gly Val Thr Val Met Ala Thr Pro Gln Ser Phe Val Glu Phe Ser 
        195                 200                 205             


Arg Gln Arg Gly Leu Ala Val Asp Gly Arg Ser Lys Ala Phe Ala Asp 
    210                 215                 220                 


Ala Ala Asp Gly Thr Gly Trp Ala Glu Gly Val Gly Val Leu Leu Val 
225                 230                 235                 240 


Glu Arg Leu Ser Asp Ala Gln Ala Lys Gly His Gln Ile Leu Ala Val 
                245                 250                 255     


Val Arg Gly Ser Ala Val Asn Gln Asp Gly Ala Ser Asn Gly Leu Ser 
            260                 265                 270         


Ala Pro Asn Gly Pro Ser Gln Gln Arg Val Ile Arg Gln Ala Leu Ala 
        275                 280                 285             


Asn Ala Ser Leu Thr Pro Ala Asp Val Asp Val Val Glu Ala His Gly 
    290                 295                 300                 


Thr Gly Thr Thr Leu Gly Asp Pro Ile Glu Ala Gln Ala Val Ile Ala 
305                 310                 315                 320 


Thr Tyr Gly Gln Asp Arg Ser Thr Pro Leu Leu Leu Gly Ser Leu Lys 
                325                 330                 335     


Ser Asn Ile Gly His Thr Gln Ala Ala Ala Gly Val Ser Gly Val Ile 
            340                 345                 350         


Lys Met Val Met Ala Leu Arg His Gly Val Val Pro Gln Thr Leu His 
        355                 360                 365             


Val Asp Gln Pro Ser Arg His Val Asp Trp Ser Ala Gly Ala Val Glu 
    370                 375                 380                 


Leu Leu Thr Ser Asn Gln Pro Trp Pro Ser Ser Glu Arg Ala Arg Arg 
385                 390                 395                 400 


Ala Gly Val Ser Ala Phe Gly Val Ser Gly Thr Asn Ala His Val Ile 
                405                 410                 415     


Leu Glu Ser Ala Pro Ala Glu Pro Val Val Ala Glu Ala Gly Pro Val 
            420                 425                 430         


Pro Val Val Ser Asp Val Leu Pro Leu Val Leu Ser Ala Lys Ser Ala 
        435                 440                 445             


Pro Ala Leu Arg Ala Leu Glu Gln Arg Leu Arg Ala Tyr Asp Gly Ala 
    450                 455                 460                 


Ala Gly Arg Ala Leu Ala Thr Ala Arg Ala Thr Phe Asp His Arg Ala 
465                 470                 475                 480 


Val Leu Ile Gly Asp Asp Thr Val Thr Gly Val Ala Val Pro Asp Pro 
                485                 490                 495     


Arg Val Val Phe Val Phe Pro Gly Gln Gly Trp Gln Trp Leu Gly Met 
            500                 505                 510         


Gly Arg Glu Leu Arg Gly Ser Ser Val Val Phe Ala Glu Arg Met Ala 
        515                 520                 525             


Glu Cys Ala Ala Ala Leu Ser Glu Phe Val Asp Trp Asp Leu Phe Ala 
    530                 535                 540                 


Ala Leu Asp Asp Pro Ala Val Val Asp Arg Val Asp Val Val Gln Pro 
545                 550                 555                 560 


Val Cys Trp Ala Val Met Val Ser Leu Ala Ala Val Trp Gln Ala Ala 
                565                 570                 575     


Gly Val Asn Pro Asp Ala Val Val Gly His Ser Gln Gly Glu Ile Ala 
            580                 585                 590         


Ala Ala Val Val Ala Gly Ser Leu Ser Leu Arg Asp Gly Ala Arg Val 
        595                 600                 605             


Val Ala Leu Arg Ser Gln Leu Ile Lys Gly Leu Ala Gly Arg Gly Ala 
    610                 615                 620                 


Met Ala Ser Ile Ala Leu Pro Ala Asp Gln Ile Gly Leu Val Glu Gly 
625                 630                 635                 640 


Ala Trp Ile Ala Ala Leu Asn Gly Pro Ser Ser Thr Val Ile Ala Gly 
                645                 650                 655     


Thr Pro Glu Ala Val Glu Gln Val Leu Ala Ala Gln Asp Ala Arg Val 
            660                 665                 670         


Arg Arg Ile Ala Val Asp Tyr Ala Ser His Thr Pro Gln Val Glu Ala 
        675                 680                 685             


Ile Arg Asp Glu Leu Leu Glu Leu Thr Ala Gly Val Ser Ser Gln Pro 
    690                 695                 700                 


Pro Thr Val Pro Trp Leu Ser Thr Val Asp Asn Thr Trp Val Glu Gly 
705                 710                 715                 720 


Pro Leu Pro Ala Asp Tyr Trp Phe Arg Asn Leu Arg Glu Gln Val Gly 
                725                 730                 735     


Phe Ala Gln Ala Val Val Thr Leu Gly Asp Ala Val Phe Val Glu Val 
            740                 745                 750         


Ser Gly Ser Pro Val Leu Met Gln Ser Met Gly Asp Ala Val Thr Val 
        755                 760                 765             


Ala Ser Phe Arg Arg Asp Asp Gly Ser Ala Thr Arg Met Val Thr Ser 
    770                 775                 780                 


Leu Ala Glu Ala Tyr Val Gln Gly Val Asn Val Asn Trp Ala Ala Val 
785                 790                 795                 800 


Leu Gly Ala Gly Thr Glu Arg Ala Leu Asp Leu Pro Thr Tyr Pro Phe 
                805                 810                 815     


Gln Arg Gln His Tyr Trp Ile Ser Leu Ala Ala Leu Pro Pro Ala Glu 
            820                 825                 830         


Arg Glu Arg Ala Leu Leu Lys Val Val Arg Asp Ser Ala Ala Val Val 
        835                 840                 845             


Leu Gly His Ala Asp Gly Arg Thr Val Pro Ala Thr Ala Ala Phe Lys 
    850                 855                 860                 


Asp Leu Gly Leu Asp Ser Leu Thr Ala Val Glu Leu Arg Asn Ser Leu 
865                 870                 875                 880 


Arg Lys Ala Thr Gly Leu Gln Leu Pro Ala Thr Leu Val Phe Asp Tyr 
                885                 890                 895     


Pro Ser Pro Val Ala Leu Ala Ala Arg Leu 
            900                 905     


<210>  56
<211>  911
<212>  PRT
<213>  Actinoplanes sp.

<400>  56

Glu Pro Leu Ala Ile Val Gly Met Ser Cys Arg Leu Pro Gly Gly Val 
1               5                   10                  15      


Ser Ser Pro Glu Asp Leu Trp Arg Leu Val Glu Ser Gly Val Asp Ala 
            20                  25                  30          


Ile Ser Gly Phe Pro Val Asp Arg Gly Trp Asp Ala Glu Gly Leu Phe 
        35                  40                  45              


Asp Pro Asp Pro Asp Ala Ala Gly Lys Thr Tyr Cys Val Gln Gly Gly 
    50                  55                  60                  


Phe Leu Glu Ala Ala Gly Glu Phe Asp Thr Ala Phe Phe Gly Ile Ser 
65                  70                  75                  80  


Pro Arg Glu Ala Leu Ala Met Asp Pro Gln Gln Arg Val Leu Leu Glu 
                85                  90                  95      


Ala Ser Trp Glu Ala Phe Glu Arg Ala Gly Ile Gly Ala Asp Thr Val 
            100                 105                 110         


Arg Gly Thr Asp Thr Gly Val Phe Ile Gly Ala Tyr Pro Val Ala Tyr 
        115                 120                 125             


Gly Ala Gly Val Asp Arg Glu Gly Tyr Gly Ala Thr Ala Ala Pro Asn 
    130                 135                 140                 


Val Leu Ser Gly Arg Leu Ser Tyr Phe Phe Gly Leu Glu Gly Pro Ala 
145                 150                 155                 160 


Ile Thr Val Asp Thr Ala Cys Ser Ser Ser Leu Val Ala Leu His Leu 
                165                 170                 175     


Ala Ala Ser Ala Leu Arg Asn Gly Glu Cys Ser Leu Ala Leu Ala Gly 
            180                 185                 190         


Gly Val Thr Val Met Ala Thr Pro Glu Val Phe Thr Glu Phe Ala Arg 
        195                 200                 205             


Gln Arg Gly Leu Ala Phe Asp Gly Arg Ser Lys Ser Phe Ala Asp Ala 
    210                 215                 220                 


Ala Asp Gly Ala Gly Phe Ser Glu Gly Ala Gly Leu Leu Val Leu Glu 
225                 230                 235                 240 


Arg Leu Ser Asp Ala Arg Arg Asn Gly His Gln Val Leu Ala Val Ile 
                245                 250                 255     


Arg Gly Ser Ala Val Asn Gln Asp Gly Ala Ser Asn Gly Phe Thr Ala 
            260                 265                 270         


Pro Asn Gly Pro Ser Gln Gln Arg Val Ile Glu Ala Ala Leu Gly Asn 
        275                 280                 285             


Ala Gly Leu Thr Thr Ala Glu Val Asp Val Val Glu Ala His Gly Thr 
    290                 295                 300                 


Gly Thr Lys Leu Gly Asp Pro Ile Glu Ala Gln Ala Val Leu Ala Thr 
305                 310                 315                 320 


Tyr Gly Gln Asp Arg Asp Leu Pro Leu Leu Leu Gly Ser Leu Lys Ser 
                325                 330                 335     


Asn Ile Gly His Thr Gln Ala Ala Ser Gly Val Ala Gly Val Ile Lys 
            340                 345                 350         


Met Val Met Ala Leu Arg His Gly Val Val Pro Gln Thr Leu His Val 
        355                 360                 365             


Asp Glu Pro Ser Arg His Val Asp Trp Ser Ala Gly Ala Val Glu Leu 
    370                 375                 380                 


Val Thr Ser Asn Gln Pro Trp Pro Ser Ser Glu Arg Pro Arg Arg Ala 
385                 390                 395                 400 


Gly Val Ser Ala Phe Gly Val Ser Gly Thr Asn Ala His Val Ile Leu 
                405                 410                 415     


Glu Ser Ala Pro Val Glu Pro Val Val Ala Glu Ala Gly Pro Val Pro 
            420                 425                 430         


Val Val Gly Asp Val Leu Pro Leu Val Val Ser Ala Lys Ser Ala Pro 
        435                 440                 445             


Ala Leu Thr Val Leu Glu Gln Arg Leu Arg Ala Tyr Glu Ala Ala Asp 
    450                 455                 460                 


Glu Lys Ala Val Ala Ala Thr Leu Ala Ala Ala Arg Ala Thr Phe Gly 
465                 470                 475                 480 


His Arg Ala Val Leu Leu Gly Gly Asp Thr Val Thr Gly Val Ala Val 
                485                 490                 495     


Pro Asp Pro Arg Val Val Phe Val Phe Pro Gly Gln Gly Trp Gln Trp 
            500                 505                 510         


Leu Gly Met Gly Arg Glu Leu Arg Gly Ser Ser Val Val Phe Ala Glu 
        515                 520                 525             


Arg Met Ala Glu Cys Ala Ala Ala Leu Ser Glu Phe Val Asp Trp Asp 
    530                 535                 540                 


Leu Phe Thr Ala Leu Asp Asp Pro Ala Val Val Asp Arg Val Asp Val 
545                 550                 555                 560 


Val Gln Pro Val Cys Trp Ala Val Met Val Ser Leu Ala Ala Val Trp 
                565                 570                 575     


Gln Ala Ser Gly Val Asn Pro Asp Ala Val Val Gly His Ser Gln Gly 
            580                 585                 590         


Glu Ile Ala Ala Ala Val Val Ala Gly Ser Leu Ser Leu Arg Asp Gly 
        595                 600                 605             


Ala Arg Val Val Ala Leu Arg Ser Gln Leu Ile Lys Gly Leu Ala Gly 
    610                 615                 620                 


Arg Gly Ala Met Ala Ser Ile Ala Leu Pro Ala Ala Glu Ile Asp Leu 
625                 630                 635                 640 


Val Glu Gly Ser Trp Ile Ala Ala Leu Asn Gly Pro Ser Ser Thr Val 
                645                 650                 655     


Ile Ala Gly Thr Pro Glu Ala Val Glu Gln Val Leu Ala Val Gln Asp 
            660                 665                 670         


Ala Arg Val Arg Arg Ile Ala Val Asp Tyr Ala Ser His Thr Pro Gln 
        675                 680                 685             


Val Glu Ala Ile Arg Asp Glu Leu Leu Glu Leu Thr Gly Glu Val Val 
    690                 695                 700                 


Ser Arg Lys Pro Asp Val Pro Trp Leu Ser Thr Val Asp Asn Ala Trp 
705                 710                 715                 720 


Ile Glu Gly Pro Leu Gly Ala Asp Tyr Trp Phe Arg Asn Leu Arg Glu 
                725                 730                 735     


Gln Val Gly Phe Ala Gln Ala Val Val Thr Leu Gly Asp Ala Val Phe 
            740                 745                 750         


Val Glu Val Ser Ala Ser Pro Val Leu Met Gln Ser Met Gly Asp Ala 
        755                 760                 765             


Val Cys Val Pro Ser Leu Arg Arg Asp Asp Gly Thr Ala Thr Arg Met 
    770                 775                 780                 


Val Thr Ser Leu Ala Glu Ala Tyr Val Gln Gly Val Gln Val Asn Trp 
785                 790                 795                 800 


Ala Ala Val Leu Gly Ala Gly Thr Glu Arg Ala Leu Asp Leu Pro Thr 
                805                 810                 815     


Tyr Pro Phe Gln Arg Gln His Tyr Trp Ala Leu His Trp Leu Ala Arg 
            820                 825                 830         


Leu Ser Pro Ala Glu Arg Glu Gln Ala Leu Leu Lys Leu Val Cys Glu 
        835                 840                 845             


Ser Ala Ser Val Val Leu Gly His Ala Asp Ala Gly Ala Ile Pro Val 
    850                 855                 860                 


Thr Ala Ala Phe Lys Asp Leu Gly Val Asp Ser Leu Thr Ala Val Glu 
865                 870                 875                 880 


Leu Arg Asn Ser Leu Ala Thr Ala Thr Gly Gln Arg Leu Pro Ala Thr 
                885                 890                 895     


Ala Val Phe Asp Tyr Pro Thr Pro Ala Val Leu Ala Ala Arg Leu 
            900                 905                 910     


<210>  57
<211>  879
<212>  PRT
<213>  Actinoplanes sp.

<400>  57

Glu Pro Leu Ala Ile Val Gly Met Ala Cys Arg Leu Pro Gly Gly Val 
1               5                   10                  15      


Ser Ser Pro Glu Gly Leu Trp Arg Leu Val Val Ser Gly Ser Asp Val 
            20                  25                  30          


Ile Ser Gly Phe Pro Ala Asp Arg Gly Trp Gly Val Glu Gly Leu Arg 
        35                  40                  45              


Gly Gly Phe Leu Pro Gly Ala Ala Asp Phe Asp Ala Gly Phe Phe Gly 
    50                  55                  60                  


Ile Ser Pro Arg Glu Ala Leu Ala Met Asp Pro Gln Gln Arg Leu Val 
65                  70                  75                  80  


Leu Glu Ala Ser Trp Glu Val Leu Glu Arg Ala Gly Ile Ala Pro Gly 
                85                  90                  95      


Ser Leu Arg Gly Ser Asp Thr Gly Val Phe Met Gly Ala Tyr Pro Gly 
            100                 105                 110         


Gly Tyr Gly Ile Gly Ala Asp Leu Gly Gly Phe Gly Ala Thr Ala Gly 
        115                 120                 125             


Ala Val Ser Val Leu Ser Gly Arg Val Ser Tyr Phe Phe Gly Phe Glu 
    130                 135                 140                 


Gly Pro Ala Met Thr Val Asp Thr Ala Cys Ser Ser Ser Leu Val Ala 
145                 150                 155                 160 


Leu His Gln Ala Gly His Ala Leu Arg Asn Ser Glu Cys Ser Leu Ala 
                165                 170                 175     


Leu Val Gly Gly Val Thr Val Met Ala Ser Pro Gln Thr Phe Val Glu 
            180                 185                 190         


Phe Glu Arg Gln Gly Gly Leu Ala Ala Asp Gly Arg Ser Lys Ala Phe 
        195                 200                 205             


Ser Asp Gly Ala Asp Gly Ala Gly Phe Ser Glu Gly Val Gly Val Leu 
    210                 215                 220                 


Leu Val Glu Arg Leu Ser Asp Ala Arg Ala Lys Gly His Gln Ile Leu 
225                 230                 235                 240 


Ala Leu Val Arg Gly Ser Ala Val Asn Gln Asp Gly Ala Ser Asn Gly 
                245                 250                 255     


Leu Thr Ala Pro Asn Gly Pro Ser Gln Gln Arg Val Ile Arg Gln Ala 
            260                 265                 270         


Leu Ala Asn Ala Ser Leu Thr Val Ala Asp Val Asp Val Val Glu Ala 
        275                 280                 285             


His Gly Thr Gly Thr Thr Leu Gly Asp Pro Ile Glu Ala Gln Ala Leu 
    290                 295                 300                 


Leu Ala Thr Tyr Gly Gln Asp Arg Asp Arg Pro Leu Leu Leu Gly Ser 
305                 310                 315                 320 


Val Lys Ser Asn Leu Gly His Thr Gln Ala Ala Ala Gly Val Thr Gly 
                325                 330                 335     


Val Ile Lys Met Val Met Ala Leu Arg His Gly Val Val Pro Arg Thr 
            340                 345                 350         


Leu His Val Asp Glu Pro Ser Arg His Val Asp Trp Ser Ala Gly Ala 
        355                 360                 365             


Val Glu Leu Val Thr Ser Asn Arg Glu Trp Pro Val Thr Asp Arg Pro 
    370                 375                 380                 


Gly Arg Ala Gly Val Ser Ser Phe Gly Ile Ser Gly Thr Asn Ala His 
385                 390                 395                 400 


Val Ile Leu Glu Ala Val Pro Val Val Ser Ala Val Ser Thr Gly Gly 
                405                 410                 415     


Glu Val Gln Pro Leu Val Val Ser Ala Arg Thr Ala Pro Ala Ala Glu 
            420                 425                 430         


Asp Leu Thr Ala Arg Leu Arg Thr Tyr Leu Ala Asp Thr Pro Asp Thr 
        435                 440                 445             


Asp Gln Arg Ala Ala Ala Thr Thr Leu Ala Leu Thr Arg Ser Val Phe 
    450                 455                 460                 


Glu His Arg Ala Val Leu Leu Gly Asp Asp Thr Ile Thr Gly Ala Ala 
465                 470                 475                 480 


Val Pro Asp Pro Arg Val Val Phe Val Phe Ser Gly Gln Gly Ser Gln 
                485                 490                 495     


Arg Ala Gly Met Gly Glu Gln Leu Ala Ala Ala Phe Pro Val Phe Ala 
            500                 505                 510         


Glu Ile His Glu Arg Val Trp Ala Leu Leu Asp Val Pro Asp Gly Leu 
        515                 520                 525             


Asp Val Asp Asp Thr Gly His Ala Gln Pro Ala Leu Phe Ala Leu Gln 
    530                 535                 540                 


Val Ala Leu Ser Gly Leu Leu Glu Ser Trp Gly Val Arg Pro Ala Ala 
545                 550                 555                 560 


Val Ile Gly His Ser Ile Gly Glu Leu Ala Ala Ala Tyr Val Ser Gly 
                565                 570                 575     


Val Trp Ser Leu Glu Asp Ala Cys Val Leu Val Ser Ala Arg Ala Arg 
            580                 585                 590         


Leu Met Gln Ala Leu Pro Pro Gly Gly Val Met Val Ala Val Pro Val 
        595                 600                 605             


Pro Glu Ala Glu Ala Arg Ala Val Leu Arg Asp Gly Val Glu Ile Ala 
    610                 615                 620                 


Ala Val Asn Gly Pro Ser Ser Val Val Leu Ser Gly Asp Glu Asp Ala 
625                 630                 635                 640 


Val Leu Gln Ala Val Ala Gly Phe Ala Lys Trp Thr Arg Leu Lys Thr 
                645                 650                 655     


Ser His Ala Phe His Ser Ala His Met Asp Pro Met Leu Asp Glu Phe 
            660                 665                 670         


Arg Ala Val Ala Glu Arg Leu Thr Tyr Arg Arg Pro Ser Val Glu Met 
        675                 680                 685             


Ala Ala Gly His Gly Val Thr Thr Ala Glu Tyr Trp Val Arg Gln Val 
    690                 695                 700                 


Arg Glu Ala Val Arg Phe Gly Asp Gln Thr Thr Ala Tyr Glu Asp Ala 
705                 710                 715                 720 


Val Phe Val Glu Ile Gly Pro Gly Arg Thr Leu Ala Arg Leu Ile Asp 
                725                 730                 735     


Gly Ile Thr Met Leu His Gly Asp Thr Glu Arg Glu Ala Ala Leu Thr 
            740                 745                 750         


Gly Leu Ser Gln Leu Phe Val Arg Gly Val Asp Val Asp Trp Pro Ala 
        755                 760                 765             


Val Ile Glu Asp Thr Thr Ala Arg Ile Leu Asp Leu Pro Thr Tyr Pro 
    770                 775                 780                 


Phe Gln Arg Gln Arg Tyr Trp Leu Thr Pro Arg Trp Leu Ala Gly Met 
785                 790                 795                 800 


Ser Pro Glu Asp Arg Arg Gln Ala Leu Leu Arg Val Val Arg Asp Ser 
                805                 810                 815     


Ala Ala Val Val Leu Gly His Ala Glu Ala Gly Thr Ile Pro Pro Asn 
            820                 825                 830         


Ala Ala Phe Lys Asp Leu Gly Ile Asp Ser Leu Thr Ala Val Glu Leu 
        835                 840                 845             


Arg Asn Ser Leu Ala Thr Ala Thr Gly Leu Arg Leu Pro Ala Thr Leu 
    850                 855                 860                 


Val Phe Asp Tyr Pro Ala Pro Glu Thr Leu Ala Ala Arg Leu Asp 
865                 870                 875                 


<210>  58
<211>  892
<212>  PRT
<213>  Actinoplanes sp.

<400>  58

Glu Pro Leu Ala Ile Val Gly Met Ala Cys Arg Leu Pro Gly Gly Val 
1               5                   10                  15      


Ala Ser Pro Glu Asp Leu Trp Arg Leu Val Ala Ser Gly Thr Asp Ala 
            20                  25                  30          


Ile Ser Gly Phe Pro Thr Asp Arg Gly Trp Asp Val Glu Gly Leu Phe 
        35                  40                  45              


Asp Pro Asp Pro Asp Val Ala Gly Lys Thr Tyr Cys Val Gln Gly Gly 
    50                  55                  60                  


Phe Leu Asp Thr Ala Ala Arg Phe Asp Ala Ala Phe Phe Gly Ile Ser 
65                  70                  75                  80  


Pro Arg Glu Ala Leu Ala Met Asp Pro Gln Gln Arg Leu Val Leu Glu 
                85                  90                  95      


Ala Ser Trp Glu Ala Phe Glu Arg Ala Gly Ile Glu Pro Gly Ser Leu 
            100                 105                 110         


Arg Gly Ser Asp Thr Gly Val Phe Met Gly Ala Phe Pro Gly Gly Tyr 
        115                 120                 125             


Gly Leu Gly Ala Asp Leu Glu Gly Tyr Gly Val Thr Gly Gly Pro Asn 
    130                 135                 140                 


Ala Val Ser Gly Arg Leu Ser Tyr Phe Phe Gly Leu Glu Gly Pro Ala 
145                 150                 155                 160 


Phe Thr Val Asp Thr Ala Cys Ser Ser Ser Leu Val Ala Leu His Gln 
                165                 170                 175     


Ala Gly Tyr Ala Leu Arg Gln Gly Glu Cys Ser Leu Ala Leu Val Gly 
            180                 185                 190         


Gly Val Thr Val Met Gly Thr Pro Gln Thr Phe Val Glu Phe Ser Arg 
        195                 200                 205             


Gln Arg Gly Leu Ala Val Asp Gly Arg Ser Lys Ser Phe Ser Asp Gln 
    210                 215                 220                 


Ala Asp Gly Thr Gly Trp Ser Glu Gly Val Gly Val Leu Val Val Glu 
225                 230                 235                 240 


Arg Leu Ser Asp Ala Arg Ala Lys Gly His Gln Ile Leu Ala Val Val 
                245                 250                 255     


Arg Gly Ser Ala Val Asn Gln Asp Gly Ala Ser Asn Gly Leu Thr Ala 
            260                 265                 270         


Pro Asn Gly Pro Ser Gln Gln Arg Val Ile Arg Gln Ala Leu Ala Asn 
        275                 280                 285             


Ala Ser Leu Thr Val Ala Asp Val Asp Val Val Glu Ala His Gly Thr 
    290                 295                 300                 


Gly Thr Thr Leu Gly Asp Pro Ile Glu Ala Gln Ala Leu Leu Ala Thr 
305                 310                 315                 320 


Tyr Gly Gln Asp Arg Asp Arg Pro Leu Leu Leu Gly Ser Val Lys Ser 
                325                 330                 335     


Asn Leu Gly His Thr Gln Ala Ala Ala Gly Val Ala Gly Val Ile Lys 
            340                 345                 350         


Met Val Met Ala Leu Gln His Gly Ile Val Pro Gln Thr Leu His Val 
        355                 360                 365             


Ser Glu Pro Ser Arg His Val Asp Trp Thr Ala Gly Ala Val Glu Leu 
    370                 375                 380                 


Val Thr Ser Asn Gln Pro Trp Pro Ser Ser Gly Arg Pro Gly Arg Ala 
385                 390                 395                 400 


Gly Val Ser Ala Phe Gly Val Ser Gly Thr Asn Ala His Val Ile Leu 
                405                 410                 415     


Glu Gly Val Pro Ser Asn Thr Pro Val Ser Thr Ala Ala Gly Asp Val 
            420                 425                 430         


Leu Pro Leu Val Val Ser Ala Arg Thr Ala Pro Ala Val Glu Asp Leu 
        435                 440                 445             


Thr Ala Arg Leu Arg Thr Tyr Leu Ala Asp Thr Pro Gly Thr Asp Gln 
    450                 455                 460                 


Arg Ala Ala Ala Thr Thr Leu Ala Leu Thr Arg Ser Val Phe Glu His 
465                 470                 475                 480 


Arg Ala Val Leu Leu Gly Glu Asp Thr Ile Thr Gly Val Ala Val Pro 
                485                 490                 495     


Asp Ser Arg Val Val Phe Val Phe Ser Gly Gln Gly Ser Gln Arg Ala 
            500                 505                 510         


Gly Met Gly Glu Gln Leu Ala Ala Ala Phe Pro Val Phe Ala Ala Ile 
        515                 520                 525             


His Glu Arg Val Trp Ala Leu Leu Asp Val Pro Asp Gly Leu Asp Val 
    530                 535                 540                 


Asp Asp Thr Gly His Ala Gln Pro Ala Leu Phe Ala Leu Gln Val Ala 
545                 550                 555                 560 


Leu Ser Gly Leu Leu Glu Ser Trp Gly Val Arg Pro Asp Ala Val Ile 
                565                 570                 575     


Gly His Ser Ile Gly Glu Leu Ala Ala Ala Tyr Val Ser Gly Val Trp 
            580                 585                 590         


Ser Leu Glu Asp Ala Cys Ala Leu Val Ser Ala Arg Ala Arg Leu Met 
        595                 600                 605             


Gln Ala Leu Pro Ser Gly Gly Val Met Val Ala Val Pro Val Pro Glu 
    610                 615                 620                 


Ala Glu Ala Arg Ala Val Leu Arg Asp Gly Val Glu Ile Ala Ala Val 
625                 630                 635                 640 


Asn Gly Pro Ser Ser Val Val Leu Ser Gly Asp Glu Asp Ala Val Leu 
                645                 650                 655     


Gln Ala Val Ala Gly Phe Ala Lys Trp Thr Arg Leu Lys Thr Ser His 
            660                 665                 670         


Ala Phe His Ser Ala His Met Asp Pro Met Leu Asp Glu Phe Arg Ala 
        675                 680                 685             


Val Ala Glu Arg Leu Thr Tyr Arg Arg Pro Ser Val Glu Met Ala Ala 
    690                 695                 700                 


Gly Asp Arg Val Thr Thr Ala Glu Tyr Trp Val Arg Gln Val Arg Glu 
705                 710                 715                 720 


Ala Val Arg Phe Gly Asp Gln Thr Thr Ala Tyr Glu Asp Ala Val Phe 
                725                 730                 735     


Val Glu Ile Gly Pro Gly Arg Thr Leu Ala Arg Leu Ile Asp Gly Ile 
            740                 745                 750         


Thr Met Leu His Gly Glu Asn Glu Gly His Ala Ala Leu Ala Ala Leu 
        755                 760                 765             


Ser His Leu Phe Val Gln Gly Val Arg Val Asp Trp Pro Ala Val Leu 
    770                 775                 780                 


Gly Thr Thr Ala Glu Arg Val Asp Leu Pro Thr Tyr Pro Phe Gln His 
785                 790                 795                 800 


Glu His Tyr Trp Ala Arg Ala Glu His Trp Leu Ala Gly Leu Pro Ala 
                805                 810                 815     


Asp Glu Arg Glu Lys Ala Leu Leu Lys Ile Val Arg Asp Ser Ala Ala 
            820                 825                 830         


Ala Val Leu Gly His Ala Asp Gly Arg Thr Val Ala Ser Gly Ala Val 
        835                 840                 845             


Phe Lys Glu Leu Gly Leu Asp Ser Leu Thr Ala Val Glu Leu Arg Asn 
    850                 855                 860                 


Ser Leu Gly Lys Ala Thr Gly Leu Arg Leu Pro Ser Thr Ala Ala Phe 
865                 870                 875                 880 


Asp Tyr Pro Thr Pro Ala Ala Leu Ala Thr Arg Leu 
                885                 890         


<210>  59
<211>  908
<212>  PRT
<213>  Actinoplanes sp.

<400>  59

Glu Pro Leu Ala Ile Val Gly Met Ala Cys Arg Leu Pro Gly Gly Val 
1               5                   10                  15      


Ser Ser Pro Glu Asp Leu Trp Arg Leu Val Glu Ser Gly Ser Asp Ala 
            20                  25                  30          


Ile Ser Gly Phe Pro Thr Asp Arg Gly Trp Asp Val Asp Gly Leu Phe 
        35                  40                  45              


Asp Pro Asp Pro Asp Ala Ala Gly Lys Ser Tyr Cys Val Gln Gly Gly 
    50                  55                  60                  


Phe Leu Asp Ser Ala Ala Glu Phe Asp Ala Ala Phe Phe Gly Ile Ser 
65                  70                  75                  80  


Pro Arg Glu Ala Leu Ala Met Asp Pro Gln Gln Arg Leu Leu Leu Glu 
                85                  90                  95      


Thr Ser Trp Glu Ala Phe Glu Arg Ala Gly Ile Asp Pro Gly Ser Val 
            100                 105                 110         


Arg Gly Ser Asp Thr Gly Val Phe Val Gly Ala Phe Pro Gly Gly Tyr 
        115                 120                 125             


Gly Ala Gly Ala Asp Ile Glu Gly Tyr Gly Ala Thr Ala Gly Pro Ser 
    130                 135                 140                 


Val Leu Ser Gly Arg Leu Ser Tyr Phe Phe Gly Leu Glu Gly Pro Ala 
145                 150                 155                 160 


Phe Thr Val Asp Thr Ala Cys Ser Ser Ser Leu Val Ala Leu His Gln 
                165                 170                 175     


Ala Gly His Ala Leu Arg Gln Gly Glu Cys Ser Leu Ala Leu Val Gly 
            180                 185                 190         


Gly Val Thr Val Met Ala Ser Pro Val Thr Phe Val Glu Phe Ser Arg 
        195                 200                 205             


Gln Arg Gly Leu Ala Ala Asp Gly Arg Cys Lys Ala Phe Gly Asp Gly 
    210                 215                 220                 


Ala Asp Gly Thr Gly Trp Ser Glu Gly Val Gly Val Leu Leu Val Glu 
225                 230                 235                 240 


Arg Leu Ser Asp Ala Gln Ala Lys Gly His Gln Ile Leu Ala Val Val 
                245                 250                 255     


Arg Gly Ser Ala Val Asn Gln Asp Gly Ala Ser Asn Gly Leu Thr Ala 
            260                 265                 270         


Pro Asn Gly Pro Ser Gln Gln Arg Val Ile Gln Ala Ala Leu Ala Ser 
        275                 280                 285             


Ala Gly Leu Val Thr Ser Asp Val Asp Val Val Glu Ala His Gly Thr 
    290                 295                 300                 


Gly Thr Thr Leu Gly Asp Pro Ile Glu Ala Gln Ala Val Leu Ala Thr 
305                 310                 315                 320 


Tyr Gly Gln Asp Arg Ser Thr Pro Leu Leu Leu Gly Ser Leu Lys Ser 
                325                 330                 335     


Asn Ile Gly His Thr Gln Ala Ala Ala Gly Val Ser Gly Val Ile Lys 
            340                 345                 350         


Met Val Met Ala Leu Arg His Gly Val Val Pro Gln Thr Leu His Ala 
        355                 360                 365             


Asp Glu Pro Ser Arg His Val Asp Trp Ser Ala Gly Ala Val Glu Leu 
    370                 375                 380                 


Leu Thr Ser Asn Arg Ser Trp Pro Ser Ser Glu Arg Ala Arg Arg Ala 
385                 390                 395                 400 


Gly Val Ser Ala Phe Gly Val Ser Gly Thr Asn Ala His Val Ile Leu 
                405                 410                 415     


Glu Ser Ala Pro Val Glu Pro Val Val Ala Val Ala Gly Pro Val Pro 
            420                 425                 430         


Val Val Ser Asp Val Leu Pro Leu Val Leu Ser Ala Lys Ser Ala Pro 
        435                 440                 445             


Ala Leu Thr Ala Leu Glu Gln Arg Leu Arg Val Tyr Asp Gly Ala Ala 
    450                 455                 460                 


Gly Arg Ala Leu Ala Thr Ala Arg Ala Thr Phe Asp His Arg Ala Val 
465                 470                 475                 480 


Leu Ile Gly Asp Asp Thr Val Thr Gly Val Ala Val Pro Asp Pro Arg 
                485                 490                 495     


Val Val Phe Val Phe Pro Gly Gln Gly Trp Gln Trp Leu Gly Met Gly 
            500                 505                 510         


Arg Glu Leu Arg Asp Ser Ser Val Val Phe Ala Ser Arg Met Ala Glu 
        515                 520                 525             


Cys Ala Ala Ala Leu Ser Glu Phe Val Asp Trp Asp Leu Phe Thr Ala 
    530                 535                 540                 


Leu Asp Asp Pro Ala Val Val Asp Arg Val Asp Val Val Gln Pro Val 
545                 550                 555                 560 


Cys Trp Ala Val Met Val Ser Leu Ala Ala Val Trp Gln Ala Ser Gly 
                565                 570                 575     


Val Asn Pro Asp Ala Val Val Gly His Ser Gln Gly Glu Ile Ala Ala 
            580                 585                 590         


Ala Val Val Ala Gly Ser Leu Ser Leu Arg Asp Gly Ala Arg Val Val 
        595                 600                 605             


Ala Leu Arg Ser Gln Leu Ile Lys Gly Leu Ala Gly Arg Gly Ala Met 
    610                 615                 620                 


Ala Ser Ile Ala Leu Pro Ala Ala Glu Ile Asp Leu Val Glu Gly Ser 
625                 630                 635                 640 


Trp Ile Ala Ala Leu Asn Gly Pro Ser Ser Thr Val Ile Ala Gly Thr 
                645                 650                 655     


Pro Glu Ala Val Glu Gln Val Leu Ala Val Gln Asp Ala Arg Val Arg 
            660                 665                 670         


Arg Ile Ala Val Asp Tyr Ala Ser His Thr Pro Gln Val Glu Ala Ile 
        675                 680                 685             


Arg Asp Glu Leu Leu Glu Leu Thr Ala Glu Val Glu Ser Arg Arg Pro 
    690                 695                 700                 


Asp Val Pro Trp Leu Ser Thr Val Asp Asn Thr Trp Val Glu Gly Pro 
705                 710                 715                 720 


Leu Ser Ala Asp Tyr Trp Phe Arg Asn Leu Arg Glu Gln Val Gly Phe 
                725                 730                 735     


Ala Gln Ala Val Val Thr Leu Gly Asp Ala Val Phe Val Glu Val Ser 
            740                 745                 750         


Ala Ser Pro Val Leu Met Gln Ser Met Gly Asp Ala Val Thr Val Ala 
        755                 760                 765             


Thr Leu Arg Arg Asp Asp Gly Ser Ala Leu Arg Met Val Thr Ser Leu 
    770                 775                 780                 


Ala Glu Ala Tyr Val Gln Gly Val Asn Val Asn Trp Ala Ala Val Leu 
785                 790                 795                 800 


Gly Ala Gly Thr Glu Arg Ala Leu Asp Leu Pro Thr Tyr Pro Phe Gln 
                805                 810                 815     


Arg Gln His Tyr Trp Val Thr Ala Gln Ser Leu Ala Gly Leu Pro Ala 
            820                 825                 830         


Glu Asp Arg Glu Lys Ala Leu Leu Lys Ile Val Arg Asp Ser Ala Ala 
        835                 840                 845             


Gln Val Leu Gly His Pro Asp Gly Arg Ala Val Pro Ala Gly Ala Ala 
    850                 855                 860                 


Phe Ile Glu Leu Gly Val Asp Ser Leu Thr Gly Val Glu Met Arg Asn 
865                 870                 875                 880 


Arg Leu Gly Gly Ile Thr Gly Leu Arg Leu Pro Ala Thr Met Val Phe 
                885                 890                 895     


Asp Tyr Pro Thr Pro Ala Ala Leu Ala Gly Arg Leu 
            900                 905             


<210>  60
<211>  910
<212>  PRT
<213>  Actinoplanes sp.

<400>  60

Glu Pro Leu Ala Ile Val Gly Met Ala Cys Arg Leu Pro Gly Gly Val 
1               5                   10                  15      


Ser Ser Pro Glu Glu Leu Trp Arg Leu Val Glu Ser Gly Val Asp Ala 
            20                  25                  30          


Ile Ser Gly Phe Pro Val Asp Arg Gly Trp Asp Val Glu Asn Leu Phe 
        35                  40                  45              


Asp Pro Asp Pro Asp Ala Ala Gly Lys Ser Tyr Cys Val Gln Gly Gly 
    50                  55                  60                  


Phe Leu Asp Thr Ala Ala Glu Phe Asp Ala Ala Phe Phe Gly Ile Ser 
65                  70                  75                  80  


Pro Arg Glu Ala Leu Ala Met Asp Pro Gln Gln Arg Leu Val Leu Glu 
                85                  90                  95      


Thr Ser Trp Glu Ala Phe Glu Arg Ala Gly Ile Glu Pro Gly Ser Leu 
            100                 105                 110         


Lys Gly Ser Asp Thr Gly Val Tyr Met Gly Ala Phe Ser Gly Gly Tyr 
        115                 120                 125             


Ala Ala Asp Leu Glu Gly Phe Gly Ala Thr Ala Gly Ala Thr Ser Val 
    130                 135                 140                 


Leu Ser Gly Arg Val Ser Tyr Phe Phe Gly Phe Glu Gly Pro Ala Met 
145                 150                 155                 160 


Thr Val Asp Thr Ala Cys Ser Ser Ser Leu Val Ala Leu His Gln Ala 
                165                 170                 175     


Gly Tyr Ala Leu Arg Gln Gly Glu Cys Ser Leu Ala Leu Val Gly Gly 
            180                 185                 190         


Val Thr Val Met Ala Ser Pro Gln Ser Phe Val Glu Phe Ser Arg Gln 
        195                 200                 205             


Arg Gly Leu Ala Ala Asp Gly Arg Ser Lys Ala Phe Ala Asp Ala Ala 
    210                 215                 220                 


Asp Gly Thr Gly Trp Ala Glu Gly Val Gly Val Leu Leu Val Glu Arg 
225                 230                 235                 240 


Leu Ser Asp Ala Gln Ala Lys Gly His Gln Ile Leu Ala Val Val Arg 
                245                 250                 255     


Gly Ser Ala Val Asn Gln Asp Gly Ala Ser Asn Gly Leu Ser Ala Pro 
            260                 265                 270         


Asn Gly Pro Ser Gln Gln Arg Val Ile Arg Gln Ala Leu Ala Asn Ala 
        275                 280                 285             


Ser Leu Thr Pro Ala Asp Ile Asp Val Val Glu Ala His Gly Thr Gly 
    290                 295                 300                 


Thr Thr Leu Gly Asp Pro Ile Glu Ala Gln Ala Val Ile Ala Thr Tyr 
305                 310                 315                 320 


Gly Gln Asp Arg Ser Thr Pro Leu Leu Leu Gly Ser Leu Lys Ser Asn 
                325                 330                 335     


Ile Gly His Thr Gln Ala Ala Ala Gly Val Ser Gly Val Ile Lys Met 
            340                 345                 350         


Val Met Ala Leu Arg His Gly Val Val Pro Gln Thr Leu His Val Asp 
        355                 360                 365             


Gln Pro Ser Arg His Val Asp Trp Ser Ala Gly Ala Val Glu Leu Val 
    370                 375                 380                 


Thr Ser Asn Gln Pro Trp Pro Ser Ser Glu Arg Pro Arg Arg Ala Gly 
385                 390                 395                 400 


Val Ser Ala Phe Gly Val Ser Gly Thr Asn Ala His Val Ile Leu Glu 
                405                 410                 415     


Ser Ala Pro Ala Glu Pro Val Val Ala Glu Val Gly Leu Val Pro Val 
            420                 425                 430         


Val Ser Asp Val Leu Pro Leu Val Leu Ser Ala Lys Ser Ala Pro Ala 
        435                 440                 445             


Leu Thr Val Leu Glu Gln Arg Leu Arg Ala Tyr Glu Ala Ala Asp Glu 
    450                 455                 460                 


Arg Thr Val Ala Ala Thr Leu Ala Thr Ala Arg Ala Thr Phe Asp His 
465                 470                 475                 480 


Arg Ala Val Leu Ile Gly Thr Glu Thr Val Thr Gly Pro Leu Met Thr 
                485                 490                 495     


Asp Pro Arg Val Val Phe Val Phe Pro Gly Gln Gly Trp Gln Trp Leu 
            500                 505                 510         


Gly Met Gly Arg Glu Leu Arg Gly Ser Ser Val Val Phe Ala Glu Arg 
        515                 520                 525             


Met Ala Glu Cys Ala Ala Ala Leu Ser Asp Phe Val Asp Trp Asp Leu 
    530                 535                 540                 


Phe Thr Ala Leu Asp Asp Pro Ala Val Val Asp Arg Val Asp Val Val 
545                 550                 555                 560 


Gln Pro Val Cys Trp Ala Val Met Val Ser Leu Ala Ala Val Trp Gln 
                565                 570                 575     


Ala Ala Gly Val Asn Pro Asp Ala Val Val Gly His Ser Gln Gly Glu 
            580                 585                 590         


Ile Ala Ala Ala Val Val Ala Gly Ser Leu Ser Leu Arg Asp Gly Ala 
        595                 600                 605             


Leu Val Val Ala Leu Arg Ser Gln Leu Ile Lys Gly Leu Ala Gly Arg 
    610                 615                 620                 


Gly Ala Met Ala Ser Ile Ala Leu Pro Ala Asp Gln Ile Gly Leu Val 
625                 630                 635                 640 


Glu Gly Ala Trp Ile Ala Ala Leu Asn Gly Pro Ser Ser Thr Val Ile 
                645                 650                 655     


Ala Gly Ser Pro Glu Ala Val Glu Gln Val Leu Ala Ala Gln Asp Ala 
            660                 665                 670         


Arg Val Arg Arg Ile Ala Val Asp Tyr Ala Ser His Thr Pro Gln Val 
        675                 680                 685             


Glu Ala Ile Arg Asp Glu Leu Leu Glu Leu Thr Ala Gly Val Ser Ser 
    690                 695                 700                 


Gln Pro Pro Thr Val Pro Trp Leu Ser Thr Val Asp Asn Thr Trp Val 
705                 710                 715                 720 


Glu Gly Pro Leu Pro Ala Asp Tyr Trp Phe Arg Asn Leu Arg Glu Gln 
                725                 730                 735     


Val Gly Phe Ala Gln Ala Val Val Thr Leu Gly Asp Ala Val Phe Val 
            740                 745                 750         


Glu Val Ser Ala Ser Pro Val Leu Met Gln Ser Met Gly Asp Ala Val 
        755                 760                 765             


Cys Val Pro Ser Leu Arg Arg Asp Asp Gly Ser Ala Thr Arg Met Val 
    770                 775                 780                 


Thr Ser Leu Ala Glu Ala Tyr Val Gln Gly Val Asn Val Asn Trp Ala 
785                 790                 795                 800 


Ala Val Leu Gly Ala Gly Thr Glu Arg Ala Leu Asp Leu Pro Thr Tyr 
                805                 810                 815     


Pro Phe Gln Arg Gln Arg Tyr Trp Ala Gly His Trp Leu Ala Arg Leu 
            820                 825                 830         


Ala Pro Gly Glu Arg Glu Thr Ala Leu Leu Lys Leu Val Ser Glu Ser 
        835                 840                 845             


Ala Ala Ala Val Leu Gly His Ala Asp Ala Arg Ser Ile Pro Ala Thr 
    850                 855                 860                 


Ala Val Phe Arg Asp Leu Gly Met Asp Ser Leu Thr Ala Val Glu Val 
865                 870                 875                 880 


Arg Asn Ser Leu Ala Lys Thr Thr Gly Leu Arg Leu Pro Ala Thr Leu 
                885                 890                 895     


Ala Phe Asp Tyr Pro Thr Pro Ala Val Leu Ala Ala Arg Leu 
            900                 905                 910 


<210>  61
<211>  878
<212>  PRT
<213>  Actinoplanes sp.

<400>  61

Glu Pro Leu Ala Ile Val Gly Met Ala Cys Arg Leu Pro Gly Gly Val 
1               5                   10                  15      


Ser Ser Pro Glu Gly Leu Trp Arg Leu Val Val Ser Gly Ser Asp Val 
            20                  25                  30          


Ile Ser Gly Phe Pro Ala Asp Arg Gly Trp Gly Val Glu Gly Leu Arg 
        35                  40                  45              


Gly Gly Phe Leu Pro Gly Ala Ala Asp Phe Asp Ala Gly Phe Phe Gly 
    50                  55                  60                  


Ile Ser Pro Arg Glu Ala Leu Ala Met Asp Pro Gln Gln Arg Leu Val 
65                  70                  75                  80  


Leu Glu Ala Ser Trp Glu Val Leu Glu Arg Ala Gly Ile Ala Pro Gly 
                85                  90                  95      


Ser Leu Arg Gly Ser Asp Thr Gly Val Phe Met Gly Ala Tyr Pro Gly 
            100                 105                 110         


Gly Tyr Gly Ile Gly Ala Asp Leu Gly Gly Phe Gly Ala Thr Ala Gly 
        115                 120                 125             


Ala Val Ser Val Leu Ser Gly Arg Val Ser Tyr Phe Phe Gly Phe Glu 
    130                 135                 140                 


Gly Pro Ala Met Thr Val Asp Thr Ala Cys Ser Ser Ser Leu Val Ala 
145                 150                 155                 160 


Leu His Gln Ala Gly His Ala Leu Arg Asn Ser Glu Cys Ser Leu Ala 
                165                 170                 175     


Leu Val Gly Gly Val Thr Val Met Ala Ser Pro Gln Thr Phe Val Glu 
            180                 185                 190         


Phe Glu Arg Gln Gly Gly Leu Ala Ala Asp Gly Arg Ser Lys Ala Phe 
        195                 200                 205             


Ser Asp Gly Ala Asp Gly Ala Gly Phe Ser Glu Gly Val Gly Val Leu 
    210                 215                 220                 


Leu Val Glu Arg Leu Ser Asp Ala Arg Ala Lys Gly His Gln Ile Leu 
225                 230                 235                 240 


Ala Leu Val Arg Gly Ser Ala Val Asn Gln Asp Gly Ala Ser Asn Gly 
                245                 250                 255     


Leu Thr Ala Pro Asn Gly Pro Ser Gln Gln Arg Val Ile Arg Gln Ala 
            260                 265                 270         


Leu Ala Asn Ala Ser Leu Thr Val Ala Asp Val Asp Val Val Glu Ala 
        275                 280                 285             


His Gly Thr Gly Thr Thr Leu Gly Asp Pro Ile Glu Ala Gln Ala Leu 
    290                 295                 300                 


Leu Ala Thr Tyr Gly Gln Gly Arg Ser Val Pro Leu Leu Leu Gly Ser 
305                 310                 315                 320 


Val Lys Ser Asn Leu Gly His Thr Gln Ala Ala Ala Gly Val Thr Gly 
                325                 330                 335     


Val Ile Lys Met Val Met Ala Leu Arg His Gly Val Val Pro Arg Thr 
            340                 345                 350         


Leu His Val Asp Glu Pro Ser Arg His Val Asp Trp Ser Ala Gly Ala 
        355                 360                 365             


Val Glu Leu Val Thr Ser Asn Arg Glu Trp Pro Val Val Asp Arg Pro 
    370                 375                 380                 


Gly Arg Ala Gly Val Ser Ser Phe Gly Ile Ser Gly Thr Asn Ala His 
385                 390                 395                 400 


Val Ile Leu Glu Gly Ile Pro Ser Asn Thr Pro Val Ser Thr Ala Ala 
                405                 410                 415     


Gly Ala Val Leu Pro Leu Val Val Ser Ala Arg Thr Ala Pro Ala Ala 
            420                 425                 430         


Glu Asp Leu Thr Ala Arg Leu Arg Ala Tyr Leu Ser Ala Ala Pro Glu 
        435                 440                 445             


Thr Asp Gln Arg Ala Ala Ala Ala Thr Leu Ala Leu Thr Arg Ser Val 
    450                 455                 460                 


Phe Glu His Arg Thr Val Leu Leu Gly Asp Asp Thr Ile Thr Gly Ala 
465                 470                 475                 480 


Ala Met Pro Asp Pro Arg Val Val Phe Val Phe Ser Gly Gln Gly Ser 
                485                 490                 495     


Gln Arg Ala Gly Met Gly Glu Gln Leu Ala Ala Val Phe Pro Val Phe 
            500                 505                 510         


Ala Glu Ile His Glu Arg Val Trp Ala Leu Leu Asp Val Pro Asp Gly 
        515                 520                 525             


Leu Asp Ile Asp Asp Thr Gly His Ala Gln Pro Ala Leu Phe Ala Leu 
    530                 535                 540                 


Gln Val Ala Leu Ser Gly Leu Leu Glu Ser Trp Gly Val Arg Pro Asp 
545                 550                 555                 560 


Ala Val Ile Gly His Ser Ile Gly Glu Leu Ala Ala Ala Tyr Val Ser 
                565                 570                 575     


Gly Val Trp Ser Leu Glu Asp Ala Cys Ala Leu Val Ser Ala Arg Ala 
            580                 585                 590         


Arg Leu Met Gln Ala Leu Pro Pro Gly Gly Val Met Val Ala Val Pro 
        595                 600                 605             


Val Ser Glu Ala Glu Ala Arg Thr Val Leu Arg Asp Gly Val Glu Ile 
    610                 615                 620                 


Ala Ala Val Asn Gly Pro Ser Ser Val Val Leu Ser Gly Asp Glu Asp 
625                 630                 635                 640 


Ala Val Leu Gln Ala Val Ser Gly Phe Ala Lys Trp Thr Arg Leu Lys 
                645                 650                 655     


Thr Ser His Ala Phe His Ser Ala His Met Asp Pro Met Leu Asp Glu 
            660                 665                 670         


Phe Arg Ala Val Ala Glu Arg Leu Thr Tyr Arg Arg Pro Ser Val Glu 
        675                 680                 685             


Met Ala Ala Gly His Gly Val Thr Thr Ala Glu Tyr Trp Val Arg Gln 
    690                 695                 700                 


Val Arg Glu Ala Val Arg Phe Gly Asp Gln Thr Thr Ala Tyr Glu Asp 
705                 710                 715                 720 


Ala Val Phe Val Glu Ile Gly Pro Gly Arg Asn Leu Ala Arg Leu Ile 
                725                 730                 735     


Asp Gly Ile Thr Met Leu His Gly Asp Thr Glu Arg Glu Ala Ala Leu 
            740                 745                 750         


Thr Gly Leu Ser Gln Leu Phe Val Arg Gly Val Asp Val Asp Trp Ala 
        755                 760                 765             


Thr Val Ile Glu Asp Thr Thr Ala Arg Ile Leu Asp Leu Pro Thr Tyr 
    770                 775                 780                 


Pro Phe Gln His Glu Arg Tyr Trp Leu Ser Trp Leu Val Gly Leu Pro 
785                 790                 795                 800 


Pro Ala Glu Arg Ala Lys Ala Leu Leu Lys Thr Val Arg Asp Ser Ala 
                805                 810                 815     


Ala Val Val Leu Gly His Gln Gly Thr Arg Ala Ile Pro Val Asp Gly 
            820                 825                 830         


Ala Phe Arg Glu Leu Gly Met Asp Ser Leu Thr Ala Val Glu Leu Arg 
        835                 840                 845             


Asn Ser Leu Ala Lys Ala Thr Gly Leu Ser Leu Ser Ala Thr Leu Val 
    850                 855                 860                 


Phe Asp Tyr Pro Thr Pro Lys Val Leu Ala Asp His Leu Asp 
865                 870                 875             


<210>  62
<211>  907
<212>  PRT
<213>  Actinoplanes sp.

<400>  62

Glu Pro Leu Ala Ile Val Gly Met Ala Cys Arg Leu Pro Gly Gly Val 
1               5                   10                  15      


Ser Ser Pro Glu Glu Leu Trp Arg Leu Val Glu Ser Gly Ser Asp Ala 
            20                  25                  30          


Ile Ser Gly Phe Pro Val Asp Arg Gly Trp Asp Ala Asp Gly Leu Phe 
        35                  40                  45              


Asp Pro Asp Pro Asp Ala Ala Gly Lys Ser Tyr Cys Val Gln Gly Gly 
    50                  55                  60                  


Phe Leu Asp Thr Ala Ala Glu Phe Asp Ala Ala Phe Phe Gly Ile Ser 
65                  70                  75                  80  


Pro Arg Glu Ala Leu Ala Met Asp Pro Gln Gln Arg Leu Val Leu Glu 
                85                  90                  95      


Thr Ser Trp Glu Ala Phe Glu Arg Ala Gly Ile Glu Pro Gly Ser Ile 
            100                 105                 110         


Lys Gly Ser Asp Thr Gly Val Phe Ile Gly Ala Tyr Pro Gly Gly Tyr 
        115                 120                 125             


Gly Ser Gly Val Glu Leu Gly Gly Phe Gly Ala Thr Ser Gly Ala Gly 
    130                 135                 140                 


Ser Val Leu Ser Gly Arg Val Ser Tyr Phe Phe Gly Phe Glu Gly Pro 
145                 150                 155                 160 


Ala Met Thr Val Asp Thr Ala Cys Ser Ser Ser Leu Val Ala Leu His 
                165                 170                 175     


Gln Ala Gly Tyr Ala Leu Arg Gln Gly Asp Cys Ser Met Ala Leu Val 
            180                 185                 190         


Gly Gly Val Thr Val Met Ser Thr Pro His Ile Phe Val Glu Phe Ser 
        195                 200                 205             


Arg Gln Arg Gly Leu Ala Ala Asp Gly Arg Cys Lys Ala Phe Gly Asp 
    210                 215                 220                 


Gly Ala Asp Gly Thr Gly Trp Ser Glu Gly Val Gly Val Leu Leu Val 
225                 230                 235                 240 


Glu Arg Leu Ser Asp Ala Arg Ala Lys Gly His Gln Val Leu Ala Val 
                245                 250                 255     


Val Arg Gly Ser Ala Val Asn Gln Asp Gly Ala Ser Asn Gly Leu Thr 
            260                 265                 270         


Ala Pro Asn Gly Pro Ser Gln Gln Arg Val Ile His Ala Ala Leu Ala 
        275                 280                 285             


Ser Ala Gly Leu Val Thr Ser Asp Val Asp Val Val Glu Ala His Gly 
    290                 295                 300                 


Thr Gly Thr Thr Leu Gly Asp Pro Ile Glu Ala Gln Ala Val Ile Ala 
305                 310                 315                 320 


Thr Tyr Gly Gln Asp Arg Ser Thr Pro Leu Leu Leu Gly Ser Leu Lys 
                325                 330                 335     


Ser Asn Ile Gly His Thr Gln Ala Ala Ala Gly Val Ser Gly Val Ile 
            340                 345                 350         


Lys Met Val Met Ala Leu Arg His Gly Val Val Pro Gln Thr Leu His 
        355                 360                 365             


Val Asp Gln Pro Ser Arg His Val Asp Trp Ser Ala Gly Ala Val Glu 
    370                 375                 380                 


Leu Leu Thr Ser Asn Gln Pro Trp Pro Ser Ser Glu Arg Ala Arg Arg 
385                 390                 395                 400 


Ala Gly Val Ser Ala Phe Gly Val Ser Gly Thr Asn Ala His Val Ile 
                405                 410                 415     


Leu Glu Ser Ala Pro Val Glu Pro Val Val Ala Glu Ala Gly Pro Val 
            420                 425                 430         


Pro Val Val Ser Asp Val Leu Pro Leu Val Leu Ser Ala Lys Ser Ala 
        435                 440                 445             


Pro Ala Leu Arg Ala Leu Glu Gln Arg Leu Arg Val Tyr Asp Gly Ala 
    450                 455                 460                 


Ala Gly Arg Ala Leu Ala Thr Ala Arg Ala Thr Phe Asp His Arg Ala 
465                 470                 475                 480 


Val Leu Ile Gly Asp Asp Thr Val Thr Gly Val Ala Val Pro Asp Pro 
                485                 490                 495     


Arg Val Val Phe Val Phe Pro Gly Gln Gly Trp Gln Trp Leu Gly Met 
            500                 505                 510         


Gly Arg Glu Leu Arg Gly Ser Ser Val Val Phe Ala Glu Arg Met Ala 
        515                 520                 525             


Glu Cys Ala Ala Ala Leu Ser Glu Phe Val Asp Trp Asp Leu Phe Ala 
    530                 535                 540                 


Ala Leu Asp Asp Pro Ala Val Val Asp Arg Val Asp Val Val Gln Pro 
545                 550                 555                 560 


Val Cys Trp Ala Val Met Val Ser Leu Ala Ala Val Trp Gln Ala Ala 
                565                 570                 575     


Gly Val Asn Pro Asp Ala Val Val Gly His Ser Gln Gly Glu Ile Ala 
            580                 585                 590         


Ala Ala Val Val Ala Gly Ser Leu Ser Leu Arg Asp Gly Ala Leu Val 
        595                 600                 605             


Val Ala Leu Arg Ser Gln Leu Ile Lys Gly Leu Ala Gly Arg Gly Ala 
    610                 615                 620                 


Met Ala Ser Ile Ala Leu Pro Ala Thr Glu Ile Ser Leu Val Glu Gly 
625                 630                 635                 640 


Ala Trp Ile Ala Ala Leu Asn Gly Pro Ser Ser Thr Val Ile Ala Gly 
                645                 650                 655     


Ser Pro Glu Ala Val Glu Gln Val Leu Ala Val Gln Asp Ala Arg Val 
            660                 665                 670         


Arg Arg Ile Ala Val Asp Tyr Ala Ser His Thr Pro Gln Val Glu Ala 
        675                 680                 685             


Ile Arg Asp Glu Leu Leu Glu Leu Thr Ala Gly Val Ser Ser Gln Leu 
    690                 695                 700                 


Pro Thr Val Pro Trp Leu Ser Thr Val Asp Asn Thr Trp Val Glu Gly 
705                 710                 715                 720 


Pro Leu Pro Ala Asp Tyr Trp Phe Arg Asn Leu Arg Glu Gln Val Gly 
                725                 730                 735     


Phe Ala Ala Ala Val Gln Glu Leu Gly Glu Ser Val Phe Val Glu Val 
            740                 745                 750         


Ser Gly Ser Pro Val Leu Ile Gln Ser Met Gly Asp Ala Val Thr Val 
        755                 760                 765             


Ala Thr Leu Arg Arg Asp Asp Gly Ser Ala Thr Arg Met Val Thr Ser 
    770                 775                 780                 


Leu Ala Glu Ala Tyr Val Gln Gly Val Gln Val Asn Trp Ala Ala Val 
785                 790                 795                 800 


Leu Gly Ala Gly Ser Glu Arg Ala Leu Asp Leu Pro Thr Tyr Pro Phe 
                805                 810                 815     


Gln Arg Asp His Phe Trp Val Leu Ser Leu Ala Ala Leu Pro Ser Ala 
            820                 825                 830         


Glu Arg Glu Lys Ala Leu Val Lys Ile Val Cys Glu Ser Ala Ala Ala 
        835                 840                 845             


Val Leu Gly His Thr Asp Thr Ser Ala Val Pro Ala Ala Ala Ala Phe 
    850                 855                 860                 


Lys Glu Leu Gly Leu Asp Ser Leu Thr Ala Val Asp Leu Arg Asn Arg 
865                 870                 875                 880 


Leu Arg Arg Ala Thr Gly Leu Gln Leu Pro Ala Thr Leu Val Phe Asp 
                885                 890                 895     


Tyr Pro Thr Pro Thr Ala Met Ala Ala Arg Leu 
            900                 905         


<210>  63
<211>  911
<212>  PRT
<213>  Actinoplanes sp.

<400>  63

Glu Pro Leu Ala Ile Val Gly Met Ser Cys Arg Leu Pro Gly Gly Val 
1               5                   10                  15      


Ser Ser Pro Glu Asp Leu Trp Arg Leu Val Glu Ser Gly Ser Asp Ala 
            20                  25                  30          


Ile Ser Gly Phe Pro Thr Asp Arg Gly Trp Asp Val Asp Gly Leu Phe 
        35                  40                  45              


Asp Pro Asp Pro Asp Ala Ala Gly Lys Thr Tyr Cys Val Gln Gly Gly 
    50                  55                  60                  


Phe Leu Glu Ala Ala Gly Glu Phe Asp Ala Ala Phe Phe Gly Ile Ser 
65                  70                  75                  80  


Pro Arg Glu Ala Leu Thr Met Asp Pro Gln Gln Arg Val Leu Leu Glu 
                85                  90                  95      


Ala Ser Trp Glu Ala Phe Glu Arg Ala Gly Ile Ala Pro Thr Ser Val 
            100                 105                 110         


Arg Gly Thr Asp Thr Gly Val Phe Ile Gly Ala Phe Pro Val Gly Tyr 
        115                 120                 125             


Gly Ala Gly Ala Asp His Glu Gly Tyr Thr Ala Thr Ala Gly Val Gly 
    130                 135                 140                 


Ser Val Leu Ser Gly Arg Leu Ser Tyr Phe Phe Gly Leu Glu Gly Pro 
145                 150                 155                 160 


Ala Met Thr Met Asp Thr Ala Cys Ser Ser Ser Leu Val Ala Leu His 
                165                 170                 175     


Leu Ala Ala Ser Ala Leu Arg Asn Gly Glu Cys Ser Leu Ala Leu Ala 
            180                 185                 190         


Gly Gly Val Thr Val Met Ala Thr Pro Glu Val Phe Thr Glu Phe Ala 
        195                 200                 205             


Arg Gln Arg Gly Leu Ala Ala Asp Gly Arg Cys Lys Pro Phe Ala Asp 
    210                 215                 220                 


Ala Ala Asp Gly Ala Gly Phe Ser Glu Gly Ala Gly Leu Leu Val Leu 
225                 230                 235                 240 


Glu Arg Leu Ser Asp Ala Arg Arg Asn Gly His Gln Val Leu Ala Val 
                245                 250                 255     


Ile Arg Gly Ser Ala Val Asn Gln Asp Gly Ala Ser Asn Gly Leu Thr 
            260                 265                 270         


Ala Pro Asn Gly Pro Ala Gln Gln Arg Val Ile Arg Gln Ala Leu Ala 
        275                 280                 285             


Asn Ala Gly Leu Asn Ser Ser Asp Val Asp Val Leu Glu Ala His Gly 
    290                 295                 300                 


Thr Gly Thr Thr Leu Gly Asp Pro Ile Glu Ala Gln Ala Val Leu Ala 
305                 310                 315                 320 


Thr Tyr Gly Gln Asp Arg Ser Thr Pro Leu Leu Leu Gly Ser Leu Lys 
                325                 330                 335     


Ser Asn Ile Gly His Thr Gln Ala Ala Ser Gly Val Ala Gly Val Ile 
            340                 345                 350         


Lys Met Val Met Ala Leu Arg Asn Gly Leu Val Pro Arg Ser Leu His 
        355                 360                 365             


Leu Asp Glu Pro Ser Arg His Val Asp Trp Ser Ala Gly Ala Val Glu 
    370                 375                 380                 


Leu Leu Thr Ser Asn Gln Pro Trp Pro Ser Ser Asp Arg Pro Arg Arg 
385                 390                 395                 400 


Ala Gly Val Ser Ala Phe Gly Val Ser Gly Thr Asn Val His Val Ile 
                405                 410                 415     


Leu Glu Ser Ala Pro Ala Glu Pro Val Gly Ala Glu Ala Gly Pro Leu 
            420                 425                 430         


Pro Val Val Gly Asp Val Leu Pro Leu Val Val Ser Ala Lys Ser Ala 
        435                 440                 445             


Pro Ala Leu Thr Ala Leu Glu Gln Arg Leu Arg Ala His Val Ala Ala 
    450                 455                 460                 


Asp Glu Arg Ala Ala Ala Ala Thr Leu Ala Thr Ala Arg Ala Thr Phe 
465                 470                 475                 480 


Asp His Arg Ala Val Leu Ile Gly Ala Glu Thr Val Thr Gly Val Ala 
                485                 490                 495     


Ala Val Asp Pro Arg Val Val Phe Val Phe Pro Gly Gln Gly Trp Gln 
            500                 505                 510         


Trp Leu Gly Met Gly Arg Glu Leu Arg Gly Ser Ser Val Val Phe Ala 
        515                 520                 525             


Glu Arg Met Ala Glu Cys Ala Ala Ala Leu Ser Glu Phe Val Asp Trp 
    530                 535                 540                 


Asp Leu Phe Thr Ala Leu Asp Asp Pro Ala Val Val Asp Arg Val Asp 
545                 550                 555                 560 


Val Val Gln Pro Val Cys Trp Ala Val Met Val Ser Leu Ala Ala Val 
                565                 570                 575     


Trp Gln Ala Val Gly Val Asn Pro Asp Ala Val Val Gly His Ser Gln 
            580                 585                 590         


Gly Glu Ile Ala Ala Ala Val Val Ala Gly Ser Leu Ser Leu Arg Asp 
        595                 600                 605             


Gly Ala Leu Val Val Ala Leu Arg Ser Gln Leu Ile Ala Gly Leu Ala 
    610                 615                 620                 


Gly Arg Gly Ala Met Ala Ser Ile Ala Leu Pro Ala Asp Gln Ile Ser 
625                 630                 635                 640 


Leu Val Glu Gly Ala Trp Ile Ala Ala Leu Asn Gly Pro Ser Ser Thr 
                645                 650                 655     


Val Ile Ala Gly Thr Pro Glu Ala Val Glu Gln Val Leu Ala Ala Gln 
            660                 665                 670         


Asp Ala Arg Val Arg Arg Ile Ala Val Asp Tyr Ala Ser His Thr Pro 
        675                 680                 685             


Gln Val Glu Ala Ile Arg Asp Glu Leu Leu Glu Leu Thr Gly Glu Val 
    690                 695                 700                 


Val Ser Arg Lys Pro Asp Val Pro Trp Leu Ser Thr Val Asp Asn Ala 
705                 710                 715                 720 


Trp Ile Glu Gly Pro Leu Gly Ala Asp Tyr Trp Phe Arg Asn Leu Arg 
                725                 730                 735     


Glu Gln Val Gly Phe Ala Gln Ala Val Val Thr Leu Gly Asp Ala Val 
            740                 745                 750         


Phe Val Glu Val Ser Ala Ser Pro Val Leu Met Gln Ser Met Gly Asp 
        755                 760                 765             


Ala Val Cys Val Pro Ser Leu Arg Arg Asp Asp Gly Thr Ala Thr Arg 
    770                 775                 780                 


Met Val Thr Ser Leu Ala Glu Ala Tyr Val Gln Gly Val Gln Val Asn 
785                 790                 795                 800 


Trp Ala Ala Val Leu Gly Ala Gly Thr Glu Arg Ala Leu Asp Leu Pro 
                805                 810                 815     


Thr Tyr Pro Phe Gln Arg Glu Arg Phe Trp Val Leu Trp Leu Ala Gly 
            820                 825                 830         


Leu Ala Pro Gln Glu Arg Glu Thr Ala Leu Leu Lys Leu Val Cys Asp 
        835                 840                 845             


Ser Ala Ala Val Val Leu Gly His Gly Asp Gly Gln Ala Ile Pro Asp 
    850                 855                 860                 


Thr Thr Ala Phe Lys Asp Leu Gly Val Asp Ser Leu Thr Ala Val Glu 
865                 870                 875                 880 


Val Arg Asn Arg Leu Ala Ala Ala Thr Gly Leu Arg Leu Pro Ala Thr 
                885                 890                 895     


Met Val Phe Asp Tyr Pro Thr Pro Thr Ala Leu Ala Ala Arg Leu 
            900                 905                 910     


<210>  64
<211>  877
<212>  PRT
<213>  Actinoplanes sp.

<400>  64

Glu Pro Leu Ala Ile Val Gly Met Ala Cys Arg Leu Pro Gly Gly Val 
1               5                   10                  15      


Ala Ser Pro Glu Asp Leu Trp Arg Leu Val Glu Ser Gly Thr Asp Ala 
            20                  25                  30          


Ile Thr Gly Phe Pro Ala Asp Arg Gly Trp Thr Thr Glu Pro Gly Gln 
        35                  40                  45              


Gly Gly Phe Leu Ala Asp Ala Ala Gly Phe Asp Ala Ala Phe Phe Gly 
    50                  55                  60                  


Ile Ser Pro Arg Glu Ala Leu Ala Met Asp Pro Gln Gln Arg Leu Leu 
65                  70                  75                  80  


Leu Glu Thr Ser Trp Glu Ala Phe Glu Arg Ala Gly Ile Ala Pro Leu 
                85                  90                  95      


Ser Leu Arg Gly Ser Asp Thr Gly Val Tyr Ile Gly Ala Tyr Pro Asp 
            100                 105                 110         


Gly Tyr Gly Ile Gly Ala Asp Leu Gly Gly Phe Gly Thr Thr Ala Gly 
        115                 120                 125             


Ser Pro Ser Val Leu Ser Gly Arg Val Ser Tyr Phe Phe Gly Leu Glu 
    130                 135                 140                 


Gly Pro Ala Ile Thr Val Asp Thr Ala Cys Ser Ser Ser Leu Val Ala 
145                 150                 155                 160 


Leu His Gln Ala Gly Tyr Ala Leu Arg Asn Asn Glu Cys Ser Leu Ala 
                165                 170                 175     


Leu Val Gly Gly Val Thr Val Met Ala Thr Pro Glu Val Phe Ser Ala 
            180                 185                 190         


Phe Ala Leu Gln Asp Gly Leu Ala Ala Asp Gly Arg Ser Lys Ala Phe 
        195                 200                 205             


Ser Asp Gly Ala Asp Gly Ala Gly Phe Ser Glu Gly Val Gly Val Leu 
    210                 215                 220                 


Leu Val Glu Arg Leu Ser Asp Ala Gln Ala Asn Gly His Gln Ile Leu 
225                 230                 235                 240 


Ala Leu Val Arg Gly Ser Ala Val Asn Gln Asp Gly Ala Ser Asn Gly 
                245                 250                 255     


Leu Thr Ala Pro Asn Gly Pro Ser Gln Gln Arg Val Ile Arg Gln Ala 
            260                 265                 270         


Leu Ala Asn Ala Ser Leu Thr Pro Ala Asp Val Asp Val Ile Glu Ala 
        275                 280                 285             


His Gly Thr Gly Thr Thr Leu Gly Asp Pro Ile Glu Ala Gln Ala Leu 
    290                 295                 300                 


Leu Ala Thr Tyr Gly Gln Gly Arg Ser Val Pro Leu Leu Leu Gly Ser 
305                 310                 315                 320 


Val Lys Ser Asn Leu Gly His Thr Gln Ala Ala Ala Gly Val Thr Gly 
                325                 330                 335     


Val Ile Lys Met Val Met Ala Leu Arg His Gly Val Val Pro Arg Thr 
            340                 345                 350         


Leu His Val Asp Glu Pro Ser Arg His Val Asp Trp Ser Ala Gly Ala 
        355                 360                 365             


Val Glu Leu Val Thr Ser Asn Arg Glu Trp Pro Val Thr Asp Arg Pro 
    370                 375                 380                 


Gly Arg Ala Gly Val Ser Ser Phe Gly Ile Ser Gly Thr Asn Ala His 
385                 390                 395                 400 


Val Ile Leu Glu Ala Val Pro Val Val Ser Ala Val Ser Thr Gly Gly 
                405                 410                 415     


Glu Val Gln Pro Leu Val Val Ser Ala Arg Thr Ala Pro Ala Ala Glu 
            420                 425                 430         


Asp Leu Ala Ser Arg Leu Arg Thr Tyr Leu Ala Asp Thr Pro Asp Thr 
        435                 440                 445             


Asp Gln Arg Ala Ala Ala Ala Thr Leu Ala Leu Thr Arg Ser Val Phe 
    450                 455                 460                 


Glu His Arg Thr Val Leu Leu Gly Asp Asp Thr Ile Thr Gly Ala Ala 
465                 470                 475                 480 


Met Pro Asp Pro Arg Val Val Phe Val Phe Ser Gly Gln Gly Ser Gln 
                485                 490                 495     


Arg Ala Gly Met Gly Glu Gln Leu Ala Ala Val Phe Pro Val Phe Ala 
            500                 505                 510         


Glu Ile His Glu Arg Val Trp Ala Leu Leu Asp Val Pro Asp Gly Leu 
        515                 520                 525             


Asp Ile Asp Asp Thr Gly His Ala Gln Pro Ala Leu Phe Ala Leu Gln 
    530                 535                 540                 


Val Ala Leu Ser Gly Leu Leu Glu Ser Trp Gly Val Arg Pro Asp Ala 
545                 550                 555                 560 


Val Ile Gly His Ser Ile Gly Glu Leu Ala Ala Ala Tyr Val Ser Gly 
                565                 570                 575     


Val Trp Ser Leu Glu Asp Ala Cys Ala Leu Val Ser Ala Arg Ala Arg 
            580                 585                 590         


Leu Met Gln Ala Leu Pro Pro Gly Gly Val Met Val Ala Val Pro Val 
        595                 600                 605             


Pro Glu Ala Glu Ala Arg Thr Val Leu Arg Asp Gly Val Glu Ile Ala 
    610                 615                 620                 


Ala Val Asn Gly Pro Ser Ser Val Val Leu Ser Gly Asp Glu Asp Ala 
625                 630                 635                 640 


Val Leu Gln Ala Val Ser Gly Phe Ala Lys Trp Thr Arg Leu Lys Thr 
                645                 650                 655     


Ser His Ala Phe His Ser Ala His Met Asp Pro Met Leu Asp Glu Phe 
            660                 665                 670         


Arg Thr Val Ala Glu Arg Leu Thr Tyr Arg Arg Pro Ser Val Glu Met 
        675                 680                 685             


Ala Ala Gly His Gly Val Thr Thr Ala Glu Tyr Trp Val Arg Gln Val 
    690                 695                 700                 


Arg Glu Ala Val Arg Phe Gly Asp Gln Thr Thr Ala Tyr Glu Asp Ala 
705                 710                 715                 720 


Val Phe Val Glu Ile Gly Pro Gly Arg Thr Leu Ala Arg Leu Ile Asp 
                725                 730                 735     


Gly Ile Thr Met Leu His Gly Asp Thr Glu Arg Glu Ala Ala Leu Thr 
            740                 745                 750         


Gly Leu Ser Gln Leu Phe Val Arg Gly Val Asp Val Asp Trp Ala Thr 
        755                 760                 765             


Val Ile Glu Asp Thr Thr Ala Arg Ile Leu Asp Leu Pro Thr Tyr Pro 
    770                 775                 780                 


Phe Gln His Glu Arg Tyr Trp Ala Gly Arg Trp Leu Ala Gly Leu Ala 
785                 790                 795                 800 


Pro Asp Lys Arg Asp Ala Ala Leu Leu Thr Met Val Arg Asp Ser Ala 
                805                 810                 815     


Ala Arg Val Leu Gly His Ala Asp Gly Ser Ala Ile Ser Pro Thr Ala 
            820                 825                 830         


Thr Phe Arg Asp Leu Gly Val Asp Ser Leu Thr Ala Val Glu Leu Arg 
        835                 840                 845             


Asn Arg Leu Ala Arg Thr Ala Gly Leu Arg Leu Ala Thr Thr Ile Val 
    850                 855                 860                 


Phe Asp Tyr Pro Thr Pro Thr Ala Leu Ala Ala His Leu 
865                 870                 875         


<210>  65
<211>  883
<212>  PRT
<213>  Actinoplanes sp.

<400>  65

Glu Pro Leu Ala Ile Val Gly Met Ala Cys Arg Leu Pro Gly Gly Val 
1               5                   10                  15      


Ala Ser Pro Glu Asp Leu Trp Arg Leu Val Glu Ser Gly Thr Asp Ala 
            20                  25                  30          


Ile Thr Gly Leu Pro Thr Asp Arg Gly Trp Asp Leu Gly Ala Val Ala 
        35                  40                  45              


Ala Glu Ser Tyr Cys Val Glu Gly Gly Phe Leu Asp Gly Val Ala Gly 
    50                  55                  60                  


Phe Asp Ala Ala Phe Phe Gly Ile Ser Pro Arg Glu Ala Leu Ala Met 
65                  70                  75                  80  


Asp Pro Gln Gln Arg Leu Leu Leu Glu Thr Ser Trp Glu Ser Leu Glu 
                85                  90                  95      


Arg Ala Gly Ile Ala Pro Leu Ser Leu Arg Gly Ser Asp Thr Gly Val 
            100                 105                 110         


Phe Met Gly Ala Tyr Pro Gly Gly Tyr Gly Ala Gly Ala Asp Leu Gly 
        115                 120                 125             


Gly Phe Gly Thr Thr Ser Gly Ala Ala Ser Val Leu Ser Gly Arg Ile 
    130                 135                 140                 


Ser Tyr Phe Phe Gly Leu Glu Gly Pro Ala Met Thr Val Asp Thr Ala 
145                 150                 155                 160 


Cys Ser Ser Ser Leu Val Ala Leu His Leu Ala Gly Gln Ala Leu Arg 
                165                 170                 175     


Asn Gly Glu Cys Ser Leu Ala Leu Val Gly Gly Val Thr Val Met Ala 
            180                 185                 190         


Ala Pro Asp Ile Phe Pro Glu Phe Ala Arg Gln Arg Gly Leu Ala Ser 
        195                 200                 205             


Asp Gly Arg Ser Lys Ala Phe Ala Asp Ser Ala Asp Gly Thr Gly Trp 
    210                 215                 220                 


Ser Glu Gly Val Gly Val Leu Leu Val Glu Arg Leu Ser Asp Ala Gln 
225                 230                 235                 240 


Ala Asn Gly His Gln Ile Leu Ala Leu Val Arg Gly Ser Ala Val Asn 
                245                 250                 255     


Gln Asp Gly Ala Ser Asn Gly Leu Thr Ala Pro Asn Gly Pro Ser Gln 
            260                 265                 270         


Gln Arg Val Ile Arg Gln Ala Leu Ala Asn Ala Ser Leu Thr Pro Ala 
        275                 280                 285             


Asp Val Asp Val Ile Glu Ala His Gly Thr Gly Thr Thr Leu Gly Asp 
    290                 295                 300                 


Pro Ile Glu Ala Gln Ala Leu Leu Ala Thr Tyr Gly Gln Gly Arg Ser 
305                 310                 315                 320 


Val Pro Leu Leu Leu Gly Ser Val Lys Ser Asn Leu Gly His Thr Gln 
                325                 330                 335     


Ala Ala Ala Gly Val Thr Gly Val Ile Lys Met Val Met Ala Leu Arg 
            340                 345                 350         


His Gly Val Val Pro Gln Thr Leu His Val Asp Glu Pro Ser Arg His 
        355                 360                 365             


Val Asp Trp Ser Ala Gly Ala Val Glu Leu Val Thr Ser Asn Arg Glu 
    370                 375                 380                 


Trp Pro Val Thr Asp Arg Pro Gly Arg Ala Gly Val Ser Ser Phe Gly 
385                 390                 395                 400 


Ile Ser Gly Thr Asn Ala His Val Ile Leu Glu Ala Val Pro Ser Asp 
                405                 410                 415     


Thr Pro Ala Pro Thr Thr Thr Asp Ala Val Leu Pro Leu Val Val Ser 
            420                 425                 430         


Thr Arg Thr Ala Pro Ala Ala Glu Asp Leu Thr Ala Arg Leu Arg Ala 
        435                 440                 445             


Tyr Leu Ser Ala Ala Pro Glu Thr Asp Gln Arg Ala Ala Ala Ala Thr 
    450                 455                 460                 


Leu Ala Leu Thr Arg Ser Val Phe Glu His Arg Ala Val Val Leu Gly 
465                 470                 475                 480 


Glu Asp Thr Ile Thr Gly Val Ala Val Pro Asp Pro Arg Val Val Phe 
                485                 490                 495     


Val Phe Ser Gly Gln Gly Ser Gln Arg Ala Gly Met Gly Glu Gln Leu 
            500                 505                 510         


Ala Ala Ala Tyr Pro Val Phe Ala Ala Ile His Glu Arg Val Trp Ala 
        515                 520                 525             


Leu Leu Asp Val Pro Asp Gly Leu Asp Val Asp Asp Thr Gly His Ala 
    530                 535                 540                 


Gln Pro Ala Leu Phe Ala Leu Gln Val Ala Leu Ser Gly Leu Leu Glu 
545                 550                 555                 560 


Ser Trp Gly Val Arg Pro Ala Ala Val Ile Gly His Ser Ile Gly Glu 
                565                 570                 575     


Leu Ala Ala Ala Tyr Val Ser Gly Val Trp Ser Leu Glu Asp Ala Cys 
            580                 585                 590         


Val Leu Val Ser Ala Arg Ala Arg Leu Met Gln Ala Leu Pro Pro Gly 
        595                 600                 605             


Gly Val Met Val Ala Val Pro Val Pro Glu Ala Glu Ala Arg Ala Val 
    610                 615                 620                 


Leu Arg Asp Gly Val Glu Ile Ala Ala Val Asn Gly Pro Ser Ser Val 
625                 630                 635                 640 


Val Leu Ser Gly Asp Glu Asp Ala Val Leu Gln Ala Val Ser Gly Phe 
                645                 650                 655     


Ala Lys Trp Thr Arg Leu Lys Thr Ser His Ala Phe His Ser Ala His 
            660                 665                 670         


Met Asp Pro Met Leu Asp Glu Phe Arg Ala Val Ala Glu Arg Leu Thr 
        675                 680                 685             


Tyr Arg Arg Pro Ser Val Glu Met Ala Ala Gly Asp Arg Val Thr Thr 
    690                 695                 700                 


Ala Glu Tyr Trp Val Arg Gln Val Arg Glu Ala Val Arg Phe Gly Asp 
705                 710                 715                 720 


Gln Thr Thr Ala Tyr Glu Asp Ala Val Phe Val Glu Ile Gly Pro Gly 
                725                 730                 735     


Arg Thr Leu Ala Arg Leu Ile Asp Gly Ile Thr Met Leu His Gly Asp 
            740                 745                 750         


Thr Glu Arg Glu Ala Ala Leu Thr Gly Leu Ser Gln Leu Phe Val Arg 
        755                 760                 765             


Gly Val Asp Val Asp Trp Ala Thr Val Ile Glu Asp Thr Thr Ala Arg 
    770                 775                 780                 


Ile Leu Asp Leu Pro Thr Tyr Pro Phe Gln His Glu His Tyr Trp Leu 
785                 790                 795                 800 


Arg Arg Ala Ala Arg Thr Pro Ala Glu Arg Ala Gln Glu Leu Leu Lys 
                805                 810                 815     


Leu Val Arg Asp Asn Ala Ala Ala Val Leu Gly His Ala Asp Gly Arg 
            820                 825                 830         


Thr Val Pro Ala Ala Ala Ala Phe Arg Asp Leu Gly Val Asp Ser Leu 
        835                 840                 845             


Ile Ala Val Glu Leu Arg Asn Asn Leu Ala Leu Ala Thr Gly Leu Gln 
    850                 855                 860                 


Leu Pro Thr Thr Ile Val Phe Asp Tyr Pro Thr Ala Ser Ser Leu Ala 
865                 870                 875                 880 


Glu Arg Leu 
            


<210>  66
<211>  911
<212>  PRT
<213>  Actinoplanes sp.

<400>  66

Glu Pro Leu Ala Ile Val Gly Met Ala Cys Arg Leu Pro Gly Gly Val 
1               5                   10                  15      


Glu Ser Pro Glu Asp Leu Trp Arg Leu Val Glu Ser Gly Ala Asp Ala 
            20                  25                  30          


Ile Ser Gly Phe Pro Thr Asp Arg Gly Trp Asp Ala Asp Gly Leu Phe 
        35                  40                  45              


Asp Pro Asp Leu Ala Val Gly Lys Thr Tyr Cys Val Gln Gly Gly Phe 
    50                  55                  60                  


Leu Gln Thr Ala Ala Glu Phe Asp Pro Ala Phe Phe Gly Ile Ser Pro 
65                  70                  75                  80  


Arg Glu Ala Leu Ala Met Asp Pro Gln Gln Arg Leu Val Leu Glu Thr 
                85                  90                  95      


Ser Trp Glu Ala Phe Glu Arg Ala Gly Ile Glu Pro Gly Ser Leu Lys 
            100                 105                 110         


Gly Ser Asp Thr Gly Val Phe Met Gly Ala Tyr Pro Gly Gly Tyr Gly 
        115                 120                 125             


Met Gly Ala Asp Leu Gly Gly Phe Ala Ala Thr Ala Gly Ala Gly Ser 
    130                 135                 140                 


Val Leu Ser Gly Arg Val Ser Tyr Phe Phe Gly Phe Glu Gly Pro Ala 
145                 150                 155                 160 


Met Thr Val Asp Thr Ala Cys Ser Ser Ser Leu Val Ala Leu His Gln 
                165                 170                 175     


Ala Gly Tyr Ala Leu Arg Gln Gly Glu Cys Ser Leu Ala Leu Val Gly 
            180                 185                 190         


Gly Val Thr Val Met Ala Ser Pro Gln Ser Phe Val Glu Phe Ser Arg 
        195                 200                 205             


Gln Arg Gly Leu Ala Ala Asp Gly Arg Ser Lys Ala Phe Ala Asp Ala 
    210                 215                 220                 


Ala Asp Gly Thr Gly Trp Ala Glu Gly Val Gly Val Leu Leu Val Glu 
225                 230                 235                 240 


Arg Leu Ser Asp Ala Gln Ala Lys Gly His Arg Ile Leu Ala Val Val 
                245                 250                 255     


Arg Gly Ser Ala Val Asn Gln Asp Gly Ala Ser Asn Gly Leu Ser Ala 
            260                 265                 270         


Pro Asn Gly Pro Ser Gln Gln Arg Val Ile Arg Gln Ala Leu Ala Asn 
        275                 280                 285             


Ala Ser Leu Thr Pro Ala Asp Ile Asp Val Val Glu Ala His Gly Thr 
    290                 295                 300                 


Gly Thr Thr Leu Gly Asp Pro Ile Glu Ala Gln Ala Val Ile Ala Thr 
305                 310                 315                 320 


Tyr Gly Gln Asp Arg Ser Thr Pro Leu Leu Leu Gly Ser Leu Lys Ser 
                325                 330                 335     


Asn Ile Gly His Thr Gln Ala Ala Ala Gly Val Ser Gly Val Ile Lys 
            340                 345                 350         


Met Val Met Ala Leu Arg His Gly Val Val Pro Gln Thr Leu His Val 
        355                 360                 365             


Asp Gln Pro Ser Arg His Val Asp Trp Ser Ala Gly Ala Val Glu Leu 
    370                 375                 380                 


Val Thr Ser Asn Gln Pro Trp Pro Ser Ser Glu Arg Pro Arg Arg Ala 
385                 390                 395                 400 


Gly Val Ser Ala Phe Gly Val Ser Gly Thr Asn Ala His Val Ile Leu 
                405                 410                 415     


Glu Ser Ala Pro Val Glu Pro Val Gly Ala Glu Ala Gly Leu Val Pro 
            420                 425                 430         


Val Val Ala Asp Val Leu Pro Trp Val Val Ser Ala Lys Ser Ala Pro 
        435                 440                 445             


Ala Leu Arg Ala Leu Glu Gln Arg Leu Arg Ala Tyr Glu Ala Ala Asp 
    450                 455                 460                 


Glu Arg Thr Val Val Ala Thr Leu Ala Thr Ala Arg Ala Thr Phe Asp 
465                 470                 475                 480 


His Arg Ala Val Leu Ile Gly Thr Glu Thr Val Thr Gly Pro Leu Met 
                485                 490                 495     


Thr Asp Pro Arg Val Val Phe Val Phe Pro Gly Gln Gly Trp Gln Trp 
            500                 505                 510         


Leu Gly Met Gly Arg Glu Leu Arg Gly Ser Ser Val Val Phe Ala Glu 
        515                 520                 525             


Arg Met Ala Glu Cys Ala Ala Ala Leu Ser Glu Phe Val Asp Trp Asp 
    530                 535                 540                 


Leu Phe Thr Ala Leu Asp Asp Pro Ala Val Val Asp Arg Val Asp Val 
545                 550                 555                 560 


Val Gln Pro Val Cys Trp Ala Val Met Val Ser Leu Ala Ala Val Trp 
                565                 570                 575     


Gln Ala Ala Gly Val Asn Pro Asp Ala Val Val Gly His Ser Gln Gly 
            580                 585                 590         


Glu Ile Ala Ala Ala Val Val Ala Gly Ser Leu Ser Leu Arg Asp Gly 
        595                 600                 605             


Ala Leu Val Val Ala Leu Arg Ser Gln Leu Ile Lys Gly Leu Ala Gly 
    610                 615                 620                 


Arg Gly Ala Met Ala Ser Ile Ala Leu Pro Ala Asp Gln Ile Asp Leu 
625                 630                 635                 640 


Val Glu Gly Ala Trp Ile Ala Ala Leu Asn Gly Pro Ser Ser Thr Val 
                645                 650                 655     


Ile Ala Gly Thr Pro Glu Ala Val Glu Gln Val Leu Ala Ala Gln Asp 
            660                 665                 670         


Ala Arg Val Arg Arg Ile Ala Val Asp Tyr Ala Ser His Thr Pro Gln 
        675                 680                 685             


Val Glu Ala Ile Arg Asp Glu Leu Leu Glu Leu Thr Ala Glu Val Leu 
    690                 695                 700                 


Ser Arg Lys Pro Asp Val Pro Trp Leu Ser Thr Val Asp Asn Thr Trp 
705                 710                 715                 720 


Val Glu Gly Pro Leu Pro Ala Asp Tyr Trp Phe Arg Asn Leu Arg Glu 
                725                 730                 735     


Gln Val Gly Phe Ala Gln Ala Val Val Thr Leu Gly Asp Ala Val Phe 
            740                 745                 750         


Val Glu Val Ser Ala Ser Pro Val Leu Ile Gln Ser Met Gly Asp Ala 
        755                 760                 765             


Val Thr Val Ala Thr Leu Arg Arg Asp Asp Gly Ser Ala Thr Arg Met 
    770                 775                 780                 


Val Thr Ser Leu Ala Glu Ala Tyr Val Gln Gly Val Gln Val Asn Trp 
785                 790                 795                 800 


Gly Ala Val Leu Gly Ala Gly Thr Glu Arg Ala Leu Asp Leu Pro Thr 
                805                 810                 815     


Tyr Pro Phe Gln Arg Gln His Tyr Trp Ala Leu Glu Arg Leu Gly Glu 
            820                 825                 830         


Arg Ala Gly Thr Glu Arg His Arg Leu Met Leu Glu Val Val Leu Gly 
        835                 840                 845             


His Ala Ala Ser Val Leu Gly His Ser Ser Ala Ala Ala Leu Glu Pro 
    850                 855                 860                 


Asp Arg Pro Phe Lys Asp Leu Gly Met Asp Ser Leu Thr Ala Ile Glu 
865                 870                 875                 880 


Leu Arg Asn His Leu Val Ala Glu Thr Gly Leu Arg Leu Pro Ala Thr 
                885                 890                 895     


Met Val Phe Asp Phe Pro Thr Ala Asp Ala Leu Ala Gly His Leu 
            900                 905                 910     


<210>  67
<211>  934
<212>  PRT
<213>  Actinoplanes sp.

<400>  67

Glu Pro Ile Ala Val Val Ser Met Ala Cys Arg Leu Pro Gly Gly Val 
1               5                   10                  15      


Asp Thr Pro Glu Gly Leu Trp Arg Leu Val Glu Ser Gly Thr Asp Ala 
            20                  25                  30          


Ile Ser Gly Phe Pro Thr Asp Arg Gly Trp Asp Leu Thr Asp Phe Tyr 
        35                  40                  45              


Ser Ala Asp Pro Gln Gly Gly Phe Leu Thr Gly Ala Ala Glu Phe Asp 
    50                  55                  60                  


Ala Gly Phe Phe Gly Ile Ser Pro Arg Glu Ala Leu Gly Met Asp Pro 
65                  70                  75                  80  


Gln Gln Arg Leu Leu Leu Glu Thr Thr Trp Glu Ala Ile Glu Arg Ala 
                85                  90                  95      


Gln Leu Asp Pro Arg Ser Leu Arg Gly Arg Asp Val Gly Val Tyr Val 
            100                 105                 110         


Gly Gly Ala Ala Gln Gly Tyr Gly Val Gly Phe Ala Gly Glu Pro Arg 
        115                 120                 125             


Asp Asn Ala Ile Thr Ala Ser Ser Ile Ser Leu Leu Ser Gly Arg Val 
    130                 135                 140                 


Ser Tyr Ala Leu Gly Leu Gln Gly Pro Gly Val Thr Val Asp Thr Ala 
145                 150                 155                 160 


Cys Ser Ser Ser Leu Val Ala Leu His Leu Ala Cys Gln Ala Leu Arg 
                165                 170                 175     


Gln Arg Glu Cys Ser Leu Ala Leu Val Gly Gly Val Ser Val Ile Ala 
            180                 185                 190         


Thr Pro Asp Val Phe Ala Glu Phe Ser Arg Gln Asn Gly Leu Ala Ala 
        195                 200                 205             


Asp Gly Arg Cys Lys Ser Phe Gly Ala Ala Ala Asp Gly Thr Gly Trp 
    210                 215                 220                 


Ser Glu Gly Val Gly Met Leu Val Leu Glu Arg Leu Ser Glu Ala Thr 
225                 230                 235                 240 


Arg His Gly His Arg Ile Leu Ala Val Val Arg Gly Ser Ala Val Asn 
                245                 250                 255     


Ser Asp Gly Ala Ser Asn Gly Leu Thr Ala Pro Asn Gly Gln Ser Gln 
            260                 265                 270         


Gln Arg Val Ile Arg Gln Ala Leu Ser Asn Ala Gly Leu Ala Ala Ser 
        275                 280                 285             


Asp Val Asp Val Val Glu Ala His Gly Thr Gly Thr Arg Leu Gly Asp 
    290                 295                 300                 


Pro Ile Glu Ala Glu Ala Ile Leu Ala Thr Tyr Gly Gln Asp Arg Ala 
305                 310                 315                 320 


Ala Pro Ala Trp Leu Gly Ser Leu Lys Ser Asn Ile Gly His Thr Met 
                325                 330                 335     


Ala Ala Ser Gly Val Leu Gly Val Ile Lys Met Val Glu Ala Met Arg 
            340                 345                 350         


His Gly Thr Val Pro Arg Thr Leu His Val Asp Glu Pro Ser Pro His 
        355                 360                 365             


Val Asp Trp Ser Ala Gly Arg Val Ala Leu Leu Thr Glu Asn Gln Pro 
    370                 375                 380                 


Trp Pro Asp Gly Ala Lys Pro Arg Arg Ala Gly Val Ser Ser Phe Gly 
385                 390                 395                 400 


Leu Ser Gly Thr Asn Ala His Val Val Leu Glu Gln His Pro Glu Pro 
                405                 410                 415     


Ala Ser Pro Val Pro Ala Arg Glu Thr Gly Pro Val Pro Trp Val Leu 
            420                 425                 430         


Ser Ala Gln Ser Pro Lys Ala Leu Gln Glu Gln Ala Gly Arg Leu His 
        435                 440                 445             


Ala Ala Leu Val Ser Asp Pro Arg Trp His Pro Leu Asp Val Ala Phe 
    450                 455                 460                 


Ser Leu Ala Thr Thr Arg Ser Ala Phe Thr His Arg Thr Ala Val Val 
465                 470                 475                 480 


Ala Ser Gly Arg Asp Leu Leu Glu Ala Leu Ser Thr Leu Ala Thr Ser 
                485                 490                 495     


Ala Thr Ala Thr Ser Thr Thr Ala Arg Thr Arg Arg Val Ala Phe Leu 
            500                 505                 510         


Phe Asp Gly Gln Gly Thr Gln Arg Ala Gly Met Gly Arg Glu Leu Tyr 
        515                 520                 525             


Glu Arg His Pro Ala Phe Ala Arg Ala Trp Asp Glu Val Ser Ala Ala 
    530                 535                 540                 


Phe Asp Lys His Leu Glu His Pro Leu His Ala Val Tyr Phe Gly Ala 
545                 550                 555                 560 


Gly Ala Leu Asp Glu Leu Val Asp Asp Thr Gly Tyr Ala Gln Ala Ala 
                565                 570                 575     


Ile Phe Thr Phe Glu Val Ala Leu Phe Glu Leu Leu His Glu Trp Gly 
            580                 585                 590         


Val Arg Pro Asp Phe Val Ala Gly His Ser Ile Gly Glu Val Ala Ala 
        595                 600                 605             


Ala Tyr Val Ser Gly Leu Phe Ser Leu Ala Asp Ala Ala Gln Leu Ile 
    610                 615                 620                 


Val Ala Arg Gly Arg Ala Leu Arg Ser Ala Pro Pro Gly Ala Met Ala 
625                 630                 635                 640 


Ala Leu Arg Ala Gly Glu Thr Glu Thr Arg Glu Phe Leu Ala Arg Thr 
                645                 650                 655     


Gly Thr Ala Leu Asp Val Ala Ala Val Asn Ser Pro Glu Ala Val Val 
            660                 665                 670         


Val Ser Gly Ser Pro Glu Ala Val Ala Glu Phe Thr Ala Ala Trp Thr 
        675                 680                 685             


Ala Ser Gly Arg Arg Ala Arg Arg Leu Asn Val Asn Arg Ala Phe His 
    690                 695                 700                 


Ser Arg His Val Asp Gly Leu Leu Asp Asp Phe Arg Ala Val Leu Glu 
705                 710                 715                 720 


Ser Leu Thr Cys Arg Thr Asp Thr Val Leu Pro Met Val Ser Thr Val 
                725                 730                 735     


Thr Gly Arg Leu Ile Asp Pro Ala Glu Leu Arg Thr Pro Gln Tyr Trp 
            740                 745                 750         


Leu Ser Gln Val Arg Asp Thr Val Arg Phe Gln Asp Ala Val Ala Glu 
        755                 760                 765             


Leu Ala Ala Asn Gly Val Gly Val Phe Val Glu Val Gly Pro Ser Ser 
    770                 775                 780                 


Ser Leu Ala Ser Ala Gly Thr Glu Thr Leu Gly Asp Glu Ala His Phe 
785                 790                 795                 800 


Gln Ala Leu Gln His Ser Arg Thr Pro Ala Asp Pro Ala Leu Leu Thr 
                805                 810                 815     


Ala Leu Ala Gly Leu His Ser Gly Gly Val Gly Val Asp Trp Glu Lys 
            820                 825                 830         


Val Leu Val Gly Gly Arg Ala Val Glu Leu Pro Val Tyr Pro Phe Gln 
        835                 840                 845             


His Arg Ala Tyr Trp Leu Ala Pro Ala Ser Thr Gln Glu Pro Ala Thr 
    850                 855                 860                 


Met Leu Glu Leu Val Arg Phe Glu Val Ala Ala Val Leu Gly Met Pro 
865                 870                 875                 880 


Asp Pro Ala Ala Val Phe Glu Glu Thr Ser Phe Leu Glu Leu Gly Phe 
                885                 890                 895     


Asp Ser Leu Ser Ala Val Arg Leu Arg Asn Arg Leu Thr Arg Ser Thr 
            900                 905                 910         


Gly Val Glu Leu Pro Ala Thr Leu Leu Phe Asp His Pro Thr Pro Ala 
        915                 920                 925             


Glu Leu Ala Ala His Leu 
    930                 


<210>  68
<211>  928
<212>  PRT
<213>  Streptomyces hygroscopicus

<400>  68

Glu Pro Leu Ala Ile Val Gly Met Ala Cys Arg Leu Pro Gly Gly Val 
1               5                   10                  15      


Ala Ser Pro Glu Asp Leu Trp Arg Leu Val Glu Ser Gly Thr Asp Ala 
            20                  25                  30          


Ile Ser Asp Phe Pro Thr Asp Arg Gly Trp Asp Val Glu Gly Leu Tyr 
        35                  40                  45              


Asp Pro Asp Pro Asp Val Pro Gly Lys Ser Tyr Ala Val Lys Gly Gly 
    50                  55                  60                  


Phe Leu Asp Ala Ala Gly Phe Asp Ala Ala Phe Phe Gly Ile Ser Pro 
65                  70                  75                  80  


Arg Glu Ala Ala Ala Met Asp Pro Gln Gln Arg Leu Val Leu Glu Ala 
                85                  90                  95      


Ser Trp Glu Ala Phe Glu Arg Ala Gly Ile Glu Pro Gly Ser Val Arg 
            100                 105                 110         


Gly Ser Asp Thr Gly Val Phe Met Gly Ala Met Ala Asn Gly Tyr Gly 
        115                 120                 125             


Ala Gly Ala Asp Leu Gly Gly Phe Gly Ala Thr Ala Gly Ala Gly Ser 
    130                 135                 140                 


Val Leu Ser Gly Arg Ile Ser Tyr Phe Phe Gly Leu Glu Gly Pro Ala 
145                 150                 155                 160 


Met Thr Val Asp Thr Ala Cys Ser Ser Ser Leu Val Ala Leu His Gln 
                165                 170                 175     


Ala Ser Phe Ala Leu Arg Gln Gly Glu Cys Ser Leu Ala Leu Val Gly 
            180                 185                 190         


Gly Val Thr Val Met Pro Thr Pro Gln Leu Phe Val Glu Phe Ala Arg 
        195                 200                 205             


Gln Arg Gly Leu Ala Val Asp Gly Arg Ser Lys Ala Phe Ala Asp Ala 
    210                 215                 220                 


Ala Asp Gly Ser Gly Phe Ser Glu Gly Val Gly Val Leu Val Val Glu 
225                 230                 235                 240 


Arg Leu Ser Asp Ala Gln Ala Lys Gly His Arg Val Leu Ala Val Val 
                245                 250                 255     


Arg Gly Ser Ala Val Asn Gln Asp Gly Ala Ser Asn Gly Leu Ser Ala 
            260                 265                 270         


Pro Asn Gly Pro Ser Gln Gln Arg Val Ile Arg Gln Ala Leu Asp Asn 
        275                 280                 285             


Ala Gly Leu Ser Ser Met Asp Val Asp Val Val Glu Gly His Gly Thr 
    290                 295                 300                 


Gly Thr Arg Leu Gly Asp Pro Ile Glu Ala Gln Ala Val Ile Ser Thr 
305                 310                 315                 320 


Tyr Gly Gln Asp Arg Glu Arg Pro Leu Leu Leu Gly Ser Leu Lys Ser 
                325                 330                 335     


Asn Ile Gly His Ala Gln Ala Ala Ala Gly Val Ser Gly Val Ile Lys 
            340                 345                 350         


Met Val Met Ala Leu Arg His Gly Val Val Pro Gln Thr Leu His Val 
        355                 360                 365             


Asp Glu Pro Ser Arg His Val Asp Trp Ala Ala Gly Ala Val Glu Leu 
    370                 375                 380                 


Val Thr Glu Asn Gln Pro Trp Pro Val Ala Glu Arg Ala Arg Arg Ala 
385                 390                 395                 400 


Gly Val Ser Ser Phe Gly Ile Ser Gly Thr Asn Ala His Val Ile Leu 
                405                 410                 415     


Glu Ser Ala Pro Ala Glu Ala Ala Ser Ala Ser Glu Pro Val Thr Pro 
            420                 425                 430         


Pro Ser Glu Val Ser Val Pro Val Val Ala Ser Asp Val Val Pro Leu 
        435                 440                 445             


Val Val Ser Ala Lys Thr Pro Gly Ala Leu Thr Asp Ile Glu Glu Arg 
    450                 455                 460                 


Leu Arg Gly Tyr Leu Ala Ala Ala Pro Glu Ala Asp Met Gln Ala Val 
465                 470                 475                 480 


Ala Ser Thr Leu Ala Ala Thr Arg Ser Val Phe Glu His Arg Ala Val 
                485                 490                 495     


Leu Leu Gly Asp Asp Thr Ile Thr Gly Ile Ala Thr Pro Asp Pro Arg 
            500                 505                 510         


Val Val Phe Val Phe Pro Gly Gln Gly Trp Gln Trp Leu Gly Met Gly 
        515                 520                 525             


Ser Val Leu Arg Glu Thr Ser Pro Val Phe Ala Gly Arg Met Ala Glu 
    530                 535                 540                 


Cys Ala Ala Ala Leu Arg Glu Phe Val Asp Trp Asp Leu Phe Ser Val 
545                 550                 555                 560 


Leu Asp Asp Pro Thr Val Val Asp Arg Val Asp Val Leu Gln Pro Ala 
                565                 570                 575     


Cys Trp Ala Val Met Val Ser Leu Ala Ala Val Trp Gln Glu Ala Gly 
            580                 585                 590         


Val Ser Pro Asp Ala Val Ile Gly His Ser Gln Gly Glu Ile Ala Ala 
        595                 600                 605             


Ala Cys Val Ala Gly Ala Val Ser Leu Arg Asp Ala Ala Arg Ile Val 
    610                 615                 620                 


Ala Leu Arg Ser Lys Leu Ile Gly Ala Arg Leu Gly His Gly Ala Met 
625                 630                 635                 640 


Ala Ser Ile Ala Leu Pro Ala Asp Ala Ile Thr Leu Thr Asp Gly Ala 
                645                 650                 655     


Trp Ile Ala Ala His Asn Gly Pro Ala Ser Thr Val Ile Ala Gly Thr 
            660                 665                 670         


Pro Gln Ala Val Asp Thr Val Leu Ala Ala Tyr Glu Ala Gln Gly Ile 
        675                 680                 685             


Arg Val Arg Arg Ile Thr Val Asp Tyr Ala Ser His Ser Pro Gln Val 
    690                 695                 700                 


Glu Glu Ile His Thr Glu Leu Leu Asp Ala Thr Ala Thr Val Gly Ser 
705                 710                 715                 720 


Gln Thr Pro Ala Val Pro Trp Leu Ser Thr Val Asp Gly Ala Trp Val 
                725                 730                 735     


Glu Gly Pro Leu Asp Ala Asp Tyr Trp Tyr Arg Asn Leu Arg Glu Pro 
            740                 745                 750         


Val Arg Phe Asp Gln Ala Val Thr His Leu Gln Thr Gln Gly Glu Thr 
        755                 760                 765             


Val Phe Ile Glu Val Ser Ala Ser Pro Ala Leu Thr Pro Ala Met Asn 
    770                 775                 780                 


Asp Asp Ala Ile Thr Val Ala Thr Leu Arg Arg Asp Asp Asp Ser Pro 
785                 790                 795                 800 


Thr Arg Ile Leu Thr Ala Leu Ala Glu Ala Phe Val Gln Gly Val Gly 
                805                 810                 815     


Val Asp Trp Pro Ala Val Thr Gly Ala Thr Thr Ala Arg Val Leu Asp 
            820                 825                 830         


Leu Pro Thr Tyr Ala Phe Gln Arg Gln Arg Tyr Trp Thr Leu Ser Gly 
        835                 840                 845             


Leu Ala Ala Ala Glu Arg Arg Gln Ala Leu Ala Lys Leu Val Arg Glu 
    850                 855                 860                 


Ser Ala Ala Val Val Leu Gly His Ala Asp Pro Asp Ser Val Pro Ala 
865                 870                 875                 880 


Ala Ala Ala Phe Lys Asp Leu Gly Val Asp Ser Leu Thr Ala Val Glu 
                885                 890                 895     


Leu Arg Asn Ser Leu Gly Arg Ser Thr Gly Leu Arg Leu Pro Ala Thr 
            900                 905                 910         


Met Val Phe Asp Tyr Pro Thr Pro Asp Ala Leu Ala Ala Arg Leu Asp 
        915                 920                 925             


<210>  69
<211>  901
<212>  PRT
<213>  Streptomyces hygroscopicus

<400>  69

Glu Pro Leu Ala Ile Val Gly Met Ala Cys Arg Leu Pro Gly Gly Val 
1               5                   10                  15      


Asp Ser Pro Glu Asp Leu Trp Arg Leu Val Glu Ser Gly Thr Asp Ala 
            20                  25                  30          


Ile Ser Gly Phe Pro Thr Asp Arg Gly Trp Asp Leu Asp Ser Leu Tyr 
        35                  40                  45              


Asp Pro Ile Leu Gly Ala Ser Gly Glu Phe Tyr Ser Ala Gln Gly Gly 
    50                  55                  60                  


Phe Leu Asp Arg Ala Ala Asp Phe Asp Ala Ser Phe Phe Gly Ile Ser 
65                  70                  75                  80  


Pro Arg Glu Ala Leu Ala Met Asp Pro Gln Gln Arg Leu Val Leu Glu 
                85                  90                  95      


Val Ser Trp Glu Ala Leu Glu Arg Ala Gly Ile Glu Ala Ser Ser Val 
            100                 105                 110         


Arg Gly Ser Asp Thr Gly Val Phe Met Gly Ala Met Ala Asn Gly Tyr 
        115                 120                 125             


Gly Ile Gly Ala Asp Phe Gly Ala Phe Gly Met Thr Ala Ser Ala Gly 
    130                 135                 140                 


Ser Val Leu Ser Gly Arg Val Ser Tyr Phe Phe Gly Leu Glu Gly Pro 
145                 150                 155                 160 


Ala Met Thr Val Asp Thr Ala Cys Ser Ser Ser Leu Val Ala Leu His 
                165                 170                 175     


Gln Ala Gly Tyr Ser Leu Arg Gln Gly Glu Cys Ser Met Ala Leu Val 
            180                 185                 190         


Gly Gly Val Thr Val Met Pro Thr Pro Gln Thr Phe Val Glu Phe Ala 
        195                 200                 205             


Arg Glu Arg Gly Leu Ala Val Asp Gly Arg Ser Lys Ala Phe Ala Asp 
    210                 215                 220                 


Ala Ala Asp Gly Ser Gly Phe Ser Glu Gly Val Gly Val Leu Val Val 
225                 230                 235                 240 


Glu Arg Leu Ser Asp Ala Arg Ala Arg Gly His Arg Val Leu Ala Val 
                245                 250                 255     


Val Arg Gly Ser Ala Val Asn Gln Asp Gly Ala Ser Asn Gly Leu Ser 
            260                 265                 270         


Ala Pro Asn Gly Pro Ser Gln Gln Arg Val Ile Arg Gln Ala Leu Ala 
        275                 280                 285             


Asn Ala Gly Leu Ala Ser Ala Asp Val Asp Val Val Glu Ala His Gly 
    290                 295                 300                 


Thr Gly Thr Arg Leu Gly Asp Pro Ile Glu Ala Gln Ala Val Ile Glu 
305                 310                 315                 320 


Thr Tyr Gly Gln Asp Arg Glu Arg Pro Leu Leu Leu Gly Ser Leu Lys 
                325                 330                 335     


Ser Asn Ile Gly His Thr Gln Ala Ala Ala Gly Val Ser Ala Val Ile 
            340                 345                 350         


Lys Met Val Met Ala Leu Arg His Gly Val Val Pro Gln Thr Leu His 
        355                 360                 365             


Val Asp Glu Pro Ser Arg His Val Asp Trp Thr Ala Gly Ala Val Glu 
    370                 375                 380                 


Leu Ala Thr Glu Lys Leu Pro Trp Pro Ala Ser Asp Arg Val Arg Arg 
385                 390                 395                 400 


Ala Gly Val Ser Ser Phe Gly Ile Ser Gly Thr Asn Ala His Val Ile 
                405                 410                 415     


Leu Glu Ser Val Pro Ala Glu Val Val Ser Pro Ser Glu Ser Ser Gly 
            420                 425                 430         


Pro Asn Leu Ala Ser Asp Val Val Pro Leu Val Val Ser Ala Lys Thr 
        435                 440                 445             


Ser Gly Ala Leu Val Asp Ile Glu Glu Arg Leu Arg Gly Tyr Leu Ala 
    450                 455                 460                 


Ala Val Pro Gly Val Asp Leu Gly Ala Val Ala Ser Val Leu Ala Gly 
465                 470                 475                 480 


Ser Arg Ser Val Phe Gly His Arg Gly Val Leu Val Gly Gly Glu Leu 
                485                 490                 495     


Val Ser Gly Val Ala Leu Ser Gly Pro Arg Val Val Phe Val Phe Ser 
            500                 505                 510         


Gly Gln Gly Ser Gln Cys Val Gly Met Gly Glu Arg Leu Ala Gly Val 
        515                 520                 525             


Phe Pro Val Phe Ala Glu Val Tyr Gly Arg Val Trp Asp Leu Leu Asp 
    530                 535                 540                 


Val Pro Gly Ser Gly Leu Gly Val Asp Asp Thr Gly Phe Val Gln Pro 
545                 550                 555                 560 


Ala Leu Phe Ala Leu Gln Val Gly Leu Phe Gly Leu Leu Glu Ser Trp 
                565                 570                 575     


Gly Val Arg Pro Glu Val Val Val Gly His Ser Val Gly Glu Val Ala 
            580                 585                 590         


Ala Gly Tyr Val Ala Gly Leu Trp Ser Leu Glu Asp Ala Cys Val Leu 
        595                 600                 605             


Val Ser Ala Arg Ala Arg Leu Met Gln Gly Leu Pro Gly Gly Gly Val 
    610                 615                 620                 


Met Val Ser Val Ser Val Ser Glu Glu Arg Ala Arg Ala Ala Leu Val 
625                 630                 635                 640 


Glu Gly Val Glu Ile Ala Ala Val Asn Gly Pro Ser Ser Val Val Leu 
                645                 650                 655     


Ser Gly Asp Glu Ala Ala Val Val Gly Val Ala Glu Gly Leu Gly Gly 
            660                 665                 670         


Arg Trp Arg Arg Leu Ala Thr Ser His Ala Phe His Ser Ala Arg Met 
        675                 680                 685             


Asp Pro Met Leu Asp Glu Phe Arg Val Val Ala Glu Gly Leu Glu Tyr 
    690                 695                 700                 


Arg Glu Pro Arg Ile Val Met Ala Gly Gly Ala Gly Val Val Ser Pro 
705                 710                 715                 720 


Glu Tyr Trp Val Arg Gln Val Arg Asp Thr Val Arg Phe Gly Asp Gln 
                725                 730                 735     


Val Ala Ala Tyr Gln Gly Asp Ala Val Phe Val Glu Val Gly Pro Gly 
            740                 745                 750         


Gly Ser Leu Ala Arg Leu Ile Asp Gly Val Ala Val Gly Asp Gly Glu 
        755                 760                 765             


Asp Glu Val Arg Ala Ala Val Met Ala Val Ala Glu Leu Phe Val Arg 
    770                 775                 780                 


Gly Val Asp Val Asp Trp Pro Ala Val Val Gly Thr Thr Ala Thr Pro 
785                 790                 795                 800 


Val Asp Leu Pro Thr Tyr Pro Phe Gln Arg Gln Arg Tyr Trp Thr Ala 
                805                 810                 815     


Ser Trp Leu Val Ala Leu Glu Pro Glu Glu Arg Gly Gln Ala Leu Leu 
            820                 825                 830         


Arg Met Val Arg Glu Gly Ala Ser Val Val Leu Gly His Ala Asp Ala 
        835                 840                 845             


Arg Ala Val Glu Val Asp Arg Ala Phe Arg Asp Leu Gly Val Asp Ser 
    850                 855                 860                 


Leu Thr Ala Val Gln Val Arg Asn Asn Leu Ala Lys Ala Thr Gly Leu 
865                 870                 875                 880 


Arg Leu Pro Ala Thr Met Val Phe Asp Tyr Pro Thr Pro Ala Ala Leu 
                885                 890                 895     


Ala Ala Arg Leu Asp 
            900     


<210>  70
<211>  901
<212>  PRT
<213>  Streptomyces hygroscopicus

<400>  70

Glu Pro Leu Ala Ile Val Gly Met Ala Cys Arg Leu Pro Gly Gly Val 
1               5                   10                  15      


Ala Ser Pro Glu Asp Leu Trp Arg Leu Val Glu Ser Gly Thr Asp Val 
            20                  25                  30          


Ile Ser Gly Phe Pro Thr Asp Arg Gly Trp Asp Leu Asp Asn Leu Tyr 
        35                  40                  45              


Asp Pro Asp Pro Ala Val Gly Lys Ser Tyr Cys Val Gln Gly Tyr Phe 
    50                  55                  60                  


Leu Asp Asp Val Ala Asp Phe Asp Ala Ser Phe Phe Gly Ile Ser Pro 
65                  70                  75                  80  


Arg Glu Ala Leu Ala Met Asp Pro Gln Gln Arg Leu Ile Leu Glu Ala 
                85                  90                  95      


Ser Trp Glu Ala Phe Glu Arg Ala Gly Ile Glu Pro Gly Ser Val Arg 
            100                 105                 110         


Gly Ser Asp Thr Gly Val Phe Met Gly Ala Phe Ser Ser Gly Tyr Gly 
        115                 120                 125             


Ile Gly Ala Asp His Ser Gly Phe Gly Met Thr Ala Gly Ala Gly Ser 
    130                 135                 140                 


Val Leu Ser Gly Arg Ile Ser Tyr Leu Phe Gly Leu Glu Gly Pro Ala 
145                 150                 155                 160 


Met Thr Val Asp Thr Ala Cys Ser Ser Ser Leu Val Ala Leu His Gln 
                165                 170                 175     


Ala Ser Ser Ala Leu Arg Gln Gly Glu Cys Ser Leu Ala Leu Val Gly 
            180                 185                 190         


Gly Val Thr Val Met Pro Thr Pro Gln Thr Phe Leu Glu Phe Ala Arg 
        195                 200                 205             


Gln Arg Gly Leu Ala Ala Asp Gly Arg Ser Lys Ala Phe Ser Asp Ala 
    210                 215                 220                 


Ala Asp Gly Ser Gly Phe Ser Glu Gly Val Gly Val Leu Val Val Glu 
225                 230                 235                 240 


Arg Leu Ser Asp Ala Arg Ala Arg Gly His Arg Val Leu Ala Val Val 
                245                 250                 255     


Arg Gly Ser Ala Val Asn Gln Asp Gly Ala Ser Asn Gly Leu Ser Ala 
            260                 265                 270         


Pro Asn Gly Pro Ser Gln Gln Arg Val Ile Arg Gln Ala Leu Ala Asn 
        275                 280                 285             


Ala Gly Leu Ser Ser Ala Asp Val Asp Val Val Glu Ala His Gly Thr 
    290                 295                 300                 


Gly Thr Arg Leu Gly Asp Pro Ile Glu Ala Gln Ala Val Ile Glu Thr 
305                 310                 315                 320 


Tyr Gly Gln Asp Arg Glu Arg Pro Leu Leu Leu Gly Ser Leu Lys Ser 
                325                 330                 335     


Asn Ile Gly His Thr Gln Ala Ala Ala Gly Val Ser Ala Val Ile Lys 
            340                 345                 350         


Met Val Met Ala Leu Arg His Gly Val Val Pro Gln Thr Leu His Val 
        355                 360                 365             


Asp Glu Pro Ser Arg His Val Asp Trp Thr Ala Gly Ala Val Gln Leu 
    370                 375                 380                 


Ala Thr Glu Lys Gln Pro Trp Pro Ala Ser Asp Arg Ala Arg Arg Ala 
385                 390                 395                 400 


Gly Val Ser Ser Phe Gly Ile Ser Gly Thr Asn Ala His Val Ile Leu 
                405                 410                 415     


Glu Ser Ala Pro Val His Ser Val Glu Thr Asp Glu Thr Ala Pro Met 
            420                 425                 430         


Ala Leu Ala Ser Asp Val Val Pro Leu Val Val Ser Ala Lys Thr Ser 
        435                 440                 445             


Gly Ala Leu Val Asp Ile Glu Glu Arg Leu Arg Gly Tyr Leu Ala Val 
    450                 455                 460                 


Ala Gly Ser Glu Val Asp Leu Gly Ala Val Ala Ser Val Leu Ala Gly 
465                 470                 475                 480 


Ser Arg Ser Val Phe Gly His Arg Gly Val Leu Val Gly Gly Glu Leu 
                485                 490                 495     


Val Ser Gly Val Ala Leu Ser Gly Pro Arg Val Val Phe Val Phe Ser 
            500                 505                 510         


Gly Gln Gly Ser Gln Cys Val Gly Met Gly Glu Arg Leu Ala Gly Val 
        515                 520                 525             


Phe Pro Val Phe Ala Glu Val Tyr Gly Arg Val Trp Asp Leu Leu Asp 
    530                 535                 540                 


Val Pro Gly Ser Gly Leu Gly Val Asp Asp Thr Gly Phe Val Gln Pro 
545                 550                 555                 560 


Ala Leu Phe Ala Leu Gln Val Gly Leu Phe Gly Leu Leu Glu Ser Trp 
                565                 570                 575     


Gly Val Arg Pro Glu Val Val Val Gly His Ser Val Gly Glu Val Ala 
            580                 585                 590         


Ala Gly Tyr Val Ala Gly Leu Trp Ser Leu Glu Asp Ala Cys Val Leu 
        595                 600                 605             


Val Ser Ala Arg Ala Arg Leu Met Gln Gly Leu Pro Gly Gly Gly Val 
    610                 615                 620                 


Met Val Ser Val Ser Val Ser Glu Glu Arg Ala Arg Ala Ala Leu Val 
625                 630                 635                 640 


Glu Gly Val Glu Ile Ala Ala Val Asn Gly Pro Ser Ser Val Val Leu 
                645                 650                 655     


Ser Gly Asp Glu Ala Ala Val Val Gly Val Ala Glu Gly Leu Gly Gly 
            660                 665                 670         


Arg Trp Arg Arg Leu Ala Thr Ser His Ala Phe His Ser Ala Arg Met 
        675                 680                 685             


Asp Pro Met Leu Asp Glu Phe Arg Val Val Ala Glu Gly Leu Glu Tyr 
    690                 695                 700                 


Arg Glu Pro Arg Ile Val Met Ala Gly Gly Ala Gly Val Val Ser Pro 
705                 710                 715                 720 


Glu Tyr Trp Val Arg Gln Val Arg Asp Thr Val Arg Phe Gly Asp Gln 
                725                 730                 735     


Val Ala Ala Tyr Gln Gly Asp Ala Val Phe Val Glu Val Gly Pro Gly 
            740                 745                 750         


Gly Ser Leu Ala Arg Leu Ile Asp Gly Val Ala Val Gly Asp Gly Glu 
        755                 760                 765             


Asp Glu Val Arg Ala Ala Val Met Ala Val Ala Glu Leu Phe Val Arg 
    770                 775                 780                 


Gly Val Asp Val Asp Trp Pro Ala Val Val Gly Thr Thr Ala Ala Pro 
785                 790                 795                 800 


Val Asp Leu Pro Thr Tyr Pro Phe Gln Arg Gln Arg Tyr Trp Thr Gln 
                805                 810                 815     


Thr Trp Leu Thr Gly Leu Ala Ser Glu Asp Arg Arg Gln Ala Leu Leu 
            820                 825                 830         


Lys Val Val Arg Asp Ser Ala Ala Thr Val Leu Gly His Ala Asp Ala 
        835                 840                 845             


Gly Met Ile Pro Ala Thr Ala Ala Phe Lys Asp Leu Gly Leu Asp Ser 
    850                 855                 860                 


Leu Thr Ala Val Glu Leu Arg Asn Ser Leu Gly Lys Ser Thr Gly Leu 
865                 870                 875                 880 


Ser Leu Pro Ala Thr Met Val Phe Asp Tyr Pro Thr Pro Asp Ala Leu 
                885                 890                 895     


Ala Asp Arg Leu Asp 
            900     


<210>  71
<211>  926
<212>  PRT
<213>  Streptomyces hygroscopicus

<400>  71

Glu Pro Leu Ala Ile Val Gly Met Ala Cys Arg Leu Pro Gly Gly Val 
1               5                   10                  15      


Ala Ser Pro Glu Asp Leu Trp Arg Leu Val Glu Ser Gly Thr Asp Ala 
            20                  25                  30          


Ile Ser Asp Phe Pro Thr Asp Arg Gly Trp Asp Val Glu Gly Leu Tyr 
        35                  40                  45              


Asp Pro Asp Pro Asp Ala Pro Gly Lys Ser Tyr Ala Val Lys Gly Gly 
    50                  55                  60                  


Phe Leu Asp Ala Ala Gly Phe Asp Ala Ala Phe Phe Gly Ile Ser Pro 
65                  70                  75                  80  


Arg Glu Ala Leu Ala Met Asp Pro Gln Gln Arg Leu Val Leu Glu Ala 
                85                  90                  95      


Ser Trp Glu Ala Phe Glu Arg Ala Gly Ile Glu Pro Gly Ser Val Arg 
            100                 105                 110         


Gly Ser Asp Thr Gly Val Phe Met Gly Ala Phe Pro Ala Gly Tyr Gly 
        115                 120                 125             


Gly Asp Arg Glu Gly Phe Gly Ala Thr Ala Gly Ala Gly Ser Val Leu 
    130                 135                 140                 


Ser Gly Arg Val Ser Tyr Phe Phe Gly Leu Glu Gly Pro Ala Ile Thr 
145                 150                 155                 160 


Val Asp Thr Ala Cys Ser Ser Ser Leu Val Ala Leu His Gln Ala Gly 
                165                 170                 175     


Tyr Ser Leu Arg Gln Gly Glu Cys Ser Leu Ala Leu Val Gly Gly Ala 
            180                 185                 190         


Thr Val Met Ala Thr Pro Gln Thr Phe Val Glu Phe Ser Arg Gln Arg 
        195                 200                 205             


Gly Leu Ser Val Asp Gly Arg Ser Lys Ala Phe Ala Asp Ala Ala Asp 
    210                 215                 220                 


Gly Thr Gly Trp Ala Glu Gly Val Gly Val Leu Val Val Glu Arg Leu 
225                 230                 235                 240 


Ser Asp Ala Gln Ala Lys Gly His Gln Val Leu Ala Val Val Arg Gly 
                245                 250                 255     


Ser Ala Val Asn Gln Asp Gly Ala Ser Asn Gly Leu Thr Ala Pro Asn 
            260                 265                 270         


Gly Pro Ser Gln Gln Arg Val Ile Arg Gln Ala Leu Ala Asn Ala Gly 
        275                 280                 285             


Leu Ser Ser Ala Asp Val Asp Val Val Glu Ala His Gly Thr Gly Thr 
    290                 295                 300                 


Lys Leu Gly Asp Pro Ile Glu Ala Gln Ala Val Ile Ala Thr Tyr Gly 
305                 310                 315                 320 


Gln Asp Arg Glu Arg Pro Leu Leu Leu Gly Ser Leu Lys Ser Asn Ile 
                325                 330                 335     


Gly His Thr Gln Ala Ala Ala Gly Val Ser Gly Val Ile Lys Met Val 
            340                 345                 350         


Met Ala Leu Gln His Gly Val Val Pro Gln Thr Leu His Val Asp Glu 
        355                 360                 365             


Pro Ser Arg His Val Asp Trp Ala Ala Gly Ala Val Glu Leu Val Thr 
    370                 375                 380                 


Glu Asn Gln Pro Trp Pro Val Ala Glu Arg Ala Arg Arg Ala Gly Val 
385                 390                 395                 400 


Ser Ser Phe Gly Ile Ser Gly Thr Asn Ala His Val Ile Leu Glu Ser 
                405                 410                 415     


Ala Pro Ala Glu Ala Ala Ser Ala Ser Glu Pro Val Thr Pro Pro Ser 
            420                 425                 430         


Glu Ala Ser Val Pro Val Val Ala Ser Asp Val Val Pro Leu Val Val 
        435                 440                 445             


Ser Ala Lys Thr Pro Gly Ala Leu Thr Asp Ile Glu Glu Arg Leu Arg 
    450                 455                 460                 


Gly Tyr Leu Ala Ala Ala Ser Asp Val Asp Met Ala Ala Ala Ala Ser 
465                 470                 475                 480 


Thr Leu Ala Ala Thr Arg Ser Val Phe Glu His Arg Ala Val Leu Leu 
                485                 490                 495     


Gly Asp Asp Thr Ile Thr Gly Ile Ala Thr Pro Asp Pro Arg Val Val 
            500                 505                 510         


Phe Val Phe Pro Gly Gln Gly Trp Gln Trp Leu Gly Met Gly Ser Val 
        515                 520                 525             


Leu Arg Glu Thr Ser Pro Val Phe Ala Gly Arg Met Ala Glu Cys Ala 
    530                 535                 540                 


Ala Ala Leu Gly Glu Phe Val Asp Trp Asp Leu Phe Ser Val Leu Asp 
545                 550                 555                 560 


Asp Pro Thr Val Val Asp Arg Val Asp Val Leu Gln Pro Ala Cys Trp 
                565                 570                 575     


Ala Val Met Val Ser Leu Ala Ala Val Trp Gln Glu Ala Gly Val Ser 
            580                 585                 590         


Pro Asp Ala Val Ile Gly His Ser Gln Gly Glu Ile Ala Ala Ala Cys 
        595                 600                 605             


Val Ala Gly Ala Val Ser Leu Arg Asp Ala Ala Arg Ile Val Ala Leu 
    610                 615                 620                 


Arg Ser Lys Leu Ile Gly Ala Arg Leu Gly His Gly Ala Met Ala Ser 
625                 630                 635                 640 


Ile Ala Leu Pro Ala Gly Asp Val Ala Leu Val Asp Gly Ala Trp Ile 
                645                 650                 655     


Ala Ala His Asn Gly Pro Ala Ser Thr Val Ile Ala Gly Thr Pro Gln 
            660                 665                 670         


Ala Val Asp Thr Val Leu Ala Ala His Glu Ala Gln Gly Ile Arg Val 
        675                 680                 685             


Arg Arg Ile Thr Val Asp Tyr Ala Ser His Ser Pro Gln Val Glu Glu 
    690                 695                 700                 


Ile His Ala Glu Leu Leu Asp Ala Thr Ala Ala Val Gly Ser Gln Ala 
705                 710                 715                 720 


Pro Ala Val Pro Trp Leu Ser Thr Val Asp Gly Ala Trp Val Glu Gly 
                725                 730                 735     


Pro Leu Asp Ala Asp Tyr Trp Tyr Arg Asn Leu Arg Glu Pro Val Arg 
            740                 745                 750         


Phe Asp Gln Ala Val Thr Leu Leu Gln Thr Gln Gly Glu Thr Val Phe 
        755                 760                 765             


Ile Glu Val Ser Ala Ser Pro Ala Leu Thr Pro Ala Met Asn Asp Asp 
    770                 775                 780                 


Ala Ile Thr Val Ala Thr Leu Arg Arg Asp Asp Asp Ser Pro Ala Arg 
785                 790                 795                 800 


Ile Leu Thr Ala Leu Ala Glu Ala Phe Val Gln Gly Val Gly Val Asp 
                805                 810                 815     


Trp Pro Ala Val Thr Gly Ala Thr Thr Ser Arg Val Asp Leu Pro Thr 
            820                 825                 830         


Tyr Pro Phe Gln His Gln Arg Tyr Trp Ala Trp Leu Ala Gly Leu Ala 
        835                 840                 845             


Pro Glu Ala Arg Gly Gln Ala Leu Leu Lys Val Val Arg Glu Ser Ala 
    850                 855                 860                 


Ala Val Val Leu Gly His Thr Gly Ala Asp Thr Val Pro Val Thr Ala 
865                 870                 875                 880 


Ala Phe Lys Asp Leu Gly Leu Asp Ser Leu Thr Ala Val Glu Leu Arg 
                885                 890                 895     


Asn Ser Leu Gly Arg Ser Thr Gly Leu Arg Leu Pro Val Thr Ala Val 
            900                 905                 910         


Phe Asp Tyr Pro Thr Pro Ala Ala Leu Ala Ala Arg Leu Asp 
        915                 920                 925     


<210>  72
<211>  923
<212>  PRT
<213>  Streptomyces hygroscopicus

<400>  72

Glu Pro Leu Ala Ile Val Gly Met Ala Cys Arg Leu Pro Gly Gly Val 
1               5                   10                  15      


Ala Ser Pro Glu Asp Leu Trp Arg Leu Val Glu Ser Gly Arg Asp Val 
            20                  25                  30          


Ile Ser Asp Phe Pro Val Asp Arg Gly Trp Asp Leu Asp Asn Leu Tyr 
        35                  40                  45              


Asp Pro Asp Pro Ala Val Gly Lys Thr Tyr Cys Lys Arg Gly Gly Phe 
    50                  55                  60                  


Leu Asp Ala Ala Ala Glu Phe Asp Ala Ala Phe Phe Gly Ile Ser Pro 
65                  70                  75                  80  


Arg Glu Ala Ala Ala Met Asp Pro Gln Gln Arg Leu Val Leu Glu Ala 
                85                  90                  95      


Ser Trp Glu Ala Phe Glu Arg Ala Gly Ile Glu Pro Gly Ser Val Arg 
            100                 105                 110         


Gly Ser Asp Thr Gly Val Phe Met Gly Ala Phe Ala Asn Glu Tyr Gly 
        115                 120                 125             


Ala Gly Ala Asp Phe Gly Ala Phe Gly Met Thr Ala Gly Ala Gly Ser 
    130                 135                 140                 


Val Leu Ser Gly Arg Val Ser Tyr Leu Phe Gly Leu Glu Gly Pro Ala 
145                 150                 155                 160 


Met Thr Val Asp Thr Ala Cys Ser Ser Ser Leu Val Ala Leu His Gln 
                165                 170                 175     


Ala Gly Ser Ala Leu Arg Gln Gly Glu Cys Ser Leu Ala Leu Val Gly 
            180                 185                 190         


Gly Val Thr Val Met Pro Thr Pro Gln Leu Phe Val Gly Phe Ala Arg 
        195                 200                 205             


Glu Arg Gly Leu Ala Val Asp Gly Arg Ser Lys Ala Phe Ser Asp Ala 
    210                 215                 220                 


Ala Asp Gly Ala Gly Trp Ala Glu Gly Val Gly Val Leu Val Val Glu 
225                 230                 235                 240 


Arg Leu Ser Asp Ala Gln Ala Arg Gly His Arg Val Leu Ala Val Val 
                245                 250                 255     


Arg Gly Ser Ala Val Asn Gln Asp Gly Ala Ser Asn Gly Leu Thr Ala 
            260                 265                 270         


Pro Asn Gly Pro Ser Gln Gln Arg Val Ile Arg Gln Ala Leu Ala Asn 
        275                 280                 285             


Ala Gly Leu Ser Ser Ala Asp Val Asp Val Val Glu Ala His Gly Thr 
    290                 295                 300                 


Gly Thr Arg Leu Gly Asp Pro Ile Glu Ala Gln Ala Val Ile Ala Thr 
305                 310                 315                 320 


Tyr Gly Gln Asp Arg Glu Arg Pro Leu Leu Leu Gly Ser Leu Lys Ser 
                325                 330                 335     


Asn Ile Gly His Thr Gln Ala Ala Ala Gly Val Ser Gly Val Ile Lys 
            340                 345                 350         


Met Val Met Ala Leu Arg His Ser Val Val Pro Arg Thr Leu His Val 
        355                 360                 365             


Asp Glu Pro Ser Arg His Val Asp Trp Ala Ala Gly Ala Val Glu Leu 
    370                 375                 380                 


Val Thr Glu Lys Gln Pro Trp Pro Thr Ser Asp Arg Ala Arg Arg Ala 
385                 390                 395                 400 


Gly Val Ser Ser Phe Gly Ile Ser Gly Thr Asn Ala His Val Ile Leu 
                405                 410                 415     


Glu Ser Ala Pro Ala Gln Pro Leu Glu Thr Asp Glu Ala Leu Val Pro 
            420                 425                 430         


Val Val Ala Ser Asp Val Met Pro Leu Val Val Ser Ala Lys Thr Pro 
        435                 440                 445             


Asp Ala Leu Thr Asp Ile Glu Asp Arg Leu Arg Ala His Leu Ala Ala 
    450                 455                 460                 


Ala Pro Glu Ala Asp Met Gln Ala Val Ala Ser Thr Leu Ala Ala Thr 
465                 470                 475                 480 


Arg Ser Val Phe Glu His Arg Ala Val Leu Leu Gly Asp Asp Thr Ile 
                485                 490                 495     


Thr Gly Val Ala Ala Ser Gly Pro Arg Val Val Phe Val Phe Pro Gly 
            500                 505                 510         


Gln Gly Trp Gln Trp Leu Gly Met Gly Ser Val Leu Arg Glu Thr Ser 
        515                 520                 525             


Pro Val Phe Ala Gly Arg Met Ala Glu Cys Ala Ala Ala Leu Arg Glu 
    530                 535                 540                 


Phe Val Asp Trp Asp Leu Phe Ser Val Leu Asp Asp Pro Thr Val Val 
545                 550                 555                 560 


Asp Arg Val Asp Val Leu Gln Pro Ala Cys Trp Ala Val Met Val Ser 
                565                 570                 575     


Leu Ala Ala Val Trp Gln Glu Ala Gly Val Ser Pro Asp Ala Val Ile 
            580                 585                 590         


Gly His Ser Gln Gly Glu Ile Ala Ala Ala Cys Val Ala Gly Ala Val 
        595                 600                 605             


Ser Leu Gln Asp Ala Ala Arg Ile Val Ala Leu Arg Ser Lys Leu Ile 
    610                 615                 620                 


Ala His Leu Ala Gly His Gly Ala Met Ala Ser Ile Ala Leu Pro Ala 
625                 630                 635                 640 


Asp Ala Ile Thr Leu Thr Asp Gly Ala Trp Ile Ala Ala His Asn Gly 
                645                 650                 655     


Thr Ala Ser Thr Val Ile Ala Gly Thr Pro Gln Ala Val Asp Thr Val 
            660                 665                 670         


Leu Ala Thr His Glu Ala Gln Gly Ile Arg Val Arg Arg Ile Thr Val 
        675                 680                 685             


Asp Tyr Ala Ser His Ser Pro Gln Val Glu Glu Ile His Thr Glu Leu 
    690                 695                 700                 


Leu Asp Ala Thr Ala Thr Val Gly Ser Gln Thr Pro Ala Val Pro Trp 
705                 710                 715                 720 


Leu Ser Thr Val Asp Asn Thr Trp Ile Ser Arg Pro Leu Asp Thr Asp 
                725                 730                 735     


Tyr Trp Tyr Arg Asn Leu Arg Glu Pro Val Arg Phe Asp Gln Ala Val 
            740                 745                 750         


Thr Leu Leu Gln Thr Gln Gly Glu Thr Val Phe Ile Glu Val Ser Ala 
        755                 760                 765             


Ser Pro Ala Leu Thr Pro Ala Met Asn Asp Asp Ala Val Thr Val Ala 
    770                 775                 780                 


Thr Leu Arg Arg Asp Asp Asp Ser Pro Thr Arg Ile Leu Thr Ala Leu 
785                 790                 795                 800 


Ala Glu Ala Phe Val Gln Gly Val Gly Val Asp Trp Pro Ala Val Thr 
                805                 810                 815     


Gly Ala Thr Thr Thr Pro Val Asp Leu Pro Thr Tyr Pro Phe Gln Arg 
            820                 825                 830         


Gln Arg Tyr Trp Thr Ala Ser Trp Leu Ala Gly Leu Ala Pro Glu Ala 
        835                 840                 845             


Arg Gly Gln Ala Leu Leu Lys Val Val Arg Glu Ser Thr Ala Val Val 
    850                 855                 860                 


Leu Gly His Val Asp Thr Glu Thr Val Pro Ala Thr Ala Pro Phe Lys 
865                 870                 875                 880 


Asp Leu Gly Leu Asp Ser Leu Thr Ala Val Gln Val Arg Asn Gly Leu 
                885                 890                 895     


Ala Lys Ala Thr Gly Leu Arg Leu Pro Ala Thr Met Val Phe Asp Tyr 
            900                 905                 910         


Pro Thr Pro Ala Ala Leu Ala Ala Arg Leu Asp 
        915                 920             


<210>  73
<211>  898
<212>  PRT
<213>  Streptomyces hygroscopicus

<400>  73

Glu Pro Leu Ala Ile Val Gly Met Ala Cys Arg Leu Pro Gly Gly Val 
1               5                   10                  15      


Ala Ser Pro Glu Asp Leu Trp Arg Leu Val Glu Ser Gly Thr Asp Ala 
            20                  25                  30          


Ile Ser Asp Phe Pro Thr Asp Arg Gly Trp Asp Val Glu Gly Leu Tyr 
        35                  40                  45              


Asp Pro Asp Pro Asp Val Pro Gly Lys Ser Tyr Ala Val Lys Gly Gly 
    50                  55                  60                  


Phe Leu Asp Ala Ala Gly Phe Asp Ala Ala Phe Phe Gly Ile Ser Pro 
65                  70                  75                  80  


Arg Glu Ala Leu Ala Met Asp Pro Gln Gln Arg Leu Val Leu Glu Ala 
                85                  90                  95      


Ser Trp Glu Ala Phe Glu Arg Ala Gly Ile Glu Pro Gly Ser Val Arg 
            100                 105                 110         


Gly Ser Asp Ile Gly Val Phe Met Gly Ala Met Ala Asn Glu Tyr Gly 
        115                 120                 125             


Ala Gly Ala Asp Phe Gly Ala Phe Gly Met Thr Ala Gly Ala Gly Ser 
    130                 135                 140                 


Val Leu Ser Gly Arg Val Ser Tyr Phe Phe Gly Leu Glu Gly Pro Ala 
145                 150                 155                 160 


Met Thr Val Asp Thr Ala Cys Ser Ser Ser Leu Val Ala Leu His Gln 
                165                 170                 175     


Ala Gly Ser Ala Leu Arg Gln Gly Glu Cys Ser Met Ala Leu Val Gly 
            180                 185                 190         


Gly Val Thr Val Met Pro Thr Pro Gln Thr Phe Val Glu Phe Ala Arg 
        195                 200                 205             


Gln Arg Gly Leu Ala Thr Asp Gly Arg Ser Lys Ala Phe Ala Asp Ala 
    210                 215                 220                 


Ala Asp Gly Ser Gly Phe Ser Glu Gly Val Gly Val Leu Val Val Glu 
225                 230                 235                 240 


Arg Leu Ser Asp Ala Arg Ala Arg Gly His Arg Val Leu Ala Val Val 
                245                 250                 255     


Arg Gly Ser Ala Val Asn Gln Asp Gly Ala Ser Asn Gly Leu Ser Ala 
            260                 265                 270         


Pro Asn Gly Pro Ser Gln Gln Arg Val Ile Arg Gln Ala Leu Ala Asn 
        275                 280                 285             


Ala Gly Leu Ala Ser Ala Asp Val Asp Val Val Glu Ala His Gly Thr 
    290                 295                 300                 


Gly Thr Arg Leu Gly Asp Pro Ile Glu Ala Gln Ala Val Ile Glu Thr 
305                 310                 315                 320 


Tyr Gly Gln Asp Arg Glu Arg Pro Leu Leu Leu Gly Ser Leu Lys Ser 
                325                 330                 335     


Asn Ile Gly His Thr Gln Ala Ala Ala Gly Val Ser Ala Val Ile Lys 
            340                 345                 350         


Met Val Met Ala Leu Arg His Gly Val Val Pro Gln Thr Leu His Val 
        355                 360                 365             


Asp Glu Pro Ser Arg His Val Asp Trp Thr Ala Gly Ala Val Gln Leu 
    370                 375                 380                 


Ala Thr Glu Lys Gln Pro Trp Pro Ala Ser Asp Arg Ala Arg Arg Ala 
385                 390                 395                 400 


Gly Val Ser Ser Phe Gly Ile Ser Gly Thr Asn Ala His Val Ile Leu 
                405                 410                 415     


Glu Ser Ala Pro Val His Ser Val Glu Thr Asp Glu Thr Ala Pro Met 
            420                 425                 430         


Ala Leu Ala Ser Asp Val Val Pro Leu Val Val Ser Ala Lys Thr Ser 
        435                 440                 445             


Gly Ala Leu Val Asp Ile Glu Glu Arg Leu Arg Gly Tyr Leu Ala Ala 
    450                 455                 460                 


Val Pro Gly Val Asp Leu Gly Ala Val Ala Ser Val Leu Ala Gly Ser 
465                 470                 475                 480 


Arg Ser Val Phe Gly His Arg Gly Val Leu Val Gly Gly Glu Leu Val 
                485                 490                 495     


Ser Gly Val Ala Leu Ser Gly Pro Arg Val Val Phe Val Phe Ser Gly 
            500                 505                 510         


Gln Gly Ser Gln Cys Val Gly Met Gly Glu Arg Leu Ala Gly Val Phe 
        515                 520                 525             


Pro Val Phe Ala Glu Val Tyr Gly Arg Val Trp Asp Leu Leu Asp Val 
    530                 535                 540                 


Pro Gly Ser Gly Leu Gly Val Asp Asp Thr Gly Phe Val Gln Pro Ala 
545                 550                 555                 560 


Leu Phe Ala Leu Gln Val Gly Leu Phe Gly Leu Leu Glu Ser Trp Gly 
                565                 570                 575     


Val Arg Pro Glu Val Val Val Gly His Ser Val Gly Glu Val Ala Ala 
            580                 585                 590         


Gly Tyr Val Ala Gly Leu Trp Ser Leu Glu Asp Ala Cys Val Leu Val 
        595                 600                 605             


Ser Ala Arg Ala Arg Leu Met Gln Gly Leu Pro Gly Gly Gly Val Met 
    610                 615                 620                 


Val Ser Val Ser Val Ser Glu Asp Arg Ala Arg Ala Ala Leu Val Glu 
625                 630                 635                 640 


Gly Val Glu Ile Ala Ala Val Asn Gly Pro Ser Ser Val Val Leu Ser 
                645                 650                 655     


Gly Asp Glu Ala Ala Val Val Gly Val Ala Glu Gly Leu Gly Gly Arg 
            660                 665                 670         


Trp Arg Arg Leu Ala Thr Ser His Ala Phe His Ser Ala Arg Met Asp 
        675                 680                 685             


Pro Met Leu Asp Glu Phe Arg Val Val Ala Glu Gly Leu Glu Tyr Arg 
    690                 695                 700                 


Glu Pro Arg Ile Val Met Ala Gly Gly Ala Gly Val Val Ser Pro Glu 
705                 710                 715                 720 


Tyr Trp Val Arg Gln Val Arg Asp Thr Val Arg Phe Gly Asp Gln Val 
                725                 730                 735     


Ala Ala Tyr Gln Gly Asp Ala Val Phe Val Glu Val Gly Pro Gly Gly 
            740                 745                 750         


Ser Leu Ala Arg Leu Ile Asp Gly Val Ala Val Gly Asp Gly Glu Asp 
        755                 760                 765             


Glu Val Arg Ala Ala Val Met Ala Val Ala Glu Leu Phe Val Arg Gly 
    770                 775                 780                 


Val Asp Val Asp Trp Pro Ala Val Val Gly Thr Thr Ala Thr Pro Val 
785                 790                 795                 800 


Asp Leu Pro Thr Tyr Pro Phe Gln Arg Gln Arg Tyr Trp Ala Trp Leu 
                805                 810                 815     


Thr Gly Leu Ala Ser Glu Asp Arg Arg Gln Ala Leu Leu Lys Val Val 
            820                 825                 830         


Arg Asp Ser Ala Ala Thr Val Leu Gly His Ala Asp Ala Arg Ala Val 
        835                 840                 845             


Glu Val Asp Arg Ala Phe Arg Asp Leu Gly Val Asp Ser Leu Thr Ala 
    850                 855                 860                 


Val Gln Val Arg Asn Asn Leu Ala Lys Ala Thr Gly Leu Arg Leu Pro 
865                 870                 875                 880 


Ala Thr Met Val Phe Asp Tyr Pro Thr Pro Ala Ala Leu Ala Ala Arg 
                885                 890                 895     


Leu Asp 
        


<210>  74
<211>  898
<212>  PRT
<213>  Streptomyces hygroscopicus

<400>  74

Glu Pro Leu Ala Ile Val Gly Met Ala Cys Arg Leu Pro Gly Gly Val 
1               5                   10                  15      


Ala Ser Pro Glu Asp Leu Trp Arg Leu Val Glu Ser Gly Thr Asp Ala 
            20                  25                  30          


Ile Ser Asp Phe Pro Thr Asp Arg Gly Trp Asp Val Glu Gly Leu Tyr 
        35                  40                  45              


Asp Pro Asp Pro Asp Val Pro Gly Lys Ser Tyr Ala Val Lys Gly Gly 
    50                  55                  60                  


Phe Leu Asp Ala Ala Gly Phe Asp Ala Ala Phe Phe Gly Ile Ser Pro 
65                  70                  75                  80  


Arg Glu Ala Leu Ala Met Asp Pro Gln Gln Arg Leu Val Leu Glu Ala 
                85                  90                  95      


Ser Trp Glu Ala Phe Glu Arg Ala Gly Ile Glu Pro Gly Ser Val Arg 
            100                 105                 110         


Gly Ser Asp Thr Gly Val Phe Met Gly Ala Phe Thr Asn Gly Tyr Gly 
        115                 120                 125             


Thr Gly Ala Asp Leu Asp Gly Phe Gly Ala Thr Ala Gly Thr Gly Ser 
    130                 135                 140                 


Val Leu Ser Gly Arg Val Ser Tyr Phe Phe Gly Leu Glu Gly Pro Ala 
145                 150                 155                 160 


Met Thr Val Asp Thr Ala Cys Ser Ser Ser Leu Val Ala Leu His Gln 
                165                 170                 175     


Ala Gly Tyr Ser Leu Arg Gln Gly Glu Cys Ser Met Ala Leu Val Gly 
            180                 185                 190         


Gly Val Thr Val Met Pro Thr Pro Gln Thr Phe Val Glu Phe Ala Arg 
        195                 200                 205             


Gln Arg Gly Leu Ala Thr Asp Gly Arg Ser Lys Ala Phe Ala Asp Ala 
    210                 215                 220                 


Ala Asp Gly Ser Gly Phe Ser Glu Gly Val Gly Val Leu Val Val Glu 
225                 230                 235                 240 


Arg Leu Ser Asp Ala Gln Ala Arg Gly His Arg Val Leu Ala Val Val 
                245                 250                 255     


Arg Gly Ser Ala Val Asn Gln Asp Gly Ala Ser Asn Gly Leu Thr Ala 
            260                 265                 270         


Pro Asn Gly Pro Ser Gln Gln Arg Val Ile Arg Gln Ala Leu Ala Asn 
        275                 280                 285             


Ala Gly Leu Ala Ser Ala Asp Val Asp Val Val Glu Ala His Gly Thr 
    290                 295                 300                 


Gly Thr Arg Leu Gly Asp Pro Ile Glu Ala Gln Ala Val Ile Glu Thr 
305                 310                 315                 320 


Tyr Gly Gln Asp Arg Glu Arg Pro Leu Leu Leu Gly Ser Leu Lys Ser 
                325                 330                 335     


Asn Ile Gly His Thr Gln Ala Ala Ala Gly Val Ser Gly Val Ile Lys 
            340                 345                 350         


Met Val Met Ala Leu Gln His Gly Val Val Pro Gln Thr Leu His Val 
        355                 360                 365             


Asp Glu Pro Ser Arg His Val Asp Trp Ser Ala Gly Ala Val Glu Leu 
    370                 375                 380                 


Ala Arg Glu Arg Gln Pro Trp Pro Val Ala Gly Arg Ala Arg Arg Ala 
385                 390                 395                 400 


Gly Val Ser Ser Phe Gly Ile Ser Gly Thr Asn Ala His Val Ile Leu 
                405                 410                 415     


Glu Ser Ala Pro Val His Ser Val Glu Thr Asp Glu Thr Ala Pro Met 
            420                 425                 430         


Ala Leu Ala Ser Asp Val Val Pro Leu Val Val Ser Ala Lys Thr Ser 
        435                 440                 445             


Gly Ala Leu Val Asp Ile Glu Glu Arg Leu Arg Gly Tyr Leu Ala Ala 
    450                 455                 460                 


Val Pro Gly Val Asp Leu Gly Ala Val Ala Ser Val Leu Ala Gly Ser 
465                 470                 475                 480 


Arg Ser Val Phe Gly His Arg Gly Val Leu Val Gly Gly Glu Leu Val 
                485                 490                 495     


Ser Gly Val Ala Leu Ser Gly Pro Arg Val Val Phe Val Phe Ser Gly 
            500                 505                 510         


Gln Gly Ser Gln Cys Val Gly Met Gly Glu Arg Leu Ala Gly Val Phe 
        515                 520                 525             


Pro Val Phe Ala Glu Val Tyr Gly Arg Val Trp Asp Leu Leu Asp Val 
    530                 535                 540                 


Pro Gly Ser Gly Leu Gly Val Asp Asp Thr Gly Phe Val Gln Pro Ala 
545                 550                 555                 560 


Leu Phe Ala Leu Gln Val Gly Leu Phe Gly Leu Leu Glu Ser Trp Gly 
                565                 570                 575     


Val Arg Pro Glu Val Val Val Gly His Ser Val Gly Glu Val Ala Ala 
            580                 585                 590         


Gly Tyr Val Ala Gly Leu Trp Ser Leu Glu Asp Ala Cys Val Leu Val 
        595                 600                 605             


Ser Ala Arg Ala Arg Leu Met Gln Gly Leu Pro Gly Gly Gly Val Met 
    610                 615                 620                 


Val Ser Val Ser Val Ser Glu Glu Arg Ala Arg Ala Ala Leu Val Glu 
625                 630                 635                 640 


Gly Val Glu Ile Ala Ala Val Asn Gly Pro Ser Ser Val Val Leu Ser 
                645                 650                 655     


Gly Asp Glu Ala Ala Val Val Gly Val Ala Glu Gly Leu Gly Gly Arg 
            660                 665                 670         


Trp Arg Arg Leu Ala Thr Ser His Ala Phe His Ser Ala Arg Met Asp 
        675                 680                 685             


Pro Met Leu Asp Glu Phe Arg Val Val Ala Glu Gly Leu Glu Tyr Arg 
    690                 695                 700                 


Glu Pro Arg Ile Val Met Ala Gly Gly Ala Gly Val Val Ser Pro Glu 
705                 710                 715                 720 


Tyr Trp Val Arg Gln Val Arg Asp Thr Val Arg Phe Gly Asp Gln Val 
                725                 730                 735     


Ala Ala Tyr Gln Gly Asp Ala Val Phe Val Glu Val Gly Pro Gly Gly 
            740                 745                 750         


Ser Leu Ala Arg Leu Ile Asp Gly Val Ala Val Gly Asp Gly Glu Asp 
        755                 760                 765             


Glu Val Arg Ala Ala Val Met Ala Val Ala Glu Leu Phe Val Arg Gly 
    770                 775                 780                 


Val Asp Val Asp Trp Pro Ala Val Val Gly Thr Thr Ala Thr Pro Val 
785                 790                 795                 800 


Asp Leu Pro Thr Tyr Pro Phe Gln Arg Gln Arg Tyr Trp Ala Trp Leu 
                805                 810                 815     


Thr Gly Leu Ala Ser Glu Asp Arg Arg Gln Ala Leu Leu Lys Val Val 
            820                 825                 830         


Arg Asp Ser Ala Ala Thr Val Leu Gly His Ala Asp Ala Arg Ala Val 
        835                 840                 845             


Glu Val Asp Arg Ala Phe Arg Asp Leu Gly Val Asp Ser Leu Thr Ala 
    850                 855                 860                 


Val Gln Val Arg Asn Asn Leu Ala Lys Ala Thr Gly Leu Arg Leu Pro 
865                 870                 875                 880 


Ala Thr Met Val Phe Asp Tyr Pro Thr Pro Ala Ala Leu Ala Ala Arg 
                885                 890                 895     


Leu Asp 
        


<210>  75
<211>  923
<212>  PRT
<213>  Streptomyces hygroscopicus

<400>  75

Glu Pro Leu Ala Ile Val Gly Met Ala Cys Arg Leu Pro Gly Gly Val 
1               5                   10                  15      


Asp Ser Pro Glu Asp Leu Trp Arg Leu Val Glu Ser Gly Thr Asp Val 
            20                  25                  30          


Ile Ser Gly Phe Pro Thr Asp Arg Gly Trp Asp Leu Asp Asn Leu Tyr 
        35                  40                  45              


Asp Pro Asp Pro Ala Val Gly Lys Ser Tyr Cys Val Gln Gly Tyr Phe 
    50                  55                  60                  


Leu Asp Asp Val Ala Asp Phe Asp Ala Ser Phe Phe Gly Ile Ser Pro 
65                  70                  75                  80  


Arg Glu Ala Leu Ala Met Asp Pro Gln Gln Arg Leu Ile Leu Glu Ala 
                85                  90                  95      


Ser Trp Glu Ala Phe Glu Arg Ala Gly Ile Glu Pro Gly Ser Val Arg 
            100                 105                 110         


Gly Ser Asp Thr Gly Val Phe Met Gly Ala Phe Ser Ser Gly Tyr Gly 
        115                 120                 125             


Ile Gly Ala Asp His Ser Gly Phe Gly Met Thr Ala Gly Ala Gly Ser 
    130                 135                 140                 


Val Leu Ser Gly Arg Val Ser Tyr Leu Phe Gly Leu Glu Gly Pro Ala 
145                 150                 155                 160 


Met Thr Val Asp Thr Ala Cys Ser Ser Ser Leu Val Ala Leu His Gln 
                165                 170                 175     


Ala Gly Ser Ala Leu Arg Gln Gly Glu Cys Ser Leu Ala Leu Val Gly 
            180                 185                 190         


Gly Ala Thr Val Met Pro Thr Pro Gln Thr Phe Val Glu Phe Ala Arg 
        195                 200                 205             


Gln Arg Gly Leu Ala Thr Asp Gly Arg Ser Lys Ala Phe Ala Asp Ala 
    210                 215                 220                 


Ala Asp Gly Ala Gly Trp Ala Glu Gly Val Gly Val Leu Val Val Glu 
225                 230                 235                 240 


Arg Leu Ser Asp Ala Gln Ala Arg Gly His Arg Val Leu Ala Val Val 
                245                 250                 255     


Arg Gly Ser Ala Val Asn Gln Asp Gly Ala Ser Asn Gly Leu Thr Ala 
            260                 265                 270         


Pro Asn Gly Pro Ser Gln Gln Arg Val Ile Arg Gln Ala Leu Ala Asn 
        275                 280                 285             


Ala Gly Leu Ser Ser Ala Asp Val Asp Val Val Glu Ala His Gly Thr 
    290                 295                 300                 


Gly Thr Arg Leu Gly Asp Pro Ile Glu Ala Gln Ala Val Ile Glu Thr 
305                 310                 315                 320 


Tyr Gly Gln Asp Arg Glu Arg Pro Leu Leu Leu Gly Ser Leu Lys Ser 
                325                 330                 335     


Asn Ile Gly His Thr Gln Ala Ala Ala Gly Val Ser Ala Val Ile Lys 
            340                 345                 350         


Met Val Met Ala Leu Arg His Gly Val Val Pro Gln Thr Leu His Val 
        355                 360                 365             


Asp Glu Pro Ser Arg His Val Asp Trp Thr Ala Gly Ala Val Gln Leu 
    370                 375                 380                 


Ala Thr Glu Lys Gln Pro Trp Pro Ala Ser Asp Arg Ala Arg Arg Ala 
385                 390                 395                 400 


Gly Val Ser Ser Phe Gly Ile Ser Gly Thr Asn Ala His Val Ile Leu 
                405                 410                 415     


Glu Ser Ala Pro Ala Gln Pro Leu Glu Thr Asp Glu Pro Ser Ala Pro 
            420                 425                 430         


Ile Val Ala Ser Asp Val Val Pro Leu Val Val Ser Ala Lys Thr Leu 
        435                 440                 445             


Asp Ala Leu Thr Asp Ile Glu Asp Arg Leu Arg Gly Tyr Leu Ala Ala 
    450                 455                 460                 


Ala Ser Asp Val Asp Met Ala Ala Val Ala Ser Thr Leu Ala Ala Thr 
465                 470                 475                 480 


Arg Ser Ile Phe Glu His Arg Ala Val Leu Leu Gly Asp Asp Thr Ile 
                485                 490                 495     


Thr Gly Ile Ala Thr Pro Gly Pro Arg Val Val Phe Val Phe Pro Gly 
            500                 505                 510         


Gln Gly Trp Gln Trp Leu Gly Met Gly Ser Thr Leu Arg Glu Thr Ser 
        515                 520                 525             


Pro Val Phe Ala Ala Arg Met Ala Glu Cys Ala Ala Ala Leu Arg Glu 
    530                 535                 540                 


Phe Val Asp Trp Asp Leu Phe Ser Ile Leu Asp Asp Pro Thr Val Val 
545                 550                 555                 560 


Asp Arg Val Asp Val Leu Gln Pro Ala Cys Trp Ala Val Met Val Ser 
                565                 570                 575     


Leu Ala Ala Val Trp Gln Glu Ala Gly Val Ser Pro Asp Ala Val Ile 
            580                 585                 590         


Gly His Ser Gln Gly Glu Ile Ala Ala Ala Cys Val Ala Gly Ala Val 
        595                 600                 605             


Ser Leu Gln Asp Ala Ala Arg Ile Val Ala Leu Arg Ser Lys Leu Ile 
    610                 615                 620                 


Ala His Leu Ala Gly His Gly Ala Met Ala Ser Ile Ala Leu Pro Ala 
625                 630                 635                 640 


Asp Ala Ile Thr Leu Thr Asp Gly Ala Trp Ile Ala Ala His Asn Gly 
                645                 650                 655     


Thr Ala Ser Thr Val Ile Ala Gly Thr Pro Gln Ala Val Asp Thr Val 
            660                 665                 670         


Leu Ala Thr His Glu Ala Gln Gly Ile Arg Val Arg Arg Ile Thr Val 
        675                 680                 685             


Asp Tyr Ala Ser His Ser Pro Gln Val Glu Glu Ile His Thr Glu Leu 
    690                 695                 700                 


Leu Asp Ala Thr Thr Thr Ile Asn Pro Arg Thr Pro Ala Val Pro Trp 
705                 710                 715                 720 


Leu Ser Thr Val Asp Asn Thr Trp Ile Ser Arg Pro Leu Asp Thr Asp 
                725                 730                 735     


Tyr Trp Tyr Arg Asn Leu Arg Glu Pro Val Arg Phe Asp Gln Ala Val 
            740                 745                 750         


Thr Leu Leu Gln Thr Arg Gly Glu Thr Val Phe Ile Glu Val Ser Ala 
        755                 760                 765             


Ser Pro Ala Leu Thr Pro Ala Met Asn Asp Asp Ala Ile Thr Val Ala 
    770                 775                 780                 


Thr Leu Arg Arg Asp Asp Asp Ser Pro Ala Arg Ile Leu Thr Ala Leu 
785                 790                 795                 800 


Ala Glu Ala Phe Val Gln Gly Val Gly Val Asp Trp Pro Ala Val Thr 
                805                 810                 815     


Gly Ala Thr Thr Ala Arg Val Leu Asp Leu Pro Thr Tyr Ala Phe Gln 
            820                 825                 830         


His Gln Arg Tyr Trp Ala Thr Ala Trp Leu Ala Gly Leu Ala Pro Ala 
        835                 840                 845             


Glu Arg Gly Glu Ala Leu Leu Lys Val Val Ser Asp Thr Val Ala Arg 
    850                 855                 860                 


Val Leu Gly His Ala Asp Gly Arg Thr Ile Pro Ala Thr Ala Ala Phe 
865                 870                 875                 880 


Lys Glu Leu Gly Val Asp Ser Leu Thr Ala Val Glu Leu Arg Asn Arg 
                885                 890                 895     


Leu Ser Ala Ala Thr Gly Leu Arg Leu Pro Ala Thr Met Val Phe Asp 
            900                 905                 910         


Tyr Pro Ser Pro Gly Ala Leu Ala Gly Trp Leu 
        915                 920             


<210>  76
<211>  930
<212>  PRT
<213>  Streptomyces hygroscopicus

<400>  76

Gln Pro Leu Ala Ile Val Gly Met Ala Cys Arg Leu Pro Gly Gly Val 
1               5                   10                  15      


Ala Ser Pro Glu Asp Leu Trp Arg Leu Val Glu Ser Gly Thr Asp Ala 
            20                  25                  30          


Ile Ser Asp Phe Pro Val Asp Arg Gly Trp Asp Leu Glu Gly Leu Tyr 
        35                  40                  45              


Asp Pro Ala Ser Asp Glu Pro Gly Val Leu Tyr Cys Asp Gln Gly Gly 
    50                  55                  60                  


Phe Leu Asp Ala Ala Ala Gly Phe Asp Ala Ala Phe Phe Gly Ile Ser 
65                  70                  75                  80  


Pro Arg Glu Ala Ala Ala Met Asp Pro Gln Gln Arg Leu Val Leu Glu 
                85                  90                  95      


Ala Ser Trp Glu Ala Phe Glu Arg Ala Gly Ile Glu Pro Gly Ser Val 
            100                 105                 110         


Arg Gly Ser Asp Thr Gly Val Phe Met Gly Ala Met Ala Asn Gly Tyr 
        115                 120                 125             


Gly Ala Gly Ala Asp Leu Gly Gly Phe Gly Ala Thr Ala Gly Ala Gly 
    130                 135                 140                 


Ser Val Leu Ser Gly Arg Ile Ser Tyr Phe Phe Gly Leu Glu Gly Pro 
145                 150                 155                 160 


Ala Met Thr Val Asp Thr Ala Cys Ser Ser Ser Leu Val Ala Leu His 
                165                 170                 175     


Gln Ala Ser Phe Ala Leu Arg Gln Gly Glu Cys Ser Leu Ala Leu Val 
            180                 185                 190         


Gly Gly Val Thr Val Met Pro Thr Pro Gln Thr Phe Val Glu Phe Ala 
        195                 200                 205             


Arg Gln Arg Gly Leu Ala Ala Asp Gly Arg Ser Lys Ala Phe Ser Asp 
    210                 215                 220                 


Ala Ala Asp Gly Ala Gly Trp Ala Glu Gly Val Gly Val Leu Val Val 
225                 230                 235                 240 


Glu Arg Leu Ser Asp Ala Gln Ala Lys Gly His Gln Val Leu Ala Val 
                245                 250                 255     


Val Arg Gly Ser Ala Val Asn Gln Asp Gly Ala Ser Asn Gly Leu Thr 
            260                 265                 270         


Ala Pro Asn Gly Pro Ser Gln Gln Arg Val Ile Arg Gln Ala Leu Ala 
        275                 280                 285             


Asn Ala Gly Leu Ser Ser Ala Glu Val Asp Val Val Glu Ala His Gly 
    290                 295                 300                 


Thr Gly Thr Arg Leu Gly Asp Pro Ile Glu Ala Gln Ala Val Ile Ala 
305                 310                 315                 320 


Thr Tyr Gly Gln Asp Arg Glu Arg Pro Leu Leu Leu Gly Ser Leu Lys 
                325                 330                 335     


Ser Asn Ile Gly His Ala Gln Ala Ala Ala Gly Val Ser Gly Val Ile 
            340                 345                 350         


Lys Met Val Met Ala Leu Arg His Gly Val Val Pro Gln Thr Leu His 
        355                 360                 365             


Val Asp Glu Pro Ser Arg His Val Asp Trp Ala Ala Gly Ala Val Glu 
    370                 375                 380                 


Leu Val Thr Glu Asn Gln Pro Trp Pro Val Ala Glu Arg Ala Arg Arg 
385                 390                 395                 400 


Ala Gly Val Ser Ser Phe Gly Ile Ser Gly Thr Asn Ala His Val Ile 
                405                 410                 415     


Leu Glu Ser Ala Pro Ala Glu Ala Ala Ser Ala Ser Glu Pro Val Thr 
            420                 425                 430         


Pro Pro Ser Glu Ala Ser Val Pro Val Val Ala Ser Asp Val Val Pro 
        435                 440                 445             


Leu Val Val Ser Ala Lys Thr Pro Gly Ala Leu Thr Asp Ile Glu Glu 
    450                 455                 460                 


Arg Leu Arg Gly Tyr Leu Ala Ala Ala Pro Glu Ala Asp Met Gln Ala 
465                 470                 475                 480 


Val Ala Ser Thr Leu Ala Ala Thr Arg Ser Val Phe Glu His Arg Ala 
                485                 490                 495     


Val Leu Leu Gly Asp Asp Thr Ile Thr Gly Val Ala Ala Ser Gly Pro 
            500                 505                 510         


Arg Val Val Phe Val Phe Pro Gly Gln Gly Trp Gln Trp Leu Gly Met 
        515                 520                 525             


Gly Ser Val Leu Arg Glu Thr Ser Pro Val Phe Ala Gly Gln Met Ala 
    530                 535                 540                 


Glu Cys Ala Ala Ala Leu Arg Glu Phe Val Asp Trp Asp Leu Phe Ser 
545                 550                 555                 560 


Val Leu Asp Asp Pro Thr Val Val Asp Arg Val Asp Val Leu Gln Pro 
                565                 570                 575     


Ala Cys Trp Ala Val Met Val Ser Leu Ala Ala Val Trp Gln Glu Ala 
            580                 585                 590         


Gly Val Ser Pro Asp Ala Val Ile Gly His Ser Gln Gly Glu Ile Ala 
        595                 600                 605             


Ala Ala Cys Val Ala Gly Ala Val Ser Leu Arg Asp Ala Ala Arg Ile 
    610                 615                 620                 


Val Ala Leu Arg Ser Lys Leu Ile Gly Ala Arg Leu Gly His Gly Ala 
625                 630                 635                 640 


Met Ala Ser Ile Ala Leu Pro Ala Gly Ala Ile Thr Leu Thr Asp Gly 
                645                 650                 655     


Ala Trp Ile Ala Ala His Asn Gly Pro Ala Ser Thr Val Ile Ala Gly 
            660                 665                 670         


Thr Pro Gln Ala Val Asp Ala Val Leu Ala Ala Tyr Glu Ala Gln Gly 
        675                 680                 685             


Ile Arg Val Arg Arg Ile Thr Val Asp Tyr Ala Ser His Ser Pro Gln 
    690                 695                 700                 


Val Glu Glu Ile Arg Ala Glu Leu Leu Asp Ala Thr Ala Thr Val Gly 
705                 710                 715                 720 


Ser Gln Ala Pro Val Val Pro Trp Leu Ser Thr Val Asp Gly Ala Trp 
                725                 730                 735     


Val Glu Gly Pro Leu Asp Ala Asp Tyr Trp Tyr Arg Asn Leu Arg Glu 
            740                 745                 750         


Pro Val Arg Phe Asp Gln Ala Val Thr Leu Leu Gln Thr Gln Gly Glu 
        755                 760                 765             


Thr Val Phe Ile Glu Val Ser Ala Ser Pro Ala Leu Thr Pro Ala Met 
    770                 775                 780                 


Asn Asp Asp Ala Ile Thr Val Ala Thr Leu Arg Arg Asp Asp Asp Ser 
785                 790                 795                 800 


Pro Ala Arg Ile Leu Thr Ala Leu Ala Glu Ala Phe Val Gln Gly Val 
                805                 810                 815     


Gly Val Asp Trp Pro Ala Ala Thr Gly Ala Thr Thr Ser Arg Val Asp 
            820                 825                 830         


Leu Pro Thr Tyr Pro Phe Gln His Gln Arg Tyr Trp Thr Gln Thr Leu 
        835                 840                 845             


Ser Gly Leu Ala Ala Ala Glu Arg Arg Gln Ala Leu Ala Lys Leu Val 
    850                 855                 860                 


Arg Glu Ser Ala Ala Val Val Leu Gly His Ala Asp Pro Asp Ser Val 
865                 870                 875                 880 


Pro Ala Ala Ala Ala Phe Lys Asp Leu Gly Val Asp Ser Leu Thr Ala 
                885                 890                 895     


Val Glu Leu Arg Asn Ser Leu Gly Arg Ser Thr Gly Leu Arg Leu Pro 
            900                 905                 910         


Ala Thr Met Val Phe Asp Tyr Pro Thr Pro Asp Ala Leu Ala Ala Arg 
        915                 920                 925             


Leu Asp 
    930 


<210>  77
<211>  930
<212>  PRT
<213>  Streptomyces hygroscopicus

<400>  77

Glu Pro Leu Ala Ile Val Gly Met Ala Cys Arg Leu Pro Gly Gly Val 
1               5                   10                  15      


Asp Ser Pro Glu Asp Leu Trp Arg Leu Val Glu Ser Gly Thr Asp Ala 
            20                  25                  30          


Ile Ser Gly Phe Pro Thr Asp Arg Gly Trp Asp Leu Asp Ser Leu Tyr 
        35                  40                  45              


Asp Pro Ile Leu Gly Ala Ser Gly Glu Phe Tyr Ser Ala Gln Gly Gly 
    50                  55                  60                  


Phe Leu Asp Arg Ala Ala Asp Phe Asp Ala Ser Phe Phe Gly Ile Ser 
65                  70                  75                  80  


Pro Arg Glu Ala Leu Ala Met Asp Pro Gln Gln Arg Leu Val Leu Glu 
                85                  90                  95      


Val Ser Trp Glu Ala Leu Glu Arg Ala Gly Ile Glu Ala Ser Ser Val 
            100                 105                 110         


Arg Gly Ser Asp Thr Gly Val Phe Met Gly Ala Phe Ser Ser Gly Tyr 
        115                 120                 125             


Gly Thr Gly Ser Asp Phe Gly Ala Phe Gly Ala Thr Ser Ser Ala Gly 
    130                 135                 140                 


Ser Val Leu Ser Gly Arg Ile Ser Tyr Phe Phe Gly Leu Glu Gly Pro 
145                 150                 155                 160 


Ala Met Thr Val Asp Thr Ala Cys Ser Ser Ser Leu Val Ala Leu His 
                165                 170                 175     


Gln Ala Gly Ser Ala Leu Arg Gln Gly Glu Cys Ser Leu Ala Leu Val 
            180                 185                 190         


Gly Gly Ile Thr Val Met Ser Thr Pro Leu Thr Phe Ala Glu Phe Ala 
        195                 200                 205             


Arg Gln Arg Gly Leu Ala Pro Asp Gly Arg Ser Lys Ala Phe Ser Asp 
    210                 215                 220                 


Ala Ala Asp Gly Ala Gly Phe Ser Glu Gly Val Gly Val Leu Val Val 
225                 230                 235                 240 


Glu Arg Leu Ser Asp Ala Gln Ala Lys Gly His Arg Val Leu Ala Val 
                245                 250                 255     


Val Arg Gly Ser Ala Val Asn Gln Asp Gly Ala Ser Asn Gly Leu Thr 
            260                 265                 270         


Ala Pro Asn Gly Pro Ser Gln Gln Arg Val Ile Arg Gln Ala Leu Ala 
        275                 280                 285             


Asn Ala Gly Leu Ala Ser Ala Asp Val Asp Val Val Glu Ala His Gly 
    290                 295                 300                 


Thr Gly Thr Arg Leu Gly Asp Pro Ile Glu Ala Gln Ala Val Ile Ala 
305                 310                 315                 320 


Thr Tyr Gly Gln Asp Arg Glu Arg Pro Leu Leu Leu Gly Ser Leu Lys 
                325                 330                 335     


Ser Asn Ile Gly His Ala Gln Ala Ala Ala Gly Val Ser Gly Val Ile 
            340                 345                 350         


Lys Met Val Met Ala Leu Arg His Gly Val Val Pro Gln Thr Leu His 
        355                 360                 365             


Val Asp Glu Pro Ser Arg His Val Asp Trp Ala Ala Gly Ala Val Glu 
    370                 375                 380                 


Leu Val Thr Glu Asn Gln Pro Trp Pro Val Ala Glu Arg Ala Arg Arg 
385                 390                 395                 400 


Ala Gly Val Ser Ser Phe Gly Ile Ser Gly Thr Asn Ala His Val Ile 
                405                 410                 415     


Leu Glu Ser Ala Pro Ala Glu Ala Ala Ser Ala Ser Glu Pro Val Thr 
            420                 425                 430         


Pro Pro Ser Glu Ala Ser Val Pro Val Val Ala Ser Asp Val Val Pro 
        435                 440                 445             


Leu Val Val Ser Ala Lys Thr Pro Gly Ala Leu Thr Asp Ile Glu Glu 
    450                 455                 460                 


Arg Leu Arg Gly Tyr Leu Ala Ala Ala Ser Asp Val Asp Met Ala Val 
465                 470                 475                 480 


Val Ala Ser Thr Leu Ala Ala Thr Arg Ser Val Phe Glu His Arg Ala 
                485                 490                 495     


Val Leu Leu Gly Asp Asp Thr Ile Thr Gly Val Ala Ala Ser Gly Pro 
            500                 505                 510         


Arg Val Val Phe Val Phe Pro Gly Gln Gly Trp Gln Trp Leu Gly Met 
        515                 520                 525             


Gly Ser Val Leu Arg Glu Thr Ser Pro Val Phe Ala Gly Arg Met Ala 
    530                 535                 540                 


Glu Cys Ala Ala Ala Leu Arg Glu Phe Val Asp Trp Asp Leu Phe Ser 
545                 550                 555                 560 


Val Leu Asp Asp Pro Thr Val Val Asp Arg Val Asp Val Leu Gln Pro 
                565                 570                 575     


Ala Cys Trp Ala Val Met Val Ser Leu Ala Ala Val Trp Gln Glu Ala 
            580                 585                 590         


Gly Val Ser Pro Asp Ala Val Ile Gly His Ser Gln Gly Glu Ile Ala 
        595                 600                 605             


Ala Ala Cys Val Ala Gly Ala Val Ser Leu Arg Asp Ala Ala Arg Ile 
    610                 615                 620                 


Val Ala Leu Arg Ser Lys Leu Ile Gly Ala Arg Leu Gly His Gly Ala 
625                 630                 635                 640 


Met Ala Ser Ile Ala Leu Pro Ala Asp Ala Ile Thr Leu Thr Asp Gly 
                645                 650                 655     


Ala Trp Ile Ala Ala His Asn Gly Pro Ala Ser Thr Val Ile Ala Gly 
            660                 665                 670         


Thr Pro Gln Ala Val Asp Ala Val Leu Ala Ala Tyr Glu Ala Gln Gly 
        675                 680                 685             


Ile Arg Val Arg Arg Ile Thr Val Asp Tyr Ala Ser His Ser Pro Gln 
    690                 695                 700                 


Val Glu Glu Ile Arg Ala Glu Leu Leu Asp Ala Thr Ala Thr Val Gly 
705                 710                 715                 720 


Ser Gln Ala Pro Val Val Pro Trp Leu Ser Thr Val Asp Asn Thr Trp 
                725                 730                 735     


Ile Ser Arg Pro Leu Asp Thr Asp Tyr Trp Tyr Arg Asn Leu Arg Glu 
            740                 745                 750         


Pro Val Arg Phe Asp Gln Ala Val Thr Leu Leu Gln Thr Gln Gly Glu 
        755                 760                 765             


Thr Val Phe Ile Glu Val Ser Ala Ser Pro Ala Leu Thr Pro Ala Met 
    770                 775                 780                 


Asn Asp Asp Ala Ile Thr Val Ala Thr Leu Arg Arg Asp Asp Asp Ser 
785                 790                 795                 800 


Pro Ala Arg Ile Leu Thr Ala Leu Ala Glu Ala Phe Val Gln Gly Val 
                805                 810                 815     


Gly Val Asp Trp Pro Ala Val Thr Gly Ala Thr Thr Ala Arg Val Leu 
            820                 825                 830         


Asp Leu Pro Thr Tyr Pro Phe Gln Arg Gln Arg Tyr Trp Ala Trp Leu 
        835                 840                 845             


Thr Gly Leu Ala Ser Glu Asp Arg Arg Gln Ala Leu Leu Lys Val Val 
    850                 855                 860                 


Arg Asp Ser Ala Ala Thr Val Leu Gly His Ala Asp Ala Arg Ala Val 
865                 870                 875                 880 


Glu Val Asp Arg Ala Phe Arg Asp Leu Gly Val Asp Ser Leu Thr Ala 
                885                 890                 895     


Val Gln Val Arg Asn Asn Leu Ala Lys Ala Thr Gly Leu Arg Leu Pro 
            900                 905                 910         


Ala Thr Met Val Phe Asp Tyr Pro Thr Pro Ala Ala Leu Ala Ala Arg 
        915                 920                 925             


Leu Asp 
    930 


<210>  78
<211>  923
<212>  PRT
<213>  Streptomyces hygroscopicus

<400>  78

Glu Pro Leu Ala Ile Val Gly Met Ala Cys Arg Leu Pro Gly Gly Val 
1               5                   10                  15      


Ala Ser Pro Glu Asp Leu Trp Arg Leu Val Glu Ser Gly Thr Asp Val 
            20                  25                  30          


Ile Ser Gly Phe Pro Thr Asp Arg Gly Trp Asp Leu Asp Asn Leu Tyr 
        35                  40                  45              


Asp Pro Asp Pro Ala Val Gly Lys Ser Tyr Cys Val Gln Gly Tyr Phe 
    50                  55                  60                  


Leu Asp Asp Val Ala Asp Phe Asp Ala Ser Phe Phe Gly Ile Ser Pro 
65                  70                  75                  80  


Arg Glu Ala Leu Ala Met Asp Pro Gln Gln Arg Leu Ile Leu Glu Ala 
                85                  90                  95      


Ser Trp Glu Ala Phe Glu Arg Ala Gly Ile Glu Pro Gly Ser Val Arg 
            100                 105                 110         


Gly Ser Asp Thr Gly Val Phe Met Gly Ala Phe Ser Ser Gly Tyr Gly 
        115                 120                 125             


Ile Gly Ala Asp His Ser Gly Phe Gly Met Thr Ala Gly Ala Gly Ser 
    130                 135                 140                 


Val Leu Ser Gly Arg Ile Ser Tyr Leu Phe Gly Leu Glu Gly Pro Ala 
145                 150                 155                 160 


Met Thr Val Asp Thr Ala Cys Ser Ser Ser Leu Val Ala Leu His Gln 
                165                 170                 175     


Ala Ser Ser Ala Leu Arg Gln Gly Glu Cys Ser Leu Ala Leu Val Gly 
            180                 185                 190         


Gly Ala Thr Val Leu Ala Thr Pro Tyr Gly Phe Val Glu Ile Ser Arg 
        195                 200                 205             


Gln Arg Gly Leu Ala Ala Asp Gly Arg Ser Lys Ala Phe Ser Asp Ala 
    210                 215                 220                 


Ala Asp Gly Met Ser Phe Ser Glu Gly Ala Gly Val Leu Val Leu Glu 
225                 230                 235                 240 


Arg Leu Ser Asp Ala Gln Ala Lys Gly His Arg Val Leu Ala Val Val 
                245                 250                 255     


Arg Gly Ser Ala Val Asn Gln Asp Gly Ala Ser Asn Gly Leu Thr Ala 
            260                 265                 270         


Pro Asn Gly Pro Ser Gln Gln Arg Val Ile Gln Gln Ala Leu Ala Asn 
        275                 280                 285             


Ala Gly Leu Ala Ser Ala Asp Val Asp Val Val Glu Ala His Gly Thr 
    290                 295                 300                 


Gly Thr Arg Leu Gly Asp Pro Ile Glu Ala Gln Ala Val Ile Ala Thr 
305                 310                 315                 320 


Tyr Gly Gln Asn Arg Glu Arg Pro Val Leu Leu Gly Ser Leu Lys Ser 
                325                 330                 335     


Asn Ile Gly His Thr His Ala Ala Ala Gly Val Ser Gly Val Ile Lys 
            340                 345                 350         


Met Val Met Ala Leu Gln His Gly Val Val Pro Arg Thr Leu His Val 
        355                 360                 365             


Asp Ala Pro Ser Arg His Val Asp Trp Ala Ala Gly Ala Val Glu Leu 
    370                 375                 380                 


Val Thr Glu Asn Gln Pro Trp Pro Val Ala Glu Arg Ala Arg Arg Ala 
385                 390                 395                 400 


Gly Val Ser Ser Phe Gly Ile Ser Gly Thr Asn Ala His Val Ile Leu 
                405                 410                 415     


Glu Ser Ala Pro Ala Gln Pro Leu Glu Thr Gly Glu Pro Ser Ala Pro 
            420                 425                 430         


Ile Val Ala Ser Asp Val Val Pro Leu Val Val Ser Ala Lys Thr Pro 
        435                 440                 445             


Asp Ala Leu Thr Asp Ile Glu Asp Arg Leu Arg Ala His Leu Ala Ala 
    450                 455                 460                 


Ala Pro Glu Ala Asp Met Gln Ala Val Ala Ser Thr Leu Ala Ala Thr 
465                 470                 475                 480 


Arg Ser Ile Phe Glu His Arg Ala Val Leu Leu Gly Asp Asp Thr Ile 
                485                 490                 495     


Thr Gly Ile Ala Thr Pro Asp Pro Arg Val Val Phe Val Phe Pro Gly 
            500                 505                 510         


Gln Gly Trp Gln Trp Leu Gly Met Gly Ser Thr Leu Arg Glu Thr Ser 
        515                 520                 525             


Pro Val Phe Ala Ala Arg Met Ala Glu Cys Ala Thr Ala Leu Arg Glu 
    530                 535                 540                 


Phe Val Asp Trp Asp Leu Phe Ser Ile Leu Asp Asp Pro Thr Val Val 
545                 550                 555                 560 


Asp Arg Val Asp Val Leu Gln Pro Ala Cys Trp Ala Val Met Val Ser 
                565                 570                 575     


Leu Ala Ala Val Trp Gln Glu Ala Gly Val Ser Pro Asp Ala Val Ile 
            580                 585                 590         


Gly His Ser Gln Gly Glu Ile Ala Ala Ala Cys Val Ala Gly Ala Val 
        595                 600                 605             


Ser Leu Gln Asp Ala Ala Arg Ile Val Ala Leu Arg Ser Lys Leu Ile 
    610                 615                 620                 


Ala His Leu Ala Gly His Gly Ala Met Ala Ser Ile Ala Leu Pro Ala 
625                 630                 635                 640 


Asp Ala Ile Thr Leu Thr Asp Gly Ala Trp Ile Ala Ala His Asn Gly 
                645                 650                 655     


Pro Ala Ser Thr Val Ile Ala Gly Thr Pro Gln Ala Val Asp Thr Val 
            660                 665                 670         


Leu Ala Thr His Glu Ala Gln Gly Ile Arg Val Arg Arg Ile Thr Val 
        675                 680                 685             


Asp Tyr Ala Ser His Ser Pro Gln Val Glu Glu Ile Arg Ala Glu Leu 
    690                 695                 700                 


Leu Asp Ala Thr Ala Thr Val Gly Ser Gln Ala Pro Val Val Pro Trp 
705                 710                 715                 720 


Leu Ser Thr Val Asp Gly Ala Trp Val Glu Gly Pro Leu Asp Ala Asp 
                725                 730                 735     


Tyr Trp Tyr Arg Asn Leu Arg Glu Pro Val Arg Phe Asp Gln Ala Val 
            740                 745                 750         


Thr Leu Leu Gln Thr Gln Gly Glu Thr Val Phe Ile Glu Val Ser Ala 
        755                 760                 765             


Ser Pro Ala Leu Thr Pro Ala Met Asn Asp Asp Ala Val Thr Val Ala 
    770                 775                 780                 


Thr Leu Arg Arg Asp Asp Asp Ser Pro Thr Arg Ile Leu Thr Ala Leu 
785                 790                 795                 800 


Ala Glu Ala Phe Val Gln Gly Val Gly Val Asp Trp Pro Ala Val Thr 
                805                 810                 815     


Gly Ala Thr Thr Thr Pro Val Asp Leu Pro Thr Tyr Pro Phe Gln Arg 
            820                 825                 830         


Gln Arg Tyr Trp Thr Ala Ser Asp Arg Leu Ser Gly Arg Thr Ser Gly 
        835                 840                 845             


Asp Gln His Arg Ile Met Leu Glu Leu Val Leu Gly His Ala Ala Ser 
    850                 855                 860                 


Val Leu Gly His Gly Ala Ala Asp Ala Val Ala Ala Asp Lys Pro Phe 
865                 870                 875                 880 


Lys Asp Leu Gly Met Asp Ser Leu Thr Ala Ile Glu Leu Arg Asn His 
                885                 890                 895     


Leu Val Ala Glu Thr Gly Leu Arg Leu Pro Ala Thr Thr Ala Phe Asp 
            900                 905                 910         


His Pro Thr Ala Asp Asp Leu Ala Arg Arg Leu 
        915                 920             


<210>  79
<211>  965
<212>  PRT
<213>  Streptomyces hygroscopicus

<400>  79

Glu Pro Ile Ala Ile Val Ser Met Ala Cys Arg Ala Pro Gly Gly Val 
1               5                   10                  15      


Asp Ser Pro Asp Gly Leu Trp Arg Leu Val Glu Ser Gly Thr Asp Ala 
            20                  25                  30          


Ile Ser Gly Phe Pro Thr Asp Arg Gly Trp Asp Val Ala Asp Leu Tyr 
        35                  40                  45              


Ser Pro Asp Pro Ala Gly Tyr Lys Ser Tyr Cys Val Gln Gly Gly Phe 
    50                  55                  60                  


Leu Asp Thr Ala Ala Asp Phe Asp Ala Ala Phe Phe Gly Ile Ser Pro 
65                  70                  75                  80  


Arg Glu Ala Leu Gly Met Asp Pro Gln Gln Arg Leu Leu Leu Glu Ala 
                85                  90                  95      


Ser Trp Glu Ala Ile Glu Arg Ala Arg Ile Asp Pro Arg Ser Leu Arg 
            100                 105                 110         


Gly Arg Ser Val Gly Val Phe Val Gly Gly Ala Ser Gln Gly Tyr Gly 
        115                 120                 125             


Ala Gly Ala Asp Asp Gln Gln Gln Ser Asn Ala Ile Thr Gly Gly Ser 
    130                 135                 140                 


Ile Ser Leu Leu Ser Gly Arg Val Ser Tyr Ala Leu Gly Leu Glu Gly 
145                 150                 155                 160 


Pro Gly Val Thr Val Asp Thr Ala Cys Ser Ser Ser Leu Val Ala Leu 
                165                 170                 175     


His Leu Ala Ser Gln Ala Leu Arg Gln Arg Glu Cys Ser Leu Ala Leu 
            180                 185                 190         


Val Ser Gly Val Ser Val Met Ala Thr Pro Asp Val Phe Val Glu Phe 
        195                 200                 205             


Ser Arg Gln Arg Gly Leu Ala Pro Asp Gly Arg Cys Lys Ser Phe Ser 
    210                 215                 220                 


Ala Ala Ala Asp Gly Thr Gly Trp Ser Glu Gly Val Gly Val Leu Val 
225                 230                 235                 240 


Leu Glu Arg Leu Ser Glu Ala Thr Arg Leu Gly His Arg Val His Ala 
                245                 250                 255     


Val Val Arg Gly Ser Ala Val Asn Ser Asp Gly Ala Ser Asn Gly Leu 
            260                 265                 270         


Thr Ala Pro Asn Gly Ala Ser Gln Gln Lys Val Ile Arg Gln Ala Leu 
        275                 280                 285             


Ala Asn Ala Gly Leu Ala Ala Ser Glu Val Asp Ala Val Glu Ala His 
    290                 295                 300                 


Gly Thr Gly Thr Lys Leu Gly Asp Pro Ile Glu Ala Glu Ala Ile Leu 
305                 310                 315                 320 


Ala Thr Tyr Gly Gln Asp Arg Ala Ala Pro Val Trp Leu Gly Ser Leu 
                325                 330                 335     


Lys Ser Asn Ile Gly His Thr Met Ala Ala Ser Gly Val Leu Gly Val 
            340                 345                 350         


Ile Lys Met Val Glu Ser Met Arg His Gly Leu Leu Pro Arg Thr Leu 
        355                 360                 365             


Asn Val Asp Glu Pro Ser Pro His Val Asp Trp Ala Ser Gly Asp Val 
    370                 375                 380                 


Ala Leu Leu Thr Glu Asn Gln Pro Trp Pro Ala Asp Val Gly Pro Arg 
385                 390                 395                 400 


Arg Ala Ala Val Ser Ser Phe Gly Ile Ser Gly Ser Asn Ala His Val 
                405                 410                 415     


Val Leu Glu Gln Tyr Gly Glu Pro Ala Gly Pro Asp Leu Ser Asp Leu 
            420                 425                 430         


Thr Asn Thr Arg Ala Val Asn Ala Ala Asp Ala Pro Asp Arg Arg Gln 
        435                 440                 445             


Pro Val Pro Leu Met Leu Ser Ala Arg Ser Gln Arg Ala Leu Arg Glu 
    450                 455                 460                 


Gln Ala Gly Arg Leu His Ala Ala Leu Ala Gly Ala Pro Asp Trp Arg 
465                 470                 475                 480 


Pro Leu Asp Ile Gly Tyr Ser Leu Ala Thr Thr Arg Ser His Phe Thr 
                485                 490                 495     


His Arg Ala Val Ala Val Gly Ser Gly Arg Glu Leu Leu Arg Ala Leu 
            500                 505                 510         


Ser Lys Leu Ala Asp Gly Ala Asp Trp Pro Ala Leu Thr Thr Arg Ile 
        515                 520                 525             


Ala Lys Ser Arg Arg Val Ala Phe Leu Phe Asp Gly Gln Gly Thr Gln 
    530                 535                 540                 


Arg Leu Gly Met Gly Ser Gly Leu Tyr Ala Gly Phe Pro Val Phe Ala 
545                 550                 555                 560 


Gly Val Trp Asp Gln Val Ser Ala Ala Phe Asp Lys His Leu Asp His 
                565                 570                 575     


Ser Leu Thr Asp Val Phe Leu Gly Arg Asp Asp Arg Pro Ala Ala Ala 
            580                 585                 590         


Glu Leu Val Asp Asp Thr Leu Tyr Ala Gln Ala Gly Leu Phe Thr Leu 
        595                 600                 605             


Glu Val Ala Leu Phe Arg Leu Leu Glu Glu Trp Gly Val Arg Pro Asp 
    610                 615                 620                 


Phe Leu Ala Gly His Ser Ile Gly Glu Ala Ala Ala Ala Tyr Ala Gly 
625                 630                 635                 640 


Gly Met Phe Ser Leu Glu Asp Val Thr Ala Leu Ile Val Ala Arg Gly 
                645                 650                 655     


Glu Ala Leu Arg Leu Ala Pro Pro Gly Ala Met Leu Ala Leu Arg Ala 
            660                 665                 670         


Ser Glu Glu Glu Val Arg Glu Phe Leu Gly Arg Thr Gly Ala Glu Leu 
        675                 680                 685             


Asp Leu Ala Ala Val Asn Gly Pro Ala Ser Val Val Val Ser Gly Ala 
    690                 695                 700                 


Ser Glu Ala Val Ala Asp Phe Arg Ala Arg Trp Thr Ala Ala Gly Arg 
705                 710                 715                 720 


Lys Ala Arg Glu Leu Asn Val Ser Arg Ala Phe His Ser Arg His Val 
                725                 730                 735     


Glu Ala Gly Leu Gly Arg Phe Arg Glu Val Leu Glu Ser Leu Thr Phe 
            740                 745                 750         


Gly Thr Pro Val Leu Pro Ile Val Ser Thr Val Thr Gly Gln Leu Val 
        755                 760                 765             


Asp Pro Val Glu Met Ser Thr Pro Glu Tyr Trp Leu Arg Gln Val Arg 
    770                 775                 780                 


Gln Pro Val Leu Phe Gln Asp Ala Leu Arg Glu Leu Ser Gly Gln Gly 
785                 790                 795                 800 


Val Asn Thr Phe Val Glu Ile Gly Pro Ser Gly Thr Leu Ala Ser Ala 
                805                 810                 815     


Gly Leu Glu Cys Leu Gly Gly Asp Ala Ser Phe His Ala Val Gln Gln 
            820                 825                 830         


Pro Arg Ser Pro Gln Asp Val Gly Leu Met Thr Ala Val Ala Glu Leu 
        835                 840                 845             


His Ala Gly Gly Thr Ala Val Asp Trp Ala Lys Ala Leu Ala Gly Gly 
    850                 855                 860                 


Arg Ala Thr Asp Leu Pro Val Tyr Pro Phe Gln His Glu Ser Tyr Trp 
865                 870                 875                 880 


Leu Ala Pro Ala Asp Tyr Ala Tyr Pro Glu Glu Pro Gly Thr Met Leu 
                885                 890                 895     


Glu Leu Val Arg Leu Glu Ala Ala Lys Val Leu Gly Ile Thr Glu Pro 
            900                 905                 910         


Asp Thr Ile Leu Glu Glu Thr Ser Phe Leu Asp Leu Gly Phe Asp Ser 
        915                 920                 925             


Leu Gly Thr Met Arg Leu Arg Asn Arg Leu Ser Glu Val Thr Glu Leu 
    930                 935                 940                 


Asp Leu Pro Ala Thr Leu Leu Phe Asp Asn Pro Ser Pro Ala Glu Leu 
945                 950                 955                 960 


Ala Ala Tyr Leu Asp 
                965 


<210>  80
<211>  908
<212>  PRT
<213>  Streptomyces filamentosus

<400>  80

Glu Pro Leu Ala Ile Val Gly Met Ala Cys Arg Leu Pro Gly Gly Val 
1               5                   10                  15      


Ser Ser Pro Glu Asp Leu Trp Arg Leu Val Glu Ser Gly Thr Asp Ala 
            20                  25                  30          


Ile Ser His Phe Pro Thr Asp Arg Gly Trp Asp Leu Asp Asn Leu Tyr 
        35                  40                  45              


Asp Pro Asp Pro Asp Ala Pro Gly Lys Gly Tyr Arg Val Gln Gly Gly 
    50                  55                  60                  


Phe Leu Asp Ala Ala Gly Phe Asp Ala Ala Phe Phe Gly Ile Ser Pro 
65                  70                  75                  80  


Arg Glu Ala Gln Ala Met Asp Pro Gln Gln Arg Leu Val Leu Glu Ala 
                85                  90                  95      


Ser Trp Glu Ala Phe Glu Arg Ala Gly Ile Asp Pro Gly Ala Met Arg 
            100                 105                 110         


Gly Ser His Thr Gly Val Phe Met Gly Ala Met Ala Asn Gly Tyr Gly 
        115                 120                 125             


Ala Gly Ala Asp Leu Gly Gly Phe Gly Ala Thr Ala Gly Ala Val Ser 
    130                 135                 140                 


Val Leu Ser Gly Arg Val Ser Tyr Leu Phe Gly Leu Glu Gly Pro Ala 
145                 150                 155                 160 


Met Thr Val Asp Thr Ala Cys Ser Ser Ser Leu Val Ala Leu His Gln 
                165                 170                 175     


Ala Ala Tyr Ser Leu Arg Gln Gly Glu Cys Ser Leu Ala Leu Val Gly 
            180                 185                 190         


Gly Val Thr Val Met Pro Thr Pro Gln Met Phe Val Glu Phe Ala Arg 
        195                 200                 205             


Gln Arg Gly Leu Ala Ala Asp Gly Arg Ser Lys Ala Phe Ala Asp Ala 
    210                 215                 220                 


Ala Asp Gly Ala Gly Phe Ser Glu Gly Val Gly Val Leu Val Val Glu 
225                 230                 235                 240 


Arg Leu Ser Asp Ala Gln Ala Lys Gly His Arg Val Leu Ala Val Val 
                245                 250                 255     


Arg Gly Ser Ala Val Asn Gln Asp Gly Ala Ser Asn Gly Leu Ser Ala 
            260                 265                 270         


Pro Asn Gly Pro Ser Gln Gln Arg Val Ile Arg Gln Ala Leu Ala Asn 
        275                 280                 285             


Ala Arg Leu Ala Pro Asn Glu Ile Asp Val Val Glu Ala His Gly Thr 
    290                 295                 300                 


Gly Thr Thr Leu Gly Asp Pro Ile Glu Ala Gln Ala Leu Ile Ala Ala 
305                 310                 315                 320 


Tyr Gly Gln Asp Arg Glu Gln Pro Val Leu Leu Gly Ser Leu Lys Ser 
                325                 330                 335     


Asn Ile Gly His Thr Gln Ala Ala Ala Gly Val Ser Gly Val Ile Lys 
            340                 345                 350         


Met Val Met Ala Leu Gln His Gly Val Val Pro Arg Thr Leu His Val 
        355                 360                 365             


Asp Ser Pro Ser Arg His Val Asp Trp Thr Ala Gly Ala Val Glu Leu 
    370                 375                 380                 


Val Thr Glu Asn Gln Pro Trp Pro Ala Ile Asp Arg Ala Arg Arg Ala 
385                 390                 395                 400 


Gly Val Ser Ser Phe Gly Ile Ser Gly Thr Asn Ala His Val Ile Leu 
                405                 410                 415     


Glu Ser Ala Pro Ala Gln Pro Val Val Glu Thr Glu Glu Val Pro Ala 
            420                 425                 430         


Pro Pro Val Val Ala Ser Asp Met Met Pro Leu Val Ile Ser Ala Lys 
        435                 440                 445             


Thr Pro Ser Ala Leu Val Glu Phe Glu Gly Arg Leu Arg Ala Tyr Leu 
    450                 455                 460                 


Thr Ser Thr Pro Gly Val Asp Met Arg Ala Val Ala Ser Thr Leu Ala 
465                 470                 475                 480 


Gly Thr Arg Ser Val Phe Glu His Arg Ala Val Leu Leu Gly Asp Glu 
                485                 490                 495     


Thr Val Thr Gly Pro Gly Thr Gly Ala Gly Ser Gly Val Ala Val Ser 
            500                 505                 510         


Asp Pro Arg Val Val Phe Val Phe Pro Gly Gln Gly Ser Gln Arg Ala 
        515                 520                 525             


Gly Met Gly Glu Gln Leu Ala Ala Val Phe Pro Val Phe Ala Glu Ile 
    530                 535                 540                 


His Gln Gln Val Trp Asp Leu Leu Asp Val Pro Asp Pro Gly Leu Asp 
545                 550                 555                 560 


Thr Asp Glu Thr Gly Tyr Ala Gln Pro Ser Leu Phe Ala Leu Gln Val 
                565                 570                 575     


Ala Leu Phe Gly Leu Leu Glu Ser Trp Gly Val Arg Pro Gln Ala Val 
            580                 585                 590         


Ile Gly His Ser Val Gly Glu Ile Ala Ala Gly Tyr Val Ala Gly Leu 
        595                 600                 605             


Trp Ser Leu Arg Asp Ala Cys Thr Leu Val Ser Ala Arg Ala Arg Leu 
    610                 615                 620                 


Met Gln Thr Leu Pro Thr Gly Gly Ala Met Val Ala Val Pro Val Ser 
625                 630                 635                 640 


Glu Lys Gln Ala Gln Ala Ala Leu Thr Asp Gly Val Glu Ile Ala Ala 
                645                 650                 655     


Val Asn Gly Pro Ser Ser Val Val Leu Thr Gly Asp Glu Thr Ala Val 
            660                 665                 670         


Leu Glu Thr Ala Ala Ala Leu Gly Arg Ser Thr Arg Leu Thr Thr Ser 
        675                 680                 685             


His Ala Phe His Ser Ala Arg Met Glu Pro Val Leu Asp Glu Phe Arg 
    690                 695                 700                 


Thr Val Ala Glu Thr Leu Asp Tyr Arg Thr Pro His Ile Pro Met Ala 
705                 710                 715                 720 


Ala Gly Asp Ala Val Val Thr Pro Glu Tyr Trp Val Arg Gln Ile Arg 
                725                 730                 735     


Asp Thr Val Arg Phe Gly Asp Gln Val Ala Ala His Glu Asn Ala Val 
            740                 745                 750         


Phe Val Glu Ile Gly Pro Asp Arg Thr Leu Ser Arg Leu Thr Asp Gly 
        755                 760                 765             


Ile Ala Met Leu His Gly Asp Asn Glu Thr Gln Thr Ala Ile Thr Ala 
    770                 775                 780                 


Leu Ala Thr Leu His Thr His Gly Val Asn Ile His Trp Pro Ala Val 
785                 790                 795                 800 


Ile Gly Ala Thr Thr Ala Arg Val Leu Asp Met Pro Thr Tyr Ala Phe 
                805                 810                 815     


Gln His Gln Arg Tyr Trp Thr Thr Trp Leu Ala Gly Leu Ala Pro Glu 
            820                 825                 830         


Glu Arg Lys Gln Ala Leu Leu Lys Val Val Arg Asp Ser Ala Ala Ala 
        835                 840                 845             


Val Leu Gly His Ala Gly Ala Asp Thr Val Pro Val Thr Ala Ala Phe 
    850                 855                 860                 


Lys Asp Leu Gly Leu Asp Ser Leu Thr Ala Val Glu Leu Arg Asn Ser 
865                 870                 875                 880 


Leu Gly Lys Ser Thr Gly Leu Arg Leu Pro Ala Thr Met Val Phe Asp 
                885                 890                 895     


Tyr Pro Asn Pro Thr Thr Leu Ala Ala Arg Leu Asp 
            900                 905             


<210>  81
<211>  902
<212>  PRT
<213>  Streptomyces filamentosus

<400>  81

Glu Pro Leu Ala Ile Val Gly Met Ala Cys Arg Leu Pro Gly Gly Val 
1               5                   10                  15      


Ser Ser Pro Glu Asp Leu Trp Arg Leu Val Glu Ser Gly Thr Asp Ala 
            20                  25                  30          


Ile Ser Gly Phe Pro Thr Asp Arg Gly Trp Asp Ile Glu Asn Leu Tyr 
        35                  40                  45              


Asp Pro Asp Pro Asp Ala Pro Gly Lys Gly Tyr Arg Val Gln Gly Gly 
    50                  55                  60                  


Phe Leu Asp Arg Ala Ala Glu Phe Asp Ala Ser Phe Phe Gly Ile Ser 
65                  70                  75                  80  


Pro Arg Glu Ala Gln Ala Met Asp Pro Gln Gln Arg Leu Val Leu Glu 
                85                  90                  95      


Thr Ser Trp Glu Ala Phe Glu Arg Ala Gly Ile Glu Pro Gly Ala Met 
            100                 105                 110         


Arg Gly Ser Asp Thr Gly Val Phe Met Gly Ala Met Ala Asn Gly Tyr 
        115                 120                 125             


Gly Thr Gly Ala Asp Leu Gly Ala Phe Gly Met Thr Ser Ala Ala Val 
    130                 135                 140                 


Ser Val Leu Ser Gly Arg Val Ser Tyr Leu Phe Gly Leu Glu Gly Pro 
145                 150                 155                 160 


Ala Met Thr Val Asp Thr Ala Cys Ser Ser Ser Leu Val Ala Leu His 
                165                 170                 175     


Gln Ala Ala Tyr Ser Leu Arg Gln Gly Glu Cys Ser Leu Ala Leu Val 
            180                 185                 190         


Gly Gly Val Thr Val Met Pro Thr Pro Gln Thr Phe Val Glu Phe Ala 
        195                 200                 205             


Arg Gln Arg Gly Leu Ala Ala Asp Gly Arg Ser Lys Ala Phe Ser Asp 
    210                 215                 220                 


Ala Ala Asp Gly Ala Gly Phe Ser Glu Gly Val Gly Val Leu Val Val 
225                 230                 235                 240 


Glu Arg Leu Ser Asp Ala Arg Ala Lys Gly His His Val Leu Ala Val 
                245                 250                 255     


Val Arg Gly Ser Ala Val Asn Gln Asp Gly Ala Ser Asn Gly Leu Ser 
            260                 265                 270         


Ala Pro Asn Gly Pro Ser Gln Gln Arg Val Ile Arg Gln Ala Leu Asp 
        275                 280                 285             


Asn Ala Gly Leu Ser Ser Thr Asp Val Asp Val Val Glu Ala His Gly 
    290                 295                 300                 


Thr Gly Thr Thr Leu Gly Asp Pro Ile Glu Ala Gln Ala Leu Ile Ala 
305                 310                 315                 320 


Ala Tyr Gly Gln Asp Arg Glu Gln Pro Val Leu Leu Gly Ser Leu Lys 
                325                 330                 335     


Ser Asn Ile Gly His Thr Gln Ala Ala Ala Gly Val Ser Gly Val Ile 
            340                 345                 350         


Lys Met Val Met Ala Leu Gln His Gly Val Val Pro Arg Thr Leu His 
        355                 360                 365             


Val Asp Ser Pro Ser Arg His Val Asp Trp Thr Ala Gly Ala Val Glu 
    370                 375                 380                 


Leu Val Thr Glu Asn Gln Pro Trp Pro Ala Ile Asp Arg Ala Arg Arg 
385                 390                 395                 400 


Ala Gly Val Ser Ser Phe Gly Ile Ser Gly Thr Asn Ala His Val Ile 
                405                 410                 415     


Leu Glu Ser Ala Pro Asp Leu Pro Val Val Glu Thr Glu Glu Thr Pro 
            420                 425                 430         


Ala Pro Val Val Thr Ser Asp Met Met Pro Leu Val Ile Ser Ala Lys 
        435                 440                 445             


Thr Pro Ala Ala Leu Ala Asp Met Glu Gly Arg Leu Arg Ser Tyr Leu 
    450                 455                 460                 


Thr Ser Met Pro Gly Val Asp Met Arg Ala Val Ala Ser Thr Leu Ala 
465                 470                 475                 480 


Gly Thr Arg Ser Val Phe Glu His Arg Ala Val Leu Leu Gly Asp Glu 
                485                 490                 495     


Thr Val Thr Gly Pro Gly Thr Gly Val Ala Val Ser Gly Pro Arg Val 
            500                 505                 510         


Val Phe Val Phe Pro Gly Gln Gly Ser Gln Arg Ala Gly Met Gly Glu 
        515                 520                 525             


Gln Leu Ala Ala Val Phe Pro Val Phe Ala Glu Ile His Gln Gln Val 
    530                 535                 540                 


Trp Asp Leu Leu Asp Val Pro Asp Pro Gly Leu Gly Ala Asp Glu Thr 
545                 550                 555                 560 


Gly Phe Ala Gln Pro Ser Leu Phe Ala Leu Gln Val Ala Leu Phe Gly 
                565                 570                 575     


Leu Leu Glu Ser Trp Gly Val Arg Pro Gln Ala Val Ile Gly His Ser 
            580                 585                 590         


Val Gly Glu Ile Ala Ala Gly Tyr Val Ala Gly Leu Trp Ser Leu Arg 
        595                 600                 605             


Asp Ala Cys Thr Leu Val Ser Ala Arg Ala Arg Leu Met Gln Thr Leu 
    610                 615                 620                 


Pro Thr Gly Gly Ala Met Val Ala Val Pro Val Ser Glu Lys Gln Ala 
625                 630                 635                 640 


Gln Ala Ala Leu Thr Asp Gly Val Glu Ile Ala Ala Val Asn Gly Pro 
                645                 650                 655     


Ser Ser Val Val Leu Thr Gly Asp Glu Thr Ala Val Leu Glu Thr Ala 
            660                 665                 670         


Ala Ala Leu Gly Lys Ser Thr Arg Leu Thr Thr Ser His Ala Phe His 
        675                 680                 685             


Ser Ala Arg Met Glu Pro Val Leu Asp Gln Phe Arg Thr Val Ala Glu 
    690                 695                 700                 


Thr Leu Asp Tyr Arg Thr Pro His Ile Pro Met Ala Ala Gly Asp Ala 
705                 710                 715                 720 


Val Val Thr Pro Glu Tyr Trp Val Arg Gln Ile Arg Asp Thr Val Arg 
                725                 730                 735     


Phe Gly Asp Gln Val Ala Ala His Glu Asn Ala Val Phe Val Glu Ile 
            740                 745                 750         


Gly Pro Asp Arg Thr Leu Ser Arg Leu Thr Asp Gly Ile Ala Met Leu 
        755                 760                 765             


His Gly Asp Asn Glu Thr Gln Thr Ala Ile Thr Ala Leu Ala Thr Leu 
    770                 775                 780                 


His Thr His Gly Val Asn Ile His Trp Pro Ala Val Ile Gly Ala Thr 
785                 790                 795                 800 


Thr Thr Pro Val Asp Leu Pro Thr Tyr Ala Phe Glu Arg Gln Arg Tyr 
                805                 810                 815     


Trp Ala Trp Leu Ala Gly Leu Ala Pro Glu Glu Arg Lys Gln Ala Leu 
            820                 825                 830         


Leu Lys Thr Val Arg Asp Asn Ala Ala Lys Val Leu Gly His Ala Asp 
        835                 840                 845             


Ala Arg Asp Ile Ala Val Asn Thr Ala Phe Arg Asp Leu Gly Leu Asp 
    850                 855                 860                 


Ser Leu Thr Ala Val Gln Val Arg Asn Ser Leu Ala Lys Ala Thr Gly 
865                 870                 875                 880 


Leu Arg Leu Pro Thr Thr Thr Val Phe Asp Tyr Pro Asn Pro Thr Ala 
                885                 890                 895     


Leu Ala Thr His Leu Asp 
            900         


<210>  82
<211>  901
<212>  PRT
<213>  Streptomyces filamentosus

<400>  82

Glu Pro Leu Ala Ile Val Gly Met Ala Cys Arg Leu Pro Gly Gly Val 
1               5                   10                  15      


Ser Ser Pro Glu Asp Leu Trp Arg Leu Val Glu Ser Gly Thr Asp Ala 
            20                  25                  30          


Ile Ser Asp Phe Pro Thr Asp Arg Gly Trp Asp Leu Asp Asn Leu Tyr 
        35                  40                  45              


Asp Pro Asp Pro Asp Thr Pro Gly Lys Ala His Asn Val Gln Gly Gly 
    50                  55                  60                  


Phe Leu Asp Ala Ala Gly Phe Asp Ala Ser Phe Phe Gly Ile Ser Pro 
65                  70                  75                  80  


Arg Glu Ala Gln Ala Met Asp Pro Gln Gln Arg Leu Val Leu Glu Thr 
                85                  90                  95      


Ser Trp Glu Ala Phe Glu Arg Ala Gly Ile Asp Pro Ala Ser Val Arg 
            100                 105                 110         


Gly Ser Asp Thr Gly Val Phe Met Gly Ala Phe Gly Ser Gly Tyr Gly 
        115                 120                 125             


Thr Gly Ala Asp Leu Gly Gly Phe Gly Ala Thr Ala Gly Ala Val Ser 
    130                 135                 140                 


Val Leu Ser Gly Arg Val Ser Tyr Leu Phe Gly Leu Glu Gly Pro Ala 
145                 150                 155                 160 


Met Thr Val Asp Thr Ala Cys Ser Ser Ser Leu Val Ala Leu His Gln 
                165                 170                 175     


Ala Ser Ser Ala Leu Arg Gln Asp Glu Cys Ser Leu Ala Leu Val Gly 
            180                 185                 190         


Gly Val Thr Val Met Pro Thr Pro Gln Thr Phe Val Glu Phe Ala Arg 
        195                 200                 205             


Gln Arg Gly Leu Ala Ala Asp Gly Arg Ser Lys Ala Phe Ala Asp Ala 
    210                 215                 220                 


Ala Asp Gly Ala Gly Phe Ser Glu Gly Val Gly Val Leu Val Val Glu 
225                 230                 235                 240 


Arg Leu Ser Asp Ala Arg Ala Lys Gly His Arg Val Leu Ala Val Val 
                245                 250                 255     


Arg Gly Ser Ala Val Asn Gln Asp Gly Ala Ser Asn Gly Leu Thr Ala 
            260                 265                 270         


Pro Asn Gly Pro Ser Gln Gln Arg Val Ile Gln Ser Ala Leu Asp Asn 
        275                 280                 285             


Ala Gly Leu Ser Ser Thr Asp Val Asp Val Val Glu Ala His Gly Thr 
    290                 295                 300                 


Gly Thr Thr Leu Gly Asp Pro Ile Glu Ala Gln Ala Leu Ile Ala Ala 
305                 310                 315                 320 


Tyr Gly Gln Asp Arg Glu Gln Pro Val Leu Leu Gly Ser Leu Lys Ser 
                325                 330                 335     


Asn Ile Gly His Thr Gln Ala Ala Ala Gly Val Ser Gly Val Ile Lys 
            340                 345                 350         


Met Val Met Ala Leu Gln His Gly Val Val Pro Arg Thr Leu His Val 
        355                 360                 365             


Asp Glu Pro Ser Arg His Val Asp Trp Thr Ala Gly Ala Val Glu Leu 
    370                 375                 380                 


Val Thr Glu Asn Gln Pro Trp Pro Ala Ile Asp Arg Ala Arg Arg Ala 
385                 390                 395                 400 


Gly Val Ser Ser Phe Gly Ile Ser Gly Thr Asn Ala His Val Ile Leu 
                405                 410                 415     


Glu Ser Ala Pro Asp Leu Pro Val Val Glu Thr Glu Glu Val Pro Ala 
            420                 425                 430         


Pro Pro Val Val Ala Ser Asp Leu Met Pro Leu Val Ile Ser Ala Lys 
        435                 440                 445             


Thr Pro Ser Ala Leu Ala Asp Met Glu Gly Arg Leu Arg Ala Tyr Leu 
    450                 455                 460                 


Thr Ala Thr Pro Gly Val Asp Met Arg Ala Val Ala Ser Thr Leu Ala 
465                 470                 475                 480 


Gly Thr Arg Ser Val Phe Glu His Arg Ala Val Leu Leu Gly Asp Asp 
                485                 490                 495     


Thr Val Thr Gly Pro Gly Val Ala Val Ser Gly Pro Arg Val Val Phe 
            500                 505                 510         


Val Phe Pro Gly Gln Gly Ser Gln Arg Ala Gly Met Gly Glu Gln Leu 
        515                 520                 525             


Ala Ala Val Phe Pro Val Phe Ala Glu Ile His Gln Gln Val Trp Asp 
    530                 535                 540                 


Leu Leu Asp Val Pro Asp Pro Gly Leu Asp Thr Asp Glu Thr Gly Phe 
545                 550                 555                 560 


Ala Gln Pro Ser Leu Phe Ala Leu Gln Val Ala Leu Phe Gly Leu Leu 
                565                 570                 575     


Glu Ser Trp Gly Val Arg Pro Gln Ala Val Ile Gly His Ser Val Gly 
            580                 585                 590         


Glu Ile Ala Ala Gly Tyr Val Ala Gly Leu Trp Ser Leu Arg Asp Ala 
        595                 600                 605             


Cys Thr Leu Val Ser Ala Arg Ala Arg Leu Met Gln Thr Leu Pro Thr 
    610                 615                 620                 


Gly Gly Ala Met Val Ala Val Pro Val Ser Glu Lys Gln Ala Gln Ala 
625                 630                 635                 640 


Ala Leu Thr Asp Gly Val Glu Ile Ala Ala Val Asn Gly Pro Ser Ser 
                645                 650                 655     


Val Val Leu Thr Gly Asp Glu Thr Ala Val Leu Glu Thr Ala Ala Ala 
            660                 665                 670         


Leu Gly Lys Ser Thr Arg Leu Thr Thr Ser His Ala Phe His Ser Ala 
        675                 680                 685             


Arg Met Glu Pro Val Leu Asp Gln Phe Arg Thr Val Ala Glu Thr Leu 
    690                 695                 700                 


Asp Tyr Arg Thr Pro His Ile Pro Met Ala Ala Gly Asp Ala Val Val 
705                 710                 715                 720 


Thr Pro Glu Tyr Trp Val Arg Gln Ile Arg Asp Thr Val Arg Phe Gly 
                725                 730                 735     


Asp Gln Val Ala Ala His Glu Asn Ala Val Phe Val Glu Ile Gly Pro 
            740                 745                 750         


Asp Arg Thr Leu Ser Arg Leu Thr Asp Gly Ile Ala Met Leu His Gly 
        755                 760                 765             


Asp Asn Glu Thr Gln Thr Ala Ile Thr Ala Leu Ala Thr Leu His Thr 
    770                 775                 780                 


His Gly Val Asn Ile His Trp Pro Thr Ile Val Gly Thr Thr Thr Pro 
785                 790                 795                 800 


Val Leu Asp Leu Pro Thr Tyr Ala Phe Gln His Gln Arg Tyr Trp Thr 
                805                 810                 815     


Ser Trp Leu Ala Gly Leu Ala Pro Glu Glu Arg Lys Gln Ala Leu Leu 
            820                 825                 830         


Lys Thr Val Arg Asp Ser Ala Ala Ala Val Leu Gly His Val Gly Thr 
        835                 840                 845             


Asp Thr Val Pro Ala Thr Ala Ala Phe Lys Asp Leu Gly Leu Asp Ser 
    850                 855                 860                 


Leu Thr Ala Val Glu Leu Arg Asn Ser Leu Gly Lys Ser Thr Gly Leu 
865                 870                 875                 880 


Arg Leu Pro Ala Thr Met Val Phe Asp Tyr Pro Asn Pro Thr Ala Leu 
                885                 890                 895     


Ala Ala Arg Leu Asp 
            900     


<210>  83
<211>  930
<212>  PRT
<213>  Streptomyces filamentosus

<400>  83

Glu Pro Leu Ala Ile Val Gly Met Ala Cys Arg Leu Pro Gly Gly Val 
1               5                   10                  15      


Ser Ser Pro Glu Asp Leu Trp Arg Leu Val Glu Ser Gly Thr Asp Ala 
            20                  25                  30          


Ile Ser Gly Phe Pro Thr Asp Arg Gly Trp Asp Ile Glu Asn Leu Tyr 
        35                  40                  45              


Asp Pro Asp Pro Ala Leu Gly Arg Thr Tyr Thr Val Gln Gly Gly Phe 
    50                  55                  60                  


Leu Asp Ile Ala Gly Phe Asp Ala Ala Phe Phe Gly Ile Ser Pro Arg 
65                  70                  75                  80  


Glu Ala Gln Ala Met Asp Pro Gln Gln Arg Leu Val Leu Glu Ala Ser 
                85                  90                  95      


Trp Glu Ala Phe Glu Arg Ala Gly Ile Glu Pro Gly Ser Met Arg Gly 
            100                 105                 110         


Ser Asp Thr Gly Val Phe Met Gly Ala Phe Ser Ser Gly Tyr Gly Ala 
        115                 120                 125             


Glu His Glu Gly Phe Gly Ala Thr Ala Gly Ala Val Ser Val Leu Ser 
    130                 135                 140                 


Gly Arg Val Ser Tyr Phe Phe Gly Leu Glu Gly Pro Ala Leu Thr Val 
145                 150                 155                 160 


Asp Thr Ala Cys Ser Ser Ser Leu Val Ala Leu His Gln Ala Gly Tyr 
                165                 170                 175     


Ser Leu Arg Gln Gly Glu Cys Ser Leu Ala Leu Val Gly Gly Val Thr 
            180                 185                 190         


Val Met Pro Thr Pro Gln Thr Phe Val Glu Phe Ser Arg Gln Arg Gly 
        195                 200                 205             


Met Ala Val Asp Gly Arg Ser Lys Ala Phe Ala Asp Ala Ala Asp Gly 
    210                 215                 220                 


Ala Gly Trp Ala Glu Gly Val Gly Val Leu Val Val Glu Arg Leu Ser 
225                 230                 235                 240 


Asp Ala Arg Ala Lys Gly His Arg Val Leu Ala Val Val Arg Gly Ser 
                245                 250                 255     


Ala Val Asn Gln Asp Gly Ala Ser Asn Gly Leu Ser Ala Pro Asn Gly 
            260                 265                 270         


Pro Ser Gln Gln Arg Val Ile Arg Gln Ala Leu Ala Asn Ala Gly Leu 
        275                 280                 285             


Ser Ser Ala Asp Val Asp Val Val Glu Ala His Gly Thr Gly Thr Arg 
    290                 295                 300                 


Leu Gly Asp Pro Ile Glu Ala Gln Ala Val Leu Ala Thr Tyr Gly Gln 
305                 310                 315                 320 


Asp Arg Glu Gln Pro Leu Leu Leu Gly Ser Leu Lys Ser Asn Ile Gly 
                325                 330                 335     


His Ala Gln Ala Ala Ala Gly Val Ser Gly Val Ile Lys Met Val Met 
            340                 345                 350         


Ala Leu Gln His Gly Val Val Pro Arg Thr Leu His Val Asp Ser Pro 
        355                 360                 365             


Ser Arg His Val Asp Trp Thr Ala Gly Ser Val Glu Leu Val Thr Glu 
    370                 375                 380                 


Asn Gln Pro Trp Pro Val Leu Glu Arg Ala Arg Arg Val Gly Val Ser 
385                 390                 395                 400 


Ser Phe Gly Ile Ser Gly Thr Asn Ala His Val Ile Leu Glu Ser Ala 
                405                 410                 415     


Pro Asp Pro Asp Val Ala Val Val Glu Val Glu Glu Thr Pro Ala Pro 
            420                 425                 430         


Pro Val Val Val Ile Ser Ala Lys Thr Pro Ser Ala Leu Ala Asp Met 
        435                 440                 445             


Glu Gly Arg Leu Arg Ala Tyr Leu Ala Ala Arg Pro Gly Val Asp Val 
    450                 455                 460                 


Arg Ala Val Ala Ser Thr Leu Ala Gly Thr Arg Ser Val Phe Glu His 
465                 470                 475                 480 


Arg Ala Val Leu Leu Gly Asp Asp Thr Val Thr Gly Thr Ser Thr Gly 
                485                 490                 495     


Thr Gly Ser Gly Ala Ala Val Ser Gly Val Ala Val Ser Gly Pro Arg 
            500                 505                 510         


Val Val Phe Val Phe Pro Gly Gln Gly Trp Gln Trp Leu Gly Met Gly 
        515                 520                 525             


Cys Gly Leu Arg Glu Thr Ser Ala Val Phe Ala Gly Arg Leu Ala Glu 
    530                 535                 540                 


Cys Ala Ala Ala Leu Ser Glu Phe Val Asp Trp Asp Leu Leu Thr Val 
545                 550                 555                 560 


Leu Asp Asp Pro Ser Val Val Asp Arg Val Asp Val Leu Gln Pro Ala 
                565                 570                 575     


Cys Trp Ala Val Met Val Ser Leu Ala Ala Val Trp Gln Glu Ala Gly 
            580                 585                 590         


Val Val Pro Asp Ala Val Ile Gly His Ser Gln Gly Glu Ile Ala Ala 
        595                 600                 605             


Ala Cys Val Ala Gly Ala Leu Thr Leu Arg Asp Ala Ala Arg Ile Val 
    610                 615                 620                 


Ala Leu Arg Ser Arg Leu Ile Ala Arg Leu Ala Gly Gln Gly Ala Met 
625                 630                 635                 640 


Ala Ser Ile Ala Leu Pro Ala His Glu Ile Val Leu Gly Asp Gly Ala 
                645                 650                 655     


Val Val Ala Ala Arg Asn Gly Pro Ala Ala Thr Val Val Ala Gly Thr 
            660                 665                 670         


Ala Arg Ala Val Glu Arg Val Leu Ala Val His Glu Lys Glu Gly Ala 
        675                 680                 685             


Arg Val Arg Arg Ile Thr Val Asp Tyr Ala Ser His Ser Pro Gln Val 
    690                 695                 700                 


Glu Glu Ile Arg Thr Glu Leu Leu Asp Ile Leu Ala Thr Thr Gly Ser 
705                 710                 715                 720 


Arg Thr Pro Val Val Pro Trp Leu Ser Thr Val Asp Gly Thr Trp Thr 
                725                 730                 735     


Glu Gln Pro Leu Asp Pro Asp Tyr Trp Tyr Arg Asn Leu Arg Glu Pro 
            740                 745                 750         


Val Gly Phe His Pro Ala Val Asp Thr Leu Arg Ser Met Gly Glu Thr 
        755                 760                 765             


Val Phe Ile Glu Ile Ser Ala Ser Pro Thr Leu Thr Pro Ala Met Asp 
    770                 775                 780                 


Asp Ala Thr Thr Val Ala Thr Leu Arg Arg Asp Asn Asp Thr Pro Gln 
785                 790                 795                 800 


Gln Ile Leu Thr Ala Leu Ala Glu Ala His Thr His Gly Val Asn Ile 
                805                 810                 815     


His Trp Pro Ala Ile Ile Gly Thr Thr Thr Thr Pro Ala Arg Val Asp 
            820                 825                 830         


Leu Pro Thr Tyr Ala Phe Gln His Gln Arg Tyr Trp Thr Ser Trp Leu 
        835                 840                 845             


Ala Gly Leu Ala Pro Glu Glu Arg Lys Gln Ala Leu Leu Lys Met Val 
    850                 855                 860                 


Arg Asp Ser Ala Ala Ala Val Leu Gly His Ala Gly Ala Asp Thr Val 
865                 870                 875                 880 


Pro Val Thr Ala Ala Phe Lys Asp Leu Gly Leu Asp Ser Leu Thr Ala 
                885                 890                 895     


Val Glu Leu Arg Asn Ser Leu Gly Lys Ser Thr Gly Leu Arg Leu Pro 
            900                 905                 910         


Val Thr Met Val Phe Asp Tyr Pro Asn Pro Thr Thr Leu Ala Ala Arg 
        915                 920                 925             


Leu Asp 
    930 


<210>  84
<211>  931
<212>  PRT
<213>  Streptomyces filamentosus

<400>  84

Glu Pro Leu Ala Ile Val Gly Met Ala Cys Arg Leu Pro Gly Gly Val 
1               5                   10                  15      


Ser Ser Pro Glu Asp Leu Trp Arg Leu Val Glu Ser Gly Thr Asp Ala 
            20                  25                  30          


Ile Ser Gly Phe Pro Thr Asp Arg Gly Trp Asp Ile Glu Asn Leu Tyr 
        35                  40                  45              


Asp Pro Asp Pro Asp Ala Ala Gly Thr Thr Tyr Thr Val Gln Gly Gly 
    50                  55                  60                  


Phe Leu Asp Ile Ala Gly Phe Asp Ala Ser Phe Phe Gly Ile Ser Pro 
65                  70                  75                  80  


Arg Glu Ala Leu Ala Met Asp Pro Gln Gln Arg Leu Val Leu Glu Thr 
                85                  90                  95      


Ser Trp Glu Ala Phe Glu Arg Ala Gly Ile Glu Pro Ser Ser Met Arg 
            100                 105                 110         


Gly Ser Asp Thr Gly Val Phe Met Gly Ala Phe Thr Asn Gly Tyr Gly 
        115                 120                 125             


Ala Gly Val Asp Phe Gly Ala Phe Gly Gly Ala Ser Ala Ala Val Ser 
    130                 135                 140                 


Val Leu Ser Gly Arg Val Ser Tyr Phe Phe Gly Leu Glu Gly Pro Ala 
145                 150                 155                 160 


Ile Thr Val Asp Thr Ala Cys Ser Ser Ser Leu Val Ala Leu His Gln 
                165                 170                 175     


Ala Gly Ser Ala Leu Arg Gln Gly Glu Cys Ser Leu Ala Leu Val Gly 
            180                 185                 190         


Gly Val Thr Val Met Pro Thr Pro Gln Leu Phe Val Asp Phe Ser Arg 
        195                 200                 205             


Gln Arg Gly Leu Ala Ala Asp Gly Arg Ser Lys Ala Phe Ala Asp Pro 
    210                 215                 220                 


Ala Asp Gly Ala Gly Phe Ser Glu Gly Val Gly Val Leu Val Val Glu 
225                 230                 235                 240 


Arg Leu Ser Asp Ala Gln Ala Lys Gly His Arg Val Leu Ala Val Val 
                245                 250                 255     


Arg Gly Ser Ala Val Asn Gln Asp Gly Ala Ser Asn Gly Leu Ser Ala 
            260                 265                 270         


Pro Asn Gly Pro Ser Gln Gln Arg Val Ile Arg Gln Ala Leu Asp Asn 
        275                 280                 285             


Ala Arg Leu Ala Pro Asn Glu Ile Asp Ala Val Glu Ala His Gly Thr 
    290                 295                 300                 


Gly Thr Thr Leu Gly Asp Pro Ile Glu Ala Gln Ala Leu Ile Ala Thr 
305                 310                 315                 320 


Tyr Gly Gln Asp Arg Glu Gln Pro Val Leu Leu Gly Ser Leu Lys Ser 
                325                 330                 335     


Asn Ile Gly His Thr Gln Ala Ala Ala Gly Val Ser Gly Val Ile Lys 
            340                 345                 350         


Met Val Met Ala Leu Gln His Gly Val Val Pro Arg Thr Leu His Val 
        355                 360                 365             


Asp Ser Pro Ser Arg His Val Asp Trp Thr Ala Gly Ala Val Glu Leu 
    370                 375                 380                 


Val Thr Glu Asn Gln Pro Trp Pro Ala Ile Asp Arg Ala Arg Arg Ala 
385                 390                 395                 400 


Gly Val Ser Ser Phe Gly Ile Ser Gly Thr Asn Ala His Val Ile Leu 
                405                 410                 415     


Glu Ser Ala Pro Asp Pro Asp Val Pro Val Val Glu Thr Glu Glu Thr 
            420                 425                 430         


Pro Pro Pro Pro Val Val Val Ile Ser Ala Lys Thr Pro Ser Ala Leu 
        435                 440                 445             


Ala Asp Met Glu Gly Arg Leu Arg Ala Tyr Leu Ala Ala Thr Pro Gly 
    450                 455                 460                 


Val Asp Val Arg Ala Val Ala Ser Thr Leu Ala Gly Thr Arg Ser Val 
465                 470                 475                 480 


Phe Glu His Arg Ala Val Leu Leu Gly Asp Asp Thr Val Thr Gly Thr 
                485                 490                 495     


Ser Thr Gly Thr Gly Ser Gly Ala Ala Val Ser Gly Val Val Val Ser 
            500                 505                 510         


Gly Pro Arg Val Val Phe Val Phe Pro Gly Gln Gly Trp Gln Trp Leu 
        515                 520                 525             


Gly Met Gly Cys Gly Leu Arg Glu Thr Ser Ala Val Phe Ala Gly Arg 
    530                 535                 540                 


Leu Ala Glu Cys Ala Ala Ala Leu Ser Glu Phe Val Asp Trp Asp Leu 
545                 550                 555                 560 


Leu Thr Val Leu Asp Asp Pro Ser Val Val Asp Arg Val Asp Val Leu 
                565                 570                 575     


Gln Pro Ala Cys Trp Ala Val Met Val Ser Leu Ala Ala Val Trp Gln 
            580                 585                 590         


Glu Ala Gly Val Val Pro Asp Ala Val Ile Gly His Ser Gln Gly Glu 
        595                 600                 605             


Ile Ala Ala Ala Cys Val Ala Gly Ala Leu Thr Leu Arg Asp Ala Ala 
    610                 615                 620                 


Arg Ile Val Ala Leu Arg Ser Arg Leu Ile Ala Arg Leu Ala Gly Gln 
625                 630                 635                 640 


Gly Ala Met Ala Ser Ile Ala Leu Pro Ala His Glu Ile Ala Leu Gly 
                645                 650                 655     


Asp Gly Ala Val Val Ala Ala Arg Asn Gly Arg Ala Ala Thr Val Ile 
            660                 665                 670         


Ala Gly Thr Ala Arg Ala Val Asp Arg Val Leu Ala Val His Glu Lys 
        675                 680                 685             


Glu Gly Ala Arg Val Arg Arg Ile Thr Val Asp Tyr Ala Ser His Ser 
    690                 695                 700                 


Pro Gln Val Glu Glu Ile Arg Thr Glu Leu Leu Asp Ile Leu Ala Thr 
705                 710                 715                 720 


Thr Gly Ser Arg Thr Pro Val Val Pro Trp Leu Ser Thr Val Asp Gly 
                725                 730                 735     


Thr Trp Thr Glu Gln Pro Leu Asp Pro Asp Tyr Trp Tyr Arg Asn Leu 
            740                 745                 750         


Arg Glu Pro Val Gly Phe His Pro Ala Val Asp Thr Leu Arg Ser Met 
        755                 760                 765             


Gly Glu Thr Val Phe Ile Glu Ile Ser Ala Ser Pro Thr Leu Thr Pro 
    770                 775                 780                 


Ala Met Asp Asp Ala Thr Thr Val Ala Thr Leu Arg Arg Asp Asn Asp 
785                 790                 795                 800 


Thr Pro Gln Gln Ile Leu Thr Ala Leu Ala Glu Ala His Thr His Gly 
                805                 810                 815     


Val Asn Ile His Trp Pro Ala Ile Met Gly Ala Thr Thr Thr Arg Val 
            820                 825                 830         


Asp Leu Pro Thr Tyr Ala Phe Gln His Gln Arg Tyr Trp Thr Ser Trp 
        835                 840                 845             


Leu Ala Gly Leu Ala Pro Glu Glu Arg Lys Gln Ala Leu Leu Lys Val 
    850                 855                 860                 


Val Arg Asp Ser Ala Ala Lys Val Leu Gly His Ala Gly Ala Asp Thr 
865                 870                 875                 880 


Val Pro Val Thr Ala Ala Phe Lys Asp Leu Gly Leu Asp Ser Leu Thr 
                885                 890                 895     


Ala Val Glu Leu Arg Asn Ser Leu Gly Lys Ser Thr Gly Leu Arg Leu 
            900                 905                 910         


Pro Ala Thr Met Val Phe Asp Tyr Pro Asn Pro Thr Thr Leu Ala Ala 
        915                 920                 925             


Arg Leu Asp 
    930     


<210>  85
<211>  910
<212>  PRT
<213>  Streptomyces filamentosus

<400>  85

Glu Pro Leu Ala Ile Val Gly Met Ala Cys Arg Leu Pro Gly Gly Val 
1               5                   10                  15      


Ser Ser Pro Glu Asp Leu Trp Arg Leu Val Glu Ser Gly Thr Asp Ala 
            20                  25                  30          


Ile Ser Gly Phe Pro Thr Asp Arg Gly Trp Asp Ile Glu Asn Leu Tyr 
        35                  40                  45              


Asp Pro Asp Pro Asp Ala Pro Gly Lys Gly Tyr Arg Val Gln Gly Gly 
    50                  55                  60                  


Phe Leu Asp Arg Ala Ala Glu Phe Asp Ala Ser Phe Phe Gly Ile Ser 
65                  70                  75                  80  


Pro Arg Glu Ala Gln Ala Met Asp Pro Gln Gln Arg Leu Val Leu Glu 
                85                  90                  95      


Thr Ser Trp Glu Ala Phe Glu Arg Ala Gly Ile Glu Pro Gly Ala Met 
            100                 105                 110         


Arg Gly Ser Asp Thr Gly Val Phe Met Gly Ala Met Ala Asn Gly Tyr 
        115                 120                 125             


Gly Thr Gly Ala Asp Leu Gly Ala Phe Gly Met Thr Ser Ala Ala Val 
    130                 135                 140                 


Ser Val Leu Ser Gly Arg Val Ser Tyr Leu Phe Gly Leu Glu Gly Pro 
145                 150                 155                 160 


Ala Met Thr Val Asp Thr Ala Cys Ser Ser Ser Leu Val Ala Leu His 
                165                 170                 175     


Gln Ala Ala Tyr Ser Leu Arg Gln Gly Glu Cys Ser Leu Ala Leu Val 
            180                 185                 190         


Gly Gly Val Thr Val Met Pro Thr Pro Gln Thr Phe Val Glu Phe Ala 
        195                 200                 205             


Arg Gln Arg Gly Leu Ala Ala Asp Gly Arg Ser Lys Ala Phe Ser Asp 
    210                 215                 220                 


Ala Ala Asp Gly Ala Gly Phe Ser Glu Gly Val Gly Val Leu Val Val 
225                 230                 235                 240 


Glu Arg Leu Ser Asp Ala Arg Ala Lys Gly His His Val Leu Ala Val 
                245                 250                 255     


Val Arg Gly Ser Ala Val Asn Gln Asp Gly Ala Ser Asn Gly Leu Ser 
            260                 265                 270         


Ala Pro Asn Gly Pro Ser Gln Gln Arg Val Ile Arg Gln Ala Leu Asp 
        275                 280                 285             


Asn Ala Gly Leu Ser Ser Thr Asp Val Asp Val Val Glu Ala His Gly 
    290                 295                 300                 


Thr Gly Thr Thr Leu Gly Asp Pro Ile Glu Ala Gln Ala Leu Ile Ala 
305                 310                 315                 320 


Thr Tyr Gly Gln Asp Arg Glu Gln Pro Val Leu Leu Gly Ser Leu Lys 
                325                 330                 335     


Ser Asn Ile Gly His Thr Gln Ala Ala Ala Gly Val Ser Gly Val Ile 
            340                 345                 350         


Lys Met Val Met Ala Leu Gln His Gly Val Val Pro Arg Thr Leu His 
        355                 360                 365             


Val Asp Ser Pro Ser Arg His Val Asp Trp Thr Ala Gly Ala Val Glu 
    370                 375                 380                 


Leu Val Thr Glu Asn Gln Pro Trp Pro Ala Ile Asp Arg Ala Arg Arg 
385                 390                 395                 400 


Val Gly Val Ser Ser Phe Gly Ile Ser Gly Thr Asn Ala His Val Ile 
                405                 410                 415     


Leu Glu Ser Ala Pro Ala Gln Pro Val Val Glu Thr Glu Glu Val Pro 
            420                 425                 430         


Ala Pro Pro Val Val Ala Ser Asp Met Met Pro Leu Val Ile Ser Ala 
        435                 440                 445             


Lys Thr Pro Ser Ala Leu Val Glu Phe Glu Gly Arg Leu Arg Ala Tyr 
    450                 455                 460                 


Leu Thr Ser Thr Pro Gly Val Asp Met Arg Ala Val Ala Ser Thr Leu 
465                 470                 475                 480 


Ala Gly Thr Arg Ser Val Phe Glu His Arg Ala Val Leu Leu Gly Asp 
                485                 490                 495     


Asp Thr Val Thr Gly Pro Asp Thr Gly Thr Gly Ala Gly Ser Gly Val 
            500                 505                 510         


Ala Val Ser Asp Pro Arg Val Val Phe Val Phe Pro Gly Gln Gly Ser 
        515                 520                 525             


Gln Arg Ala Gly Met Gly Glu Gln Leu Ala Ala Val Phe Pro Val Phe 
    530                 535                 540                 


Ala Glu Ile His Gln Gln Val Trp Asp Leu Leu Asp Val Pro Asp Pro 
545                 550                 555                 560 


Gly Leu Gly Ala Asp Glu Thr Gly Phe Ala Gln Pro Ser Leu Phe Ala 
                565                 570                 575     


Leu Gln Val Ala Leu Phe Gly Leu Leu Glu Ser Trp Gly Val Arg Pro 
            580                 585                 590         


Gln Ala Val Ile Gly His Ser Val Gly Glu Ile Ala Ala Gly Tyr Val 
        595                 600                 605             


Ala Gly Leu Trp Ser Leu Arg Asp Ala Cys Thr Leu Val Ser Ala Arg 
    610                 615                 620                 


Ala Arg Leu Met Gln Thr Leu Pro Thr Gly Gly Ala Met Val Ala Val 
625                 630                 635                 640 


Pro Val Ser Glu Lys Gln Ala Gln Ala Ala Leu Thr Asp Gly Val Glu 
                645                 650                 655     


Ile Ala Ala Val Asn Gly Pro Ser Ser Val Val Leu Thr Gly Asp Glu 
            660                 665                 670         


Thr Ala Val Leu Glu Thr Ala Ala Ala Leu Gly Lys Ser Thr Arg Leu 
        675                 680                 685             


Thr Thr Ser His Ala Phe His Ser Ala Arg Met Glu Pro Val Leu Asp 
    690                 695                 700                 


Gln Phe Arg Thr Val Ala Glu Thr Leu Asp Tyr Arg Thr Pro His Ile 
705                 710                 715                 720 


Pro Met Ala Ala Gly Asp Ala Val Val Thr Pro Glu Tyr Trp Val Arg 
                725                 730                 735     


Gln Ile Arg Asp Thr Val Arg Phe Gly Asp Gln Val Ala Ala His Glu 
            740                 745                 750         


Asn Ala Val Phe Val Glu Ile Gly Pro Asp Arg Thr Leu Ser Arg Leu 
        755                 760                 765             


Thr Asp Gly Ile Ala Met Leu His Gly Asp Asn Glu Thr Gln Thr Ala 
    770                 775                 780                 


Ile Thr Ala Leu Ala Thr Leu His Thr His Gly Val Asn Ile His Trp 
785                 790                 795                 800 


Pro Ala Val Ile Gly Ala Thr Thr Ala Arg Val Leu Asp Leu Pro Thr 
                805                 810                 815     


Tyr Ala Phe Glu Arg Gln Arg Tyr Trp Ala Trp Leu Ala Gly Leu Ala 
            820                 825                 830         


Pro Glu Glu Arg Lys Gln Ala Leu Leu Lys Val Val Arg Asp Ser Ala 
        835                 840                 845             


Ala Ala Val Leu Gly His Ala Asp Ala Arg Asp Ile Ala Val Asn Thr 
    850                 855                 860                 


Ala Phe Arg Asp Leu Gly Leu Asp Ser Leu Thr Ala Val Gln Val Arg 
865                 870                 875                 880 


Asn Ser Leu Ala Lys Ala Thr Gly Leu Arg Leu Pro Thr Thr Thr Val 
                885                 890                 895     


Phe Asp Tyr Pro Asn Pro Thr Ala Leu Ala Thr His Leu Asp 
            900                 905                 910 


<210>  86
<211>  910
<212>  PRT
<213>  Streptomyces filamentosus

<400>  86

Glu Pro Leu Ala Ile Val Gly Met Ala Cys Arg Leu Pro Gly Gly Val 
1               5                   10                  15      


Ser Ser Pro Glu Asp Leu Trp Arg Leu Val Glu Ser Gly Thr Asp Ala 
            20                  25                  30          


Ile Ser Asp Phe Pro Thr Asp Arg Gly Trp Asp Leu Asp Asn Leu Tyr 
        35                  40                  45              


Asp Pro Asp Pro Asp Thr Pro Gly Lys Ala His Asn Val Gln Gly Gly 
    50                  55                  60                  


Phe Leu Asp Ala Ala Gly Phe Asp Ala Ala Phe Phe Gly Ile Ser Pro 
65                  70                  75                  80  


Arg Glu Ala Leu Ala Met Asp Pro Gln Gln Arg Leu Val Leu Glu Thr 
                85                  90                  95      


Ser Trp Glu Ala Phe Glu Arg Ala Gly Ile Asp Pro Ala Ser Val Arg 
            100                 105                 110         


Gly Ser Asp Thr Gly Val Phe Met Gly Ala Phe Gly Ser Gly Tyr Gly 
        115                 120                 125             


Thr Gly Ala Asp Leu Gly Gly Phe Gly Ala Thr Ala Gly Ala Val Ser 
    130                 135                 140                 


Val Leu Ser Gly Arg Val Ser Tyr Leu Phe Gly Leu Glu Gly Pro Ala 
145                 150                 155                 160 


Met Thr Val Asp Thr Ala Cys Ser Ser Ser Leu Val Ala Leu His Gln 
                165                 170                 175     


Ala Ser Ser Ala Leu Arg Gln Asp Glu Cys Ser Leu Ala Leu Val Gly 
            180                 185                 190         


Gly Val Thr Val Met Pro Thr Pro Gln Thr Phe Val Glu Phe Ala Arg 
        195                 200                 205             


Gln Arg Gly Leu Ala Ala Asp Gly Arg Ser Lys Ala Phe Ala Asp Ala 
    210                 215                 220                 


Ala Asp Gly Ala Gly Phe Ser Glu Gly Val Gly Val Leu Val Val Glu 
225                 230                 235                 240 


Arg Leu Ser Asp Ala Arg Ala Lys Gly His Arg Val Leu Ala Val Val 
                245                 250                 255     


Arg Gly Ser Ala Val Asn Gln Asp Gly Ala Ser Asn Gly Leu Thr Ala 
            260                 265                 270         


Pro Asn Gly Pro Ser Gln Gln Arg Val Ile Arg Gln Ala Leu Asp Asn 
        275                 280                 285             


Ala Gly Leu Ser Ser Thr Asp Val Asp Val Val Glu Ala His Gly Thr 
    290                 295                 300                 


Gly Thr Arg Leu Gly Asp Pro Ile Glu Ala Gln Ala Leu Ile Ala Thr 
305                 310                 315                 320 


Tyr Gly Gln Asp Arg Glu Gln Pro Val Leu Leu Gly Ser Leu Lys Ser 
                325                 330                 335     


Asn Ile Gly His Thr Gln Ala Ala Ala Gly Val Ser Gly Val Ile Lys 
            340                 345                 350         


Met Val Met Ala Leu Gln His Gly Val Val Pro Arg Thr Leu His Val 
        355                 360                 365             


Asp Ser Pro Ser Arg His Val Asp Trp Thr Ala Gly Ala Val Glu Leu 
    370                 375                 380                 


Val Thr Glu Asn Gln Pro Trp Pro Ala Ile Asp Arg Ala Arg Arg Val 
385                 390                 395                 400 


Gly Val Ser Ser Phe Gly Ile Ser Gly Thr Asn Ala His Val Ile Leu 
                405                 410                 415     


Glu Ser Ala Pro Ala Gln Pro Val Val Glu Thr Glu Glu Val Pro Ala 
            420                 425                 430         


Pro Pro Val Val Ala Ser Asp Met Met Pro Leu Val Ile Ser Ala Lys 
        435                 440                 445             


Thr Pro Ser Ala Leu Val Glu Phe Glu Gly Arg Leu Arg Ala Tyr Leu 
    450                 455                 460                 


Thr Ser Thr Pro Gly Val Asp Met Arg Ala Val Ala Ser Thr Leu Ala 
465                 470                 475                 480 


Gly Thr Arg Ser Val Phe Glu His Arg Ala Val Leu Leu Gly Asp Asp 
                485                 490                 495     


Thr Val Thr Gly Pro Asp Thr Gly Thr Gly Ala Gly Ser Gly Val Ala 
            500                 505                 510         


Val Ser Asp Pro Arg Val Val Phe Val Phe Pro Gly Gln Gly Ser Gln 
        515                 520                 525             


Arg Ala Gly Met Gly Glu Gln Leu Ala Ala Val Phe Pro Val Phe Ala 
    530                 535                 540                 


Glu Ile His Gln Gln Val Trp Asp Leu Leu Asp Val Pro Asp Pro Gly 
545                 550                 555                 560 


Leu Asp Thr Asp Glu Thr Gly Tyr Ala Gln Pro Ser Leu Phe Ala Leu 
                565                 570                 575     


Gln Val Ala Leu Phe Gly Leu Leu Glu Ser Trp Gly Val Arg Pro Gln 
            580                 585                 590         


Ala Val Ile Gly His Ser Val Gly Glu Ile Ala Ala Gly Tyr Val Ala 
        595                 600                 605             


Gly Leu Trp Ser Leu Arg Asp Ala Cys Thr Leu Val Ser Ala Arg Ala 
    610                 615                 620                 


Arg Leu Met Gln Thr Leu Pro Thr Gly Gly Ala Met Val Ala Val Pro 
625                 630                 635                 640 


Val Ser Glu Lys Gln Ala Gln Ala Ala Leu Thr Asp Gly Val Glu Ile 
                645                 650                 655     


Ala Ala Val Asn Gly Pro Ser Ser Val Val Leu Thr Gly Asp Glu Thr 
            660                 665                 670         


Ala Val Leu Glu Thr Ala Ala Ala Leu Gly Arg Ser Thr Arg Leu Thr 
        675                 680                 685             


Thr Ser His Ala Phe His Ser Ala Arg Met Glu Pro Val Leu Asp Glu 
    690                 695                 700                 


Phe Arg Thr Val Ala Glu Thr Leu Asp Tyr Arg Thr Pro His Ile Pro 
705                 710                 715                 720 


Met Ala Ala Gly Asp Ala Val Val Thr Pro Glu Tyr Trp Val Arg Gln 
                725                 730                 735     


Ile Arg Asp Thr Val Arg Phe Gly Asp Gln Val Ala Ala His Glu Asn 
            740                 745                 750         


Ala Val Phe Val Glu Ile Gly Pro Asp Arg Thr Leu Ser Arg Leu Thr 
        755                 760                 765             


Asp Gly Ile Ala Met Leu His Gly Asp Asn Glu Thr Gln Thr Ala Ile 
    770                 775                 780                 


Thr Ala Leu Ala Thr Leu His Thr His Gly Val Asn Ile His Trp Pro 
785                 790                 795                 800 


Ala Val Ile Gly Ala Thr Thr Ala Arg Val Leu Asp Met Pro Thr Tyr 
                805                 810                 815     


Ala Phe Gln His Gln Arg Tyr Trp Thr Thr Trp Leu Ala Gly Leu Thr 
            820                 825                 830         


Pro Glu Glu Arg Lys Gln Ala Leu Leu Lys Thr Val Arg Asp Ser Ala 
        835                 840                 845             


Ala Ala Val Leu Gly His Ala Asp Ala Arg Asp Ile Ala Val Asn Thr 
    850                 855                 860                 


Ala Phe Arg Asp Leu Gly Leu Asp Ser Leu Thr Ala Val Gln Val Arg 
865                 870                 875                 880 


Asn Ser Leu Ala Lys Ala Thr Gly Leu Arg Leu Pro Thr Thr Thr Val 
                885                 890                 895     


Phe Asp Tyr Pro Asn Pro Thr Ala Leu Ala Thr His Leu Asp 
            900                 905                 910 


<210>  87
<211>  938
<212>  PRT
<213>  Streptomyces filamentosus

<400>  87

Glu Pro Leu Ala Ile Val Gly Met Ala Cys Arg Leu Pro Gly Gly Val 
1               5                   10                  15      


Ser Ser Pro Glu Asp Leu Trp Gln Leu Val Glu Ser Gly Thr Asp Ala 
            20                  25                  30          


Ile Ser His Phe Pro Thr Asp Arg Gly Trp Asp Ile Asp Asn Leu Tyr 
        35                  40                  45              


Asp Pro Asp Pro Asp Thr Pro Gly Lys Thr Tyr Cys Val Gln Gly Tyr 
    50                  55                  60                  


Phe Leu Asp Gly Ile Ala Glu Phe Asp Ala Ser Phe Phe Gly Thr Ser 
65                  70                  75                  80  


Pro Arg Glu Ala Leu Ala Met Asp Pro Gln Gln Arg Leu Val Leu Glu 
                85                  90                  95      


Thr Ser Trp Glu Ala Phe Glu Arg Ala Gly Ile Asp Pro Ala Ser Val 
            100                 105                 110         


Arg Gly Ser Asp Thr Gly Val Phe Met Gly Ala Phe Ser Ser Gly Tyr 
        115                 120                 125             


Gly Thr Gly Ala Asp Leu Gly Gly Phe Gly Ala Thr Ala Gly Ala Gly 
    130                 135                 140                 


Ser Val Leu Ser Gly Arg Val Ser Tyr Leu Phe Gly Leu Glu Gly Pro 
145                 150                 155                 160 


Ala Met Thr Val Asp Thr Ala Cys Ser Ser Ser Leu Val Ala Leu His 
                165                 170                 175     


Gln Ala Gly Tyr Ser Leu Arg Gln Gly Glu Cys Ser Leu Ala Leu Val 
            180                 185                 190         


Gly Gly Val Thr Val Met Pro Thr Pro Gln Ala Phe Val Glu Phe Ser 
        195                 200                 205             


Arg Gln Arg Gly Leu Ala Ala Asp Gly Arg Ser Lys Ala Phe Ala Asp 
    210                 215                 220                 


Ala Ala Asp Gly Ala Gly Trp Ala Glu Gly Val Gly Val Leu Val Val 
225                 230                 235                 240 


Glu Arg Leu Ser Asp Ala Arg Ala Lys Gly His Arg Val Leu Ala Val 
                245                 250                 255     


Val Arg Gly Ser Ala Val Asn Gln Asp Gly Ala Ser Asn Gly Leu Thr 
            260                 265                 270         


Ala Pro Asn Gly Pro Ser Gln Gln Arg Val Ile Arg Ser Ala Leu Asp 
        275                 280                 285             


Asn Ala Arg Leu Ala Pro Asn Glu Ile Asp Val Val Glu Ala His Gly 
    290                 295                 300                 


Thr Gly Thr Arg Leu Gly Asp Pro Ile Glu Ala Gln Ala Leu Ile Ala 
305                 310                 315                 320 


Ala Tyr Gly Gln Asp Arg Glu Gln Pro Val Leu Leu Gly Ser Leu Lys 
                325                 330                 335     


Ser Asn Ile Gly His Thr Gln Ala Ala Ala Gly Val Ser Gly Val Ile 
            340                 345                 350         


Lys Met Val Met Ala Leu Gln His Gly Val Val Pro Arg Thr Leu His 
        355                 360                 365             


Val Asp Glu Pro Ser Arg His Val Asp Trp Thr Ala Gly Ala Val Glu 
    370                 375                 380                 


Leu Val Thr Glu Asn Gln Pro Trp Pro Ala Ile Asp Arg Ala Arg Arg 
385                 390                 395                 400 


Ala Gly Val Ser Ser Phe Gly Ile Ser Gly Thr Asn Ala His Val Ile 
                405                 410                 415     


Leu Glu Ser Pro Pro Ala Gln Pro Val Val Glu Thr Glu Glu Val Pro 
            420                 425                 430         


Ala Pro Pro Val Val Ala Ser Asp Met Met Pro Leu Val Ile Ser Ala 
        435                 440                 445             


Lys Thr Pro Ser Ala Leu Ala Asp Met Glu Gly Arg Leu Arg Ala Tyr 
    450                 455                 460                 


Leu Ala Ala Arg Pro Gly Val Asp Val Arg Ala Val Ala Ser Thr Leu 
465                 470                 475                 480 


Ala Gly Thr Arg Ser Val Phe Glu His Arg Ala Val Leu Leu Gly Asp 
                485                 490                 495     


Asp Thr Val Thr Gly Thr Ser Thr Gly Thr Gly Ser Gly Ala Ala Val 
            500                 505                 510         


Ser Gly Val Val Val Ser Gly Pro Arg Val Val Phe Val Phe Pro Gly 
        515                 520                 525             


Gln Gly Trp Gln Trp Leu Gly Met Gly Cys Gly Leu Arg Glu Thr Ser 
    530                 535                 540                 


Ala Val Phe Ala Gly Arg Leu Ala Glu Cys Ala Ala Ala Leu Ser Glu 
545                 550                 555                 560 


Phe Val Asp Trp Asp Leu Leu Thr Val Leu Asp Asp Pro Ser Val Val 
                565                 570                 575     


Asp Arg Val Asp Val Leu Gln Pro Ala Cys Trp Ala Val Met Val Ser 
            580                 585                 590         


Leu Ala Ala Val Trp Gln Glu Ala Gly Val Val Pro Asp Ala Val Ile 
        595                 600                 605             


Gly His Ser Gln Gly Glu Ile Ala Ala Ala Cys Val Ala Gly Ala Leu 
    610                 615                 620                 


Thr Leu Arg Asp Ala Ala Arg Ile Val Ala Leu Arg Ser Arg Leu Ile 
625                 630                 635                 640 


Ala Arg Leu Ala Gly Gln Gly Ala Met Ala Ser Ile Ala Leu Pro Ala 
                645                 650                 655     


His Glu Ile Ala Leu Gly Asp Gly Ala Val Val Ala Ala Arg Asn Gly 
            660                 665                 670         


Pro Ala Ala Thr Val Ile Ala Gly Thr Pro Arg Ala Val Asp Arg Val 
        675                 680                 685             


Leu Ala Val His Glu Lys Glu Gly Ala Arg Val Arg Arg Ile Thr Val 
    690                 695                 700                 


Asp Tyr Ala Ser His Ser Pro Gln Val Glu Glu Ile Arg Thr Glu Leu 
705                 710                 715                 720 


Leu Asp Ile Leu Ala Thr Thr Gly Ser Arg Thr Pro Val Val Pro Trp 
                725                 730                 735     


Leu Ser Thr Val Asp Gly Thr Trp Thr Glu Gln Pro Leu Asp Pro Asp 
            740                 745                 750         


Tyr Trp Tyr Arg Asn Leu Arg Glu Pro Val Gly Phe His Pro Ala Val 
        755                 760                 765             


Asp Thr Leu Arg Ser Met Gly Glu Thr Val Phe Ile Glu Ile Ser Ala 
    770                 775                 780                 


Ser Pro Thr Leu Thr Pro Ala Met Asp Asp Ala Thr Thr Val Ala Thr 
785                 790                 795                 800 


Leu Arg Arg Asp Asn Asp Thr Pro Arg Gln Ile Leu Thr Ala Leu Ala 
                805                 810                 815     


Glu Ala His Thr His Gly Val Asn Ile His Trp Pro Thr Val Ile Gly 
            820                 825                 830         


Thr Thr Thr Thr Pro Ala Arg Val Asp Leu Pro Thr Tyr Ala Phe Gln 
        835                 840                 845             


His Gln Arg Tyr Trp Thr Ser Trp Leu Ala Gly Leu Ala Pro Ala Glu 
    850                 855                 860                 


Arg Asp Glu Ala Leu Leu Lys Met Val Arg Asp Ser Ala Ala Leu Val 
865                 870                 875                 880 


Leu Gly His Ala Gly Gly Arg Thr Ile Pro Val Ala Ala Ala Phe Lys 
                885                 890                 895     


Asp Leu Gly Val Asp Ser Leu Thr Ala Val Glu Leu Arg Asn Arg Leu 
            900                 905                 910         


Ser Ala Ala Thr Gly Leu Arg Leu Pro Ala Thr Leu Val Phe Asp Tyr 
        915                 920                 925             


Pro Asn Pro Ala Ala Leu Ala Gly Trp Leu 
    930                 935             


<210>  88
<211>  931
<212>  PRT
<213>  Streptomyces filamentosus

<400>  88

Gln Pro Leu Ala Ile Val Gly Met Ala Cys Arg Leu Pro Gly Gly Val 
1               5                   10                  15      


Ser Ser Pro Glu Asp Leu Trp Arg Leu Val Glu Ser Gly Thr Asp Ala 
            20                  25                  30          


Ile Ser Asp Phe Pro Thr Asp Arg Gly Trp Asp Ile Glu Asn Leu Tyr 
        35                  40                  45              


Asp Pro Asp Ser Pro Gly Glu Gly Glu Ala Tyr Ser Ala Gln Gly Gly 
    50                  55                  60                  


Phe Leu Asp Ala Ala Gly Phe Asp Ala Ala Phe Phe Gly Ile Ser Pro 
65                  70                  75                  80  


Arg Glu Ala Gln Ala Met Asp Pro Gln Gln Arg Leu Val Leu Glu Ala 
                85                  90                  95      


Ser Trp Glu Ala Phe Glu Arg Ala Gly Ile Asp Pro Gly Ala Met Arg 
            100                 105                 110         


Gly Ser His Thr Gly Val Phe Met Gly Ala Met Ala Asn Gly Tyr Gly 
        115                 120                 125             


Ala Gly Ala Asp Leu Gly Gly Phe Gly Ala Thr Ala Gly Ala Gly Ser 
    130                 135                 140                 


Val Leu Ser Gly Arg Ile Ser Tyr Leu Phe Gly Leu Glu Gly Pro Ala 
145                 150                 155                 160 


Met Thr Val Asp Thr Ala Cys Ser Ser Ser Leu Val Ala Leu His Gln 
                165                 170                 175     


Ala Ala Tyr Ser Leu Arg Gln Gly Glu Cys Ser Leu Ala Leu Val Gly 
            180                 185                 190         


Gly Val Thr Val Met Ala Thr Thr Gln Thr Phe Val Glu Phe Ala Arg 
        195                 200                 205             


Gln Arg Gly Leu Ala Ala Asp Gly Arg Ser Lys Ala Phe Ala Asp Ala 
    210                 215                 220                 


Ala Asp Gly Ala Gly Trp Ala Glu Gly Val Gly Val Leu Val Val Glu 
225                 230                 235                 240 


Arg Leu Ser Asp Ala Arg Ala Lys Gly His Arg Val Leu Ala Val Val 
                245                 250                 255     


Arg Gly Ser Ala Val Asn Gln Asp Gly Ala Ser Asn Gly Leu Thr Ala 
            260                 265                 270         


Pro Asn Gly Pro Ser Gln Gln Arg Val Ile Arg Ser Ala Leu Asp Asn 
        275                 280                 285             


Ala Gly Leu Ser Ser Ala Asp Val Asp Val Val Glu Ala His Gly Thr 
    290                 295                 300                 


Gly Thr Thr Leu Gly Asp Pro Ile Glu Ala Gln Ala Leu Ile Ala Ala 
305                 310                 315                 320 


Tyr Gly Gln Asp Arg Glu Gln Pro Val Leu Leu Gly Ser Leu Lys Ser 
                325                 330                 335     


Asn Ile Gly His Ala Gln Ala Ala Ala Gly Val Ser Gly Val Ile Lys 
            340                 345                 350         


Met Val Met Ala Leu Gln His Gly Val Val Pro Arg Thr Leu His Val 
        355                 360                 365             


Asp Ser Pro Ser Arg His Val Asp Trp Thr Ala Gly Ala Val Glu Leu 
    370                 375                 380                 


Val Thr Glu Asn Gln Pro Trp Pro Val Thr Glu Arg Ala Arg Arg Ala 
385                 390                 395                 400 


Gly Val Ser Ser Phe Gly Ile Ser Gly Thr Asn Ala His Val Ile Leu 
                405                 410                 415     


Glu Ser Ala Pro Asp Pro Asp Val Pro Val Val Glu Thr Glu Lys Val 
            420                 425                 430         


Pro Ala Pro Pro Val Val Val Ile Ser Ala Lys Thr Pro Ser Ala Leu 
        435                 440                 445             


Val Glu Phe Glu Gly Arg Leu Arg Ala Tyr Leu Ala Ala Arg Pro Gly 
    450                 455                 460                 


Val Asp Val Arg Ala Val Ala Ser Thr Leu Ala Gly Thr Arg Ser Val 
465                 470                 475                 480 


Phe Gly His Arg Ala Val Leu Leu Gly Asp Asp Thr Val Thr Gly Thr 
                485                 490                 495     


Ser Thr Gly Thr Gly Ser Gly Ala Ala Val Ser Gly Val Val Val Ser 
            500                 505                 510         


Gly Pro Arg Val Val Phe Val Phe Pro Gly Gln Gly Trp Gln Trp Leu 
        515                 520                 525             


Gly Met Gly Cys Gly Leu Arg Glu Thr Ser Ala Val Phe Ala Gly Arg 
    530                 535                 540                 


Leu Ala Glu Cys Ala Ala Ala Leu Ser Glu Phe Val Asp Trp Asp Leu 
545                 550                 555                 560 


Leu Thr Val Leu Asp Asp Pro Ser Val Val Asp Arg Val Asp Val Leu 
                565                 570                 575     


Gln Pro Ala Cys Trp Ala Val Met Val Ser Leu Ala Ala Val Trp Gln 
            580                 585                 590         


Glu Ala Gly Val Val Pro Asp Ala Val Ile Gly His Ser Gln Gly Glu 
        595                 600                 605             


Ile Ala Ala Ala Cys Val Ala Gly Ala Leu Thr Leu Arg Asp Ala Ala 
    610                 615                 620                 


Arg Ile Val Ala Leu Arg Ser Arg Leu Ile Ala Arg Leu Ala Gly Gln 
625                 630                 635                 640 


Gly Ala Met Ala Ser Ile Ala Leu Pro Ala His Glu Ile Ala Leu Gly 
                645                 650                 655     


Asp Gly Ala Val Val Ala Ala Leu Asn Gly Pro Ala Ala Thr Val Ile 
            660                 665                 670         


Ala Gly Thr Pro Arg Ala Val Asp Arg Val Leu Ala Val His Glu Lys 
        675                 680                 685             


Glu Gly Ala Arg Val Arg Arg Ile Thr Val Asp Tyr Ala Ser His Ser 
    690                 695                 700                 


Pro Gln Val Glu Glu Ile Arg Thr Glu Leu Leu Asp Ile Leu Ala Thr 
705                 710                 715                 720 


Thr Gly Ser Arg Thr Pro Val Val Pro Trp Leu Ser Thr Val Asp Gly 
                725                 730                 735     


Thr Trp Thr Glu Gln Pro Leu Asp Pro Asp Tyr Trp Tyr Arg Asn Leu 
            740                 745                 750         


Arg Glu Pro Val Gly Phe His Pro Ala Val Asp Thr Leu Arg Ser Met 
        755                 760                 765             


Gly Glu Thr Val Phe Ile Glu Ile Ser Ala Ser Pro Thr Leu Thr Pro 
    770                 775                 780                 


Ala Met Asp Asp Ala Thr Thr Val Ala Thr Leu Arg Arg Asp Asn Asp 
785                 790                 795                 800 


Thr Pro Gln Gln Ile Leu Thr Ala Leu Ala Glu Ala His Thr His Gly 
                805                 810                 815     


Val Asn Ile His Trp Pro Thr Val Met Gly Ala Thr Thr Thr Arg Val 
            820                 825                 830         


Asp Leu Pro Thr Tyr Ala Phe Gln His Gln Arg Tyr Trp Thr Ser Trp 
        835                 840                 845             


Leu Ala Gly Leu Ala Pro Glu Glu Arg Lys Gln Ala Leu Leu Lys Val 
    850                 855                 860                 


Val Arg Asp Ser Ala Ala Ala Val Leu Gly His Ala Gly Thr Asp Thr 
865                 870                 875                 880 


Val Pro Val Thr Ala Ala Phe Lys Asp Leu Gly Leu Asp Ser Leu Thr 
                885                 890                 895     


Ala Val Glu Leu Arg Asn Ser Leu Gly Lys Ser Thr Gly Leu Arg Leu 
            900                 905                 910         


Pro Ala Thr Leu Val Phe Asp Tyr Pro Asn Pro Thr Thr Leu Ala Ala 
        915                 920                 925             


Arg Leu Asp 
    930     


<210>  89
<211>  929
<212>  PRT
<213>  Streptomyces filamentosus

<400>  89

Glu Pro Leu Ala Ile Val Gly Met Ala Cys Arg Leu Pro Gly Gly Val 
1               5                   10                  15      


Ser Ser Pro Glu Asp Leu Trp Arg Leu Val Glu Ser Gly Thr Asp Ala 
            20                  25                  30          


Ile Ser Gly Phe Pro Thr Asp Arg Gly Trp Asp Ile Glu Asn Leu Tyr 
        35                  40                  45              


Asp Pro Asp Pro Asp Ala Pro Gly Thr Gly Tyr Arg Val Gln Gly Gly 
    50                  55                  60                  


Phe Leu Asp Arg Ala Ala Glu Phe Asp Ala Ser Phe Phe Gly Ile Ser 
65                  70                  75                  80  


Pro Arg Glu Ala Leu Ala Met Asp Pro Gln Gln Arg Leu Val Leu Glu 
                85                  90                  95      


Thr Ser Trp Glu Ala Phe Glu Arg Ala Gly Ile Glu Pro Gly Ser Val 
            100                 105                 110         


Arg Gly Ser Asp Thr Gly Val Phe Met Gly Ala Phe Ser Ser Gly Tyr 
        115                 120                 125             


Gly Thr Gly Ala Asp Phe Gly Ala Phe Gly Ala Thr Ser Ala Ala Val 
    130                 135                 140                 


Ser Val Leu Ser Gly Arg Val Ser Tyr Phe Phe Gly Leu Glu Gly Pro 
145                 150                 155                 160 


Ala Met Thr Val Asp Thr Ala Cys Ser Ser Ser Leu Val Ala Leu His 
                165                 170                 175     


Gln Ala Gly Ser Ala Leu Arg Gln Gly Glu Cys Ser Leu Ala Leu Val 
            180                 185                 190         


Gly Gly Val Thr Val Met Ser Thr Pro Leu Thr Phe Ala Glu Phe Ala 
        195                 200                 205             


Arg Gln Arg Gly Leu Ala Ala Asp Gly Arg Ser Lys Ala Phe Ala Asp 
    210                 215                 220                 


Ala Ala Asp Gly Ala Gly Phe Ser Glu Gly Val Gly Val Leu Val Val 
225                 230                 235                 240 


Glu Arg Leu Ser Asp Ala Arg Ala Lys Gly His Arg Val Leu Ala Val 
                245                 250                 255     


Val Arg Gly Ser Ala Val Asn Gln Asp Gly Ala Ser Asn Gly Leu Ser 
            260                 265                 270         


Ala Pro Asn Gly Pro Ser Gln Gln Arg Val Ile Arg Gln Ala Leu Ala 
        275                 280                 285             


Asn Ala Gly Leu Ser Ser Ala Asp Val Asp Val Val Glu Ala His Gly 
    290                 295                 300                 


Thr Gly Thr Arg Leu Gly Asp Pro Ile Glu Ala Gln Ala Val Leu Ala 
305                 310                 315                 320 


Thr Tyr Gly Gln Asp Arg Glu Gln Pro Leu Leu Leu Gly Ser Leu Lys 
                325                 330                 335     


Ser Asn Ile Gly His Thr Gln Ala Ala Ala Gly Val Ser Gly Val Ile 
            340                 345                 350         


Lys Met Val Met Ala Leu Gln His Gly Val Val Pro Arg Thr Leu His 
        355                 360                 365             


Val Asp Ser Pro Ser Arg His Val Asp Trp Thr Ala Gly Ala Val Glu 
    370                 375                 380                 


Leu Val Thr Glu Asn Gln Pro Trp Pro Val Leu Glu Arg Ala Arg Arg 
385                 390                 395                 400 


Ala Gly Val Ser Ser Phe Gly Ile Ser Gly Thr Asn Ala His Val Ile 
                405                 410                 415     


Leu Glu Ser Ala Pro Asp Pro Asp Leu Pro Val Val Glu Val Glu Glu 
            420                 425                 430         


Thr Pro Ala Pro Val Val Ala Val Ile Ser Ala Lys Thr Pro Ser Ala 
        435                 440                 445             


Leu Val Glu Phe Glu Gly Arg Leu Arg Thr Tyr Leu Thr Ala Arg Pro 
    450                 455                 460                 


Gly Val Asp Val Arg Ala Val Ala Ser Thr Leu Ala Gly Thr Arg Ser 
465                 470                 475                 480 


Val Phe Gly His Arg Ala Val Leu Leu Gly Asp Asp Thr Val Thr Gly 
                485                 490                 495     


Thr Gly Pro Gly Ala Ala Val Ser Gly Val Val Val Ser Gly Pro Arg 
            500                 505                 510         


Val Val Phe Val Phe Pro Gly Gln Gly Trp Gln Trp Leu Gly Met Gly 
        515                 520                 525             


Cys Gly Leu Arg Glu Thr Ser Ala Val Phe Ala Gly Arg Leu Ala Glu 
    530                 535                 540                 


Cys Ala Ala Ala Leu Ser Glu Phe Val Asp Trp Asp Leu Leu Thr Val 
545                 550                 555                 560 


Leu Asp Asp Pro Ser Val Val Asp Arg Val Asp Val Leu Gln Pro Ala 
                565                 570                 575     


Cys Trp Ala Val Met Val Ser Leu Ala Ala Val Trp Gln Glu Ala Gly 
            580                 585                 590         


Val Val Pro Asp Ala Val Ile Gly His Ser Gln Gly Glu Ile Ala Ala 
        595                 600                 605             


Ala Cys Val Ala Gly Ala Leu Thr Leu Arg Asp Ala Ala Arg Ile Val 
    610                 615                 620                 


Ala Leu Arg Ser Arg Leu Ile Ala Arg Leu Ala Gly Gln Gly Ala Met 
625                 630                 635                 640 


Ala Ser Ile Ala Leu Pro Ala His Glu Ile Ala Leu Gly Asp Gly Ala 
                645                 650                 655     


Val Val Ala Ala Arg Asn Gly Pro Ala Ala Thr Val Ile Ala Gly Thr 
            660                 665                 670         


Pro Arg Ala Val Asp Arg Val Leu Ala Val His Glu Lys Gln Gly Ala 
        675                 680                 685             


Arg Val Arg Arg Ile Thr Val Asp Tyr Ala Ser His Ser Pro Gln Val 
    690                 695                 700                 


Glu Glu Ile Arg Thr Glu Leu Leu Asp Ile Leu Ala Thr Thr Gly Ser 
705                 710                 715                 720 


Arg Thr Pro Val Val Pro Trp Leu Ser Thr Val Asp Gly Thr Trp Thr 
                725                 730                 735     


Glu Gln Pro Leu Asp Pro Asp Tyr Trp Tyr Arg Asn Leu Arg Glu Pro 
            740                 745                 750         


Val Gly Phe His Pro Ala Val Asp Thr Leu Arg Ser Met Gly Glu Thr 
        755                 760                 765             


Val Phe Ile Glu Ile Ser Ala Ser Pro Thr Leu Thr Pro Ala Met Asp 
    770                 775                 780                 


Asp Ala Thr Thr Val Ala Thr Leu Arg Arg Asp Asn Asp Thr Pro Gln 
785                 790                 795                 800 


Gln Ile Leu Thr Ala Leu Ala Glu Ala His Thr His Gly Val Asn Ile 
                805                 810                 815     


His Trp Pro Thr Val Met Gly Ala Thr Thr Thr Pro Val Arg Val Asp 
            820                 825                 830         


Leu Pro Thr Tyr Ala Phe Glu Arg Gln Arg Tyr Trp Ala Trp Leu Ala 
        835                 840                 845             


Gly Leu Thr Pro Glu Glu Arg Lys Gln Ala Leu Leu Lys Thr Val Arg 
    850                 855                 860                 


Asp Ser Ala Ala Ala Val Leu Gly His Thr Asp Ala Arg Asp Ile Ala 
865                 870                 875                 880 


Met Asn Thr Ala Phe Arg Asp Leu Gly Leu Asp Ser Leu Thr Ala Val 
                885                 890                 895     


Gln Val Arg Asn Ser Leu Ala Lys Ala Thr Gly Leu Arg Leu Pro Thr 
            900                 905                 910         


Thr Thr Val Phe Asp Tyr Pro Asn Pro Thr Ala Leu Ala Thr His Leu 
        915                 920                 925             


Asp 
    


<210>  90
<211>  939
<212>  PRT
<213>  Streptomyces filamentosus

<400>  90

Glu Pro Leu Ala Ile Val Gly Met Ala Cys Arg Leu Pro Gly Gly Val 
1               5                   10                  15      


Ser Ser Pro Glu Asp Leu Trp Gln Leu Val Glu Ser Gly Thr Asp Ala 
            20                  25                  30          


Ile Ser His Phe Pro Thr Asp Arg Gly Trp Asp Ile Asp Asn Leu Tyr 
        35                  40                  45              


Asp Pro Asp Pro Asp Thr Pro Gly Lys Thr Tyr Cys Val Gln Gly Tyr 
    50                  55                  60                  


Phe Leu Asp Gly Ile Ala Glu Phe Asp Ala Ser Phe Phe Gly Ile Ser 
65                  70                  75                  80  


Pro Arg Glu Ala Gln Ala Met Asp Pro Gln Gln Arg Leu Val Leu Glu 
                85                  90                  95      


Thr Ser Trp Glu Ala Phe Glu Arg Ala Gly Ile Asp Pro Ala Ser Val 
            100                 105                 110         


Arg Gly Ser Asp Thr Gly Val Phe Met Gly Ala Phe Gly Ser Gly Tyr 
        115                 120                 125             


Gly Thr Gly Ala Asp Leu Gly Gly Phe Gly Met Thr Ala Gly Ala Gly 
    130                 135                 140                 


Ser Val Leu Ser Gly Arg Val Ser Tyr Phe Phe Gly Leu Glu Gly Pro 
145                 150                 155                 160 


Ala Met Thr Val Asp Thr Ala Cys Ser Ser Ser Leu Val Ala Leu His 
                165                 170                 175     


Gln Ala Ser Ser Ala Leu Arg Gln Gly Glu Cys Ser Leu Ala Leu Val 
            180                 185                 190         


Gly Gly Thr Thr Val Leu Ala Thr Pro Tyr Gly Leu Val Glu Ile Ser 
        195                 200                 205             


Arg Gln Arg Gly Leu Ala Ala Asp Gly Arg Ser Lys Ala Phe Ser Asp 
    210                 215                 220                 


Ala Ala Asp Gly Met Gly Phe Ser Glu Gly Val Gly Val Leu Val Val 
225                 230                 235                 240 


Glu Arg Leu Ser Asp Ala Arg Ala Lys Gly His Arg Val Leu Ala Val 
                245                 250                 255     


Val Arg Gly Ser Ala Val Asn Gln Asp Gly Ala Ser Asn Gly Leu Thr 
            260                 265                 270         


Ala Pro Asn Gly Pro Ser Gln Gln Arg Val Ile Arg Ser Ala Leu Asp 
        275                 280                 285             


Asn Ala Gly Leu Ser Ser Ala Asp Val Asp Val Val Glu Ala His Gly 
    290                 295                 300                 


Thr Gly Thr Arg Leu Gly Asp Pro Ile Glu Ala Gln Ala Val Leu Ala 
305                 310                 315                 320 


Thr Tyr Gly Gln Asp Arg Glu Gln Pro Leu Leu Leu Gly Ser Leu Lys 
                325                 330                 335     


Ser Asn Ile Gly His Thr His Ala Ala Ala Gly Val Ser Gly Val Ile 
            340                 345                 350         


Lys Met Val Met Ala Leu Gln His Gly Val Val Pro Arg Thr Leu His 
        355                 360                 365             


Val Asp Glu Pro Ser Arg His Val Asp Trp Thr Ala Gly Ala Val Glu 
    370                 375                 380                 


Leu Val Thr Glu Asn Gln Pro Trp Pro Ala Ile Asp Arg Ala Arg Arg 
385                 390                 395                 400 


Ala Gly Val Ser Ser Phe Gly Ile Ser Gly Thr Asn Ala His Val Ile 
                405                 410                 415     


Leu Glu Ser Pro Pro Ala Gln Pro Val Val Glu Val Glu Glu Thr Pro 
            420                 425                 430         


Ala Pro Pro Val Val Ala Ser Asp Met Met Pro Leu Val Ile Ser Ala 
        435                 440                 445             


Lys Thr Pro Ser Ala Leu Ala Asp Met Glu Gly Arg Leu Arg Ala Tyr 
    450                 455                 460                 


Leu Ala Ala Arg Pro Gly Val Asp Val Arg Ala Val Ala Ser Thr Leu 
465                 470                 475                 480 


Ala Gly Thr Arg Ser Val Phe Glu His Arg Ala Val Leu Leu Gly Asp 
                485                 490                 495     


Asp Thr Val Thr Gly Thr Ser Thr Gly Thr Gly Ser Gly Ala Ala Val 
            500                 505                 510         


Ser Gly Val Val Val Ser Gly Pro Arg Val Val Phe Val Phe Pro Gly 
        515                 520                 525             


Gln Gly Trp Gln Trp Leu Gly Met Gly Cys Gly Leu Arg Glu Thr Ser 
    530                 535                 540                 


Ala Val Phe Ala Gly Arg Leu Ala Glu Cys Ala Ala Ala Leu Ser Glu 
545                 550                 555                 560 


Phe Val Asp Trp Asp Leu Leu Thr Val Leu Asp Asp Pro Ser Val Val 
                565                 570                 575     


Asp Arg Val Asp Val Leu Gln Pro Ala Cys Trp Ala Val Met Val Ser 
            580                 585                 590         


Leu Ala Ala Val Trp Gln Glu Ala Gly Val Val Pro Asp Ala Val Ile 
        595                 600                 605             


Gly His Ser Gln Gly Glu Ile Ala Ala Ala Cys Val Ala Gly Ala Leu 
    610                 615                 620                 


Thr Leu Arg Asp Ala Ala Arg Ile Val Ala Leu Arg Ser Arg Leu Ile 
625                 630                 635                 640 


Ala Arg Leu Ala Gly Gln Gly Ala Met Ala Ser Ile Ala Leu Pro Ala 
                645                 650                 655     


His Glu Ile Ala Leu Gly Asp Gly Ala Val Val Ala Ala Arg Asn Gly 
            660                 665                 670         


Arg Ala Ala Thr Val Ile Ala Gly Thr Ala Arg Ala Val Asp Arg Val 
        675                 680                 685             


Leu Ala Val His Glu Lys Glu Gly Ala Arg Val Arg Arg Ile Ala Val 
    690                 695                 700                 


Asp Tyr Ala Ser His Ser Pro Gln Val Glu Glu Ile Arg Thr Glu Leu 
705                 710                 715                 720 


Leu Asp Ile Leu Ala Thr Thr Gly Ser Arg Thr Pro Val Val Pro Trp 
                725                 730                 735     


Leu Ser Thr Val Asp Gly Thr Trp Thr Glu Gln Pro Leu Asp Pro Asp 
            740                 745                 750         


Tyr Trp Tyr Arg Asn Leu Arg Glu Pro Val Gly Phe His Pro Ala Val 
        755                 760                 765             


Asp Thr Leu Arg Ser Met Gly Glu Thr Val Phe Ile Glu Ile Ser Ala 
    770                 775                 780                 


Ser Pro Thr Leu Thr Pro Ala Met Asp Asp Ala Thr Thr Val Ala Thr 
785                 790                 795                 800 


Leu Arg Arg Asp Asn Asp Thr Pro Arg Gln Ile Leu Thr Ala Leu Ala 
                805                 810                 815     


Glu Ala His Thr His Gly Val Asn Ile His Trp Pro Thr Val Ile Gly 
            820                 825                 830         


Thr Thr Thr Thr Pro Ala Arg Val Asp Leu Pro Thr Tyr Ala Phe Gln 
        835                 840                 845             


His Gln Arg Tyr Trp Thr Ser Asp Arg Leu Asn Gly Arg Thr Gly Leu 
    850                 855                 860                 


Glu Gln His Arg Val Met Leu Glu Leu Val Leu Gly His Ala Ala Ser 
865                 870                 875                 880 


Val Leu Gly His Ser Ala Pro Asp Ala Ile Ala Ala Asp Arg Pro Phe 
                885                 890                 895     


Lys Asp Leu Gly Met Asp Ser Leu Thr Ala Ile Glu Leu Arg Asn His 
            900                 905                 910         


Leu Val Ala Glu Thr Gly Leu Arg Leu Pro Ala Thr Thr Ala Phe Asp 
        915                 920                 925             


His Pro Thr Ala Asp Asp Leu Ala Lys Arg Leu 
    930                 935                 


<210>  91
<211>  962
<212>  PRT
<213>  Streptomyces filamentosus

<400>  91

Glu Pro Ile Ala Ile Val Ser Met Ala Cys Arg Val Pro Gly Gly Val 
1               5                   10                  15      


Asp Ser Pro Glu Gly Leu Trp His Leu Val Glu Ser Gly Thr Asp Ala 
            20                  25                  30          


Ile Ser Asp Phe Pro Thr Asn Arg Gly Trp Asp Val Ala Asn Leu Tyr 
        35                  40                  45              


Ser Pro Asp Pro Ala Gly Tyr Thr Ser Tyr Cys Val Gln Gly Gly Phe 
    50                  55                  60                  


Leu Asp Ser Ala Ala Asp Phe Asp Ala Thr Phe Phe Gly Ile Ser Pro 
65                  70                  75                  80  


Arg Glu Ala Leu Gly Met Asp Pro Gln Gln Arg Leu Val Leu Glu Ala 
                85                  90                  95      


Ser Trp Glu Ala Ile Glu Arg Ala Gln Ile Asp Pro Arg Ser Leu Arg 
            100                 105                 110         


Gly Ser Asn Val Gly Val Phe Val Gly Gly Ala Ser Gln Gly Tyr Gly 
        115                 120                 125             


Ala Ser Ala Asn Glu Gln Gln Gln Ser Asn Ala Ile Thr Gly Gly Ser 
    130                 135                 140                 


Ser Ser Leu Leu Ser Gly Arg Val Thr Tyr Ala Leu Gly Leu Glu Gly 
145                 150                 155                 160 


Pro Ala Val Thr Val Asp Thr Ala Cys Ser Ser Ser Leu Val Ala Leu 
                165                 170                 175     


His Leu Ala Ser Gln Ser Leu Arg Gln Arg Glu Cys Ser Leu Ala Leu 
            180                 185                 190         


Val Ser Gly Val Ser Val Met Ala Thr Pro Asp Val Phe Val Glu Phe 
        195                 200                 205             


Ser Arg Gln Arg Gly Leu Ala Pro Asp Gly Arg Cys Lys Ser Phe Ser 
    210                 215                 220                 


Ala Ser Ala Asp Gly Thr Gly Trp Ser Glu Gly Val Gly Val Leu Val 
225                 230                 235                 240 


Leu Glu Arg Leu Ser Glu Ala Thr Arg Leu Gly His Arg Val Leu Ala 
                245                 250                 255     


Val Val Arg Gly Ser Ala Val Asn Ser Asp Gly Ala Ser Asn Gly Leu 
            260                 265                 270         


Thr Ala Pro Asn Gly Ala Ser Gln Gln Arg Val Ile Arg Gln Ala Leu 
        275                 280                 285             


Ala Asn Ala Gly Leu Thr Ala Ser Gln Val Asp Ala Val Glu Ala His 
    290                 295                 300                 


Gly Thr Gly Thr Thr Leu Gly Asp Pro Ile Glu Ala Glu Ala Leu Leu 
305                 310                 315                 320 


Ala Thr Tyr Gly Gln Asp Arg Ser Thr Pro Ala Trp Leu Gly Ser Leu 
                325                 330                 335     


Lys Ser Asn Ile Gly His Thr Met Ala Ala Ser Gly Val Leu Gly Val 
            340                 345                 350         


Ile Lys Met Val Glu Ala Met Arg His Gly Leu Leu Pro Arg Thr Leu 
        355                 360                 365             


His Val Asp Glu Pro Ser Pro His Val Asp Trp Ala Ser Gly Asp Ile 
    370                 375                 380                 


Ala Leu Leu Ser Glu Ser Arg Pro Trp Pro Asp Gly Ser Thr Pro Arg 
385                 390                 395                 400 


Arg Ala Gly Val Ser Ser Phe Gly Ile Ser Gly Thr Asn Ala His Val 
                405                 410                 415     


Val Leu Glu Gln Tyr Arg Asp Pro Ala Gly Pro Asp Thr Pro Thr Gly 
            420                 425                 430         


Ser Asp Thr Gln Thr Gly Pro Glu Thr Thr Thr Glu His Gly Pro Leu 
        435                 440                 445             


Pro Leu Met Leu Ser Ala Arg Ser Pro Lys Ala Leu Arg Glu Gln Ala 
    450                 455                 460                 


Gly Arg Leu His Ala Ala Leu Val Glu Ala Pro Arg Trp Arg Pro Leu 
465                 470                 475                 480 


Asp Ile Gly Tyr Ser Leu Ala Thr Thr Arg Ser Ser Phe Ala His Arg 
                485                 490                 495     


Ala Val Ala Val Gly Ser Asp Arg Glu Leu Leu Arg Ala Leu Ser Gln 
            500                 505                 510         


Leu Ala Asp Gly Gly Thr Ser Pro Ala Leu Val Thr Ala Thr Ala Lys 
        515                 520                 525             


Ala Gly Arg Val Ala Phe Leu Phe Asp Gly Gln Gly Thr Gln Arg Leu 
    530                 535                 540                 


Gly Met Gly Ser Gly Leu Tyr Glu Arg Phe Pro Ala Phe Ala Arg Thr 
545                 550                 555                 560 


Trp Asp Leu Val Ser Ala Ala Phe Asp Lys His Leu Asn His Ser Leu 
                565                 570                 575     


Thr Asp Val Phe Leu Gly Arg Ser Gly Ser Val Thr Ala Glu Leu Val 
            580                 585                 590         


Asp Asp Thr Leu Tyr Ala Gln Ala Gly Ile Phe Thr Met Glu Val Ala 
        595                 600                 605             


Leu Phe Glu Leu Leu Asp Glu Trp Gly Ile Arg Pro Asp Phe Leu Thr 
    610                 615                 620                 


Gly His Ser Ile Gly Glu Ala Ala Ala Ala Tyr Gly Ala Gly Met Leu 
625                 630                 635                 640 


Ser Leu Glu Asp Val Thr Thr Leu Ile Val Ala Arg Gly Gln Ala Leu 
                645                 650                 655     


Arg Leu Ser Pro Pro Gly Ala Met Val Ala Leu Arg Ala Ser Glu Glu 
            660                 665                 670         


Glu Val Arg Glu Phe Leu Asp Arg Thr Gly Ala Ala Leu Asp Leu Ala 
        675                 680                 685             


Ala Val Asn Ser Pro Thr Ser Val Val Val Ser Gly Ala Pro Asp Ala 
    690                 695                 700                 


Val Ser Asp Phe Arg Thr Ala Trp Thr Glu Ser Gly Arg Glu Ala Arg 
705                 710                 715                 720 


Ala Leu Asn Val Arg His Ala Phe His Ser Arg His Val Glu Ala Gly 
                725                 730                 735     


Leu Gly Arg Phe Arg Glu Val Leu Asp Ser Leu Thr Phe Arg Ala Pro 
            740                 745                 750         


Val Leu Pro Val Val Ser Thr Val Thr Gly Arg Leu Val Glu Pro Ala 
        755                 760                 765             


Glu Met Ser Thr Pro Glu Tyr Trp Leu Arg Gln Val Arg Gln Thr Val 
    770                 775                 780                 


Arg Phe His Asp Ala Leu Arg Glu Leu Ser Gly Arg Gly Val Gly Thr 
785                 790                 795                 800 


Phe Val Glu Ile Gly Pro Ser Gly Thr Leu Ala Ser Ala Gly Leu Glu 
                805                 810                 815     


Cys Leu Gly Gly Asp Ala Ala Phe His Ala Val Gln Arg Pro Arg Ser 
            820                 825                 830         


Ala Glu Asp Val Cys Leu Met Thr Ala Val Ala Glu Leu His Ala Gly 
        835                 840                 845             


Gly Thr Ala Val Asp Trp Thr Lys Val Leu Ala Gly Gly Arg Arg Thr 
    850                 855                 860                 


Asp Leu Pro Val Tyr Pro Phe Gln His Glu Ala Tyr Trp Leu Thr Pro 
865                 870                 875                 880 


Ala Glu Pro Ser Tyr Ala Glu Glu Pro Leu Thr Thr Leu Glu Leu Val 
                885                 890                 895     


Cys Ser Glu Ala Ala Asn Val Leu Gly Ile Thr Glu Pro Gly Ile Leu 
            900                 905                 910         


Leu Glu Asp Ser Ser Phe Leu Asp Leu Gly Leu Asp Ser Leu Gly Ala 
        915                 920                 925             


Met Arg Leu Arg Asn Arg Leu Ser Glu Leu Thr Glu Leu Asp Leu Pro 
    930                 935                 940                 


Ala Thr Leu Leu Phe Asp Asn Pro Asn Pro Thr Asp Leu Ala Ala Tyr 
945                 950                 955                 960 


Leu Asp 
        


<210>  92
<211>  889
<212>  PRT
<213>  Micromonospora sp.

<400>  92

Glu Pro Leu Ala Ile Val Gly Met Ala Ala Arg Phe Pro Gly Gly Val 
1               5                   10                  15      


Ala Ser Ala Asp Asp Leu Trp Arg Leu Val Val Ser Gly Gly Asp Ala 
            20                  25                  30          


Ile Gly Gly Phe Pro Thr Asp Arg Gly Trp Asp Leu Asp Glu Leu Tyr 
        35                  40                  45              


Asp Pro Asp Pro Ala Ala Thr Gly Arg Ser Tyr Val Arg Glu Gly Gly 
    50                  55                  60                  


Phe Leu Ser Asp Ala Thr Thr Phe Asp Ala Ser Phe Phe Arg Ile Gly 
65                  70                  75                  80  


Pro Arg Glu Ala Lys Ala Met Asp Pro Gln Gln Arg Leu Leu Leu Glu 
                85                  90                  95      


Thr Ser Trp Glu Ala Phe Glu His Ala Gly Ile Arg Pro Glu Thr Leu 
            100                 105                 110         


Arg Gly Thr Ala Thr Ala Val Phe Ala Gly Ile Ser Leu Gln Asp Tyr 
        115                 120                 125             


Gly Val Leu Ala Gly Ser Asp Pro Glu Leu Glu Gly Tyr Ala Gly Thr 
    130                 135                 140                 


Gly Asn Ala Pro Ser Val Leu Ser Gly Arg Leu Ser Tyr Phe Tyr Gly 
145                 150                 155                 160 


Leu Glu Gly Pro Ala Val Thr Ile Asp Thr Ala Cys Ser Ser Ser Leu 
                165                 170                 175     


Val Ala Leu His Leu Ala Gly Gln Ser Leu Arg Arg Asp Glu Cys Thr 
            180                 185                 190         


Leu Ala Val Val Gly Gly Val Thr Val Met Pro Ser Pro Asn Val Phe 
        195                 200                 205             


Val Glu Phe Ser Arg Gln Arg Gly Leu Ala Pro Asp Gly Arg Cys Lys 
    210                 215                 220                 


Pro Phe Ala Ala Ala Ala Asp Gly Thr Gly Trp Ser Glu Gly Ala Gly 
225                 230                 235                 240 


Val Leu Val Val Glu Arg Leu Ser Asp Ala Arg Arg Asn Asn Arg Arg 
                245                 250                 255     


Ile Leu Ala Val Val Arg Gly Ser Ala Val Asn Gln Asp Gly Ala Ser 
            260                 265                 270         


Ser Gly Leu Thr Ala Pro His Gly Pro Ser Gln Gln Arg Val Ile Arg 
        275                 280                 285             


Ala Ala Leu Ala Ala Ala Gly Leu Thr Ala Gly Asp Val Asp Val Val 
    290                 295                 300                 


Glu Ala His Gly Thr Gly Thr Thr Leu Gly Asp Pro Ile Glu Ala Gln 
305                 310                 315                 320 


Gly Val Leu Ala Thr Tyr Gly Asp Arg Lys Gly Ala Pro Val Arg Leu 
                325                 330                 335     


Gly Ser Val Lys Ser Asn Leu Gly His Thr Gln Ala Ala Ala Gly Val 
            340                 345                 350         


Ala Gly Val Ile Lys Met Val Gln Ala Leu Arg His Gly Val Met Pro 
        355                 360                 365             


Arg Ser Leu His Ile Asp Glu Pro Ser Pro His Val Asp Trp Thr Ala 
    370                 375                 380                 


Gly Arg Val Glu Leu Leu Thr Ser Asn Leu Pro Trp Pro Ala Ser Glu 
385                 390                 395                 400 


Arg Pro Arg Arg Ala Ala Val Ser Ser Phe Gly Ile Ser Gly Thr Asn 
                405                 410                 415     


Ala His Val Ile Leu Glu Gln Ala Phe Pro Ala Thr Glu Pro Glu Pro 
            420                 425                 430         


Pro Phe Thr Pro Val Val Ser Gly Pro Glu Leu Pro Leu Ile Phe Ser 
        435                 440                 445             


Ala Lys Asp Pro Asp Ala Leu Ala Ala Gln Thr Arg Val Thr Asp Gly 
    450                 455                 460                 


Pro Gly Val Ala Tyr Ala Leu Ala Thr Ser Arg Ser Met Phe Asp His 
465                 470                 475                 480 


Arg Thr Val Arg Leu Gly Asp Met Thr Val Thr Gly Ile Ala Val Thr 
                485                 490                 495     


Asp Pro Glu Val Val Phe Val Phe Pro Gly Gln Gly Thr Gln Trp Ala 
            500                 505                 510         


Gly Met Gly Arg Asp Leu Met Glu Ala Ser Pro Val Phe Ala Glu Arg 
        515                 520                 525             


Met Asn Glu Cys Ala Ala Ala Leu Glu Pro Tyr Leu Asp Leu Trp Ala 
    530                 535                 540                 


Ala Ile Asp Ala Pro Asp His Val Glu Thr Leu Gln Pro Ala Ser Trp 
545                 550                 555                 560 


Ala Met Met Val Ser Leu Ala Ala Val Trp Gln Ala Ala Gly Val Gln 
                565                 570                 575     


Pro Ala Ala Val Ile Gly His Ser Gln Gly Glu Ile Ala Ala Ala Cys 
            580                 585                 590         


Val Ser Gly Ala Ile Ser Leu Gln Asp Ala Ala Ala Val Val Ala Leu 
        595                 600                 605             


Arg Ser Lys Ala Ile Ala Ala Ser Leu Gly Lys Gly Ala Met Ala Ser 
    610                 615                 620                 


Ile Pro Leu Pro Ala Asp Ala Ile Glu Leu Thr Gly Glu Val Trp Val 
625                 630                 635                 640 


Ala Ala Leu Asn Gly Pro Ser Ser Thr Val Val Ala Gly Val Pro Glu 
                645                 650                 655     


Ala Val Glu Leu Val Arg Ala Arg Tyr Glu Gly Arg Arg Ile Ala Val 
            660                 665                 670         


Asp Tyr Ala Ser His Thr Pro His Val Glu Ala Leu Arg Gly Gln Val 
        675                 680                 685             


Val Ser Val Pro Ser Gln Ala Pro Val Ile Pro Trp Phe Ser Thr Val 
    690                 695                 700                 


Asp Ser Gly Trp Val Glu Gly Pro Leu Asp Asp Asp Tyr Trp Phe Arg 
705                 710                 715                 720 


Asn Leu Arg Gln Pro Val Gln Phe Gly Pro Ala Ala Ala Gly Phe Asp 
                725                 730                 735     


Asn Ala Val Phe Ile Glu Val Ser Ala Arg Pro Val Leu Ile Pro Ala 
            740                 745                 750         


Leu Glu Ala Ser Val Thr Val Pro Ser Leu Arg Arg Asp Asp Gly Gly 
        755                 760                 765             


Pro Glu Arg Met Leu Ala Ser Leu Ala Gln Ala Phe Val Ala Gly Val 
    770                 775                 780                 


Pro Val Asp Trp Thr Thr Ile Val Ala Pro Ala Pro Phe Val Glu Leu 
785                 790                 795                 800 


Pro Thr Tyr Pro Phe Gln Gly Glu Arg Tyr Trp Ile Asp Pro Arg Thr 
                805                 810                 815     


Leu Asp Glu Val Leu Ala Val Val Arg Asp Ser Ala Ala Thr Val Leu 
            820                 825                 830         


Gly His Thr Asp Pro Thr Ala Ile Thr Pro Asp Arg Ser Phe Lys Asp 
        835                 840                 845             


Leu Gly Phe Asp Ser Leu Ala Ala Val Gln Leu Arg Asn His Leu Leu 
    850                 855                 860                 


Thr Ala Thr Gly Val Arg Leu Ser Ala Thr Ala Val Phe Asp Phe Pro 
865                 870                 875                 880 


Thr Pro Val Val Leu Ala Gly Glu Val 
                885                 


<210>  93
<211>  856
<212>  PRT
<213>  Micromonospora sp.

<400>  93

Glu Pro Ile Ala Val Val Gly Met Ala Cys Arg Leu Pro Gly Asp Val 
1               5                   10                  15      


Ser Ser Pro Glu Asp Leu Trp Arg Leu Val Ser Glu Gly Arg Asp Ala 
            20                  25                  30          


Val Gly Pro Phe Pro Ala Asp Arg Gly Trp Glu Pro Gly Asp Ala Ala 
        35                  40                  45              


Tyr Ala Arg Val Gly Gly Phe Val Thr Gly Ala Thr Gly Phe Asp Ala 
    50                  55                  60                  


Gly Phe Phe Gly Ile Ser Pro Arg Glu Ala Gln Ala Met Asp Pro Gln 
65                  70                  75                  80  


Gln Arg Leu Leu Leu Glu Val Ala Trp Glu Ala Phe Glu Arg Ala Gly 
                85                  90                  95      


Ile Ala Pro Asp Glu Leu Arg Gly Ser Asp Thr Gly Val Phe Val Gly 
            100                 105                 110         


Thr Tyr Gly Gln Gly Tyr Gly Glu Leu Ala Val Asp Gly Asp Ala Glu 
        115                 120                 125             


Gly Tyr Val Gly Ile Gly Asn Ser Gly Ser Val Val Ser Gly Arg Val 
    130                 135                 140                 


Ser Tyr Phe Phe Gly Leu Glu Gly Pro Ala Val Thr Val Asp Thr Ala 
145                 150                 155                 160 


Cys Ser Ser Ser Leu Val Ala Leu His Gln Ala Ala Gln Ala Leu Arg 
                165                 170                 175     


Gln Gly Glu Cys Ser Leu Ala Leu Val Gly Gly Val Thr Val Met Ser 
            180                 185                 190         


Ser Pro Leu Ile Phe Gln Glu Phe Ala Arg Gln Gly Gly Leu Ala Ala 
        195                 200                 205             


Asp Gly Arg Cys Lys Ala Phe Ala Asp Gly Ala Asp Gly Thr Gly Trp 
    210                 215                 220                 


Gly Glu Gly Val Gly Val Leu Val Val Glu Arg Leu Ser Glu Ala Gln 
225                 230                 235                 240 


Arg Arg Gly His Thr Val Leu Ala Val Val Arg Gly Ser Ala Val Asn 
                245                 250                 255     


Gln Asp Gly Ala Ser Asn Gly Leu Thr Ala Pro Asn Gly Pro Ser Gln 
            260                 265                 270         


Gln Arg Val Ile Arg Ala Ala Leu Ala Ser Ala Gly Leu Gly Val Gly 
        275                 280                 285             


Asp Val Asp Leu Val Glu Ala His Gly Thr Gly Thr Ala Leu Gly Asp 
    290                 295                 300                 


Pro Ile Glu Ala Gln Ala Leu Leu Ala Thr Tyr Gly Ser Asp Gly Ser 
305                 310                 315                 320 


Pro Val Trp Leu Gly Ser Leu Lys Ser Asn Ile Gly His Thr Gln Ala 
                325                 330                 335     


Ala Ala Gly Val Ala Gly Val Ile Lys Ala Val Glu Ala Met Arg His 
            340                 345                 350         


Gly Val Met Pro Arg Thr Leu His Val Asp Gln Pro Ser Ser His Val 
        355                 360                 365             


Asp Trp Ser Ala Gly Ala Val Glu Leu Leu Thr Ala Asn Arg Pro Trp 
    370                 375                 380                 


Asp Ser Gly Gly Arg Pro Arg Arg Ala Ala Val Ser Ser Phe Gly Ile 
385                 390                 395                 400 


Ser Gly Thr Asn Ala His Val Ile Leu Glu Glu Ser Pro Ser Ala Pro 
                405                 410                 415     


Val Pro Pro Glu Pro Gly Thr Ala Pro Leu Leu Leu Ser Ala Arg Ser 
            420                 425                 430         


Pro Ala Ala Leu Ala Gln Phe Glu Ser Arg Thr Ala Gly Leu Arg Pro 
        435                 440                 445             


Ser Arg Asp Leu Ala Ser Thr Leu Ser Arg Arg Ala Leu Phe Asp His 
    450                 455                 460                 


Arg Ala Val Val Leu Pro Asp Gly Asp Thr Val Arg Gly Gly Val Gly 
465                 470                 475                 480 


Asp Ala Pro Leu Val Phe Val Phe Ala Gly Gln Gly Ser Gln Arg Ala 
                485                 490                 495     


Asp Met Gly Ser Arg Leu Ala Glu Glu Phe Pro Val Phe Ala Ala Ala 
            500                 505                 510         


Tyr Glu Arg Val Trp Ser Leu Leu Asp Val Asp Glu Ser Leu Glu Val 
        515                 520                 525             


Asp His Thr Gly Phe Ala Gln Pro Ala Leu Phe Ala Phe Glu Val Ala 
    530                 535                 540                 


Leu Ala Glu Leu Leu Gly Val Arg Pro Asp Ala Val Ile Gly His Ser 
545                 550                 555                 560 


Val Gly Glu Leu Ala Ala Ala Tyr Val Ala Gly Ala Met Ser Leu Glu 
                565                 570                 575     


Asp Ala Cys Arg Leu Val Ser Ala Arg Ala Arg Leu Met Gln Ala Leu 
            580                 585                 590         


Pro Ser Gly Gly Val Met Val Ser Val Arg Val Ser Glu Glu Ala Ala 
        595                 600                 605             


Arg Thr Val Leu Arg Asp Gly Val Glu Ile Ala Ala Val Asn Gly Pro 
    610                 615                 620                 


Gln Ala Val Val Leu Ser Gly Asp Glu Asp Ala Val Leu Ala Ala Ala 
625                 630                 635                 640 


Ala Glu Leu Gly Glu Phe Lys Arg Leu Arg Thr Ser His Ala Phe His 
                645                 650                 655     


Ser Ala Arg Met Glu Pro Met Leu Glu Glu Phe Arg Ala Val Ala Ser 
            660                 665                 670         


Thr Val Ala Phe Asp Glu Pro Gln Ile Ala Leu Ser Phe Val Pro Ser 
        675                 680                 685             


Ala Glu Tyr Phe Val Arg Gln Val Arg Glu Thr Val Arg Phe Gly Glu 
    690                 695                 700                 


Gln Val Ala Ala Phe Ala Pro Gly Thr Leu Phe Val Glu Val Gly Pro 
705                 710                 715                 720 


Asp Gly Ser Leu Ser Arg Leu Thr Gly Gly Val Ser Ala Ala Glu Pro 
                725                 730                 735     


Met Lys Ala Leu Ala Tyr Leu Trp Val Arg Gly Val Gly Val Asp Trp 
            740                 745                 750         


Thr Pro Tyr Ile Gly Asp Gly Arg Leu Asp Asp Ala Pro Thr Tyr Pro 
        755                 760                 765             


Phe Gln Pro Glu Arg Tyr Trp Pro Glu Gln Arg Arg Arg Ala Arg His 
    770                 775                 780                 


Gly Asp Phe Leu Ala Leu Val Thr Ala Thr Ala Ala Val Val Leu Gly 
785                 790                 795                 800 


His Pro Glu Gly Thr Asp Ile Pro Ala Asp Thr Pro Phe Gln Ser Leu 
                805                 810                 815     


Gly Leu Asp Ser Leu Ser Ala Val Asp Leu Arg Asn Gln Leu Ala Gln 
            820                 825                 830         


Ala Thr Gly Val Arg Leu Ser Pro Thr Ala Val Phe Asp Tyr Pro Thr 
        835                 840                 845             


Pro Arg Ala Leu Ala Glu Arg Leu 
    850                 855     


<210>  94
<211>  899
<212>  PRT
<213>  Micromonospora sp.

<400>  94

Asp Pro Ile Ala Ile Val Gly Met Ala Cys Arg Tyr Pro Gly Gly Val 
1               5                   10                  15      


Ala Thr Ala Asp Asp Leu Trp Asp Leu Val Ala Glu Gly Gly Asp Ala 
            20                  25                  30          


Val Gly Pro Phe Pro Val Asp Arg Gly Trp Asp Leu Ala Ala Leu Tyr 
        35                  40                  45              


Asp Pro Asp Pro Glu Ala Ala Gly Lys Ser Tyr Val Arg Glu Gly Gly 
    50                  55                  60                  


Phe Leu Gly Gly Ala Ala Asp Phe Asp Ala Ala Phe Phe Gly Ile Ser 
65                  70                  75                  80  


Pro Arg Glu Ala Leu Ala Met Asp Pro Gln Gln Arg Leu Leu Leu Glu 
                85                  90                  95      


Thr Ala Trp Glu Ala Phe Glu His Ala Gly Ile Asp Pro Leu Asp Leu 
            100                 105                 110         


Arg Arg Ser Asp Thr Gly Val Phe Val Gly Thr Met Ala Gln Glu Tyr 
        115                 120                 125             


Gly Gly Leu Val Thr Asp Ser Ala His Gly Leu Glu Gly Trp Ile Gly 
    130                 135                 140                 


Thr Gly Asn Ser Gln Ser Val Met Ser Gly Arg Leu Ser Tyr Phe Phe 
145                 150                 155                 160 


Gly Leu Gln Gly Pro Ala Val Thr Val Asp Thr Ala Cys Ser Ser Ser 
                165                 170                 175     


Leu Val Ala Leu His Gln Ala Ala Gln Ala Leu Arg Asn Gly Glu Cys 
            180                 185                 190         


Ala Leu Ala Val Val Gly Gly Val Thr Val Met Ser Ser Pro Arg Thr 
        195                 200                 205             


Phe Gln Glu Phe Ser Arg Gln Arg Gly Met Ala Pro Asp Gly Arg Cys 
    210                 215                 220                 


Lys Pro Phe Ala Ala Ala Ala Asp Gly Thr Gly Trp Ser Glu Gly Val 
225                 230                 235                 240 


Gly Val Leu Val Val Glu Arg Leu Ser Glu Ala Arg Arg Asn Gly His 
                245                 250                 255     


Ala Val Leu Ala Val Val Arg Gly Thr Ala Val Asn Gln Asp Gly Thr 
            260                 265                 270         


Ser Asn Gly Leu Thr Ala Pro Asn Gly Pro Ala Gln Gln Gln Val Ile 
        275                 280                 285             


Arg Ala Ala Leu Glu Arg Ala Gly Leu Gly Val Gly Asp Val Asp Val 
    290                 295                 300                 


Val Glu Ala His Gly Thr Gly Thr Ala Leu Gly Asp Pro Ile Glu Ala 
305                 310                 315                 320 


Gln Ala Ile Leu Asp Thr Tyr Gly Ser Arg Thr Gly Gly Glu Pro Val 
                325                 330                 335     


Arg Leu Gly Ser Val Lys Ser Asn Leu Gly His Thr Gln Ala Ala Ala 
            340                 345                 350         


Gly Val Ala Gly Val Ile Lys Met Val Gln Ala Met Arg His Ala Thr 
        355                 360                 365             


Met Pro Arg Ser Leu His Ile Asp Glu Pro Ser Pro His Val Asp Trp 
    370                 375                 380                 


Ala Ser Gly Ala Val Glu Leu Leu Thr Ala Glu Arg Gly Trp Pro Ala 
385                 390                 395                 400 


Thr Asp Arg Pro Arg Arg Ala Ala Val Ser Ser Phe Gly Ile Ser Gly 
                405                 410                 415     


Thr Asn Ala His Val Ile Val Glu Gly Val Ala Asp Pro Glu Leu Ser 
            420                 425                 430         


Arg Glu Ala Ser Pro Gly Gly Pro Leu Pro Phe Val Leu Ser Ala Pro 
        435                 440                 445             


Thr Ala Glu Ala Leu Ser Ala Gln Glu Thr Arg Leu Arg Arg Phe Arg 
    450                 455                 460                 


Val Glu Arg Pro Asp Val Asp Glu Arg Asp Ile Ala Ile Thr Leu Ala 
465                 470                 475                 480 


Gly Arg Thr Gly Phe Ala His Arg Thr Val Leu Ile Gly Asp Leu Thr 
                485                 490                 495     


Val Ser Gly Val Ala Val Ala Asp Arg Arg Val Val Phe Val Phe Pro 
            500                 505                 510         


Gly Gln Gly Thr Gln Trp Ala Gly Met Gly Arg Asp Leu Met Ala Ala 
        515                 520                 525             


Ser Pro Val Phe Ala Glu Arg Met Asn Glu Cys Ala Ala Ala Leu Glu 
    530                 535                 540                 


Pro Tyr Leu Asp Leu Trp Glu Ala Ile Asp Ser Pro Asp Arg Val Glu 
545                 550                 555                 560 


Thr Leu Gln Pro Ala Ser Trp Ala Val Met Val Ser Leu Ala Ala Val 
                565                 570                 575     


Trp Gln Ala Ala Gly Val Gln Pro Ala Ala Val Ile Gly His Ser Gln 
            580                 585                 590         


Gly Glu Ile Ala Ala Ala Cys Val Ser Gly Ala Ile Ser Leu Gln Asp 
        595                 600                 605             


Ala Ala Ala Val Val Ala Leu Arg Ser Lys Ala Ile Gly Ala Ser Leu 
    610                 615                 620                 


Gly Lys Gly Ala Met Ala Ser Ile Pro Leu Pro Ala Asp Ala Ile Glu 
625                 630                 635                 640 


Leu Ile Asp Glu Val Trp Ile Ala Ala Leu Asn Gly Pro Ser Ser Thr 
                645                 650                 655     


Val Val Ala Gly Ala Pro Glu Ala Val Glu Gln Ile Arg Ala Arg Tyr 
            660                 665                 670         


Asp Gly Arg Arg Ile Ala Val Asp Tyr Ala Ser His Thr Pro His Val 
        675                 680                 685             


Glu Ala Leu Arg Gly Gln Val Val Ser Val Pro Ser Arg Ala Pro Ala 
    690                 695                 700                 


Ile Pro Trp Phe Ser Thr Val Asp Ser Ala Trp Val Glu Asp Pro Leu 
705                 710                 715                 720 


Asp Glu Asp Tyr Trp Phe Arg Asn Leu Arg Gln Pro Val Gln Phe Gly 
                725                 730                 735     


Pro Ala Ala Ala Gly Phe Asp Asn Ala Val Phe Ile Glu Val Ser Ala 
            740                 745                 750         


Arg Pro Val Leu Ile Pro Ala Leu Glu Asp Ala Val Thr Val Pro Thr 
        755                 760                 765             


Leu Arg Arg Asp Asp Gly Gly Ile Asp Arg Leu His Ala Ser Val Ala 
    770                 775                 780                 


Gln Ala Trp Thr Ala Gly Ala Asp Val Asp Trp Ala Ala Leu Leu Pro 
785                 790                 795                 800 


Ala Gly Gly Arg Arg Ile Ala Leu Pro Pro Tyr Ala Phe Thr His Glu 
                805                 810                 815     


Arg Phe Trp Pro Arg Arg Pro Thr Ala Ala Gly Gln Asp Leu Leu Thr 
            820                 825                 830         


Val Val Arg Thr Ala Ala Ala Thr Val Leu Gly His Arg Asp Ala Ala 
        835                 840                 845             


Arg Val Pro Ala Asp Arg Ala Phe Lys Glu Leu Gly Phe Asp Ser Leu 
    850                 855                 860                 


Ser Ala Val Gln Leu Arg Asn Glu Leu Leu Thr Ala Thr Gly Val Arg 
865                 870                 875                 880 


Leu Ser Ala Thr Ala Val Phe Asp His Pro Thr Ala Ala Ala Leu Ala 
                885                 890                 895     


Glu Ala Leu 
            


<210>  95
<211>  872
<212>  PRT
<213>  Micromonospora sp.

<400>  95

Glu Pro Ile Ala Ile Val Gly Met Ala Cys Arg Leu Pro Gly Asp Val 
1               5                   10                  15      


Ser Ser Pro Asp Glu Leu Trp Glu Leu Val Glu Ala Gly Arg Asp Ala 
            20                  25                  30          


Val Gly Pro Phe Pro Ala Asp Arg Gly Trp Asn Leu Ser Thr Leu Phe 
        35                  40                  45              


Asp Pro Asp Pro Asp Ala Pro Gly Lys Ser Tyr Val Arg Glu Gly Gly 
    50                  55                  60                  


Phe Leu Thr Gly Ala Gly Leu Phe Asp Ala Asp Phe Phe Gly Ile Ser 
65                  70                  75                  80  


Pro Arg Glu Ala Leu Ala Met Asp Pro Gln Gln Arg Leu Leu Leu Glu 
                85                  90                  95      


Met Ala Trp Glu Ala Phe Glu Arg Ala Gly Ile Ala Pro Asp Glu Leu 
            100                 105                 110         


Arg Gly Ser Asp Thr Gly Val Tyr Val Gly Thr Tyr Ala Gln Gly Tyr 
        115                 120                 125             


Gly Glu Leu Ala Ala Ala Thr Ala Gly Glu Gly Phe Val Gly Ile Gly 
    130                 135                 140                 


Asn Ser Gly Ser Val Val Ser Gly Arg Val Ser Tyr Phe Leu Gly Leu 
145                 150                 155                 160 


Glu Gly Pro Ala Val Thr Val Asp Thr Ala Cys Ser Ser Ser Leu Val 
                165                 170                 175     


Ala Leu His Gln Ala Ala Gln Ala Leu Arg Leu Gly Glu Cys Ser Met 
            180                 185                 190         


Ala Leu Val Gly Gly Val Thr Val Met Ala Ser Pro Leu Met Phe Gln 
        195                 200                 205             


Glu Phe Ser Arg Gln Arg Gly Leu Ser Pro Asp Gly Arg Cys Lys Ala 
    210                 215                 220                 


Phe Ala Glu Ser Ala Asp Gly Thr Gly Trp Gly Glu Gly Val Gly Val 
225                 230                 235                 240 


Leu Val Val Glu Arg Leu Ser Glu Ala Arg Arg Arg Gly His Thr Val 
                245                 250                 255     


Leu Ala Val Val Arg Gly Ser Ala Val Asn Gln Asp Gly Ala Ser Asn 
            260                 265                 270         


Gly Leu Thr Ala Pro Asn Gly Pro Ser Gln Gln Arg Val Ile Arg Ala 
        275                 280                 285             


Ala Leu Ala Ser Ala Gly Leu Thr Val Gly Asp Val Asp Leu Val Glu 
    290                 295                 300                 


Gly His Gly Thr Gly Thr Ala Leu Gly Asp Pro Ile Glu Ala Gln Ala 
305                 310                 315                 320 


Leu Leu Ala Thr Tyr Gly Ser Ala Gly Ser Pro Val Trp Leu Gly Ser 
                325                 330                 335     


Leu Lys Ser Asn Ile Gly His Thr Gln Ala Ala Ala Gly Val Ala Gly 
            340                 345                 350         


Val Ile Lys Met Val Gln Ala Met Arg His Gly Val Met Pro Arg Thr 
        355                 360                 365             


Leu His Val Asp Gln Pro Ser Ser His Val Asp Trp Ser Ala Gly Ala 
    370                 375                 380                 


Val Glu Leu Leu Thr Ala Asn Arg Pro Trp Asp Ser Gly Gly Arg Pro 
385                 390                 395                 400 


Arg Arg Ala Ala Val Ser Ser Phe Gly Ile Ser Gly Thr Asn Ala His 
                405                 410                 415     


Val Ile Leu Glu Gly Val Pro Ala Pro Glu Pro Ala Ala Gly Asp Ala 
            420                 425                 430         


Glu Thr Ala Pro Leu Val Leu Ser Ala Arg Thr Ala Pro Ala Leu Thr 
        435                 440                 445             


Asp Leu Glu Ala Arg Val Ser Ala Arg Pro Ser Ser Pro Asp Leu Ala 
    450                 455                 460                 


Ala Thr Leu Ala Gly Arg Ala Ser Phe Asp His Arg Ala Val Val Leu 
465                 470                 475                 480 


Pro Asp Gly Glu Val Val Arg Gly Arg Ala Gly Ala Ala Pro Val Val 
                485                 490                 495     


Leu Val Phe Ala Gly Gln Gly Ser Gln Arg Ala Asp Met Ala Ser Arg 
            500                 505                 510         


Leu Ala Gly Glu Phe Pro Val Phe Ala Ala Ala Tyr Glu Arg Val Trp 
        515                 520                 525             


Ser Leu Leu Asp Val Asp Glu Ala Leu Asp Thr Asp Gln Thr Gly Phe 
    530                 535                 540                 


Ala Gln Pro Ala Leu Phe Ala Tyr Glu Val Ala Leu Ala Glu Leu Leu 
545                 550                 555                 560 


Asn Val Arg Pro Asp Ala Val Ile Gly His Ser Ile Gly Glu Leu Ala 
                565                 570                 575     


Ala Ala Tyr Thr Ser Gly Ser Leu Ser Leu Glu Asp Ala Cys Arg Leu 
            580                 585                 590         


Val Ser Ala Arg Ala Arg Leu Met Gln Ala Leu Pro Pro Gly Gly Ala 
        595                 600                 605             


Met Val Ser Val Arg Val Ser Glu Glu Val Ala Arg Glu Val Leu Arg 
    610                 615                 620                 


Asp Gly Val Glu Ile Ala Ala Val Asn Gly Pro Gln Ala Val Val Leu 
625                 630                 635                 640 


Ser Gly Asp Glu Asp Ala Val Leu Ala Ala Ala Ala Lys Leu Gly Glu 
                645                 650                 655     


Phe Lys Arg Leu Arg Thr Ser His Ala Phe His Ser Ala Arg Met Glu 
            660                 665                 670         


Pro Met Leu Glu Glu Phe Arg Ala Val Ala Leu Thr Val Glu Phe Arg 
        675                 680                 685             


Glu Pro Glu Val Ala Leu Ser Phe Val Pro Ser Ala Glu Tyr Phe Val 
    690                 695                 700                 


Gly Gln Val Arg Glu Thr Val Arg Phe Gly Glu Gln Val Ala Ser Phe 
705                 710                 715                 720 


Glu Pro Gly Thr Leu Phe Val Glu Val Gly Pro Asp Gly Ser Leu Ser 
                725                 730                 735     


Arg Leu Thr Gly Gly Val Ser Ala Ala Glu Pro Leu Thr Ala Leu Ala 
            740                 745                 750         


Tyr Leu Trp Val His Gly Val Ala Ile Asp Trp Val Pro Tyr Leu Gly 
        755                 760                 765             


Gly Gly Arg Leu Asp Leu Gly Ala Pro Thr Tyr Pro Phe Gln His Glu 
    770                 775                 780                 


Arg Tyr Trp Pro Ala Arg Ala Leu Ala Gln Leu Pro Pro Ala Arg Arg 
785                 790                 795                 800 


Gly Arg Ala Leu Leu Asp Leu Val Gln Asn Arg Val Ala Lys Thr Leu 
                805                 810                 815     


Gly Leu Val Arg Pro Ala Asp Pro Gly Arg Ala Phe Thr Asp Leu Gly 
            820                 825                 830         


Phe Thr Ser Leu Thr Ala Leu Glu Leu Arg Asn Ser Ile Ala Glu Glu 
        835                 840                 845             


Thr Gly Leu Pro Met Pro Ala Ser Leu Val Phe Asp His Pro Asn Ala 
    850                 855                 860                 


Arg Ser Leu Ala Gly Tyr Leu Asp 
865                 870         


<210>  96
<211>  896
<212>  PRT
<213>  Micromonospora sp.

<400>  96

Glu Pro Leu Ala Ile Val Gly Met Ala Cys Arg Leu Pro Gly Gly Ile 
1               5                   10                  15      


Ser Ser Ala Glu Glu Leu Trp Arg Leu Val Ala Glu Gly Gly Asp Ala 
            20                  25                  30          


Ile Gly Pro Phe Pro Gly Asp Arg Gly Trp Asp Val Asp Ala Leu Tyr 
        35                  40                  45              


Asp Pro Asp Pro Ala Ala Gly His Thr Tyr Thr Arg Ser Gly Gly Phe 
    50                  55                  60                  


Leu Pro Gly Ala Thr Asp Phe Asp Ala Ala Phe Phe Gly Ile Ser Pro 
65                  70                  75                  80  


Arg Glu Ala Gln Ala Met Asp Pro Gln His Arg Gln Leu Leu Glu Thr 
                85                  90                  95      


Ser Trp Glu Ala Leu Glu His Ala Gly Ile Asp Pro Ala Gly Leu Arg 
            100                 105                 110         


Gly Arg Asp Val Gly Val Phe Ala Gly Phe Ser Gly Gln Asp Tyr Ile 
        115                 120                 125             


Ala Glu Met Gly Val Gly Pro Ala Glu Ala Gly Gly Tyr Gln Val Thr 
    130                 135                 140                 


Gly Arg Ala Ala Ser Val Leu Ser Gly Arg Leu Ser Tyr Phe Tyr Gly 
145                 150                 155                 160 


Leu Glu Gly Pro Ala Val Thr Val Asp Thr Ala Cys Ser Ser Ser Leu 
                165                 170                 175     


Val Ala Leu His Leu Ala Gly Gln Ser Leu Arg Asp Gly Glu Ser Ser 
            180                 185                 190         


Leu Ala Leu Val Gly Gly Val Thr Val Met Ser Ser Pro Gly Leu Phe 
        195                 200                 205             


Val Glu Phe Ser Arg Gln Arg Gly Leu Ala Pro Asp Gly Arg Cys Lys 
    210                 215                 220                 


Ala Phe Ser Ala Asp Ala Asp Gly Thr Gly Trp Ser Glu Gly Val Gly 
225                 230                 235                 240 


Val Leu Val Val Glu Arg Leu Ser Asp Ala Arg Arg Asn Gly His Arg 
                245                 250                 255     


Ile Leu Ala Val Val Arg Gly Ser Ala Val Asn Gln Asp Gly Ala Ser 
            260                 265                 270         


Asn Gly Leu Thr Ala Pro Asn Gly Pro Ser Gln Gln Arg Val Ile Arg 
        275                 280                 285             


Gln Ala Leu Ala Gln Ser Gly Leu Ser Val Ala Asp Val Asp Val Val 
    290                 295                 300                 


Glu Ala His Gly Thr Gly Thr Ala Leu Gly Asp Pro Ile Glu Ala Gln 
305                 310                 315                 320 


Ala Val Leu Ala Thr Tyr Gly Gly Arg Ala Gly Gly Glu Pro Val Arg 
                325                 330                 335     


Leu Gly Ser Leu Lys Ser Asn Ile Gly His Thr Gln Ala Ala Ala Gly 
            340                 345                 350         


Ile Ala Ser Leu Ile Lys Met Val Gln Ala Ile Arg Tyr Gly Val Met 
        355                 360                 365             


Pro Arg Thr Leu His Val Ser Glu Pro Ser Pro Leu Val Asp Trp Ala 
    370                 375                 380                 


Ser Gly Arg Val Glu Leu Leu Thr Ser Asp Ile Pro Trp Pro Asp Gly 
385                 390                 395                 400 


Val Arg Arg Ala Ala Val Ser Ala Phe Gly Ile Ser Gly Thr Asn Ala 
                405                 410                 415     


His Val Ile Leu Glu Glu Ala Pro Ala Pro Ala Ala Val Pro Ser Ile 
            420                 425                 430         


Arg Pro Val Val Ser Gly Pro Ala Leu Pro Leu Val Phe Ser Ala Arg 
        435                 440                 445             


Asp Pro Ser Ala Leu Ala Ala Gln Thr Arg Val Thr Asp Gly Pro Gly 
    450                 455                 460                 


Val Ala Tyr Ala Leu Ala Thr Ser Arg Thr Met Leu Asp His Arg Thr 
465                 470                 475                 480 


Val Arg Leu Asn Asp Val Thr Val Thr Gly Ile Ala Val Thr Asp Pro 
                485                 490                 495     


Glu Val Val Phe Val Phe Pro Gly Gln Gly Ser Gln Trp Ala Gly Met 
            500                 505                 510         


Gly Arg Asp Leu Met Gly Ser Ser Pro Val Phe Ala Glu Arg Met Asn 
        515                 520                 525             


Glu Cys Ala Ala Ala Leu Glu Pro Tyr Leu Asp Leu Trp Ala Ala Ile 
    530                 535                 540                 


Asp Ala Pro Asp Arg Val Glu Thr Leu Gln Pro Ala Ser Trp Ala Val 
545                 550                 555                 560 


Met Val Ser Leu Ala Ala Val Trp Gln Ala Ala Gly Val Gln Pro Ala 
                565                 570                 575     


Ala Val Ile Gly His Ser Gln Gly Glu Ile Ala Ala Ala Cys Val Ser 
            580                 585                 590         


Gly Ala Ile Ser Leu Gln Asp Ala Ala Ala Val Val Ala Leu Arg Ser 
        595                 600                 605             


Arg Ala Ile Ala Ala Ser Leu Gly Lys Gly Ala Met Ala Ser Ile Pro 
    610                 615                 620                 


Leu Pro Ala Asp Ala Ile Glu Leu Ala Asp Glu Val Trp Val Ala Ala 
625                 630                 635                 640 


Leu Asn Gly Pro Ser Ser Thr Val Val Ala Gly Ala Leu Glu Ala Val 
                645                 650                 655     


Glu Gln Val Arg Ala Arg Tyr Glu Gly Arg Arg Ile Ala Val Asp Tyr 
            660                 665                 670         


Ala Ser His Thr Pro His Val Glu Ala Leu Arg Gly Gln Val Val Ser 
        675                 680                 685             


Val Pro Ser Gln Ala Pro Ala Ile Pro Trp Phe Ser Thr Val Asp Ser 
    690                 695                 700                 


Gly Trp Ile Glu Gly Pro Leu Asp Asp Asp Tyr Trp Phe Arg Asn Leu 
705                 710                 715                 720 


Arg Gln Gln Val Gln Phe Gly Pro Ala Ala Ala Gly Phe Asp Asn Ala 
                725                 730                 735     


Val Phe Ile Glu Val Ser Ala Arg Pro Val Leu Ile Pro Ala Leu Asp 
            740                 745                 750         


Ala Ser Val Thr Val Pro Ser Leu Arg Arg Asp Asp Gly Gly Pro Glu 
        755                 760                 765             


Arg Met Leu Ala Ser Leu Ala Gln Ala Phe Val Ala Gly Val Pro Val 
    770                 775                 780                 


Asp Trp Thr Thr Ile Val Pro Pro Ala Pro His Val Glu Leu Pro Ser 
785                 790                 795                 800 


Tyr Pro Phe Gln Arg Gln Arg His Trp Ile Asp Met Glu Arg Leu Gly 
                805                 810                 815     


Gln Leu Pro Pro Gly Asp Arg Asp Arg Phe Leu Leu Asp Leu Val Arg 
            820                 825                 830         


Asp Ala Ala Ala Ala Val Leu Gly His Gly Ser Arg Glu Thr Val Pro 
        835                 840                 845             


Ala Ser Ala Ala Phe Lys Glu Leu Gly Phe Asp Ser Leu Ile Ala Val 
    850                 855                 860                 


Gln Leu Arg Asn Ala Val Ser Ala Ala Thr Gly Val Arg Leu Pro Ala 
865                 870                 875                 880 


Thr Val Thr Phe Asp His Pro Thr Pro Gln Ala Leu Ala Ala Leu Leu 
                885                 890                 895     


<210>  97
<211>  919
<212>  PRT
<213>  Micromonospora sp.

<400>  97

Glu Pro Leu Ala Ile Val Gly Met Ala Cys Lys Phe Pro Gly Gly Val 
1               5                   10                  15      


Asp Ser Pro Glu Arg Leu Trp Glu Met Leu Glu Ala Gly Glu Asp Val 
            20                  25                  30          


Ile Gly Pro Phe Pro Asp Asp Arg Gly Trp Asp Val Asp Gly Gly Tyr 
        35                  40                  45              


Asp Pro Asp Pro Glu Lys Ala Gly Ser Trp Tyr Ala Arg Ala Gly Gly 
    50                  55                  60                  


Phe Leu Ala Gly Ala Ala Asp Phe Asp Ala Ala Phe Phe Gly Ile Asn 
65                  70                  75                  80  


Pro Arg Glu Ala Leu Ala Met Asp Pro Gln Gln Arg Leu Leu Leu Glu 
                85                  90                  95      


Val Ala Trp Glu Ala Phe Glu Arg Ser Gly Ile Ala Pro Asp Ser Leu 
            100                 105                 110         


Arg Gly Thr Asp Thr Gly Val Phe Val Gly Thr Phe Gly Gln Gly Tyr 
        115                 120                 125             


Gly Arg Leu Val Ser Ala Gly Ala Pro Gly Leu Glu Ala Tyr Ser Gly 
    130                 135                 140                 


Thr Gly Asn Thr Gly Ser Val Ala Ser Gly Arg Leu Ser Tyr Val Phe 
145                 150                 155                 160 


Gly Leu Glu Gly Pro Ala Val Thr Val Asp Thr Ala Cys Ser Ser Ser 
                165                 170                 175     


Leu Val Ala Leu His Gln Ala Ser Gln Ser Leu His Arg Gly Glu Cys 
            180                 185                 190         


Ser Leu Ala Leu Val Ala Gly Val Thr Val Met Ser Thr Pro Asp Ser 
        195                 200                 205             


Phe Val Glu Phe Ser Arg Gln Arg Gly Leu Ser Pro Asp Gly Arg Cys 
    210                 215                 220                 


Lys Ala Phe Ala Ala Ala Ala Asp Gly Thr Gly Phe Ser Glu Gly Ala 
225                 230                 235                 240 


Gly Val Leu Val Val Glu Arg Leu Ser Asp Ala Gln Arg Asn Gly His 
                245                 250                 255     


Gln Ile Leu Ala Val Val Arg Gly Ser Ala Val Asn Gln Asp Gly Ala 
            260                 265                 270         


Ser Asn Gly Leu Thr Ala Pro His Gly Pro Ser Gln Gln Arg Val Ile 
        275                 280                 285             


Asn Thr Ala Leu Thr Asp Ala Asp Leu Thr Thr Thr Asp Ile Asp Leu 
    290                 295                 300                 


Val Glu Ala His Gly Thr Gly Thr Thr Leu Gly Asp Pro Ile Glu Ala 
305                 310                 315                 320 


Gln Ala Ile Leu Ala Thr Tyr Gly Asn Arg Thr Thr Gly Asn Pro Val 
                325                 330                 335     


His Leu Gly Ser Val Lys Ser Asn Leu Gly His Thr Gln Ala Ala Ala 
            340                 345                 350         


Gly Val Ala Gly Val Ile Lys Val Ile Gln Ala Met Arg His Ala Thr 
        355                 360                 365             


Met Pro Lys Ser Leu His Ile Asp Gln Pro Ser Pro His Val Asp Trp 
    370                 375                 380                 


Thr Ala Gly Arg Val Glu Leu Leu Thr Gly Asn Arg Pro Trp Pro Ala 
385                 390                 395                 400 


Thr Asp Arg Pro Arg Arg Ala Ala Val Ser Ser Phe Gly Val Ser Gly 
                405                 410                 415     


Thr Asn Ala His Val Ile Leu Glu Glu Arg Ala Ala Ala Glu Glu Gln 
            420                 425                 430         


Pro Pro Ala Val Asp Gly Pro Val Pro Leu Val Leu Ser Ala Arg Thr 
        435                 440                 445             


Pro Glu Ala Leu Thr Ala Gln Glu Glu Ala Val Arg Gly Leu Ser Thr 
    450                 455                 460                 


Asp Asp Arg His Arg Val Ala Pro Ala Leu Ala Leu Gly Arg Ala Ala 
465                 470                 475                 480 


Leu Pro His Arg Ala Val Leu Leu Gly Asp Ser Val Ile Arg Gly Thr 
                485                 490                 495     


Ala Ser Ala Asp Asp Gly Arg Pro Val Phe Leu Phe Pro Gly Gln Gly 
            500                 505                 510         


Ala Gln Trp Ala Gly Met Gly Arg Glu Leu Met Ala Ala Ser Pro Val 
        515                 520                 525             


Phe Ala Glu Arg Met Arg Glu Cys Ala Val Ala Leu Ala Gly Phe Val 
    530                 535                 540                 


Asp Trp Asp Leu Phe Ala Val Leu Asp Asp Ala Glu Ala Leu Arg Arg 
545                 550                 555                 560 


Thr Glu Ile Val Gln Pro Ala Ser Trp Ala Val Met Val Ser Leu Ala 
                565                 570                 575     


Ala Leu Trp Glu Ser Trp Gly Val His Pro Ala Ala Val Val Gly His 
            580                 585                 590         


Ser Gln Gly Glu Thr Ala Ala Ala Val Val Ala Gly Ala Ile Gly Leu 
        595                 600                 605             


Arg Asp Gly Ala Arg Leu Ser Ala Thr Arg Ser Arg Val Leu Ala Leu 
    610                 615                 620                 


Leu Ala Gly His Gly Ala Leu Ala Ser Ile Ala Leu Pro Ala Ala Glu 
625                 630                 635                 640 


Val Glu Val Val Asp Gly Val Ser Val Ala Ala Val Asn Gly Pro Arg 
                645                 650                 655     


Ala Thr Leu Ile Ser Gly Asp Pro Ala Gly Val Glu Ala Val Thr Ala 
            660                 665                 670         


Arg Tyr Glu Ala Ser Gly Val Arg Val Arg Arg Ile Pro Ala Asp Val 
        675                 680                 685             


Ala Ser His Ser Pro His Val Glu Arg Ala Glu Glu Thr Leu Leu Thr 
    690                 695                 700                 


Ala Leu Ala Gly Ile Glu Ala Arg Val Pro Gly Val Pro Trp Leu Ser 
705                 710                 715                 720 


Thr Ala Thr Gly Asp Trp Ile Thr Glu Pro Val Asp Glu Arg Tyr Trp 
                725                 730                 735     


Tyr Arg Asn Leu Arg Ser Pro Val Leu Phe His Pro Ala Ile Thr Thr 
            740                 745                 750         


Leu Arg Asp Arg Gly His Arg Leu Phe Leu Glu Ile Ser Thr His Pro 
        755                 760                 765             


Gln Leu Leu Pro Ala Met Glu Asp Asp Leu Leu Thr Val Gly Ser Leu 
    770                 775                 780                 


Arg Arg Asp Asp Gly Gly Pro Asp Arg Met His Thr Ala Leu Ala Glu 
785                 790                 795                 800 


Ala Trp Ala Gly Gly Ala Asp Val Asp Trp Pro Ala Val Leu Gly Ala 
                805                 810                 815     


Gly Pro Val Arg Ala Leu Asp Leu Pro Thr Tyr Pro Phe Gln Arg Arg 
            820                 825                 830         


Arg Phe Trp Pro Glu Ala Ala Leu Pro Pro Val Glu Arg Asp Arg Ala 
        835                 840                 845             


Leu Val Glu Ile Val Arg Asp Gln Ala Ala Ala Val Leu Gly His Pro 
    850                 855                 860                 


Asp Ala Gly Ala Leu Thr Pro Gly Thr Ala Phe Arg Asp Leu Gly Phe 
865                 870                 875                 880 


Asp Ser Leu Thr Ala Val Gln Leu Arg Asn His Leu Ala Thr Ala Thr 
                885                 890                 895     


Gly Leu Thr Leu Pro Ala Thr Val Ile Phe Asp His Pro Thr Pro Arg 
            900                 905                 910         


Ala Leu Ala Thr Phe Leu Asp 
        915                 


<210>  98
<211>  883
<212>  PRT
<213>  Micromonospora sp.

<400>  98

Glu Pro Leu Ala Val Val Gly Met Ala Cys Arg Leu Pro Gly Gly Val 
1               5                   10                  15      


Ala Ser Pro Asp Gln Leu Trp Asp Leu Val Val Ser Gly Gly Asp Gly 
            20                  25                  30          


Ile Gly Pro Phe Pro Ala Asp Arg Gly Trp Pro Thr Asp Asp Ile Phe 
        35                  40                  45              


Asp Pro Asp Pro Asp Ala Pro Gly Lys Thr Tyr Val Arg Glu Gly Gly 
    50                  55                  60                  


Phe Leu Asp Gly Ala Gly Glu Phe Asp Ala Ala Phe Phe Gly Ile Ser 
65                  70                  75                  80  


Pro Arg Glu Ala Leu Ala Met Asp Pro Gln Gln Arg Leu Leu Leu Glu 
                85                  90                  95      


Thr Ser Trp Glu Ala Phe Glu His Ala Gly Ile Asp Pro Ala Gly Leu 
            100                 105                 110         


Arg Gly Gly Asp Thr Gly Val Phe Val Gly Gly Phe Thr Gln Ala Tyr 
        115                 120                 125             


Gly Val Gly Thr Ala Asp Leu Glu Gly Tyr Ala Ala Thr Gly Thr Val 
    130                 135                 140                 


Gly Ser Val Leu Ser Gly Arg Leu Ser Tyr Phe Tyr Gly Phe Glu Gly 
145                 150                 155                 160 


Pro Ala Val Thr Val Asp Thr Ala Cys Ser Ser Ser Leu Val Ala Leu 
                165                 170                 175     


His Gln Ala Gly Gln Ala Leu Arg Gln Gly Glu Cys Thr Leu Ala Val 
            180                 185                 190         


Val Gly Gly Val Thr Val Met Pro Thr Pro Val Val Phe Gln Glu Phe 
        195                 200                 205             


Ser Arg Gln Arg Gly Leu Ala Thr Asp Gly Arg Cys Lys Ala Phe Ala 
    210                 215                 220                 


Asp Glu Ala Asp Gly Thr Gly Phe Ala Glu Gly Ala Gly Val Leu Leu 
225                 230                 235                 240 


Val Cys Arg Leu Ser Asp Ala Arg Arg Asp Gly Arg Arg Ile Leu Ala 
                245                 250                 255     


Val Val Arg Gly Ser Ala Val Asn Gln Asp Gly Ala Ser Asn Gly Leu 
            260                 265                 270         


Thr Ala Pro His Gly Pro Ser Gln Gln Arg Val Ile Arg Ala Ala Leu 
        275                 280                 285             


Ala Asn Ala Arg Leu Gly Pro Gly Asp Val Asp Leu Ile Glu Gly His 
    290                 295                 300                 


Gly Thr Gly Thr Thr Leu Gly Asp Pro Ile Glu Ala Gln Ala Leu Leu 
305                 310                 315                 320 


Ala Thr His Gly Ser Gly Ala Ser Pro Val Arg Leu Gly Ser Leu Lys 
                325                 330                 335     


Ser Asn Ile Gly His Thr Gln Ala Ala Ala Gly Val Ala Gly Val Ile 
            340                 345                 350         


Lys Val Ile Gln Ala Leu Arg Asn Gly Leu Met Pro Arg Thr Leu His 
        355                 360                 365             


Ala Gly Thr Pro Ser Ser Arg Val Asp Trp Ser Ala Gly Asn Val Glu 
    370                 375                 380                 


Leu Leu Thr Ser Asn Leu Pro Trp Pro Ala Ala Asp Arg Pro Arg Arg 
385                 390                 395                 400 


Ala Ala Val Ser Ser Phe Gly Ile Ser Gly Thr Asn Ala His Val Ile 
                405                 410                 415     


Leu Glu Glu Ala Pro Ala Ala Ala Ala Val Pro Thr Ile Ser Pro Val 
            420                 425                 430         


Val Ser Gly Pro Ala Leu Pro Leu Val Phe Ser Ala Arg Asp Pro Ser 
        435                 440                 445             


Ala Leu Ala Ala Gln Thr Arg Val Thr Glu Gly Pro Gly Val Ala Phe 
    450                 455                 460                 


Ala Leu Ala Thr Thr Arg Ser Met Phe Glu His Arg Ala Val Arg Ile 
465                 470                 475                 480 


Gly Asp Phe Ser Val Ser Gly Ala Ala Val Ala Asp Arg Arg Val Val 
                485                 490                 495     


Phe Val Phe Pro Gly Gln Gly Thr Gln Trp Ala Gly Met Gly Arg Asp 
            500                 505                 510         


Leu Met Ser Ala Ser Pro Val Phe Ala Glu Arg Met Asn Glu Cys Ala 
        515                 520                 525             


Ala Ala Leu Glu Pro Tyr Leu Asp Leu Trp Glu Ala Ile Asp Ser Pro 
    530                 535                 540                 


Asp Arg Val Glu Thr Leu Gln Pro Ala Ser Trp Ala Val Met Val Ser 
545                 550                 555                 560 


Leu Ala Ala Val Trp Gln Ala Ala Gly Val Gln Pro Ala Ala Val Ile 
                565                 570                 575     


Gly His Ser Gln Gly Glu Ile Ala Ala Ala Cys Val Ala Gly Ser Ile 
            580                 585                 590         


Thr Leu Gln Asp Ala Ala Ala Val Val Ala Leu Arg Ser Arg Ala Ile 
        595                 600                 605             


Ala Ala Ser Leu Gly Lys Gly Ala Met Ala Ser Ile Pro Leu Pro Ala 
    610                 615                 620                 


Glu Gln Ile Glu Leu Ala Gly Glu Val Trp Val Ala Ala Leu Asn Gly 
625                 630                 635                 640 


Pro Ser Ser Thr Val Val Ala Gly Leu Pro Glu Ala Val Glu Gln Val 
                645                 650                 655     


Arg Ala Arg Tyr Glu Gly Arg Arg Ile Ala Val Asp Tyr Ala Ser His 
            660                 665                 670         


Thr Pro His Val Glu Ala Leu Arg Gly Gln Val Val Ser Val Pro Ser 
        675                 680                 685             


Arg Ala Pro Ala Ile Pro Trp Phe Ser Thr Val Asp Ser Gly Trp Ile 
    690                 695                 700                 


Glu Gly Pro Leu Asp Glu Asp Tyr Trp Phe Arg Asn Leu Arg Gln Pro 
705                 710                 715                 720 


Val Gln Phe Gly Pro Ala Ala Gly Arg Phe Asp Asp Ala Val Phe Ile 
                725                 730                 735     


Glu Val Ser Ala Arg Pro Val Leu Ile Pro Ala Leu Glu Asp Ala Ala 
            740                 745                 750         


Thr Val Pro Ser Leu Arg Arg Asp Asp Gly Gly Gly Asp Arg Met Leu 
        755                 760                 765             


Ala Ser Leu Ala Gln Ala Phe Val Ala Gly Val Pro Val Asp Trp Thr 
    770                 775                 780                 


Thr Ile Ile Pro Pro Ala Pro Phe Val Glu Leu Pro Ser Tyr Pro Phe 
785                 790                 795                 800 


Gln His Arg Arg Tyr Trp Ile Asp Ser Ser Glu Asp Ala Leu Arg Asp 
                805                 810                 815     


Leu Val Arg Glu Gln Ala Ala Ala Val Leu Gly Tyr Pro Asp Pro Ser 
            820                 825                 830         


Arg Ile Thr Pro Gly Val Ala Phe Arg Asp Leu Gly Phe Asp Ser Leu 
        835                 840                 845             


Thr Ala Val Gln Leu Arg Asn Ala Leu Ser Ala Ala Thr Gly Leu Arg 
    850                 855                 860                 


Leu Ser Ala Thr Val Ala Phe Asp His Pro Thr Pro Ala Ala Leu Ala 
865                 870                 875                 880 


Ala Ala Leu 
            


<210>  99
<211>  874
<212>  PRT
<213>  Micromonospora sp.

<400>  99

Glu Pro Ile Ala Ile Val Gly Met Ala Cys Arg Leu Pro Gly Gly Val 
1               5                   10                  15      


Ser Ser Pro Asp Glu Leu Trp Glu Leu Val Glu Ser Gly Arg Asp Ala 
            20                  25                  30          


Ile Gly Pro Phe Pro Ala Asp Arg Gly Trp Asn Leu Asp Glu Leu Tyr 
        35                  40                  45              


Asp Pro Asp Pro Asp Ala Ala Gly Arg Ser Tyr Val Arg Glu Gly Gly 
    50                  55                  60                  


Phe Leu Thr Gly Ala Ala Asp Phe Asp Ala Gly Phe Phe Gly Ile Asn 
65                  70                  75                  80  


Pro Arg Glu Ala Leu Ala Met Asp Pro Gln Gln Arg Leu Val Leu Glu 
                85                  90                  95      


Val Ala Trp Glu Ala Phe Glu Arg Ala Gly Ile Ala Pro Asp Ser Leu 
            100                 105                 110         


Arg Gly Thr Asp Thr Gly Val Phe Leu Gly Ala Phe Ala Gly Gly Tyr 
        115                 120                 125             


Leu Thr Leu Val Asn Gly Ala Ala Asp Leu Glu Gly Tyr Ala Gly Thr 
    130                 135                 140                 


Gly Asn Ser Val Ser Val Leu Ser Gly Arg Leu Ser Tyr Val Leu Gly 
145                 150                 155                 160 


Leu Glu Gly Pro Ala Val Thr Val Asp Thr Ala Cys Ser Ser Ser Leu 
                165                 170                 175     


Val Ala Leu His Gln Ala Ala Gln Ala Leu Arg Leu Gly Glu Cys Ser 
            180                 185                 190         


Leu Ala Val Val Gly Gly Val Thr Val Met Ser Thr Pro Asp Ser His 
        195                 200                 205             


Val Glu Phe Ser Arg Gln Arg Ala Leu Ser Pro Asp Gly Arg Cys Lys 
    210                 215                 220                 


Ala Phe Ala Asp Gly Ala Asp Gly Thr Gly Trp Ala Glu Gly Ala Gly 
225                 230                 235                 240 


Val Leu Val Val Glu Arg Leu Ser Glu Ala Arg Arg Arg Gly His Thr 
                245                 250                 255     


Val Leu Ala Val Val Arg Gly Ser Ala Val Asn Gln Asp Gly Ala Ser 
            260                 265                 270         


Asn Gly Leu Thr Ala Pro Asn Gly Pro Ser Gln Gln Arg Val Ile Arg 
        275                 280                 285             


Ala Ala Leu Ala Ser Ala Gly Leu Gly Val Gly Asp Val Asp Leu Val 
    290                 295                 300                 


Glu Gly His Gly Thr Gly Thr Ala Leu Gly Asp Pro Ile Glu Ala Gln 
305                 310                 315                 320 


Ala Leu Leu Ala Thr Tyr Gly Ser Asp Gly Ser Pro Val Trp Leu Gly 
                325                 330                 335     


Ser Leu Lys Ser Asn Ile Gly His Thr Gln Ala Ala Ala Gly Val Ala 
            340                 345                 350         


Gly Val Ile Lys Ala Val Glu Ser Met Arg Arg Gly Val Met Pro Gln 
        355                 360                 365             


Thr Leu His Val Gly Thr Pro Ser Ser His Val Asp Trp Ala Ala Gly 
    370                 375                 380                 


Ala Val Glu Leu Leu Thr Ala Asn Arg Ala Trp Asp Ser Val Glu Arg 
385                 390                 395                 400 


Pro Arg Arg Ala Ala Val Ser Ser Phe Gly Ile Ser Gly Thr Asn Ala 
                405                 410                 415     


His Val Ile Leu Glu Gly Val Pro Ala Pro Glu Pro Ala Ala Gly Ser 
            420                 425                 430         


Ala Glu Ser Ala Pro Leu Leu Leu Ser Ala Arg Ser Ala Ala Ala Leu 
        435                 440                 445             


Ala Gln Phe Glu Ser Leu Thr Ser Gly Leu Arg Pro Ser Arg Asp Leu 
    450                 455                 460                 


Ala Ser Thr Leu Ser Arg Arg Ala Phe Phe Asp His Arg Ala Val Val 
465                 470                 475                 480 


Leu Pro Gly Gly Asp Val Val Arg Gly Arg Val Gly Asp Ala Pro Val 
                485                 490                 495     


Val Leu Val Phe Ala Gly Gln Gly Ser Gln Arg Ala Asp Met Ala Ser 
            500                 505                 510         


Arg Leu Thr Ala Glu Phe Pro Val Phe Ala Ala Ala His Glu Arg Val 
        515                 520                 525             


Trp Ser Leu Leu Asp Val Asp Glu Gly Leu Gly Ile Asp Gln Thr Gly 
    530                 535                 540                 


Phe Ala Gln Pro Ala Leu Phe Ala Tyr Glu Val Ala Leu Ala Glu Leu 
545                 550                 555                 560 


Leu Asp Val Arg Pro Asp Ala Val Ile Gly His Ser Ile Gly Glu Leu 
                565                 570                 575     


Ala Ala Ala Tyr Val Ala Gly Ala Val Ser Leu Glu Asp Ala Cys Arg 
            580                 585                 590         


Leu Val Ser Ala Arg Ala Arg Leu Met Gln Ala Leu Pro Pro Gly Gly 
        595                 600                 605             


Ala Met Val Ser Val Arg Val Ser Glu Glu Ala Ala Arg Ala Val Leu 
    610                 615                 620                 


Arg Asp Gly Val Glu Ile Ala Ala Val Asn Gly Pro Gln Ala Val Val 
625                 630                 635                 640 


Leu Ser Gly Asp Glu Asp Ala Val Leu Ala Ala Ala Ala Glu Leu Gly 
                645                 650                 655     


Glu Phe Lys Arg Leu Arg Thr Ser His Ala Phe His Ser Ala Arg Met 
            660                 665                 670         


Glu Pro Met Leu Asp Glu Phe Arg Ala Val Ala Leu Thr Val Glu Phe 
        675                 680                 685             


Arg Glu Pro Glu Val Ala Leu Ser Phe Val Pro Ser Ala Glu Tyr Phe 
    690                 695                 700                 


Val Arg Gln Val Arg Glu Thr Val Arg Phe Gly Glu Gln Val Ala Ala 
705                 710                 715                 720 


Phe Ala Pro Gly Thr Leu Phe Val Glu Val Gly Pro Asp Gly Ser Leu 
                725                 730                 735     


Ser Arg Leu Thr Gly Gly Val Ser Ala Ala Glu Pro Leu Thr Ala Leu 
            740                 745                 750         


Ala Tyr Leu Trp Val Arg Gly Val Gly Val Glu Trp Thr Pro Tyr Val 
        755                 760                 765             


Gly Gly Gly Ile Leu Asp Gln Gly Ala Pro Thr Tyr Pro Phe Gln Arg 
    770                 775                 780                 


Glu Arg Tyr Trp Val Arg Pro Arg Leu Ala Gly Arg Thr Thr Asp Glu 
785                 790                 795                 800 


Arg Asp Ala Leu Leu Ile Asp Leu Val Arg Asp Asp Val Ala Ser Val 
                805                 810                 815     


Leu Gly His Ser Gly Arg Arg Arg Leu Glu Thr Asp Arg Pro Leu Leu 
            820                 825                 830         


Glu Leu Gly Phe Asp Ser Leu Thr Ala Leu Arg Leu Arg Asn Arg Leu 
        835                 840                 845             


Ala Ala Ala Thr Asp Val Ala Leu Pro Ala Thr Leu Ile Phe Asp Tyr 
    850                 855                 860                 


Pro Asn Ile Gln Ala Ile Ala Val His Leu 
865                 870                 


<210>  100
<211>  898
<212>  PRT
<213>  Micromonospora sp.

<400>  100

Glu Pro Leu Ala Val Val Gly Met Ala Cys Arg Tyr Pro Gly Gly Val 
1               5                   10                  15      


Ala Ser Ala Asp Asp Leu Trp Arg Leu Val Ala Ala Gly Gly Asp Ala 
            20                  25                  30          


Val Gly Pro Phe Pro Asp Asp Arg Gly Trp Glu Leu Glu Ser Leu Val 
        35                  40                  45              


Asp Pro Asp Pro Glu Ala Val Gly Arg Ser Thr Thr Gly Gln Gly Gly 
    50                  55                  60                  


Phe Leu Ala Asp Ala Ala Gly Phe Asp Ala Ala Phe Phe Gly Ile Ser 
65                  70                  75                  80  


Pro Arg Glu Ala Thr Ala Met Asp Pro Gln Gln Arg Leu Leu Leu Glu 
                85                  90                  95      


Val Ser Trp Ala Ala Leu Glu His Ala Gly Leu Arg Ala Asp Ala Leu 
            100                 105                 110         


Arg Gly Ser Ala Thr Gly Val Phe Met Gly Ser Asn Gly Gln Asp Tyr 
        115                 120                 125             


Ala Gly Leu Leu Ala Gly Ala Pro Glu Leu Glu Gly Trp Ile Gly Thr 
    130                 135                 140                 


Gly Val Ser Ala Ser Val Val Ser Gly Arg Leu Ser Tyr Phe Tyr Gly 
145                 150                 155                 160 


Phe Glu Gly Pro Ala Val Thr Val Asp Thr Ala Cys Ser Ser Ser Leu 
                165                 170                 175     


Val Ala Leu His Leu Ala Ala Gln Ser Leu Arg Thr Gly Glu Ser Ser 
            180                 185                 190         


Leu Ala Leu Val Gly Gly Val Thr Val Met Thr Ser Pro Thr Val Phe 
        195                 200                 205             


Arg Ser Phe Ser Arg Gln Arg Gly Leu Ala Pro Asp Gly Arg Cys Lys 
    210                 215                 220                 


Ala Phe Ser Ala Gly Ala Asp Gly Thr Gly Trp Ser Glu Gly Val Gly 
225                 230                 235                 240 


Val Leu Val Val Glu Arg Leu Ser Asp Ala Gln Arg Asn Gly His Gln 
                245                 250                 255     


Ile Leu Ala Val Val Arg Gly Ser Ala Val Asn Gln Asp Gly Ala Ser 
            260                 265                 270         


Asn Gly Leu Thr Ala Pro His Gly Pro Ser Gln Gln Arg Val Ile Asn 
        275                 280                 285             


Thr Ala Leu Thr Asp Ala Asp Leu Thr Thr Thr Asp Ile Asp Leu Ile 
    290                 295                 300                 


Glu Ala His Gly Thr Gly Thr Thr Leu Gly Asp Pro Ile Glu Ala Gln 
305                 310                 315                 320 


Ala Ile Leu Ala Thr Tyr Gly Asn Arg Thr Thr Gly Asn Pro Val His 
                325                 330                 335     


Leu Gly Ser Val Lys Ser Asn Leu Gly His Thr Gln Ala Ala Ala Gly 
            340                 345                 350         


Ile Ala Gly Ile Ile Lys Ala Ile Gln Ala Met Arg His Ala Thr Met 
        355                 360                 365             


Pro Arg Thr Leu His Ile Asp Glu Pro Ser Pro His Val Asp Trp Thr 
    370                 375                 380                 


Ala Gly Arg Val Glu Leu Leu Thr Ser Asn Leu Pro Trp Pro Ala Thr 
385                 390                 395                 400 


Gly Arg Pro Arg Arg Ala Ala Val Ser Ser Phe Gly Val Ser Gly Thr 
                405                 410                 415     


Asn Ala His Val Ile Leu Glu Glu Ala Pro Ala Pro Ala Ala Val Pro 
            420                 425                 430         


Ser Ile Arg Pro Val Val Ser Gly Pro Ala Leu Pro Leu Val Phe Ser 
        435                 440                 445             


Ala Lys Asp Pro Asp Ala Leu Ala Glu Phe Gln Ser His Thr Pro Ala 
    450                 455                 460                 


Gly Glu Gly Val Ala Tyr Ala Leu Ala Thr Ser Arg Ser Thr Leu Asp 
465                 470                 475                 480 


His Arg Ser Val Arg Ile Gly Asp Val Thr Val Thr Gly Ile Ala Val 
                485                 490                 495     


Thr Asp Pro Glu Val Val Phe Val Phe Pro Gly Gln Gly Thr Gln Trp 
            500                 505                 510         


Ala Gly Met Gly Arg Asp Leu Met Ser Ala Ser Pro Val Phe Ala Glu 
        515                 520                 525             


Arg Met Asn Glu Cys Ala Ala Ala Leu Glu Pro Tyr Leu Asp Leu Trp 
    530                 535                 540                 


Ala Ala Ile Asp Ala Pro Asp Arg Val Glu Thr Leu Gln Pro Ala Ser 
545                 550                 555                 560 


Trp Ala Met Met Val Ser Leu Ala Ala Val Trp Gln Ala Ala Gly Val 
                565                 570                 575     


Gln Pro Ala Ala Val Ile Gly His Ser Gln Gly Glu Ile Ala Ala Ala 
            580                 585                 590         


Cys Val Ser Gly Ala Ile Ser Leu Gln Asp Ala Ala Ala Val Val Ala 
        595                 600                 605             


Leu Arg Ser Lys Ala Ile Ala Ala Ser Leu Gly Lys Gly Ala Met Ala 
    610                 615                 620                 


Ser Ile Pro Leu Pro Ala Asp Ala Ile Glu Leu Thr Gly Glu Val Trp 
625                 630                 635                 640 


Val Ala Ala Leu Asn Gly Pro Ser Ser Thr Val Val Ala Gly Val Pro 
                645                 650                 655     


Glu Ala Val Glu Leu Val Arg Ala Arg Tyr Glu Gly Arg Arg Ile Ala 
            660                 665                 670         


Val Asp Tyr Ala Ser His Thr Pro His Val Glu Ala Leu Arg Gly Gln 
        675                 680                 685             


Val Val Ser Val Pro Ser Gln Ala Pro Val Ile Pro Trp Phe Ser Thr 
    690                 695                 700                 


Val Asp Ser Gly Trp Val Glu Gly Pro Leu Asp Asp Asp Tyr Trp Phe 
705                 710                 715                 720 


Arg Asn Leu Arg Gln Pro Val Gln Phe Gly Pro Ala Ala Ala Gly Phe 
                725                 730                 735     


Asp Asn Ala Val Phe Ile Glu Val Ser Ala Arg Pro Val Leu Ile Pro 
            740                 745                 750         


Ala Leu Asp Ala Ser Val Thr Val Pro Ser Leu Arg Arg Asp Asp Gly 
        755                 760                 765             


Gly Pro Glu Arg Met Leu Ala Ser Leu Ala Gln Ala Phe Val Ala Gly 
    770                 775                 780                 


Val Pro Val Asp Trp Thr Thr Ile Val Pro Pro Ala Pro His Val Asp 
785                 790                 795                 800 


Leu Pro Ser Tyr Pro Phe Gln His Gln Arg Phe Trp Ile Glu Gly Arg 
                805                 810                 815     


Val Thr Ala Ala Ala Gly Ala Glu Arg Leu Arg Ile Met Leu Glu Val 
            820                 825                 830         


Val Leu Ala Glu Thr Ala Thr Val Leu Gly His Gly Gly Ala Ala Ala 
        835                 840                 845             


Ile Gly Pro Gly Arg Ala Phe Gln Asp Leu Gly Phe Asp Ser Leu Thr 
    850                 855                 860                 


Ala Val Glu Leu Arg Asn Arg Leu Ala Ala Ala Thr Gly Leu Thr Leu 
865                 870                 875                 880 


Pro Thr Thr Leu Val Phe Asn His Pro Thr Pro Glu Ala Leu Ala Ala 
                885                 890                 895     


His Leu 
        


<210>  101
<211>  947
<212>  PRT
<213>  Micromonospora sp.

<400>  101

Glu Pro Val Ala Ile Val Gly Met Ala Cys Arg Leu Pro Gly Asp Val 
1               5                   10                  15      


Glu Ser Pro Glu Asp Leu Trp Arg Leu Val Ala Glu Gly Arg Asp Ala 
            20                  25                  30          


Val Gly Pro Phe Pro Ser Asp Arg Gly Trp Asn Leu Gly Thr Leu Asp 
        35                  40                  45              


Asp Pro Asp Ala Ala Gly Arg Ser Tyr Val Lys Glu Gly Gly Phe Leu 
    50                  55                  60                  


Ala Gly Ala Ala His Phe Asp Pro Ala Phe Phe Gly Ile Gly Pro Arg 
65                  70                  75                  80  


Glu Ala Leu Gly Met Asp Pro Gln Gln Arg Ile Leu Leu Glu Ile Ala 
                85                  90                  95      


Trp Glu Ala Leu Glu His Ala Arg Ile Ala Pro Gly Asp Leu Arg Gly 
            100                 105                 110         


Ser Glu Thr Gly Val Tyr Val Gly Ala Ala Ala Gln Gly Tyr Gly Val 
        115                 120                 125             


Asp Ala Pro Leu Glu Gly Asn Leu Leu Thr Gly Gly Ser Thr Ser Ala 
    130                 135                 140                 


Met Ser Gly Arg Val Ala Tyr Ala Leu Gly Leu His Gly Pro Ala Val 
145                 150                 155                 160 


Thr Val Asp Thr Ala Cys Ser Ser Ser Leu Val Ala Leu His Leu Ala 
                165                 170                 175     


Ala Gln Ala Leu Arg His Gly Glu Cys Thr Leu Ala Leu Ala Gly Gly 
            180                 185                 190         


Val Ala Val Met Ala Ser Pro Val Leu Phe Thr Glu Phe Ser Arg Gln 
        195                 200                 205             


Arg Gly Leu Ala Pro Asp Gly Arg Cys Lys Ala Phe Ala Ala Ala Ala 
    210                 215                 220                 


Asp Gly Thr Gly Trp Ser Glu Gly Ala Gly Leu Val Val Leu Glu Arg 
225                 230                 235                 240 


Leu Ser Asp Ala Glu Arg His Gly His Arg Val Leu Ala Val Ile Arg 
                245                 250                 255     


Gly Ser Ala Val Asn Ser Asp Gly Ala Ser Asn Gly Leu Thr Ala Pro 
            260                 265                 270         


Asn Gly Thr Ala Gln Arg Arg Val Ile Arg Ser Ala Leu Arg Ala Ala 
        275                 280                 285             


Gly Leu Gly Ala Gly Asp Val Asp Val Val Glu Ala His Gly Thr Gly 
    290                 295                 300                 


Thr Thr Leu Gly Asp Pro Val Glu Ala Asp Ala Leu Ile Ala Thr Tyr 
305                 310                 315                 320 


Gly Gln Arg Ser Asp Thr Pro Pro Val Arg Ile Gly Ser Leu Lys Ser 
                325                 330                 335     


Asn Ile Gly His Thr Val Ala Ala Ala Gly Val Ala Gly Val Ile Lys 
            340                 345                 350         


Met Val Glu Ala Met Arg His Gly Thr Met Pro Arg Thr Leu His Val 
        355                 360                 365             


Asp Arg Pro Thr Pro His Val Asp Trp Ser Ala Gly Ala Ala Glu Leu 
    370                 375                 380                 


Leu Thr Gly Glu Leu Pro Trp Pro Arg Gly Asp Arg Pro Arg Arg Ala 
385                 390                 395                 400 


Ala Val Ser Ala Phe Gly Leu Ser Gly Thr Asn Ala His Leu Ile Leu 
                405                 410                 415     


Glu Asp Val Ala Ala Ala Ala Glu Pro Pro Ala Gly Asp Asp Ser Gly 
            420                 425                 430         


Ser Gly Ser Glu Thr Val Pro Leu Leu Leu Ser Ala Asp Asp Leu Pro 
        435                 440                 445             


Ala Val Arg Asp Gln Ala Ala Arg Leu Arg Ala His Leu Leu Ala His 
    450                 455                 460                 


Pro Glu Leu Arg Met Arg Asp Val Ala Tyr Ala Leu Ala Thr Thr Arg 
465                 470                 475                 480 


Thr Ala Arg Pro His Arg Ala Ala Val Thr Ala Thr Glu Arg Glu Leu 
                485                 490                 495     


Leu Arg Glu Leu Ala Leu Leu Ala Ala Gly Asp Gln Gly Pro Gly Thr 
            500                 505                 510         


Gln Leu Gly Glu Ala Val Pro His Arg Arg Val Ala Phe Leu Phe Asp 
        515                 520                 525             


Gly Gln Gly Thr Gln Arg His Gly Met Gly Arg Ala Leu His Gln Arg 
    530                 535                 540                 


His Pro Val Phe Ala Ala Ala Trp Asp Glu Val Cys Ala Ala Leu Asp 
545                 550                 555                 560 


Pro Leu Leu Asp Arg Gly Val Ala Glu Val Tyr Phe Ala Glu Ala Gly 
                565                 570                 575     


Arg Asp Leu Ala Asp Asp Pro Leu Tyr Thr Gln Ala Gly Leu Phe Ala 
            580                 585                 590         


Leu Glu Val Ala Leu Tyr Arg Leu Leu Thr Ser Trp Gly Val Thr Pro 
        595                 600                 605             


Asp Ala Val Ala Gly His Ser Val Gly Glu Val Ala Val Ala His Val 
    610                 615                 620                 


Ala Gly Val Leu Ser Leu Pro Asp Ala Ala Ser Leu Leu Ala Ala Arg 
625                 630                 635                 640 


Gly Ala Ala Leu Arg Gln Leu Pro Pro Gly Ala Met Ala Ala Ile Arg 
                645                 650                 655     


Ala Ser Glu Asp Asp Thr Arg Gly Val Leu Pro Pro Asp Leu Asp Val 
            660                 665                 670         


Ala Ala Val Asn Gly Pro Glu Met Thr Val Val Ser Gly Ala Glu Glu 
        675                 680                 685             


Ala Val Asp Arg Phe Val Ala Glu Gln Ala Gly Ala Gly Arg Gln Val 
    690                 695                 700                 


Arg Arg Leu Arg Val Gly Arg Ala Tyr His Ser Arg His Val Asp Ala 
705                 710                 715                 720 


Val Leu Ala Glu Phe Gly Ala Thr Leu Ser Ala Leu Thr Phe His Glu 
                725                 730                 735     


Pro Thr Leu Pro Val Val Ser Thr Val Thr Gly Arg Pro Ala Gly Ala 
            740                 745                 750         


Gly Asp Leu Thr Thr Pro Glu Tyr Trp Leu Arg His Ala Arg Arg Pro 
        755                 760                 765             


Val Arg Phe Gly Ala Ala Leu Ala Ser Leu Ser Glu Leu Gly Met Asp 
    770                 775                 780                 


Ser Phe Val Glu Val Gly Pro Ser Gly Ser Leu Ser Ser Met Ala Gly 
785                 790                 795                 800 


Glu Thr Val Ala Gly Thr Phe His Pro Leu Leu Asp Arg Arg Val Pro 
                805                 810                 815     


Asp Glu Ile Gly Ala Ala Ala Ala Ala Gly Glu Leu Phe Thr Ala Gly 
            820                 825                 830         


Met Ala Leu Asp Trp Thr Ala Val Leu Ala Gly Gly Arg Pro Ile Asp 
        835                 840                 845             


Leu Pro Val Tyr Pro Phe Arg Arg Glu Phe Tyr Trp Leu Gly Ala Arg 
    850                 855                 860                 


Tyr Asp Leu Met Ala Ala Ala Val Arg Arg Asp Ala Leu Leu Asp Leu 
865                 870                 875                 880 


Val Arg Val Gln Val Ala Leu Leu Leu Gly Arg Ala Asp Ala Ile Gly 
                885                 890                 895     


Val Arg Asp Asn Thr Ser Phe Leu Asp Val Gly Leu Asp Ser Leu Gly 
            900                 905                 910         


Ala Ser Arg Leu Arg Asn Arg Leu Ala Ala Ala Thr Gly Leu Thr Leu 
        915                 920                 925             


Pro Gly Gly Leu Ala Phe Asp His Pro Thr Pro Ala Arg Leu Ala Asp 
    930                 935                 940                 


His Leu Asp 
945         


<210>  102
<211>  913
<212>  PRT
<213>  Catellatospora ferruginea

<400>  102

Glu Pro Leu Ala Ile Val Gly Met Ala Cys Arg Leu Pro Gly Gly Val 
1               5                   10                  15      


Trp Ser Pro Glu Asp Leu Trp His Leu Val Ala Ser Gly Thr Asp Ala 
            20                  25                  30          


Ile Ser Asp Phe Pro Ala Asp Arg Gly Trp Asp Val Glu Lys Leu Phe 
        35                  40                  45              


Asp Pro Asp Pro Asp Ala Pro Gly Lys Thr Tyr Cys Val Gln Gly Gly 
    50                  55                  60                  


Phe Leu Glu Ala Thr Ala Ala Phe Asp Ala Ala Phe Phe Gly Ile Ser 
65                  70                  75                  80  


Pro Arg Glu Ala Leu Ala Met Asp Pro Gln Gln Arg Leu Met Leu Glu 
                85                  90                  95      


Val Ser Trp Glu Ala Phe Glu Arg Ala Gly Ile Glu Pro Gly Ser Val 
            100                 105                 110         


Arg Gly Ser Asp Thr Gly Val Phe Leu Gly Ala Tyr Pro Gly Gly Tyr 
        115                 120                 125             


Gly Ala Gly Ala Gly Ala Asp Leu Gly Gly Phe Gly Ala Thr Gly Gly 
    130                 135                 140                 


Ala Gly Ser Val Leu Ser Gly Arg Val Ser Tyr Phe Phe Gly Leu Glu 
145                 150                 155                 160 


Gly Pro Ala Met Thr Val Asp Thr Ala Cys Ser Ser Ser Leu Val Ala 
                165                 170                 175     


Leu His Gln Ala Ala Tyr Ser Leu Arg Gln Arg Glu Cys Ser Leu Ala 
            180                 185                 190         


Leu Val Gly Gly Val Thr Val Met Gly Thr Pro His Met Phe Val Asp 
        195                 200                 205             


Phe Ser Arg Gln Arg Gly Leu Ser Val Asp Gly Arg Cys Lys Ala Phe 
    210                 215                 220                 


Ala Asp Ala Ala Asp Gly Thr Ser Trp Ser Glu Gly Val Gly Val Leu 
225                 230                 235                 240 


Leu Val Glu Arg Leu Ser Asp Ala Gln Ala Lys Gly His Arg Val Leu 
                245                 250                 255     


Ala Val Val Lys Gly Ser Ala Val Asn Gln Asp Gly Ala Ser Asn Gly 
            260                 265                 270         


Leu Thr Ala Pro Asn Gly Pro Ser Gln Gln Arg Val Ile Arg Gln Ala 
        275                 280                 285             


Leu Ala Asn Ala Asp Leu Ala Pro His Glu Val Asp Val Val Glu Ala 
    290                 295                 300                 


His Gly Thr Gly Thr Thr Leu Gly Asp Pro Ile Glu Ala Gln Ala Leu 
305                 310                 315                 320 


Leu Ala Thr Tyr Gly Gln Asp Arg Glu Gln Pro Leu Leu Leu Gly Ser 
                325                 330                 335     


Leu Lys Ser Asn Val Gly His Thr Gln Ala Ala Ala Gly Val Ser Gly 
            340                 345                 350         


Val Ile Lys Met Val Met Ala Leu Gln His Gly Val Val Pro Arg Thr 
        355                 360                 365             


Leu His Val Asp Glu Pro Ser Arg His Val Asp Trp Ser Ala Gly Ala 
    370                 375                 380                 


Val Glu Leu Val Thr Gln Asn Gln Pro Trp Pro Ser Ser Asp Arg Pro 
385                 390                 395                 400 


Arg Arg Ala Gly Val Ser Ser Phe Gly Val Ser Gly Thr Asn Ala His 
                405                 410                 415     


Ile Ile Leu Glu Ser Ala Pro Ala Gln Pro Leu Ala Pro Ser Thr Pro 
            420                 425                 430         


Ile Thr Gly Leu Val Pro Leu Val Ile Ser Ala Lys Thr Ala Pro Ala 
        435                 440                 445             


Leu Thr Ala Phe Glu Ala Arg Leu Arg Ser Tyr Val Thr Ala Asp Ala 
    450                 455                 460                 


Asp Leu Thr Ala Ile Ala Ala Thr Leu Ala Thr Thr Arg Ser Thr Phe 
465                 470                 475                 480 


Glu His Arg Ala Val Leu Leu Gly Asp Asp Thr Val Thr Gly Ile Ala 
                485                 490                 495     


Thr Pro Asp Pro Arg Val Val Phe Val Phe Pro Gly Gln Gly Trp Gln 
            500                 505                 510         


Trp Leu Gly Met Gly Ser Ala Leu Arg Glu Thr Ser Val Val Phe Lys 
        515                 520                 525             


Glu Arg Met Ala Glu Cys Ala Ala Ala Leu Ser Glu Phe Val Asp Trp 
    530                 535                 540                 


Asp Leu Phe Ser Val Leu Asp Asp Pro Ala Val Val Asp Arg Val Asp 
545                 550                 555                 560 


Val Val Gln Pro Ala Cys Trp Ala Val Met Val Ser Leu Ala Ala Thr 
                565                 570                 575     


Trp Gln Ala Ala Gly Ala Arg Pro Asp Ala Val Val Gly His Ser Gln 
            580                 585                 590         


Gly Glu Ile Ala Ala Ala Cys Val Ala Gly Ala Ile Ser Leu Gln Asp 
        595                 600                 605             


Gly Ala Arg Val Val Ala Leu Arg Ser Gln Leu Ile Ala Arg Leu Ala 
    610                 615                 620                 


Gly His Gly Ala Met Ala Ser Ile Ala Leu Pro Ala Asp Gln Ile Thr 
625                 630                 635                 640 


Leu Thr Asp Gly Val Trp Ile Ala Ala Arg Asn Gly Pro Ala Ala Thr 
                645                 650                 655     


Val Ile Ala Gly Ala Pro Glu Ala Val Asp Ser Val Leu Ala Ala His 
            660                 665                 670         


Gln Asp Ala Arg Val Arg Arg Ile Thr Val Asp Tyr Ala Ser His Thr 
        675                 680                 685             


Pro His Val Glu Lys Ile Arg Asp Glu Leu Leu Pro Met Leu Ala Asp 
    690                 695                 700                 


Ile Asp Ser Gln Thr Pro Leu Val Pro Trp Leu Ser Thr Val Asp Gly 
705                 710                 715                 720 


Leu Phe Ile Glu Gly Pro Leu Lys Ala Asp Tyr Trp Tyr Arg Asn Leu 
                725                 730                 735     


Arg Glu Gln Val Gly Phe Asp Thr Ala Val Asn Gln Leu Pro Asp Ser 
            740                 745                 750         


Ile Phe Ile Glu Val Ser Ala Ser Pro Val Leu Leu Pro Gly Met Gly 
        755                 760                 765             


Asp Ala Leu Thr Val Ala Thr Leu Arg Arg Asp Glu Gly Gly Gln Glu 
    770                 775                 780                 


Arg Leu Val Thr Ala Leu Ala Glu Ala Tyr Val Gln Gly Val Ala Val 
785                 790                 795                 800 


Asp Trp Ala Ala Val Ile Tyr Asn Thr Thr Ala Leu Val Asp Leu Pro 
                805                 810                 815     


Thr Tyr Pro Phe Gln His Glu His Tyr Trp Leu Asp Ser Thr Arg Leu 
            820                 825                 830         


Met Gly Leu Ala Ala Glu Glu Arg Asp Lys Ala Leu Val Ala Val Val 
        835                 840                 845             


Arg Glu Ser Ala Ala Val Val Leu Gly His Ala Asp Ala Arg Ala Ile 
    850                 855                 860                 


Pro Ala Thr Ala Ala Phe Arg Glu Leu Gly Val Asp Ser Leu Thr Ala 
865                 870                 875                 880 


Val Gln Leu Arg Asn Ser Leu Ala Lys Ala Thr Gly Leu Arg Leu Pro 
                885                 890                 895     


Thr Thr Leu Ala Phe Asp Tyr Pro Thr Pro Ala Val Leu Ala Ala Arg 
            900                 905                 910         


Leu 
    


<210>  103
<211>  910
<212>  PRT
<213>  Catellatospora ferruginea

<400>  103

Glu Pro Leu Ala Ile Val Gly Met Ala Cys Arg Leu Pro Gly Gly Val 
1               5                   10                  15      


Ser Ser Pro Glu Asp Leu Trp Arg Leu Val Glu Ser Gly Thr Asp Ala 
            20                  25                  30          


Ile Ser Asp Leu Pro Thr Asp Arg Gly Trp Asp Leu Asp Asn Leu Tyr 
        35                  40                  45              


Asp Pro Asp Pro Gly Ala Pro Gly Lys Ser Tyr Cys Val Gln Gly Gly 
    50                  55                  60                  


Phe Leu Asp Thr Val Ala Asp Phe Asp Pro Ala Phe Phe Gly Ile Ser 
65                  70                  75                  80  


Pro Arg Glu Ala Leu Ala Met Asp Pro Gln Gln Arg Leu Val Leu Glu 
                85                  90                  95      


Val Ser Trp Glu Ala Phe Glu Arg Ala Gly Ile Glu Pro Gly Ser Val 
            100                 105                 110         


Arg Gly Ser Asp Thr Gly Val Phe Met Gly Ala Phe Gly Asn Gly Tyr 
        115                 120                 125             


Gly Ile Asp Thr Asp Gly Gly Gly Phe Gly Ala Thr Ala Gly Thr Gly 
    130                 135                 140                 


Ser Val Leu Ser Gly Arg Val Ser Tyr Phe Leu Gly Leu Glu Gly Pro 
145                 150                 155                 160 


Ala Met Thr Val Asp Thr Gly Cys Ser Ser Ala Leu Val Ala Leu His 
                165                 170                 175     


Gln Ala Arg Tyr Ala Leu Arg Gln Gly Asp Cys Ser Leu Ala Leu Val 
            180                 185                 190         


Gly Gly Val Thr Val Met Ala Ser Pro Tyr Thr Phe Val Glu Phe Ser 
        195                 200                 205             


Arg Gln Arg Gly Met Ala Ala Asp Gly Arg Cys Lys Ala Phe Ala Asp 
    210                 215                 220                 


Ala Ala Asp Gly Thr Gly Trp Ala Glu Gly Val Gly Val Leu Leu Val 
225                 230                 235                 240 


Glu Arg Leu Ser Asp Ala Glu Ala Lys Gly His Gln Val Leu Ala Val 
                245                 250                 255     


Val Arg Gly Ser Ala Leu Asn Gln Asp Gly Ala Ser Asn Gly Leu Thr 
            260                 265                 270         


Ala Pro Asn Gly Pro Ser Gln Gln Arg Val Ile Gln Ala Ala Leu Ala 
        275                 280                 285             


Asn Ala Gly Leu Val Ser Ala Asp Val Asp Val Val Glu Ala His Gly 
    290                 295                 300                 


Thr Gly Thr Thr Leu Gly Asp Pro Ile Glu Ala Gln Ala Val Leu Ala 
305                 310                 315                 320 


Thr Tyr Gly Gln Asp Arg Glu Arg Pro Leu Leu Leu Gly Ser Leu Lys 
                325                 330                 335     


Ser Asn Ile Gly His Thr Gln Ala Ala Ala Gly Val Ser Gly Val Ile 
            340                 345                 350         


Lys Met Val Met Ala Leu Gln His Gly Val Val Pro Arg Thr Leu His 
        355                 360                 365             


Val Asp Glu Pro Ser Arg His Val Asp Trp Ser Ala Gly Ala Val Glu 
    370                 375                 380                 


Leu Val Thr Glu Asn Gln Pro Trp Pro Ser Val Asp Arg Pro Pro Arg 
385                 390                 395                 400 


Ala Gly Val Ser Ala Phe Gly Ile Ser Gly Thr Asn Ala His Val Ile 
                405                 410                 415     


Leu Glu Ala Val Pro Ala Pro Pro Phe Glu Pro Pro Thr Pro Val Thr 
            420                 425                 430         


Gly Pro Val Pro Leu Val Ile Ser Ala Lys Thr Arg Pro Ala Leu Thr 
        435                 440                 445             


Ala Phe Glu Ala Arg Leu Arg Ala Tyr Val Thr Ala Asp Ala Asp Leu 
    450                 455                 460                 


Thr Ala Ile Ala Ser Thr Leu Ala Thr Thr Arg Ser Ile Phe Glu His 
465                 470                 475                 480 


Arg Ala Val Leu Leu Gly Asp Asp Thr Val Thr Gly Ile Ala Val Pro 
                485                 490                 495     


Asp Pro Arg Val Val Phe Val Phe Pro Gly Gln Gly Trp Gln Trp Leu 
            500                 505                 510         


Gly Met Gly Ser Ala Leu Arg Glu Ser Ser Val Val Phe Ala Glu Arg 
        515                 520                 525             


Met Ala Glu Cys Ala Ala Ala Leu Ser Asp Tyr Val Asp Trp Asp Leu 
    530                 535                 540                 


Phe Ser Val Leu Asp Asp Pro Ala Val Val Asp Arg Val Asp Val Val 
545                 550                 555                 560 


Gln Pro Ala Cys Trp Ala Val Met Val Ser Leu Ala Ala Thr Trp Gln 
                565                 570                 575     


Ala Ala Gly Val Arg Pro Asp Ala Val Ile Gly His Ser Gln Gly Glu 
            580                 585                 590         


Ile Ala Ala Ala Cys Val Ala Gly Ala Ile Ser Leu Arg Asp Ala Ala 
        595                 600                 605             


Gln Ile Val Ala Leu Arg Ser Gln Leu Ile Ala Gly Leu Ala Gly His 
    610                 615                 620                 


Gly Ala Met Ala Ser Ile Ala Leu Ser Ala Asp Gln Ile Thr Leu Thr 
625                 630                 635                 640 


Asp Gly Ala Trp Ile Ala Ala Arg Asn Gly Pro Ala Ala Thr Val Ile 
                645                 650                 655     


Ala Gly Ala Pro Ala Ala Val Asp Ser Val Leu Ala Ala His Glu Asp 
            660                 665                 670         


Ala Arg Thr Arg Arg Ile Thr Val Asp Tyr Ala Ser His Thr Pro His 
        675                 680                 685             


Val Glu Gln Ile Arg Thr Glu Leu Leu Asp Leu Thr Thr Asp Leu Asp 
    690                 695                 700                 


Ser Arg Ala Pro Val Ile Pro Trp Leu Ser Thr Val Asp Val Thr Trp 
705                 710                 715                 720 


Val Glu Gly Pro Leu Asp Ala Asp Tyr Trp Tyr Arg Asn Leu Arg Glu 
                725                 730                 735     


Pro Val Gly Phe Asp Thr Ala Val Glu Asn Leu Pro Asp Ser Val Phe 
            740                 745                 750         


Ile Glu Val Ser Ala Asn Pro Val Leu Leu Pro Ala Met Gly Asp Ala 
        755                 760                 765             


Leu Thr Val Ala Thr Leu Arg Arg Asp Ala Gly Gly Gln Thr Arg Leu 
    770                 775                 780                 


Leu Thr Ala Leu Ala Glu Ala Tyr Val Gln Gly Val Ala Val Asp Trp 
785                 790                 795                 800 


Val Thr Val Ile Gly Ala Thr Pro Ala Arg Val Asp Leu Pro Thr Tyr 
                805                 810                 815     


Ala Phe Gln His Gln Arg Tyr Trp Val Ala Asp Arg Leu His Asp Arg 
            820                 825                 830         


Pro Ser Ala Glu Gln His Arg Leu Met Arg Glu Leu Val Gln Arg His 
        835                 840                 845             


Ala Ala Thr Val Leu Gly His Ala Ser Pro Asp Thr Ile Ala Ala Asp 
    850                 855                 860                 


Arg Pro Phe Lys Asp Leu Gly Leu Asp Ser Leu Thr Ala Val Glu Leu 
865                 870                 875                 880 


Arg Asn His Leu Val Ala Glu Thr Gly Leu Arg Leu Ser Ala Thr Thr 
                885                 890                 895     


Ala Phe Asp His Pro Thr Ala Asp Asp Leu Ala Gly His Leu 
            900                 905                 910 


<210>  104
<211>  954
<212>  PRT
<213>  Catellatospora ferruginea

<400>  104

Glu Pro Ile Ala Ile Val Ala Met Ala Cys Arg Ala Pro Gly Gly Val 
1               5                   10                  15      


Ser Ser Pro Glu Gly Leu Trp Arg Leu Val Glu Ser Gly Thr Asp Ala 
            20                  25                  30          


Thr Ser Gly Phe Pro Thr Asp Arg Gly Trp Asp Val Asp Asn Leu Phe 
        35                  40                  45              


Asp Pro Asp Pro Asp Ala Ala Gly Lys Thr Tyr Ser Val Arg Gly Gly 
    50                  55                  60                  


Phe Leu Glu Thr Ala Ala Asp Phe Asp Ala Ala Phe Phe Gly Ile Ser 
65                  70                  75                  80  


Pro Arg Glu Ala Leu Gly Met Asp Pro Gln Gln Arg Leu Leu Leu Glu 
                85                  90                  95      


Thr Ser Trp Glu Ala Ile Glu Arg Ala Gln Ile Asp Pro Lys Ser Leu 
            100                 105                 110         


Arg Gly Arg Asp Val Gly Val Tyr Val Gly Gly Ala Ala Gln Gly Tyr 
        115                 120                 125             


Gly Ile Gly Ala Thr Asp Gln Gln Gln Glu Asn Leu Ile Thr Gly Ser 
    130                 135                 140                 


Ser Ile Ser Leu Leu Ser Gly Arg Val Ser Tyr Ala Leu Gly Leu Glu 
145                 150                 155                 160 


Gly Pro Gly Val Thr Val Asp Thr Ala Cys Ser Ser Ser Leu Val Ala 
                165                 170                 175     


Leu His Leu Ala Ser Gln Ala Leu Arg Gln Arg Glu Cys Ser Leu Ala 
            180                 185                 190         


Leu Val Ser Gly Val Ser Val Met Ala Thr Pro Asp Val Phe Val Glu 
        195                 200                 205             


Phe Ser Arg Gln Arg Gly Leu Ala Ala Asp Gly Arg Cys Lys Ser Phe 
    210                 215                 220                 


Ser Ala Ala Ala Asp Gly Thr Thr Trp Ser Glu Gly Val Gly Val Leu 
225                 230                 235                 240 


Val Leu Gln Arg Leu Ser Glu Ala Val Arg Glu Gly His Arg Val Leu 
                245                 250                 255     


Ala Val Val Arg Gly Ser Ala Val Asn Ser Asp Gly Ala Ser Asn Gly 
            260                 265                 270         


Leu Thr Ala Pro Asn Gly Val Ser Gln Gln Arg Val Ile Arg Gln Ala 
        275                 280                 285             


Leu Ala Gly Ala Gly Leu Thr Ala Ser Glu Val Asp Val Val Glu Ala 
    290                 295                 300                 


His Gly Thr Gly Thr Lys Leu Gly Asp Pro Ile Glu Ala Glu Ala Ile 
305                 310                 315                 320 


Leu Ala Thr Tyr Gly Gln Asp Arg Asp Ala Pro Ala Trp Leu Gly Ser 
                325                 330                 335     


Leu Lys Ser Asn Ile Gly His Thr Met Ala Ala Ser Gly Val Leu Gly 
            340                 345                 350         


Val Ile Lys Met Val Gln Ala Met Arg His Gly Leu Leu Pro Arg Thr 
        355                 360                 365             


Leu His Val Asp Glu Pro Ser Pro His Val Asp Trp Ala Arg Gly Asp 
    370                 375                 380                 


Ile Ala Leu Leu Thr Glu Asn Gln Pro Trp Pro Asp Gly Thr Arg Pro 
385                 390                 395                 400 


Arg Arg Ala Gly Val Ser Ser Phe Gly Leu Ser Gly Thr Asn Ala His 
                405                 410                 415     


Val Val Leu Glu Glu Tyr Pro Ala Pro Val Ala Ala Ala Pro Pro Val 
            420                 425                 430         


Thr Pro Ala Arg Gly Gly Pro Leu Pro Trp Val Leu Ser Ala Gln Ser 
        435                 440                 445             


Pro Asn Ala Leu Arg Glu Gln Ala Ala Arg Leu Tyr Ala Ala Leu Ala 
    450                 455                 460                 


Glu Asp Pro Asp Trp His Pro Leu Asp Ile Gly Tyr Ser Leu Ala Thr 
465                 470                 475                 480 


Thr Arg Pro Gly Phe Pro His Arg Ala Val Ala Val Gly Ser Asp Arg 
                485                 490                 495     


Glu Asp Phe Gln Arg Ala Leu Ser Lys Leu Ala Asp Gly Ala Gly Trp 
            500                 505                 510         


Pro Gly Leu Ile Thr Ala Thr Ala Ala Lys Asp Arg Arg Val Ala Phe 
        515                 520                 525             


Leu Phe Asp Gly Gln Gly Thr Gln Arg Leu Gly Met Gly Arg Gly Leu 
    530                 535                 540                 


His Arg Arg Phe Pro Val Phe Ala Arg Ala Trp Asp Ala Val Ser Ala 
545                 550                 555                 560 


Ala Phe Ala Lys His Leu Asp His Ser Leu Thr Asp Ile Tyr Leu Gly 
                565                 570                 575     


Glu Ser Ser Pro Thr Asn Thr Asp Leu Ala Asp Asp Thr Leu Tyr Ala 
            580                 585                 590         


Gln Ala Gly Ile Phe Thr Leu Glu Val Ala Leu Val Glu Leu Leu Gln 
        595                 600                 605             


Asp Trp Gly Val Arg Pro Asp Phe Val Thr Gly His Ser Ile Gly Glu 
    610                 615                 620                 


Ala Ala Ala Ala Tyr Val Ala Gly Val Leu Ser Leu Glu Asp Val Thr 
625                 630                 635                 640 


Ala Leu Ile Val Ala Arg Gly Lys Ala Leu Arg Leu Thr Pro Pro Gly 
                645                 650                 655     


Asp Met Val Ala Leu Arg Ala Gly Glu Ala Asp Val Arg Asp Phe Leu 
            660                 665                 670         


Asn Arg Thr Gly Ala Ala Leu Asp Leu Ala Ala Val Asn Ser Pro Glu 
        675                 680                 685             


Ala Val Val Val Ser Gly Thr Pro Asp Ala Val Ala Asp Phe Arg Ala 
    690                 695                 700                 


Ala Trp Thr Ala Ser Gly Gly Gln Ala Arg Asn Leu Thr Val Arg His 
705                 710                 715                 720 


Ala Phe His Ser Arg His Val Glu Ser Ala Leu Asp Glu Phe Arg Thr 
                725                 730                 735     


Thr Leu Glu Thr Leu Thr Phe Arg Ala Pro Lys Val Pro Leu Val Ser 
            740                 745                 750         


Thr Ala Thr Gly Arg Leu Val Gly Pro Ala Glu Leu Gly Ala Pro Glu 
        755                 760                 765             


Tyr Trp Leu Arg Gln Val Arg Gln Thr Val Arg Phe Glu Asp Ala Leu 
    770                 775                 780                 


Arg Asp Leu Ser Gly Arg Gly Val Gly Thr Phe Val Glu Ile Gly Pro 
785                 790                 795                 800 


Ser Gly Ser Leu Ala Thr Ala Gly Leu Glu Cys Leu Gly Asp Asp Ala 
                805                 810                 815     


Ser Phe His Ala Val Gln Arg Pro Arg Ser Pro Glu Asp Val Cys Leu 
            820                 825                 830         


Met Thr Ala Val Ala Glu Leu His Ala Gly Gly Thr Thr Val Asp Trp 
        835                 840                 845             


Ala Lys Val Leu Ala Gly Gly Arg Thr Val Asp Leu Pro Val Tyr Pro 
    850                 855                 860                 


Phe Gln His Arg Pro Tyr Trp Ile Ala Pro Ala Ser Tyr Pro Asp Glu 
865                 870                 875                 880 


Pro Arg Thr Met Arg Glu Leu Val Arg Leu Glu Val Ala Gly Ile Leu 
                885                 890                 895     


Gly Leu Ser Asp Pro Ser Val Ile Leu Asp Asp Ser Ser Phe Leu Glu 
            900                 905                 910         


Leu Gly Phe Asp Ser Leu Ser Ser Leu Arg Leu Gly Asn Arg Leu Ala 
        915                 920                 925             


Thr Val Thr Gly Leu Asp Leu Pro Ser Thr Leu Leu Phe Asp Tyr Ala 
    930                 935                 940                 


Thr Pro Ala Ala Leu Ala Thr His Leu Asp 
945                 950                 


<210>  105
<211>  906
<212>  PRT
<213>  Catellatospora ferruginea

<400>  105

Glu Pro Leu Ala Ile Val Gly Met Ala Cys Arg Leu Pro Gly Gly Val 
1               5                   10                  15      


Ser Thr Pro Glu Asp Leu Trp Arg Leu Val Glu Ser Gly Val Asp Ala 
            20                  25                  30          


Ile Ser Asp Phe Pro Ala Asp Arg Gly Trp Asp Val Ala Asn Leu Phe 
        35                  40                  45              


Asp Pro Asp Pro Asp Ala Pro Gly Lys Thr Tyr Ser Val Arg Gly Gly 
    50                  55                  60                  


Phe Leu Asp Thr Ala Ala Asp Phe Asp Ala Ala Phe Phe Gly Ile Ser 
65                  70                  75                  80  


Pro Arg Glu Ala Leu Ala Met Asp Pro Gln Gln Arg Leu Val Leu Glu 
                85                  90                  95      


Ala Ser Trp Glu Ala Phe Glu Arg Ala Gly Ile Glu Pro Ser Ser Val 
            100                 105                 110         


Arg Gly Ser Asp Thr Gly Val Phe Met Gly Ala Phe Ser Ala Gly Tyr 
        115                 120                 125             


Gly Thr Glu Leu Glu Gly Phe Gly Ala Thr Ala Gly Ala Val Ser Val 
    130                 135                 140                 


Leu Ser Gly Arg Val Ser Tyr Phe Phe Gly Leu Glu Gly Pro Ala Met 
145                 150                 155                 160 


Thr Val Asp Thr Ala Cys Ser Ser Ser Leu Val Ala Leu His Gln Ala 
                165                 170                 175     


Gly Tyr Ala Leu Arg Gln Gly Glu Cys Ser Leu Ala Leu Val Gly Gly 
            180                 185                 190         


Val Thr Val Met Ala Ser Pro Gln Ser Phe Val Glu Phe Ser Arg Gln 
        195                 200                 205             


Arg Gly Leu Ser Val Asp Gly Arg Cys Lys Ala Phe Ala Asp Ala Ala 
    210                 215                 220                 


Asp Gly Thr Gly Trp Ala Glu Gly Val Gly Val Leu Val Val Glu Arg 
225                 230                 235                 240 


Leu Ser Asp Ala Glu Ala Lys Gly His Arg Ile Gln Ala Met Val Arg 
                245                 250                 255     


Ser Ser Ala Val Asn Gln Asp Gly Ala Ser Asn Gly Leu Ser Ala Pro 
            260                 265                 270         


Asn Gly Pro Ser Gln Gln Arg Val Ile Arg Gln Ala Leu Ala Asn Ala 
        275                 280                 285             


Gly Leu Thr Gly Ala Asp Val Asp Val Val Glu Ala His Gly Thr Gly 
    290                 295                 300                 


Thr Thr Leu Gly Asp Pro Ile Glu Ala Gln Ala Leu Leu Ala Thr Tyr 
305                 310                 315                 320 


Gly Gln Asp Arg Glu Gln Pro Leu Leu Leu Gly Ser Leu Lys Ser Asn 
                325                 330                 335     


Val Gly His Thr Gln Ala Ala Ala Gly Val Ser Gly Val Ile Lys Met 
            340                 345                 350         


Val Met Ala Leu Gln His Gly Val Val Pro Arg Thr Leu His Val Asp 
        355                 360                 365             


Glu Pro Ser Arg His Val Asp Trp Ser Ala Gly Ala Val Glu Leu Val 
    370                 375                 380                 


Thr Gln Asn Gln Pro Trp Pro Ser Phe Asp Arg Pro Arg Arg Ala Gly 
385                 390                 395                 400 


Val Ser Ser Phe Gly Val Ser Gly Thr Asn Ala His Ile Ile Leu Glu 
                405                 410                 415     


Ser Ala Pro Ala Gln Pro Leu Ala Pro Ser Thr Pro Ile Pro Gly Leu 
            420                 425                 430         


Val Pro Leu Val Ile Ser Ala Lys Thr Ala Pro Ala Leu Thr Ala Phe 
        435                 440                 445             


Glu Ala Arg Leu Arg Asp Tyr Leu Thr Ala Asp Ala Asp Leu Thr Ala 
    450                 455                 460                 


Ile Ala Ala Thr Leu Ala Thr Thr Arg Ser Thr Phe Glu His Arg Ala 
465                 470                 475                 480 


Val Leu Leu Gly Asp Asp Thr Val Thr Gly Ile Ala Ala Pro Asp Pro 
                485                 490                 495     


Arg Val Val Phe Val Phe Pro Gly Gln Gly Trp Gln Trp Leu Gly Met 
            500                 505                 510         


Gly Ser Ala Leu Cys Glu Ser Ser Val Val Phe Ala Ser Arg Met Ala 
        515                 520                 525             


Glu Cys Ala Ala Ala Leu Ser Glu Phe Val Asp Trp Asp Leu Phe Ser 
    530                 535                 540                 


Val Leu Asp Asp Pro Ala Val Val Asp Arg Val Asp Val Val Gln Pro 
545                 550                 555                 560 


Ala Cys Trp Ala Val Met Val Ser Leu Ala Ala Thr Trp Gln Ala Ala 
                565                 570                 575     


Gly Val His Pro Asp Ala Val Val Gly His Ser Gln Gly Glu Ile Ala 
            580                 585                 590         


Ala Ala Cys Leu Ala Gly Ala Ile Ser Leu Gln Asp Gly Ala Arg Val 
        595                 600                 605             


Val Ala Leu Arg Ser Gln Leu Ile Ala Arg Leu Ala Gly His Gly Ala 
    610                 615                 620                 


Met Ala Ser Ile Ala Leu Pro Ala Asp Gln Ile Ala Leu Thr Asp Gly 
625                 630                 635                 640 


Ala Trp Ile Ala Ala Arg Asn Gly Pro Ala Ala Thr Val Ile Ala Gly 
                645                 650                 655     


Ala Pro Glu Ala Val Asp Ser Val Leu Ala Ala His Gly Asp Ala Arg 
            660                 665                 670         


Val Arg Arg Ile Thr Val Asp Tyr Ala Ser His Thr Pro His Val Glu 
        675                 680                 685             


Gln Ile Arg Ala Glu Leu Leu Ala Ile Leu Ala Asp Ile Asp Ser Arg 
    690                 695                 700                 


Pro Pro Ser Ile Pro Trp Leu Ser Thr Val Asp Asp Ala Leu Val Glu 
705                 710                 715                 720 


Gly Pro Leu Lys Ala Asp Tyr Trp Tyr Arg Asn Leu Arg Glu Pro Val 
                725                 730                 735     


Gly Phe Asp Thr Ala Val Ser Ala Leu Gln Asp Ala Val Phe Ile Glu 
            740                 745                 750         


Val Ser Ala Asn Pro Val Leu Leu Pro Ala Met Gly Asp Ala Ala Thr 
        755                 760                 765             


Val Ala Thr Leu Arg Arg Asp Asp Gly Gly Gln Asp Arg Leu Leu Thr 
    770                 775                 780                 


Ala Val Ala Glu Ala Tyr Val Gln Gly Val Ala Val Asp Trp Ala Ala 
785                 790                 795                 800 


Val Ile Gly Ala Thr Gly Ala Arg Val Leu Asp Leu Pro Thr Tyr Ala 
                805                 810                 815     


Phe Gln His Gln Arg Phe Trp Ala Arg Ala Ala Ser Ala Ala Gly Leu 
            820                 825                 830         


Ala Pro Glu Ala Leu Leu Lys Val Val Gln Asp Ser Ala Ala Gln Val 
        835                 840                 845             


Leu Gly Tyr Ala Asp Pro Gly Ala Ile Ala Val Thr Ala Ala Phe Lys 
    850                 855                 860                 


Asp Leu Gly Ile Asp Ser Leu Thr Ala Val Glu Met Arg Asn Thr Leu 
865                 870                 875                 880 


Ala Lys Lys Thr Gly Leu Arg Leu Pro Ala Thr Leu Val Phe Asp Tyr 
                885                 890                 895     


Pro Thr Pro Gly Val Leu Ala Gly Arg Leu 
            900                 905     


<210>  106
<211>  874
<212>  PRT
<213>  Catellatospora ferruginea

<400>  106

Glu Pro Leu Ala Ile Val Gly Met Ala Cys Arg Leu Pro Gly Gly Val 
1               5                   10                  15      


Ser Ser Pro Glu Asp Leu Trp Arg Leu Val Glu Ser Gly Gly Asp Ala 
            20                  25                  30          


Ile Ser Asp Phe Pro Ala Asp Arg Gly Trp Asp Ile Glu Asn Leu Phe 
        35                  40                  45              


Asp Pro Asp Pro Asp Ala Ala Gly Lys Thr Tyr Ser Val Arg Gly Gly 
    50                  55                  60                  


Phe Leu Asp Ala Ala Ala Gly Phe Asp Ala Ala Phe Phe Gly Ile Ser 
65                  70                  75                  80  


Pro Arg Glu Ala Leu Ala Met Asp Pro Gln Gln Arg Leu Val Leu Glu 
                85                  90                  95      


Ala Ser Trp Glu Ala Phe Glu Arg Ala Gly Ile Glu Pro Gly Ser Val 
            100                 105                 110         


Arg Gly Ser Asp Thr Gly Val Phe Met Gly Ala Tyr Pro Gly Gly Tyr 
        115                 120                 125             


Gly Thr Gly Ala Asp Val Gly Gly Phe Gly Ala Thr Ala Gly Ala Val 
    130                 135                 140                 


Ser Val Leu Ser Gly Arg Val Ser Tyr Phe Phe Gly Leu Glu Gly Pro 
145                 150                 155                 160 


Ala Met Thr Val Asp Thr Ala Cys Ser Ser Ser Leu Val Ala Leu His 
                165                 170                 175     


Gln Ala Gly His Ala Leu Arg Gln Gly Glu Cys Ser Leu Ala Leu Val 
            180                 185                 190         


Gly Gly Val Thr Val Met Ala Thr Pro His Thr Phe Ile Glu Phe Ser 
        195                 200                 205             


Arg Gln Gln Gly Leu Ala Ser Asp Gly Arg Ser Lys Ala Phe Ala Asp 
    210                 215                 220                 


Ala Ala Asp Gly Ala Gly Phe Ser Glu Gly Val Gly Val Leu Val Val 
225                 230                 235                 240 


Glu Arg Leu Ser Asp Ala Arg Ala Lys Gly His Arg Val Leu Ala Val 
                245                 250                 255     


Val Arg Ser Ser Ala Val Asn Gln Asp Gly Ala Ser Asn Gly Leu Thr 
            260                 265                 270         


Ala Pro Asn Gly Pro Ser Gln Gln Arg Val Ile Arg Gln Ala Leu Ala 
        275                 280                 285             


Asn Ala Gly Leu Thr Gly Ala Asp Val Asp Val Val Glu Ala His Gly 
    290                 295                 300                 


Thr Gly Thr Thr Leu Gly Asp Pro Ile Glu Ala Gln Ala Val Leu Ala 
305                 310                 315                 320 


Thr Tyr Gly Gln Asp Arg Gln Lys Pro Leu Leu Leu Gly Ser Leu Lys 
                325                 330                 335     


Ser Asn Val Gly His Thr Gln Ala Ala Ala Gly Val Ser Gly Val Ile 
            340                 345                 350         


Lys Met Val Met Ala Leu Gln His Gly Val Val Pro Arg Thr Leu His 
        355                 360                 365             


Val Asp Glu Pro Ser Arg His Val Asp Trp Ser Ala Gly Ala Val Glu 
    370                 375                 380                 


Leu Val Thr Glu Asn Gln Pro Trp Pro Ser Val Asp Arg Pro Arg Arg 
385                 390                 395                 400 


Ala Gly Val Ser Ser Phe Gly Ile Ser Gly Thr Asn Ala His Val Ile 
                405                 410                 415     


Leu Glu Ser Val Pro Val Gln Leu Pro Val Pro Ser Ala Gly Leu Ala 
            420                 425                 430         


Pro Leu Met Ile Ser Ala Lys Thr Ala Pro Ala Leu Gly Asp Ala Glu 
        435                 440                 445             


Ala Arg Leu Arg Gly Tyr Leu Thr Ala Asp Ala Asp Leu Pro Ala Ile 
    450                 455                 460                 


Ala Ser Thr Leu Ala Thr Thr Arg Ser Met Phe Glu His Arg Ala Val 
465                 470                 475                 480 


Leu Leu Gly Asp Thr Thr Ile Thr Gly Thr Ala Ala Ala Asp Pro Lys 
                485                 490                 495     


Val Val Phe Val Phe Ser Gly Gln Gly Ser Gln Arg Ala Gly Met Gly 
            500                 505                 510         


Glu Gln Leu Ala Phe Pro Val Phe Ala Asp Ile His Arg Arg Val Trp 
        515                 520                 525             


Asp Leu Leu Asp Val Pro Asp Leu Asp Val Asp Gln Thr Gly Tyr Ala 
    530                 535                 540                 


Gln Pro Ala Leu Phe Ala Leu Gln Val Ala Leu Ala Gly Leu Leu Glu 
545                 550                 555                 560 


Ser Trp Gly Val Arg Pro Gln Ala Val Ile Gly His Ser Val Gly Glu 
                565                 570                 575     


Leu Ala Ala Gly Tyr Val Ala Gly Leu Trp Ser Leu Glu Asp Ala Cys 
            580                 585                 590         


Thr Leu Val Ser Ala Arg Ala Arg Leu Met Gln Ala Leu Pro Pro Gly 
        595                 600                 605             


Gly Val Met Val Ala Val Pro Val Ser Glu Asp Gln Ala Arg Ala Ala 
    610                 615                 620                 


Leu Leu Glu Gly Val Glu Ile Ala Ala Val Asn Gly Pro Ser Ser Val 
625                 630                 635                 640 


Val Leu Ser Gly Asp Glu Thr Ala Val Leu Gln Val Ala Ala Gly Leu 
                645                 650                 655     


Gly Lys Trp Thr Arg Leu Ser Thr Ser His Ala Phe His Ser Ala Arg 
            660                 665                 670         


Met Glu Pro Met Leu Glu Glu Phe Arg Ala Val Ala Glu Gln Val Thr 
        675                 680                 685             


Tyr Arg Thr Pro Val Ile Thr Met Ala Ala Gly Ala Ala Thr Pro Asp 
    690                 695                 700                 


Tyr Trp Val Arg Gln Val Arg Asp Thr Val Arg Phe Gly Asp Gln Val 
705                 710                 715                 720 


Ala Ala Phe Glu Gly Ala Thr Phe Val Glu Ile Gly Pro Asp Arg Thr 
                725                 730                 735     


Leu Ala Arg Leu Val Asp Gly Ile Ala Met Leu His Gly Asp Asp Glu 
            740                 745                 750         


Val Glu Ala Ala Leu Thr Gly Leu Ala Arg Leu Phe Val Gln Gly Val 
        755                 760                 765             


Pro Val Ala Trp Asp Asn Gly Ala Arg Val Leu Asp Leu Pro Thr Tyr 
    770                 775                 780                 


Pro Phe Gln His Gln Arg Tyr Trp Leu Asp Ala Arg Arg Ala Ala Ser 
785                 790                 795                 800 


Ala Gly Gly Asp Leu Leu Lys Met Val Arg Asp Asn Ala Ala Leu Ile 
                805                 810                 815     


Leu Gly His Thr Asn Pro Gly Ala Ile Ser Glu Thr Thr Ala Phe Arg 
            820                 825                 830         


Asp Leu Gly Val Asp Ser Leu Thr Ala Val Gln Leu Arg Asn Ser Leu 
        835                 840                 845             


Ala Lys Ala Thr Gly Leu Arg Leu Pro Ala Thr Leu Val Phe Asp Tyr 
    850                 855                 860                 


Pro Thr Pro Ser Val Leu Ala Gly Arg Leu 
865                 870                 


<210>  107
<211>  870
<212>  PRT
<213>  Catellatospora ferruginea

<400>  107

Glu Pro Leu Ala Ile Val Gly Met Ala Cys Arg Leu Pro Gly Gly Val 
1               5                   10                  15      


Ser Ser Pro Glu Asp Leu Trp Arg Leu Val Glu Ser Gly Thr Asp Ala 
            20                  25                  30          


Ile Ser Asp Phe Pro Ala Asp Arg Gly Trp Asp Val Asp Asn Leu Phe 
        35                  40                  45              


Asp Pro Asp Pro Asp Ala Pro Gly Lys Thr Tyr Ser Val Gln Gly Gly 
    50                  55                  60                  


Phe Leu Asp Ala Ala Ala Glu Phe Asp Ala Ala Phe Phe Gly Ile Ser 
65                  70                  75                  80  


Pro Arg Glu Ala Leu Ala Met Asp Pro Gln Gln Arg Leu Val Leu Glu 
                85                  90                  95      


Ala Ser Trp Glu Ala Phe Glu Arg Ala Gly Ile Glu Pro Gly Ser Val 
            100                 105                 110         


Arg Gly Ser Asp Thr Gly Val Phe Met Gly Ala Tyr Ser Gly Gly Tyr 
        115                 120                 125             


Gly Ala Gly Ala Asp Leu Asp Gly Phe Gly Ala Thr Ala Gly Ala Gly 
    130                 135                 140                 


Ser Val Leu Ser Gly Arg Ile Ser Tyr Phe Phe Gly Leu Glu Gly Pro 
145                 150                 155                 160 


Ala Met Thr Val Asp Thr Ala Cys Ser Ser Ser Leu Val Ala Leu His 
                165                 170                 175     


Gln Ala Gly Ser Ala Leu Arg Gln Gly Glu Cys Ser Leu Ala Val Val 
            180                 185                 190         


Gly Gly Val Thr Val Met Ala Thr Pro Asp Leu Phe Val Glu Phe Ser 
        195                 200                 205             


Arg Gln Arg Gly Leu Ala Ala Asp Gly Arg Cys Lys Ala Phe Gly Asp 
    210                 215                 220                 


Ala Ala Asp Gly Thr Gly Trp Ala Glu Gly Val Gly Val Leu Leu Val 
225                 230                 235                 240 


Glu Arg Leu Ser Asp Ala Glu Ala Lys Gly His Arg Val Leu Ala Val 
                245                 250                 255     


Val Arg Ser Ser Ala Val Asn Gln Asp Gly Ala Ser Asn Gly Leu Thr 
            260                 265                 270         


Ala Pro Asn Gly Pro Ser Gln Gln Arg Val Ile Arg Ser Ala Leu Ala 
        275                 280                 285             


Thr Ala Gly Leu Ala Pro Gln Asp Val Asp Val Val Glu Ala His Gly 
    290                 295                 300                 


Thr Gly Thr Thr Leu Gly Asp Pro Ile Glu Ala Gln Ala Val Leu Ala 
305                 310                 315                 320 


Thr Tyr Gly Gln Asp Arg Glu Arg Pro Leu Leu Leu Gly Ser Leu Lys 
                325                 330                 335     


Ser Asn Val Gly His Thr Gln Ala Ala Ala Gly Val Ser Gly Val Ile 
            340                 345                 350         


Lys Met Val Met Ala Leu Gln His Gly Val Val Pro Arg Thr Leu His 
        355                 360                 365             


Val Asp Glu Pro Ser Arg His Val Asp Trp Ser Ala Gly Ala Val Glu 
    370                 375                 380                 


Leu Val Thr Gln Asn Gln Pro Trp Pro Asp Val Asp Arg Pro Arg Arg 
385                 390                 395                 400 


Ala Ala Val Ser Ala Phe Gly Val Ser Gly Thr Asn Ala His Val Ile 
                405                 410                 415     


Leu Glu Ser Val Pro Ala Val Pro Pro Val Pro Ser Ala Gly Pro Ala 
            420                 425                 430         


Pro Leu Met Ile Ser Ala Lys Thr Ala Pro Ala Leu Gly Asp Ala Glu 
        435                 440                 445             


Ala Arg Leu Arg Asp Tyr Leu Thr Ala Asp Ala Asp Leu Thr Ala Ile 
    450                 455                 460                 


Ala Ser Thr Leu Ala Thr Thr Arg Ser Thr Phe Glu His Arg Ser Val 
465                 470                 475                 480 


Ile Phe Glu Asn His Thr Ile Thr Gly Thr Ala Ala Pro Asp Pro Arg 
                485                 490                 495     


Val Val Phe Val Phe Ser Gly Gln Gly Ser Gln Arg Ala Gly Met Gly 
            500                 505                 510         


Glu Gln Leu Ala Ala Thr Phe Pro Val Phe Ala Glu Ile His Arg Arg 
        515                 520                 525             


Val Trp Asp Leu Leu Asp Gly Pro Asp Leu Asp Val Asp Gln Thr Gly 
    530                 535                 540                 


Tyr Ala Gln Pro Ala Leu Phe Ala Leu Gln Val Ala Leu Val Gly Leu 
545                 550                 555                 560 


Leu Glu Ser Trp Gly Val Arg Pro Glu Ala Val Ile Gly His Ser Val 
                565                 570                 575     


Gly Glu Leu Ala Ala Gly Tyr Val Ser Gly Leu Trp Ser Leu Glu Asp 
            580                 585                 590         


Ala Cys Thr Leu Val Ser Ala Arg Ala Arg Leu Met Gln Ala Leu Pro 
        595                 600                 605             


Pro Gly Gly Val Met Val Ala Val Pro Val Pro Glu Asp Gln Ala Arg 
    610                 615                 620                 


Ala Ala Leu Val Glu Gly Val Glu Ile Ala Ala Val Asn Gly Pro Ser 
625                 630                 635                 640 


Ser Val Val Leu Ser Gly Asp Glu Ala Ala Val Leu Gln Val Ala Ala 
                645                 650                 655     


Gly Leu Gly Lys Trp Thr Arg Leu Ala Thr Ser His Ala Phe His Ser 
            660                 665                 670         


Ala Arg Met Glu Pro Met Leu Glu Glu Phe Arg Gly Val Ala Glu Gln 
        675                 680                 685             


Leu Thr Tyr Arg Thr Pro Val Ile Ser Met Ala Ala Glu Val Ala Thr 
    690                 695                 700                 


Pro Asp Tyr Trp Val Arg Gln Val Arg Asp Thr Val Arg Phe Gly Asp 
705                 710                 715                 720 


Gln Val Ala Glu Phe Glu Gly Ala Thr Phe Val Glu Ile Gly Pro Asp 
                725                 730                 735     


Arg Thr Leu Ala Arg Leu Ile Asp Gly Ile Ala Met Leu His Gly Asp 
            740                 745                 750         


Asp Glu Val Glu Ala Ala Leu Asn Gly Leu Ala Arg Leu Phe Val Gln 
        755                 760                 765             


Gly Val Pro Val Ala Trp Asp Asn Gly Gly Arg Val Leu Asp Leu Pro 
    770                 775                 780                 


Thr Tyr Pro Phe Gln Arg Gln Arg Tyr Trp Ala Val Ser Pro Glu Ala 
785                 790                 795                 800 


Leu Leu Lys Ala Val Arg Asp Ser Ala Ala Met Ile Leu Gly His Ala 
                805                 810                 815     


Asp Pro Ser Ala Ile Ser Glu Thr Ala Ala Phe Arg Asp Leu Gly Val 
            820                 825                 830         


Asp Ser Leu Thr Ala Val Glu Leu Arg Asn Ser Leu Ala Lys Ala Thr 
        835                 840                 845             


Gly Leu Arg Leu Pro Ala Thr Leu Val Phe Asp Tyr Pro Thr Pro Ala 
    850                 855                 860                 


Val Leu Ala Ala Arg Leu 
865                 870 


<210>  108
<211>  875
<212>  PRT
<213>  Catellatospora ferruginea

<400>  108

Glu Pro Leu Ala Ile Val Gly Met Ala Cys Arg Leu Pro Gly Gly Val 
1               5                   10                  15      


Ser Ser Pro Glu Asp Leu Trp Arg Leu Val Glu Ser Gly Thr Asp Ala 
            20                  25                  30          


Ile Ser Asp Phe Pro Thr Asp Arg Gly Trp Asp Ala Ala Ser Leu Phe 
        35                  40                  45              


Asp Pro Asp Pro Asp Ala Ala Gly Lys Thr Tyr Ser Val Gln Gly Gly 
    50                  55                  60                  


Phe Leu Asp Ala Ala Ala Asp Phe Asp Ala Ala Phe Phe Gly Ile Ser 
65                  70                  75                  80  


Pro Arg Glu Ala Leu Ala Met Asp Pro Gln Gln Arg Leu Val Leu Glu 
                85                  90                  95      


Ala Ser Trp Glu Ala Phe Glu Arg Ala Gly Ile Glu Pro Gly Ser Val 
            100                 105                 110         


Arg Gly Thr Asp Thr Gly Val Phe Met Gly Ala Phe Ser Ala Gly Tyr 
        115                 120                 125             


Gly Ala Arg Leu Glu Gly Phe Gly Ala Thr Ala Gly Ala Val Ser Val 
    130                 135                 140                 


Leu Ser Gly Arg Val Ser Tyr Leu Phe Gly Leu Glu Gly Pro Ala Met 
145                 150                 155                 160 


Thr Val Asp Thr Ala Cys Ser Ser Ser Leu Val Ala Leu His Gln Ala 
                165                 170                 175     


Ala Tyr Ser Leu Arg Gln Gly Glu Cys Ser Leu Ala Leu Val Gly Gly 
            180                 185                 190         


Val Thr Val Met Ala Thr Pro Gln Ile Phe Val Asp Phe Ser Arg Gln 
        195                 200                 205             


Arg Gly Leu Ala Pro Asp Gly Arg Cys Lys Ala Phe Gly Asp Asn Ala 
    210                 215                 220                 


Asp Gly Thr Gly Trp Ala Glu Gly Val Gly Val Leu Val Val Glu Arg 
225                 230                 235                 240 


Leu Ser Asp Ala Gln Ala Lys Gly His Arg Val Leu Ala Val Val Arg 
                245                 250                 255     


Ser Ser Ala Val Asn Gln Asp Gly Ala Ser Asn Gly Leu Thr Ala Pro 
            260                 265                 270         


Asn Gly Pro Ser Gln Gln Arg Val Ile Arg Gln Ala Leu Ala Asn Ala 
        275                 280                 285             


Gly Leu Thr Ser Ala Asp Val Asp Val Val Glu Ala His Gly Thr Gly 
    290                 295                 300                 


Thr Thr Leu Gly Asp Pro Ile Glu Ala Gln Ala Val Leu Ala Thr Tyr 
305                 310                 315                 320 


Gly Gln Asp Arg Asp Arg Pro Leu Leu Leu Gly Ser Leu Lys Ser Asn 
                325                 330                 335     


Ile Gly His Thr Gln Ala Ala Ser Gly Val Ser Gly Val Ile Lys Met 
            340                 345                 350         


Val Met Ala Leu Gln His Gly Val Val Pro Pro Thr Leu His Ala Asp 
        355                 360                 365             


Gln Pro Ser Gln His Val Asp Trp Ser Thr Gly Ala Val Glu Leu Val 
    370                 375                 380                 


Thr Gln Ser Gln Pro Trp Pro Ser Val Asp Arg Pro Arg Arg Ala Gly 
385                 390                 395                 400 


Val Ser Ser Phe Gly Ile Ser Gly Thr Asn Ala His Val Ile Leu Glu 
                405                 410                 415     


Ser Val Pro Ala Gln Pro Pro Val Pro Ser Ala Gly Pro Ala Pro Leu 
            420                 425                 430         


Met Ile Ser Ala Lys Thr Ala Pro Ala Leu Gly Glu Ala Glu Ala Arg 
        435                 440                 445             


Leu Arg Asp Tyr Leu Thr Ala Asp Ala Asp Leu Pro Ala Ile Ala Ser 
    450                 455                 460                 


Thr Leu Ala Thr Thr Arg Ser Ile Phe Glu His Arg Ala Val Leu Leu 
465                 470                 475                 480 


Gly Asp Thr Thr Ile Thr Gly Thr Ala Ala Ala Asp Pro Lys Val Val 
                485                 490                 495     


Phe Val Phe Ser Gly Gln Gly Ser Gln Arg Ala Gly Met Gly Glu Gln 
            500                 505                 510         


Leu Ala Phe Pro Val Phe Ala Asp Ile His Arg Arg Val Trp Asp Leu 
        515                 520                 525             


Leu Asp Val Pro Asp Leu Asp Val Asp Gln Thr Gly Tyr Ala Gln Pro 
    530                 535                 540                 


Ala Leu Phe Ala Leu Gln Val Ala Leu Ala Gly Leu Leu Glu Ser Trp 
545                 550                 555                 560 


Gly Val Arg Pro Gln Ala Val Ile Gly His Ser Val Gly Glu Leu Ala 
                565                 570                 575     


Ala Gly Tyr Val Ala Gly Leu Trp Ser Leu Glu Asp Ala Cys Thr Leu 
            580                 585                 590         


Val Ser Ala Arg Ala Arg Leu Met Gln Ala Leu Pro Pro Gly Gly Val 
        595                 600                 605             


Met Val Ala Val Pro Val Ser Glu Glu Gln Ala Arg Ala Ala Leu Thr 
    610                 615                 620                 


Glu Gly Val Glu Ile Ala Ala Val Asn Gly Pro Ser Ser Val Val Leu 
625                 630                 635                 640 


Ser Gly Asp Glu Thr Ala Val Leu Gln Val Ala Ala Gly Leu Gly Lys 
                645                 650                 655     


Trp Thr Arg Leu Ser Thr Ser His Ala Phe His Ser Ala Arg Met Glu 
            660                 665                 670         


Pro Met Leu Glu Glu Phe Arg Ala Val Ala Glu Gln Leu Thr Tyr Arg 
        675                 680                 685             


Thr Pro Thr Ile Thr Met Thr Glu Glu Val Thr Thr Pro Asp Tyr Trp 
    690                 695                 700                 


Val Arg Gln Val Arg Asp Thr Val Arg Phe Gly Asp Gln Val Ala Ala 
705                 710                 715                 720 


Phe Glu Gly Ala Thr Phe Val Glu Ile Gly Pro Asp Arg Thr Leu Ala 
                725                 730                 735     


Arg Leu Ile Asp Gly Ile Ala Met Leu His Gly Asp Asp Glu Thr Glu 
            740                 745                 750         


Ala Ala Leu Thr Gly Leu Ala Arg Leu Phe Val Gln Gly Val Pro Val 
        755                 760                 765             


Thr Trp Asp Asn Lys Ala Arg Val Leu Asp Leu Pro Thr Tyr Pro Phe 
    770                 775                 780                 


Gln Arg Gln Arg Tyr Trp Ala Gly Trp Leu Ala Gly Leu Ala Ala Glu 
785                 790                 795                 800 


Glu Arg Asp Lys Ala Leu Val Thr Val Val Arg Asp Ser Val Ala Ala 
                805                 810                 815     


Val Leu Gly Tyr Ala Asp Ser Arg Lys Ile Pro Val Ser Ala Ala Phe 
            820                 825                 830         


Lys Asp Leu Gly Val Asp Ser Leu Thr Ala Val Glu Leu Arg Asn Ser 
        835                 840                 845             


Leu Ala Lys Thr Thr Gly Leu Arg Leu Pro Ala Thr Leu Val Phe Asp 
    850                 855                 860                 


His Pro Thr Leu Ala Thr Leu Ala Ala Arg Leu 
865                 870                 875 


<210>  109
<211>  901
<212>  PRT
<213>  Catellatospora ferruginea

<400>  109

Glu Pro Leu Ala Ile Val Gly Val Ala Cys Arg Leu Pro Gly Gly Val 
1               5                   10                  15      


Ser Ser Pro Glu Ala Leu Trp Gln Leu Val Glu Ser Gly Thr Asp Ala 
            20                  25                  30          


Ile Ser Gly Phe Pro Ala Asp Arg Gly Trp Asp Val Asp Asn Leu Phe 
        35                  40                  45              


Asp Pro Asp Pro Glu Ala Ser Gly Lys Thr Tyr Cys Val Gln Gly Gly 
    50                  55                  60                  


Phe Leu Asp Ala Val Ala Glu Phe Asp Ala Ser Phe Phe Gly Ile Ser 
65                  70                  75                  80  


Pro Arg Glu Ala Leu Ala Met Asp Pro Gln Gln Arg Leu Ile Leu Glu 
                85                  90                  95      


Val Ser Trp Glu Ala Phe Glu Arg Ala Gly Ile Glu Pro Gly Ser Val 
            100                 105                 110         


Arg Gly Ser Asn Thr Gly Val Phe Met Gly Ala Phe Gly Ser Gly Tyr 
        115                 120                 125             


Gly Ser Asp Leu Glu Gly Phe Ser Ala Thr Ala Gly Ala Gly Ser Val 
    130                 135                 140                 


Leu Ser Gly Arg Ile Ser Tyr Phe Phe Gly Leu Glu Gly Pro Ala Met 
145                 150                 155                 160 


Thr Ile Asp Thr Ala Cys Ser Ser Ser Leu Val Ala Leu His Gln Ala 
                165                 170                 175     


Gly Tyr Ala Leu Arg Gln Gly Glu Cys Ser Leu Ala Leu Val Gly Gly 
            180                 185                 190         


Ala Thr Val Met Ala Thr Pro Gln Thr Phe Ile Glu Phe Ser Arg Gln 
        195                 200                 205             


Arg Gly Leu Ala Ala Asp Gly Arg Cys Lys Ser Phe Gly Asp Asn Ala 
    210                 215                 220                 


Asp Gly Thr Gly Trp Ser Glu Gly Val Gly Ala Leu Leu Val Glu Arg 
225                 230                 235                 240 


Leu Ser Asp Ala Gln Ala Lys Gly His Arg Val Leu Ala Val Val Arg 
                245                 250                 255     


Gly Ser Ala Val Asn Gln Asp Gly Ala Ser Asn Gly Leu Thr Ala Pro 
            260                 265                 270         


Asn Gly Pro Ser Gln Gln Arg Val Ile Arg Gln Ala Leu Ala Asn Ala 
        275                 280                 285             


Gly Leu Ala Pro Gln Asp Val Asp Val Val Glu Ala His Gly Thr Gly 
    290                 295                 300                 


Thr Arg Leu Gly Asp Pro Ile Glu Ala Gln Ala Val Leu Ala Thr Tyr 
305                 310                 315                 320 


Gly Gln Asp Arg Glu Arg Pro Leu Leu Leu Gly Ser Leu Lys Ser Asn 
                325                 330                 335     


Val Gly His Thr Gln Ala Ala Ala Gly Val Ser Gly Val Ile Lys Met 
            340                 345                 350         


Val Met Ala Leu Gln His Gly Val Val Pro Gln Thr Leu His Val Asp 
        355                 360                 365             


Glu Pro Ser Arg Gln Val Asp Trp Ser Ala Gly Ala Val Glu Leu Val 
    370                 375                 380                 


Thr Glu Asn Gln Pro Trp Pro Asp Val Asp Arg Pro Arg Arg Ala Ala 
385                 390                 395                 400 


Val Ser Ala Phe Gly Val Ser Gly Thr Asn Ala His Val Ile Leu Glu 
                405                 410                 415     


Ser Ala Pro Ala Gln Pro Val Ala Pro Ser Thr Pro Ala Thr Gly Leu 
            420                 425                 430         


Thr Pro Leu Val Ile Ser Ala Lys Thr Ala Pro Ala Leu Thr Ala Ser 
        435                 440                 445             


Glu Ala Arg Leu Arg Asp Tyr Leu Thr Ala Asp Ala Asp Leu Thr Ala 
    450                 455                 460                 


Ile Ala Ala Thr Leu Ala Ala Thr Arg Ser Ala Phe Glu His Arg Ala 
465                 470                 475                 480 


Val Leu Leu Gly Asp Asp Thr Val Thr Gly Ile Ala Ala Pro Asp Pro 
                485                 490                 495     


Arg Val Val Phe Val Phe Pro Gly Gln Gly Trp Gln Trp Leu Gly Met 
            500                 505                 510         


Gly Ser Ala Leu Arg Asp Ser Ser Val Val Phe Ala Glu Arg Met Ala 
        515                 520                 525             


Glu Cys Ala Ala Ala Leu Ser Asp Tyr Val Asp Trp Asp Leu Phe Ser 
    530                 535                 540                 


Val Leu Asp Asp Pro Ala Val Val Asp Arg Val Asp Val Val Gln Pro 
545                 550                 555                 560 


Ala Cys Trp Ala Val Met Val Ser Leu Ala Ala Thr Trp Gln Ala Ala 
                565                 570                 575     


Gly Val Arg Pro Asp Ala Val Val Gly His Ser Gln Gly Glu Ile Ala 
            580                 585                 590         


Ala Ala Cys Val Ala Gly Ala Ile Ser Leu Arg Asp Gly Ala Lys Ile 
        595                 600                 605             


Val Ala Leu Arg Ser Gln Leu Ile Ala Arg Leu Ala Gly His Gly Ala 
    610                 615                 620                 


Met Ala Ser Ile Ala Leu Pro Ala Asp Gln Ile Thr Leu Thr Asp Gly 
625                 630                 635                 640 


Val Trp Ile Ala Ala Arg Asn Gly Pro Ala Ala Thr Val Ile Ala Gly 
                645                 650                 655     


Ala Pro Glu Ala Val Asp Ser Val Leu Ser Ala His Gly Asp Ala Arg 
            660                 665                 670         


Val Arg Arg Ile Ala Val Asp Tyr Ala Ser His Thr Pro His Val Glu 
        675                 680                 685             


Gln Ile Arg Thr Glu Leu Leu Pro Ile Leu Ala Asp Ile Asp Ser Gln 
    690                 695                 700                 


Thr Pro Arg Ile Pro Trp Leu Ser Thr Val Asp Asp Thr Trp Ile Glu 
705                 710                 715                 720 


Gly Pro Leu Gly Ala Asp Tyr Trp Tyr Arg Asn Leu Arg Glu Gln Val 
                725                 730                 735     


Gly Phe Asp Thr Ala Val Glu His Leu Gln Asp Ser Val Phe Ile Glu 
            740                 745                 750         


Val Ser Ala Ser Pro Val Leu Leu Pro Ala Met Gly Asp Ala Ile Thr 
        755                 760                 765             


Val Ala Thr Leu Arg Arg Asp Glu Gly Gly Gln Asp Arg Leu Val Thr 
    770                 775                 780                 


Ala Leu Ala Glu Ala Tyr Val Gln Gly Val Pro Val Asp Trp Ala Ala 
785                 790                 795                 800 


Val Ile Asp Asn Thr Thr Ala Arg Val Leu Asp Leu Pro Thr Tyr Ala 
                805                 810                 815     


Phe Gln His Gln Arg Phe Trp Val Ala Asn Leu Thr Pro Glu Ala Leu 
            820                 825                 830         


Leu Lys Ala Val Arg Asp Ser Ala Ala Thr Val Leu Gly His Ala Asp 
        835                 840                 845             


Pro Gly Thr Ile Pro Glu Thr Ala Ala Phe Lys Asp Leu Gly Ile Asp 
    850                 855                 860                 


Ser Leu Thr Ala Val Glu Leu Arg Asn Ser Leu Ala Lys Thr Thr Gly 
865                 870                 875                 880 


Leu Arg Leu Pro Ala Thr Leu Val Phe Asp Tyr Pro Thr Pro Gly Val 
                885                 890                 895     


Leu Ala Ala Arg Leu 
            900     


<210>  110
<211>  882
<212>  PRT
<213>  Catellatospora ferruginea

<400>  110

Glu Pro Leu Ala Ile Val Gly Met Ala Cys Arg Leu Pro Gly Gly Val 
1               5                   10                  15      


Ser Ser Pro Glu Asp Leu Trp Arg Leu Val Glu Ser Gly Gly Asp Ala 
            20                  25                  30          


Ile Ser Asp Phe Pro Val Asp Arg Gly Trp Asp Val Asp Asn Leu Phe 
        35                  40                  45              


Asp Pro Asp Pro Asp Ala Ala Gly Lys Thr Tyr Ser Val Gln Gly Gly 
    50                  55                  60                  


Phe Leu Asp Thr Ala Ala Glu Phe Asp Ala Ala Phe Phe Gly Ile Ser 
65                  70                  75                  80  


Pro Arg Glu Ala Leu Ala Met Asp Pro Gln Gln Arg Leu Val Leu Glu 
                85                  90                  95      


Ala Ser Trp Glu Val Phe Glu Arg Ala Gly Ile Glu Pro Gly Ser Val 
            100                 105                 110         


Arg Gly Ser Asp Thr Gly Val Phe Met Gly Ala Tyr Pro Gly Tyr Tyr 
        115                 120                 125             


Gly Ile Gly Ala Asp Leu Asp Gly Phe Gly Ala Thr Ala Gly Ala Gly 
    130                 135                 140                 


Ser Val Leu Ser Gly Arg Val Ser Tyr Phe Phe Gly Leu Glu Gly Pro 
145                 150                 155                 160 


Ala Met Thr Val Asp Thr Ala Cys Ser Ser Ser Leu Val Ala Leu His 
                165                 170                 175     


Gln Ala Gly Ser Ala Leu Arg Gln Gly Glu Cys Ser Leu Ala Leu Val 
            180                 185                 190         


Gly Gly Val Thr Val Met Ala Thr Pro Gln Thr Tyr Val Glu Phe Ser 
        195                 200                 205             


Arg Gln Arg Gly Leu Ala Ser Asp Gly Arg Ser Lys Ala Phe Ala Asp 
    210                 215                 220                 


Ala Ala Asp Gly Ala Gly Phe Ser Glu Gly Val Gly Val Leu Leu Val 
225                 230                 235                 240 


Glu Arg Leu Ser Asp Ala Arg Arg His Gly His Arg Val Leu Ala Val 
                245                 250                 255     


Val Arg Ser Ser Ala Val Asn Gln Asp Gly Ala Ser Asn Gly Leu Thr 
            260                 265                 270         


Ala Pro Asn Gly Pro Ser Gln Gln Arg Val Ile Arg Gln Ala Leu Ala 
        275                 280                 285             


Thr Ala Gly Leu Ser Pro His Glu Val Asp Val Val Glu Ala His Gly 
    290                 295                 300                 


Thr Gly Thr Thr Leu Gly Asp Pro Ile Glu Ala Gln Ala Val Leu Ala 
305                 310                 315                 320 


Thr Tyr Gly Gln Asp Arg Asp Arg Pro Leu Leu Leu Gly Ser Val Lys 
                325                 330                 335     


Ser Asn Ile Gly His Thr Gln Ala Ala Ala Gly Val Ser Gly Val Ile 
            340                 345                 350         


Lys Met Val Met Ala Leu Gln His Gly Val Val Pro Pro Thr Leu His 
        355                 360                 365             


Val Asp Glu Pro Ser Arg His Val Asp Trp Ser Ala Gly Ala Val Asp 
    370                 375                 380                 


Leu Val Thr Glu Asn Arg Pro Trp Pro Asp Leu Asp Arg Pro Arg Arg 
385                 390                 395                 400 


Ala Gly Val Ser Ser Phe Gly Ile Ser Gly Thr Asn Ala His Val Ile 
                405                 410                 415     


Leu Glu Ser Val Pro Ala Val Pro Pro Val Pro Ser Ala Gly Pro Ala 
            420                 425                 430         


Pro Leu Met Ile Ser Ala Lys Thr Ala Pro Ala Leu Gly Glu Ala Glu 
        435                 440                 445             


Ala Arg Leu Arg Asp Tyr Leu Thr Ala Asp Ala Asp Leu Pro Ala Ile 
    450                 455                 460                 


Ala Ser Thr Leu Ala Ser Thr Arg Ser Thr Phe Glu His Arg Ala Val 
465                 470                 475                 480 


Ile Phe Gln Asn His Thr Ile Thr Gly Thr Ala Ala Ala Asp Pro Arg 
                485                 490                 495     


Val Val Phe Val Phe Ser Gly Gln Gly Ser Gln Arg Ala Gly Met Gly 
            500                 505                 510         


Glu Gln Leu Ala Ala Thr Phe Pro Val Phe Lys Asp Ile His Arg Arg 
        515                 520                 525             


Val Trp Asp Leu Leu Asp Val Pro Asp Leu Asp Val Asp Gln Thr Gly 
    530                 535                 540                 


Tyr Ala Gln Pro Ala Leu Phe Ala Leu Gln Val Ala Leu Phe Gly Leu 
545                 550                 555                 560 


Leu Glu Ser Trp Gly Val Arg Pro Glu Ala Val Ile Gly His Ser Val 
                565                 570                 575     


Gly Glu Leu Ala Ala Gly Tyr Val Ala Gly Leu Trp Ser Leu Glu Asp 
            580                 585                 590         


Ala Cys Thr Leu Val Ser Ala Arg Ala Arg Leu Met Gln Ala Leu Pro 
        595                 600                 605             


Pro Gly Gly Val Met Val Ala Val Ala Val Ser Glu Glu His Ala Gln 
    610                 615                 620                 


Ala Ala Leu Ile Lys Gly Val Glu Ile Ala Ala Val Asn Gly Pro Ser 
625                 630                 635                 640 


Ser Val Val Leu Ser Gly Asp Glu Thr Ala Val Leu Gln Val Ala Ala 
                645                 650                 655     


Gly Leu Gly Lys Trp Thr Arg Leu Ser Thr Ser His Ala Phe His Ser 
            660                 665                 670         


Ala Arg Met Glu Pro Met Leu Glu Lys Phe Arg Ala Val Ala Glu Gln 
        675                 680                 685             


Leu Thr Tyr Arg Thr Pro Val Ile Thr Met Ala Ala Glu Val Thr Thr 
    690                 695                 700                 


Pro Asp Tyr Trp Val Arg Gln Val Arg Asp Thr Val Arg Phe Gly Asp 
705                 710                 715                 720 


Gln Val Ala Ala Phe Glu Gly Ala Thr Phe Val Glu Ile Gly Pro Asp 
                725                 730                 735     


Arg Thr Leu Ala Arg Leu Val Asp Gly Ile Ala Met Leu His Gly Asp 
            740                 745                 750         


Asp Glu Val Glu Ala Ala Leu Thr Gly Leu Ala Arg Leu Phe Val Gln 
        755                 760                 765             


Gly Val Pro Val Thr Trp Asp Asn Gly Gly Arg Val Leu Asp Leu Pro 
    770                 775                 780                 


Thr Tyr Ala Phe Gln Arg Gln Arg Tyr Trp Ala Thr Ser Thr Arg Trp 
785                 790                 795                 800 


Leu Ala Gly Leu Thr Pro Gln Glu Arg Glu Asn Ala Leu Leu Lys Val 
                805                 810                 815     


Val Arg Asp Asn Ala Ala Val Val Leu Gly His Ala Gly Ala Gly Ala 
            820                 825                 830         


Ile Pro Ala Thr Ala Ala Phe Arg Asp Leu Gly Val Asp Ser Leu Thr 
        835                 840                 845             


Ala Val Glu Leu Arg Asn Ser Leu Ala Thr Thr Thr Gly Leu Arg Leu 
    850                 855                 860                 


Pro Ala Thr Met Val Phe Asp Tyr Pro Thr Pro Ala Ala Val Ala Ala 
865                 870                 875                 880 


Arg Leu 
        


<210>  111
<211>  902
<212>  PRT
<213>  Catellatospora sp.

<400>  111

Glu Pro Leu Ala Ile Val Gly Met Ala Cys Arg Leu Pro Gly Gly Val 
1               5                   10                  15      


Ser Ser Pro Glu Asp Leu Trp Arg Leu Val Glu Ser Gly Thr Asp Ala 
            20                  25                  30          


Ile Ser Asp Phe Pro Thr Asp Arg Gly Trp Asp Val Glu Ser Leu Phe 
        35                  40                  45              


Asp Pro Asp Pro Asp Ala Ala Gly Lys Thr Tyr Ser Val Arg Gly Gly 
    50                  55                  60                  


Phe Leu Asp Ala Ala Ala Ser Phe Asp Ala Ala Phe Phe Gly Ile Ser 
65                  70                  75                  80  


Pro Arg Glu Ala Leu Ala Met Asp Pro Gln Gln Arg Leu Val Leu Glu 
                85                  90                  95      


Ala Ser Trp Glu Ala Phe Glu Arg Ala Gly Ile Glu Pro Ser Ser Val 
            100                 105                 110         


Arg Gly Ser Asp Thr Gly Val Phe Met Gly Ala Phe Ser Ala Gly Tyr 
        115                 120                 125             


Gly Thr Glu Leu Glu Gly Phe Gly Val Thr Ala Gly Ala Val Ser Val 
    130                 135                 140                 


Leu Ser Gly Arg Val Ser Tyr Phe Phe Gly Leu Glu Gly Pro Ala Met 
145                 150                 155                 160 


Thr Val Asp Thr Ala Cys Ser Ser Ser Leu Val Ala Leu His Gln Ala 
                165                 170                 175     


Gly Tyr Ala Leu Arg Gln Gly Glu Cys Ser Leu Ala Leu Val Gly Gly 
            180                 185                 190         


Val Thr Val Met Ala Ser Pro Gln Ser Phe Val Glu Phe Ser Arg Gln 
        195                 200                 205             


Arg Gly Leu Ser Val Asp Gly Arg Cys Lys Ala Phe Ala Asp Ala Ala 
    210                 215                 220                 


Asp Gly Thr Gly Trp Ala Glu Gly Val Gly Val Leu Val Val Glu Arg 
225                 230                 235                 240 


Leu Ser Asp Ala Gln Ala Lys Gly His Arg Val Leu Ala Val Val Arg 
                245                 250                 255     


Ser Ser Ala Val Asn Gln Asp Gly Ala Ser Asn Gly Leu Ser Ala Pro 
            260                 265                 270         


Asn Gly Pro Ser Gln Gln Arg Val Ile Arg Gln Ala Leu Ala Asn Ala 
        275                 280                 285             


Gly Leu Thr Gly Ala Asp Val Asp Val Val Glu Ala His Gly Thr Gly 
    290                 295                 300                 


Thr Thr Leu Gly Asp Pro Ile Glu Ala Gln Ala Val Leu Ala Thr Tyr 
305                 310                 315                 320 


Gly Gln Asp Arg Glu Gln Pro Leu Leu Leu Gly Ser Leu Lys Ser Asn 
                325                 330                 335     


Ile Gly His Thr Gln Ala Ala Ala Gly Val Ser Gly Val Ile Lys Met 
            340                 345                 350         


Val Met Ala Leu Gln His Gly Val Val Pro Arg Thr Leu His Ile Asp 
        355                 360                 365             


Glu Pro Ser Gln His Val Asp Trp Ser Ala Gly Ala Val Glu Leu Val 
    370                 375                 380                 


Thr Gln Asn Gln Pro Trp Pro Gly Asn Asp Arg Pro Arg Arg Ala Gly 
385                 390                 395                 400 


Val Ser Ser Phe Gly Val Ser Gly Thr Asn Ala His Val Ile Leu Glu 
                405                 410                 415     


Ser Ala Pro Thr Gln Pro Ala Leu Pro Ser Val Thr Ala Thr Gly Pro 
            420                 425                 430         


Val Pro Leu Val Ile Ser Ala Lys Thr Ala Pro Ala Leu Thr Ala Phe 
        435                 440                 445             


Glu Ala Arg Leu Arg Asp Tyr Leu Thr Ala Asp Ala Asp Leu Thr Ala 
    450                 455                 460                 


Ile Ala Ala Thr Leu Ala Thr Thr Arg Ala Thr Phe Asp His Arg Ala 
465                 470                 475                 480 


Val Leu Leu Gly Asp Asp Thr Val Thr Gly Val Ala Val Pro Glu Pro 
                485                 490                 495     


Arg Val Val Phe Val Phe Pro Gly Gln Gly Trp Gln Trp Leu Gly Met 
            500                 505                 510         


Gly Ser Ala Leu Ser Glu Ser Ser Val Val Phe Ala Glu Arg Met Ala 
        515                 520                 525             


Glu Cys Ala Thr Ala Leu Asp Glu Phe Val Asp Trp Asp Leu Phe Ser 
    530                 535                 540                 


Val Leu Asp Asp Pro Ala Val Val Asp Arg Val Asp Val Val Gln Pro 
545                 550                 555                 560 


Ala Cys Trp Ala Val Met Val Ser Leu Ala Ala Thr Trp Gln Ala Ala 
                565                 570                 575     


Gly Val His Pro Asp Ala Val Ile Gly His Ser Gln Gly Glu Ile Ala 
            580                 585                 590         


Ala Ala Cys Val Ala Gly Ala Ile Ser Leu Arg Asp Gly Ala Arg Ile 
        595                 600                 605             


Val Ala Leu Arg Ser Gln Leu Ile Ala Arg Leu Ala Gly His Gly Ala 
    610                 615                 620                 


Met Ala Ser Ile Ala Leu Pro Ala Asp Gln Ile Thr Leu Thr Asp Gly 
625                 630                 635                 640 


Val Trp Ile Ala Ala Arg Asn Gly Pro Ala Ala Thr Val Ile Ala Gly 
                645                 650                 655     


Asp Pro Ala Ala Val Asp Ser Val Leu Ala Ala His Gln Asp Ala Arg 
            660                 665                 670         


Val Arg Arg Ile Thr Val Asp Tyr Ala Ser His Thr Pro His Val Glu 
        675                 680                 685             


Gln Ile Arg Ala Glu Leu Leu Ala Ile Leu Ser Asp Ile Gly Ser Gln 
    690                 695                 700                 


Thr Pro Val Ile Pro Trp Leu Ser Thr Val Asp Gly Glu Trp Val Glu 
705                 710                 715                 720 


Gly Pro Leu Gly Asn Asp Tyr Trp Tyr Arg Asn Leu Arg Glu Thr Val 
                725                 730                 735     


Gly Phe Asp Thr Ala Val Gly Leu Leu Pro Asp Ser Val Phe Ile Glu 
            740                 745                 750         


Val Ser Ala Ser Pro Val Leu Leu Pro Ala Met Gly Asp Ala Val Thr 
        755                 760                 765             


Val Ala Thr Leu Arg Arg Asp Asp Gly Gly Leu Thr Arg Leu Leu Thr 
    770                 775                 780                 


Ala Leu Ala Glu Ala Trp Val Gln Gly Val Ala Val Asp Trp Ala Ile 
785                 790                 795                 800 


Gly Ala Thr Thr Ala Arg Val Leu Asp Leu Pro Thr Tyr Ala Phe Gln 
                805                 810                 815     


His Gln His Tyr Trp Ala Val Thr Gly Thr Gly Leu Thr Pro Glu Ala 
            820                 825                 830         


Leu Leu Lys Val Val Gln Asp Ser Thr Ala Gln Val Leu Gly Tyr Thr 
        835                 840                 845             


Asp Ala Ala Ala Ile Ala Val Thr Ala Ala Phe Lys Asp Leu Gly Ile 
    850                 855                 860                 


Asp Ser Leu Thr Ala Val Glu Met Arg Asn Thr Leu Ala Lys Ala Thr 
865                 870                 875                 880 


Gly Leu Arg Leu Pro Ala Thr Leu Val Phe Asp Tyr Pro Thr Pro Ser 
                885                 890                 895     


Leu Leu Ala Gly Arg Leu 
            900         


<210>  112
<211>  888
<212>  PRT
<213>  Catellatospora sp.

<400>  112

Glu Pro Leu Ala Ile Val Gly Met Ala Cys Arg Leu Pro Gly Gly Val 
1               5                   10                  15      


Ser Ser Pro Glu Asp Leu Trp Arg Leu Val Glu Ser Gly Thr Asp Ala 
            20                  25                  30          


Ile Ser Asp Phe Pro Thr Asp Arg Gly Trp Asp Val Glu Ser Leu Phe 
        35                  40                  45              


Asp Pro Asp Pro Asp Ala Ala Gly Lys Thr Tyr Ser Val Arg Gly Gly 
    50                  55                  60                  


Phe Leu Asp Ala Ala Ala Gly Phe Asp Ala Ala Phe Phe Gly Ile Ser 
65                  70                  75                  80  


Pro Arg Glu Ala Leu Ala Met Asp Pro Gln Gln Arg Leu Val Leu Glu 
                85                  90                  95      


Ala Ser Trp Glu Ala Phe Glu Arg Ala Gly Ile Glu Pro Gly Ser Val 
            100                 105                 110         


Arg Gly Ser Asp Thr Gly Val Phe Met Gly Ala Tyr Pro Gly Gly Tyr 
        115                 120                 125             


Gly Thr Gly Val Asp Val Gly Gly Phe Gly Ala Thr Ala Gly Ala Val 
    130                 135                 140                 


Ser Val Leu Ser Gly Arg Val Ser Tyr Phe Phe Gly Leu Glu Gly Pro 
145                 150                 155                 160 


Ala Met Thr Val Asp Thr Ala Cys Ser Ser Ser Leu Val Ala Leu His 
                165                 170                 175     


Gln Ala Gly His Ala Leu Arg Gln Gly Glu Cys Ser Leu Ala Leu Val 
            180                 185                 190         


Gly Gly Val Thr Val Met Ala Thr Pro His Thr Phe Ile Glu Phe Ser 
        195                 200                 205             


Arg Gln Gln Gly Leu Ala Ser Asp Gly Arg Ser Lys Ala Phe Ala Asp 
    210                 215                 220                 


Ala Ala Asp Gly Ala Gly Phe Ser Glu Gly Val Gly Val Leu Val Val 
225                 230                 235                 240 


Glu Arg Leu Ser Asp Ala Gln Ala Lys Gly His Arg Val Leu Ala Val 
                245                 250                 255     


Val Arg Ser Ser Ala Val Asn Gln Asp Gly Ala Ser Asn Gly Leu Thr 
            260                 265                 270         


Ala Pro Asn Gly Pro Ser Gln Gln Arg Val Ile Arg Gln Ala Leu Ala 
        275                 280                 285             


Asp Ala Gly Leu Val Ser Ala Asp Val Asp Val Val Glu Ala His Gly 
    290                 295                 300                 


Thr Gly Thr Thr Leu Gly Asp Pro Ile Glu Ala Gln Ala Val Leu Ala 
305                 310                 315                 320 


Thr Tyr Gly Gln Asp Arg Glu His Pro Leu Leu Leu Gly Ser Leu Lys 
                325                 330                 335     


Ser Asn Val Gly His Thr Gln Ala Ala Ala Gly Val Ser Gly Val Ile 
            340                 345                 350         


Lys Met Val Met Ala Leu Gln His Gly Val Val Pro Arg Thr Leu His 
        355                 360                 365             


Val Asp Glu Pro Ser Arg His Val Asp Trp Ser Ala Gly Ala Val Asn 
    370                 375                 380                 


Leu Val Thr Glu Asn Leu Pro Trp Pro Ser Leu Asp Arg Pro Arg Arg 
385                 390                 395                 400 


Ala Gly Val Ser Ser Phe Gly Ile Ser Gly Thr Asn Ala His Val Ile 
                405                 410                 415     


Leu Glu Ser Val Pro Ala Gln Pro Pro Val Ser Ser Thr Gly Pro Ala 
            420                 425                 430         


Pro Leu Val Ile Ser Ala Lys Thr Gly Pro Ala Leu Thr Ala Phe Glu 
        435                 440                 445             


Ala Arg Leu Arg Thr Tyr Leu Ala Ala Ala Ser Glu Val Asp Leu Gly 
    450                 455                 460                 


Ala Val Ala Ala Thr Leu Ala Thr Thr Arg Ser Val Phe Glu His Arg 
465                 470                 475                 480 


Ala Val Leu Leu Gly Glu Glu Thr Ile Ala Gly Thr Ala Ala Val Asp 
                485                 490                 495     


Pro Arg Val Val Phe Val Phe Ser Gly Gln Gly Ser Gln Arg Ala Gly 
            500                 505                 510         


Met Gly Glu Gln Leu Ala Asp Ala Phe Pro Val Phe Ala Asp Ile His 
        515                 520                 525             


Arg Arg Val Trp Asp Leu Leu Asp Val Pro Asp Leu Asp Val Asn Gln 
    530                 535                 540                 


Thr Gly Tyr Ala Gln Pro Ala Leu Phe Ala Leu Gln Val Ala Leu Phe 
545                 550                 555                 560 


Gly Leu Leu Glu Ser Trp Gly Val Arg Pro Ala Ala Val Ile Gly His 
                565                 570                 575     


Ser Ile Gly Glu Leu Ala Ala Gly Tyr Val Ser Gly Leu Trp Ser Leu 
            580                 585                 590         


Glu Asp Ala Cys Thr Leu Val Ser Ala Arg Ala Arg Leu Met Gln Ala 
        595                 600                 605             


Leu Pro Pro Gly Gly Val Met Val Ala Val Pro Val Ser Glu Glu Gln 
    610                 615                 620                 


Ala Arg Gly Val Leu Val Glu Gly Val Glu Ile Ala Ala Val Asn Gly 
625                 630                 635                 640 


Pro Ser Ser Val Val Leu Ser Gly Asp Glu Ala Val Val Leu Gln Val 
                645                 650                 655     


Ala Ser Gly Leu Gly Lys Trp Thr Arg Leu Ser Thr Ser His Ala Phe 
            660                 665                 670         


His Ser Ala Arg Met Glu Pro Met Leu Glu Glu Phe Gln Ala Val Ala 
        675                 680                 685             


Glu Gln Leu Thr Tyr Arg Thr Pro Ala Ile Glu Met Ala Ala Gly Glu 
    690                 695                 700                 


Glu Val Thr Thr Pro Asp Tyr Trp Val Arg Gln Val Arg Asp Thr Val 
705                 710                 715                 720 


Arg Phe Gly Glu Gln Val Ala Ala Phe Ser Asp Ala Val Phe Val Glu 
                725                 730                 735     


Val Gly Pro Asp Arg Thr Leu Ala Arg Leu Ile Asp Gly Val Ala Met 
            740                 745                 750         


Leu His Gly Asp Asp Glu Pro Ser Ala Ala Leu Thr Gly Leu Ala Thr 
        755                 760                 765             


Leu Phe Val Gln Gly Val Pro Val Asp Trp Ser Ala Val Val Ser Gly 
    770                 775                 780                 


Thr Glu Ala Arg Val Leu Asp Leu Pro Thr Tyr Ala Phe Gln His Gln 
785                 790                 795                 800 


Arg Tyr Trp Leu Asp Arg Lys Ala Ala Arg Arg Ala Ala Ser Ala Gly 
                805                 810                 815     


Gly Asp Leu Leu Lys Met Val Arg Gly Asn Ala Ala Leu Ile Leu Gly 
            820                 825                 830         


His Ala Asp Pro Ser Ala Ile Ala Ala Thr Thr Ala Phe Arg Glu Leu 
        835                 840                 845             


Gly Val Asp Ser Leu Thr Ala Val Gln Leu Arg Asn Ser Leu Ala Lys 
    850                 855                 860                 


Ala Thr Gly Leu Arg Leu Pro Ala Thr Leu Val Phe Asp Tyr Pro Thr 
865                 870                 875                 880 


Pro Ala Val Leu Ala Gly Arg Leu 
                885             


<210>  113
<211>  880
<212>  PRT
<213>  Catellatospora sp.

<400>  113

Glu Pro Leu Ala Ile Val Gly Met Ala Cys Arg Leu Pro Gly Gly Val 
1               5                   10                  15      


Ser Ser Pro Glu Asp Leu Trp Arg Leu Val Glu Ser Gly Thr Asp Ala 
            20                  25                  30          


Ile Ser Asp Phe Pro Pro Asp Arg Gly Trp Asp Val Glu Asn Leu Phe 
        35                  40                  45              


Asp Pro Asp Pro Asp Ala Pro Gly Lys Thr Tyr Ser Ile His Gly Gly 
    50                  55                  60                  


Phe Leu Asp Thr Ala Ala Glu Phe Asp Ala Ala Phe Phe Gly Ile Ser 
65                  70                  75                  80  


Pro Arg Glu Ala Leu Ala Met Asp Pro Gln Gln Arg Leu Val Leu Glu 
                85                  90                  95      


Ala Ser Trp Glu Ala Phe Glu Arg Ala Gly Ile Glu Pro Gly Ser Val 
            100                 105                 110         


Gln Gly Ser Asp Thr Gly Val Phe Met Gly Ala Tyr Ser Ala Gly Tyr 
        115                 120                 125             


Gly Ala Gly Ala Asp Leu Asp Gly Phe Gly Ala Thr Ala Gly Ala Gly 
    130                 135                 140                 


Ser Val Leu Ser Gly Arg Ile Ser Tyr Phe Phe Gly Leu Glu Gly Pro 
145                 150                 155                 160 


Ala Met Thr Val Asp Thr Ala Cys Ser Ser Ser Leu Val Ala Leu His 
                165                 170                 175     


Gln Ala Gly Ser Ala Leu Arg Gln Gly Glu Cys Ser Leu Ala Leu Val 
            180                 185                 190         


Gly Gly Val Thr Val Met Ala Thr Pro Asp Leu Phe Val Glu Phe Ser 
        195                 200                 205             


Arg Gln Arg Gly Leu Ala Thr Asp Gly Arg Cys Lys Ala Phe Ala Asp 
    210                 215                 220                 


Thr Ala Asp Gly Thr Gly Trp Ala Glu Gly Val Gly Val Leu Leu Val 
225                 230                 235                 240 


Glu Arg Leu Ser Asp Ala Gln Ala Lys Gly His Arg Val Leu Ala Val 
                245                 250                 255     


Val Arg Gly Ser Ala Val Asn Gln Asp Gly Ala Ser Asn Gly Leu Thr 
            260                 265                 270         


Ala Pro Asn Gly Pro Ser Gln Gln Arg Val Ile Arg Gln Ala Leu Ala 
        275                 280                 285             


Asn Ala Gly Leu Ala Pro His Glu Val Asp Val Val Glu Ala His Gly 
    290                 295                 300                 


Thr Gly Thr Thr Leu Gly Asp Pro Ile Glu Ala Gln Ala Val Leu Ala 
305                 310                 315                 320 


Thr Tyr Gly Gln Asp Arg Glu Gln Pro Leu Leu Leu Gly Ser Leu Lys 
                325                 330                 335     


Ser Asn Val Gly His Thr Gln Ala Ala Ala Gly Val Ser Gly Val Ile 
            340                 345                 350         


Lys Met Val Met Ala Leu Gln Gln Gly Val Val Pro Gln Thr Leu His 
        355                 360                 365             


Val Asp Glu Pro Ser Gln His Val Asp Trp Ser Ala Gly Ala Val Asn 
    370                 375                 380                 


Leu Val Thr Gln Asn Gln Pro Trp Pro Asp Ile Asp Arg Pro Arg Arg 
385                 390                 395                 400 


Ala Ala Val Ser Ala Phe Gly Val Ser Gly Thr Asn Ala His Val Ile 
                405                 410                 415     


Leu Glu Ser Val Pro Ala Ser Pro Pro Val Pro Ser Thr Gly Pro Ala 
            420                 425                 430         


Pro Leu Val Ile Ser Ala Lys Thr Val Pro Ala Leu Thr Ala Phe Glu 
        435                 440                 445             


Ala Arg Leu Arg Thr Tyr Leu Ala Ala Val Pro Glu Val Asp Leu Gly 
    450                 455                 460                 


Ala Val Ala Ala Thr Leu Ala Thr Thr Arg Ala Thr Phe Glu His Arg 
465                 470                 475                 480 


Ala Val Leu Leu Gly Glu Glu Thr Ile Ala Gly Thr Ala Ala Val Asp 
                485                 490                 495     


Pro Arg Val Val Phe Val Phe Ser Gly Gln Gly Ser Gln Arg Ala Gly 
            500                 505                 510         


Met Gly Glu Gln Leu Ala Ala Ala Phe Pro Val Phe Ala Asp Ile His 
        515                 520                 525             


His Arg Val Trp Glu Leu Leu Asp Ile Pro Asp Leu Asp Val Asp Gln 
    530                 535                 540                 


Thr Gly Tyr Ala Gln Pro Ala Leu Phe Ala Leu Gln Val Ala Leu Phe 
545                 550                 555                 560 


Gly Leu Leu Glu Ser Trp Gly Val Arg Pro Ala Ala Val Ile Gly His 
                565                 570                 575     


Ser Val Gly Glu Leu Ala Ala Gly Tyr Val Ser Gly Leu Trp Ser Leu 
            580                 585                 590         


Glu Asp Ala Cys Thr Leu Val Ser Ala Arg Ala Arg Leu Met Gln Ala 
        595                 600                 605             


Leu Pro Pro Gly Gly Val Met Val Ala Val Pro Val Ser Glu Glu Gln 
    610                 615                 620                 


Ala Arg Ala Val Leu Val Glu Gly Val Glu Ile Ala Ala Val Asn Gly 
625                 630                 635                 640 


Pro Ser Ser Val Val Leu Ser Gly Asp Glu Ala Val Val Leu Gln Val 
                645                 650                 655     


Ala Ser Gly Leu Gly Lys Trp Thr Arg Leu Ser Thr Ser His Ala Phe 
            660                 665                 670         


His Ser Ala Arg Val Glu Pro Met Leu Glu Glu Phe Arg Val Ile Ala 
        675                 680                 685             


Gly Gln Leu Thr Tyr Arg Thr Pro Val Ile Glu Met Ala Ala Gly Glu 
    690                 695                 700                 


Gln Val Thr Ser Pro Asp Tyr Trp Val Arg Gln Val Arg Asp Thr Val 
705                 710                 715                 720 


Arg Phe Gly Glu Gln Val Ala Ala Phe Ser Asp Ala Val Phe Val Glu 
                725                 730                 735     


Ile Gly Pro Asp Arg Thr Leu Ala Arg Leu Ile Asp Gly Val Ala Leu 
            740                 745                 750         


Leu His Gly Asp Asp Glu Thr Glu Ala Ala Met Ala Gly Leu Ala Arg 
        755                 760                 765             


Leu Phe Val Gln Gly Val Pro Val Asp Trp Ser Ala Val Leu Gly Gly 
    770                 775                 780                 


Thr Glu Ala Arg Val Leu Asp Leu Pro Thr Tyr Ala Phe Gln His Gln 
785                 790                 795                 800 


Arg Tyr Trp Ala Ala Leu Thr Pro Glu Ala Leu Leu Lys Val Val Arg 
                805                 810                 815     


Asp Ser Ala Ala Met Val Leu Gly His Ala Asp Pro Ser Ala Ile Ser 
            820                 825                 830         


Gly Thr Ala Ala Phe Arg Asp Leu Gly Leu Asp Ser Leu Thr Ala Val 
        835                 840                 845             


Glu Leu Arg Asn Ser Leu Ala Lys Ala Thr Gly Leu Arg Leu Pro Ala 
    850                 855                 860                 


Thr Leu Val Phe Asp Tyr Pro Thr Pro Ser Val Leu Ala Gly Arg Leu 
865                 870                 875                 880 


<210>  114
<211>  886
<212>  PRT
<213>  Catellatospora sp.

<400>  114

Glu Pro Leu Ala Ile Val Gly Met Ala Cys Arg Leu Pro Gly Gly Val 
1               5                   10                  15      


Ser Ser Pro Glu Asp Leu Trp Arg Leu Val Glu Ser Gly Thr Asp Ala 
            20                  25                  30          


Ile Ser Asp Phe Pro Pro Asp Arg Gly Trp Asp Thr Ala Ser Leu Phe 
        35                  40                  45              


Asp Pro Asp Pro Asp Ala Ala Gly Lys Thr Tyr Ser Val Gln Gly Gly 
    50                  55                  60                  


Phe Leu Asp Ala Val Ala Glu Phe Asp Ala Gly Phe Phe Gly Ile Ser 
65                  70                  75                  80  


Pro Arg Glu Ala Leu Ala Met Asp Pro Gln Gln Arg Leu Val Leu Glu 
                85                  90                  95      


Ala Ser Trp Glu Ala Phe Glu Arg Ala Gly Ile Glu Pro Gly Ser Val 
            100                 105                 110         


Arg Gly Thr Asp Thr Gly Val Phe Met Gly Ala Phe Ser Ala Gly Tyr 
        115                 120                 125             


Gly Ala His Leu Glu Gly Phe Gly Ala Thr Ala Gly Ala Val Ser Val 
    130                 135                 140                 


Leu Ser Gly Arg Val Ser Tyr Leu Phe Gly Leu Glu Gly Pro Ala Met 
145                 150                 155                 160 


Thr Val Asp Thr Ala Cys Ser Ser Ser Leu Val Ala Leu His Gln Ala 
                165                 170                 175     


Ala Tyr Ser Leu Arg Gln Gly Glu Cys Ser Leu Ala Leu Val Gly Gly 
            180                 185                 190         


Val Thr Val Met Ala Thr Pro Gln Ile Phe Val Asp Phe Ser Arg Gln 
        195                 200                 205             


Arg Gly Leu Ala Ala Asp Gly Arg Cys Lys Ala Phe Ala Asp Asp Ala 
    210                 215                 220                 


Asp Gly Thr Gly Trp Ala Glu Gly Val Gly Val Leu Val Val Glu Arg 
225                 230                 235                 240 


Leu Ser Asp Ala Gln Ala Lys Gly His Arg Val Leu Ala Val Val Arg 
                245                 250                 255     


Ser Ser Ala Val Asn Gln Asp Gly Ala Ser Asn Gly Leu Thr Ala Pro 
            260                 265                 270         


Asn Gly Pro Ser Gln Gln Arg Val Ile Arg Gln Ala Leu Ala Asn Ala 
        275                 280                 285             


Gly Leu Thr Ser Ala Asp Val Asp Val Val Glu Ala His Gly Thr Gly 
    290                 295                 300                 


Thr Thr Leu Gly Asp Pro Ile Glu Ala Gln Ala Val Leu Ala Thr Tyr 
305                 310                 315                 320 


Gly Gln Asp Arg Glu Gln Pro Leu Leu Leu Gly Ser Leu Lys Ser Asn 
                325                 330                 335     


Leu Gly His Thr Gln Ala Ala Ala Gly Val Ser Gly Val Ile Lys Met 
            340                 345                 350         


Val Met Ala Leu Gln His Gly Ile Val Pro Arg Thr Leu His Val Asp 
        355                 360                 365             


Gln Pro Ser Gln His Val Asp Trp Ser Ala Gly Ala Val Glu Leu Val 
    370                 375                 380                 


Thr Glu Asn Gln Pro Trp Pro Ser Leu Asp Arg Pro Arg Arg Ala Gly 
385                 390                 395                 400 


Val Ser Ser Phe Gly Ile Ser Gly Thr Asn Ala His Val Ile Leu Glu 
                405                 410                 415     


Ser Val Pro Ala Ser Pro Pro Val Pro Ser Thr Gly Pro Ala Pro Leu 
            420                 425                 430         


Val Ile Ser Ala Lys Thr Gly Pro Ala Leu Thr Ala Phe Glu Ala Arg 
        435                 440                 445             


Leu Arg Thr Tyr Leu Ala Ala Thr Pro Asp Ala Asp Leu Pro Thr Ile 
    450                 455                 460                 


Ala Ser Thr Leu Ala Thr Thr Arg Ser Val Phe Glu His Arg Ala Val 
465                 470                 475                 480 


Leu Leu Gly Glu Glu Thr Ile Ala Gly Thr Ala Ala Val Asp Pro Arg 
                485                 490                 495     


Val Val Phe Val Phe Ser Gly Gln Gly Ser Gln Arg Ala Gly Met Gly 
            500                 505                 510         


Glu Gln Leu Ala Asp Ala Phe Pro Val Phe Ala Asp Ile His Arg Arg 
        515                 520                 525             


Val Trp Asp Leu Leu Asp Val Pro Asp Leu Asp Val Asn Gln Thr Gly 
    530                 535                 540                 


Tyr Ala Gln Pro Ala Leu Phe Ala Leu Gln Val Ala Leu Phe Gly Leu 
545                 550                 555                 560 


Leu Glu Ser Trp Gly Val Arg Pro Ala Ala Val Ile Gly His Ser Ile 
                565                 570                 575     


Gly Glu Leu Ala Ala Gly Tyr Val Ser Gly Leu Trp Ser Leu Glu Asp 
            580                 585                 590         


Ala Cys Thr Leu Val Ser Ala Arg Ala Arg Leu Met Gln Ala Leu Pro 
        595                 600                 605             


Pro Gly Gly Val Met Val Ala Val Pro Val Ser Glu Glu Gln Ala Arg 
    610                 615                 620                 


Gly Val Leu Val Glu Gly Val Glu Ile Ala Ala Val Asn Gly Pro Ser 
625                 630                 635                 640 


Ser Val Val Leu Ser Gly Asp Glu Ala Val Val Leu Gln Val Ala Ser 
                645                 650                 655     


Gly Leu Gly Lys Trp Thr Arg Leu Ser Thr Ser His Ala Phe His Ser 
            660                 665                 670         


Ala Arg Met Glu Pro Met Leu Glu Glu Phe Gln Ala Val Ala Glu Gln 
        675                 680                 685             


Leu Thr Tyr Arg Thr Pro Ala Ile Glu Met Ala Ala Gly Glu Glu Val 
    690                 695                 700                 


Thr Thr Pro Asp Tyr Trp Val Arg Gln Val Arg Asp Thr Val Arg Phe 
705                 710                 715                 720 


Gly Glu Gln Val Ala Ala Phe Ser Asp Ala Val Phe Val Glu Val Gly 
                725                 730                 735     


Pro Asp Arg Thr Leu Ala Arg Leu Ile Asp Gly Val Ala Met Leu His 
            740                 745                 750         


Gly Asp Asp Glu Pro Ser Ala Ala Gly Thr Ala Leu Ala Arg Leu His 
        755                 760                 765             


Val Gln Gly Val Pro Val Asp Trp Ser Ala Val Leu Gly Gly Thr Gly 
    770                 775                 780                 


Ala Arg Val Leu Asp Leu Pro Thr Tyr Ala Phe Gln Arg Gln Arg Tyr 
785                 790                 795                 800 


Trp Ala Gly Trp Leu Ala Gly Leu Ala Ala Glu Glu Arg Asp Lys Ala 
                805                 810                 815     


Leu Val Thr Val Val Arg Asp Ser Val Ala Ala Val Leu Gly Tyr Ala 
            820                 825                 830         


Asp Ser Arg Lys Ile Ala Leu Ser Ala Ser Phe Lys Glu Leu Gly Val 
        835                 840                 845             


Asp Ser Leu Thr Ala Val Glu Leu Arg Asn Asn Leu Ala Lys Thr Thr 
    850                 855                 860                 


Gly Leu Arg Leu Pro Ala Thr Leu Val Phe Asp His Pro Thr Leu Ala 
865                 870                 875                 880 


Ala Met Ala Ala Arg Leu 
                885     


<210>  115
<211>  902
<212>  PRT
<213>  Catellatospora sp.

<400>  115

Glu Pro Leu Ala Ile Val Gly Val Ala Cys Arg Leu Pro Gly Gly Val 
1               5                   10                  15      


Ser Ser Pro Glu Ala Leu Trp Arg Leu Val Glu Ser Gly Thr Asp Ala 
            20                  25                  30          


Ile Ser Gly Phe Pro Ala Asp Arg Gly Trp Asp Val Asp Asn Leu Phe 
        35                  40                  45              


Asp Pro Asp Pro Glu Ala Ser Gly Lys Thr Tyr Cys Val Gln Gly Gly 
    50                  55                  60                  


Phe Leu Asp Thr Val Ala Asp Phe Asp Ala Ser Phe Phe Gly Ile Ser 
65                  70                  75                  80  


Pro Arg Glu Ala Leu Ala Met Asp Pro Gln Gln Arg Leu Ile Leu Glu 
                85                  90                  95      


Val Cys Trp Glu Ala Phe Glu Arg Ala Gly Ile Glu Pro Gly Ser Val 
            100                 105                 110         


Arg Gly Ser Asp Thr Gly Val Phe Met Gly Ala Phe Gly Ser Gly Tyr 
        115                 120                 125             


Gly Ser Asp Leu Glu Gly Phe Ser Ala Thr Ala Gly Ala Gly Ser Val 
    130                 135                 140                 


Leu Ser Gly Arg Ile Ser Tyr Phe Phe Gly Leu Glu Gly Pro Ala Met 
145                 150                 155                 160 


Thr Val Asp Thr Ala Cys Ser Ser Ser Leu Val Ala Leu His Gln Ala 
                165                 170                 175     


Gly Tyr Ala Leu Arg Gln Gly Glu Cys Ser Leu Ala Leu Val Gly Gly 
            180                 185                 190         


Ala Thr Val Met Ala Thr Pro Gln Thr Phe Ile Glu Phe Ser Arg Gln 
        195                 200                 205             


Arg Gly Leu Ala Ala Asp Gly Arg Cys Lys Ser Phe Gly Asp Asn Ala 
    210                 215                 220                 


Asp Gly Thr Gly Trp Ser Glu Gly Val Gly Ala Leu Leu Val Glu Arg 
225                 230                 235                 240 


Leu Ser Asp Ala Gln Ala Lys Gly His Arg Val Leu Ala Val Val Arg 
                245                 250                 255     


Gly Ser Ala Val Asn Gln Asp Gly Ala Ser Asn Gly Leu Thr Ala Pro 
            260                 265                 270         


Asn Gly Pro Ser Gln Gln Arg Val Ile Arg Gln Ala Leu Ala Asn Ala 
        275                 280                 285             


Gly Leu Ala Pro His Glu Val Asp Val Val Glu Ala His Gly Thr Gly 
    290                 295                 300                 


Thr Arg Leu Gly Asp Pro Ile Glu Ala Gln Ala Val Leu Ala Thr Tyr 
305                 310                 315                 320 


Gly Gln Asp Arg Glu Arg Pro Leu Leu Leu Gly Ser Leu Lys Ser Asn 
                325                 330                 335     


Val Gly His Thr Gln Ala Ala Ala Gly Val Ser Gly Val Ile Lys Met 
            340                 345                 350         


Val Met Ala Leu Gln His Ser Val Val Pro Gln Thr Leu His Val Asp 
        355                 360                 365             


Ala Pro Ser Arg Gln Val Asp Trp Ser Ala Gly Ala Val Glu Leu Val 
    370                 375                 380                 


Thr Gln Asn Gln Pro Trp Pro Glu Thr Gly Arg Ala Arg Arg Ala Ala 
385                 390                 395                 400 


Val Ser Ala Phe Gly Val Ser Gly Thr Asn Ala His Val Ile Leu Glu 
                405                 410                 415     


Ser Ala Pro Ala Gln Pro Pro Ala Pro Ser Thr Pro Val Thr Gly Pro 
            420                 425                 430         


Val Pro Leu Val Ile Ser Ala Lys Thr Ala Ser Ala Leu Gly Gln Ala 
        435                 440                 445             


Glu Ala Arg Leu Arg Thr Tyr Leu Ala Asp Lys Pro Asp Ala Asp Leu 
    450                 455                 460                 


Ala Ala Ile Ala Ala Thr Leu Ala Thr Thr Arg Ser Thr Phe Glu His 
465                 470                 475                 480 


Arg Ala Val Leu Leu Gly Asp Glu Thr Ile Arg Gly Val Ala Val Pro 
                485                 490                 495     


Asp Pro Arg Val Val Phe Val Phe Pro Gly Gln Gly Trp Gln Trp Leu 
            500                 505                 510         


Gly Met Gly Ser Ala Leu Arg Glu Ser Ser Val Val Phe Ala Glu Arg 
        515                 520                 525             


Met Ala Glu Cys Ala Ala Ala Leu Ser Asp Tyr Val Asp Trp Asp Leu 
    530                 535                 540                 


Phe Ser Val Leu Asp Asp Leu Ala Val Val Asp Arg Val Asp Val Val 
545                 550                 555                 560 


Gln Pro Ala Cys Trp Ala Val Met Val Ser Leu Ala Ala Thr Trp Gln 
                565                 570                 575     


Ala Ala Gly Val Arg Pro Asp Ala Val Ile Gly His Ser Gln Gly Glu 
            580                 585                 590         


Ile Ala Ala Ala Cys Val Ala Gly Ala Ile Ser Leu Arg Asp Ala Ala 
        595                 600                 605             


Gln Ile Val Ala Leu Arg Ser Gln Leu Ile Ala Gly Leu Ala Gly Gln 
    610                 615                 620                 


Gly Ala Met Ala Ser Ile Ala Leu Pro Ala Asp Gln Ile Thr Leu Thr 
625                 630                 635                 640 


Asp Gly Val Trp Ile Ala Ala Arg Asn Gly Leu Ala Ala Thr Val Ile 
                645                 650                 655     


Ala Gly Asp Pro Ala Ala Val Asp Gly Val Leu Ala Ala His Gln Asp 
            660                 665                 670         


Ala Arg Val Arg Arg Ile Thr Val Asp Tyr Ala Ser His Thr Pro His 
        675                 680                 685             


Val Glu Gln Ile Arg Thr Glu Leu Leu Asp Leu Thr Thr Asp Ile Ser 
    690                 695                 700                 


Ser Arg Thr Pro Ala Ile Pro Trp Leu Ser Thr Val Asp Ser Thr Trp 
705                 710                 715                 720 


Ile Glu Gly Pro Leu Asp Thr Asp Tyr Trp Tyr Arg Asn Leu Arg Glu 
                725                 730                 735     


Pro Val Gly Phe Asp Thr Ala Val Asn Leu Leu Pro Asp Ser Val Phe 
            740                 745                 750         


Ile Glu Val Ser Ala Ser Pro Val Leu Leu Pro Ala Met Gly Asp Ala 
        755                 760                 765             


Ala Thr Val Ala Thr Leu Arg Arg Asp Asp Gly Ser Gln Thr Arg Leu 
    770                 775                 780                 


Leu Thr Ala Leu Ala Glu Ala Tyr Val Gln Gly Val Ala Ile Asp Trp 
785                 790                 795                 800 


Thr Ile Gly Ala Thr Thr Ala Arg Val Leu Asp Leu Pro Thr Tyr Ala 
                805                 810                 815     


Phe Gln His Gln Arg Phe Trp Val Ala Asn Ala Leu Thr Pro Glu Ala 
            820                 825                 830         


Leu Leu Lys Val Val Arg Asp Ser Ala Ala Thr Val Leu Gly His Ala 
        835                 840                 845             


Asp Pro Gly Thr Ile Pro Glu Thr Ala Ala Phe Lys Asp Leu Gly Val 
    850                 855                 860                 


Asp Ser Leu Thr Ala Val Glu Leu Arg Asn Ser Leu Ala Lys Ala Thr 
865                 870                 875                 880 


Gly Leu Arg Leu Pro Ala Thr Leu Val Phe Asp Tyr Pro Thr Pro Ser 
                885                 890                 895     


Val Leu Ala Gly Arg Leu 
            900         


<210>  116
<211>  886
<212>  PRT
<213>  Catellatospora sp.

<400>  116

Glu Pro Leu Ala Ile Val Gly Met Ala Cys Arg Leu Pro Gly Gly Val 
1               5                   10                  15      


Ser Ser Pro Glu Asp Leu Trp Arg Leu Val Glu Ser Gly Thr Asp Ala 
            20                  25                  30          


Ile Ser Asp Phe Pro Ala Asp Arg Gly Trp Asp Ile Glu Asn Leu Phe 
        35                  40                  45              


Asp Pro Asp Pro Asp Ala Pro Gly Lys Thr Tyr Ser Val Gln Gly Gly 
    50                  55                  60                  


Phe Leu Asp Thr Ala Ala Glu Phe Asp Ala Gly Phe Phe Gly Ile Ser 
65                  70                  75                  80  


Pro Arg Glu Ala Leu Ala Met Asp Pro Gln Gln Arg Leu Val Leu Glu 
                85                  90                  95      


Ala Ser Trp Glu Val Phe Glu Arg Ala Gly Ile Glu Pro Gly Ser Val 
            100                 105                 110         


Arg Gly Ser Asp Thr Gly Val Phe Met Gly Ala Tyr Pro Gly Tyr Tyr 
        115                 120                 125             


Gly Ile Gly Ala Asp Leu Asp Gly Phe Gly Ala Thr Ala Gly Ala Gly 
    130                 135                 140                 


Ser Val Leu Ser Gly Arg Val Ser Tyr Phe Phe Gly Leu Glu Gly Pro 
145                 150                 155                 160 


Ala Met Thr Ile Asp Thr Ala Cys Ser Ser Ser Leu Val Ala Leu His 
                165                 170                 175     


Gln Ala Gly Ser Ala Leu Arg Gln Gly Glu Cys Ser Leu Ala Leu Val 
            180                 185                 190         


Gly Gly Val Thr Val Met Ala Thr Pro Gln Thr Tyr Val Glu Phe Ser 
        195                 200                 205             


Arg Gln Arg Gly Leu Ala Ser Asp Gly Arg Ser Lys Ala Phe Ala Asp 
    210                 215                 220                 


Ala Ala Asp Gly Ala Gly Phe Ser Glu Gly Val Gly Val Leu Leu Val 
225                 230                 235                 240 


Glu Arg Leu Ser Asp Ala Arg Arg His Gly His Arg Val Leu Ala Val 
                245                 250                 255     


Val Arg Ser Ser Ala Val Asn Gln Asp Gly Ala Ser Asn Gly Leu Thr 
            260                 265                 270         


Ala Pro Asn Gly Pro Ser Gln Gln Arg Val Ile Gly Ser Ala Leu Ala 
        275                 280                 285             


Asn Ala Gly Leu Ala Pro His Asp Val Asp Val Val Glu Ala His Gly 
    290                 295                 300                 


Thr Gly Thr Ala Leu Gly Asp Pro Ile Glu Ala Gln Ala Val Leu Ala 
305                 310                 315                 320 


Thr Tyr Gly Gln Asp Arg Glu Gln Pro Leu Leu Leu Gly Ser Val Lys 
                325                 330                 335     


Ser Asn Leu Gly His Thr Gln Ala Ala Ala Gly Val Ser Gly Val Ile 
            340                 345                 350         


Lys Met Val Met Ala Leu Gln His Gly Ile Val Pro Arg Thr Leu His 
        355                 360                 365             


Val Asp Glu Pro Ser Arg His Val Asp Trp Ser Ala Gly Ala Val Glu 
    370                 375                 380                 


Leu Val Thr Glu Asn Gln Pro Trp Pro Glu His Asp Arg Pro Arg Arg 
385                 390                 395                 400 


Ala Gly Val Ser Ser Phe Gly Ile Ser Gly Thr Asn Ala His Val Ile 
                405                 410                 415     


Leu Glu Ser Val Pro Ala Gln Pro Pro Val Ser Ser Thr Gly Pro Ala 
            420                 425                 430         


Pro Leu Val Ile Ser Ala Lys Thr Ala Ser Ala Leu Gly Gln Ala Glu 
        435                 440                 445             


Ala Arg Leu Arg Thr Tyr Leu Thr Val Asp Ala Asp Leu Pro Ala Ile 
    450                 455                 460                 


Ala Ala Thr Leu Ala Thr Thr Arg Ala Val Phe Glu His Arg Ala Val 
465                 470                 475                 480 


Leu Leu Gly Asp Thr Thr Ile Thr Gly Val Ala Ala Asp Pro Arg Val 
                485                 490                 495     


Val Phe Val Phe Ser Gly Gln Gly Ser Gln Arg Ala Gly Met Gly Glu 
            500                 505                 510         


Gln Leu Ala Ala Ala Phe Pro Val Phe Ala Asp Thr His Arg Arg Val 
        515                 520                 525             


Trp Asp Leu Leu Asp Val Pro Asp Leu Asp Val Asp Gln Thr Gly Tyr 
    530                 535                 540                 


Ala Gln Pro Ala Leu Phe Ala Leu Gln Val Ala Leu Phe Gly Leu Leu 
545                 550                 555                 560 


Glu Ser Trp Gly Val Arg Pro Glu Ala Val Ile Gly His Ser Val Gly 
                565                 570                 575     


Glu Leu Ala Ala Gly Tyr Val Ser Gly Leu Trp Ser Leu Glu Asp Ala 
            580                 585                 590         


Cys Ala Leu Val Ser Ala Arg Ala Arg Leu Met Gln Ala Leu Pro Pro 
        595                 600                 605             


Gly Gly Val Met Val Ala Val Ala Val Ser Glu Glu Gln Ala Arg Thr 
    610                 615                 620                 


Ala Leu Val Glu Gly Val Glu Ile Ala Ala Val Asn Gly Pro Gly Ser 
625                 630                 635                 640 


Val Val Leu Ser Gly Asp Glu Ala Val Val Leu Gln Val Ala Ser Gly 
                645                 650                 655     


Leu Gly Lys Trp Thr Arg Leu Ala Thr Ser His Ala Phe His Ser Ala 
            660                 665                 670         


Arg Met Glu Pro Met Leu Glu Glu Phe Arg Ala Val Ala Glu Gln Leu 
        675                 680                 685             


Thr Tyr Arg Thr Pro Ala Ile Glu Met Ala Ala Gly Glu Gln Val Thr 
    690                 695                 700                 


Thr Pro Asp Tyr Trp Val Arg Gln Val Arg Asp Thr Val Arg Phe Gly 
705                 710                 715                 720 


Glu Gln Val Ala Ala Phe Gly Asp Ala Val Phe Val Glu Ile Gly Pro 
                725                 730                 735     


Asp Arg Thr Leu Ala Arg Leu Ile Asp Gly Val Ala Met Leu His Gly 
            740                 745                 750         


Asp Asp Glu Thr Glu Ala Ala Met Ala Gly Leu Ala Lys Leu Phe Val 
        755                 760                 765             


Glu Gly Ile Pro Val Asp Trp Ser Ala Val Leu Gly Gly Asn Ala Ala 
    770                 775                 780                 


Arg Val Asp Leu Pro Thr Tyr Ala Phe Gln Arg Gln Arg Tyr Trp Ala 
785                 790                 795                 800 


Ala Ser Leu Leu Ala Gly Leu Thr Pro Glu Glu Arg Gly Asn Ala Leu 
                805                 810                 815     


Leu Lys Val Val Arg Asp Asn Ala Ala Val Ile Leu Gly His Ala Gly 
            820                 825                 830         


Ala Ala Ala Ile Pro Ala Thr Ala Ala Phe Arg Asp Leu Gly Val Asp 
        835                 840                 845             


Ser Leu Thr Ala Val Glu Leu Arg Asn Ser Leu Ala Thr Ser Thr Gly 
    850                 855                 860                 


Leu Arg Leu Pro Ala Thr Met Val Phe Asp Tyr Pro Thr Pro Ala Ala 
865                 870                 875                 880 


Met Ala Ala Arg Leu Asp 
                885     


<210>  117
<211>  914
<212>  PRT
<213>  Catellatospora sp.

<400>  117

Glu Pro Leu Ala Ile Val Gly Met Ala Cys Arg Leu Pro Gly Gly Val 
1               5                   10                  15      


Phe Ser Pro Glu Asp Leu Trp His Leu Val Glu Ser Gly Thr Asp Ala 
            20                  25                  30          


Ile Ser Gly Phe Pro Ala Asp Arg Gly Trp Asp Val Glu Lys Leu Phe 
        35                  40                  45              


Asp Pro Asp Pro Asp Ala Pro Gly Lys Thr Tyr Cys Val Gln Gly Gly 
    50                  55                  60                  


Phe Leu Glu Ala Thr Ala Ala Phe Asp Ala Ala Phe Phe Gly Ile Ser 
65                  70                  75                  80  


Pro Arg Glu Ala Leu Ala Met Asp Pro Gln Gln Arg Leu Met Leu Glu 
                85                  90                  95      


Val Ser Trp Glu Ala Phe Glu Arg Ala Gly Ile Glu Pro Gly Ser Val 
            100                 105                 110         


Arg Gly Ser Asp Thr Gly Val Phe Leu Gly Ala Tyr Pro Gly Gly Tyr 
        115                 120                 125             


Gly Ala Gly Ala Gly Thr Asp Leu Gly Gly Phe Gly Ala Thr Gly Gly 
    130                 135                 140                 


Ala Gly Ser Val Leu Ser Gly Arg Val Ser Tyr Phe Phe Gly Leu Glu 
145                 150                 155                 160 


Gly Pro Ala Met Thr Val Asp Thr Ala Cys Ser Ser Ser Leu Val Ala 
                165                 170                 175     


Leu His Gln Ala Ala Tyr Ser Leu Arg Gln Arg Glu Cys Ser Leu Ala 
            180                 185                 190         


Leu Val Gly Gly Val Thr Val Met Gly Thr Pro His Met Phe Val Asp 
        195                 200                 205             


Phe Ser Arg Gln Arg Gly Leu Ser Val Asp Gly Arg Cys Lys Ala Phe 
    210                 215                 220                 


Ala Asp Ala Ala Asp Gly Thr Ser Trp Ser Glu Gly Val Gly Val Leu 
225                 230                 235                 240 


Leu Val Glu Arg Leu Ser Asp Ala Gln Ala Lys Gly His Arg Val Leu 
                245                 250                 255     


Ala Val Val Arg Gly Ser Ala Val Asn Gln Asp Gly Ala Ser Asn Gly 
            260                 265                 270         


Leu Thr Ala Pro Asn Gly Pro Ser Gln Gln Arg Val Ile Arg Gln Ala 
        275                 280                 285             


Leu Ala Asn Ala Gly Leu Ala Pro His Glu Val Asp Val Val Glu Ala 
    290                 295                 300                 


His Gly Thr Gly Thr Thr Leu Gly Asp Pro Ile Glu Ala Gln Ala Val 
305                 310                 315                 320 


Leu Ala Thr Tyr Gly Gln Asp Arg Glu Gln Pro Leu Leu Leu Gly Ser 
                325                 330                 335     


Leu Lys Ser Asn Val Gly His Thr Gln Ala Ala Ala Gly Val Ser Gly 
            340                 345                 350         


Val Ile Lys Met Val Met Ala Leu Gln Arg Gly Val Val Pro Gln Thr 
        355                 360                 365             


Leu His Val Asp Gln Pro Ser Arg His Val Asp Trp Ser Ala Gly Ala 
    370                 375                 380                 


Val Asp Leu Thr Thr Glu Asn Arg Pro Trp Pro Asp Thr Asp Arg Pro 
385                 390                 395                 400 


Arg Arg Ala Gly Val Ser Ser Phe Gly Val Ser Gly Thr Asn Ala His 
                405                 410                 415     


Val Ile Leu Glu Ser Ala Pro Ala Gln Pro Pro Thr Pro Ser Thr Pro 
            420                 425                 430         


Val Thr Gly Pro Val Pro Leu Val Ile Ser Ala Lys Thr Ala Ser Ala 
        435                 440                 445             


Leu Gly Gln Ala Glu Ala Arg Leu Arg Asp Tyr Leu Thr Ala Asp Ala 
    450                 455                 460                 


Asp Leu Thr Ala Ile Ala Ala Thr Leu Ala Ile Thr Arg Ser Thr Phe 
465                 470                 475                 480 


Glu His Arg Ala Val Leu Leu Gly Asp Asp Thr Ile Thr Gly Val Ala 
                485                 490                 495     


Thr Pro Asp Pro Arg Val Val Phe Val Phe Pro Gly Gln Gly Trp Gln 
            500                 505                 510         


Trp Leu Gly Met Gly Ser Ala Leu Arg Glu Ser Ser Val Val Phe Ala 
        515                 520                 525             


Glu Arg Met Ala Glu Cys Ala Ala Ala Leu Asp Glu Phe Val Asp Trp 
    530                 535                 540                 


Asp Leu Phe Ser Val Leu Asp Asp Pro Ala Val Val Asp Arg Val Asp 
545                 550                 555                 560 


Val Val Gln Pro Ala Cys Trp Ala Val Met Val Ser Leu Ala Ala Thr 
                565                 570                 575     


Trp Gln Ala Ala Gly Val Arg Pro Asp Ala Val Ile Gly His Ser Gln 
            580                 585                 590         


Gly Glu Ile Ala Ala Ala Cys Val Ala Gly Ala Ile Ser Leu Arg Asp 
        595                 600                 605             


Gly Ala Lys Ile Val Ala Leu Arg Ser Gln Leu Ile Ala Gly Leu Ala 
    610                 615                 620                 


Gly Gln Gly Ala Met Ala Ser Ile Ala Leu Pro Ala Asp Gln Ile Thr 
625                 630                 635                 640 


Leu Thr Asp Gly Val Trp Ile Ala Ala Arg Asn Gly Pro Ala Ala Thr 
                645                 650                 655     


Val Ile Ala Gly Thr Pro Ser Ala Val Asp Ser Val Leu Ala Ala His 
            660                 665                 670         


Gln Asp Ala Arg Val Arg Arg Ile Thr Val Asp Tyr Ala Ser His Thr 
        675                 680                 685             


Pro His Val Glu Gln Ile Arg Thr Glu Leu Leu Gly Ile Leu Ala Asp 
    690                 695                 700                 


Ile Asp Ser Gln Thr Pro Leu Ile Pro Trp Leu Ser Thr Met Glu Gly 
705                 710                 715                 720 


Thr Trp Val Glu Gly Pro Leu His Ser Asp Tyr Trp Tyr Arg Asn Leu 
                725                 730                 735     


Arg Glu Pro Val Gly Phe Asp Thr Ala Val Ser Leu Leu Pro Asp Ser 
            740                 745                 750         


Val Phe Ile Glu Val Ser Ala Ser Pro Val Leu Leu Pro Ala Met Gly 
        755                 760                 765             


Asp Ala Leu Thr Val Ala Thr Leu Arg Arg Asp Glu Gly Gly Gln Asn 
    770                 775                 780                 


Arg Met Phe Thr Ala Leu Ala Glu Ala Tyr Val Gln Gly Val Ala Val 
785                 790                 795                 800 


Asp Trp Ala Ala Val Ile Gly Ala Thr Thr Ala Arg Val Leu Asp Leu 
                805                 810                 815     


Pro Thr Tyr Ala Phe Gln His Glu Asp Tyr Trp Leu Asp Ser Thr Arg 
            820                 825                 830         


Leu Met Gly Leu Ala Ala Glu Glu Arg Asp Lys Ala Leu Val Thr Val 
        835                 840                 845             


Val Arg Glu Ser Ala Ala Val Val Leu Gly His Ala Asp Ala Arg Ala 
    850                 855                 860                 


Ile Pro Val Thr Ala Ala Phe Arg Glu Leu Gly Val Asp Ser Leu Thr 
865                 870                 875                 880 


Ala Val Gln Leu Arg Asn Ser Leu Ala Lys Ala Thr Gly Leu Arg Leu 
                885                 890                 895     


Pro Thr Thr Leu Ala Phe Asp Tyr Pro Thr Pro Ala Val Leu Ala Ala 
            900                 905                 910         


Arg Leu 
        


<210>  118
<211>  908
<212>  PRT
<213>  Catellatospora sp.

<400>  118

Glu Pro Leu Ala Ile Val Gly Met Ala Cys Arg Leu Pro Gly Gly Val 
1               5                   10                  15      


Leu Ser Pro Glu Asp Leu Trp Arg Leu Val Glu Ser Gly Thr Asp Ala 
            20                  25                  30          


Ile Ser Gly Leu Pro Thr Asp Arg Gly Trp Asp Ile Asp Asn Leu Tyr 
        35                  40                  45              


Asp Pro Glu Pro Gly Ala Pro Gly Lys Ser Tyr Cys Val Gln Gly Gly 
    50                  55                  60                  


Phe Leu Asp Thr Val Ala Asp Phe Asp Pro Ala Phe Phe Gly Ile Ser 
65                  70                  75                  80  


Pro Arg Glu Ala Leu Ala Met Asp Pro Gln Gln Arg Leu Val Leu Glu 
                85                  90                  95      


Val Ser Trp Glu Ala Phe Glu Arg Ala Gly Ile Glu Pro Gly Ser Val 
            100                 105                 110         


Arg Gly Ser Asp Thr Gly Val Phe Met Gly Ala Phe Gly Asn Gly Tyr 
        115                 120                 125             


Gly Ile Asp Thr Asp Gly Gly Gly Phe Gly Ala Thr Ala Gly Thr Gly 
    130                 135                 140                 


Ser Val Leu Ser Gly Arg Val Ser Tyr Phe Leu Gly Leu Glu Gly Pro 
145                 150                 155                 160 


Ala Met Thr Val Asp Thr Gly Cys Ser Ser Ala Leu Val Ala Leu His 
                165                 170                 175     


Gln Ala Arg Tyr Ala Leu Arg Gln Gly Asp Cys Ser Leu Ala Leu Val 
            180                 185                 190         


Gly Gly Val Thr Val Met Ala Ser Pro Tyr Thr Phe Val Glu Phe Ser 
        195                 200                 205             


Arg Gln Arg Gly Met Ala Ala Asn Gly Arg Cys Lys Ala Phe Ala Asp 
    210                 215                 220                 


Ala Ala Asp Gly Thr Gly Trp Ala Glu Gly Val Gly Val Leu Leu Val 
225                 230                 235                 240 


Glu Arg Leu Ser Asp Ala Glu Ala Lys Gly His Arg Val Leu Ala Val 
                245                 250                 255     


Val Arg Gly Ser Ala Leu Asn Gln Asp Gly Ala Ser Asn Gly Leu Thr 
            260                 265                 270         


Ala Pro Asn Gly Pro Ser Gln Gln Arg Val Ile Gln Ala Ala Leu Ala 
        275                 280                 285             


Asn Ala Gly Leu Val Ser Ala Asp Val Asp Val Val Glu Ala His Gly 
    290                 295                 300                 


Thr Gly Thr Thr Leu Gly Asp Pro Ile Glu Ala Gln Ala Val Leu Ala 
305                 310                 315                 320 


Thr Tyr Gly Gln Asp Arg Glu His Pro Leu Leu Leu Gly Ser Leu Lys 
                325                 330                 335     


Ser Asn Ile Gly His Thr Gln Ala Ala Ala Gly Val Ser Gly Leu Ile 
            340                 345                 350         


Lys Met Val Met Ala Leu Gln His Gly Val Val Pro Gln Thr Leu His 
        355                 360                 365             


Val Asp Glu Pro Ser Arg His Val Asp Trp Ser Ala Gly Ala Val Glu 
    370                 375                 380                 


Leu Val Thr Glu Asn Arg Pro Trp Pro Ser Val Asp Arg Pro Arg Arg 
385                 390                 395                 400 


Ala Gly Val Ser Ala Phe Gly Ile Ser Gly Thr Asn Ala His Val Ile 
                405                 410                 415     


Leu Glu Ser Ala Pro Pro Ser Pro Ala Pro Ser Thr Pro Val Thr Gly 
            420                 425                 430         


Leu Val Pro Leu Val Ile Ser Ala Lys Thr Ala Pro Ala Leu Gly Gln 
        435                 440                 445             


Ala Glu Ala Arg Leu Arg Asp Tyr Leu Thr Ala Asp Val Asp Leu Thr 
    450                 455                 460                 


Ala Ile Ala Ala Thr Leu Val Thr Thr Arg Ser Thr Phe Glu His Arg 
465                 470                 475                 480 


Ala Val Leu Leu Gly Asp Asp Thr Val Thr Gly Val Ala Val Pro Asp 
                485                 490                 495     


Pro Arg Val Val Phe Val Phe Pro Gly Gln Gly Trp Gln Trp Leu Gly 
            500                 505                 510         


Met Gly Ser Ala Leu Arg Glu Ser Ser Val Val Phe Ala Glu Arg Met 
        515                 520                 525             


Ala Glu Cys Ala Ser Ala Leu Ser Asp Tyr Val Asp Trp Asp Leu Phe 
    530                 535                 540                 


Thr Val Leu Asp Asp Pro Ala Val Val Asp Arg Val Asp Val Val Gln 
545                 550                 555                 560 


Pro Ala Cys Trp Ala Val Met Val Ser Leu Ala Ala Thr Trp Gln Ala 
                565                 570                 575     


Ala Gly Val Arg Pro Asp Ala Val Ile Gly His Ser Gln Gly Glu Ile 
            580                 585                 590         


Ala Ala Ala Cys Val Ala Gly Ala Ile Ser Leu Arg Asp Ala Ala Gln 
        595                 600                 605             


Ile Val Ala Leu Arg Ser Gln Leu Ile Ala Gly Leu Ala Gly His Gly 
    610                 615                 620                 


Ala Met Ala Ser Ile Ala Leu Pro Ala Asp Gln Ile Thr Leu Thr Asp 
625                 630                 635                 640 


Gly Val Trp Ile Ala Ala Arg Asn Gly Pro Thr Ala Thr Val Ile Ala 
                645                 650                 655     


Gly Asn Pro Gln Ala Val Asp Ser Val Leu Ala Ala His Gln Asp Ala 
            660                 665                 670         


Arg Val Arg Arg Ile Thr Val Asp Tyr Ala Ser His Thr Pro His Val 
        675                 680                 685             


Glu Gln Ile Arg Thr Glu Leu Leu Asp Leu Thr Thr Asp Val Gly Ser 
    690                 695                 700                 


Arg Thr Pro Ala Ile Pro Trp Leu Ser Thr Val Asp Gly Glu Trp Val 
705                 710                 715                 720 


Glu Gly Pro Leu Asp Thr Asp Tyr Trp Tyr Arg Asn Leu Arg Glu Pro 
                725                 730                 735     


Val Gly Phe Asp Thr Ala Val Gly Met Leu Pro Asp Ser Val Phe Ile 
            740                 745                 750         


Glu Val Ser Ala Ser Pro Val Leu Leu Pro Ala Met Gly Asp Ala Ala 
        755                 760                 765             


Thr Val Ala Thr Leu Arg Arg Asp Asp Gly Gly Gln Thr Arg Leu Leu 
    770                 775                 780                 


Thr Ala Leu Ala Glu Ala Tyr Val Gln Gly Val Ala Val Asp Trp Ala 
785                 790                 795                 800 


Val Gly Ala Thr Thr Ala Arg Val Leu Asp Leu Pro Thr Tyr Ala Phe 
                805                 810                 815     


Gln His Gln Arg Tyr Trp Val Ala Asp Arg Leu His Asp Arg Pro Gly 
            820                 825                 830         


Val Glu Gln His Arg Leu Met Arg Glu Leu Val Leu Arg His Ala Ala 
        835                 840                 845             


Thr Val Leu Gly His Asp Ser Pro Asp Ala Ile Ala Ala Asp His Pro 
    850                 855                 860                 


Phe Lys Asp Leu Gly Leu Asp Ser Leu Thr Ala Val Glu Leu Arg Asn 
865                 870                 875                 880 


His Leu Val Ala Glu Thr Gly Leu Arg Leu Ser Ala Thr Thr Ala Phe 
                885                 890                 895     


Asp His Pro Thr Ala Asp Asp Leu Ala Arg His Leu 
            900                 905             


<210>  119
<211>  955
<212>  PRT
<213>  Catellatospora sp.

<400>  119

Glu Pro Ile Ala Ile Val Ser Met Ala Cys Arg Ala Pro Gly Gly Val 
1               5                   10                  15      


Ser Ser Pro Glu Gly Leu Trp Arg Leu Val Glu Ser Gly Thr Asp Ala 
            20                  25                  30          


Thr Ser Gly Phe Pro Thr Asp Arg Gly Trp Asp Val Glu Asn Leu Phe 
        35                  40                  45              


Asp Pro Asp Pro Asp Ala Ala Gly Lys Thr Tyr Ser Met Arg Gly Gly 
    50                  55                  60                  


Phe Leu Glu Thr Ala Ala Asp Phe Asp Ala Pro Phe Phe Gly Ile Ser 
65                  70                  75                  80  


Pro Arg Glu Ala Leu Gly Met Asp Pro Gln Gln Arg Leu Leu Leu Glu 
                85                  90                  95      


Thr Ala Trp Glu Ala Ile Glu Arg Ala Gln Ile Asp Pro Lys Ser Leu 
            100                 105                 110         


Arg Gly Gln Asp Val Gly Val Tyr Val Gly Gly Ala Ala Gln Gly Tyr 
        115                 120                 125             


Gly Ile Gly Ala Thr Asp Gln Gln Gln Glu Asn Leu Ile Thr Gly Ser 
    130                 135                 140                 


Ser Ile Ser Leu Leu Ser Gly Arg Val Ser Tyr Ala Leu Gly Leu Glu 
145                 150                 155                 160 


Gly Pro Gly Val Thr Val Asp Thr Ala Cys Ser Ser Ser Leu Val Ala 
                165                 170                 175     


Leu His Leu Ala Gly Gln Ala Leu Arg Gln Arg Glu Cys Ser Leu Ala 
            180                 185                 190         


Leu Val Ser Gly Val Ser Val Met Ala Thr Pro Asp Val Phe Val Glu 
        195                 200                 205             


Phe Ser Arg Gln Arg Gly Leu Ala Ala Asp Gly Arg Cys Lys Ser Phe 
    210                 215                 220                 


Ala Ala Ser Ala Asp Gly Thr Thr Trp Ser Glu Gly Val Gly Val Leu 
225                 230                 235                 240 


Val Leu Gln Arg Leu Ser Glu Ala Val Arg Gln Gly His Arg Val Leu 
                245                 250                 255     


Ala Val Val Arg Gly Ser Ala Val Asn Ser Asp Gly Ala Ser Asn Gly 
            260                 265                 270         


Leu Thr Ala Pro Asn Gly Val Ser Gln Arg Arg Val Ile Arg Gln Ala 
        275                 280                 285             


Leu Ala Ser Ala Gly Leu Ala Ala Ser Glu Val Asp Val Val Glu Ala 
    290                 295                 300                 


His Gly Thr Gly Thr Lys Leu Gly Asp Pro Ile Glu Ala Glu Ala Ile 
305                 310                 315                 320 


Leu Ala Thr Tyr Gly Gln Asp Arg Ala Ala Pro Ala Trp Leu Gly Ser 
                325                 330                 335     


Leu Lys Ser Asn Ile Gly His Thr Met Ala Ala Ser Gly Val Leu Gly 
            340                 345                 350         


Val Ile Lys Met Val Glu Ala Met Arg His Gly Leu Leu Pro Arg Thr 
        355                 360                 365             


Leu His Val Asp Glu Pro Ser Ser His Val Asp Trp Glu Arg Gly Asp 
    370                 375                 380                 


Val Ala Leu Leu Thr Glu Asn Gln Pro Trp Pro Asp Ser Thr Arg Pro 
385                 390                 395                 400 


Arg Arg Ala Gly Val Ser Ser Phe Gly Leu Ser Gly Thr Asn Ala His 
                405                 410                 415     


Val Val Leu Glu Glu Tyr Pro Ala Pro Ala Ala Ala Asp Pro Pro Val 
            420                 425                 430         


Thr Pro Ala Gly Gly Gly Pro Leu Pro Trp Val Leu Ser Ala Gln Ser 
        435                 440                 445             


Pro Asn Ala Leu Arg Glu Gln Ala Ala Arg Leu Tyr Ala Ala Leu Ala 
    450                 455                 460                 


Glu Asp Pro Asp Trp Arg Pro Leu Asp Ile Gly Tyr Ser Leu Ala Thr 
465                 470                 475                 480 


Thr Arg Ala Gly Phe Pro His Arg Ala Val Ala Val Gly Ser Asp Arg 
                485                 490                 495     


Glu Glu Phe Gln Arg Ala Leu Ser Lys Leu Ala Asp Gly Thr Gly Trp 
            500                 505                 510         


Pro Gly Leu Ile Thr Ala Thr Ala Ala Lys Asp Arg Arg Met Ala Phe 
        515                 520                 525             


Leu Phe Asp Gly Gln Gly Thr Gln Arg Leu Gly Met Gly Lys Gly Leu 
    530                 535                 540                 


His Arg Arg Phe Pro Val Phe Ala Arg Ala Trp Asp Ala Val Ser Ala 
545                 550                 555                 560 


Ala Phe Ala Lys His Leu Asp His Ser Leu Thr Asp Ile Tyr Leu Gly 
                565                 570                 575     


Pro Ser Ser Pro Ala Ser Ala Glu Leu Ala Asp Asp Thr Leu Tyr Ala 
            580                 585                 590         


Gln Ala Gly Ile Phe Thr Met Glu Val Ala Leu Val Glu Leu Leu Glu 
        595                 600                 605             


Asp Trp Gly Val Arg Pro Asp Phe Val Ala Gly His Ser Ile Gly Glu 
    610                 615                 620                 


Ala Ala Ala Ala Tyr Thr Ala Gly Met Phe Ser Leu Glu Asp Val Thr 
625                 630                 635                 640 


Ala Leu Ile Val Ala Arg Gly Arg Ala Leu Arg Leu Thr Pro Pro Gly 
                645                 650                 655     


Glu Met Val Ala Leu Arg Gly Gly Glu Ala Asp Val Arg Glu Leu Leu 
            660                 665                 670         


Gln Arg Thr Gly Ala Ala Leu Asp Leu Ala Ala Val Asn Ser Pro Glu 
        675                 680                 685             


Ala Val Val Val Ser Gly Ala Pro Asp Ala Val Ala Glu Phe Arg Ala 
    690                 695                 700                 


Ala Trp Thr Ala Ser Gly Arg Arg Ala Arg Asp Leu Thr Val Arg His 
705                 710                 715                 720 


Ala Phe His Ser Arg His Val Glu Ser Val Leu Asp Glu Phe Arg Ala 
                725                 730                 735     


Thr Leu Ala Ala Leu Thr Phe Arg Ala Pro Ala Leu Pro Val Val Ser 
            740                 745                 750         


Thr Met Thr Gly Arg Leu Ala Asp Pro Ala Glu Met Gly Thr Pro Glu 
        755                 760                 765             


Tyr Trp Leu Arg Gln Val Arg Gln Thr Val Arg Phe Glu Glu Ala Val 
    770                 775                 780                 


Arg Glu Leu Ser Gly Gln Gly Val Gly Thr Phe Val Glu Ile Gly Pro 
785                 790                 795                 800 


Ser Gly Ala Leu Ala Thr Ala Gly Leu Glu Cys Leu Gly Gly Asp Ala 
                805                 810                 815     


Thr Phe His Ala Val Gln Arg Pro Arg Ala Pro Glu Asp Val Cys Leu 
            820                 825                 830         


Met Thr Ala Val Ala Glu Leu His Ala Gly Gly Thr Ala Val Asp Trp 
        835                 840                 845             


Thr Lys Ile Leu Ala Gly Gly Arg Pro Val Asp Leu Pro Val Tyr Pro 
    850                 855                 860                 


Phe Gln His Arg Pro Tyr Trp Ile Ala Pro Ala Pro Ser Tyr Pro Asp 
865                 870                 875                 880 


Glu Pro Arg Thr Met Arg Glu Leu Val Arg Leu Glu Val Ala Gly Ile 
                885                 890                 895     


Leu Gly Leu Ser Asp Pro Ser Val Ile Leu Asp Asp Ser Ser Phe Leu 
            900                 905                 910         


Glu Leu Gly Phe Asp Ser Leu Ser Ser Met Arg Leu Gly Asn Arg Leu 
        915                 920                 925             


Ala Thr Val Thr Gly Leu Asp Leu Pro Ser Thr Leu Leu Phe Glu Tyr 
    930                 935                 940                 


Ala Thr Pro Ala Ala Leu Ala Thr His Leu Asp 
945                 950                 955 


<210>  120
<211>  917
<212>  PRT
<213>  Actinoplanes sp.

<400>  120

Glu Pro Leu Ala Ile Val Gly Met Ala Cys Arg Leu Pro Gly Gly Val 
1               5                   10                  15      


Glu Ser Pro Asp Asp Leu Trp Arg Leu Val Ala Ser Gly Thr Asp Ala 
            20                  25                  30          


Ile Ser Gly Phe Pro Arg Asp Arg Gly Trp Asp Val Asp Asn Leu Tyr 
        35                  40                  45              


Asp Pro Asp Pro Asp Ala Pro Gly Lys Thr Tyr Thr Val Leu Gly Gly 
    50                  55                  60                  


Phe Leu Asp Ser Val Ala Gly Phe Asp Ala Ser Phe Phe Gly Ile Ser 
65                  70                  75                  80  


Pro Arg Glu Ala Leu Ala Met Asp Pro Gln Gln Arg Leu Val Leu Glu 
                85                  90                  95      


Val Ala Trp Glu Ala Phe Glu His Ala Gly Ile Ala Pro Arg Ser Val 
            100                 105                 110         


Arg Gly Thr Asp Thr Gly Val Phe Met Gly Ala Phe Ser Ser Gly Tyr 
        115                 120                 125             


Asp Ala Glu Leu Glu Glu Phe Gly Met Thr Gly Asp Ala Val Ser Val 
    130                 135                 140                 


Leu Ser Gly Arg Val Ser Tyr Phe Phe Gly Leu Glu Gly Pro Ala Met 
145                 150                 155                 160 


Thr Val Asp Thr Ala Cys Ser Ser Ser Leu Val Ala Leu His Gln Ala 
                165                 170                 175     


Ser Ser Ala Leu Arg Gln Gly Glu Cys Ser Leu Ala Leu Val Gly Gly 
            180                 185                 190         


Val Thr Val Leu Ala Thr Pro Lys Thr Phe Val Glu Phe Ser Arg Gln 
        195                 200                 205             


Arg Gly Leu Ala Gly Asp Gly Arg Ser Lys Ala Phe Ala Asp Ala Ala 
    210                 215                 220                 


Asp Gly Ala Gly Trp Ser Glu Gly Val Gly Val Leu Leu Val Glu Arg 
225                 230                 235                 240 


Leu Ser Asp Ala Arg Ala Lys Gly His His Val Leu Gly Val Val Arg 
                245                 250                 255     


Gly Ser Ala Val Asn Gln Asp Gly Ala Ser Asn Gly Leu Ser Ala Pro 
            260                 265                 270         


Asn Gly Pro Ser Gln Gln Arg Val Ile Arg Gln Ala Leu Ala Gly Ala 
        275                 280                 285             


Gly Leu Ser Pro His Glu Val Asp Val Val Glu Ala His Gly Thr Gly 
    290                 295                 300                 


Thr Lys Leu Gly Asp Pro Ile Glu Ala Gln Ala Val Ile Ala Thr Tyr 
305                 310                 315                 320 


Gly Gln Asp Arg Asp Gln Pro Ala Leu Leu Gly Ser Leu Lys Ser Asn 
                325                 330                 335     


Val Gly His Thr Gln Ala Ala Ala Gly Val Ala Gly Val Ile Lys Met 
            340                 345                 350         


Val Met Ala Leu Gln His Ala Thr Val Pro Ala Thr Leu His Val Asp 
        355                 360                 365             


Ala Pro Thr Arg His Val Asp Trp Thr Ala Gly Ala Val Glu Leu Val 
    370                 375                 380                 


Thr Glu Asn Arg Pro Trp Pro Glu Thr Gly Arg Ala Arg Arg Ala Ala 
385                 390                 395                 400 


Val Ser Ser Phe Gly Ile Ser Gly Thr Asn Ala His Val Ile Leu Glu 
                405                 410                 415     


Ser Ala Pro Ala Ala Ala Pro Glu Glu Thr Glu Pro Val Ala Pro Val 
            420                 425                 430         


Val Ala Ser Asp Arg Val Pro Leu Val Ile Ser Ala Lys Thr Pro Ala 
        435                 440                 445             


Ala Leu Thr Ser Thr Glu Asp Arg Leu Arg Ala Tyr Leu Ala Ala His 
    450                 455                 460                 


Pro Gly Thr Asp Pro Arg Ala Val Ala Ser Thr Leu Ala Thr Thr Arg 
465                 470                 475                 480 


Ser Val Phe Glu His Arg Ala Val Leu Leu Gly Glu Asn Thr Val Thr 
                485                 490                 495     


Gly Ser Val Ala Gly Ala Asp Pro Arg Val Val Phe Val Phe Pro Gly 
            500                 505                 510         


Gln Gly Trp Gln Arg Leu Gly Met Gly Arg Glu Leu Leu Ala Ala Ser 
        515                 520                 525             


Pro Val Phe Ala Gly Arg Met Ala Glu Cys Ala Thr Val Leu Arg Glu 
    530                 535                 540                 


Phe Val Asp Trp Asp Leu Phe Thr Met Leu Asp Asp Pro Ala Val Val 
545                 550                 555                 560 


Asp Arg Ile Glu Val Val Gln Pro Val Cys Trp Ala Ile Met Val Ser 
                565                 570                 575     


Leu Ala Ala Val Trp Gln Ala Ala Gly Val Arg Pro Asp Ala Val Ile 
            580                 585                 590         


Gly His Ser Gln Gly Glu Ile Ala Ala Ala Cys Val Ser Gly Ala Val 
        595                 600                 605             


Ser Leu Arg Asp Ala Ala Arg Ile Val Thr Phe Arg Ser Asp Met Ile 
    610                 615                 620                 


Ala Arg Met Thr Gly His Gly Val Met Ala Ser Val Ala Leu His Ala 
625                 630                 635                 640 


Asp Asp Ile Pro Leu Val Glu Gly Ala Trp Val Ala Ala Arg Asn Gly 
                645                 650                 655     


Pro Ala Ala Thr Val Val Ala Gly Thr Pro Glu Ala Val Asp Gln Val 
            660                 665                 670         


Leu Ala Ala Cys Glu Glu Arg Gly Ala Arg Val Arg Arg Ile Thr Ala 
        675                 680                 685             


Gly Val Ala Ser His Thr Pro Leu Ala Glu His Val Arg Gly Glu Leu 
    690                 695                 700                 


Leu Asp Ala Thr Gly Gly Leu Pro Ser Arg Val Pro Asp Ile Pro Trp 
705                 710                 715                 720 


Leu Ser Thr Val Asp Gly Thr Trp Val Glu Lys Pro Leu Asp Pro Ala 
                725                 730                 735     


Tyr Trp Phe Arg Asn Met Arg Glu Pro Val Gly Phe Ala Pro Ala Val 
            740                 745                 750         


Asp Leu Leu Arg Ala Gln Gly Asp His Val Phe Leu Glu Ile Ser Ala 
        755                 760                 765             


Ser Pro Val Leu Leu Pro Ser Met Asp Asp Ala Val Thr Val Ala Thr 
    770                 775                 780                 


Leu Arg Arg Asp Asp Gly Ser Ala Asp Arg Met Leu Ala Ala Leu Ala 
785                 790                 795                 800 


Glu Ala His Thr His Gly Val Val Val Asp Trp Pro Arg Val Leu Gly 
                805                 810                 815     


Thr Ala Gly Arg Val Arg Gly Leu Pro Thr Tyr Ala Phe Gln His Gln 
            820                 825                 830         


Arg Tyr Trp Ala Val Ser Arg Pro Ala Val Leu Thr Pro Asp Ala Leu 
        835                 840                 845             


Leu Lys Val Val Arg Asp Ser Ala Ala Thr Val Leu Gly Tyr Thr Asp 
    850                 855                 860                 


Ala Asp Ser Ile Thr Val Thr Thr Ala Phe Arg Asp Leu Gly Val Asp 
865                 870                 875                 880 


Ser Leu Ser Ala Val Glu Leu Arg Asn Asn Leu Ala Lys Ser Thr Gly 
                885                 890                 895     


Leu Arg Leu Pro Ala Thr Leu Val Phe Asp Tyr Pro Thr Pro Ala Asp 
            900                 905                 910         


Leu Ala Thr His Leu 
        915         


<210>  121
<211>  881
<212>  PRT
<213>  Actinoplanes sp.

<400>  121

Glu Pro Leu Ala Ile Ile Gly Met Ala Cys Arg Leu Pro Gly Gly Ile 
1               5                   10                  15      


Thr Ser Pro Glu Asp Leu Trp Arg Leu Val Ala Ser Gly Ser Asp Ala 
            20                  25                  30          


Ile Ser Asp Phe Pro Asp Asp Arg Gly Trp Asp Val Gly Asn Leu Tyr 
        35                  40                  45              


Asp Pro Asp Pro Asp Ala Pro Gly Arg Ser Thr Thr Val Arg Gly Gly 
    50                  55                  60                  


Phe Leu Asp Glu Val Ala Gly Phe Asp Ala Ser Phe Phe Gly Ile Ser 
65                  70                  75                  80  


Pro Arg Glu Ala Leu Ala Met Asp Pro Gln Gln Arg Leu Val Leu Glu 
                85                  90                  95      


Val Ser Trp Glu Ala Phe Glu Arg Ala Gly Ile Glu Pro Gly Thr Val 
            100                 105                 110         


Arg Gly Ser Asp Thr Gly Val Phe Met Gly Ala Tyr Pro Gly Gly Tyr 
        115                 120                 125             


Gly Val Gly Ala Asp Leu Gly Gly Phe Gly Thr Thr Ala Val Ser Gly 
    130                 135                 140                 


Ser Val Leu Ser Gly Arg Val Ser Tyr Phe Phe Gly Leu Glu Gly Pro 
145                 150                 155                 160 


Ala Met Thr Val Asp Thr Ala Cys Ser Ser Ser Leu Val Ala Leu His 
                165                 170                 175     


Gln Ala Gly His Ala Leu Arg Gln Gly Glu Cys Ser Leu Ala Leu Val 
            180                 185                 190         


Gly Gly Val Thr Val Met Pro Thr Pro Asn Ile Phe Val Glu Phe Ser 
        195                 200                 205             


Arg Gln Arg Gly Leu Ala Ala Asp Gly Arg Cys Lys Pro Phe Ala Asp 
    210                 215                 220                 


Ala Ala Asp Gly Thr Gly Phe Ser Glu Gly Ala Gly Val Leu Leu Val 
225                 230                 235                 240 


Glu Arg Leu Ser Asp Ala Gln Thr Asn Gly His His Ile Leu Ala Val 
                245                 250                 255     


Val Arg Ala Ser Ala Val Asn Gln Asp Gly Ala Ser Asn Gly Leu Thr 
            260                 265                 270         


Ala Pro Asn Gly Pro Ser Gln Gln Arg Val Ile Arg Ser Ala Leu Ala 
        275                 280                 285             


Asn Ala Gly Leu Thr Thr Ala Asp Val Asp Val Val Glu Ala His Gly 
    290                 295                 300                 


Thr Gly Thr Thr Leu Gly Asp Pro Ile Glu Ala Gln Ala Val Ile Ala 
305                 310                 315                 320 


Thr Tyr Gly Gln Asp Arg Ala Gln Pro Val Leu Leu Gly Ser Leu Lys 
                325                 330                 335     


Ser Asn Ile Gly His Thr Gln Ala Ala Ala Gly Val Ser Gly Val Ile 
            340                 345                 350         


Lys Met Val Met Ala Leu Arg Asn Gly Thr Val Pro Arg Thr Leu His 
        355                 360                 365             


Val Asp Glu Pro Ser Arg His Ile Asp Trp Thr Ala Gly Ala Val Glu 
    370                 375                 380                 


Leu Ala Thr Glu Asn Arg Pro Trp Pro Glu Thr Glu Arg Pro Arg Arg 
385                 390                 395                 400 


Ala Gly Val Ser Ser Phe Gly Ile Ser Gly Thr Asn Ala His Val Ile 
                405                 410                 415     


Leu Glu Ser Thr Pro Thr Gln Pro Val Glu Pro Ser Thr Pro Ala Ala 
            420                 425                 430         


His Pro Leu Pro Leu Pro Ile Ser Ala Lys Thr Pro Pro Ala Leu Ala 
        435                 440                 445             


Ala Leu Glu Ala Arg Leu Arg Ala Tyr Leu Thr Ser Glu Thr Asp Leu 
    450                 455                 460                 


Ala Ala Val Ala Ser Thr Leu Ala Ser Thr Arg Ala Val Phe Glu His 
465                 470                 475                 480 


Arg Ala Val Leu Leu Gly Asp Glu Thr Ile Val Gly Val Ala Ala Leu 
                485                 490                 495     


Asp Pro Arg Val Val Phe Val Phe Ser Gly Gln Gly Ser Gln Arg Ala 
            500                 505                 510         


Gly Met Gly Glu Gln Leu Ala Ala Val Phe Pro Val Phe Ala Gln Ile 
        515                 520                 525             


His Arg Glu Val Leu Asp Leu Leu Asp Ile Pro Asp Leu Asp Ile Asp 
    530                 535                 540                 


Gln Thr Gly His Ala Gln Pro Ala Leu Phe Ala Phe Gln Val Ala Leu 
545                 550                 555                 560 


Ala Gly Leu Leu Asp Ser Trp Gly Val Arg Pro Asp Ala Val Ile Gly 
                565                 570                 575     


His Ser Ile Gly Glu Leu Ala Ala Ala Tyr Ile Ala Gly Leu Trp Ser 
            580                 585                 590         


Leu Glu Asp Ala Cys Thr Leu Val Ser Ala Arg Ala Arg Leu Met Gln 
        595                 600                 605             


Ala Leu Pro Ser Gly Gly Ala Met Val Ala Val Gln Ala Thr Glu Glu 
    610                 615                 620                 


Gln Ala Arg Ala Val Leu Ile Asp Gly Val Glu Ile Ala Ala Val Asn 
625                 630                 635                 640 


Gly Pro Ser Ser Val Val Leu Ser Gly Asp Glu Thr Ala Val Leu Gln 
                645                 650                 655     


Val Ala Ala Glu Leu Gly Gly Lys Ser Ala Arg Leu Lys Thr Ser His 
            660                 665                 670         


Ala Phe His Ser Ala Arg Met Glu Pro Met Leu Asp Gln Phe Arg Gln 
        675                 680                 685             


Val Ala Glu Gln Leu Thr Tyr Arg Ser Pro Val Ile Glu Met Ala Ala 
    690                 695                 700                 


Gly Thr Thr Ser Asp Tyr Trp Val Arg Gln Val Arg Asp Thr Val Arg 
705                 710                 715                 720 


Phe Gly Asp Gln Val Arg Val His Gln Gly Ser Val Leu Val Glu Ile 
                725                 730                 735     


Gly Pro Asp Arg Thr Leu Ala Arg Leu Ile Asp Gly Ile Ala Thr Ser 
            740                 745                 750         


His Gly Asp Asp Glu Val Arg Ala Val Met Thr Ala Leu Ala Glu Leu 
        755                 760                 765             


His Val Arg Gly Val Ala Val Asp Trp Pro Gly Thr Thr Ser Ala Arg 
    770                 775                 780                 


Val Leu Asp Leu Pro Thr Tyr Ala Phe Gln His Glu Arg Tyr Trp Leu 
785                 790                 795                 800 


Ala Asn Thr Ala Ala Glu Leu Thr Ala Ala Asp Leu Leu Lys Ala Val 
                805                 810                 815     


Arg Asp Ser Ala Ala Val Val Leu Gly His Ala Asp Ala Asp Ser Ile 
            820                 825                 830         


Pro Ala Thr Thr Ala Phe Lys Asp Leu Gly Phe Asp Ser Leu Thr Ala 
        835                 840                 845             


Ile Glu Leu Arg Asn Arg Leu Ala Lys Asp Ile Gly Leu Arg Leu Pro 
    850                 855                 860                 


Ala Thr Met Ala Phe Asp Tyr Pro Thr Pro Ala Ala Leu Ala Ala Arg 
865                 870                 875                 880 


Leu 
    


<210>  122
<211>  887
<212>  PRT
<213>  Actinoplanes sp.

<400>  122

Glu Pro Leu Ala Ile Val Gly Met Ala Cys Arg Leu Pro Gly Gly Val 
1               5                   10                  15      


Thr Ser Pro Glu Asp Leu Trp Arg Leu Val Ala Ser Gly Thr Asp Ala 
            20                  25                  30          


Ile Thr Glu Phe Pro Thr Asp Arg Gly Trp Asp Val Gly Asn Leu Tyr 
        35                  40                  45              


Asp Pro Asp Pro Asp Ala Pro Gly Lys Ser Thr Thr Val His Gly Gly 
    50                  55                  60                  


Phe Leu Glu Gly Val Ala Gly Phe Asp Ala Ser Phe Phe Gly Ile Ser 
65                  70                  75                  80  


Pro Arg Glu Ala Leu Ala Met Asp Pro Gln Gln Arg Leu Val Leu Glu 
                85                  90                  95      


Val Ser Trp Glu Ala Phe Glu Arg Ala Gly Ile Glu Pro Gly Ala Val 
            100                 105                 110         


Arg Gly Ser Asp Thr Gly Val Phe Met Gly Ala Tyr Pro Gly Gly Tyr 
        115                 120                 125             


Gly Val Gly Ala Asp Leu Gly Gly Phe Gly Thr Thr Ala Gly Ala Gly 
    130                 135                 140                 


Ser Val Leu Ser Gly Arg Val Ser Tyr Phe Phe Gly Leu Glu Gly Pro 
145                 150                 155                 160 


Ala Met Thr Val Asp Thr Ala Cys Ser Ser Ser Leu Val Ala Leu His 
                165                 170                 175     


Gln Ala Gly His Ala Leu Arg Gln Gly Glu Cys Ser Leu Ala Leu Val 
            180                 185                 190         


Gly Gly Val Thr Val Met Pro Thr Pro Asn Ile Phe Val Glu Phe Ser 
        195                 200                 205             


Arg Gln Arg Gly Leu Ser Ala Asp Gly Arg Cys Lys Pro Phe Ala Asp 
    210                 215                 220                 


Ala Ala Asp Gly Thr Gly Trp Ser Glu Gly Val Gly Val Leu Val Val 
225                 230                 235                 240 


Glu Arg Leu Ser Asp Ala Arg Ala Asn Gly His Arg Ile Leu Ala Val 
                245                 250                 255     


Val Arg Gly Ser Ala Val Asn Gln Asp Gly Ala Ser Asn Gly Leu Thr 
            260                 265                 270         


Ala Pro Asn Gly Pro Ser Gln Gln Arg Val Ile Arg Gln Ala Leu Ala 
        275                 280                 285             


Asn Ala Gly Leu Thr Thr Ala Asp Val Asp Val Ile Glu Ala His Gly 
    290                 295                 300                 


Thr Gly Thr Thr Leu Gly Asp Pro Ile Glu Ala Gln Ala Val Ile Ala 
305                 310                 315                 320 


Thr Tyr Gly Gln Asp Arg Thr Gln Pro Val Leu Leu Gly Ser Leu Lys 
                325                 330                 335     


Ser Asn Ile Gly His Thr Gln Ala Ala Ala Gly Val Ser Gly Val Ile 
            340                 345                 350         


Lys Met Val Met Ala Leu Gln His Asp Thr Val Pro Ala Ser Leu His 
        355                 360                 365             


Val Asp Glu Pro Ser Arg His Val Asp Trp Thr Ala Gly Ala Val Glu 
    370                 375                 380                 


Leu Ala Thr Glu Ser Arg Pro Trp Pro Lys Thr Gly Arg Ala His Arg 
385                 390                 395                 400 


Ala Gly Val Ser Ser Phe Gly Val Ser Gly Thr Asn Ala His Val Ile 
                405                 410                 415     


Leu Glu Ser Ala Pro Thr Gln Pro Glu Glu Pro Ser Thr Pro Ala Pro 
            420                 425                 430         


His Pro Leu Pro Leu Pro Val Ser Ala Lys Thr Ser Ala Ala Leu Thr 
        435                 440                 445             


Asp Leu Glu Asp Arg Ile Arg Ala Tyr Leu Thr Pro Glu Thr Asp Leu 
    450                 455                 460                 


Ala Ala Val Ala Ser Thr Leu Ala Ser Thr Arg Ala Met Phe Glu His 
465                 470                 475                 480 


Arg Ala Val Leu Leu Gly Asp Glu Thr Ile Thr Gly Val Ala Ala Pro 
                485                 490                 495     


Asp Pro Arg Leu Val Phe Val Phe Ser Gly Gln Gly Ser Gln Arg Ala 
            500                 505                 510         


Gly Met Gly Glu Gln Leu Ala Ala Val Phe Pro Val Phe Ala Gln Ile 
        515                 520                 525             


His Arg Glu Val Leu Asp Leu Leu Asp Val Pro Asp Leu Asp Ile Asp 
    530                 535                 540                 


Gln Thr Gly His Ala Gln Pro Ala Leu Phe Ala Phe Gln Val Ala Leu 
545                 550                 555                 560 


Ala Gly Leu Leu Asp Ser Trp Gly Val Arg Pro Asp Ala Val Ile Gly 
                565                 570                 575     


His Ser Ile Gly Glu Leu Ala Ala Ala Tyr Val Ala Gly Leu Trp Ser 
            580                 585                 590         


Leu Gln Asp Ala Cys Ala Leu Val Ser Ala Arg Ala Arg Leu Met Gln 
        595                 600                 605             


Ala Leu Pro Pro Gly Gly Ala Met Val Ala Val Ala Val Pro Glu Glu 
    610                 615                 620                 


Gln Ala Arg Ala Val Leu Ile Asp Gly Val Glu Ile Ala Ala Val Asn 
625                 630                 635                 640 


Gly Pro Ser Ser Val Val Leu Ser Gly Asp Glu Thr Ala Val Leu Gln 
                645                 650                 655     


Val Ala Ala Glu Leu Gly Gly Lys Ser Thr Arg Leu Arg Thr Ser His 
            660                 665                 670         


Ala Phe His Ser Ala Arg Met Glu Pro Met Leu Asp Gln Phe Arg Gln 
        675                 680                 685             


Val Ala Glu Gln Leu Thr Tyr Arg Ser Pro Val Ile Glu Met Ala Ala 
    690                 695                 700                 


Gly Thr Thr Pro Asp Tyr Trp Val Arg Gln Val Arg Asp Thr Val Arg 
705                 710                 715                 720 


Phe Gly Asp Gln Val Arg Val His Gln Gly Ser Val Leu Val Glu Ile 
                725                 730                 735     


Gly Pro Asp Arg Thr Leu Ala Arg Leu Ile Asp Gly Ile Ala Thr Ser 
            740                 745                 750         


His Gly Asp Asp Glu Val Arg Ala Ala Met Thr Ala Leu Ala Glu Leu 
        755                 760                 765             


His Val Arg Gly Val Ala Val Asp Trp Pro Gly Thr Thr Ser Ala Arg 
    770                 775                 780                 


Val Leu Asp Leu Pro Thr Tyr Ala Phe Gln His Arg Arg Tyr Trp Val 
785                 790                 795                 800 


Ala Pro Ala Arg Arg Ala Ala Gly Arg Pro Ala Asp Leu Thr Pro Glu 
                805                 810                 815     


Gly Leu Leu Thr Thr Val Arg Asp Ser Ala Ala Val Val Leu Gly His 
            820                 825                 830         


Ala Asp Ala Ser Ala Ile Pro Ala Thr Ala Ala Phe Gln Ala Leu Gly 
        835                 840                 845             


Val Asp Ser Leu Ile Ala Val Glu Leu Arg Asn Asn Leu Ala Lys Asn 
    850                 855                 860                 


Thr Gly Leu Arg Leu Pro Ala Thr Leu Ile Phe Asp Tyr Pro Thr Pro 
865                 870                 875                 880 


Val Asp Leu Ala Thr His Leu 
                885         


<210>  123
<211>  886
<212>  PRT
<213>  Actinoplanes sp.

<400>  123

Glu Pro Leu Ala Ile Ile Gly Met Ser Cys Arg Leu Pro Gly Gly Val 
1               5                   10                  15      


Thr Ser Pro Glu Asp Leu Trp Arg Leu Val Ala Ser Gly Thr Asp Ala 
            20                  25                  30          


Ile Thr Gly Phe Pro Ala Asp Arg Gly Trp Asp Leu Glu Asn Leu Tyr 
        35                  40                  45              


Asp Pro Asp Pro Asp Ala Pro Gly Arg Thr Thr Thr Val Gln Gly Gly 
    50                  55                  60                  


Phe Leu Asp Asp Val Ala Gly Phe Asp Ala Ser Phe Phe Gly Ile Ser 
65                  70                  75                  80  


Pro Arg Glu Ala Val Ala Met Asp Pro Gln Gln Arg Leu Ala Leu Glu 
                85                  90                  95      


Ala Ser Trp Glu Ala Phe Glu Arg Ala Gly Ile Glu Pro Gly Ser Val 
            100                 105                 110         


Arg Gly Ser Asp Thr Gly Val Phe Met Gly Ala Tyr Pro Gly Gly Tyr 
        115                 120                 125             


Gly Ile Gly Ala Asp Leu Gly Ala Phe Met Leu Thr Gly Arg Ala Gly 
    130                 135                 140                 


Ser Val Leu Ser Gly Arg Leu Ser Tyr Phe Phe Gly Leu Glu Gly Pro 
145                 150                 155                 160 


Ala Met Thr Val Asp Thr Ala Cys Ser Ser Ser Leu Val Ala Leu His 
                165                 170                 175     


Gln Ala Ser Tyr Ala Leu Arg Gln Gly Glu Cys Ser Met Ala Leu Val 
            180                 185                 190         


Gly Gly Val Thr Val Met Pro Thr Pro Val Met Phe Val Glu Phe Ser 
        195                 200                 205             


Arg Gln Arg Asn Leu Ala Asp Asp Gly Arg Cys Lys Ala Phe Ala Asp 
    210                 215                 220                 


Gly Ala Asp Gly Thr Gly Trp Ser Glu Gly Val Gly Val Leu Leu Val 
225                 230                 235                 240 


Glu Arg Leu Ser Asp Ala Leu Ala Lys Gly His Arg Ile Met Ala Val 
                245                 250                 255     


Val Arg Gly Ser Ala Val Asn Gln Asp Gly Ala Ser Asn Gly Leu Thr 
            260                 265                 270         


Ala Pro Asn Gly Pro Ser Gln Gln Arg Val Ile Gln Ser Ala Leu Asp 
        275                 280                 285             


Ser Ala Gly Leu Thr Thr Ala Asp Val Asp Val Ile Glu Ala His Gly 
    290                 295                 300                 


Thr Gly Thr Thr Leu Gly Asp Pro Ile Glu Ala Gln Ala Val Ile Ala 
305                 310                 315                 320 


Thr Tyr Gly Gln Asp Arg Ala Gln Pro Val Leu Leu Gly Ser Leu Lys 
                325                 330                 335     


Ser Asn Ile Gly His Thr Gln Ala Ala Ala Gly Val Ser Gly Val Ile 
            340                 345                 350         


Lys Met Val Met Ala Leu Gln Asn Gly Val Val Pro Arg Thr Leu His 
        355                 360                 365             


Val Asp Glu Pro Ser Arg His Val Asp Trp Thr Ala Gly Ala Val Glu 
    370                 375                 380                 


Leu Ala Thr Glu Asn Arg Pro Trp Pro Glu Val Gly Arg Ala Arg Arg 
385                 390                 395                 400 


Ala Ala Val Ser Ser Phe Gly Phe Ser Gly Thr Asn Ala His Val Ile 
                405                 410                 415     


Leu Glu Ser Ala Pro Ala Gln Pro Ala Thr Pro Ser Ala Pro Val Ala 
            420                 425                 430         


His Leu Leu Pro Leu Pro Ile Ser Ala Lys Thr Pro Pro Ala Leu Ala 
        435                 440                 445             


Asp Leu Glu Ala Arg Leu Arg Ala Tyr Leu Thr Pro Glu Ala Asp Leu 
    450                 455                 460                 


Pro Ala Val Ala Ser Thr Leu Ala Ser Thr Arg Ala Val Phe Glu His 
465                 470                 475                 480 


Arg Ala Val Leu Leu Gly Asp Glu Thr Ile Val Gly Ile Ala Ala Leu 
                485                 490                 495     


Asp Pro Arg Val Val Phe Val Phe Ser Gly Gln Gly Ala Gln Arg Ala 
            500                 505                 510         


Gly Met Gly Glu Gln Leu Ala Ala Val Phe Pro Val Phe Ala Gln Ile 
        515                 520                 525             


His Arg Glu Val Leu Asp Leu Leu Asp Ile Pro Asp Leu Asp Ile Asp 
    530                 535                 540                 


Gln Thr Gly His Ala Gln Pro Ala Leu Phe Ala Phe Gln Val Ala Leu 
545                 550                 555                 560 


Ala Gly Leu Leu Glu Ser Trp Gly Val Arg Pro Asp Ala Val Ile Gly 
                565                 570                 575     


His Ser Ile Gly Glu Leu Ala Ala Ala Tyr Ile Ala Gly Leu Trp Ser 
            580                 585                 590         


Leu Glu Asp Ala Cys Ala Leu Val Ser Ala Arg Ala Arg Leu Met Gln 
        595                 600                 605             


Ala Leu Pro Ser Gly Gly Ala Met Val Ala Val Gln Ala Thr Glu Asp 
    610                 615                 620                 


Gln Ala Arg Ala Val Leu Ile Asp Gly Val Glu Ile Ala Ala Val Asn 
625                 630                 635                 640 


Gly Pro Ser Ser Val Val Leu Ser Gly Asp Glu Thr Ala Val Leu Gln 
                645                 650                 655     


Val Ala Ala Gly Leu Gly Gly Lys Ser Thr Arg Leu Arg Thr Ser His 
            660                 665                 670         


Ala Phe His Ser Ala Arg Met Glu Pro Met Leu Asp Gln Phe Arg Gln 
        675                 680                 685             


Val Ala Glu Gln Leu Thr Tyr Arg Ser Pro Val Ile Glu Met Ala Ala 
    690                 695                 700                 


Gly Val Thr Pro Asp Tyr Trp Val Arg Gln Val Arg Asp Thr Val Arg 
705                 710                 715                 720 


Phe Gly Asp Gln Val Arg Val His Gln Gly Ser Val Leu Val Glu Ile 
                725                 730                 735     


Gly Pro Asp Arg Thr Leu Ala Arg Leu Ile Asp Gly Ile Ala Thr Ser 
            740                 745                 750         


His Gly Asp Asp Glu Val Gln Ala Ala Met Thr Ala Leu Ala Glu Leu 
        755                 760                 765             


His Val Arg Gly Val Ala Val Asp Trp Pro Gly Thr Thr Ser Ala Arg 
    770                 775                 780                 


Val Leu Asp Leu Pro Thr Tyr Ala Phe Gln His Gln Arg Tyr Trp Thr 
785                 790                 795                 800 


Val Ser Trp Leu Ala Gly Leu Thr Pro Glu Glu Arg Glu Gly Ala Leu 
                805                 810                 815     


Val Lys Val Val Arg Asp Ser Ala Ala Val Val Leu Gly His Ala Asp 
            820                 825                 830         


Ala Gly Thr Ile Pro Val Thr Ala Ala Phe Lys Asp Leu Gly Leu Asp 
        835                 840                 845             


Ser Leu Thr Ala Val Glu Leu Arg Asn Ser Leu Ala Arg Ser Thr Gly 
    850                 855                 860                 


Leu Arg Leu Pro Ala Thr Met Val Phe Asp Tyr Pro Thr Leu Gly Ala 
865                 870                 875                 880 


Leu Ala Ala Arg Leu Asp 
                885     


<210>  124
<211>  914
<212>  PRT
<213>  Actinoplanes sp.

<400>  124

Glu Pro Leu Ala Ile Val Gly Met Ala Cys Arg Leu Pro Gly Gly Val 
1               5                   10                  15      


Thr Ser Pro Glu Asp Leu Trp Arg Leu Val Glu Ser Gly Thr Asp Ala 
            20                  25                  30          


Val Ser Ala Phe Pro Ala Asp Arg Gly Trp Asp Ala Asp Ala Leu Tyr 
        35                  40                  45              


Asp Pro Asp Pro Glu Ala Ala Gly Lys Thr Tyr Cys Val Arg Gly Gly 
    50                  55                  60                  


Phe Leu Asp Gly Val Ala Gly Phe Asp Ala Ser Phe Phe Gly Ile Ser 
65                  70                  75                  80  


Pro Arg Glu Ala Leu Ala Met Asp Pro Gln Gln Arg Leu Ile Leu Glu 
                85                  90                  95      


Ala Ser Trp Glu Ala Phe Glu Arg Ala Gly Ile Glu Pro Gly Ser Val 
            100                 105                 110         


Arg Gly Ser Asp Thr Gly Val Phe Met Gly Ala Phe Pro Gly Ser Tyr 
        115                 120                 125             


Gly Val Asp Ala Asp Leu Gly Gly Phe Gly Met Thr Gly Gly Ala Ala 
    130                 135                 140                 


Ser Val Leu Ser Gly Arg Val Ser Tyr Phe Phe Gly Leu Glu Gly Pro 
145                 150                 155                 160 


Ala Met Thr Val Asp Thr Val Cys Ser Ser Ser Leu Val Ala Leu His 
                165                 170                 175     


Gln Ala Gly His Ala Leu Arg Gln Gly Glu Cys Ser Leu Ala Leu Val 
            180                 185                 190         


Gly Gly Val Thr Val Met Ser Thr Pro Asp Thr Phe Val Glu Phe Ser 
        195                 200                 205             


Arg Gln Arg Gly Leu Ala Ala Asp Gly Arg Cys Lys Ala Phe Gly Asp 
    210                 215                 220                 


Gly Ala Asp Gly Thr Gly Trp Ala Glu Gly Ala Gly Val Leu Leu Val 
225                 230                 235                 240 


Glu Arg Leu Ser Asp Ala Gln Ala Lys Gly His Arg Ile Leu Ala Val 
                245                 250                 255     


Val Arg Gly Ser Ala Val Asn Gln Asp Gly Ala Ser Asn Gly Leu Thr 
            260                 265                 270         


Ala Pro Asn Gly Pro Ser Gln Gln Arg Val Ile Arg Ser Ala Leu Ala 
        275                 280                 285             


Asn Ala Gly Leu Ser Ser Ala Asp Val Asp Val Val Glu Ala His Gly 
    290                 295                 300                 


Thr Gly Thr Lys Leu Gly Asp Pro Ile Glu Ala Gln Ala Val Leu Asp 
305                 310                 315                 320 


Thr Tyr Gly Gln Asp Arg Glu Arg Pro Leu Leu Leu Gly Ser Leu Lys 
                325                 330                 335     


Ser Asn Val Gly His Thr Gln Ala Ala Ala Gly Val Ser Gly Val Ile 
            340                 345                 350         


Lys Met Val Met Ala Leu Gln His Gly Val Val Pro Arg Thr Leu His 
        355                 360                 365             


Ala Asp Val Pro Ser Arg Gln Val Asp Trp Thr Ala Gly Ala Val Glu 
    370                 375                 380                 


Leu Val Thr Glu Asn Arg Ser Trp Pro Glu Ala Asp Arg Pro Arg Arg 
385                 390                 395                 400 


Ala Ala Val Ser Ser Phe Gly Leu Ser Gly Thr Asn Ala His Val Ile 
                405                 410                 415     


Leu Glu Ser Pro Pro Asp Gln Pro Thr Thr Ala Ser Ala Pro Thr Thr 
            420                 425                 430         


Gly Pro Val Pro Leu Pro Ile Ser Ala Lys Thr Pro Ala Ala Leu Ala 
        435                 440                 445             


Asp Leu Glu Thr Arg Leu Arg Ala Tyr Leu Thr Pro Glu Thr Asp Leu 
    450                 455                 460                 


Pro Ala Val Ala Ala Thr Leu Ala Val Asn Arg Ser Leu Phe Glu His 
465                 470                 475                 480 


Arg Ala Val Leu Ile Gly Asp Asp Thr Ile Thr Gly Thr Ala Ser Thr 
                485                 490                 495     


Glu Pro Arg Val Val Phe Val Phe Pro Gly Gln Gly Trp His Trp Leu 
            500                 505                 510         


Gly Met Gly Ser Ala Leu Leu Ala Ser Ser Ala Val Phe Ala Asp Arg 
        515                 520                 525             


Met Ala Glu Cys Asn Ala Ala Leu Ser Glu Phe Val Asp Trp Asp Leu 
    530                 535                 540                 


Phe Thr Ala Leu Asp Asp Pro Ala Val Phe Asp Arg Val Asp Val Val 
545                 550                 555                 560 


Gln Pro Thr Cys Trp Ala Val Met Val Ser Leu Ala Ala Val Trp Gln 
                565                 570                 575     


His Ala Gly Val Arg Pro Asp Ala Val Leu Gly His Ser Gln Gly Glu 
            580                 585                 590         


Ile Ala Ala Ala Cys Phe Ala Gly Ala Ile Ser Leu Gln Asp Ala Ala 
        595                 600                 605             


Arg Ile Val Ala Leu Arg Ser Arg Leu Ile Gly Arg Leu Ala Gly Arg 
    610                 615                 620                 


Gly Ala Met Ala Ser Val Ser Leu Pro Pro Asp Glu Ile Pro Leu Ile 
625                 630                 635                 640 


Asp Gly Val Thr Val Ala Val Leu Asn Gly Pro Ser Ala Val Ile Ala 
                645                 650                 655     


Gly Ala Pro Asp Ala Val Asp Ala Val Leu Ala Asp Cys Glu Ala Arg 
            660                 665                 670         


Gly Ala Arg Val Arg Lys Ile Asn Val Asp Tyr Ala Ser His Thr Pro 
        675                 680                 685             


His Val Glu Gln Ile Arg Thr Glu Leu Leu Asp Ile Thr Ala Gly Ile 
    690                 695                 700                 


Thr Ala Glu Thr Pro Thr Val Pro Trp Leu Ser Thr Val Asp Gly Thr 
705                 710                 715                 720 


Trp Ile Asp Arg Pro Leu Asp Thr Glu Tyr Trp Tyr Arg Asn Leu Arg 
                725                 730                 735     


Glu Pro Val Gly Phe Gly Ala Thr Ile Glu Leu Leu Gln Ala Gln Gly 
            740                 745                 750         


Asp Thr Ile Phe Ile Glu Val Ser Ala Ser Pro Val Leu Leu Gln Ala 
        755                 760                 765             


Ile Asp Asp Ser Ile Ala Ile Pro Thr Leu Arg Arg Asp Asp Gly Thr 
    770                 775                 780                 


Pro Thr Arg Leu Leu Thr Ala Leu Ala Glu Ala His Val His Gly Val 
785                 790                 795                 800 


Thr Ile Asp Trp Ala Lys Leu Leu Gly Ser Thr Ala Ser Pro Val Asn 
                805                 810                 815     


Leu Pro Thr Tyr Ala Phe Gln Arg Gln Arg Tyr Trp Ala Ala Ser Ala 
            820                 825                 830         


Ala Ala Gly Arg Pro Ala Glu Leu Thr Pro Glu His Leu Leu Lys Val 
        835                 840                 845             


Val Arg Asp Ser Ala Ala Val Val Leu Gly His Thr Asp Ala Gly Ala 
    850                 855                 860                 


Ile Pro Ala Thr Ala Ala Phe Gln Ala Leu Gly Val Asp Ser Leu Ile 
865                 870                 875                 880 


Ala Val Glu Leu Arg Asn Asn Leu Ala Lys Ser Thr Gly Leu Arg Leu 
                885                 890                 895     


Pro Ala Thr Leu Ile Phe Asp Tyr Pro Thr Pro Ala Asp Leu Ala Thr 
            900                 905                 910         


His Leu 
        


<210>  125
<211>  948
<212>  PRT
<213>  Actinoplanes sp.

<400>  125

Glu Pro Leu Ala Ile Ile Gly Met Ala Cys Arg Leu Pro Gly Gly Ile 
1               5                   10                  15      


Thr Ser Pro Glu Asp Leu Trp Arg Leu Val Glu Ser Gly Ser Asp Ala 
            20                  25                  30          


Ile Ser Asp Phe Pro Asp Asp Arg Gly Trp Asp Val Asp Arg Leu Phe 
        35                  40                  45              


Asp Pro Asp Pro Asp Ala Ala Gly Lys Thr Tyr Thr Thr Gln Gly Gly 
    50                  55                  60                  


Phe Leu Ser Glu Val Ala Gly Phe Asp Ala Ser Phe Phe Gly Ile Ser 
65                  70                  75                  80  


Pro Arg Glu Ala Val Ala Met Asp Pro Gln Gln Arg Leu Val Leu Glu 
                85                  90                  95      


Val Ala Trp Glu Ala Phe Glu Arg Ala Gly Ile Glu Pro Gly Thr Val 
            100                 105                 110         


Arg Gly Ser Asp Thr Gly Val Phe Met Gly Ala Tyr Pro Asp Gly Tyr 
        115                 120                 125             


Gly Ser Gly Thr Asp Leu Ala Gly Phe Gly Val Thr Ala Gly Ala Gly 
    130                 135                 140                 


Ser Val Leu Ser Gly Arg Val Ser Tyr Phe Phe Gly Leu Glu Gly Pro 
145                 150                 155                 160 


Ala Met Thr Val Asp Thr Ala Cys Ser Ser Ser Leu Val Ala Leu His 
                165                 170                 175     


Gln Ala Gly Ser Ala Leu Arg Gln Gly Glu Cys Ser Leu Ala Leu Val 
            180                 185                 190         


Gly Gly Val Thr Val Met Pro Thr Pro Arg Thr Phe Val Glu Phe Ser 
        195                 200                 205             


Arg Gln Arg Gly Leu Ala Ala Asp Gly Arg Cys Lys Pro Phe Ala Asp 
    210                 215                 220                 


Ala Ala Asp Gly Thr Gly Phe Ser Glu Gly Ala Gly Met Leu Val Val 
225                 230                 235                 240 


Glu Arg Leu Ser Asp Ala Gln Thr Asn Gly His His Ile Leu Ala Val 
                245                 250                 255     


Val Arg Ala Ser Ala Val Asn Gln Asp Gly Ala Ser Asn Gly Leu Thr 
            260                 265                 270         


Ala Pro Asn Gly Pro Ser Gln Gln Arg Val Ile Gln Ser Ala Leu Ala 
        275                 280                 285             


Gly Ala Gly Leu Val Ser Ala Asp Ile Asp Val Ile Glu Ala His Gly 
    290                 295                 300                 


Thr Gly Thr Thr Leu Gly Asp Pro Ile Glu Ala Gln Ala Val Ile Ala 
305                 310                 315                 320 


Thr Tyr Gly Gln Asp Arg Ser Gln Pro Val Leu Leu Gly Ser Leu Lys 
                325                 330                 335     


Ser Asn Ile Gly His Thr Gln Ala Ala Ala Gly Val Ser Gly Val Ile 
            340                 345                 350         


Lys Met Val Met Ala Leu Gln His Asp Thr Val Pro Ala Thr Leu His 
        355                 360                 365             


Val Asp Glu Pro Ser Arg His Val Asp Trp Thr Ala Gly Ala Val Ala 
    370                 375                 380                 


Leu Val Thr Glu Asn Gln Pro Trp Pro Arg Asn Gly His Ala Arg Arg 
385                 390                 395                 400 


Ala Gly Val Ser Ser Phe Gly Val Ser Gly Thr Asn Ala His Val Ile 
                405                 410                 415     


Ile Glu Glu Ala Pro Ala Glu Pro Pro Val Glu Pro Val Pro Ala Ala 
            420                 425                 430         


Asp Val Val Val Pro Leu Val Val Ser Ala Arg Asp Ala Ile Pro Leu 
        435                 440                 445             


Gly Asp Gln Ala Ala Arg Leu Ala Ala Leu Val Glu Ala Pro Asp Gly 
    450                 455                 460                 


Pro Val Leu Pro Ala Leu Ala Asp Ala Leu Leu Thr Arg Arg Thr Thr 
465                 470                 475                 480 


Phe Ala Gln Arg Ala Val Val Val Ala Gly Ser Arg Asp Asp Ala Ala 
                485                 490                 495     


Ala Gly Leu Arg Ala Leu Ala Thr Gly Thr Ala His Pro Ala Leu Val 
            500                 505                 510         


Thr Gly Ala Ala Gly Thr Ser Gly Arg Val Val Leu Met Phe Pro Gly 
        515                 520                 525             


Gln Gly Ser Gln Trp Asp Gly Met Gly Ala Gln Leu Ile Gly Ala Ser 
    530                 535                 540                 


Pro Val Phe Ala Ala Arg Ile Ala Asp Cys Ala Ala Ala Leu Gln Pro 
545                 550                 555                 560 


Trp Ile Asp Trp Asp Leu Gln Asp Val Leu Arg Gly Asn Ala Pro Thr 
                565                 570                 575     


Asp Leu Leu Glu Arg Val Asp Val Val Gln Pro Ala Ser Phe Ala Val 
            580                 585                 590         


Met Val Gly Leu Ala Ala Val Trp Glu Ser Val Gly Val Arg Pro Asp 
        595                 600                 605             


Ala Val Leu Gly His Ser Gln Gly Glu Ile Ala Ala Ala Tyr Val Ala 
    610                 615                 620                 


Gly Ala Leu Thr Leu Ala Asp Ala Ala Lys Val Val Ala Val Arg Ser 
625                 630                 635                 640 


Arg Leu Ile Ala Ala Arg Leu Gly Arg Gly Gly Met Ala Ser Val Ala 
                645                 650                 655     


Leu Ser Pro Gln Asp Ala Ala Ala Arg Arg Gly Arg Ala Glu Leu Ala 
            660                 665                 670         


Ala Val Asn Ser Pro Ala Ser Val Val Leu Ala Gly Ala Ser Glu Ala 
        675                 680                 685             


Leu Asp Glu Thr Leu Ala Ala Leu Glu Ala Asp Gly Val Arg Val Arg 
    690                 695                 700                 


Arg Val Ala Val Asp Tyr Ala Ser His Thr Gly His Val Glu Glu Leu 
705                 710                 715                 720 


Glu Gln Asp Leu Ala Glu Ala Leu Ala Asp Val Arg Ser Gln Ala Pro 
                725                 730                 735     


Leu Val Gly Phe Arg Ser Thr Val Thr Gly Glu Trp Val Thr Glu Ala 
            740                 745                 750         


Gly Ala Leu Asp Gly Gly Tyr Trp Tyr Arg Asn Leu Arg Gln Gln Val 
        755                 760                 765             


Arg Phe Gly Pro Ala Val Ala Ala Leu Ala Glu Asp Gly Tyr Ser Val 
    770                 775                 780                 


Phe Val Glu Ala Ser Ala His Pro Val Leu Val Gln Pro Val Thr Glu 
785                 790                 795                 800 


Thr Leu Asp Arg Thr Asp Ala Val Val Thr Gly Ser Leu Arg Arg Gln 
                805                 810                 815     


Asp Gly Gly Leu Ser Arg Leu Leu Thr Ser Val Ala Glu Val Phe Val 
            820                 825                 830         


Gly Gly Val Pro Val Asp Trp Ala Gly Leu Leu Pro Ala Gly Ala Gly 
        835                 840                 845             


Arg Ser Trp Val Asp Leu Pro Thr Tyr Ala Phe Asp His Gln His Tyr 
    850                 855                 860                 


Trp Leu Pro Ala Gly Gly Thr Arg Gly Arg Ser Glu Ala Glu Leu Leu 
865                 870                 875                 880 


Glu Leu Val Arg Gly Arg Ala Ala Ala Val Leu Gly His Thr Asp Ala 
                885                 890                 895     


Gly Ser Ile Pro Ala Thr Ala Ala Phe Lys Asp Leu Gly Leu Asp Ser 
            900                 905                 910         


Leu Thr Ala Val Glu Leu Arg Asn Ser Leu Ala Lys Ser Thr Gly Leu 
        915                 920                 925             


Arg Leu Pro Ala Thr Met Val Phe Asp Tyr Pro Thr Pro Ala Ala Val 
    930                 935                 940                 


Ala Ala Arg Leu 
945             


<210>  126
<211>  866
<212>  PRT
<213>  Actinoplanes sp.

<400>  126

Glu Pro Leu Ala Ile Val Gly Met Ala Cys Arg Leu Pro Gly Gly Ile 
1               5                   10                  15      


Thr Ser Pro Glu Asp Leu Trp Arg Leu Val Ala Ser Gly Ser Asp Ala 
            20                  25                  30          


Ile Ser Asp Leu Pro Val Asp Arg Gly Trp Thr Val Asp Gly His Phe 
        35                  40                  45              


Gln Gly Gly Phe Leu Asp Glu Val Ala Gly Phe Asp Ala Ser Phe Phe 
    50                  55                  60                  


Gly Ile Ser Pro Arg Glu Ala Val Ala Met Asp Pro Gln Gln Arg Leu 
65                  70                  75                  80  


Val Leu Glu Val Ala Trp Glu Ala Phe Glu Arg Ala Gly Ile Glu Pro 
                85                  90                  95      


Gly Ser Val Arg Gly Thr Asp Ala Gly Val Phe Met Gly Ala Tyr Ala 
            100                 105                 110         


Asp Gly Tyr Gly Met Gly Thr Asp Leu Gly Gly Phe Gly Met Thr Ser 
        115                 120                 125             


Val Ala Val Ser Val Leu Ala Gly Arg Ile Ser Tyr Phe Phe Gly Leu 
    130                 135                 140                 


Glu Gly Pro Ala Met Thr Val Asp Thr Ala Cys Ser Ser Ser Leu Val 
145                 150                 155                 160 


Ala Leu His Gln Ala Gly His Ala Leu Arg Gln Gly Glu Cys Ser Leu 
                165                 170                 175     


Ala Leu Val Gly Gly Val Thr Val Met Pro Thr Pro Gln Thr Phe Val 
            180                 185                 190         


Glu Phe Asp Arg Gln Arg Gly Leu Ala Ala Asp Gly Arg Cys Lys Ala 
        195                 200                 205             


Phe Ala Asp Ala Ala Asp Gly Thr Ser Phe Ser Glu Gly Ala Gly Met 
    210                 215                 220                 


Leu Val Val Glu Arg Leu Ser Asp Ala Leu Ala Asn Gly His His Ile 
225                 230                 235                 240 


Leu Ala Val Val Arg Gly Ser Ala Val Asn Gln Asp Gly Ala Ser Asn 
                245                 250                 255     


Gly Leu Thr Ala Pro Asn Gly Pro Ser Gln Gln Arg Val Ile Arg Ser 
            260                 265                 270         


Ala Leu Ala Asn Ala Gly Leu Thr Thr Ala Asp Val Asp Val Val Glu 
        275                 280                 285             


Ala His Gly Thr Gly Thr Thr Leu Gly Asp Pro Ile Glu Ala Gln Ala 
    290                 295                 300                 


Val Ile Ala Thr Tyr Gly Gln Asn Arg Gln Arg Pro Leu Leu Leu Gly 
305                 310                 315                 320 


Ser Leu Lys Ser Asn Ile Gly His Thr Gln Ala Ala Ala Gly Val Ser 
                325                 330                 335     


Gly Val Ile Lys Met Val Met Ala Leu Arg Asn Gly Thr Val Pro Ala 
            340                 345                 350         


Thr Leu His Val Asp Glu Pro Ser Arg His Ile Asp Trp Thr Ala Gly 
        355                 360                 365             


Ala Val Ala Leu Val Thr Glu Asn Gln Pro Trp Pro Glu Thr Glu Arg 
    370                 375                 380                 


Pro Arg Arg Ala Gly Val Ser Ser Phe Gly Ile Ser Gly Thr Asn Ala 
385                 390                 395                 400 


His Val Ile Leu Glu Ser Thr Pro Thr Pro Pro Ala Thr Leu Ser Ala 
                405                 410                 415     


Gln Val Ala His Pro Leu Pro Leu Pro Ile Ser Ala Lys Thr Pro Pro 
            420                 425                 430         


Ala Leu Ala Asp Leu Glu Ala Arg Leu Arg Ala Tyr Leu Thr Pro Glu 
        435                 440                 445             


Ala Asp Leu Ala Ala Val Ala Ser Thr Leu Ala Ser Thr Arg Ala Val 
    450                 455                 460                 


Phe Glu His Arg Ala Val Leu Leu Gly Asp Glu Thr Ile Val Gly Val 
465                 470                 475                 480 


Ala Ala Leu Asp Pro Arg Val Val Phe Val Phe Ser Gly Gln Gly Ser 
                485                 490                 495     


Gln Arg Ala Gly Met Gly Glu Gln Leu Ala Ala Val Phe Pro Val Phe 
            500                 505                 510         


Ala Gln Ile His Arg Glu Val Leu Asp Leu Leu Asp Ile Pro Asp Leu 
        515                 520                 525             


Asp Ile Asp Gln Thr Gly His Ala Gln Pro Ala Leu Phe Ala Phe Gln 
    530                 535                 540                 


Val Ala Leu Ala Gly Leu Leu Asp Ser Trp Gly Val Arg Pro Asp Ala 
545                 550                 555                 560 


Val Ile Gly His Ser Ile Gly Glu Leu Ala Ala Ala Tyr Val Ala Gly 
                565                 570                 575     


Leu Trp Ser Leu Gln Asp Ala Cys Ala Leu Val Ser Ala Arg Ala Arg 
            580                 585                 590         


Leu Met Gln Ala Leu Pro Ser Gly Gly Ala Met Val Ala Val Ala Val 
        595                 600                 605             


Pro Glu Asp Glu Ala Arg Ala Val Leu Ile Asp Gly Val Glu Ile Ala 
    610                 615                 620                 


Ala Val Asn Gly Pro Ser Ser Val Val Leu Ser Gly Asp Glu Thr Ala 
625                 630                 635                 640 


Val Leu Gln Val Ala Glu Ser Leu Gly Gly Lys Ser Ala Arg Leu Lys 
                645                 650                 655     


Thr Ser His Ala Phe His Ser Ala Arg Met Glu Pro Met Leu Asp Gln 
            660                 665                 670         


Phe Arg Gln Val Ala Glu Gln Leu Thr Tyr Arg Ser Pro Val Ile Glu 
        675                 680                 685             


Met Thr Ala Gly Val Thr Pro Asp Tyr Trp Val Arg Gln Val Arg Asp 
    690                 695                 700                 


Thr Val Arg Phe Gly Asp Gln Val Arg Val His Gln Gly Ser Val Leu 
705                 710                 715                 720 


Val Glu Ile Gly Pro Asp Arg Thr Leu Ala Arg Leu Ile Asp Gly Ile 
                725                 730                 735     


Ala Thr Ser His Gly Asp Asp Glu Val Gln Ala Val Met Thr Ala Leu 
            740                 745                 750         


Ala Glu Leu His Val Arg Gly Val Ala Val Asp Trp Pro Gly Thr Thr 
        755                 760                 765             


Ser Ala Arg Val Leu Asp Leu Pro Thr Tyr Ala Phe Gln His Asp His 
    770                 775                 780                 


Tyr Trp Ala His Pro Val Asp Arg Thr Pro Glu Ala Leu Leu Ala Leu 
785                 790                 795                 800 


Val Arg Asp Ser Ala Ala Val Ala Leu Gly His Ala Gly Ala Ala Thr 
                805                 810                 815     


Val Pro Ala Thr Ala Ala Phe Gln Ser Leu Gly Met Asp Ser Leu Ile 
            820                 825                 830         


Ala Val Glu Leu Arg Asn Asn Leu Ala Arg Ser Thr Gly Leu Arg Leu 
        835                 840                 845             


Pro Ala Thr Leu Val Phe Asp Tyr Pro Thr Pro Ala Ala Leu Ala Thr 
    850                 855                 860                 


Arg Leu 
865     


<210>  127
<211>  901
<212>  PRT
<213>  Actinoplanes sp.

<400>  127

Glu Pro Leu Ala Ile Val Gly Met Ala Cys Arg Leu Pro Gly Gly Val 
1               5                   10                  15      


Thr Ser Pro Glu Asp Leu Trp Arg Leu Val Ala Ser Gly Thr Asp Ala 
            20                  25                  30          


Ile Thr Gly Leu Pro Thr Asp Arg Gly Trp Glu Glu Asp Asp Arg Phe 
        35                  40                  45              


Arg Gly Gly Phe Leu Ala Gly Val Ala Gly Phe Asp Ala Ser Phe Phe 
    50                  55                  60                  


Gly Ile Ser Pro Arg Glu Ala Val Ala Met Asp Pro Gln Gln Arg Leu 
65                  70                  75                  80  


Val Leu Glu Ala Ser Trp Glu Ala Phe Glu Arg Ala Gly Ile Glu Pro 
                85                  90                  95      


Gly Ser Val Arg Gly Ser Asp Thr Gly Val Phe Met Gly Ala Tyr Pro 
            100                 105                 110         


Gly Gly Tyr Gly Phe Gly Ala Asp Leu Gly Gly Phe Ala Leu Thr Ser 
        115                 120                 125             


Gly Ser Gly Ser Val Leu Ser Gly Arg Val Ser Tyr Phe Phe Gly Leu 
    130                 135                 140                 


Glu Gly Pro Ala Met Thr Val Asp Thr Ala Cys Ser Ser Ser Leu Val 
145                 150                 155                 160 


Ala Leu His Gln Ala Gly Tyr Ala Leu Arg Gln Gly Glu Cys Ser Leu 
                165                 170                 175     


Ala Leu Val Gly Gly Val Thr Ile Met Pro Thr Pro Gln Thr Phe Ile 
            180                 185                 190         


Glu Phe Glu Arg Gln Arg Gly Leu Ala Ala Asp Gly Arg Ser Lys Ala 
        195                 200                 205             


Phe Ala Asp Ser Ala Asp Gly Thr Gly Trp Ser Glu Gly Val Gly Val 
    210                 215                 220                 


Leu Val Val Glu Arg Leu Ser Asp Ala Gln Ala Asn Gly His His Ile 
225                 230                 235                 240 


Leu Ala Val Val Arg Gly Ser Ala Ile Asn Gln Asp Gly Ala Ser Asn 
                245                 250                 255     


Gly Leu Thr Ala Pro Asn Gly Pro Ser Gln Gln Arg Val Ile Arg Ser 
            260                 265                 270         


Ala Leu Ala Asn Ala Gly Leu Thr Thr Ala Asp Ile Asp Val Ile Glu 
        275                 280                 285             


Ala His Gly Thr Gly Thr Thr Leu Gly Asp Pro Ile Glu Ala Gln Ala 
    290                 295                 300                 


Val Ile Ala Thr Tyr Gly Gln Asp Arg Ser Gln Pro Val Leu Leu Gly 
305                 310                 315                 320 


Ser Leu Lys Ser Asn Ile Gly His Thr Gln Ala Ala Ala Gly Val Ser 
                325                 330                 335     


Gly Val Ile Lys Met Val Met Ala Leu Gln His Asp Thr Val Pro Ala 
            340                 345                 350         


Thr Leu His Val Asp Arg Pro Ser Arg His Val Asp Trp Ala Ala Gly 
        355                 360                 365             


Ala Val Glu Leu Val Thr Glu Asn Arg Pro Trp Pro Glu Asn Gly Arg 
    370                 375                 380                 


Val Arg Arg Ala Gly Val Ser Ala Phe Gly Val Ser Gly Thr Asn Ala 
385                 390                 395                 400 


His Val Ile Leu Glu Ser Pro Pro Asp Gln Pro Val Lys Pro Ser Ala 
                405                 410                 415     


Pro Ala Ala Gly Pro Val Pro Leu Pro Ile Ser Ala Lys Thr Pro Ala 
            420                 425                 430         


Ala Leu Ala Ala Leu Glu Asn Arg Leu Arg Ala Tyr Leu Thr Pro Glu 
        435                 440                 445             


Thr Asp Leu Pro Ala Val Ala Ser Thr Leu Ala Thr Thr Arg Ala Met 
    450                 455                 460                 


Phe Glu His Arg Ala Val Leu Leu Gly Asp Asp Thr Ile Thr Gly Thr 
465                 470                 475                 480 


Ala Ser Thr Glu Pro Arg Val Val Phe Val Phe Pro Gly Gln Gly Trp 
                485                 490                 495     


His Trp Leu Gly Met Gly Ser Ala Leu Leu Ala Ser Ser Ala Val Phe 
            500                 505                 510         


Ala Asp Arg Met Ala Glu Cys Asn Ala Ala Leu His Glu Phe Val Asp 
        515                 520                 525             


Trp Asp Leu Phe Thr Ala Leu Asp Asp Pro Ala Val Phe Asp Arg Val 
    530                 535                 540                 


Asp Ile Val Gln Pro Thr Cys Trp Ala Val Met Met Ser Leu Ala Ala 
545                 550                 555                 560 


Leu Trp Gln His Ala Gly Val Arg Pro Asp Ala Val Leu Gly His Ser 
                565                 570                 575     


Gln Gly Glu Ile Ala Ala Ala Cys Phe Ala Gly Ala Ile Ser Leu Gln 
            580                 585                 590         


Asp Ala Ala Arg Ile Val Ala Leu Arg Ser Gln Leu Ile Gly Arg Leu 
        595                 600                 605             


Ala Gly Arg Gly Ala Met Ala Ser Val Ser Leu Pro Pro Asp Glu Ile 
    610                 615                 620                 


Pro Leu Ile Asp Gly Val Thr Val Ala Val Leu Asn Gly Pro Ser Ala 
625                 630                 635                 640 


Val Ile Ala Gly Ser Pro Glu Ala Val Asp Ala Val Leu Ala Asp Cys 
                645                 650                 655     


Glu Ala Arg Gly Ala Arg Val Arg Lys Ile Asn Val Asp Tyr Ala Ser 
            660                 665                 670         


His Thr Pro His Val Glu Gln Ile Arg Thr Glu Leu Leu His Ile Thr 
        675                 680                 685             


Ala Ala Ile Thr Ala Glu Thr Pro Thr Val Pro Trp Leu Ser Thr Val 
    690                 695                 700                 


Asp Gly Thr Trp Ile Asp His Pro Leu Asp Thr Glu Tyr Trp Tyr Arg 
705                 710                 715                 720 


Asn Leu Arg Glu Pro Val Gly Phe Gly Ala Thr Ile Glu Leu Leu Gln 
                725                 730                 735     


Thr Gln Gly Asp Thr Ile Phe Ile Glu Val Ser Ala Ser Pro Val Leu 
            740                 745                 750         


Leu Gln Ala Ile Asp Asp Ser Ile Ala Ile Pro Thr Leu Arg Arg Asp 
        755                 760                 765             


Asp Gly Thr Pro Thr Arg Leu Leu Thr Ala Leu Ala Glu Ala His Val 
    770                 775                 780                 


Asn Gly Val Thr Ile Asp Trp Ala Thr Val Leu Gly Ala Thr Gly Ser 
785                 790                 795                 800 


Pro Val Asp Leu Pro Thr Tyr Ala Phe Gln His Gln Arg Phe Trp Val 
                805                 810                 815     


Gly Asp Arg Leu His Gly Arg Thr Ser Ala Glu Gln His Arg Ile Met 
            820                 825                 830         


Leu Asp Leu Val Leu Gly His Ala Thr Ser Val Leu Gly His Gln Thr 
        835                 840                 845             


Pro Asp Ala Val Ala Ser Asp Arg Ala Phe Lys Asp Leu Gly Met Asp 
    850                 855                 860                 


Ser Leu Thr Ala Val Glu Leu Arg Asn His Leu Val Ala Glu Thr Gly 
865                 870                 875                 880 


Leu Arg Leu Pro Ala Thr Thr Ala Phe Asp His Pro Thr Ala Asp Asp 
                885                 890                 895     


Leu Ala Arg Arg Leu 
            900     


<210>  128
<211>  948
<212>  PRT
<213>  Actinoplanes sp.

<400>  128

Glu Pro Ile Ala Ile Val Ser Met Ala Cys Arg Ala Pro Gly Cys Val 
1               5                   10                  15      


Thr Ser Pro Glu Gly Leu Trp Arg Leu Val Glu Ser Gly Thr Asp Ala 
            20                  25                  30          


Ile Ala Asp Phe Pro Ala Asp Arg Gly Trp Asp Leu Ala Thr Leu Tyr 
        35                  40                  45              


Ser Pro Asp Pro Ile Gly Tyr Thr Ser Tyr Cys Leu Gln Gly Gly Phe 
    50                  55                  60                  


Leu Asp Ala Ala Ala Asp Phe Asp Ala Ala Phe Phe Gly Ile Ser Pro 
65                  70                  75                  80  


Arg Glu Ala Leu Gly Met Asp Pro Gln Gln Arg Leu Leu Leu Glu Thr 
                85                  90                  95      


Ser Trp Glu Ala Ile Glu Arg Ala Arg Ile Asp Pro Arg Ser Leu Arg 
            100                 105                 110         


Gly Arg Asp Val Gly Val Tyr Val Gly Gly Ala Thr Gln Gly Tyr Gly 
        115                 120                 125             


Val Gly Ala Val Asp Gln Gln Arg Asp Asn Val Ile Thr Gly Ser Ser 
    130                 135                 140                 


Ile Ser Leu Leu Ser Gly Arg Leu Ser Tyr Ala Leu Gly Leu Glu Gly 
145                 150                 155                 160 


Pro Gly Val Thr Val Asp Thr Ala Cys Ser Ser Ser Leu Val Ala Leu 
                165                 170                 175     


His Leu Ala Ser Gln Ala Leu Arg Gln Arg Glu Cys Ser Met Ala Leu 
            180                 185                 190         


Val Ser Gly Val Ser Val Ile Pro Thr Pro Asp Val Phe Val Glu Phe 
        195                 200                 205             


Ser Arg Gln Arg Gly Leu Ala Ser Asp Gly Arg Cys Lys Ser Phe Ser 
    210                 215                 220                 


Ala Ala Ala Asp Gly Thr Ile Trp Ala Glu Gly Val Gly Val Leu Val 
225                 230                 235                 240 


Leu Glu Arg Leu Ser Glu Ala Thr Arg Leu Gly His Glu Val Leu Ala 
                245                 250                 255     


Val Ile Arg Gly Ser Ala Val Asn Ser Asp Gly Ala Ser Asn Gly Leu 
            260                 265                 270         


Thr Ala Pro Asn Gly Ala Ser Gln Gln Arg Val Ile Arg Gln Ala Leu 
        275                 280                 285             


Ala Ser Ala Gly Leu Asn Ala Ala Asp Val Asp Thr Val Glu Ala His 
    290                 295                 300                 


Gly Thr Gly Thr Lys Leu Gly Asp Pro Ile Glu Ala Glu Ala Ile Leu 
305                 310                 315                 320 


Ala Thr Tyr Gly Gln Asp Arg Ser Ser Pro Val Trp Leu Gly Ser Leu 
                325                 330                 335     


Lys Ser Asn Ile Gly His Ser Met Ala Ala Ser Gly Val Leu Gly Val 
            340                 345                 350         


Ile Lys Met Val Glu Ala Met Arg His Ala Arg Leu Pro Arg Thr Leu 
        355                 360                 365             


His Val Asp Glu Pro Ser Pro His Val Asp Trp Ala Ser Gly Asp Val 
    370                 375                 380                 


Ala Leu Leu Thr Glu Asn Gln Pro Trp Pro Asp Gly Ala Arg Pro Arg 
385                 390                 395                 400 


Arg Ala Gly Val Ser Ser Phe Gly Leu Ser Gly Thr Asn Ala His Val 
                405                 410                 415     


Val Leu Glu Gln His Arg Ala Pro Ala Val Pro Val Ala Ala Glu Thr 
            420                 425                 430         


Val Ala Asp Asp Val Pro Leu Pro Leu Leu Leu Ser Ala Arg His Pro 
        435                 440                 445             


Lys Ala Leu Arg Asp Gln Ala Ala Arg Leu His Ala Ala Leu Ala Glu 
    450                 455                 460                 


Ala Pro Gly Trp Arg Pro Leu Asp Val Gly Tyr Ser Leu Ala Thr Thr 
465                 470                 475                 480 


Arg Ser Ala Phe Ala His Arg Ala Val Ala Val Gly Ser Gly Arg Glu 
                485                 490                 495     


Leu Leu Arg Ala Leu Ala Lys Leu Ala Glu Gly Ala Ala Trp Pro Ala 
            500                 505                 510         


Leu Val Thr Gly Thr Ala Lys Ala Gly Arg Val Ala Phe Leu Phe Asp 
        515                 520                 525             


Gly Gln Gly Thr Gln Arg Leu Gly Met Gly Arg Val Leu His Asp Arg 
    530                 535                 540                 


Phe Pro Val Phe Ala Arg Ala Trp Asp Thr Val Ser Ala Arg Phe Asp 
545                 550                 555                 560 


Gln His Leu Asp His Ser Leu Thr Asp Val Tyr Leu Gly Arg Asp Thr 
                565                 570                 575     


Ser Ala Ala Ala Leu Ala Asp Asp Thr Leu Tyr Ala Gln Ala Gly Ile 
            580                 585                 590         


Phe Thr Met Glu Val Ala Leu Phe Glu Leu Leu Ala Glu Trp Gly Val 
        595                 600                 605             


Arg Pro Asp Leu Val Ser Gly His Ser Ile Gly Glu Val Ala Ala Ala 
    610                 615                 620                 


Tyr Ala Ala Gly Leu Phe Ser Leu Glu Asp Ala Ala Thr Leu Ile Val 
625                 630                 635                 640 


Ala Arg Gly Arg Ala Leu Arg Gln Met Pro Pro Gly Ala Met Leu Ala 
                645                 650                 655     


Leu Arg Ala Ser Glu Asp Gln Val Arg Glu Leu Leu Asp Arg Thr Gly 
            660                 665                 670         


Ala Asp Leu Asp Val Ala Ala Val Asn Ser Pro Val Ser Val Val Val 
        675                 680                 685             


Ser Gly Asp Pro Asp Ala Val Ala Ala Phe Arg Ala Glu Trp Glu Ala 
    690                 695                 700                 


Ser Glu Arg Asp Ala Arg Ala Leu Asn Val His His Ala Phe His Ser 
705                 710                 715                 720 


Arg Arg Val Asp Ala Val Leu Asp Glu Phe Arg Ala Val Leu Gly Thr 
                725                 730                 735     


Leu Thr Phe Arg Thr Pro Ala Leu Pro Val Val Ser Thr Val Thr Gly 
            740                 745                 750         


Arg Leu Ala Gly Pro Ala Glu Met Ser Thr Pro Glu Tyr Trp Leu Arg 
        755                 760                 765             


Gln Ile Arg Arg Thr Val Arg Phe Gln Asp Ala Val Arg Glu Leu Ser 
    770                 775                 780                 


Gly Gln Gly Ala Gly Thr Phe Val Glu Ile Gly Pro Ser Gly Ala Leu 
785                 790                 795                 800 


Ala Ala Ala Gly Leu Glu Cys Val Asp Ala Ser Phe His Ala Val Gln 
                805                 810                 815     


Arg Pro Arg Ser Pro Glu Asp Ala Cys Leu Leu Thr Ala Val Ala Glu 
            820                 825                 830         


Leu His Ala Gly Gly Thr Ala Val Asp Trp Ala Lys Val Leu Ala Gly 
        835                 840                 845             


Gly Arg Ala Thr Asp Leu Pro Val Tyr Pro Phe Gln His Glu Thr Tyr 
    850                 855                 860                 


Trp Ile Pro Pro Ala Ser Pro Pro Ala Asp Thr Arg Thr Met Leu Glu 
865                 870                 875                 880 


Val Val His Glu Glu Ala Ala Leu Val Leu Gly Val Thr Asp Pro Arg 
                885                 890                 895     


Val Ile Leu Asp Asp Ser Ser Phe Leu Asp Leu Gly Phe Asp Ser Leu 
            900                 905                 910         


Ser Ala Met Arg Leu Gly Asn Gln Leu Ser Ala Val Thr Gly Leu Asp 
        915                 920                 925             


Leu Pro Pro Ser Leu Leu Phe Glu His Pro Thr Val Gly Glu Leu Ala 
    930                 935                 940                 


Ala His Leu Asp 
945             


<210>  129
<211>  886
<212>  PRT
<213>  Actinoplanes sp.

<400>  129

Glu Pro Leu Ala Ile Val Gly Met Ala Ala Arg Phe Pro Gly Gly Val 
1               5                   10                  15      


Ala Ser Ala Asp Asp Leu Trp Arg Leu Val Val Ser Gly Gly Asp Ala 
            20                  25                  30          


Ile Gly Gly Phe Pro Ala Asp Arg Gly Trp Asp Leu Glu Glu Leu Tyr 
        35                  40                  45              


Asp Pro Asp Pro Ala Ala Thr Gly Arg Ser Tyr Val Arg Glu Gly Gly 
    50                  55                  60                  


Phe Leu Asn Asp Ala Thr Thr Phe Asp Ala Ser Phe Phe Arg Ile Gly 
65                  70                  75                  80  


Pro Arg Glu Ala Lys Ala Met Asp Pro Gln Gln Arg Leu Leu Leu Glu 
                85                  90                  95      


Thr Ser Trp Glu Ala Phe Glu His Ala Gly Ile Arg Pro Glu Thr Leu 
            100                 105                 110         


Arg Gly Thr Ala Thr Gly Val Phe Ala Gly Ile Ser Leu Gln Asp Tyr 
        115                 120                 125             


Gly Val Leu Ala Gly Ser Asp Pro Glu Leu Glu Gly Tyr Ala Gly Thr 
    130                 135                 140                 


Gly Asn Ala Pro Ser Val Leu Ser Gly Arg Leu Ser Tyr Phe Tyr Gly 
145                 150                 155                 160 


Leu Glu Gly Pro Ala Val Thr Ile Asp Thr Ala Cys Ser Ser Ser Leu 
                165                 170                 175     


Val Ala Leu His Leu Ala Gly Gln Ser Leu Arg Arg Asp Glu Cys Thr 
            180                 185                 190         


Leu Ala Val Val Gly Gly Val Thr Val Met Pro Ser Pro Asn Val Phe 
        195                 200                 205             


Val Glu Phe Ser Arg Gln Arg Gly Leu Ala Pro Asp Gly Arg Cys Lys 
    210                 215                 220                 


Pro Phe Ala Ala Ala Ala Asp Gly Thr Gly Trp Ser Glu Gly Val Gly 
225                 230                 235                 240 


Val Leu Val Val Glu Arg Leu Ser Asp Ala Arg Arg Asn Lys Arg Arg 
                245                 250                 255     


Ile Leu Ala Val Val Arg Gly Ser Ala Val Asn Gln Asp Gly Ala Ser 
            260                 265                 270         


Ser Gly Leu Thr Ala Pro Asn Gly Pro Ser Gln Gln Arg Val Ile Arg 
        275                 280                 285             


Ser Ala Leu Ala Ala Ala Gly Leu Thr Ala Gly Asp Val Asp Val Val 
    290                 295                 300                 


Glu Ala His Gly Thr Gly Thr Thr Leu Gly Asp Pro Ile Glu Ala Gln 
305                 310                 315                 320 


Gly Val Leu Ala Thr Tyr Gly Asp Arg Ser Gly Ala Pro Val Arg Leu 
                325                 330                 335     


Gly Ser Val Lys Ser Asn Leu Gly His Thr Gln Ala Ala Ala Gly Ile 
            340                 345                 350         


Ala Gly Val Ile Lys Met Val Gln Ala Leu Arg His Gly Val Met Pro 
        355                 360                 365             


Arg Ser Leu His Ile Asp Glu Pro Ser Pro His Val Asp Trp Thr Ala 
    370                 375                 380                 


Gly Arg Val Glu Leu Leu Thr Ser Asn Leu Pro Trp Pro Thr Ser Glu 
385                 390                 395                 400 


Arg Pro Arg Arg Ala Ala Val Ser Ser Phe Gly Ile Ser Gly Thr Asn 
                405                 410                 415     


Ala His Val Ile Leu Glu Gln Ala Phe Pro Ala Thr Glu Pro Glu Pro 
            420                 425                 430         


Ser Phe Thr Pro Val Val Ser Gly Pro Ala Leu Pro Leu Val Phe Ser 
        435                 440                 445             


Ala Arg Asp Ser Gly Ala Leu Ala Thr Arg Thr His Leu Ser Asp Gly 
    450                 455                 460                 


Pro Gly Val Ala Tyr Ala Leu Ala Thr Ser Arg Ser Met Phe Asp His 
465                 470                 475                 480 


Arg Ser Val Arg Ile Gly Asp Met Thr Val Thr Gly Val Ala Thr Thr 
                485                 490                 495     


Asp Pro Glu Val Val Phe Val Phe Pro Gly Gln Gly Thr Gln Trp Ala 
            500                 505                 510         


Gly Met Gly Arg Ala Leu Met Asp Ala Ser Pro Val Phe Ala Glu Arg 
        515                 520                 525             


Met Asn Glu Cys Ala Ala Ala Leu Glu Pro Tyr Leu Asp Leu Trp Glu 
    530                 535                 540                 


Ala Ile Asp Thr Pro Asp Gln Val Glu Thr Leu Gln Pro Ala Ser Trp 
545                 550                 555                 560 


Ala Val Met Val Ser Leu Ala Ala Val Trp Gln Ala Ala Gly Val Arg 
                565                 570                 575     


Pro Ala Ala Val Ile Gly His Ser Gln Gly Glu Ile Ala Ala Ala Cys 
            580                 585                 590         


Val Ala Gly Ser Leu Ser Leu Ala Asp Ala Ala Ala Val Val Ala Leu 
        595                 600                 605             


Arg Ser Lys Ala Ile Ala Ala Ser Leu Gly Lys Gly Ala Met Ala Ser 
    610                 615                 620                 


Ile Pro Leu Pro Val Glu Glu Ile Glu Leu Ile Asp Glu Val Trp Val 
625                 630                 635                 640 


Ala Ala Leu Asn Gly Pro Ser Ser Thr Val Val Ala Gly Ala Pro Asp 
                645                 650                 655     


Ala Val Glu Gln Val Arg Ala Arg Tyr Asp Gly Arg Arg Ile Ala Val 
            660                 665                 670         


Asp Tyr Ala Ser His Thr Pro His Val Glu Ala Leu Arg Gly Gln Val 
        675                 680                 685             


Val Ser Val Pro Ser Gln Ala Pro Asp Ile Pro Trp Phe Ser Thr Val 
    690                 695                 700                 


Asp Ser Glu Trp Val Glu Gly Pro Leu Asp Asp Asp Tyr Trp Phe Arg 
705                 710                 715                 720 


Asn Leu Arg Gln Pro Val Gln Phe Gly Pro Ala Ala Ala Arg Phe Asp 
                725                 730                 735     


Asp Ala Val Phe Val Glu Val Ser Ala Arg Pro Val Leu Ile Pro Ala 
            740                 745                 750         


Leu Asp Ala Ser Val Thr Val Pro Ser Leu Arg Arg Asp Asp Gly Gly 
        755                 760                 765             


Pro Glu Arg Met Leu Ala Ser Leu Ala Gln Ala Phe Val Ala Gly Val 
    770                 775                 780                 


Ala Val Asp Trp Thr Thr Ile Val Pro Pro Ala Pro Phe Val Asp Leu 
785                 790                 795                 800 


Pro Thr Tyr Pro Phe Gln Gly Glu Arg Phe Trp Ile Asp Leu Asp Asp 
                805                 810                 815     


Val Leu Ala Val Val Arg Asp Cys Ala Ala Thr Val Leu Gly His Thr 
            820                 825                 830         


Asp Pro Ala Ala Ile Ala Pro Asp Arg Pro Phe Lys Asp Leu Gly Phe 
        835                 840                 845             


Asp Ser Leu Ala Ala Val Gln Leu Arg Asn His Leu Leu Thr Val Thr 
    850                 855                 860                 


Gly Val Arg Leu Ser Ala Thr Ala Val Phe Asp Phe Pro Thr Pro Ala 
865                 870                 875                 880 


Val Leu Ala Gly Glu Val 
                885     


<210>  130
<211>  859
<212>  PRT
<213>  Actinoplanes sp.

<400>  130

Glu Pro Ile Ala Val Val Gly Met Ala Cys Arg Leu Pro Gly Asp Val 
1               5                   10                  15      


Ala Ser Pro Glu Asp Leu Trp Arg Leu Val Ala Glu Gly Arg Asp Ala 
            20                  25                  30          


Val Gly Pro Phe Pro Ala Asp Arg Gly Trp Glu Leu Gly Glu Ala Ala 
        35                  40                  45              


Tyr Ala Arg Val Gly Gly Phe Val Thr Gly Ala Thr Gly Phe Asp Ala 
    50                  55                  60                  


Gly Phe Phe Gly Ile Ser Pro Arg Glu Ala Leu Ala Met Asp Pro Gln 
65                  70                  75                  80  


Gln Arg Leu Leu Leu Glu Val Ala Trp Glu Ala Phe Glu Arg Ala Gly 
                85                  90                  95      


Ile Ala Pro Asp Ala Leu Arg Gly Ser Asp Thr Gly Val Phe Val Gly 
            100                 105                 110         


Thr Tyr Gly Gln Gly Tyr Gly Glu Leu Ala Val Asp Gly Asp Ala Glu 
        115                 120                 125             


Gly Tyr Val Gly Ile Gly Asn Ser Gly Ser Val Val Ser Gly Arg Val 
    130                 135                 140                 


Ser Tyr Phe Phe Gly Leu Glu Gly Pro Ala Val Thr Val Asp Thr Ala 
145                 150                 155                 160 


Cys Ser Ser Ser Leu Val Ala Leu His Gln Ala Ala Gln Ala Leu Arg 
                165                 170                 175     


Gln Gly Glu Cys Ser Leu Ala Leu Val Gly Gly Val Thr Val Met Ser 
            180                 185                 190         


Ser Pro Leu Ile Phe Gln Glu Phe Ala Arg Gln Gly Gly Leu Ala Ala 
        195                 200                 205             


Asp Gly Arg Cys Lys Ala Phe Ala Asp Gly Ala Asp Gly Thr Gly Trp 
    210                 215                 220                 


Gly Glu Gly Val Gly Val Leu Val Val Glu Arg Leu Ser Glu Ala Gln 
225                 230                 235                 240 


Arg Arg Gly His Thr Val Leu Ala Val Val Arg Gly Ser Ala Val Asn 
                245                 250                 255     


Gln Asp Gly Ala Ser Asn Gly Leu Thr Ala Pro Asn Gly Pro Ser Gln 
            260                 265                 270         


Gln Arg Val Ile Arg Ser Ala Leu Ala Ser Ala Gly Leu Gly Phe Gly 
        275                 280                 285             


Asp Val Asp Leu Val Glu Ala His Gly Thr Gly Thr Ala Leu Gly Asp 
    290                 295                 300                 


Pro Ile Glu Ala Gln Ala Leu Leu Ala Thr Tyr Gly Ser Ala Gly Thr 
305                 310                 315                 320 


Pro Val Trp Leu Gly Ser Leu Lys Ser Asn Ile Gly His Thr Gln Ala 
                325                 330                 335     


Ala Ala Gly Val Ala Gly Val Ile Lys Ala Val Glu Ala Met Arg His 
            340                 345                 350         


Gly Val Leu Pro Gln Thr Leu His Ala Asp Gln Pro Ser Ser His Val 
        355                 360                 365             


Asp Trp Thr Ala Gly Ala Val Glu Leu Leu Thr Ala Asn Arg Pro Trp 
    370                 375                 380                 


Asp Ser Ala Gly Arg Pro Arg Arg Ala Ala Val Ser Ser Phe Gly Ile 
385                 390                 395                 400 


Ser Gly Thr Asn Ala His Val Ile Leu Glu Glu Phe Ser Ser Ala Pro 
                405                 410                 415     


Val Ser Pro Glu Pro Gly Ala Gly Ala Ala Pro Leu Leu Leu Ser Ala 
            420                 425                 430         


Arg Ser Ala Ala Ala Leu Ala Glu Phe Glu Ser Arg Val Ala Ala Leu 
        435                 440                 445             


Arg Pro Ser Arg Asp Leu Ala Ala Thr Leu Ala Gly Arg Val Phe Phe 
    450                 455                 460                 


Asp His Arg Ala Val Val Leu Pro Gly Gly Glu Val Val Arg Gly Arg 
465                 470                 475                 480 


Val Gly Asp Ala Pro Val Val Phe Val Phe Ala Gly Gln Gly Ser Gln 
                485                 490                 495     


Arg Ser Asp Met Ala Ser Arg Leu Ala Gly Glu Phe Pro Leu Phe Ala 
            500                 505                 510         


Ala Ala His Glu Arg Val Trp Ser Leu Leu Asp Val Asp Glu Ser Leu 
        515                 520                 525             


Asp Val Asp Gln Thr Gly Phe Ala Gln Pro Ala Leu Phe Ala Tyr Glu 
    530                 535                 540                 


Val Ala Leu Ala Glu Leu Leu Gly Val Arg Pro Asp Ala Val Ile Gly 
545                 550                 555                 560 


His Ser Val Gly Glu Leu Ala Ala Ala Tyr Val Ala Gly Ala Leu Ser 
                565                 570                 575     


Leu Glu Asp Ala Cys Arg Leu Val Ser Ala Arg Ala Arg Leu Met Gln 
            580                 585                 590         


Ala Leu Pro Pro Gly Gly Val Met Val Ser Val Arg Val Ser Glu Glu 
        595                 600                 605             


Ala Ala Arg Ala Val Leu Arg Asp Gly Val Glu Leu Ala Ala Val Asn 
    610                 615                 620                 


Gly Pro Arg Ala Val Val Leu Ser Gly Asp Glu Gly Ala Val Leu Ala 
625                 630                 635                 640 


Ala Ala Ala Glu Leu Gly Glu Phe Arg Arg Leu Arg Thr Ser His Ala 
                645                 650                 655     


Phe His Ser Ala Leu Met Glu Pro Met Leu Glu Glu Phe Arg Ala Val 
            660                 665                 670         


Ala Ser Ser Val Glu Phe Gly Glu Pro Glu Ile Ala Leu Ser Phe Val 
        675                 680                 685             


Pro Ser Ala Asp Tyr Phe Val Arg Gln Val Arg Glu Thr Val Arg Phe 
    690                 695                 700                 


Gly Glu Gln Val Ala Ala Phe Glu Pro Gly Thr Leu Phe Val Glu Val 
705                 710                 715                 720 


Gly Pro Asp Gly Ser Leu Ser Arg Leu Thr Gly Gly Val Asn Ala Ala 
                725                 730                 735     


Glu Pro Leu Thr Ala Leu Ala His Leu Trp Ala His Gly Ala Val Val 
            740                 745                 750         


Asp Trp Thr Pro Tyr Thr Ser Asp Gly Arg Leu Asp Thr Ala Pro Thr 
        755                 760                 765             


Tyr Pro Phe Gln Pro Glu Arg Tyr Trp Pro Glu Gln Arg Arg Arg Arg 
    770                 775                 780                 


Ala Arg Arg Gly Asp Ser Leu Ala Leu Val Ile Ala Thr Ala Ala Ala 
785                 790                 795                 800 


Val Leu Gly His Pro Glu Gly Thr Asp Ile Pro Ala Asp Thr Pro Phe 
                805                 810                 815     


Gln Ser Leu Gly Phe Asp Ser Leu Ser Ala Val Asp Leu Arg Asn Gln 
            820                 825                 830         


Leu Ala His Ala Thr Gly Val Arg Leu Ser Pro Thr Ala Val Phe Asp 
        835                 840                 845             


His Pro Thr Pro Arg Ala Leu Ala Glu Arg Leu 
    850                 855                 


<210>  131
<211>  899
<212>  PRT
<213>  Actinoplanes sp.

<400>  131

Asp Pro Ile Ala Ile Val Gly Met Ala Cys Arg Tyr Pro Gly Gly Val 
1               5                   10                  15      


Ala Thr Ala Asp Asp Leu Trp Asp Leu Val Ala Glu Gly Gly Asp Ala 
            20                  25                  30          


Val Gly Pro Phe Pro Ala Asp Arg Gly Trp Asp Leu Ala Gly Leu Tyr 
        35                  40                  45              


Asp Pro Asp Pro Glu Ala Ala Gly Lys Ser Tyr Val Arg Glu Gly Gly 
    50                  55                  60                  


Phe Leu Gly Gly Ala Ala Asp Phe Asp Ala Ala Phe Phe Gly Ile Ser 
65                  70                  75                  80  


Pro Arg Glu Ala Leu Ala Met Asp Pro Gln Gln Arg Leu Leu Leu Glu 
                85                  90                  95      


Thr Ala Trp Glu Ala Phe Glu His Ala Gly Ile Asp Pro Leu Asp Leu 
            100                 105                 110         


Arg Arg Ser Asp Thr Gly Val Phe Val Gly Thr Met Ala Gln Glu Tyr 
        115                 120                 125             


Gly Gly Leu Val Thr Asp Ser Ala His Gly Leu Glu Gly Trp Ile Gly 
    130                 135                 140                 


Thr Gly Asn Ser Gln Ser Val Met Ser Gly Arg Leu Ser Tyr Phe Phe 
145                 150                 155                 160 


Gly Leu Gln Gly Pro Ala Val Thr Ile Asp Thr Ala Cys Ser Ser Ser 
                165                 170                 175     


Leu Val Ala Leu His Gln Ala Ala Gln Ala Leu Arg Ser Gly Glu Cys 
            180                 185                 190         


Ser Leu Ala Val Val Gly Gly Val Thr Val Met Ser Ser Pro Arg Thr 
        195                 200                 205             


Phe Gln Glu Phe Ser Arg Gln Arg Gly Met Ala Pro Asp Gly Arg Cys 
    210                 215                 220                 


Lys Pro Phe Ala Ala Ala Ala Asp Gly Thr Gly Trp Ser Glu Gly Val 
225                 230                 235                 240 


Gly Val Leu Val Val Glu Arg Leu Ser Glu Ala Arg Arg Asn Gly His 
                245                 250                 255     


Ala Val Leu Ala Val Val Arg Gly Thr Ala Val Asn Gln Asp Gly Thr 
            260                 265                 270         


Ser Asn Gly Leu Thr Ala Pro Asn Gly Pro Ala Gln Gln Gln Val Ile 
        275                 280                 285             


Arg Ala Ala Leu Glu Arg Ala Gly Leu Gly Val Gly Asp Val Asp Val 
    290                 295                 300                 


Val Glu Ala His Gly Thr Gly Thr Ala Leu Gly Asp Pro Ile Glu Ala 
305                 310                 315                 320 


Gln Ala Ile Leu Asp Thr Tyr Gly Ser Arg Thr Thr Gly Glu Pro Val 
                325                 330                 335     


Arg Leu Gly Ser Val Lys Ser Asn Leu Gly His Thr Gln Ala Ala Ala 
            340                 345                 350         


Gly Val Ala Gly Val Ile Lys Met Val Gln Ala Met Arg His Ala Thr 
        355                 360                 365             


Met Pro Arg Ser Leu His Ile Asp Glu Pro Ser Pro His Val Asp Trp 
    370                 375                 380                 


Ala Ser Gly Ala Val Glu Leu Leu Thr Ala Glu Arg Gly Trp Pro Ala 
385                 390                 395                 400 


Thr Asp Arg Pro Arg Arg Ala Ala Val Ser Ser Phe Gly Ile Ser Gly 
                405                 410                 415     


Thr Asn Ala His Val Ile Val Glu Gly Val Thr Glu Pro Glu Pro Ser 
            420                 425                 430         


Arg Glu Ala Ala Pro Ser Gly Pro Leu Pro Leu Met Leu Ser Ala Pro 
        435                 440                 445             


Thr Ala Glu Ala Leu Ala Glu Gln Glu Thr Arg Leu Arg Arg Phe Arg 
    450                 455                 460                 


Ala Asp Arg Pro Asp Ala Asp Glu Arg Asp Ile Ala Val Thr Leu Ala 
465                 470                 475                 480 


Gly Arg Thr Gly Phe Ala His Arg Thr Val Leu Ile Gly Glu Leu Ser 
                485                 490                 495     


Val Ser Gly Val Ala Val Ala Asp Arg Arg Val Val Phe Val Phe Pro 
            500                 505                 510         


Gly Gln Gly Thr Gln Trp Ala Gly Met Gly Arg Asp Leu Met Asp Ala 
        515                 520                 525             


Ser Pro Val Phe Ala Glu Arg Met Asn Glu Cys Ala Ala Ala Leu Glu 
    530                 535                 540                 


Pro Tyr Leu Asp Leu Trp Glu Ala Ile Asp Thr Pro Asp Arg Val Glu 
545                 550                 555                 560 


Thr Leu Gln Pro Ala Ser Trp Ala Val Met Val Ser Leu Ala Ala Val 
                565                 570                 575     


Trp Gln Ala Ala Gly Val Arg Pro Ala Ala Val Ile Gly His Ser Gln 
            580                 585                 590         


Gly Glu Ile Ala Ala Ala Cys Val Ala Gly Ser Leu Ser Leu Ala Asp 
        595                 600                 605             


Ala Ala Ala Val Val Ala Leu Arg Ser Lys Ala Ile Ala Ala Ser Leu 
    610                 615                 620                 


Gly Lys Gly Ala Met Ala Ser Ile Pro Leu Pro Ala Glu Glu Ile Glu 
625                 630                 635                 640 


Leu Ile Asp Glu Val Trp Val Ala Ala Leu Asn Gly Pro Ser Ser Thr 
                645                 650                 655     


Val Val Ala Gly Ala Pro Asp Ala Val Glu Gln Val Arg Ala Arg Tyr 
            660                 665                 670         


Asp Gly Arg Arg Ile Ala Val Asp Tyr Ala Ser His Thr Pro His Val 
        675                 680                 685             


Glu Ala Leu Arg Gly Gln Val Val Ser Val Pro Ser Gln Ala Pro Asp 
    690                 695                 700                 


Ile Pro Trp Phe Ser Thr Val Asp Ser Gly Trp Val Glu Gly Pro Leu 
705                 710                 715                 720 


Asp Asp Asp Tyr Trp Phe Arg Asn Leu Arg Gln Pro Val Gln Phe Gly 
                725                 730                 735     


Pro Ala Ala Ala Arg Phe Asp Asp Ala Val Phe Ile Glu Val Ser Ala 
            740                 745                 750         


Arg Pro Val Leu Ile Pro Val Leu Glu Asp Ala Val Thr Val Pro Thr 
        755                 760                 765             


Leu Arg Arg Asp Asp Gly Gly Ile Gly Arg Leu His Ala Ser Val Ala 
    770                 775                 780                 


Gln Ala Trp Thr Ala Gly Ala Asp Val Asp Trp Ala Ala Leu Leu Pro 
785                 790                 795                 800 


Ala Gly Gly Arg Arg Ile Ala Leu Pro Pro Tyr Ala Phe Thr His Glu 
                805                 810                 815     


Arg Phe Trp Pro Arg Arg Pro Ala Ala Ala Gly Gln Asp Leu Leu Thr 
            820                 825                 830         


Val Val Arg Thr Ala Ala Ala Thr Val Leu Gly His Arg Asp Ala Ala 
        835                 840                 845             


Arg Val Pro Ala Asp Arg Ala Phe Lys Glu Leu Gly Phe Asp Ser Leu 
    850                 855                 860                 


Ser Ala Val Gln Leu Arg Asn Glu Leu Leu Thr Ala Thr Gly Val Arg 
865                 870                 875                 880 


Leu Ser Ala Thr Ala Val Phe Asp His Pro Thr Ala Ala Ala Leu Ala 
                885                 890                 895     


Glu Ala Leu 
            


<210>  132
<211>  873
<212>  PRT
<213>  Actinoplanes sp.

<400>  132

Glu Pro Ile Ala Ile Val Gly Met Ala Cys Arg Leu Pro Gly Asp Val 
1               5                   10                  15      


Ser Ser Pro Asp Glu Leu Trp Glu Leu Val Glu Ser Gly Arg Asp Ala 
            20                  25                  30          


Ile Gly Pro Phe Pro Ala Asp Arg Gly Trp Asn Leu Ser Thr Leu Phe 
        35                  40                  45              


Asp Pro Asp Pro Asp Ala Pro Gly Lys Ser Tyr Val Arg Glu Gly Gly 
    50                  55                  60                  


Phe Leu Thr Gly Ala Gly Leu Phe Asp Ala Asp Phe Phe Gly Ile Ser 
65                  70                  75                  80  


Pro Arg Glu Ala Leu Ala Met Asp Pro Gln Gln Arg Leu Leu Leu Glu 
                85                  90                  95      


Val Ala Trp Glu Ala Phe Glu Arg Ala Gly Ile Ala Pro Asp Ala Leu 
            100                 105                 110         


Arg Gly Ser Asp Thr Gly Val Tyr Val Gly Thr Tyr Ala Gln Gly Tyr 
        115                 120                 125             


Gly Glu Leu Ala Ala Ala Thr Ala Gly Glu Gly Phe Val Gly Ile Gly 
    130                 135                 140                 


Asn Ser Gly Ser Val Val Ser Gly Arg Val Ser Tyr Phe Leu Gly Leu 
145                 150                 155                 160 


Glu Gly Pro Ala Val Thr Val Asp Thr Ala Cys Ser Ser Ser Leu Val 
                165                 170                 175     


Ala Leu His Gln Ala Ala Gln Ala Leu Arg Leu Gly Glu Cys Ser Leu 
            180                 185                 190         


Ala Leu Val Gly Gly Val Thr Val Met Ala Ser Pro Leu Met Phe Gln 
        195                 200                 205             


Glu Phe Ser Arg Gln Arg Gly Leu Ser Pro Asp Gly Arg Cys Lys Ala 
    210                 215                 220                 


Phe Ala Glu Gly Ala Asp Gly Thr Gly Trp Gly Glu Gly Ala Gly Val 
225                 230                 235                 240 


Leu Val Val Glu Arg Leu Ser Glu Ala Arg Arg Arg Gly His Thr Val 
                245                 250                 255     


Leu Ala Val Val Arg Gly Ser Ala Val Asn Gln Asp Gly Ala Ser Asn 
            260                 265                 270         


Gly Leu Thr Ala Pro Asn Gly Pro Ser Gln Gln Arg Val Ile Arg Ala 
        275                 280                 285             


Ala Leu Ala Ala Ala Gly Leu Thr Phe Gly Asp Val Asp Val Val Glu 
    290                 295                 300                 


Gly His Gly Thr Gly Thr Ala Leu Gly Asp Pro Ile Glu Ala Gln Ala 
305                 310                 315                 320 


Leu Leu Ala Thr Tyr Gly Ala Ala Gly Ser Pro Val Arg Leu Gly Ser 
                325                 330                 335     


Leu Lys Ser Asn Ile Gly His Thr Gln Ala Ala Ala Gly Val Ala Gly 
            340                 345                 350         


Val Ile Lys Met Val Gln Ala Met Arg His Gly Val Met Pro Arg Thr 
        355                 360                 365             


Leu His Val Asp Gln Pro Ser Ser His Val Asp Trp Ser Ala Gly Ala 
    370                 375                 380                 


Val Glu Leu Leu Thr Ala Asn Arg Thr Trp Glu Ala Pro Gly Arg Pro 
385                 390                 395                 400 


Arg Arg Ala Ala Val Ser Ser Phe Gly Ile Ser Gly Thr Asn Ala His 
                405                 410                 415     


Val Ile Leu Glu Gly Val Pro Ala Pro Glu Pro Ala Ala Gly Ser Ala 
            420                 425                 430         


Glu Thr Ala Pro Leu Leu Leu Ser Ala Arg Thr Val Pro Ala Leu Asn 
        435                 440                 445             


Asp Phe Glu Ala Arg Val Ser Ala Arg Pro Ser Ser Pro Asp Leu Ala 
    450                 455                 460                 


Ala Thr Leu Ser Arg Arg Val Phe Phe Asp His Arg Ala Val Val Leu 
465                 470                 475                 480 


Pro Gly Gly Glu Val Val Arg Gly Arg Val Gly Asp Ala Pro Val Val 
                485                 490                 495     


Phe Val Phe Ala Gly Gln Gly Ser Gln Arg Ala Asp Met Ala Ser Arg 
            500                 505                 510         


Leu Ala Gly Glu Phe Pro Val Phe Ala Ala Ala His Glu Arg Val Trp 
        515                 520                 525             


Ser Leu Leu Asp Val Asp Glu Gly Leu Ala Val Asp Gln Thr Gly Leu 
    530                 535                 540                 


Ala Gln Pro Ala Leu Phe Ala Tyr Glu Val Ala Leu Ala Glu Leu Leu 
545                 550                 555                 560 


Gly Val Arg Pro Asp Ala Val Ile Gly His Ser Val Gly Glu Leu Ala 
                565                 570                 575     


Ala Ala Tyr Val Ala Gly Ala Leu Ser Leu Glu Asp Ala Cys Arg Leu 
            580                 585                 590         


Val Ser Ala Arg Ala Arg Leu Met Gln Ala Leu Pro Pro Gly Gly Val 
        595                 600                 605             


Met Val Ser Val Arg Val Ser Glu Glu Ala Ala Arg Ala Val Leu Arg 
    610                 615                 620                 


Asp Gly Val Glu Ile Ala Ala Val Asn Gly Pro Arg Ala Val Val Leu 
625                 630                 635                 640 


Ser Gly Asp Glu Asp Ala Val Leu Ala Ala Ala Ala Glu Leu Gly Glu 
                645                 650                 655     


Phe Arg Arg Leu Arg Thr Ser His Ala Phe His Ser Ala Arg Met Glu 
            660                 665                 670         


Pro Met Leu Glu Glu Phe Arg Ala Val Ala Ser Ser Val Val Phe Gly 
        675                 680                 685             


Glu Pro Glu Ile Ala Met Ser Phe Val Pro Ser Ala Asp Tyr Phe Val 
    690                 695                 700                 


Arg Gln Val Arg Glu Thr Val Arg Phe Gly Glu Gln Val Ala Ser Phe 
705                 710                 715                 720 


Asp Pro Gly Ser Leu Phe Val Glu Val Gly Pro Asp Gly Ser Leu Ser 
                725                 730                 735     


Arg Leu Thr Gly Gly Val Ser Ala Ala Glu Pro Met Lys Ala Leu Ala 
            740                 745                 750         


Tyr Leu Trp Val Arg Gly Val Gly Val Asp Trp Ala Pro Tyr Val Gly 
        755                 760                 765             


Gly Gly Arg Leu Asp Leu Gly Ala Pro Thr Tyr Pro Phe Gln Arg Glu 
    770                 775                 780                 


Gly Phe Trp Pro Thr Arg Glu Ala Leu Ala Gln Leu Pro Pro Ala Arg 
785                 790                 795                 800 


Arg Gly Arg Ala Leu Leu Asp Leu Val Gln Asn Arg Val Ala Lys Thr 
                805                 810                 815     


Leu Gly Leu Val Arg Pro Ala Asp Pro Gly Arg Ala Phe Thr Asp Leu 
            820                 825                 830         


Gly Phe Thr Ser Leu Thr Ala Leu Glu Leu Arg Asn Ser Ile Ala Glu 
        835                 840                 845             


Glu Thr Gly Leu Pro Leu Pro Ala Ser Leu Val Phe Asp His Pro Asn 
    850                 855                 860                 


Ala Arg Ala Leu Ala Ala Tyr Leu Asp 
865                 870             


<210>  133
<211>  898
<212>  PRT
<213>  Actinoplanes sp.

<400>  133

Glu Pro Leu Ala Ile Val Gly Met Ala Cys Arg Leu Pro Gly Gly Ile 
1               5                   10                  15      


Ser Ser Ala Glu Glu Leu Trp Arg Leu Val Ala Glu Gly Gly Asp Ala 
            20                  25                  30          


Ile Gly Pro Phe Pro Gly Asp Arg Gly Trp Asp Ile Asp Ala Leu Tyr 
        35                  40                  45              


Asp Pro Asp Pro Asp Ala Ala Gly Arg Thr Tyr Thr Arg Ser Gly Gly 
    50                  55                  60                  


Phe Leu Pro Gly Ala Gly Asp Phe Asp Ala Ala Phe Phe Gly Ile Ser 
65                  70                  75                  80  


Pro Arg Glu Ala Gln Ala Met Asp Pro Gln His Arg Gln Leu Leu Glu 
                85                  90                  95      


Thr Ser Trp Glu Ala Leu Glu His Ala Gly Ile Asp Pro Ala Gly Leu 
            100                 105                 110         


Arg Gly Arg Asp Val Gly Val Phe Ala Gly Phe Ser Gly Gln Asp Tyr 
        115                 120                 125             


Ile Ala Glu Met Gly Val Gly Pro Ala Glu Ala Gly Gly Tyr Gln Val 
    130                 135                 140                 


Thr Gly Arg Ala Ala Ser Val Leu Ser Gly Arg Leu Ser Tyr Phe Tyr 
145                 150                 155                 160 


Gly Phe Glu Gly Pro Ala Val Thr Val Asp Thr Ala Cys Ser Ser Ser 
                165                 170                 175     


Leu Val Ala Leu His Leu Ala Gly Gln Ser Leu Arg Asp Gly Glu Ser 
            180                 185                 190         


Ser Leu Ala Leu Val Gly Gly Val Thr Val Met Ser Ser Pro Gly Leu 
        195                 200                 205             


Phe Val Glu Phe Ser Arg Gln Arg Gly Leu Ala Pro Asp Gly Arg Cys 
    210                 215                 220                 


Lys Ala Phe Ser Val Asp Ala Asp Gly Thr Gly Trp Ser Glu Gly Val 
225                 230                 235                 240 


Gly Val Leu Val Val Glu Arg Leu Ser Asp Ala Arg Arg Asn Asn His 
                245                 250                 255     


Gln Ile Leu Ala Val Val Arg Gly Ser Ala Val Asn Gln Asp Gly Ala 
            260                 265                 270         


Ser Asn Gly Leu Thr Ala Pro Asn Gly Pro Ser Gln Gln Arg Val Ile 
        275                 280                 285             


Arg Gln Ala Leu Ala Gln Ser Gly Leu Ser Val Gly Asp Val Asp Val 
    290                 295                 300                 


Val Glu Ala His Gly Thr Gly Thr Ala Leu Gly Asp Pro Ile Glu Ala 
305                 310                 315                 320 


Gln Ala Val Leu Ala Thr Tyr Gly Ser Arg Thr Gly Gly Glu Pro Val 
                325                 330                 335     


Arg Leu Gly Ser Leu Lys Ser Asn Ile Gly His Thr Gln Ala Ala Ala 
            340                 345                 350         


Gly Ile Ala Ser Leu Ile Lys Met Val Gln Ser Ile Arg Tyr Gly Val 
        355                 360                 365             


Met Pro Arg Thr Leu His Val Ser Glu Pro Ser Pro Leu Val Asp Trp 
    370                 375                 380                 


Ala Ala Gly Arg Val Glu Leu Leu Thr Ser Asp Val Pro Trp Pro Glu 
385                 390                 395                 400 


Gly Val Arg Arg Ala Ala Val Ser Ala Phe Gly Ile Ser Gly Thr Asn 
                405                 410                 415     


Ala His Val Ile Leu Glu Glu Ala Pro Ala Pro Ala Glu Ala Val Pro 
            420                 425                 430         


Ser Ile Arg Pro Val Val Ser Gly Pro Glu Leu Pro Leu Val Phe Ser 
        435                 440                 445             


Ala Arg Asp Ala Asp Ala Leu Ala Ala Gln Ser Arg Leu Thr Asp Gly 
    450                 455                 460                 


Pro Gly Val Ala His Ala Leu Val Thr Ala Arg Thr Val Phe Asp His 
465                 470                 475                 480 


Arg Ser Val Arg Met Gly Asp Val Thr Val Thr Gly Val Ala Thr Pro 
                485                 490                 495     


Asp Pro Glu Val Val Phe Val Phe Pro Gly Gln Gly Thr Gln Trp Pro 
            500                 505                 510         


Gly Met Gly Arg Asp Leu Met Ala Ala Ser Pro Val Phe Ala Asp Arg 
        515                 520                 525             


Met Asn Glu Cys Ala Leu Ala Leu Ser Pro Tyr Leu Asp Leu Trp Ala 
    530                 535                 540                 


Ala Ile Asp Ala Pro Asp Arg Val Glu Thr Leu Gln Pro Ala Ser Trp 
545                 550                 555                 560 


Ala Val Met Val Ser Leu Ala Ala Val Trp Gln Ala Ala Gly Val Gln 
                565                 570                 575     


Pro Ala Ala Val Ile Gly His Ser Gln Gly Glu Ile Ala Ala Ala Cys 
            580                 585                 590         


Val Ala Gly Ser Leu Ser Leu Ala Asp Ala Ala Ala Val Val Ala Leu 
        595                 600                 605             


Arg Ser Arg Ala Ile Ala Ser Leu Ala Gly Lys Gly Ala Met Ala Ser 
    610                 615                 620                 


Ile Pro Leu Pro Ala Glu Glu Ile Glu Leu Val Asp Glu Val Trp Val 
625                 630                 635                 640 


Ala Ala Leu Asn Gly Pro Ser Ser Thr Val Val Ala Gly Thr Pro Asp 
                645                 650                 655     


Ala Val Glu Gln Ile Arg Ser Arg Tyr Asp Gly Arg Arg Ile Ala Val 
            660                 665                 670         


Asp Tyr Ala Ser His Thr Pro His Val Glu Ala Leu Arg Gly Gln Val 
        675                 680                 685             


Val Ser Val Pro Ser Gln Ser Pro Ala Val Pro Trp Phe Ser Thr Val 
    690                 695                 700                 


Asp Ser Ala Trp Val Glu Gly Pro Leu Asp Glu Asp Tyr Trp Phe Arg 
705                 710                 715                 720 


Asn Leu Arg Gln Pro Val Gln Phe Gly Pro Ala Ala Ala Gly Phe Asp 
                725                 730                 735     


Asn Ala Val Phe Val Glu Val Ser Ala Arg Pro Val Leu Ile Pro Ala 
            740                 745                 750         


Leu Asp Ala Ser Val Thr Val Pro Ser Leu Arg Arg Asp Asp Gly Gly 
        755                 760                 765             


Pro Glu Arg Met Leu Ala Ser Leu Ala Gln Ala Phe Val Ala Gly Val 
    770                 775                 780                 


Ala Val Asp Trp Thr Thr Ile Val Pro Pro Ala Pro His Val Asp Leu 
785                 790                 795                 800 


Pro Thr Tyr Pro Phe Arg Arg Gln Arg His Trp Ile Asp Met Glu Arg 
                805                 810                 815     


Leu Gly Gln Leu Pro Pro Gly Asp Arg Asp Arg Phe Leu Leu Asp Leu 
            820                 825                 830         


Val Arg Asp Ala Ala Ala Ala Val Leu Gly His Gly Ser Arg Glu Thr 
        835                 840                 845             


Val Pro Ala Ser Ala Ala Phe Lys Glu Leu Gly Phe Asp Ser Leu Ile 
    850                 855                 860                 


Ala Val Gln Leu Arg Asn Ala Val Ala Ala Ala Thr Gly Val Ser Leu 
865                 870                 875                 880 


Pro Ala Thr Val Thr Phe Asp His Pro Thr Pro Gln Ala Leu Ala Val 
                885                 890                 895     


Leu Leu 
        


<210>  134
<211>  920
<212>  PRT
<213>  Actinoplanes sp.

<400>  134

Glu Pro Leu Ala Ile Val Gly Met Ala Cys Lys Phe Pro Gly Gly Val 
1               5                   10                  15      


Asp Ser Pro Glu Arg Leu Trp Glu Met Val Glu Ala Gly Glu Asp Val 
            20                  25                  30          


Ile Gly Pro Phe Pro Asp Asp Arg Gly Trp Asp Val Asp Gly Gly Tyr 
        35                  40                  45              


Asp Pro Asp Pro Glu Lys Ala Gly Ser Trp Tyr Ala Arg Ala Gly Gly 
    50                  55                  60                  


Phe Leu Ala Gly Ala Ala Asp Phe Asp Ala Ala Phe Phe Gly Ile Asn 
65                  70                  75                  80  


Pro Arg Glu Ala Leu Ala Met Asp Pro Gln Gln Arg Leu Leu Leu Glu 
                85                  90                  95      


Val Ala Trp Glu Ala Phe Glu Arg Ser Gly Ile Ala Pro Asp Ser Leu 
            100                 105                 110         


Arg Gly Thr Asp Thr Gly Val Phe Val Gly Thr Phe Gly Gln Gly Tyr 
        115                 120                 125             


Gly Arg Leu Val Ala Ala Gly Ala Pro Gly Leu Glu Ala Tyr Ser Gly 
    130                 135                 140                 


Thr Gly Asn Thr Gly Ser Val Ala Ser Gly Arg Leu Ser Tyr Val Phe 
145                 150                 155                 160 


Gly Leu Glu Gly Pro Ala Val Thr Val Asp Thr Ala Cys Ser Ser Ser 
                165                 170                 175     


Leu Val Ala Leu His Gln Ala Gly Arg Ser Leu Gln Ser Gly Glu Cys 
            180                 185                 190         


Ser Leu Ala Leu Val Ala Gly Val Thr Val Met Ser Thr Pro Asp Ser 
        195                 200                 205             


Phe Val Glu Phe Ser Arg Gln Arg Gly Leu Ser Pro Asp Gly Arg Cys 
    210                 215                 220                 


Lys Ala Phe Ala Ala Ala Ala Asp Gly Thr Gly Phe Ser Glu Gly Ala 
225                 230                 235                 240 


Gly Val Leu Val Val Glu Arg Leu Ser Asp Ala Arg Arg Asn Asn His 
                245                 250                 255     


Gln Ile Leu Ala Leu Val Arg Gly Ser Ala Val Asn Gln Asp Gly Ala 
            260                 265                 270         


Ser Asn Gly Leu Thr Ala Pro Asn Gly Pro Ser Gln Gln Arg Val Ile 
        275                 280                 285             


Thr Ala Ala Leu Thr Asp Ala Arg Leu Thr Thr Thr Asp Ile Asp Leu 
    290                 295                 300                 


Val Glu Ala His Gly Thr Gly Thr Thr Leu Gly Asp Pro Ile Glu Ala 
305                 310                 315                 320 


Gln Ala Ile Leu Ala Thr Tyr Gly Asn Arg Thr Thr Gly Asn Pro Val 
                325                 330                 335     


His Leu Gly Ser Val Lys Ser Asn Leu Gly His Thr Gln Ala Ala Ala 
            340                 345                 350         


Gly Ile Ala Gly Val Ile Lys Ala Ile Gln Ala Ile Arg His Thr Thr 
        355                 360                 365             


Met Pro Lys Ser Leu His Ile Asp Gln Pro Ser Pro His Val Asp Trp 
    370                 375                 380                 


Thr Ser Gly Arg Val Glu Leu Leu Thr Ser Asn Gln Pro Trp Pro Ala 
385                 390                 395                 400 


Thr Asp Arg Pro Arg Arg Ala Ala Val Ser Ser Phe Gly Val Ser Gly 
                405                 410                 415     


Thr Asn Ala His Val Ile Leu Glu Glu Gln Thr Pro Val Glu Glu Pro 
            420                 425                 430         


Pro Pro Ala Ser Ala Gly Pro Val Pro Leu Ala Leu Ser Ala Arg Thr 
        435                 440                 445             


Pro Glu Ala Leu Thr Ala Gln Glu Lys Ala Val Arg Gly Leu Pro Asp 
    450                 455                 460                 


Gly Asp Arg Arg Arg Ala Ala Pro Ala Leu Ala Leu Gly Arg Ala Ala 
465                 470                 475                 480 


Leu Pro His Arg Ala Val Leu Leu Gly Asp Ser Val Ile Arg Gly Thr 
                485                 490                 495     


Ala Ser Ala Asp Asp Gly Arg Pro Val Phe Leu Phe Pro Gly Gln Gly 
            500                 505                 510         


Ala Gln Trp Ala Gly Met Gly Arg Glu Leu Met Ala Ala Ser Pro Val 
        515                 520                 525             


Phe Ala Glu Arg Met Arg Glu Cys Ala Val Ala Leu Ala Gly Phe Val 
    530                 535                 540                 


Asp Trp Asp Leu Phe Ala Val Leu Asp Asp Ala Glu Ala Leu Arg Arg 
545                 550                 555                 560 


Thr Glu Ile Val Gln Pro Ala Ser Trp Ala Met Met Val Ser Leu Ala 
                565                 570                 575     


Ala Leu Trp Glu Ser Trp Gly Val Arg Pro Ala Ala Val Val Gly His 
            580                 585                 590         


Ser Gln Gly Glu Thr Ala Ala Ala Val Val Ala Gly Ala Ile Gly Leu 
        595                 600                 605             


Arg Asp Gly Ala Arg Leu Ser Ala Thr Arg Ser Arg Val Leu Ala Leu 
    610                 615                 620                 


Leu Ala Gly His Gly Ala Leu Ala Ser Ile Ala Leu Pro Ala Gly Glu 
625                 630                 635                 640 


Val Glu Val Val Asp Gly Val Ser Val Ala Ala Val Asn Gly Pro Arg 
                645                 650                 655     


Ala Thr Leu Ile Ser Gly Asp Pro Ala Gly Val Glu Ala Val Thr Ala 
            660                 665                 670         


Arg Tyr Glu Ala Ser Gly Val Arg Val Arg Arg Ile Pro Ala Asp Val 
        675                 680                 685             


Ala Ser His Ser Pro His Val Glu Arg Ala Glu Glu Thr Leu Leu Ala 
    690                 695                 700                 


Ala Leu Ala Gly Ile Glu Ala Arg Val Pro Gly Val Pro Trp Leu Ser 
705                 710                 715                 720 


Thr Ala Thr Gly Asp Trp Ile Thr Glu Pro Val Asp Glu Arg Tyr Trp 
                725                 730                 735     


Tyr Arg Asn Leu Arg Ser Pro Val Leu Phe His Pro Ala Ile Thr Thr 
            740                 745                 750         


Leu Arg Asp Arg Gly His Arg Leu Phe Leu Glu Ile Ser Thr His Pro 
        755                 760                 765             


Gln Leu Leu Pro Ala Met Glu Asp Asp Leu Leu Thr Val Gly Ser Leu 
    770                 775                 780                 


Arg Arg Asp Asp Gly Asp Leu Asp Arg Met His Ala Ala Leu Ala Glu 
785                 790                 795                 800 


Ala Trp Ala Ala Gly Ala Asp Val Asp Trp Arg Ala Phe Leu Gly Ser 
                805                 810                 815     


Gly Pro Val Arg Ala Leu Asp Leu Pro Thr Tyr Pro Phe Gln Arg Arg 
            820                 825                 830         


Arg Phe Trp Pro Glu Ala Gly Ala Leu Pro Pro Ala Glu Arg Glu Arg 
        835                 840                 845             


Ala Leu Val Glu Ile Val Arg Asp Gln Ala Ala Ala Val Leu Gly Asp 
    850                 855                 860                 


Pro Asp Ala Gly Ala Leu Thr Pro Gly Thr Ala Phe Arg Asp Leu Gly 
865                 870                 875                 880 


Phe Asp Ser Leu Thr Ala Val Gln Leu Arg Asn His Leu Ala Thr Ala 
                885                 890                 895     


Thr Gly Leu Thr Leu Pro Ala Thr Val Ile Phe Asp His Pro Thr Pro 
            900                 905                 910         


Arg Ala Leu Ala Thr Phe Leu Asp 
        915                 920 


<210>  135
<211>  883
<212>  PRT
<213>  Actinoplanes sp.

<400>  135

Glu Pro Leu Ala Val Val Gly Met Ala Cys Arg Leu Pro Gly Gly Val 
1               5                   10                  15      


Ser Ser Pro Asp Gln Leu Trp Asp Leu Val Val Ser Gly Gly Asp Gly 
            20                  25                  30          


Ile Gly Pro Phe Pro Gly Asp Arg Gly Trp Ala Thr Asp Glu Ile Tyr 
        35                  40                  45              


Asp Pro Asp Pro Asp Ala Ser Gly Lys Thr Tyr Val Arg Glu Gly Gly 
    50                  55                  60                  


Phe Leu Asp Ser Ala Gly Asp Phe Asp Ala Ala Phe Phe Gly Ile Ser 
65                  70                  75                  80  


Pro Arg Glu Ala Leu Ala Met Asp Pro Gln Gln Arg Leu Leu Leu Glu 
                85                  90                  95      


Thr Ser Trp Glu Ala Phe Glu His Ala Gly Ile Asp Pro Ala Gly Leu 
            100                 105                 110         


Arg Gly Gly Asp Thr Gly Val Phe Val Gly Gly Phe Thr Gln Ala Tyr 
        115                 120                 125             


Gly Val Gly Thr Ala Asp Leu Glu Gly Tyr Ala Ala Thr Gly Thr Val 
    130                 135                 140                 


Gly Ser Val Leu Ser Gly Arg Leu Ser Tyr Phe Tyr Gly Phe Glu Gly 
145                 150                 155                 160 


Pro Ala Val Thr Ile Asp Thr Ala Cys Ser Ser Ser Leu Val Ala Leu 
                165                 170                 175     


His Gln Ala Gly Gln Ala Leu Arg Gln Gly Glu Cys Thr Leu Ala Val 
            180                 185                 190         


Val Gly Gly Val Thr Val Met Pro Thr Pro Val Val Phe Gln Glu Phe 
        195                 200                 205             


Ser Arg Gln Arg Gly Leu Ala Ala Asp Gly Arg Cys Lys Ala Phe Ala 
    210                 215                 220                 


Asp Glu Ala Asp Gly Thr Gly Phe Ala Glu Gly Ala Gly Val Leu Leu 
225                 230                 235                 240 


Val Cys Arg Leu Ser Asp Ala Arg Arg Asp Gly Arg Arg Ile Leu Ala 
                245                 250                 255     


Val Val Arg Gly Ser Ala Val Asn Gln Asp Gly Ala Ser Asn Gly Leu 
            260                 265                 270         


Thr Ala Pro Asn Gly Pro Ser Gln Gln Arg Val Ile Arg Ala Ala Leu 
        275                 280                 285             


Ala Ser Ala Arg Leu Gly Pro Gly Asp Val Asp Leu Ile Glu Gly His 
    290                 295                 300                 


Gly Thr Gly Thr Thr Leu Gly Asp Pro Ile Glu Ala Gln Ala Leu Leu 
305                 310                 315                 320 


Ala Thr His Gly Ser Gly Ala Ser Pro Val Arg Leu Gly Ser Leu Lys 
                325                 330                 335     


Ser Asn Ile Gly His Thr Gln Ala Ala Ala Gly Val Ala Gly Val Ile 
            340                 345                 350         


Lys Val Ile Gln Ala Leu Arg His Gly Leu Met Pro Arg Thr Leu His 
        355                 360                 365             


Val Gly Thr Pro Ser Ser Gln Val Asp Trp Ser Ala Gly Asn Val Glu 
    370                 375                 380                 


Leu Leu Thr Ser Asn Leu Pro Trp Pro Ala Thr Asp Arg Pro Arg Arg 
385                 390                 395                 400 


Ala Ala Val Ser Ser Phe Gly Ile Ser Gly Thr Asn Ala His Val Ile 
                405                 410                 415     


Leu Glu Glu Ala Pro Ala Pro Ala Ala Val Pro Ser Ile Thr Pro Val 
            420                 425                 430         


Val Ser Gly Pro Ala Leu Pro Leu Val Phe Ser Ala Arg Asp Ser Gly 
        435                 440                 445             


Ala Leu Ala Ala Arg Thr Arg Leu Thr Asp Gly Pro Gly Val Ala Phe 
    450                 455                 460                 


Ala Leu Ala Thr Ser Arg Ser Met Phe Asp His Arg Ala Val Arg Ile 
465                 470                 475                 480 


Gly Asp Leu Ser Val Ser Gly Val Ala Val Ala Asp Arg Arg Val Val 
                485                 490                 495     


Phe Val Phe Pro Gly Gln Gly Thr Gln Trp Ala Gly Met Gly Arg Ala 
            500                 505                 510         


Leu Met Asp Ala Ser Pro Val Phe Ala Glu Arg Met Asn Glu Cys Ala 
        515                 520                 525             


Ala Ala Leu Ser Pro Tyr Leu Asp Leu Trp Glu Ala Ile Asp Ala Pro 
    530                 535                 540                 


Asp Arg Val Glu Thr Leu Gln Pro Ala Ser Trp Ala Val Met Val Ser 
545                 550                 555                 560 


Leu Ala Ala Val Trp Gln Ala Val Gly Val Glu Pro Ala Ala Val Ile 
                565                 570                 575     


Gly His Ser Gln Gly Glu Ile Ala Ala Ala Cys Val Ala Gly Ser Ile 
            580                 585                 590         


Ser Leu Pro Asp Ala Ala Ala Val Val Ala Leu Arg Ser Lys Ala Ile 
        595                 600                 605             


Ala Ser Leu Ala Gly Lys Gly Ala Met Ala Ser Ile Pro Leu Pro Pro 
    610                 615                 620                 


Asp Gln Ile Asp Leu Ile Asp Gln Val Trp Ile Ala Ala Leu Asn Gly 
625                 630                 635                 640 


Pro Ser Ser Thr Val Val Ala Gly Ser Pro Glu Ala Val Glu Gln Val 
                645                 650                 655     


Arg Ala Arg Tyr Asp Gly Arg Arg Ile Ala Val Asp Tyr Ala Ser His 
            660                 665                 670         


Thr Pro His Val Glu Ala Leu Arg Gly Gln Val Val Ser Val Pro Ser 
        675                 680                 685             


Gln Ala Pro Asp Ile Pro Trp Phe Ser Thr Val Asp Ser Ala Trp Val 
    690                 695                 700                 


Glu Lys Pro Leu Asp Gly Asp Tyr Trp Phe Arg Asn Leu Arg Gln Pro 
705                 710                 715                 720 


Val Gln Phe Gly Pro Ala Ala Ala Arg Phe Asp Asp Ala Val Phe Ile 
                725                 730                 735     


Glu Val Ser Ala Arg Pro Val Leu Ile Pro Ala Leu Asp Thr Ser Val 
            740                 745                 750         


Thr Val Pro Ser Leu Arg Arg Asp Asp Gly Gly Pro Glu Arg Met Leu 
        755                 760                 765             


Ala Ser Leu Ala Gln Ala Phe Val Ala Gly Val Ala Val Asp Trp Thr 
    770                 775                 780                 


Thr Ile Val Pro Pro Ala Pro Phe Val Glu Leu Pro Thr Tyr Pro Phe 
785                 790                 795                 800 


Gln Arg Arg Arg Tyr Trp Ile Asp Ser Ser Glu Glu Ala Leu Arg Asp 
                805                 810                 815     


Leu Val Arg Glu Gln Ala Ala Ala Val Leu Gly Tyr Pro Asp Pro Ser 
            820                 825                 830         


Arg Ile Thr Pro Gly Val Ala Phe Arg Asp Leu Gly Phe Asp Ser Leu 
        835                 840                 845             


Thr Ala Val Gln Leu Arg Asn Ala Leu Ser Ala Ala Thr Gly Leu Arg 
    850                 855                 860                 


Leu Ser Ala Thr Val Ala Phe Asp His Pro Thr Pro Ala Ala Leu Ala 
865                 870                 875                 880 


Ala Ala Leu 
            


<210>  136
<211>  872
<212>  PRT
<213>  Actinoplanes sp.

<400>  136

Glu Pro Ile Ala Ile Val Gly Met Ala Cys Arg Leu Pro Gly Asp Val 
1               5                   10                  15      


Ser Ser Pro Asp Glu Leu Trp Asp Leu Val Glu Ser Gly Arg Asp Ala 
            20                  25                  30          


Ile Gly Pro Phe Pro Ala Asp Arg Gly Trp Asn Leu Asp Glu Leu Tyr 
        35                  40                  45              


Asp Pro Asp Pro Asp Ala Thr Gly Arg Ser Tyr Val Arg Glu Gly Gly 
    50                  55                  60                  


Phe Leu Ala Gly Ala Ala Asp Phe Asp Ala Glu Phe Phe Gly Ile Asn 
65                  70                  75                  80  


Pro Arg Glu Ala Leu Ala Met Asp Pro Gln Gln Arg Leu Val Leu Glu 
                85                  90                  95      


Val Ala Trp Glu Ala Phe Glu Arg Ala Gly Ile Ala Pro Asp Ser Leu 
            100                 105                 110         


Arg Gly Thr Asp Thr Gly Val Phe Leu Gly Ala Phe Ala Gly Gly Tyr 
        115                 120                 125             


Leu Thr Leu Val Asn Gly Ala Ala Asp Leu Glu Gly Tyr Ala Gly Thr 
    130                 135                 140                 


Gly Asn Ser Val Ser Val Leu Ser Gly Arg Leu Ser Tyr Val Leu Gly 
145                 150                 155                 160 


Leu Glu Gly Pro Ala Val Thr Val Asp Thr Ala Cys Ser Ser Ser Leu 
                165                 170                 175     


Val Ala Leu His Gln Ala Ala Gln Ala Leu Arg Gln Gly Glu Cys Ser 
            180                 185                 190         


Leu Ala Val Ala Gly Gly Val Thr Val Met Ser Thr Pro Asp Ser His 
        195                 200                 205             


Val Glu Phe Ser Arg Gln Arg Ala Leu Ser Pro Asp Gly Arg Cys Arg 
    210                 215                 220                 


Ala Phe Ala Asp Gly Ala Asp Gly Thr Gly Trp Ser Glu Gly Ala Gly 
225                 230                 235                 240 


Val Leu Val Val Glu Arg Leu Ser Glu Ala Arg Arg Arg Gly His Thr 
                245                 250                 255     


Val Leu Ala Val Val Arg Gly Ser Ala Val Asn Gln Asp Gly Ala Ser 
            260                 265                 270         


Asn Gly Leu Thr Ala Pro Asn Gly Pro Ser Gln Gln Arg Val Ile Arg 
        275                 280                 285             


Ser Ala Leu Ala Ser Ala Gly Leu Gly Phe Gly Asp Val Asp Leu Val 
    290                 295                 300                 


Glu Gly His Gly Thr Gly Thr Ala Leu Gly Asp Pro Ile Glu Ala Gln 
305                 310                 315                 320 


Ala Leu Leu Ala Thr Tyr Gly Ser Ala Gly Thr Pro Val Trp Leu Gly 
                325                 330                 335     


Ser Leu Lys Ser Asn Ile Gly His Thr Gln Ala Ala Ala Gly Val Ala 
            340                 345                 350         


Gly Val Ile Lys Ala Val Glu Ala Met Arg Arg Gly Val Met Pro Arg 
        355                 360                 365             


Thr Leu His Val Asp Ala Pro Ser Ser His Val Glu Trp Ser Ser Gly 
    370                 375                 380                 


Ser Val Glu Leu Leu Thr Ala Asn Arg Pro Trp Asp Gly Val Gly Arg 
385                 390                 395                 400 


Pro Arg Arg Ala Ala Val Ser Ser Phe Gly Ile Ser Gly Thr Asn Ala 
                405                 410                 415     


His Val Ile Leu Glu Gly Val Pro Ala Pro Glu Pro Ala Gly Thr Gly 
            420                 425                 430         


Gln Ala Pro Leu Leu Leu Ser Ala Arg Ser Val Ser Ala Leu Ala Glu 
        435                 440                 445             


Phe Glu Ser Arg Ile Ala Gly Leu Val Pro Ser Arg Asp Leu Ala Ala 
    450                 455                 460                 


Thr Leu Ala Gly Arg Ala Phe Phe Asp His Arg Ala Val Ile Leu Pro 
465                 470                 475                 480 


Asp Gly Asp Val Val Arg Gly Arg Ala Gly Gly Ala Pro Leu Val Phe 
                485                 490                 495     


Val Phe Ala Gly Gln Gly Ser Gln Arg Ala Asp Met Ala Ser Arg Leu 
            500                 505                 510         


Ala Glu Glu Phe Pro Ala Phe Ala Ala Ala His Glu Arg Val Trp Ser 
        515                 520                 525             


Leu Leu Asp Val Asp Glu Gly Leu Asp Val Asp Gln Thr Gly Leu Ala 
    530                 535                 540                 


Gln Pro Ala Leu Phe Ala Tyr Glu Val Ala Leu Ala Glu Leu Leu Gly 
545                 550                 555                 560 


Val Arg Pro Asp Ala Val Ile Gly His Ser Ile Gly Glu Leu Ala Ala 
                565                 570                 575     


Ala Tyr Val Ala Gly Ala Leu Ser Leu Glu Asp Ala Cys Arg Leu Val 
            580                 585                 590         


Ser Ala Arg Ala Arg Leu Met Gln Asp Leu Pro Ser Gly Gly Ala Met 
        595                 600                 605             


Val Ser Val Arg Val Ser Glu Glu Ala Ala Arg Ala Val Leu Arg Asp 
    610                 615                 620                 


Gly Val Glu Ile Ala Ala Val Asn Gly Pro Gln Ala Ile Val Leu Ser 
625                 630                 635                 640 


Gly Asp Glu Asp Ala Val Leu Ala Ala Ala Ala Glu Leu Gly Glu Phe 
                645                 650                 655     


Arg Arg Leu Arg Thr Ser His Ala Phe His Ser Gly Arg Met Glu Pro 
            660                 665                 670         


Met Leu Glu Glu Phe Arg Leu Val Ala Ser Ser Val Val Phe Arg Glu 
        675                 680                 685             


Pro Glu Ile Ala Met Ser Phe Val Pro Ser Ala Asp Tyr Phe Val Arg 
    690                 695                 700                 


Gln Val Arg Glu Thr Val Arg Phe Gly Glu Gln Val Ala Ser Phe Asp 
705                 710                 715                 720 


Ala Gly Ala Val Phe Val Glu Val Gly Pro Asp Gly Ser Leu Ser Arg 
                725                 730                 735     


Leu Thr Gly Gly Val Ser Ala Ala Glu Pro Leu Thr Ala Leu Ala Tyr 
            740                 745                 750         


Leu Trp Val Arg Gly Val Gly Val Asp Trp Ala Pro Tyr Val Gly Gly 
        755                 760                 765             


Gly Arg Leu Asp Leu Gly Ala Pro Thr Tyr Pro Phe Gln Arg Glu Arg 
    770                 775                 780                 


Tyr Trp Val Arg Pro Arg Leu Ala Gly Arg Thr Thr Asp Glu Arg Asp 
785                 790                 795                 800 


Ala Leu Leu Ile Ser Leu Val Arg Asp Asp Val Ala Ser Val Leu Gly 
                805                 810                 815     


His Pro Asp Arg Arg Arg Leu Ala Thr Asp Arg Pro Leu Leu Glu Leu 
            820                 825                 830         


Gly Phe Asp Ser Leu Thr Ala Leu Arg Leu Arg Asn Arg Leu Ala Ala 
        835                 840                 845             


Ala Thr Asp Ile Ala Leu Pro Ala Thr Leu Ile Phe Asp Tyr Pro Asn 
    850                 855                 860                 


Ile Gln Ala Ile Ala Val His Leu 
865                 870         


<210>  137
<211>  898
<212>  PRT
<213>  Actinoplanes sp.

<400>  137

Glu Pro Leu Ala Val Val Gly Met Ala Cys Arg Tyr Pro Gly Gly Val 
1               5                   10                  15      


Ala Ser Ala Asp Asp Leu Trp Arg Leu Val Thr Ala Gly Gly Asp Ala 
            20                  25                  30          


Ile Gly Pro Phe Pro Asp Asp Arg Gly Trp Glu Leu Glu Ser Leu Val 
        35                  40                  45              


Asp Pro Asp Pro Glu Ala Val Gly Arg Ser Thr Thr Gly Gln Gly Gly 
    50                  55                  60                  


Phe Leu Ala Asp Ala Ala Gly Phe Asp Ala Ala Phe Phe Gly Ile Ser 
65                  70                  75                  80  


Pro Arg Glu Ala Thr Ala Met Asp Pro Gln Gln Arg Leu Leu Leu Glu 
                85                  90                  95      


Val Ser Trp Ala Ala Leu Glu His Ala Gly Leu Arg Ala Asp Ala Leu 
            100                 105                 110         


Arg Gly Ser Ala Thr Gly Val Phe Met Gly Ser Asn Gly Gln Asp Tyr 
        115                 120                 125             


Ala Gly Leu Leu Ala Gly Ala Pro Glu Leu Glu Gly Trp Ile Gly Thr 
    130                 135                 140                 


Gly Val Ser Ala Ser Val Val Ser Gly Arg Leu Ser Tyr Phe Tyr Gly 
145                 150                 155                 160 


Phe Glu Gly Pro Ala Val Thr Val Asp Thr Ala Cys Ser Ser Ser Leu 
                165                 170                 175     


Val Ala Leu His Leu Ala Ala Gln Ser Leu Arg Thr Gly Glu Ser Ser 
            180                 185                 190         


Leu Ala Leu Val Gly Gly Val Thr Val Met Thr Ser Pro Thr Val Phe 
        195                 200                 205             


Arg Ser Phe Ser Arg Gln Arg Gly Leu Ala Pro Asp Gly Arg Cys Lys 
    210                 215                 220                 


Ala Phe Ser Ala Gly Ala Asp Gly Thr Gly Trp Ser Glu Gly Val Gly 
225                 230                 235                 240 


Val Leu Val Val Glu Arg Leu Ser Asp Ala Arg Arg Asn Asn His Gln 
                245                 250                 255     


Ile Leu Ala Leu Val Arg Gly Ser Ala Val Asn Gln Asp Gly Ala Ser 
            260                 265                 270         


Asn Gly Leu Thr Ala Pro Asn Gly Pro Ser Gln Gln Arg Val Ile Thr 
        275                 280                 285             


Ala Ala Leu Thr Asp Ala Arg Leu Thr Thr Thr Asp Ile Asp Leu Val 
    290                 295                 300                 


Glu Ala His Gly Thr Gly Thr Thr Leu Gly Asp Pro Ile Glu Ala Gln 
305                 310                 315                 320 


Ala Ile Leu Ala Thr Tyr Gly Asn Arg Thr Thr Gly Asn Pro Val His 
                325                 330                 335     


Leu Gly Ser Val Lys Ser Asn Leu Gly His Thr Gln Ala Ala Ala Gly 
            340                 345                 350         


Ile Ala Gly Val Ile Lys Ala Ile Gln Ala Ile Arg His Thr Thr Met 
        355                 360                 365             


Pro Lys Ser Leu His Ile Asp Gln Pro Ser Pro His Val Asp Trp Thr 
    370                 375                 380                 


Ser Gly Arg Val Glu Leu Leu Thr Ser Asn Gln Pro Trp Pro Ala Thr 
385                 390                 395                 400 


Asp Arg Pro Arg Arg Ala Ala Val Ser Ser Phe Gly Val Ser Gly Thr 
                405                 410                 415     


Asn Ala His Val Ile Leu Glu Glu Ala Pro Ala Pro Ala Glu Ala Val 
            420                 425                 430         


Pro Pro Ile Arg Pro Val Val Ser Gly Pro Ala Leu Pro Leu Val Phe 
        435                 440                 445             


Ser Ala Arg Asp Ser Gly Ala Leu Ala Thr Arg Thr His Leu Ser Asp 
    450                 455                 460                 


Gly Pro Gly Val Ala Tyr Ala Leu Ala Thr Ser Arg Ser Met Phe Asp 
465                 470                 475                 480 


His Arg Ser Val Arg Ile Gly Asp Met Thr Val Thr Gly Val Ala Thr 
                485                 490                 495     


Thr Asp Pro Glu Val Val Phe Val Phe Pro Gly Gln Gly Thr Gln Trp 
            500                 505                 510         


Ala Gly Met Gly Arg Ala Leu Met Asp Ala Ser Pro Val Phe Ala Glu 
        515                 520                 525             


Arg Met Asn Glu Cys Ala Ala Ala Leu Glu Pro Tyr Leu Asp Leu Trp 
    530                 535                 540                 


Ala Ala Ile Asp Ala Pro Asp Gln Val Glu Thr Leu Gln Pro Ala Ser 
545                 550                 555                 560 


Trp Ala Val Met Val Ser Leu Ala Ala Val Trp Gln Ala Ala Gly Val 
                565                 570                 575     


Arg Pro Ala Ala Val Ile Gly His Ser Gln Gly Glu Ile Ala Ala Ala 
            580                 585                 590         


Cys Val Ala Gly Ser Ile Thr Leu Gln Asp Ala Ala Ala Val Val Ala 
        595                 600                 605             


Leu Arg Ser Lys Ala Ile Ala Ala Ser Leu Gly Lys Gly Ala Met Ala 
    610                 615                 620                 


Ser Ile Pro Leu Pro Val Glu Glu Ile Glu Leu Ile Asp Glu Val Trp 
625                 630                 635                 640 


Val Ala Ala Leu Asn Gly Pro Ser Ser Thr Val Val Ala Gly Ala Pro 
                645                 650                 655     


Asp Ala Val Glu Gln Val Arg Ala Arg Tyr Asp Gly Arg Arg Ile Ala 
            660                 665                 670         


Val Asp Tyr Ala Ser His Thr Pro His Val Glu Ala Leu Arg Gly Gln 
        675                 680                 685             


Val Val Ser Val Pro Ser Gln Thr Pro Ala Val Pro Trp Phe Ser Thr 
    690                 695                 700                 


Val Asp Ser Glu Trp Val Glu Gly Gln Leu Asp Asp Asp Tyr Trp Phe 
705                 710                 715                 720 


Arg Asn Leu Arg Gln Pro Val Gln Phe Gly Pro Ala Ala Ala Arg Phe 
                725                 730                 735     


Asp Asp Ala Val Phe Ile Glu Val Ser Ala Arg Pro Val Leu Ile Pro 
            740                 745                 750         


Ala Leu Asp Ala Ser Val Thr Val Pro Ser Leu Arg Arg Asp Asp Gly 
        755                 760                 765             


Gly Pro Glu Arg Met Leu Ala Ser Leu Ala Gln Ala Phe Val Ala Gly 
    770                 775                 780                 


Val Ala Val Asp Trp Thr Thr Ile Val Pro Pro Ala Pro Phe Val Asp 
785                 790                 795                 800 


Leu Pro Thr Tyr Pro Phe Gln His Glu Arg Phe Trp Ile Glu Gly Arg 
                805                 810                 815     


Val Ala Ala Ala Thr Gly Ala Glu Arg Pro Arg Ile Leu Leu Glu Val 
            820                 825                 830         


Val Leu Ala Glu Thr Ala Thr Val Leu Gly His Gly Gly Ala Ala Ala 
        835                 840                 845             


Ile Gly Pro Asp Arg Ala Phe Gln Asp Leu Gly Phe Asp Ser Leu Thr 
    850                 855                 860                 


Ala Val Glu Leu Arg Asn Arg Leu Ala Ala Ala Thr Ala Leu Thr Leu 
865                 870                 875                 880 


Pro Thr Thr Leu Val Phe Asn His Pro Thr Pro Glu Ala Leu Ala Ala 
                885                 890                 895     


His Leu 
        


<210>  138
<211>  944
<212>  PRT
<213>  Actinoplanes sp.

<400>  138

Glu Leu Val Ala Ile Val Gly Met Ala Cys Arg Leu Pro Gly Asp Val 
1               5                   10                  15      


Ala Ser Pro Glu Asp Leu Trp Arg Leu Val Ala Glu Gly Arg Asp Ala 
            20                  25                  30          


Val Gly Pro Phe Pro Ala Asp Arg Gly Trp Asn Leu Gly Thr Leu Asp 
        35                  40                  45              


Asp Pro Asp Ala Ala Gly Arg Ser Tyr Val Lys Glu Gly Gly Phe Leu 
    50                  55                  60                  


Ala Gly Ala Ala His Phe Asp Pro Gly Phe Phe Gly Ile Gly Pro Arg 
65                  70                  75                  80  


Glu Ala Leu Gly Met Asp Pro Gln Gln Arg Ile Leu Leu Glu Ile Ala 
                85                  90                  95      


Trp Glu Ser Leu Glu Arg Ala Arg Ile Ala Pro Gly Ser Leu Arg Gly 
            100                 105                 110         


Ser Glu Thr Gly Val Tyr Val Gly Ala Ala Ala Gln Gly Tyr Gly Val 
        115                 120                 125             


Asp Ala Pro Leu Glu Gly Asn Leu Leu Thr Gly Gly Ser Thr Ser Ala 
    130                 135                 140                 


Met Ser Gly Arg Val Ala Tyr Ser Leu Gly Leu His Gly Pro Ala Val 
145                 150                 155                 160 


Thr Ile Asp Thr Ala Cys Ser Ser Ser Leu Val Ala Leu His Leu Ala 
                165                 170                 175     


Ala Gln Ala Leu Arg Asn Gly Glu Cys Thr Leu Ala Leu Ala Gly Gly 
            180                 185                 190         


Val Ala Val Met Ala Ser Pro Val Leu Phe Thr Glu Phe Ser Arg Gln 
        195                 200                 205             


Arg Gly Leu Ala Pro Asp Gly Arg Cys Lys Ala Phe Ala Ala Ala Ala 
    210                 215                 220                 


Asp Gly Thr Gly Trp Ser Glu Gly Ala Gly Leu Val Val Leu Glu Arg 
225                 230                 235                 240 


Leu Ser Asp Ala Glu Arg His Gly His Pro Val Leu Ala Val Ile Arg 
                245                 250                 255     


Gly Ser Ala Val Asn Ser Asp Gly Ala Ser Asn Gly Leu Thr Ala Pro 
            260                 265                 270         


Asn Gly Thr Ala Gln Arg Arg Val Ile Arg Ser Ala Leu Arg Ala Ala 
        275                 280                 285             


Gly Leu Gly Ala Gly Asp Val Asp Val Val Glu Ala His Gly Thr Gly 
    290                 295                 300                 


Thr Thr Leu Gly Asp Pro Val Glu Ala Asp Ala Leu Ile Ala Thr Tyr 
305                 310                 315                 320 


Gly Gln Arg Pro Gly Met Pro Pro Val Arg Ile Gly Ser Leu Lys Ser 
                325                 330                 335     


Asn Ile Gly His Thr Val Ala Ala Ala Gly Val Ala Gly Val Ile Lys 
            340                 345                 350         


Met Val Glu Ala Met Arg His Asp Thr Met Pro Arg Thr Leu His Val 
        355                 360                 365             


Asp Arg Pro Thr Pro His Val Asp Trp Ser Ala Gly Ala Ala Glu Leu 
    370                 375                 380                 


Leu Thr Gly Glu Gln Pro Trp Pro Arg Gly Asp Arg Pro Arg Arg Ala 
385                 390                 395                 400 


Ala Val Ser Ala Phe Gly Leu Ser Gly Thr Asn Ala His Leu Ile Leu 
                405                 410                 415     


Glu Asp Val Ala Pro Gly Ala Ala Ser Gly Ala Glu Pro Pro Gly Ala 
            420                 425                 430         


Ala Asp Glu Thr Val Pro Leu Leu Leu Ser Ala Asp Asp Leu Pro Ala 
        435                 440                 445             


Val Arg Asp Gln Ala Ala Arg Leu Arg Ala Tyr Leu Leu Ala Arg Pro 
    450                 455                 460                 


Glu Leu Arg Met Arg Asp Val Ala Tyr Ala Leu Ala Thr Thr Arg Thr 
465                 470                 475                 480 


Ala Arg Pro His Arg Ala Ala Val Ala Ala Thr Glu Arg Glu Phe Leu 
                485                 490                 495     


Arg Glu Leu Ala Leu Leu Ala Ala Gly Asp Gln Gly Pro Gly Thr Gln 
            500                 505                 510         


Leu Gly Glu Ala Val Pro His Arg Arg Val Ala Phe Leu Phe Asp Gly 
        515                 520                 525             


Gln Gly Thr Gln Arg His Gly Met Gly Arg Ala Leu His Gln Arg His 
    530                 535                 540                 


Pro Val Phe Ala Ala Ala Trp Asp Glu Val Cys Ala Ala Leu Asp Pro 
545                 550                 555                 560 


Leu Leu Gly Arg Gly Val Ala Asp Val Tyr Phe Ala Glu Ala Gly Arg 
                565                 570                 575     


Asp Leu Ala Asp Asp Pro Leu Tyr Thr Gln Ala Gly Leu Phe Ala Leu 
            580                 585                 590         


Glu Val Ala Leu Tyr Arg Leu Leu Thr Ser Trp Gly Val Thr Pro Asp 
        595                 600                 605             


Ala Val Ala Gly His Ser Val Gly Glu Val Ala Ala Ala His Val Ala 
    610                 615                 620                 


Gly Val Leu Ser Leu Pro Asp Ala Ala Ala Leu Leu Ala Ala Arg Gly 
625                 630                 635                 640 


Ala Ala Leu Arg Arg Leu Pro Ala Gly Ala Met Ala Ala Ile Arg Ala 
                645                 650                 655     


Ser Glu Ala Asp Thr Arg Ala Val Leu Pro Pro Asp Leu Asp Val Ala 
            660                 665                 670         


Ala Val Asn Gly Pro Glu Met Thr Val Val Ser Gly Ala Pro Asp Ala 
        675                 680                 685             


Val Asp Arg Phe Ile Ala Glu Gln Ala Gly Ala Gly Arg Gln Val Arg 
    690                 695                 700                 


Arg Leu Arg Val Gly Arg Ala Tyr His Ser Arg His Val Asp Ala Val 
705                 710                 715                 720 


Leu Ala Glu Phe Gly Ala Thr Leu Ser Ala Leu Thr Phe His Glu Pro 
                725                 730                 735     


Val Leu Pro Val Val Ser Thr Val Thr Gly Arg Pro Ala Gly Ala Gly 
            740                 745                 750         


Asp Leu Thr Thr Pro Glu Tyr Trp Leu Arg His Ala Arg Arg Pro Val 
        755                 760                 765             


Arg Phe Gly Ala Ala Leu Ala Ala Leu Ser Glu Leu Gly Met Asp Ser 
    770                 775                 780                 


Phe Val Glu Val Gly Pro Ser Gly Ser Leu Ser Ser Met Ala Gly Glu 
785                 790                 795                 800 


Thr Val Ala Gly Thr Phe His Pro Met Leu Asp Arg Arg Val Pro Asp 
                805                 810                 815     


Glu Ile Ala Val Ala Ala Gly Glu Leu Phe Thr Ala Gly Met Val Leu 
            820                 825                 830         


Asp Trp Ala Ala Val Leu Ala Gly Gly Arg Thr Ile Asp Leu Pro Val 
        835                 840                 845             


Tyr Pro Phe Arg Arg Glu Phe Tyr Trp Leu Gly Ala Arg Arg Tyr Asp 
    850                 855                 860                 


Leu Met Ala Ala Ala Glu Arg Arg Asp Ala Leu Leu Asp Leu Val Arg 
865                 870                 875                 880 


Val Gln Val Ala Leu Leu Leu Gly Arg Ala Asp Ala Ile Gly Val Arg 
                885                 890                 895     


Asp Asn Thr Ser Phe Leu Asp Val Gly Leu Asp Ser Leu Gly Ala Ser 
            900                 905                 910         


Arg Leu Arg Asn Arg Leu Ala Ala Ala Thr Gly Leu Thr Leu Pro Gly 
        915                 920                 925             


Gly Val Ala Phe Asp His Pro Thr Pro Ala Arg Leu Ala Asp His Leu 
    930                 935                 940                 


<210>  139
<211>  863
<212>  PRT
<213>  Actinoplanes sp.

<400>  139

Glu Pro Leu Ala Ile Val Gly Met Ala Cys Arg Leu Pro Gly Gly Val 
1               5                   10                  15      


Ser Ser Pro Glu Asp Leu Trp Arg Leu Val Glu Ser Gly Thr Asp Ala 
            20                  25                  30          


Thr Ser Gly Phe Pro Val Asp Arg Gly Trp Ala Asp Ser Ser Met Arg 
        35                  40                  45              


Gly Gly Phe Leu Asp Ala Ala Ala Asp Phe Asp Ala Ala Phe Phe Gly 
    50                  55                  60                  


Ile Ser Pro Arg Glu Ala Leu Ala Met Asp Pro Gln Gln Arg Leu Val 
65                  70                  75                  80  


Leu Glu Ala Ser Trp Glu Ala Phe Glu Arg Ala Gly Ile Glu Pro Gly 
                85                  90                  95      


Ser Val Arg Gly Ser Asp Thr Gly Val Phe Met Gly Ala Phe Ser Gly 
            100                 105                 110         


Gly Tyr Gly Ala Gly Ala Asp Leu Gly Gly Phe Gly Val Thr Ala Gly 
        115                 120                 125             


Ala Val Ser Val Leu Ser Gly Arg Val Ser Tyr Phe Phe Gly Leu Glu 
    130                 135                 140                 


Gly Pro Ala Val Thr Val Asp Thr Ala Cys Ser Ser Ser Leu Val Ala 
145                 150                 155                 160 


Leu His Gln Ala Gly His Ala Leu Arg Gln Gly Glu Cys Ser Leu Ala 
                165                 170                 175     


Leu Val Gly Gly Val Thr Val Met Ser Thr Pro Asp Ile Phe Ala Glu 
            180                 185                 190         


Phe Ser Arg Gln Gly Gly Leu Ala Ser Asp Gly Arg Cys Lys Ala Phe 
        195                 200                 205             


Ala Asp Thr Ala Asp Gly Thr Ser Trp Ser Glu Gly Val Gly Val Leu 
    210                 215                 220                 


Val Val Glu Arg Leu Ser Asp Ala Arg Ala Lys Gly His Gln Val Leu 
225                 230                 235                 240 


Ala Val Val Arg Gly Ser Ala Val Asn Gln Asp Gly Ala Ser Asn Gly 
                245                 250                 255     


Leu Thr Ala Pro Asn Gly Pro Ser Gln Gln Arg Val Ile Gln Ala Ala 
            260                 265                 270         


Leu Thr His Ala Gly Leu Thr Thr Ala Glu Val Asp Val Val Glu Ala 
        275                 280                 285             


His Gly Thr Gly Thr Thr Leu Gly Asp Pro Ile Glu Ala Gln Ala Val 
    290                 295                 300                 


Ile Ala Thr Tyr Gly Arg Asp Arg Glu Arg Pro Val Leu Leu Gly Ser 
305                 310                 315                 320 


Leu Lys Ser Asn Val Gly His Thr Gln Ala Ala Ala Gly Val Ser Gly 
                325                 330                 335     


Val Ile Lys Met Val Met Ala Leu Gln His Gly Val Val Pro Arg Thr 
            340                 345                 350         


Leu His Val Asp Glu Pro Ser Arg His Val Asp Trp Thr Ala Gly Ala 
        355                 360                 365             


Val Arg Leu Ala Thr Glu Ser Gln Pro Trp Pro Asp Thr Gly Arg Pro 
    370                 375                 380                 


Arg Arg Ala Ala Val Ser Ser Phe Gly Val Ser Gly Thr Asn Ala His 
385                 390                 395                 400 


Val Ile Leu Glu Gly Val Ala Glu Glu Pro Ala Gln Ser Glu Glu Ser 
                405                 410                 415     


Ser Glu Leu Val Pro Leu Val Ile Ser Ala Lys Thr Pro Ala Ala Leu 
            420                 425                 430         


Thr Arg Leu Glu Glu Arg Leu Arg Ala Tyr Leu Thr Ala Glu Ser Asn 
        435                 440                 445             


Leu Ser Ala Val Ala Ser Thr Leu Ala Glu Thr Arg Ser Leu Phe Glu 
    450                 455                 460                 


His Arg Ala Val Leu Leu Gly Asp Asp Thr Ile Lys Gly Thr Ala Gln 
465                 470                 475                 480 


Pro Asn Pro Arg Val Val Phe Val Phe Ser Gly Gln Gly Ser Gln Arg 
                485                 490                 495     


Ala Gly Met Gly Asp Glu Leu Ala Ala Ala Phe Pro Val Phe Ala Lys 
            500                 505                 510         


Ile Arg Gln Gln Val Trp Asp Leu Leu Asp Val Pro Asp Leu Glu Val 
        515                 520                 525             


Asn Asp Thr Gly His Ala Gln Pro Ala Leu Phe Ala Leu Gln Val Ala 
    530                 535                 540                 


Leu Phe Gly Leu Leu Glu Ser Trp Gly Val Arg Pro Gln Ala Leu Ile 
545                 550                 555                 560 


Gly His Ser Ile Gly Glu Leu Ala Ala Gly Tyr Val Ser Gly Ile Trp 
                565                 570                 575     


Ser Leu Glu Asp Ala Cys Thr Leu Val Ser Ala Arg Ala Arg Leu Met 
            580                 585                 590         


Gln Ser Leu Pro Pro Gly Gly Ala Met Val Ala Val Pro Val Ser Glu 
        595                 600                 605             


Gln Gln Ala Arg Ala Val Leu Thr Asp Gly Val Glu Ile Ala Ala Val 
    610                 615                 620                 


Asn Gly Pro Ser Ser Val Val Leu Ser Gly Asp Glu Glu Ala Val Leu 
625                 630                 635                 640 


Arg Ala Ala Ala Ala Leu Asp Gly Arg Ser Lys Arg Leu Val Thr Ser 
                645                 650                 655     


His Ala Phe His Ser Ala Arg Met Glu Pro Met Leu Asp Glu Phe Arg 
            660                 665                 670         


Ala Val Ala Glu Gln Leu Thr Tyr Arg Ala Pro Arg Ile Pro Met Ala 
        675                 680                 685             


Val Gly Glu Gly Pro Glu Tyr Trp Val Arg Gln Val Arg Glu Thr Val 
    690                 695                 700                 


Arg Phe Gly Glu Gln Val Ala Ala His Asp Gly Ala Val Phe Val Glu 
705                 710                 715                 720 


Leu Gly Pro Glu Gly Thr Leu Ala Arg Leu Ile Asp Gly Val Ala Val 
                725                 730                 735     


Leu Asp Arg Glu Asp Glu Pro Arg Ala Ala Leu Thr Ala Leu Gly Lys 
            740                 745                 750         


Leu His Val Arg Gly Val Arg Val Asp Trp Pro Leu Thr Ser Gly Arg 
        755                 760                 765             


Arg Val Asp Leu Pro Thr Tyr Ala Phe Gln Arg Glu Arg Tyr Trp Ala 
    770                 775                 780                 


Thr Ala Leu Thr Pro Ala Glu Arg Glu Gln Ala Leu Leu Lys Leu Val 
785                 790                 795                 800 


Arg Asp Ser Ala Ala Val Val Leu Gly Tyr Thr Asp Ala Val Pro Val 
                805                 810                 815     


Ser Gly Ser Phe Lys Asp Leu Gly Ile Asp Ser Leu Thr Ala Val Glu 
            820                 825                 830         


Leu Arg Asn Ser Leu Ala Thr Thr Thr Gly Leu Arg Leu Pro Ala Thr 
        835                 840                 845             


Leu Val Phe Asp Tyr Pro Thr Pro Ala Thr Leu Ala Ala Arg Leu 
    850                 855                 860             


<210>  140
<211>  904
<212>  PRT
<213>  Actinoplanes sp.

<400>  140

Glu Pro Leu Ala Ile Val Gly Met Ala Cys Arg Leu Pro Gly Gly Val 
1               5                   10                  15      


Ser Ser Pro Glu Asp Leu Trp Arg Leu Val Glu Ser Gly Thr Asp Ala 
            20                  25                  30          


Ile Ala Pro Phe Pro Thr Asp Arg Gly Trp Asp Val Glu Ala Leu Phe 
        35                  40                  45              


Asp Pro Asp Pro Asp Ala Ala Gly Lys Ser Tyr Cys Val Arg Gly Gly 
    50                  55                  60                  


Phe Leu Asp Gly Val Ala Asp Phe Asp Ala Ser Phe Phe Gly Ile Ser 
65                  70                  75                  80  


Pro Arg Glu Ala Leu Ala Met Asp Pro Gln Gln Arg Leu Ile Leu Glu 
                85                  90                  95      


Ala Ser Trp Glu Ala Phe Glu Arg Ala Gly Ile Asp Pro Ala Asp Ala 
            100                 105                 110         


Arg Gly Ser Asp Thr Gly Val Phe Met Gly Ala Phe Thr Ser Gly Tyr 
        115                 120                 125             


Gly Ala Asp Leu Glu Gly Phe Gly Gly Thr Ala Gly Ala Leu Ser Val 
    130                 135                 140                 


Leu Ser Gly Arg Val Ser Tyr Phe Phe Gly Leu Glu Gly Pro Ala Val 
145                 150                 155                 160 


Thr Val Asp Thr Ala Cys Ser Ser Ser Leu Phe Ala Leu His Gln Ala 
                165                 170                 175     


Gly Tyr Ala Leu Arg Gln Gly Glu Cys Ser Met Ala Leu Val Gly Gly 
            180                 185                 190         


Val Thr Val Met Ala Thr Pro Arg Thr Phe Val Glu Phe Ser Arg Gln 
        195                 200                 205             


Arg Gly Leu Ala Ser Asp Gly Arg Cys Lys Ala Phe Gly Asp Thr Ala 
    210                 215                 220                 


Asp Gly Thr Gly Trp Ala Glu Gly Val Gly Val Leu Val Val Glu Arg 
225                 230                 235                 240 


Leu Ser Asp Ala Gln Ala Lys Gly His Arg Val Leu Ala Val Val Arg 
                245                 250                 255     


Gly Ser Ala Val Asn Gln Asp Gly Ala Ser Asn Gly Leu Thr Ala Pro 
            260                 265                 270         


Asn Gly Pro Ser Gln Gln Arg Val Ile Gln Ala Ala Leu His Asn Ala 
        275                 280                 285             


Arg Leu Thr Pro Ala Asp Val Asp Val Val Glu Ala His Gly Thr Gly 
    290                 295                 300                 


Thr Thr Leu Gly Asp Pro Ile Glu Ala Gln Ala Val Ile Ala Ala Tyr 
305                 310                 315                 320 


Gly Gln Gly Arg Asp Glu Pro Leu Leu Leu Gly Ser Leu Lys Ser Asn 
                325                 330                 335     


Val Gly His Thr Gln Ala Ala Ala Gly Val Ser Gly Val Ile Lys Met 
            340                 345                 350         


Val Met Ala Leu Gln His Gly Val Val Pro Arg Thr Leu His Val Asp 
        355                 360                 365             


Glu Pro Ser Arg His Val Asp Trp Thr Ala Gly Glu Val Arg Leu Val 
    370                 375                 380                 


Thr Glu Asn Gln Ser Trp Pro Asp Thr Gly Arg Pro Arg Arg Ala Gly 
385                 390                 395                 400 


Val Ser Ala Phe Gly Val Ser Gly Thr Asn Ala His Val Ile Leu Glu 
                405                 410                 415     


Gly Pro Pro Thr Gln Pro Pro Ala Thr Ala Pro Gln Glu Pro Ala Pro 
            420                 425                 430         


Leu Val Ile Ser Ala Lys Thr Pro Ala Ala Leu Ala Asp Tyr Glu Gly 
        435                 440                 445             


Arg Leu Arg Ala Tyr Leu Ala Ala Thr Pro Gly Thr Asp Ala Arg Ala 
    450                 455                 460                 


Leu Ala Val Thr Arg Ser Leu Phe Glu His Arg Ala Val Leu Leu Gly 
465                 470                 475                 480 


Asp Asp Thr Ile Ser Gly Ala Ala Val Thr Asp Pro Arg Val Val Phe 
                485                 490                 495     


Val Phe Pro Gly Gln Gly Trp Gln Trp Leu Gly Met Gly Val Ala Leu 
            500                 505                 510         


Arg Asp Ser Ser Val Val Phe Ala Glu Arg Met Thr Glu Cys Ala Ala 
        515                 520                 525             


Ala Leu Ser Glu Phe Val Asp Trp Asp Leu Phe Ala Val Leu Asp Asp 
    530                 535                 540                 


Pro Ala Val Val Asp Arg Val Asp Val Val Gln Pro Ala Cys Trp Ala 
545                 550                 555                 560 


Val Met Val Ser Leu Ala Ala Val Trp Gln Ala Ala Gly Val His Pro 
                565                 570                 575     


Asp Ala Val Val Gly His Ser Gln Gly Glu Ile Ala Ala Ala Cys Val 
            580                 585                 590         


Ala Gly Ala Ile Ser Leu Arg Asp Ala Ala Arg Val Val Ala Leu Arg 
        595                 600                 605             


Ser Arg Leu Ile Gly Glu Arg Leu Gly Gln Gly Ala Met Ala Ser Val 
    610                 615                 620                 


Thr Leu Pro Ala Asp Glu Ile Ser Leu Val Asp Gly Val Trp Ile Ala 
625                 630                 635                 640 


Ala Tyr Asn Gly Pro Ala Ser Thr Val Ile Ala Gly Ser Pro Asp Ala 
                645                 650                 655     


Val Asp Gln Met Val Gly Asp Arg Val Arg Arg Ile Ala Val Asp Tyr 
            660                 665                 670         


Ala Ser His Ser Pro Gln Val Glu Gln Ile Lys Asp Glu Leu Leu Asp 
        675                 680                 685             


Ile Thr Ala Asp Val Gly Ser Arg Thr Pro Thr Val Pro Trp Phe Ser 
    690                 695                 700                 


Thr Val Asp Gly Ser Trp Ile Glu Gly Pro Leu Asp Ala Asp Tyr Trp 
705                 710                 715                 720 


Tyr Arg Asn Leu Arg Gln Pro Val Gly Phe His Pro Ala Val Glu Ala 
                725                 730                 735     


Leu Arg Ala Leu Gly Glu Thr Val Phe Val Glu Val Ser Ala Ser Pro 
            740                 745                 750         


Val Leu Leu Pro Ala Met Asp Asp Ala Leu Thr Val Ala Thr Leu Arg 
        755                 760                 765             


Arg Asp Asp Gly Thr Ile Ala Arg Met His Thr Ala Leu Ala Glu Ala 
    770                 775                 780                 


His Val His Gly Val Asn Val Asp Trp Ala Ala Val Leu Gly Val Ala 
785                 790                 795                 800 


Ala Arg His Val Asp Leu Pro Thr Tyr Ala Phe Gln Arg Gln Arg Phe 
                805                 810                 815     


Trp Ala Asp Glu Arg Glu Leu Ala Ser Leu Gly Pro Ala Glu Arg Glu 
            820                 825                 830         


Gln Ala Leu Arg Lys Leu Val Ser Asp Thr Ala Ala Gly Val Leu Gly 
        835                 840                 845             


Tyr Ala Asp Pro Gly Ala Val Pro Ile Lys Ala Ala Phe Arg Glu Leu 
    850                 855                 860                 


Gly Val Asp Ser Leu Thr Ala Val Glu Leu Arg Asn Gly Leu Ala Lys 
865                 870                 875                 880 


Ala Thr Gly Met Arg Leu Pro Ala Thr Met Val Phe Asp Tyr Pro Thr 
                885                 890                 895     


Pro His Ala Leu Ala Ala Arg Leu 
            900                 


<210>  141
<211>  909
<212>  PRT
<213>  Actinoplanes sp.

<400>  141

Glu Pro Leu Ala Ile Val Gly Met Ala Cys Arg Leu Pro Gly Gly Val 
1               5                   10                  15      


Ser Ser Pro Glu Asp Leu Trp Arg Leu Val Glu Ser Gly Thr Asp Ala 
            20                  25                  30          


Ile Ser Glu Phe Pro Ala Asp Arg Gly Trp Asp Val Glu Asn Leu Tyr 
        35                  40                  45              


Asp Pro Asp Pro Asp Ala Ala Gly Lys Ser Tyr Cys Val Arg Gly Gly 
    50                  55                  60                  


Phe Leu Asp Ala Ala Ala Glu Phe Asp Ala Ser Phe Phe Gly Ile Ser 
65                  70                  75                  80  


Pro Arg Glu Ala Leu Ala Met Asp Pro Gln Gln Arg Leu Ile Leu Glu 
                85                  90                  95      


Ala Ser Trp Glu Ala Phe Glu Arg Ala Gly Ile Glu Pro Gly Ser Val 
            100                 105                 110         


Arg Gly Ser Asp Thr Gly Val Phe Met Gly Ala Phe Ser Gly Gly Tyr 
        115                 120                 125             


Gly Ala Asp Val Glu Gly Phe Gly Ala Thr Ala Gly Ala Gly Ser Val 
    130                 135                 140                 


Leu Ser Gly Arg Val Ser Tyr Phe Phe Gly Leu Glu Gly Pro Ala Ile 
145                 150                 155                 160 


Thr Val Asp Thr Ala Cys Ser Ser Ser Leu Val Ala Leu His Gln Ala 
                165                 170                 175     


Gly Tyr Ser Leu Arg Gln Gly Glu Cys Ser Leu Ala Leu Val Gly Gly 
            180                 185                 190         


Ala Thr Val Met Ala Lys Pro Gln Ser Phe Val Glu Phe Ser Arg Gln 
        195                 200                 205             


Arg Gly Leu Ala Ala Asp Gly Arg Cys Lys Ala Phe Ala Asp Ala Ala 
    210                 215                 220                 


Asp Gly Thr Gly Trp Ala Glu Gly Val Gly Val Leu Leu Val Glu Arg 
225                 230                 235                 240 


Leu Ser Asp Ala Glu Arg Asn Gly His Gln Val Leu Ala Val Val Arg 
                245                 250                 255     


Ser Ser Ala Val Asn Gln Asp Gly Ala Ser Asn Gly Leu Ser Ala Pro 
            260                 265                 270         


Asn Gly Pro Ser Gln Gln Arg Val Ile Arg Gln Ala Leu Ala Asn Ala 
        275                 280                 285             


Arg Leu Thr Ala Ala Asp Val Asp Val Val Glu Ala His Gly Thr Gly 
    290                 295                 300                 


Thr Thr Leu Gly Asp Pro Ile Glu Ala Gln Ala Leu Ile Ala Ala Tyr 
305                 310                 315                 320 


Gly Gln Asp Arg Glu Trp Pro Leu Leu Leu Gly Ser Leu Lys Ser Asn 
                325                 330                 335     


Val Gly His Thr Gln Ala Ala Ala Gly Val Ser Gly Val Ile Lys Met 
            340                 345                 350         


Val Met Ala Leu Gln His Gly Val Val Pro Arg Thr Leu His Val Asp 
        355                 360                 365             


Glu Pro Ser Arg His Val Asp Trp Thr Ala Gly Ala Val Arg Leu Val 
    370                 375                 380                 


Thr Asp Asn Gln Pro Trp Pro Glu Thr Gly Arg Pro Arg Arg Ala Gly 
385                 390                 395                 400 


Val Ser Ser Phe Gly Val Ser Gly Thr Asn Ala His Val Ile Leu Glu 
                405                 410                 415     


Ser Pro Pro Thr Gln Pro Ser Gly Thr Phe Lys Lys Pro Ala His Glu 
            420                 425                 430         


Pro Gln Pro Leu Ile Ile Ser Ala Lys Thr Pro Ala Ala Leu Ala Asp 
        435                 440                 445             


Tyr Glu Asp Arg Leu Gly Ala Tyr Leu Thr Ala Ala Pro Gly Val Asp 
    450                 455                 460                 


Val Pro Ala Val Ala Ala Thr Leu Ala Val Thr Arg Ser Leu Phe Glu 
465                 470                 475                 480 


His Arg Ala Val Leu Leu Gly Asp Asn Thr Val Thr Gly Thr Ala Ile 
                485                 490                 495     


Thr Asp Pro Arg Val Val Phe Val Phe Pro Gly Gln Gly Trp Gln Trp 
            500                 505                 510         


Leu Gly Met Gly Ala Ala Leu Arg Gly Ser Ser Val Val Phe Ala Glu 
        515                 520                 525             


Arg Met Thr Glu Cys Ala Ala Ala Leu Ser Glu Phe Val Asp Trp Asp 
    530                 535                 540                 


Leu Phe Ala Val Leu Asp Asp Pro Ala Val Val Asp Arg Val Asp Val 
545                 550                 555                 560 


Val Gln Pro Ala Cys Trp Ala Val Met Val Ser Leu Ala Ala Val Trp 
                565                 570                 575     


Gln Ala Ala Gly Val His Pro Asp Ala Val Val Gly His Ser Gln Gly 
            580                 585                 590         


Glu Ile Ala Ala Ala Cys Val Ala Ser Ala Val Ser Leu Arg Asp Ala 
        595                 600                 605             


Ala Arg Val Val Ala Leu Arg Ser Arg Leu Ile Ser Glu Arg Leu Gly 
    610                 615                 620                 


Gln Gly Ala Met Ala Ser Val Ala Leu Pro Ala Asp Gln Ile Val Leu 
625                 630                 635                 640 


Ala Asp Gly Val Trp Ile Ala Ala His Asn Gly Pro Thr Ser Thr Val 
                645                 650                 655     


Val Ala Gly Ser Pro Asp Ala Val Glu Gln Met Leu Gly Asp Arg Val 
            660                 665                 670         


Arg Lys Ile Ala Val Asp Tyr Ala Ser His Thr Pro His Val Glu Gln 
        675                 680                 685             


Ile Lys Thr Glu Leu Leu Gly Ile Thr Ala Gly Ile Gly Ser Arg Thr 
    690                 695                 700                 


Pro Thr Val Pro Trp Phe Ser Thr Val Asp Gly Ser Trp Ile Glu Gly 
705                 710                 715                 720 


Pro Leu Asp Ala Asp Tyr Trp Tyr Arg Asn Leu Arg Gln Pro Val Gly 
                725                 730                 735     


Phe Asp Ala Ala Val Gly Arg Leu Arg Ala Leu Gly Ala Thr Val Phe 
            740                 745                 750         


Val Glu Val Ser Ala Ser Pro Val Leu Leu Pro Ala Met Asp Asp Ala 
        755                 760                 765             


Val Thr Ile Ala Thr Leu Arg Arg Asp Glu Gly Ser Ile Thr Arg Met 
    770                 775                 780                 


His Thr Ala Leu Ala Glu Ala His Val Leu Gly Val Asn Val Asp Trp 
785                 790                 795                 800 


Pro Thr Leu Leu Gly Asp Thr Asp Arg Arg Ala Leu Asp Leu Pro Thr 
                805                 810                 815     


Tyr Ala Phe Gln Arg Gln Arg Tyr Trp Gly Asp Ala Ala Gly Leu Ala 
            820                 825                 830         


Pro Ala Glu Arg Glu Gln Ala Leu Leu Lys Leu Val Arg Asp Ser Ala 
        835                 840                 845             


Ala Leu Val Leu Gly Tyr Ala Gly Gly Asp Ala Val Pro Ala Thr Asp 
    850                 855                 860                 


Ala Phe Lys Asp Leu Gly Ile Asp Ser Leu Thr Ala Val Glu Leu Arg 
865                 870                 875                 880 


Asn Gly Leu Ala Lys Ala Thr Gly Leu Arg Leu Pro Ala Thr Leu Val 
                885                 890                 895     


Phe Asp Tyr Pro Thr Pro Gln Val Leu Ala Ala Arg Leu 
            900                 905                 


<210>  142
<211>  867
<212>  PRT
<213>  Actinoplanes sp.

<400>  142

Glu Pro Leu Ala Ile Val Gly Met Ala Cys Arg Leu Pro Gly Gly Val 
1               5                   10                  15      


Ser Ser Pro Glu Asp Leu Trp Arg Leu Val Glu Ser Gly Thr Asp Ala 
            20                  25                  30          


Thr Ser Gly Phe Pro Val Asp Arg Gly Trp Ala Asp Ser Ser Met Arg 
        35                  40                  45              


Gly Gly Phe Leu Asp Ala Ala Ala Asp Phe Asp Ala Ala Phe Phe Gly 
    50                  55                  60                  


Ile Ser Pro Arg Glu Ala Leu Ala Met Asp Pro Gln Gln Arg Leu Val 
65                  70                  75                  80  


Leu Glu Ala Ser Trp Glu Ala Phe Glu Arg Ala Gly Ile Glu Pro Gly 
                85                  90                  95      


Ser Val Arg Gly Ser Asp Ile Gly Val Phe Met Gly Ala Tyr Pro Gly 
            100                 105                 110         


Gly Tyr Gly Ile Gly Ala Asp Leu Ala Gly Phe Gly Ala Thr Ala Gly 
        115                 120                 125             


Ala Gly Ser Val Leu Ser Gly Arg Val Ser Tyr Phe Phe Gly Leu Glu 
    130                 135                 140                 


Gly Pro Ala Val Thr Val Asp Thr Ala Cys Ser Ser Ser Leu Val Ala 
145                 150                 155                 160 


Leu His Gln Ala Gly His Ala Leu Arg Leu Gly Glu Cys Ser Leu Ala 
                165                 170                 175     


Leu Val Gly Gly Val Thr Val Met Ala Thr Pro Asp Thr Phe Val Glu 
            180                 185                 190         


Phe Ala Arg Gln Gly Gly Leu Ala Ser Asp Gly Arg Ser Lys Ala Phe 
        195                 200                 205             


Ala Asp Ser Ala Asp Gly Ala Gly Phe Ser Glu Gly Val Gly Val Leu 
    210                 215                 220                 


Leu Val Glu Arg Leu Ser Asp Ala Gln Arg His Gly His Arg Val Leu 
225                 230                 235                 240 


Ala Val Val Arg Gly Ser Ala Val Asn Gln Asp Gly Ala Ser Asn Gly 
                245                 250                 255     


Leu Thr Ala Pro Asn Gly Pro Ser Gln Gln Arg Val Ile Gln Ala Ala 
            260                 265                 270         


Leu Ala His Ala Gly Leu Ala Pro His Glu Val Asp Val Val Glu Ala 
        275                 280                 285             


His Gly Thr Gly Thr Thr Leu Gly Asp Pro Ile Glu Ala Gln Ala Val 
    290                 295                 300                 


Ile Ala Thr Tyr Gly Gln Asp Arg Asp Glu Pro Leu Leu Leu Gly Ser 
305                 310                 315                 320 


Val Lys Ser Asn Val Gly His Thr Gln Ala Ala Ala Gly Val Ala Gly 
                325                 330                 335     


Val Ile Lys Met Val Met Ala Leu Arg His Gly Val Val Pro Gln Thr 
            340                 345                 350         


Leu His Val Asp Glu Pro Ser Arg His Val Asp Trp Thr Ala Gly Ala 
        355                 360                 365             


Val Arg Leu Leu Thr Glu Lys Gln Pro Trp Pro Ser Thr Asp Arg Pro 
    370                 375                 380                 


Arg Arg Ala Gly Val Ser Ser Phe Gly Ile Ser Gly Thr Asn Ala His 
385                 390                 395                 400 


Val Ile Leu Glu Gly Val Ala Glu Glu Pro Ala Gln Ser Glu Asp Ser 
                405                 410                 415     


Ser Glu Leu Val Pro Leu Val Ile Ser Ala Lys Thr Pro Ala Ala Leu 
            420                 425                 430         


Thr Gln Val Glu Glu Arg Leu Arg Ala Tyr Leu Thr Ala Glu Ser Asn 
        435                 440                 445             


Leu Ser Ala Val Ala Ser Thr Leu Ala Glu Thr Arg Ser Leu Phe Glu 
    450                 455                 460                 


His Arg Ala Val Leu Leu Asp Gly His Ala Val Arg Gly Val Ala Glu 
465                 470                 475                 480 


Ser Asn Pro Arg Val Val Phe Val Phe Ser Gly Gln Gly Ser Gln Arg 
                485                 490                 495     


Ala Gly Met Gly Asp Glu Leu Ala Ala Ala Phe Pro Val Phe Ala Lys 
            500                 505                 510         


Ile Arg Gly Gln Val Trp Asp Leu Leu Asp Val Pro Asp Leu Asp Val 
        515                 520                 525             


Asn Asp Thr Gly His Ala Gln Pro Ala Leu Phe Ala Leu Gln Val Ala 
    530                 535                 540                 


Leu Phe Gly Leu Leu Glu Ser Trp Gly Val Arg Pro His Ala Leu Ile 
545                 550                 555                 560 


Gly His Ser Ile Gly Glu Leu Ala Ala Gly Tyr Val Ser Gly Ile Trp 
                565                 570                 575     


Ser Leu Glu Asp Ala Cys Ala Leu Val Ser Ala Arg Ala Arg Leu Met 
            580                 585                 590         


Gln Ala Leu Pro Pro Gly Gly Ala Met Val Ala Val Pro Val Ser Glu 
        595                 600                 605             


Gln Gln Ala Arg Ala Val Leu Thr Asp Gly Val Glu Val Ala Ala Val 
    610                 615                 620                 


Asn Gly Pro Ser Ser Ala Val Leu Ser Gly Asp Glu Glu Ala Val Leu 
625                 630                 635                 640 


Arg Ala Ala Ala Ala Leu Gly Gly Arg Trp Lys Arg Leu Ala Thr Ser 
                645                 650                 655     


His Ala Phe His Ser Ala Arg Met Glu Pro Met Leu Asp Glu Phe Arg 
            660                 665                 670         


Ala Val Ala Glu Gln Leu Thr Tyr Arg Ala Pro Arg Ile Pro Met Ala 
        675                 680                 685             


Val Gly Glu Gly Pro Glu Tyr Trp Val Arg Gln Val Arg Glu Thr Val 
    690                 695                 700                 


Arg Phe Gly Glu Gln Val Ala Ala His Asp Gly Ala Val Phe Val Glu 
705                 710                 715                 720 


Leu Gly Pro Asp Gly Ser Leu Ala Arg Leu Ile Asp Gly Ile Ala Thr 
                725                 730                 735     


Leu Asp Arg Asp Asp Glu Pro Arg Val Ala Leu Thr Ala Leu Ala Glu 
            740                 745                 750         


Leu His Val Arg Gly Val Asp Val Asp Trp Pro Leu Thr Ser Gly Arg 
        755                 760                 765             


Arg Val Asp Leu Pro Thr Tyr Ala Phe Gln Arg Gln Arg Tyr Trp Ile 
    770                 775                 780                 


Asp Arg Ala Gly Arg Thr Pro Ala Glu Arg Glu Gln Ala Leu Leu Lys 
785                 790                 795                 800 


Val Val Arg Asp Ser Ala Ala Thr Val Leu Gly His Ala Asp Gly Gly 
                805                 810                 815     


Ser Val Gly Ala Ala Ala Ala Phe Lys Asp Leu Gly Val Asp Ser Leu 
            820                 825                 830         


Thr Ala Val Glu Leu Arg Asn Ser Leu Ala Lys Ala Thr Gly Leu Arg 
        835                 840                 845             


Leu Pro Ala Thr Leu Val Phe Asp Tyr Pro Thr Pro Ala Ala Val Ala 
    850                 855                 860                 


Val Arg Leu 
865         


<210>  143
<211>  900
<212>  PRT
<213>  Actinoplanes sp.

<400>  143

Glu Pro Leu Ala Ile Val Gly Met Ala Cys Arg Leu Pro Gly Gly Val 
1               5                   10                  15      


Ser Ser Pro Glu Asp Leu Trp Arg Leu Val Glu Ser Gly Thr Asp Ala 
            20                  25                  30          


Thr Ser Gly Phe Pro Thr Asp Arg Gly Trp Ala Asp Ser Ser Met Arg 
        35                  40                  45              


Gly Gly Phe Leu Val Ala Ala Ala Asp Phe Asp Ala Ala Phe Phe Gly 
    50                  55                  60                  


Ile Ser Pro Arg Glu Ala Leu Ala Met Asp Pro Gln Gln Arg Leu Val 
65                  70                  75                  80  


Leu Glu Ala Ser Trp Glu Ala Phe Glu Arg Ala Gly Ile Glu Pro Gly 
                85                  90                  95      


Thr Val Arg Gly Ser Asp Thr Gly Val Phe Met Gly Ala Tyr Pro Gly 
            100                 105                 110         


Gly Tyr Gly Ile Gly Ala Asp Leu Ala Gly Phe Gly Ala Thr Ala Gly 
        115                 120                 125             


Ala Gly Ser Val Leu Ser Gly Arg Val Ser Tyr Phe Phe Gly Leu Glu 
    130                 135                 140                 


Gly Pro Ala Val Thr Val Asp Thr Ala Cys Ser Ser Ser Leu Val Ala 
145                 150                 155                 160 


Leu His Gln Ala Gly His Ala Leu Arg Gln Gly Glu Cys Ser Leu Ala 
                165                 170                 175     


Leu Val Gly Gly Val Thr Val Met Ala Thr Pro Asp Leu Phe Val Glu 
            180                 185                 190         


Phe Ala Arg Gln Gly Gly Leu Ala Ser Asp Gly Arg Cys Lys Ala Phe 
        195                 200                 205             


Gly Asp Thr Ala Asp Gly Thr Gly Trp Ala Glu Gly Val Gly Val Leu 
    210                 215                 220                 


Leu Val Glu Arg Leu Ser Asp Ala Gln Ala Lys Gly His Arg Val Leu 
225                 230                 235                 240 


Ala Val Val Arg Gly Ser Ala Val Asn Gln Asp Gly Ala Ser Asn Gly 
                245                 250                 255     


Leu Thr Ala Pro Asn Gly Pro Ser Gln Gln Arg Val Ile Gln Ala Ala 
            260                 265                 270         


Leu His Asn Ala Arg Leu Thr Pro Ala Asp Val Asp Val Val Glu Ala 
        275                 280                 285             


His Gly Thr Gly Thr Thr Leu Gly Asp Pro Ile Glu Ala Gln Ala Val 
    290                 295                 300                 


Ile Ala Ala Tyr Gly Gln Gly Arg Asp Glu Pro Leu Leu Leu Gly Ser 
305                 310                 315                 320 


Leu Lys Ser Asn Val Gly His Thr Gln Ala Ala Ala Gly Val Ser Gly 
                325                 330                 335     


Val Ile Lys Met Val Met Ala Leu Gln His Gly Val Val Pro Arg Thr 
            340                 345                 350         


Leu His Val Asp Glu Pro Ser Ser His Val Asp Trp Thr Ala Gly Ala 
        355                 360                 365             


Val Arg Leu Val Thr Glu Asn Gln Ser Trp Pro Asp Thr Gly Arg Pro 
    370                 375                 380                 


Arg Arg Ala Ala Val Ser Ala Phe Gly Val Ser Gly Thr Asn Ala His 
385                 390                 395                 400 


Val Ile Leu Glu Ser Ser Ala Ala Pro Ser Pro Thr Ile Pro Gln Pro 
                405                 410                 415     


Pro Ser Ala Glu Pro Met Pro Leu Val Ile Ser Ala Lys Thr Pro Ala 
            420                 425                 430         


Ala Leu Ala Asp Tyr Glu Gly Arg Leu Arg Ala Tyr Leu Thr Ala Pro 
        435                 440                 445             


Gly Val Asp Val Pro Ala Val Ala Ala Thr Leu Ala Val Thr Arg Ser 
    450                 455                 460                 


Leu Phe Glu His Arg Ala Val Leu Leu Gly Gly Asn Thr Val Thr Gly 
465                 470                 475                 480 


Thr Ala Val Ala Asp Pro Arg Val Val Phe Val Phe Pro Gly Gln Gly 
                485                 490                 495     


Trp Gln Trp Leu Gly Met Gly Ala Ala Leu Arg Gly Ser Ser Val Val 
            500                 505                 510         


Phe Ala Glu Arg Met Thr Glu Cys Ala Ala Ala Leu Ser Glu Phe Val 
        515                 520                 525             


Asp Trp Asp Leu Phe Ala Val Leu Asp Asp Pro Ala Val Val Asp Arg 
    530                 535                 540                 


Val Asp Val Val Gln Pro Ala Cys Trp Ala Val Met Val Ser Leu Ala 
545                 550                 555                 560 


Ala Val Trp Gln Ala Ala Gly Val His Pro Asp Ala Val Val Gly His 
                565                 570                 575     


Ser Gln Gly Glu Ile Ala Ala Ala Cys Val Ala Gly Ala Leu Ser Leu 
            580                 585                 590         


Arg Asp Ala Ala Arg Val Val Ala Leu Arg Ser Arg Leu Ile Gly Glu 
        595                 600                 605             


Arg Leu Gly Arg Gly Ala Met Ala Ser Val Ser Leu Pro Ala Asp Gln 
    610                 615                 620                 


Ile Val Leu Ala Asp Gly Val Trp Ile Ala Ala His Asn Gly Pro Ala 
625                 630                 635                 640 


Ser Thr Val Ile Ala Gly Gly Ala Gly Ala Val Asp Gln Met Val Gly 
                645                 650                 655     


Glu Arg Val Arg Arg Ile Ala Val Asp Tyr Ala Ser His Thr Pro Asp 
            660                 665                 670         


Val Glu Gln Ile Gln Thr Glu Leu Leu Asp Ile Thr Ala Asp Val Gly 
        675                 680                 685             


Ser Gln Ala Pro Val Val Pro Trp Phe Ser Thr Val Asp Gly Val Trp 
    690                 695                 700                 


Val Asp Gly Pro Leu Asp Arg Asp Tyr Trp Tyr Arg Asn Leu Arg Gln 
705                 710                 715                 720 


Pro Val Gly Phe His Pro Ala Val Glu Ala Leu Gln Ala Leu Gly Glu 
                725                 730                 735     


Thr Val Phe Val Glu Val Ser Ala Ser Pro Val Leu Leu Pro Ala Met 
            740                 745                 750         


Asp Asp Ala Val Thr Val Ala Thr Leu Arg Arg Asp Glu Gly Ser Ile 
        755                 760                 765             


Thr Arg Met His Thr Ala Leu Ala Glu Ala His Val Leu Gly Val Asn 
    770                 775                 780                 


Val Asp Trp Pro Thr Val Val Gly Asp Thr Asp Arg Arg Thr Leu Asp 
785                 790                 795                 800 


Leu Pro Thr Tyr Ala Phe Gln His His Arg Tyr Trp Ile Ser Ala Ala 
                805                 810                 815     


Ala Arg Leu Asp Gly Leu Thr Ala Ala Glu Lys His Ser Leu Leu Leu 
            820                 825                 830         


Asp Ile Val Leu Ala Asn Ala Ala Thr Val Leu Gly His His Thr Val 
        835                 840                 845             


Asp Thr Ile Ala Pro Asp Lys Pro Phe Lys Asp Leu Gly Ile Asp Ser 
    850                 855                 860                 


Leu Thr Ala Val Glu Leu Arg Asn Gly Leu Ala Lys Ala Thr Gly Leu 
865                 870                 875                 880 


Arg Leu Pro Ala Thr Leu Val Phe Asp Tyr Pro Thr Pro Asp Met Ala 
                885                 890                 895     


Ala Ala Arg Leu 
            900 


<210>  144
<211>  873
<212>  PRT
<213>  Actinoplanes sp.

<400>  144

Glu Pro Leu Ala Ile Val Gly Met Ala Cys Arg Leu Pro Gly Gly Val 
1               5                   10                  15      


Ser Ser Pro Glu Asp Leu Trp Arg Leu Val Glu Ser Gly Thr Asp Ala 
            20                  25                  30          


Ile Ser Asp Phe Pro Thr Asp Arg Gly Trp Ala Asp Ala Ala Gly Ala 
        35                  40                  45              


Pro Tyr Ser Pro Gln Gly Gly Phe Val Asp Ala Ala Ala Asp Phe Asp 
    50                  55                  60                  


Ala Ala Phe Phe Gly Ile Ser Pro Arg Glu Ala Leu Ala Met Asp Pro 
65                  70                  75                  80  


Gln Gln Arg Leu Val Leu Glu Ala Ser Trp Glu Ala Phe Glu Arg Ala 
                85                  90                  95      


Gly Ile Glu Pro Gly Thr Val Arg Gly Ser Asp Thr Gly Val Phe Met 
            100                 105                 110         


Gly Ala Tyr Pro Gly Gly Tyr Gly Ile Gly Ala Asp Gln Ala Gly Phe 
        115                 120                 125             


Gly Thr Thr Ala Gly Ala Gly Ser Val Leu Ser Gly Arg Val Ser Tyr 
    130                 135                 140                 


Phe Phe Gly Leu Glu Gly Pro Ala Val Thr Val Asp Thr Ala Cys Ser 
145                 150                 155                 160 


Ser Ser Leu Val Ala Leu His Gln Ala Gly His Ala Leu Arg Gln Gly 
                165                 170                 175     


Glu Cys Ser Leu Ala Leu Val Gly Gly Val Thr Val Met Gly Thr Pro 
            180                 185                 190         


Asp Ile Phe Ala Glu Phe Ser Arg Gln Gly Gly Leu Ala Ser Asp Gly 
        195                 200                 205             


Arg Cys Lys Ala Phe Gly Asp Asp Ala Asp Gly Thr Gly Trp Gly Glu 
    210                 215                 220                 


Gly Val Gly Ile Leu Leu Val Glu Arg Leu Ser Asp Ala Gln Arg His 
225                 230                 235                 240 


Ser His Arg Val Leu Ala Val Val Arg Gly Ser Ala Val Asn Gln Asp 
                245                 250                 255     


Gly Ala Ser Asn Gly Leu Thr Ala Pro Asn Gly Pro Ser Gln Gln Arg 
            260                 265                 270         


Val Ile Gln Ala Ala Leu Ala His Ala Gly Leu Ala Pro His Glu Val 
        275                 280                 285             


Asp Val Val Glu Ala His Gly Thr Gly Thr Thr Leu Gly Asp Pro Ile 
    290                 295                 300                 


Glu Ala Gln Ala Val Ile Ala Thr Tyr Gly Gln Asp Arg Asp Glu Pro 
305                 310                 315                 320 


Leu Leu Leu Gly Ser Val Lys Ser Asn Val Gly His Thr Gln Ala Ala 
                325                 330                 335     


Ala Gly Val Ala Gly Val Ile Lys Met Val Met Ala Leu Arg His Gly 
            340                 345                 350         


Val Val Pro Arg Thr Leu His Ala Asp Gln Pro Ser Arg His Val Asp 
        355                 360                 365             


Trp Thr Ala Gly Ala Val Arg Leu Ala Thr Glu Asn Gln Pro Trp Pro 
    370                 375                 380                 


Ala Ile Asp Arg Pro Arg Arg Ala Gly Val Ser Ser Phe Gly Ile Ser 
385                 390                 395                 400 


Gly Thr Asn Ala His Val Ile Leu Glu Gly Val Ala Glu Glu Pro Ala 
                405                 410                 415     


Gln Ser Glu Glu Ser Ser Pro Leu Met Pro Leu Val Ile Ser Ala Lys 
            420                 425                 430         


Thr Pro Ala Ala Leu Thr Arg Leu Glu Glu Arg Leu Arg Ala Tyr Leu 
        435                 440                 445             


Ala Ala Lys Pro Glu Thr Ser Leu Gly Ala Val Ala Ser Thr Leu Ala 
    450                 455                 460                 


Glu Thr Arg Ser Leu Phe Glu His Arg Ala Val Leu Leu Asn Gly Asp 
465                 470                 475                 480 


Val Val Arg Gly Val Ala Glu Pro Asn Pro Arg Val Val Phe Val Phe 
                485                 490                 495     


Ser Gly Gln Gly Ser Gln Arg Ala Gly Met Gly Asp Glu Val Ala Ala 
            500                 505                 510         


Ala Phe Pro Val Phe Ala Lys Ile Arg Arg Gln Val Trp Asp Leu Leu 
        515                 520                 525             


Asp Val Pro Asp Leu Asp Val Asn Asp Thr Gly His Ala Gln Pro Ala 
    530                 535                 540                 


Leu Phe Ala Leu Gln Val Ala Leu Phe Gly Leu Leu Glu Ser Trp Gly 
545                 550                 555                 560 


Val Arg Pro Asp Ala Leu Ile Gly His Ser Ile Gly Glu Leu Ala Ala 
                565                 570                 575     


Gly Tyr Val Ser Gly Ile Trp Ser Leu Glu Asp Ala Cys Ala Leu Val 
            580                 585                 590         


Ser Ala Arg Ala Arg Leu Met Gln Ala Leu Pro Ala Gly Gly Ala Met 
        595                 600                 605             


Val Ala Val Pro Val Ser Glu Gln Gln Ala Arg Ala Val Leu Thr Asp 
    610                 615                 620                 


Gly Val Glu Ile Ala Ala Val Asn Gly Pro Ser Ser Val Val Leu Ser 
625                 630                 635                 640 


Gly Asp Glu Glu Ala Val Leu Arg Ala Ala Ala Gly Leu Gly Ser Arg 
                645                 650                 655     


Trp Lys Arg Leu Ala Thr Ser His Ala Phe His Ser Ala Arg Met Glu 
            660                 665                 670         


Pro Met Leu Asp Glu Phe Arg Val Val Ala Glu Gln Leu Ser Tyr Lys 
        675                 680                 685             


Thr Pro Arg Ile Pro Val Ala Val Gly Glu Gly Pro Glu Tyr Trp Val 
    690                 695                 700                 


Arg Gln Val Arg Glu Thr Val Arg Phe Gly Glu His Val Ala Ala His 
705                 710                 715                 720 


Asp Gly Ala Val Phe Val Glu Leu Gly Pro Asp Gly Ser Leu Ala Arg 
                725                 730                 735     


Leu Ile Asp Gly Ile Ala Thr Leu Asp Arg Asp Asp Glu Pro Arg Ala 
            740                 745                 750         


Ala Leu Thr Ala Leu Ala Glu Leu His Val Arg Gly Val Asp Val Asp 
        755                 760                 765             


Trp Pro Leu Thr Ser Gly Arg Arg Val Asp Leu Pro Thr Tyr Ala Phe 
    770                 775                 780                 


Gln Arg Gln Arg Tyr Trp Thr Thr Ala Gly Leu Thr Arg Ala Glu Arg 
785                 790                 795                 800 


Glu Gln Ala Leu Leu Lys Leu Val Arg Asp Thr Ala Ala Val Val Leu 
                805                 810                 815     


Gly Tyr Gly Asp Gly Asn Ala Val Pro Val Thr Ala Ala Phe Lys Asp 
            820                 825                 830         


Leu Gly Val Asp Ser Leu Thr Ala Val Glu Leu Arg Asn Gly Leu Ala 
        835                 840                 845             


Glu Ala Ile Gly Leu Arg Leu Pro Ala Thr Leu Val Phe Asp Tyr Pro 
    850                 855                 860                 


Thr Pro Ala Thr Leu Ala Val Arg Leu 
865                 870             


<210>  145
<211>  871
<212>  PRT
<213>  Actinoplanes sp.

<400>  145

Glu Pro Leu Ala Ile Val Gly Met Ala Cys Arg Leu Pro Gly Gly Val 
1               5                   10                  15      


Glu Ser Pro Asp Asp Leu Trp Arg Leu Val Glu Ser Gly Thr Asp Ala 
            20                  25                  30          


Ile Thr Gly Phe Pro Thr Asp Arg Gly Trp Pro Asp Val Thr Gly Thr 
        35                  40                  45              


Ser His Ser Gln His Gly Gly Phe Leu His Thr Ala Ala Asp Phe Asp 
    50                  55                  60                  


Ala Ala Phe Phe Gly Ile Ser Pro Arg Glu Ala Leu Ala Met Asp Pro 
65                  70                  75                  80  


Gln Gln Arg Leu Ile Leu Glu Ala Ser Trp Glu Ala Phe Glu Arg Ala 
                85                  90                  95      


Gly Ile Asn Pro Ala Asp Ala His Gly Thr Asp Thr Gly Val Phe Met 
            100                 105                 110         


Gly Ala Phe Ser Ala Gly Tyr Asp Ala Asp Arg Asp Asp Ser Pro Ala 
        115                 120                 125             


Thr Ala Gly Ala Val Ser Val Leu Ser Gly Arg Ile Ser Tyr Phe Phe 
    130                 135                 140                 


Gly Leu Glu Gly Pro Ala Met Thr Val Asp Thr Ala Cys Ser Ser Ser 
145                 150                 155                 160 


Leu Val Ala Leu His Gln Ala Gly Tyr Ser Leu Arg Gln Gly Glu Cys 
                165                 170                 175     


Ser Met Ala Leu Val Gly Gly Val Thr Val Met Ala Thr Pro Arg Thr 
            180                 185                 190         


Phe Val Glu Phe Ser Arg Gln Gly Gly Leu Ala Ser Asp Gly Arg Cys 
        195                 200                 205             


Lys Ala Phe Gly Asp Thr Ala Asp Gly Thr Gly Trp Ser Glu Gly Val 
    210                 215                 220                 


Gly Val Leu Val Val Glu Arg Leu Ser Asp Ala Arg Ala Lys Gly His 
225                 230                 235                 240 


Arg Val Leu Ala Val Val Arg Ser Ser Ala Val Asn Gln Asp Gly Ala 
                245                 250                 255     


Ser Asn Gly Leu Thr Ala Pro Asn Gly Pro Ser Gln Gln Arg Val Ile 
            260                 265                 270         


Gln Ala Ala Leu His Asn Ala His Leu Thr Pro Ala Asp Val Asp Val 
        275                 280                 285             


Val Glu Ala His Gly Thr Gly Thr Thr Leu Gly Asp Pro Ile Glu Ala 
    290                 295                 300                 


Gln Ala Val Ile Ala Ala Tyr Gly Gln Asp Arg Asp Glu Pro Leu Leu 
305                 310                 315                 320 


Leu Gly Ser Ile Lys Ser Asn Val Gly His Thr Gln Ala Ala Ala Gly 
                325                 330                 335     


Val Ser Gly Val Ile Lys Met Val Met Ala Leu Arg His Gly Val Val 
            340                 345                 350         


Pro Arg Thr Leu His Ala Asp Gln Pro Ser Arg His Val Asp Trp Asn 
        355                 360                 365             


Ala Gly Ala Val Gln Leu Val Thr Glu Asn Gln Ser Trp Pro Glu Thr 
    370                 375                 380                 


Gly Arg Pro Arg Arg Ala Ala Val Ser Ser Phe Gly Ile Ser Gly Thr 
385                 390                 395                 400 


Asn Ala His Val Ile Leu Glu Gly Val Pro Glu Gln Pro Ala Gln Pro 
                405                 410                 415     


Glu Pro Pro Ser Glu Arg Val Pro Leu Met Ile Ser Ala Lys Ser Thr 
            420                 425                 430         


Ser Ala Leu Ser Gln Leu Glu Asp Arg Leu Arg Ala Tyr Leu Ala Ala 
        435                 440                 445             


Arg Pro Glu Ala Ser Leu Gly Ala Val Ala Ser Thr Leu Ala Thr Arg 
    450                 455                 460                 


Ser Leu Phe Glu His Arg Ala Val Leu Leu Asp Gly Gln Val Val Lys 
465                 470                 475                 480 


Gly Val Ala Glu Pro Asn Pro Arg Val Val Phe Val Phe Ser Gly Gln 
                485                 490                 495     


Gly Ser Gln Arg Ala Gly Met Gly Asp Glu Leu Ala Ala Ala Phe Pro 
            500                 505                 510         


Val Phe Ala Lys Ile Arg Gly Gln Val Trp Asp Leu Leu Asp Val Pro 
        515                 520                 525             


Asp Leu Asp Val Asn Asp Thr Gly His Ala Gln Pro Ala Leu Phe Ala 
    530                 535                 540                 


Leu Gln Val Ala Leu Phe Gly Leu Leu Glu Ser Trp Gly Val Arg Pro 
545                 550                 555                 560 


Asp Ala Leu Ile Gly His Ser Ile Gly Glu Leu Ala Ala Gly Tyr Val 
                565                 570                 575     


Ser Gly Ile Trp Ser Leu Glu Asp Ala Cys Thr Leu Val Ser Ala Arg 
            580                 585                 590         


Ala Arg Leu Met Gln Ala Leu Pro Ala Gly Gly Ala Met Val Ala Val 
        595                 600                 605             


Pro Val Ser Glu Gln Gln Ala Arg Ala Val Leu Thr Gly Gly Val Glu 
    610                 615                 620                 


Ile Ala Ala Val Asn Gly Pro Ser Ser Val Val Leu Ser Gly Asp Glu 
625                 630                 635                 640 


Gly Ala Val Leu Arg Ala Ala Ala Ala Leu Gly Gly Arg Trp Lys Arg 
                645                 650                 655     


Leu Ala Thr Ser His Ala Phe His Ser Ala Arg Met Glu Pro Met Leu 
            660                 665                 670         


Asp Glu Phe Arg Ala Ala Ala Glu Gln Leu Thr Tyr Gln Thr Pro Arg 
        675                 680                 685             


Ile Pro Met Val Val Gly Asp Gly Pro Asp Tyr Trp Val Arg Gln Val 
    690                 695                 700                 


Arg Glu Thr Val Arg Phe Gly Glu Gln Val Ala Ala His Asp Gly Ala 
705                 710                 715                 720 


Val Phe Val Glu Leu Gly Pro Asp Arg Ser Leu Ala Arg Leu Ile Asp 
                725                 730                 735     


Gly Ile Ala Thr Leu Asp Arg Asp Asp Glu Pro Arg Ala Ala Leu Thr 
            740                 745                 750         


Ala Leu Ala Glu Leu His Val Arg Gly Val Asp Val Asp Trp Pro His 
        755                 760                 765             


Asp Gly Gln Leu Val Asp Leu Pro Thr Tyr Ala Phe Gln Arg Glu Arg 
    770                 775                 780                 


Tyr Trp Ala Thr Ala Leu Ala Ala Leu Pro Leu Ala Glu Arg Glu Gln 
785                 790                 795                 800 


Ala Leu Leu Ala Val Val Ser Asp Asn Ala Ala Val Val Leu Gly Tyr 
                805                 810                 815     


Ala Glu Gly Arg Asp Val Thr Gln Thr Ala Ala Phe Lys Asp Leu Gly 
            820                 825                 830         


Val Asp Ser Leu Thr Ala Val Glu Leu Arg Asn Thr Leu Ala Lys Ala 
        835                 840                 845             


Thr Gly Leu Arg Leu Pro Ala Thr Ile Val Phe Asp Tyr Pro Thr Pro 
    850                 855                 860                 


Asp Thr Leu Ala Ala Arg Leu 
865                 870     


<210>  146
<211>  878
<212>  PRT
<213>  Actinoplanes sp.

<400>  146

Glu Pro Leu Ala Ile Val Gly Met Ala Cys Arg Leu Pro Gly Gly Val 
1               5                   10                  15      


Ser Ser Pro Glu Asp Leu Trp Arg Leu Val Glu Ser Gly Thr Asp Ala 
            20                  25                  30          


Ile Ser Arg Phe Pro Asp Asp Arg Gly Trp Asp Val Glu Gly Leu Phe 
        35                  40                  45              


Asp Pro Asp Pro Asp Ala Pro Gly Lys Ser Tyr Ser Val Glu Gly Gly 
    50                  55                  60                  


Phe Leu Asp Ala Val Ala Asp Phe Asp Ala Ala Phe Phe Gly Ile Ser 
65                  70                  75                  80  


Pro Arg Glu Ala Leu Ala Met Asp Pro Gln Gln Arg Leu Val Leu Glu 
                85                  90                  95      


Ala Ser Trp Glu Ala Phe Glu Arg Ala Gly Ile Glu Pro Gly Ser Val 
            100                 105                 110         


Arg Gly Ser Asp Thr Gly Val Phe Met Gly Ala Tyr Ser Gly Gly Tyr 
        115                 120                 125             


Gly Ile Gly Ala Asp Leu Pro Gly Leu Gly Val Thr Ala Gly Ala Val 
    130                 135                 140                 


Ser Val Val Ser Gly Arg Val Ser Tyr Phe Phe Gly Leu Glu Gly Pro 
145                 150                 155                 160 


Ala Val Thr Val Asp Thr Ala Cys Ser Ser Ser Leu Val Ala Leu His 
                165                 170                 175     


Gln Ala Gly His Ala Leu Arg Arg Arg Glu Cys Ser Leu Ala Leu Val 
            180                 185                 190         


Gly Gly Val Thr Val Met Ala Thr Pro Phe Gly Phe Val Glu Phe Ser 
        195                 200                 205             


Arg Gln Arg Gly Leu Ala Ala Asp Gly Arg Cys Lys Ala Phe Ala Asp 
    210                 215                 220                 


Thr Ala Asp Gly Thr Ser Trp Ser Glu Gly Val Gly Val Leu Val Val 
225                 230                 235                 240 


Glu Arg Leu Ser Asp Ala Arg Ala Asn Gly His Gln Val Leu Ala Val 
                245                 250                 255     


Val Arg Gly Ser Ala Val Asn Gln Asp Gly Ala Ser Asn Gly Leu Thr 
            260                 265                 270         


Ala Pro Asn Gly Pro Ser Gln Gln Arg Val Ile Gln Ala Ala Leu Ala 
        275                 280                 285             


His Ala Asp Leu Ala Pro His Glu Val Asp Val Val Glu Ala His Gly 
    290                 295                 300                 


Thr Gly Thr Arg Leu Gly Asp Pro Ile Glu Ala Gln Ala Val Ile Ala 
305                 310                 315                 320 


Thr Tyr Gly Gln Gly Arg Asp Glu Pro Leu Leu Leu Gly Ser Ile Lys 
                325                 330                 335     


Ser Asn Val Gly His Thr Gln Ala Ala Ala Gly Val Ser Gly Val Ile 
            340                 345                 350         


Lys Met Val Met Ala Leu Arg His Gly Val Val Pro Gln Thr Leu His 
        355                 360                 365             


Val Asp Glu Pro Thr Gln His Val Asp Trp Thr Ala Gly Ala Val Arg 
    370                 375                 380                 


Leu Ala Thr Glu Asn Gln Pro Trp Pro Asp Thr Gly Arg Pro Arg Arg 
385                 390                 395                 400 


Ala Gly Val Ser Ser Phe Gly Val Ser Gly Thr Asn Ala His Val Ile 
                405                 410                 415     


Leu Glu Gly Val Ala Glu Glu Pro Ala Gln Ser Glu Glu Ser Ser Glu 
            420                 425                 430         


Leu Val Pro Leu Val Ile Ser Ala Lys Thr Pro Ala Ala Leu Thr Arg 
        435                 440                 445             


Leu Glu Glu Arg Leu Arg Ala Tyr Leu Ser Ala Glu Ser Asn Leu Ser 
    450                 455                 460                 


Ala Val Ala Ser Thr Leu Ala Glu Thr Arg Ser Leu Phe Glu His Arg 
465                 470                 475                 480 


Ala Val Leu Leu Gly Asp Asp Thr Ile Lys Gly Thr Ala Gln Pro Asn 
                485                 490                 495     


Pro Arg Val Val Phe Val Phe Ser Gly Gln Gly Ser Gln Arg Ala Gly 
            500                 505                 510         


Met Gly Asp Glu Leu Ala Ala Ala Phe Pro Val Phe Ala Arg Ile Arg 
        515                 520                 525             


Arg Gln Val Trp Asp Leu Leu Asp Val Pro Asp Val Ser Val Asp Asp 
    530                 535                 540                 


Thr Gly Phe Ala Gln Pro Ala Leu Phe Ala Leu Gln Val Ala Leu Phe 
545                 550                 555                 560 


Gly Leu Leu Glu Ser Trp Gly Val Arg Pro Asp Ala Leu Ile Gly His 
                565                 570                 575     


Ser Ile Gly Glu Leu Ala Ala Gly Tyr Val Ser Gly Ile Trp Ser Leu 
            580                 585                 590         


Glu Asp Ala Cys Thr Leu Val Ser Ala Arg Ala Arg Leu Met Gln Ala 
        595                 600                 605             


Leu Pro Ala Gly Gly Ala Met Val Ala Val Pro Val Ser Glu Gln Gln 
    610                 615                 620                 


Ala Arg Ala Val Leu Thr Gly Gly Val Glu Ile Ala Ala Val Asn Gly 
625                 630                 635                 640 


Pro Ser Ser Val Val Leu Ser Gly Asp Glu Glu Ala Val Leu Arg Ala 
                645                 650                 655     


Ala Ala Ala Leu Gly Gly Arg Ser Lys Arg Leu Val Thr Ser His Ala 
            660                 665                 670         


Phe His Ser Ala Arg Met Glu Pro Met Leu Asp Glu Phe Gln Ala Val 
        675                 680                 685             


Ala Glu Gln Leu Thr Tyr Gln Ala Pro Arg Ile Pro Met Ala Val Gly 
    690                 695                 700                 


Asp Gly Pro Asp Tyr Trp Val Arg Gln Val Arg Glu Thr Val Arg Phe 
705                 710                 715                 720 


Gly Asp Gln Val Ala Ala Gln Asp Gly Ala Val Phe Val Glu Leu Gly 
                725                 730                 735     


Pro Asp Arg Ser Leu Ala Arg Leu Ile Asp Gly Ile Ala Thr Leu Asp 
            740                 745                 750         


Arg Asp Asp Glu Pro Arg Ala Ala Leu Thr Ala Leu Ala Glu Leu His 
        755                 760                 765             


Val Arg Gly Val Asp Val Asp Trp Pro Leu Thr Ser Gly Arg Arg Val 
    770                 775                 780                 


Asp Leu Pro Thr Tyr Ala Phe Gln Arg Gln Arg Tyr Trp Ile Asp Ser 
785                 790                 795                 800 


Ala Leu Thr Pro Ala Glu Arg Glu Gln Ala Leu Leu Lys Val Val Arg 
                805                 810                 815     


Asp Ser Ala Ala Val Val Leu Gly Tyr Thr Asp Ala Val Pro Val Ser 
            820                 825                 830         


Gly Ser Phe Lys Asp Leu Gly Ile Asp Ser Leu Thr Ala Val Glu Leu 
        835                 840                 845             


Arg Asn Ser Leu Ala Lys Val Thr Gly Leu Arg Leu Pro Ala Thr Leu 
    850                 855                 860                 


Val Phe Asp Tyr Pro Thr Pro Ala Thr Leu Ala Ala Arg Leu 
865                 870                 875             


<210>  147
<211>  904
<212>  PRT
<213>  Actinoplanes sp.

<400>  147

Glu Pro Leu Ala Ile Val Gly Met Ala Cys Arg Leu Pro Gly Gly Val 
1               5                   10                  15      


Glu Ser Pro Asp Asp Leu Trp Arg Leu Val Glu Ser Gly Thr Asp Ala 
            20                  25                  30          


Ile Thr Gly Phe Pro Thr Asp Arg Gly Trp Pro Asp Val Thr Gly Thr 
        35                  40                  45              


Ser His Ser Gln His Gly Gly Phe Leu His Thr Ala Ala Asp Phe Asp 
    50                  55                  60                  


Ala Ala Phe Phe Gly Ile Ser Pro Arg Glu Ala Leu Ala Met Asp Pro 
65                  70                  75                  80  


Gln Gln Arg Leu Ile Leu Glu Ala Ser Trp Glu Ala Phe Glu Arg Ala 
                85                  90                  95      


Gly Ile Asn Pro Ala Asp Ala His Gly Thr Asp Thr Gly Val Phe Met 
            100                 105                 110         


Gly Ala Tyr Ser Gly Gly Tyr Gly Ile Gly Ala Asp Leu Ala Gly Phe 
        115                 120                 125             


Gly Ala Thr Ser Gly Ala Thr Ser Val Leu Ser Gly Arg Val Ser Tyr 
    130                 135                 140                 


Phe Phe Gly Leu Glu Gly Pro Ala Ile Thr Val Asp Thr Ala Cys Ser 
145                 150                 155                 160 


Ser Ser Leu Val Ala Leu His Gln Ala Gly His Ala Leu Arg Gln Gly 
                165                 170                 175     


Glu Cys Ala Met Ala Leu Val Gly Gly Val Thr Val Met Ala Thr Pro 
            180                 185                 190         


Asp Ile Phe Val Glu Phe Ser Arg Gln Arg Gly Leu Ala Ala Asp Gly 
        195                 200                 205             


Arg Cys Lys Ala Phe Ala Asp Ala Ala Asp Gly Thr Gly Trp Ala Glu 
    210                 215                 220                 


Gly Val Gly Val Leu Leu Val Glu Arg Leu Ser Asp Ala Glu Arg Asn 
225                 230                 235                 240 


Gly His Arg Val Leu Ala Val Val Arg Ser Ser Ala Val Asn Gln Asp 
                245                 250                 255     


Gly Ala Ser Asn Gly Leu Thr Ala Pro Asn Gly Pro Ser Gln Gln Arg 
            260                 265                 270         


Val Ile Gln Ala Ala Leu His Asn Ala Arg Leu Thr Pro Ala Asp Val 
        275                 280                 285             


Asp Val Val Glu Ala His Gly Thr Gly Thr Thr Leu Gly Asp Pro Ile 
    290                 295                 300                 


Glu Ala Gln Ala Val Ile Ala Ala Tyr Gly Gln Gly Arg Asp Glu Pro 
305                 310                 315                 320 


Leu Leu Leu Gly Ser Leu Lys Ser Asn Val Gly His Thr Gln Ala Ala 
                325                 330                 335     


Ala Gly Val Ser Gly Val Ile Lys Met Val Met Ala Leu Gln His Gly 
            340                 345                 350         


Val Val Pro Arg Thr Leu His Val Asp Glu Pro Ser Ser His Val Asp 
        355                 360                 365             


Trp Thr Ala Gly Ala Val Arg Leu Ala Thr Glu Asn Gln Ser Trp Pro 
    370                 375                 380                 


Asp Thr Gly Arg Pro Arg Arg Ala Ala Val Ser Ala Phe Gly Val Ser 
385                 390                 395                 400 


Gly Thr Asn Ala His Val Ile Leu Glu Ser Ser Ala Ala Pro Ser Pro 
                405                 410                 415     


Thr Ile Pro Gln Pro Pro Ser Ala Glu Pro Met Pro Leu Val Ile Ser 
            420                 425                 430         


Ala Lys Thr Pro Ala Ala Leu Ala Asp Tyr Glu Asp Arg Leu Arg Ala 
        435                 440                 445             


Tyr Leu Thr Asn Pro Gly Val Asp Val Pro Ala Val Ala Ala Thr Leu 
    450                 455                 460                 


Ala Met Thr Arg Ser Leu Phe Glu His Arg Ala Val Leu Leu Gly Gly 
465                 470                 475                 480 


Asn Thr Val Thr Gly Thr Ala Val Ala Asp Pro Arg Val Val Phe Val 
                485                 490                 495     


Phe Pro Gly Gln Gly Trp Gln Trp Leu Gly Met Gly Ala Ala Leu Arg 
            500                 505                 510         


Gly Ser Ser Val Val Phe Ala Glu Arg Met Thr Glu Cys Ala Ala Ala 
        515                 520                 525             


Leu Ser Glu Phe Val Asp Trp Asp Leu Phe Ala Val Leu Asp Asp Pro 
    530                 535                 540                 


Ala Val Val Asp Arg Val Asp Val Val Gln Pro Ala Cys Trp Ala Val 
545                 550                 555                 560 


Met Val Ser Leu Ala Ala Val Trp Gln Ala Ala Gly Val His Pro Asp 
                565                 570                 575     


Ala Val Leu Gly His Ser Gln Gly Glu Ile Ala Ala Ala Cys Val Ala 
            580                 585                 590         


Gly Ala Ile Ser Leu Gln Asp Ala Ala Arg Val Val Ala Leu Arg Ser 
        595                 600                 605             


Gln Ala Ile Ser Gly Leu Ser Gly Lys Gly Ala Met Ala Ser Ile Ala 
    610                 615                 620                 


Leu Pro Ala Asp Gln Ile Ala Leu Pro Asp Gly Ala Trp Ile Ala Ala 
625                 630                 635                 640 


His Asn Gly Pro Ala Ser Thr Val Val Ala Gly Ser Pro Asp Ala Val 
                645                 650                 655     


Glu Gln Met Leu Gly Asp Arg Val Arg Lys Ile Ala Val Asp Tyr Ala 
            660                 665                 670         


Ser His Thr Pro His Val Glu Gln Ile Gln Thr Glu Leu Leu Asp Ile 
        675                 680                 685             


Thr Ala Gly Ile Gly Ser Arg Thr Pro Thr Ile Pro Trp Phe Ser Thr 
    690                 695                 700                 


Val Asp Gly Met Trp Val Asp Gly Pro Leu Asp Arg Asp Tyr Trp Tyr 
705                 710                 715                 720 


Arg Asn Leu Arg Gln Pro Val Gly Phe His Pro Ala Val Glu Ala Leu 
                725                 730                 735     


Gln Ala Leu Gly Glu Thr Val Phe Val Glu Val Ser Ala Ser Pro Val 
            740                 745                 750         


Leu Leu Pro Ala Met Asp Asp Ala Val Thr Val Ala Thr Leu Arg Arg 
        755                 760                 765             


Asp Glu Gly Ser Ile Thr Arg Met His Thr Ala Leu Ala Glu Ala His 
    770                 775                 780                 


Val Leu Gly Val Asn Val Asp Trp Pro Thr Leu Leu Gly Asp Thr Gly 
785                 790                 795                 800 


Arg Arg Thr Leu Asp Leu Pro Thr Tyr Ala Phe Gln His His Arg Tyr 
                805                 810                 815     


Trp Ile Asn Gly Ser Arg Leu Ile Gly Arg Thr Thr Ala Glu Gln His 
            820                 825                 830         


Arg Leu Met Leu Ala Phe Val Leu Gly Asn Val Ala Ser Val Leu Gly 
        835                 840                 845             


His Gly Ser Ala Asp Ala Ile Ala Ala Asp Lys Pro Phe Lys Asp Leu 
    850                 855                 860                 


Gly Met Asp Ser Leu Thr Ser Val Glu Leu Arg Asn Ser Leu Ala Lys 
865                 870                 875                 880 


Ala Thr Glu Leu Arg Leu Pro Ala Thr Ile Val Phe Asp His Pro Thr 
                885                 890                 895     


Ala Asp Ala Leu Ala Ala His Leu 
            900                 


<210>  148
<211>  947
<212>  PRT
<213>  Actinoplanes sp.

<400>  148

Glu Pro Ile Ala Ile Val Ser Met Ala Cys Arg Val Pro Gly Gly Val 
1               5                   10                  15      


Thr Ser Pro Glu Gly Leu Trp Arg Leu Val Glu Ser Gly Thr Asp Ala 
            20                  25                  30          


Ile Ser Ala Phe Pro Gly Asp Arg Gly Trp Asp Ile Ala Asn Leu Tyr 
        35                  40                  45              


Ser Pro Asp Pro Asp Ala Pro Gly Lys Ser Tyr Ser Val Gln Gly Gly 
    50                  55                  60                  


Phe Leu Asp Gly Ala Ala Ala Phe Asp Ala Ser Phe Phe Gly Ile Ser 
65                  70                  75                  80  


Pro Arg Glu Ala Leu Gly Met Asp Pro Gln Gln Arg Val Leu Leu Glu 
                85                  90                  95      


Thr Ala Trp Glu Ala Val Glu Arg Ala Arg Ile Asp Pro Arg Ser Leu 
            100                 105                 110         


Arg Gly Arg Asp Val Gly Val Tyr Val Gly Gly Ala Ala Gln Gly Tyr 
        115                 120                 125             


Gly Leu Gly Ala Ala Glu Ala His Arg Asp Asn Leu Ile Thr Gly Gly 
    130                 135                 140                 


Ser Ile Ser Leu Leu Ser Gly Arg Leu Ser Tyr Ala Leu Gly Leu Glu 
145                 150                 155                 160 


Gly Pro Gly Leu Thr Val Asp Thr Ala Cys Ser Ser Ser Leu Val Ala 
                165                 170                 175     


Leu His Leu Ala Ala Gln Ala Leu Arg Gln Gly Glu Cys Ser Leu Ala 
            180                 185                 190         


Leu Val Ser Gly Val Ser Val Met Pro Thr Pro Asp Val Phe Val Glu 
        195                 200                 205             


Phe Ser Arg Gln Arg Gly Leu Ala Ser Asp Gly Arg Cys Lys Ser Phe 
    210                 215                 220                 


Ala Ala Ser Ala Asp Gly Thr Ser Trp Ser Glu Gly Val Gly Val Leu 
225                 230                 235                 240 


Val Leu Glu Arg Leu Ser Glu Ala Arg Arg Leu Gly His Gln Val Leu 
                245                 250                 255     


Ala Val Val Arg Gly Thr Ala Val Asn Ser Asp Gly Ala Ser Asn Gly 
            260                 265                 270         


Leu Thr Ala Pro Asn Gly Ala Ala Gln Gln Arg Val Ile Arg Gln Ala 
        275                 280                 285             


Leu Ala Asn Ala Gly Leu Ser Thr Ala Asp Val Asp Ala Val Glu Ala 
    290                 295                 300                 


His Gly Thr Gly Thr Thr Leu Gly Asp Pro Ile Glu Ala Glu Ala Ile 
305                 310                 315                 320 


Leu Ala Thr Tyr Gly Lys Asp Arg Ser Thr Pro Val Trp Leu Gly Ser 
                325                 330                 335     


Leu Lys Ser Asn Ile Gly His Thr Met Ala Ala Ser Gly Val Leu Gly 
            340                 345                 350         


Val Ile Lys Met Val Glu Ala Met Arg His Gly Val Leu Pro Arg Thr 
        355                 360                 365             


Leu His Val Asp Glu Pro Ser Pro His Val Asp Trp Ala Ala Gly Glu 
    370                 375                 380                 


Val Ala Leu Leu Thr Glu Asn Gln Thr Trp Pro Gly Asp Val Arg Pro 
385                 390                 395                 400 


Arg Arg Ala Gly Val Ser Ser Phe Gly Leu Ser Gly Thr Asn Ala His 
                405                 410                 415     


Val Val Leu Glu Gln Asp Glu Ala Pro Ala Ala Pro Val Thr Thr Lys 
            420                 425                 430         


Glu Ser Gly Pro Leu Pro Trp Val Leu Ser Ala Gln Ser Pro Lys Ala 
        435                 440                 445             


Leu Arg Gln Arg Ala Gly Gln Leu Ala Thr Ala Leu Ala Glu Asp Ser 
    450                 455                 460                 


Thr Trp His Pro Leu Asp Val Ala Tyr Ser Leu Ala Thr Thr Arg Ser 
465                 470                 475                 480 


Asp Phe Ala His Arg Ala Val Val Val Gly Ala Asp Arg Glu Leu Leu 
                485                 490                 495     


Arg Thr Leu Gly Lys Val Ala Asp Gly Ala Gly Trp Pro Gly Leu Thr 
            500                 505                 510         


Thr Gly Thr Ala Lys Ala Arg Arg Val Ala Phe Leu Phe Asp Gly Gln 
        515                 520                 525             


Gly Thr Gln Arg Leu Thr Met Gly Gln Gly Leu Tyr Gly Ser Phe Pro 
    530                 535                 540                 


Ala Phe Ala Arg Ala Trp Asp Thr Val Ser Ala Glu Phe Gly Lys His 
545                 550                 555                 560 


Leu Asp His Pro Leu Ala Asp Val Tyr Phe Asp Gly Ser Gly Gly Ala 
                565                 570                 575     


Ala Thr Ala Asp Leu Val Asp Asp Pro Leu Tyr Ala Gln Ala Gly Ile 
            580                 585                 590         


Phe Ala Val Glu Val Ala Leu Val Glu Leu Leu Ala Glu Trp Gly Val 
        595                 600                 605             


Arg Pro Asp Val Val Thr Gly His Ser Ile Gly Glu Ala Ala Ala Ala 
    610                 615                 620                 


Tyr Thr Ala Gly Met Leu Ser Leu Ser Asp Val Thr Thr Leu Ile Val 
625                 630                 635                 640 


Ala Arg Gly Ala Ala Leu Arg Ser Ala Pro Pro Gly Ala Met Leu Ala 
                645                 650                 655     


Leu Arg Ala Gly Glu Gln Glu Val Arg Asn Phe Leu Asp Gly Thr Gly 
            660                 665                 670         


Ala Ala Leu Asp Leu Ala Ala Val Asn Gly Pro Ala Ala Val Val Val 
        675                 680                 685             


Ser Gly Ala Pro Asp Ala Val Thr Asp Phe Ala Ser Ala Trp Thr Ala 
    690                 695                 700                 


Ser Gly Arg Glu Ala Arg Arg Leu Lys Val Arg Arg Ala Phe His Ser 
705                 710                 715                 720 


Arg His Val Glu Gly Val Leu Asp Asp Phe Arg Thr Ala Leu Glu Ser 
                725                 730                 735     


Leu Ser Phe Arg Thr Pro Leu Leu Pro Val Val Ser Thr Val Thr Gly 
            740                 745                 750         


Arg Leu Ile Asp Pro Ala Glu Met Gly Thr Pro Glu Tyr Trp Leu Asp 
        755                 760                 765             


Gln Val Arg Gln Pro Val Arg Phe Gln Glu Ala Val Gln Glu Leu Ala 
    770                 775                 780                 


Gly Gln Gly Val Gly Thr Phe Val Glu Val Gly Pro Ser Gly Thr Leu 
785                 790                 795                 800 


Ala Ser Ala Gly Met Glu Cys Leu Asp Gly Asp Ala Ser Phe His Ala 
                805                 810                 815     


Leu Leu Arg Pro Arg Ser Ala Glu Asp Val Gly Val Leu Thr Ala Leu 
            820                 825                 830         


Ala Glu Leu His Ala Gly Gly Thr Ala Ile Asp Trp Pro Thr Val Leu 
        835                 840                 845             


Ala Gly Gly Arg Pro Met Asp Leu Pro Val Tyr Pro Phe Gln His Gln 
    850                 855                 860                 


Ser Tyr Trp Leu Val Ser Thr Asp Glu Pro Arg Thr Thr Leu Glu Leu 
865                 870                 875                 880 


Val His Leu Glu Val Ala Arg Val Leu Gly Ile Thr Asp Pro Asp Thr 
                885                 890                 895     


Val Leu Asp Asp Ala Ser Phe Leu Glu Leu Gly Phe Asp Ser Leu Gly 
            900                 905                 910         


Gly Val Arg Leu Arg Asn Arg Leu Ala Gln Val Thr Gly Leu Thr Leu 
        915                 920                 925             


Pro Pro Thr Leu Leu Phe Asp His Val Thr Pro Ala Ala Leu Ala Ala 
    930                 935                 940                 


Glu Leu Asp 
945         


<210>  149
<211>  899
<212>  PRT
<213>  Streptomyces rapamycinicus

<400>  149

Glu Pro Leu Ala Ile Val Gly Met Ala Cys Arg Leu Pro Gly Gly Val 
1               5                   10                  15      


Ser Ser Pro Glu Asp Leu Trp Arg Leu Val Glu Ser Gly Thr Asp Ala 
            20                  25                  30          


Ile Ser Gly Phe Pro Ala Asp Arg Gly Trp Asp Val Glu Asn Leu Tyr 
        35                  40                  45              


Asp Pro Asp Pro Glu Ala Ala Gly Lys Ser Tyr Cys Val Gln Gly Gly 
    50                  55                  60                  


Phe Leu Asp Ser Ala Gly Gly Phe Asp Ala Ser Phe Phe Gly Ile Ser 
65                  70                  75                  80  


Pro Arg Glu Ala Leu Ala Met Asp Pro Gln Gln Arg Leu Val Leu Glu 
                85                  90                  95      


Ala Ser Trp Glu Ala Phe Glu Arg Ala Gly Ile Glu Pro Gly Ser Leu 
            100                 105                 110         


Arg Gly Ser Asp Thr Gly Val Phe Met Gly Ala Tyr Pro Gly Gly Tyr 
        115                 120                 125             


Gly Val Gly Ala Asp Leu Gly Gly Phe Gly Ala Thr Ala Gly Ala Val 
    130                 135                 140                 


Ser Val Leu Ser Gly Arg Val Ser Tyr Phe Phe Gly Leu Glu Gly Pro 
145                 150                 155                 160 


Ala Val Thr Val Asp Thr Ala Cys Ser Ser Ser Leu Val Ala Leu His 
                165                 170                 175     


Gln Ala Gly Tyr Ala Leu Arg Gln Gly Glu Cys Ser Leu Ala Leu Val 
            180                 185                 190         


Gly Gly Val Thr Val Met Ala Thr Pro Gln Ser Phe Val Glu Phe Ser 
        195                 200                 205             


Arg Gln Arg Gly Leu Ala Ser Asp Gly Arg Cys Lys Ala Phe Ala Asp 
    210                 215                 220                 


Ala Ala Asp Gly Thr Gly Trp Ala Glu Gly Ala Gly Val Leu Leu Val 
225                 230                 235                 240 


Glu Arg Leu Ser Asp Ala Gln Ala Lys Gly His Gln Val Leu Ala Val 
                245                 250                 255     


Val Arg Gly Ser Ala Val Asn Gln Asp Gly Ala Ser Asn Gly Leu Ser 
            260                 265                 270         


Ala Pro Asn Gly Pro Ser Gln Gln Arg Val Ile Arg Ala Ala Leu Ser 
        275                 280                 285             


Asn Ala Gly Leu Ser Thr Ala Glu Val Asp Val Val Glu Ala His Gly 
    290                 295                 300                 


Thr Gly Thr Thr Leu Gly Asp Pro Ile Glu Ala Gln Ala Leu Leu Ala 
305                 310                 315                 320 


Thr Tyr Gly Gln Asp Arg Glu Gln Pro Leu Leu Leu Gly Ser Val Lys 
                325                 330                 335     


Ser Asn Leu Gly His Thr Gln Ala Ala Ala Gly Val Ser Gly Val Ile 
            340                 345                 350         


Lys Met Val Met Ala Leu Gln His Gly Leu Val Pro Arg Thr Leu His 
        355                 360                 365             


Val Asp Glu Pro Ser Arg His Val Asp Trp Thr Asp Gly Ala Val Ala 
    370                 375                 380                 


Leu Val Thr Glu Asn Gln Pro Trp Pro Asp Met Gly Arg Pro Arg Arg 
385                 390                 395                 400 


Ala Gly Val Ser Ser Phe Gly Ile Ser Gly Thr Asn Ala His Val Ile 
                405                 410                 415     


Leu Glu Ser Ala Pro Pro Thr Gln Ala Val Asp Asp Val Pro Pro Ala 
            420                 425                 430         


Glu Ala Pro Val Val Ala Ser Glu Leu Val Pro Leu Val Ile Ser Ala 
        435                 440                 445             


Arg Thr Leu Pro Ala Leu Val Glu Tyr Glu Asp Arg Leu Arg Ala Tyr 
    450                 455                 460                 


Leu Ala Ala Ser Pro Gly Val Asp Val Arg Gly Val Ala Ser Thr Leu 
465                 470                 475                 480 


Ala Val Thr Arg Ser Val Phe Glu His Arg Ala Val Leu Leu Gly Asp 
                485                 490                 495     


Asp Thr Val Thr Gly Thr Thr Val Ser Asp Pro Arg Val Val Phe Val 
            500                 505                 510         


Phe Pro Gly Gln Gly Ser Gln Arg Ala Gly Met Gly Glu Glu Leu Ala 
        515                 520                 525             


Ala Ala Phe Pro Val Phe Ala Arg Ile His Gln Gln Val Trp Gly Leu 
    530                 535                 540                 


Leu Asp Val Pro Asp Leu Glu Val Asn Glu Thr Gly Tyr Ala Gln Pro 
545                 550                 555                 560 


Ala Leu Phe Ala Leu Gln Val Ala Leu Phe Gly Leu Leu Glu Ser Trp 
                565                 570                 575     


Gly Val Arg Pro Asp Ala Val Val Gly His Ser Val Gly Glu Leu Ala 
            580                 585                 590         


Ala Gly Tyr Val Ser Gly Leu Trp Ser Leu Glu Asp Ala Cys Thr Leu 
        595                 600                 605             


Val Ser Ala Arg Ala Arg Leu Met Gln Ala Leu Pro Pro Gly Gly Val 
    610                 615                 620                 


Met Val Ala Val Pro Val Ser Glu Asp Glu Ala Arg Ala Val Leu Gly 
625                 630                 635                 640 


Glu Gly Val Glu Ile Ala Ala Val Asn Gly Pro Ser Ser Val Val Leu 
                645                 650                 655     


Ser Gly Asp Glu Thr Ala Val Leu Gln Ala Ala Ala Ala Leu Gly Lys 
            660                 665                 670         


Ser Thr Arg Leu Ala Thr Ser His Ala Phe His Ser Ala Arg Met Glu 
        675                 680                 685             


Pro Met Leu Glu Glu Phe Arg Thr Val Ala Glu Arg Leu Thr Tyr Gln 
    690                 695                 700                 


Thr Pro Arg Leu Ala Met Ala Ala Gly Asp Arg Val Thr Thr Ala Glu 
705                 710                 715                 720 


Tyr Trp Val Arg Gln Val Arg Asp Thr Val Arg Phe Gly Glu Gln Val 
                725                 730                 735     


Ala Ser Tyr Glu Asp Ala Val Phe Ile Glu Leu Gly Ala Asp Arg Ser 
            740                 745                 750         


Leu Ala Arg Leu Val Asp Gly Val Ala Met Leu His Thr Asp His Glu 
        755                 760                 765             


Ala Gln Ala Ala Ile Ser Ala Leu Ala His Leu Tyr Val Asn Gly Val 
    770                 775                 780                 


Thr Val Asp Trp Thr Ala Leu Leu Gly Asp Ala Pro Ala Thr Arg Val 
785                 790                 795                 800 


Asp Leu Pro Thr Tyr Ala Phe Gln His Gln Arg Tyr Trp Leu Glu Gly 
                805                 810                 815     


Trp Leu Ala Ala Leu Ala Pro Glu Glu Arg Ala Lys Ala Leu Leu Lys 
            820                 825                 830         


Val Val Arg Asp Thr Ala Ala Thr Val Leu Gly His Ala Asp Ala Arg 
        835                 840                 845             


Thr Ile Pro Val Thr Gly Ala Phe Arg Asp Leu Gly Ile Asp Ser Leu 
    850                 855                 860                 


Thr Ala Val Glu Leu Arg Asn Gly Leu Ala Lys Val Thr Gly Leu Arg 
865                 870                 875                 880 


Leu Pro Ala Thr Leu Val Phe Asp Tyr Pro Thr Pro Ala Val Leu Ala 
                885                 890                 895     


Ala Arg Leu 
            


<210>  150
<211>  924
<212>  PRT
<213>  Streptomyces rapamycinicus

<400>  150

Glu Pro Leu Ala Ile Val Gly Met Ala Cys Arg Leu Pro Gly Gly Val 
1               5                   10                  15      


Ser Ser Pro Glu Asp Leu Trp Arg Leu Val Glu Ser Gly Thr Asp Ala 
            20                  25                  30          


Ile Ser Gly Phe Pro Ala Asp Arg Gly Trp Asp Ala Glu Ser Leu Phe 
        35                  40                  45              


Asp Pro Asp Pro Ala Val Gly Lys Ser Tyr Cys Val Glu Gly Gly Phe 
    50                  55                  60                  


Leu Asp Ser Ala Ala Ser Phe Asp Ala Gly Phe Phe Gly Ile Ser Pro 
65                  70                  75                  80  


Arg Glu Ala Leu Ala Met Asp Pro Gln Gln Arg Leu Ile Met Glu Val 
                85                  90                  95      


Ser Trp Glu Ala Phe Glu Arg Ala Gly Ile Glu Pro Gly Ser Val Arg 
            100                 105                 110         


Gly Ser Asp Thr Gly Val Phe Met Gly Ala Tyr Ala Gly Gly Tyr Gly 
        115                 120                 125             


Ala Gly Ala Asp Leu Gly Gly Phe Ala Ala Thr Ala Ser Ala Thr Ser 
    130                 135                 140                 


Val Leu Ser Gly Arg Val Ser Tyr Phe Phe Gly Leu Glu Gly Pro Ala 
145                 150                 155                 160 


Ile Thr Val Asp Thr Ala Cys Ser Ser Ser Leu Val Ala Leu His Gln 
                165                 170                 175     


Ala Gly Tyr Ala Leu Arg Gln Gly Glu Cys Ser Leu Ala Leu Val Gly 
            180                 185                 190         


Gly Val Thr Val Met Ala Thr Pro Gln Ser Phe Val Glu Phe Ser Arg 
        195                 200                 205             


Gln Arg Gly Leu Ala Ser Asp Gly Arg Cys Lys Ala Phe Ala Asp Ser 
    210                 215                 220                 


Ala Asp Gly Thr Gly Trp Ala Glu Gly Val Gly Val Leu Leu Val Glu 
225                 230                 235                 240 


Arg Leu Ser Asp Ala Gln Ala Lys Gly His Gln Val Leu Ala Val Val 
                245                 250                 255     


Arg Ser Ser Ala Val Asn Gln Asp Gly Ala Ser Asn Gly Leu Ser Ala 
            260                 265                 270         


Pro Asn Gly Pro Ser Gln Gln Gly Val Ile Gln Ala Ala Leu Ser Asn 
        275                 280                 285             


Ala Gly Leu Ala Ala His Glu Val Asp Val Val Glu Ala His Gly Thr 
    290                 295                 300                 


Gly Thr Thr Leu Gly Asp Pro Ile Glu Ala Gln Ala Val Ile Ala Thr 
305                 310                 315                 320 


Tyr Gly Gln Asp Arg Glu Arg Pro Leu Leu Leu Gly Ser Leu Lys Ser 
                325                 330                 335     


Asn Ile Gly His Ala Gln Ala Ala Ser Gly Val Ser Gly Val Ile Lys 
            340                 345                 350         


Met Val Met Ala Leu Gln His Asn Thr Val Pro Arg Thr Leu His Val 
        355                 360                 365             


Asp Glu Pro Ser Arg His Val Asp Trp Ala Ala Gly Ala Val Glu Leu 
    370                 375                 380                 


Val Arg Glu Asn Gln Pro Trp Pro Gly Thr Asp Arg Pro Arg Arg Ala 
385                 390                 395                 400 


Gly Val Ser Ser Phe Gly Val Ser Gly Thr Asn Ala His Val Ile Leu 
                405                 410                 415     


Glu Ser Ala Pro Pro Ala Gln Pro Ala Glu Glu Ala Gln Pro Val Glu 
            420                 425                 430         


Thr Pro Val Val Ala Ser Asp Val Leu Pro Leu Val Ile Ser Ala Lys 
        435                 440                 445             


Thr Gln Pro Ala Leu Thr Glu His Glu Asp Arg Leu Arg Ala Tyr Leu 
    450                 455                 460                 


Ala Ala Ser Pro Gly Val Asp Thr Arg Ala Val Ala Ser Thr Leu Ala 
465                 470                 475                 480 


Val Thr Arg Ser Val Phe Glu His Arg Ala Val Leu Leu Gly Asp Asp 
                485                 490                 495     


Thr Val Thr Gly Thr Ala Val Ser Asp Pro Arg Val Val Phe Val Phe 
            500                 505                 510         


Pro Gly Gln Gly Trp Gln Trp Leu Gly Met Gly Ser Ala Leu Arg Asp 
        515                 520                 525             


Ser Ser Ile Val Phe Ala Glu Arg Met Ala Glu Cys Ala Ala Ala Leu 
    530                 535                 540                 


Arg Glu Phe Val Asp Trp Asp Leu Phe Thr Val Leu Asp Asp Pro Ala 
545                 550                 555                 560 


Val Val Asp Arg Val Asp Val Val Gln Pro Ala Ser Trp Ala Met Met 
                565                 570                 575     


Val Ser Leu Ala Ala Val Trp Gln Ala Ala Gly Val Arg Pro Asp Ala 
            580                 585                 590         


Val Ile Gly His Ser Gln Gly Glu Ile Ala Ala Ala Cys Val Ala Gly 
        595                 600                 605             


Ala Val Ser Met Arg Asp Ala Ala Arg Ile Val Thr Leu Arg Ser Gln 
    610                 615                 620                 


Ala Ile Ala Gly Leu Ala Gly Arg Gly Ala Met Ala Ser Val Ala Leu 
625                 630                 635                 640 


Pro Ala Gln Asp Val Glu Leu Val Asp Gly Ala Trp Ile Ala Ala His 
                645                 650                 655     


Asn Gly Pro Ala Ser Thr Val Ile Ala Gly Thr Pro Glu Ala Val Asp 
            660                 665                 670         


His Val Leu Thr Ala His Glu Ala Arg Gly Val Arg Val Arg Arg Ile 
        675                 680                 685             


Thr Val Asp Tyr Ala Ser His Thr Pro His Val Glu Leu Ile Arg Asp 
    690                 695                 700                 


Glu Leu Leu Asp Ile Thr Ser Asp Ser Ser Ser Gln Ala Pro Val Val 
705                 710                 715                 720 


Pro Trp Leu Ser Thr Val Asp Gly Ser Trp Val Asp Ser Pro Leu Asp 
                725                 730                 735     


Val Glu Tyr Trp Tyr Arg Asn Leu Arg Glu Pro Val Gly Phe His Pro 
            740                 745                 750         


Ala Val Gly Gln Leu Gln Ala Gln Gly Asp Thr Val Phe Val Glu Val 
        755                 760                 765             


Ser Ala Ser Pro Val Leu Leu Gln Ala Met Asp Asp Asp Val Val Thr 
    770                 775                 780                 


Val Ala Thr Leu Arg Arg Asp Asp Gly Asp Ala Thr Arg Met Leu Thr 
785                 790                 795                 800 


Ala Leu Ala Gln Ala Tyr Val His Gly Val Thr Val Asp Trp Pro Ala 
                805                 810                 815     


Ile Leu Gly Thr Thr Thr Thr Arg Val Asp Leu Pro Thr Tyr Ala Phe 
            820                 825                 830         


Gln His Gln Arg Tyr Trp Val Glu Trp Leu Ala Ala Leu Ala Pro Ala 
        835                 840                 845             


Glu Arg Glu Lys Ala Leu Leu Lys Val Val Cys Asp Ser Ala Ala Val 
    850                 855                 860                 


Val Leu Gly His Ala Asp Ala Arg Thr Ile Pro Val Thr Gly Ala Phe 
865                 870                 875                 880 


Lys Asp Leu Gly Val Asp Ser Leu Thr Ala Val Glu Leu Arg Asn Ser 
                885                 890                 895     


Leu Val Lys Ala Thr Gly Leu Arg Leu Pro Ala Thr Met Val Phe Asp 
            900                 905                 910         


Tyr Pro Thr Pro Thr Ala Leu Ala Ala Arg Leu Asp 
        915                 920                 


<210>  151
<211>  928
<212>  PRT
<213>  Streptomyces rapamycinicus

<400>  151

Glu Pro Leu Ala Ile Val Gly Met Ala Cys Arg Leu Pro Gly Gly Val 
1               5                   10                  15      


Ser Ser Pro Glu Asp Leu Trp Arg Leu Val Glu Ser Gly Thr Asp Ala 
            20                  25                  30          


Val Ser Gly Phe Pro Thr Asp Arg Gly Trp Asp Val Glu Gly Leu Phe 
        35                  40                  45              


Asp Pro Asp Pro Asp Ala Ala Gly Lys Ser Tyr Arg Ala Glu Gly Gly 
    50                  55                  60                  


Phe Leu Asp Thr Ala Ala Gly Phe Asp Ala Gly Phe Phe Gly Ile Ser 
65                  70                  75                  80  


Pro Arg Glu Ala Leu Ala Met Asp Pro Gln Gln Arg Leu Leu Leu Glu 
                85                  90                  95      


Val Ser Trp Glu Ala Phe Glu Arg Ala Gly Ile Glu Pro Gly Ser Val 
            100                 105                 110         


Arg Gly Ser Asp Thr Gly Val Phe Ile Gly Ala Phe Pro Val Gly Tyr 
        115                 120                 125             


Gly Ala Gly Ala Ala Arg Glu Gly Tyr Gly Ala Thr Ala Ala Pro Asn 
    130                 135                 140                 


Val Leu Ser Gly Arg Leu Ser Tyr Phe Phe Gly Leu Glu Gly Pro Ala 
145                 150                 155                 160 


Ile Thr Met Asp Thr Ala Cys Ser Ser Ser Leu Val Ala Leu His Leu 
                165                 170                 175     


Ala Ala Gln Ala Leu Arg Asn Gly Glu Cys Ser Met Ala Leu Ala Gly 
            180                 185                 190         


Gly Val Thr Val Met Ala Thr Pro Glu Val Phe Thr Glu Phe Ala Arg 
        195                 200                 205             


Gln Arg Gly Leu Ala Ser Asp Gly Arg Cys Lys Ala Phe Ala Asp Ser 
    210                 215                 220                 


Ala Asp Gly Ala Gly Phe Ser Glu Gly Ala Gly Leu Leu Leu Val Glu 
225                 230                 235                 240 


Arg Leu Ser Asp Ala Arg Arg Asn Gly His Gln Val Leu Ala Val Val 
                245                 250                 255     


Arg Gly Ser Ala Val Asn Gln Asp Gly Ala Ser Asn Gly Phe Thr Ala 
            260                 265                 270         


Pro Asn Gly Pro Ala Gln Gln Arg Val Ile Arg Gln Ala Leu Ala Asn 
        275                 280                 285             


Ala Gly Leu Thr Thr Ala Glu Val Asp Val Val Glu Ala His Gly Thr 
    290                 295                 300                 


Gly Thr Thr Leu Gly Asp Pro Ile Glu Ala Gln Ala Val Ile Ala Thr 
305                 310                 315                 320 


Tyr Gly Gln Asp Arg Glu Gln Pro Leu Leu Leu Gly Thr Leu Lys Ser 
                325                 330                 335     


Asn Val Gly His Thr Gln Ala Ala Ala Gly Val Ser Gly Val Ile Lys 
            340                 345                 350         


Met Val Met Ala Leu Gln His Ser Thr Val Pro Arg Thr Leu His Val 
        355                 360                 365             


Asn Glu Pro Ser Arg His Val Asp Trp Ser Ala Gly Ala Val Glu Leu 
    370                 375                 380                 


Val Thr Glu Asn Gln Ser Trp Pro Val Thr Gly Arg Pro Arg Arg Ala 
385                 390                 395                 400 


Gly Val Ser Ala Phe Gly Val Ser Gly Thr Asn Ala His Val Val Leu 
                405                 410                 415     


Glu Ser Ala Pro Pro Ala Gln Ser Val Asn Asn Ala Gln Pro Val Ala 
            420                 425                 430         


Thr Pro Val Val Ala Ser Glu Leu Val Pro Leu Val Ile Ser Ala Lys 
        435                 440                 445             


Thr Leu Pro Ala Leu Thr Glu His Glu Asp Arg Leu Arg Ala Tyr Leu 
    450                 455                 460                 


Ala Ala Ser Pro Gly Ala Asp Met Arg Ala Val Gly Ser Thr Leu Ala 
465                 470                 475                 480 


Leu Thr Arg Ser Val Phe Glu His Arg Ala Val Leu Leu Gly His Asp 
                485                 490                 495     


Thr Val Thr Val Thr Gly Thr Gly Thr Ala Val Ser Asn Pro Arg Val 
            500                 505                 510         


Val Phe Val Phe Pro Gly Gln Gly Trp Gln Trp Leu Gly Met Gly Ser 
        515                 520                 525             


Ala Leu Arg Gly Ser Ser Val Val Phe Ala Glu Arg Met Ala Glu Cys 
    530                 535                 540                 


Ala Ala Ala Leu Ser Glu Phe Val Asp Trp Asp Leu Phe Ala Val Leu 
545                 550                 555                 560 


Asp Asp Pro Ala Val Val Asp Arg Val Asp Val Val Gln Pro Ala Ser 
                565                 570                 575     


Trp Ala Val Met Val Ser Leu Ala Ala Val Trp Gln Ala Ala Gly Val 
            580                 585                 590         


Arg Pro Asp Ala Val Ile Gly His Ser Gln Gly Glu Ile Ala Ala Ala 
        595                 600                 605             


Cys Val Ala Gly Ala Val Ser Leu Arg Asp Ala Ala Arg Ile Val Thr 
    610                 615                 620                 


Leu Arg Ser Gln Ala Ile Ala Gly Leu Ala Gly Arg Gly Ala Met Ala 
625                 630                 635                 640 


Ser Val Ala Leu Pro Ala His Glu Ile Glu Leu Val Asp Gly Ala Trp 
                645                 650                 655     


Ile Ala Ala His Asn Gly Pro Ala Ser Thr Val Val Ala Gly Ala Pro 
            660                 665                 670         


Glu Ala Val Asp Arg Val Leu Ala Val His Glu Ala Arg Gly Val Arg 
        675                 680                 685             


Val Arg Arg Ile Ala Val Asp Tyr Ala Ser His Thr Pro His Val Glu 
    690                 695                 700                 


Leu Ile Arg Asp Glu Leu Leu Asp Ile Thr Ala Gly Ile Gly Ser Gln 
705                 710                 715                 720 


Ala Pro Val Val Pro Trp Leu Ser Thr Val Asp Gly Thr Trp Val Glu 
                725                 730                 735     


Gly Pro Leu Asp Val Glu Tyr Trp Tyr Arg Asn Leu Arg Glu Pro Val 
            740                 745                 750         


Gly Phe Asp Ser Ala Val Gly Gln Leu Arg Ala Glu Gly Asp Thr Val 
        755                 760                 765             


Phe Val Glu Val Ser Ala Ser Pro Val Leu Leu Gln Ala Met Asp Asp 
    770                 775                 780                 


Asp Val Val Thr Val Ala Thr Leu Arg Arg Asp Asp Gly Asp Ala Thr 
785                 790                 795                 800 


Arg Met Leu Thr Ala Leu Ala Gln Ala Phe Val Glu Gly Val Thr Val 
                805                 810                 815     


Asp Trp Pro Ala Ile Leu Gly Thr Ala Thr Thr Arg Val Asp Leu Pro 
            820                 825                 830         


Thr Tyr Ala Phe Gln His Gln Arg Phe Trp Ala Glu Gly Trp Leu Ala 
        835                 840                 845             


Arg Leu Ala Pro Val Glu Arg Glu Lys Ala Leu Leu Lys Leu Val Cys 
    850                 855                 860                 


Asp Gly Ala Ala Thr Val Leu Gly His Ala Asp Ala Ser Thr Ile Pro 
865                 870                 875                 880 


Ala Thr Ala Ala Phe Lys Asp Leu Gly Ile Asp Ser Leu Thr Ala Val 
                885                 890                 895     


Glu Leu Arg Asn Ser Leu Thr Lys Ala Thr Gly Leu Arg Leu Pro Ala 
            900                 905                 910         


Thr Leu Val Phe Asp Tyr Pro Thr Pro Thr Ala Leu Ala Ala Arg Leu 
        915                 920                 925             


<210>  152
<211>  893
<212>  PRT
<213>  Streptomyces rapamycinicus

<400>  152

Glu Pro Leu Ala Ile Val Gly Met Ala Cys Arg Leu Pro Gly Gly Val 
1               5                   10                  15      


Ser Ser Pro Glu Asp Leu Trp Arg Leu Leu Glu Ser Gly Thr Asp Ala 
            20                  25                  30          


Val Ser Gly Phe Pro Thr Asp Arg Gly Trp Asp Val Glu Asn Leu Phe 
        35                  40                  45              


Gly Pro Ala Ala Gly Asp Ser Tyr Arg Leu Gln Gly Gly Phe Leu Asp 
    50                  55                  60                  


Ala Ala Ala Gly Phe Asp Ala Ser Phe Phe Gly Ile Ser Pro Arg Glu 
65                  70                  75                  80  


Ala Leu Ala Met Asp Pro Gln Gln Arg Leu Val Leu Glu Val Ser Trp 
                85                  90                  95      


Glu Ala Phe Glu Arg Ala Gly Ile Glu Pro Gly Ser Val Arg Gly Thr 
            100                 105                 110         


Asp Thr Gly Val Phe Met Gly Ala Tyr Pro Gly Gly Tyr Gly Ile Gly 
        115                 120                 125             


Ala Asp Leu Gly Gly Phe Gly Ala Thr Ala Ser Ala Val Ser Val Leu 
    130                 135                 140                 


Ser Gly Arg Val Ser Tyr Phe Phe Gly Leu Glu Gly Pro Ala Ile Thr 
145                 150                 155                 160 


Val Asp Thr Ala Cys Ser Ser Ser Leu Val Ala Leu His Gln Ala Gly 
                165                 170                 175     


Tyr Ala Leu Arg Gln Gly Glu Cys Ser Leu Ala Leu Val Gly Gly Val 
            180                 185                 190         


Thr Val Met Ala Thr Pro Gln Thr Phe Val Glu Phe Ala Arg Gln Gly 
        195                 200                 205             


Gly Leu Ala Gly Asp Gly Arg Ser Lys Ala Phe Ala Asp Ser Ala Asp 
    210                 215                 220                 


Gly Ala Gly Phe Ser Glu Gly Val Gly Val Leu Leu Val Glu Arg Leu 
225                 230                 235                 240 


Ser Asp Ala Gln Ala Lys Gly His Gln Val Leu Ala Met Leu Arg Ser 
                245                 250                 255     


Ser Ala Val Asn Gln Asp Gly Ala Ser Asn Gly Leu Thr Ala Pro Asn 
            260                 265                 270         


Gly Pro Ser Gln Gln Arg Val Ile Gln Ala Ala Leu Ser Asn Ala Gly 
        275                 280                 285             


Leu Ala Ala His Glu Val Asp Val Val Glu Ala His Gly Thr Gly Thr 
    290                 295                 300                 


Thr Leu Gly Asp Pro Ile Glu Ala Gln Ala Leu Leu Ala Thr Tyr Gly 
305                 310                 315                 320 


Gln Asp Arg Glu Gln Pro Leu Leu Leu Gly Ser Val Lys Ser Asn Leu 
                325                 330                 335     


Gly His Thr Gln Ala Ala Ala Gly Val Ser Gly Val Ile Lys Met Val 
            340                 345                 350         


Met Ala Leu Gln Arg Gly Phe Val Pro Arg Thr Leu His Val Asp Glu 
        355                 360                 365             


Pro Ser Arg His Val Asp Trp Ser Ala Gly Ala Val Ala Leu Val Thr 
    370                 375                 380                 


Glu Asn Gln Pro Trp Pro Asp Met Gly Arg Ala Arg Arg Ala Gly Val 
385                 390                 395                 400 


Ser Ser Phe Gly Ile Ser Gly Thr Asn Ala His Val Ile Leu Glu Ser 
                405                 410                 415     


Ala Pro Pro Thr Gln Pro Ala Asp Asn Ala Val Ile Glu Arg Ala Pro 
            420                 425                 430         


Glu Trp Leu Pro Met Val Ile Ser Ala Arg Thr Gln Ser Ala Leu Thr 
        435                 440                 445             


Glu His Glu Gly Arg Leu Arg Ala Tyr Leu Ala Ala Ser Pro Gly Val 
    450                 455                 460                 


Asp Met Arg Ala Val Ala Ser Thr Leu Ala Met Thr Arg Ser Val Phe 
465                 470                 475                 480 


Glu His Arg Ala Val Leu Leu Gly Asp Asp Thr Val Thr Gly Thr Ala 
                485                 490                 495     


Ala Thr Asp Pro Arg Val Val Phe Val Phe Pro Gly Gln Gly Ser Gln 
            500                 505                 510         


Arg Ala Gly Met Gly Glu Glu Leu Ala Ala Ala Phe Pro Val Phe Ala 
        515                 520                 525             


Arg Ile His Gln Gln Val Trp Asp Leu Leu Asp Val Pro Asp Leu Glu 
    530                 535                 540                 


Val Asn Glu Thr Gly Tyr Ala Gln Pro Ala Leu Phe Ala Leu Gln Val 
545                 550                 555                 560 


Ala Leu Phe Gly Leu Leu Glu Ser Trp Gly Val Arg Pro Asp Ala Val 
                565                 570                 575     


Val Gly His Ser Val Gly Glu Leu Ala Ala Gly Tyr Val Ser Gly Leu 
            580                 585                 590         


Trp Ser Leu Glu Asp Ala Cys Thr Leu Val Ser Ala Arg Ala Arg Leu 
        595                 600                 605             


Met Gln Ala Leu Pro Ala Gly Gly Val Met Val Ala Val Pro Val Ser 
    610                 615                 620                 


Glu Asp Glu Ala Arg Ala Val Leu Gly Glu Gly Val Glu Ile Ala Ala 
625                 630                 635                 640 


Val Asn Gly Pro Ser Ser Val Val Leu Ser Gly Asp Glu Ala Ala Val 
                645                 650                 655     


Leu Gln Ala Ala Glu Gly Leu Gly Lys Trp Thr Arg Leu Ala Thr Ser 
            660                 665                 670         


His Ala Phe His Ser Ala Arg Met Glu Pro Met Leu Glu Glu Phe Arg 
        675                 680                 685             


Thr Val Ala Glu Gly Leu Thr Tyr Arg Thr Pro Gln Val Ser Met Ala 
    690                 695                 700                 


Ala Gly Asp Gln Val Thr Thr Thr Glu Tyr Trp Val Arg Gln Val Arg 
705                 710                 715                 720 


Asp Thr Val Arg Phe Gly Glu Gln Val Ala Ser Tyr Glu Asp Ala Val 
                725                 730                 735     


Phe Val Glu Leu Gly Ala Asp Arg Ser Leu Ala Arg Leu Val Asp Gly 
            740                 745                 750         


Val Ala Met Leu His Gly Asp His Glu Ala Gln Ala Ala Val Ser Ala 
        755                 760                 765             


Leu Ala His Leu Tyr Val Asn Gly Val Thr Val Asp Trp Pro Ala Leu 
    770                 775                 780                 


Leu Gly Asp Ala Pro Ala Thr Arg Val Asp Leu Pro Thr Tyr Ala Phe 
785                 790                 795                 800 


Gln His Gln Arg Tyr Trp Leu Glu Gly Arg Trp Leu Ala Ala Leu Ala 
                805                 810                 815     


Pro Glu Glu Arg Ala Lys Ala Leu Val Lys Val Val Cys Asp Ser Ala 
            820                 825                 830         


Ala Thr Val Leu Gly His Ala Asp Val Asp Ser Ile Pro Val Thr Ala 
        835                 840                 845             


Ala Phe Arg Asp Leu Gly Val Asp Ser Leu Thr Ala Val Glu Leu Arg 
    850                 855                 860                 


Asn Ser Leu Thr Lys Ala Thr Gly Leu Arg Leu Pro Ala Thr Leu Val 
865                 870                 875                 880 


Phe Asp Tyr Pro Thr Pro Gly Ala Leu Ala Ala Arg Leu 
                885                 890             


<210>  153
<211>  901
<212>  PRT
<213>  Streptomyces rapamycinicus

<400>  153

Glu Pro Leu Ala Ile Val Gly Met Ala Cys Arg Leu Pro Gly Gly Val 
1               5                   10                  15      


Ser Ser Pro Glu Asp Leu Trp Arg Leu Val Glu Ser Gly Thr Asp Ala 
            20                  25                  30          


Ile Ser Gly Phe Pro Thr Asp Arg Gly Trp Asp Val Glu Asn Leu Ser 
        35                  40                  45              


Asp Pro Asp Ala Ala Gly Lys Ser Tyr Cys Val Glu Gly Gly Phe Leu 
    50                  55                  60                  


Ala Thr Ala Ala Asn Phe Asp Ala Ser Phe Phe Gly Ile Ser Pro Arg 
65                  70                  75                  80  


Glu Ala Leu Ala Met Asp Pro Gln Gln Arg Leu Val Leu Glu Val Ser 
                85                  90                  95      


Trp Glu Ala Phe Glu Arg Ala Gly Ile Glu Pro Gly Ser Val Arg Gly 
            100                 105                 110         


Ser Asp Thr Gly Val Phe Met Gly Ala Phe Pro Gly Gly Tyr Gly Ile 
        115                 120                 125             


Gly Ala Asp Leu Glu Gly Tyr Gly Ala Thr Ala Gly Leu Asn Val Leu 
    130                 135                 140                 


Ser Gly Arg Leu Ser Tyr Phe Phe Gly Leu Glu Gly Pro Ala Val Thr 
145                 150                 155                 160 


Val Asp Thr Ala Cys Ser Ser Ser Leu Val Ala Leu His Gln Ala Gly 
                165                 170                 175     


Tyr Ala Leu Arg Gln Gly Glu Cys Ser Leu Ala Leu Ile Gly Gly Val 
            180                 185                 190         


Thr Val Met Ala Thr Pro His Thr Phe Val Glu Phe Ser Arg Gln Arg 
        195                 200                 205             


Gly Leu Ala Ser Asp Gly Arg Cys Lys Ala Phe Ala Asp Ser Ala Asp 
    210                 215                 220                 


Gly Thr Gly Trp Ser Glu Gly Val Gly Val Leu Leu Val Glu Arg Leu 
225                 230                 235                 240 


Ser Asp Ala Gln Ala Lys Gly His Gln Val Leu Ala Val Val Arg Ser 
                245                 250                 255     


Ser Ala Val Asn Gln Asp Gly Ala Ser Asn Gly Leu Ser Ala Pro Asn 
            260                 265                 270         


Gly Pro Ser Gln Gln Arg Val Ile Arg Gln Ala Leu Ala Asn Ala Gly 
        275                 280                 285             


Leu Thr Thr Ala Glu Val Asp Val Val Glu Ala His Gly Thr Gly Thr 
    290                 295                 300                 


Thr Leu Gly Asp Pro Ile Glu Ala Gln Ala Val Ile Ala Thr Tyr Gly 
305                 310                 315                 320 


Gln Asp Arg Asp Gln Pro Val Leu Leu Gly Ser Val Lys Ser Asn Val 
                325                 330                 335     


Gly His Thr Gln Ala Ala Ala Gly Val Ser Gly Val Ile Lys Met Val 
            340                 345                 350         


Met Ala Leu Gln His Gly Leu Val Pro Arg Thr Leu His Val Asp Glu 
        355                 360                 365             


Pro Ser Arg His Val Asp Trp Thr Asp Gly Ala Val Glu Leu Val Thr 
    370                 375                 380                 


Glu Asn Gln Ser Trp Pro Glu Ala Gly Arg Pro Arg Arg Ala Gly Val 
385                 390                 395                 400 


Ser Ser Phe Gly Val Ser Gly Thr Asn Ala His Val Ile Leu Glu Ser 
                405                 410                 415     


Ala Pro Pro Thr Gln Ala Val Asp Asp Val Arg Pro Ala Asp Ala Pro 
            420                 425                 430         


Val Val Ala Ser Val Met Ala Ser Glu Leu Val Pro Leu Val Ile Ser 
        435                 440                 445             


Ala Lys Thr Gln Ser Ala Leu Ala Glu Tyr Glu Gly Arg Leu Arg Ala 
    450                 455                 460                 


Tyr Leu Ala Ala Ser Pro Gly Val Asp Met Arg Ala Val Ala Ser Thr 
465                 470                 475                 480 


Leu Ala Met Thr Arg Ser Val Phe Glu His Arg Ala Val Ile Val Gly 
                485                 490                 495     


Asp Asp Thr Val Ser Gly Thr Ala Ala Thr Asp Pro Arg Val Val Phe 
            500                 505                 510         


Val Phe Pro Gly Gln Gly Ser Gln Arg Ala Gly Met Gly Ala Glu Leu 
        515                 520                 525             


Ala Ala Ala Phe Pro Val Phe Ala Arg Ile His Gln Gln Val Trp Asp 
    530                 535                 540                 


Leu Leu Asp Val Pro Asp Leu Glu Val Asn Glu Thr Gly Tyr Ala Gln 
545                 550                 555                 560 


Pro Ala Leu Phe Ala Leu Gln Val Ala Leu Phe Gly Leu Leu Glu Ser 
                565                 570                 575     


Trp Gly Val Arg Pro Asp Ala Val Ile Gly His Ser Val Gly Glu Leu 
            580                 585                 590         


Ala Ala Ala Tyr Val Ser Gly Leu Trp Ser Leu Glu Asp Ala Cys Thr 
        595                 600                 605             


Leu Val Ser Ala Arg Ala Arg Leu Met Gln Ala Leu Pro Ala Gly Gly 
    610                 615                 620                 


Val Met Val Ala Val Pro Val Ser Glu Asp Glu Ala Arg Ala Val Leu 
625                 630                 635                 640 


Gly Glu Gly Val Glu Ile Ala Ala Val Asn Gly Pro Ser Ser Val Val 
                645                 650                 655     


Leu Ser Gly Asp Glu Ala Ala Val Leu Gln Ala Ala Glu Gly Leu Gly 
            660                 665                 670         


Lys Trp Thr Arg Leu Ala Thr Ser His Ala Phe His Ser Ala Arg Met 
        675                 680                 685             


Glu Pro Met Leu Glu Glu Phe Arg Ala Val Ala Gln Gly Leu Thr Tyr 
    690                 695                 700                 


His Ala Pro Gly Val Val Met Ala Ala Gly Asp Arg Val Met Thr Ala 
705                 710                 715                 720 


Glu Tyr Trp Val Arg Gln Val Arg Asp Thr Val Arg Phe Gly Glu Gln 
                725                 730                 735     


Val Ala Ser Tyr Glu Asp Ala Val Phe Val Glu Leu Gly Ala Asp Arg 
            740                 745                 750         


Ser Leu Ala Arg Leu Val Asp Gly Val Ala Met Leu His Gly Asp His 
        755                 760                 765             


Glu Thr Gln Ala Ala Ile Gly Ala Leu Ala His Leu Tyr Val Asn Gly 
    770                 775                 780                 


Val Thr Val Asp Trp Thr Ala Leu Leu Gly Asp Val Pro Val Thr Arg 
785                 790                 795                 800 


Val Asp Leu Pro Thr Tyr Ala Phe Gln Gln Gln Arg Tyr Trp Ala Glu 
                805                 810                 815     


Arg Trp Leu Ala Ala Leu Ala Pro Ala Glu Arg Glu Lys Ala Leu Leu 
            820                 825                 830         


Lys Leu Val Ser Asp Gly Ala Ala Thr Val Leu Gly His Ala Asp Thr 
        835                 840                 845             


Ser Thr Ile Pro Ala Thr Thr Ala Phe Lys Asp Leu Gly Ile Asp Ser 
    850                 855                 860                 


Leu Thr Ala Val Glu Leu Arg Asn Ser Leu Ala Lys Ala Thr Glu Leu 
865                 870                 875                 880 


Arg Leu Pro Ala Thr Leu Val Phe Asp Tyr Pro Thr Pro Thr Ala Leu 
                885                 890                 895     


Ala Ala Arg Leu Asp 
            900     


<210>  154
<211>  924
<212>  PRT
<213>  Streptomyces rapamycinicus

<400>  154

Glu Pro Leu Ala Ile Val Gly Met Ala Cys Arg Leu Pro Gly Gly Val 
1               5                   10                  15      


Ser Ser Pro Glu Asp Leu Trp Arg Leu Val Glu Ser Gly Thr Asp Ala 
            20                  25                  30          


Ile Ser Gly Phe Pro Thr Asp Arg Gly Trp Asp Val Glu Asn Leu Tyr 
        35                  40                  45              


Asp Pro Asp Pro Asp Ala Pro Gly Lys Ser Tyr Ser Val Gln Gly Gly 
    50                  55                  60                  


Phe Leu Asp Ala Ala Ala Gly Phe Asp Ala Ser Phe Phe Gly Ile Ser 
65                  70                  75                  80  


Pro Arg Glu Ala Leu Ala Met Asp Pro Gln Gln Arg Leu Met Leu Glu 
                85                  90                  95      


Val Ser Trp Glu Ala Phe Glu Arg Ala Gly Ile Glu Pro Gly Ser Val 
            100                 105                 110         


Arg Gly Ser Asp Thr Gly Val Phe Ile Gly Ala Tyr Pro Gly Gly Tyr 
        115                 120                 125             


Gly Ile Gly Ala Asp Leu Gly Gly Phe Gly Thr Thr Ala Gly Ala Ala 
    130                 135                 140                 


Ser Val Leu Ser Gly Arg Val Ser Tyr Phe Phe Gly Leu Glu Gly Pro 
145                 150                 155                 160 


Ala Phe Thr Val Asp Thr Ala Cys Ser Ser Ser Leu Val Ala Leu His 
                165                 170                 175     


Gln Ala Gly Tyr Ala Leu Arg Gln Gly Glu Cys Ser Leu Ala Leu Val 
            180                 185                 190         


Gly Gly Val Thr Val Met Ala Thr Pro Gln Thr Phe Val Glu Phe Ser 
        195                 200                 205             


Arg Gln Arg Gly Leu Ser Ala Asp Gly Arg Cys Lys Ala Phe Ala Asp 
    210                 215                 220                 


Ala Ala Asp Gly Thr Gly Trp Ala Glu Gly Val Gly Val Leu Leu Val 
225                 230                 235                 240 


Glu Arg Leu Ser Asp Ala Gln Ala Asn Gly His Gln Ile Leu Ala Val 
                245                 250                 255     


Val Arg Ser Ser Ala Val Asn Gln Asp Gly Ala Ser Asn Gly Leu Ser 
            260                 265                 270         


Ala Pro Asn Gly Pro Ser Gln Gln Arg Val Ile Arg Ala Ala Leu Ser 
        275                 280                 285             


Asn Ala Gly Leu Ala Pro His Glu Val Asp Val Val Glu Ala His Gly 
    290                 295                 300                 


Thr Gly Thr Thr Leu Gly Asp Pro Ile Glu Ala Gln Ala Val Ile Ala 
305                 310                 315                 320 


Thr Tyr Gly Gln Gly Arg Gly Glu Pro Leu Leu Leu Gly Ser Leu Lys 
                325                 330                 335     


Ser Asn Val Gly His Thr Gln Ala Ala Ala Gly Val Ser Gly Val Ile 
            340                 345                 350         


Lys Met Val Met Ala Leu Gln His Ser Met Val Pro Arg Thr Leu His 
        355                 360                 365             


Val Asp Glu Pro Ser Arg His Val Asp Trp Ser Ala Gly Ala Val Glu 
    370                 375                 380                 


Leu Val Ala Glu Asn Gln Pro Trp Pro Glu Thr Gly Arg Pro Arg Arg 
385                 390                 395                 400 


Ala Gly Val Ser Ser Phe Gly Ile Ser Gly Thr Asn Ala His Val Ile 
                405                 410                 415     


Leu Glu Ser Ala Pro Ala Gln Ser Val Gly Asp Thr Ala Gly Ser Thr 
            420                 425                 430         


Pro Val Leu Val Ser Glu Leu Val Pro Leu Val Ile Ser Ala Lys Thr 
        435                 440                 445             


Gln Pro Ala Leu Thr Glu His Glu Asp Arg Leu Arg Ala Tyr Leu Ala 
    450                 455                 460                 


Ala Ser Pro Gly Val Asp Ile Arg Ala Val Ala Ser Thr Leu Ala Val 
465                 470                 475                 480 


Thr Arg Ser Val Phe Glu His Arg Ala Val Leu Leu Gly Asp Glu Thr 
                485                 490                 495     


Val Thr Gly Thr Ala Val Ser Asp Pro Arg Ile Val Phe Val Phe Pro 
            500                 505                 510         


Gly Gln Gly Trp Gln Trp Leu Gly Met Gly Ser Ala Leu Arg Asp Ser 
        515                 520                 525             


Ser Val Val Phe Ala Glu Arg Met Ala Glu Cys Ala Ala Ala Leu Ser 
    530                 535                 540                 


Glu Phe Val Asp Trp Asp Leu Phe Ala Val Leu Asp Asp Pro Ala Val 
545                 550                 555                 560 


Val Asp Arg Val Asp Val Val Gln Pro Ala Ser Trp Ala Val Met Val 
                565                 570                 575     


Ser Leu Ala Ala Val Trp Gln Ala Ala Gly Val Arg Pro Asp Ala Val 
            580                 585                 590         


Ile Gly His Ser Gln Gly Glu Ile Ala Ala Ala Cys Val Ala Gly Ala 
        595                 600                 605             


Val Ser Met Arg Asp Ala Ala Arg Ile Val Thr Leu Arg Ser Gln Ala 
    610                 615                 620                 


Ile Ala Gly Leu Ala Gly Arg Gly Ala Met Ala Ser Val Ala Leu Pro 
625                 630                 635                 640 


Ala Gln Asp Val Glu Leu Val Asp Gly Ala Trp Ile Ala Ala His Asn 
                645                 650                 655     


Gly Pro Ala Ser Thr Val Ile Ala Gly Thr Pro Glu Ala Val Asp His 
            660                 665                 670         


Val Leu Thr Ala His Glu Ala Gln Gly Val Arg Val Arg Arg Ile Thr 
        675                 680                 685             


Val Asp Tyr Ala Ser His Thr Pro His Val Glu Leu Ile Arg Asp Glu 
    690                 695                 700                 


Leu Leu Asp Ile Thr Ser Asp Ser Ser Ser Gln Thr Pro Leu Val Pro 
705                 710                 715                 720 


Trp Leu Ser Thr Val Asp Gly Thr Trp Val Asp Ser Pro Leu Asp Gly 
                725                 730                 735     


Glu Tyr Trp Tyr Arg Asn Leu Arg Glu Pro Val Gly Phe His Pro Ala 
            740                 745                 750         


Val Ser Gln Leu Gln Ala Gln Gly Asp Thr Val Phe Val Glu Val Ser 
        755                 760                 765             


Ala Ser Pro Val Leu Leu Gln Ala Met Asp Asp Asp Val Val Thr Val 
    770                 775                 780                 


Ala Thr Leu Arg Arg Asp Asp Gly Asp Ala Thr Arg Met Leu Thr Ala 
785                 790                 795                 800 


Leu Ala Gln Ala Tyr Val His Gly Val Thr Val Asp Trp Arg Ala Val 
                805                 810                 815     


Leu Gly Asp Val Pro Ala Thr Arg Val Asp Leu Pro Thr Tyr Ala Phe 
            820                 825                 830         


Gln His Gln Arg Tyr Trp Ala Glu Ala Trp Leu Val Gly Leu Ala Pro 
        835                 840                 845             


Glu Glu Arg Ala Lys Ala Leu Leu Lys Val Val Arg Asp Ser Ala Ala 
    850                 855                 860                 


Thr Val Leu Gly His Ala Asp Ala Arg Ser Ile Pro Ala Thr Gly Ala 
865                 870                 875                 880 


Phe Lys Asp Leu Gly Val Asp Ser Leu Thr Ala Val Glu Leu Arg Asn 
                885                 890                 895     


Ser Leu Thr Lys Ala Thr Gly Leu Arg Leu Pro Ala Thr Met Val Phe 
            900                 905                 910         


Asp Tyr Pro Thr Pro Ala Asp Leu Ala Ala Arg Leu 
        915                 920                 


<210>  155
<211>  922
<212>  PRT
<213>  Streptomyces rapamycinicus

<400>  155

Glu Pro Leu Ala Ile Val Gly Met Ala Cys Arg Leu Pro Gly Gly Val 
1               5                   10                  15      


Ser Ser Pro Glu Asp Leu Trp Arg Leu Leu Glu Ser Gly Thr Asp Ala 
            20                  25                  30          


Val Ser Gly Phe Pro Thr Asp Arg Gly Trp Asp Val Glu Asn Leu Tyr 
        35                  40                  45              


Asp Met Ala Gly Lys Ser His Arg Ala Glu Gly Gly Phe Leu Asp Ala 
    50                  55                  60                  


Ala Ala Gly Phe Asp Ala Gly Phe Phe Gly Ile Ser Pro Arg Glu Ala 
65                  70                  75                  80  


Leu Ala Met Asp Pro Gln Gln Arg Leu Val Leu Glu Val Ser Trp Glu 
                85                  90                  95      


Ala Phe Glu Arg Ala Gly Ile Glu Pro Gly Ser Val Arg Gly Ser Asp 
            100                 105                 110         


Thr Gly Val Phe Met Gly Ala Tyr Pro Gly Gly Tyr Gly Ala Gly Ala 
        115                 120                 125             


Asp Leu Gly Gly Phe Ala Ala Thr Ala Ser Ala Thr Ser Val Leu Ser 
    130                 135                 140                 


Gly Arg Val Ser Tyr Phe Phe Gly Leu Glu Gly Pro Ala Phe Thr Val 
145                 150                 155                 160 


Asp Thr Ala Cys Ser Ser Ser Leu Val Ala Leu His Gln Ala Gly Tyr 
                165                 170                 175     


Ala Leu Arg Gln Gly Glu Cys Ser Leu Ala Leu Val Gly Gly Val Thr 
            180                 185                 190         


Val Met Ala Thr Pro Glu Leu Phe Thr Glu Phe Ser Arg Gln Arg Gly 
        195                 200                 205             


Leu Ala Ser Asp Gly Arg Cys Lys Ala Phe Ala Asp Ser Ala Asp Gly 
    210                 215                 220                 


Thr Gly Trp Ala Glu Gly Val Gly Val Leu Leu Val Glu Arg Leu Ser 
225                 230                 235                 240 


Asp Ala Gln Ala Lys Gly His Gln Val Leu Ala Val Val Arg Ser Ser 
                245                 250                 255     


Ala Val Asn Gln Asp Gly Ala Ser Asn Gly Leu Thr Ala Pro Asn Gly 
            260                 265                 270         


Pro Ser Gln Gln Arg Val Ile Gln Ala Ala Leu Ser Asn Ala Gly Leu 
        275                 280                 285             


Ala Ala His Glu Val Asp Val Val Glu Ala His Gly Thr Gly Thr Thr 
    290                 295                 300                 


Leu Gly Asp Pro Ile Glu Ala Gln Ala Val Ile Ala Thr Tyr Gly Gln 
305                 310                 315                 320 


Asp Arg Glu Arg Pro Leu Leu Leu Gly Ser Leu Lys Ser Asn Ile Gly 
                325                 330                 335     


His Ala Gln Ala Ala Ser Gly Val Ser Gly Val Ile Lys Met Val Met 
            340                 345                 350         


Ala Leu Gln His Asn Thr Val Pro Arg Thr Leu His Val Asp Glu Pro 
        355                 360                 365             


Ser Arg His Val Asp Trp Ala Ala Gly Ala Val Glu Leu Val Arg Glu 
    370                 375                 380                 


Asn Gln Pro Trp Pro Gly Thr Asp Arg Pro Arg Arg Ala Gly Val Ser 
385                 390                 395                 400 


Ser Phe Gly Val Ser Gly Thr Asn Ala His Val Ile Leu Glu Ser Ala 
                405                 410                 415     


Pro Pro Ala Gln Pro Ala Glu Glu Ala Gln Pro Val Glu Thr Pro Val 
            420                 425                 430         


Val Ala Ser Asp Val Leu Pro Leu Val Ile Ser Ala Lys Thr Gln Pro 
        435                 440                 445             


Ala Leu Thr Glu His Glu Asp Arg Leu Arg Ala Tyr Leu Ala Ala Ser 
    450                 455                 460                 


Pro Gly Val Asp Thr Arg Ala Val Ala Ser Thr Leu Ala Val Thr Arg 
465                 470                 475                 480 


Ser Val Phe Glu His Arg Ala Val Leu Leu Gly Asp Asp Thr Val Thr 
                485                 490                 495     


Gly Thr Ala Val Ser Asp Pro Arg Val Val Phe Val Phe Pro Gly Gln 
            500                 505                 510         


Gly Trp Gln Trp Leu Gly Met Gly Ser Ala Leu Arg Asp Ser Ser Val 
        515                 520                 525             


Val Phe Ala Glu Arg Met Ala Glu Cys Ala Ala Ala Leu Ser Glu Phe 
    530                 535                 540                 


Val Asp Trp Asp Leu Phe Thr Val Leu Asp Asp Pro Ala Val Val Asp 
545                 550                 555                 560 


Arg Val Asp Val Val Gln Pro Ala Ser Trp Ala Val Met Val Ser Leu 
                565                 570                 575     


Ala Ala Val Trp Gln Ala Ala Gly Val Arg Pro Asp Ala Val Ile Gly 
            580                 585                 590         


His Ser Gln Gly Glu Ile Ala Ala Ala Cys Val Ala Gly Ala Val Ser 
        595                 600                 605             


Leu Arg Asp Ala Ala Arg Ile Val Thr Leu Arg Ser Gln Ala Ile Ala 
    610                 615                 620                 


Gly Leu Ala Gly Arg Gly Ala Met Ala Ser Val Ala Leu Pro Ala Gln 
625                 630                 635                 640 


Asp Val Glu Leu Val Asp Gly Ala Trp Ile Ala Ala His Asn Gly Pro 
                645                 650                 655     


Ala Ser Thr Val Ile Ala Gly Thr Pro Glu Ala Val Asp His Val Leu 
            660                 665                 670         


Thr Ala His Glu Ala Arg Gly Val Arg Val Arg Arg Ile Thr Val Asp 
        675                 680                 685             


Tyr Ala Ser His Thr Pro His Val Glu Leu Ile Arg Asp Glu Leu Leu 
    690                 695                 700                 


Asp Ile Thr Ser Asp Ser Ser Ser Gln Ala Pro Leu Val Pro Trp Leu 
705                 710                 715                 720 


Ser Thr Val Asp Gly Ser Trp Val Asp Ser Pro Leu Asp Gly Glu Tyr 
                725                 730                 735     


Trp Tyr Arg Asn Leu Arg Glu Pro Val Gly Phe His Pro Ala Val Gly 
            740                 745                 750         


Gln Leu Gln Ala Glu Gly Asp Thr Val Phe Val Glu Val Ser Ala Ser 
        755                 760                 765             


Pro Val Leu Leu Gln Ala Met Asp Asp Asp Val Val Thr Val Ala Thr 
    770                 775                 780                 


Leu Arg Arg Asp Asp Gly Asp Ala Thr Arg Met Leu Thr Ala Leu Ala 
785                 790                 795                 800 


Gln Ala Tyr Val His Gly Val Thr Val Asp Trp Pro Ala Ile Leu Gly 
                805                 810                 815     


Thr Ala Thr Thr Arg Val Asp Leu Pro Thr Tyr Ala Phe Gln His Gln 
            820                 825                 830         


Arg Tyr Trp Leu Arg Ser Trp Leu Ala Ala Leu Ala Pro Ala Glu Arg 
        835                 840                 845             


Glu Lys Ala Leu Leu Lys Leu Val Cys Asp Ser Ala Ala Met Val Leu 
    850                 855                 860                 


Gly His Ala Asp Ala Arg Ser Ile Pro Ala Ala Gly Ala Phe Lys Asp 
865                 870                 875                 880 


Leu Gly Val Asp Ser Leu Met Ala Val Glu Leu Arg Asn Gly Leu Val 
                885                 890                 895     


Lys Ala Thr Gly Leu Arg Leu Pro Ala Thr Leu Val Phe Asp Tyr Pro 
            900                 905                 910         


Thr Pro Thr Val Leu Ala Ala Arg Leu Asp 
        915                 920         


<210>  156
<211>  926
<212>  PRT
<213>  Streptomyces rapamycinicus

<400>  156

Glu Pro Leu Ala Ile Val Gly Met Ala Cys Arg Leu Pro Gly Gly Val 
1               5                   10                  15      


Ser Ser Pro Glu Asp Leu Trp Arg Leu Val Glu Ser Gly Thr Asp Ala 
            20                  25                  30          


Val Ser Gly Phe Pro Thr Asp Arg Gly Trp Asp Val Glu Asn Leu Tyr 
        35                  40                  45              


Asp Ser Asp Pro Glu Ala Ala Gly Lys Ser Tyr Cys Val Gln Gly Gly 
    50                  55                  60                  


Phe Leu Asp Thr Ala Ala Gly Phe Asp Ala Gly Phe Phe Gly Ile Ser 
65                  70                  75                  80  


Pro Arg Glu Ala Leu Ala Met Asp Pro Gln Gln Arg Leu Leu Leu Glu 
                85                  90                  95      


Val Ser Trp Glu Ala Phe Glu Arg Ala Gly Ile Glu Pro Gly Ser Val 
            100                 105                 110         


Arg Gly Ser Asp Thr Gly Val Phe Ile Gly Ala Phe Pro Val Gly Tyr 
        115                 120                 125             


Gly Ala Gly Phe Asp Arg Glu Gly Tyr Gly Ala Thr Ser Gly Pro Ser 
    130                 135                 140                 


Val Leu Ser Gly Arg Val Ser Tyr Val Phe Gly Leu Glu Gly Pro Ala 
145                 150                 155                 160 


Ile Thr Met Asp Thr Ala Cys Ser Ser Ser Leu Val Ala Leu His Leu 
                165                 170                 175     


Ala Ala Gln Ala Leu Arg Asn Gly Glu Cys Ser Met Ala Leu Ala Gly 
            180                 185                 190         


Gly Val Thr Val Met Ala Thr Pro Glu Val Phe Thr Glu Phe Ala Arg 
        195                 200                 205             


Gln Arg Gly Leu Ala Ser Asp Gly Arg Cys Lys Ala Phe Ala Asp Ser 
    210                 215                 220                 


Ala Asp Gly Ala Gly Phe Ser Glu Gly Ala Gly Leu Leu Leu Val Glu 
225                 230                 235                 240 


Arg Leu Ser Asp Ala Arg Arg Asn Gly His Gln Val Leu Ala Val Val 
                245                 250                 255     


Arg Gly Ser Ala Val Asn Gln Asp Gly Ala Ser Asn Gly Leu Thr Ala 
            260                 265                 270         


Pro Asn Gly Pro Ser Gln Gln Arg Val Ile Arg Ala Ala Leu Ser Asn 
        275                 280                 285             


Ala Gly Leu Ser Thr Ala Asp Val Asp Val Val Glu Ala His Gly Thr 
    290                 295                 300                 


Gly Thr Thr Leu Gly Asp Pro Ile Glu Ala Gln Ala Leu Leu Ala Thr 
305                 310                 315                 320 


Tyr Gly Gln Asp Arg Glu Gln Pro Leu Leu Leu Gly Ser Leu Lys Ser 
                325                 330                 335     


Asn Ile Gly His Thr Gln Ala Ala Ser Gly Val Ser Gly Val Ile Lys 
            340                 345                 350         


Met Val Met Ala Leu Arg His Gly Phe Val Pro Arg Thr Leu His Val 
        355                 360                 365             


Asp Glu Pro Ser Arg His Val Asp Trp Ala Ala Gly Ala Val Glu Leu 
    370                 375                 380                 


Val Arg Glu Asn Gln Pro Trp Pro Gly Thr Asp Arg Pro Arg Arg Ala 
385                 390                 395                 400 


Gly Val Ser Ser Phe Gly Val Ser Gly Thr Asn Ala His Val Val Leu 
                405                 410                 415     


Glu Ser Ala Pro Pro Ala Gln Pro Ala Glu Glu Glu Gln Pro Val Glu 
            420                 425                 430         


Thr Pro Val Val Ala Ser Asp Val Leu Pro Leu Val Ile Ser Ala Lys 
        435                 440                 445             


Thr Gln Pro Ala Leu Thr Glu His Glu Asp Arg Leu Arg Ala Tyr Leu 
    450                 455                 460                 


Ala Ala Ser Pro Gly Ala Asp Thr Arg Ala Val Ala Ser Thr Leu Ala 
465                 470                 475                 480 


Val Thr Arg Ser Val Phe Glu His Arg Ala Val Leu Leu Gly Asp Asp 
                485                 490                 495     


Ala Val Thr Gly Thr Ala Val Thr Asp Pro Arg Val Val Phe Val Phe 
            500                 505                 510         


Pro Gly Gln Gly Trp Gln Trp Leu Gly Met Gly Ser Ala Leu Arg Asp 
        515                 520                 525             


Ser Ser Val Val Phe Ala Glu Arg Met Ala Glu Cys Ala Ala Ala Leu 
    530                 535                 540                 


Ser Glu Phe Val Asp Trp Asp Leu Phe Ala Val Leu Asp Asp Pro Ala 
545                 550                 555                 560 


Val Val Asp Arg Val Asp Val Val Gln Pro Ala Ser Trp Ala Val Met 
                565                 570                 575     


Val Ser Leu Ala Ala Val Trp Gln Ala Ala Gly Val Arg Pro Asp Ala 
            580                 585                 590         


Val Ile Gly His Ser Gln Gly Glu Ile Ala Ala Ala Cys Val Ala Gly 
        595                 600                 605             


Ala Val Ser Leu Arg Asp Ala Ala Arg Ile Val Thr Leu Arg Ser Gln 
    610                 615                 620                 


Ala Ile Ala Gly Leu Ala Gly Arg Gly Ala Met Ala Ser Val Ala Leu 
625                 630                 635                 640 


Pro Ala His Glu Ile Glu Leu Val Asp Gly Ala Trp Ile Ala Ala His 
                645                 650                 655     


Asn Gly Pro Ala Ser Thr Val Ile Ala Gly Thr Pro Glu Ala Val Asp 
            660                 665                 670         


His Val Leu Thr Ala His Glu Ala Arg Gly Val Arg Val Arg Arg Ile 
        675                 680                 685             


Thr Val Asp Tyr Ala Ser His Thr Pro His Val Glu Leu Ile Arg Asp 
    690                 695                 700                 


Glu Leu Leu Gly Ile Thr Ala Gly Ile Gly Ser Gln Pro Pro Val Val 
705                 710                 715                 720 


Pro Trp Leu Ser Thr Val Asp Gly Ser Trp Val Asp Ser Pro Leu Asp 
                725                 730                 735     


Gly Glu Tyr Trp Tyr Arg Asn Leu Arg Glu Pro Val Gly Phe His Pro 
            740                 745                 750         


Ala Val Ser Gln Leu Gln Ala Gln Gly Asp Ala Val Phe Val Glu Val 
        755                 760                 765             


Ser Ala Ser Pro Val Leu Leu Gln Ala Met Asp Asp Asp Val Val Thr 
    770                 775                 780                 


Val Ala Thr Leu Arg Arg Asp Asp Gly Asp Ala Thr Arg Met Leu Thr 
785                 790                 795                 800 


Ala Leu Ala Gln Ala Tyr Val His Gly Val Thr Val Asp Trp Pro Ala 
                805                 810                 815     


Ile Leu Gly Thr Thr Thr Ala Arg Val Leu Asp Leu Pro Thr Tyr Ala 
            820                 825                 830         


Phe Gln His Gln Arg Tyr Trp Val Lys Ser Trp Leu Ala Ala Leu Ala 
        835                 840                 845             


Pro Glu Glu Arg Ala Lys Ala Leu Leu Arg Val Val Cys Asp Ser Ala 
    850                 855                 860                 


Ala Thr Val Leu Gly His Ala Asp Ile Asp Ser Ile Pro Val Thr Ala 
865                 870                 875                 880 


Ala Phe Lys Asp Leu Gly Val Asp Ser Leu Thr Ala Val Glu Leu Arg 
                885                 890                 895     


Asn Ser Leu Ala Lys Ala Thr Gly Leu Arg Leu Pro Ala Thr Leu Val 
            900                 905                 910         


Phe Asp Tyr Pro Thr Pro Thr Ala Leu Ala Ala Arg Leu Asp 
        915                 920                 925     


<210>  157
<211>  902
<212>  PRT
<213>  Streptomyces rapamycinicus

<400>  157

Glu Pro Leu Ala Ile Val Gly Met Ala Cys Arg Leu Pro Gly Gly Val 
1               5                   10                  15      


Ser Ser Pro Glu Asp Leu Trp Arg Leu Val Glu Ser Gly Thr Asp Ala 
            20                  25                  30          


Ile Ser Asp Phe Pro Ala Asp Arg Gly Trp Asp Val Glu Asn Leu Tyr 
        35                  40                  45              


Asp Pro Asp Pro Asp Ala Ser Gly Lys Ser Tyr Cys Val Gln Gly Gly 
    50                  55                  60                  


Phe Leu Asp Ser Ala Gly Gly Phe Asp Ala Ser Phe Phe Gly Ile Ser 
65                  70                  75                  80  


Pro Arg Glu Ala Leu Ala Met Asp Pro Gln Gln Arg Leu Val Leu Glu 
                85                  90                  95      


Val Ser Trp Glu Ala Phe Glu Arg Ala Gly Ile Glu Pro Gly Ser Leu 
            100                 105                 110         


Arg Gly Ser Asp Thr Gly Val Phe Ile Gly Ala Tyr Pro Gly Gly Tyr 
        115                 120                 125             


Gly Ala Gly Ala Gly Ala Asp Leu Glu Gly Tyr Gly Thr Thr Ser Gly 
    130                 135                 140                 


Pro Ser Val Leu Ser Gly Arg Val Ser Tyr Phe Phe Gly Leu Glu Gly 
145                 150                 155                 160 


Pro Ala Ile Thr Val Asp Thr Ala Cys Ser Ser Ser Leu Val Ala Leu 
                165                 170                 175     


His Gln Ala Gly Tyr Ala Leu Arg Gln Gly Glu Cys Ser Leu Ala Leu 
            180                 185                 190         


Val Gly Gly Val Thr Val Met Ala Thr Pro Asp Val Phe Thr Glu Phe 
        195                 200                 205             


Ala Arg Gln Arg Gly Leu Ala Thr Asp Gly Arg Ser Lys Ala Phe Ala 
    210                 215                 220                 


Asp Ser Ala Asp Gly Ala Gly Phe Ser Glu Gly Ile Gly Val Leu Leu 
225                 230                 235                 240 


Val Glu Arg Leu Ser Asp Ala Glu Ala Lys Gly His Gln Val Leu Ala 
                245                 250                 255     


Val Val Arg Ser Ser Ala Val Asn Gln Asp Gly Ala Ser Asn Gly Leu 
            260                 265                 270         


Thr Ala Pro Asn Gly Pro Ser Gln Gln Arg Val Ile Gln Thr Ala Leu 
        275                 280                 285             


Ser Asn Ala Gly Leu Thr Thr Ala Glu Val Asp Val Val Glu Gly His 
    290                 295                 300                 


Gly Thr Gly Thr Thr Leu Gly Asp Pro Ile Glu Ala Gln Ala Val Ile 
305                 310                 315                 320 


Ala Thr Tyr Gly Gln Asp Arg Glu Gln Pro Leu Leu Leu Gly Ser Leu 
                325                 330                 335     


Lys Ser Asn Ile Gly His Thr Gln Ala Ala Ala Gly Val Ser Gly Val 
            340                 345                 350         


Ile Lys Met Val Met Ala Leu Arg His Ala Leu Val Pro Arg Thr Leu 
        355                 360                 365             


His Val Asp Glu Pro Ser Arg His Val Asp Trp Thr Ala Gly Ala Val 
    370                 375                 380                 


Glu Leu Val Thr Glu Asn Gln Pro Trp Pro Glu Ile Gly Arg Pro Arg 
385                 390                 395                 400 


Arg Ala Gly Val Ser Ser Phe Gly Val Ser Gly Thr Asn Ala His Val 
                405                 410                 415     


Ile Leu Glu Ser Ala Pro Pro Thr Gln Ala Glu Asp Ala Ala Gln Pro 
            420                 425                 430         


Val Glu Ala Pro Val Met Gly Ser Glu Pro Val Pro Leu Val Ile Ser 
        435                 440                 445             


Ala Lys Thr Leu Pro Ala Leu Asn Ala His Glu Asp Arg Leu Arg Ala 
    450                 455                 460                 


Tyr Leu Ala Ala Ser Pro Gly Val Asp Met Arg Ala Val Ala Ser Thr 
465                 470                 475                 480 


Leu Ala Met Thr Arg Ser Met Phe Glu His Arg Gly Val Leu Leu Gly 
                485                 490                 495     


Asp Gly Thr Val Ser Gly Thr Ala Val Ser Asp Pro Arg Val Val Phe 
            500                 505                 510         


Val Phe Pro Gly Gln Gly Ser Gln Arg Ala Gly Met Gly Glu Glu Leu 
        515                 520                 525             


Ala Ala Ala Phe Pro Val Phe Ala Arg Ile His Gln Gln Val Trp Asp 
    530                 535                 540                 


Leu Leu Asp Val Pro Asp Leu Asp Val Asn Glu Thr Gly Tyr Ala Gln 
545                 550                 555                 560 


Pro Ala Leu Phe Ala Leu Gln Val Ala Leu Phe Gly Leu Leu Glu Ser 
                565                 570                 575     


Trp Gly Val Arg Pro Asp Ala Val Ile Gly His Ser Val Gly Glu Leu 
            580                 585                 590         


Ala Ala Ala Tyr Val Ser Gly Val Trp Ser Leu Glu Asp Ala Cys Thr 
        595                 600                 605             


Leu Val Ser Ala Arg Ala Arg Leu Met Gln Ala Leu Pro Ala Gly Gly 
    610                 615                 620                 


Val Met Val Ala Val Pro Val Ser Glu Asp Glu Ala Arg Ala Val Leu 
625                 630                 635                 640 


Gly Glu Gly Val Glu Ile Ala Ala Val Asn Gly Pro Ser Ser Val Val 
                645                 650                 655     


Leu Ser Gly Asp Glu Ala Ala Val Leu Gln Ala Ala Glu Gly Leu Gly 
            660                 665                 670         


Lys Trp Thr Arg Leu Ala Thr Ser His Ala Phe His Ser Ala Arg Met 
        675                 680                 685             


Glu Pro Met Leu Glu Glu Phe Arg Ala Val Ala Glu Gly Leu Thr Tyr 
    690                 695                 700                 


Arg Thr Pro Gln Val Ala Met Ala Ala Gly Asp Gln Val Met Thr Ala 
705                 710                 715                 720 


Glu Tyr Trp Val Arg Gln Val Arg Asp Thr Val Arg Phe Gly Glu Gln 
                725                 730                 735     


Val Ala Ser Phe Glu Asp Ala Val Phe Val Glu Leu Gly Ala Asp Arg 
            740                 745                 750         


Ser Leu Ala Arg Leu Val Asp Gly Val Ala Met Leu His Gly Asp His 
        755                 760                 765             


Glu Ala Gln Ala Ala Val Gly Ala Leu Ala His Leu Tyr Val Asn Gly 
    770                 775                 780                 


Val Ser Val Glu Trp Ser Ala Val Leu Gly Asp Val Pro Val Thr Arg 
785                 790                 795                 800 


Val Asp Leu Pro Thr Tyr Ala Phe Gln His Gln Arg Tyr Trp Leu Glu 
                805                 810                 815     


Gly Arg Trp Leu Ala Ala Leu Ala Pro Ala Glu Arg Glu Lys Ala Leu 
            820                 825                 830         


Leu Lys Leu Val Ser Asp Gly Ala Ala Thr Val Leu Gly His Ala Asp 
        835                 840                 845             


Thr Ser Thr Ile Pro Ala Thr Thr Ala Phe Lys Asp Leu Gly Ile Asn 
    850                 855                 860                 


Ser Leu Thr Ala Val Glu Leu Arg Asn Ser Leu Ala Lys Ala Thr Glu 
865                 870                 875                 880 


Leu Arg Leu Pro Ala Thr Leu Val Phe Asp Tyr Pro Thr Pro Ala Ala 
                885                 890                 895     


Leu Ala Ala Arg Leu Asp 
            900         


<210>  158
<211>  892
<212>  PRT
<213>  Streptomyces rapamycinicus

<400>  158

Glu Pro Leu Ala Ile Val Gly Met Ala Cys Arg Leu Pro Gly Gly Val 
1               5                   10                  15      


Ser Ser Pro Glu Asp Leu Trp Arg Leu Leu Glu Ser Gly Thr Asp Ala 
            20                  25                  30          


Val Ser Gly Phe Pro Thr Asp Arg Gly Trp Asp Val Glu Asn Leu Tyr 
        35                  40                  45              


Asp Met Ala Gly Lys Ser His Arg Ala Glu Gly Gly Phe Leu Asp Ala 
    50                  55                  60                  


Ala Ala Gly Phe Asp Ala Gly Phe Phe Gly Ile Ser Pro Arg Glu Ala 
65                  70                  75                  80  


Leu Ala Met Asp Pro Gln Gln Arg Leu Val Leu Glu Val Ser Trp Glu 
                85                  90                  95      


Ala Phe Glu Arg Ala Gly Ile Glu Pro Gly Ser Val Arg Gly Ser Asp 
            100                 105                 110         


Thr Gly Val Phe Met Gly Ala Tyr Pro Gly Gly Tyr Gly Ile Gly Ala 
        115                 120                 125             


Asp Leu Gly Gly Phe Gly Ala Thr Ala Ser Ser Val Ser Val Leu Ser 
    130                 135                 140                 


Gly Arg Val Ser Tyr Phe Phe Gly Leu Glu Gly Pro Ala Phe Thr Val 
145                 150                 155                 160 


Asp Thr Ala Cys Ser Ser Ser Leu Val Ala Leu His Gln Ala Gly Tyr 
                165                 170                 175     


Ala Leu Arg Gln Gly Glu Cys Ser Leu Ala Leu Val Gly Gly Val Thr 
            180                 185                 190         


Val Met Ala Thr Pro Gln Thr Phe Val Glu Phe Ser Arg Gln Gly Gly 
        195                 200                 205             


Leu Ala Ser Asp Gly Arg Cys Lys Ala Phe Ala Asp Ala Ala Asp Gly 
    210                 215                 220                 


Thr Gly Trp Ala Glu Gly Val Gly Val Leu Leu Val Glu Arg Leu Ser 
225                 230                 235                 240 


Asp Ala Arg Arg Asn Gly His Gln Val Leu Ala Val Val Arg Gly Ser 
                245                 250                 255     


Ala Val Asn Gln Asp Gly Ala Ser Asn Gly Leu Thr Ala Pro Asn Gly 
            260                 265                 270         


Pro Ser Gln Gln Arg Val Ile Arg Ala Ala Leu Ser Asn Ala Gly Leu 
        275                 280                 285             


Ser Thr Ala Glu Val Asp Val Val Glu Ala His Gly Thr Gly Thr Thr 
    290                 295                 300                 


Leu Gly Asp Pro Ile Glu Ala Gln Ala Leu Ile Ala Thr Tyr Gly Gln 
305                 310                 315                 320 


Asp Arg Asp Gln Pro Val Leu Leu Gly Ser Val Lys Ser Asn Leu Gly 
                325                 330                 335     


His Thr Gln Ala Ala Ala Gly Val Ser Gly Val Ile Lys Met Val Met 
            340                 345                 350         


Ala Leu Gln His Gly Leu Val Pro Arg Thr Leu His Val Asp Glu Pro 
        355                 360                 365             


Ser Arg His Val Asp Trp Ser Ala Gly Ala Val Gln Leu Val Thr Glu 
    370                 375                 380                 


Asn Gln Pro Trp Pro Asp Met Gly Arg Ala Arg Arg Ala Gly Val Ser 
385                 390                 395                 400 


Ser Phe Gly Ile Ser Gly Thr Asn Ala His Val Ile Leu Glu Ser Ala 
                405                 410                 415     


Pro Pro Thr Gln Pro Ala Asp Asn Ala Val Ile Glu Arg Ala Pro Glu 
            420                 425                 430         


Trp Val Pro Leu Val Ile Ser Ala Arg Thr Gln Ser Ala Leu Thr Glu 
        435                 440                 445             


His Glu Gly Arg Leu Arg Ala Tyr Leu Ala Ala Ser Pro Gly Val Asp 
    450                 455                 460                 


Met Arg Ala Val Ala Ser Thr Leu Ala Met Thr Arg Ser Val Phe Glu 
465                 470                 475                 480 


His Arg Ala Val Leu Leu Gly Asp Asp Thr Val Thr Gly Thr Ala Val 
                485                 490                 495     


Ser Asp Pro Arg Ala Val Phe Val Phe Pro Gly Gln Gly Ser Gln Arg 
            500                 505                 510         


Ala Gly Met Gly Glu Glu Leu Ala Ala Ala Phe Pro Val Phe Ala Arg 
        515                 520                 525             


Ile His Gln Gln Val Trp Asp Leu Leu Asp Val Pro Asp Leu Glu Val 
    530                 535                 540                 


Asn Glu Thr Gly Tyr Ala Gln Pro Ala Leu Phe Ala Met Gln Val Ala 
545                 550                 555                 560 


Leu Phe Gly Leu Leu Glu Ser Trp Gly Val Arg Pro Asp Ala Val Ile 
                565                 570                 575     


Gly His Ser Val Gly Glu Leu Ala Ala Ala Tyr Val Ser Gly Val Trp 
            580                 585                 590         


Ser Leu Glu Asp Ala Cys Thr Leu Val Ser Ala Arg Ala Arg Leu Met 
        595                 600                 605             


Gln Ala Leu Pro Ala Gly Gly Val Met Val Ala Val Pro Val Ser Glu 
    610                 615                 620                 


Asp Glu Ala Arg Ala Val Leu Gly Glu Gly Val Glu Ile Ala Ala Val 
625                 630                 635                 640 


Asn Gly Pro Ser Ser Val Val Leu Ser Gly Asp Glu Ala Ala Val Leu 
                645                 650                 655     


Gln Ala Ala Glu Gly Leu Gly Lys Trp Thr Arg Leu Ala Thr Ser His 
            660                 665                 670         


Ala Phe His Ser Ala Arg Met Glu Pro Met Leu Glu Glu Phe Arg Ala 
        675                 680                 685             


Val Ala Glu Gly Leu Thr Tyr Arg Thr Pro Gln Val Ser Met Ala Val 
    690                 695                 700                 


Gly Asp Gln Val Thr Thr Ala Glu Tyr Trp Val Arg Gln Val Arg Asp 
705                 710                 715                 720 


Thr Val Arg Phe Gly Glu Gln Val Ala Ser Tyr Glu Asp Ala Val Phe 
                725                 730                 735     


Val Glu Leu Gly Ala Asp Arg Ser Leu Ala Arg Leu Val Asp Gly Val 
            740                 745                 750         


Ala Met Leu His Gly Asp His Glu Ile Gln Ala Ala Ile Gly Ala Leu 
        755                 760                 765             


Ala His Leu Tyr Val Asn Gly Val Thr Val Asp Trp Pro Ala Leu Leu 
    770                 775                 780                 


Gly Asp Ala Pro Ala Thr Arg Val Asp Leu Pro Thr Tyr Ala Phe Gln 
785                 790                 795                 800 


His Gln Arg Tyr Trp Leu Glu Gly Arg Trp Leu Ala Ala Leu Ala Pro 
                805                 810                 815     


Ala Glu Arg Glu Asp Ala Leu Leu Lys Leu Val Arg Asp Ser Ala Ala 
            820                 825                 830         


Leu Val Leu Gly His Ala Asp Ala Ser Thr Ile Pro Ala Ala Ala Ala 
        835                 840                 845             


Phe Lys Asp Leu Gly Ile Asp Ser Leu Thr Ala Val Glu Leu Arg Asn 
    850                 855                 860                 


Ser Leu Ala Lys Ala Thr Gly Leu Arg Leu Pro Asn Thr Thr Val Phe 
865                 870                 875                 880 


Asp Tyr Pro Thr Pro Ala Ile Leu Ala Thr Arg Leu 
                885                 890         


<210>  159
<211>  924
<212>  PRT
<213>  Streptomyces rapamycinicus

<400>  159

Glu Pro Leu Ala Val Val Gly Met Ala Cys Arg Leu Pro Gly Gly Val 
1               5                   10                  15      


Ser Ser Pro Glu Asp Leu Trp Arg Leu Val Glu Ser Gly Thr Asp Ala 
            20                  25                  30          


Ile Ser Gly Phe Pro Ala Asp Arg Gly Trp Asp Ala Glu Ser Leu Phe 
        35                  40                  45              


Asp Pro Asp Pro Ala Val Gly Lys Ser Tyr Cys Val Glu Gly Gly Phe 
    50                  55                  60                  


Leu Asp Ser Ala Ala Ser Phe Asp Ala Gly Phe Phe Gly Ile Ser Pro 
65                  70                  75                  80  


Arg Glu Ala Leu Ala Met Asp Pro Gln Gln Arg Leu Ile Met Glu Val 
                85                  90                  95      


Ser Trp Glu Ala Phe Glu Arg Ala Gly Ile Glu Pro Gly Ser Val Arg 
            100                 105                 110         


Gly Ser Asp Thr Gly Val Phe Met Gly Ala Tyr Ala Gly Gly Tyr Gly 
        115                 120                 125             


Ala Gly Ala Asp Leu Gly Gly Phe Ala Ala Thr Ala Ser Ala Thr Ser 
    130                 135                 140                 


Val Leu Ser Gly Arg Val Ser Tyr Phe Phe Gly Leu Glu Gly Pro Ala 
145                 150                 155                 160 


Ile Thr Val Asp Thr Ala Cys Ser Ser Ser Leu Val Ala Leu His Gln 
                165                 170                 175     


Ala Gly Tyr Ala Leu Arg Gln Gly Glu Cys Ser Leu Ala Leu Val Gly 
            180                 185                 190         


Gly Val Thr Val Met Ala Thr Pro Gln Ser Phe Val Glu Phe Ser Arg 
        195                 200                 205             


Gln Arg Gly Leu Ala Ser Asp Gly Arg Cys Lys Ala Phe Ala Asp Ser 
    210                 215                 220                 


Ala Asp Gly Thr Gly Trp Ala Glu Gly Val Gly Val Leu Leu Val Glu 
225                 230                 235                 240 


Arg Leu Ser Asp Ala Gln Ala Lys Gly His Gln Val Leu Ala Val Val 
                245                 250                 255     


Arg Ser Ser Ala Val Asn Gln Asp Gly Ala Ser Asn Gly Leu Thr Ala 
            260                 265                 270         


Pro Asn Gly Pro Ser Gln Gln Arg Val Ile Gln Ala Ala Leu Ser Asn 
        275                 280                 285             


Ala Gly Leu Ala Ala His Glu Val Asp Val Val Glu Ala His Gly Thr 
    290                 295                 300                 


Gly Thr Thr Leu Gly Asp Pro Ile Glu Ala Gln Ala Leu Ile Ala Thr 
305                 310                 315                 320 


Tyr Gly Gln Asp Arg Glu Arg Pro Leu Leu Leu Gly Ser Leu Lys Ser 
                325                 330                 335     


Asn Ile Gly His Ala Gln Ala Ala Ser Gly Val Ser Gly Val Ile Lys 
            340                 345                 350         


Met Val Met Ala Leu Gln His Asn Thr Val Pro Arg Thr Leu His Val 
        355                 360                 365             


Asp Glu Pro Ser Arg His Val Asp Trp Ala Ala Gly Ala Val Glu Leu 
    370                 375                 380                 


Val Arg Glu Asn Gln Pro Trp Pro Gly Thr Asp Arg Pro Arg Arg Ala 
385                 390                 395                 400 


Gly Val Ser Ser Phe Gly Val Ser Gly Thr Asn Ala His Val Ile Leu 
                405                 410                 415     


Glu Ser Ala Pro Pro Ala Gln Pro Ala Glu Glu Ala Gln Pro Val Glu 
            420                 425                 430         


Thr Pro Val Val Ala Ser Asp Val Leu Pro Leu Val Ile Ser Ala Lys 
        435                 440                 445             


Thr Gln Pro Ala Leu Thr Glu His Glu Asp Arg Leu Arg Ala Tyr Leu 
    450                 455                 460                 


Ala Ala Ser Pro Gly Ala Asp Ile Arg Ala Val Ala Ser Thr Leu Ala 
465                 470                 475                 480 


Val Thr Arg Ser Val Phe Glu His Arg Ala Val Leu Leu Gly Asp Asp 
                485                 490                 495     


Thr Val Thr Gly Thr Ala Val Thr Asp Pro Arg Ile Val Phe Val Phe 
            500                 505                 510         


Pro Gly Gln Gly Trp Gln Trp Leu Gly Met Gly Ser Ala Leu Arg Asp 
        515                 520                 525             


Ser Ser Val Val Phe Ala Glu Arg Met Ala Glu Cys Ala Ala Ala Leu 
    530                 535                 540                 


Arg Glu Phe Val Asp Trp Asp Leu Phe Thr Val Leu Asp Asp Pro Ala 
545                 550                 555                 560 


Val Val Asp Arg Val Asp Val Val Gln Pro Ala Ser Trp Ala Met Met 
                565                 570                 575     


Val Ser Leu Ala Ala Val Trp Gln Ala Ala Gly Val Arg Pro Asp Ala 
            580                 585                 590         


Val Ile Gly His Ser Gln Gly Glu Ile Ala Ala Ala Cys Val Ala Gly 
        595                 600                 605             


Ala Val Ser Leu Arg Asp Ala Ala Arg Ile Val Thr Leu Arg Ser Gln 
    610                 615                 620                 


Ala Ile Ala Gly Leu Ala Gly Arg Gly Ala Met Ala Ser Val Ala Leu 
625                 630                 635                 640 


Pro Ala Gln Asp Val Glu Leu Val Asp Gly Ala Trp Ile Ala Ala His 
                645                 650                 655     


Asn Gly Pro Ala Ser Thr Val Ile Ala Gly Thr Pro Glu Ala Val Asp 
            660                 665                 670         


His Val Leu Thr Ala His Glu Ala Gln Gly Val Arg Val Arg Arg Ile 
        675                 680                 685             


Thr Val Asp Tyr Ala Ser His Thr Pro His Val Glu Leu Ile Arg Asp 
    690                 695                 700                 


Glu Leu Leu Asp Ile Thr Ser Asp Ser Ser Ser Gln Thr Pro Leu Val 
705                 710                 715                 720 


Pro Trp Leu Ser Thr Val Asp Gly Thr Trp Val Asp Ser Pro Leu Asp 
                725                 730                 735     


Gly Glu Tyr Trp Tyr Arg Asn Leu Arg Glu Pro Val Gly Phe His Pro 
            740                 745                 750         


Ala Val Ser Gln Leu Gln Ala Gln Gly Asp Thr Val Phe Val Glu Val 
        755                 760                 765             


Ser Ala Ser Pro Val Leu Leu Gln Ala Met Asp Asp Asp Val Val Thr 
    770                 775                 780                 


Val Ala Thr Leu Arg Arg Asp Asp Gly Asp Ala Thr Arg Met Leu Thr 
785                 790                 795                 800 


Ala Leu Ala Gln Ala Tyr Val His Gly Val Thr Val Asp Trp Pro Ala 
                805                 810                 815     


Ile Leu Gly Thr Thr Thr Thr Arg Val Asp Leu Pro Thr Tyr Ala Phe 
            820                 825                 830         


Gln His Gln Arg Tyr Trp Leu Lys Ser Arg Leu Thr Gly Arg Thr Ser 
        835                 840                 845             


Val Glu Gln His Arg Ile Met Leu Glu Leu Val Leu Gly Glu Ala Ala 
    850                 855                 860                 


Ser Val Leu Gly His Ser Ser Ala Asp Ala Ile Ala Thr Asp Thr Ser 
865                 870                 875                 880 


Phe Lys Asp Leu Gly Met Asp Ser Leu Thr Ala Ile Glu Leu Arg Asn 
                885                 890                 895     


Arg Leu Val Ala Glu Thr Gly Leu Gln Leu Pro Ala Thr Met Val Phe 
            900                 905                 910         


Asp Tyr Pro Thr Ala Asn Ala Leu Ala Ala His Leu 
        915                 920                 


<210>  160
<211>  966
<212>  PRT
<213>  Streptomyces rapamycinicus

<400>  160

Glu Pro Ile Ala Ile Val Ala Met Ala Cys Arg Leu Pro Gly Gly Val 
1               5                   10                  15      


Ser Ser Pro Glu Gly Leu Trp His Leu Val Glu Ser Gly Thr Asp Ala 
            20                  25                  30          


Ile Ser Gly Phe Pro Thr Asp Arg Gly Trp Asp Val Glu Gly Leu Phe 
        35                  40                  45              


Asp Pro Asp Pro Asp Ala Ala Gly Lys Ser Tyr Cys Val Gln Gly Gly 
    50                  55                  60                  


Phe Leu Asp Thr Ala Ala Asp Phe Asp Ala Pro Phe Phe Gly Ile Ser 
65                  70                  75                  80  


Pro Arg Glu Ala Leu Gly Met Asp Pro Gln Gln Arg Leu Leu Leu Glu 
                85                  90                  95      


Thr Thr Trp Glu Ala Ile Glu Arg Ala Gln Ile Asp Pro Lys Ser Leu 
            100                 105                 110         


Arg Gly Arg Asp Val Gly Val Tyr Val Gly Gly Ala Ala Gln Gly Tyr 
        115                 120                 125             


Gly Val Gly Val Asp Gln Gln His Asp Asn Gly Ile Thr Gly Ser Ser 
    130                 135                 140                 


Val Ser Leu Leu Ser Gly Arg Val Ser Tyr Ala Leu Gly Leu Glu Gly 
145                 150                 155                 160 


Pro Gly Val Thr Val Asp Thr Ala Cys Ser Ser Ser Leu Val Ala Leu 
                165                 170                 175     


His Leu Ala Ser Gln Ala Leu Arg Gln Arg Glu Cys Ser Leu Ala Leu 
            180                 185                 190         


Val Ser Gly Val Ser Val Met Ser Ser Pro Ala Met Phe Val Glu Phe 
        195                 200                 205             


Ser Arg Gln Arg Gly Leu Ser Ser Asp Gly Arg Cys Lys Ser Phe Ala 
    210                 215                 220                 


Ala Ser Ala Asp Gly Thr Ile Trp Ser Glu Gly Val Gly Val Leu Val 
225                 230                 235                 240 


Val Glu Arg Leu Ser Asp Ala Arg Arg Leu Gly His Arg Val Leu Ala 
                245                 250                 255     


Thr Val Arg Gly Ser Ala Val Asn Ser Asp Gly Ala Ser Asn Gly Leu 
            260                 265                 270         


Thr Ala Pro Asn Gly Thr Ser Gln Gln Arg Val Ile Arg Gln Ala Leu 
        275                 280                 285             


Ala Asn Ala Gly Leu Thr Ala Ser Asp Val Asp Val Val Glu Ala His 
    290                 295                 300                 


Gly Thr Gly Thr Lys Leu Gly Asp Pro Ile Glu Ala Glu Ala Ile Leu 
305                 310                 315                 320 


Ala Thr Tyr Gly Gln Glu Arg Ser Ala Pro Ala Trp Leu Gly Ser Leu 
                325                 330                 335     


Lys Ser Asn Ile Gly His Ala Met Ala Ala Ser Gly Val Leu Ser Val 
            340                 345                 350         


Ile Lys Met Val Glu Ala Met Gly His Gly Ser Leu Pro Arg Thr Leu 
        355                 360                 365             


His Val Asp Ala Pro Ser Pro His Val Asp Trp Thr Ser Gly Ser Val 
    370                 375                 380                 


Ala Leu Leu Thr Glu His Gln Pro Trp Pro Asp Asp Thr Lys Leu Arg 
385                 390                 395                 400 


Arg Ala Gly Val Ser Ser Phe Gly Leu Ser Gly Thr Asn Ala His Val 
                405                 410                 415     


Val Leu Glu Gln Tyr Gln Ala Pro Ala Pro Pro Val Thr Pro Val Thr 
            420                 425                 430         


Pro Ala Pro Pro Thr Pro Val Thr Pro Val Thr Pro Asn Glu Pro Gly 
        435                 440                 445             


Pro Leu Pro Trp Val Leu Ser Ala Gln Ser Pro Lys Ala Leu Arg Glu 
    450                 455                 460                 


Gln Ala Gly Arg Leu Tyr Ala Ser Leu Ala Gly Asp Ser Glu Trp Asn 
465                 470                 475                 480 


Ser Leu Asp Ile Gly Tyr Ser Leu Ala Thr Thr Arg Ser Asp Phe Ala 
                485                 490                 495     


His Arg Ala Val Ala Val Gly Ser Gly Arg Glu Phe Leu Arg Ala Leu 
            500                 505                 510         


Ser Lys Leu Ala Asp Gly Ala Pro Trp Pro Gly Leu Thr Thr Ala Thr 
        515                 520                 525             


Ala Thr Ala Lys Ala Arg Arg Val Ala Phe Leu Phe Asp Gly Gln Gly 
    530                 535                 540                 


Thr Gln Arg Leu Gly Met Gly Lys Glu Leu Tyr Asp Ser Tyr Pro Ala 
545                 550                 555                 560 


Phe Ala Arg Ala Trp Asp Thr Val Ser Ala Gly Phe Asp Lys His Leu 
                565                 570                 575     


Asp His Ser Leu Thr Asp Val Cys Phe Gly Glu Gly Gly Ser Thr Thr 
            580                 585                 590         


Ala Gly Leu Val Asp Asp Thr Leu Tyr Ala Gln Ala Gly Ile Phe Ala 
        595                 600                 605             


Met Glu Ala Ala Leu Phe Gly Leu Leu Glu Asp Trp Gly Val Arg Pro 
    610                 615                 620                 


Asp Phe Val Ala Gly His Ser Ile Gly Glu Ala Thr Ala Ala Tyr Ala 
625                 630                 635                 640 


Ser Gly Met Leu Ser Leu Glu Asn Val Thr Thr Leu Ile Val Ala Arg 
                645                 650                 655     


Gly Arg Ala Leu Arg Thr Thr Pro Pro Gly Ala Met Val Ala Leu Arg 
            660                 665                 670         


Ala Gly Glu Glu Glu Val Arg Glu Phe Leu Ser Arg Thr Gly Ala Ala 
        675                 680                 685             


Leu Asp Leu Ala Ala Val Asn Ser Pro Glu Ala Val Val Val Ser Gly 
    690                 695                 700                 


Glu Pro Glu Pro Val Ala Asp Phe Glu Ala Ala Trp Thr Ala Ser Gly 
705                 710                 715                 720 


Arg Glu Ala Arg Lys Leu Lys Val Arg His Ala Phe His Ser Arg His 
                725                 730                 735     


Val Glu Ala Val Leu Asp Glu Phe Arg Thr Ala Leu Glu Ser Leu Lys 
            740                 745                 750         


Phe Arg Ala Pro Ala Leu Pro Val Val Ser Thr Val Thr Gly Arg Leu 
        755                 760                 765             


Ile Asp Gln Asp Glu Met Gly Thr Pro Glu Tyr Trp Leu Arg Gln Val 
    770                 775                 780                 


Arg Arg Pro Val Arg Phe Gln Asp Ala Val Arg Glu Leu Ala Glu Gln 
785                 790                 795                 800 


Gly Val Gly Thr Phe Val Glu Val Gly Pro Ser Gly Ala Leu Ala Ser 
                805                 810                 815     


Ala Gly Val Glu Cys Leu Gly Gly Asp Ala Ser Phe His Ala Val Leu 
            820                 825                 830         


Arg Pro Arg Ser Pro Glu Asp Val Cys Leu Met Thr Ala Ile Ala Glu 
        835                 840                 845             


Leu His Ala Gly Gly Thr Ala Ile Asp Trp Ala Lys Val Leu Ser Gly 
    850                 855                 860                 


Gly Arg Ala Val Asp Leu Pro Val Tyr Pro Phe Gln His Gln Ser Tyr 
865                 870                 875                 880 


Trp Leu Ala Pro Ala Glu Pro Ser Tyr Ala Asp Glu Pro Arg Thr Met 
                885                 890                 895     


Leu Glu Leu Val His Met Glu Val Ala Ser Leu Leu Gly Met Ala Asp 
            900                 905                 910         


Pro Gly Val Ile Leu Asp Asp Ser Ser Phe Leu Glu Leu Gly Phe Asp 
        915                 920                 925             


Ser Leu Ser Ala Val Arg Leu Arg Asn Arg Leu Ser Lys Ala Thr Gly 
    930                 935                 940                 


Leu Asp Leu Pro Ser Thr Leu Leu Phe Glu His Pro Thr Ser Ala Glu 
945                 950                 955                 960 


Leu Ala Ala His Leu Asp 
                965     


<210>  161
<211>  1297
<212>  PRT
<213>  Streptomyces violaceusniger

<400>  161

Met Ser Arg Ala Glu Leu Val Arg Pro Ile Tyr Asp Leu Leu Arg Ala 
1               5                   10                  15      


Asn Ala Glu Arg Leu Gly Asp Lys Met Ala Tyr Val Asp Ser Arg Leu 
            20                  25                  30          


Ala Leu Thr His Ala Glu Leu Ala Ala Arg Thr Gly Arg Ile Ala Gly 
        35                  40                  45              


His Leu Val Asp Met Gly Val Asp Arg Gly Asp Arg Val Ala Ile Leu 
    50                  55                  60                  


Leu Gly Asn Arg Val Glu Asn Ile Glu Ser Tyr Leu Ala Ile Ala Arg 
65                  70                  75                  80  


Ala Ser Ala Val Ala Val Pro Leu Asn Pro Asp Ala Thr Glu Ala Glu 
                85                  90                  95      


Val Ala His Phe Leu Ser Asp Ser Gly Ala Val Val Val Ile Thr Asp 
            100                 105                 110         


Ser Ala His Leu Asp Asp Val Arg Arg Thr Ala Pro Ala Val Thr Ile 
        115                 120                 125             


Val Leu Val Gly Glu Glu Arg Ile Pro Pro Gly Val Arg Ser Phe Ala 
    130                 135                 140                 


Glu Leu Ala Thr Ala Glu Pro Gln Gln Ser Ala Arg Asp Asp Leu Gly 
145                 150                 155                 160 


Leu Asp Glu Ala Ala Trp Met Leu Tyr Thr Ser Gly Thr Thr Gly Thr 
                165                 170                 175     


Pro Lys Gly Val Leu Ser Thr Gln Gly Ser Gly Leu Trp Ser Ala Ala 
            180                 185                 190         


Tyr Cys Asp Ile Pro Ala Trp Glu Leu Thr Glu Asn Asp Val Leu Leu 
        195                 200                 205             


Trp Pro Ala Pro Leu Phe His Ser Leu Ala Leu His Leu Cys Val Leu 
    210                 215                 220                 


Ala Thr Thr Ala Val Gly Ala Thr Ala Arg Ile Met Asn Gly Phe Val 
225                 230                 235                 240 


Ala Ser Glu Val Leu Glu Glu Leu Thr Glu His Pro Cys Thr Val Leu 
                245                 250                 255     


Val Gly Val Pro Thr Met Phe Arg Tyr Leu Leu Gly Ala Ala Asp Thr 
            260                 265                 270         


Phe Glu Pro Arg Thr Ser Ser Leu Lys Met Gly Leu Val Ala Gly Ser 
        275                 280                 285             


Val Ala Pro Ala Ser Leu Ile Glu Gly Phe Glu Asp Val Phe Gly Val 
    290                 295                 300                 


Pro Leu Leu Asp Thr Tyr Gly Cys Thr Glu Thr Ser Gly Ser Leu Thr 
305                 310                 315                 320 


Val Asn Trp Leu Ser Gly Glu Arg Val Pro Gly Ser Cys Gly Leu Pro 
                325                 330                 335     


Val Pro Gly Leu Ser Leu Arg Phe Val Asp Pro Ile Ser Gly Ala Asp 
            340                 345                 350         


Val Ala Asp Gly Glu Glu Gly Glu Leu Trp Ala Ser Gly Pro Ser Ile 
        355                 360                 365             


Met Ile Gly Tyr His Glu Gln Pro Glu Ala Thr Ala Glu Val Leu Ser 
    370                 375                 380                 


Asp Gly Trp Tyr Arg Thr Gly Asp Leu Ala Arg Arg Ser Glu Thr Gly 
385                 390                 395                 400 


His Val Thr Ile Thr Gly Arg Ile Lys Glu Leu Ile Ile Arg Ser Gly 
                405                 410                 415     


Glu Asn Ile His Pro His Glu Ile Glu Ala Val Ala Leu Asp Val Pro 
            420                 425                 430         


Gly Val Lys Asp Ala Ala Ala Ala Gly Lys Arg His Pro Val Leu Gly 
        435                 440                 445             


Glu Val Pro Val Leu Tyr Val Val Pro Glu Thr Gly Gly Val Asp Ala 
    450                 455                 460                 


Asp Met Val Leu Ala Val Cys Arg Glu Arg Leu Ser Tyr Phe Lys Val 
465                 470                 475                 480 


Pro Glu Glu Ile Tyr Arg Val Asp Ala Ile Pro Arg Thr Ala Ser Gly 
                485                 490                 495     


Lys Val Lys Arg Ser Ser Leu Thr Glu Glu Pro Ala Glu Leu Leu Ala 
            500                 505                 510         


Gly Ala Ser Gly Gly Glu Thr Leu His Arg Leu Glu Trp Ile Pro Leu 
        515                 520                 525             


Glu Leu Pro Glu Gln Ala Ala Pro Asp Gly His Val Val Val Arg Val 
    530                 535                 540                 


Asp Ser Leu Ala Ser Asp Asp Ser Asp Leu Ala Asp Ala Asp Leu Ala 
545                 550                 555                 560 


Asp Ala Val Arg Asp Leu Ala Arg Ser Trp Leu Ala Asp Lys Arg Arg 
                565                 570                 575     


Ala Asp Ser Thr Leu Val Phe Val Thr Arg Arg Ala Val His Thr Gly 
            580                 585                 590         


Pro Ser Asp Ile Pro Ser Pro Glu His Ala Ala Val Trp Asp Ala Ile 
        595                 600                 605             


Arg Arg Glu Gln Thr Glu Asn Pro Gly Val Phe Val Val Ile Asp Val 
    610                 615                 620                 


Asp Asp Asp Asp Asp Asp Asp Asp Asp Val Asn Asp Arg Glu Asp Asp 
625                 630                 635                 640 


Asp Thr Leu Leu Pro Ala Leu Ala Gly Leu Gly Glu Pro Gln Val Ala 
                645                 650                 655     


Leu Arg Asp Gly Asn Pro Leu Val Pro Arg Leu Ala His Ala Asn Thr 
            660                 665                 670         


Pro Asp Ser Gly Ser Leu Thr Ile Pro Glu Asp Arg Ala Trp Leu Leu 
        675                 680                 685             


Glu His Ser Arg Ser Gly Thr Leu Arg Asp Leu Ala Leu Val Pro Ala 
    690                 695                 700                 


Asp Ala Ala Glu Arg Pro Leu His Pro Gly Glu Val Arg Ile Ser Val 
705                 710                 715                 720 


Arg Ala Ala Gly Leu Asn Phe Arg Asp Val Leu Ile Ala Leu Gly Thr 
                725                 730                 735     


Tyr Pro Gly Glu Gly Leu Met Gly Gly Glu Ala Ala Gly Val Val Leu 
            740                 745                 750         


Glu Val Gly Ser Glu Val Ser Asp Leu Ala Pro Gly Asp Arg Val Phe 
        755                 760                 765             


Gly Leu Val Gly Ser Ala Phe Gly Thr Val Ala Ile Ala Asp Arg Arg 
    770                 775                 780                 


Leu Leu Gly Ala Ile Pro Asp Thr Trp Ser Phe Ala Thr Ala Ala Ser 
785                 790                 795                 800 


Ile Pro Ile Val Phe Ala Thr Ala Tyr Tyr Gly Leu Val Asp Leu Ala 
                805                 810                 815     


Gly Leu Ser Ala Gly Glu Ser Val Leu Ile His Ala Ala Ala Gly Gly 
            820                 825                 830         


Val Gly Met Ala Ala Thr Gln Ile Ala Arg His Leu Gly Ala Arg Ile 
        835                 840                 845             


Phe Ala Thr Ala Ser Val Gly Lys Gln His Ile Leu Ser Glu Ala Gly 
    850                 855                 860                 


Leu Glu Asp Thr Arg Ile Ala Gly Ser Arg Thr Leu Ala Phe Arg Glu 
865                 870                 875                 880 


Ala Phe Leu Asn Thr Thr Asp Gly Gln Gly Val Asp Val Val Leu Asn 
                885                 890                 895     


Ser Leu Ser Gly Asp Phe Val Asp Ala Ser Leu Asp Leu Leu Pro Arg 
            900                 905                 910         


Gly Gly Arg Phe Leu Glu Met Gly Lys Thr Asp Ile Arg Asp Ala Asp 
        915                 920                 925             


Arg Ile Thr Ala Asp Arg Pro Gly Thr Thr Tyr Gln Ala Phe Asp Leu 
    930                 935                 940                 


Leu Asp Ala Gly Pro Asp Arg Leu Arg Glu Ile Ile Ala Glu Leu Leu 
945                 950                 955                 960 


Pro Leu Phe Ala Gln Gly Val Leu Arg Pro Leu Pro Leu Leu Thr Trp 
                965                 970                 975     


Asp Ile Arg Lys Ala Arg Asp Ala Phe Ser Trp Met Ser Arg Ala Arg 
            980                 985                 990         


His Thr Gly Lys Ile Thr Phe Thr  Ile Pro Arg Gln Leu  Asp Pro Gly 
        995                 1000                 1005             


Gly Thr  Val Leu Ile Ala Asp  Gly Ser Gly Val Leu  Thr Gly Thr 
    1010                 1015                 1020             


Val Ala  Arg His Leu Val Ala  Glu Gln Gly Val Arg  His Leu Leu 
    1025                 1030                 1035             


Leu Leu  Ser Arg Ser Thr Pro  Asp Glu Ala Leu Ile  Asn Glu Leu 
    1040                 1045                 1050             


Ile Glu  Ser Gly Ala Arg Val  Asp Thr Ala Val Arg  Asp Val Ser 
    1055                 1060                 1065             


Asp Arg  Ala Gly Leu Glu Gln  Ala Leu Ala Gly Ile  Ser Pro Glu 
    1070                 1075                 1080             


His Pro  Leu Thr Ala Val Ile  His Thr Gly Gly Pro  Ala Val Ala 
    1085                 1090                 1095             


His Glu  Ser His Gln Leu His  Gly Leu Thr Lys Arg  Leu Asp Leu 
    1100                 1105                 1110             


Ala Ala  Phe Val Val Phe Ser  Gln Asp Ala Pro Ala  Ser Val Asp 
    1115                 1120                 1125             


Ala Leu  Ala Arg Arg Arg Arg  Ala Glu Gly Leu Pro  Thr Thr Thr 
    1130                 1135                 1140             


Ile Ala  Trp Gly Ile Pro Glu  Ala Glu Ala Val Val  Val Gln Gly 
    1145                 1150                 1155             


Pro Leu  Leu Gly Arg Ala Met  Ala Ser Ala Asp Ser  Ala His Ile 
    1160                 1165                 1170             


Val Thr  Arg Leu Asn Thr Val  Gly Leu Arg Ala Leu  Ala Ala Ala 
    1175                 1180                 1185             


Asp Thr  Leu Pro Pro Leu Leu  Arg Asn Leu Val Gly  Ala Gln Thr 
    1190                 1195                 1200             


Asp Asn  Thr Gln Gln Gln Ala  Trp Ser Arg Gln Leu  Leu Ala Ala 
    1205                 1210                 1215             


Glu Ala  Ala Arg Glu Gln Ala  Leu Arg Asp Leu Val  Arg Ser Cys 
    1220                 1225                 1230             


Val Met  Asp Ile Leu Gly Leu  Ser Ala Ala Asp Arg  Tyr Ala Pro 
    1235                 1240                 1245             


Asp Lys  Thr Phe Arg Glu Met  Gly Ile Asp Ser Leu  Thr Ala Val 
    1250                 1255                 1260             


Glu Leu  Arg Asn Ser Leu Ala  Lys Ala Thr Asp Leu  Arg Leu Pro 
    1265                 1270                 1275             


Ala Thr  Met Val Phe Asp Tyr  Pro Thr Pro Ala Met  Leu Val Val 
    1280                 1285                 1290             


Arg Leu  Gly Glu 
    1295         


<210>  162
<211>  1217
<212>  PRT
<213>  Streptomyces violaceusniger

<400>  162

Met Ser Arg Glu Glu Phe Ile Gln Pro Ile His Asp Leu Leu Arg Val 
1               5                   10                  15      


Asn Ala Glu Arg Leu Gly Asp Lys Ile Ala Tyr Ala Asp Ser Arg Arg 
            20                  25                  30          


Glu Leu Thr His Ala Glu Leu Arg Thr Arg Thr Gly Arg Ile Ala Gly 
        35                  40                  45              


His Leu Val Asp Leu Ala Val Glu Arg Gly Asp Arg Val Ala Ile Leu 
    50                  55                  60                  


Leu Gly Asn Arg Val Glu Thr Ile Glu Ser Tyr Leu Ala Ile Ala Arg 
65                  70                  75                  80  


Ala Gly Ala Ile Ala Val Pro Leu Asn Pro Asp Ala Thr Gly Ala Glu 
                85                  90                  95      


Val Ala His Phe Leu Ala Asp Ser Gly Ala Val Leu Val Ile Thr Asp 
            100                 105                 110         


Ser Ala His Leu Asp Asp Val Arg Arg Ala Ala Ala Ala Val Thr Val 
        115                 120                 125             


Val Leu Val Asp Glu Gly Pro Leu Pro Ala Gly Thr Arg Ser Phe Ala 
    130                 135                 140                 


Glu Leu Ala Thr Ala Glu Pro Pro Thr Pro Ala Arg Asp Asp Leu Gly 
145                 150                 155                 160 


Leu Asp Glu Ala Ala Trp Met Leu Tyr Thr Ser Gly Thr Thr Gly Thr 
                165                 170                 175     


Pro Lys Gly Val Val Ser Thr Gln Gly Ser Gly Leu Trp Ser Ala Ala 
            180                 185                 190         


Asn Cys Asp Val Pro Ala Trp Glu Leu Thr Glu Asn Asp Val Leu Leu 
        195                 200                 205             


Trp Pro Ala Pro Leu Phe His Ser Leu Ala His His Leu Cys Leu Leu 
    210                 215                 220                 


Ala Thr Thr Ala Val Gly Ala Thr Ala Arg Ile Met Ser Gly Phe Val 
225                 230                 235                 240 


Ala Gly Glu Val Leu His Glu Leu Glu Glu His Ala Cys Thr Val Leu 
                245                 250                 255     


Val Gly Val Pro Thr Met Tyr His Tyr Leu Leu Gly Ala Val Gly Glu 
            260                 265                 270         


Ala Gly Pro Arg Leu Pro Ser Leu Lys Met Gly Leu Val Ala Gly Ala 
        275                 280                 285             


Val Ser Pro Pro Ala Leu Ile Glu Gly Phe Glu Arg Val Phe Gly Val 
    290                 295                 300                 


Pro Leu Leu Asp Thr Tyr Gly Cys Thr Glu Thr Thr Gly Ser Leu Thr 
305                 310                 315                 320 


Val Asn Arg Leu Ser Gly Pro Arg Met Pro Gly Ser Cys Gly Gln Ala 
                325                 330                 335     


Val Pro Gly Ile Ser Leu Arg Phe Val Asp Pro His Thr Gly Ala Glu 
            340                 345                 350         


Val Ala Glu Gly Glu Glu Gly Glu Leu Trp Ala Ser Gly Pro Ser Leu 
        355                 360                 365             


Met Ile Gly Tyr His Gly Arg Pro Asp Ala Thr Arg Glu Val Leu Ser 
    370                 375                 380                 


Asp Gly Trp Tyr Arg Thr Gly Asp Leu Ala Arg Arg Ser Glu Thr Gly 
385                 390                 395                 400 


His Val Thr Ile Thr Gly Arg Val Lys Glu Leu Ile Ile Arg Gly Gly 
                405                 410                 415     


Glu Asn Ile His Pro Arg Asp Ile Glu Ala Val Ala Leu Glu Leu Pro 
            420                 425                 430         


Gly Val Arg Asp Ala Ala Ala Ala Gly Lys Gln His Pro Val Leu Gly 
        435                 440                 445             


Glu Ile Pro Ala Leu Tyr Leu Val Pro Asp Ala Asp Gly Val Asp Ala 
    450                 455                 460                 


Glu Ala Val Leu Ala Ala Cys Arg Glu Lys Leu Ser Tyr Phe Lys Val 
465                 470                 475                 480 


Pro Glu Glu Ile Tyr Arg Val Asp Ala Ile Pro Arg Thr Leu Ser Gly 
                485                 490                 495     


Lys Val Lys Arg Ala Ala Leu Thr Glu Ala Pro Ala Glu Leu Leu Ser 
            500                 505                 510         


Ala Ala Ser Gly Asn Gly Ser Leu Tyr Arg Leu Glu Trp Val Pro Ala 
        515                 520                 525             


Glu Thr Pro Pro Ala Gly Thr Gly Gly Pro Val Ala Val His Val Thr 
    530                 535                 540                 


Arg Arg Ala Val Ala Thr Gly Pro Ala Asp Leu Pro Asp Gln Glu Gln 
545                 550                 555                 560 


Ala Ala Thr Trp Asp Ala Leu Arg Gly Glu Gln Thr Gly Pro Gly Gly 
                565                 570                 575     


Pro Val Leu Ile Asp Leu Asp Gly Ala Asp Ile Asp Asp Ala Arg Leu 
            580                 585                 590         


Ser Ala Leu Ala Ser Leu Gly Glu Pro Gln Ile Val Val Arg Asp Asp 
        595                 600                 605             


Thr Pro Leu Val Ala Arg Leu Ala Arg Glu Lys Ser Pro Ala Leu Thr 
    610                 615                 620                 


Ile Pro Gly Glu Arg Ala Trp Val Leu Glu Pro Asp His Ser Gly Val 
625                 630                 635                 640 


Leu Gln Glu Leu Ala Leu Val Ala Ala Asp Thr Asp Val Arg Pro Leu 
                645                 650                 655     


Arg Pro Gly Glu Val Arg Ile Glu Val Arg Ala Ala Gly Leu Asn Phe 
            660                 665                 670         


Arg Asp Val Leu Val Ala Leu Gly Thr Asp Leu Gly Asp Gly Val Phe 
        675                 680                 685             


Gly Ala Glu Gly Ala Gly Val Val Leu Glu Thr Gly Ser Asp Val Arg 
    690                 695                 700                 


Asp Leu Arg Pro Gly Asp Arg Val Phe Gly Leu Leu Glu Gly Gly His 
705                 710                 715                 720 


Gly Ser Ile Ala Ile Ala Asp Arg Arg Met Leu Ala Val Ile Pro Glu 
                725                 730                 735     


Gly Trp Ser Phe Ala Thr Ala Ala Ser Val Pro Glu Val Phe Val Ile 
            740                 745                 750         


Ala Tyr Tyr Gly Leu Val Asp Leu Ala Gly Leu Arg Ala Gly Glu Ser 
        755                 760                 765             


Val Leu Ile His Ala Ala Thr Gly Gly Val Gly Met Ala Ala Thr Gln 
    770                 775                 780                 


Ile Ala Arg His Leu Gly Ala Gln Val Tyr Ala Thr Ala Gly Val Gly 
785                 790                 795                 800 


Lys Gln His Ile Leu Arg Asp Ala Gly Leu Gly Asp Asp Arg Ile Ala 
                805                 810                 815     


Asp Ser Arg Thr Thr Asp Phe Arg Glu Ala Phe Arg Asp Ser Thr Gln 
            820                 825                 830         


Gly Arg Gly Val Asp Val Val Leu Asn Ser Leu Lys Gly Asp Phe Val 
        835                 840                 845             


Asp Ala Ser Leu Asp Leu Leu Ala Asp Gly Gly Arg Phe Leu Glu Leu 
    850                 855                 860                 


Gly Gln Thr Asp Ile Arg Asp Ala Gly Glu Ile Ala Ala Glu Arg Pro 
865                 870                 875                 880 


Gly Thr Thr Tyr His Ser Phe Thr Arg Met Asn Ala Gly Pro Asp Arg 
                885                 890                 895     


Leu Arg Glu Ile Ile Ala Glu Leu Leu Ala Leu Phe Glu Gln Gly Val 
            900                 905                 910         


Leu Arg Pro Ser Pro Val His Thr Trp Asp Ile Arg His Ala Arg Glu 
        915                 920                 925             


Ala Phe Ser Trp Met Ser Gly Gly Arg His Thr Gly Lys Met Val Leu 
    930                 935                 940                 


Thr Met Pro Gln Arg Ile Asp Pro Gly Gly Thr Val Leu Ile Ala Gly 
945                 950                 955                 960 


Asp Ser Glu Ala Leu Ala Arg Ile Ala Ala Arg His Leu Gly Val Arg 
                965                 970                 975     


His Leu Leu Leu Asp Arg Gly Val Ala Asp Ala Ala Pro Asp Ala Val 
            980                 985                 990         


Val Cys Asp Val Ser Asp His Asp  Ala Leu Glu Arg Val  Leu Ala Asp 
        995                 1000                 1005             


Leu Ser  Pro Glu His Pro Leu  Thr Ala Val Ile His  Thr Gly Gly 
    1010                 1015                 1020             


Ala Ala  Val Thr Asp Glu Ile  Arg Arg Leu His Asp  Leu Thr Glu 
    1025                 1030                 1035             


Ser Leu  Asp Leu Thr Asp Phe  Val Val Phe Ser Gln  Asp Ala Pro 
    1040                 1045                 1050             


Ala Ala  Val Glu Ala Phe Ala  Arg Ser Arg Arg Ala  His Gly Leu 
    1055                 1060                 1065             


Pro Val  Arg Thr Ile Ala Trp  Gly Ile Pro Glu Ala  Asp Pro Val 
    1070                 1075                 1080             


Val Ala  Asp Glu His Leu Leu  Gly Arg Ala Leu Ala  Ser Ala Glu 
    1085                 1090                 1095             


Gln Ala  Gln Ile Val Ala Arg  Val Asn Thr Ala Gly  Leu Arg Ala 
    1100                 1105                 1110             


Leu Thr  Ala Ala Asn Ala Leu  Pro Thr Leu Leu Arg  Asn Leu Ile 
    1115                 1120                 1125             


Arg Ala  Glu Pro Glu Glu Thr  Gly Gln Ser Ala Trp  Pro His Arg 
    1130                 1135                 1140             


Phe Glu  Ala Ala Gly Ala Asp  Arg Glu Glu Ala Leu  Leu Asp Leu 
    1145                 1150                 1155             


Ile Arg  Ala Asn Val Val Asp  Ile Leu Ser Leu Pro  Thr Ala Asp 
    1160                 1165                 1170             


Arg Tyr  Ala Pro Asp Arg Thr  Phe Arg Glu Met Gly  Ile Asp Ser 
    1175                 1180                 1185             


Leu Thr  Ala Val Gly Leu Arg  Asn Ser Leu Ala Lys  Ala Thr Gly 
    1190                 1195                 1200             


Leu Pro  Leu Pro Thr Thr Met  Val Phe Asp Tyr Pro  Thr Pro 
    1205                 1210                 1215         


<210>  163
<211>  1299
<212>  PRT
<213>  Streptomyces filamentosus

<400>  163

Met Ser His Ala Lys Leu Ile Gln Pro Ile Tyr Asp Leu Leu Arg Val 
1               5                   10                  15      


Asn Ala Glu Arg Leu Gly Asp Lys Ile Ala Tyr Ala Asp Ser Arg His 
            20                  25                  30          


Ala Leu Thr Tyr Thr Glu Leu Glu Ala Arg Thr Gly Arg Leu Ala Gly 
        35                  40                  45              


His Leu Ala Asp Leu Gly Val Glu Arg Gly Asp Arg Val Ala Ile Leu 
    50                  55                  60                  


Leu Asp Asn Arg Val Glu Thr Ile Glu Ser Tyr Leu Ala Ile Ala Arg 
65                  70                  75                  80  


Ala Ser Ala Ile Ala Val Pro Leu Asn Pro Ala Ala Ala Gly Asp Glu 
                85                  90                  95      


Leu Ala His Phe Leu Ser Asp Ser Gly Ser Val Leu Val Ile Thr Asp 
            100                 105                 110         


Ser Ala His Leu Asp Asp Val Arg Leu Val Ala Pro Ala Val Thr Val 
        115                 120                 125             


Val Arg Val Asp Glu Asp Pro Val Pro Pro Gly Val Arg Ser Phe Ala 
    130                 135                 140                 


Glu Leu Val Ala Val Glu Pro Arg Thr Gln Ala Arg Asp Asp Leu Gly 
145                 150                 155                 160 


Leu Asp Glu Ala Ala Trp Met Leu Tyr Thr Ser Gly Thr Thr Gly Thr 
                165                 170                 175     


Pro Lys Gly Val Val Ser Thr Gln Gly Ser Gly Leu Trp Ser Ala Ala 
            180                 185                 190         


Phe Cys Asp Val Pro Ala Trp Glu Leu Thr Glu Glu Asp Val Leu Leu 
        195                 200                 205             


Trp Pro Ala Pro Leu Phe His Ser Leu Ala His His Leu Cys Leu Leu 
    210                 215                 220                 


Ala Thr Ile Thr Ala Gly Ala Thr Ala Arg Ile Met Asn Gly Phe Val 
225                 230                 235                 240 


Ala Ser Glu Val Leu Asn Glu Leu Glu Lys His Ala Cys Thr Val Leu 
                245                 250                 255     


Val Cys Val Pro Thr Met Tyr His Tyr Leu Leu Gly Ala Val Gly Glu 
            260                 265                 270         


Gly Glu Ser Arg Thr Phe Ser Leu Lys Leu Gly Val Val Ala Gly Ser 
        275                 280                 285             


Val Ser Pro Pro Ala Leu Ile Glu Gly Phe Glu Lys Ala Phe Gly Ala 
    290                 295                 300                 


Pro Leu Leu Asp Thr Tyr Gly Cys Thr Glu Thr Thr Gly Ser Leu Thr 
305                 310                 315                 320 


Val Asn Trp Leu Asn Gly Pro Arg Val Pro Gly Ser Cys Gly Thr Ala 
                325                 330                 335     


Val Pro Gly Val Thr Leu Arg Phe Val Asp Pro Ser Thr Gly Ala Asp 
            340                 345                 350         


Val Ala Asp Gly Glu Glu Gly Glu Leu Trp Ala Ser Ala Pro Ser Val 
        355                 360                 365             


Met Thr Gly Tyr His Gly Gln Pro Glu Ala Thr Arg Glu Val Leu Thr 
    370                 375                 380                 


Asp Gly Trp Tyr His Thr Gly Asp Leu Ala Arg Arg Ser Glu Thr Gly 
385                 390                 395                 400 


His Val Thr Ile Thr Gly Arg Ile Lys Glu Leu Ile Ile Arg Gly Gly 
                405                 410                 415     


Glu Asn Ile His Pro Gln Glu Ile Glu Ala Ala Val Leu Gly Leu Pro 
            420                 425                 430         


Gly Val Arg Asp Ala Ala Ala Ala Gly Arg Pro His Pro Val Leu Gly 
        435                 440                 445             


Asp Val Pro Ala Leu Tyr Ile Val Pro Asp Ala Asp Gly Val Asp Ala 
    450                 455                 460                 


Asp Ala Val Leu Ala Ala Cys Arg Glu Arg Leu Ser Tyr Phe Lys Val 
465                 470                 475                 480 


Pro Glu Glu Ile Tyr Arg Val Asp Ala Ile Pro Arg Thr Met Ser Gly 
                485                 490                 495     


Lys Val Lys Arg Thr Ser Leu Thr Glu Ala Pro Ala Glu Leu Leu Ala 
            500                 505                 510         


Gly Ala Ser Gly Ser Asp Ala Leu Tyr Arg Leu Lys Trp Val Pro Ala 
        515                 520                 525             


Glu Thr Pro Gly Pro Ala Ala Thr Gly Gly His Val Ile Val Arg Val 
    530                 535                 540                 


Ala Ser Leu Arg Ala Asp Gly Thr Glu Leu Ala Gly Ala Ala Arg Asp 
545                 550                 555                 560 


Leu Ala Arg Ser Trp Leu Ser Asp Glu Arg Arg Ala Gly Ala Thr Leu 
                565                 570                 575     


Val Phe Val Thr Gly Arg Ala Val Ser Ala Gly Pro Ser Asp Val Pro 
            580                 585                 590         


Val Pro Glu His Ala Ala Val Trp Asp Ala Ile Arg Asp Glu Gln Thr 
        595                 600                 605             


Glu Asn Pro Gly Ala Phe Val Leu Ile Asp Leu Glu Glu Ala Glu Thr 
    610                 615                 620                 


Glu Glu Pro Glu Ser Ala Ala Pro Glu Ala Gly Asp Pro Gln Ala Asp 
625                 630                 635                 640 


Thr Pro Gly Ala Asp Asp Thr Arg Leu Ser Thr Leu Val Ala Leu Gly 
                645                 650                 655     


Glu Pro Gln Ile Ala Leu Arg Asp Ser Thr Pro Leu Val Pro Arg Leu 
            660                 665                 670         


Ala Pro Glu Ser Ser Thr Ala Leu Thr Thr Pro Ala Ala Arg Ala Trp 
        675                 680                 685             


Val Leu Glu Pro Ala Arg Ser Gly Thr Leu Arg Glu Leu Ser Leu Val 
    690                 695                 700                 


Ala Ala Asp Thr Asp Ala Arg Pro Leu Arg Pro Gly Glu Val Arg Val 
705                 710                 715                 720 


Asp Val Arg Ala Ala Gly Leu Asn Phe Arg Asp Val Leu Ile Ala Leu 
                725                 730                 735     


Gly Thr Tyr Pro Gly Asp Gly Val Met Gly Gly Glu Ala Ala Gly Val 
            740                 745                 750         


Val Leu Glu Val Gly Pro Glu Val Asn Asp Leu Ser Val Gly Asp Arg 
        755                 760                 765             


Val Phe Gly Leu Val Thr Asp Gly Phe Gly Pro Val Thr Ile Thr Asp 
    770                 775                 780                 


Arg Arg Leu Leu Ala Ala Met Pro Gln Asp Trp Ser Phe Thr Thr Ala 
785                 790                 795                 800 


Ala Ser Ala Ala Met Ala Phe Ala Thr Ala His Tyr Gly Leu Val Glu 
                805                 810                 815     


Leu Ala Gly Leu Lys Ala Gly Glu Ser Val Leu Ile His Ala Ala Thr 
            820                 825                 830         


Gly Gly Val Gly Met Ala Ala Thr Gln Ile Ala His His Leu Gly Ala 
        835                 840                 845             


His Ile Tyr Ala Thr Ala Ser Ser Gly Lys Gln His Leu Leu Arg Ala 
    850                 855                 860                 


Ala Gly Ile Asp Asp Asp Arg Ile Ala Asn Ser Arg Thr Thr Gly Phe 
865                 870                 875                 880 


Arg Asp Ala Phe Leu Asp Ser Thr Gly Gly Arg Gly Val Asp Val Val 
                885                 890                 895     


Leu Asn Ser Leu Ser Gly Glu Phe Val Asp Ser Ser Leu Asp Leu Leu 
            900                 905                 910         


Ala His Gly Gly Arg Phe Ile Glu Met Ser Thr Asp Ile Arg Asp Ala 
        915                 920                 925             


Gly Arg Ile Ala Ala Glu Arg Pro Gly Thr Thr Tyr Gln Ala Phe His 
    930                 935                 940                 


Leu Val Asp Ala Asp Pro Asp Arg Leu Arg Glu Ile Leu Thr Glu Leu 
945                 950                 955                 960 


Leu Ala Leu Phe Asp Gln Gly Ile Leu Asp Pro Leu Pro Val Gln Ala 
                965                 970                 975     


Trp Asp Ile Arg Gln Ala Arg Glu Ala Phe Ser Trp Met Ser Arg Ala 
            980                 985                 990         


Arg His Thr Gly Lys Leu Val Leu  Thr Ile Pro Gln His  Ile Asp Pro 
        995                 1000                 1005             


Asp Gly  Thr Val Leu Ile Thr  Gly Gly Ser Gly Gly  Leu Ala Gly 
    1010                 1015                 1020             


Val Val  Ala Arg His Leu Val  Ala Asp Lys Gly Ala  Arg Arg Leu 
    1025                 1030                 1035             


Leu Leu  Leu Ser Cys Asp Thr  Leu Asp Ala Thr Leu  Ala Ala Glu 
    1040                 1045                 1050             


Leu Thr  Glu Ser Gly Ala Arg  Val Asp Thr Ala Val  Cys Asp Val 
    1055                 1060                 1065             


Ser Asp  Arg Ala Ala Leu Ala  Gln Val Leu Ala Gly  Val Ser Pro 
    1070                 1075                 1080             


Glu His  Pro Leu Thr Ala Ile  Val His Ala Gly Gly  Ala Ala Val 
    1085                 1090                 1095             


Ala Asp  Glu Ser Arg Gln Leu  His His Leu Thr Lys  Asn Arg Asp 
    1100                 1105                 1110             


Leu Ala  Ala Phe Val Val Phe  Ser Gln Asp Ala Pro  Ala Ala Thr 
    1115                 1120                 1125             


Glu Ala  Phe Ala Gly Ile Arg  Gln Ala Glu Gly Leu  Pro Val Thr 
    1130                 1135                 1140             


Thr Ile  Ala Trp Gly Ile Pro  Glu Ala Glu Pro Val  Val Val Gly 
    1145                 1150                 1155             


Gln His  Leu Leu Asp Arg Ala  Met Ala Ser Ala Asp  Arg Ala His 
    1160                 1165                 1170             


Val Ala  Ala Arg Val Asn Thr  Ala Gly Leu Arg Ala  Leu Ala Ala 
    1175                 1180                 1185             


Ala Asn  Ala Leu Pro Pro Val  Leu Lys Asn Leu Val  Gly Ala Glu 
    1190                 1195                 1200             


Thr Asp  Gly Thr Gly His Gln  Asp Trp Ser Arg Arg  Phe Met Val 
    1205                 1210                 1215             


Ala Glu  Ala Ala Arg Gln Gln  Glu Leu Leu Asp Leu  Ile Arg Thr 
    1220                 1225                 1230             


Thr Val  Met Glu Ile Leu Ser  Leu Pro Thr Thr Ala  Arg Tyr Phe 
    1235                 1240                 1245             


Pro Asp  Arg Thr Phe Arg Glu  Asn Gly Ile Asp Ser  Leu Thr Ala 
    1250                 1255                 1260             


Val Glu  Leu Val Asn Ser Leu  Ala Lys Thr Thr Gly  Leu Arg Leu 
    1265                 1270                 1275             


Ser Ala  Thr Met Val Phe Asp  Tyr Pro Thr Pro Thr  Ala Leu Ala 
    1280                 1285                 1290             


Gly Arg  Met Arg Glu Leu 
    1295                 


<210>  164
<211>  1239
<212>  PRT
<213>  Streptomyces hygroscopicus

<400>  164

Met Ser Arg Leu Asp Leu Ile Arg Pro Leu Ser Glu Ser Leu Cys Ala 
1               5                   10                  15      


Ser Ala Ala Ser Phe Gly Asp Lys Val Ala Tyr Thr Asp Ser Arg Arg 
            20                  25                  30          


Ser Val Thr Tyr Ala Glu Leu Gln Ile Arg Thr Gly Arg Leu Ala Gly 
        35                  40                  45              


His Leu Ala Glu His Gly Val Ala Arg Gly Asp Arg Val Ala Ile Leu 
    50                  55                  60                  


Leu Gly Asn Arg Val Glu Ile Ile Glu Ser Tyr Leu Ala Val Ala Arg 
65                  70                  75                  80  


Ala Ser Ala Val Ala Val Pro Leu Asn Pro Asp Ala Met Asp Ala Glu 
                85                  90                  95      


Leu Ala His Phe Leu Arg Asp Ser Gly Ala Val Val Val Ile Thr Asp 
            100                 105                 110         


Leu Ala His Leu Glu Gln Thr Arg Gly Val Ala Pro Ala Met Thr Val 
        115                 120                 125             


Val Leu Ile Gly Asp Gly Arg Thr Val Pro Gly Thr Ser Ser Phe Ala 
    130                 135                 140                 


Glu Leu Ala Asp Thr Glu Pro Ala Ser Pro Ala Arg Asp Asp Leu Arg 
145                 150                 155                 160 


Leu Asp Glu Pro Ala Trp Met Leu Tyr Thr Ser Gly Thr Thr Gly Thr 
                165                 170                 175     


Pro Lys Gly Val Val Ser Ala Gln Arg Ser Gly Leu Trp Ser Ala Ala 
            180                 185                 190         


Ser Cys Asp Val Pro Ala Trp Asp Leu Ser Asp Glu Asp Leu Leu Leu 
        195                 200                 205             


Trp Pro Ala Pro Leu Phe His Ser Leu Gly His His Leu Cys Leu Leu 
    210                 215                 220                 


Ala Val Val Ala Val Gly Ala Ser Ala Arg Ile Met Ser Gly Phe Ala 
225                 230                 235                 240 


Ala Asp Glu Val Leu Asp Ala Leu Arg Glu His Pro Cys Thr Val Leu 
                245                 250                 255     


Val Gly Val Pro Thr Met Tyr Arg Tyr Leu Leu Ala Ala Val Gly Glu 
            260                 265                 270         


Ser Gly Ala Asp Ala Pro Ala Leu Lys Met Ala Leu Ile Ala Gly Ser 
        275                 280                 285             


Val Thr Pro Ala Ser Leu Val Glu Ala Phe Glu Arg Ser Phe Gly Val 
    290                 295                 300                 


Pro Leu Ile Asp Thr Tyr Gly Cys Thr Glu Thr Thr Gly Ser Val Thr 
305                 310                 315                 320 


Ala Asn Arg Leu His Gly Glu Arg Val Pro Gly Ser Cys Gly Val Pro 
                325                 330                 335     


Val Pro Gly Val Glu Ile Arg Leu Val Asp Pro Val Thr Gly Ala Asp 
            340                 345                 350         


Val Pro Leu Gly Ala Glu Gly Glu Leu Trp Ala Lys Thr Pro Ser Val 
        355                 360                 365             


Met Ile Gly Tyr His Gly Gln Pro Glu Ala Thr Gly Glu Val Leu Val 
    370                 375                 380                 


Asp Gly Trp Tyr Arg Ser Gly Asp Leu Ala Arg Arg Gln Glu Ser Gly 
385                 390                 395                 400 


His Ile Thr Ile Thr Gly Arg Val Lys Glu Leu Ile Ile Arg Ser Gly 
                405                 410                 415     


Glu Asn Ile His Pro Arg Glu Ile Glu Thr Val Ala Leu Glu Val Pro 
            420                 425                 430         


Gly Val Glu Asp Ala Ala Ala Ala Gly Lys Pro His Arg Val Leu Gly 
        435                 440                 445             


Glu Val Pro Val Leu Tyr Val Val Pro Ala Glu Ala Gly Val Asp Val 
    450                 455                 460                 


Thr Ala Val Phe Ala Ala Cys Arg Glu Gln Leu Ser Tyr Phe Lys Val 
465                 470                 475                 480 


Pro Glu Glu Ile Tyr Gln Val Glu Ser Ile Pro Arg Thr Pro Ser Gly 
                485                 490                 495     


Lys Val Lys Arg Gly Leu Leu Thr Glu Gln Pro Ala Glu Leu Leu Ala 
            500                 505                 510         


Ala Ala Asp Gly Gly Gly Ser Leu Tyr Arg Val Glu Trp Arg Pro Ala 
        515                 520                 525             


Val Pro Pro Gly Ala Gly Asp Thr Gly Gly Asp Ser Pro Val Val Val 
    530                 535                 540                 


Arg Val Asp Ser Leu Pro Ala Asp Glu Gln Glu Leu Leu Gly Ala Val 
545                 550                 555                 560 


Arg Asp Leu Ile His Asp Arg Ile Ala Asp Pro Arg Arg Thr Thr Ala 
                565                 570                 575     


Pro Leu Val Phe Val Thr Arg His Ala Val Leu Ser Arg Asn Pro Ala 
            580                 585                 590         


His Ala His Ala Ala Val Trp Asp Leu Val Ser Arg Ala Gln Ala Asp 
        595                 600                 605             


Asn Pro Gly Leu Phe Val Leu Val Asp Ala Asp Gly Asp Asp Ala Pro 
    610                 615                 620                 


Leu Pro Ser Ala Val Gly Leu Gly Glu Pro Arg Val Ala Trp Arg Asp 
625                 630                 635                 640 


Gly Gly Leu Leu Val Pro Arg Leu Ala His Pro Gly Thr Glu Ala Leu 
                645                 650                 655     


Ile Ala Pro Glu Ser Gly Ser Trp Leu Leu Ala Glu Thr Gly Gly Gly 
            660                 665                 670         


Thr Leu Arg Asp Leu Ala Leu Val Gly Thr Asp Thr Ala Asp Arg Val 
        675                 680                 685             


Leu Leu Pro Gly Glu Val Arg Ile Ala Val Arg Ala Ala Gly Leu Asn 
    690                 695                 700                 


Phe Arg Asp Val Thr Val Ala Leu Gly Val Val Ser Asp Asp Arg Leu 
705                 710                 715                 720 


Met Gly Gly Glu Ala Ala Gly Val Val Leu Asp Val Ala Pro Asp Val 
                725                 730                 735     


Thr Asp Leu Glu Pro Gly Asp Arg Val Phe Gly Leu Val Glu Gly Ala 
            740                 745                 750         


Phe Ala Ser Val Ala Val Thr Asp Arg Arg Leu Leu Gly Arg Ile Pro 
        755                 760                 765             


Ala Gly Trp Ser Phe Ala Thr Ala Ala Ser Val Pro Val Val Phe Ser 
    770                 775                 780                 


Thr Ala Tyr His Ala Leu Thr Asp Leu Val Asp Leu Arg Pro Gly Glu 
785                 790                 795                 800 


Ala Ile Leu Ile His Ala Ala Ala Gly Gly Val Gly Met Ala Ala Thr 
                805                 810                 815     


Gln Leu Ala Arg His Ile Gly Ala Lys Ile Tyr Ala Thr Ala Ser Pro 
            820                 825                 830         


Ala Lys Gln His Ala Leu Leu Gly Val Asp Gln Val Ala Asn Ser Arg 
        835                 840                 845             


Thr Thr Glu Phe Arg Gly Thr Phe Leu Glu Ala Thr Gly Gly Arg Gly 
    850                 855                 860                 


Val Asp Val Val Leu Asn Ser Leu Ala Gly Glu His Ile Asp Ala Ser 
865                 870                 875                 880 


Leu Glu Leu Leu Pro Arg Gly Gly Arg Phe Leu Glu Leu Gly Lys Thr 
                885                 890                 895     


Asp Leu Arg Asp Pro Arg His Leu Pro Ala Gly Val Ser Tyr Gln Val 
            900                 905                 910         


Leu Asn Arg Leu Asp Ser Ser Pro Asp Arg Val Arg Glu Ile Leu Ala 
        915                 920                 925             


Glu Leu Leu Val Met Phe Glu Arg Gly Val Leu Arg Pro Leu Pro Val 
    930                 935                 940                 


Arg Thr Trp Asp Ile Arg Glu Ala Pro Glu Ala Phe Ser Trp Met Ser 
945                 950                 955                 960 


Arg Gly Arg His Leu Gly Lys Ile Val Leu Thr Ile Pro Arg Asp Leu 
                965                 970                 975     


Asp Pro Asp Gly Thr Val Leu Val Thr Gly Ala Ser Ala Asp His Met 
            980                 985                 990         


Ala Arg Tyr Leu Ser Ala Glu Arg  Gly His Ala His Val  Leu Val Ser 
        995                 1000                 1005             


Asp Asp  Pro Ala Ala Val Pro  Ala Thr His Pro Leu  Thr Ala Val 
    1010                 1015                 1020             


Val His  Thr Gly Gly Asp Glu  Val Val Ser Glu Ser  Thr Arg Leu 
    1025                 1030                 1035             


His Gln  Leu Thr Arg Glu Leu  Asp Leu Ala Ala Phe  Ala Val Phe 
    1040                 1045                 1050             


Ser Gln  Ser Ala Pro Ala Ser  Val Glu Ala Leu Val  Arg His Arg 
    1055                 1060                 1065             


Arg Thr  Glu Gly Leu Pro Ala  Thr Ala Val Ser Trp  Gly Leu Pro 
    1070                 1075                 1080             


Glu Ala  Glu Pro Ala Pro Val  Gln Gly Ala Leu Leu  Asp Arg Thr 
    1085                 1090                 1095             


Ile Ala  Ser Val Glu Pro Ala  His Val Val Thr Arg  Val Asn Ser 
    1100                 1105                 1110             


Ala Gly  Leu Arg Ala Leu Ala  Asn Ser Gly Glu Leu  Pro Ser Val 
    1115                 1120                 1125             


Leu Arg  Asp Val Thr Pro Ala  Leu Ser Ala Lys Trp  Pro Arg Pro 
    1130                 1135                 1140             


Gly Thr  Pro Arg Pro Gly Thr  Pro Arg Pro Gly Thr  Pro His Pro 
    1145                 1150                 1155             


Ala Ala  Leu Asp Gln Ala Ala  Leu Leu Asp Leu Val  Arg Glu Ser 
    1160                 1165                 1170             


Leu Thr  Thr Val Leu Gly Leu  Pro Gly Val Glu Ser  Cys Ala Pro 
    1175                 1180                 1185             


Asp Arg  Pro Phe Arg Glu Thr  Gly Leu Asp Ser Leu  Thr Thr Ile 
    1190                 1195                 1200             


Gly Leu  Ala Asn Thr Leu Ser  Ala Arg Leu Gly Arg  Lys Leu Pro 
    1205                 1210                 1215             


Ala Thr  Met Ile Phe Asp His  Pro Thr Pro Arg Thr  Leu Ala Thr 
    1220                 1225                 1230             


Arg Leu  Ala Glu Glu Leu 
    1235                 


<210>  165
<211>  878
<212>  PRT
<213>  Micromonospora sp.

<400>  165

Met Thr Pro Ala Tyr Asp Val Arg Pro Leu Pro Glu Leu Leu Ile Ala 
1               5                   10                  15      


Asn Ala Glu Arg Leu Gly Asp Lys Pro Ala Tyr Thr Gly Leu His Arg 
            20                  25                  30          


Thr Val Gly His Ala Glu Leu Ala Asp Arg Thr Arg Arg Ala Ala Gly 
        35                  40                  45              


His Leu Ala Gly Phe Ala Ala Arg Gly Asp Arg Ile Ala Leu Leu Leu 
    50                  55                  60                  


Gly Asn Arg Val Glu Met Val Glu Gly Tyr Leu Ala Val Ala Arg Ala 
65                  70                  75                  80  


Ala Ala Val Ala Val Pro Leu Asn Pro Gln Ala Ser Asp Ala Glu Leu 
                85                  90                  95      


Ala His Phe Leu Thr Asp Ser Glu Ala Val Ala Val Leu Ala Asp Ala 
            100                 105                 110         


Glu His Thr Glu Gln Val Arg Arg Val Ala Pro Gly Leu Arg Leu Val 
        115                 120                 125             


Pro Ile Gly Glu Trp Glu Thr Leu Ala Thr Thr Glu Pro Asp Arg Pro 
    130                 135                 140                 


Ala Arg Asp Asp Leu Gly Leu Asp Glu Val Ala Trp Met Leu Tyr Thr 
145                 150                 155                 160 


Ser Gly Thr Thr Gly Ala Pro Lys Gly Val Leu Ser Thr Gln Gly Ser 
                165                 170                 175     


Gly Leu Trp Ser Ala Tyr His Cys Asp Val Pro Ala Leu Gly Leu Thr 
            180                 185                 190         


Asp Ala Asp Val Leu Leu Trp Pro Ala Pro Leu Phe His Ser Leu Ala 
        195                 200                 205             


His His Leu Ala Val Leu Ala Ala Thr Val Ser Gly Ala Thr Val Arg 
    210                 215                 220                 


Leu Leu Ser Gly Phe Ala Ala Asp Glu Val Leu Arg Glu Leu Arg Glu 
225                 230                 235                 240 


Glu Gly Cys Thr Leu Leu Ala Gly Val Pro Thr Met Tyr His Tyr Leu 
                245                 250                 255     


Leu Gly Ala Ala Gly Pro Asp Asp Glu Val Arg Ala Pro Ala Leu Arg 
            260                 265                 270         


Gly Ala Val Val Ala Gly Ala Val Thr Pro Ala Ala Leu Ile Thr Ala 
        275                 280                 285             


Phe Gly Glu Arg Phe Gly Ala Pro Leu Leu Asp Thr Tyr Gly Cys Thr 
    290                 295                 300                 


Glu Thr Thr Gly Ser Leu Thr Ile Asn Arg Leu Asp Gly Pro Arg Val 
305                 310                 315                 320 


Pro Gly Ser Cys Gly Val Ala Val Pro Gly Val Arg Leu Arg Leu Val 
                325                 330                 335     


Asp Pro Arg Thr Gly Asp Asp Ala Pro Glu Gly Gly Glu Gly Glu Ile 
            340                 345                 350         


Trp Ala Ser Gly Pro Ser Leu Met Arg Gly Tyr His Arg Arg Pro Asp 
        355                 360                 365             


Ala Thr Ala Glu Val Leu Ala Asp Gly Trp Tyr Arg Thr Gly Asp Leu 
    370                 375                 380                 


Ala Val Arg Ala Ala Thr Gly His Ile Thr Ile Thr Gly Arg Val Lys 
385                 390                 395                 400 


Glu Leu Ile Ile Arg Gly Gly Glu Asn Ile His Pro Arg Glu Ile Glu 
                405                 410                 415     


Ala Val Leu Ala Glu Val Pro Gly Val Ala Asp Val Ala Val Ala Gly 
            420                 425                 430         


Arg Ser His Ala Val Leu Gly Asp Leu Pro Val Ala Tyr Leu Val Thr 
        435                 440                 445             


Glu Ala Gly Leu Asp Pro Ala Ala Leu Phe Ala Ala Cys Arg Glu Arg 
    450                 455                 460                 


Leu Ser Ser Phe Lys Val Pro Glu Glu Val Tyr Arg Val Ala Ala Val 
465                 470                 475                 480 


Pro Arg Thr Pro Ser Gly Lys Ile Lys Arg Arg Glu Leu Val Ala Gly 
                485                 490                 495     


Pro Ala Glu Leu Leu Ala Thr Ala Gly Gly Ala Glu Thr Leu Leu Arg 
            500                 505                 510         


Thr Arg Trp Thr Ala Val Asp Val Leu Asp Pro Ala Ser Leu Asp Gly 
        515                 520                 525             


Trp Arg Val Val His Ala Asp Gln Glu Val Asp Leu Gly Gly Arg Leu 
    530                 535                 540                 


Asp Asp Asp Gly Pro Ala Ile Val Val Thr Thr Arg Ala Val Arg Thr 
545                 550                 555                 560 


Ser Ala Asp Glu Arg Pro Ser Ala Ser Ala Ala Ala Ala Trp Asp Leu 
                565                 570                 575     


Val Thr Ala Ala Gln Ala Arg Arg Pro Gly Arg Tyr Leu Leu Val Asp 
            580                 585                 590         


Thr Asp Gly Val Pro Gly Gly Leu Gly Ala Ala Leu Ala Thr Gly Glu 
        595                 600                 605             


Pro Gln Val Ala Val Arg Glu Asp Val Val Leu Val Pro Arg Leu Glu 
    610                 615                 620                 


Ala Ala Gly Glu Thr Gly Ala Pro Val Arg Leu Asp Gly Thr Val Leu 
625                 630                 635                 640 


Val Thr Gly Glu His Thr Glu Arg Val Ala Arg His Leu Arg Ala Arg 
                645                 650                 655     


Gly Val Thr Val Thr Asp Asp Pro Ala Ala Arg Pro Leu His Ala Val 
            660                 665                 670         


Val His Val Gly Gly Thr Ser Gly Leu Ala Glu Leu Ala Glu Leu Thr 
        675                 680                 685             


Gly Cys Pro Glu Arg Ala Ala Phe Val Val Cys Thr Glu Asp Ser Arg 
    690                 695                 700                 


Ala Thr Ala Asp Ala Leu Val Arg Ala Ile Pro Gly Gly Val Ala Val 
705                 710                 715                 720 


Gly Val Gly Leu Pro Gly Ile Glu Pro Ala Ala Leu Leu Pro Glu Leu 
                725                 730                 735     


Leu Asp Arg Leu Thr Ala Asp Gly Pro Tyr Val Val Ala Arg Pro Gly 
            740                 745                 750         


Ser Thr Gly Leu Arg Ala Leu Ala Thr Ala Gly Arg Leu Pro Ala Gly 
        755                 760                 765             


Leu Gly Ala Leu Val Asp Thr Gly Ala Ala Pro Asp Pro Asp Ala Ala 
    770                 775                 780                 


Val Arg Arg Asp Leu Val Arg Arg Leu Ile Ala Leu Pro Arg Arg Ala 
785                 790                 795                 800 


Arg Asp Gln Ala Leu Val Glu Leu Val Trp Asp Ala Val Arg Ala Thr 
                805                 810                 815     


Leu Gly Ala Gly Ala Thr Pro Gly Gly Pro Gly Gln Ala Phe Ser Glu 
            820                 825                 830         


Val Gly Phe Asp Ser Leu Thr Ser Val Gln Leu Arg Asn Arg Leu Val 
        835                 840                 845             


Ala Ala Thr Gly Val Arg Leu Ser Ala Thr Ala Val Phe Asp Phe Pro 
    850                 855                 860                 


Thr Pro Arg Ala Leu Ala Asp Glu Leu Gly Arg Val Leu Ile 
865                 870                 875             


<210>  166
<211>  7934
<212>  PRT
<213>  Streptomyces violaceusniger

<400>  166

Met Ser Arg Glu Glu Phe Ile Gln Pro Ile His Asp Leu Leu Arg Val 
1               5                   10                  15      


Asn Ala Glu Arg Leu Gly Asp Lys Ile Ala Tyr Ala Asp Ser Arg Arg 
            20                  25                  30          


Glu Leu Thr His Ala Glu Leu Arg Thr Arg Thr Gly Arg Ile Ala Gly 
        35                  40                  45              


His Leu Val Asp Leu Ala Val Glu Arg Gly Asp Arg Val Ala Ile Leu 
    50                  55                  60                  


Leu Gly Asn Arg Val Glu Thr Ile Glu Ser Tyr Leu Ala Ile Ala Arg 
65                  70                  75                  80  


Ala Gly Ala Ile Ala Val Pro Leu Asn Pro Asp Ala Thr Gly Ala Glu 
                85                  90                  95      


Val Ala His Phe Leu Ala Asp Ser Gly Ala Val Leu Val Ile Thr Asp 
            100                 105                 110         


Ser Ala His Leu Asp Asp Val Arg Arg Ala Ala Ala Ala Val Thr Val 
        115                 120                 125             


Val Leu Val Asp Glu Gly Pro Leu Pro Ala Gly Thr Arg Ser Phe Ala 
    130                 135                 140                 


Glu Leu Ala Thr Ala Glu Pro Pro Thr Pro Ala Arg Asp Asp Leu Gly 
145                 150                 155                 160 


Leu Asp Glu Ala Ala Trp Met Leu Tyr Thr Ser Gly Thr Thr Gly Thr 
                165                 170                 175     


Pro Lys Gly Val Val Ser Thr Gln Gly Ser Gly Leu Trp Ser Ala Ala 
            180                 185                 190         


Asn Cys Asp Val Pro Ala Trp Glu Leu Thr Glu Asn Asp Val Leu Leu 
        195                 200                 205             


Trp Pro Ala Pro Leu Phe His Ser Leu Ala His His Leu Cys Leu Leu 
    210                 215                 220                 


Ala Thr Thr Ala Val Gly Ala Thr Ala Arg Ile Met Ser Gly Phe Val 
225                 230                 235                 240 


Ala Gly Glu Val Leu His Glu Leu Glu Glu His Ala Cys Thr Val Leu 
                245                 250                 255     


Val Gly Val Pro Thr Met Tyr His Tyr Leu Leu Gly Ala Val Gly Glu 
            260                 265                 270         


Ala Gly Pro Arg Leu Pro Ser Leu Lys Met Gly Leu Val Ala Gly Ala 
        275                 280                 285             


Val Ser Pro Pro Ala Leu Ile Glu Gly Phe Glu Arg Val Phe Gly Val 
    290                 295                 300                 


Pro Leu Leu Asp Thr Tyr Gly Cys Thr Glu Thr Thr Gly Ser Leu Thr 
305                 310                 315                 320 


Val Asn Arg Leu Ser Gly Pro Arg Met Pro Gly Ser Cys Gly Gln Ala 
                325                 330                 335     


Val Pro Gly Ile Ser Leu Arg Phe Val Asp Pro His Thr Gly Ala Glu 
            340                 345                 350         


Val Ala Glu Gly Glu Glu Gly Glu Leu Trp Ala Ser Gly Pro Ser Leu 
        355                 360                 365             


Met Ile Gly Tyr His Gly Arg Pro Asp Ala Thr Arg Glu Val Leu Ser 
    370                 375                 380                 


Asp Gly Trp Tyr Arg Thr Gly Asp Leu Ala Arg Arg Ser Glu Thr Gly 
385                 390                 395                 400 


His Val Thr Ile Thr Gly Arg Val Lys Glu Leu Ile Ile Arg Gly Gly 
                405                 410                 415     


Glu Asn Ile His Pro Arg Asp Ile Glu Ala Val Ala Leu Glu Leu Pro 
            420                 425                 430         


Gly Val Arg Asp Ala Ala Ala Ala Gly Lys Gln His Pro Val Leu Gly 
        435                 440                 445             


Glu Ile Pro Ala Leu Tyr Leu Val Pro Asp Ala Asp Gly Val Asp Ala 
    450                 455                 460                 


Glu Ala Val Leu Ala Ala Cys Arg Glu Lys Leu Ser Tyr Phe Lys Val 
465                 470                 475                 480 


Pro Glu Glu Ile Tyr Arg Val Asp Ala Ile Pro Arg Thr Leu Ser Gly 
                485                 490                 495     


Lys Val Lys Arg Ala Ala Leu Thr Glu Ala Pro Ala Glu Leu Leu Ser 
            500                 505                 510         


Ala Ala Ser Gly Asn Gly Ser Leu Tyr Arg Leu Glu Trp Val Pro Ala 
        515                 520                 525             


Glu Thr Pro Pro Ala Gly Thr Gly Gly Pro Val Ala Val His Val Thr 
    530                 535                 540                 


Arg Arg Ala Val Ala Thr Gly Pro Ala Asp Leu Pro Asp Gln Glu Gln 
545                 550                 555                 560 


Ala Ala Thr Trp Asp Ala Leu Arg Gly Glu Gln Thr Gly Pro Gly Gly 
                565                 570                 575     


Pro Val Leu Ile Asp Leu Asp Gly Ala Asp Ile Asp Asp Ala Arg Leu 
            580                 585                 590         


Ser Ala Leu Ala Ser Leu Gly Glu Pro Gln Ile Val Val Arg Asp Asp 
        595                 600                 605             


Thr Pro Leu Val Ala Arg Leu Ala Arg Glu Lys Ser Pro Ala Leu Thr 
    610                 615                 620                 


Ile Pro Gly Glu Arg Ala Trp Val Leu Glu Pro Asp His Ser Gly Val 
625                 630                 635                 640 


Leu Gln Glu Leu Ala Leu Val Ala Ala Asp Thr Asp Val Arg Pro Leu 
                645                 650                 655     


Arg Pro Gly Glu Val Arg Ile Glu Val Arg Ala Ala Gly Leu Asn Phe 
            660                 665                 670         


Arg Asp Val Leu Val Ala Leu Gly Thr Asp Leu Gly Asp Gly Val Phe 
        675                 680                 685             


Gly Ala Glu Gly Ala Gly Val Val Leu Glu Thr Gly Ser Asp Val Arg 
    690                 695                 700                 


Asp Leu Arg Pro Gly Asp Arg Val Phe Gly Leu Leu Glu Gly Gly His 
705                 710                 715                 720 


Gly Ser Ile Ala Ile Ala Asp Arg Arg Met Leu Ala Val Ile Pro Glu 
                725                 730                 735     


Gly Trp Ser Phe Ala Thr Ala Ala Ser Val Pro Glu Val Phe Val Ile 
            740                 745                 750         


Ala Tyr Tyr Gly Leu Val Asp Leu Ala Gly Leu Arg Ala Gly Glu Ser 
        755                 760                 765             


Val Leu Ile His Ala Ala Thr Gly Gly Val Gly Met Ala Ala Thr Gln 
    770                 775                 780                 


Ile Ala Arg His Leu Gly Ala Gln Val Tyr Ala Thr Ala Gly Val Gly 
785                 790                 795                 800 


Lys Gln His Ile Leu Arg Asp Ala Gly Leu Gly Asp Asp Arg Ile Ala 
                805                 810                 815     


Asp Ser Arg Thr Thr Asp Phe Arg Glu Ala Phe Arg Asp Ser Thr Gln 
            820                 825                 830         


Gly Arg Gly Val Asp Val Val Leu Asn Ser Leu Lys Gly Asp Phe Val 
        835                 840                 845             


Asp Ala Ser Leu Asp Leu Leu Ala Asp Gly Gly Arg Phe Leu Glu Leu 
    850                 855                 860                 


Gly Gln Thr Asp Ile Arg Asp Ala Gly Glu Ile Ala Ala Glu Arg Pro 
865                 870                 875                 880 


Gly Thr Thr Tyr His Ser Phe Thr Arg Met Asn Ala Gly Pro Asp Arg 
                885                 890                 895     


Leu Arg Glu Ile Ile Ala Glu Leu Leu Ala Leu Phe Glu Gln Gly Val 
            900                 905                 910         


Leu Arg Pro Ser Pro Val His Thr Trp Asp Ile Arg His Ala Arg Glu 
        915                 920                 925             


Ala Phe Ser Trp Met Ser Gly Gly Arg His Thr Gly Lys Met Val Leu 
    930                 935                 940                 


Thr Met Pro Gln Arg Ile Asp Pro Gly Gly Thr Val Leu Ile Ala Gly 
945                 950                 955                 960 


Asp Ser Glu Ala Leu Ala Arg Ile Ala Ala Arg His Leu Gly Val Arg 
                965                 970                 975     


His Leu Leu Leu Asp Arg Gly Val Ala Asp Ala Ala Pro Asp Ala Val 
            980                 985                 990         


Val Cys Asp Val Ser Asp His Asp  Ala Leu Glu Arg Val  Leu Ala Asp 
        995                 1000                 1005             


Leu Ser  Pro Glu His Pro Leu  Thr Ala Val Ile His  Thr Gly Gly 
    1010                 1015                 1020             


Ala Ala  Val Thr Asp Glu Ile  Arg Arg Leu His Asp  Leu Thr Glu 
    1025                 1030                 1035             


Ser Leu  Asp Leu Thr Asp Phe  Val Val Phe Ser Gln  Asp Ala Pro 
    1040                 1045                 1050             


Ala Ala  Val Glu Ala Phe Ala  Arg Ser Arg Arg Ala  His Gly Leu 
    1055                 1060                 1065             


Pro Val  Arg Thr Ile Ala Trp  Gly Ile Pro Glu Ala  Asp Pro Val 
    1070                 1075                 1080             


Val Ala  Asp Glu His Leu Leu  Gly Arg Ala Leu Ala  Ser Ala Glu 
    1085                 1090                 1095             


Gln Ala  Gln Ile Val Ala Arg  Val Asn Thr Ala Gly  Leu Arg Ala 
    1100                 1105                 1110             


Leu Thr  Ala Ala Asn Ala Leu  Pro Thr Leu Leu Arg  Asn Leu Ile 
    1115                 1120                 1125             


Arg Ala  Glu Pro Glu Glu Thr  Gly Gln Ser Ala Trp  Pro His Arg 
    1130                 1135                 1140             


Phe Glu  Ala Ala Gly Ala Asp  Arg Glu Glu Ala Leu  Leu Asp Leu 
    1145                 1150                 1155             


Ile Arg  Ala Asn Val Val Asp  Ile Leu Ser Leu Pro  Thr Ala Asp 
    1160                 1165                 1170             


Arg Tyr  Ala Pro Asp Arg Thr  Phe Arg Glu Met Gly  Ile Asp Ser 
    1175                 1180                 1185             


Leu Thr  Ala Val Gly Leu Arg  Asn Ser Leu Ala Lys  Ala Thr Gly 
    1190                 1195                 1200             


Leu Pro  Leu Pro Thr Thr Met  Val Phe Asp Tyr Pro  Thr Pro Ala 
    1205                 1210                 1215             


Val Leu  Thr Ala Arg Met Arg  Glu Leu Leu Ala Gly  Glu Ser Pro 
    1220                 1225                 1230             


Ala Pro  Ala Arg Thr Ala Ala  Arg Ala Val Ala Gln  Asp Glu Pro 
    1235                 1240                 1245             


Leu Ala  Ile Val Gly Met Ala  Cys Arg Leu Pro Gly  Gly Val Ser 
    1250                 1255                 1260             


Ser Pro  Asp Asp Leu Trp Arg  Leu Val Ala Ala Gly  Thr Asp Ala 
    1265                 1270                 1275             


Ile Ser  Glu Phe Pro Ala Asp  Arg Gly Trp Asp Val  Asp Asn Leu 
    1280                 1285                 1290             


Tyr Asp  Pro Asp Pro Asp Ala  Pro Gly Lys Thr Tyr  Thr Val Leu 
    1295                 1300                 1305             


Gly Gly  Phe Leu Asp Gly Val  Ala Gly Phe Asp Ala  Ser Phe Phe 
    1310                 1315                 1320             


Gly Ile  Ser Pro Arg Glu Ala  Leu Ala Met Asp Pro  Gln Gln Arg 
    1325                 1330                 1335             


Leu Met  Leu Glu Val Ser Trp  Glu Ala Phe Glu His  Ala Gly Ile 
    1340                 1345                 1350             


Pro Pro  Arg Ser Val Arg Gly  Ser Asp Ala Gly Val  Phe Met Gly 
    1355                 1360                 1365             


Ala Phe  Pro Ser Gly Tyr Asp  Ala Gly Leu Glu Glu  Phe Gly Met 
    1370                 1375                 1380             


Thr Gly  Asp Ala Val Ser Val  Leu Ser Gly Arg Val  Ser Tyr Phe 
    1385                 1390                 1395             


Phe Gly  Leu Glu Gly Pro Ala  Ile Thr Val Asp Thr  Ala Cys Ser 
    1400                 1405                 1410             


Ser Ser  Leu Val Ala Leu His  Gln Ala Ser Ser Ala  Leu Arg Gln 
    1415                 1420                 1425             


Gly Glu  Cys Ser Leu Ala Leu  Val Gly Gly Val Thr  Val Leu Ala 
    1430                 1435                 1440             


Thr Pro  Gln Thr Phe Val Glu  Phe Ser Arg Gln Arg  Gly Leu Ala 
    1445                 1450                 1455             


Leu Asp  Gly Arg Ser Lys Ala  Phe Ala Asp Ala Ala  Asp Gly Ala 
    1460                 1465                 1470             


Gly Trp  Ala Glu Gly Val Gly  Val Leu Val Val Glu  Arg Leu Ser 
    1475                 1480                 1485             


Asp Ala  Arg Ala Lys Gly His  Gln Ile Trp Gly Val  Ile Arg Gly 
    1490                 1495                 1500             


Ser Ala  Val Asn Gln Asp Gly  Ala Ser Asn Gly Leu  Ser Ala Pro 
    1505                 1510                 1515             


Asn Gly  Pro Ser Gln Gln Arg  Val Ile Arg Gln Ala  Leu Ala Asn 
    1520                 1525                 1530             


Ala Gly  Leu Ala Pro His Glu  Val Asp Val Val Glu  Ala His Gly 
    1535                 1540                 1545             


Thr Gly  Thr Thr Leu Gly Asp  Pro Ile Glu Ala Gln  Ala Val Ile 
    1550                 1555                 1560             


Ala Thr  Tyr Gly Gln Asp Arg  Glu Gln Pro Leu Leu  Leu Gly Ser 
    1565                 1570                 1575             


Leu Lys  Ser Asn Val Gly His  Thr Gln Ala Ala Ala  Gly Val Ser 
    1580                 1585                 1590             


Gly Val  Ile Lys Met Val Met  Ala Leu Gln His Asp  Thr Val Pro 
    1595                 1600                 1605             


Ala Thr  Leu His Val Asp Ala  Pro Ser Arg His Val  Asp Trp Thr 
    1610                 1615                 1620             


Ala Gly  Ala Val Glu Leu Val  Thr Glu Asn Arg Pro  Trp Pro Glu 
    1625                 1630                 1635             


Thr Gly  Arg Val Arg Arg Ala  Gly Val Ser Ser Phe  Gly Ile Ser 
    1640                 1645                 1650             


Gly Thr  Asn Ala His Val Ile  Leu Glu Ser Ala Pro  Glu Gln Pro 
    1655                 1660                 1665             


Val Ser  Pro Pro Glu Ala Val  Ala Pro Val Val Ala  Ser Asp Arg 
    1670                 1675                 1680             


Val Pro  Leu Val Ile Ser Ala  Lys Thr Pro Ala Ala  Leu Ala Glu 
    1685                 1690                 1695             


Met Glu  Asn Arg Leu Arg Ala  Tyr Leu Ala Ala Ala  Pro Gly Ala 
    1700                 1705                 1710             


Asp Pro  Arg Ala Val Ala Ser  Thr Leu Ala Thr Ala  Arg Ser Val 
    1715                 1720                 1725             


Phe Glu  His Arg Ala Val Leu  Leu Gly Glu Asn Thr  Ile Thr Gly 
    1730                 1735                 1740             


Thr Val  Ala Gly Ala Asp Pro  Arg Val Val Phe Val  Phe Pro Gly 
    1745                 1750                 1755             


Gln Gly  Trp Gln Gln Leu Gly  Met Gly Arg Ala Leu  Arg Glu Ser 
    1760                 1765                 1770             


Ser Pro  Val Phe Ala Ala Arg  Met Ala Glu Cys Ala  Ala Ala Leu 
    1775                 1780                 1785             


Ser Glu  Phe Val Asp Trp Asp  Leu Phe Thr Met Leu  Asp Asp Pro 
    1790                 1795                 1800             


Ala Val  Ile Asp Arg Ile Asp  Val Leu Gln Pro Ala  Cys Trp Ala 
    1805                 1810                 1815             


Val Met  Met Ser Leu Ala Ala  Val Trp Gln Ala Ala  Gly Val Arg 
    1820                 1825                 1830             


Pro Asp  Ala Val Ile Gly His  Ser Gln Gly Glu Ile  Ala Ala Ala 
    1835                 1840                 1845             


Cys Val  Ala Gly Ala Leu Ser  Leu Arg Asp Ala Ala  Arg Ile Val 
    1850                 1855                 1860             


Ala Leu  Arg Ser Gln Leu Leu  Ala Arg Glu Met Val  Gly His Gly 
    1865                 1870                 1875             


Val Met  Ala Ala Val Ala Leu  Pro Ala Asp Asp Ile  Pro Leu Val 
    1880                 1885                 1890             


Asp Gly  Val Trp Ile Gly Ala  Cys Asn Gly Pro Ser  Ser Thr Val 
    1895                 1900                 1905             


Ile Ser  Gly Thr Pro Glu Ala  Val Glu Val Val Val  Ala Ala Cys 
    1910                 1915                 1920             


Glu Glu  Arg Gly Ala Arg Val  Arg Arg Ile Thr Ala  Ala Val Ala 
    1925                 1930                 1935             


Ser His  Ser Pro Leu Gly Glu  Lys Ile Arg Thr Glu  Leu Leu Gly 
    1940                 1945                 1950             


Ile Ser  Ala Ser Ile Pro Ser  Arg Thr Pro Val Val  Pro Trp Leu 
    1955                 1960                 1965             


Ser Thr  Ala Asp Gly Ile Trp  Ile Glu Ala Pro Leu  Asp Pro Ala 
    1970                 1975                 1980             


Tyr Trp  Trp Arg Asn Leu Arg  Glu Pro Val Gly Phe  Gly Pro Ala 
    1985                 1990                 1995             


Val Asp  Leu Leu Gln Ala Arg  Gly Glu Asn Val Phe  Leu Glu Met 
    2000                 2005                 2010             


Ser Ala  Ser Pro Val Leu Leu  Pro Ala Met Asn Asp  Ala Val Thr 
    2015                 2020                 2025             


Val Ala  Thr Leu Arg Arg Asp  Asp Gly Thr Pro Asp  Arg Met Leu 
    2030                 2035                 2040             


Thr Ala  Leu Ala Glu Ala His  Ala His Gly Val Ile  Val Asp Trp 
    2045                 2050                 2055             


Pro Arg  Val Phe Gly Ser Thr  Thr Arg Val Leu Asp  Leu Pro Thr 
    2060                 2065                 2070             


Tyr Ala  Phe Glu His Gln Arg  Tyr Trp Ala Val Ser  Ala Asp Arg 
    2075                 2080                 2085             


Pro Ser  Asp Ala Gly His Pro  Met Val Glu Thr Val  Val Pro Leu 
    2090                 2095                 2100             


Pro Ala  Ser Gly Gly Val Ala  Leu Thr Gly Arg Val  Ser Leu Ala 
    2105                 2110                 2115             


Thr His  Ala Trp Leu Ala Asp  His Ala Val Arg Gly  Thr Ala Leu 
    2120                 2125                 2130             


Leu Pro  Gly Thr Ala Phe Val  Glu Leu Val Thr Arg  Ala Ala Thr 
    2135                 2140                 2145             


Glu Val  Asp Cys Pro Val Ile  Asp Glu Leu Val Ile  Glu Ala Pro 
    2150                 2155                 2160             


Leu Pro  Leu Thr Gln Thr Gly  Ala Val Gln Leu Ser  Thr Thr Val 
    2165                 2170                 2175             


Gly Glu  Ala Asp Glu Ser Gly  Arg Arg Pro Val Thr  Val Phe Ser 
    2180                 2185                 2190             


Gln Ala  Asp Gly Thr Asp Ala  Trp Thr Arg His Val  Thr Ala Thr 
    2195                 2200                 2205             


Ile Gly  Arg Ala Ala Ser Leu  Pro Asp Pro Val Ala  Trp Pro Pro 
    2210                 2215                 2220             


Ala Gln  Ala Glu Pro Val Asp  Val Thr Gly Phe Tyr  Asp Glu Leu 
    2225                 2230                 2235             


Ala Ala  Ala Gly Tyr Glu Tyr  Gly Pro Ala Phe Gln  Gly Leu Arg 
    2240                 2245                 2250             


Ala Ala  Trp Ser Asp Gly Asp  Thr Val Tyr Ala Glu  Val Val Leu 
    2255                 2260                 2265             


Ala Glu  Glu Gln Ala His Glu  Val Asp Arg Tyr Ala  Val His Pro 
    2270                 2275                 2280             


Ala Leu  Leu Asp Ala Ala Leu  Gln Ala Gly Met Val  Asn Thr Ala 
    2285                 2290                 2295             


Gly Thr  Gly Gln Gly Val Arg  Leu Pro Phe Ser Trp  Asn Gly Ile 
    2300                 2305                 2310             


Gln Val  His Ser Thr Gly Ala  Thr Thr Leu Arg Val  Ala Ala Thr 
    2315                 2320                 2325             


Pro Leu  Ala Asp Gly Trp Ser  Val Arg Ala Ala Ala  Asp Asn Gly 
    2330                 2335                 2340             


Arg Pro  Val Ala Thr Ile Gly  Ser Leu Val Thr Arg  Pro Val Thr 
    2345                 2350                 2355             


Thr Asp  Met Leu Gly Ser Thr  Thr Asp Asp Leu Phe  Ala Val Val 
    2360                 2365                 2370             


Trp Thr  Glu Ile Thr Ala Pro  Glu Pro Gly Asp Pro  Ser Asp Val 
    2375                 2380                 2385             


Gly Val  Phe Thr Ala Leu Pro  Glu Ala Gly Gly Asp  Pro Leu Thr 
    2390                 2395                 2400             


Gln Thr  Arg Ala Leu Thr Ala  Gln Val Leu Gln Thr  Val Gln Gln 
    2405                 2410                 2415             


Trp Leu  Ala Gly Glu Asp Arg  Pro Leu Val Val Arg  Thr Gly Thr 
    2420                 2425                 2430             


Asp Leu  Ala Ser Ala Ala Val  Ser Gly Leu Val Arg  Ser Ala Gln 
    2435                 2440                 2445             


Ser Glu  His Pro Gly Arg Leu  Ile Leu Val Glu Ser  Asp Asp Glu 
    2450                 2455                 2460             


Leu Thr  Pro Glu Gln Leu Ala  Gly Thr Ala Gly Leu  Asp Glu Pro 
    2465                 2470                 2475             


Arg Ile  Arg Ile Asp Gly Gly  His Tyr Glu Val Pro  Arg Leu Ala 
    2480                 2485                 2490             


Arg Glu  Asp Ala Ser Leu Thr  Val Pro Glu Asp Arg  Ala Trp Leu 
    2495                 2500                 2505             


Leu Glu  Leu Pro Gly Ser Gly  Thr Leu Arg Asp Leu  Arg Val Ile 
    2510                 2515                 2520             


Pro Thr  Asp Thr Ala Glu Arg  Pro Leu Arg Trp Gly  Glu Val Arg 
    2525                 2530                 2535             


Val Gly  Val Arg Ala Gly Gly  Leu Asn Phe Arg Asp  Val Val Val 
    2540                 2545                 2550             


Ala Leu  Gly Met Val Thr Asp  Pro Arg Pro Ala Gly  Gly Glu Ala 
    2555                 2560                 2565             


Ala Gly  Val Val Leu Glu Thr  Gly Pro Gly Val Glu  Asp Leu Ser 
    2570                 2575                 2580             


Pro Gly  Asp Arg Val Phe Gly  Ile Leu Asp Gly Gly  Phe Gly Ser 
    2585                 2590                 2595             


Val Ala  Ile Ala Asp Arg Arg  Leu Leu Ala Val Ile  Pro Asp Gly 
    2600                 2605                 2610             


Trp Ser  Phe Thr Thr Ala Ala  Ser Ile Pro Val Val  Phe Ala Thr 
    2615                 2620                 2625             


Ala Tyr  Tyr Gly Leu Val Asp  Leu Ala Gly Leu Arg  Ala Gly Glu 
    2630                 2635                 2640             


Ser Val  Leu Ile His Ala Ala  Thr Gly Gly Val Gly  Met Ala Ala 
    2645                 2650                 2655             


Thr Gln  Ile Ala Arg His Leu  Gly Ala Glu Ile Tyr  Gly Thr Ala 
    2660                 2665                 2670             


Gly Ile  Ala Lys Gln His Val  Leu Arg Asp Ala Gly  Leu Gly Asp 
    2675                 2680                 2685             


Asp Arg  Ile Ala Asp Ser Arg  Thr Thr Gly Phe Arg  Glu Thr Phe 
    2690                 2695                 2700             


Arg Asp  Ser Thr Gln Gly Arg  Gly Val Asp Val Val  Leu Asn Ser 
    2705                 2710                 2715             


Leu Ser  Gly Asp Phe Val Asp  Ala Ser Leu Asp Val  Leu Ala Glu 
    2720                 2725                 2730             


Gly Gly  Arg Phe Ile Glu Met  Gly Lys Thr Asp Ile  Arg Asp Ala 
    2735                 2740                 2745             


Glu Gln  Ile Thr His Ala Thr  Tyr Arg Ala Phe Asp  Leu Met Asp 
    2750                 2755                 2760             


Ala Gly  Pro Asp Arg Val Arg  Glu Ile Ile Ala Glu  Leu Leu Gly 
    2765                 2770                 2775             


Leu Phe  Glu Gln Gly Val Leu  Arg Pro Leu Pro Val  Gln Ala Trp 
    2780                 2785                 2790             


Asp Ile  Arg Gln Ala Arg Asp  Ala Phe Thr Trp Met  Ser Arg Ala 
    2795                 2800                 2805             


Arg His  Ile Gly Lys Ile Val  Leu Thr Ile Pro Gln  Gln Leu Asp 
    2810                 2815                 2820             


Pro Asp  Gly Thr Val Leu Ile  Ser Gly Gly Ser Gly  Val Leu Ala 
    2825                 2830                 2835             


Gly Ile  Leu Ala Arg His Leu  Val Ala Glu Arg Gly  Val Arg His 
    2840                 2845                 2850             


Leu Leu  Leu Val Ser Arg Ser  Ala Pro Ser Glu Ala  Leu Ile Ser 
    2855                 2860                 2865             


Glu Leu  Thr Ala Leu Gly Ala  Gln Val Glu Thr Val  Ala Cys Asp 
    2870                 2875                 2880             


Val Ser  Asp Arg Val Ala Leu  Glu Gln Val Leu Asp  Gly Val Pro 
    2885                 2890                 2895             


Leu Thr  Ala Val Phe His Thr  Ala Ala Ala Leu Asp  Asp Gly Val 
    2900                 2905                 2910             


Val Glu  Ser Leu Thr Pro Gln  Arg Val Asp Thr Val  Leu Arg Pro 
    2915                 2920                 2925             


Lys Ala  Asp Ala Ala Trp Tyr  Leu His Glu Leu Thr  Arg Asp Ala 
    2930                 2935                 2940             


Asp Leu  Ala Ala Phe Val Met  Tyr Ser Ser Val Ala  Gly Ile Met 
    2945                 2950                 2955             


Gly Ala  Ala Gly Gln Gly Asn  Tyr Ala Ala Ala Asn  Ala Phe Leu 
    2960                 2965                 2970             


Asp Ala  Leu Ala Ala His Arg  Arg Arg Glu Gly Leu  Pro Ala Leu 
    2975                 2980                 2985             


Ser Leu  Ala Trp Gly Leu Trp  Glu Asp Ala Ser Gly  Leu Ser Ala 
    2990                 2995                 3000             


Gly Leu  Thr Glu Thr Asp His  Asp Arg Ile Arg Arg  Gly Gly Leu 
    3005                 3010                 3015             


Glu Ala  Ile Ala Ala Glu His  Gly Met Arg Leu Phe  Asp Thr Ala 
    3020                 3025                 3030             


Thr Arg  Gln Gly Glu Pro Val  Leu Leu Ala Ser Pro  Leu Asn Leu 
    3035                 3040                 3045             


Thr Arg  Gln Gly Glu Val Pro  Ala Leu Leu Arg Thr  Leu His Arg 
    3050                 3055                 3060             


Pro Val  Ala Arg Arg Ala Ala  Thr Ala Asn Gly Arg  Pro Ala Asp 
    3065                 3070                 3075             


Leu Thr  Pro Glu Ala Leu Leu  Lys Leu Val Cys Gly  Arg Ala Ala 
    3080                 3085                 3090             


Ala Val  Leu Gly His Val Asp  Ala Asp Ala Val Pro  Val Ala Val 
    3095                 3100                 3105             


Ala Phe  Arg Asp Leu Gly Val  Asp Ser Leu Thr Ala  Val Glu Leu 
    3110                 3115                 3120             


Arg Asn  Ser Leu Ala Lys Ala  Thr Gly Leu Arg Leu  Pro Ala Thr 
    3125                 3130                 3135             


Leu Val  Phe Asp Tyr Pro Thr  Pro Thr Val Leu Ala  Gly Arg Leu 
    3140                 3145                 3150             


Gly Glu  Leu Leu Ala Gly Gly  Thr Ala Pro Val Arg  Ala Ala Val 
    3155                 3160                 3165             


Val Arg  Arg Ala Ala Ala Ser  Asp Glu Pro Leu Ala  Ile Val Gly 
    3170                 3175                 3180             


Met Ala  Cys Arg Leu Pro Gly  Gly Val Leu Ser Pro  Glu Asp Leu 
    3185                 3190                 3195             


Trp Arg  Leu Val Glu Ser Gly  Gly Asp Ala Ile Ser  Gly Phe Pro 
    3200                 3205                 3210             


Val Asp  Arg Gly Trp Asp Val  Glu Asn Leu Phe Asp  Pro Asp Pro 
    3215                 3220                 3225             


Asp Ala  Ala Gly Arg Thr Tyr  Ala Val Arg Gly Gly  Phe Leu Asp 
    3230                 3235                 3240             


Gly Ala  Ala Gly Phe Asp Ala  Ser Phe Phe Gly Ile  Ser Pro Arg 
    3245                 3250                 3255             


Glu Ala  Gln Ala Met Asp Pro  Gln Gln Arg Leu Val  Leu Glu Val 
    3260                 3265                 3270             


Ser Trp  Glu Ala Phe Glu Arg  Ala Gly Ile Glu Pro  Gly Ser Val 
    3275                 3280                 3285             


Arg Gly  Ser Asp Thr Gly Val  Phe Met Gly Ala Tyr  Pro Gly Gly 
    3290                 3295                 3300             


Tyr Gly  Val Gly Thr Asp Leu  Gly Gly Phe Gly Met  Thr Ser Val 
    3305                 3310                 3315             


Ala Val  Ser Val Leu Ala Gly  Arg Val Ser Tyr Phe  Phe Gly Leu 
    3320                 3325                 3330             


Glu Gly  Pro Ala Met Thr Val  Asp Thr Ala Cys Ser  Ser Ser Leu 
    3335                 3340                 3345             


Val Ala  Leu His Gln Ala Gly  Ser Ala Leu Arg Gln  Gly Glu Cys 
    3350                 3355                 3360             


Ser Leu  Ala Leu Val Gly Gly  Val Thr Val Met Pro  Thr Pro Gln 
    3365                 3370                 3375             


Thr Phe  Val Glu Phe Ser Arg  Gln Arg Gly Leu Ala  Ala Asp Gly 
    3380                 3385                 3390             


Arg Cys  Lys Ala Phe Ala Asp  Ala Ala Asp Gly Thr  Gly Phe Ser 
    3395                 3400                 3405             


Glu Gly  Val Gly Val Leu Leu  Val Glu Arg Leu Ser  Asp Ala Gln 
    3410                 3415                 3420             


Ala Arg  Gly His Asn Ile Leu  Ala Val Val Arg Gly  Ser Ala Val 
    3425                 3430                 3435             


Asn Gln  Asp Gly Ala Ser Asn  Gly Leu Thr Ala Pro  Asn Gly Pro 
    3440                 3445                 3450             


Ser Gln  Gln Arg Val Ile Arg  Gln Ala Leu Ala Asn  Ala Gly Leu 
    3455                 3460                 3465             


Ala Gly  Ala Glu Val Asp Val  Val Glu Ala His Gly  Thr Gly Thr 
    3470                 3475                 3480             


Thr Leu  Gly Asp Pro Ile Glu  Ala Gln Ala Val Ile  Ala Thr Tyr 
    3485                 3490                 3495             


Gly Gln  Asp Arg Asp Gln Pro  Val Leu Leu Gly Ser  Leu Lys Ser 
    3500                 3505                 3510             


Asn Leu  Gly His Thr Gln Ala  Ala Ala Gly Val Ser  Gly Val Ile 
    3515                 3520                 3525             


Lys Met  Val Met Ala Leu Arg  His Asp Thr Val Pro  Ala Thr Leu 
    3530                 3535                 3540             


His Ile  Asp Glu Pro Ser Arg  His Ile Asp Trp Thr  Ala Gly Ala 
    3545                 3550                 3555             


Val Glu  Leu Val Thr Glu Asn  Gln Ser Trp Pro Glu  Thr Gly Arg 
    3560                 3565                 3570             


Ala Arg  Arg Ala Ala Val Ser  Ser Phe Gly Ile Ser  Gly Thr Asn 
    3575                 3580                 3585             


Ala His  Val Ile Leu Glu Ser  Ala Pro Ala Gln Pro  Val Pro Leu 
    3590                 3595                 3600             


Val Asp  Thr Pro Val Ser Ala  Val Thr Ala Gly Val  Val Pro Leu 
    3605                 3610                 3615             


Pro Ile  Ser Ala Arg Thr Val  Pro Ala Leu Ala Asp  Leu Glu Asp 
    3620                 3625                 3630             


Arg Leu  Arg Ala Tyr Leu Thr  Thr Thr Pro Glu Thr  Asp Leu Pro 
    3635                 3640                 3645             


Ala Val  Ala Ser Thr Leu Ala  Val Thr Arg Ser Val  Phe Glu His 
    3650                 3655                 3660             


Arg Ala  Val Leu Leu Gly Glu  Glu Thr Val Thr Gly  Ile Ala Val 
    3665                 3670                 3675             


Ser Asp  Pro Arg Val Val Phe  Val Phe Ser Gly Gln  Gly Ser Gln 
    3680                 3685                 3690             


Arg Val  Gly Met Gly Glu Glu  Leu Ala Ala Ala Phe  Pro Leu Phe 
    3695                 3700                 3705             


Ala Arg  Leu His Arg Gln Val  Trp Asp Leu Leu Asp  Val Pro Asp 
    3710                 3715                 3720             


Leu Glu  Val Asp Asp Thr Gly  Tyr Val Gln Pro Ala  Leu Phe Ala 
    3725                 3730                 3735             


Leu Gln  Val Ala Leu Phe Gly  Leu Leu Glu Ser Trp  Gly Val Arg 
    3740                 3745                 3750             


Pro Glu  Ala Val Ile Gly His  Ser Val Gly Glu Val  Ala Ala Gly 
    3755                 3760                 3765             


Tyr Val  Ala Gly Val Trp Ser  Leu Glu Asp Ala Cys  Thr Leu Val 
    3770                 3775                 3780             


Ser Ala  Arg Ala Arg Leu Met  Gln Ala Leu Pro Ala  Gly Gly Ala 
    3785                 3790                 3795             


Met Val  Ala Val Pro Val Ser  Glu Glu Arg Ala Arg  Ala Val Leu 
    3800                 3805                 3810             


Val Asp  Gly Val Glu Ile Ala  Ala Val Asn Gly Pro  Ala Ser Val 
    3815                 3820                 3825             


Val Leu  Ser Gly Asp Glu Ser  Ala Val Leu Arg Val  Ala Glu Gly 
    3830                 3835                 3840             


Leu Gly  Arg Trp Thr Arg Leu  Ser Ala Ser His Ala  Phe His Ser 
    3845                 3850                 3855             


Val Arg  Met Glu Pro Met Leu  Glu Glu Phe Arg Gln  Val Ala Ser 
    3860                 3865                 3870             


Glu Leu  Thr Tyr Arg Glu Pro  Arg Ile Val Met Ala  Ala Gly Glu 
    3875                 3880                 3885             


Gln Val  Thr Thr Pro Glu Tyr  Trp Val Arg Gln Val  Arg Asp Thr 
    3890                 3895                 3900             


Val Arg  Phe Gly Asp Gln Val  Ala Ala Phe Gly Asp  Ala Val Phe 
    3905                 3910                 3915             


Leu Glu  Ile Gly Pro Asp Arg  Thr Leu Ser Arg Leu  Ile Asp Gly 
    3920                 3925                 3930             


Ile Pro  Thr Leu His Gly Asp  Asp Glu Gln His Ala  Val Val Ala 
    3935                 3940                 3945             


Ala Leu  Ala Glu Leu His Val  Gln Gly Val Pro Ile  Asp Trp Ser 
    3950                 3955                 3960             


Ser Ile  Leu Gly Ala Asn Pro  Ala Arg Val Leu Asp  Leu Pro Thr 
    3965                 3970                 3975             


Tyr Ala  Phe Gln His Glu Arg  Tyr Trp Met Val Ser  Thr Gly Arg 
    3980                 3985                 3990             


Val Gly  Gly Glu Gly His Pro  Leu Leu Gly Trp Gly  Val Pro Val 
    3995                 4000                 4005             


Ala Glu  Ala Gly Gly Arg Leu  Tyr Thr Gly Arg Val  Ala Arg Gln 
    4010                 4015                 4020             


Asp Gly  Pro Val Leu Ser Val  Ala Ala Phe Val Glu  Met Ala Phe 
    4025                 4030                 4035             


Ala Ala  Ala Gly Gly Arg Pro  Ile Arg Glu Leu Ser  Val Asp Ala 
    4040                 4045                 4050             


Leu Leu  Tyr Ile Pro Asp Asp  Gly Thr Ala Glu Leu  Gln Thr Trp 
    4055                 4060                 4065             


Val Ser  Glu His Arg Leu Thr  Ile His Ala Arg Tyr  Arg Asp Thr 
    4070                 4075                 4080             


Glu Pro  Trp Thr Arg Leu Ala  Thr Ala Ala Leu Asp  Thr Thr Ala 
    4085                 4090                 4095             


Pro Ala  Thr Thr His Thr Pro  His Pro Gly Leu Ile  Thr Thr Ala 
    4100                 4105                 4110             


Leu Thr  Leu Thr Gly Asp Glu  Ala Pro Ala Ile Trp  His Asp Leu 
    4115                 4120                 4125             


Thr Leu  His Thr Ser Asn Ala  Thr Glu Leu His Thr  His Ile Thr 
    4130                 4135                 4140             


Pro Gly  Asp Asp Gly Thr Leu  Thr Ile Thr Ala Thr  Asp Thr Thr 
    4145                 4150                 4155             


Gly Gln  Pro Val Leu Thr Ala  His Thr Ala Thr Pro  Thr Thr Ile 
    4160                 4165                 4170             


Pro Val  His Thr Pro Thr Thr  Pro Ala Asp Asp Leu  Leu Thr Leu 
    4175                 4180                 4185             


Thr Trp  Thr Gln Ile Pro Thr  Pro Gly Pro Gly Asp  Pro Thr Asp 
    4190                 4195                 4200             


Ile Ala  Val Cys Thr Ala Leu  Pro Asp Pro Asp Gly  Asp Pro Leu 
    4205                 4210                 4215             


Ala Gln  Thr Arg Thr Leu Thr  Ala Gln Val Leu Gln  Ser Ile Gln 
    4220                 4225                 4230             


Thr Thr  Leu Thr Gly Glu Asp  Arg Pro Leu Val Val  His Thr Gly 
    4235                 4240                 4245             


Thr Gly  Leu Ala Ser Ala Ala  Val Ser Gly Leu Val  Arg Ser Ala 
    4250                 4255                 4260             


Gln Ser  Glu His Pro Asp Arg  Phe Ile Leu Val Glu  Ser Asp Asp 
    4265                 4270                 4275             


Ser Leu  Pro Gln Ala Gln Leu  Ala Ala Val Ala Gly  Leu Asp Glu 
    4280                 4285                 4290             


Pro Trp  Leu Arg Ile Thr Gly  Ser Cys Tyr Glu Val  Pro Arg Leu 
    4295                 4300                 4305             


Thr Lys  Thr Thr Thr Ala Thr  Ala Thr Ala Val Ser  Glu Pro Val 
    4310                 4315                 4320             


Trp Asn  Pro Asp Gly Thr Val  Leu Ile Thr Gly Gly  Ser Gly Ala 
    4325                 4330                 4335             


Leu Ala  Gly Ile Leu Ala Arg  His Leu Val Thr Glu  Arg Gly Val 
    4340                 4345                 4350             


Arg His  Leu Leu Leu Ile Ser  Arg Ser Thr Pro Ser  Thr Thr Leu 
    4355                 4360                 4365             


Thr Asp  Glu Leu Arg Glu Leu  Gly Ala His Val Asp  Val Ala Ala 
    4370                 4375                 4380             


Cys Asp  Val Ser Asp Arg Asp  Ala Leu Ala Arg Val  Leu Asp Gly 
    4385                 4390                 4395             


Val Asp  Leu Thr Ala Val Phe  His Thr Ala Gly Ala  Leu Asp Asp 
    4400                 4405                 4410             


Gly Val  Val Glu Ser Leu Thr  Pro Gln Arg Leu Asp  Thr Val Leu 
    4415                 4420                 4425             


Thr Pro  Lys Ala Asp Gly Ala  Trp His Leu His Glu  Leu Thr Arg 
    4430                 4435                 4440             


Asp Arg  Asp Leu Thr Ala Phe  Val Met Tyr Ser Ser  Ala Ala Gly 
    4445                 4450                 4455             


Val Met  Gly Ala Ala Gly Gln  Gly Asn Tyr Ala Ala  Ala Asn Ala 
    4460                 4465                 4470             


Phe Leu  Asp Ala Leu Ala Glu  His Arg His Ala Asp  Gly Leu Pro 
    4475                 4480                 4485             


Ala Leu  Ser Leu Ala Trp Gly  Met Trp Asp Asp Thr  Asp Gly Met 
    4490                 4495                 4500             


Thr Ala  Ser Leu Ser Gly Thr  Asp His Arg Arg Ile  Arg Arg Ser 
    4505                 4510                 4515             


Gly Gln  Arg Ala Ile Thr Ala  Glu His Gly Met Arg  Leu Leu Asp 
    4520                 4525                 4530             


Lys Ala  Ser Gly Arg Ser Glu  Pro Val Leu Val Ala  Thr Ala Met 
    4535                 4540                 4545             


Asn Pro  Ile Pro Asp Thr Asp  Leu Pro Ala Leu Leu  Arg Ser Leu 
    4550                 4555                 4560             


Tyr Pro  Lys Thr Ala Arg Lys  Ser Gln Pro Ile Gln  Glu Leu Ser 
    4565                 4570                 4575             


Pro Glu  Ala Leu Leu Lys Ile  Val Arg Asp Ser Ala  Ala Leu Met 
    4580                 4585                 4590             


Leu Gly  His Pro Asn Thr Asp  Ala Ile Ala Ala Thr  Thr Ala Phe 
    4595                 4600                 4605             


Arg Asp  Leu Gly Val Asp Ser  Leu Ile Ala Val Glu  Leu Arg Asn 
    4610                 4615                 4620             


Ser Leu  Ala Lys Ala Thr Gly  Leu Arg Leu Pro Ala  Thr Leu Val 
    4625                 4630                 4635             


Phe Asp  Tyr Pro Thr Pro Thr  Val Leu Ala Gly Arg  Leu Gly Glu 
    4640                 4645                 4650             


Leu Leu  Ala Gly Val Thr Pro  Gln Arg His Ala Thr  Val Arg Thr 
    4655                 4660                 4665             


Gly Thr  Ala Ser Asp Glu Pro  Leu Ala Ile Val Gly  Met Ala Cys 
    4670                 4675                 4680             


Arg Leu  Pro Gly Gly Val Ser  Ser Pro Glu Asp Leu  Trp Arg Leu 
    4685                 4690                 4695             


Val Glu  Ser Gly Thr Asp Ala  Ile Thr Asp Phe Pro  Thr Asp Arg 
    4700                 4705                 4710             


Gly Trp  Asp Thr Asp Asp Leu  Phe Asp Pro Asp Pro  Asp Thr Ala 
    4715                 4720                 4725             


Gly Lys  Thr Tyr Thr Val His  Gly Gly Phe Leu Asp  Asp Val Ala 
    4730                 4735                 4740             


Gly Phe  Asp Ala Ser Phe Phe  Gly Ile Ser Pro Arg  Glu Ala Gln 
    4745                 4750                 4755             


Ala Met  Asp Pro Gln Gln Arg  Leu Val Leu Glu Ala  Ala Trp Glu 
    4760                 4765                 4770             


Ala Phe  Glu Arg Ala Gly Ile  Glu Pro Gly Ser Val  Arg Gly Ser 
    4775                 4780                 4785             


Asp Thr  Gly Val Phe Met Gly  Ala Tyr Pro Gly Gly  Tyr Gly Ile 
    4790                 4795                 4800             


Gly Ala  Asp Leu Gly Gly Phe  Gly Ala Thr Ala Gly  Ala Gly Ser 
    4805                 4810                 4815             


Val Leu  Ser Gly Arg Leu Ser  Tyr Phe Phe Gly Leu  Glu Gly Pro 
    4820                 4825                 4830             


Ala Met  Thr Val Asp Thr Ala  Cys Ser Ser Ser Leu  Val Ala Leu 
    4835                 4840                 4845             


His Gln  Ala Gly Ser Ala Leu  Arg Gln Gly Glu Cys  Ser Leu Ala 
    4850                 4855                 4860             


Leu Val  Gly Gly Val Thr Val  Ile Ala Asn Pro Gln  Ile Phe Val 
    4865                 4870                 4875             


Glu Phe  Ser Arg Gln Arg Gly  Leu Ala Ala Asp Gly  Arg Cys Lys 
    4880                 4885                 4890             


Ala Phe  Ala Asp Ser Ala Asp  Gly Thr Gly Trp Ser  Glu Gly Val 
    4895                 4900                 4905             


Gly Val  Leu Leu Val Glu Arg  Leu Ser Asp Ala Gln  Ala Arg Gly 
    4910                 4915                 4920             


His Asn  Ile Leu Ala Val Val  Arg Gly Ser Ala Val  Asn Gln Asp 
    4925                 4930                 4935             


Gly Ala  Ser Asn Gly Leu Thr  Ala Pro Asn Gly Pro  Ser Gln Gln 
    4940                 4945                 4950             


Arg Val  Ile Arg Gln Ala Leu  Ala Asn Ala Gly Leu  Ala Gly Ala 
    4955                 4960                 4965             


Glu Val  Asp Val Val Glu Ala  His Gly Thr Gly Thr  Thr Leu Gly 
    4970                 4975                 4980             


Asp Pro  Ile Glu Ala Gln Ala  Val Ile Ala Thr Tyr  Gly Gln Asp 
    4985                 4990                 4995             


Arg Asp  Gln Ser Val Leu Leu  Gly Ser Leu Lys Ser  Asn Leu Gly 
    5000                 5005                 5010             


His Thr  Gln Ala Ala Ala Gly  Val Ser Gly Val Ile  Lys Met Val 
    5015                 5020                 5025             


Met Ala  Leu Gln Asn Gly Val  Val Pro Arg Thr Leu  His Ala Asp 
    5030                 5035                 5040             


Gln Pro  Ser Arg His Ile Asp  Trp Thr Ala Gly Ala  Val Glu Leu 
    5045                 5050                 5055             


Val Thr  Glu Asn Gln Pro Trp  Pro Glu Leu Asp Arg  Pro Arg Arg 
    5060                 5065                 5070             


Ala Ala  Val Ser Ala Phe Gly  Val Ser Gly Thr Asn  Ala His Val 
    5075                 5080                 5085             


Ile Leu  Glu Ser Ala Pro Asp  Gln Pro Val Pro Leu  Val Asp Thr 
    5090                 5095                 5100             


Pro Val  Ser Ala Val Thr Ala  Gly Val Val Pro Leu  Pro Ile Ser 
    5105                 5110                 5115             


Ala Arg  Thr Val Pro Ala Leu  Ala Asp Leu Glu Asp  Gln Leu Arg 
    5120                 5125                 5130             


Ala Tyr  Leu Thr Thr Ala Pro  Glu Thr Asp Leu Pro  Ala Val Ala 
    5135                 5140                 5145             


Ser Thr  Leu Ala Thr Thr Arg  Ser Val Phe Glu His  Arg Ala Val 
    5150                 5155                 5160             


Leu Leu  Gly Glu Asp Thr Val  Thr Gly Thr Ala Ile  Pro Asp Pro 
    5165                 5170                 5175             


Arg Ile  Val Phe Val Phe Ser  Gly Gln Gly Ser Gln  Arg Ala Gly 
    5180                 5185                 5190             


Met Gly  Glu Glu Leu Ala Ala  Ala Phe Pro Leu Phe  Ala Arg Leu 
    5195                 5200                 5205             


His Arg  Gln Val Trp Asp Leu  Leu Asp Val Pro Asp  Leu Asp Val 
    5210                 5215                 5220             


Asp Asp  Thr Gly Tyr Val Gln  Pro Ala Leu Phe Ala  Leu Gln Val 
    5225                 5230                 5235             


Ala Leu  Phe Gly Leu Leu Glu  Ser Trp Gly Val Arg  Pro Arg Ala 
    5240                 5245                 5250             


Val Ile  Gly His Ser Val Gly  Glu Val Ala Ala Gly  Tyr Val Ala 
    5255                 5260                 5265             


Gly Val  Trp Ser Leu Glu Asp  Ala Cys Ala Leu Val  Ser Ala Arg 
    5270                 5275                 5280             


Ala Arg  Leu Met Gln Ala Leu  Pro Ala Gly Gly Ala  Met Val Ala 
    5285                 5290                 5295             


Val Pro  Val Ser Glu Glu Arg  Ala Arg Ala Val Leu  Val Asp Gly 
    5300                 5305                 5310             


Val Glu  Ile Ala Ala Val Asn  Gly Pro Ala Ser Val  Val Leu Ser 
    5315                 5320                 5325             


Gly Asp  Glu Ala Ala Val Leu  Arg Val Ala Glu Gly  Leu Gly Arg 
    5330                 5335                 5340             


Trp Thr  Arg Leu Ser Ala Ser  His Ala Phe His Ser  Val Arg Met 
    5345                 5350                 5355             


Glu Pro  Met Leu Glu Glu Phe  Arg Gln Val Val Ser  Arg Leu Thr 
    5360                 5365                 5370             


Tyr Arg  Glu Pro Arg Ile Val  Met Ala Ala Gly Glu  Gln Val Thr 
    5375                 5380                 5385             


Thr Pro  Glu Tyr Trp Val Arg  Gln Val Arg Glu Thr  Val Arg Phe 
    5390                 5395                 5400             


Gly Asp  Gln Val Ala Ala Phe  Gly Asp Ala Val Phe  Leu Glu Ile 
    5405                 5410                 5415             


Gly Pro  Asp Arg Thr Leu Ser  Arg Leu Ile Asp Gly  Ile Ala Met 
    5420                 5425                 5430             


Leu Asp  Gly Asp Asp Glu Val  Arg Ala Ala Val Ala  Ala Leu Ala 
    5435                 5440                 5445             


Met Met  His Val Gln Gly Val  Gly Val Asp Trp Pro  Ala Ile Leu 
    5450                 5455                 5460             


Gly Thr  Thr Thr Gly Arg Val  Leu Asp Leu Pro Thr  Tyr Ala Phe 
    5465                 5470                 5475             


Gln His  Glu Arg Tyr Trp Met  Ala Asn Ala Asp Glu  Gly His Pro 
    5480                 5485                 5490             


Leu Leu  Gly Lys Val Glu His  Pro Leu Leu Gly Ser  Val Met Ala 
    5495                 5500                 5505             


Leu Pro  Asn Ser Asp Gly Val  Val Leu Thr Gly Arg  Ile Ser Leu 
    5510                 5515                 5520             


Ala Thr  His Ala Trp Leu Ala  Asp His Val Val Arg  Gly Thr Val 
    5525                 5530                 5535             


Leu Leu  Pro Gly Thr Gly Phe  Val Glu Met Val Ala  Arg Ala Ala 
    5540                 5545                 5550             


Ala Glu  Val Gly Cys Gly Val  Ile Asp Glu Leu Leu  Ile Glu Ala 
    5555                 5560                 5565             


Pro Leu  Leu Leu Pro Glu His  Gly Gly Val His Leu  Ser Val Ser 
    5570                 5575                 5580             


Val Gly  Glu Ala Asp Gly Ala  Gly Arg Arg Pro Val  Thr Val Phe 
    5585                 5590                 5595             


Ala Gln  Ala Asp Asp Ala Glu  Val Trp Val Arg Gln  Val Thr Ala 
    5600                 5605                 5610             


Thr Ile  Ser Pro Ala Gly Pro  Ala Val Ser Leu Pro  Glu Leu Glu 
    5615                 5620                 5625             


Val Trp  Pro Pro Val Gln Ala  Glu Pro Val Asp Val  Ser Thr Phe 
    5630                 5635                 5640             


Tyr Glu  Arg Leu Ala Arg Ala  Asp Trp Gln Trp Gly  Pro Ala Phe 
    5645                 5650                 5655             


Gln Gly  Leu Arg Ala Ala Trp  Arg Asp Gly Asp Thr  Ile Tyr Ala 
    5660                 5665                 5670             


Glu Ile  Val Leu Ala Asp Glu  Glu Ala Arg Glu Ala  Asp Gln Phe 
    5675                 5680                 5685             


Leu Val  His Pro Ala Leu Leu  Asp Ala Ala Leu Gln  Thr Ser Val 
    5690                 5695                 5700             


Leu Lys  Thr Pro Asp Asp Leu  Arg Leu Pro Phe Ser  Trp Asn Gln 
    5705                 5710                 5715             


Ile Glu  Phe His Ala Thr Gly  Ala Ala Ile Leu Arg  Val Ala Val 
    5720                 5725                 5730             


Thr Pro  Val Ala Asp Arg Trp  Ile Val His Ala Ala  Asp Ser Thr 
    5735                 5740                 5745             


Gly Arg  Pro Val Ala Thr Ile  Gly Ala Leu Val Ser  Arg Pro Val 
    5750                 5755                 5760             


Thr Ala  Glu Thr Leu Gly Ser  Asn Thr Asp Asp Leu  Phe Ala Leu 
    5765                 5770                 5775             


Thr Trp  Thr Glu Ile Pro Thr  Pro Gly Pro Gly Asp  Pro Ala Asp 
    5780                 5785                 5790             


Val Ala  Val Cys Thr Ala Leu  Pro Glu Pro Asp Ser  Asp Pro Leu 
    5795                 5800                 5805             


Thr Gln  Thr Arg Thr Leu Thr  Ala Gln Val Leu Gln  Ser Ile Gln 
    5810                 5815                 5820             


Thr Ser  Leu Thr Gly Glu Asp  Arg Pro Leu Val Val  His Thr Gly 
    5825                 5830                 5835             


Thr Gly  Leu Ala Ser Ala Ala  Val Ser Gly Leu Val  Arg Ser Ala 
    5840                 5845                 5850             


Gln Ser  Glu His Pro Asp Arg  Phe Ile Leu Val Glu  Cys Asp Asp 
    5855                 5860                 5865             


Glu Thr  Leu Thr Pro Asp Gln  Leu Ala Ala Thr Ala  Gly Leu Asp 
    5870                 5875                 5880             


Glu Pro  Trp Leu Arg Ile Thr  Gly Gly His Tyr Glu  Val Pro Arg 
    5885                 5890                 5895             


Leu Thr  Lys Thr Thr Thr Ala  Ala Ala Thr Thr Val  Ser Glu Pro 
    5900                 5905                 5910             


Val Trp  Asp Pro Asp Gly Thr  Val Leu Ile Thr Gly  Gly Ser Gly 
    5915                 5920                 5925             


Ala Leu  Ala Gly Ile Leu Ala  Arg His Leu Val Thr  Glu Arg Ser 
    5930                 5935                 5940             


Val Arg  His Leu Leu Leu Ile  Ser Arg Ser Thr Pro  Ser Thr Thr 
    5945                 5950                 5955             


Leu Ile  Asn Glu Leu Arg Glu  Leu Gly Ala His Ile  Glu Thr Ala 
    5960                 5965                 5970             


Ala Cys  Asp Val Ser Asp Arg  Asp Ala Leu Ala Arg  Val Leu Asp 
    5975                 5980                 5985             


Gly Val  Asp Leu Thr Ala Val  Phe His Thr Ala Gly  Ala Leu Asp 
    5990                 5995                 6000             


Asp Gly  Val Val Glu Ser Leu  Thr Pro Gln Arg Leu  Asp Thr Val 
    6005                 6010                 6015             


Leu Met  Pro Lys Ala Asp Ala  Ala Trp His Leu His  Glu Leu Thr 
    6020                 6025                 6030             


Arg Asp  Arg Asp Leu Ala Ala  Phe Val Met Tyr Ser  Ser Ala Ala 
    6035                 6040                 6045             


Gly Val  Met Gly Ala Ala Gly  Gln Gly Asn Tyr Ala  Ala Ala Asn 
    6050                 6055                 6060             


Ala Phe  Leu Asp Ala Leu Ala  Glu His Arg Arg Ala  Asp Gly Leu 
    6065                 6070                 6075             


Pro Ala  Leu Ser Leu Ala Trp  Gly Met Trp Asp Asp  Ala Asp Gly 
    6080                 6085                 6090             


Met Thr  Ala Ser Leu Ser Gly  Thr Asp His Arg Arg  Ile Arg Arg 
    6095                 6100                 6105             


Ser Gly  Gln Arg Ala Ile Thr  Ala Glu His Gly Met  Arg Leu Leu 
    6110                 6115                 6120             


Asp Lys  Ala Ser Gly Arg Ser  Glu Pro Val Leu Val  Ala Thr Ala 
    6125                 6130                 6135             


Met Asn  Pro Ala Gly Glu Gly  Glu Val Pro Ala Leu  Leu Arg Thr 
    6140                 6145                 6150             


Leu His  Arg Pro Val Ala Arg  Arg Ala Ala Thr Thr  Asn Gly Arg 
    6155                 6160                 6165             


Pro Ala  Asp Leu Thr Pro Glu  Ala Leu Leu Lys Val  Val Arg Asp 
    6170                 6175                 6180             


Ser Ala  Ala Val Val Leu Gly  His Ala Ser Ala Asp  Thr Val Pro 
    6185                 6190                 6195             


Ala Ala  Thr Ala Phe Gln Glu  Leu Gly Leu Asp Ser  Leu Ile Ala 
    6200                 6205                 6210             


Val Glu  Leu Arg Asn Ser Leu  Ala Lys Ala Thr Gly  Leu Arg Leu 
    6215                 6220                 6225             


Pro Ala  Thr Met Val Phe Asp  Tyr Pro Thr Pro Ala  Ala Leu Ala 
    6230                 6235                 6240             


Gly Arg  Leu Gly Glu Leu Leu  Ala Gly Glu Thr Thr  Pro Ala Thr 
    6245                 6250                 6255             


Ala Ala  Val Val Arg Arg Ala  Thr Ala Ser Asp Glu  Pro Leu Ala 
    6260                 6265                 6270             


Ile Val  Gly Met Ala Cys Arg  Leu Pro Gly Gly Val  Ser Ser Pro 
    6275                 6280                 6285             


Glu Asp  Leu Trp Arg Leu Val  Glu Ser Gly Phe Asp  Ala Ile Thr 
    6290                 6295                 6300             


Gly Phe  Pro Thr Asp Arg Gly  Trp Asp Val Asp Asn  Leu Tyr Asp 
    6305                 6310                 6315             


Pro Asp  Pro Asp Ala Pro Gly  Lys Ser Thr Thr Leu  His Gly Gly 
    6320                 6325                 6330             


Phe Leu  Asp Asp Val Ala Gly  Phe Asp Ala Ser Phe  Phe Gly Ile 
    6335                 6340                 6345             


Ser Pro  Arg Glu Ala Val Ala  Met Asp Pro Gln Gln  Arg Leu Ala 
    6350                 6355                 6360             


Met Glu  Val Ser Trp Glu Ala  Phe Glu Arg Ala Gly  Ile Glu Pro 
    6365                 6370                 6375             


Gly Ser  Val Arg Gly Ser Asp  Thr Gly Val Phe Met  Gly Ala Tyr 
    6380                 6385                 6390             


Pro Gly  Gly Tyr Gly Ile Gly  Ala Glu Leu Gly Gly  Phe Met Leu 
    6395                 6400                 6405             


Thr Gly  Arg Ala Gly Ser Val  Leu Ala Gly Arg Val  Ser Tyr Phe 
    6410                 6415                 6420             


Phe Gly  Leu Glu Gly Pro Ala  Met Thr Val Asp Thr  Ala Cys Ser 
    6425                 6430                 6435             


Ser Ser  Leu Val Ala Leu His  Gln Ala Ala Tyr Ala  Leu Arg Gln 
    6440                 6445                 6450             


Gly Glu  Cys Ser Leu Ala Leu  Val Gly Gly Val Thr  Val Met Pro 
    6455                 6460                 6465             


Thr Pro  Val Met Phe Val Glu  Phe Ser Gln Gln Gln  Asn Leu Ala 
    6470                 6475                 6480             


Asp Asp  Gly Arg Cys Lys Ala  Phe Ala Asp Ser Ala  Asp Gly Thr 
    6485                 6490                 6495             


Gly Trp  Ser Glu Gly Val Gly  Val Leu Leu Val Glu  Arg Leu Ser 
    6500                 6505                 6510             


Asp Ala  Gln Ala Arg Gly His  Asn Ile Leu Ala Val  Val Arg Gly 
    6515                 6520                 6525             


Ser Ala  Val Asn Gln Asp Gly  Ala Ser Asn Gly Leu  Thr Ala Pro 
    6530                 6535                 6540             


Asn Gly  Pro Ser Gln Gln Arg  Val Ile Arg Ser Ala  Leu Thr Ser 
    6545                 6550                 6555             


Ala Gly  Leu Thr Thr Ala Asp  Val Asp Val Val Glu  Ala His Gly 
    6560                 6565                 6570             


Thr Gly  Thr Thr Leu Gly Asp  Pro Ile Glu Ala Gln  Ala Val Leu 
    6575                 6580                 6585             


Ala Thr  Tyr Gly Gln Asp Arg  Asp Gln Pro Val Leu  Leu Gly Ser 
    6590                 6595                 6600             


Leu Lys  Ser Asn Leu Gly His  Thr Gln Ala Ala Ala  Gly Val Ser 
    6605                 6610                 6615             


Gly Val  Ile Lys Met Val Met  Ala Leu Gln Asn Gly  Val Val Pro 
    6620                 6625                 6630             


Arg Thr  Leu His Val Glu Glu  Pro Ser Arg His Val  Asp Trp Thr 
    6635                 6640                 6645             


Ala Gly  Ala Val Glu Leu Val  Thr Glu Asn Gln Ser  Trp Pro Glu 
    6650                 6655                 6660             


Thr Gly  Arg Ala Arg Arg Ala  Ala Val Ser Ser Phe  Gly Phe Ser 
    6665                 6670                 6675             


Gly Thr  Asn Ala His Val Ile  Leu Glu Ser Ala Pro  Ala Gln Pro 
    6680                 6685                 6690             


Val Pro  Pro Met Asp Thr Pro  Ala Pro Ala Val Thr  Thr Gly Val 
    6695                 6700                 6705             


Val Pro  Leu Pro Ile Ser Ala  Lys Ser Leu Pro Ala  Leu Ala Asp 
    6710                 6715                 6720             


Leu Glu  Asp Gln Leu Arg Ala  Tyr Leu Thr Ala Thr  Pro Glu Thr 
    6725                 6730                 6735             


Asp Leu  Pro Ala Val Ala Ser  Thr Leu Ala Met Thr  Arg Ser Val 
    6740                 6745                 6750             


Phe Glu  His Arg Ala Val Leu  Leu Gly Glu Glu Thr  Val Thr Gly 
    6755                 6760                 6765             


Thr Ala  Ile Pro Asp Pro Arg  Ile Val Phe Val Phe  Ser Gly Gln 
    6770                 6775                 6780             


Gly Ser  Gln Arg Val Gly Met  Gly Glu Glu Leu Ala  Ala Ala Phe 
    6785                 6790                 6795             


Pro Leu  Phe Ala Arg Leu His  Arg Gln Val Trp Asp  Leu Leu Asp 
    6800                 6805                 6810             


Val Pro  Asp Leu Asp Val Asp  Asp Thr Gly Tyr Val  Gln Pro Ala 
    6815                 6820                 6825             


Leu Phe  Ala Leu Gln Val Ala  Leu Phe Gly Leu Leu  Glu Ser Trp 
    6830                 6835                 6840             


Gly Val  Arg Pro Arg Ala Val  Ile Gly His Ser Val  Gly Glu Val 
    6845                 6850                 6855             


Ala Ala  Gly Tyr Val Ala Gly  Val Trp Ser Leu Glu  Asp Ala Cys 
    6860                 6865                 6870             


Ala Leu  Val Ser Ala Arg Ala  Arg Leu Met Gln Ala  Leu Pro Ala 
    6875                 6880                 6885             


Gly Gly  Ala Met Val Ala Val  Pro Val Ser Glu Glu  Arg Ala Arg 
    6890                 6895                 6900             


Val Ala  Leu Val Asp Gly Val  Glu Ile Ala Ala Val  Asn Gly Pro 
    6905                 6910                 6915             


Ala Ser  Val Val Leu Ser Gly  Asp Glu Ala Ala Val  Leu Gln Ile 
    6920                 6925                 6930             


Ala Glu  Gly Leu Gly Arg Trp  Thr Arg Leu Ser Ala  Ser His Ala 
    6935                 6940                 6945             


Phe His  Ser Val Arg Met Glu  Pro Met Leu Glu Glu  Phe Gly Gln 
    6950                 6955                 6960             


Val Ala  Ser Glu Leu Thr Tyr  Gln Glu Pro Arg Ile  Val Met Ala 
    6965                 6970                 6975             


Ala Gly  Glu Gln Val Thr Thr  Pro Glu Tyr Trp Val  Arg Gln Val 
    6980                 6985                 6990             


Arg Asp  Thr Val Arg Phe Gly  Asp Gln Val Ala Ala  Phe Gly Asp 
    6995                 7000                 7005             


Ala Val  Phe Leu Glu Ile Gly  Pro Asp Arg Thr Leu  Ser Arg Leu 
    7010                 7015                 7020             


Ile Asp  Gly Ile Ala Met Leu  Asp Gly Asp Asp Glu  Val Arg Ala 
    7025                 7030                 7035             


Ala Val  Ala Ala Leu Ala Glu  Leu His Val Gln Gly  Val Pro Ile 
    7040                 7045                 7050             


Asp Trp  Pro Ala Val Leu Gly  Thr Thr Thr Gly Arg  Val Leu Asp 
    7055                 7060                 7065             


Leu Pro  Thr Tyr Ala Phe Gln  His Gln Arg Tyr Trp  Ala Ala Ser 
    7070                 7075                 7080             


Thr Asp  Arg Pro Ala Gly Asp  Gly His Pro Leu Leu  Asp Thr Val 
    7085                 7090                 7095             


Val Ala  Leu Pro Gly Ala Asp  Gly Val Val Leu Thr  Gly Arg Ile 
    7100                 7105                 7110             


Ser Leu  Ala Thr His Ala Trp  Leu Ala Asp His Ala  Val Arg Gly 
    7115                 7120                 7125             


Thr Val  Leu Leu Pro Gly Thr  Gly Phe Val Glu Met  Val Ala Arg 
    7130                 7135                 7140             


Ala Ala  Ala Glu Val Gly Cys  Ala Val Val Asp Glu  Leu Val Ile 
    7145                 7150                 7155             


Glu Ala  Pro Leu Leu Leu Pro  Ala Ser Gly Gly Val  Gln Leu Ser 
    7160                 7165                 7170             


Val Ser  Val Gly Glu Ala Asp  Asp Ala Gly His Arg  Pro Val Thr 
    7175                 7180                 7185             


Val His  Ser Gln Ala Asp Glu  Thr Glu Ala Trp Val  Arg His Val 
    7190                 7195                 7200             


Thr Ala  Thr Ile Ser Pro Ser  Gly Pro Ile Val Ser  Pro Pro Glu 
    7205                 7210                 7215             


Phe Glu  Val Trp Pro Pro Ala  Gln Ala Glu Pro Val  Glu Val Ala 
    7220                 7225                 7230             


Arg Phe  Tyr Asp Glu Leu Ala  Ala Ala Gly Tyr Glu  Tyr Gly Ala 
    7235                 7240                 7245             


Ala Phe  Gln Gly Leu Arg Ala  Ala Trp Arg Ala Gly  Glu Thr Ile 
    7250                 7255                 7260             


Tyr Ala  Glu Val Val Leu Ala  Glu Asp Gln Thr Leu  Glu Ala Ala 
    7265                 7270                 7275             


Arg Phe  Thr Val His Pro Ala  Leu Leu Asp Ala Ala  Leu Gln Ala 
    7280                 7285                 7290             


Asn Ile  Leu Asn Ala Ser Gly  Asp Leu Arg Leu Pro  Phe Ser Trp 
    7295                 7300                 7305             


Gly Gln  Val Gln Phe His Thr  Thr Gly Ala Ala Thr  Leu Arg Val 
    7310                 7315                 7320             


Ala Val  Thr Pro Val Ala Asp  Gly Trp Thr Ile Gln  Ala Thr Asp 
    7325                 7330                 7335             


Asp Ala  Gly Arg Pro Val Ala  Thr Val Gly Ser Val  Val Ala Arg 
    7340                 7345                 7350             


Pro Val  Ala Gly Leu Gly Ala  Thr Ala Glu Asp Leu  Phe Ala Leu 
    7355                 7360                 7365             


Thr Trp  Asn Glu Ile Pro Ala  Pro Gly Gln Gly Gly  Arg Thr Val 
    7370                 7375                 7380             


Gly Arg  Phe Glu Asp Leu Ala  Asp Asp Gly Pro Val  Pro Glu Leu 
    7385                 7390                 7395             


Val Val  Phe Thr Ala Leu Pro  Asp Val Asp Ala Asp  Pro Leu Val 
    7400                 7405                 7410             


Arg Thr  Arg Ala Leu Thr Ala  Arg Val Leu Glu Ala  Ile Gln Arg 
    7415                 7420                 7425             


Trp Leu  Gly Glu Pro Arg Phe  Ala Asp Ser Thr Leu  Val Val Arg 
    7430                 7435                 7440             


Thr Gly  Thr Asp Leu Ala Ser  Ala Ala Val Ser Gly  Leu Val Arg 
    7445                 7450                 7455             


Ser Ala  Gln Ser Glu His Pro  Asp Arg Phe Ile Leu  Val Glu Gly 
    7460                 7465                 7470             


Asp Ser  Ser Pro Val Glu Ile  Gly Leu Asp Glu Pro  Trp Leu Arg 
    7475                 7480                 7485             


Val Asp  Gly Gly Arg Tyr Glu  Val Pro Arg Leu Ile  Arg Leu Ser 
    7490                 7495                 7500             


Ala Glu  Pro Val Gln Glu Ala  Ala Trp Asn Pro Asp  Gly Met Val 
    7505                 7510                 7515             


Leu Ile  Thr Gly Gly Thr Gly  Ala Leu Ala Gly Ile  Leu Ala Arg 
    7520                 7525                 7530             


His Leu  Val Ala Glu Asn Lys  Ala Arg Arg Leu Leu  Leu Val Ser 
    7535                 7540                 7545             


Arg Ser  Val Pro Asp Asp Ala  Leu Ile Ser Glu Leu  Thr Glu Leu 
    7550                 7555                 7560             


Gly Ala  Glu Val Gly Thr Ala  Val Cys Asp Val Ser  Asp Arg Ala 
    7565                 7570                 7575             


Ala Leu  Ala Arg Val Leu Ala  Gly Val Pro Ser Leu  Thr Ala Val 
    7580                 7585                 7590             


Ile His  Thr Ala Gly Val Leu  Asp Asp Gly Val Met  Glu Ser Leu 
    7595                 7600                 7605             


Thr Pro  Gln Arg Leu Asp Thr  Val Leu Arg Ala Lys  Ala Asp Gly 
    7610                 7615                 7620             


Ala Trp  His Leu His Glu Leu  Thr Arg Asp Arg Asp  Leu Ala Ala 
    7625                 7630                 7635             


Phe Val  Met Tyr Ser Ser Ala  Ala Gly Leu Met Gly  Ser Pro Gly 
    7640                 7645                 7650             


Gln Gly  Asn Tyr Ala Ala Ala  Asn Ala Phe Leu Asp  Ala Leu Ala 
    7655                 7660                 7665             


Val Glu  Arg Arg Ala Glu Gly  Leu Pro Ala Leu Ser  Leu Ala Trp 
    7670                 7675                 7680             


Gly Phe  Trp Glu Glu Thr Thr  Gly Leu Thr Ala Asn  Leu Thr Gly 
    7685                 7690                 7695             


Ala Asp  Arg Asp Arg Ile Arg  Arg Gly Gly Leu Gln  Thr Ile Thr 
    7700                 7705                 7710             


Ala Glu  Arg Gly Met Arg Met  Phe Asp Thr Ala Thr  Gln His Gly 
    7715                 7720                 7725             


Glu Pro  Val Leu Leu Ala Ala  Pro Ile Ser Pro Val  Arg Asp Gly 
    7730                 7735                 7740             


Glu Val  Pro Ala Leu Leu Arg  Ser Leu His Arg Arg  Gly Thr Arg 
    7745                 7750                 7755             


Arg Gly  Thr Thr Ala Asp Ala  Ser Ala Gln Trp Leu  Ala Gly Leu 
    7760                 7765                 7770             


Ala Pro  Glu Glu Arg Glu Gly  Ala Leu Ile Lys Val  Val Arg Asp 
    7775                 7780                 7785             


Thr Ala  Ala Val Val Leu Gly  His Ala Asp Ala Gly  Thr Ile Pro 
    7790                 7795                 7800             


Val Thr  Ala Ala Phe Lys Asp  Leu Gly Leu Asp Ser  Leu Thr Ala 
    7805                 7810                 7815             


Val Glu  Leu Arg Asn Ser Leu  Ala Lys Ser Thr Gly  Leu Arg Leu 
    7820                 7825                 7830             


Pro Ala  Thr Met Val Phe Asp  Tyr Pro Thr Pro Ala  Ser Leu Ala 
    7835                 7840                 7845             


Ala Arg  Leu Asp Asp Leu Met  Asn Pro Arg Val Ser  Ser Thr Ala 
    7850                 7855                 7860             


Leu Leu  Ala Glu Leu Asp Arg  Ile Glu Gly Met Phe  Asp Ser Val 
    7865                 7870                 7875             


Thr Phe  Asp Glu Lys Gln Ala  Ser Leu Val Lys Asp  Arg Leu Ser 
    7880                 7885                 7890             


Ala Ala  Leu Gly Lys Trp Gln  Gln Ile Ser Arg Ser  Ala Asp Val 
    7895                 7900                 7905             


Ala Thr  Val Ala Leu Ala Asn  Ala Asp Ala Gly Glu  Ile Leu Asp 
    7910                 7915                 7920             


Phe Ile  Asp Arg Glu Phe Gly  Asn Pro Thr Ile 
    7925                 7930                 


<210>  167
<211>  8134
<212>  PRT
<213>  Streptomyces violaceusniger

<400>  167

Met Pro Asp His Asp Lys Leu Val Glu Tyr Leu Arg Trp Ala Thr Ala 
1               5                   10                  15      


Glu Leu His Thr Thr Arg Ala Lys Leu Gln Ala Ala Thr Glu Ala Gly 
            20                  25                  30          


Thr Gln Pro Leu Ala Ile Val Gly Met Ala Cys Arg Leu Pro Gly Gly 
        35                  40                  45              


Val Ser Ser Pro Glu Asp Leu Trp Arg Leu Val Glu Ser Gly Thr Asp 
    50                  55                  60                  


Ala Ile Ser Gly Phe Pro Val Asp Arg Gly Trp Asp Val Asp Gly Leu 
65                  70                  75                  80  


Tyr Asp Pro Asp Pro Asp Val Pro Gly Lys Ser Tyr Thr Val Glu Gly 
                85                  90                  95      


Gly Phe Leu Asp Ala Val Thr Gly Phe Asp Ala Pro Phe Phe Gly Ile 
            100                 105                 110         


Ser Pro Arg Glu Ala Leu Ala Met Asp Pro Gln Gln Arg Leu Val Leu 
        115                 120                 125             


Glu Ala Ser Trp Glu Ala Phe Glu Arg Ala Gly Ile Glu Pro Gly Ser 
    130                 135                 140                 


Val Arg Gly Ser Asp Thr Gly Val Phe Met Gly Ala Phe Pro Gly Gly 
145                 150                 155                 160 


Tyr Gly Thr Gly Ala Asp Leu Gly Gly Phe Gly Met Thr Gly Gly Ala 
                165                 170                 175     


Ala Ser Val Leu Ser Gly Arg Val Ser Tyr Phe Phe Gly Leu Glu Gly 
            180                 185                 190         


Pro Ala Met Thr Val Asp Thr Val Cys Ser Ser Ser Leu Val Ala Leu 
        195                 200                 205             


His Gln Ala Gly Tyr Ala Leu Arg His Gly Glu Cys Ser Leu Ala Leu 
    210                 215                 220                 


Val Gly Gly Val Thr Val Met Ser Thr Pro Gln Thr Phe Val Glu Phe 
225                 230                 235                 240 


Ser Arg Gln Arg Gly Leu Ala Ala Asp Gly Arg Cys Lys Ala Phe Ala 
                245                 250                 255     


Asp Asn Ala Asp Gly Thr Gly Trp Ser Glu Gly Val Gly Val Leu Leu 
            260                 265                 270         


Val Glu Arg Leu Ser Asp Ala Gln Ala Arg Gly His Asn Ile Leu Ala 
        275                 280                 285             


Val Val Arg Gly Ser Ala Val Asn Gln Asp Gly Ala Ser Asn Gly Leu 
    290                 295                 300                 


Thr Ala Pro Asn Gly Pro Ser Gln Gln Arg Val Ile Arg Gln Ala Leu 
305                 310                 315                 320 


Ala Asn Ala Gly Leu Thr Gly Ala Asp Val Asp Val Val Glu Ala His 
                325                 330                 335     


Gly Thr Gly Thr Thr Leu Gly Asp Pro Ile Glu Ala Gln Ala Val Ile 
            340                 345                 350         


Ala Thr Tyr Gly Arg Asp Arg Asp Gln Pro Val Leu Leu Gly Ser Leu 
        355                 360                 365             


Lys Ser Asn Leu Gly His Thr Gln Ala Ala Ala Gly Val Ser Gly Val 
    370                 375                 380                 


Ile Lys Met Val Met Ala Leu Gln Asn Gly Val Val Pro Arg Thr Leu 
385                 390                 395                 400 


His Ile Glu Glu Pro Ser Arg His Val Asp Trp Thr Ala Gly Ala Val 
                405                 410                 415     


Gln Leu Val Thr Glu Asn Arg Pro Trp Pro Glu Leu Gly Arg Ala Arg 
            420                 425                 430         


Arg Ala Ala Val Ser Ser Phe Gly Leu Ser Gly Thr Asn Ala His Val 
        435                 440                 445             


Ile Leu Glu Ser Ala Pro Asp Gln Pro Pro Ala Pro Thr Thr Asp Thr 
    450                 455                 460                 


Pro Val Ser Ala Val Thr Ala Gly Val Val Pro Leu Pro Ile Ser Ala 
465                 470                 475                 480 


Lys Thr Val Pro Ala Leu Ala Asp Leu Glu Asp Arg Leu Arg Thr Tyr 
                485                 490                 495     


Leu Thr Thr Thr Pro Asp Thr Asp Leu Pro Ala Val Ala Ser Thr Leu 
            500                 505                 510         


Ala Thr Thr Arg Ser Leu Phe Glu His Arg Ala Val Leu Leu Gly Glu 
        515                 520                 525             


Asp Thr Val Thr Gly Thr Ala Ile Pro Asp Pro Arg Val Val Phe Val 
    530                 535                 540                 


Phe Pro Gly Gln Gly Trp Gln Trp Gln Gly Met Gly Ser Ala Leu Leu 
545                 550                 555                 560 


Thr Ser Ser Thr Val Phe Ala Glu Arg Met Ala Glu Cys Ala Ala Ala 
                565                 570                 575     


Leu Ser Glu Phe Val Asp Trp Asp Leu Leu Thr Val Leu Asp Asp Pro 
            580                 585                 590         


Ser Val Val Asp Arg Val Asp Val Val Gln Pro Ala Cys Trp Ala Val 
        595                 600                 605             


Met Ile Ser Leu Ala Ala Val Trp Gln Ala Ala Gly Ile His Pro Asp 
    610                 615                 620                 


Ile Val Leu Gly His Ser Gln Gly Glu Ile Ala Ala Ala Cys Leu Ala 
625                 630                 635                 640 


Gly Ala Ile Ser Leu Pro Asp Ala Ala Arg Ile Val Ala Gln Arg Ser 
                645                 650                 655     


Gln Leu Ile Ala His Gln Leu Thr Gly His Gly Ala Met Ala Ser Ile 
            660                 665                 670         


Ser Leu Pro Ala Asp Asp Ile Pro Thr Thr Asp Lys Val Trp Ile Ala 
        675                 680                 685             


Ala His Asn Gly Thr Ser Thr Val Ile Ala Gly Asp Pro Gln Ala Val 
    690                 695                 700                 


Glu Ala Val Leu Ala Thr Cys Glu Thr Arg Gly Ala Arg Val Arg Lys 
705                 710                 715                 720 


Ile Asn Val Asp Tyr Ala Ser His Thr Pro His Val Glu Gln Ile Arg 
                725                 730                 735     


Thr Glu Leu Leu Asp Ile Thr Thr Gly Ile Glu Ala His Thr Pro Ala 
            740                 745                 750         


Val Pro Trp Leu Ser Thr Thr Asp Asn Thr Trp Ile Asp Gln Pro Leu 
        755                 760                 765             


Asp Pro Thr Tyr Trp Tyr Arg Asn Leu Arg Glu Pro Val Arg Phe Gly 
    770                 775                 780                 


Pro Ala Ile Asp Leu Leu Gln Thr Gln Asp Asn Asn Leu Phe Ile Glu 
785                 790                 795                 800 


Ile Ser Ala Ser Pro Val Leu Leu Gln Thr Met Asp Asn Ala Ala Thr 
                805                 810                 815     


Val Ala Thr Leu Arg Arg Asp Glu Asp Thr Thr Gln Arg Leu Leu Thr 
            820                 825                 830         


Ala Phe Ala Glu Ala His Val His Gly Ala Thr Ile Asp Trp Pro Thr 
        835                 840                 845             


Val Leu Asp Thr Thr Thr Thr Pro Val Leu Asp Leu Pro Thr Tyr Pro 
    850                 855                 860                 


Phe Gln Arg Gln Arg Tyr Trp Ala Thr Ser Asn Gly Arg Ser Thr Gly 
865                 870                 875                 880 


Gln Gly His Pro Leu Leu Glu Thr Val Val Ala Leu Pro Gly Thr Asp 
                885                 890                 895     


Gly Val Ala Leu Thr Gly Arg Ile Ser Leu Ala Thr His Pro Trp Leu 
            900                 905                 910         


Thr Asp His Thr Val Arg Gly Thr Val Leu Leu Pro Gly Thr Ala Phe 
        915                 920                 925             


Val Glu Leu Val Thr Arg Ala Ala Thr Glu Val Asn Cys Gln Ile Ile 
    930                 935                 940                 


Asp Glu Leu Ile Ile Glu Ala Pro Leu Pro Leu Pro Gln Thr Asp Gly 
945                 950                 955                 960 


Val Gln Leu Ser Val Thr Val Gly Glu Ala Asp Glu Ala Gly His Arg 
                965                 970                 975     


Pro Val Thr Val Tyr Ser Gln Thr Asp Glu Ser Asp Asp Trp Ile Gln 
            980                 985                 990         


His Val Thr Ala Thr Ile Gly Pro  Gly Ala Ser Leu Pro  Glu Thr Ala 
        995                 1000                 1005             


Ala Trp  Pro Pro Ala His Ala  Glu Pro Val Asn Val  Thr Gly Leu 
    1010                 1015                 1020             


Tyr Asp  Asn Leu Ala Ala Ala  Gly Tyr Glu Tyr Gly  Pro Ala Phe 
    1025                 1030                 1035             


Gln Gly  Leu Gln Ala Ala Trp  Arg Ala Gly Asp Thr  Val Tyr Ala 
    1040                 1045                 1050             


Glu Val  Thr Leu Ala Glu Glu  Gln Ala Gln Glu Thr  Ala Arg Phe 
    1055                 1060                 1065             


Thr Met  His Pro Ala Leu Leu  Asp Ala Ala Leu His  Thr Ile Ala 
    1070                 1075                 1080             


Leu His  Asp Thr Gly Asp Leu  His Leu Pro Phe Ser  Trp Thr Arg 
    1085                 1090                 1095             


Val Gln  Phe His Gly Thr Gly  Ala Ala Thr Leu Arg  Val Ala Val 
    1100                 1105                 1110             


Thr Pro  Ala Ala Asp Gly Trp  Asn Ile Arg Ala Thr  Asp Asp Thr 
    1115                 1120                 1125             


Gly Arg  Ala Val Ala Thr Ile  Gly Ser Leu Val Thr  Arg Pro Met 
    1130                 1135                 1140             


Ala Ala  Glu Thr Thr Asp Asp  Leu Leu Ala Leu Thr  Trp Thr Glu 
    1145                 1150                 1155             


Ile Pro  Ala Pro Glu Pro Val  Asp Pro Thr Asp Val  Val Val Phe 
    1160                 1165                 1170             


Thr Ala  Leu Pro Asp Thr Val  Glu Asp Val Pro Ala  Gln Thr Arg 
    1175                 1180                 1185             


Ala Leu  Thr Thr Arg Val Leu  His Thr Ile Gln Glu  Trp Leu Ala 
    1190                 1195                 1200             


Asp Asp  Asp Arg Thr Leu Ile  Val Arg Thr Gly Thr  Asp Leu Ala 
    1205                 1210                 1215             


Ser Ala  Ala Val Ser Gly Leu  Val Arg Ser Ala Gln  Ser Glu His 
    1220                 1225                 1230             


Pro Gly  Arg Phe Ile Leu Val  Glu Ser Ala Asp Glu  Ala Leu Thr 
    1235                 1240                 1245             


Gln Glu  Gln Leu Ala Ala Thr  Ala Gly Leu Asp Glu  Pro Arg Leu 
    1250                 1255                 1260             


Arg Ile  Thr Gly Gly Arg Tyr  Glu Val Pro Arg Leu  Thr Arg Glu 
    1265                 1270                 1275             


Asp Thr  Ala Leu Ala Val Pro  Thr Asp Arg Ala Trp  Leu Leu Glu 
    1280                 1285                 1290             


Gln Pro  Arg Ser Gly Ser Leu  Glu Asp Leu Ala Leu  Leu Pro Thr 
    1295                 1300                 1305             


Asp Ala  Ala Glu Arg Pro Leu  Gln Ala Gly Glu Val  Arg Ile Gly 
    1310                 1315                 1320             


Val Arg  Ala Ala Gly Met Asn  Phe Arg Asp Val Val  Val Ala Leu 
    1325                 1330                 1335             


Gly Met  Val Thr Asp Thr Arg  Leu Ala Gly Gly Glu  Ala Ala Gly 
    1340                 1345                 1350             


Val Val  Leu Glu Val Gly Thr  Asp Val Asn Asp Phe  Arg Pro Gly 
    1355                 1360                 1365             


Asp Arg  Val Phe Gly Ile Leu  Glu Gly Gly Phe Gly  Ser Val Ala 
    1370                 1375                 1380             


Ile Cys  Asp His Arg Thr Leu  Ala Val Ile Pro Asp  Gly Trp Ser 
    1385                 1390                 1395             


Phe Thr  Thr Ala Ala Ser Val  Pro Ile Ala Phe Ala  Thr Ala Tyr 
    1400                 1405                 1410             


Tyr Gly  Leu Val Asp Leu Ala  Gly Leu Arg Ala Gly  Glu Ser Val 
    1415                 1420                 1425             


Leu Ile  His Ala Ala Thr Gly  Gly Val Gly Ile Ala  Ala Thr Gln 
    1430                 1435                 1440             


Ile Ala  Arg His Leu Gly Ala  Glu Ile Tyr Gly Thr  Ala Ser Val 
    1445                 1450                 1455             


Gly Lys  Gln His Val Leu Arg  Asp Ala Gly Leu Ala  Asp Asp Arg 
    1460                 1465                 1470             


Ile Ala  Asp Ser Arg Thr Thr  Asp Phe Arg Asp Thr  Phe Arg Asp 
    1475                 1480                 1485             


Gly Thr  Gln Gly Arg Gly Val  Asp Val Val Leu Asn  Ser Leu Arg 
    1490                 1495                 1500             


Gly Glu  Phe Ile Asp Ala Ser  Leu Asp Leu Leu Val  Asp Gly Gly 
    1505                 1510                 1515             


Arg Phe  Ile Glu Met Gly Lys  Thr Asp Ile Arg Asp  Ala Ala Gln 
    1520                 1525                 1530             


Ile Pro  Asp Ala Thr Tyr His  Ala Phe Asp Leu Met  Asp Ala Gly 
    1535                 1540                 1545             


His Asp  Arg Leu Arg Glu Ile  Met Thr Glu Leu Leu  Ala Leu Phe 
    1550                 1555                 1560             


Glu Gln  Gly Val Leu His Pro  Met Pro Val His Ala  Phe Asp Ile 
    1565                 1570                 1575             


Arg Gln  Ala Arg Glu Ala Phe  Ser Trp Met Ser Arg  Ala Arg His 
    1580                 1585                 1590             


Ile Gly  Lys Leu Val Leu Thr  Ile Pro Gln Pro Ile  Asp Pro Asp 
    1595                 1600                 1605             


Gly Thr  Val Leu Ile Thr Gly  Gly Ser Gly Val Leu  Ala Gly Ile 
    1610                 1615                 1620             


Val Ala  Arg Tyr Leu Val Thr  Glu Asn Arg Ala Arg  His Leu Leu 
    1625                 1630                 1635             


Leu Leu  Ser Arg Ser Ala Pro  Ser Ala Ser Leu Ile  Asp Glu Leu 
    1640                 1645                 1650             


Thr Ala  Leu Gly Ala His Val  Asp Val Ala Ala Cys  Asp Val Ala 
    1655                 1660                 1665             


Asp Arg  Ala Ala Leu Ala Glu  Ile Leu Asp Gly Val  Asp Leu Thr 
    1670                 1675                 1680             


Ala Val  Ile His Thr Ala Gly  Ala Leu Asp Asp Gly  Val Val Glu 
    1685                 1690                 1695             


Ser Leu  Thr Pro Gln Arg Leu  Asp Thr Val Leu Thr  Pro Lys Ala 
    1700                 1705                 1710             


Asp Gly  Ala Trp His Leu His  Glu Leu Thr Arg Asp  Arg Asp Leu 
    1715                 1720                 1725             


Ala Ala  Phe Ile Val Tyr Ser  Ser Ala Ala Gly Val  Leu Gly Ala 
    1730                 1735                 1740             


Ala Gly  Gln Gly Asn Tyr Ala  Ala Ala Asn Ala Phe  Leu Asp Ala 
    1745                 1750                 1755             


Leu Ala  Val His Arg Arg Leu  Glu Gly Leu Pro Gly  Leu Ser Leu 
    1760                 1765                 1770             


Ala Trp  Gly Leu Trp Glu Asp  Ala Ser Gly Leu Thr  Ala Asp Leu 
    1775                 1780                 1785             


Thr Asp  Ala Asp Arg Asp Arg  Ile Arg Arg Ser Gly  Gln Arg Ala 
    1790                 1795                 1800             


Ile Thr  Ala Ala Tyr Gly Met  Arg Met Leu Asp Ala  Ala Thr Arg 
    1805                 1810                 1815             


Gln Ser  Glu Ala Ile Leu Leu  Ala Ala Pro Ile Ser  Pro Ile Gln 
    1820                 1825                 1830             


Asp Gly  Asp Val Pro Ala Ile  Leu Arg Ser Leu His  Arg Arg Val 
    1835                 1840                 1845             


Gly Arg  Arg Ala Ser Val Ala  His Gly His Pro Ala  Asp Leu Thr 
    1850                 1855                 1860             


Pro Glu  Ala Leu Leu Lys Val  Val Arg Asp Ser Ala  Ala Met Val 
    1865                 1870                 1875             


Leu Gly  His Thr Asn Ala Asp  Thr Val Pro Thr Ala  Thr Ala Phe 
    1880                 1885                 1890             


Gln Glu  Leu Gly Leu Asp Ser  Leu Thr Ala Val Glu  Leu Arg Asn 
    1895                 1900                 1905             


Ser Leu  Thr Lys Ala Thr Gly  Leu Arg Leu Pro Ala  Thr Met Ala 
    1910                 1915                 1920             


Phe Asp  Tyr Pro Thr Pro Asp  Ala Leu Ala Ala Arg  Leu Gly Glu 
    1925                 1930                 1935             


Leu Leu  Ala Gly Glu Ala Ala  Pro Lys Ala Ala Ala  Ala Val Arg 
    1940                 1945                 1950             


Arg Ala  Thr Ala Ser Asp Glu  Pro Leu Ala Ile Val  Gly Met Ala 
    1955                 1960                 1965             


Cys Arg  Leu Pro Gly Gly Val  Ser Ser Pro Glu Asp  Leu Trp Arg 
    1970                 1975                 1980             


Leu Val  Glu Ser Gly Thr Asp  Ala Ile Thr Asp Phe  Pro Thr Asp 
    1985                 1990                 1995             


Arg Gly  Trp Asp Thr Asp Thr  Leu Phe Asp Pro Asp  Pro Asp Thr 
    2000                 2005                 2010             


Pro Gly  Lys Thr Tyr Thr Val  His Gly Gly Phe Leu  Asn Asp Val 
    2015                 2020                 2025             


Ala Gly  Phe Asp Ala Pro Phe  Phe Gly Ile Ser Pro  Arg Glu Ala 
    2030                 2035                 2040             


Val Ala  Met Asp Pro Gln Gln  Arg Leu Val Leu Glu  Ser Ser Trp 
    2045                 2050                 2055             


Glu Ala  Phe Glu Arg Ala Gly  Ile Gln Pro Asp Ser  Ile Arg Gly 
    2060                 2065                 2070             


Ser Asp  Thr Gly Val Phe Met  Gly Ala Tyr Pro Asp  Gly Tyr Gly 
    2075                 2080                 2085             


Ile Gly  Ala Asp Leu Ala Gly  Phe Gly Val Thr Ala  Gly Ala Gly 
    2090                 2095                 2100             


Ser Val  Leu Ser Gly Arg Val  Ser Tyr Phe Phe Gly  Leu Glu Gly 
    2105                 2110                 2115             


Pro Ala  Met Thr Val Asp Thr  Ala Cys Ser Ser Ser  Leu Val Ala 
    2120                 2125                 2130             


Leu His  Gln Ala Ala Tyr Ala  Leu Arg Gln Gly Glu  Cys Ser Leu 
    2135                 2140                 2145             


Ala Leu  Val Gly Gly Val Thr  Val Met Pro Ser Pro  Arg Thr Phe 
    2150                 2155                 2160             


Ile Glu  Phe Ser Arg Gln Arg  Gly Leu Ala Ala Asp  Gly Arg Ser 
    2165                 2170                 2175             


Lys Ala  Phe Ala Asp Ala Ala  Asp Gly Thr Gly Phe  Ser Glu Gly 
    2180                 2185                 2190             


Val Gly  Val Leu Leu Val Glu  Arg Leu Ser Asp Ala  Gln Ala Lys 
    2195                 2200                 2205             


Gly His  Asn Ile Leu Ala Leu  Val Arg Ser Ser Ala  Val Asn Gln 
    2210                 2215                 2220             


Asp Gly  Ala Ser Asn Gly Leu  Thr Ala Pro Asn Gly  Pro Ser Gln 
    2225                 2230                 2235             


Gln Arg  Val Ile Gln Ser Ala  Leu Ala Gly Ala Gly  Leu Thr Ser 
    2240                 2245                 2250             


Ala Asp  Val Asp Val Val Glu  Ala His Gly Thr Gly  Thr Thr Leu 
    2255                 2260                 2265             


Gly Asp  Pro Ile Glu Ala Gln  Ala Val Leu Ala Thr  Tyr Gly Gln 
    2270                 2275                 2280             


Asp Arg  Asp Gln Pro Val Leu  Leu Gly Ser Leu Lys  Ser Asn Leu 
    2285                 2290                 2295             


Gly His  Thr Gln Ala Ala Ala  Gly Val Ser Gly Val  Ile Lys Met 
    2300                 2305                 2310             


Val Met  Ala Leu Gln His Asn  Thr Val Pro Ala Thr  Leu His Val 
    2315                 2320                 2325             


Asp Ala  Pro Ser Arg His Val  Asp Trp Thr Ala Gly  Ala Val Arg 
    2330                 2335                 2340             


Leu Ala  Thr Glu Asn Gln Pro  Trp Pro Glu Thr Asn  Arg Pro Arg 
    2345                 2350                 2355             


Arg Ala  Gly Val Ser Ser Phe  Gly Val Ser Gly Thr  Asn Ala His 
    2360                 2365                 2370             


Val Ile  Leu Glu Gln Ala Pro  Ala Ala Ser Pro Val  Glu Pro Val 
    2375                 2380                 2385             


Asp Thr  Thr Asp Val Val Ile  Pro Leu Val Val Ser  Ala Arg Ser 
    2390                 2395                 2400             


Ser Gly  Ser Leu Ser Asp Gln  Ala Asp Arg Leu Ala  Ala Leu Val 
    2405                 2410                 2415             


Gly Ser  Pro Asp Ala Pro Ala  Leu Thr Ser Leu Ala  Asp Ala Leu 
    2420                 2425                 2430             


Leu Thr  Arg Arg Thr Val Phe  Ser Gln Arg Ala Val  Val Val Ala 
    2435                 2440                 2445             


Gly Ser  His Glu Gln Ala Ala  Ala Gly Leu Arg Ala  Leu Ala Ser 
    2450                 2455                 2460             


Gly Asp  Ser His Pro Ala Leu  Val Thr Gly Ala Ala  Gly Pro Ala 
    2465                 2470                 2475             


Arg Gly  Val Val Leu Val Phe  Pro Gly Gln Gly Ser  Gln Trp Ala 
    2480                 2485                 2490             


Gly Met  Gly Ala Glu Leu Leu  Asp Thr Ser Pro Val  Phe Ala Ala 
    2495                 2500                 2505             


Arg Ile  Ala Glu Cys Ala Glu  Ala Leu Arg Pro Trp  Val Asp Trp 
    2510                 2515                 2520             


Ser Leu  Asp Glu Val Leu Arg  Gly Asp Ala Ser Ala  Asp Val Leu 
    2525                 2530                 2535             


Gly Arg  Val Asp Val Val Gln  Pro Ala Ser Phe Ala  Val Met Val 
    2540                 2545                 2550             


Gly Leu  Ala Ala Val Trp Glu  Ser Ala Gly Val Arg  Pro Asp Ala 
    2555                 2560                 2565             


Val Leu  Gly His Ser Gln Gly  Glu Ile Ala Ala Ala  Tyr Val Ala 
    2570                 2575                 2580             


Gly Ala  Leu Ser Leu Thr Asp  Ala Ala Lys Ile Val  Ala Val Arg 
    2585                 2590                 2595             


Ser Arg  Leu Ile Ala Ala Arg  Leu Ala Gly Arg Gly  Gly Met Ala 
    2600                 2605                 2610             


Ser Val  Ala Leu Ala Pro Asp  Glu Ala Ala Ala Lys  Leu Gly Arg 
    2615                 2620                 2625             


Thr Glu  Leu Ala Ala Val Asn  Gly Pro Ala Ser Val  Val Ile Ala 
    2630                 2635                 2640             


Gly Asp  Ala Glu Ala Leu Asp  Glu Thr Leu Ala Met  Leu Glu Gly 
    2645                 2650                 2655             


Glu Ala  Val Arg Val Arg Arg  Val Ala Val Asp Tyr  Ala Ser His 
    2660                 2665                 2670             


Thr Pro  His Val Glu Glu Leu  Glu Gln Ser Met Ala  Glu Ala Leu 
    2675                 2680                 2685             


Ala Asp  Val Arg Ser Arg Gln  Pro Arg Val Gly Phe  Leu Ser Thr 
    2690                 2695                 2700             


Val Thr  Gly Asp Trp Val Thr  Glu Ala Gly Ala Leu  Asp Gly Gly 
    2705                 2710                 2715             


Tyr Trp  Tyr Arg Asn Leu Arg  Gln Pro Val Arg Phe  Gly Pro Ala 
    2720                 2725                 2730             


Val Ala  Ser Leu Ala Glu Ala  Gly Tyr Thr Val Phe  Val Glu Ala 
    2735                 2740                 2745             


Ser Ala  His Pro Val Leu Val  Gln Pro Val Ala Glu  Thr Leu Asp 
    2750                 2755                 2760             


Arg Thr  Asp Ala Val Val Thr  Gly Thr Leu Arg Arg  Gln Asp Gly 
    2765                 2770                 2775             


Gly Leu  Pro Arg Leu Leu Thr  Ser Met Ala Glu Leu  Phe Val Gly 
    2780                 2785                 2790             


Gly Val  Pro Val Asn Trp Pro  Val Leu Leu Pro Ala  Gly Ala Val 
    2795                 2800                 2805             


Arg Gly  Trp Val Asp Leu Pro  Thr Tyr Ala Phe Asp  His Gln Arg 
    2810                 2815                 2820             


Tyr Trp  Leu Glu Asn Arg Val  Ala Thr Asp Ala Ala  Ala Leu Gly 
    2825                 2830                 2835             


Leu Ala  Gly Ala Asp His Pro  Leu Leu Gly Ala Ile  Val Ala Val 
    2840                 2845                 2850             


Pro Gln  Ser Gly Gly Val Ala  Met Thr Ser Arg Leu  Ser Pro Arg 
    2855                 2860                 2865             


Asn His  Pro Trp Leu Ala Glu  His Thr Leu Gly Gly  Val Pro Thr 
    2870                 2875                 2880             


Val Pro  Thr Ser Val Leu Val  Glu Leu Ala Val Arg  Ala Gly Asp 
    2885                 2890                 2895             


Glu Val  Gly Cys Gly Val Val  Glu Glu Leu Thr Val  Asp Ala Pro 
    2900                 2905                 2910             


Leu Leu  Leu Pro Glu Arg Gly  Gly Val Arg Val Gln  Val Ile Val 
    2915                 2920                 2925             


Gly Ala  Thr Asp Ala Asn Gly  Gln Arg Gly Leu Asp  Ile Phe Ser 
    2930                 2935                 2940             


Ala Pro  Glu Asp Thr Gly Gln  Glu Ala Trp Thr Arg  His Ala Thr 
    2945                 2950                 2955             


Gly Thr  Leu Ala Pro Gly Gly  Asp Ile Ala Ala Asp  Val Asp Leu 
    2960                 2965                 2970             


Ser Ala  Trp Pro Pro Ala Asn  Ala Gln Pro Val Asp  Val Thr Asp 
    2975                 2980                 2985             


Gly Tyr  Asp Leu Leu Glu Arg  Ala Gly Tyr Gly Tyr  Gly Pro Ala 
    2990                 2995                 3000             


Phe Gln  Gly Val Arg Ala Ile  Trp Arg Arg Gly Glu  Glu Leu Phe 
    3005                 3010                 3015             


Ala Glu  Val Ala Leu Glu Pro  Glu Leu Thr Asp Thr  Ala Ala Arg 
    3020                 3025                 3030             


Phe Gly  Leu His Pro Ala Leu  Leu Asp Ala Ala Trp  His Pro Glu 
    3035                 3040                 3045             


Leu Arg  Asp Glu Val Ala Glu  Thr Ser Pro Asp Gly  Arg Arg Trp 
    3050                 3055                 3060             


Trp Ser  Gln Pro Ser Arg Trp  Ala Gly Leu Arg Leu  His Thr Ala 
    3065                 3070                 3075             


Gly Ala  Thr Val Leu Arg Val  Arg Leu Ala Pro Val  Asp Ala Asp 
    3080                 3085                 3090             


Ser Met  Ser Leu Gln Ala Ala  Asp Glu Thr Gly Asp  Pro Val Leu 
    3095                 3100                 3105             


Thr Val  Asp Ser Leu Ser Leu  Cys Ala Val Ser Ala  Asp Gln Leu 
    3110                 3115                 3120             


Thr Thr  Ala Glu Ser Ser Asp  Asp Ala Leu Phe Arg  Leu Glu Trp 
    3125                 3130                 3135             


Thr Pro  Leu Ser Lys Ala Pro  Thr Ala Ala Arg Ser  Trp Val Pro 
    3140                 3145                 3150             


Val Glu  Thr Gly Ala Asp Val  Ala Ala Leu Asp Gly  Gln Ala Val 
    3155                 3160                 3165             


Val Asp  Ala Val Met Leu Glu  Ala Ala Gly Thr Gly  Asp Ala Leu 
    3170                 3175                 3180             


Glu Leu  Thr Cys Arg Val Leu  Glu Val Val Gln Ala  Trp Leu Thr 
    3185                 3190                 3195             


Leu Pro  Gly Trp Asp Glu Ser  Arg Leu Val Val Val  Thr Arg Gly 
    3200                 3205                 3210             


Ala Val  Gly Ala Val Gly Asp  Pro Ala Gly Ser Ala  Val Trp Gly 
    3215                 3220                 3225             


Leu Val  Arg Ala Ala Gln Ala  Glu Asn Pro Asp Arg  Ile Ala Leu 
    3230                 3235                 3240             


Leu Asp  Leu Asp Gly Gly Arg  Pro Val Glu Pro Leu  Leu Ala Glu 
    3245                 3250                 3255             


Ser Glu  Pro Gln Leu Ala Ile  Arg Gly Ala Glu Ala  Leu Val Pro 
    3260                 3265                 3270             


Arg Leu  Ile Arg Ala Ala Ala  Ala Thr Asp Ala Pro  Ala Leu Phe 
    3275                 3280                 3285             


Asp Glu  Ser Gln Thr Val Leu  Ile Thr Gly Gly Thr  Gly Ser Leu 
    3290                 3295                 3300             


Gly Gly  Leu Leu Ala Arg His  Leu Val Gly Arg Tyr  Gly Leu Arg 
    3305                 3310                 3315             


Arg Leu  Val Leu Val Ser Arg  Arg Gly Pro Asp Ala  Pro Gly Ala 
    3320                 3325                 3330             


Tyr Glu  Leu Ala Ala Glu Leu  Ala Ala His Gly Ala  Glu Ala Ala 
    3335                 3340                 3345             


Leu Val  Ala Cys Asp Leu Thr  Asp Arg Asp Ala Val  Ala Arg Leu 
    3350                 3355                 3360             


Leu Thr  Glu His His Pro Thr  Ala Val Val His Ala  Ala Gly Val 
    3365                 3370                 3375             


Ser Asp  Asp Gly Val Ile Gly  Thr Leu Thr Ser Asp  Arg Leu Ala 
    3380                 3385                 3390             


Tyr Val  Phe Gly Pro Lys Ala  Thr Ala Ala Arg His  Leu Asp Glu 
    3395                 3400                 3405             


Leu Thr  Arg Glu Leu Leu Pro  Asp Leu Ala Ala Phe  Val Thr Tyr 
    3410                 3415                 3420             


Ser Ser  Ile Ser Ala Val Phe  Leu Gly Ala Gly Ser  Gly Gly Tyr 
    3425                 3430                 3435             


Ala Ala  Ala Asn Ala Tyr Leu  Asp Gly Leu Met Ala  Arg Arg His 
    3440                 3445                 3450             


Ala Glu  Gly Leu Pro Gly Leu  Ser Leu Ala Trp Gly  Leu Trp Asp 
    3455                 3460                 3465             


Gln Glu  Ala Asp Gly Gly Gly  Met Ala Ala Gly Leu  Gln Asp Ile 
    3470                 3475                 3480             


Thr Arg  Asn Arg Met Arg Arg  Arg Gly Gly Val Leu  Ser Phe Thr 
    3485                 3490                 3495             


Pro Ala  Glu Gly Met Ala Leu  Phe Asp Ala Ala Met  Ala Thr Asp 
    3500                 3505                 3510             


Glu Ala  Leu Val Val Pro Val  Arg Leu Asp Leu Pro  Ala Leu Arg 
    3515                 3520                 3525             


Ala Glu  Ala Val Ala Glu Gly  Arg Ser Ala Pro Val  Leu Leu Arg 
    3530                 3535                 3540             


Gly Leu  Val Arg Pro Gly Arg  Arg Leu Ala Arg Thr  Val Ser Gly 
    3545                 3550                 3555             


Gly Thr  Gly Val Leu Ala Asp  Leu Thr Pro Glu Ala  Leu Leu Lys 
    3560                 3565                 3570             


Leu Val  Arg Gly Arg Ala Ala  Ala Val Leu Gly His  Val Asp Ala 
    3575                 3580                 3585             


Asp Ala  Val Pro Val Ala Ala  Ala Phe Lys Asp Leu  Gly Val Asp 
    3590                 3595                 3600             


Ser Leu  Thr Ala Val Glu Leu  Arg Asn Ser Leu Ala  Lys Ala Thr 
    3605                 3610                 3615             


Gly Leu  Arg Leu Pro Ala Thr  Leu Val Phe Asp Tyr  Pro Thr Pro 
    3620                 3625                 3630             


Thr Val  Leu Ala Gly Arg Leu  Gly Glu Leu Leu Ala  Gly Gly Thr 
    3635                 3640                 3645             


Ala Pro  Val Arg Ala Ala Val  Val Arg Arg Ala Ala  Ala Ser Asp 
    3650                 3655                 3660             


Glu Pro  Leu Ala Ile Val Gly  Met Ala Cys Arg Leu  Pro Gly Gly 
    3665                 3670                 3675             


Val Leu  Ser Pro Glu Asp Leu  Trp Arg Leu Val Glu  Ser Gly Gly 
    3680                 3685                 3690             


Asp Ala  Ile Ser Gly Phe Pro  Val Asp Arg Gly Trp  Asp Val Glu 
    3695                 3700                 3705             


Asn Leu  Phe Asp Pro Asp Pro  Asp Ala Ala Gly Arg  Thr Tyr Ala 
    3710                 3715                 3720             


Val Arg  Gly Gly Phe Leu Asp  Gly Ala Ala Gly Phe  Asp Ala Ser 
    3725                 3730                 3735             


Phe Phe  Gly Ile Ser Pro Arg  Glu Ala Gln Ala Met  Asp Pro Gln 
    3740                 3745                 3750             


Gln Arg  Leu Val Leu Glu Val  Ser Trp Glu Ala Phe  Glu Arg Ala 
    3755                 3760                 3765             


Gly Ile  Glu Pro Gly Ser Val  Arg Gly Ser Asp Thr  Gly Val Phe 
    3770                 3775                 3780             


Met Gly  Ala Tyr Pro Gly Gly  Tyr Gly Met Gly Thr  Asp Leu Gly 
    3785                 3790                 3795             


Gly Phe  Gly Met Thr Ser Val  Ala Val Ser Val Leu  Ala Gly Arg 
    3800                 3805                 3810             


Val Ser  Tyr Phe Phe Gly Leu  Glu Gly Pro Ala Met  Thr Val Asp 
    3815                 3820                 3825             


Thr Ala  Cys Ser Ser Ser Leu  Val Ala Leu His Gln  Ala Gly Ser 
    3830                 3835                 3840             


Ala Leu  Arg Gln Gly Glu Cys  Ser Leu Ala Leu Val  Gly Gly Val 
    3845                 3850                 3855             


Thr Val  Met Pro Thr Pro Gln  Thr Phe Val Glu Phe  Ser Arg Gln 
    3860                 3865                 3870             


Arg Gly  Leu Ala Ala Asp Gly  Arg Cys Lys Ala Phe  Ala Asp Ala 
    3875                 3880                 3885             


Ala Asp  Gly Thr Gly Phe Ser  Glu Gly Val Gly Val  Leu Leu Val 
    3890                 3895                 3900             


Glu Arg  Leu Ser Asp Ala Gln  Ala Arg Gly His Asn  Ile Leu Ala 
    3905                 3910                 3915             


Val Val  Arg Gly Ser Ala Val  Asn Gln Asp Gly Ala  Ser Asn Gly 
    3920                 3925                 3930             


Leu Thr  Ala Pro Asn Gly Pro  Ala Gln Gln Arg Val  Ile Gln Ser 
    3935                 3940                 3945             


Ala Leu  Ala Gly Ala Gly Leu  Ala Ser Ala Asp Val  Asp Val Val 
    3950                 3955                 3960             


Glu Ala  His Gly Thr Gly Thr  Thr Leu Gly Asp Pro  Ile Glu Ala 
    3965                 3970                 3975             


Gln Ala  Val Ile Ala Thr Tyr  Gly Gln Asp Arg Asp  Gln Pro Val 
    3980                 3985                 3990             


Leu Leu  Gly Ser Leu Lys Ser  Asn Leu Gly His Thr  Gln Ala Ala 
    3995                 4000                 4005             


Ala Gly  Val Ser Gly Val Ile  Lys Met Val Met Ala  Leu Gln Asn 
    4010                 4015                 4020             


Gly Val  Val Pro Arg Thr Leu  His Ile Asp Glu Pro  Ser Arg His 
    4025                 4030                 4035             


Ile Asp  Trp Thr Ala Gly Ala  Val Glu Leu Val Thr  Glu Asn Gln 
    4040                 4045                 4050             


Ser Trp  Pro Glu Thr Gly Arg  Ala Arg Arg Ala Ala  Val Ser Ser 
    4055                 4060                 4065             


Phe Gly  Ile Ser Gly Thr Asn  Ala His Val Ile Leu  Glu Ser Ala 
    4070                 4075                 4080             


Pro Ala  Gln Pro Val Pro Leu  Val Asp Thr Pro Val  Ser Asp Val 
    4085                 4090                 4095             


Thr Ala  Gly Val Val Pro Leu  Pro Ile Ser Ala Arg  Thr Val Pro 
    4100                 4105                 4110             


Ala Leu  Ala Asp Leu Glu Asp  Gln Leu Arg Ala Tyr  Leu Thr Thr 
    4115                 4120                 4125             


Ala Pro  Glu Thr Asp Leu Pro  Ala Val Ala Ser Thr  Leu Ala Met 
    4130                 4135                 4140             


Thr Arg  Ser Val Phe Glu His  Arg Ala Val Leu Leu  Gly Glu Glu 
    4145                 4150                 4155             


Thr Val  Thr Gly Ile Ala Val  Ser Asp Pro Arg Val  Val Phe Val 
    4160                 4165                 4170             


Phe Ser  Gly Gln Gly Ser Gln  Arg Val Gly Met Gly  Glu Glu Leu 
    4175                 4180                 4185             


Ala Ala  Ala Phe Pro Leu Phe  Ala Arg Leu His Arg  Gln Val Trp 
    4190                 4195                 4200             


Asp Leu  Leu Asp Val Pro Asp  Leu Glu Val Asp Asp  Thr Gly Tyr 
    4205                 4210                 4215             


Val Gln  Pro Ala Leu Phe Ala  Leu Gln Val Ala Leu  Phe Gly Leu 
    4220                 4225                 4230             


Leu Glu  Ser Trp Gly Val Arg  Pro Arg Ala Val Ile  Gly His Ser 
    4235                 4240                 4245             


Val Gly  Glu Val Ala Ala Gly  Tyr Val Ala Gly Val  Trp Ser Leu 
    4250                 4255                 4260             


Glu Asp  Ala Cys Thr Leu Val  Ser Ala Arg Ala Arg  Leu Met Gln 
    4265                 4270                 4275             


Ala Leu  Pro Ala Gly Gly Ala  Met Val Ala Val Pro  Val Ser Glu 
    4280                 4285                 4290             


Glu Arg  Ala Arg Ala Val Leu  Val Asp Gly Val Glu  Ile Ala Ala 
    4295                 4300                 4305             


Val Asn  Gly Pro Ala Ser Val  Val Leu Ser Gly Asp  Glu Ser Ala 
    4310                 4315                 4320             


Val Leu  Arg Val Ala Glu Gly  Leu Gly Arg Trp Thr  Arg Leu Ser 
    4325                 4330                 4335             


Ala Ser  His Ala Phe His Ser  Val Arg Met Glu Pro  Met Leu Glu 
    4340                 4345                 4350             


Glu Phe  Arg Gln Val Ala Ser  Glu Leu Thr Tyr Arg  Glu Pro Arg 
    4355                 4360                 4365             


Ile Val  Met Ala Ala Gly Glu  Gln Val Thr Thr Pro  Glu Tyr Trp 
    4370                 4375                 4380             


Val Arg  Gln Val Arg Asp Thr  Val Arg Phe Gly Asp  Gln Val Ala 
    4385                 4390                 4395             


Ala Phe  Gly Asp Ala Val Phe  Leu Glu Ile Gly Pro  Asp Arg Thr 
    4400                 4405                 4410             


Leu Ser  Arg Leu Ile Asp Gly  Ile Ala Met Leu Asp  Gly Asp Asp 
    4415                 4420                 4425             


Glu Val  Arg Ala Ala Val Ala  Ala Leu Ala Met Met  His Val Gln 
    4430                 4435                 4440             


Gly Val  Gly Val Asp Trp Pro  Ala Val Leu Gly Thr  Thr Thr Gly 
    4445                 4450                 4455             


Arg Val  Leu Asp Leu Pro Thr  Tyr Ala Phe Gln His  Glu Arg Tyr 
    4460                 4465                 4470             


Trp Met  Val Ser Thr Gly Arg  Pro Gly Gly Glu Gly  His Pro Leu 
    4475                 4480                 4485             


Leu Gly  Trp Gly Val Pro Val  Ala Glu Ala Asp Gly  Arg Leu Tyr 
    4490                 4495                 4500             


Thr Gly  Arg Val Ala Arg Gln  Asp Gly Pro Val Leu  Pro Val Ala 
    4505                 4510                 4515             


Ala Phe  Val Glu Met Ala Phe  Ala Ala Ala Gly Gly  Arg Pro Ile 
    4520                 4525                 4530             


Arg Glu  Leu Ser Val Asp Ala  Leu Leu Tyr Ile Pro  Asp Asp Gly 
    4535                 4540                 4545             


Thr Ala  Glu Leu Gln Thr Trp  Val Ser Glu His Arg  Leu Thr Ile 
    4550                 4555                 4560             


His Ala  Arg Tyr Arg Asp Thr  Glu Pro Trp Thr Arg  Leu Ala Thr 
    4565                 4570                 4575             


Ala Thr  Leu Asp Thr Thr Glu  Pro Ala Thr Thr His  Thr Pro His 
    4580                 4585                 4590             


Pro Gly  Leu Ile Thr Thr Ala  Leu Thr Leu Thr Gly  Asp Glu Ala 
    4595                 4600                 4605             


Pro Ala  Ile Trp His Asp Leu  Thr Leu His Thr Ser  Asn Ala Thr 
    4610                 4615                 4620             


Glu Leu  His Thr His Ile Thr  Pro Gly Asp Asp Gly  Thr Leu Thr 
    4625                 4630                 4635             


Ile Thr  Ala Thr Asp Ala Thr  Gly Gln Pro Val Leu  Thr Ala His 
    4640                 4645                 4650             


Ala Ala  Thr Pro Thr Thr Ile  Pro Val His Thr Pro  Thr Thr Pro 
    4655                 4660                 4665             


Ala Asp  Asp Leu Leu Thr Leu  Thr Trp Thr Gln Ile  Pro Thr Pro 
    4670                 4675                 4680             


Gly Pro  Gly Asp Gly Ala Asp  Ile Ala Val Cys Thr  Ala Leu Pro 
    4685                 4690                 4695             


Asp Pro  Asp Ser Asp Pro Leu  Ala Gln Thr Arg Thr  Leu Thr Ala 
    4700                 4705                 4710             


Gln Val  Leu His Ser Ile Gln  Ala Ser Leu Thr Gly  Glu Asp Arg 
    4715                 4720                 4725             


Pro Leu  Val Val His Thr Gly  Thr Gly Leu Ala Ser  Ala Ala Val 
    4730                 4735                 4740             


Ser Gly  Leu Val Arg Ser Ala  Gln Ser Glu His Pro  Asp Arg Phe 
    4745                 4750                 4755             


Ile Leu  Val Glu Ser Asp Glu  Thr Leu Thr Pro Asp  Gln Leu Ala 
    4760                 4765                 4770             


Ala Val  Ala Gly Leu Asp Glu  Pro Trp Leu Arg Ile  Thr Asp Gly 
    4775                 4780                 4785             


Arg Tyr  Glu Val Pro Arg Leu  Thr Lys Thr Thr Thr  Thr Ala Thr 
    4790                 4795                 4800             


Ala Thr  Ala Val Ser Glu Pro  Val Trp Asp Pro Asp  Gly Thr Val 
    4805                 4810                 4815             


Leu Ile  Thr Gly Gly Ser Gly  Ala Leu Ala Gly Ile  Leu Ala Arg 
    4820                 4825                 4830             


His Leu  Val Thr Glu Arg Gly  Val Arg His Leu Leu  Leu Val Ser 
    4835                 4840                 4845             


Arg Ser  Thr Pro Ser Thr Thr  Leu Ile Asp Glu Leu  Arg Glu Leu 
    4850                 4855                 4860             


Gly Ala  His Val Asp Val Ala  Ala Cys Asp Val Ser  Asp Arg Ala 
    4865                 4870                 4875             


Ala Leu  Ala Arg Val Leu Asp  Gly Val Asp Leu Thr  Ala Val Phe 
    4880                 4885                 4890             


His Thr  Ala Gly Ala Leu Asp  Asp Gly Val Val Glu  Ser Leu Thr 
    4895                 4900                 4905             


Pro Gln  Arg Val Asp Ala Val  Leu Arg Pro Lys Ala  Asp Gly Ala 
    4910                 4915                 4920             


Trp His  Leu His Glu Leu Thr  Arg Asp Arg Asp Leu  Thr Ala Phe 
    4925                 4930                 4935             


Val Met  Tyr Ser Ser Ala Ala  Gly Val Met Gly Ala  Ala Gly Gln 
    4940                 4945                 4950             


Gly Asn  Tyr Ala Ala Ala Asn  Ala Phe Leu Asp Ala  Leu Ala Glu 
    4955                 4960                 4965             


His Arg  Arg Ala Asp Gly Leu  Pro Ala Leu Ser Leu  Ala Trp Gly 
    4970                 4975                 4980             


Met Trp  Asp Asp Ala Asp Gly  Met Thr Ala Ser Leu  Ser Gly Thr 
    4985                 4990                 4995             


Asp His  Arg Arg Ile Arg Arg  Ser Gly Gln Arg Ala  Ile Thr Ala 
    5000                 5005                 5010             


Glu His  Gly Met Arg Leu Leu  Asp Lys Ala Ser Gly  Arg Ser Glu 
    5015                 5020                 5025             


Pro Val  Leu Val Ala Thr Ala  Met Asn Pro Ile Pro  Asp Thr Asp 
    5030                 5035                 5040             


Leu Pro  Ala Leu Leu Arg Ser  Leu Tyr Pro Lys Thr  Ala Arg Lys 
    5045                 5050                 5055             


Ser Gln  Pro Ile Gln Glu Leu  Ser Pro Glu Ala Leu  Leu Lys Ile 
    5060                 5065                 5070             


Val Arg  Asp Ser Ala Ala Met  Val Leu Gly His Ala  Asn Ala Asp 
    5075                 5080                 5085             


Thr Val  Pro Thr Ala Thr Ala  Leu Gln Glu Leu Gly  Leu Asp Ser 
    5090                 5095                 5100             


Leu Thr  Ala Val Glu Leu Arg  Asn Ser Leu Thr Lys  Ala Thr Gly 
    5105                 5110                 5115             


Leu Arg  Leu Pro Ala Thr Met  Ala Phe Asp Tyr Pro  Thr Pro Ala 
    5120                 5125                 5130             


Ala Leu  Ala Gly Arg Leu Gly  Glu Leu Leu Ala Gly  Asp Thr Thr 
    5135                 5140                 5145             


Pro Ala  Thr Ala Ala Val Val  Arg Arg Ala Thr Ala  Ser Asp Glu 
    5150                 5155                 5160             


Pro Leu  Ala Ile Val Gly Met  Ala Cys Arg Leu Pro  Gly Gly Val 
    5165                 5170                 5175             


Ser Thr  Pro Glu Asp Leu Trp  Arg Leu Val Glu Ser  Gly Thr Asp 
    5180                 5185                 5190             


Ala Ile  Thr Asp Phe Pro Thr  Asp Arg Gly Trp Asp  Thr Asp Asp 
    5195                 5200                 5205             


Leu Phe  Asp Pro Asp Pro Asp  Thr Pro Gly Lys Thr  Tyr Thr Val 
    5210                 5215                 5220             


His Gly  Gly Phe Leu Asp Asp  Val Ala Gly Phe Asp  Ala Ser Phe 
    5225                 5230                 5235             


Phe Gly  Ile Ser Pro Arg Glu  Ala Leu Ala Met Asp  Ser Gln Gln 
    5240                 5245                 5250             


Arg Leu  Val Leu Glu Ala Ala  Trp Glu Ala Phe Glu  Arg Ala Gly 
    5255                 5260                 5265             


Ile Glu  Pro Gly Ser Val Arg  Gly Ser Asp Thr Gly  Val Phe Met 
    5270                 5275                 5280             


Gly Ala  Tyr Pro Asp Gly Tyr  Gly Ile Gly Ala Asp  Leu Gly Gly 
    5285                 5290                 5295             


Phe Gly  Ala Thr Ala Gly Ala  Gly Ser Val Leu Ser  Gly Arg Leu 
    5300                 5305                 5310             


Ser Tyr  Phe Phe Gly Leu Glu  Gly Pro Ala Met Thr  Val Asp Thr 
    5315                 5320                 5325             


Ala Cys  Ser Ser Ser Leu Val  Ala Leu His Gln Ala  Gly Ser Ala 
    5330                 5335                 5340             


Leu Arg  Gln Gly Glu Cys Ser  Leu Ala Leu Val Gly  Gly Val Thr 
    5345                 5350                 5355             


Val Ile  Ala Asn Pro Gln Ile  Phe Val Glu Phe Ser  Arg Gln Arg 
    5360                 5365                 5370             


Gly Leu  Ala Ala Asp Gly Arg  Cys Lys Ala Phe Ala  Asp Asn Ala 
    5375                 5380                 5385             


Asp Gly  Thr Gly Phe Ser Glu  Gly Val Gly Val Leu  Leu Val Glu 
    5390                 5395                 5400             


Arg Leu  Ser Asp Ala Gln Ala  Lys Gly His Asn Ile  Leu Ala Leu 
    5405                 5410                 5415             


Val Arg  Ser Ser Ala Val Asn  Gln Asp Gly Ala Ser  Asn Gly Leu 
    5420                 5425                 5430             


Thr Ala  Pro Asn Gly Pro Ser  Gln Gln Arg Val Ile  Arg Gln Ala 
    5435                 5440                 5445             


Leu Ala  Asn Ala Gly Leu Thr  Gly Ala Glu Val Asp  Val Val Glu 
    5450                 5455                 5460             


Ala His  Gly Thr Gly Thr Thr  Leu Gly Asp Pro Ile  Glu Ala Gln 
    5465                 5470                 5475             


Ala Val  Leu Ala Thr Tyr Gly  Gln Asp Arg Asp Gln  Pro Val Leu 
    5480                 5485                 5490             


Leu Gly  Ser Leu Lys Ser Asn  Leu Gly His Thr Gln  Ala Ala Ala 
    5495                 5500                 5505             


Gly Val  Ser Gly Val Ile Lys  Met Val Met Ala Leu  Arg His Asp 
    5510                 5515                 5520             


Thr Val  Pro Ala Thr Leu His  Ile Asp Glu Pro Ser  Arg His Ile 
    5525                 5530                 5535             


Asp Trp  Thr Ala Gly Ala Val  Glu Leu Val Thr Glu  Asn Gln Pro 
    5540                 5545                 5550             


Trp Pro  Val Leu Gly Arg Pro  Arg Arg Ala Ala Val  Ser Ala Phe 
    5555                 5560                 5565             


Gly Val  Ser Gly Thr Asn Ala  His Val Ile Leu Glu  Ser Ala Pro 
    5570                 5575                 5580             


Asp Gln  Pro Pro Ala Pro Ala  Thr Asp Thr Pro Ala  Pro Ala Ala 
    5585                 5590                 5595             


Thr Ala  Gly Val Val Pro Leu  Pro Ile Ser Ala Lys  Thr Val Pro 
    5600                 5605                 5610             


Ala Leu  Ala Asp Leu Glu Asp  Arg Leu Arg Thr Tyr  Leu Thr Thr 
    5615                 5620                 5625             


Thr Pro  Glu Thr Asp Leu Pro  Ala Val Ala Ser Thr  Leu Ala Thr 
    5630                 5635                 5640             


Thr Arg  Ser Leu Phe Glu His  Arg Ala Val Leu Leu  Gly Glu Asp 
    5645                 5650                 5655             


Thr Val  Thr Gly Thr Thr Ile  Pro Asp Pro Arg Ile  Val Phe Val 
    5660                 5665                 5670             


Phe Pro  Gly Gln Gly Trp Gln  Trp Gln Gly Met Gly  Ser Ala Leu 
    5675                 5680                 5685             


Leu Thr  Ser Ser Thr Val Phe  Ala Glu Arg Met Ala  Glu Cys Ala 
    5690                 5695                 5700             


Ala Ala  Leu Ser Glu Phe Val  Asp Trp Asp Leu Leu  Thr Val Leu 
    5705                 5710                 5715             


Asp Asp  Pro Ser Ile Val Asp  Arg Val Asp Val Val  Gln Pro Ala 
    5720                 5725                 5730             


Cys Trp  Ala Val Met Ile Ser  Leu Ala Ala Val Trp  Gln Ala Ala 
    5735                 5740                 5745             


Gly Ile  His Pro Asp Ile Val  Leu Gly His Ser Gln  Gly Glu Ile 
    5750                 5755                 5760             


Ala Ala  Ala Cys Leu Ala Gly  Ala Ile Ser Leu Pro  Asp Ala Ala 
    5765                 5770                 5775             


Arg Ile  Val Ala Gln Arg Ser  Gln Leu Ile Ala His  Gln Leu Thr 
    5780                 5785                 5790             


Gly His  Gly Ala Met Ala Ser  Ile Ser Leu Pro Ala  Asp Asp Ile 
    5795                 5800                 5805             


Pro Thr  Thr Asp Lys Val Trp  Ile Ala Ala His Asn  Gly Thr Ser 
    5810                 5815                 5820             


Thr Val  Ile Ala Gly Asp Pro  Gln Ala Leu Asp Thr  Val Leu Ala 
    5825                 5830                 5835             


Thr Cys  Glu Thr His Gly Ala  Arg Val Arg Lys Ile  Asn Val Asp 
    5840                 5845                 5850             


Tyr Ala  Ser His Thr Pro His  Val Glu Gln Ile Arg  Thr Glu Leu 
    5855                 5860                 5865             


Leu Asp  Ile Thr Thr Asp Ile  Glu Ala His Thr Pro  Thr Val Pro 
    5870                 5875                 5880             


Trp Leu  Ser Thr Thr Asp Asn  Thr Trp Ile Asp Gln  Pro Leu Asp 
    5885                 5890                 5895             


Pro Thr  Tyr Trp Tyr Arg Asn  Leu Arg Glu Pro Val  Arg Phe Gly 
    5900                 5905                 5910             


Pro Ala  Ile Asp Leu Leu Gln  Thr Gln Asp Asn Asn  Leu Phe Ile 
    5915                 5920                 5925             


Glu Ile  Ser Ala Ser Pro Val  Leu Leu Gln Thr Met  Asp Asn Ala 
    5930                 5935                 5940             


Thr Thr  Val Ala Thr Leu Arg  Arg Asp Glu Asp Thr  Thr Gln Arg 
    5945                 5950                 5955             


Leu Leu  Thr Ala Phe Ala Glu  Ala His Val His Gly  Ala Thr Ile 
    5960                 5965                 5970             


Asp Trp  Pro Thr Val Leu Asp  Thr Thr Thr Thr Pro  Val Leu Asp 
    5975                 5980                 5985             


Leu Pro  Thr Tyr Pro Phe Gln  Arg Gln Arg Tyr Trp  Ala Thr Ser 
    5990                 5995                 6000             


Asn Gly  Arg Pro Thr Ser Gln  Gly His Pro Leu Leu  Glu Thr Val 
    6005                 6010                 6015             


Val Ala  Leu Pro Gly Thr His  Gly Val Ala Leu Thr  Gly Arg Ile 
    6020                 6025                 6030             


Ser Leu  Ala Thr His Pro Trp  Leu Thr Asp His Thr  Val Arg Gly 
    6035                 6040                 6045             


Thr Val  Leu Leu Pro Gly Thr  Ala Phe Val Glu Leu  Val Thr His 
    6050                 6055                 6060             


Ala Ala  Thr Glu Val Asn Cys  Gln Val Ile Asp Glu  Leu Ile Ile 
    6065                 6070                 6075             


Glu Ala  Pro Leu Pro Leu Pro  Gln Asn Gly Gly Val  Gln Leu Ser 
    6080                 6085                 6090             


Val Thr  Val Gly Glu Ala Asp  Glu Ala Gly His Arg  Pro Val Thr 
    6095                 6100                 6105             


Val Tyr  Ser Gln Thr Asp Glu  Ser Asp Asp Trp Val  Gln His Val 
    6110                 6115                 6120             


Thr Ala  Thr Ile Ala Pro Gly  Val Ser Ser Ser Glu  Ser Ala Ala 
    6125                 6130                 6135             


Trp Pro  Pro Ala Gln Ala Glu  Pro Val Asn Val Thr  Gly Leu Tyr 
    6140                 6145                 6150             


Asp Asn  Leu Ala Ala Ala Gly  Tyr Glu Tyr Gly Pro  Ala Phe Gln 
    6155                 6160                 6165             


Gly Leu  Gln Thr Ala Trp Arg  Asp Gly Ser Thr Val  Tyr Ala Glu 
    6170                 6175                 6180             


Val Thr  Leu Ala Glu Glu Gln  Ala Gln Glu Thr Ala  Arg Phe Thr 
    6185                 6190                 6195             


Met His  Pro Ala Leu Leu Asp  Ala Ala Leu His Thr  Ile Ala Leu 
    6200                 6205                 6210             


His Asp  Thr Ala Asp Leu Gln  Leu Pro Phe Ser Trp  Arg Gln Val 
    6215                 6220                 6225             


Gln Phe  His Gly Ser Gly Ala  Ala Thr Leu Arg Val  Ala Val Thr 
    6230                 6235                 6240             


Pro Ala  Ala Asp Gly Trp Asn  Ile Arg Ala Thr Asp  Asp Thr Gly 
    6245                 6250                 6255             


Gln Thr  Val Ala Thr Ile Gly  Ser Leu Val Thr Arg  Pro Met Ala 
    6260                 6265                 6270             


Ala Glu  Thr Thr Asn Asp Leu  Leu Ala Leu Thr Trp  Thr Glu Ile 
    6275                 6280                 6285             


Pro Ala  Pro Glu Pro Val Asp  Pro Ala Asp Val Val  Val Phe Thr 
    6290                 6295                 6300             


Ala Leu  Pro Glu Pro Gly Ser  Asp Pro Leu Ala Gln  Thr Arg Ala 
    6305                 6310                 6315             


Leu Thr  Thr Arg Val Leu His  Thr Ile Gln Glu Trp  Leu Ala Asp 
    6320                 6325                 6330             


Asp Asp  Arg Thr Leu Ile Val  Arg Thr Gly Thr Asp  Leu Ala Ser 
    6335                 6340                 6345             


Ala Ala  Val Ser Gly Leu Val  Arg Ser Ala Gln Ser  Glu His Pro 
    6350                 6355                 6360             


Gly Arg  Phe Ile Leu Val Glu  Ser Asp Asp Glu Thr  Leu Thr His 
    6365                 6370                 6375             


Glu Gln  Leu Ala Ala Thr Ala  Gly Leu Asp Glu Pro  Arg Leu Arg 
    6380                 6385                 6390             


Ile Thr  Asp Gly Arg Tyr Glu  Val Pro Arg Leu Thr  Arg Glu Asp 
    6395                 6400                 6405             


Thr Ala  Leu Ala Val Pro Glu  Gly Gly Ala Trp Met  Leu Asp Gln 
    6410                 6415                 6420             


Pro Ser  Arg Ser Gly Thr Leu  Gln Asp Leu Arg Leu  Val Pro Thr 
    6425                 6430                 6435             


Asp Ala  Ala Glu Arg Pro Leu  Arg Pro Gly Glu Val  Arg Val Gly 
    6440                 6445                 6450             


Val Arg  Ala Ala Gly Leu Asn  Phe Arg Asp Val Ala  Val Ala Leu 
    6455                 6460                 6465             


Gly Met  Val Thr Asp Thr Arg  Leu Ile Gly Gly Glu  Gly Ala Gly 
    6470                 6475                 6480             


Val Val  Leu Glu Ala Gly Pro  Gly Val Glu Asp Leu  Arg Pro Gly 
    6485                 6490                 6495             


Asp Arg  Val Phe Gly Leu Leu  Glu Gly Gly Phe Gly  Pro Val Ala 
    6500                 6505                 6510             


Val Ala  Asp Arg Arg Ala Leu  Ala Leu Ile Pro Asp  Gly Trp Ser 
    6515                 6520                 6525             


Phe Thr  Thr Ala Ala Ser Val  Pro Ile Ala Phe Ala  Thr Ala Tyr 
    6530                 6535                 6540             


Tyr Gly  Leu Leu Asp Leu Ala  Gly Leu Arg Ala Gly  Glu Ser Val 
    6545                 6550                 6555             


Leu Ile  His Ala Ala Thr Gly  Gly Val Gly Met Ala  Ala Thr Gln 
    6560                 6565                 6570             


Ile Ala  Arg His Leu Gly Ala  Asp Val Tyr Ala Thr  Ala Ser Thr 
    6575                 6580                 6585             


Gly Lys  Gln His Val Leu Arg  Asp Ala Gly Leu Ser  Asp Asp Arg 
    6590                 6595                 6600             


Ile Ala  Asp Ser Arg Thr Thr  Gly Phe Arg Glu Thr  Phe Arg Asp 
    6605                 6610                 6615             


Ser Thr  Asp Gly Arg Gly Val  Asp Val Val Leu Asn  Ser Leu Lys 
    6620                 6625                 6630             


Gly Asp  Phe Val Asp Ala Ser  Leu Asp Leu Leu Val  Asp Gly Gly 
    6635                 6640                 6645             


Arg Phe  Ile Glu Met Gly Lys  Thr Asp Ile Arg Asp  Ala Ala Gln 
    6650                 6655                 6660             


Ile Pro  Asp Ala Thr Tyr Arg  Ala Phe Asp Leu Met  Asp Ala Gly 
    6665                 6670                 6675             


Pro Glu  Arg Leu Arg Glu Ile  Ile Thr Glu Leu Leu  Ala Leu Phe 
    6680                 6685                 6690             


Glu Gln  Gly Val Leu Arg Pro  Leu Pro Val His Ala  Phe Asp Ile 
    6695                 6700                 6705             


Arg Gln  Ala Arg Asp Ala Phe  Gly Trp Met Ser Arg  Ala Arg His 
    6710                 6715                 6720             


Ile Gly  Lys Leu Val Leu Thr  Ile Pro Gln Pro Ile  Asp Pro Asp 
    6725                 6730                 6735             


Gly Thr  Val Leu Ile Thr Gly  Gly Ser Gly Val Leu  Ala Gly Ile 
    6740                 6745                 6750             


Val Ala  Arg His Leu Val Ile  Ala Glu Gly Leu Arg  Asn Leu Leu 
    6755                 6760                 6765             


Leu Leu  Ser Arg Ser Ala Pro  Ser Glu Ala Leu Ile  Gly Glu Leu 
    6770                 6775                 6780             


Thr Ala  Leu Gly Ala Gln Val  Glu Thr Ala Ala Cys  Asp Ile Ala 
    6785                 6790                 6795             


Asp Arg  Ala Ala Leu Ala Arg  Val Leu Asp Gly Val  Pro Leu Thr 
    6800                 6805                 6810             


Ala Val  Ile His Thr Ala Gly  Ala Leu Asp Asp Gly  Val Val Glu 
    6815                 6820                 6825             


Ser Leu  Asp Pro Gln Arg Leu  Asp Ser Val Leu Thr  Pro Lys Ala 
    6830                 6835                 6840             


Asp Gly  Ala Trp His Leu His  Glu Leu Thr Arg Asp  Arg Asp Leu 
    6845                 6850                 6855             


Ala Ala  Phe Ile Met Tyr Ser  Ser Ala Ala Gly Val  Leu Gly Ala 
    6860                 6865                 6870             


Ala Gly  Gln Gly Asn Tyr Ala  Ala Ala Asn Ala Phe  Val Asp Ala 
    6875                 6880                 6885             


Leu Ala  Val His Arg Arg Phe  Met Gly Leu Pro Ala  Leu Ser Leu 
    6890                 6895                 6900             


Ala Trp  Gly Leu Trp Asp Asp  Thr Ser Ala Leu Thr  Ala Gly Leu 
    6905                 6910                 6915             


Thr Asp  Ser Asp His Asp Arg  Ile Arg Arg Ser Gly  Ala Arg Thr 
    6920                 6925                 6930             


Ile Thr  Ala Glu His Gly Met  Arg Met Phe Asp Ala  Ala Thr Arg 
    6935                 6940                 6945             


Gln Ser  Glu Ala Val Leu Leu  Ala Ala Pro Met Gly  Pro Ile Arg 
    6950                 6955                 6960             


Gly Glu  Asp Val Pro Ala Leu  Leu Arg Gly Leu Ala  Thr Val Arg 
    6965                 6970                 6975             


Gln Pro  Arg Thr Arg Ala Lys  Arg Asp Met Gly Pro  Glu Arg Leu 
    6980                 6985                 6990             


Arg Asp  Arg Leu Asn Gly Arg  Thr Ser Val Glu Gln  His Arg Ile 
    6995                 7000                 7005             


Met Val  Glu Leu Val Leu Ala  His Ala Thr Ser Val  Leu Gly His 
    7010                 7015                 7020             


Glu Ser  Pro Asp Ala Ile Ala  Pro Asp Arg Ala Phe  Lys Asp Leu 
    7025                 7030                 7035             


Gly Met  Asp Ser Leu Thr Ala  Ile Glu Leu Arg Asn  His Leu Val 
    7040                 7045                 7050             


Ala Glu  Thr Gly Val Arg Leu  Pro Ala Thr Thr Ala  Phe Asp His 
    7055                 7060                 7065             


Pro Thr  Ala Asp Asp Leu Ala  Lys Arg Leu Leu Ala  Glu Val Gly 
    7070                 7075                 7080             


Leu Thr  Pro Ala Pro Gln Arg  Thr Glu Ala Asp Ile  Arg Glu Glu 
    7085                 7090                 7095             


Val Val  Val Arg Glu Pro Ala  Gly Asp Asp Ser Trp  Thr Ser Glu 
    7100                 7105                 7110             


Pro Ile  Ala Ile Val Ser Met  Ser Cys Arg Ala Pro  Gly Gly Val 
    7115                 7120                 7125             


Asp Ser  Pro Glu Ser Leu Trp  Arg Leu Val Glu Ser  Gly Thr Asp 
    7130                 7135                 7140             


Ala Ile  Thr Asp Phe Pro Gly  Asp Arg Gly Trp Asp  Val Ala Gly 
    7145                 7150                 7155             


Leu Tyr  Ser Pro Asp Pro Asp  Thr Gly Tyr Lys Thr  Tyr Cys Val 
    7160                 7165                 7170             


Gln Gly  Gly Phe Leu Asp Ala  Ala Ala Asp Phe Asp  Ala Ala Phe 
    7175                 7180                 7185             


Phe Gly  Ile Ser Pro Arg Glu  Ala Leu Gly Met Asp  Pro Gln Gln 
    7190                 7195                 7200             


Arg Leu  Leu Leu Glu Thr Ser  Trp Glu Ala Ile Glu  Arg Ala Arg 
    7205                 7210                 7215             


Ile Asp  Pro Arg Ser Leu Arg  Gly Arg Asn Val Gly  Val Tyr Val 
    7220                 7225                 7230             


Gly Gly  Ala Ala Gln Gly Tyr  Gly Val Gly Ala Ile  Asp Gln Gln 
    7235                 7240                 7245             


Arg Asp  Asn Val Ile Thr Gly  Ser Ser Ile Ser Leu  Leu Ser Gly 
    7250                 7255                 7260             


Arg Leu  Ser Tyr Ala Leu Gly  Leu Glu Gly Pro Gly  Val Thr Val 
    7265                 7270                 7275             


Asp Thr  Ala Cys Ser Ser Ser  Leu Val Ala Leu His  Leu Ala Cys 
    7280                 7285                 7290             


Gln Ala  Leu Arg Gln Arg Glu  Cys Ser Met Ala Leu  Val Ser Gly 
    7295                 7300                 7305             


Val Ser  Val Ile Pro Thr Pro  Asp Val Phe Val Glu  Phe Ser Arg 
    7310                 7315                 7320             


Gln Arg  Gly Leu Ala Ala Asp  Gly Arg Cys Lys Ser  Phe Ser Ala 
    7325                 7330                 7335             


Ser Ala  Asp Gly Thr Ile Trp  Ala Glu Gly Val Gly  Val Leu Val 
    7340                 7345                 7350             


Leu Glu  Arg Leu Ser Glu Ala  Thr Arg Leu Gly His  Arg Val Leu 
    7355                 7360                 7365             


Ala Val  Val Arg Gly Ser Ala  Val Asn Ser Asp Gly  Ala Ser Asn 
    7370                 7375                 7380             


Gly Leu  Thr Ala Pro Asn Gly  Val Ser Gln Gln Arg  Val Ile Arg 
    7385                 7390                 7395             


Gln Ala  Leu Thr Gly Ala Gly  Leu Thr Ala Ala Asp  Val Asp Val 
    7400                 7405                 7410             


Val Glu  Ala His Gly Thr Gly  Thr Lys Leu Gly Asp  Pro Ile Glu 
    7415                 7420                 7425             


Ala Glu  Ala Ile Leu Ala Thr  Tyr Gly Gln Asp Arg  Ser Thr Pro 
    7430                 7435                 7440             


Val Cys  Leu Gly Ser Leu Lys  Ser Asn Ile Gly His  Ala Met Ala 
    7445                 7450                 7455             


Ala Ser  Gly Val Leu Ala Val  Ile Lys Met Val Glu  Ala Met Arg 
    7460                 7465                 7470             


His Gly  Leu Ile Pro Arg Thr  Leu His Val Glu Glu  Pro Ser Pro 
    7475                 7480                 7485             


His Val  Asp Trp Ala Ser Gly  Asp Val Ala Leu Leu  Thr Glu Asn 
    7490                 7495                 7500             


Gln Pro  Trp Pro Asp Asp Ala  Lys Leu Arg Arg Ala  Gly Val Ser 
    7505                 7510                 7515             


Ser Phe  Gly Leu Ser Gly Thr  Asn Ala His Val Val  Leu Glu Gln 
    7520                 7525                 7530             


Tyr Arg  Ala Pro Ala Ala Pro  Asp Ile Thr Thr Thr  Glu His Glu 
    7535                 7540                 7545             


Pro Leu  Ala Trp Thr Leu Ser  Ala Arg Asp Pro Lys  Ala Leu Arg 
    7550                 7555                 7560             


Glu Gln  Ala Gly Arg Leu His  Ala Ala Leu Thr Glu  Ser Pro Gln 
    7565                 7570                 7575             


Trp Arg  Pro Leu Asp Ile Gly  Tyr Ser Leu Ala Thr  Thr Arg Ser 
    7580                 7585                 7590             


Asn Phe  Ala His Arg Ala Val  Ala Val Gly Ser Asp  Arg Glu Asp 
    7595                 7600                 7605             


Leu Leu  Arg Ala Leu Ser Lys  Leu Ala Asp Gly Ser  Ala Trp Pro 
    7610                 7615                 7620             


Ala Leu  Val Thr Ala Thr Ala  Lys Asp Arg Arg Val  Ala Tyr Leu 
    7625                 7630                 7635             


Phe Asp  Gly Gln Gly Ser Gln  Arg Pro Asp Met Gly  Ser Gly Leu 
    7640                 7645                 7650             


Tyr Glu  Arg Phe Pro Ala Phe  Ala Arg Ala Trp Asp  Arg Ile Ser 
    7655                 7660                 7665             


Ala Glu  Phe Gly Lys His Leu  Asp His Ser Leu Thr  Asp Val Tyr 
    7670                 7675                 7680             


Leu Gly  Arg Gly Asp Ala Ala  Thr Ala Asp Leu Val  Asp Asp Thr 
    7685                 7690                 7695             


Leu Tyr  Ala Gln Ala Gly Leu  Phe Thr Met Glu Ile  Ala Leu Phe 
    7700                 7705                 7710             


Glu Leu  Leu Ala Glu Trp Gly  Val Arg Pro Asp Phe  Val Ser Gly 
    7715                 7720                 7725             


His Ser  Ile Gly Glu Thr Ala  Ala Ala Tyr Ala Ala  Gly Val Leu 
    7730                 7735                 7740             


Ser Leu  Glu Asp Val Thr Thr  Leu Ile Val Ala Arg  Gly Arg Ala 
    7745                 7750                 7755             


Leu Arg  Gln Val Pro Pro Gly  Ala Met Val Ala Leu  Arg Ala Gly 
    7760                 7765                 7770             


Glu Asp  Glu Ala Arg Glu Phe  Leu Gly Arg Thr Gly  Ala Ala Leu 
    7775                 7780                 7785             


Asp Leu  Ala Ala Val Asn Ser  Pro Thr Ser Val Val  Val Ser Gly 
    7790                 7795                 7800             


Ala Ser  Glu Ala Val Ala Gly  Phe Arg Ala Arg Trp  Thr Glu Ser 
    7805                 7810                 7815             


Gly Arg  Glu Ala Arg Thr Leu  Asn Val Arg His Ala  Phe His Ser 
    7820                 7825                 7830             


Arg His  Val Glu Ala Val Leu  Gly Glu Phe Arg Glu  Val Leu Glu 
    7835                 7840                 7845             


Ser Leu  Thr Phe Arg Thr Pro  Ala Leu Pro Val Val  Ser Thr Val 
    7850                 7855                 7860             


Thr Gly  Arg Leu Ile Glu Pro  Thr Glu Leu Ser Thr  Ser Glu Tyr 
    7865                 7870                 7875             


Trp Leu  Arg Gln Val Arg Gln  Thr Val Arg Phe His  Asp Ala Val 
    7880                 7885                 7890             


Arg Glu  Leu Ser Gly Gln Gly  Val Gly Thr Phe Val  Glu Ile Gly 
    7895                 7900                 7905             


Pro Ser  Gly Ala Leu Ala Ser  Ala Gly Leu Glu Cys  Leu Gly Asp 
    7910                 7915                 7920             


Glu Ala  Ser Phe His Ala Val  Gln Arg Pro Gly Ser  Pro Gly Asp 
    7925                 7930                 7935             


Val Cys  Leu Met Thr Ala Val  Ala Glu Leu His Ala  Gly Gly Thr 
    7940                 7945                 7950             


Thr Val  Asp Trp Ala Thr Val  Leu Ala Gly Gly Arg  Ala Thr Asp 
    7955                 7960                 7965             


Leu Pro  Val Tyr Pro Phe Gln  His Gly Ser Tyr Trp  Leu Ala Pro 
    7970                 7975                 7980             


Val Thr  Arg Ala Ala Asp Gly  Ala Pro Ser Ala Gly  Val Pro Ala 
    7985                 7990                 7995             


Pro Gly  Glu Tyr Ala Arg Pro  Ser Ala Pro Glu Glu  Pro Arg Thr 
    8000                 8005                 8010             


Met Leu  Glu Leu Val Arg Leu  Glu Ala Ala Ile Ala  Leu Ser Ile 
    8015                 8020                 8025             


Thr Asp  Pro Gly Leu Ile Ala  Asp Asp Ser Ser Phe  Leu Asp Leu 
    8030                 8035                 8040             


Gly Phe  Asp Ser Ile Ser Ala  Leu Arg Leu Ser Asn  Arg Leu Ala 
    8045                 8050                 8055             


Ala Val  Thr Gly Leu Asp Leu  Pro Pro Ser Leu Leu  Phe Asp His 
    8060                 8065                 8070             


Pro Thr  Pro Ala Glu Leu Ala  Ala Arg Leu Asp Glu  Leu Ser Ala 
    8075                 8080                 8085             


Ala Asp  Leu Asp Gly Ala Gly  Val Tyr Ala Leu Leu  Glu Glu Ile 
    8090                 8095                 8100             


Asp Glu  Leu Asp Asp Glu Asp  Leu Asp Met Thr Glu  Glu Glu Gln 
    8105                 8110                 8115             


Thr Ala  Ile Ser Glu Leu Leu  Thr Lys Leu Ser Ala  Lys Trp Ser 
    8120                 8125                 8130             


Arg 
    


<210>  168
<211>  914
<212>  PRT
<213>  Streptomyces hygroscopicus

<400>  168

Met Pro Ala Val Glu Ser Tyr Glu Leu Asp Ala Arg Asp Asp Glu Leu 
1               5                   10                  15      


Arg Arg Leu Glu Glu Ala Val Gly Gln Ala Gly Asn Gly Arg Gly Val 
            20                  25                  30          


Val Val Thr Ile Thr Gly Pro Ile Ala Cys Gly Lys Thr Glu Leu Leu 
        35                  40                  45              


Asp Ala Ala Ala Ala Lys Ser Asp Ala Ile Thr Leu Arg Ala Val Cys 
    50                  55                  60                  


Ser Glu Glu Glu Arg Ala Leu Pro Tyr Ala Leu Ile Gly Gln Leu Ile 
65                  70                  75                  80  


Asp Asn Pro Ala Val Ala Ser Gln Leu Pro Asp Pro Val Ser Met Ala 
                85                  90                  95      


Leu Pro Gly Glu His Leu Ser Pro Glu Ala Glu Asn Arg Leu Arg Gly 
            100                 105                 110         


Asp Leu Thr Arg Thr Leu Leu Ala Leu Ala Ala Glu Arg Pro Val Leu 
        115                 120                 125             


Ile Gly Ile Asp Asp Met His His Ala Asp Thr Ala Ser Leu Asn Cys 
    130                 135                 140                 


Leu Leu His Leu Ala Arg Arg Val Gly Pro Ala Arg Ile Ala Met Val 
145                 150                 155                 160 


Leu Thr Glu Leu Arg Arg Leu Thr Pro Ala His Ser Gln Phe His Ala 
                165                 170                 175     


Glu Leu Leu Ser Leu Gly His His Arg Glu Ile Ala Leu Arg Pro Leu 
            180                 185                 190         


Gly Pro Lys His Ile Ala Glu Leu Ala Arg Ala Gly Leu Gly Pro Asp 
        195                 200                 205             


Val Asp Glu Asp Val Leu Thr Gly Leu Tyr Arg Ala Thr Gly Gly Asn 
    210                 215                 220                 


Leu Asn Leu Gly His Gly Leu Ile Lys Asp Val Arg Glu Ala Trp Ala 
225                 230                 235                 240 


Thr Gly Gly Thr Gly Ile Asn Ala Gly Arg Ala Tyr Arg Leu Ala Tyr 
                245                 250                 255     


Leu Gly Ser Leu Tyr Arg Cys Gly Pro Val Pro Leu Arg Val Ala Arg 
            260                 265                 270         


Val Ala Ala Val Leu Gly Gln Ser Ala Asn Thr Thr Leu Val Arg Trp 
        275                 280                 285             


Ile Ser Gly Leu Asn Ala Asp Ala Val Gly Glu Ala Thr Glu Ile Leu 
    290                 295                 300                 


Thr Glu Gly Gly Leu Leu His Asp Leu Arg Phe Pro His Pro Ala Ala 
305                 310                 315                 320 


Arg Ser Val Val Leu Asn Asp Leu Ser Ala Arg Glu Arg Arg Arg Leu 
                325                 330                 335     


His Arg Ser Ala Leu Glu Val Leu Asp Asp Val Pro Val Glu Val Val 
            340                 345                 350         


Ala His His Gln Ala Gly Ala Gly Phe Ile His Gly Pro Lys Ala Ala 
        355                 360                 365             


Glu Ile Phe Ala Lys Ala Gly Gln Glu Leu His Val Arg Gly Glu Leu 
    370                 375                 380                 


Asp Ala Ala Ser Asp Tyr Leu Gln Leu Ala His His Ala Ser Asp Asp 
385                 390                 395                 400 


Ala Val Thr Arg Ala Ala Leu Arg Val Glu Ala Val Ala Ile Glu Arg 
                405                 410                 415     


Arg Arg Asn Pro Leu Ala Ser Ser Arg His Leu Asp Glu Leu Thr Val 
            420                 425                 430         


Ala Ala Arg Ala Gly Leu Leu Ser Leu Glu His Ala Ala Leu Met Ile 
        435                 440                 445             


Arg Trp Leu Ala Leu Gly Gly Arg Ser Gly Glu Ala Ala Glu Val Leu 
    450                 455                 460                 


Ala Ala Gln Arg Pro Arg Ala Val Thr Asp Gln Asp Arg Ala His Leu 
465                 470                 475                 480 


Arg Ala Ala Glu Val Ser Leu Ala Leu Val Ser Pro Gly Ala Ser Gly 
                485                 490                 495     


Val Ser Pro Gly Ala Ser Gly Pro Asp Arg Arg Pro Arg Pro Leu Pro 
            500                 505                 510         


Pro Asp Glu Leu Ala Asn Leu Pro Lys Ala Ala Arg Leu Cys Ala Ile 
        515                 520                 525             


Ala Asp Asn Ala Val Ile Ser Ala Leu His Gly Arg Pro Glu Leu Ala 
    530                 535                 540                 


Ser Ala Glu Ala Glu Asn Val Leu Lys Gln Ala Asp Ser Ala Ala Asp 
545                 550                 555                 560 


Gly Ala Thr Ala Leu Ser Ala Leu Thr Ala Leu Leu Tyr Ala Glu Asn 
                565                 570                 575     


Thr Asp Thr Ala Gln Leu Trp Ala Asp Lys Leu Val Ser Glu Thr Gly 
            580                 585                 590         


Ala Ser Asn Glu Glu Glu Gly Ala Gly Tyr Ala Gly Pro Arg Ala Glu 
        595                 600                 605             


Thr Ala Leu Arg Arg Gly Asp Leu Ala Ala Ala Val Glu Ala Gly Ser 
    610                 615                 620                 


Ala Ile Leu Asp His Arg Arg Gly Ser Leu Leu Gly Ile Thr Ala Ala 
625                 630                 635                 640 


Leu Pro Leu Ser Ser Ala Val Ala Ala Ala Ile Arg Leu Gly Glu Thr 
                645                 650                 655     


Glu Arg Ala Glu Lys Trp Leu Ala Glu Pro Leu Pro Glu Ala Ile Arg 
            660                 665                 670         


Asp Ser Leu Phe Gly Leu His Leu Leu Ser Ala Arg Gly Gln Tyr Cys 
        675                 680                 685             


Leu Ala Thr Gly Arg His Glu Ser Ala Tyr Thr Ala Phe Arg Thr Cys 
    690                 695                 700                 


Gly Glu Arg Met Arg Asn Trp Gly Val Asp Val Pro Gly Leu Ser Leu 
705                 710                 715                 720 


Trp Arg Val Asp Ala Ala Glu Ala Leu Leu His Gly Arg Asp Arg Asp 
                725                 730                 735     


Glu Gly Arg Arg Leu Ile Asp Glu Gln Leu Thr His Ala Met Gly Pro 
            740                 745                 750         


Arg Ser Arg Ala Leu Thr Leu Arg Val Gln Ala Ala Tyr Ser Pro Gln 
        755                 760                 765             


Ala Gln Arg Val Asp Leu Leu Glu Glu Ala Ala Asp Leu Leu Leu Ser 
    770                 775                 780                 


Cys Asn Asp Gln Tyr Glu Arg Ala Arg Val Leu Ala Asp Leu Ser Glu 
785                 790                 795                 800 


Ala Phe Ser Ala Leu Arg His His Ser Arg Ala Arg Gly Leu Leu Arg 
                805                 810                 815     


Gln Ala Arg His Leu Ala Ala Gln Cys Gly Ala Thr Pro Leu Leu Arg 
            820                 825                 830         


Arg Leu Gly Ala Lys Pro Gly Gly Pro Gly Trp Leu Glu Glu Ser Gly 
        835                 840                 845             


Leu Pro Gln Arg Ile Lys Ser Leu Thr Asp Ala Glu Arg Arg Val Ala 
    850                 855                 860                 


Ser Leu Ala Ala Gly Gly Gln Thr Asn Arg Val Ile Ala Asp Gln Leu 
865                 870                 875                 880 


Phe Val Thr Ala Ser Thr Val Glu Gln His Leu Thr Asn Val Phe Arg 
                885                 890                 895     


Lys Leu Gly Val Lys Gly Arg Gln His Leu Pro Ala Glu Leu Ala Asn 
            900                 905                 910         


Ala Glu 
        


<210>  169
<211>  12
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  169
ctagggggtt gc                                                           12


<210>  170
<211>  6
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  170
gggggt                                                                   6


<210>  171
<211>  2685
<212>  DNA
<213>  Streptomyces hygroscopicus

<400>  171
atgcctgccg tggagtgcta tgaactggac gcccgcgatg acgagctcag aaaactggag       60

gaggttgtga ccgggcgggc caacggccgg ggtgtggtgg tcaccatcac cggaccgatc      120

gcctgcggca agaccgaact gctcgacgca gccgccgcga aggccgacgc catcacgtta      180

cgagcggtct gctccgcgga ggaacaggca ctcccgtacg ccctgatcgg gcagctcatc      240

gacaacccgg cgctcgcctc ccacgcgctg gagccggcct gcccgaccct cccgggcgag      300

cacctgtcgc cggaggccga gaaccggctg cgcagcgacc tcacccgtac cctgctggcg      360

ctcgccgccg aacggccggt gctgatcggc atcgacgagt cacacgcgaa cgctttgtgt      420

ctgctccacc tggcccgaag ggtcggctcg gcccggatcg ccatggtcct caccgagttg      480

cgccggctca ccccggccca ctcacagttc caggccgagc tgctcagcct ggggcaccac      540

cgcgagatcg cgctgcgccc gctcagcccg aagcacaccg ccgagctggt ccgcgccggt      600

ctcggtcccg acgtcgacga ggacgtgctc acggggttgt accgggcgac cggcggcaac      660

ctgaacctca cccgcggact gatcaacgat gtgcgggagg cctgggagac gggagggacg      720

ggcatcagcg cgggccgcgc gtaccggctg gcatacctcg gttccctcta ccgctgcggc      780

ccggtcccgt tgcgggtcgc acgggtggcc gccgtgctgg gccagagcgc caacaccacc      840

ctggtgcgct ggatcagcgg gctcaacgcg gacgcggtgg gcgaggcaac cgagatcctc      900

accgaaggcg gcctgctgca cgacctgcgg ttcccgcacc cggcggcccg ttcggtggta      960

ctcaacgaca tgtccgccca ggaacgacgc cgcctgcacc ggtccgctct ggaagtgctg     1020

gacgacgtgc ccgtggaagt ggtcgcgcac caccaggtcg gcgccggtct cctgcacggc     1080

ccgaaggccg ccgagatatt cgccaaggcc ggccaggagc tgcatgtgcg cggcgagttg     1140

gacaccgcgt ccgactatct gcaactggcc caccaggcct ccgacgacgc cgtcaccggg     1200

atgcgggccg aggccgtggc gatcgagcgc cgccgcaacc cgctggcctc gagccggcac     1260

ctcgacgagc tgaccgtcgt cgcccgtgcc gggctgctct tccccgagca cacggcgctg     1320

atgatccgct ggctgggcgt cggcgggcgg tccggcgagg cagccgggct gctggcctcg     1380

cagcgccccc gtgcggtcac cgaccaggac agggcccata tgcgggccgc cgaggtatcg     1440

ctcgcgctgg tcagccccgg cacgtccggc ccggaccggc ggccgcgtcc gctcacgccg     1500

gatgagctcg cgaacctgcc gaaggcggcc cggctctgcg cgatcgccga caatgccgtc     1560

atgtcggccc tgcgcggtcg tcccgagctc gccgcggccg aggcggagaa cgtcctgcag     1620

cacgccgact cggcggcggc cggcaccacc gccctcgccg cgctgaccgc cttgctgtac     1680

gcggagaaca ccgacaccgc tcagctctgg gccgacaagc tggtctccga gaccggggcg     1740

tcgaacgagg aggaggcggg ctacgcgggg ccgcgcgccg aagccgcgtt gcgtcgcggc     1800

gacctggccg cggcggtcga ggcaggcagc accgttctgg accaccggcg gctctcgacg     1860

ctcggcatca ccgccgcgct accgctgagc agcgcggtgg ccgccgccat ccggctgggc     1920

gagaccgagc gggcggagaa gtggctcgcc cagccgctgc cgcaggccat ccaggacggc     1980

ctgttcggcc tgcacctgct ctcggcgcgc ggccagtaca gcctcgccac gggccagcac     2040

gagtcggcgt acacggcgtt tcgcacctgc ggggaacgta tgcggaactg gggcgttgac     2100

gtgccgggtc tgtccctgtg gcgcgtcgac gccgccgagg cgctgctgca cggccgcgac     2160

cgggacgagg gccgacggct cgtcgacgag caactcaccc gtgcgatggg accccgttcc     2220

cgcgccttga cgctgcgggt gcaggcggcg tacagcccgc cggcgaagcg ggtcgacctg     2280

ctcgatgaag cggccgacct gctgctctcc tgcaacgacc agtacgagcg ggcacgggtg     2340

ctcgccgacc tgagcgagac gttcagcgcg ctccggcacc acagccgggc gcggggactg     2400

cttcggcagg cccggcacct ggccgcccag cgcggcgcga taccgctgct gcgccgactc     2460

ggggccaagc ccggaggccc cggctggctg gaggaatccg gcctgccgca gcggatcaag     2520

tcgctgaccg acgcggagcg gcgggtggcg tcgctggccg ccggcggaca gaccaaccgc     2580

gtgatcgccg accagctctt cgtcacggcc agcacggtgg agcagcacct cacggacgtc     2640

tccactgggt caaggccgcc agcacctgcc gccgaactcg tctag                     2685


<210>  172
<211>  2685
<212>  DNA
<213>  Streptomyces hygroscopicus

<400>  172
atgcctgccg tggagtgcta tgaactggac gcccgcgatg acgagctcag aaaactggag       60

gaggttgtga ccgggcgggc caacggccgg ggtgtggtgg tcaccatcac cggaccgatc      120

gcctgcggca agaccgaact gctcgacgca gccgccgcga aggccgacgc catcacgctg      180

cgagcggtct gctccgcgga ggaacaggca ctcccgtacg ccctgatcgg gcagctcatc      240

gacaacccgg cgctcgcctc ccacgcgctg gagccggcct gcccgaccct cccgggcgag      300

cacctgtcgc cggaggccga gaaccggctg cgcagcgacc tcacccgtac cctgctggcg      360

ctcgccgccg aacggccggt gctgatcggc atcgacgagt cacacgcgaa cgctttgtgt      420

ctgctccacc tggcccgaag ggtcggctcg gcccggatcg ccatggtcct caccgagttg      480

cgccggctca ccccggccca ctcacagttc caggccgagc tgctcagcct ggggcaccac      540

cgcgagatcg cgctgcgccc gctcagcccg aagcacaccg ccgagctggt ccgcgccggt      600

ctcggtcccg acgtcgacga ggacgtgctc acggggttgt accgggcgac cggcggcaac      660

ctgaacctca cccgcggact gatcaacgat gtgcgggagg cctgggagac gggagggacg      720

ggcatcagcg cgggccgcgc gtaccggctg gcatacctcg gttccctcta ccgctgcggc      780

ccggtcccgt tgcgggtcgc acgggtggcc gccgtgctgg gccagagcgc caacaccacc      840

ctggtgcgct ggatcagcgg gctcaacgcg gacgcggtgg gcgaggcaac cgagatcctc      900

accgaaggcg gcctgctgca cgacctgcgg ttcccgcacc cggcggcccg ttcggtggta      960

ctcaacgaca tgtccgccca ggaacgacgc cgcctgcacc ggtccgctct ggaagtgctg     1020

gacgacgtgc ccgtggaagt ggtcgcgcac caccaggtcg gcgccggtct cctgcacggc     1080

ccgaaggccg ccgagatatt cgccaaggcc ggccaggagc tgcatgtgcg cggcgagttg     1140

gacaccgcgt ccgactatct gcaactggcc caccaggcct ccgacgacgc cgtcaccggg     1200

atgcgggccg aggccgtggc gatcgagcgc cgccgcaacc cgctggcctc gagccggcac     1260

ctcgacgagc tgaccgtcgt cgcccgtgcc gggctgctct tccccgagca cacggcgctg     1320

atgatccgct ggctgggcgt cggcgggcgg tccggcgagg cagccgggct gctggcctcg     1380

cagcgccccc gtgcggtcac cgaccaggac agggcccata tgcgggccgc cgaggtatcg     1440

ctcgcgctgg tcagccccgg cacgtccggc ccggaccggc ggccgcgtcc gctcacgccg     1500

gatgagctcg cgaacctgcc gaaggcggcc cggctctgcg cgatcgccga caatgccgtc     1560

atgtcggccc tgcgcggtcg tcccgagctc gccgcggccg aggcggagaa cgtcctgcag     1620

cacgccgact cggcggcggc cggcaccacc gccctcgccg cgctgaccgc cttgctgtac     1680

gcggagaaca ccgacaccgc tcagctctgg gccgacaagc tggtctccga gaccggggcg     1740

tcgaacgagg aggaggcggg ctacgcgggg ccgcgcgccg aagccgcgtt gcgtcgcggc     1800

gacctggccg cggcggtcga ggcaggcagc accgttctgg accaccggcg gctctcgacg     1860

ctcggcatca ccgccgcgct accgctgagc agcgcggtgg ccgccgccat ccggctgggc     1920

gagaccgagc gggcggagaa gtggctcgcc cagccgctgc cgcaggccat ccaggacggc     1980

ctgttcggcc tgcacctgct ctcggcgcgc ggccagtaca gcctcgccac gggccagcac     2040

gagtcggcgt acacggcgtt tcgcacctgc ggggaacgta tgcggaactg gggcgttgac     2100

gtgccgggtc tgtccctgtg gcgcgtcgac gccgccgagg cgctgctgca cggccgcgac     2160

cgggacgagg gccgacggct cgtcgacgag caactcaccc gtgcgatggg accccgttcc     2220

cgcgccttga cgctgcgggt gcaggcggcg tacagcccgc cggcgaagcg ggtcgacctg     2280

ctcgatgaag cggccgacct gctgctctcc tgcaacgacc agtacgagcg ggcacgggtg     2340

ctcgccgacc tgagcgagac gttcagcgcg ctccggcacc acagccgggc gcggggactg     2400

cttcggcagg cccggcacct ggccgcccag cgcggcgcga taccgctgct gcgccgactc     2460

ggggccaagc ccggaggccc cggctggctg gaggaatccg gcctgccgca gcggatcaag     2520

tcgctgaccg acgcggagcg gcgggtggcg tcgctggccg ccggcggaca gaccaaccgc     2580

gtgatcgccg accagctctt cgtcacggcc agcacggtgg agcagcacct cacggacgtc     2640

tccactgggt caaggccgcc agcacctgcc gccgaactcg tctag                     2685


<210>  173
<211>  2772
<212>  DNA
<213>  Streptomyces kanamyceticus

<400>  173
gtggttcctg aagtgcgagc agcccccgac gaactgatcg cccgcgatga cgagctgagc       60

cgcctccaac gggcactcac cagggcgggg agcggaaggg gcggcgtcgt cgccatcacc      120

gggcccatcg ccagcggaaa gacggcgctg ctcgacgccg gagcggccaa gtccggcttc      180

gtcgcactcc gtgcggtgtg ctcctgggaa gagcgcactc tgccgtacgg gatgctgggc      240

cagctcttcg accatcccga actggccgcc caggcgccgg accttgccca cttcacggct      300

tcgtgcgaga gccctcaggc cggtaccgac aaccgcctgc gggccgagtt cacccgcacc      360

ctgctggcgc tcgccgcgga ctggcccgtc ctgatcggca tcgacgacgt gcaccacgcc      420

gacgcggaat cactgcgctg tctgctccac ctcgcccgcc gcatcggccc ggcccgcatc      480

gcggtcgtac tgaccgagct gcgcagaccg acgcccgccg actcccgctt ccaggcggaa      540

ctgctgagcc tgcgctccta ccaggagatc gcgctcagac cgctcaccga ggcgcagacc      600

ggcgaactcg tacgtcggca cctcggcgcg gagacccacg aggacgtctc cgccgatacg      660

ttccgggcga ccggcgggaa cctgctcctc gggcacggtt tgatcaatga catccgggag      720

gcgcggacag cgggacggcc gggggtcgtc gcggggcggg cgtaccggct cgcgtacctc      780

agctcgctct accgctgcgg cccgagcgcg ctgcgtgtcg cccgggcgtc cgccgtgctc      840

ggcgcgagcg ccgaagccgt gctcgtccag cggatgaccg gactgaacaa ggacgcggtc      900

gaacaggtct atgagcagct gaacgaggga cggctgctgc agggcgagcg gtttccgcac      960

ccggcggccc gctccatcgt ccttgacgac ctgtcggccc tggaacgcag aaacctgcac     1020

gagtcggcgc tggagctgct gcgggaccac ggcgtggccg gcaacgtgct cgcccgccac     1080

cagatcggcg ccggccgggt gcacggcgag gaggccgtcg agctgttcac cggggccgca     1140

cgggagcacc acctgcgcgg tgaactggac gacgcggccg gatacctgga actcgcccac     1200

cgtgcctccg acgaccccgt cacgcgcgcc gcactacgcg tcggcgccgc cgcgatcgag     1260

cgcctctgca atccggtacg ggcaggccgg catctgcccg agctgctcac cgcgtcgcgc     1320

gcgggactgc tctccagcga gcacgccgtg tcgctcgccg actggctggc gatgggcggg     1380

cgcccgggcg aggcggccga ggtcctcgcg acgcagcgtc ccgcggccga cagcgagcag     1440

caccgcgcac tcctgcgcag cggcgagttg tccctcgcgc tggtccaccc cggcgcgtgg     1500

gatccgttgc gccggaccga tcggttcgcc gcgggcgggc tcggctcgct tcccggaccc     1560

gcccggcacc gcgcggtcgc cgaccaagcc gtcatcgcgg cgctgcgtgg acgtctcgac     1620

cgggcggacg ccaacgcgga gagcgttctc cagcacaccg acgccacggc ggaccggacc     1680

acggccatca tggcgttgct ggccctgctc tacgcggaga acaccgatgc tgtccagttc     1740

tgggtcgaca aactggccgg tgacgagggc accaggacac cggccgacga ggcggtccac     1800

gcggggttca acgccgagat cgcgctgcgc cgcggcgact tgatgagagc cgtcgagtac     1860

ggcgaggcag cgctcggcca ccggcacctg cccacctggg gaatggccgc cgctctgccg     1920

ctgagcagca ccgtggttgc cgcgatccgg ctcggcgacc tcgacagggc cgagcggtgg     1980

ctcgccgagc cgctgccgca gcagacgccg gagagcctct tcgggctgca cctgctctgg     2040

gcccgcgggc agcaccacct cgcgaccggg cggcacgggg cggcgtacac ggcgttcagg     2100

gaatgcggcg agcggatgcg gcggtgggcc gtcgacgtgc cgggcctggc cctgtggcgg     2160

gtcgacgccg ccgaatcgct gctgctgctc ggccgtgacc gtgccgaagg actgcggctc     2220

gtctccgagc agctgtcccg gccgatgcgc cctcgcgcgc gcgtgcagac gttacgggta     2280

caggcggcct acagtccgcc gccccaacgg atcgacctgc tcgaagaggc cgccgacctg     2340

ctggtcacct gcaacgacca gtacgaactg gcaaacgtac tcagcgactt ggcagaggcc     2400

tccagcatgg tccggcagca cagcagggcg cggggtctgc tccgccgggc acggcacctc     2460

gccacccagt gcggcgccgt gccgctcctg cggcggctcg gcgcggaacc ctcggacatc     2520

ggcggagcct gggacgcgac gctgggacag cggatcgcgt cactgacgga gtcggagcgg     2580

cgggtggccg cgctcgccgc ggtcgggcgt acgaacaggg agatcgccga gcagctgttc     2640

gtcacggcca gcacggtgga acagcacctc acgaacgtgt tccgcaaact ggcggtgaag     2700

ggccgccagc agcttccgaa ggaactggcc gacgtcggcg agccggcgga ccgcgaccgc     2760

cggtgcgggt ag                                                         2772


<210>  174
<211>  2772
<212>  DNA
<213>  Streptomyces kanamyceticus

<400>  174
atggttcctg aagtgcgagc agcccccgac gaactgatcg cccgcgatga cgagctgagc       60

cgcctccaac gggcactcac cagggcgggg agcggaaggg gcggcgtcgt cgccatcacc      120

gggcccatcg ccagcggaaa gacggcgctg ctcgacgccg gagcggccaa gtccggcttc      180

gtcgcactcc gtgcggtgtg ctcctgggaa gagcgcactc tgccgtacgg gatgctgggc      240

cagctcttcg accatcccga actggccgcc caggcgccgg accttgccca cttcacggct      300

tcgtgcgaga gccctcaggc cggtaccgac aaccgcctgc gggccgagtt cacccgcacc      360

ctgctggcgc tcgccgcgga ctggcccgtc ctgatcggca tcgacgacgt gcaccacgcc      420

gacgcggaat cactgcgctg tctgctccac ctcgcccgcc gcatcggccc ggcccgcatc      480

gcggtcgtac tgaccgagct gcgcagaccg acgcccgccg actcccgctt ccaggcggaa      540

ctgctgagcc tgcgctccta ccaggagatc gcgctcagac cgctcaccga ggcgcagacc      600

ggcgaactcg tacgtcggca cctcggcgcg gagacccacg aggacgtctc cgccgatacg      660

ttccgggcga ccggcgggaa cctgctcctc gggcacggtt tgatcaatga catccgggag      720

gcgcggacag cgggacggcc gggggtcgtc gcggggcggg cgtaccggct cgcgtacctc      780

agctcgctct accgctgcgg cccgagcgcg ctgcgtgtcg cccgggcgtc cgccgtgctc      840

ggcgcgagcg ccgaagccgt gctcgtccag cggatgaccg gactgaacaa ggacgcggtc      900

gaacaggtct atgagcagct gaacgaggga cggctgctgc agggcgagcg gtttccgcac      960

ccggcggccc gctccatcgt ccttgacgac ctgtcggccc tggaacgcag aaacctgcac     1020

gagtcggcgc tggagctgct gcgggaccac ggcgtggccg gcaacgtgct cgcccgccac     1080

cagatcggcg ccggccgggt gcacggcgag gaggccgtcg agctgttcac cggggccgca     1140

cgggagcacc acctgcgcgg tgaactggac gacgcggccg gatacctgga actcgcccac     1200

cgtgcctccg acgaccccgt cacgcgcgcc gcactacgcg tcggcgccgc cgcgatcgag     1260

cgcctctgca atccggtacg ggcaggccgg catctgcccg agctgctcac cgcgtcgcgc     1320

gcgggactgc tctccagcga gcacgccgtg tcgctcgccg actggctggc gatgggcggg     1380

cgcccgggcg aggcggccga ggtcctcgcg acgcagcgtc ccgcggccga cagcgagcag     1440

caccgcgcac tcctgcgcag cggcgagttg tccctcgcgc tggtccaccc cggcgcgtgg     1500

gatccgttgc gccggaccga tcggttcgcc gcgggcgggc tcggctcgct tcccggaccc     1560

gcccggcacc gcgcggtcgc cgaccaagcc gtcatcgcgg cgctgcgtgg acgtctcgac     1620

cgggcggacg ccaacgcgga gagcgttctc cagcacaccg acgccacggc ggaccggacc     1680

acggccatca tggcgttgct ggccctgctc tacgcggaga acaccgatgc tgtccagttc     1740

tgggtcgaca aactggccgg tgacgagggc accaggacac cggccgacga ggcggtccac     1800

gcggggttca acgccgagat cgcgctgcgc cgcggcgact tgatgagagc cgtcgagtac     1860

ggcgaggcag cgctcggcca ccggcacctg cccacctggg gaatggccgc cgctctgccg     1920

ctgagcagca ccgtggttgc cgcgatccgg ctcggcgacc tcgacagggc cgagcggtgg     1980

ctcgccgagc cgctgccgca gcagacgccg gagagcctct tcgggctgca cctgctctgg     2040

gcccgcgggc agcaccacct cgcgaccggg cggcacgggg cggcgtacac ggcgttcagg     2100

gaatgcggcg agcggatgcg gcggtgggcc gtcgacgtgc cgggcctggc cctgtggcgg     2160

gtcgacgccg ccgaatcgct gctgctgctc ggccgtgacc gtgccgaagg actgcggctc     2220

gtctccgagc agctgtcccg gccgatgcgc cctcgcgcgc gcgtgcagac gctgcgggta     2280

caggcggcct acagtccgcc gccccaacgg atcgacctgc tcgaagaggc cgccgacctg     2340

ctggtcacct gcaacgacca gtacgaactg gcaaacgtac tcagcgactt ggcagaggcc     2400

tccagcatgg tccggcagca cagcagggcg cggggtctgc tccgccgggc acggcacctc     2460

gccacccagt gcggcgccgt gccgctcctg cggcggctcg gcgcggaacc ctcggacatc     2520

ggcggagcct gggacgcgac gctgggacag cggatcgcgt cactgacgga gtcggagcgg     2580

cgggtggccg cgctcgccgc ggtcgggcgt acgaacaggg agatcgccga gcagctgttc     2640

gtcacggcca gcacggtgga acagcacctc acgaacgtgt tccgcaaact ggcggtgaag     2700

ggccgccagc agcttccgaa ggaactggcc gacgtcggcg agccggcgga ccgcgaccgc     2760

cggtgcgggt ag                                                         2772


<210>  175
<211>  2742
<212>  DNA
<213>  Streptomyces ascomyceticus

<400>  175
gtgatagcgc gcttatctcc cccagacctg atcgcccgcg atgacgagtt cggttccctc       60

caccgggcgc tcacccgagc ggggggcggg cggggcgtcg tcgccgccgt caccgggccg      120

atcgcctgcg gcaagaccga actcctcgac gccgccgcgg ccaaggccgg cttcgtcacc      180

cttcgcgcgg tgtgctccat ggaggagcgg gccctgccgt acggcatgct cggccagctc      240

ctcgaccagc ccgagctggc cgcccggaca ccggagctgg tccggctgac ggcatcgtgc      300

gaaaacctgc cggccgacgt cgacaaccgc ctggggaccg aactcacccg cacggtgctg      360

acgctcgccg cggagcggcc cgtactgatc ggcatcgacg acgtgcacca cgccgacgcg      420

ccgtcgctgc gctgcctgct ccacctcgcg cgccgcatca gccgggcccg tgtcgccatc      480

gtgctgaccg agctgctccg gccgacgccc gcccactccc aattccgggc ggcactgctg      540

agtctgcgcc actaccagga gatcgcgctg cgcccgctca ccgaggcgca gaccaccgaa      600

ctcgtgcgcc ggcacctcgg ccaggacgcg cacgacgacg tggtggccca ggcgttccgg      660

gcgaccggcg gcaacctgct cctcggccac ggcctgatcg acgacatccg ggaggcacgg      720

acacggacct cagggtgcct ggaagtggtc gcggggcggg cgtaccggct cgcctacctc      780

gggtcgctct atcgttgcgg cccggccgcg ctgagcgtcg cccgagcttc cgccgtgctc      840

ggcgagagtg tcgaactcac cctcgtccag cggatgaccg gcctcgacac cgaggcggtc      900

gagcaggccc acgaacagct ggtcgagggg cggctgctgc gggaagggcg gttcccgcac      960

cccgcggccc gctccgtcgt actcgacgac ctctccgccg ccgagcggcg tggcctgcac     1020

gagctggcgc tggaactgct gcgggaccgc ggcgtggcca gcaaggtgct cgcccgccac     1080

cagatgggta ccggccgggt gcacggcgcc gaggtcgccg ggctgttcac cgacgccgcg     1140

cgcgagcacc acctgcgcgg cgagctcgac gaggccgtca cctacctgga gttcgcctac     1200

cgggcctccg acgaccccgc cgtccacgcc gcactgcgcg tcgacaccgc cgccatcgag     1260

cggctctgcg atcccgccag atccggccgg catgtgcccg agctgctcac cgcgtcgcgg     1320

gaacggctcc tctccagcga gcacgccgtg tcgctcgcct gctggctggc gatggacggg     1380

cggccgggcg aggccgccga ggtcctggcg gcccagcgct ccgccgcccc gagcgagcag     1440

ggccgggcgc acctgcgcgt cgcggacctg tccctcgcgc tgatctatcc cggcgcggcc     1500

gatccgccgc gtccggccga tccgccggcc gaggacgagg tcgcctcgtt ttccggagcc     1560

gtccggcacc gcgccgtcgc cgacaaggcc ctgagcaacg cgctgcgcgg ctggtccgaa     1620

caggccgagg ccaaagccga gtacgtgctc cagcactccc gggtcacgac ggaccggacc     1680

acgaccatga tggcgttgct ggccctgctc tacgccgagg acaccgatgc cgtccagtcc     1740

tgggtcgaca agctggccgg tgacgacaac atgcggaccc cggccgacga ggcggtccac     1800

gcggggttcc gcgccgaggc cgcgctgcgc cgcggcgacc tgaccgccgc cgtcgaatgc     1860

ggcgaggccg cgctcgcccc ccgggtcgtg ccctcctggg ggatggccgc cgcattgccg     1920

ctgagcagca ccgtggccgc cgcgatccga ctgggcgacc tggaccgggc ggagcggtgg     1980

ctcgccgagc cgttgccgga ggagacctcc gacagcctct tcggactgca catggtctgg     2040

gcccgtgggc aacaccatct cgcggccggg cggtaccggg cggcgtacaa cgcgttccgg     2100

gactgcgggg agcggatgcg acgctggtcc gtcgacgtgc cgggcctggc cctgtggcgg     2160

gtcgacgccg ccgaagcgct tctgctgctc ggccgcggcc gtgacgaggg gctgaggctc     2220

atctccgagc agctgtcccg gccgatgggg tcccgggcgc gggtgatgac gctgcgggtg     2280

caggcggcct acagtccgcc ggccaagcgg atcgaactgc tcgacgaggc cgccgatctg     2340

ctcatcatgt gccgcgacca gtacgagctg gcccgcgtcc tcgccgacat gggcgaagcg     2400

tgcggcatgc tccggcggca cagccgtgcg cggggactgt tccgccgcgc acggcacctc     2460

gcgacccagt gcggagccgt gccgctcctc cggcggctcg gtggggagtc ctcggacgcg     2520

gacggcaccc aggacgtgac gccggcgcag cggatcacat cgctgaccga ggcggagcgg     2580

cgggtggcgt cgcacgccgc ggtcgggcgc accaacaagg agatcgccag ccagctgttc     2640

gtcacctcca gcacggtgga acagcacctc accaacgtgt tccgcaagct gggggtgaag     2700

ggccgtcagc aactgcccaa ggaactgtcc gacgccggct ga                        2742


<210>  176
<211>  2742
<212>  DNA
<213>  Streptomyces ascomyceticus

<400>  176
atgatagcgc gcctgtctcc cccagacctg atcgcccgcg atgacgagtt cggttccctc       60

caccgggcgc tcacccgagc ggggggcggg cggggcgtcg tcgccgccgt caccgggccg      120

atcgcctgcg gcaagaccga actcctcgac gccgccgcgg ccaaggccgg cttcgtcacc      180

cttcgcgcgg tgtgctccat ggaggagcgg gccctgccgt acggcatgct cggccagctc      240

ctcgaccagc ccgagctggc cgcccggaca ccggagctgg tccggctgac ggcatcgtgc      300

gaaaacctgc cggccgacgt cgacaaccgc ctggggaccg aactcacccg cacggtgctg      360

acgctcgccg cggagcggcc cgtactgatc ggcatcgacg acgtgcacca cgccgacgcg      420

ccgtcgctgc gctgcctgct ccacctcgcg cgccgcatca gccgggcccg tgtcgccatc      480

gtgctgaccg agctgctccg gccgacgccc gcccactccc aattccgggc ggcactgctg      540

agtctgcgcc actaccagga gatcgcgctg cgcccgctca ccgaggcgca gaccaccgaa      600

ctcgtgcgcc ggcacctcgg ccaggacgcg cacgacgacg tggtggccca ggcgttccgg      660

gcgaccggcg gcaacctgct cctcggccac ggcctgatcg acgacatccg ggaggcacgg      720

acacggacct cagggtgcct ggaagtggtc gcggggcggg cgtaccggct cgcctacctc      780

gggtcgctct atcgttgcgg cccggccgcg ctgagcgtcg cccgagcttc cgccgtgctc      840

ggcgagagtg tcgaactcac cctcgtccag cggatgaccg gcctcgacac cgaggcggtc      900

gagcaggccc acgaacagct ggtcgagggg cggctgctgc gggaagggcg gttcccgcac      960

cccgcggccc gctccgtcgt actcgacgac ctctccgccg ccgagcggcg tggcctgcac     1020

gagctggcgc tggaactgct gcgggaccgc ggcgtggcca gcaaggtgct cgcccgccac     1080

cagatgggta ccggccgggt gcacggcgcc gaggtcgccg ggctgttcac cgacgccgcg     1140

cgcgagcacc acctgcgcgg cgagctcgac gaggccgtca cctacctgga gttcgcctac     1200

cgggcctccg acgaccccgc cgtccacgcc gcactgcgcg tcgacaccgc cgccatcgag     1260

cggctctgcg atcccgccag atccggccgg catgtgcccg agctgctcac cgcgtcgcgg     1320

gaacggctcc tctccagcga gcacgccgtg tcgctcgcct gctggctggc gatggacggg     1380

cggccgggcg aggccgccga ggtcctggcg gcccagcgct ccgccgcccc gagcgagcag     1440

ggccgggcgc acctgcgcgt cgcggacctg tccctcgcgc tgatctatcc cggcgcggcc     1500

gatccgccgc gtccggccga tccgccggcc gaggacgagg tcgcctcgtt ttccggagcc     1560

gtccggcacc gcgccgtcgc cgacaaggcc ctgagcaacg cgctgcgcgg ctggtccgaa     1620

caggccgagg ccaaagccga gtacgtgctc cagcactccc gggtcacgac ggaccggacc     1680

acgaccatga tggcgttgct ggccctgctc tacgccgagg acaccgatgc cgtccagtcc     1740

tgggtcgaca agctggccgg tgacgacaac atgcggaccc cggccgacga ggcggtccac     1800

gcggggttcc gcgccgaggc cgcgctgcgc cgcggcgacc tgaccgccgc cgtcgaatgc     1860

ggcgaggccg cgctcgcccc ccgggtcgtg ccctcctggg ggatggccgc cgcattgccg     1920

ctgagcagca ccgtggccgc cgcgatccga ctgggcgacc tggaccgggc ggagcggtgg     1980

ctcgccgagc cgttgccgga ggagacctcc gacagcctct tcggactgca catggtctgg     2040

gcccgtgggc aacaccatct cgcggccggg cggtaccggg cggcgtacaa cgcgttccgg     2100

gactgcgggg agcggatgcg acgctggtcc gtcgacgtgc cgggcctggc cctgtggcgg     2160

gtcgacgccg ccgaagcgct tctgctgctc ggccgcggcc gtgacgaggg gctgaggctc     2220

atctccgagc agctgtcccg gccgatgggg tcccgggcgc gggtgatgac gctgcgggtg     2280

caggcggcct acagtccgcc ggccaagcgg atcgaactgc tcgacgaggc cgccgatctg     2340

ctcatcatgt gccgcgacca gtacgagctg gcccgcgtcc tcgccgacat gggcgaagcg     2400

tgcggcatgc tccggcggca cagccgtgcg cggggactgt tccgccgcgc acggcacctc     2460

gcgacccagt gcggagccgt gccgctcctc cggcggctcg gtggggagtc ctcggacgcg     2520

gacggcaccc aggacgtgac gccggcgcag cggatcacat cgctgaccga ggcggagcgg     2580

cgggtggcgt cgcacgccgc ggtcgggcgc accaacaagg agatcgccag ccagctgttc     2640

gtcacctcca gcacggtgga acagcacctc accaacgtgt tccgcaagct gggggtgaag     2700

ggccgtcagc aactgcccaa ggaactgtcc gacgccggct ga                        2742


<210>  177
<211>  2706
<212>  DNA
<213>  Micromonospora sp. S92-306401

<400>  177
gtggagtttt acgacctggt cgcccgcgat gacgagctca gaaggttgga ccaggccctc       60

ggccgcgccg ccggcggacg gggtgtcgtg gtcaccgtca ccggaccggt cggctgcggc      120

aagaccgaac tgctggacgc ggccgcggcc gaggaggaat tcatcacgtt gcgtgcggtc      180

tgctcggccg aggagcgggc cctgccgtac gccgtgatcg gccaactcct cgaccatccc      240

gtactctccg cacgcgcgcc cgacctggcc tgcgtgacgg ctccgggccg gacgctgccg      300

gccgacaccg agaaccgcct gcgccgcgac ctcacccggg ccctgctggc cctggcctcc      360

gaacgaccgg ttctgatctg catcgacgac gtgcaccagg ccgacaccgc ctcgctgaac      420

tgcctgctgc acctggcccg gcgggtcgcc tcggcccgga tcgccatgat cctcaccgag      480

ttgcgccggc tcaccccggc tcactcccgg ttcgaggcgg aactgctcag cctgcggcac      540

cgccacgaga tcgcgctgcg tcccctcggc ccggccgaca ccgccgaact ggcccgcgcc      600

cggctcggcg ccggcgtcac cgccgacgag ctggcccagg tccacgaggc caccagcggg      660

aaccccaacc tggtcggagg cctggtcaac gacgtgcgag aggcctgggc ggccggtggc      720

acgggcattg cggcggggcg ggcgtaccgg ctggcgtacc tcagctccgt gtaccgctgt      780

ggtccggtcc cgttgcggat cgcccaggcg gcggcggtgc tgggtcccag cgccaccgtc      840

acgctggtgc gccggatcag cgggctcgac gccgagacgg tggacgaggc gaccgcgatc      900

ctcaccgagg gcggcctgct ccgggaccac cggttcccgc atccggcggc ccgctcggtc      960

gtactcgacg acatgtccgc gcaggaacgc cgccgcctgc accggtccac gctggacgtg     1020

ctggacggcg tacccgtcga cgtgctcgcg caccaccagg ccggcgccgg tctgctgcac     1080

ggcccgcagg cggccgagat gttcgcccgg gccagccagg agctgcgggt acgcggcgag     1140

ctggacgccg cgaccgagta cctgcaactg gcctaccggg cctccgacga cgccggcgcc     1200

cgggccgccc tgcaggtgga gaccgtggcc ggcgagcgcc gccgcaaccc gctggccgcc     1260

agccggcacc tggacgagct ggccgccgcc gcccgggccg gcctgctgtc ggccgagcac     1320

gccgccctgg tcgtgcactg gctggccgac gccggacgac ccggcgaggc cgccgaggtg     1380

ctggcgctgc agcgggcgct ggccgtcacc gaccacgacc gggcccgcct gcgggcggcc     1440

gaggtgtcgc tcgcgctgtt ccaccccggc gtccccggtt cggacccgcg gcccctcgcg     1500

ccggaggagc tcgcgagcct gtccctgtcg gcccggcacg gtgtgaccgc cgacaacgcg     1560

gtgctggcgg cgctgcgcgg ccgtcccgag tcggccgccg ccgaggcgga gaacgtgctg     1620

cgcaacgccg acgccgccgc gtccggcccg accgccctgg ccgcgctgac ggccctgctc     1680

tacgccgaga acaccgacgc cgcccagctc tgggcggaca agctggccgc gggcatcggg     1740

gcgggggagg gggaggccgg ctacgcgggg ccgcggaccg tggccgccct gcgtcgcggc     1800

gacctgacca ccgcggtcca ggcggccggc gcggtcctgg accgcggccg gccgtcgtcg     1860

ctcggcatca ccgccgtgtt gccgttgagc ggcgcggtcg ccgccgcgat ccggctgggc     1920

gagctcgagc gggccgagaa gtggctggcc gagccgctgc ccgaagccgt ccacgacagc     1980

ctgttcggcc tgcacctgct gatggcgcgg ggccgctaca gcctcgcggt gggccggcac     2040

gaggcggcgt acgccgcgtt ccgggactgc ggtgaacgga tgcgccggtg ggacgtcgac     2100

gtgcccgggc tggccctgtg gcgggtggac gcggccgagg cgctgctgcc cggcgatgac     2160

cgggcggagg gccggcggct gatcgacgag cagctcaccc ggccgatggg gccccggtca     2220

cgagccctga ccctgcgggt acgagcggcc tacgccccgc cggcgaaacg gatcgacctg     2280

ctcgacgaag cggccgacct gctgctctcc agcaacgacc agtacgagcg ggcacgggtg     2340

ctggccgacc tgagcgaggc gttcagcgcg ctccggcaga acggccgggc gcgcggcatc     2400

ctgcggcagg cccggcacct ggccgcccag tgcggggcgg tccccctgct gcgccggctg     2460

ggcgtcaagg ccggccggtc cggtcggctc ggccggccgc cgcagggaat ccgctccctg     2520

accgaggccg agcgccgggt ggccacgctg gccgccgccg ggcagaccaa ccgggagatc     2580

gccgaccagc tcttcgtcac cgccagcacg gtcgagcagc acctcaccaa cgtgttccgc     2640

aagctcggcg tgaagggccg ccagcaattg ccggccgagc tggccgacct gcggccgccg     2700

ggctga                                                                2706


<210>  178
<211>  2706
<212>  DNA
<213>  Micromonospora sp. S92-306401

<400>  178
atggagtttt acgacctggt cgcccgcgat gacgagctca gaaggttgga ccaggccctc       60

ggccgcgccg ccggcggacg gggtgtcgtg gtcaccgtca ccggaccggt cggctgcggc      120

aagaccgaac tgctggacgc ggccgcggcc gaggaggaat tcatcacgtt gcgtgcggtc      180

tgctcggccg aggagcgggc cctgccgtac gccgtgatcg gccaactcct cgaccatccc      240

gtactctccg cacgcgcgcc cgacctggcc tgcgtgacgg ctccgggccg gacgctgccg      300

gccgacaccg agaaccgcct gcgccgcgac ctcacccggg ccctgctggc cctggcctcc      360

gaacgaccgg ttctgatctg catcgacgac gtgcaccagg ccgacaccgc ctcgctgaac      420

tgcctgctgc acctggcccg gcgggtcgcc tcggcccgga tcgccatgat cctcaccgag      480

ttgcgccggc tcaccccggc tcactcccgg ttcgaggcgg aactgctcag cctgcggcac      540

cgccacgaga tcgcgctgcg tcccctcggc ccggccgaca ccgccgaact ggcccgcgcc      600

cggctcggcg ccggcgtcac cgccgacgag ctggcccagg tccacgaggc caccagcggg      660

aaccccaacc tggtcggagg cctggtcaac gacgtgcgag aggcctgggc ggccggtggc      720

acgggcattg cggcggggcg ggcgtaccgg ctggcgtacc tcagctccgt gtaccgctgt      780

ggtccggtcc cgttgcggat cgcccaggcg gcggcggtgc tgggtcccag cgccaccgtc      840

acgctggtgc gccggatcag cgggctcgac gccgagacgg tggacgaggc gaccgcgatc      900

ctcaccgagg gcggcctgct ccgggaccac cggttcccgc atccggcggc ccgctcggtc      960

gtactcgacg acatgtccgc gcaggaacgc cgccgcctgc accggtccac gctggacgtg     1020

ctggacggcg tacccgtcga cgtgctcgcg caccaccagg ccggcgccgg tctgctgcac     1080

ggcccgcagg cggccgagat gttcgcccgg gccagccagg agctgcgggt acgcggcgag     1140

ctggacgccg cgaccgagta cctgcaactg gcctaccggg cctccgacga cgccggcgcc     1200

cgggccgccc tgcaggtgga gaccgtggcc ggcgagcgcc gccgcaaccc gctggccgcc     1260

agccggcacc tggacgagct ggccgccgcc gcccgggccg gcctgctgtc ggccgagcac     1320

gccgccctgg tcgtgcactg gctggccgac gccggacgac ccggcgaggc cgccgaggtg     1380

ctggcgctgc agcgggcgct ggccgtcacc gaccacgacc gggcccgcct gcgggcggcc     1440

gaggtgtcgc tcgcgctgtt ccaccccggc gtccccggtt cggacccgcg gcccctcgcg     1500

ccggaggagc tcgcgagcct gtccctgtcg gcccggcacg gtgtgaccgc cgacaacgcg     1560

gtgctggcgg cgctgcgcgg ccgtcccgag tcggccgccg ccgaggcgga gaacgtgctg     1620

cgcaacgccg acgccgccgc gtccggcccg accgccctgg ccgcgctgac ggccctgctc     1680

tacgccgaga acaccgacgc cgcccagctc tgggcggaca agctggccgc gggcatcggg     1740

gcgggggagg gggaggccgg ctacgcgggg ccgcggaccg tggccgccct gcgtcgcggc     1800

gacctgacca ccgcggtcca ggcggccggc gcggtcctgg accgcggccg gccgtcgtcg     1860

ctcggcatca ccgccgtgtt gccgttgagc ggcgcggtcg ccgccgcgat ccggctgggc     1920

gagctcgagc gggccgagaa gtggctggcc gagccgctgc ccgaagccgt ccacgacagc     1980

ctgttcggcc tgcacctgct gatggcgcgg ggccgctaca gcctcgcggt gggccggcac     2040

gaggcggcgt acgccgcgtt ccgggactgc ggtgaacgga tgcgccggtg ggacgtcgac     2100

gtgcccgggc tggccctgtg gcgggtggac gcggccgagg cgctgctgcc cggcgatgac     2160

cgggcggagg gccggcggct gatcgacgag cagctcaccc ggccgatggg gccccggtca     2220

cgagccctga ccctgcgggt acgagcggcc tacgccccgc cggcgaaacg gatcgacctg     2280

ctcgacgaag cggccgacct gctgctctcc agcaacgacc agtacgagcg ggcacgggtg     2340

ctggccgacc tgagcgaggc gttcagcgcg ctccggcaga acggccgggc gcgcggcatc     2400

ctgcggcagg cccggcacct ggccgcccag tgcggggcgg tccccctgct gcgccggctg     2460

ggcgtcaagg ccggccggtc cggtcggctc ggccggccgc cgcagggaat ccgctccctg     2520

accgaggccg agcgccgggt ggccacgctg gccgccgccg ggcagaccaa ccgggagatc     2580

gccgaccagc tcttcgtcac cgccagcacg gtcgagcagc acctcaccaa cgtgttccgc     2640

aagctcggcg tgaagggccg ccagcaattg ccggccgagc tggccgacct gcggccgccg     2700

ggctga                                                                2706


<210>  179
<211>  2616
<212>  DNA
<213>  Streptomyces violaceusniger

<400>  179
gtggtcaccg tcaccggccc aatcgcctgc ggcaagacag aactgcttga cgcggctgcc       60

gcgaaggctg aggccatcat tctgcgcgcg gtctgcgcgc cagaagagcg ggctatgccg      120

tacgccatga tcgggcagct catcgacgac ccggcgctcg cgcatcgggc gccggggctg      180

gctgatcgga tagcccaggg cgggcagctg tcgctgaggg ccgagaaccg actgcgcagg      240

gatctcaccc gtgccctgct ggcgcttgcc gtcgaccggc ctgtgctgat cggcgtcgac      300

gatgtgcatc acgccgacac cgcctctttg aactgtctgc tgcatttggc gcgccgggtc      360

cgtccggccc ggatatccat gatcttcacc gagttgcgca gcctcacccc tactcagtca      420

cggttcaagg cggagctgct cagcctgccg taccaccacg agatcgcgct gcgtccgttc      480

ggaccggagc aatcggcgga gctggcccgc gccgccttcg gcccgggcct cgccgaggat      540

gtgctcgtgg ggttgtataa aacgaccagg ggcaatctga gtctcagccg tggactgatc      600

agcgatgtgc gggaggccct ggccaacgga gagagcgcct tcgaggcggg ccgcgcgttc      660

cggctggcgt acctcggctc gctctaccgc tgtggcccgg tcgcgctgcg ggtcgcccga      720

gtggctgccg tgctgggccc gagcgccacc accacgctgg tgcgccgtct aagcgggctc      780

agcgcggaga cgatagaccg ggcaaccaag atcctcaccg agggcgggct gctgctcgac      840

cagcagttcc cgcacccggc cgcccgctcg gtggtgcttg atgacatgtc cgcccaggaa      900

cgacgcggcc tgcacactct cgccctggaa ctgctggacg aggcgccggt tgaagtgctc      960

gcgcaccacc aggtcggcgc cggtctcata cacgggccca aggctgcgga gatgttcgcc     1020

aaggccggca aggctctggt cgtacgcaac gagttgggcg acgcggcaga atacctgcaa     1080

ctggctcacc gggcctccga cgatgtctcc acccgggccg ccttacgggt cgaggccgtg     1140

gcgatcgagc gccgccgcaa tccgctggcc tccagtcggc acatggacga gctgagcgcc     1200

gccggccgcg ccggtctgct ttcccccaag catgcggcgc tggccgtctt ctggctggcc     1260

gacggcgggc gatccggcga ggcagccgag gtgctggcgt cggaacgccc gctagcgacc     1320

accgatcaga accgggccca cttgcgattt gtcgaggtga ctctcgcgct gttctctccc     1380

ggcgccttcg gatcggaccg gcgcccacct ccgctgacgc cggacgaact cgccagcctg     1440

ccgaaggcgg cctggcaatg cgcggtcgcc gacaacgcgg ccatgaccgc cttgcacggt     1500

catccagaac ttgccaccgc tcaggcggaa acagttctgc ggcaggctga ttcggcagcc     1560

gacgcgatcc ccgccgcgct gatcgccctg ttgtacgcgg agaacaccga gtccgctcat     1620

atctgggccg acaagctggg cagcacgaat ggcggggtat cgaacgaggc ggaagcgggc     1680

tacgccggcc cgtgcgccga gatcgccctg cggcgcggcg acctggccac ggcgttcgag     1740

gctggtagca ccgtcctgga cgaccggtcg ctgccgtcgc tcggcatcac cgccgcattg     1800

ctgttgagca gcaagacggc cgccgctgtc cggctgggcg aactcgagcg tgcggagaag     1860

ctgctcgccg agccgcttcc gaacggcgtc caggacagcc ttttcggtct gcacctgctc     1920

tcggcatacg gccagtacag cctcgcgatg ggccgatatg aatcggctct ccgggcgttt     1980

cacacctgcg gagaacgtat gcgcagctgg gatgttgacg tgcctggtct ggccctgtgg     2040

cgtgtcgacg ccgccgaggc gctgctcagc ctcgaccgga acgagggcca gcggctcatc     2100

gacgaacaac tcacccgtcc gatggggcct cgttcccgcg cgttaacgct gcggatcaag     2160

gcggcatacc tcccgcggac gaagcggatc cccctgctcc atgaggcggc cgagctgctg     2220

ctcccctgcc ccgacccgta cgagcaagcg cgggtgctcg ccgatctggg cgacacgctc     2280

agcgcgctca gacgctatag ccgggcgcgg ggagttctcc ggcaggctcg tcacctggcc     2340

gcccagtgcg gtgctgtccc gctgctgcgc aggctcgggg gcgagcccgg ccggatcgac     2400

gacgccggcc tgccgcagcg gagcacatcg ttgaccgatg cggagcggcg ggtggcggcg     2460

ctggccgcgg ccggacagac caaccgggag atcgccaaac agctgttcgt cacggccagc     2520

acagtggaac agcacctcac aagcgtcttc cgcaaactgg gggtcaaggg tcgcaagcag     2580

ctgccgaccg cgctggccga cgtggaacag acctga                               2616


<210>  180
<211>  2721
<212>  DNA
<213>  Streptomyces violaceusniger

<400>  180
atgtatagcg gtacctgccg tgaaggatac gaactcgtcg cacgcgagga cgaactcggc       60

attctacaga ggtctctgga acaagcgagc agcggccagg gcgtcgtggt caccgtcacc      120

ggcccaatcg cctgcggcaa gacagaactg cttgacgcgg ctgccgcgaa ggctgaggcc      180

atcattctgc gcgcggtctg cgcgccagaa gagcgggcta tgccgtacgc catgatcggg      240

cagctcatcg acgacccggc gctcgcgcat cgggcgccgg ggctggctga tcggatagcc      300

cagggcgggc agctgtcgct gagggccgag aaccgactgc gcagggatct cacccgtgcc      360

ctgctggcgc ttgccgtcga ccggcctgtg ctgatcggcg tcgacgatgt gcatcacgcc      420

gacaccgcct ctttgaactg tctgctgcat ttggcgcgcc gggtccgtcc ggcccggata      480

tccatgatct tcaccgagtt gcgcagcctc acccctactc agtcacggtt caaggcggag      540

ctgctcagcc tgccgtacca ccacgagatc gcgctgcgtc cgttcggacc ggagcaatcg      600

gcggagctgg cccgcgccgc cttcggcccg ggcctcgccg aggatgtgct cgtggggttg      660

tataaaacga ccaggggcaa tctgagtctc agccgtggac tgatcagcga tgtgcgggag      720

gccctggcca acggagagag cgccttcgag gcgggccgcg cgttccggct ggcgtacctc      780

ggctcgctct accgctgtgg cccggtcgcg ctgcgggtcg cccgagtggc tgccgtgctg      840

ggcccgagcg ccaccaccac gctggtgcgc cgtctaagcg ggctcagcgc ggagacgata      900

gaccgggcaa ccaagatcct caccgagggc gggctgctgc tcgaccagca gttcccgcac      960

ccggccgccc gctcggtggt gcttgatgac atgtccgccc aggaacgacg cggcctgcac     1020

actctcgccc tggaactgct ggacgaggcg ccggttgaag tgctcgcgca ccaccaggtc     1080

ggcgccggtc tcatacacgg gcccaaggct gcggagatgt tcgccaaggc cggcaaggct     1140

ctggtcgtac gcaacgagtt gggcgacgcg gcagaatacc tgcaactggc tcaccgggcc     1200

tccgacgatg tctccacccg ggccgccctg cgggtcgagg ccgtggcgat cgagcgccgc     1260

cgcaatccgc tggcctccag tcggcacatg gacgagctga gcgccgccgg ccgcgccggt     1320

ctgctttccc ccaagcatgc ggcgctggcc gtcttctggc tggccgacgg cgggcgatcc     1380

ggcgaggcag ccgaggtgct ggcgtcggaa cgcccgctag cgaccaccga tcagaaccgg     1440

gcccacttgc gatttgtcga ggtgactctc gcgctgttct ctcccggcgc cttcggatcg     1500

gaccggcgcc cacctccgct gacgccggac gaactcgcca gcctgccgaa ggcggcctgg     1560

caatgcgcgg tcgccgacaa cgcggccatg accgccttgc acggtcatcc agaacttgcc     1620

accgctcagg cggaaacagt tctgcggcag gctgattcgg cagccgacgc gatccccgcc     1680

gcgctgatcg ccctgttgta cgcggagaac accgagtccg ctcatatctg ggccgacaag     1740

ctgggcagca cgaatggcgg ggtatcgaac gaggcggaag cgggctacgc cggcccgtgc     1800

gccgagatcg ccctgcggcg cggcgacctg gccacggcgt tcgaggctgg tagcaccgtc     1860

ctggacgacc ggtcgctgcc gtcgctcggc atcaccgccg cattgctgtt gagcagcaag     1920

acggccgccg ctgtccggct gggcgaactc gagcgtgcgg agaagctgct cgccgagccg     1980

cttccgaacg gcgtccagga cagccttttc ggtctgcacc tgctctcggc atacggccag     2040

tacagcctcg cgatgggccg atatgaatcg gctctccggg cgtttcacac ctgcggagaa     2100

cgtatgcgca gctgggatgt tgacgtgcct ggtctggccc tgtggcgtgt cgacgccgcc     2160

gaggcgctgc tcagcctcga ccggaacgag ggccagcggc tcatcgacga acaactcacc     2220

cgtccgatgg ggcctcgttc ccgcgcgctg acgctgcgga tcaaggcggc atacctcccg     2280

cggacgaagc ggatccccct gctccatgag gcggccgagc tgctgctccc ctgccccgac     2340

ccgtacgagc aagcgcgggt gctcgccgat ctgggcgaca cgctcagcgc gctcagacgc     2400

tatagccggg cgcggggagt tctccggcag gctcgtcacc tggccgccca gtgcggtgct     2460

gtcccgctgc tgcgcaggct cgggggcgag cccggccgga tcgacgacgc cggcctgccg     2520

cagcggagca catcgttgac cgatgcggag cggcgggtgg cggcgctggc cgcggccgga     2580

cagaccaacc gggagatcgc caaacagctg ttcgtcacgg ccagcacagt ggaacagcac     2640

ctcacaagcg tcttccgcaa actgggggtc aagggtcgca agcagctgcc gaccgcgctg     2700

gccgacgtgg aacagacctg a                                               2721


<210>  181
<211>  2745
<212>  DNA
<213>  Streptomyces hygroscopicus

<400>  181
atgcctgccg tggagagcta tgaactggac gcccgcgatg acgagctcag aagactggag       60

gaggcggtag gccaggcggg caacggccgg ggtgtggtgg tcaccatcac cgggccgatc      120

gcctgcggca agaccgaact gctcgacgcg gccgccgcga agagcgacgc catcacatta      180

cgtgcggtct gctccgagga ggaacgggcc ctcccgtacg ccctgatcgg gcagctcatc      240

gacaacccgg cggtcgcctc ccagctgccg gatccggtct ccatggccct cccgggcgag      300

cacctgtcgc cggaggccga gaaccggctg cgcggcgacc tcacccgtac cctgctggcg      360

ctcgccgccg aacggccggt gctgatcggc atcgacgaca tgcaccacgc cgacaccgcc      420

tctttgaact gcctgctcca cctggcccgg agggtcggcc cggcccggat cgccatggtc      480

ctcaccgagc tgcgccggct caccccggcc cactcccagt tccacgccga gctgctcagc      540

ctggggcacc accgcgagat cgcgctgcgc ccgctcggcc cgaagcacat cgccgagctg      600

gcccgcgccg gcctcggtcc cgatgtcgac gaggacgtgc tcacggggtt gtaccgggcg      660

accggcggca acctgaacct cggccacgga ctgatcaagg atgtgcggga ggcctgggcg      720

acgggcggga cgggcatcaa cgcgggccgc gcgtaccggc tggcgtacct cggttccctc      780

taccgctgcg gcccggtccc gttgcgggtc gcacgggtgg ccgccgtgct gggccagagc      840

gccaacacca ccctggtgcg ctggatcagc gggctcaacg cggacgcggt gggcgaggcg      900

accgagatcc tcaccgaggg cggcctgctg cacgacctgc ggttcccgca tccggcggcc      960

cgttcggtcg tactcaacga cctgtccgcc cgggaacgcc gccgactgca ccggtccgct     1020

ctggaagtgc tggatgacgt acccgttgaa gtggtcgcgc accaccaggc cggtgccggt     1080

ttcatccacg gtcccaaggc cgccgagatc ttcgccaagg ccggccagga gctgcatgtg     1140

cgcggcgagc tggacgccgc gtccgactat ctgcaactgg cccaccacgc ctccgacgac     1200

gccgtcaccc gggccgcgct gcgggtcgag gccgtggcga tcgagcgccg ccgcaacccg     1260

ctggcctcca gccgccacct cgacgagctg accgtcgccg cccgtgccgg tctgctctcc     1320

ctcgagcacg ccgcgctgat gatccgctgg ctggctctcg gcgggcggtc cggcgaggcg     1380

gccgaggtgc tggccgcgca gcgcccgcgt gcggtcaccg accaggacag ggcccacctg     1440

cgggccgccg aggtatcgct ggcgctggtc agcccgggcg cgtccggcgt cagcccgggt     1500

gcgtccggcc cggatcggcg gccgcgtccg ctcccgccgg atgagctcgc gaacctgccg     1560

aaggcggccc ggctttgtgc gatcgccgac aacgccgtca tatcggccct gcacggtcgt     1620

cccgagcttg cctcggccga ggcggagaac gtcctgaagc aggctgactc ggcggcggac     1680

ggcgccaccg ccctctccgc gctgacggcc ttgctgtacg cggagaacac cgacaccgct     1740

cagctctggg ccgacaagct cgtctccgag accggggcgt cgaacgagga ggaaggcgcg     1800

ggctacgcgg ggccgcgcgc cgagaccgcg ttgcgccgcg gcgacctggc cgcggcggtc     1860

gaggcgggca gcgccattct ggaccaccgg cgggggtcgt tgctcggcat caccgccgcg     1920

ctaccgctga gcagcgcggt agccgccgcc atccggctgg gcgagaccga gcgggcggag     1980

aagtggctcg ccgagccgct gccggaggcc attcgggaca gcctgttcgg gctgcacctg     2040

ctctcggcgc gcggccagta ctgcctcgcg acgggccggc acgagtcggc gtacacggcg     2100

ttccgcacct gcggggaacg gatgcggaac tggggcgtcg acgtgccggg tctgtccctg     2160

tggcgcgtcg acgccgccga ggcgctgctg cacggccgcg accgggacga gggccgacgg     2220

ctcatcgacg agcagctcac ccatgcgatg ggaccccgtt cccgcgcttt gacgctgcgg     2280

gtgcaggcgg cgtacagccc gcaggcgcag cgggtcgacc tgctcgaaga ggcggccgac     2340

ctgctgctct cctgcaacga ccagtacgag cgggcgcggg tgctcgccga tctgagcgag     2400

gcgttcagcg cgctcaggca ccacagccgg gcgcggggac tgctccggca ggcccggcac     2460

ctggccgccc agtgcggcgc gaccccgctg ctgcgccggc tcggggccaa gcccggaggc     2520

cccggctggc tggaggaatc cggcctgccg cagcggatca agtcgctgac cgacgcggag     2580

cggcgggtgg cgtcgctggc cgccggcggc cagaccaacc gcgtgatcgc cgaccagctc     2640

ttcgtcacgg ccagcacggt ggagcagcac ctcacgaacg tcttccgcaa gctgggcgtc     2700

aagggccgcc agcacctgcc ggccgaactc gccaacgcgg aatag                     2745


<210>  182
<211>  2745
<212>  DNA
<213>  Streptomyces hygroscopicus

<400>  182
atgcctgccg tggagagcta tgaactggac gcccgcgatg acgagctcag aagactggag       60

gaggcggtag gccaggcggg caacggccgg ggtgtggtgg tcaccatcac cgggccgatc      120

gcctgcggca agaccgaact gctcgacgcg gccgccgcga agagcgacgc catcacactg      180

cgtgcggtct gctccgagga ggaacgggcc ctcccgtacg ccctgatcgg gcagctcatc      240

gacaacccgg cggtcgcctc ccagctgccg gatccggtct ccatggccct cccgggcgag      300

cacctgtcgc cggaggccga gaaccggctg cgcggcgacc tcacccgtac cctgctggcg      360

ctcgccgccg aacggccggt gctgatcggc atcgacgaca tgcaccacgc cgacaccgcc      420

tctttgaact gcctgctcca cctggcccgg agggtcggcc cggcccggat cgccatggtc      480

ctcaccgagc tgcgccggct caccccggcc cactcccagt tccacgccga gctgctcagc      540

ctggggcacc accgcgagat cgcgctgcgc ccgctcggcc cgaagcacat cgccgagctg      600

gcccgcgccg gcctcggtcc cgatgtcgac gaggacgtgc tcacggggtt gtaccgggcg      660

accggcggca acctgaacct cggccacgga ctgatcaagg atgtgcggga ggcctgggcg      720

acgggcggga cgggcatcaa cgcgggccgc gcgtaccggc tggcgtacct cggttccctc      780

taccgctgcg gcccggtccc gttgcgggtc gcacgggtgg ccgccgtgct gggccagagc      840

gccaacacca ccctggtgcg ctggatcagc gggctcaacg cggacgcggt gggcgaggcg      900

accgagatcc tcaccgaggg cggcctgctg cacgacctgc ggttcccgca tccggcggcc      960

cgttcggtcg tactcaacga cctgtccgcc cgggaacgcc gccgactgca ccggtccgct     1020

ctggaagtgc tggatgacgt acccgttgaa gtggtcgcgc accaccaggc cggtgccggt     1080

ttcatccacg gtcccaaggc cgccgagatc ttcgccaagg ccggccagga gctgcatgtg     1140

cgcggcgagc tggacgccgc gtccgactat ctgcaactgg cccaccacgc ctccgacgac     1200

gccgtcaccc gggccgcgct gcgggtcgag gccgtggcga tcgagcgccg ccgcaacccg     1260

ctggcctcca gccgccacct cgacgagctg accgtcgccg cccgtgccgg tctgctctcc     1320

ctcgagcacg ccgcgctgat gatccgctgg ctggctctcg gcgggcggtc cggcgaggcg     1380

gccgaggtgc tggccgcgca gcgcccgcgt gcggtcaccg accaggacag ggcccacctg     1440

cgggccgccg aggtatcgct ggcgctggtc agcccgggcg cgtccggcgt cagcccgggt     1500

gcgtccggcc cggatcggcg gccgcgtccg ctcccgccgg atgagctcgc gaacctgccg     1560

aaggcggccc ggctttgtgc gatcgccgac aacgccgtca tatcggccct gcacggtcgt     1620

cccgagcttg cctcggccga ggcggagaac gtcctgaagc aggctgactc ggcggcggac     1680

ggcgccaccg ccctctccgc gctgacggcc ttgctgtacg cggagaacac cgacaccgct     1740

cagctctggg ccgacaagct cgtctccgag accggggcgt cgaacgagga ggaaggcgcg     1800

ggctacgcgg ggccgcgcgc cgagaccgcg ttgcgccgcg gcgacctggc cgcggcggtc     1860

gaggcgggca gcgccattct ggaccaccgg cgggggtcgt tgctcggcat caccgccgcg     1920

ctaccgctga gcagcgcggt agccgccgcc atccggctgg gcgagaccga gcgggcggag     1980

aagtggctcg ccgagccgct gccggaggcc attcgggaca gcctgttcgg gctgcacctg     2040

ctctcggcgc gcggccagta ctgcctcgcg acgggccggc acgagtcggc gtacacggcg     2100

ttccgcacct gcggggaacg gatgcggaac tggggcgtcg acgtgccggg tctgtccctg     2160

tggcgcgtcg acgccgccga ggcgctgctg cacggccgcg accgggacga gggccgacgg     2220

ctcatcgacg agcagctcac ccatgcgatg ggaccccgtt cccgcgcttt gacgctgcgg     2280

gtgcaggcgg cgtacagccc gcaggcgcag cgggtcgacc tgctcgaaga ggcggccgac     2340

ctgctgctct cctgcaacga ccagtacgag cgggcgcggg tgctcgccga tctgagcgag     2400

gcgttcagcg cgctcaggca ccacagccgg gcgcggggac tgctccggca ggcccggcac     2460

ctggccgccc agtgcggcgc gaccccgctg ctgcgccggc tcggggccaa gcccggaggc     2520

cccggctggc tggaggaatc cggcctgccg cagcggatca agtcgctgac cgacgcggag     2580

cggcgggtgg cgtcgctggc cgccggcggc cagaccaacc gcgtgatcgc cgaccagctc     2640

ttcgtcacgg ccagcacggt ggagcagcac ctcacgaacg tcttccgcaa gctgggcgtc     2700

aagggccgcc agcacctgcc ggccgaactc gccaacgcgg aatag                     2745


<210>  183
<211>  2619
<212>  DNA
<213>  Actinoplanes sp. N01-109

<400>  183
gtgaagcgca acgatctggt tgcccgcgat ggcgagctca ggtggatgca agagattctc       60

agtcaggcga gcgagggccg gggggccgtg gtcaccatca cgggggcgat cgcctgtggc      120

aagacggtgc tgctggacgc cgcggcagcc agtcaagacg tgatccaact gcgtgcggtc      180

tgctcggcgg aggagcagga gctgccgtac gcgatggtcg gacaactact cgacaatccg      240

gtgctcgccg cgcgagtgcc ggccctgggc aacctggctg cggcgggcga gcggctgctg      300

ccgggcaccg agaacaggat ccggcgggag ctcacccgca ccctgctggc tctcgccgac      360

gaacgaccgg tgctgatcgg cgtcgacgac atgcaccatg cggaccccgc ctcgctggac      420

tgcctgctgc acctggcccg gcgggtcggc ccggcccgca tcgcgatcgt tctgaccgag      480

ttgcgccggc tcaccccggc tcactcgcgc ttccagtccg agctgctcag cctgcggtac      540

caccacgaga tcgggttgca gccgctcacc gcggagcaca ccgccgacct ggcccgcgtc      600

ggcctcggtg ccgaggtcga cgacgacgtg ctcaccgagc tctacgaggc gaccggcggc      660

aacccgagtc tgtgctgcgg cctgatcagg gacgtgcggc aggactggga ggccggggtc      720

accggtatcc acgtcggccg ggcgtaccgg ctggcctatc tcagttcgct ctaccgctgc      780

ggcccggcgg cgctgcggac cgcccgcgcg gccgcggtgc tgggcgacag cgccgacgcc      840

tgcctgatcc gccgggtcag cggcctcggt acggaggccg tgggccaggc gatccagcag      900

ctcaccgagg gcggcctgct gcgtgaccag cagttcccgc acccggcggc ccgctcggtc      960

gtgctcgacg acatgtccgc gcaggaacgc cacgcgatgt atcgcagcgc ccgggaggca     1020

gccgccgaag gtcaggccga ccccggcacc ccgggcgagc cgcgggcggc tacggcgtac     1080

gccgggtgtg gtgagcaagc cggtgactac ccggagccgg ccggccgggc ctgcgtggac     1140

ggtgccggtc cggccgagta ctgcggcgac ccgcacggcg ccgacgacga cccggacgag     1200

ctggtcgccg cgctgggcgg gctgctgccg agccggctcg tggcgatgaa gatccggcgc     1260

ctggcggtgg ccgggcgccc cggggcggct gccgagctgc tgacctcgca gcggttgcac     1320

gcggtgacca gcgaggaccg ggccagcctg cgggccgccg aggtggcgct cgccacgctg     1380

tggccgggtg cgaccggccc ggaccggcat ccgctcacgg agcaggaggc ggcgagcctg     1440

ccggagggtc cgcgcctgct cgctgccgcc gacgatgccg tcggggccgc cctgcgcggt     1500

cgcgccgagt acgccgcggc cgaggcggag aacgtcctgc ggcacgccga tccggcagcc     1560

ggtggtgacg cctacgccgc catgatcgcc ctgctgtaca cggagcaccc cgagaacgtg     1620

ctgttctggg ccgacaagct cgacgcgggc cgccccgacg aggagaccag ttatcccggg     1680

ctgcgggccg agaccgcggt gcggctcggt gacctggaaa cggcgatgga gctgggccgc     1740

acggtgctgg accagcggcg gctgccgtcc ctgggtgtcg ccgcgggcct gctcctgggc     1800

ggcgcggtga cggccgccat ccggctcggc gacctcgacc gggcggagaa gtggctcgcc     1860

gagccgatcc ccgacgccat ccgtaccagc ctctacggcc tgcacgtgct ggccgcgcgg     1920

ggccggctcg acctggccgc gggccgctac gaggcggcgt acacggcgtt ccggctgtgt     1980

ggcgagcgga tggcaggctg ggatgccgat gtctccgggc tggcgctgtg gcgcgtcgac     2040

gccgccgagg ccctgctgtc cgcgggcatc cgcccggacg agggccgcaa gctcatcgac     2100

gaccagctca cccgtgagat gggggcccgc tcccgggcgc tgacgctgcg ggcgcaagcg     2160

gcgtacagcc tgccggtgca ccgggtgggc ctgctcgacg aggcggccgg cctgctgctc     2220

gcctgccatg acgggtacga gcgggcgcgg gtgctcgcgg acctggggga gaccctgcgc     2280

acgctgcggc acaccgacgc ggcccagcgg gtgctccggc aggccgagca ggcggccgcg     2340

cggtgcgggt cggtcccgct gctgcggcgg ctcggggccg aacccgtacg catcggcacc     2400

cggcgtggtg aacccggcct gccgcagcgg atcaggctgc tgaccgatgc cgagcggcgg     2460

gttgccgcga tggccgccgc cgggcagacc aaccgggaga tcgccggtcg gctcttcgtc     2520

acggccagca cggtggagca gcacctgacc agcgtcttcc gcaagctggg cgtcaagggc     2580

cgccggttcc tgccgaccga gctcgcccaa gccgtctga                            2619


<210>  184
<211>  2628
<212>  DNA
<213>  Actinoplanes sp. N01-109

<400>  184
atgcctgccg tgaagcgcaa cgatctggtt gcccgcgatg gcgagctcag gtggatgcaa       60

gagattctca gtcaggcgag cgagggccgg ggggccgtgg tcaccatcac gggggcgatc      120

gcctgtggca agacggtgct gctggacgcc gcggcagcca gtcaagacgt gatccaactg      180

cgtgcggtct gctcggcgga ggagcaggag ctgccgtacg cgatggtcgg acaactactc      240

gacaatccgg tgctcgccgc gcgagtgccg gccctgggca acctggctgc ggcgggcgag      300

cggctgctgc cgggcaccga gaacaggatc cggcgggagc tcacccgcac cctgctggct      360

ctcgccgacg aacgaccggt gctgatcggc gtcgacgaca tgcaccatgc ggaccccgcc      420

tcgctggact gcctgctgca cctggcccgg cgggtcggcc cggcccgcat cgcgatcgtt      480

ctgaccgagt tgcgccggct caccccggct cactcgcgct tccagtccga gctgctcagc      540

ctgcggtacc accacgagat cgggttgcag ccgctcaccg cggagcacac cgccgacctg      600

gcccgcgtcg gcctcggtgc cgaggtcgac gacgacgtgc tcaccgagct ctacgaggcg      660

accggcggca acccgagtct gtgctgcggc ctgatcaggg acgtgcggca ggactgggag      720

gccggggtca ccggtatcca cgtcggccgg gcgtaccggc tggcctatct cagttcgctc      780

taccgctgcg gcccggcggc gctgcggacc gcccgcgcgg ccgcggtgct gggcgacagc      840

gccgacgcct gcctgatccg ccgggtcagc ggcctcggta cggaggccgt gggccaggcg      900

atccagcagc tcaccgaggg cggcctgctg cgtgaccagc agttcccgca cccggcggcc      960

cgctcggtcg tgctcgacga catgtccgcg caggaacgcc acgcgatgta tcgcagcgcc     1020

cgggaggcag ccgccgaagg tcaggccgac cccggcaccc cgggcgagcc gcgggcggct     1080

acggcgtacg ccgggtgtgg tgagcaagcc ggtgactacc cggagccggc cggccgggcc     1140

tgcgtggacg gtgccggtcc ggccgagtac tgcggcgacc cgcacggcgc cgacgacgac     1200

ccggacgagc tggtcgccgc gctgggcggg ctgctgccga gccggctcgt ggcgatgaag     1260

atccggcgcc tggcggtggc cgggcgcccc ggggcggctg ccgagctgct gacctcgcag     1320

cggttgcacg cggtgaccag cgaggaccgg gccagcctgc gggccgccga ggtggcgctc     1380

gccacgctgt ggccgggtgc gaccggcccg gaccggcatc cgctcacgga gcaggaggcg     1440

gcgagcctgc cggagggtcc gcgcctgctc gctgccgccg acgatgccgt cggggccgcc     1500

ctgcgcggtc gcgccgagta cgccgcggcc gaggcggaga acgtcctgcg gcacgccgat     1560

ccggcagccg gtggtgacgc ctacgccgcc atgatcgccc tgctgtacac ggagcacccc     1620

gagaacgtgc tgttctgggc cgacaagctc gacgcgggcc gccccgacga ggagaccagt     1680

tatcccgggc tgcgggccga gaccgcggtg cggctcggtg acctggaaac ggcgatggag     1740

ctgggccgca cggtgctgga ccagcggcgg ctgccgtccc tgggtgtcgc cgcgggcctg     1800

ctcctgggcg gcgcggtgac ggccgccatc cggctcggcg acctcgaccg ggcggagaag     1860

tggctcgccg agccgatccc cgacgccatc cgtaccagcc tctacggcct gcacgtgctg     1920

gccgcgcggg gccggctcga cctggccgcg ggccgctacg aggcggcgta cacggcgttc     1980

cggctgtgtg gcgagcggat ggcaggctgg gatgccgatg tctccgggct ggcgctgtgg     2040

cgcgtcgacg ccgccgaggc cctgctgtcc gcgggcatcc gcccggacga gggccgcaag     2100

ctcatcgacg accagctcac ccgtgagatg ggggcccgct cccgggcgct gacgctgcgg     2160

gcgcaagcgg cgtacagcct gccggtgcac cgggtgggcc tgctcgacga ggcggccggc     2220

ctgctgctcg cctgccatga cgggtacgag cgggcgcggg tgctcgcgga cctgggggag     2280

accctgcgca cgctgcggca caccgacgcg gcccagcggg tgctccggca ggccgagcag     2340

gcggccgcgc ggtgcgggtc ggtcccgctg ctgcggcggc tcggggccga acccgtacgc     2400

atcggcaccc ggcgtggtga acccggcctg ccgcagcgga tcaggctgct gaccgatgcc     2460

gagcggcggg ttgccgcgat ggccgccgcc gggcagacca accgggagat cgccggtcgg     2520

ctcttcgtca cggccagcac ggtggagcag cacctgacca gcgtcttccg caagctgggc     2580

gtcaagggcc gccggttcct gccgaccgag ctcgcccaag ccgtctga                  2628


<210>  185
<211>  2616
<212>  DNA
<213>  Streptomyces malaysiensis

<400>  185
gtggtcaccg tcaccggccc aatcgcctgc ggcaagacag aactgcttga cgcggctgcc       60

gcgaaggctg aggccatcat tctgcgcgcg gtctgcgcgc cagaagagcg ggctatgccg      120

tacgccatga tcgggcagct catcgacgac ccggcgctcg cgcatcgggc gccggggctg      180

gctgatcgga tagcccaggg cgggcagctg tcgctgaggg ccgagaaccg actgcgcagg      240

gatctcaccc gtgccctgct ggcgcttgcc gtggaccggc ctgtgctgat cggcgtcgac      300

gatgtgcatc acgccgacac cgcctctttg aactgtctgc tgcatttggc ccgccgggtc      360

cgtccggccc ggatatccat gatcttcacc gagttgcgca gcctcacccc tactcagtca      420

cggttcaagg cggagctgct cagcctgcca taccaccacg agatcgcgct gcgtccattc      480

ggaccggagc aatcggcgga gctggctcgc gccgccttcg gcccgggcct cgccgaggat      540

gtgctcgcgg ggttgtataa aacgaccagg ggcaatctga gtctcagccg tggactgatc      600

agcgatgtgc gggaggccct ggccaacgga gagagcgctt tcgaggcggg ccgcgcgttc      660

cggctggcgt acctcagctc gctctaccgc tgtggcccgg tcgcgctgcg ggtcgcccga      720

gtggctgccg tgctgggccc aagcgccacc accacgctgg tgcgccggct aagcgggctc      780

agcgcggaga cgatagaccg ggcaaccaag atcctcactg agggcgggct gctgctcgac      840

cagcagttcc cgcacccggc cgcccgctcg gtggtgctcg atgacatgtc cgcccaggaa      900

cgacgcagcc tgcacactct cgccctggaa ctgctggacg aggcgccggt tgaagtgctc      960

gcgcaccacc aggtcggcgc cggtctcata cacgggccca aggctgcgga gatgttcgcc     1020

aaggccggca aggctctggt cgtacgcaac gagttgggcg acgcggccga atacctgcaa     1080

ctggctcacc gggcctccga cgatgtctcc acccgggccg ccttacgggt cgaggccgtg     1140

gccatcgagc gccgccgcaa tccgctggcc tccagtcggc acatggacga actgagcgcc     1200

gccggccgcg ccggtctgct ttcccccaag catgcggcgc tggccgtctt ctggctagcc     1260

gacggcgggc gatccggcga ggcagccgaa gtgctggcgt cggaacgccc gctcgcgacc     1320

accgatcaga accgggccca cctgcgattt gtcgaggtga ctctcgcgct gttctctccc     1380

ggcgccttcg gatcggaccg gcgcccacct ccgctgacgc cggacgaact cgccagcctg     1440

ccgaaggcgg cctggcaatg cgcggtcgcc gacaacgcgg ccatgaccgc cttgcacggc     1500

catccagaac ttgccaccgc tcaggcggaa acagttctgc ggcaggctga ttcggcagcc     1560

gacgcgatcc ccgccgcgct gatcgccctg ttgtacgcgg agaacaccga gtccgctcat     1620

atctgggccg acaagctggg cagcacgaat gccggggtat cgaacgaggc ggaagcgggc     1680

tacgccggcc cgtgcgccga gatcgccctg cggcgcggcg acctggccac ggcgttcgag     1740

gctggtagcg ccgtcctgga cgaccggtcg ctgccgtcgc tcggcatcac cgccgcattg     1800

ctgttgagca gcaagacggc cgccgctgtc cggctgggcg aactcgagcg tgcggagaag     1860

ctgctcgccg agccgcttcc gaacggcgtc caggacagcc ttttcggtct gcacctgctc     1920

tcggcgtacg gccagtacag cctcgcgatg ggccgatatg aatcagctca ccgggcgttt     1980

cgcacctgcg gagaacgtat gcgcagctgg gatgttgacg tgcctggtct ggccctgtgg     2040

cgtgtcgacg ccgccgaggc gctgctcagc ctcgaccgga acgagggcca gcggctcatc     2100

gacgaacaac tcacccgtcc gatggggcct cgttcccacg cgttaacgct gcggatcaag     2160

gcggcatacc tcccgcggac gaagcggatc cccctgctcc atgaggcggc cgagctgctg     2220

ctcccctgcc ccgacccgta cgagcaagcg cgggtgctcg ccgatctggg cgacacgctc     2280

agcgcgctca gacgctatag ccgggcgcgg ggagttctcc ggcaggctcg tcacctggcc     2340

acccagtgcg gtgctgtccc gctgctgcgc aggctcgggg gcgagcccgg ccggatcgac     2400

gacgccggcc tgccgcagcg gagcacatcg ttgaccgatg cggagcggcg ggtggcggcg     2460

ctggccgcgg ccggacagac caaccgggag atcgccgaac agctgttcgt cacggccagc     2520

acagtggaac agcacctcac aagcgtcttc cgcaagctgg gcgtcaaggg ccgcaagcag     2580

ctgccgaccg cgctggccga cgtggaacag acctga                               2616


<210>  186
<211>  2721
<212>  DNA
<213>  Streptomyces malaysiensis

<400>  186
atgtatagcg gtacctgccg tgaaggatac gaactcgtcg cacgcgagga cgaactcggt       60

attctacaga ggtctctgga acaagcgagc agcggccagg gcgtcgtggt caccgtcacc      120

ggcccaatcg cctgcggcaa gacagaactg cttgacgcgg ctgccgcgaa ggctgaggcc      180

atcattctgc gcgcggtctg cgcgccagaa gagcgggcta tgccgtacgc catgatcggg      240

cagctcatcg acgacccggc gctcgcgcat cgggcgccgg ggctggctga tcggatagcc      300

cagggcgggc agctgtcgct gagggccgag aaccgactgc gcagggatct cacccgtgcc      360

ctgctggcgc ttgccgtgga ccggcctgtg ctgatcggcg tcgacgatgt gcatcacgcc      420

gacaccgcct ctttgaactg tctgctgcat ttggcccgcc gggtccgtcc ggcccggata      480

tccatgatct tcaccgagtt gcgcagcctc acccctactc agtcacggtt caaggcggag      540

ctgctcagcc tgccatacca ccacgagatc gcgctgcgtc cattcggacc ggagcaatcg      600

gcggagctgg ctcgcgccgc cttcggcccg ggcctcgccg aggatgtgct cgcggggttg      660

tataaaacga ccaggggcaa tctgagtctc agccgtggac tgatcagcga tgtgcgggag      720

gccctggcca acggagagag cgctttcgag gcgggccgcg cgttccggct ggcgtacctc      780

agctcgctct accgctgtgg cccggtcgcg ctgcgggtcg cccgagtggc tgccgtgctg      840

ggcccaagcg ccaccaccac gctggtgcgc cggctaagcg ggctcagcgc ggagacgata      900

gaccgggcaa ccaagatcct cactgagggc gggctgctgc tcgaccagca gttcccgcac      960

ccggccgccc gctcggtggt gctcgatgac atgtccgccc aggaacgacg cagcctgcac     1020

actctcgccc tggaactgct ggacgaggcg ccggttgaag tgctcgcgca ccaccaggtc     1080

ggcgccggtc tcatacacgg gcccaaggct gcggagatgt tcgccaaggc cggcaaggct     1140

ctggtcgtac gcaacgagtt gggcgacgcg gccgaatacc tgcaactggc tcaccgggcc     1200

tccgacgatg tctccacccg ggccgccctg cgggtcgagg ccgtggccat cgagcgccgc     1260

cgcaatccgc tggcctccag tcggcacatg gacgaactga gcgccgccgg ccgcgccggt     1320

ctgctttccc ccaagcatgc ggcgctggcc gtcttctggc tagccgacgg cgggcgatcc     1380

ggcgaggcag ccgaagtgct ggcgtcggaa cgcccgctcg cgaccaccga tcagaaccgg     1440

gcccacctgc gatttgtcga ggtgactctc gcgctgttct ctcccggcgc cttcggatcg     1500

gaccggcgcc cacctccgct gacgccggac gaactcgcca gcctgccgaa ggcggcctgg     1560

caatgcgcgg tcgccgacaa cgcggccatg accgccttgc acggccatcc agaacttgcc     1620

accgctcagg cggaaacagt tctgcggcag gctgattcgg cagccgacgc gatccccgcc     1680

gcgctgatcg ccctgttgta cgcggagaac accgagtccg ctcatatctg ggccgacaag     1740

ctgggcagca cgaatgccgg ggtatcgaac gaggcggaag cgggctacgc cggcccgtgc     1800

gccgagatcg ccctgcggcg cggcgacctg gccacggcgt tcgaggctgg tagcgccgtc     1860

ctggacgacc ggtcgctgcc gtcgctcggc atcaccgccg cattgctgtt gagcagcaag     1920

acggccgccg ctgtccggct gggcgaactc gagcgtgcgg agaagctgct cgccgagccg     1980

cttccgaacg gcgtccagga cagccttttc ggtctgcacc tgctctcggc gtacggccag     2040

tacagcctcg cgatgggccg atatgaatca gctcaccggg cgtttcgcac ctgcggagaa     2100

cgtatgcgca gctgggatgt tgacgtgcct ggtctggccc tgtggcgtgt cgacgccgcc     2160

gaggcgctgc tcagcctcga ccggaacgag ggccagcggc tcatcgacga acaactcacc     2220

cgtccgatgg ggcctcgttc ccacgcgctg acgctgcgga tcaaggcggc atacctcccg     2280

cggacgaagc ggatccccct gctccatgag gcggccgagc tgctgctccc ctgccccgac     2340

ccgtacgagc aagcgcgggt gctcgccgat ctgggcgaca cgctcagcgc gctcagacgc     2400

tatagccggg cgcggggagt tctccggcag gctcgtcacc tggccaccca gtgcggtgct     2460

gtcccgctgc tgcgcaggct cgggggcgag cccggccgga tcgacgacgc cggcctgccg     2520

cagcggagca catcgttgac cgatgcggag cggcgggtgg cggcgctggc cgcggccgga     2580

cagaccaacc gggagatcgc cgaacagctg ttcgtcacgg ccagcacagt ggaacagcac     2640

ctcacaagcg tcttccgcaa gctgggcgtc aagggccgca agcagctgcc gaccgcgctg     2700

gccgacgtgg aacagacctg a                                               2721


<210>  187
<211>  2715
<212>  DNA
<213>  Streptomyces violaceusniger

<400>  187
gtgtatagcg gtacctgccg tgaaggatac gaactcgtcg cccgcgagga cgaactcggc       60

attctgcaga ggtctctgga agaagcaggc agcggccagg gcgccgtggt caccgtcacc      120

ggcccgatcg cctgcggcaa gacagaactg cttgacgcgg ctgccgcgaa ggctgacgcc      180

atcattctgc gcgcggtctg cgcgcccgaa gagcgcgcta tgccgtacgc catgatcggg      240

cagctcatcg acgacccggc gctcgcgcat cgggcgccgg agctggctga tcggatagcc      300

cagggcgggc atctgtcgct gagggccgag aaccgactgc gcagggatct cacccgtgcc      360

ctgctggcgc ttgccgtcga ccggcctgtg ctgatcggcg tcgacgatgt gcatcacgcc      420

gacaccgcct ctttgaactg tctgctgcat ttagcccgcc gggtccgtcc ggcccggata      480

tccatgatct tcaccgagtt gcgcagcctc acccctactc agtcacgatt caaggcggag      540

ctgctcagcc tgccgtacca ccacgagatc gcgctgcgtc cactcggacc ggagcaatcg      600

gcggagctgg cccacgccgc cttcggcccg ggcctcgccg aggatgtgct cgcggggttg      660

tatgggatga ccaggggcaa cctgagtctc agccgtggac tgatcagcga tgtgcgggag      720

gcccaggcca acggagagag cgctttcgag gtgggccgcg cgttccggct ggcgtacctc      780

agctcgctct accgctgtgg cccgatcgcg ctgcgggtcg cccgagtggc tgccgtgctg      840

ggcccaagcg ccaccaccac gctggtgcgc cgtctaagcg ggctcagcgc ggagacgata      900

gaccgggcaa ccaagatcct cactgagggc gggctgctgc tcgaccacca gttcccgcac      960

ccggccgccc gctcggtggt gctcgatgac atgtccgccc aggaacgacg cagcctgcac     1020

actctcgccc tggaactgct ggacgaggcg ccggttgaag tgctcgcgca ccaccaggtc     1080

ggcgccggtc tcatacacgg gcccaaggct gcggagatat tcgccagggc tggccaggct     1140

ctggttgtac gcaacgagtt gggcgacgcg gccgaatacc tgcaactggc tcaccgagcc     1200

tccgacgatg tctccacccg ggccgcctta cgggtcgagg ccgtggcaat cgagcgccgc     1260

cgcaatccgc tggcctccag tcgtcacatg gacgagctga gcgccgccgg ccgcgccggt     1320

ctgctttccc ccaagcatgc agcgctggct gtcttctggc tggccgacgg cgggcgatcc     1380

ggcgaggcag ccgaggtgct ggcgtcggaa cacccgctcg cgaccaccga tcagaaccga     1440

gcacacctgc gatttgccga ggtgactctc gcgctgttct gtcccggcgc cttcgggtcg     1500

gaccggcgcc cacctccgct ggcgccggac gagctcgcca gcttgccgaa ggcggcctgg     1560

caatgcgcgg tcgccgacaa cgcggtcatg acagcgttgc atgctcatcc agaacttgcc     1620

accgctcagg cggaaacagt tctgcggcag gctgattcgg cagccgacgc aatccccgcc     1680

gcactgatcg ccctgttgta cgcagagaac accgagtccg ctcagatctg ggccgacaag     1740

ctgggcagca ccaatgccgg ggtatcgaac gaggcggaag cgggctacgc cggcccgtgc     1800

gccgagatcg ccctgcggcg cggcgacctg gccacggcgt tcgaggctgg tggcaccgtc     1860

ctggacgacc ggccgctgcc gtcgctcggc atcaccgccg cattgctgtt gagcagcaag     1920

acggcagccg ctgtccgcct gggcgaactc gagcgtgcgg agaagctgct cgctgagccg     1980

cttccgaacg gtgtccagga cagccttttc ggtctgcacc tgctctcggc gcacggccag     2040

tacagcctcg cgatgggccg atatgaatcg gctcaccggg cgtttcacac ctgcggagaa     2100

cgtatgcgca gctggggtgt tgacgtgcct ggtctagccc tgtggcgtgt cgacgccgcc     2160

gaggcactgc tcagcctcga ccggaacgag ggccagcggc tcatcgacga acaactcgcc     2220

cgtccgatgg gacctcgttc ccgcgcatta acgctgcgga tcaaggcggc atacctcccg     2280

cggacgaagc ggatccccct gctccatgag gcagctgagc tgctgctctc ctgccccgac     2340

ccgtacgagc aagcgcgggt gctcgccgat ctgggcgaca cgctcagcgc gctcagacgc     2400

tatagccggg cgcggggagt tctccggcag gctcgtcacc tggccaccca gtgcggtgct     2460

gtcccgctgc tgcgccgact cgggggcgag cccggccgga tcgacgacgc cggcctgccg     2520

cagcggagca catcgttgac cgatgcggag cggcgggtgt cggccctggc cgcggccgga     2580

cagaccaacc gggagatcgc caaacagcta ttcgtcacgg ccagcaccgt ggaacagcac     2640

ctcacaagcg tcttccgcaa gctgggcgtt aagggccgca ggcagctacc gaccgcgctg     2700

gccgacgtgg aatag                                                      2715


<210>  188
<211>  2715
<212>  DNA
<213>  Streptomyces violaceusniger

<400>  188
atgtatagcg gtacctgccg tgaaggatac gaactcgtcg cccgcgagga cgaactcggc       60

attctgcaga ggtctctgga agaagcaggc agcggccagg gcgccgtggt caccgtcacc      120

ggcccgatcg cctgcggcaa gacagaactg cttgacgcgg ctgccgcgaa ggctgacgcc      180

atcattctgc gcgcggtctg cgcgcccgaa gagcgcgcta tgccgtacgc catgatcggg      240

cagctcatcg acgacccggc gctcgcgcat cgggcgccgg agctggctga tcggatagcc      300

cagggcgggc atctgtcgct gagggccgag aaccgactgc gcagggatct cacccgtgcc      360

ctgctggcgc ttgccgtcga ccggcctgtg ctgatcggcg tcgacgatgt gcatcacgcc      420

gacaccgcct ctttgaactg tctgctgcat ctggcccgcc gggtccgtcc ggcccggata      480

tccatgatct tcaccgagtt gcgcagcctc acccctactc agtcacgatt caaggcggag      540

ctgctcagcc tgccgtacca ccacgagatc gcgctgcgtc cactcggacc ggagcaatcg      600

gcggagctgg cccacgccgc cttcggcccg ggcctcgccg aggatgtgct cgcggggttg      660

tatgggatga ccaggggcaa cctgagtctc agccgtggac tgatcagcga tgtgcgggag      720

gcccaggcca acggagagag cgctttcgag gtgggccgcg cgttccggct ggcgtacctc      780

agctcgctct accgctgtgg cccgatcgcg ctgcgggtcg cccgagtggc tgccgtgctg      840

ggcccaagcg ccaccaccac gctggtgcgc cgtctaagcg ggctcagcgc ggagacgata      900

gaccgggcaa ccaagatcct cactgagggc gggctgctgc tcgaccacca gttcccgcac      960

ccggccgccc gctcggtggt gctcgatgac atgtccgccc aggaacgacg cagcctgcac     1020

actctcgccc tggaactgct ggacgaggcg ccggttgaag tgctcgcgca ccaccaggtc     1080

ggcgccggtc tcatacacgg gcccaaggct gcggagatat tcgccagggc tggccaggct     1140

ctggttgtac gcaacgagtt gggcgacgcg gccgaatacc tgcaactggc tcaccgagcc     1200

tccgacgatg tctccacccg ggccgccctg cgggtcgagg ccgtggcaat cgagcgccgc     1260

cgcaatccgc tggcctccag tcgtcacatg gacgagctga gcgccgccgg ccgcgccggt     1320

ctgctttccc ccaagcatgc agcgctggct gtcttctggc tggccgacgg cgggcgatcc     1380

ggcgaggcag ccgaggtgct ggcgtcggaa cacccgctcg cgaccaccga tcagaaccga     1440

gcacacctgc gatttgccga ggtgactctc gcgctgttct gtcccggcgc cttcgggtcg     1500

gaccggcgcc cacctccgct ggcgccggac gagctcgcca gcttgccgaa ggcggcctgg     1560

caatgcgcgg tcgccgacaa cgcggtcatg acagcgttgc atgctcatcc agaacttgcc     1620

accgctcagg cggaaacagt tctgcggcag gctgattcgg cagccgacgc aatccccgcc     1680

gcactgatcg ccctgttgta cgcagagaac accgagtccg ctcagatctg ggccgacaag     1740

ctgggcagca ccaatgccgg ggtatcgaac gaggcggaag cgggctacgc cggcccgtgc     1800

gccgagatcg ccctgcggcg cggcgacctg gccacggcgt tcgaggctgg tggcaccgtc     1860

ctggacgacc ggccgctgcc gtcgctcggc atcaccgccg cattgctgtt gagcagcaag     1920

acggcagccg ctgtccgcct gggcgaactc gagcgtgcgg agaagctgct cgctgagccg     1980

cttccgaacg gtgtccagga cagccttttc ggtctgcacc tgctctcggc gcacggccag     2040

tacagcctcg cgatgggccg atatgaatcg gctcaccggg cgtttcacac ctgcggagaa     2100

cgtatgcgca gctggggtgt tgacgtgcct ggtctagccc tgtggcgtgt cgacgccgcc     2160

gaggcactgc tcagcctcga ccggaacgag ggccagcggc tcatcgacga acaactcgcc     2220

cgtccgatgg gacctcgttc ccgcgcactg acgctgcgga tcaaggcggc atacctcccg     2280

cggacgaagc ggatccccct gctccatgag gcagctgagc tgctgctctc ctgccccgac     2340

ccgtacgagc aagcgcgggt gctcgccgat ctgggcgaca cgctcagcgc gctcagacgc     2400

tatagccggg cgcggggagt tctccggcag gctcgtcacc tggccaccca gtgcggtgct     2460

gtcccgctgc tgcgccgact cgggggcgag cccggccgga tcgacgacgc cggcctgccg     2520

cagcggagca catcgttgac cgatgcggag cggcgggtgt cggccctggc cgcggccgga     2580

cagaccaacc gggagatcgc caaacagcta ttcgtcacgg ccagcaccgt ggaacagcac     2640

ctcacaagcg tcttccgcaa gctgggcgtt aagggccgca ggcagctacc gaccgcgctg     2700

gccgacgtgg aatag                                                      2715


<210>  189
<211>  2721
<212>  DNA
<213>  Streptomyces Sp. NRRL F-4729

<400>  189
gtgtatagcg gtacctgccg tgaaggatac gaactcgtcg cacgcgagga cgaactcggc       60

attctacaga ggtctctgga acaagcgagc agcggccagg gcgtcgtggt caccgtcacc      120

ggcccaatcg cctgcggcaa gacagaactg cttgacgcgg ctgccgcgaa ggctgaggcc      180

atcattctgc gcgcggtctg cgcgcccgaa gagcgggcta tgccgtacgc catgatcggg      240

cagctcatcg acgacccggc gctcgcgcat cgggcgccgg ggctggctga tcggatagcc      300

cagggcgggc agctgtcgct gagggccgag aaccgactgc gcagggatct cacccgtgcc      360

ctgctggcgc ttgccgtgca ccggcctgtg ctgatcggcg tcgatgatgt gcatcacgcc      420

gacaccgcct ctttgaactg tctgctgcat ttggcgcgcc gggtccgtcc ggcccggata      480

tccatgatct tcaccgagtt gcgcagcctc acccctactc agtcacgatt caaggcggag      540

ctgctcagcc tgccgtacca ccacgagatc gcgctgcgtc cattcggacc ggagcaatcg      600

gcggagctgg ctcgcgccgc cttcggcccg ggcctcgccg aggatgtgct cgcggggttg      660

tataaaacga ccaggggcaa tctgagtctc agccgtggac tgatcagcga tgtgcgggag      720

gccctggcca acggagagag cgctttcgag gcgggccgcg cgttccggct ggcgtacctc      780

agctcgctct accgctgtgg cccggtcgcg ctgcgggtcg cccgagtggc tgccgtgctg      840

ggcccaagcg ccaccaccac gctggtgcgc cggctaagcg ggctcagcgc ggagacgata      900

gaccgggcaa ccaagatcct caccgagggc gggctgctgc tcgaccagca gtttccgcac      960

ccggccgccc gctcggtggt gctcgatgac atgtccgccc aggaacgacg cggcctgcac     1020

actctcgccc tggaactgct ggacgaggcg ccggttgaag tgctcgcgca ccaccaggtc     1080

ggcgccggtc tcatacacgg gcccaaggct gcggagatgt tcgccaaggc cggcaaggct     1140

ctggtcgtac gcaacgagtt gggcgacgcg gccgaatacc tgcaactggc tcaccgggcc     1200

tccgacgatg tctccacccg ggccgcctta cgggtcgagg ccgtggcgat cgagcgccgc     1260

cgcaatccgc tggcctccag tcggcacatg gacgagctga gcgccgccgg ccgcgccggt     1320

ctgctttccc ccaagcatgc ggcgctggcc gtcttctggc tggccgacgg cgggcgatcc     1380

ggcgaggcag cccaggtgct ggcgtcggaa cgcccgctcg cgaccaccga tcagaaccgg     1440

gcccacctgc gatttgtcga ggtgactctc gcgctgttct ctcccggcgc cttcggatcg     1500

gaccggcgcc cacctccgct gacgccggac gaactcgcca gcctgccgaa ggcggcctgg     1560

caatgcgcgg tcgccgacaa cgcggccatg accgccttgc acggccatcc agaacttgcc     1620

accgctcagg cggaaacagt tctgcggcag gctgattcgg cagccgacgc gatccccgcc     1680

gcgctgatcg ccctgttgta cgcggagaac accgagtccg ctcatatctg ggccgacaag     1740

ctgggcagca tgaatgccgg ggtatcgaac gaggcggaag cgggctacgc cggcccgtgc     1800

gccgagatcg ccctgcggcg cggcgacctg gccacggcgt tcgaggctgg tagcaccgtc     1860

ctggacgacc ggtcactgcc gtcgctcggc atcaccgccg cattgctgtt gagcagcaag     1920

acggccgccg ctgtccggct gggcgaactc gagcgtgcgg agaagctgct cgccgagccg     1980

cttccgaacg gcgtccagga cagccttttc ggtctgcacc tgctctcggc gtacggccag     2040

tacagcctcg cgatgggccg atatgaatcg gctcaccggg cgtttcgcac ctgcggagaa     2100

cgtatgcgca gctgggatgt tgacgtgcct ggtctggccc tgtggcgtgt cgacgccgcc     2160

gaggcgctgc tcagcctcga ccggaacgag ggccagcggc tcatcgacga acaactcacc     2220

cgtccgatgg gacctcgttc ccgcgcgtta acgctgcgga tcaaggcggc atacctcccg     2280

cggacgaagc ggatccccct gctccatgag gcggccgagc tgctgctccc ctgccccgac     2340

ccgtacgagc aagcgcgggt gctcgccgat ctgggcgaca cgctcagcgc gctcagacgc     2400

tatagccggg cgcggggagt tctccggcag gctcgtcacc tggccaccca gtgcggtgct     2460

gtcccgctgc tgcgccgact cgggggcgag cccggccgga tcgacgacgc cggcctgccg     2520

cagcggagca catcgttgac cgatgcggag cggcgggtgg cggcgctggc cgcggccgga     2580

cagaccaacc gggagatcgc cgaacagctg ttcgtcacgg ccagcacagt ggaacagcac     2640

ctcacaagcg tcttccgcaa gctgggcgtc aagggccgca agcagctgcc gaccgcgctg     2700

gccgacgtgg aacagacctg a                                               2721


<210>  190
<211>  2721
<212>  DNA
<213>  Streptomyces Sp. NRRL F-4729

<400>  190
atgtatagcg gtacctgccg tgaaggatac gaactcgtcg cacgcgagga cgaactcggc       60

attctacaga ggtctctgga acaagcgagc agcggccagg gcgtcgtggt caccgtcacc      120

ggcccaatcg cctgcggcaa gacagaactg cttgacgcgg ctgccgcgaa ggctgaggcc      180

atcattctgc gcgcggtctg cgcgcccgaa gagcgggcta tgccgtacgc catgatcggg      240

cagctcatcg acgacccggc gctcgcgcat cgggcgccgg ggctggctga tcggatagcc      300

cagggcgggc agctgtcgct gagggccgag aaccgactgc gcagggatct cacccgtgcc      360

ctgctggcgc ttgccgtgca ccggcctgtg ctgatcggcg tcgatgatgt gcatcacgcc      420

gacaccgcct ctttgaactg tctgctgcat ttggcgcgcc gggtccgtcc ggcccggata      480

tccatgatct tcaccgagtt gcgcagcctc acccctactc agtcacgatt caaggcggag      540

ctgctcagcc tgccgtacca ccacgagatc gcgctgcgtc cattcggacc ggagcaatcg      600

gcggagctgg ctcgcgccgc cttcggcccg ggcctcgccg aggatgtgct cgcggggttg      660

tataaaacga ccaggggcaa tctgagtctc agccgtggac tgatcagcga tgtgcgggag      720

gccctggcca acggagagag cgctttcgag gcgggccgcg cgttccggct ggcgtacctc      780

agctcgctct accgctgtgg cccggtcgcg ctgcgggtcg cccgagtggc tgccgtgctg      840

ggcccaagcg ccaccaccac gctggtgcgc cggctaagcg ggctcagcgc ggagacgata      900

gaccgggcaa ccaagatcct caccgagggc gggctgctgc tcgaccagca gtttccgcac      960

ccggccgccc gctcggtggt gctcgatgac atgtccgccc aggaacgacg cggcctgcac     1020

actctcgccc tggaactgct ggacgaggcg ccggttgaag tgctcgcgca ccaccaggtc     1080

ggcgccggtc tcatacacgg gcccaaggct gcggagatgt tcgccaaggc cggcaaggct     1140

ctggtcgtac gcaacgagtt gggcgacgcg gccgaatacc tgcaactggc tcaccgggcc     1200

tccgacgatg tctccacccg ggccgccctg cgggtcgagg ccgtggcgat cgagcgccgc     1260

cgcaatccgc tggcctccag tcggcacatg gacgagctga gcgccgccgg ccgcgccggt     1320

ctgctttccc ccaagcatgc ggcgctggcc gtcttctggc tggccgacgg cgggcgatcc     1380

ggcgaggcag cccaggtgct ggcgtcggaa cgcccgctcg cgaccaccga tcagaaccgg     1440

gcccacctgc gatttgtcga ggtgactctc gcgctgttct ctcccggcgc cttcggatcg     1500

gaccggcgcc cacctccgct gacgccggac gaactcgcca gcctgccgaa ggcggcctgg     1560

caatgcgcgg tcgccgacaa cgcggccatg accgccttgc acggccatcc agaacttgcc     1620

accgctcagg cggaaacagt tctgcggcag gctgattcgg cagccgacgc gatccccgcc     1680

gcgctgatcg ccctgttgta cgcggagaac accgagtccg ctcatatctg ggccgacaag     1740

ctgggcagca tgaatgccgg ggtatcgaac gaggcggaag cgggctacgc cggcccgtgc     1800

gccgagatcg ccctgcggcg cggcgacctg gccacggcgt tcgaggctgg tagcaccgtc     1860

ctggacgacc ggtcactgcc gtcgctcggc atcaccgccg cattgctgtt gagcagcaag     1920

acggccgccg ctgtccggct gggcgaactc gagcgtgcgg agaagctgct cgccgagccg     1980

cttccgaacg gcgtccagga cagccttttc ggtctgcacc tgctctcggc gtacggccag     2040

tacagcctcg cgatgggccg atatgaatcg gctcaccggg cgtttcgcac ctgcggagaa     2100

cgtatgcgca gctgggatgt tgacgtgcct ggtctggccc tgtggcgtgt cgacgccgcc     2160

gaggcgctgc tcagcctcga ccggaacgag ggccagcggc tcatcgacga acaactcacc     2220

cgtccgatgg gacctcgttc ccgcgcgctg acgctgcgga tcaaggcggc atacctcccg     2280

cggacgaagc ggatccccct gctccatgag gcggccgagc tgctgctccc ctgccccgac     2340

ccgtacgagc aagcgcgggt gctcgccgat ctgggcgaca cgctcagcgc gctcagacgc     2400

tatagccggg cgcggggagt tctccggcag gctcgtcacc tggccaccca gtgcggtgct     2460

gtcccgctgc tgcgccgact cgggggcgag cccggccgga tcgacgacgc cggcctgccg     2520

cagcggagca catcgttgac cgatgcggag cggcgggtgg cggcgctggc cgcggccgga     2580

cagaccaacc gggagatcgc cgaacagctg ttcgtcacgg ccagcacagt ggaacagcac     2640

ctcacaagcg tcttccgcaa gctgggcgtc aagggccgca agcagctgcc gaccgcgctg     2700

gccgacgtgg aacagacctg a                                               2721


<210>  191
<211>  2715
<212>  DNA
<213>  Streptomyces filamentosus

<400>  191
gtgcgagcta ttaatgcgtc cgacaccggt cctgaactgg tcgcccgcga agacgaactg       60

ggacgtgtac gaagtgccct gaaccgagcg aacggcggcc aaggtgtcct gatctccatt      120

accggtccga tcgcctgcgg caagaccgaa ctgcttgagg ctgccgcctc ggaagttgac      180

gccatcactc tgcgcgcggt ctgtgccgcc gaggaacggg cgatacctta tgccctgatc      240

gggcagctta tcgacaaccc cgcgctcggc attccggttc cggatccggc cggcctgacc      300

gcccagggcg gacgactgtc atcgagcgcc gagaaccgac tgcgtcgcga cctcacccgt      360

gccctgctga cgctcgccac cgaccggctg gtgctgatct gtgtcgatga cgtgcagcac      420

gccgacaacg cctcgttgag ctgccttctg tatctggccc gacggcttgt cccggctcga      480

atcgctctgg tattcaccga gttgcgagtc ctcacctcgt ctcagttacg gttcaacgcg      540

gagctgctca gcttgcggaa ccactgcgag atcgcgctgc gcccactcgg cccggggcat      600

gcggccgagc tggcccgcgc caccctcggc cccggcctct ccgacgaaac actcacggag      660

ctgtaccggg tgaccggagg caacctgagt ctcagccgcg ggctgatcga cgatgtgcgg      720

gacgcctggg cacgagggga aacgggcgtc caggtgggcc gggcgttccg gctggcctac      780

ctcggttccc tccaccgctg tggtccgctg gcgttgcggg tcgcccgcgt agccgccgta      840

ctgggcccga gcgccaccag cgtcctggtg cgccggatca gtgggctcag cgcggaggcc      900

atggcccagg cgaccgatat cctcgctgac ggcggcctcc tgcgcgacca gcggttcaca      960

catccagcgg cccgctcggt ggtgctcgac gacatgtccg ccgaggaacg acgcagcgtg     1020

cacagcctcg ccctggaact gctggacgag gcaccggccg agatgctcgc gcaccaccgg     1080

gtcggcgccg gtctcgtgca cgggccgaag gccgcggaga cattcaccgg ggccggccgg     1140

gcactggccg ttcgcggcat gctgggcgag gcagccgact acctgcaact ggcgtaccgg     1200

gcctccggcg acgccgctac caaggccgcg atacgcgtcg agtccgtggc ggtcgagcgc     1260

cgacgcaatc cgctggtcgt cagtcgccat tgggacgagc tgagcgtcgc ggcccgcgcc     1320

ggtctgctct cctgcgagca cgtgtccagg acggcccgct ggctgaccgt cggtgggcgg     1380

cccggcgagg cggccagggt gctggcgtcg caacaccgac gggtcgtcac cgatcaggac     1440

cgggcccacc tgcgggtcgc cgagttctcg ctcgcgctgc tgtaccccgg tacgtccggc     1500

tcggaccggc gcccgcaccc gctcacgtcg gacgaactcg cggccctacc gactgcgacc     1560

agacactgcg cgatcgccga taacgctgtc atggctgcct tgcgtggtca tccggagctt     1620

gccaccgccg aggcagaagc cgttctgcag caagccgacg cggcggacgg cgctgctctc     1680

accgcgctga tggccctgct gtacgcggag agcatcgagg tcgctgaagt ctgggcggac     1740

aagctggcgg cagaggccgg agcatcgaac gggcaggacg cggagtacgc cggtatacgc     1800

gccgaaatcg ccctgcggcg cggcgatctg accgcggccg tcgagaccgc cggcatggtc     1860

ctggacggcc ggccgctgcc gtcgctcgac atcaccgcca cgttgctgtt ggccggcagg     1920

gcgtccgtcg ccgtccggct gggcgaactc gaccacgcgg aggagctgtt cgccgcgccg     1980

ccggaggacg ccttccagga cagcctcttc ggtctgcatc tgctctcggc gcacggccag     2040

tacagcctcg cgacaggccg gcccgagtcg gcataccggg cctttcgtgc ctgcggcgaa     2100

cgtatgcgcg attggggctt cgacgcgccc ggtgtggccc tgtggcgcgt cggcgccgcc     2160

gaggcgctgc tcggcctcga ccggaacgag ggccgacggc tcatcgacga acagctgagc     2220

cggacgatgg ccccccggtc ccacgcgttg acgctgcgga taaaagcggc gtacatgccg     2280

gagccgaagc gggtcgacct gctctacgaa gcggctgagc tgctgctctc ctgccgggac     2340

cagtatgagc gagcgcgggt gctcgccgat ctgggcgagg cgctcagcgc gctcgggaac     2400

taccggcagg cgcgaggtgt gctccggcag gctcggcatc tggccatgcg aaccggcgcg     2460

gacccgctgc tgcgccggct cggaatcagg cccggccggc aggacgaccc cgacccgcag     2520

ccgcggagca gatcgctgac caacgctgag cggcgtgcgg cgtcgctggc cgcgaccgga     2580

ctgaccaacc gggagatcgc cgaccggctc ttcgtcaccg ccagcaccgt ggagcagcac     2640

ctcaccaacg tcttccgcaa gctgggcgtc aagggccgca agcagctgcc ggccgagttg     2700

gacgacatgg aatag                                                      2715


<210>  192
<211>  2715
<212>  DNA
<213>  Streptomyces filamentosus

<400>  192
atgcgagcta ttaatgcgtc cgacaccggt cctgaactgg tcgcccgcga agacgaactg       60

ggacgtgtac gaagtgccct gaaccgagcg aacggcggcc aaggtgtcct gatctccatt      120

accggtccga tcgcctgcgg caagaccgaa ctgcttgagg ctgccgcctc ggaagttgac      180

gccatcactc tgcgcgcggt ctgtgccgcc gaggaacggg cgatacctta tgccctgatc      240

gggcagctta tcgacaaccc cgcgctcggc attccggttc cggatccggc cggcctgacc      300

gcccagggcg gacgactgtc atcgagcgcc gagaaccgac tgcgtcgcga cctcacccgt      360

gccctgctga cgctcgccac cgaccggctg gtgctgatct gtgtcgatga cgtgcagcac      420

gccgacaacg cctcgttgag ctgccttctg tatctggccc gacggcttgt cccggctcga      480

atcgctctgg tattcaccga gttgcgagtc ctcacctcgt ctcagctgcg gttcaacgcg      540

gagctgctca gcttgcggaa ccactgcgag atcgcgctgc gcccactcgg cccggggcat      600

gcggccgagc tggcccgcgc caccctcggc cccggcctct ccgacgaaac actcacggag      660

ctgtaccggg tgaccggagg caacctgagt ctcagccgcg ggctgatcga cgatgtgcgg      720

gacgcctggg cacgagggga aacgggcgtc caggtgggcc gggcgttccg gctggcctac      780

ctcggttccc tccaccgctg tggtccgctg gcgttgcggg tcgcccgcgt agccgccgta      840

ctgggcccga gcgccaccag cgtcctggtg cgccggatca gtgggctcag cgcggaggcc      900

atggcccagg cgaccgatat cctcgctgac ggcggcctcc tgcgcgacca gcggttcaca      960

catccagcgg cccgctcggt ggtgctcgac gacatgtccg ccgaggaacg acgcagcgtg     1020

cacagcctcg ccctggaact gctggacgag gcaccggccg agatgctcgc gcaccaccgg     1080

gtcggcgccg gtctcgtgca cgggccgaag gccgcggaga cattcaccgg ggccggccgg     1140

gcactggccg ttcgcggcat gctgggcgag gcagccgact acctgcaact ggcgtaccgg     1200

gcctccggcg acgccgctac caaggccgcg atacgcgtcg agtccgtggc ggtcgagcgc     1260

cgacgcaatc cgctggtcgt cagtcgccat tgggacgagc tgagcgtcgc ggcccgcgcc     1320

ggtctgctct cctgcgagca cgtgtccagg acggcccgct ggctgaccgt cggtgggcgg     1380

cccggcgagg cggccagggt gctggcgtcg caacaccgac gggtcgtcac cgatcaggac     1440

cgggcccacc tgcgggtcgc cgagttctcg ctcgcgctgc tgtaccccgg tacgtccggc     1500

tcggaccggc gcccgcaccc gctcacgtcg gacgaactcg cggccctacc gactgcgacc     1560

agacactgcg cgatcgccga taacgctgtc atggctgcct tgcgtggtca tccggagctt     1620

gccaccgccg aggcagaagc cgttctgcag caagccgacg cggcggacgg cgctgctctc     1680

accgcgctga tggccctgct gtacgcggag agcatcgagg tcgctgaagt ctgggcggac     1740

aagctggcgg cagaggccgg agcatcgaac gggcaggacg cggagtacgc cggtatacgc     1800

gccgaaatcg ccctgcggcg cggcgatctg accgcggccg tcgagaccgc cggcatggtc     1860

ctggacggcc ggccgctgcc gtcgctcgac atcaccgcca cgttgctgtt ggccggcagg     1920

gcgtccgtcg ccgtccggct gggcgaactc gaccacgcgg aggagctgtt cgccgcgccg     1980

ccggaggacg ccttccagga cagcctcttc ggtctgcatc tgctctcggc gcacggccag     2040

tacagcctcg cgacaggccg gcccgagtcg gcataccggg cctttcgtgc ctgcggcgaa     2100

cgtatgcgcg attggggctt cgacgcgccc ggtgtggccc tgtggcgcgt cggcgccgcc     2160

gaggcgctgc tcggcctcga ccggaacgag ggccgacggc tcatcgacga acagctgagc     2220

cggacgatgg ccccccggtc ccacgcgttg acgctgcgga taaaagcggc gtacatgccg     2280

gagccgaagc gggtcgacct gctctacgaa gcggctgagc tgctgctctc ctgccgggac     2340

cagtatgagc gagcgcgggt gctcgccgat ctgggcgagg cgctcagcgc gctcgggaac     2400

taccggcagg cgcgaggtgt gctccggcag gctcggcatc tggccatgcg aaccggcgcg     2460

gacccgctgc tgcgccggct cggaatcagg cccggccggc aggacgaccc cgacccgcag     2520

ccgcggagca gatcgctgac caacgctgag cggcgtgcgg cgtcgctggc cgcgaccgga     2580

ctgaccaacc gggagatcgc cgaccggctc ttcgtcaccg ccagcaccgt ggagcagcac     2640

ctcaccaacg tcttccgcaa gctgggcgtc aagggccgca agcagctgcc ggccgagttg     2700

gacgacatgg aatag                                                      2715


<210>  193
<211>  894
<212>  PRT
<213>  Streptomyces hygroscopicus

<400>  193

Met Pro Ala Val Glu Cys Tyr Glu Leu Asp Ala Arg Asp Asp Glu Leu 
1               5                   10                  15      


Arg Lys Leu Glu Glu Val Val Thr Gly Arg Ala Asn Gly Arg Gly Val 
            20                  25                  30          


Val Val Thr Ile Thr Gly Pro Ile Ala Cys Gly Lys Thr Glu Leu Leu 
        35                  40                  45              


Asp Ala Ala Ala Ala Lys Ala Asp Ala Ile Thr Leu Arg Ala Val Cys 
    50                  55                  60                  


Ser Ala Glu Glu Gln Ala Leu Pro Tyr Ala Leu Ile Gly Gln Leu Ile 
65                  70                  75                  80  


Asp Asn Pro Ala Leu Ala Ser His Ala Leu Glu Pro Ala Cys Pro Thr 
                85                  90                  95      


Leu Pro Gly Glu His Leu Ser Pro Glu Ala Glu Asn Arg Leu Arg Ser 
            100                 105                 110         


Asp Leu Thr Arg Thr Leu Leu Ala Leu Ala Ala Glu Arg Pro Val Leu 
        115                 120                 125             


Ile Gly Ile Asp Glu Ser His Ala Asn Ala Leu Cys Leu Leu His Leu 
    130                 135                 140                 


Ala Arg Arg Val Gly Ser Ala Arg Ile Ala Met Val Leu Thr Glu Leu 
145                 150                 155                 160 


Arg Arg Leu Thr Pro Ala His Ser Gln Phe Gln Ala Glu Leu Leu Ser 
                165                 170                 175     


Leu Gly His His Arg Glu Ile Ala Leu Arg Pro Leu Ser Pro Lys His 
            180                 185                 190         


Thr Ala Glu Leu Val Arg Ala Gly Leu Gly Pro Asp Val Asp Glu Asp 
        195                 200                 205             


Val Leu Thr Gly Leu Tyr Arg Ala Thr Gly Gly Asn Leu Asn Leu Thr 
    210                 215                 220                 


Arg Gly Leu Ile Asn Asp Val Arg Glu Ala Trp Glu Thr Gly Gly Thr 
225                 230                 235                 240 


Gly Ile Ser Ala Gly Arg Ala Tyr Arg Leu Ala Tyr Leu Gly Ser Leu 
                245                 250                 255     


Tyr Arg Cys Gly Pro Val Pro Leu Arg Val Ala Arg Val Ala Ala Val 
            260                 265                 270         


Leu Gly Gln Ser Ala Asn Thr Thr Leu Val Arg Trp Ile Ser Gly Leu 
        275                 280                 285             


Asn Ala Asp Ala Val Gly Glu Ala Thr Glu Ile Leu Thr Glu Gly Gly 
    290                 295                 300                 


Leu Leu His Asp Leu Arg Phe Pro His Pro Ala Ala Arg Ser Val Val 
305                 310                 315                 320 


Leu Asn Asp Met Ser Ala Gln Glu Arg Arg Arg Leu His Arg Ser Ala 
                325                 330                 335     


Leu Glu Val Leu Asp Asp Val Pro Val Glu Val Val Ala His His Gln 
            340                 345                 350         


Val Gly Ala Gly Leu Leu His Gly Pro Lys Ala Ala Glu Ile Phe Ala 
        355                 360                 365             


Lys Ala Gly Gln Glu Leu His Val Arg Gly Glu Leu Asp Thr Ala Ser 
    370                 375                 380                 


Asp Tyr Leu Gln Leu Ala His Gln Ala Ser Asp Asp Ala Val Thr Gly 
385                 390                 395                 400 


Met Arg Ala Glu Ala Val Ala Ile Glu Arg Arg Arg Asn Pro Leu Ala 
                405                 410                 415     


Ser Ser Arg His Leu Asp Glu Leu Thr Val Val Ala Arg Ala Gly Leu 
            420                 425                 430         


Leu Phe Pro Glu His Thr Ala Leu Met Ile Arg Trp Leu Gly Val Gly 
        435                 440                 445             


Gly Arg Ser Gly Glu Ala Ala Gly Leu Leu Ala Ser Gln Arg Pro Arg 
    450                 455                 460                 


Ala Val Thr Asp Gln Asp Arg Ala His Met Arg Ala Ala Glu Val Ser 
465                 470                 475                 480 


Leu Ala Leu Val Ser Pro Gly Thr Ser Gly Pro Asp Arg Arg Pro Arg 
                485                 490                 495     


Pro Leu Thr Pro Asp Glu Leu Ala Asn Leu Pro Lys Ala Ala Arg Leu 
            500                 505                 510         


Cys Ala Ile Ala Asp Asn Ala Val Met Ser Ala Leu Arg Gly Arg Pro 
        515                 520                 525             


Glu Leu Ala Ala Ala Glu Ala Glu Asn Val Leu Gln His Ala Asp Ser 
    530                 535                 540                 


Ala Ala Ala Gly Thr Thr Ala Leu Ala Ala Leu Thr Ala Leu Leu Tyr 
545                 550                 555                 560 


Ala Glu Asn Thr Asp Thr Ala Gln Leu Trp Ala Asp Lys Leu Val Ser 
                565                 570                 575     


Glu Thr Gly Ala Ser Asn Glu Glu Glu Ala Gly Tyr Ala Gly Pro Arg 
            580                 585                 590         


Ala Glu Ala Ala Leu Arg Arg Gly Asp Leu Ala Ala Ala Val Glu Ala 
        595                 600                 605             


Gly Ser Thr Val Leu Asp His Arg Arg Leu Ser Thr Leu Gly Ile Thr 
    610                 615                 620                 


Ala Ala Leu Pro Leu Ser Ser Ala Val Ala Ala Ala Ile Arg Leu Gly 
625                 630                 635                 640 


Glu Thr Glu Arg Ala Glu Lys Trp Leu Ala Gln Pro Leu Pro Gln Ala 
                645                 650                 655     


Ile Gln Asp Gly Leu Phe Gly Leu His Leu Leu Ser Ala Arg Gly Gln 
            660                 665                 670         


Tyr Ser Leu Ala Thr Gly Gln His Glu Ser Ala Tyr Thr Ala Phe Arg 
        675                 680                 685             


Thr Cys Gly Glu Arg Met Arg Asn Trp Gly Val Asp Val Pro Gly Leu 
    690                 695                 700                 


Ser Leu Trp Arg Val Asp Ala Ala Glu Ala Leu Leu His Gly Arg Asp 
705                 710                 715                 720 


Arg Asp Glu Gly Arg Arg Leu Val Asp Glu Gln Leu Thr Arg Ala Met 
                725                 730                 735     


Gly Pro Arg Ser Arg Ala Leu Thr Leu Arg Val Gln Ala Ala Tyr Ser 
            740                 745                 750         


Pro Pro Ala Lys Arg Val Asp Leu Leu Asp Glu Ala Ala Asp Leu Leu 
        755                 760                 765             


Leu Ser Cys Asn Asp Gln Tyr Glu Arg Ala Arg Val Leu Ala Asp Leu 
    770                 775                 780                 


Ser Glu Thr Phe Ser Ala Leu Arg His His Ser Arg Ala Arg Gly Leu 
785                 790                 795                 800 


Leu Arg Gln Ala Arg His Leu Ala Ala Gln Arg Gly Ala Ile Pro Leu 
                805                 810                 815     


Leu Arg Arg Leu Gly Ala Lys Pro Gly Gly Pro Gly Trp Leu Glu Glu 
            820                 825                 830         


Ser Gly Leu Pro Gln Arg Ile Lys Ser Leu Thr Asp Ala Glu Arg Arg 
        835                 840                 845             


Val Ala Ser Leu Ala Ala Gly Gly Gln Thr Asn Arg Val Ile Ala Asp 
    850                 855                 860                 


Gln Leu Phe Val Thr Ala Ser Thr Val Glu Gln His Leu Thr Asp Val 
865                 870                 875                 880 


Ser Thr Gly Ser Arg Pro Pro Ala Pro Ala Ala Glu Leu Val 
                885                 890                 


<210>  194
<211>  923
<212>  PRT
<213>  Streptomyces kanamyceticus

<400>  194

Met Val Pro Glu Val Arg Ala Ala Pro Asp Glu Leu Ile Ala Arg Asp 
1               5                   10                  15      


Asp Glu Leu Ser Arg Leu Gln Arg Ala Leu Thr Arg Ala Gly Ser Gly 
            20                  25                  30          


Arg Gly Gly Val Val Ala Ile Thr Gly Pro Ile Ala Ser Gly Lys Thr 
        35                  40                  45              


Ala Leu Leu Asp Ala Gly Ala Ala Lys Ser Gly Phe Val Ala Leu Arg 
    50                  55                  60                  


Ala Val Cys Ser Trp Glu Glu Arg Thr Leu Pro Tyr Gly Met Leu Gly 
65                  70                  75                  80  


Gln Leu Phe Asp His Pro Glu Leu Ala Ala Gln Ala Pro Asp Leu Ala 
                85                  90                  95      


His Phe Thr Ala Ser Cys Glu Ser Pro Gln Ala Gly Thr Asp Asn Arg 
            100                 105                 110         


Leu Arg Ala Glu Phe Thr Arg Thr Leu Leu Ala Leu Ala Ala Asp Trp 
        115                 120                 125             


Pro Val Leu Ile Gly Ile Asp Asp Val His His Ala Asp Ala Glu Ser 
    130                 135                 140                 


Leu Arg Cys Leu Leu His Leu Ala Arg Arg Ile Gly Pro Ala Arg Ile 
145                 150                 155                 160 


Ala Val Val Leu Thr Glu Leu Arg Arg Pro Thr Pro Ala Asp Ser Arg 
                165                 170                 175     


Phe Gln Ala Glu Leu Leu Ser Leu Arg Ser Tyr Gln Glu Ile Ala Leu 
            180                 185                 190         


Arg Pro Leu Thr Glu Ala Gln Thr Gly Glu Leu Val Arg Arg His Leu 
        195                 200                 205             


Gly Ala Glu Thr His Glu Asp Val Ser Ala Asp Thr Phe Arg Ala Thr 
    210                 215                 220                 


Gly Gly Asn Leu Leu Leu Gly His Gly Leu Ile Asn Asp Ile Arg Glu 
225                 230                 235                 240 


Ala Arg Thr Ala Gly Arg Pro Gly Val Val Ala Gly Arg Ala Tyr Arg 
                245                 250                 255     


Leu Ala Tyr Leu Ser Ser Leu Tyr Arg Cys Gly Pro Ser Ala Leu Arg 
            260                 265                 270         


Val Ala Arg Ala Ser Ala Val Leu Gly Ala Ser Ala Glu Ala Val Leu 
        275                 280                 285             


Val Gln Arg Met Thr Gly Leu Asn Lys Asp Ala Val Glu Gln Val Tyr 
    290                 295                 300                 


Glu Gln Leu Asn Glu Gly Arg Leu Leu Gln Gly Glu Arg Phe Pro His 
305                 310                 315                 320 


Pro Ala Ala Arg Ser Ile Val Leu Asp Asp Leu Ser Ala Leu Glu Arg 
                325                 330                 335     


Arg Asn Leu His Glu Ser Ala Leu Glu Leu Leu Arg Asp His Gly Val 
            340                 345                 350         


Ala Gly Asn Val Leu Ala Arg His Gln Ile Gly Ala Gly Arg Val His 
        355                 360                 365             


Gly Glu Glu Ala Val Glu Leu Phe Thr Gly Ala Ala Arg Glu His His 
    370                 375                 380                 


Leu Arg Gly Glu Leu Asp Asp Ala Ala Gly Tyr Leu Glu Leu Ala His 
385                 390                 395                 400 


Arg Ala Ser Asp Asp Pro Val Thr Arg Ala Ala Leu Arg Val Gly Ala 
                405                 410                 415     


Ala Ala Ile Glu Arg Leu Cys Asn Pro Val Arg Ala Gly Arg His Leu 
            420                 425                 430         


Pro Glu Leu Leu Thr Ala Ser Arg Ala Gly Leu Leu Ser Ser Glu His 
        435                 440                 445             


Ala Val Ser Leu Ala Asp Trp Leu Ala Met Gly Gly Arg Pro Gly Glu 
    450                 455                 460                 


Ala Ala Glu Val Leu Ala Thr Gln Arg Pro Ala Ala Asp Ser Glu Gln 
465                 470                 475                 480 


His Arg Ala Leu Leu Arg Ser Gly Glu Leu Ser Leu Ala Leu Val His 
                485                 490                 495     


Pro Gly Ala Trp Asp Pro Leu Arg Arg Thr Asp Arg Phe Ala Ala Gly 
            500                 505                 510         


Gly Leu Gly Ser Leu Pro Gly Pro Ala Arg His Arg Ala Val Ala Asp 
        515                 520                 525             


Gln Ala Val Ile Ala Ala Leu Arg Gly Arg Leu Asp Arg Ala Asp Ala 
    530                 535                 540                 


Asn Ala Glu Ser Val Leu Gln His Thr Asp Ala Thr Ala Asp Arg Thr 
545                 550                 555                 560 


Thr Ala Ile Met Ala Leu Leu Ala Leu Leu Tyr Ala Glu Asn Thr Asp 
                565                 570                 575     


Ala Val Gln Phe Trp Val Asp Lys Leu Ala Gly Asp Glu Gly Thr Arg 
            580                 585                 590         


Thr Pro Ala Asp Glu Ala Val His Ala Gly Phe Asn Ala Glu Ile Ala 
        595                 600                 605             


Leu Arg Arg Gly Asp Leu Met Arg Ala Val Glu Tyr Gly Glu Ala Ala 
    610                 615                 620                 


Leu Gly His Arg His Leu Pro Thr Trp Gly Met Ala Ala Ala Leu Pro 
625                 630                 635                 640 


Leu Ser Ser Thr Val Val Ala Ala Ile Arg Leu Gly Asp Leu Asp Arg 
                645                 650                 655     


Ala Glu Arg Trp Leu Ala Glu Pro Leu Pro Gln Gln Thr Pro Glu Ser 
            660                 665                 670         


Leu Phe Gly Leu His Leu Leu Trp Ala Arg Gly Gln His His Leu Ala 
        675                 680                 685             


Thr Gly Arg His Gly Ala Ala Tyr Thr Ala Phe Arg Glu Cys Gly Glu 
    690                 695                 700                 


Arg Met Arg Arg Trp Ala Val Asp Val Pro Gly Leu Ala Leu Trp Arg 
705                 710                 715                 720 


Val Asp Ala Ala Glu Ser Leu Leu Leu Leu Gly Arg Asp Arg Ala Glu 
                725                 730                 735     


Gly Leu Arg Leu Val Ser Glu Gln Leu Ser Arg Pro Met Arg Pro Arg 
            740                 745                 750         


Ala Arg Val Gln Thr Leu Arg Val Gln Ala Ala Tyr Ser Pro Pro Pro 
        755                 760                 765             


Gln Arg Ile Asp Leu Leu Glu Glu Ala Ala Asp Leu Leu Val Thr Cys 
    770                 775                 780                 


Asn Asp Gln Tyr Glu Leu Ala Asn Val Leu Ser Asp Leu Ala Glu Ala 
785                 790                 795                 800 


Ser Ser Met Val Arg Gln His Ser Arg Ala Arg Gly Leu Leu Arg Arg 
                805                 810                 815     


Ala Arg His Leu Ala Thr Gln Cys Gly Ala Val Pro Leu Leu Arg Arg 
            820                 825                 830         


Leu Gly Ala Glu Pro Ser Asp Ile Gly Gly Ala Trp Asp Ala Thr Leu 
        835                 840                 845             


Gly Gln Arg Ile Ala Ser Leu Thr Glu Ser Glu Arg Arg Val Ala Ala 
    850                 855                 860                 


Leu Ala Ala Val Gly Arg Thr Asn Arg Glu Ile Ala Glu Gln Leu Phe 
865                 870                 875                 880 


Val Thr Ala Ser Thr Val Glu Gln His Leu Thr Asn Val Phe Arg Lys 
                885                 890                 895     


Leu Ala Val Lys Gly Arg Gln Gln Leu Pro Lys Glu Leu Ala Asp Val 
            900                 905                 910         


Gly Glu Pro Ala Asp Arg Asp Arg Arg Cys Gly 
        915                 920             


<210>  195
<211>  913
<212>  PRT
<213>  Streptomyces ascomyceticus

<400>  195

Met Ile Ala Arg Leu Ser Pro Pro Asp Leu Ile Ala Arg Asp Asp Glu 
1               5                   10                  15      


Phe Gly Ser Leu His Arg Ala Leu Thr Arg Ala Gly Gly Gly Arg Gly 
            20                  25                  30          


Val Val Ala Ala Val Thr Gly Pro Ile Ala Cys Gly Lys Thr Glu Leu 
        35                  40                  45              


Leu Asp Ala Ala Ala Ala Lys Ala Gly Phe Val Thr Leu Arg Ala Val 
    50                  55                  60                  


Cys Ser Met Glu Glu Arg Ala Leu Pro Tyr Gly Met Leu Gly Gln Leu 
65                  70                  75                  80  


Leu Asp Gln Pro Glu Leu Ala Ala Arg Thr Pro Glu Leu Val Arg Leu 
                85                  90                  95      


Thr Ala Ser Cys Glu Asn Leu Pro Ala Asp Val Asp Asn Arg Leu Gly 
            100                 105                 110         


Thr Glu Leu Thr Arg Thr Val Leu Thr Leu Ala Ala Glu Arg Pro Val 
        115                 120                 125             


Leu Ile Gly Ile Asp Asp Val His His Ala Asp Ala Pro Ser Leu Arg 
    130                 135                 140                 


Cys Leu Leu His Leu Ala Arg Arg Ile Ser Arg Ala Arg Val Ala Ile 
145                 150                 155                 160 


Val Leu Thr Glu Leu Leu Arg Pro Thr Pro Ala His Ser Gln Phe Arg 
                165                 170                 175     


Ala Ala Leu Leu Ser Leu Arg His Tyr Gln Glu Ile Ala Leu Arg Pro 
            180                 185                 190         


Leu Thr Glu Ala Gln Thr Thr Glu Leu Val Arg Arg His Leu Gly Gln 
        195                 200                 205             


Asp Ala His Asp Asp Val Val Ala Gln Ala Phe Arg Ala Thr Gly Gly 
    210                 215                 220                 


Asn Leu Leu Leu Gly His Gly Leu Ile Asp Asp Ile Arg Glu Ala Arg 
225                 230                 235                 240 


Thr Arg Thr Ser Gly Cys Leu Glu Val Val Ala Gly Arg Ala Tyr Arg 
                245                 250                 255     


Leu Ala Tyr Leu Gly Ser Leu Tyr Arg Cys Gly Pro Ala Ala Leu Ser 
            260                 265                 270         


Val Ala Arg Ala Ser Ala Val Leu Gly Glu Ser Val Glu Leu Thr Leu 
        275                 280                 285             


Val Gln Arg Met Thr Gly Leu Asp Thr Glu Ala Val Glu Gln Ala His 
    290                 295                 300                 


Glu Gln Leu Val Glu Gly Arg Leu Leu Arg Glu Gly Arg Phe Pro His 
305                 310                 315                 320 


Pro Ala Ala Arg Ser Val Val Leu Asp Asp Leu Ser Ala Ala Glu Arg 
                325                 330                 335     


Arg Gly Leu His Glu Leu Ala Leu Glu Leu Leu Arg Asp Arg Gly Val 
            340                 345                 350         


Ala Ser Lys Val Leu Ala Arg His Gln Met Gly Thr Gly Arg Val His 
        355                 360                 365             


Gly Ala Glu Val Ala Gly Leu Phe Thr Asp Ala Ala Arg Glu His His 
    370                 375                 380                 


Leu Arg Gly Glu Leu Asp Glu Ala Val Thr Tyr Leu Glu Phe Ala Tyr 
385                 390                 395                 400 


Arg Ala Ser Asp Asp Pro Ala Val His Ala Ala Leu Arg Val Asp Thr 
                405                 410                 415     


Ala Ala Ile Glu Arg Leu Cys Asp Pro Ala Arg Ser Gly Arg His Val 
            420                 425                 430         


Pro Glu Leu Leu Thr Ala Ser Arg Glu Arg Leu Leu Ser Ser Glu His 
        435                 440                 445             


Ala Val Ser Leu Ala Cys Trp Leu Ala Met Asp Gly Arg Pro Gly Glu 
    450                 455                 460                 


Ala Ala Glu Val Leu Ala Ala Gln Arg Ser Ala Ala Pro Ser Glu Gln 
465                 470                 475                 480 


Gly Arg Ala His Leu Arg Val Ala Asp Leu Ser Leu Ala Leu Ile Tyr 
                485                 490                 495     


Pro Gly Ala Ala Asp Pro Pro Arg Pro Ala Asp Pro Pro Ala Glu Asp 
            500                 505                 510         


Glu Val Ala Ser Phe Ser Gly Ala Val Arg His Arg Ala Val Ala Asp 
        515                 520                 525             


Lys Ala Leu Ser Asn Ala Leu Arg Gly Trp Ser Glu Gln Ala Glu Ala 
    530                 535                 540                 


Lys Ala Glu Tyr Val Leu Gln His Ser Arg Val Thr Thr Asp Arg Thr 
545                 550                 555                 560 


Thr Thr Met Met Ala Leu Leu Ala Leu Leu Tyr Ala Glu Asp Thr Asp 
                565                 570                 575     


Ala Val Gln Ser Trp Val Asp Lys Leu Ala Gly Asp Asp Asn Met Arg 
            580                 585                 590         


Thr Pro Ala Asp Glu Ala Val His Ala Gly Phe Arg Ala Glu Ala Ala 
        595                 600                 605             


Leu Arg Arg Gly Asp Leu Thr Ala Ala Val Glu Cys Gly Glu Ala Ala 
    610                 615                 620                 


Leu Ala Pro Arg Val Val Pro Ser Trp Gly Met Ala Ala Ala Leu Pro 
625                 630                 635                 640 


Leu Ser Ser Thr Val Ala Ala Ala Ile Arg Leu Gly Asp Leu Asp Arg 
                645                 650                 655     


Ala Glu Arg Trp Leu Ala Glu Pro Leu Pro Glu Glu Thr Ser Asp Ser 
            660                 665                 670         


Leu Phe Gly Leu His Met Val Trp Ala Arg Gly Gln His His Leu Ala 
        675                 680                 685             


Ala Gly Arg Tyr Arg Ala Ala Tyr Asn Ala Phe Arg Asp Cys Gly Glu 
    690                 695                 700                 


Arg Met Arg Arg Trp Ser Val Asp Val Pro Gly Leu Ala Leu Trp Arg 
705                 710                 715                 720 


Val Asp Ala Ala Glu Ala Leu Leu Leu Leu Gly Arg Gly Arg Asp Glu 
                725                 730                 735     


Gly Leu Arg Leu Ile Ser Glu Gln Leu Ser Arg Pro Met Gly Ser Arg 
            740                 745                 750         


Ala Arg Val Met Thr Leu Arg Val Gln Ala Ala Tyr Ser Pro Pro Ala 
        755                 760                 765             


Lys Arg Ile Glu Leu Leu Asp Glu Ala Ala Asp Leu Leu Ile Met Cys 
    770                 775                 780                 


Arg Asp Gln Tyr Glu Leu Ala Arg Val Leu Ala Asp Met Gly Glu Ala 
785                 790                 795                 800 


Cys Gly Met Leu Arg Arg His Ser Arg Ala Arg Gly Leu Phe Arg Arg 
                805                 810                 815     


Ala Arg His Leu Ala Thr Gln Cys Gly Ala Val Pro Leu Leu Arg Arg 
            820                 825                 830         


Leu Gly Gly Glu Ser Ser Asp Ala Asp Gly Thr Gln Asp Val Thr Pro 
        835                 840                 845             


Ala Gln Arg Ile Thr Ser Leu Thr Glu Ala Glu Arg Arg Val Ala Ser 
    850                 855                 860                 


His Ala Ala Val Gly Arg Thr Asn Lys Glu Ile Ala Ser Gln Leu Phe 
865                 870                 875                 880 


Val Thr Ser Ser Thr Val Glu Gln His Leu Thr Asn Val Phe Arg Lys 
                885                 890                 895     


Leu Gly Val Lys Gly Arg Gln Gln Leu Pro Lys Glu Leu Ser Asp Ala 
            900                 905                 910         


Gly 
    


<210>  196
<211>  901
<212>  PRT
<213>  Micromonospora sp. S92-306401

<400>  196

Met Glu Phe Tyr Asp Leu Val Ala Arg Asp Asp Glu Leu Arg Arg Leu 
1               5                   10                  15      


Asp Gln Ala Leu Gly Arg Ala Ala Gly Gly Arg Gly Val Val Val Thr 
            20                  25                  30          


Val Thr Gly Pro Val Gly Cys Gly Lys Thr Glu Leu Leu Asp Ala Ala 
        35                  40                  45              


Ala Ala Glu Glu Glu Phe Ile Thr Leu Arg Ala Val Cys Ser Ala Glu 
    50                  55                  60                  


Glu Arg Ala Leu Pro Tyr Ala Val Ile Gly Gln Leu Leu Asp His Pro 
65                  70                  75                  80  


Val Leu Ser Ala Arg Ala Pro Asp Leu Ala Cys Val Thr Ala Pro Gly 
                85                  90                  95      


Arg Thr Leu Pro Ala Asp Thr Glu Asn Arg Leu Arg Arg Asp Leu Thr 
            100                 105                 110         


Arg Ala Leu Leu Ala Leu Ala Ser Glu Arg Pro Val Leu Ile Cys Ile 
        115                 120                 125             


Asp Asp Val His Gln Ala Asp Thr Ala Ser Leu Asn Cys Leu Leu His 
    130                 135                 140                 


Leu Ala Arg Arg Val Ala Ser Ala Arg Ile Ala Met Ile Leu Thr Glu 
145                 150                 155                 160 


Leu Arg Arg Leu Thr Pro Ala His Ser Arg Phe Glu Ala Glu Leu Leu 
                165                 170                 175     


Ser Leu Arg His Arg His Glu Ile Ala Leu Arg Pro Leu Gly Pro Ala 
            180                 185                 190         


Asp Thr Ala Glu Leu Ala Arg Ala Arg Leu Gly Ala Gly Val Thr Ala 
        195                 200                 205             


Asp Glu Leu Ala Gln Val His Glu Ala Thr Ser Gly Asn Pro Asn Leu 
    210                 215                 220                 


Val Gly Gly Leu Val Asn Asp Val Arg Glu Ala Trp Ala Ala Gly Gly 
225                 230                 235                 240 


Thr Gly Ile Ala Ala Gly Arg Ala Tyr Arg Leu Ala Tyr Leu Ser Ser 
                245                 250                 255     


Val Tyr Arg Cys Gly Pro Val Pro Leu Arg Ile Ala Gln Ala Ala Ala 
            260                 265                 270         


Val Leu Gly Pro Ser Ala Thr Val Thr Leu Val Arg Arg Ile Ser Gly 
        275                 280                 285             


Leu Asp Ala Glu Thr Val Asp Glu Ala Thr Ala Ile Leu Thr Glu Gly 
    290                 295                 300                 


Gly Leu Leu Arg Asp His Arg Phe Pro His Pro Ala Ala Arg Ser Val 
305                 310                 315                 320 


Val Leu Asp Asp Met Ser Ala Gln Glu Arg Arg Arg Leu His Arg Ser 
                325                 330                 335     


Thr Leu Asp Val Leu Asp Gly Val Pro Val Asp Val Leu Ala His His 
            340                 345                 350         


Gln Ala Gly Ala Gly Leu Leu His Gly Pro Gln Ala Ala Glu Met Phe 
        355                 360                 365             


Ala Arg Ala Ser Gln Glu Leu Arg Val Arg Gly Glu Leu Asp Ala Ala 
    370                 375                 380                 


Thr Glu Tyr Leu Gln Leu Ala Tyr Arg Ala Ser Asp Asp Ala Gly Ala 
385                 390                 395                 400 


Arg Ala Ala Leu Gln Val Glu Thr Val Ala Gly Glu Arg Arg Arg Asn 
                405                 410                 415     


Pro Leu Ala Ala Ser Arg His Leu Asp Glu Leu Ala Ala Ala Ala Arg 
            420                 425                 430         


Ala Gly Leu Leu Ser Ala Glu His Ala Ala Leu Val Val His Trp Leu 
        435                 440                 445             


Ala Asp Ala Gly Arg Pro Gly Glu Ala Ala Glu Val Leu Ala Leu Gln 
    450                 455                 460                 


Arg Ala Leu Ala Val Thr Asp His Asp Arg Ala Arg Leu Arg Ala Ala 
465                 470                 475                 480 


Glu Val Ser Leu Ala Leu Phe His Pro Gly Val Pro Gly Ser Asp Pro 
                485                 490                 495     


Arg Pro Leu Ala Pro Glu Glu Leu Ala Ser Leu Ser Leu Ser Ala Arg 
            500                 505                 510         


His Gly Val Thr Ala Asp Asn Ala Val Leu Ala Ala Leu Arg Gly Arg 
        515                 520                 525             


Pro Glu Ser Ala Ala Ala Glu Ala Glu Asn Val Leu Arg Asn Ala Asp 
    530                 535                 540                 


Ala Ala Ala Ser Gly Pro Thr Ala Leu Ala Ala Leu Thr Ala Leu Leu 
545                 550                 555                 560 


Tyr Ala Glu Asn Thr Asp Ala Ala Gln Leu Trp Ala Asp Lys Leu Ala 
                565                 570                 575     


Ala Gly Ile Gly Ala Gly Glu Gly Glu Ala Gly Tyr Ala Gly Pro Arg 
            580                 585                 590         


Thr Val Ala Ala Leu Arg Arg Gly Asp Leu Thr Thr Ala Val Gln Ala 
        595                 600                 605             


Ala Gly Ala Val Leu Asp Arg Gly Arg Pro Ser Ser Leu Gly Ile Thr 
    610                 615                 620                 


Ala Val Leu Pro Leu Ser Gly Ala Val Ala Ala Ala Ile Arg Leu Gly 
625                 630                 635                 640 


Glu Leu Glu Arg Ala Glu Lys Trp Leu Ala Glu Pro Leu Pro Glu Ala 
                645                 650                 655     


Val His Asp Ser Leu Phe Gly Leu His Leu Leu Met Ala Arg Gly Arg 
            660                 665                 670         


Tyr Ser Leu Ala Val Gly Arg His Glu Ala Ala Tyr Ala Ala Phe Arg 
        675                 680                 685             


Asp Cys Gly Glu Arg Met Arg Arg Trp Asp Val Asp Val Pro Gly Leu 
    690                 695                 700                 


Ala Leu Trp Arg Val Asp Ala Ala Glu Ala Leu Leu Pro Gly Asp Asp 
705                 710                 715                 720 


Arg Ala Glu Gly Arg Arg Leu Ile Asp Glu Gln Leu Thr Arg Pro Met 
                725                 730                 735     


Gly Pro Arg Ser Arg Ala Leu Thr Leu Arg Val Arg Ala Ala Tyr Ala 
            740                 745                 750         


Pro Pro Ala Lys Arg Ile Asp Leu Leu Asp Glu Ala Ala Asp Leu Leu 
        755                 760                 765             


Leu Ser Ser Asn Asp Gln Tyr Glu Arg Ala Arg Val Leu Ala Asp Leu 
    770                 775                 780                 


Ser Glu Ala Phe Ser Ala Leu Arg Gln Asn Gly Arg Ala Arg Gly Ile 
785                 790                 795                 800 


Leu Arg Gln Ala Arg His Leu Ala Ala Gln Cys Gly Ala Val Pro Leu 
                805                 810                 815     


Leu Arg Arg Leu Gly Val Lys Ala Gly Arg Ser Gly Arg Leu Gly Arg 
            820                 825                 830         


Pro Pro Gln Gly Ile Arg Ser Leu Thr Glu Ala Glu Arg Arg Val Ala 
        835                 840                 845             


Thr Leu Ala Ala Ala Gly Gln Thr Asn Arg Glu Ile Ala Asp Gln Leu 
    850                 855                 860                 


Phe Val Thr Ala Ser Thr Val Glu Gln His Leu Thr Asn Val Phe Arg 
865                 870                 875                 880 


Lys Leu Gly Val Lys Gly Arg Gln Gln Leu Pro Ala Glu Leu Ala Asp 
                885                 890                 895     


Leu Arg Pro Pro Gly 
            900     


<210>  197
<211>  906
<212>  PRT
<213>  Streptomyces violaceusniger

<400>  197

Met Tyr Ser Gly Thr Cys Arg Glu Gly Tyr Glu Leu Val Ala Arg Glu 
1               5                   10                  15      


Asp Glu Leu Gly Ile Leu Gln Arg Ser Leu Glu Gln Ala Ser Ser Gly 
            20                  25                  30          


Gln Gly Val Val Val Thr Val Thr Gly Pro Ile Ala Cys Gly Lys Thr 
        35                  40                  45              


Glu Leu Leu Asp Ala Ala Ala Ala Lys Ala Glu Ala Ile Ile Leu Arg 
    50                  55                  60                  


Ala Val Cys Ala Pro Glu Glu Arg Ala Met Pro Tyr Ala Met Ile Gly 
65                  70                  75                  80  


Gln Leu Ile Asp Asp Pro Ala Leu Ala His Arg Ala Pro Gly Leu Ala 
                85                  90                  95      


Asp Arg Ile Ala Gln Gly Gly Gln Leu Ser Leu Arg Ala Glu Asn Arg 
            100                 105                 110         


Leu Arg Arg Asp Leu Thr Arg Ala Leu Leu Ala Leu Ala Val Asp Arg 
        115                 120                 125             


Pro Val Leu Ile Gly Val Asp Asp Val His His Ala Asp Thr Ala Ser 
    130                 135                 140                 


Leu Asn Cys Leu Leu His Leu Ala Arg Arg Val Arg Pro Ala Arg Ile 
145                 150                 155                 160 


Ser Met Ile Phe Thr Glu Leu Arg Ser Leu Thr Pro Thr Gln Ser Arg 
                165                 170                 175     


Phe Lys Ala Glu Leu Leu Ser Leu Pro Tyr His His Glu Ile Ala Leu 
            180                 185                 190         


Arg Pro Phe Gly Pro Glu Gln Ser Ala Glu Leu Ala Arg Ala Ala Phe 
        195                 200                 205             


Gly Pro Gly Leu Ala Glu Asp Val Leu Val Gly Leu Tyr Lys Thr Thr 
    210                 215                 220                 


Arg Gly Asn Leu Ser Leu Ser Arg Gly Leu Ile Ser Asp Val Arg Glu 
225                 230                 235                 240 


Ala Leu Ala Asn Gly Glu Ser Ala Phe Glu Ala Gly Arg Ala Phe Arg 
                245                 250                 255     


Leu Ala Tyr Leu Gly Ser Leu Tyr Arg Cys Gly Pro Val Ala Leu Arg 
            260                 265                 270         


Val Ala Arg Val Ala Ala Val Leu Gly Pro Ser Ala Thr Thr Thr Leu 
        275                 280                 285             


Val Arg Arg Leu Ser Gly Leu Ser Ala Glu Thr Ile Asp Arg Ala Thr 
    290                 295                 300                 


Lys Ile Leu Thr Glu Gly Gly Leu Leu Leu Asp Gln Gln Phe Pro His 
305                 310                 315                 320 


Pro Ala Ala Arg Ser Val Val Leu Asp Asp Met Ser Ala Gln Glu Arg 
                325                 330                 335     


Arg Gly Leu His Thr Leu Ala Leu Glu Leu Leu Asp Glu Ala Pro Val 
            340                 345                 350         


Glu Val Leu Ala His His Gln Val Gly Ala Gly Leu Ile His Gly Pro 
        355                 360                 365             


Lys Ala Ala Glu Met Phe Ala Lys Ala Gly Lys Ala Leu Val Val Arg 
    370                 375                 380                 


Asn Glu Leu Gly Asp Ala Ala Glu Tyr Leu Gln Leu Ala His Arg Ala 
385                 390                 395                 400 


Ser Asp Asp Val Ser Thr Arg Ala Ala Leu Arg Val Glu Ala Val Ala 
                405                 410                 415     


Ile Glu Arg Arg Arg Asn Pro Leu Ala Ser Ser Arg His Met Asp Glu 
            420                 425                 430         


Leu Ser Ala Ala Gly Arg Ala Gly Leu Leu Ser Pro Lys His Ala Ala 
        435                 440                 445             


Leu Ala Val Phe Trp Leu Ala Asp Gly Gly Arg Ser Gly Glu Ala Ala 
    450                 455                 460                 


Glu Val Leu Ala Ser Glu Arg Pro Leu Ala Thr Thr Asp Gln Asn Arg 
465                 470                 475                 480 


Ala His Leu Arg Phe Val Glu Val Thr Leu Ala Leu Phe Ser Pro Gly 
                485                 490                 495     


Ala Phe Gly Ser Asp Arg Arg Pro Pro Pro Leu Thr Pro Asp Glu Leu 
            500                 505                 510         


Ala Ser Leu Pro Lys Ala Ala Trp Gln Cys Ala Val Ala Asp Asn Ala 
        515                 520                 525             


Ala Met Thr Ala Leu His Gly His Pro Glu Leu Ala Thr Ala Gln Ala 
    530                 535                 540                 


Glu Thr Val Leu Arg Gln Ala Asp Ser Ala Ala Asp Ala Ile Pro Ala 
545                 550                 555                 560 


Ala Leu Ile Ala Leu Leu Tyr Ala Glu Asn Thr Glu Ser Ala His Ile 
                565                 570                 575     


Trp Ala Asp Lys Leu Gly Ser Thr Asn Gly Gly Val Ser Asn Glu Ala 
            580                 585                 590         


Glu Ala Gly Tyr Ala Gly Pro Cys Ala Glu Ile Ala Leu Arg Arg Gly 
        595                 600                 605             


Asp Leu Ala Thr Ala Phe Glu Ala Gly Ser Thr Val Leu Asp Asp Arg 
    610                 615                 620                 


Ser Leu Pro Ser Leu Gly Ile Thr Ala Ala Leu Leu Leu Ser Ser Lys 
625                 630                 635                 640 


Thr Ala Ala Ala Val Arg Leu Gly Glu Leu Glu Arg Ala Glu Lys Leu 
                645                 650                 655     


Leu Ala Glu Pro Leu Pro Asn Gly Val Gln Asp Ser Leu Phe Gly Leu 
            660                 665                 670         


His Leu Leu Ser Ala Tyr Gly Gln Tyr Ser Leu Ala Met Gly Arg Tyr 
        675                 680                 685             


Glu Ser Ala Leu Arg Ala Phe His Thr Cys Gly Glu Arg Met Arg Ser 
    690                 695                 700                 


Trp Asp Val Asp Val Pro Gly Leu Ala Leu Trp Arg Val Asp Ala Ala 
705                 710                 715                 720 


Glu Ala Leu Leu Ser Leu Asp Arg Asn Glu Gly Gln Arg Leu Ile Asp 
                725                 730                 735     


Glu Gln Leu Thr Arg Pro Met Gly Pro Arg Ser Arg Ala Leu Thr Leu 
            740                 745                 750         


Arg Ile Lys Ala Ala Tyr Leu Pro Arg Thr Lys Arg Ile Pro Leu Leu 
        755                 760                 765             


His Glu Ala Ala Glu Leu Leu Leu Pro Cys Pro Asp Pro Tyr Glu Gln 
    770                 775                 780                 


Ala Arg Val Leu Ala Asp Leu Gly Asp Thr Leu Ser Ala Leu Arg Arg 
785                 790                 795                 800 


Tyr Ser Arg Ala Arg Gly Val Leu Arg Gln Ala Arg His Leu Ala Ala 
                805                 810                 815     


Gln Cys Gly Ala Val Pro Leu Leu Arg Arg Leu Gly Gly Glu Pro Gly 
            820                 825                 830         


Arg Ile Asp Asp Ala Gly Leu Pro Gln Arg Ser Thr Ser Leu Thr Asp 
        835                 840                 845             


Ala Glu Arg Arg Val Ala Ala Leu Ala Ala Ala Gly Gln Thr Asn Arg 
    850                 855                 860                 


Glu Ile Ala Lys Gln Leu Phe Val Thr Ala Ser Thr Val Glu Gln His 
865                 870                 875                 880 


Leu Thr Ser Val Phe Arg Lys Leu Gly Val Lys Gly Arg Lys Gln Leu 
                885                 890                 895     


Pro Thr Ala Leu Ala Asp Val Glu Gln Thr 
            900                 905     


<210>  198
<211>  914
<212>  PRT
<213>  Streptomyces hygroscopicus

<400>  198

Met Pro Ala Val Glu Ser Tyr Glu Leu Asp Ala Arg Asp Asp Glu Leu 
1               5                   10                  15      


Arg Arg Leu Glu Glu Ala Val Gly Gln Ala Gly Asn Gly Arg Gly Val 
            20                  25                  30          


Val Val Thr Ile Thr Gly Pro Ile Ala Cys Gly Lys Thr Glu Leu Leu 
        35                  40                  45              


Asp Ala Ala Ala Ala Lys Ser Asp Ala Ile Thr Leu Arg Ala Val Cys 
    50                  55                  60                  


Ser Glu Glu Glu Arg Ala Leu Pro Tyr Ala Leu Ile Gly Gln Leu Ile 
65                  70                  75                  80  


Asp Asn Pro Ala Val Ala Ser Gln Leu Pro Asp Pro Val Ser Met Ala 
                85                  90                  95      


Leu Pro Gly Glu His Leu Ser Pro Glu Ala Glu Asn Arg Leu Arg Gly 
            100                 105                 110         


Asp Leu Thr Arg Thr Leu Leu Ala Leu Ala Ala Glu Arg Pro Val Leu 
        115                 120                 125             


Ile Gly Ile Asp Asp Met His His Ala Asp Thr Ala Ser Leu Asn Cys 
    130                 135                 140                 


Leu Leu His Leu Ala Arg Arg Val Gly Pro Ala Arg Ile Ala Met Val 
145                 150                 155                 160 


Leu Thr Glu Leu Arg Arg Leu Thr Pro Ala His Ser Gln Phe His Ala 
                165                 170                 175     


Glu Leu Leu Ser Leu Gly His His Arg Glu Ile Ala Leu Arg Pro Leu 
            180                 185                 190         


Gly Pro Lys His Ile Ala Glu Leu Ala Arg Ala Gly Leu Gly Pro Asp 
        195                 200                 205             


Val Asp Glu Asp Val Leu Thr Gly Leu Tyr Arg Ala Thr Gly Gly Asn 
    210                 215                 220                 


Leu Asn Leu Gly His Gly Leu Ile Lys Asp Val Arg Glu Ala Trp Ala 
225                 230                 235                 240 


Thr Gly Gly Thr Gly Ile Asn Ala Gly Arg Ala Tyr Arg Leu Ala Tyr 
                245                 250                 255     


Leu Gly Ser Leu Tyr Arg Cys Gly Pro Val Pro Leu Arg Val Ala Arg 
            260                 265                 270         


Val Ala Ala Val Leu Gly Gln Ser Ala Asn Thr Thr Leu Val Arg Trp 
        275                 280                 285             


Ile Ser Gly Leu Asn Ala Asp Ala Val Gly Glu Ala Thr Glu Ile Leu 
    290                 295                 300                 


Thr Glu Gly Gly Leu Leu His Asp Leu Arg Phe Pro His Pro Ala Ala 
305                 310                 315                 320 


Arg Ser Val Val Leu Asn Asp Leu Ser Ala Arg Glu Arg Arg Arg Leu 
                325                 330                 335     


His Arg Ser Ala Leu Glu Val Leu Asp Asp Val Pro Val Glu Val Val 
            340                 345                 350         


Ala His His Gln Ala Gly Ala Gly Phe Ile His Gly Pro Lys Ala Ala 
        355                 360                 365             


Glu Ile Phe Ala Lys Ala Gly Gln Glu Leu His Val Arg Gly Glu Leu 
    370                 375                 380                 


Asp Ala Ala Ser Asp Tyr Leu Gln Leu Ala His His Ala Ser Asp Asp 
385                 390                 395                 400 


Ala Val Thr Arg Ala Ala Leu Arg Val Glu Ala Val Ala Ile Glu Arg 
                405                 410                 415     


Arg Arg Asn Pro Leu Ala Ser Ser Arg His Leu Asp Glu Leu Thr Val 
            420                 425                 430         


Ala Ala Arg Ala Gly Leu Leu Ser Leu Glu His Ala Ala Leu Met Ile 
        435                 440                 445             


Arg Trp Leu Ala Leu Gly Gly Arg Ser Gly Glu Ala Ala Glu Val Leu 
    450                 455                 460                 


Ala Ala Gln Arg Pro Arg Ala Val Thr Asp Gln Asp Arg Ala His Leu 
465                 470                 475                 480 


Arg Ala Ala Glu Val Ser Leu Ala Leu Val Ser Pro Gly Ala Ser Gly 
                485                 490                 495     


Val Ser Pro Gly Ala Ser Gly Pro Asp Arg Arg Pro Arg Pro Leu Pro 
            500                 505                 510         


Pro Asp Glu Leu Ala Asn Leu Pro Lys Ala Ala Arg Leu Cys Ala Ile 
        515                 520                 525             


Ala Asp Asn Ala Val Ile Ser Ala Leu His Gly Arg Pro Glu Leu Ala 
    530                 535                 540                 


Ser Ala Glu Ala Glu Asn Val Leu Lys Gln Ala Asp Ser Ala Ala Asp 
545                 550                 555                 560 


Gly Ala Thr Ala Leu Ser Ala Leu Thr Ala Leu Leu Tyr Ala Glu Asn 
                565                 570                 575     


Thr Asp Thr Ala Gln Leu Trp Ala Asp Lys Leu Val Ser Glu Thr Gly 
            580                 585                 590         


Ala Ser Asn Glu Glu Glu Gly Ala Gly Tyr Ala Gly Pro Arg Ala Glu 
        595                 600                 605             


Thr Ala Leu Arg Arg Gly Asp Leu Ala Ala Ala Val Glu Ala Gly Ser 
    610                 615                 620                 


Ala Ile Leu Asp His Arg Arg Gly Ser Leu Leu Gly Ile Thr Ala Ala 
625                 630                 635                 640 


Leu Pro Leu Ser Ser Ala Val Ala Ala Ala Ile Arg Leu Gly Glu Thr 
                645                 650                 655     


Glu Arg Ala Glu Lys Trp Leu Ala Glu Pro Leu Pro Glu Ala Ile Arg 
            660                 665                 670         


Asp Ser Leu Phe Gly Leu His Leu Leu Ser Ala Arg Gly Gln Tyr Cys 
        675                 680                 685             


Leu Ala Thr Gly Arg His Glu Ser Ala Tyr Thr Ala Phe Arg Thr Cys 
    690                 695                 700                 


Gly Glu Arg Met Arg Asn Trp Gly Val Asp Val Pro Gly Leu Ser Leu 
705                 710                 715                 720 


Trp Arg Val Asp Ala Ala Glu Ala Leu Leu His Gly Arg Asp Arg Asp 
                725                 730                 735     


Glu Gly Arg Arg Leu Ile Asp Glu Gln Leu Thr His Ala Met Gly Pro 
            740                 745                 750         


Arg Ser Arg Ala Leu Thr Leu Arg Val Gln Ala Ala Tyr Ser Pro Gln 
        755                 760                 765             


Ala Gln Arg Val Asp Leu Leu Glu Glu Ala Ala Asp Leu Leu Leu Ser 
    770                 775                 780                 


Cys Asn Asp Gln Tyr Glu Arg Ala Arg Val Leu Ala Asp Leu Ser Glu 
785                 790                 795                 800 


Ala Phe Ser Ala Leu Arg His His Ser Arg Ala Arg Gly Leu Leu Arg 
                805                 810                 815     


Gln Ala Arg His Leu Ala Ala Gln Cys Gly Ala Thr Pro Leu Leu Arg 
            820                 825                 830         


Arg Leu Gly Ala Lys Pro Gly Gly Pro Gly Trp Leu Glu Glu Ser Gly 
        835                 840                 845             


Leu Pro Gln Arg Ile Lys Ser Leu Thr Asp Ala Glu Arg Arg Val Ala 
    850                 855                 860                 


Ser Leu Ala Ala Gly Gly Gln Thr Asn Arg Val Ile Ala Asp Gln Leu 
865                 870                 875                 880 


Phe Val Thr Ala Ser Thr Val Glu Gln His Leu Thr Asn Val Phe Arg 
                885                 890                 895     


Lys Leu Gly Val Lys Gly Arg Gln His Leu Pro Ala Glu Leu Ala Asn 
            900                 905                 910         


Ala Glu 
        


<210>  199
<211>  875
<212>  PRT
<213>  Actinoplanes sp. N01-109

<400>  199

Met Pro Ala Val Lys Arg Asn Asp Leu Val Ala Arg Asp Gly Glu Leu 
1               5                   10                  15      


Arg Trp Met Gln Glu Ile Leu Ser Gln Ala Ser Glu Gly Arg Gly Ala 
            20                  25                  30          


Val Val Thr Ile Thr Gly Ala Ile Ala Cys Gly Lys Thr Val Leu Leu 
        35                  40                  45              


Asp Ala Ala Ala Ala Ser Gln Asp Val Ile Gln Leu Arg Ala Val Cys 
    50                  55                  60                  


Ser Ala Glu Glu Gln Glu Leu Pro Tyr Ala Met Val Gly Gln Leu Leu 
65                  70                  75                  80  


Asp Asn Pro Val Leu Ala Ala Arg Val Pro Ala Leu Gly Asn Leu Ala 
                85                  90                  95      


Ala Ala Gly Glu Arg Leu Leu Pro Gly Thr Glu Asn Arg Ile Arg Arg 
            100                 105                 110         


Glu Leu Thr Arg Thr Leu Leu Ala Leu Ala Asp Glu Arg Pro Val Leu 
        115                 120                 125             


Ile Gly Val Asp Asp Met His His Ala Asp Pro Ala Ser Leu Asp Cys 
    130                 135                 140                 


Leu Leu His Leu Ala Arg Arg Val Gly Pro Ala Arg Ile Ala Ile Val 
145                 150                 155                 160 


Leu Thr Glu Leu Arg Arg Leu Thr Pro Ala His Ser Arg Phe Gln Ser 
                165                 170                 175     


Glu Leu Leu Ser Leu Arg Tyr His His Glu Ile Gly Leu Gln Pro Leu 
            180                 185                 190         


Thr Ala Glu His Thr Ala Asp Leu Ala Arg Val Gly Leu Gly Ala Glu 
        195                 200                 205             


Val Asp Asp Asp Val Leu Thr Glu Leu Tyr Glu Ala Thr Gly Gly Asn 
    210                 215                 220                 


Pro Ser Leu Cys Cys Gly Leu Ile Arg Asp Val Arg Gln Asp Trp Glu 
225                 230                 235                 240 


Ala Gly Val Thr Gly Ile His Val Gly Arg Ala Tyr Arg Leu Ala Tyr 
                245                 250                 255     


Leu Ser Ser Leu Tyr Arg Cys Gly Pro Ala Ala Leu Arg Thr Ala Arg 
            260                 265                 270         


Ala Ala Ala Val Leu Gly Asp Ser Ala Asp Ala Cys Leu Ile Arg Arg 
        275                 280                 285             


Val Ser Gly Leu Gly Thr Glu Ala Val Gly Gln Ala Ile Gln Gln Leu 
    290                 295                 300                 


Thr Glu Gly Gly Leu Leu Arg Asp Gln Gln Phe Pro His Pro Ala Ala 
305                 310                 315                 320 


Arg Ser Val Val Leu Asp Asp Met Ser Ala Gln Glu Arg His Ala Met 
                325                 330                 335     


Tyr Arg Ser Ala Arg Glu Ala Ala Ala Glu Gly Gln Ala Asp Pro Gly 
            340                 345                 350         


Thr Pro Gly Glu Pro Arg Ala Ala Thr Ala Tyr Ala Gly Cys Gly Glu 
        355                 360                 365             


Gln Ala Gly Asp Tyr Pro Glu Pro Ala Gly Arg Ala Cys Val Asp Gly 
    370                 375                 380                 


Ala Gly Pro Ala Glu Tyr Cys Gly Asp Pro His Gly Ala Asp Asp Asp 
385                 390                 395                 400 


Pro Asp Glu Leu Val Ala Ala Leu Gly Gly Leu Leu Pro Ser Arg Leu 
                405                 410                 415     


Val Ala Met Lys Ile Arg Arg Leu Ala Val Ala Gly Arg Pro Gly Ala 
            420                 425                 430         


Ala Ala Glu Leu Leu Thr Ser Gln Arg Leu His Ala Val Thr Ser Glu 
        435                 440                 445             


Asp Arg Ala Ser Leu Arg Ala Ala Glu Val Ala Leu Ala Thr Leu Trp 
    450                 455                 460                 


Pro Gly Ala Thr Gly Pro Asp Arg His Pro Leu Thr Glu Gln Glu Ala 
465                 470                 475                 480 


Ala Ser Leu Pro Glu Gly Pro Arg Leu Leu Ala Ala Ala Asp Asp Ala 
                485                 490                 495     


Val Gly Ala Ala Leu Arg Gly Arg Ala Glu Tyr Ala Ala Ala Glu Ala 
            500                 505                 510         


Glu Asn Val Leu Arg His Ala Asp Pro Ala Ala Gly Gly Asp Ala Tyr 
        515                 520                 525             


Ala Ala Met Ile Ala Leu Leu Tyr Thr Glu His Pro Glu Asn Val Leu 
    530                 535                 540                 


Phe Trp Ala Asp Lys Leu Asp Ala Gly Arg Pro Asp Glu Glu Thr Ser 
545                 550                 555                 560 


Tyr Pro Gly Leu Arg Ala Glu Thr Ala Val Arg Leu Gly Asp Leu Glu 
                565                 570                 575     


Thr Ala Met Glu Leu Gly Arg Thr Val Leu Asp Gln Arg Arg Leu Pro 
            580                 585                 590         


Ser Leu Gly Val Ala Ala Gly Leu Leu Leu Gly Gly Ala Val Thr Ala 
        595                 600                 605             


Ala Ile Arg Leu Gly Asp Leu Asp Arg Ala Glu Lys Trp Leu Ala Glu 
    610                 615                 620                 


Pro Ile Pro Asp Ala Ile Arg Thr Ser Leu Tyr Gly Leu His Val Leu 
625                 630                 635                 640 


Ala Ala Arg Gly Arg Leu Asp Leu Ala Ala Gly Arg Tyr Glu Ala Ala 
                645                 650                 655     


Tyr Thr Ala Phe Arg Leu Cys Gly Glu Arg Met Ala Gly Trp Asp Ala 
            660                 665                 670         


Asp Val Ser Gly Leu Ala Leu Trp Arg Val Asp Ala Ala Glu Ala Leu 
        675                 680                 685             


Leu Ser Ala Gly Ile Arg Pro Asp Glu Gly Arg Lys Leu Ile Asp Asp 
    690                 695                 700                 


Gln Leu Thr Arg Glu Met Gly Ala Arg Ser Arg Ala Leu Thr Leu Arg 
705                 710                 715                 720 


Ala Gln Ala Ala Tyr Ser Leu Pro Val His Arg Val Gly Leu Leu Asp 
                725                 730                 735     


Glu Ala Ala Gly Leu Leu Leu Ala Cys His Asp Gly Tyr Glu Arg Ala 
            740                 745                 750         


Arg Val Leu Ala Asp Leu Gly Glu Thr Leu Arg Thr Leu Arg His Thr 
        755                 760                 765             


Asp Ala Ala Gln Arg Val Leu Arg Gln Ala Glu Gln Ala Ala Ala Arg 
    770                 775                 780                 


Cys Gly Ser Val Pro Leu Leu Arg Arg Leu Gly Ala Glu Pro Val Arg 
785                 790                 795                 800 


Ile Gly Thr Arg Arg Gly Glu Pro Gly Leu Pro Gln Arg Ile Arg Leu 
                805                 810                 815     


Leu Thr Asp Ala Glu Arg Arg Val Ala Ala Met Ala Ala Ala Gly Gln 
            820                 825                 830         


Thr Asn Arg Glu Ile Ala Gly Arg Leu Phe Val Thr Ala Ser Thr Val 
        835                 840                 845             


Glu Gln His Leu Thr Ser Val Phe Arg Lys Leu Gly Val Lys Gly Arg 
    850                 855                 860                 


Arg Phe Leu Pro Thr Glu Leu Ala Gln Ala Val 
865                 870                 875 


<210>  200
<211>  906
<212>  PRT
<213>  Streptomyces malaysiensis

<400>  200

Met Tyr Ser Gly Thr Cys Arg Glu Gly Tyr Glu Leu Val Ala Arg Glu 
1               5                   10                  15      


Asp Glu Leu Gly Ile Leu Gln Arg Ser Leu Glu Gln Ala Ser Ser Gly 
            20                  25                  30          


Gln Gly Val Val Val Thr Val Thr Gly Pro Ile Ala Cys Gly Lys Thr 
        35                  40                  45              


Glu Leu Leu Asp Ala Ala Ala Ala Lys Ala Glu Ala Ile Ile Leu Arg 
    50                  55                  60                  


Ala Val Cys Ala Pro Glu Glu Arg Ala Met Pro Tyr Ala Met Ile Gly 
65                  70                  75                  80  


Gln Leu Ile Asp Asp Pro Ala Leu Ala His Arg Ala Pro Gly Leu Ala 
                85                  90                  95      


Asp Arg Ile Ala Gln Gly Gly Gln Leu Ser Leu Arg Ala Glu Asn Arg 
            100                 105                 110         


Leu Arg Arg Asp Leu Thr Arg Ala Leu Leu Ala Leu Ala Val Asp Arg 
        115                 120                 125             


Pro Val Leu Ile Gly Val Asp Asp Val His His Ala Asp Thr Ala Ser 
    130                 135                 140                 


Leu Asn Cys Leu Leu His Leu Ala Arg Arg Val Arg Pro Ala Arg Ile 
145                 150                 155                 160 


Ser Met Ile Phe Thr Glu Leu Arg Ser Leu Thr Pro Thr Gln Ser Arg 
                165                 170                 175     


Phe Lys Ala Glu Leu Leu Ser Leu Pro Tyr His His Glu Ile Ala Leu 
            180                 185                 190         


Arg Pro Phe Gly Pro Glu Gln Ser Ala Glu Leu Ala Arg Ala Ala Phe 
        195                 200                 205             


Gly Pro Gly Leu Ala Glu Asp Val Leu Ala Gly Leu Tyr Lys Thr Thr 
    210                 215                 220                 


Arg Gly Asn Leu Ser Leu Ser Arg Gly Leu Ile Ser Asp Val Arg Glu 
225                 230                 235                 240 


Ala Leu Ala Asn Gly Glu Ser Ala Phe Glu Ala Gly Arg Ala Phe Arg 
                245                 250                 255     


Leu Ala Tyr Leu Ser Ser Leu Tyr Arg Cys Gly Pro Val Ala Leu Arg 
            260                 265                 270         


Val Ala Arg Val Ala Ala Val Leu Gly Pro Ser Ala Thr Thr Thr Leu 
        275                 280                 285             


Val Arg Arg Leu Ser Gly Leu Ser Ala Glu Thr Ile Asp Arg Ala Thr 
    290                 295                 300                 


Lys Ile Leu Thr Glu Gly Gly Leu Leu Leu Asp Gln Gln Phe Pro His 
305                 310                 315                 320 


Pro Ala Ala Arg Ser Val Val Leu Asp Asp Met Ser Ala Gln Glu Arg 
                325                 330                 335     


Arg Ser Leu His Thr Leu Ala Leu Glu Leu Leu Asp Glu Ala Pro Val 
            340                 345                 350         


Glu Val Leu Ala His His Gln Val Gly Ala Gly Leu Ile His Gly Pro 
        355                 360                 365             


Lys Ala Ala Glu Met Phe Ala Lys Ala Gly Lys Ala Leu Val Val Arg 
    370                 375                 380                 


Asn Glu Leu Gly Asp Ala Ala Glu Tyr Leu Gln Leu Ala His Arg Ala 
385                 390                 395                 400 


Ser Asp Asp Val Ser Thr Arg Ala Ala Leu Arg Val Glu Ala Val Ala 
                405                 410                 415     


Ile Glu Arg Arg Arg Asn Pro Leu Ala Ser Ser Arg His Met Asp Glu 
            420                 425                 430         


Leu Ser Ala Ala Gly Arg Ala Gly Leu Leu Ser Pro Lys His Ala Ala 
        435                 440                 445             


Leu Ala Val Phe Trp Leu Ala Asp Gly Gly Arg Ser Gly Glu Ala Ala 
    450                 455                 460                 


Glu Val Leu Ala Ser Glu Arg Pro Leu Ala Thr Thr Asp Gln Asn Arg 
465                 470                 475                 480 


Ala His Leu Arg Phe Val Glu Val Thr Leu Ala Leu Phe Ser Pro Gly 
                485                 490                 495     


Ala Phe Gly Ser Asp Arg Arg Pro Pro Pro Leu Thr Pro Asp Glu Leu 
            500                 505                 510         


Ala Ser Leu Pro Lys Ala Ala Trp Gln Cys Ala Val Ala Asp Asn Ala 
        515                 520                 525             


Ala Met Thr Ala Leu His Gly His Pro Glu Leu Ala Thr Ala Gln Ala 
    530                 535                 540                 


Glu Thr Val Leu Arg Gln Ala Asp Ser Ala Ala Asp Ala Ile Pro Ala 
545                 550                 555                 560 


Ala Leu Ile Ala Leu Leu Tyr Ala Glu Asn Thr Glu Ser Ala His Ile 
                565                 570                 575     


Trp Ala Asp Lys Leu Gly Ser Thr Asn Ala Gly Val Ser Asn Glu Ala 
            580                 585                 590         


Glu Ala Gly Tyr Ala Gly Pro Cys Ala Glu Ile Ala Leu Arg Arg Gly 
        595                 600                 605             


Asp Leu Ala Thr Ala Phe Glu Ala Gly Ser Ala Val Leu Asp Asp Arg 
    610                 615                 620                 


Ser Leu Pro Ser Leu Gly Ile Thr Ala Ala Leu Leu Leu Ser Ser Lys 
625                 630                 635                 640 


Thr Ala Ala Ala Val Arg Leu Gly Glu Leu Glu Arg Ala Glu Lys Leu 
                645                 650                 655     


Leu Ala Glu Pro Leu Pro Asn Gly Val Gln Asp Ser Leu Phe Gly Leu 
            660                 665                 670         


His Leu Leu Ser Ala Tyr Gly Gln Tyr Ser Leu Ala Met Gly Arg Tyr 
        675                 680                 685             


Glu Ser Ala His Arg Ala Phe Arg Thr Cys Gly Glu Arg Met Arg Ser 
    690                 695                 700                 


Trp Asp Val Asp Val Pro Gly Leu Ala Leu Trp Arg Val Asp Ala Ala 
705                 710                 715                 720 


Glu Ala Leu Leu Ser Leu Asp Arg Asn Glu Gly Gln Arg Leu Ile Asp 
                725                 730                 735     


Glu Gln Leu Thr Arg Pro Met Gly Pro Arg Ser His Ala Leu Thr Leu 
            740                 745                 750         


Arg Ile Lys Ala Ala Tyr Leu Pro Arg Thr Lys Arg Ile Pro Leu Leu 
        755                 760                 765             


His Glu Ala Ala Glu Leu Leu Leu Pro Cys Pro Asp Pro Tyr Glu Gln 
    770                 775                 780                 


Ala Arg Val Leu Ala Asp Leu Gly Asp Thr Leu Ser Ala Leu Arg Arg 
785                 790                 795                 800 


Tyr Ser Arg Ala Arg Gly Val Leu Arg Gln Ala Arg His Leu Ala Thr 
                805                 810                 815     


Gln Cys Gly Ala Val Pro Leu Leu Arg Arg Leu Gly Gly Glu Pro Gly 
            820                 825                 830         


Arg Ile Asp Asp Ala Gly Leu Pro Gln Arg Ser Thr Ser Leu Thr Asp 
        835                 840                 845             


Ala Glu Arg Arg Val Ala Ala Leu Ala Ala Ala Gly Gln Thr Asn Arg 
    850                 855                 860                 


Glu Ile Ala Glu Gln Leu Phe Val Thr Ala Ser Thr Val Glu Gln His 
865                 870                 875                 880 


Leu Thr Ser Val Phe Arg Lys Leu Gly Val Lys Gly Arg Lys Gln Leu 
                885                 890                 895     


Pro Thr Ala Leu Ala Asp Val Glu Gln Thr 
            900                 905     


<210>  201
<211>  904
<212>  PRT
<213>  Streptomyces violaceusniger

<400>  201

Met Tyr Ser Gly Thr Cys Arg Glu Gly Tyr Glu Leu Val Ala Arg Glu 
1               5                   10                  15      


Asp Glu Leu Gly Ile Leu Gln Arg Ser Leu Glu Glu Ala Gly Ser Gly 
            20                  25                  30          


Gln Gly Ala Val Val Thr Val Thr Gly Pro Ile Ala Cys Gly Lys Thr 
        35                  40                  45              


Glu Leu Leu Asp Ala Ala Ala Ala Lys Ala Asp Ala Ile Ile Leu Arg 
    50                  55                  60                  


Ala Val Cys Ala Pro Glu Glu Arg Ala Met Pro Tyr Ala Met Ile Gly 
65                  70                  75                  80  


Gln Leu Ile Asp Asp Pro Ala Leu Ala His Arg Ala Pro Glu Leu Ala 
                85                  90                  95      


Asp Arg Ile Ala Gln Gly Gly His Leu Ser Leu Arg Ala Glu Asn Arg 
            100                 105                 110         


Leu Arg Arg Asp Leu Thr Arg Ala Leu Leu Ala Leu Ala Val Asp Arg 
        115                 120                 125             


Pro Val Leu Ile Gly Val Asp Asp Val His His Ala Asp Thr Ala Ser 
    130                 135                 140                 


Leu Asn Cys Leu Leu His Leu Ala Arg Arg Val Arg Pro Ala Arg Ile 
145                 150                 155                 160 


Ser Met Ile Phe Thr Glu Leu Arg Ser Leu Thr Pro Thr Gln Ser Arg 
                165                 170                 175     


Phe Lys Ala Glu Leu Leu Ser Leu Pro Tyr His His Glu Ile Ala Leu 
            180                 185                 190         


Arg Pro Leu Gly Pro Glu Gln Ser Ala Glu Leu Ala His Ala Ala Phe 
        195                 200                 205             


Gly Pro Gly Leu Ala Glu Asp Val Leu Ala Gly Leu Tyr Gly Met Thr 
    210                 215                 220                 


Arg Gly Asn Leu Ser Leu Ser Arg Gly Leu Ile Ser Asp Val Arg Glu 
225                 230                 235                 240 


Ala Gln Ala Asn Gly Glu Ser Ala Phe Glu Val Gly Arg Ala Phe Arg 
                245                 250                 255     


Leu Ala Tyr Leu Ser Ser Leu Tyr Arg Cys Gly Pro Ile Ala Leu Arg 
            260                 265                 270         


Val Ala Arg Val Ala Ala Val Leu Gly Pro Ser Ala Thr Thr Thr Leu 
        275                 280                 285             


Val Arg Arg Leu Ser Gly Leu Ser Ala Glu Thr Ile Asp Arg Ala Thr 
    290                 295                 300                 


Lys Ile Leu Thr Glu Gly Gly Leu Leu Leu Asp His Gln Phe Pro His 
305                 310                 315                 320 


Pro Ala Ala Arg Ser Val Val Leu Asp Asp Met Ser Ala Gln Glu Arg 
                325                 330                 335     


Arg Ser Leu His Thr Leu Ala Leu Glu Leu Leu Asp Glu Ala Pro Val 
            340                 345                 350         


Glu Val Leu Ala His His Gln Val Gly Ala Gly Leu Ile His Gly Pro 
        355                 360                 365             


Lys Ala Ala Glu Ile Phe Ala Arg Ala Gly Gln Ala Leu Val Val Arg 
    370                 375                 380                 


Asn Glu Leu Gly Asp Ala Ala Glu Tyr Leu Gln Leu Ala His Arg Ala 
385                 390                 395                 400 


Ser Asp Asp Val Ser Thr Arg Ala Ala Leu Arg Val Glu Ala Val Ala 
                405                 410                 415     


Ile Glu Arg Arg Arg Asn Pro Leu Ala Ser Ser Arg His Met Asp Glu 
            420                 425                 430         


Leu Ser Ala Ala Gly Arg Ala Gly Leu Leu Ser Pro Lys His Ala Ala 
        435                 440                 445             


Leu Ala Val Phe Trp Leu Ala Asp Gly Gly Arg Ser Gly Glu Ala Ala 
    450                 455                 460                 


Glu Val Leu Ala Ser Glu His Pro Leu Ala Thr Thr Asp Gln Asn Arg 
465                 470                 475                 480 


Ala His Leu Arg Phe Ala Glu Val Thr Leu Ala Leu Phe Cys Pro Gly 
                485                 490                 495     


Ala Phe Gly Ser Asp Arg Arg Pro Pro Pro Leu Ala Pro Asp Glu Leu 
            500                 505                 510         


Ala Ser Leu Pro Lys Ala Ala Trp Gln Cys Ala Val Ala Asp Asn Ala 
        515                 520                 525             


Val Met Thr Ala Leu His Ala His Pro Glu Leu Ala Thr Ala Gln Ala 
    530                 535                 540                 


Glu Thr Val Leu Arg Gln Ala Asp Ser Ala Ala Asp Ala Ile Pro Ala 
545                 550                 555                 560 


Ala Leu Ile Ala Leu Leu Tyr Ala Glu Asn Thr Glu Ser Ala Gln Ile 
                565                 570                 575     


Trp Ala Asp Lys Leu Gly Ser Thr Asn Ala Gly Val Ser Asn Glu Ala 
            580                 585                 590         


Glu Ala Gly Tyr Ala Gly Pro Cys Ala Glu Ile Ala Leu Arg Arg Gly 
        595                 600                 605             


Asp Leu Ala Thr Ala Phe Glu Ala Gly Gly Thr Val Leu Asp Asp Arg 
    610                 615                 620                 


Pro Leu Pro Ser Leu Gly Ile Thr Ala Ala Leu Leu Leu Ser Ser Lys 
625                 630                 635                 640 


Thr Ala Ala Ala Val Arg Leu Gly Glu Leu Glu Arg Ala Glu Lys Leu 
                645                 650                 655     


Leu Ala Glu Pro Leu Pro Asn Gly Val Gln Asp Ser Leu Phe Gly Leu 
            660                 665                 670         


His Leu Leu Ser Ala His Gly Gln Tyr Ser Leu Ala Met Gly Arg Tyr 
        675                 680                 685             


Glu Ser Ala His Arg Ala Phe His Thr Cys Gly Glu Arg Met Arg Ser 
    690                 695                 700                 


Trp Gly Val Asp Val Pro Gly Leu Ala Leu Trp Arg Val Asp Ala Ala 
705                 710                 715                 720 


Glu Ala Leu Leu Ser Leu Asp Arg Asn Glu Gly Gln Arg Leu Ile Asp 
                725                 730                 735     


Glu Gln Leu Ala Arg Pro Met Gly Pro Arg Ser Arg Ala Leu Thr Leu 
            740                 745                 750         


Arg Ile Lys Ala Ala Tyr Leu Pro Arg Thr Lys Arg Ile Pro Leu Leu 
        755                 760                 765             


His Glu Ala Ala Glu Leu Leu Leu Ser Cys Pro Asp Pro Tyr Glu Gln 
    770                 775                 780                 


Ala Arg Val Leu Ala Asp Leu Gly Asp Thr Leu Ser Ala Leu Arg Arg 
785                 790                 795                 800 


Tyr Ser Arg Ala Arg Gly Val Leu Arg Gln Ala Arg His Leu Ala Thr 
                805                 810                 815     


Gln Cys Gly Ala Val Pro Leu Leu Arg Arg Leu Gly Gly Glu Pro Gly 
            820                 825                 830         


Arg Ile Asp Asp Ala Gly Leu Pro Gln Arg Ser Thr Ser Leu Thr Asp 
        835                 840                 845             


Ala Glu Arg Arg Val Ser Ala Leu Ala Ala Ala Gly Gln Thr Asn Arg 
    850                 855                 860                 


Glu Ile Ala Lys Gln Leu Phe Val Thr Ala Ser Thr Val Glu Gln His 
865                 870                 875                 880 


Leu Thr Ser Val Phe Arg Lys Leu Gly Val Lys Gly Arg Arg Gln Leu 
                885                 890                 895     


Pro Thr Ala Leu Ala Asp Val Glu 
            900                 


<210>  202
<211>  906
<212>  PRT
<213>  Streptomyces Sp. NRRL F-4729

<400>  202

Met Tyr Ser Gly Thr Cys Arg Glu Gly Tyr Glu Leu Val Ala Arg Glu 
1               5                   10                  15      


Asp Glu Leu Gly Ile Leu Gln Arg Ser Leu Glu Gln Ala Ser Ser Gly 
            20                  25                  30          


Gln Gly Val Val Val Thr Val Thr Gly Pro Ile Ala Cys Gly Lys Thr 
        35                  40                  45              


Glu Leu Leu Asp Ala Ala Ala Ala Lys Ala Glu Ala Ile Ile Leu Arg 
    50                  55                  60                  


Ala Val Cys Ala Pro Glu Glu Arg Ala Met Pro Tyr Ala Met Ile Gly 
65                  70                  75                  80  


Gln Leu Ile Asp Asp Pro Ala Leu Ala His Arg Ala Pro Gly Leu Ala 
                85                  90                  95      


Asp Arg Ile Ala Gln Gly Gly Gln Leu Ser Leu Arg Ala Glu Asn Arg 
            100                 105                 110         


Leu Arg Arg Asp Leu Thr Arg Ala Leu Leu Ala Leu Ala Val His Arg 
        115                 120                 125             


Pro Val Leu Ile Gly Val Asp Asp Val His His Ala Asp Thr Ala Ser 
    130                 135                 140                 


Leu Asn Cys Leu Leu His Leu Ala Arg Arg Val Arg Pro Ala Arg Ile 
145                 150                 155                 160 


Ser Met Ile Phe Thr Glu Leu Arg Ser Leu Thr Pro Thr Gln Ser Arg 
                165                 170                 175     


Phe Lys Ala Glu Leu Leu Ser Leu Pro Tyr His His Glu Ile Ala Leu 
            180                 185                 190         


Arg Pro Phe Gly Pro Glu Gln Ser Ala Glu Leu Ala Arg Ala Ala Phe 
        195                 200                 205             


Gly Pro Gly Leu Ala Glu Asp Val Leu Ala Gly Leu Tyr Lys Thr Thr 
    210                 215                 220                 


Arg Gly Asn Leu Ser Leu Ser Arg Gly Leu Ile Ser Asp Val Arg Glu 
225                 230                 235                 240 


Ala Leu Ala Asn Gly Glu Ser Ala Phe Glu Ala Gly Arg Ala Phe Arg 
                245                 250                 255     


Leu Ala Tyr Leu Ser Ser Leu Tyr Arg Cys Gly Pro Val Ala Leu Arg 
            260                 265                 270         


Val Ala Arg Val Ala Ala Val Leu Gly Pro Ser Ala Thr Thr Thr Leu 
        275                 280                 285             


Val Arg Arg Leu Ser Gly Leu Ser Ala Glu Thr Ile Asp Arg Ala Thr 
    290                 295                 300                 


Lys Ile Leu Thr Glu Gly Gly Leu Leu Leu Asp Gln Gln Phe Pro His 
305                 310                 315                 320 


Pro Ala Ala Arg Ser Val Val Leu Asp Asp Met Ser Ala Gln Glu Arg 
                325                 330                 335     


Arg Gly Leu His Thr Leu Ala Leu Glu Leu Leu Asp Glu Ala Pro Val 
            340                 345                 350         


Glu Val Leu Ala His His Gln Val Gly Ala Gly Leu Ile His Gly Pro 
        355                 360                 365             


Lys Ala Ala Glu Met Phe Ala Lys Ala Gly Lys Ala Leu Val Val Arg 
    370                 375                 380                 


Asn Glu Leu Gly Asp Ala Ala Glu Tyr Leu Gln Leu Ala His Arg Ala 
385                 390                 395                 400 


Ser Asp Asp Val Ser Thr Arg Ala Ala Leu Arg Val Glu Ala Val Ala 
                405                 410                 415     


Ile Glu Arg Arg Arg Asn Pro Leu Ala Ser Ser Arg His Met Asp Glu 
            420                 425                 430         


Leu Ser Ala Ala Gly Arg Ala Gly Leu Leu Ser Pro Lys His Ala Ala 
        435                 440                 445             


Leu Ala Val Phe Trp Leu Ala Asp Gly Gly Arg Ser Gly Glu Ala Ala 
    450                 455                 460                 


Gln Val Leu Ala Ser Glu Arg Pro Leu Ala Thr Thr Asp Gln Asn Arg 
465                 470                 475                 480 


Ala His Leu Arg Phe Val Glu Val Thr Leu Ala Leu Phe Ser Pro Gly 
                485                 490                 495     


Ala Phe Gly Ser Asp Arg Arg Pro Pro Pro Leu Thr Pro Asp Glu Leu 
            500                 505                 510         


Ala Ser Leu Pro Lys Ala Ala Trp Gln Cys Ala Val Ala Asp Asn Ala 
        515                 520                 525             


Ala Met Thr Ala Leu His Gly His Pro Glu Leu Ala Thr Ala Gln Ala 
    530                 535                 540                 


Glu Thr Val Leu Arg Gln Ala Asp Ser Ala Ala Asp Ala Ile Pro Ala 
545                 550                 555                 560 


Ala Leu Ile Ala Leu Leu Tyr Ala Glu Asn Thr Glu Ser Ala His Ile 
                565                 570                 575     


Trp Ala Asp Lys Leu Gly Ser Met Asn Ala Gly Val Ser Asn Glu Ala 
            580                 585                 590         


Glu Ala Gly Tyr Ala Gly Pro Cys Ala Glu Ile Ala Leu Arg Arg Gly 
        595                 600                 605             


Asp Leu Ala Thr Ala Phe Glu Ala Gly Ser Thr Val Leu Asp Asp Arg 
    610                 615                 620                 


Ser Leu Pro Ser Leu Gly Ile Thr Ala Ala Leu Leu Leu Ser Ser Lys 
625                 630                 635                 640 


Thr Ala Ala Ala Val Arg Leu Gly Glu Leu Glu Arg Ala Glu Lys Leu 
                645                 650                 655     


Leu Ala Glu Pro Leu Pro Asn Gly Val Gln Asp Ser Leu Phe Gly Leu 
            660                 665                 670         


His Leu Leu Ser Ala Tyr Gly Gln Tyr Ser Leu Ala Met Gly Arg Tyr 
        675                 680                 685             


Glu Ser Ala His Arg Ala Phe Arg Thr Cys Gly Glu Arg Met Arg Ser 
    690                 695                 700                 


Trp Asp Val Asp Val Pro Gly Leu Ala Leu Trp Arg Val Asp Ala Ala 
705                 710                 715                 720 


Glu Ala Leu Leu Ser Leu Asp Arg Asn Glu Gly Gln Arg Leu Ile Asp 
                725                 730                 735     


Glu Gln Leu Thr Arg Pro Met Gly Pro Arg Ser Arg Ala Leu Thr Leu 
            740                 745                 750         


Arg Ile Lys Ala Ala Tyr Leu Pro Arg Thr Lys Arg Ile Pro Leu Leu 
        755                 760                 765             


His Glu Ala Ala Glu Leu Leu Leu Pro Cys Pro Asp Pro Tyr Glu Gln 
    770                 775                 780                 


Ala Arg Val Leu Ala Asp Leu Gly Asp Thr Leu Ser Ala Leu Arg Arg 
785                 790                 795                 800 


Tyr Ser Arg Ala Arg Gly Val Leu Arg Gln Ala Arg His Leu Ala Thr 
                805                 810                 815     


Gln Cys Gly Ala Val Pro Leu Leu Arg Arg Leu Gly Gly Glu Pro Gly 
            820                 825                 830         


Arg Ile Asp Asp Ala Gly Leu Pro Gln Arg Ser Thr Ser Leu Thr Asp 
        835                 840                 845             


Ala Glu Arg Arg Val Ala Ala Leu Ala Ala Ala Gly Gln Thr Asn Arg 
    850                 855                 860                 


Glu Ile Ala Glu Gln Leu Phe Val Thr Ala Ser Thr Val Glu Gln His 
865                 870                 875                 880 


Leu Thr Ser Val Phe Arg Lys Leu Gly Val Lys Gly Arg Lys Gln Leu 
                885                 890                 895     


Pro Thr Ala Leu Ala Asp Val Glu Gln Thr 
            900                 905     


<210>  203
<211>  904
<212>  PRT
<213>  Streptomyces filamentosus

<400>  203

Met Arg Ala Ile Asn Ala Ser Asp Thr Gly Pro Glu Leu Val Ala Arg 
1               5                   10                  15      


Glu Asp Glu Leu Gly Arg Val Arg Ser Ala Leu Asn Arg Ala Asn Gly 
            20                  25                  30          


Gly Gln Gly Val Leu Ile Ser Ile Thr Gly Pro Ile Ala Cys Gly Lys 
        35                  40                  45              


Thr Glu Leu Leu Glu Ala Ala Ala Ser Glu Val Asp Ala Ile Thr Leu 
    50                  55                  60                  


Arg Ala Val Cys Ala Ala Glu Glu Arg Ala Ile Pro Tyr Ala Leu Ile 
65                  70                  75                  80  


Gly Gln Leu Ile Asp Asn Pro Ala Leu Gly Ile Pro Val Pro Asp Pro 
                85                  90                  95      


Ala Gly Leu Thr Ala Gln Gly Gly Arg Leu Ser Ser Ser Ala Glu Asn 
            100                 105                 110         


Arg Leu Arg Arg Asp Leu Thr Arg Ala Leu Leu Thr Leu Ala Thr Asp 
        115                 120                 125             


Arg Leu Val Leu Ile Cys Val Asp Asp Val Gln His Ala Asp Asn Ala 
    130                 135                 140                 


Ser Leu Ser Cys Leu Leu Tyr Leu Ala Arg Arg Leu Val Pro Ala Arg 
145                 150                 155                 160 


Ile Ala Leu Val Phe Thr Glu Leu Arg Val Leu Thr Ser Ser Gln Leu 
                165                 170                 175     


Arg Phe Asn Ala Glu Leu Leu Ser Leu Arg Asn His Cys Glu Ile Ala 
            180                 185                 190         


Leu Arg Pro Leu Gly Pro Gly His Ala Ala Glu Leu Ala Arg Ala Thr 
        195                 200                 205             


Leu Gly Pro Gly Leu Ser Asp Glu Thr Leu Thr Glu Leu Tyr Arg Val 
    210                 215                 220                 


Thr Gly Gly Asn Leu Ser Leu Ser Arg Gly Leu Ile Asp Asp Val Arg 
225                 230                 235                 240 


Asp Ala Trp Ala Arg Gly Glu Thr Gly Val Gln Val Gly Arg Ala Phe 
                245                 250                 255     


Arg Leu Ala Tyr Leu Gly Ser Leu His Arg Cys Gly Pro Leu Ala Leu 
            260                 265                 270         


Arg Val Ala Arg Val Ala Ala Val Leu Gly Pro Ser Ala Thr Ser Val 
        275                 280                 285             


Leu Val Arg Arg Ile Ser Gly Leu Ser Ala Glu Ala Met Ala Gln Ala 
    290                 295                 300                 


Thr Asp Ile Leu Ala Asp Gly Gly Leu Leu Arg Asp Gln Arg Phe Thr 
305                 310                 315                 320 


His Pro Ala Ala Arg Ser Val Val Leu Asp Asp Met Ser Ala Glu Glu 
                325                 330                 335     


Arg Arg Ser Val His Ser Leu Ala Leu Glu Leu Leu Asp Glu Ala Pro 
            340                 345                 350         


Ala Glu Met Leu Ala His His Arg Val Gly Ala Gly Leu Val His Gly 
        355                 360                 365             


Pro Lys Ala Ala Glu Thr Phe Thr Gly Ala Gly Arg Ala Leu Ala Val 
    370                 375                 380                 


Arg Gly Met Leu Gly Glu Ala Ala Asp Tyr Leu Gln Leu Ala Tyr Arg 
385                 390                 395                 400 


Ala Ser Gly Asp Ala Ala Thr Lys Ala Ala Ile Arg Val Glu Ser Val 
                405                 410                 415     


Ala Val Glu Arg Arg Arg Asn Pro Leu Val Val Ser Arg His Trp Asp 
            420                 425                 430         


Glu Leu Ser Val Ala Ala Arg Ala Gly Leu Leu Ser Cys Glu His Val 
        435                 440                 445             


Ser Arg Thr Ala Arg Trp Leu Thr Val Gly Gly Arg Pro Gly Glu Ala 
    450                 455                 460                 


Ala Arg Val Leu Ala Ser Gln His Arg Arg Val Val Thr Asp Gln Asp 
465                 470                 475                 480 


Arg Ala His Leu Arg Val Ala Glu Phe Ser Leu Ala Leu Leu Tyr Pro 
                485                 490                 495     


Gly Thr Ser Gly Ser Asp Arg Arg Pro His Pro Leu Thr Ser Asp Glu 
            500                 505                 510         


Leu Ala Ala Leu Pro Thr Ala Thr Arg His Cys Ala Ile Ala Asp Asn 
        515                 520                 525             


Ala Val Met Ala Ala Leu Arg Gly His Pro Glu Leu Ala Thr Ala Glu 
    530                 535                 540                 


Ala Glu Ala Val Leu Gln Gln Ala Asp Ala Ala Asp Gly Ala Ala Leu 
545                 550                 555                 560 


Thr Ala Leu Met Ala Leu Leu Tyr Ala Glu Ser Ile Glu Val Ala Glu 
                565                 570                 575     


Val Trp Ala Asp Lys Leu Ala Ala Glu Ala Gly Ala Ser Asn Gly Gln 
            580                 585                 590         


Asp Ala Glu Tyr Ala Gly Ile Arg Ala Glu Ile Ala Leu Arg Arg Gly 
        595                 600                 605             


Asp Leu Thr Ala Ala Val Glu Thr Ala Gly Met Val Leu Asp Gly Arg 
    610                 615                 620                 


Pro Leu Pro Ser Leu Asp Ile Thr Ala Thr Leu Leu Leu Ala Gly Arg 
625                 630                 635                 640 


Ala Ser Val Ala Val Arg Leu Gly Glu Leu Asp His Ala Glu Glu Leu 
                645                 650                 655     


Phe Ala Ala Pro Pro Glu Asp Ala Phe Gln Asp Ser Leu Phe Gly Leu 
            660                 665                 670         


His Leu Leu Ser Ala His Gly Gln Tyr Ser Leu Ala Thr Gly Arg Pro 
        675                 680                 685             


Glu Ser Ala Tyr Arg Ala Phe Arg Ala Cys Gly Glu Arg Met Arg Asp 
    690                 695                 700                 


Trp Gly Phe Asp Ala Pro Gly Val Ala Leu Trp Arg Val Gly Ala Ala 
705                 710                 715                 720 


Glu Ala Leu Leu Gly Leu Asp Arg Asn Glu Gly Arg Arg Leu Ile Asp 
                725                 730                 735     


Glu Gln Leu Ser Arg Thr Met Ala Pro Arg Ser His Ala Leu Thr Leu 
            740                 745                 750         


Arg Ile Lys Ala Ala Tyr Met Pro Glu Pro Lys Arg Val Asp Leu Leu 
        755                 760                 765             


Tyr Glu Ala Ala Glu Leu Leu Leu Ser Cys Arg Asp Gln Tyr Glu Arg 
    770                 775                 780                 


Ala Arg Val Leu Ala Asp Leu Gly Glu Ala Leu Ser Ala Leu Gly Asn 
785                 790                 795                 800 


Tyr Arg Gln Ala Arg Gly Val Leu Arg Gln Ala Arg His Leu Ala Met 
                805                 810                 815     


Arg Thr Gly Ala Asp Pro Leu Leu Arg Arg Leu Gly Ile Arg Pro Gly 
            820                 825                 830         


Arg Gln Asp Asp Pro Asp Pro Gln Pro Arg Ser Arg Ser Leu Thr Asn 
        835                 840                 845             


Ala Glu Arg Arg Ala Ala Ser Leu Ala Ala Thr Gly Leu Thr Asn Arg 
    850                 855                 860                 


Glu Ile Ala Asp Arg Leu Phe Val Thr Ala Ser Thr Val Glu Gln His 
865                 870                 875                 880 


Leu Thr Asn Val Phe Arg Lys Leu Gly Val Lys Gly Arg Lys Gln Leu 
                885                 890                 895     


Pro Ala Glu Leu Asp Asp Met Glu 
            900                 


<210>  204
<211>  6
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  204
aggggg                                                                   6


