                         SEQUENCE LISTING

<110>  EDITAS MEDICINE
       DUKE UNIVERSITY
       FRIEDLAND, Ari
       O'DONNELL, Penrose
       BUMCROT, David A.
       CULLEN, Bryan R.
 
<120>  CRISPR/CAS-RELATED METHODS AND COMPOSITIONS FOR TREATING HERPES 
       SIMPLEX VIRUS

<130>  084177.0134PCT

<150>  US 62/414,561
<151>  2016-10-28

<160>  39    

<170>  PatentIn version 3.5

<210>  1
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1
gcgucaucga ccucgucgga cu                                                22


<210>  2
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2
gucaucgacc ucgucggacu                                                   20


<210>  3
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  3
gggcgcggcg acaggcgguc cg                                                22


<210>  4
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  4
gcgcggcgac aggcgguccg                                                   20


<210>  5
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  5
gacgggccuc caucccgggu                                                   20


<210>  6
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  6
gcgaggucgu gaagcuggaa u                                                 21


<210>  7
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  7
gacacgcacc gccaggagug u                                                 21


<210>  8
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  8
ggaguguucg agucgugucu                                                   20


<210>  9
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  9
ggagagccgc cgcgacgacc                                                   20


<210>  10
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  10
gaccuggaau cggacagcag cg                                                22


<210>  11
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  11
gcgaccgucu ccucuaccuc                                                   20


<210>  12
<211>  24
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  12
gcccccccgg cccugagucg gagg                                              24


<210>  13
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  13
gucucuguug uuugcaaggg gg                                                22


<210>  14
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  14
ccuugugaaa caguacggcc                                                   20


<210>  15
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  15
guacggcccc gaguucguga                                                   20


<210>  16
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  16
gaggccgccg aggacgucag                                                   20


<210>  17
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  17
gccccuccgg ggggguuggg gu                                                22


<210>  18
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  18
ggggggcguc uggccccucc gg                                                22


<210>  19
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  19
ucggggccgu acuguuucac                                                   20


<210>  20
<211>  24
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  20
gguccgugcu guccgccucg gagg                                              24


<210>  21
<211>  24
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  21
gccugauagu gggcgugacg ccca                                              24


<210>  22
<211>  24
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  22
gucaucgucg ucggcucgaa aggc                                              24


<210>  23
<211>  24
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  23
gccccgcucg ucgcggucug ggcu                                              24


<210>  24
<211>  6
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  n is a, c, g, or t

<400>  24
nngrrt                                                                   6


<210>  25
<211>  6
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  n is a, c, g, or t

<400>  25
nngrrv                                                                   6


<210>  26
<211>  3159
<212>  DNA
<213>  Staphylococcus aureus

<400>  26
atgaaaagga actacattct ggggctggcc atcgggatta caagcgtggg gtatgggatt       60

attgactatg aaacaaggga cgtgatcgac gcaggcgtca gactgttcaa ggaggccaac      120

gtggaaaaca atgagggacg gagaagcaag aggggagcca ggcgcctgaa acgacggaga      180

aggcacagaa tccagagggt gaagaaactg ctgttcgatt acaacctgct gaccgaccat      240

tctgagctga gtggaattaa tccttatgaa gccagggtga aaggcctgag tcagaagctg      300

tcagaggaag agttttccgc agctctgctg cacctggcta agcgccgagg agtgcataac      360

gtcaatgagg tggaagagga caccggcaac gagctgtcta caaaggaaca gatctcacgc      420

aatagcaaag ctctggaaga gaagtatgtc gcagagctgc agctggaacg gctgaagaaa      480

gatggcgagg tgagagggtc aattaatagg ttcaagacaa gcgactacgt caaagaagcc      540

aagcagctgc tgaaagtgca gaaggcttac caccagctgg atcagagctt catcgatact      600

tatatcgacc tgctggagac tcggagaacc tactatgagg gaccaggaga agggagcccc      660

ttcggatgga aagacatcaa ggaatggtac gagatgctga tgggacattg cacctatttt      720

ccagaagagc tgagaagcgt caagtacgct tataacgcag atctgtacaa cgccctgaat      780

gacctgaaca acctggtcat caccagggat gaaaacgaga aactggaata ctatgagaag      840

ttccagatca tcgaaaacgt gtttaagcag aagaaaaagc ctacactgaa acagattgct      900

aaggagatcc tggtcaacga agaggacatc aagggctacc gggtgacaag cactggaaaa      960

ccagagttca ccaatctgaa agtgtatcac gatattaagg acatcacagc acggaaagaa     1020

atcattgaga acgccgaact gctggatcag attgctaaga tcctgactat ctaccagagc     1080

tccgaggaca tccaggaaga gctgactaac ctgaacagcg agctgaccca ggaagagatc     1140

gaacagatta gtaatctgaa ggggtacacc ggaacacaca acctgtccct gaaagctatc     1200

aatctgattc tggatgagct gtggcataca aacgacaatc agattgcaat ctttaaccgg     1260

ctgaagctgg tcccaaaaaa ggtggacctg agtcagcaga aagagatccc aaccacactg     1320

gtggacgatt tcattctgtc acccgtggtc aagcggagct tcatccagag catcaaagtg     1380

atcaacgcca tcatcaagaa gtacggcctg cccaatgata tcattatcga gctggctagg     1440

gagaagaaca gcaaggacgc acagaagatg atcaatgaga tgcagaaacg aaaccggcag     1500

accaatgaac gcattgaaga gattatccga actaccggga aagagaacgc aaagtacctg     1560

attgaaaaaa tcaagctgca cgatatgcag gagggaaagt gtctgtattc tctggaggcc     1620

atccccctgg aggacctgct gaacaatcca ttcaactacg aggtcgatca tattatcccc     1680

agaagcgtgt ccttcgacaa ttcctttaac aacaaggtgc tggtcaagca ggaagagaac     1740

tctaaaaagg gcaataggac tcctttccag tacctgtcta gttcagattc caagatctct     1800

tacgaaacct ttaaaaagca cattctgaat ctggccaaag gaaagggccg catcagcaag     1860

accaaaaagg agtacctgct ggaagagcgg gacatcaaca gattctccgt ccagaaggat     1920

tttattaacc ggaatctggt ggacacaaga tacgctactc gcggcctgat gaatctgctg     1980

cgatcctatt tccgggtgaa caatctggat gtgaaagtca agtccatcaa cggcgggttc     2040

acatcttttc tgaggcgcaa atggaagttt aaaaaggagc gcaacaaagg gtacaagcac     2100

catgccgaag atgctctgat tatcgcaaat gccgacttca tctttaagga gtggaaaaag     2160

ctggacaaag ccaagaaagt gatggagaac cagatgttcg aagagaagca ggccgaatct     2220

atgcccgaaa tcgagacaga acaggagtac aaggagattt tcatcactcc tcaccagatc     2280

aagcatatca aggatttcaa ggactacaag tactctcacc gggtggataa aaagcccaac     2340

agagagctga tcaatgacac cctgtatagt acaagaaaag acgataaggg gaataccctg     2400

attgtgaaca atctgaacgg actgtacgac aaagataatg acaagctgaa aaagctgatc     2460

aacaaaagtc ccgagaagct gctgatgtac caccatgatc ctcagacata tcagaaactg     2520

aagctgatta tggagcagta cggcgacgag aagaacccac tgtataagta ctatgaagag     2580

actgggaact acctgaccaa gtatagcaaa aaggataatg gccccgtgat caagaagatc     2640

aagtactatg ggaacaagct gaatgcccat ctggacatca cagacgatta ccctaacagt     2700

cgcaacaagg tggtcaagct gtcactgaag ccatacagat tcgatgtcta tctggacaac     2760

ggcgtgtata aatttgtgac tgtcaagaat ctggatgtca tcaaaaagga gaactactat     2820

gaagtgaata gcaagtgcta cgaagaggct aaaaagctga aaaagattag caaccaggca     2880

gagttcatcg cctcctttta caacaacgac ctgattaaga tcaatggcga actgtatagg     2940

gtcatcgggg tgaacaatga tctgctgaac cgcattgaag tgaatatgat tgacatcact     3000

taccgagagt atctggaaaa catgaatgat aagcgccccc ctcgaattat caaaacaatt     3060

gcctctaaga ctcagagtat caaaaagtac tcaaccgaca ttctgggaaa cctgtatgag     3120

gtgaagagca aaaagcaccc tcagattatc aaaaagggc                            3159


<210>  27
<211>  3159
<212>  DNA
<213>  Staphylococcus aureus

<400>  27
atgaaaagga actacattct ggggctggac atcgggatta caagcgtggg gtatgggatt       60

attgactatg aaacaaggga cgtgatcgac gcaggcgtca gactgttcaa ggaggccaac      120

gtggaaaaca atgagggacg gagaagcaag aggggagcca ggcgcctgaa acgacggaga      180

aggcacagaa tccagagggt gaagaaactg ctgttcgatt acaacctgct gaccgaccat      240

tctgagctga gtggaattaa tccttatgaa gccagggtga aaggcctgag tcagaagctg      300

tcagaggaag agttttccgc agctctgctg cacctggcta agcgccgagg agtgcataac      360

gtcaatgagg tggaagagga caccggcaac gagctgtcta caaaggaaca gatctcacgc      420

aatagcaaag ctctggaaga gaagtatgtc gcagagctgc agctggaacg gctgaagaaa      480

gatggcgagg tgagagggtc aattaatagg ttcaagacaa gcgactacgt caaagaagcc      540

aagcagctgc tgaaagtgca gaaggcttac caccagctgg atcagagctt catcgatact      600

tatatcgacc tgctggagac tcggagaacc tactatgagg gaccaggaga agggagcccc      660

ttcggatgga aagacatcaa ggaatggtac gagatgctga tgggacattg cacctatttt      720

ccagaagagc tgagaagcgt caagtacgct tataacgcag atctgtacaa cgccctgaat      780

gacctgaaca acctggtcat caccagggat gaaaacgaga aactggaata ctatgagaag      840

ttccagatca tcgaaaacgt gtttaagcag aagaaaaagc ctacactgaa acagattgct      900

aaggagatcc tggtcaacga agaggacatc aagggctacc gggtgacaag cactggaaaa      960

ccagagttca ccaatctgaa agtgtatcac gatattaagg acatcacagc acggaaagaa     1020

atcattgaga acgccgaact gctggatcag attgctaaga tcctgactat ctaccagagc     1080

tccgaggaca tccaggaaga gctgactaac ctgaacagcg agctgaccca ggaagagatc     1140

gaacagatta gtaatctgaa ggggtacacc ggaacacaca acctgtccct gaaagctatc     1200

aatctgattc tggatgagct gtggcataca aacgacaatc agattgcaat ctttaaccgg     1260

ctgaagctgg tcccaaaaaa ggtggacctg agtcagcaga aagagatccc aaccacactg     1320

gtggacgatt tcattctgtc acccgtggtc aagcggagct tcatccagag catcaaagtg     1380

atcaacgcca tcatcaagaa gtacggcctg cccaatgata tcattatcga gctggctagg     1440

gagaagaaca gcaaggacgc acagaagatg atcaatgaga tgcagaaacg aaaccggcag     1500

accaatgaac gcattgaaga gattatccga actaccggga aagagaacgc aaagtacctg     1560

attgaaaaaa tcaagctgca cgatatgcag gagggaaagt gtctgtattc tctggaggcc     1620

atccccctgg aggacctgct gaacaatcca ttcaactacg aggtcgatca tattatcccc     1680

agaagcgtgt ccttcgacaa ttcctttaac aacaaggtgc tggtcaagca ggaagaggcc     1740

tctaaaaagg gcaataggac tcctttccag tacctgtcta gttcagattc caagatctct     1800

tacgaaacct ttaaaaagca cattctgaat ctggccaaag gaaagggccg catcagcaag     1860

accaaaaagg agtacctgct ggaagagcgg gacatcaaca gattctccgt ccagaaggat     1920

tttattaacc ggaatctggt ggacacaaga tacgctactc gcggcctgat gaatctgctg     1980

cgatcctatt tccgggtgaa caatctggat gtgaaagtca agtccatcaa cggcgggttc     2040

acatcttttc tgaggcgcaa atggaagttt aaaaaggagc gcaacaaagg gtacaagcac     2100

catgccgaag atgctctgat tatcgcaaat gccgacttca tctttaagga gtggaaaaag     2160

ctggacaaag ccaagaaagt gatggagaac cagatgttcg aagagaagca ggccgaatct     2220

atgcccgaaa tcgagacaga acaggagtac aaggagattt tcatcactcc tcaccagatc     2280

aagcatatca aggatttcaa ggactacaag tactctcacc gggtggataa aaagcccaac     2340

agagagctga tcaatgacac cctgtatagt acaagaaaag acgataaggg gaataccctg     2400

attgtgaaca atctgaacgg actgtacgac aaagataatg acaagctgaa aaagctgatc     2460

aacaaaagtc ccgagaagct gctgatgtac caccatgatc ctcagacata tcagaaactg     2520

aagctgatta tggagcagta cggcgacgag aagaacccac tgtataagta ctatgaagag     2580

actgggaact acctgaccaa gtatagcaaa aaggataatg gccccgtgat caagaagatc     2640

aagtactatg ggaacaagct gaatgcccat ctggacatca cagacgatta ccctaacagt     2700

cgcaacaagg tggtcaagct gtcactgaag ccatacagat tcgatgtcta tctggacaac     2760

ggcgtgtata aatttgtgac tgtcaagaat ctggatgtca tcaaaaagga gaactactat     2820

gaagtgaata gcaagtgcta cgaagaggct aaaaagctga aaaagattag caaccaggca     2880

gagttcatcg cctcctttta caacaacgac ctgattaaga tcaatggcga actgtatagg     2940

gtcatcgggg tgaacaatga tctgctgaac cgcattgaag tgaatatgat tgacatcact     3000

taccgagagt atctggaaaa catgaatgat aagcgccccc ctcgaattat caaaacaatt     3060

gcctctaaga ctcagagtat caaaaagtac tcaaccgaca ttctgggaaa cctgtatgag     3120

gtgaagagca aaaagcaccc tcagattatc aaaaagggc                            3159


<210>  28
<211>  4107
<212>  DNA
<213>  Streptococcus pyogenes

<400>  28
atggataaaa agtacagcat cgggctggac atcggtacaa actcagtggg gtgggccgtg       60

attacggacg agtacaaggt accctccaaa aaatttaaag tgctgggtaa cacggacaga      120

cactctataa agaaaaatct tattggagcc ttgctgttcg actcaggcga gacagccgaa      180

gccacaaggt tgaagcggac cgccaggagg cggtatacca ggagaaagaa ccgcatatgc      240

tacctgcaag aaatcttcag taacgagatg gcaaaggttg acgatagctt tttccatcgc      300

ctggaagaat cctttcttgt tgaggaagac aagaagcacg aacggcaccc catctttggc      360

aatattgtcg acgaagtggc atatcacgaa aagtacccga ctatctacca cctcaggaag      420

aagctggtgg actctaccga taaggcggac ctcagactta tttatttggc actcgcccac      480

atgattaaat ttagaggaca tttcttgatc gagggcgacc tgaacccgga caacagtgac      540

gtcgataagc tgttcatcca acttgtgcag acctacaatc aactgttcga agaaaaccct      600

ataaatgctt caggagtcga cgctaaagca atcctgtccg cgcgcctctc aaaatctaga      660

agacttgaga atctgattgc tcagttgccc ggggaaaaga aaaatggatt gtttggcaac      720

ctgatcgccc tcagtctcgg actgacccca aatttcaaaa gtaacttcga cctggccgaa      780

gacgctaagc tccagctgtc caaggacaca tacgatgacg acctcgacaa tctgctggcc      840

cagattgggg atcagtacgc cgatctcttt ttggcagcaa agaacctgtc cgacgccatc      900

ctgttgagcg atatcttgag agtgaacacc gaaattacta aagcacccct tagcgcatct      960

atgatcaagc ggtacgacga gcatcatcag gatctgaccc tgctgaaggc tcttgtgagg     1020

caacagctcc ccgaaaaata caaggaaatc ttctttgacc agagcaaaaa cggctacgct     1080

ggctatatag atggtggggc cagtcaggag gaattctata aattcatcaa gcccattctc     1140

gagaaaatgg acggcacaga ggagttgctg gtcaaactta acagggagga cctgctgcgg     1200

aagcagcgga cctttgacaa cgggtctatc ccccaccaga ttcatctggg cgaactgcac     1260

gcaatcctga ggaggcagga ggatttttat ccttttctta aagataaccg cgagaaaata     1320

gaaaagattc ttacattcag gatcccgtac tacgtgggac ctctcgcccg gggcaattca     1380

cggtttgcct ggatgacaag gaagtcagag gagactatta caccttggaa cttcgaagaa     1440

gtggtggaca agggtgcatc tgcccagtct ttcatcgagc ggatgacaaa ttttgacaag     1500

aacctcccta atgagaaggt gctgcccaaa cattctctgc tctacgagta ctttaccgtc     1560

tacaatgaac tgactaaagt caagtacgtc accgagggaa tgaggaagcc ggcattcctt     1620

agtggagaac agaagaaggc gattgtagac ctgttgttca agaccaacag gaaggtgact     1680

gtgaagcaac ttaaagaaga ctactttaag aagatcgaat gttttgacag tgtggaaatt     1740

tcaggggttg aagaccgctt caatgcgtca ttggggactt accatgatct tctcaagatc     1800

ataaaggaca aagacttcct ggacaacgaa gaaaatgagg atattctcga agacatcgtc     1860

ctcaccctga ccctgttcga agacagggaa atgatagaag agcgcttgaa aacctatgcc     1920

cacctcttcg acgataaagt tatgaagcag ctgaagcgca ggagatacac aggatgggga     1980

agattgtcaa ggaagctgat caatggaatt agggataaac agagtggcaa gaccatactg     2040

gatttcctca aatctgatgg cttcgccaat aggaacttca tgcaactgat tcacgatgac     2100

tctcttacct tcaaggagga cattcaaaag gctcaggtga gcgggcaggg agactccctt     2160

catgaacaca tcgcgaattt ggcaggttcc cccgctatta aaaagggcat ccttcaaact     2220

gtcaaggtgg tggatgaatt ggtcaaggta atgggcagac ataagccaga aaatattgtg     2280

atcgagatgg cccgcgaaaa ccagaccaca cagaagggcc agaaaaatag tagagagcgg     2340

atgaagagga tcgaggaggg catcaaagag ctgggatctc agattctcaa agaacacccc     2400

gtagaaaaca cacagctgca gaacgaaaaa ttgtacttgt actatctgca gaacggcaga     2460

gacatgtacg tcgaccaaga acttgatatt aatagactgt ccgactatga cgtagaccat     2520

atcgtgcccc agtccttcct gaaggacgac tccattgata acaaagtctt gacaagaagc     2580

gacaagaaca ggggtaaaag tgataatgtg cctagcgagg aggtggtgaa aaaaatgaag     2640

aactactggc gacagctgct taatgcaaag ctcattacac aacggaagtt cgataatctg     2700

acgaaagcag agagaggtgg cttgtctgag ttggacaagg cagggtttat taagcggcag     2760

ctggtggaaa ctaggcagat cacaaagcac gtggcgcaga ttttggacag ccggatgaac     2820

acaaaatacg acgaaaatga taaactgata cgagaggtca aagttatcac gctgaaaagc     2880

aagctggtgt ccgattttcg gaaagacttc cagttctaca aagttcgcga gattaataac     2940

taccatcatg ctcacgatgc gtacctgaac gctgttgtcg ggaccgcctt gataaagaag     3000

tacccaaagc tggaatccga gttcgtatac ggggattaca aagtgtacga tgtgaggaaa     3060

atgatagcca agtccgagca ggagattgga aaggccacag ctaagtactt cttttattct     3120

aacatcatga atttttttaa gacggaaatt accctggcca acggagagat cagaaagcgg     3180

ccccttatag agacaaatgg tgaaacaggt gaaatcgtct gggataaggg cagggatttc     3240

gctactgtga ggaaggtgct gagtatgcca caggtaaata tcgtgaaaaa aaccgaagta     3300

cagaccggag gattttccaa ggaaagcatt ttgcctaaaa gaaactcaga caagctcatc     3360

gcccgcaaga aagattggga ccctaagaaa tacgggggat ttgactcacc caccgtagcc     3420

tattctgtgc tggtggtagc taaggtggaa aaaggaaagt ctaagaagct gaagtccgtg     3480

aaggaactct tgggaatcac tatcatggaa agatcatcct ttgaaaagaa ccctatcgat     3540

ttcctggagg ctaagggtta caaggaggtc aagaaagacc tcatcattaa actgccaaaa     3600

tactctctct tcgagctgga aaatggcagg aagagaatgt tggccagcgc cggagagctg     3660

caaaagggaa acgagcttgc tctgccctcc aaatatgtta attttctcta tctcgcttcc     3720

cactatgaaa agctgaaagg gtctcccgaa gataacgagc agaagcagct gttcgtcgaa     3780

cagcacaagc actatctgga tgaaataatc gaacaaataa gcgagttcag caaaagggtt     3840

atcctggcgg atgctaattt ggacaaagta ctgtctgctt ataacaagca ccgggataag     3900

cctattaggg aacaagccga gaatataatt cacctcttta cactcacgaa tctcggagcc     3960

cccgccgcct tcaaatactt tgatacgact atcgaccgga aacggtatac cagtaccaaa     4020

gaggtcctcg atgccaccct catccaccag tcaattactg gcctgtacga aacacggatc     4080

gacctctctc aactgggcgg cgactag                                         4107


<210>  29
<211>  1368
<212>  PRT
<213>  Streptococcus pyogenes


<220>
<221>  misc_feature
<222>  (10)..(21)
<223>  N-terminal RuvC-like domain

<220>
<221>  misc_feature
<222>  (759)..(766)
<223>  RuvC-like domain

<220>
<221>  misc_feature
<222>  (837)..(863)
<223>  HNH-like domain

<220>
<221>  misc_feature
<222>  (982)..(989)
<223>  RuvC-like domain

<400>  29

Met Asp Lys Lys Tyr Ser Ile Gly Leu Asp Ile Gly Thr Asn Ser Val 
1               5                   10                  15      


Gly Trp Ala Val Ile Thr Asp Glu Tyr Lys Val Pro Ser Lys Lys Phe 
            20                  25                  30          


Lys Val Leu Gly Asn Thr Asp Arg His Ser Ile Lys Lys Asn Leu Ile 
        35                  40                  45              


Gly Ala Leu Leu Phe Asp Ser Gly Glu Thr Ala Glu Ala Thr Arg Leu 
    50                  55                  60                  


Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Lys Asn Arg Ile Cys 
65                  70                  75                  80  


Tyr Leu Gln Glu Ile Phe Ser Asn Glu Met Ala Lys Val Asp Asp Ser 
                85                  90                  95      


Phe Phe His Arg Leu Glu Glu Ser Phe Leu Val Glu Glu Asp Lys Lys 
            100                 105                 110         


His Glu Arg His Pro Ile Phe Gly Asn Ile Val Asp Glu Val Ala Tyr 
        115                 120                 125             


His Glu Lys Tyr Pro Thr Ile Tyr His Leu Arg Lys Lys Leu Val Asp 
    130                 135                 140                 


Ser Thr Asp Lys Ala Asp Leu Arg Leu Ile Tyr Leu Ala Leu Ala His 
145                 150                 155                 160 


Met Ile Lys Phe Arg Gly His Phe Leu Ile Glu Gly Asp Leu Asn Pro 
                165                 170                 175     


Asp Asn Ser Asp Val Asp Lys Leu Phe Ile Gln Leu Val Gln Thr Tyr 
            180                 185                 190         


Asn Gln Leu Phe Glu Glu Asn Pro Ile Asn Ala Ser Gly Val Asp Ala 
        195                 200                 205             


Lys Ala Ile Leu Ser Ala Arg Leu Ser Lys Ser Arg Arg Leu Glu Asn 
    210                 215                 220                 


Leu Ile Ala Gln Leu Pro Gly Glu Lys Lys Asn Gly Leu Phe Gly Asn 
225                 230                 235                 240 


Leu Ile Ala Leu Ser Leu Gly Leu Thr Pro Asn Phe Lys Ser Asn Phe 
                245                 250                 255     


Asp Leu Ala Glu Asp Ala Lys Leu Gln Leu Ser Lys Asp Thr Tyr Asp 
            260                 265                 270         


Asp Asp Leu Asp Asn Leu Leu Ala Gln Ile Gly Asp Gln Tyr Ala Asp 
        275                 280                 285             


Leu Phe Leu Ala Ala Lys Asn Leu Ser Asp Ala Ile Leu Leu Ser Asp 
    290                 295                 300                 


Ile Leu Arg Val Asn Thr Glu Ile Thr Lys Ala Pro Leu Ser Ala Ser 
305                 310                 315                 320 


Met Ile Lys Arg Tyr Asp Glu His His Gln Asp Leu Thr Leu Leu Lys 
                325                 330                 335     


Ala Leu Val Arg Gln Gln Leu Pro Glu Lys Tyr Lys Glu Ile Phe Phe 
            340                 345                 350         


Asp Gln Ser Lys Asn Gly Tyr Ala Gly Tyr Ile Asp Gly Gly Ala Ser 
        355                 360                 365             


Gln Glu Glu Phe Tyr Lys Phe Ile Lys Pro Ile Leu Glu Lys Met Asp 
    370                 375                 380                 


Gly Thr Glu Glu Leu Leu Val Lys Leu Asn Arg Glu Asp Leu Leu Arg 
385                 390                 395                 400 


Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln Ile His Leu 
                405                 410                 415     


Gly Glu Leu His Ala Ile Leu Arg Arg Gln Glu Asp Phe Tyr Pro Phe 
            420                 425                 430         


Leu Lys Asp Asn Arg Glu Lys Ile Glu Lys Ile Leu Thr Phe Arg Ile 
        435                 440                 445             


Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly Asn Ser Arg Phe Ala Trp 
    450                 455                 460                 


Met Thr Arg Lys Ser Glu Glu Thr Ile Thr Pro Trp Asn Phe Glu Glu 
465                 470                 475                 480 


Val Val Asp Lys Gly Ala Ser Ala Gln Ser Phe Ile Glu Arg Met Thr 
                485                 490                 495     


Asn Phe Asp Lys Asn Leu Pro Asn Glu Lys Val Leu Pro Lys His Ser 
            500                 505                 510         


Leu Leu Tyr Glu Tyr Phe Thr Val Tyr Asn Glu Leu Thr Lys Val Lys 
        515                 520                 525             


Tyr Val Thr Glu Gly Met Arg Lys Pro Ala Phe Leu Ser Gly Glu Gln 
    530                 535                 540                 


Lys Lys Ala Ile Val Asp Leu Leu Phe Lys Thr Asn Arg Lys Val Thr 
545                 550                 555                 560 


Val Lys Gln Leu Lys Glu Asp Tyr Phe Lys Lys Ile Glu Cys Phe Asp 
                565                 570                 575     


Ser Val Glu Ile Ser Gly Val Glu Asp Arg Phe Asn Ala Ser Leu Gly 
            580                 585                 590         


Thr Tyr His Asp Leu Leu Lys Ile Ile Lys Asp Lys Asp Phe Leu Asp 
        595                 600                 605             


Asn Glu Glu Asn Glu Asp Ile Leu Glu Asp Ile Val Leu Thr Leu Thr 
    610                 615                 620                 


Leu Phe Glu Asp Arg Glu Met Ile Glu Glu Arg Leu Lys Thr Tyr Ala 
625                 630                 635                 640 


His Leu Phe Asp Asp Lys Val Met Lys Gln Leu Lys Arg Arg Arg Tyr 
                645                 650                 655     


Thr Gly Trp Gly Arg Leu Ser Arg Lys Leu Ile Asn Gly Ile Arg Asp 
            660                 665                 670         


Lys Gln Ser Gly Lys Thr Ile Leu Asp Phe Leu Lys Ser Asp Gly Phe 
        675                 680                 685             


Ala Asn Arg Asn Phe Met Gln Leu Ile His Asp Asp Ser Leu Thr Phe 
    690                 695                 700                 


Lys Glu Asp Ile Gln Lys Ala Gln Val Ser Gly Gln Gly Asp Ser Leu 
705                 710                 715                 720 


His Glu His Ile Ala Asn Leu Ala Gly Ser Pro Ala Ile Lys Lys Gly 
                725                 730                 735     


Ile Leu Gln Thr Val Lys Val Val Asp Glu Leu Val Lys Val Met Gly 
            740                 745                 750         


Arg His Lys Pro Glu Asn Ile Val Ile Glu Met Ala Arg Glu Asn Gln 
        755                 760                 765             


Thr Thr Gln Lys Gly Gln Lys Asn Ser Arg Glu Arg Met Lys Arg Ile 
    770                 775                 780                 


Glu Glu Gly Ile Lys Glu Leu Gly Ser Gln Ile Leu Lys Glu His Pro 
785                 790                 795                 800 


Val Glu Asn Thr Gln Leu Gln Asn Glu Lys Leu Tyr Leu Tyr Tyr Leu 
                805                 810                 815     


Gln Asn Gly Arg Asp Met Tyr Val Asp Gln Glu Leu Asp Ile Asn Arg 
            820                 825                 830         


Leu Ser Asp Tyr Asp Val Asp His Ile Val Pro Gln Ser Phe Leu Lys 
        835                 840                 845             


Asp Asp Ser Ile Asp Asn Lys Val Leu Thr Arg Ser Asp Lys Asn Arg 
    850                 855                 860                 


Gly Lys Ser Asp Asn Val Pro Ser Glu Glu Val Val Lys Lys Met Lys 
865                 870                 875                 880 


Asn Tyr Trp Arg Gln Leu Leu Asn Ala Lys Leu Ile Thr Gln Arg Lys 
                885                 890                 895     


Phe Asp Asn Leu Thr Lys Ala Glu Arg Gly Gly Leu Ser Glu Leu Asp 
            900                 905                 910         


Lys Ala Gly Phe Ile Lys Arg Gln Leu Val Glu Thr Arg Gln Ile Thr 
        915                 920                 925             


Lys His Val Ala Gln Ile Leu Asp Ser Arg Met Asn Thr Lys Tyr Asp 
    930                 935                 940                 


Glu Asn Asp Lys Leu Ile Arg Glu Val Lys Val Ile Thr Leu Lys Ser 
945                 950                 955                 960 


Lys Leu Val Ser Asp Phe Arg Lys Asp Phe Gln Phe Tyr Lys Val Arg 
                965                 970                 975     


Glu Ile Asn Asn Tyr His His Ala His Asp Ala Tyr Leu Asn Ala Val 
            980                 985                 990         


Val Gly Thr Ala Leu Ile Lys Lys  Tyr Pro Lys Leu Glu  Ser Glu Phe 
        995                 1000                 1005             


Val Tyr  Gly Asp Tyr Lys Val  Tyr Asp Val Arg Lys  Met Ile Ala 
    1010                 1015                 1020             


Lys Ser  Glu Gln Glu Ile Gly  Lys Ala Thr Ala Lys  Tyr Phe Phe 
    1025                 1030                 1035             


Tyr Ser  Asn Ile Met Asn Phe  Phe Lys Thr Glu Ile  Thr Leu Ala 
    1040                 1045                 1050             


Asn Gly  Glu Ile Arg Lys Arg  Pro Leu Ile Glu Thr  Asn Gly Glu 
    1055                 1060                 1065             


Thr Gly  Glu Ile Val Trp Asp  Lys Gly Arg Asp Phe  Ala Thr Val 
    1070                 1075                 1080             


Arg Lys  Val Leu Ser Met Pro  Gln Val Asn Ile Val  Lys Lys Thr 
    1085                 1090                 1095             


Glu Val  Gln Thr Gly Gly Phe  Ser Lys Glu Ser Ile  Leu Pro Lys 
    1100                 1105                 1110             


Arg Asn  Ser Asp Lys Leu Ile  Ala Arg Lys Lys Asp  Trp Asp Pro 
    1115                 1120                 1125             


Lys Lys  Tyr Gly Gly Phe Asp  Ser Pro Thr Val Ala  Tyr Ser Val 
    1130                 1135                 1140             


Leu Val  Val Ala Lys Val Glu  Lys Gly Lys Ser Lys  Lys Leu Lys 
    1145                 1150                 1155             


Ser Val  Lys Glu Leu Leu Gly  Ile Thr Ile Met Glu  Arg Ser Ser 
    1160                 1165                 1170             


Phe Glu  Lys Asn Pro Ile Asp  Phe Leu Glu Ala Lys  Gly Tyr Lys 
    1175                 1180                 1185             


Glu Val  Lys Lys Asp Leu Ile  Ile Lys Leu Pro Lys  Tyr Ser Leu 
    1190                 1195                 1200             


Phe Glu  Leu Glu Asn Gly Arg  Lys Arg Met Leu Ala  Ser Ala Gly 
    1205                 1210                 1215             


Glu Leu  Gln Lys Gly Asn Glu  Leu Ala Leu Pro Ser  Lys Tyr Val 
    1220                 1225                 1230             


Asn Phe  Leu Tyr Leu Ala Ser  His Tyr Glu Lys Leu  Lys Gly Ser 
    1235                 1240                 1245             


Pro Glu  Asp Asn Glu Gln Lys  Gln Leu Phe Val Glu  Gln His Lys 
    1250                 1255                 1260             


His Tyr  Leu Asp Glu Ile Ile  Glu Gln Ile Ser Glu  Phe Ser Lys 
    1265                 1270                 1275             


Arg Val  Ile Leu Ala Asp Ala  Asn Leu Asp Lys Val  Leu Ser Ala 
    1280                 1285                 1290             


Tyr Asn  Lys His Arg Asp Lys  Pro Ile Arg Glu Gln  Ala Glu Asn 
    1295                 1300                 1305             


Ile Ile  His Leu Phe Thr Leu  Thr Asn Leu Gly Ala  Pro Ala Ala 
    1310                 1315                 1320             


Phe Lys  Tyr Phe Asp Thr Thr  Ile Asp Arg Lys Arg  Tyr Thr Ser 
    1325                 1330                 1335             


Thr Lys  Glu Val Leu Asp Ala  Thr Leu Ile His Gln  Ser Ile Thr 
    1340                 1345                 1350             


Gly Leu  Tyr Glu Thr Arg Ile  Asp Leu Ser Gln Leu  Gly Gly Asp 
    1355                 1360                 1365             


<210>  30
<211>  1368
<212>  PRT
<213>  Streptococcus pyogenes


<220>
<221>  misc_feature
<223>  S. pyogenes Cas9 variant: EQR variant

<400>  30

Met Asp Lys Lys Tyr Ser Ile Gly Leu Asp Ile Gly Thr Asn Ser Val 
1               5                   10                  15      


Gly Trp Ala Val Ile Thr Asp Glu Tyr Lys Val Pro Ser Lys Lys Phe 
            20                  25                  30          


Lys Val Leu Gly Asn Thr Asp Arg His Ser Ile Lys Lys Asn Leu Ile 
        35                  40                  45              


Gly Ala Leu Leu Phe Asp Ser Gly Glu Thr Ala Glu Ala Thr Arg Leu 
    50                  55                  60                  


Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Lys Asn Arg Ile Cys 
65                  70                  75                  80  


Tyr Leu Gln Glu Ile Phe Ser Asn Glu Met Ala Lys Val Asp Asp Ser 
                85                  90                  95      


Phe Phe His Arg Leu Glu Glu Ser Phe Leu Val Glu Glu Asp Lys Lys 
            100                 105                 110         


His Glu Arg His Pro Ile Phe Gly Asn Ile Val Asp Glu Val Ala Tyr 
        115                 120                 125             


His Glu Lys Tyr Pro Thr Ile Tyr His Leu Arg Lys Lys Leu Val Asp 
    130                 135                 140                 


Ser Thr Asp Lys Ala Asp Leu Arg Leu Ile Tyr Leu Ala Leu Ala His 
145                 150                 155                 160 


Met Ile Lys Phe Arg Gly His Phe Leu Ile Glu Gly Asp Leu Asn Pro 
                165                 170                 175     


Asp Asn Ser Asp Val Asp Lys Leu Phe Ile Gln Leu Val Gln Thr Tyr 
            180                 185                 190         


Asn Gln Leu Phe Glu Glu Asn Pro Ile Asn Ala Ser Gly Val Asp Ala 
        195                 200                 205             


Lys Ala Ile Leu Ser Ala Arg Leu Ser Lys Ser Arg Arg Leu Glu Asn 
    210                 215                 220                 


Leu Ile Ala Gln Leu Pro Gly Glu Lys Lys Asn Gly Leu Phe Gly Asn 
225                 230                 235                 240 


Leu Ile Ala Leu Ser Leu Gly Leu Thr Pro Asn Phe Lys Ser Asn Phe 
                245                 250                 255     


Asp Leu Ala Glu Asp Ala Lys Leu Gln Leu Ser Lys Asp Thr Tyr Asp 
            260                 265                 270         


Asp Asp Leu Asp Asn Leu Leu Ala Gln Ile Gly Asp Gln Tyr Ala Asp 
        275                 280                 285             


Leu Phe Leu Ala Ala Lys Asn Leu Ser Asp Ala Ile Leu Leu Ser Asp 
    290                 295                 300                 


Ile Leu Arg Val Asn Thr Glu Ile Thr Lys Ala Pro Leu Ser Ala Ser 
305                 310                 315                 320 


Met Ile Lys Arg Tyr Asp Glu His His Gln Asp Leu Thr Leu Leu Lys 
                325                 330                 335     


Ala Leu Val Arg Gln Gln Leu Pro Glu Lys Tyr Lys Glu Ile Phe Phe 
            340                 345                 350         


Asp Gln Ser Lys Asn Gly Tyr Ala Gly Tyr Ile Asp Gly Gly Ala Ser 
        355                 360                 365             


Gln Glu Glu Phe Tyr Lys Phe Ile Lys Pro Ile Leu Glu Lys Met Asp 
    370                 375                 380                 


Gly Thr Glu Glu Leu Leu Val Lys Leu Asn Arg Glu Asp Leu Leu Arg 
385                 390                 395                 400 


Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln Ile His Leu 
                405                 410                 415     


Gly Glu Leu His Ala Ile Leu Arg Arg Gln Glu Asp Phe Tyr Pro Phe 
            420                 425                 430         


Leu Lys Asp Asn Arg Glu Lys Ile Glu Lys Ile Leu Thr Phe Arg Ile 
        435                 440                 445             


Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly Asn Ser Arg Phe Ala Trp 
    450                 455                 460                 


Met Thr Arg Lys Ser Glu Glu Thr Ile Thr Pro Trp Asn Phe Glu Glu 
465                 470                 475                 480 


Val Val Asp Lys Gly Ala Ser Ala Gln Ser Phe Ile Glu Arg Met Thr 
                485                 490                 495     


Asn Phe Asp Lys Asn Leu Pro Asn Glu Lys Val Leu Pro Lys His Ser 
            500                 505                 510         


Leu Leu Tyr Glu Tyr Phe Thr Val Tyr Asn Glu Leu Thr Lys Val Lys 
        515                 520                 525             


Tyr Val Thr Glu Gly Met Arg Lys Pro Ala Phe Leu Ser Gly Glu Gln 
    530                 535                 540                 


Lys Lys Ala Ile Val Asp Leu Leu Phe Lys Thr Asn Arg Lys Val Thr 
545                 550                 555                 560 


Val Lys Gln Leu Lys Glu Asp Tyr Phe Lys Lys Ile Glu Cys Phe Asp 
                565                 570                 575     


Ser Val Glu Ile Ser Gly Val Glu Asp Arg Phe Asn Ala Ser Leu Gly 
            580                 585                 590         


Thr Tyr His Asp Leu Leu Lys Ile Ile Lys Asp Lys Asp Phe Leu Asp 
        595                 600                 605             


Asn Glu Glu Asn Glu Asp Ile Leu Glu Asp Ile Val Leu Thr Leu Thr 
    610                 615                 620                 


Leu Phe Glu Asp Arg Glu Met Ile Glu Glu Arg Leu Lys Thr Tyr Ala 
625                 630                 635                 640 


His Leu Phe Asp Asp Lys Val Met Lys Gln Leu Lys Arg Arg Arg Tyr 
                645                 650                 655     


Thr Gly Trp Gly Arg Leu Ser Arg Lys Leu Ile Asn Gly Ile Arg Asp 
            660                 665                 670         


Lys Gln Ser Gly Lys Thr Ile Leu Asp Phe Leu Lys Ser Asp Gly Phe 
        675                 680                 685             


Ala Asn Arg Asn Phe Met Gln Leu Ile His Asp Asp Ser Leu Thr Phe 
    690                 695                 700                 


Lys Glu Asp Ile Gln Lys Ala Gln Val Ser Gly Gln Gly Asp Ser Leu 
705                 710                 715                 720 


His Glu His Ile Ala Asn Leu Ala Gly Ser Pro Ala Ile Lys Lys Gly 
                725                 730                 735     


Ile Leu Gln Thr Val Lys Val Val Asp Glu Leu Val Lys Val Met Gly 
            740                 745                 750         


Arg His Lys Pro Glu Asn Ile Val Ile Glu Met Ala Arg Glu Asn Gln 
        755                 760                 765             


Thr Thr Gln Lys Gly Gln Lys Asn Ser Arg Glu Arg Met Lys Arg Ile 
    770                 775                 780                 


Glu Glu Gly Ile Lys Glu Leu Gly Ser Gln Ile Leu Lys Glu His Pro 
785                 790                 795                 800 


Val Glu Asn Thr Gln Leu Gln Asn Glu Lys Leu Tyr Leu Tyr Tyr Leu 
                805                 810                 815     


Gln Asn Gly Arg Asp Met Tyr Val Asp Gln Glu Leu Asp Ile Asn Arg 
            820                 825                 830         


Leu Ser Asp Tyr Asp Val Asp His Ile Val Pro Gln Ser Phe Leu Lys 
        835                 840                 845             


Asp Asp Ser Ile Asp Asn Lys Val Leu Thr Arg Ser Asp Lys Asn Arg 
    850                 855                 860                 


Gly Lys Ser Asp Asn Val Pro Ser Glu Glu Val Val Lys Lys Met Lys 
865                 870                 875                 880 


Asn Tyr Trp Arg Gln Leu Leu Asn Ala Lys Leu Ile Thr Gln Arg Lys 
                885                 890                 895     


Phe Asp Asn Leu Thr Lys Ala Glu Arg Gly Gly Leu Ser Glu Leu Asp 
            900                 905                 910         


Lys Ala Gly Phe Ile Lys Arg Gln Leu Val Glu Thr Arg Gln Ile Thr 
        915                 920                 925             


Lys His Val Ala Gln Ile Leu Asp Ser Arg Met Asn Thr Lys Tyr Asp 
    930                 935                 940                 


Glu Asn Asp Lys Leu Ile Arg Glu Val Lys Val Ile Thr Leu Lys Ser 
945                 950                 955                 960 


Lys Leu Val Ser Asp Phe Arg Lys Asp Phe Gln Phe Tyr Lys Val Arg 
                965                 970                 975     


Glu Ile Asn Asn Tyr His His Ala His Asp Ala Tyr Leu Asn Ala Val 
            980                 985                 990         


Val Gly Thr Ala Leu Ile Lys Lys  Tyr Pro Lys Leu Glu  Ser Glu Phe 
        995                 1000                 1005             


Val Tyr  Gly Asp Tyr Lys Val  Tyr Asp Val Arg Lys  Met Ile Ala 
    1010                 1015                 1020             


Lys Ser  Glu Gln Glu Ile Gly  Lys Ala Thr Ala Lys  Tyr Phe Phe 
    1025                 1030                 1035             


Tyr Ser  Asn Ile Met Asn Phe  Phe Lys Thr Glu Ile  Thr Leu Ala 
    1040                 1045                 1050             


Asn Gly  Glu Ile Arg Lys Arg  Pro Leu Ile Glu Thr  Asn Gly Glu 
    1055                 1060                 1065             


Thr Gly  Glu Ile Val Trp Asp  Lys Gly Arg Asp Phe  Ala Thr Val 
    1070                 1075                 1080             


Arg Lys  Val Leu Ser Met Pro  Gln Val Asn Ile Val  Lys Lys Thr 
    1085                 1090                 1095             


Glu Val  Gln Thr Gly Gly Phe  Ser Lys Glu Ser Ile  Leu Pro Lys 
    1100                 1105                 1110             


Arg Asn  Ser Asp Lys Leu Ile  Ala Arg Lys Lys Asp  Trp Asp Pro 
    1115                 1120                 1125             


Lys Lys  Tyr Gly Gly Phe Glu  Ser Pro Thr Val Ala  Tyr Ser Val 
    1130                 1135                 1140             


Leu Val  Val Ala Lys Val Glu  Lys Gly Lys Ser Lys  Lys Leu Lys 
    1145                 1150                 1155             


Ser Val  Lys Glu Leu Leu Gly  Ile Thr Ile Met Glu  Arg Ser Ser 
    1160                 1165                 1170             


Phe Glu  Lys Asn Pro Ile Asp  Phe Leu Glu Ala Lys  Gly Tyr Lys 
    1175                 1180                 1185             


Glu Val  Lys Lys Asp Leu Ile  Ile Lys Leu Pro Lys  Tyr Ser Leu 
    1190                 1195                 1200             


Phe Glu  Leu Glu Asn Gly Arg  Lys Arg Met Leu Ala  Ser Ala Gly 
    1205                 1210                 1215             


Glu Leu  Gln Lys Gly Asn Glu  Leu Ala Leu Pro Ser  Lys Tyr Val 
    1220                 1225                 1230             


Asn Phe  Leu Tyr Leu Ala Ser  His Tyr Glu Lys Leu  Lys Gly Ser 
    1235                 1240                 1245             


Pro Glu  Asp Asn Glu Gln Lys  Gln Leu Phe Val Glu  Gln His Lys 
    1250                 1255                 1260             


His Tyr  Leu Asp Glu Ile Ile  Glu Gln Ile Ser Glu  Phe Ser Lys 
    1265                 1270                 1275             


Arg Val  Ile Leu Ala Asp Ala  Asn Leu Asp Lys Val  Leu Ser Ala 
    1280                 1285                 1290             


Tyr Asn  Lys His Arg Asp Lys  Pro Ile Arg Glu Gln  Ala Glu Asn 
    1295                 1300                 1305             


Ile Ile  His Leu Phe Thr Leu  Thr Asn Leu Gly Ala  Pro Ala Ala 
    1310                 1315                 1320             


Phe Lys  Tyr Phe Asp Thr Thr  Ile Asp Arg Lys Gln  Tyr Arg Ser 
    1325                 1330                 1335             


Thr Lys  Glu Val Leu Asp Ala  Thr Leu Ile His Gln  Ser Ile Thr 
    1340                 1345                 1350             


Gly Leu  Tyr Glu Thr Arg Ile  Asp Leu Ser Gln Leu  Gly Gly Asp 
    1355                 1360                 1365             


<210>  31
<211>  1368
<212>  PRT
<213>  Streptococcus pyogenes


<220>
<221>  misc_feature
<223>  S. pyogenes Cas9 variant: VRER variant

<400>  31

Met Asp Lys Lys Tyr Ser Ile Gly Leu Asp Ile Gly Thr Asn Ser Val 
1               5                   10                  15      


Gly Trp Ala Val Ile Thr Asp Glu Tyr Lys Val Pro Ser Lys Lys Phe 
            20                  25                  30          


Lys Val Leu Gly Asn Thr Asp Arg His Ser Ile Lys Lys Asn Leu Ile 
        35                  40                  45              


Gly Ala Leu Leu Phe Asp Ser Gly Glu Thr Ala Glu Ala Thr Arg Leu 
    50                  55                  60                  


Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Lys Asn Arg Ile Cys 
65                  70                  75                  80  


Tyr Leu Gln Glu Ile Phe Ser Asn Glu Met Ala Lys Val Asp Asp Ser 
                85                  90                  95      


Phe Phe His Arg Leu Glu Glu Ser Phe Leu Val Glu Glu Asp Lys Lys 
            100                 105                 110         


His Glu Arg His Pro Ile Phe Gly Asn Ile Val Asp Glu Val Ala Tyr 
        115                 120                 125             


His Glu Lys Tyr Pro Thr Ile Tyr His Leu Arg Lys Lys Leu Val Asp 
    130                 135                 140                 


Ser Thr Asp Lys Ala Asp Leu Arg Leu Ile Tyr Leu Ala Leu Ala His 
145                 150                 155                 160 


Met Ile Lys Phe Arg Gly His Phe Leu Ile Glu Gly Asp Leu Asn Pro 
                165                 170                 175     


Asp Asn Ser Asp Val Asp Lys Leu Phe Ile Gln Leu Val Gln Thr Tyr 
            180                 185                 190         


Asn Gln Leu Phe Glu Glu Asn Pro Ile Asn Ala Ser Gly Val Asp Ala 
        195                 200                 205             


Lys Ala Ile Leu Ser Ala Arg Leu Ser Lys Ser Arg Arg Leu Glu Asn 
    210                 215                 220                 


Leu Ile Ala Gln Leu Pro Gly Glu Lys Lys Asn Gly Leu Phe Gly Asn 
225                 230                 235                 240 


Leu Ile Ala Leu Ser Leu Gly Leu Thr Pro Asn Phe Lys Ser Asn Phe 
                245                 250                 255     


Asp Leu Ala Glu Asp Ala Lys Leu Gln Leu Ser Lys Asp Thr Tyr Asp 
            260                 265                 270         


Asp Asp Leu Asp Asn Leu Leu Ala Gln Ile Gly Asp Gln Tyr Ala Asp 
        275                 280                 285             


Leu Phe Leu Ala Ala Lys Asn Leu Ser Asp Ala Ile Leu Leu Ser Asp 
    290                 295                 300                 


Ile Leu Arg Val Asn Thr Glu Ile Thr Lys Ala Pro Leu Ser Ala Ser 
305                 310                 315                 320 


Met Ile Lys Arg Tyr Asp Glu His His Gln Asp Leu Thr Leu Leu Lys 
                325                 330                 335     


Ala Leu Val Arg Gln Gln Leu Pro Glu Lys Tyr Lys Glu Ile Phe Phe 
            340                 345                 350         


Asp Gln Ser Lys Asn Gly Tyr Ala Gly Tyr Ile Asp Gly Gly Ala Ser 
        355                 360                 365             


Gln Glu Glu Phe Tyr Lys Phe Ile Lys Pro Ile Leu Glu Lys Met Asp 
    370                 375                 380                 


Gly Thr Glu Glu Leu Leu Val Lys Leu Asn Arg Glu Asp Leu Leu Arg 
385                 390                 395                 400 


Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln Ile His Leu 
                405                 410                 415     


Gly Glu Leu His Ala Ile Leu Arg Arg Gln Glu Asp Phe Tyr Pro Phe 
            420                 425                 430         


Leu Lys Asp Asn Arg Glu Lys Ile Glu Lys Ile Leu Thr Phe Arg Ile 
        435                 440                 445             


Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly Asn Ser Arg Phe Ala Trp 
    450                 455                 460                 


Met Thr Arg Lys Ser Glu Glu Thr Ile Thr Pro Trp Asn Phe Glu Glu 
465                 470                 475                 480 


Val Val Asp Lys Gly Ala Ser Ala Gln Ser Phe Ile Glu Arg Met Thr 
                485                 490                 495     


Asn Phe Asp Lys Asn Leu Pro Asn Glu Lys Val Leu Pro Lys His Ser 
            500                 505                 510         


Leu Leu Tyr Glu Tyr Phe Thr Val Tyr Asn Glu Leu Thr Lys Val Lys 
        515                 520                 525             


Tyr Val Thr Glu Gly Met Arg Lys Pro Ala Phe Leu Ser Gly Glu Gln 
    530                 535                 540                 


Lys Lys Ala Ile Val Asp Leu Leu Phe Lys Thr Asn Arg Lys Val Thr 
545                 550                 555                 560 


Val Lys Gln Leu Lys Glu Asp Tyr Phe Lys Lys Ile Glu Cys Phe Asp 
                565                 570                 575     


Ser Val Glu Ile Ser Gly Val Glu Asp Arg Phe Asn Ala Ser Leu Gly 
            580                 585                 590         


Thr Tyr His Asp Leu Leu Lys Ile Ile Lys Asp Lys Asp Phe Leu Asp 
        595                 600                 605             


Asn Glu Glu Asn Glu Asp Ile Leu Glu Asp Ile Val Leu Thr Leu Thr 
    610                 615                 620                 


Leu Phe Glu Asp Arg Glu Met Ile Glu Glu Arg Leu Lys Thr Tyr Ala 
625                 630                 635                 640 


His Leu Phe Asp Asp Lys Val Met Lys Gln Leu Lys Arg Arg Arg Tyr 
                645                 650                 655     


Thr Gly Trp Gly Arg Leu Ser Arg Lys Leu Ile Asn Gly Ile Arg Asp 
            660                 665                 670         


Lys Gln Ser Gly Lys Thr Ile Leu Asp Phe Leu Lys Ser Asp Gly Phe 
        675                 680                 685             


Ala Asn Arg Asn Phe Met Gln Leu Ile His Asp Asp Ser Leu Thr Phe 
    690                 695                 700                 


Lys Glu Asp Ile Gln Lys Ala Gln Val Ser Gly Gln Gly Asp Ser Leu 
705                 710                 715                 720 


His Glu His Ile Ala Asn Leu Ala Gly Ser Pro Ala Ile Lys Lys Gly 
                725                 730                 735     


Ile Leu Gln Thr Val Lys Val Val Asp Glu Leu Val Lys Val Met Gly 
            740                 745                 750         


Arg His Lys Pro Glu Asn Ile Val Ile Glu Met Ala Arg Glu Asn Gln 
        755                 760                 765             


Thr Thr Gln Lys Gly Gln Lys Asn Ser Arg Glu Arg Met Lys Arg Ile 
    770                 775                 780                 


Glu Glu Gly Ile Lys Glu Leu Gly Ser Gln Ile Leu Lys Glu His Pro 
785                 790                 795                 800 


Val Glu Asn Thr Gln Leu Gln Asn Glu Lys Leu Tyr Leu Tyr Tyr Leu 
                805                 810                 815     


Gln Asn Gly Arg Asp Met Tyr Val Asp Gln Glu Leu Asp Ile Asn Arg 
            820                 825                 830         


Leu Ser Asp Tyr Asp Val Asp His Ile Val Pro Gln Ser Phe Leu Lys 
        835                 840                 845             


Asp Asp Ser Ile Asp Asn Lys Val Leu Thr Arg Ser Asp Lys Asn Arg 
    850                 855                 860                 


Gly Lys Ser Asp Asn Val Pro Ser Glu Glu Val Val Lys Lys Met Lys 
865                 870                 875                 880 


Asn Tyr Trp Arg Gln Leu Leu Asn Ala Lys Leu Ile Thr Gln Arg Lys 
                885                 890                 895     


Phe Asp Asn Leu Thr Lys Ala Glu Arg Gly Gly Leu Ser Glu Leu Asp 
            900                 905                 910         


Lys Ala Gly Phe Ile Lys Arg Gln Leu Val Glu Thr Arg Gln Ile Thr 
        915                 920                 925             


Lys His Val Ala Gln Ile Leu Asp Ser Arg Met Asn Thr Lys Tyr Asp 
    930                 935                 940                 


Glu Asn Asp Lys Leu Ile Arg Glu Val Lys Val Ile Thr Leu Lys Ser 
945                 950                 955                 960 


Lys Leu Val Ser Asp Phe Arg Lys Asp Phe Gln Phe Tyr Lys Val Arg 
                965                 970                 975     


Glu Ile Asn Asn Tyr His His Ala His Asp Ala Tyr Leu Asn Ala Val 
            980                 985                 990         


Val Gly Thr Ala Leu Ile Lys Lys  Tyr Pro Lys Leu Glu  Ser Glu Phe 
        995                 1000                 1005             


Val Tyr  Gly Asp Tyr Lys Val  Tyr Asp Val Arg Lys  Met Ile Ala 
    1010                 1015                 1020             


Lys Ser  Glu Gln Glu Ile Gly  Lys Ala Thr Ala Lys  Tyr Phe Phe 
    1025                 1030                 1035             


Tyr Ser  Asn Ile Met Asn Phe  Phe Lys Thr Glu Ile  Thr Leu Ala 
    1040                 1045                 1050             


Asn Gly  Glu Ile Arg Lys Arg  Pro Leu Ile Glu Thr  Asn Gly Glu 
    1055                 1060                 1065             


Thr Gly  Glu Ile Val Trp Asp  Lys Gly Arg Asp Phe  Ala Thr Val 
    1070                 1075                 1080             


Arg Lys  Val Leu Ser Met Pro  Gln Val Asn Ile Val  Lys Lys Thr 
    1085                 1090                 1095             


Glu Val  Gln Thr Gly Gly Phe  Ser Lys Glu Ser Ile  Leu Pro Lys 
    1100                 1105                 1110             


Arg Asn  Ser Asp Lys Leu Ile  Ala Arg Lys Lys Asp  Trp Asp Pro 
    1115                 1120                 1125             


Lys Lys  Tyr Gly Gly Phe Val  Ser Pro Thr Val Ala  Tyr Ser Val 
    1130                 1135                 1140             


Leu Val  Val Ala Lys Val Glu  Lys Gly Lys Ser Lys  Lys Leu Lys 
    1145                 1150                 1155             


Ser Val  Lys Glu Leu Leu Gly  Ile Thr Ile Met Glu  Arg Ser Ser 
    1160                 1165                 1170             


Phe Glu  Lys Asn Pro Ile Asp  Phe Leu Glu Ala Lys  Gly Tyr Lys 
    1175                 1180                 1185             


Glu Val  Lys Lys Asp Leu Ile  Ile Lys Leu Pro Lys  Tyr Ser Leu 
    1190                 1195                 1200             


Phe Glu  Leu Glu Asn Gly Arg  Lys Arg Met Leu Ala  Ser Ala Arg 
    1205                 1210                 1215             


Glu Leu  Gln Lys Gly Asn Glu  Leu Ala Leu Pro Ser  Lys Tyr Val 
    1220                 1225                 1230             


Asn Phe  Leu Tyr Leu Ala Ser  His Tyr Glu Lys Leu  Lys Gly Ser 
    1235                 1240                 1245             


Pro Glu  Asp Asn Glu Gln Lys  Gln Leu Phe Val Glu  Gln His Lys 
    1250                 1255                 1260             


His Tyr  Leu Asp Glu Ile Ile  Glu Gln Ile Ser Glu  Phe Ser Lys 
    1265                 1270                 1275             


Arg Val  Ile Leu Ala Asp Ala  Asn Leu Asp Lys Val  Leu Ser Ala 
    1280                 1285                 1290             


Tyr Asn  Lys His Arg Asp Lys  Pro Ile Arg Glu Gln  Ala Glu Asn 
    1295                 1300                 1305             


Ile Ile  His Leu Phe Thr Leu  Thr Asn Leu Gly Ala  Pro Ala Ala 
    1310                 1315                 1320             


Phe Lys  Tyr Phe Asp Thr Thr  Ile Asp Arg Lys Glu  Tyr Arg Ser 
    1325                 1330                 1335             


Thr Lys  Glu Val Leu Asp Ala  Thr Leu Ile His Gln  Ser Ile Thr 
    1340                 1345                 1350             


Gly Leu  Tyr Glu Thr Arg Ile  Asp Leu Ser Gln Leu  Gly Gly Asp 
    1355                 1360                 1365             


<210>  32
<211>  3159
<212>  DNA
<213>  Staphylococcus aureus

<400>  32
atgaaaagga actacattct ggggctggac atcgggatta caagcgtggg gtatgggatt       60

attgactatg aaacaaggga cgtgatcgac gcaggcgtca gactgttcaa ggaggccaac      120

gtggaaaaca atgagggacg gagaagcaag aggggagcca ggcgcctgaa acgacggaga      180

aggcacagaa tccagagggt gaagaaactg ctgttcgatt acaacctgct gaccgaccat      240

tctgagctga gtggaattaa tccttatgaa gccagggtga aaggcctgag tcagaagctg      300

tcagaggaag agttttccgc agctctgctg cacctggcta agcgccgagg agtgcataac      360

gtcaatgagg tggaagagga caccggcaac gagctgtcta caaaggaaca gatctcacgc      420

aatagcaaag ctctggaaga gaagtatgtc gcagagctgc agctggaacg gctgaagaaa      480

gatggcgagg tgagagggtc aattaatagg ttcaagacaa gcgactacgt caaagaagcc      540

aagcagctgc tgaaagtgca gaaggcttac caccagctgg atcagagctt catcgatact      600

tatatcgacc tgctggagac tcggagaacc tactatgagg gaccaggaga agggagcccc      660

ttcggatgga aagacatcaa ggaatggtac gagatgctga tgggacattg cacctatttt      720

ccagaagagc tgagaagcgt caagtacgct tataacgcag atctgtacaa cgccctgaat      780

gacctgaaca acctggtcat caccagggat gaaaacgaga aactggaata ctatgagaag      840

ttccagatca tcgaaaacgt gtttaagcag aagaaaaagc ctacactgaa acagattgct      900

aaggagatcc tggtcaacga agaggacatc aagggctacc gggtgacaag cactggaaaa      960

ccagagttca ccaatctgaa agtgtatcac gatattaagg acatcacagc acggaaagaa     1020

atcattgaga acgccgaact gctggatcag attgctaaga tcctgactat ctaccagagc     1080

tccgaggaca tccaggaaga gctgactaac ctgaacagcg agctgaccca ggaagagatc     1140

gaacagatta gtaatctgaa ggggtacacc ggaacacaca acctgtccct gaaagctatc     1200

aatctgattc tggatgagct gtggcataca aacgacaatc agattgcaat ctttaaccgg     1260

ctgaagctgg tcccaaaaaa ggtggacctg agtcagcaga aagagatccc aaccacactg     1320

gtggacgatt tcattctgtc acccgtggtc aagcggagct tcatccagag catcaaagtg     1380

atcaacgcca tcatcaagaa gtacggcctg cccaatgata tcattatcga gctggctagg     1440

gagaagaaca gcaaggacgc acagaagatg atcaatgaga tgcagaaacg aaaccggcag     1500

accaatgaac gcattgaaga gattatccga actaccggga aagagaacgc aaagtacctg     1560

attgaaaaaa tcaagctgca cgatatgcag gagggaaagt gtctgtattc tctggaggcc     1620

atccccctgg aggacctgct gaacaatcca ttcaactacg aggtcgatca tattatcccc     1680

agaagcgtgt ccttcgacaa ttcctttaac aacaaggtgc tggtcaagca ggaagagaac     1740

tctaaaaagg gcaataggac tcctttccag tacctgtcta gttcagattc caagatctct     1800

tacgaaacct ttaaaaagca cattctgaat ctggccaaag gaaagggccg catcagcaag     1860

accaaaaagg agtacctgct ggaagagcgg gacatcaaca gattctccgt ccagaaggat     1920

tttattaacc ggaatctggt ggacacaaga tacgctactc gcggcctgat gaatctgctg     1980

cgatcctatt tccgggtgaa caatctggat gtgaaagtca agtccatcaa cggcgggttc     2040

acatcttttc tgaggcgcaa atggaagttt aaaaaggagc gcaacaaagg gtacaagcac     2100

catgccgaag atgctctgat tatcgcaaat gccgacttca tctttaagga gtggaaaaag     2160

ctggacaaag ccaagaaagt gatggagaac cagatgttcg aagagaagca ggccgaatct     2220

atgcccgaaa tcgagacaga acaggagtac aaggagattt tcatcactcc tcaccagatc     2280

aagcatatca aggatttcaa ggactacaag tactctcacc gggtggataa aaagcccaac     2340

agagagctga tcaatgacac cctgtatagt acaagaaaag acgataaggg gaataccctg     2400

attgtgaaca atctgaacgg actgtacgac aaagataatg acaagctgaa aaagctgatc     2460

aacaaaagtc ccgagaagct gctgatgtac caccatgatc ctcagacata tcagaaactg     2520

aagctgatta tggagcagta cggcgacgag aagaacccac tgtataagta ctatgaagag     2580

actgggaact acctgaccaa gtatagcaaa aaggataatg gccccgtgat caagaagatc     2640

aagtactatg ggaacaagct gaatgcccat ctggacatca cagacgatta ccctaacagt     2700

cgcaacaagg tggtcaagct gtcactgaag ccatacagat tcgatgtcta tctggacaac     2760

ggcgtgtata aatttgtgac tgtcaagaat ctggatgtca tcaaaaagga gaactactat     2820

gaagtgaata gcaagtgcta cgaagaggct aaaaagctga aaaagattag caaccaggca     2880

gagttcatcg cctcctttta caacaacgac ctgattaaga tcaatggcga actgtatagg     2940

gtcatcgggg tgaacaatga tctgctgaac cgcattgaag tgaatatgat tgacatcact     3000

taccgagagt atctggaaaa catgaatgat aagcgccccc ctcgaattat caaaacaatt     3060

gcctctaaga ctcagagtat caaaaagtac tcaaccgaca ttctgggaaa cctgtatgag     3120

gtgaagagca aaaagcaccc tcagattatc aaaaagggc                            3159


<210>  33
<211>  3159
<212>  DNA
<213>  Staphylococcus aureus

<400>  33
atgaagcgga actacatcct gggcctggac atcggcatca ccagcgtggg ctacggcatc       60

atcgactacg agacacggga cgtgatcgat gccggcgtgc ggctgttcaa agaggccaac      120

gtggaaaaca acgagggcag gcggagcaag agaggcgcca gaaggctgaa gcggcggagg      180

cggcatagaa tccagagagt gaagaagctg ctgttcgact acaacctgct gaccgaccac      240

agcgagctga gcggcatcaa cccctacgag gccagagtga agggcctgag ccagaagctg      300

agcgaggaag agttctctgc cgccctgctg cacctggcca agagaagagg cgtgcacaac      360

gtgaacgagg tggaagagga caccggcaac gagctgtcca ccaaagagca gatcagccgg      420

aacagcaagg ccctggaaga gaaatacgtg gccgaactgc agctggaacg gctgaagaaa      480

gacggcgaag tgcggggcag catcaacaga ttcaagacca gcgactacgt gaaagaagcc      540

aaacagctgc tgaaggtgca gaaggcctac caccagctgg accagagctt catcgacacc      600

tacatcgacc tgctggaaac ccggcggacc tactatgagg gacctggcga gggcagcccc      660

ttcggctgga aggacatcaa agaatggtac gagatgctga tgggccactg cacctacttc      720

cccgaggaac tgcggagcgt gaagtacgcc tacaacgccg acctgtacaa cgccctgaac      780

gacctgaaca atctcgtgat caccagggac gagaacgaga agctggaata ttacgagaag      840

ttccagatca tcgagaacgt gttcaagcag aagaagaagc ccaccctgaa gcagatcgcc      900

aaagaaatcc tcgtgaacga agaggatatt aagggctaca gagtgaccag caccggcaag      960

cccgagttca ccaacctgaa ggtgtaccac gacatcaagg acattaccgc ccggaaagag     1020

attattgaga acgccgagct gctggatcag attgccaaga tcctgaccat ctaccagagc     1080

agcgaggaca tccaggaaga actgaccaat ctgaactccg agctgaccca ggaagagatc     1140

gagcagatct ctaatctgaa gggctatacc ggcacccaca acctgagcct gaaggccatc     1200

aacctgatcc tggacgagct gtggcacacc aacgacaacc agatcgctat cttcaaccgg     1260

ctgaagctgg tgcccaagaa ggtggacctg tcccagcaga aagagatccc caccaccctg     1320

gtggacgact tcatcctgag ccccgtcgtg aagagaagct tcatccagag catcaaagtg     1380

atcaacgcca tcatcaagaa gtacggcctg cccaacgaca tcattatcga gctggcccgc     1440

gagaagaact ccaaggacgc ccagaaaatg atcaacgaga tgcagaagcg gaaccggcag     1500

accaacgagc ggatcgagga aatcatccgg accaccggca aagagaacgc caagtacctg     1560

atcgagaaga tcaagctgca cgacatgcag gaaggcaagt gcctgtacag cctggaagcc     1620

atccctctgg aagatctgct gaacaacccc ttcaactatg aggtggacca catcatcccc     1680

agaagcgtgt ccttcgacaa cagcttcaac aacaaggtgc tcgtgaagca ggaagaaaac     1740

agcaagaagg gcaaccggac cccattccag tacctgagca gcagcgacag caagatcagc     1800

tacgaaacct tcaagaagca catcctgaat ctggccaagg gcaagggcag aatcagcaag     1860

accaagaaag agtatctgct ggaagaacgg gacatcaaca ggttctccgt gcagaaagac     1920

ttcatcaacc ggaacctggt ggataccaga tacgccacca gaggcctgat gaacctgctg     1980

cggagctact tcagagtgaa caacctggac gtgaaagtga agtccatcaa tggcggcttc     2040

accagctttc tgcggcggaa gtggaagttt aagaaagagc ggaacaaggg gtacaagcac     2100

cacgccgagg acgccctgat cattgccaac gccgatttca tcttcaaaga gtggaagaaa     2160

ctggacaagg ccaaaaaagt gatggaaaac cagatgttcg aggaaaagca ggccgagagc     2220

atgcccgaga tcgaaaccga gcaggagtac aaagagatct tcatcacccc ccaccagatc     2280

aagcacatta aggacttcaa ggactacaag tacagccacc gggtggacaa gaagcctaat     2340

agagagctga ttaacgacac cctgtactcc acccggaagg acgacaaggg caacaccctg     2400

atcgtgaaca atctgaacgg cctgtacgac aaggacaatg acaagctgaa aaagctgatc     2460

aacaagagcc ccgaaaagct gctgatgtac caccacgacc cccagaccta ccagaaactg     2520

aagctgatta tggaacagta cggcgacgag aagaatcccc tgtacaagta ctacgaggaa     2580

accgggaact acctgaccaa gtactccaaa aaggacaacg gccccgtgat caagaagatt     2640

aagtattacg gcaacaaact gaacgcccat ctggacatca ccgacgacta ccccaacagc     2700

agaaacaagg tcgtgaagct gtccctgaag ccctacagat tcgacgtgta cctggacaat     2760

ggcgtgtaca agttcgtgac cgtgaagaat ctggatgtga tcaaaaaaga aaactactac     2820

gaagtgaata gcaagtgcta tgaggaagct aagaagctga agaagatcag caaccaggcc     2880

gagtttatcg cctccttcta caacaacgat ctgatcaaga tcaacggcga gctgtataga     2940

gtgatcggcg tgaacaacga cctgctgaac cggatcgaag tgaacatgat cgacatcacc     3000

taccgcgagt acctggaaaa catgaacgac aagaggcccc ccaggatcat taagacaatc     3060

gcctccaaga cccagagcat taagaagtac agcacagaca ttctgggcaa cctgtatgaa     3120

gtgaaatcta agaagcaccc tcagatcatc aaaaagggc                            3159


<210>  34
<211>  3159
<212>  DNA
<213>  Staphylococcus aureus

<400>  34
atgaagcgca actacatcct cggactggac atcggcatta cctccgtggg atacggcatc       60

atcgattacg aaactaggga tgtgatcgac gctggagtca ggctgttcaa agaggcgaac      120

gtggagaaca acgaggggcg gcgctcaaag aggggggccc gccggctgaa gcgccgccgc      180

agacatagaa tccagcgcgt gaagaagctg ctgttcgact acaaccttct gaccgaccac      240

tccgaacttt ccggcatcaa cccatatgag gctagagtga agggattgtc ccaaaagctg      300

tccgaggaag agttctccgc cgcgttgctc cacctcgcca agcgcagggg agtgcacaat      360

gtgaacgaag tggaagaaga taccggaaac gagctgtcca ccaaggagca gatcagccgg      420

aactccaagg ccctggaaga gaaatacgtg gcggaactgc aactggagcg gctgaagaaa      480

gacggagaag tgcgcggctc gatcaaccgc ttcaagacct cggactacgt gaaggaggcc      540

aagcagctcc tgaaagtgca aaaggcctat caccaacttg accagtcctt tatcgatacc      600

tacatcgatc tgctcgagac tcggcggact tactacgagg gtccagggga gggctcccca      660

tttggttgga aggatattaa ggagtggtac gaaatgctga tgggacactg cacatacttc      720

cctgaggagc tgcggagcgt gaaatacgca tacaacgcag acctgtacaa cgcgctgaac      780

gacctgaaca atctcgtgat cacccgggac gagaacgaaa agctcgagta ttacgaaaag      840

ttccagatta ttgagaacgt gttcaaacag aagaagaagc cgacactgaa gcagattgcc      900

aaggaaatcc tcgtgaacga agaggacatc aagggctatc gagtgacctc aacgggaaag      960

ccggagttca ccaatctgaa ggtctaccac gacatcaaag acattaccgc ccggaaggag     1020

atcattgaga acgcggagct gttggaccag attgcgaaga ttctgaccat ctaccaatcc     1080

tccgaggata ttcaggaaga actcaccaac ctcaacagcg aactgaccca ggaggagata     1140

gagcaaatct ccaacctgaa gggctacacc ggaactcata acctgagcct gaaggccatc     1200

aacttgatcc tggacgagct gtggcacacc aacgataacc agatcgctat tttcaatcgg     1260

ctgaagctgg tccccaagaa agtggacctc tcacaacaaa aggagatccc tactaccctt     1320

gtggacgatt tcattctgtc ccccgtggtc aagagaagct tcatacagtc aatcaaagtg     1380

atcaatgcca ttatcaagaa atacggtctg cccaacgaca ttatcattga gctcgcccgc     1440

gagaagaact cgaaggacgc ccagaagatg attaacgaaa tgcagaagag gaaccgacag     1500

actaacgaac ggatcgaaga aatcatccgg accaccggga aggaaaacgc gaagtacctg     1560

atcgaaaaga tcaagctcca tgacatgcag gaaggaaagt gtctgtactc gctggaggcc     1620

attccgctgg aggacttgct gaacaaccct tttaactacg aagtggatca tatcattccg     1680

aggagcgtgt cattcgacaa ttccttcaac aacaaggtcc tcgtgaagca ggaggaaaac     1740

tcgaagaagg gaaaccgcac gccgttccag tacctgagca gcagcgactc caagatttcc     1800

tacgaaacct tcaagaagca catcctcaac ctggcaaagg ggaagggtcg catctccaag     1860

accaagaagg aatatctgct ggaagaaaga gacatcaaca gattctccgt gcaaaaggac     1920

ttcatcaacc gcaacctcgt ggatactaga tacgctactc ggggtctgat gaacctcctg     1980

agaagctact ttagagtgaa caatctggac gtgaaggtca agtcgattaa cggaggtttc     2040

acctccttcc tgcggcgcaa gtggaagttc aagaaggaac ggaacaaggg ctacaagcac     2100

cacgccgagg acgccctgat cattgccaac gccgacttca tcttcaaaga atggaagaaa     2160

cttgacaagg ctaagaaggt catggaaaac cagatgttcg aagaaaagca ggccgagtct     2220

atgcctgaaa tcgagactga acaggagtac aaggaaatct ttattacgcc acaccagatc     2280

aaacacatca aggatttcaa ggattacaag tactcacatc gcgtggacaa aaagccgaac     2340

agggaactga tcaacgacac cctctactcc acccggaagg atgacaaagg gaataccctc     2400

atcgtcaaca accttaacgg cctgtacgac aaggacaacg ataagctgaa gaagctcatt     2460

aacaagtcgc ccgaaaagtt gctgatgtac caccacgacc ctcagactta ccagaagctc     2520

aagctgatca tggagcagta tggggacgag aaaaacccgt tgtacaagta ctacgaagaa     2580

actgggaatt atctgactaa gtactccaag aaagataacg gccccgtgat taagaagatt     2640

aagtactacg gcaacaagct gaacgcccat ctggacatca ccgatgacta ccctaattcc     2700

cgcaacaagg tcgtcaagct gagcctcaag ccctaccggt ttgatgtgta ccttgacaat     2760

ggagtgtaca agttcgtgac tgtgaagaac cttgacgtga tcaagaagga gaactactac     2820

gaagtcaact ccaagtgcta cgaggaagca aagaagttga agaagatctc gaaccaggcc     2880

gagttcattg cctccttcta taacaacgac ctgattaaga tcaacggcga actgtaccgc     2940

gtcattggcg tgaacaacga tctcctgaac cgcatcgaag tgaacatgat cgacatcact     3000

taccgggaat acctggagaa tatgaacgac aagcgcccgc cccggatcat taagactatc     3060

gcctcaaaga cccagtcgat caagaagtac agcaccgaca tcctgggcaa cctgtacgag     3120

gtcaaatcga agaagcaccc ccagatcatc aagaaggga                            3159


<210>  35
<211>  3255
<212>  DNA
<213>  Staphylococcus aureus

<400>  35
atggccccaa agaagaagcg gaaggtcggt atccacggag tcccagcagc caagcggaac       60

tacatcctgg gcctggacat cggcatcacc agcgtgggct acggcatcat cgactacgag      120

acacgggacg tgatcgatgc cggcgtgcgg ctgttcaaag aggccaacgt ggaaaacaac      180

gagggcaggc ggagcaagag aggcgccaga aggctgaagc ggcggaggcg gcatagaatc      240

cagagagtga agaagctgct gttcgactac aacctgctga ccgaccacag cgagctgagc      300

ggcatcaacc cctacgaggc cagagtgaag ggcctgagcc agaagctgag cgaggaagag      360

ttctctgccg ccctgctgca cctggccaag agaagaggcg tgcacaacgt gaacgaggtg      420

gaagaggaca ccggcaacga gctgtccacc agagagcaga tcagccggaa cagcaaggcc      480

ctggaagaga aatacgtggc cgaactgcag ctggaacggc tgaagaaaga cggcgaagtg      540

cggggcagca tcaacagatt caagaccagc gactacgtga aagaagccaa acagctgctg      600

aaggtgcaga aggcctacca ccagctggac cagagcttca tcgacaccta catcgacctg      660

ctggaaaccc ggcggaccta ctatgaggga cctggcgagg gcagcccctt cggctggaag      720

gacatcaaag aatggtacga gatgctgatg ggccactgca cctacttccc cgaggaactg      780

cggagcgtga agtacgccta caacgccgac ctgtacaacg ccctgaacga cctgaacaat      840

ctcgtgatca ccagggacga gaacgagaag ctggaatatt acgagaagtt ccagatcatc      900

gagaacgtgt tcaagcagaa gaagaagccc accctgaagc agatcgccaa agaaatcctc      960

gtgaacgaag aggatattaa gggctacaga gtgaccagca ccggcaagcc cgagttcacc     1020

aacctgaagg tgtaccacga catcaaggac attaccgccc ggaaagagat tattgagaac     1080

gccgagctgc tggatcagat tgccaagatc ctgaccatct accagagcag cgaggacatc     1140

caggaagaac tgaccaatct gaactccgag ctgacccagg aagagatcga gcagatctct     1200

aatctgaagg gctataccgg cacccacaac ctgagcctga aggccatcaa cctgatcctg     1260

gacgagctgt ggcacaccaa cgacaaccag atcgctatct tcaaccggct gaagctggtg     1320

cccaagaagg tggacctgtc ccagcagaaa gagatcccca ccaccctggt ggacgacttc     1380

atcctgagcc ccgtcgtgaa gagaagcttc atccagagca tcaaagtgat caacgccatc     1440

atcaagaagt acggcctgcc caacgacatc attatcgagc tggcccgcga gaagaactcc     1500

aaggacgccc agaaaatgat caacgagatg cagaagcgga accggcagac caacgagcgg     1560

atcgaggaaa tcatccggac caccggcaaa gagaacgcca agtacctgat cgagaagatc     1620

aagctgcacg acatgcagga aggcaagtgc ctgtacagcc tggaagccat ccctctggaa     1680

gatctgctga acaacccctt caactatgag gtggaccaca tcatccccag aagcgtgtcc     1740

ttcgacaaca gcttcaacaa caaggtgctc gtgaagcagg aagaaaacag caagaagggc     1800

aaccggaccc cattccagta cctgagcagc agcgacagca agatcagcta cgaaaccttc     1860

aagaagcaca tcctgaatct ggccaagggc aagggcagaa tcagcaagac caagaaagag     1920

tatctgctgg aagaacggga catcaacagg ttctccgtgc agaaagactt catcaaccgg     1980

aacctggtgg ataccagata cgccaccaga ggcctgatga acctgctgcg gagctacttc     2040

agagtgaaca acctggacgt gaaagtgaag tccatcaatg gcggcttcac cagctttctg     2100

cggcggaagt ggaagtttaa gaaagagcgg aacaaggggt acaagcacca cgccgaggac     2160

gccctgatca ttgccaacgc cgatttcatc ttcaaagagt ggaagaaact ggacaaggcc     2220

aaaaaagtga tggaaaacca gatgttcgag gaaaggcagg ccgagagcat gcccgagatc     2280

gaaaccgagc aggagtacaa agagatcttc atcacccccc accagatcaa gcacattaag     2340

gacttcaagg actacaagta cagccaccgg gtggacaaga agcctaatag agagctgatt     2400

aacgacaccc tgtactccac ccggaaggac gacaagggca acaccctgat cgtgaacaat     2460

ctgaacggcc tgtacgacaa ggacaatgac aagctgaaaa agctgatcaa caagagcccc     2520

gaaaagctgc tgatgtacca ccacgacccc cagacctacc agaaactgaa gctgattatg     2580

gaacagtacg gcgacgagaa gaatcccctg tacaagtact acgaggaaac cgggaactac     2640

ctgaccaagt actccaaaaa ggacaacggc cccgtgatca agaagattaa gtattacggc     2700

aacaaactga acgcccatct ggacatcacc gacgactacc ccaacagcag aaacaaggtc     2760

gtgaagctgt ccctgaagcc ctacagattc gacgtgtacc tggacaatgg cgtgtacaag     2820

ttcgtgaccg tgaagaatct ggatgtgatc aaaaaagaaa actactacga agtgaatagc     2880

aagtgctatg aggaagctaa gaagctgaag aagatcagca accaggccga gtttatcgcc     2940

tccttctaca acaacgatct gatcaagatc aacggcgagc tgtatagagt gatcggcgtg     3000

aacaacgacc tgctgaaccg gatcgaagtg aacatgatcg acatcaccta ccgcgagtac     3060

ctggaaaaca tgaacgacaa gaggcccccc aggatcatta agacaatcgc ctccaagacc     3120

cagagcatta agaagtacag cacagacatt ctgggcaacc tgtatgaagt gaaatctaag     3180

aagcaccctc agatcatcaa aaagggcaaa aggccggcgg ccacgaaaaa ggccggccag     3240

gcaaaaaaga aaaag                                                      3255


<210>  36
<211>  3242
<212>  DNA
<213>  Staphylococcus aureus

<400>  36
accggtgcca ccatgtaccc atacgatgtt ccagattacg cttcgccgaa gaaaaagcgc       60

aaggtcgaag cgtccatgaa aaggaactac attctggggc tggacatcgg gattacaagc      120

gtggggtatg ggattattga ctatgaaaca agggacgtga tcgacgcagg cgtcagactg      180

ttcaaggagg ccaacgtgga aaacaatgag ggacggagaa gcaagagggg agccaggcgc      240

ctgaaacgac ggagaaggca cagaatccag agggtgaaga aactgctgtt cgattacaac      300

ctgctgaccg accattctga gctgagtgga attaatcctt atgaagccag ggtgaaaggc      360

ctgagtcaga agctgtcaga ggaagagttt tccgcagctc tgctgcacct ggctaagcgc      420

cgaggagtgc ataacgtcaa tgaggtggaa gaggacaccg gcaacgagct gtctacaaag      480

gaacagatct cacgcaatag caaagctctg gaagagaagt atgtcgcaga gctgcagctg      540

gaacggctga agaaagatgg cgaggtgaga gggtcaatta ataggttcaa gacaagcgac      600

tacgtcaaag aagccaagca gctgctgaaa gtgcagaagg cttaccacca gctggatcag      660

agcttcatcg atacttatat cgacctgctg gagactcgga gaacctacta tgagggacca      720

ggagaaggga gccccttcgg atggaaagac atcaaggaat ggtacgagat gctgatggga      780

cattgcacct attttccaga agagctgaga agcgtcaagt acgcttataa cgcagatctt      840

acaacgccct gaatgacctg aacaacctgg tcatcaccag ggatgaaaac gagaaactgg      900

aatactatga gaagttccag atcatcgaaa acgtgtttaa gcagaagaaa aagcctacac      960

tgaaacagat tgctaaggag atcctggtca acgaagagga catcaagggc taccgggtga     1020

caagcactgg aaaaccagag ttcaccaatc tgaaagtgta tcacgatatt aaggacatca     1080

cagcacggaa agaaatcatt gagaacgccg aactgctgga tcagattgct aagatcctga     1140

ctatctacca gagctccgag gacatccagg aagagctgac taacctgaac agcgagctga     1200

cccaggaaga gatcgaacag attagtaatc tgaaggggta caccggaaca cacaacctgt     1260

ccctgaaagc tatcaatctg attctggatg agctgtggca tacaaacgac aatcagattg     1320

caatctttaa ccggctgaag ctggtcccaa aaaaggtgga cctgagtcag cagaaagaga     1380

tcccaaccac actggtggac gatttcattc tgtcacccgt ggtcaagcgg agcttcatcc     1440

agagcatcaa agtgatcaac gccatcatca agaagtacgg cctgcccaat gatatcatta     1500

tcgagctggc tagggagaag aacagcaagg acgcacagaa gatgatcaat gagatgcaga     1560

aacgaaaccg gcagaccaat gaacgcattg aagagattat ccgaactacc gggaaagaga     1620

acgcaaagta cctgattgaa aaaatcaagc tgcacgatat gcaggaggga aagtgtctgt     1680

attctctgga ggccatcccc ctggaggacc tgctgaacaa tccattcaac tacgaggtcg     1740

atcatattat ccccagaagc gtgtccttcg acaattcctt taacaacaag gtgctggtca     1800

agcaggaaga gaactctaaa aagggcaata ggactccttt ccagtacctg tctagttcag     1860

attccaagat ctcttacgaa acctttaaaa agcacattct gaatctggcc aaaggaaagg     1920

gccgcatcag caagaccaaa aaggagtacc tgctggaaga gcgggacatc aacagattct     1980

ccgtccagaa ggattttatt aaccggaatc tggtggacac aagatacgct actcgcggcc     2040

tgatgaatct gctgcgatcc tatttccggg tgaacaatct ggatgtgaaa gtcaagtcca     2100

tcaacggcgg gttcacatct tttctgaggc gcaaatggaa gtttaaaaag gagcgcaaca     2160

aagggtacaa gcaccatgcc gaagatgctc tgattatcgc aaatgccgac ttcatcttta     2220

aggagtggaa aaagctggac aaagccaaga aagtgatgga gaaccagatg ttcgaagaga     2280

agcaggccga atctatgccc gaaatcgaga cagaacagga gtacaaggag attttcatca     2340

ctcctcacca gatcaagcat atcaaggatt tcaaggacta caagtactct caccgggtgg     2400

ataaaaagcc caacagagag ctgatcaatg acaccctgta tagtacaaga aaagacgata     2460

aggggaatac cctgattgtg aacaatctga acggactgta cgacaaagat aatgacaagc     2520

tgaaaaagct gatcaacaaa agtcccgaga agctgctgat gtaccaccat gatcctcaga     2580

catatcagaa actgaagctg attatggagc agtacggcga cgagaagaac ccactgtata     2640

agtactatga agagactggg aactacctga ccaagtatag caaaaaggat aatggccccg     2700

tgatcaagaa gatcaagtac tatgggaaca agctgaatgc ccatctggac atcacagacg     2760

attaccctaa cagtcgcaac aaggtggtca agctgtcact gaagccatac agattcgatg     2820

tctatctgga caacggcgtg tataaatttg tgactgtcaa gaatctggat gtcatcaaaa     2880

aggagaacta ctatgaagtg aatagcaagt gctacgaaga ggctaaaaag ctgaaaaaga     2940

ttagcaacca ggcagagttc atcgcctcct tttacaacaa cgacctgatt aagatcaatg     3000

gcgaactgta tagggtcatc ggggtgaaca atgatctgct gaaccgcatt gaagtgaata     3060

tgattgacat cacttaccga gagtatctgg aaaacatgaa tgataagcgc ccccctcgaa     3120

ttatcaaaac aattgcctct aagactcaga gtatcaaaaa gtactcaacc gacattctgg     3180

gaaacctgta tgaggtgaag agcaaaaagc accctcagat tatcaaaaag ggctaagaat     3240

tc                                                                    3242


<210>  37
<211>  1053
<212>  PRT
<213>  Staphylococcus aureus

<400>  37

Met Lys Arg Asn Tyr Ile Leu Gly Leu Asp Ile Gly Ile Thr Ser Val 
1               5                   10                  15      


Gly Tyr Gly Ile Ile Asp Tyr Glu Thr Arg Asp Val Ile Asp Ala Gly 
            20                  25                  30          


Val Arg Leu Phe Lys Glu Ala Asn Val Glu Asn Asn Glu Gly Arg Arg 
        35                  40                  45              


Ser Lys Arg Gly Ala Arg Arg Leu Lys Arg Arg Arg Arg His Arg Ile 
    50                  55                  60                  


Gln Arg Val Lys Lys Leu Leu Phe Asp Tyr Asn Leu Leu Thr Asp His 
65                  70                  75                  80  


Ser Glu Leu Ser Gly Ile Asn Pro Tyr Glu Ala Arg Val Lys Gly Leu 
                85                  90                  95      


Ser Gln Lys Leu Ser Glu Glu Glu Phe Ser Ala Ala Leu Leu His Leu 
            100                 105                 110         


Ala Lys Arg Arg Gly Val His Asn Val Asn Glu Val Glu Glu Asp Thr 
        115                 120                 125             


Gly Asn Glu Leu Ser Thr Lys Glu Gln Ile Ser Arg Asn Ser Lys Ala 
    130                 135                 140                 


Leu Glu Glu Lys Tyr Val Ala Glu Leu Gln Leu Glu Arg Leu Lys Lys 
145                 150                 155                 160 


Asp Gly Glu Val Arg Gly Ser Ile Asn Arg Phe Lys Thr Ser Asp Tyr 
                165                 170                 175     


Val Lys Glu Ala Lys Gln Leu Leu Lys Val Gln Lys Ala Tyr His Gln 
            180                 185                 190         


Leu Asp Gln Ser Phe Ile Asp Thr Tyr Ile Asp Leu Leu Glu Thr Arg 
        195                 200                 205             


Arg Thr Tyr Tyr Glu Gly Pro Gly Glu Gly Ser Pro Phe Gly Trp Lys 
    210                 215                 220                 


Asp Ile Lys Glu Trp Tyr Glu Met Leu Met Gly His Cys Thr Tyr Phe 
225                 230                 235                 240 


Pro Glu Glu Leu Arg Ser Val Lys Tyr Ala Tyr Asn Ala Asp Leu Tyr 
                245                 250                 255     


Asn Ala Leu Asn Asp Leu Asn Asn Leu Val Ile Thr Arg Asp Glu Asn 
            260                 265                 270         


Glu Lys Leu Glu Tyr Tyr Glu Lys Phe Gln Ile Ile Glu Asn Val Phe 
        275                 280                 285             


Lys Gln Lys Lys Lys Pro Thr Leu Lys Gln Ile Ala Lys Glu Ile Leu 
    290                 295                 300                 


Val Asn Glu Glu Asp Ile Lys Gly Tyr Arg Val Thr Ser Thr Gly Lys 
305                 310                 315                 320 


Pro Glu Phe Thr Asn Leu Lys Val Tyr His Asp Ile Lys Asp Ile Thr 
                325                 330                 335     


Ala Arg Lys Glu Ile Ile Glu Asn Ala Glu Leu Leu Asp Gln Ile Ala 
            340                 345                 350         


Lys Ile Leu Thr Ile Tyr Gln Ser Ser Glu Asp Ile Gln Glu Glu Leu 
        355                 360                 365             


Thr Asn Leu Asn Ser Glu Leu Thr Gln Glu Glu Ile Glu Gln Ile Ser 
    370                 375                 380                 


Asn Leu Lys Gly Tyr Thr Gly Thr His Asn Leu Ser Leu Lys Ala Ile 
385                 390                 395                 400 


Asn Leu Ile Leu Asp Glu Leu Trp His Thr Asn Asp Asn Gln Ile Ala 
                405                 410                 415     


Ile Phe Asn Arg Leu Lys Leu Val Pro Lys Lys Val Asp Leu Ser Gln 
            420                 425                 430         


Gln Lys Glu Ile Pro Thr Thr Leu Val Asp Asp Phe Ile Leu Ser Pro 
        435                 440                 445             


Val Val Lys Arg Ser Phe Ile Gln Ser Ile Lys Val Ile Asn Ala Ile 
    450                 455                 460                 


Ile Lys Lys Tyr Gly Leu Pro Asn Asp Ile Ile Ile Glu Leu Ala Arg 
465                 470                 475                 480 


Glu Lys Asn Ser Lys Asp Ala Gln Lys Met Ile Asn Glu Met Gln Lys 
                485                 490                 495     


Arg Asn Arg Gln Thr Asn Glu Arg Ile Glu Glu Ile Ile Arg Thr Thr 
            500                 505                 510         


Gly Lys Glu Asn Ala Lys Tyr Leu Ile Glu Lys Ile Lys Leu His Asp 
        515                 520                 525             


Met Gln Glu Gly Lys Cys Leu Tyr Ser Leu Glu Ala Ile Pro Leu Glu 
    530                 535                 540                 


Asp Leu Leu Asn Asn Pro Phe Asn Tyr Glu Val Asp His Ile Ile Pro 
545                 550                 555                 560 


Arg Ser Val Ser Phe Asp Asn Ser Phe Asn Asn Lys Val Leu Val Lys 
                565                 570                 575     


Gln Glu Glu Asn Ser Lys Lys Gly Asn Arg Thr Pro Phe Gln Tyr Leu 
            580                 585                 590         


Ser Ser Ser Asp Ser Lys Ile Ser Tyr Glu Thr Phe Lys Lys His Ile 
        595                 600                 605             


Leu Asn Leu Ala Lys Gly Lys Gly Arg Ile Ser Lys Thr Lys Lys Glu 
    610                 615                 620                 


Tyr Leu Leu Glu Glu Arg Asp Ile Asn Arg Phe Ser Val Gln Lys Asp 
625                 630                 635                 640 


Phe Ile Asn Arg Asn Leu Val Asp Thr Arg Tyr Ala Thr Arg Gly Leu 
                645                 650                 655     


Met Asn Leu Leu Arg Ser Tyr Phe Arg Val Asn Asn Leu Asp Val Lys 
            660                 665                 670         


Val Lys Ser Ile Asn Gly Gly Phe Thr Ser Phe Leu Arg Arg Lys Trp 
        675                 680                 685             


Lys Phe Lys Lys Glu Arg Asn Lys Gly Tyr Lys His His Ala Glu Asp 
    690                 695                 700                 


Ala Leu Ile Ile Ala Asn Ala Asp Phe Ile Phe Lys Glu Trp Lys Lys 
705                 710                 715                 720 


Leu Asp Lys Ala Lys Lys Val Met Glu Asn Gln Met Phe Glu Glu Lys 
                725                 730                 735     


Gln Ala Glu Ser Met Pro Glu Ile Glu Thr Glu Gln Glu Tyr Lys Glu 
            740                 745                 750         


Ile Phe Ile Thr Pro His Gln Ile Lys His Ile Lys Asp Phe Lys Asp 
        755                 760                 765             


Tyr Lys Tyr Ser His Arg Val Asp Lys Lys Pro Asn Arg Glu Leu Ile 
    770                 775                 780                 


Asn Asp Thr Leu Tyr Ser Thr Arg Lys Asp Asp Lys Gly Asn Thr Leu 
785                 790                 795                 800 


Ile Val Asn Asn Leu Asn Gly Leu Tyr Asp Lys Asp Asn Asp Lys Leu 
                805                 810                 815     


Lys Lys Leu Ile Asn Lys Ser Pro Glu Lys Leu Leu Met Tyr His His 
            820                 825                 830         


Asp Pro Gln Thr Tyr Gln Lys Leu Lys Leu Ile Met Glu Gln Tyr Gly 
        835                 840                 845             


Asp Glu Lys Asn Pro Leu Tyr Lys Tyr Tyr Glu Glu Thr Gly Asn Tyr 
    850                 855                 860                 


Leu Thr Lys Tyr Ser Lys Lys Asp Asn Gly Pro Val Ile Lys Lys Ile 
865                 870                 875                 880 


Lys Tyr Tyr Gly Asn Lys Leu Asn Ala His Leu Asp Ile Thr Asp Asp 
                885                 890                 895     


Tyr Pro Asn Ser Arg Asn Lys Val Val Lys Leu Ser Leu Lys Pro Tyr 
            900                 905                 910         


Arg Phe Asp Val Tyr Leu Asp Asn Gly Val Tyr Lys Phe Val Thr Val 
        915                 920                 925             


Lys Asn Leu Asp Val Ile Lys Lys Glu Asn Tyr Tyr Glu Val Asn Ser 
    930                 935                 940                 


Lys Cys Tyr Glu Glu Ala Lys Lys Leu Lys Lys Ile Ser Asn Gln Ala 
945                 950                 955                 960 


Glu Phe Ile Ala Ser Phe Tyr Asn Asn Asp Leu Ile Lys Ile Asn Gly 
                965                 970                 975     


Glu Leu Tyr Arg Val Ile Gly Val Asn Asn Asp Leu Leu Asn Arg Ile 
            980                 985                 990         


Glu Val Asn Met Ile Asp Ile Thr  Tyr Arg Glu Tyr Leu  Glu Asn Met 
        995                 1000                 1005             


Asn Asp  Lys Arg Pro Pro Arg  Ile Ile Lys Thr Ile  Ala Ser Lys 
    1010                 1015                 1020             


Thr Gln  Ser Ile Lys Lys Tyr  Ser Thr Asp Ile Leu  Gly Asn Leu 
    1025                 1030                 1035             


Tyr Glu  Val Lys Ser Lys Lys  His Pro Gln Ile Ile  Lys Lys Gly 
    1040                 1045                 1050             


<210>  38
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  38
gauauuuccu uguaacuagu                                                   20


<210>  39
<211>  6
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  n is a, c, g, or t

<400>  39
nngrrn                                                                   6


