                         SEQUENCE LISTING

<110>  LIAO, Chao-Wei
       CHEN, Chung-Chin
 
<120>  Fusion polypeptide for immuno-enhancement and method for 
       enhancing stimulation of immune response using the same

<130>  A0859/2060

<150>  62/412,896
<151>  2016-10-26

<160>  82    

<170>  PatentIn version 3.5

<210>  1
<211>  14
<212>  PRT
<213>  Homo sapiens

<400>  1

Ser Phe His Gln Leu Pro Ala Arg Ser Pro Ala Pro Leu Gln 
1               5                   10                  


<210>  2
<211>  22
<212>  PRT
<213>  Daedalea quercina Fr.

<400>  2

Ser Ser Phe His Leu Phe His His Leu Pro Ala Arg Ala Pro Leu Ala 
1               5                   10                  15      


Pro Ser Glu Leu Gln Pro 
            20          


<210>  3
<211>  17
<212>  PRT
<213>  Dasypus novemcinctus

<400>  3

Ser Thr Pro Phe His Pro Leu Pro Ala Arg Lys Pro Leu Pro Leu Gln 
1               5                   10                  15      


Pro 
    


<210>  4
<211>  212
<212>  PRT
<213>  Human papillomavirus

<400>  4

Glu Phe His Met Val Asp Gly Met Ser Ile Arg Ala Lys Arg Arg Lys 
1               5                   10                  15      


Arg Ala Ser Ala Thr Gln Leu Tyr Lys Thr Cys Lys Gln Ala Gly Thr 
            20                  25                  30          


Cys Pro Pro Asp Ile Ile Pro Lys Val Glu Gly Lys Thr Ile Ala Glu 
        35                  40                  45              


Gln Ile Leu Gln Tyr Gly Ser Met Gly Val Phe Phe Gly Gly Leu Gly 
    50                  55                  60                  


Ile Gly Thr Gly Ser Gly Thr Gly Gly Arg Thr Gly Tyr Ile Pro Leu 
65                  70                  75                  80  


Gly Thr Arg Pro Pro Thr Ala Thr Asp Thr Leu Ala Pro Val Arg Pro 
                85                  90                  95      


Pro Leu Thr Val Asp Pro Val Gly Pro Ser Asp Pro Ser Ile Val Ser 
            100                 105                 110         


Leu Val Glu Glu Thr Ser Phe Ile Asp Ala Gly Ala Pro Thr Ser Val 
        115                 120                 125             


Pro Ser Ile Pro Pro Asp Val Ser Gly Phe Ser Ile Thr Thr Ser Thr 
    130                 135                 140                 


Asp Thr Thr Pro Ala Ile Leu Asp Ile Asn Asn Asn Thr Val Thr Thr 
145                 150                 155                 160 


Val Thr Thr His Asn Asn Pro Thr Phe Thr Asp Pro Ser Val Leu Gln 
                165                 170                 175     


Pro Pro Thr Pro Ala Glu Thr Gly Gly His Phe Thr Leu Ser Ser Ser 
            180                 185                 190         


Thr Ile Ser Thr His Asn Tyr Glu Glu Ile Pro Met Asp Thr Lys Asp 
        195                 200                 205             


Glu Leu Leu Glu 
    210         


<210>  5
<211>  78
<212>  DNA
<213>  Artificial sequence

<220>
<223>  CO-1 DNA sequence

<400>  5
gaattcagca gctttcatct gttccaccat ctgccagcgc gtgcgccatt agcgccttct       60

gaattacagc ccctcgag                                                     78


<210>  6
<211>  78
<212>  DNA
<213>  Artificial sequence

<220>
<223>  DQ-2 DNA sequence

<400>  6
gaattcagca gctttcatct gttccaccat ctgccagcgc gtgcgccatt agcgccttct       60

gaattacagc ccctcgag                                                     78


<210>  7
<211>  63
<212>  DNA
<213>  Artificial sequence

<220>
<223>  RV-3 DNA sequence

<400>  7
gaattctcta ctcctttcca cccattgcct gcccgcaaac cattgcctct ggtgcccctc       60

gag                                                                     63


<210>  8
<211>  636
<212>  DNA
<213>  Human papillomavirus

<400>  8
gaattccata tggtcgacgg tatgtccatc cgtgctaaac gtcgtaaacg tgcttccgct       60

acccagctgt acaaaacctg caaacaggct ggtacctgcc cgccggacat catcccgaaa      120

gttgaaggta aaaccatcgc tgaacagatc ctgcaatacg gttctatggg tgttttcttc      180

ggcggtctgg gcatcggtac cggttccggt actggcggtc gtaccggtta catcccgctg      240

ggtacccgtc cgccgaccgc taccgacacc ctggctccgg ttcgtccgcc gctgaccgtt      300

gacccggttg gtccgtccga cccgtccatc gtttccctgg ttgaagaaac ctccttcatc      360

gacgctggtg ctccgacctc cgttccgtcc atcccgccgg acgtttccgg tttctccatc      420

accacctcca ccgacactac cccggctatc ctggacatca acaacaacac cgttactacc      480

gtaaccactc acaacaaccc gaccttcacc gacccgtccg ttctgcaacc gccgaccccg      540

gctgaaaccg gtggtcactt caccctgtcc tcttccacca tctccaccca caactacgaa      600

gaaatcccga tggacaccaa agacgaactg ctcgag                                636


<210>  9
<211>  47
<212>  PRT
<213>  Artificial sequence

<220>
<223>  fused peptide

<400>  9

Glu Phe Val Asp Gln Leu Leu Arg Arg Glu Val Phe Cys Gly Phe Arg 
1               5                   10                  15      


Asp Leu Val Tyr Asp Phe Ala Phe Ser Asp Leu Lys Leu Pro Gln Leu 
            20                  25                  30          


Cys Thr Glu Leu Lys Leu Pro Gln Leu Cys Thr Glu Leu Leu Glu 
        35                  40                  45          


<210>  10
<211>  96
<212>  PRT
<213>  Artificial sequence

<220>
<223>  fused peptide

<400>  10

Glu Phe Val Asp Lys Asp Glu Leu Arg Glu Val Tyr Asn Phe Ala Phe 
1               5                   10                  15      


Leu Leu Val Leu Arg Arg Glu Val Tyr Asp Lys Asp Glu Leu Leu Leu 
            20                  25                  30          


Leu Leu Glu Asp Arg Gln Leu Leu Arg Arg Glu Val Phe Cys Gly Phe 
        35                  40                  45              


Arg Asp Leu Leu Glu Asp Arg Val Tyr Asp Phe Ala Phe Ser Asp Leu 
    50                  55                  60                  


Lys Leu Pro Gln Leu Cys Thr Glu Leu Lys Leu Pro Gln Leu Cys Thr 
65                  70                  75                  80  


Glu Leu Lys Asp Glu Leu Lys Asp Glu Leu Val Leu Leu Leu Leu Glu 
                85                  90                  95      


<210>  11
<211>  51
<212>  PRT
<213>  Artificial sequence

<220>
<223>  fused peptide

<400>  11

Glu Phe Val Asp Gln Ala Glu Pro Asp Gln Ala Glu Pro Asp Arg Ala 
1               5                   10                  15      


Arg Ala His Tyr Asn Ile Arg Ala Arg Ala His Tyr Asn Ile Leu Arg 
            20                  25                  30          


Ala His Tyr Asn Ile Val Ile Phe Arg Ala His Tyr Asn Ile Val Ile 
        35                  40                  45              


Phe Leu Glu 
    50      


<210>  12
<211>  70
<212>  PRT
<213>  Artificial sequence

<220>
<223>  fused peptide

<400>  12

Glu Phe Val Asp Gln Ala Glu Pro Asp Gln Ala Glu Pro Asp Arg Asp 
1               5                   10                  15      


Glu Leu Val Leu Arg Ala Arg Ala His Tyr Asn Ile Arg Ala Arg Ala 
            20                  25                  30          


His Tyr Asn Ile Leu Glu Asp Arg Leu Leu Val Leu Arg Ala His Tyr 
        35                  40                  45              


Asn Ile Val Ile Phe Arg Ala His Tyr Asn Ile Val Ile Phe Lys Asp 
    50                  55                  60                  


Glu Leu Leu Val Leu Glu 
65                  70  


<210>  13
<211>  153
<212>  DNA
<213>  Artificial sequence

<220>
<223>  E601 DNA sequence

<400>  13
gaattcgtcg accaactgtt gcgtcgtgaa gttttctgtg gctttcgtga tctggtctat       60

gacttcgcct ttagtgattt gaagctgcca caattgtgta cggaactgaa actgcctcaa      120

ctgtgtacag aactgaagga tgagctgctc gag                                   153


<210>  14
<211>  288
<212>  DNA
<213>  Artificial sequence

<220>
<223>  E622 DNA sequence

<400>  14
gaattcgtcg acaaagatga actgcgtgag gtgtataact ttgcgttcct gttagtgtta       60

cgccgtgagg tttatgacaa ggacgagttg ttactgctgt tagaagatcg ccaactgttg      120

cgtcgtgaag ttttctgtgg ctttcgtgat ctgttagaag accgcgtcta tgacttcgcc      180

tttagtgatt tgaagctgcc acaattgtgt acggaactga aactgcctca actgtgtaca      240

gaactgaagg atgagctgaa agatgaatta gtgctgttat tgctcgag                   288


<210>  15
<211>  150
<212>  DNA
<213>  Artificial sequence

<220>
<223>  E701 DNA sequence

<400>  15
gaattcgtcg accaggcgga accagatcaa gcggaacctg accgtgcccg cgcacattat       60

aacattcgcg cacgtgcaca ctataatctg gaggcgcatt ataacattgt catcttccgc      120

gcacattata acatcgtcat tttcctcgag                                       150


<210>  16
<211>  207
<212>  DNA
<213>  Artificial sequence

<220>
<223>  E713 DNA sequence

<400>  16
gaattcgtcg accaggcgga accagatcaa gcggaacctg accgtgacga gctggtgtta       60

cgcgcccgcg cacattataa cattcgcgca cgtgcacact ataatctgga ggatcgttta      120

ctggtcttgc gtgcgcatta taacattgtc atcttccgcg cacattataa catcgtcatt      180

ttcaaagatg agttgctggt tctcgag                                          207


<210>  17
<211>  72
<212>  PRT
<213>  Artificial sequence

<220>
<223>  fused peptide

<400>  17

Glu Phe Val Asp Val Phe Leu Gln Lys Tyr Pro His Thr His Leu Val 
1               5                   10                  15      


His Gln Ala Leu Asp Val Phe Leu Gln Lys Tyr Pro His Thr His Leu 
            20                  25                  30          


Val His Gln Ala Leu Asp Val Phe Leu Gln Lys Tyr Pro His Thr His 
        35                  40                  45              


Leu Val His Gln Ala Leu Asp Val Phe Leu Gln Lys Tyr Pro His Thr 
    50                  55                  60                  


His Leu Val His Gln Ala Leu Glu 
65                  70          


<210>  18
<211>  277
<212>  PRT
<213>  Artificial sequence

<220>
<223>  fused peptide

<400>  18

Glu Phe Leu Leu Glu Pro His Thr His Leu Val His Gln Ala Asn Val 
1               5                   10                  15      


Leu Leu Ala Leu Gln Leu Leu Leu Glu Asp Arg Glu Phe Val Phe Leu 
            20                  25                  30          


Gln Lys Tyr Pro His Val Glu Pro His Thr His Leu Val His Gln Ala 
        35                  40                  45              


Asn Val Leu Leu Ala Leu Gln Leu Leu Leu Glu Asp Arg Glu Phe Val 
    50                  55                  60                  


Phe Leu Gln Lys Tyr Pro His Val Glu Pro His Thr His Leu Val His 
65                  70                  75                  80  


Gln Ala Asn Val Leu Leu Ala Leu Gln Leu Leu Leu Glu Asp Arg Glu 
                85                  90                  95      


Phe Val Phe Leu Gln Lys Tyr Pro His Val Glu Pro His Thr His Leu 
            100                 105                 110         


Val His Gln Ala Asn Val Leu Leu Ala Leu Gln Leu Leu Leu Glu Asp 
        115                 120                 125             


Arg Glu Phe Val Phe Leu Gln Lys Tyr Pro His Val Glu Pro His Thr 
    130                 135                 140                 


His Leu Val His Gln Ala Asn Val Leu Leu Ala Leu Gln Leu Leu Leu 
145                 150                 155                 160 


Glu Asp Arg Glu Phe Val Phe Leu Gln Lys Tyr Pro His Val Glu Pro 
                165                 170                 175     


His Thr His Leu Val His Gln Ala Asn Val Leu Leu Ala Leu Gln Leu 
            180                 185                 190         


Leu Leu Glu Asp Arg Glu Phe Val Phe Leu Gln Lys Tyr Pro His Val 
        195                 200                 205             


Glu Pro His Thr His Leu Val His Gln Ala Asn Val Leu Leu Ala Leu 
    210                 215                 220                 


Gln Leu Leu Leu Glu Asp Arg Glu Phe Val Phe Leu Gln Lys Tyr Pro 
225                 230                 235                 240 


His Val Glu Pro His Thr His Leu Val His Gln Ala Asn Val Leu Leu 
                245                 250                 255     


Ala Leu Gln Leu Leu Leu Glu Asp Arg Glu Phe Val Phe Leu Gln Lys 
            260                 265                 270         


Tyr Pro His Val Asp 
        275         


<210>  19
<211>  216
<212>  DNA
<213>  Artificial sequence

<220>
<223>  M14 DNA sequence

<400>  19
gaattcgtcg acgtgttttt acaaaaatat cctcatacgc acctggtcca tcaggcgctc       60

gacgtgtttt tacaaaaata tcctcatacg cacctggtcc atcaggcgct cgacgtgttt      120

ttacaaaaat atcctcatac gcacctggtc catcaggcgc tcgacgtgtt tttacaaaaa      180

tatcctcata cgcacctggt ccatcaggcg ctcgag                                216


<210>  20
<211>  831
<212>  DNA
<213>  Artificial sequence

<220>
<223>  M27 DNA sequence

<400>  20
gaattcctcc tcgagccaca tacgcactta gtgcatcaag cgaacgtttt gctggcactg       60

caattattat tagaagatcg tgaatttgtc ttcttgcaaa aatatccaca cgtcgagcca      120

catacgcact tagtgcatca agcgaacgtt ttgctggcac tgcaattatt attagaagat      180

cgtgaatttg tcttcttgca aaaatatcca cacgtcgagc cacatacgca cttagtgcat      240

caagcgaacg ttttgctggc actgcaatta ttattagaag atcgtgaatt tgtcttcttg      300

caaaaatatc cacacgtcga gccacatacg cacttagtgc atcaagcgaa cgttttgctg      360

gcactgcaat tattattaga agatcgtgaa tttgtcttct tgcaaaaata tccacacgtc      420

gagccacata cgcacttagt gcatcaagcg aacgttttgc tggcactgca attattatta      480

gaagatcgtg aatttgtctt cttgcaaaaa tatccacacg tcgagccaca tacgcactta      540

gtgcatcaag cgaacgtttt gctggcactg caattattat tagaagatcg tgaatttgtc      600

ttcttgcaaa aatatccaca cgtcgagcca catacgcact tagtgcatca agcgaacgtt      660

ttgctggcac tgcaattatt attagaagat cgtgaatttg tcttcttgca aaaatatcca      720

cacgtcgagc cacatacgca cttagtgcat caagcgaacg ttttgctggc actgcaatta      780

ttattagaag atcgtgaatt tgtcttcttg caaaaatatc cacacgtcga c               831


<210>  21
<211>  297
<212>  PRT
<213>  Porcine reproductive and respiratory syndrome virus

<400>  21

Glu Phe Val Ser Phe Ser Thr Gly Gly Ser Gln Asn Trp Thr Val Glu 
1               5                   10                  15      


Arg Leu Leu Gln Ala Glu Phe Cys Ser Thr Ser Gln Ala Ala Arg Gln 
            20                  25                  30          


Arg Leu Glu Thr Gly Arg Asn Cys Ser Thr Gly Gln Ala Ala Arg Gln 
        35                  40                  45              


Arg Leu Glu Pro Gly Arg Asn Leu Val Leu Cys Leu Thr Ser Gln Ala 
    50                  55                  60                  


Ala Gln Gln Arg Leu Glu Pro Gly Gly Asn Cys Gln Thr Ser Gln Ala 
65                  70                  75                  80  


Ala His Gln Arg Leu Glu Pro Gly Arg Asn Cys Arg Thr Ser Gln Ala 
                85                  90                  95      


Ala Ser Gln Arg Leu Glu Pro Gly Arg Asn Cys Arg Thr Ser Gln Ala 
            100                 105                 110         


Ala His Gln Arg Leu Glu Pro Gly Arg Asn Cys Ser Thr Arg Gln Ala 
        115                 120                 125             


Ala Gln Gln Arg Leu Glu Pro Gly Arg Asn Leu Leu Cys Pro Thr Ser 
    130                 135                 140                 


Gln Ala Ala His Gln Arg Arg Leu Glu Pro Gly Arg Asn Cys Ser Thr 
145                 150                 155                 160 


Ser Gln Ala Ala Tyr Gln Arg Leu Glu Pro Gly Arg Asn Cys Pro Thr 
                165                 170                 175     


Ser Arg Ala Ala Arg Gln Arg Leu Glu Pro Gly Arg Asn Leu Leu Cys 
            180                 185                 190         


Ser Thr Ser Gln Ala Ala Leu Gln Arg Leu Glu Pro Gly Arg Asn Leu 
        195                 200                 205             


Cys Pro Thr Ser Gln Ala Ala Lys Gln Arg Leu Glu Pro Gly Arg Asn 
    210                 215                 220                 


Leu Val Val Cys Leu Thr Ser Gln Ala Ala Arg Gln Arg Leu Glu Pro 
225                 230                 235                 240 


Gly Arg Asn Cys Ser Thr Ser Gln Ala Ala Ser Gln Arg Leu Glu Pro 
                245                 250                 255     


Gly Arg Asn Cys Pro Thr Ser Gln Ala Ala Arg Gln Arg Leu Glu Pro 
            260                 265                 270         


Gly Arg Asn Val Leu Leu Leu Cys Leu Thr Ser Gln Ala Ala His Gln 
        275                 280                 285             


Arg Leu Glu Pro Gly Arg Asn Leu Glu 
    290                 295         


<210>  22
<211>  230
<212>  PRT
<213>  Porcine reproductive and respiratory syndrome virus

<400>  22

Glu Phe Gly Val Ser Ala Ala Gln Glu Lys Ile Ser Phe Gly Leu Leu 
1               5                   10                  15      


Gly Val Pro Thr Ala Gln Glu Thr Thr Ser Ile Arg Glu Val Leu Glu 
            20                  25                  30          


Val Ser Thr Ala Gln Glu Asn Ser Pro Phe Met Leu Gly Ala Ser Ala 
        35                  40                  45              


Thr Glu Glu Lys Thr Ser Leu Arg Leu Gly Ala Ser Thr Thr Gln Glu 
    50                  55                  60                  


Thr Ser Phe Gly Lys Cys Leu Arg Pro His Gly Val Ser Ala Ala Gln 
65                  70                  75                  80  


Gly Thr Thr Pro Phe Arg Gly Val Ser Thr Thr Gln Glu Asn Thr Ser 
                85                  90                  95      


Phe Gly Arg Val Pro Thr Ala Gln Glu Asn Val Ser Phe Gly Leu His 
            100                 105                 110         


Gly Val Pro Ala Ala Gln Lys Thr Asn Ser Phe Gly Gly Val Pro Thr 
        115                 120                 125             


Ala Gln Glu Asn Ile Ser Phe Lys Glu Val Ser Ala Thr Gln Arg Glu 
    130                 135                 140                 


Ile Pro Phe Arg Cys Leu Arg Pro His Gly Val Ser Thr Ala Gln Glu 
145                 150                 155                 160 


Thr Pro Phe Arg Gly Val Ser Thr Ala Gln Glu Thr Ile Pro Phe Arg 
                165                 170                 175     


Gly Val Ser Ala Thr His Glu Asn Ile Ser Phe Gly Cys Leu Arg Pro 
            180                 185                 190         


His Gly Val Ser Ala Ala Gln Glu Ser Ile Pro Ile Arg Leu Gly Ala 
        195                 200                 205             


Ser Ala Ala Gln Glu Asn Thr Ser Phe Arg Gly Thr Pro Ala Ala Gln 
    210                 215                 220                 


Glu Lys Ile Pro Leu Glu 
225                 230 


<210>  23
<211>  289
<212>  PRT
<213>  Porcine reproductive and respiratory syndrome virus

<400>  23

Glu Phe Leu Gly Val Ser Ala Ala Gln Glu Arg Ile Pro Ile Arg Glu 
1               5                   10                  15      


Val Ser Ala Asp Lys Glu Val Ser Ala Glu Lys Lys Glu Ile Ser Phe 
            20                  25                  30          


Gly Val Ser Thr Ala Gln Gly Asn Ile Ser Phe Gly Leu Gly Val Ser 
        35                  40                  45              


Thr Ala Gln Glu Ala Ile Pro Phe Leu Ala Leu Gly Val Ser Thr Ala 
    50                  55                  60                  


Gln Glu Thr Ile Pro Phe Gly Leu Leu Gly Val Ser Thr Ala Gln Gly 
65                  70                  75                  80  


Ile Ile Ser Phe Gly Gly Val Ser Thr Ala Gln Glu Asn Ile Ser Phe 
                85                  90                  95      


Gly Gly Val Ser Thr Ala Gln Glu Thr Ile Ser Phe Gly Leu Leu Gly 
            100                 105                 110         


Val Ser Thr Ala Gln Glu Asn Ile Ser Phe Gly Cys Leu Arg Thr His 
        115                 120                 125             


Glu Val Ser Ala Ala Gln Glu Lys Ile Ser Phe Gly Gly Val Ser Glu 
    130                 135                 140                 


Ala Gln Lys Ile Ser Phe Gly Val Ser Ala Ala Gly Val Ser Ala Ala 
145                 150                 155                 160 


Gln Glu Glu Ile Pro Phe Gly Cys Leu Arg Pro His Gly Leu Pro Ala 
                165                 170                 175     


Ala Gln Glu Lys Thr Ser Phe Gly Gly Val Ser Ala Ala Gln Glu Lys 
            180                 185                 190         


Thr Ser Phe Gly Gly Val Ser Ala Ala Gln Glu Glu Phe Ser Phe Gly 
        195                 200                 205             


Cys Leu Arg Pro His Arg Val Ser Ala Ala Gln Glu Lys Ile Ser Phe 
    210                 215                 220                 


Glu Val Ser Ala Leu Glu Val Ser Ala Ala Gln Glu Lys Ile Ser Phe 
225                 230                 235                 240 


Gly Val Ser Ala Ala Leu Gly Val Ser Ala Ala Gln Glu Lys Asn Ser 
                245                 250                 255     


Phe Gly Cys Leu Arg Pro His Gly Val Ser Ala Ala Gln Glu Lys Thr 
            260                 265                 270         


Ser Phe Gly Gly Val Ser Ala Ala Gln Lys Lys Ile Ser Phe Gly Leu 
        275                 280                 285             


Glu 
    


<210>  24
<211>  892
<212>  DNA
<213>  Porcine reproductive and respiratory syndrome virus

<400>  24
ggaattcgtg agctttagca cgggtggcag ccagaactgg acggtggaac gtctgctgca       60

agccgagttc tgtagtactt ctcaggcggc gcgccagcgt ctggaaccag ggcgtaattg      120

ttctacaggc caggccgcac gtcaacgttt agagccaggt cgcaatttag ttttgtgtct      180

gacgagccag gccgcacagc agcgcttgga accaggcggt aactgtcaaa cttctcaagc      240

ggcccatcaa cgcctggaac caggtcgcaa ctgtcgcact agccaagccg ccagccaacg      300

tttagagcca ggccgcaact gtcgcacgag tcaggcggcg caccaacgtc tggaaccagg      360

ccgtaattgt agtacgcgcc aagcagccca gcaacgctta gaaccagggc gcaacctgtt      420

atgtccaact tctcaggcgg cccatcaacg ccgcttagaa ccagggcgta attgtagcac      480

gtctcaagca gcatatcaac gtctggaacc aggccgcaac tgtccaactt ctcgtgcggc      540

acgccagcgc ttagaaccag gtcgtaattt attatgttct actagccaag ccgcattaca      600

gcgtttagag ccagggcgta acctgtgtcc aactagccaa gcagcaaaac aacgcctgga      660

gccaggtcgt aatttagtgg tctgtttaac gagccaagcg gcgcgtcaac gcttagaacc      720

aggtcgcaat tgttctacta gccaagcggc cagtcaacgt ttagaaccag ggcgcaactg      780

tccaacgagc caagcggcgc gccaacgttt agagccaggg cgcaacgttt tattgttgtg      840

tctgacgagt caagccgccc atcaacgtct ggaaccaggt cgcaatctcg ag              892


<210>  25
<211>  696
<212>  DNA
<213>  Porcine reproductive and respiratory syndrome virus

<400>  25
gaattcggcg tgagcgcggc ccaggaaaag atcagtttcg gcctgttagg tgtgccaacg       60

gcccaagaga ctacaagtat tcgcgaggtt ttggaagtca gtactgcaca agaaaacagt      120

ccatttatgt taggcgcgag tgccacggag gaaaaaacgt ctttgcgcct gggggcaagc      180

acaacgcagg agacgagttt tggcaagtgt ttacgtccac atggggtttc tgcagcccaa      240

gggacgactc catttcgcgg tgtcagtaca acgcaagaaa acacgagttt tggtcgtgtc      300

ccaacggcac aagagaacgt gtcttttggc ctgcatggtg ttccagcagc gcaaaagacg      360

aacagcttcg gtggcgttcc aacggcacaa gaaaacatta gttttaagga ggttagtgcc      420

acgcaacgtg aaatcccatt ccgttgttta cgcccacacg gggttagcac agcccaggag      480

actccatttc gcggggtgag tactgcccag gagacgatcc cattccgtgg ggtttctgca      540

acgcatgaaa acatcagttt tgggtgtttg cgtccacatg gtgtcagcgc cgcacaggaa      600

tctattccaa tccgtctggg cgcgagcgca gcccaagaga ataccagttt tcgcgggaca      660

ccagcggcac aggagaaaat cccattggaa ctcgag                                696


<210>  26
<211>  870
<212>  DNA
<213>  Porcine reproductive and respiratory syndrome virus

<400>  26
gaattcctgg gcgtgagcgc agcccaagag cgcatcccaa ttcgcgaggt gagcgccgac       60

aaagaggtga gtgccgagaa gaaagagatc tctttcgggg tgagcaccgc gcagggtaat      120

atcagttttg gtttgggcgt cagcaccgca caggaggcaa ttccattctt ggcactgggg      180

gtcagtaccg cccaggaaac tattccattt ggcttgctgg gggttagcac tgcacaaggt      240

atcattagtt tcggcggggt ctctactgcg caggagaata tcagctttgg cggggttagt      300

actgcgcaag agaccattag ttttggtttg ctgggcgttt ctaccgccca ggagaatatt      360

agctttggtt gtttacgcac tcatgaagtt agtgccgcac aagagaaaat tagcttcggc      420

ggcgttagtg aagcgcaaga gaagattagt ttcggggtct ctgcagcagg cgtcagcgcc      480

gcccaagagg agattccatt tgggtgtctg cgcccacacg gcctgccagc ggcgcaggag      540

aaaaccagct tcggcggcgt tagtgccgcc caggaaaaga cctctttcgg tggtgtcagc      600

gcagcacaag aagagttctc ttttggttgt ttgcgcccac atcgtgttag tgccgcacag      660

gaaaagatca gctttgaagt tagcgcgctg gaagtcagtg ccgcgcaaga gaagattagt      720

tttggcgtta gcgcggcatt gggtgtcagc gcagcacaag aaaagaactc tttcggttgt      780

ttacgcccac acggtgttag cgccgcgcaa gagaaaacca gcttcggggg tgttagtgcc      840

gcacaaaaaa agatcagctt tgggctcgag                                       870


<210>  27
<211>  359
<212>  DNA
<213>  Artificial sequence

<220>
<223>  partial sequence of plasmid

<400>  27
gtttaacttt aagaaggaga tataccatgg ccgaacaatt ggtggacctc tggaacgaat       60

gcgccaaagc ctgcgtgctc gacctcaagg acggcgtgcg ttccagccgc atgagcgtcg      120

acccggccat cgccgacacc aacggccagg gcgtgctgca ctactgcatg gaattctctt      180

ttcatcagct gccagcgcgt tctccagccc cactgcagct cgagcatatg gccgaagaag      240

ctttcgacct ctggaacgaa tgcgccaaag cctgcgtgct cgacctcaag gacggcgtgc      300

gttccagccg catgagcgtc gagcaccacc accaccacca ctgagatccg gctgctaac       359


<210>  28
<211>  383
<212>  DNA
<213>  Artificial sequence

<220>
<223>  partial sequence of plasmid

<400>  28
gtttaacttt aagaaggaga tataccatgg ccgaacaatt ggtggacctc tggaacgaat       60

gcgccaaagc ctgcgtgctc gacctcaagg acggcgtgcg ttccagccgc atgagcgtcg      120

acccggccat cgccgacacc aacggccagg gcgtgctgca ctactgcatg gaattcagca      180

gctttcatct gttccaccat ctgccagcgc gtgcgccatt agcgccttct gaattacagc      240

ccctcgagca tatggccgaa gaagctttcg acctctggaa cgaatgcgcc aaagcctgcg      300

tgctcgacct caaggacggc gtgcgttcca gccgcatgag cgtcgagcac caccaccacc      360

accactgaga tccggctgct aac                                              383


<210>  29
<211>  368
<212>  DNA
<213>  Artificial sequence

<220>
<223>  partial sequence of plasmid

<400>  29
gtttaacttt aagaaggaga tataccatgg ccgaacaatt ggtggacctc tggaacgaat       60

gcgccaaagc ctgcgtgctc gacctcaagg acggcgtgcg ttccagccgc atgagcgtcg      120

acccggccat cgccgacacc aacggccagg gcgtgctgca ctactgcatg gaattctcta      180

ctcctttcca cccattgcct gcccgcaaac cattgcctct ggtgcccctc gagcatatgg      240

ccgaagaagc tttcgacctc tggaacgaat gcgccaaagc ctgcgtgctc gacctcaagg      300

acggcgtgcg ttccagccgc atgagcgtcg agcaccacca ccaccaccac tgagatccgg      360

ctgctaac                                                               368


<210>  30
<211>  941
<212>  DNA
<213>  Artificial sequence

<220>
<223>  partial sequence of plasmid

<400>  30
gtttaacttt aagaaggaga tataccatgg ccgaacaatt ggtggacctc tggaacgaat       60

gcgccaaagc ctgcgtgctc gacctcaagg acggcgtgcg ttccagccgc atgagcgtcg      120

acccggccat cgccgacacc aacggccagg gcgtgctgca ctactgcatg gaattccata      180

tggtcgacgg tatgtccatc cgtgctaaac gtcgtaaacg tgcttccgct acccagctgt      240

acaaaacctg caaacaggct ggtacctgcc cgccggacat catcccgaaa gttgaaggta      300

aaaccatcgc tgaacagatc ctgcaatacg gttctatggg tgttttcttc ggcggtctgg      360

gcatcggtac cggttccggt actggcggtc gtaccggtta catcccgctg ggtacccgtc      420

cgccgaccgc taccgacacc ctggctccgg ttcgtccgcc gctgaccgtt gacccggttg      480

gtccgtccga cccgtccatc gtttccctgg ttgaagaaac ctccttcatc gacgctggtg      540

ctccgacctc cgttccgtcc atcccgccgg acgtttccgg tttctccatc accacctcca      600

ccgacactac cccggctatc ctggacatca acaacaacac cgttactacc gtaaccactc      660

acaacaaccc gaccttcacc gacccgtccg ttctgcaacc gccgaccccg gctgaaaccg      720

gtggtcactt caccctgtcc tcttccacca tctccaccca caactacgaa gaaatcccga      780

tggacaccaa agacgaactg ctcgagcata tggccgaaga agctttcgac ctctggaacg      840

aatgcgccaa agcctgcgtg ctcgacctca aggacggcgt gcgttccagc cgcatgagcg      900

tcgagcacca ccaccaccac cactgagatc cggctgctaa c                          941


<210>  31
<211>  501
<212>  PRT
<213>  Artificial sequence

<220>
<223>  chimeric antigen

<400>  31

Met Gly Ser Ser His His His His His His Ser Ser Gly Leu Val Pro 
1               5                   10                  15      


Arg Gly Ser His Met Ala Glu Glu Ala Phe Asp Leu Trp Asn Glu Cys 
            20                  25                  30          


Ala Lys Ala Cys Val Leu Asp Leu Lys Asp Gly Val Arg Ser Ser Arg 
        35                  40                  45              


Met Ser Val Asp Pro Ala Ile Ala Asp Thr Asn Gly Gln Gly Val Leu 
    50                  55                  60                  


His Tyr Ser Met Val Leu Glu Gly Gly Asn Asp Ala Leu Lys Leu Ala 
65                  70                  75                  80  


Ile Asp Asn Ala Leu Ser Ile Thr Ser Asp Gly Leu Thr Ile Arg Leu 
                85                  90                  95      


Glu Gly Gly Val Glu Pro Asn Lys Pro Val Arg Tyr Ser Tyr Thr Arg 
            100                 105                 110         


Gln Ala Arg Gly Ser Trp Ser Leu Asn Trp Leu Val Pro Ile Gly His 
        115                 120                 125             


Glu Lys Pro Ser Asn Ile Lys Val Phe Ile His Glu Leu Asn Ala Gly 
    130                 135                 140                 


Asn Gln Leu Ser His Met Ser Pro Ile Tyr Thr Ile Glu Met Gly Asp 
145                 150                 155                 160 


Glu Leu Leu Ala Lys Leu Ala Arg Asp Ala Thr Phe Phe Val Arg Ala 
                165                 170                 175     


His Glu Ser Asn Glu Met Gln Pro Thr Leu Ala Ile Ser His Ala Gly 
            180                 185                 190         


Val Ser Val Val Met Ala Gln Thr Gln Pro Arg Arg Glu Lys Arg Trp 
        195                 200                 205             


Ser Glu Trp Ala Ser Gly Lys Val Leu Cys Leu Leu Asp Pro Leu Asp 
    210                 215                 220                 


Gly Val Tyr Asn Tyr Leu Ala Gln Gln Arg Cys Asn Leu Asp Asp Thr 
225                 230                 235                 240 


Trp Glu Gly Lys Ile Tyr Arg Val Leu Ala Gly Asn Pro Ala Lys His 
                245                 250                 255     


Asp Leu Asp Ile Lys Pro Thr Val Ile Ser His Arg Leu His Phe Pro 
            260                 265                 270         


Glu Gly Gly Ser Leu Ala Ala Leu Thr Ala His Gln Ala Cys His Leu 
        275                 280                 285             


Pro Leu Glu Thr Phe Thr Arg His Arg Gln Pro Arg Gly Trp Glu Gln 
    290                 295                 300                 


Leu Glu Gln Cys Gly Tyr Pro Val Gln Arg Leu Val Ala Leu Tyr Leu 
305                 310                 315                 320 


Ala Ala Arg Leu Ser Trp Asn Gln Val Asp Gln Val Ile Arg Asn Ala 
                325                 330                 335     


Leu Ala Ser Pro Gly Ser Gly Gly Asp Leu Gly Glu Ala Ile Arg Glu 
            340                 345                 350         


Gln Pro Glu Gln Ala Arg Leu Ala Leu Thr Leu Ala Ala Ala Glu Ser 
        355                 360                 365             


Glu Arg Phe Val Arg Gln Gly Thr Gly Asn Asp Glu Ala Gly Ala Ala 
    370                 375                 380                 


Asn Ala Asp Val Val Ser Leu Thr Cys Pro Val Ala Ala Gly Glu Cys 
385                 390                 395                 400 


Ala Gly Pro Ala Asp Ser Gly Asp Ala Leu Leu Glu Arg Asn Tyr Pro 
                405                 410                 415     


Thr Gly Ala Glu Phe Leu Gly Asp Gly Gly Asp Val Ser Phe Ser Thr 
            420                 425                 430         


Arg Gly Thr Gln Asn Trp Thr Val Glu Arg Leu Leu Gln Ala Glu Phe 
        435                 440                 445             


Gln Leu Leu Arg Arg Glu Val Phe Cys Gly Phe Arg Asp Leu Val Tyr 
    450                 455                 460                 


Asp Phe Ala Phe Ser Asp Leu Lys Leu Pro Gln Leu Cys Thr Glu Leu 
465                 470                 475                 480 


Lys Leu Pro Gln Leu Cys Thr Glu Leu Lys Asp Glu Leu Leu Glu His 
                485                 490                 495     


His His His His His 
            500     


<210>  32
<211>  500
<212>  PRT
<213>  Artificial sequence

<220>
<223>  chimeric antigen

<400>  32

Met Gly Ser Ser His His His His His His Ser Ser Gly Leu Val Pro 
1               5                   10                  15      


Arg Gly Ser His Met Ala Glu Glu Ala Phe Asp Leu Trp Asn Glu Cys 
            20                  25                  30          


Ala Lys Ala Cys Val Leu Asp Leu Lys Asp Gly Val Arg Ser Ser Arg 
        35                  40                  45              


Met Ser Val Asp Pro Ala Ile Ala Asp Thr Asn Gly Gln Gly Val Leu 
    50                  55                  60                  


His Tyr Ser Met Val Leu Glu Gly Gly Asn Asp Ala Leu Lys Leu Ala 
65                  70                  75                  80  


Ile Asp Asn Ala Leu Ser Ile Thr Ser Asp Gly Leu Thr Ile Arg Leu 
                85                  90                  95      


Glu Gly Gly Val Glu Pro Asn Lys Pro Val Arg Tyr Ser Tyr Thr Arg 
            100                 105                 110         


Gln Ala Arg Gly Ser Trp Ser Leu Asn Trp Leu Val Pro Ile Gly His 
        115                 120                 125             


Glu Lys Pro Ser Asn Ile Lys Val Phe Ile His Glu Leu Asn Ala Gly 
    130                 135                 140                 


Asn Gln Leu Ser His Met Ser Pro Ile Tyr Thr Ile Glu Met Gly Asp 
145                 150                 155                 160 


Glu Leu Leu Ala Lys Leu Ala Arg Asp Ala Thr Phe Phe Val Arg Ala 
                165                 170                 175     


His Glu Ser Asn Glu Met Gln Pro Thr Leu Ala Ile Ser His Ala Gly 
            180                 185                 190         


Val Ser Val Val Met Ala Gln Thr Gln Pro Arg Arg Glu Lys Arg Trp 
        195                 200                 205             


Ser Glu Trp Ala Ser Gly Lys Val Leu Cys Leu Leu Asp Pro Leu Asp 
    210                 215                 220                 


Gly Val Tyr Asn Tyr Leu Ala Gln Gln Arg Cys Asn Leu Asp Asp Thr 
225                 230                 235                 240 


Trp Glu Gly Lys Ile Tyr Arg Val Leu Ala Gly Asn Pro Ala Lys His 
                245                 250                 255     


Asp Leu Asp Ile Lys Pro Thr Val Ile Ser His Arg Leu His Phe Pro 
            260                 265                 270         


Glu Gly Gly Ser Leu Ala Ala Leu Thr Ala His Gln Ala Cys His Leu 
        275                 280                 285             


Pro Leu Glu Thr Phe Thr Arg His Arg Gln Pro Arg Gly Trp Glu Gln 
    290                 295                 300                 


Leu Glu Gln Cys Gly Tyr Pro Val Gln Arg Leu Val Ala Leu Tyr Leu 
305                 310                 315                 320 


Ala Ala Arg Leu Ser Trp Asn Gln Val Asp Gln Val Ile Arg Asn Ala 
                325                 330                 335     


Leu Ala Ser Pro Gly Ser Gly Gly Asp Leu Gly Glu Ala Ile Arg Glu 
            340                 345                 350         


Gln Pro Glu Gln Ala Arg Leu Ala Leu Thr Leu Ala Ala Ala Glu Ser 
        355                 360                 365             


Glu Arg Phe Val Arg Gln Gly Thr Gly Asn Asp Glu Ala Gly Ala Ala 
    370                 375                 380                 


Asn Ala Asp Val Val Ser Leu Thr Cys Pro Val Ala Ala Gly Glu Cys 
385                 390                 395                 400 


Ala Gly Pro Ala Asp Ser Gly Asp Ala Leu Leu Glu Arg Asn Tyr Pro 
                405                 410                 415     


Thr Gly Ala Glu Phe Leu Gly Asp Gly Gly Asp Val Ser Phe Ser Thr 
            420                 425                 430         


Arg Gly Thr Gln Asn Trp Thr Val Glu Arg Leu Leu Gln Ala Glu Phe 
        435                 440                 445             


Gln Ala Glu Pro Asp Gln Ala Glu Pro Asp Arg Ala Arg Ala His Tyr 
    450                 455                 460                 


Asn Ile Arg Ala Arg Ala His Tyr Asn Leu Glu Ala His Tyr Asn Ile 
465                 470                 475                 480 


Val Ile Phe Arg Ala His Tyr Asn Ile Val Ile Phe Leu Glu His His 
                485                 490                 495     


His His His His 
            500 


<210>  33
<211>  504
<212>  PRT
<213>  Artificial sequence

<220>
<223>  chimeric antigen

<400>  33

Met Gly Ser Ser His His His His His His Ser Ser Gly Leu Val Pro 
1               5                   10                  15      


Arg Gly Ser His Met Ala Glu Glu Ala Phe Asp Leu Trp Asn Glu Cys 
            20                  25                  30          


Ala Lys Ala Cys Val Leu Asp Leu Lys Asp Gly Val Arg Ser Ser Arg 
        35                  40                  45              


Met Ser Val Asp Pro Ala Ile Ala Asp Thr Asn Gly Gln Gly Val Leu 
    50                  55                  60                  


His Tyr Ser Met Val Leu Glu Gly Gly Asn Asp Ala Leu Lys Leu Ala 
65                  70                  75                  80  


Ile Asp Asn Ala Leu Ser Ile Thr Ser Asp Gly Leu Thr Ile Arg Leu 
                85                  90                  95      


Glu Gly Gly Val Glu Pro Asn Lys Pro Val Arg Tyr Ser Tyr Thr Arg 
            100                 105                 110         


Gln Ala Arg Gly Ser Trp Ser Leu Asn Trp Leu Val Pro Ile Gly His 
        115                 120                 125             


Glu Lys Pro Ser Asn Ile Lys Val Phe Ile His Glu Leu Asn Ala Gly 
    130                 135                 140                 


Asn Gln Leu Ser His Met Ser Pro Ile Tyr Thr Ile Glu Met Gly Asp 
145                 150                 155                 160 


Glu Leu Leu Ala Lys Leu Ala Arg Asp Ala Thr Phe Phe Val Arg Ala 
                165                 170                 175     


His Glu Ser Asn Glu Met Gln Pro Thr Leu Ala Ile Ser His Ala Gly 
            180                 185                 190         


Val Ser Val Val Met Ala Gln Thr Gln Pro Arg Arg Glu Lys Arg Trp 
        195                 200                 205             


Ser Glu Trp Ala Ser Gly Lys Val Leu Cys Leu Leu Asp Pro Leu Asp 
    210                 215                 220                 


Gly Val Tyr Asn Tyr Leu Ala Gln Gln Arg Cys Asn Leu Asp Asp Thr 
225                 230                 235                 240 


Trp Glu Gly Lys Ile Tyr Arg Val Leu Ala Gly Asn Pro Ala Lys His 
                245                 250                 255     


Asp Leu Asp Ile Lys Pro Thr Val Ile Ser His Arg Leu His Phe Pro 
            260                 265                 270         


Glu Gly Gly Ser Leu Ala Ala Leu Thr Ala His Gln Ala Cys His Leu 
        275                 280                 285             


Pro Leu Glu Thr Phe Thr Arg His Arg Gln Pro Arg Gly Trp Glu Gln 
    290                 295                 300                 


Leu Glu Gln Cys Gly Tyr Pro Val Gln Arg Leu Val Ala Leu Tyr Leu 
305                 310                 315                 320 


Ala Ala Arg Leu Ser Trp Asn Gln Val Asp Gln Val Ile Arg Asn Ala 
                325                 330                 335     


Leu Ala Ser Pro Gly Ser Gly Gly Asp Leu Gly Glu Ala Ile Arg Glu 
            340                 345                 350         


Gln Pro Glu Gln Ala Arg Leu Ala Leu Thr Leu Ala Ala Ala Glu Ser 
        355                 360                 365             


Glu Arg Phe Val Arg Gln Gly Thr Gly Asn Asp Glu Ala Gly Ala Ala 
    370                 375                 380                 


Asn Ala Asp Val Val Ser Leu Thr Cys Pro Val Ala Ala Gly Glu Cys 
385                 390                 395                 400 


Ala Gly Pro Ala Asp Ser Gly Asp Ala Leu Leu Glu Arg Asn Tyr Pro 
                405                 410                 415     


Thr Gly Ala Glu Phe Leu Gly Asp Gly Gly Asp Val Glu Phe Val Phe 
            420                 425                 430         


Leu Gln Lys Tyr Pro His Thr His Leu Val His Gln Ala Leu Asp Val 
        435                 440                 445             


Phe Leu Gln Lys Tyr Pro His Thr His Leu Val His Gln Ala Leu Asp 
    450                 455                 460                 


Val Phe Leu Gln Lys Tyr Pro His Thr His Leu Val His Gln Ala Leu 
465                 470                 475                 480 


Asp Val Phe Leu Gln Lys Tyr Pro His Thr His Leu Val His Gln Ala 
                485                 490                 495     


Leu Glu His His His His His His 
            500                 


<210>  34
<211>  711
<212>  PRT
<213>  Artificial sequence

<220>
<223>  chimeric antigen

<400>  34

Met Gly Ser Ser His His His His His His Ser Ser Gly Leu Val Pro 
1               5                   10                  15      


Arg Gly Ser His Met Ala Glu Glu Ala Phe Asp Leu Trp Asn Glu Cys 
            20                  25                  30          


Ala Lys Ala Cys Val Leu Asp Leu Lys Asp Gly Val Arg Ser Ser Arg 
        35                  40                  45              


Met Ser Val Asp Pro Ala Ile Ala Asp Thr Asn Gly Gln Gly Val Leu 
    50                  55                  60                  


His Tyr Ser Met Val Leu Glu Gly Gly Asn Asp Ala Leu Lys Leu Ala 
65                  70                  75                  80  


Ile Asp Asn Ala Leu Ser Ile Thr Ser Asp Gly Leu Thr Ile Arg Leu 
                85                  90                  95      


Glu Gly Gly Val Glu Pro Asn Lys Pro Val Arg Tyr Ser Tyr Thr Arg 
            100                 105                 110         


Gln Ala Arg Gly Ser Trp Ser Leu Asn Trp Leu Val Pro Ile Gly His 
        115                 120                 125             


Glu Lys Pro Ser Asn Ile Lys Val Phe Ile His Glu Leu Asn Ala Gly 
    130                 135                 140                 


Asn Gln Leu Ser His Met Ser Pro Ile Tyr Thr Ile Glu Met Gly Asp 
145                 150                 155                 160 


Glu Leu Leu Ala Lys Leu Ala Arg Asp Ala Thr Phe Phe Val Arg Ala 
                165                 170                 175     


His Glu Ser Asn Glu Met Gln Pro Thr Leu Ala Ile Ser His Ala Gly 
            180                 185                 190         


Val Ser Val Val Met Ala Gln Thr Gln Pro Arg Arg Glu Lys Arg Trp 
        195                 200                 205             


Ser Glu Trp Ala Ser Gly Lys Val Leu Cys Leu Leu Asp Pro Leu Asp 
    210                 215                 220                 


Gly Val Tyr Asn Tyr Leu Ala Gln Gln Arg Cys Asn Leu Asp Asp Thr 
225                 230                 235                 240 


Trp Glu Gly Lys Ile Tyr Arg Val Leu Ala Gly Asn Pro Ala Lys His 
                245                 250                 255     


Asp Leu Asp Ile Lys Pro Thr Val Ile Ser His Arg Leu His Phe Pro 
            260                 265                 270         


Glu Gly Gly Ser Leu Ala Ala Leu Thr Ala His Gln Ala Cys His Leu 
        275                 280                 285             


Pro Leu Glu Thr Phe Thr Arg His Arg Gln Pro Arg Gly Trp Glu Gln 
    290                 295                 300                 


Leu Glu Gln Cys Gly Tyr Pro Val Gln Arg Leu Val Ala Leu Tyr Leu 
305                 310                 315                 320 


Ala Ala Arg Leu Ser Trp Asn Gln Val Asp Gln Val Ile Arg Asn Ala 
                325                 330                 335     


Leu Ala Ser Pro Gly Ser Gly Gly Asp Leu Gly Glu Ala Ile Arg Glu 
            340                 345                 350         


Gln Pro Glu Gln Ala Arg Leu Ala Leu Thr Leu Ala Ala Ala Glu Ser 
        355                 360                 365             


Glu Arg Phe Val Arg Gln Gly Thr Gly Asn Asp Glu Ala Gly Ala Ala 
    370                 375                 380                 


Asn Ala Asp Val Val Ser Leu Thr Cys Pro Val Ala Ala Gly Glu Cys 
385                 390                 395                 400 


Ala Gly Pro Ala Asp Ser Gly Asp Ala Leu Leu Glu Arg Asn Tyr Pro 
                405                 410                 415     


Thr Gly Ala Glu Phe Leu Gly Asp Gly Gly Asp Val Glu Phe Leu Leu 
            420                 425                 430         


Glu Pro His Thr His Leu Val His Gln Ala Asn Val Leu Leu Ala Leu 
        435                 440                 445             


Gln Leu Leu Leu Glu Asp Arg Glu Phe Val Phe Leu Gln Lys Tyr Pro 
    450                 455                 460                 


His Val Glu Pro His Thr His Leu Val His Gln Ala Asn Val Leu Leu 
465                 470                 475                 480 


Ala Leu Gln Leu Leu Leu Glu Asp Arg Glu Phe Val Phe Leu Gln Lys 
                485                 490                 495     


Tyr Pro His Val Glu Pro His Thr His Leu Val His Gln Ala Asn Val 
            500                 505                 510         


Leu Leu Ala Leu Gln Leu Leu Leu Glu Asp Arg Glu Phe Val Phe Leu 
        515                 520                 525             


Gln Lys Tyr Pro His Val Glu Pro His Thr His Leu Val His Gln Ala 
    530                 535                 540                 


Asn Val Leu Leu Ala Leu Gln Leu Leu Leu Glu Asp Arg Glu Phe Val 
545                 550                 555                 560 


Phe Leu Gln Lys Tyr Pro His Val Glu Pro His Thr His Leu Val His 
                565                 570                 575     


Gln Ala Asn Val Leu Leu Ala Leu Gln Leu Leu Leu Glu Asp Arg Glu 
            580                 585                 590         


Phe Val Phe Leu Gln Lys Tyr Pro His Val Glu Pro His Thr His Leu 
        595                 600                 605             


Val His Gln Ala Asn Val Leu Leu Ala Leu Gln Leu Leu Leu Glu Asp 
    610                 615                 620                 


Arg Glu Phe Val Phe Leu Gln Lys Tyr Pro His Val Glu Pro His Thr 
625                 630                 635                 640 


His Leu Val His Gln Ala Asn Val Leu Leu Ala Leu Gln Leu Leu Leu 
                645                 650                 655     


Glu Asp Arg Glu Phe Val Phe Leu Gln Lys Tyr Pro His Val Glu Pro 
            660                 665                 670         


His Thr His Leu Val His Gln Ala Asn Val Leu Leu Ala Leu Gln Leu 
        675                 680                 685             


Leu Leu Glu Asp Arg Glu Phe Val Phe Leu Gln Lys Tyr Pro His Val 
    690                 695                 700                 


Glu His His His His His His 
705                 710     


<210>  35
<211>  749
<212>  PRT
<213>  Artificial sequence

<220>
<223>  chimeric antigen

<400>  35

Met Gly Ser Ser His His His His His His Ser Ser Gly Leu Val Pro 
1               5                   10                  15      


Arg Gly Ser His Met Ala Glu Glu Ala Phe Asp Leu Trp Asn Glu Cys 
            20                  25                  30          


Ala Lys Ala Cys Val Leu Asp Leu Lys Asp Gly Val Arg Ser Ser Arg 
        35                  40                  45              


Met Ser Val Asp Pro Ala Ile Ala Asp Thr Asn Gly Gln Gly Val Leu 
    50                  55                  60                  


His Tyr Ser Met Val Leu Glu Gly Gly Asn Asp Ala Leu Lys Leu Ala 
65                  70                  75                  80  


Ile Asp Asn Ala Leu Ser Ile Thr Ser Asp Gly Leu Thr Ile Arg Leu 
                85                  90                  95      


Glu Gly Gly Val Glu Pro Asn Lys Pro Val Arg Tyr Ser Tyr Thr Arg 
            100                 105                 110         


Gln Ala Arg Gly Ser Trp Ser Leu Asn Trp Leu Val Pro Ile Gly His 
        115                 120                 125             


Glu Lys Pro Ser Asn Ile Lys Val Phe Ile His Glu Leu Asn Ala Gly 
    130                 135                 140                 


Asn Gln Leu Ser His Met Ser Pro Ile Tyr Thr Ile Glu Met Gly Asp 
145                 150                 155                 160 


Glu Leu Leu Ala Lys Leu Ala Arg Asp Ala Thr Phe Phe Val Arg Ala 
                165                 170                 175     


His Glu Ser Asn Glu Met Gln Pro Thr Leu Ala Ile Ser His Ala Gly 
            180                 185                 190         


Val Ser Val Val Met Ala Gln Thr Gln Pro Arg Arg Glu Lys Arg Trp 
        195                 200                 205             


Ser Glu Trp Ala Ser Gly Lys Val Leu Cys Leu Leu Asp Pro Leu Asp 
    210                 215                 220                 


Gly Val Tyr Asn Tyr Leu Ala Gln Gln Arg Cys Asn Leu Asp Asp Thr 
225                 230                 235                 240 


Trp Glu Gly Lys Ile Tyr Arg Val Leu Ala Gly Asn Pro Ala Lys His 
                245                 250                 255     


Asp Leu Asp Ile Lys Pro Thr Val Ile Ser His Arg Leu His Phe Pro 
            260                 265                 270         


Glu Gly Gly Ser Leu Ala Ala Leu Thr Ala His Gln Ala Cys His Leu 
        275                 280                 285             


Pro Leu Glu Thr Phe Thr Arg His Arg Gln Pro Arg Gly Trp Glu Gln 
    290                 295                 300                 


Leu Glu Gln Cys Gly Tyr Pro Val Gln Arg Leu Val Ala Leu Tyr Leu 
305                 310                 315                 320 


Ala Ala Arg Leu Ser Trp Asn Gln Val Asp Gln Val Ile Arg Asn Ala 
                325                 330                 335     


Leu Ala Ser Pro Gly Ser Gly Gly Asp Leu Gly Glu Ala Ile Arg Glu 
            340                 345                 350         


Gln Pro Glu Gln Ala Arg Leu Ala Leu Thr Leu Ala Ala Ala Glu Ser 
        355                 360                 365             


Glu Arg Phe Val Arg Gln Gly Thr Gly Asn Asp Glu Ala Gly Ala Ala 
    370                 375                 380                 


Asn Ala Asp Val Val Ser Leu Thr Cys Pro Val Ala Ala Gly Glu Cys 
385                 390                 395                 400 


Ala Gly Pro Ala Asp Ser Gly Asp Ala Leu Leu Glu Arg Asn Tyr Pro 
                405                 410                 415     


Thr Gly Ala Glu Phe Leu Gly Asp Gly Gly Asp Val Ser Phe Ser Thr 
            420                 425                 430         


Arg Gly Thr Gln Asn Trp Thr Val Glu Arg Leu Leu Gln Ala Glu Phe 
        435                 440                 445             


Val Ser Phe Ser Thr Gly Gly Ser Gln Asn Trp Thr Val Glu Arg Leu 
    450                 455                 460                 


Leu Gln Ala Glu Phe Cys Ser Thr Ser Gln Ala Ala Arg Gln Arg Leu 
465                 470                 475                 480 


Glu Thr Gly Arg Asn Cys Ser Thr Gly Gln Ala Ala Arg Gln Arg Leu 
                485                 490                 495     


Glu Pro Gly Arg Asn Leu Val Leu Cys Leu Thr Ser Gln Ala Ala Gln 
            500                 505                 510         


Gln Arg Leu Glu Pro Gly Gly Asn Cys Gln Thr Ser Gln Ala Ala His 
        515                 520                 525             


Gln Arg Leu Glu Pro Gly Arg Asn Cys Arg Thr Ser Gln Ala Ala Ser 
    530                 535                 540                 


Gln Arg Leu Glu Pro Gly Arg Asn Cys Arg Thr Ser Gln Ala Ala His 
545                 550                 555                 560 


Gln Arg Leu Glu Pro Gly Arg Asn Cys Ser Thr Arg Gln Ala Ala Gln 
                565                 570                 575     


Gln Arg Leu Glu Pro Gly Arg Asn Leu Leu Cys Pro Thr Ser Gln Ala 
            580                 585                 590         


Ala His Gln Arg Arg Leu Glu Pro Gly Arg Asn Cys Ser Thr Ser Gln 
        595                 600                 605             


Ala Ala Tyr Gln Arg Leu Glu Pro Gly Arg Asn Cys Pro Thr Ser Arg 
    610                 615                 620                 


Ala Ala Arg Gln Arg Leu Glu Pro Gly Arg Asn Leu Leu Cys Ser Thr 
625                 630                 635                 640 


Ser Gln Ala Ala Leu Gln Arg Leu Glu Pro Gly Arg Asn Leu Cys Pro 
                645                 650                 655     


Thr Ser Gln Ala Ala Lys Gln Arg Leu Glu Pro Gly Arg Asn Leu Val 
            660                 665                 670         


Val Cys Leu Thr Ser Gln Ala Ala Arg Gln Arg Leu Glu Pro Gly Arg 
        675                 680                 685             


Asn Cys Ser Thr Ser Gln Ala Ala Ser Gln Arg Leu Glu Pro Gly Arg 
    690                 695                 700                 


Asn Cys Pro Thr Ser Gln Ala Ala Arg Gln Arg Leu Glu Pro Gly Arg 
705                 710                 715                 720 


Asn Val Leu Leu Leu Cys Leu Thr Ser Gln Ala Ala His Gln Arg Leu 
                725                 730                 735     


Glu Pro Gly Arg Asn Leu Glu His His His His His His 
            740                 745                 


<210>  36
<211>  682
<212>  PRT
<213>  Artificial sequence

<220>
<223>  chimeric antigen

<400>  36

Met Gly Ser Ser His His His His His His Ser Ser Gly Leu Val Pro 
1               5                   10                  15      


Arg Gly Ser His Met Ala Glu Glu Ala Phe Asp Leu Trp Asn Glu Cys 
            20                  25                  30          


Ala Lys Ala Cys Val Leu Asp Leu Lys Asp Gly Val Arg Ser Ser Arg 
        35                  40                  45              


Met Ser Val Asp Pro Ala Ile Ala Asp Thr Asn Gly Gln Gly Val Leu 
    50                  55                  60                  


His Tyr Ser Met Val Leu Glu Gly Gly Asn Asp Ala Leu Lys Leu Ala 
65                  70                  75                  80  


Ile Asp Asn Ala Leu Ser Ile Thr Ser Asp Gly Leu Thr Ile Arg Leu 
                85                  90                  95      


Glu Gly Gly Val Glu Pro Asn Lys Pro Val Arg Tyr Ser Tyr Thr Arg 
            100                 105                 110         


Gln Ala Arg Gly Ser Trp Ser Leu Asn Trp Leu Val Pro Ile Gly His 
        115                 120                 125             


Glu Lys Pro Ser Asn Ile Lys Val Phe Ile His Glu Leu Asn Ala Gly 
    130                 135                 140                 


Asn Gln Leu Ser His Met Ser Pro Ile Tyr Thr Ile Glu Met Gly Asp 
145                 150                 155                 160 


Glu Leu Leu Ala Lys Leu Ala Arg Asp Ala Thr Phe Phe Val Arg Ala 
                165                 170                 175     


His Glu Ser Asn Glu Met Gln Pro Thr Leu Ala Ile Ser His Ala Gly 
            180                 185                 190         


Val Ser Val Val Met Ala Gln Thr Gln Pro Arg Arg Glu Lys Arg Trp 
        195                 200                 205             


Ser Glu Trp Ala Ser Gly Lys Val Leu Cys Leu Leu Asp Pro Leu Asp 
    210                 215                 220                 


Gly Val Tyr Asn Tyr Leu Ala Gln Gln Arg Cys Asn Leu Asp Asp Thr 
225                 230                 235                 240 


Trp Glu Gly Lys Ile Tyr Arg Val Leu Ala Gly Asn Pro Ala Lys His 
                245                 250                 255     


Asp Leu Asp Ile Lys Pro Thr Val Ile Ser His Arg Leu His Phe Pro 
            260                 265                 270         


Glu Gly Gly Ser Leu Ala Ala Leu Thr Ala His Gln Ala Cys His Leu 
        275                 280                 285             


Pro Leu Glu Thr Phe Thr Arg His Arg Gln Pro Arg Gly Trp Glu Gln 
    290                 295                 300                 


Leu Glu Gln Cys Gly Tyr Pro Val Gln Arg Leu Val Ala Leu Tyr Leu 
305                 310                 315                 320 


Ala Ala Arg Leu Ser Trp Asn Gln Val Asp Gln Val Ile Arg Asn Ala 
                325                 330                 335     


Leu Ala Ser Pro Gly Ser Gly Gly Asp Leu Gly Glu Ala Ile Arg Glu 
            340                 345                 350         


Gln Pro Glu Gln Ala Arg Leu Ala Leu Thr Leu Ala Ala Ala Glu Ser 
        355                 360                 365             


Glu Arg Phe Val Arg Gln Gly Thr Gly Asn Asp Glu Ala Gly Ala Ala 
    370                 375                 380                 


Asn Ala Asp Val Val Ser Leu Thr Cys Pro Val Ala Ala Gly Glu Cys 
385                 390                 395                 400 


Ala Gly Pro Ala Asp Ser Gly Asp Ala Leu Leu Glu Arg Asn Tyr Pro 
                405                 410                 415     


Thr Gly Ala Glu Phe Leu Gly Asp Gly Gly Asp Val Ser Phe Ser Thr 
            420                 425                 430         


Arg Gly Thr Gln Asn Trp Thr Val Glu Arg Leu Leu Gln Ala Glu Phe 
        435                 440                 445             


Gly Val Ser Ala Ala Gln Glu Lys Ile Ser Phe Gly Leu Leu Gly Val 
    450                 455                 460                 


Pro Thr Ala Gln Glu Thr Thr Ser Ile Arg Glu Val Leu Glu Val Ser 
465                 470                 475                 480 


Thr Ala Gln Glu Asn Ser Pro Phe Met Leu Gly Ala Ser Ala Thr Glu 
                485                 490                 495     


Glu Lys Thr Ser Leu Arg Leu Gly Ala Ser Thr Thr Gln Glu Thr Ser 
            500                 505                 510         


Phe Gly Lys Cys Leu Arg Pro His Gly Val Ser Ala Ala Gln Gly Thr 
        515                 520                 525             


Thr Pro Phe Arg Gly Val Ser Thr Thr Gln Glu Asn Thr Ser Phe Gly 
    530                 535                 540                 


Arg Val Pro Thr Ala Gln Glu Asn Val Ser Phe Gly Leu His Gly Val 
545                 550                 555                 560 


Pro Ala Ala Gln Lys Thr Asn Ser Phe Gly Gly Val Pro Thr Ala Gln 
                565                 570                 575     


Glu Asn Ile Ser Phe Lys Glu Val Ser Ala Thr Gln Arg Glu Ile Pro 
            580                 585                 590         


Phe Arg Cys Leu Arg Pro His Gly Val Ser Thr Ala Gln Glu Thr Pro 
        595                 600                 605             


Phe Arg Gly Val Ser Thr Ala Gln Glu Thr Ile Pro Phe Arg Gly Val 
    610                 615                 620                 


Ser Ala Thr His Glu Asn Ile Ser Phe Gly Cys Leu Arg Pro His Gly 
625                 630                 635                 640 


Val Ser Ala Ala Gln Glu Ser Ile Pro Ile Arg Leu Gly Ala Ser Ala 
                645                 650                 655     


Ala Gln Glu Asn Thr Ser Phe Arg Gly Thr Pro Ala Ala Gln Glu Lys 
            660                 665                 670         


Ile Pro Leu Glu His His His His His His 
        675                 680         


<210>  37
<211>  741
<212>  PRT
<213>  Artificial sequence

<220>
<223>  chimeric antigen

<400>  37

Met Gly Ser Ser His His His His His His Ser Ser Gly Leu Val Pro 
1               5                   10                  15      


Arg Gly Ser His Met Ala Glu Glu Ala Phe Asp Leu Trp Asn Glu Cys 
            20                  25                  30          


Ala Lys Ala Cys Val Leu Asp Leu Lys Asp Gly Val Arg Ser Ser Arg 
        35                  40                  45              


Met Ser Val Asp Pro Ala Ile Ala Asp Thr Asn Gly Gln Gly Val Leu 
    50                  55                  60                  


His Tyr Ser Met Val Leu Glu Gly Gly Asn Asp Ala Leu Lys Leu Ala 
65                  70                  75                  80  


Ile Asp Asn Ala Leu Ser Ile Thr Ser Asp Gly Leu Thr Ile Arg Leu 
                85                  90                  95      


Glu Gly Gly Val Glu Pro Asn Lys Pro Val Arg Tyr Ser Tyr Thr Arg 
            100                 105                 110         


Gln Ala Arg Gly Ser Trp Ser Leu Asn Trp Leu Val Pro Ile Gly His 
        115                 120                 125             


Glu Lys Pro Ser Asn Ile Lys Val Phe Ile His Glu Leu Asn Ala Gly 
    130                 135                 140                 


Asn Gln Leu Ser His Met Ser Pro Ile Tyr Thr Ile Glu Met Gly Asp 
145                 150                 155                 160 


Glu Leu Leu Ala Lys Leu Ala Arg Asp Ala Thr Phe Phe Val Arg Ala 
                165                 170                 175     


His Glu Ser Asn Glu Met Gln Pro Thr Leu Ala Ile Ser His Ala Gly 
            180                 185                 190         


Val Ser Val Val Met Ala Gln Thr Gln Pro Arg Arg Glu Lys Arg Trp 
        195                 200                 205             


Ser Glu Trp Ala Ser Gly Lys Val Leu Cys Leu Leu Asp Pro Leu Asp 
    210                 215                 220                 


Gly Val Tyr Asn Tyr Leu Ala Gln Gln Arg Cys Asn Leu Asp Asp Thr 
225                 230                 235                 240 


Trp Glu Gly Lys Ile Tyr Arg Val Leu Ala Gly Asn Pro Ala Lys His 
                245                 250                 255     


Asp Leu Asp Ile Lys Pro Thr Val Ile Ser His Arg Leu His Phe Pro 
            260                 265                 270         


Glu Gly Gly Ser Leu Ala Ala Leu Thr Ala His Gln Ala Cys His Leu 
        275                 280                 285             


Pro Leu Glu Thr Phe Thr Arg His Arg Gln Pro Arg Gly Trp Glu Gln 
    290                 295                 300                 


Leu Glu Gln Cys Gly Tyr Pro Val Gln Arg Leu Val Ala Leu Tyr Leu 
305                 310                 315                 320 


Ala Ala Arg Leu Ser Trp Asn Gln Val Asp Gln Val Ile Arg Asn Ala 
                325                 330                 335     


Leu Ala Ser Pro Gly Ser Gly Gly Asp Leu Gly Glu Ala Ile Arg Glu 
            340                 345                 350         


Gln Pro Glu Gln Ala Arg Leu Ala Leu Thr Leu Ala Ala Ala Glu Ser 
        355                 360                 365             


Glu Arg Phe Val Arg Gln Gly Thr Gly Asn Asp Glu Ala Gly Ala Ala 
    370                 375                 380                 


Asn Ala Asp Val Val Ser Leu Thr Cys Pro Val Ala Ala Gly Glu Cys 
385                 390                 395                 400 


Ala Gly Pro Ala Asp Ser Gly Asp Ala Leu Leu Glu Arg Asn Tyr Pro 
                405                 410                 415     


Thr Gly Ala Glu Phe Leu Gly Asp Gly Gly Asp Val Ser Phe Ser Thr 
            420                 425                 430         


Arg Gly Thr Gln Asn Trp Thr Val Glu Arg Leu Leu Gln Ala Glu Phe 
        435                 440                 445             


Leu Gly Val Ser Ala Ala Gln Glu Arg Ile Pro Ile Arg Glu Val Ser 
    450                 455                 460                 


Ala Asp Lys Glu Val Ser Ala Glu Lys Lys Glu Ile Ser Phe Gly Val 
465                 470                 475                 480 


Ser Thr Ala Gln Gly Asn Ile Ser Phe Gly Leu Gly Val Ser Thr Ala 
                485                 490                 495     


Gln Glu Ala Ile Pro Phe Leu Ala Leu Gly Val Ser Thr Ala Gln Glu 
            500                 505                 510         


Thr Ile Pro Phe Gly Leu Leu Gly Val Ser Thr Ala Gln Gly Ile Ile 
        515                 520                 525             


Ser Phe Gly Gly Val Ser Thr Ala Gln Glu Asn Ile Ser Phe Gly Gly 
    530                 535                 540                 


Val Ser Thr Ala Gln Glu Thr Ile Ser Phe Gly Leu Leu Gly Val Ser 
545                 550                 555                 560 


Thr Ala Gln Glu Asn Ile Ser Phe Gly Cys Leu Arg Thr His Glu Val 
                565                 570                 575     


Ser Ala Ala Gln Glu Lys Ile Ser Phe Gly Gly Val Ser Glu Ala Gln 
            580                 585                 590         


Lys Ile Ser Phe Gly Val Ser Ala Ala Gly Val Ser Ala Ala Gln Glu 
        595                 600                 605             


Glu Ile Pro Phe Gly Cys Leu Arg Pro His Gly Leu Pro Ala Ala Gln 
    610                 615                 620                 


Glu Lys Thr Ser Phe Gly Gly Val Ser Ala Ala Gln Glu Lys Thr Ser 
625                 630                 635                 640 


Phe Gly Gly Val Ser Ala Ala Gln Glu Glu Phe Ser Phe Gly Cys Leu 
                645                 650                 655     


Arg Pro His Arg Val Ser Ala Ala Gln Glu Lys Ile Ser Phe Glu Val 
            660                 665                 670         


Ser Ala Leu Glu Val Ser Ala Ala Gln Glu Lys Ile Ser Phe Gly Val 
        675                 680                 685             


Ser Ala Ala Leu Gly Val Ser Ala Ala Gln Glu Lys Asn Ser Phe Gly 
    690                 695                 700                 


Cys Leu Arg Pro His Gly Val Ser Ala Ala Gln Glu Lys Thr Ser Phe 
705                 710                 715                 720 


Gly Gly Val Ser Ala Ala Gln Lys Lys Ile Ser Phe Gly Leu Glu His 
                725                 730                 735     


His His His His His 
            740     


<210>  38
<211>  595
<212>  PRT
<213>  Artificial sequence

<220>
<223>  fusion biogenic polypeptide

<400>  38

Met Ala Glu Gln Leu Val Asp Leu Trp Asn Glu Cys Ala Lys Ala Cys 
1               5                   10                  15      


Val Leu Asp Leu Lys Asp Gly Val Arg Ser Ser Arg Met Ser Val Asp 
            20                  25                  30          


Pro Ala Ile Ala Asp Thr Asn Gly Gln Gly Val Leu His Tyr Cys Met 
        35                  40                  45              


Glu Phe Ser Phe His Gln Leu Pro Ala Arg Ser Pro Ala Pro Leu Gln 
    50                  55                  60                  


Leu Glu His Met Ala Glu Glu Ala Phe Asp Leu Trp Asn Glu Cys Ala 
65                  70                  75                  80  


Lys Ala Cys Val Leu Asp Leu Lys Asp Gly Val Arg Ser Ser Arg Met 
                85                  90                  95      


Ser Val Asp Pro Ala Ile Ala Asp Thr Asn Gly Gln Gly Val Leu His 
            100                 105                 110         


Tyr Ser Met Val Leu Glu Gly Gly Asn Asp Ala Leu Lys Leu Ala Ile 
        115                 120                 125             


Asp Asn Ala Leu Ser Ile Thr Ser Asp Gly Leu Thr Ile Arg Leu Glu 
    130                 135                 140                 


Gly Gly Val Glu Pro Asn Lys Pro Val Arg Tyr Ser Tyr Thr Arg Gln 
145                 150                 155                 160 


Ala Arg Gly Ser Trp Ser Leu Asn Trp Leu Val Pro Ile Gly His Glu 
                165                 170                 175     


Lys Pro Ser Asn Ile Lys Val Phe Ile His Glu Leu Asn Ala Gly Asn 
            180                 185                 190         


Gln Leu Ser His Met Ser Pro Ile Tyr Thr Ile Glu Met Gly Asp Glu 
        195                 200                 205             


Leu Leu Ala Lys Leu Ala Arg Asp Ala Thr Phe Phe Val Arg Ala His 
    210                 215                 220                 


Glu Ser Asn Glu Met Gln Pro Thr Leu Ala Ile Ser His Ala Gly Val 
225                 230                 235                 240 


Ser Val Val Met Ala Gln Thr Gln Pro Arg Arg Glu Lys Arg Trp Ser 
                245                 250                 255     


Glu Trp Ala Ser Gly Lys Val Leu Cys Leu Leu Asp Pro Leu Asp Gly 
            260                 265                 270         


Val Tyr Asn Tyr Leu Ala Gln Gln Arg Cys Asn Leu Asp Asp Thr Trp 
        275                 280                 285             


Glu Gly Lys Ile Tyr Arg Val Leu Ala Gly Asn Pro Ala Lys His Asp 
    290                 295                 300                 


Leu Asp Ile Lys Pro Thr Val Ile Ser His Arg Leu His Phe Pro Glu 
305                 310                 315                 320 


Gly Gly Ser Leu Ala Ala Leu Thr Ala His Gln Ala Cys His Leu Pro 
                325                 330                 335     


Leu Glu Thr Phe Thr Arg His Arg Gln Pro Arg Gly Trp Glu Gln Leu 
            340                 345                 350         


Glu Gln Cys Gly Tyr Pro Val Gln Arg Leu Val Ala Leu Tyr Leu Ala 
        355                 360                 365             


Ala Arg Leu Ser Trp Asn Gln Val Asp Gln Val Ile Arg Asn Ala Leu 
    370                 375                 380                 


Ala Ser Pro Gly Ser Gly Gly Asp Leu Gly Glu Ala Ile Arg Glu Gln 
385                 390                 395                 400 


Pro Glu Gln Ala Arg Leu Ala Leu Thr Leu Ala Ala Ala Glu Ser Glu 
                405                 410                 415     


Arg Phe Val Arg Gln Gly Thr Gly Asn Asp Glu Ala Gly Ala Ala Asn 
            420                 425                 430         


Ala Asp Val Val Ser Leu Thr Cys Pro Val Ala Ala Gly Glu Cys Ala 
        435                 440                 445             


Gly Pro Ala Asp Ser Gly Asp Ala Leu Leu Glu Arg Asn Tyr Pro Thr 
    450                 455                 460                 


Gly Ala Glu Phe Leu Gly Asp Gly Gly Asp Val Ser Phe Ser Thr Arg 
465                 470                 475                 480 


Gly Thr Gln Asn Trp Thr Val Glu Arg Leu Leu Gln Ala Glu Phe Val 
                485                 490                 495     


Asp Lys Asp Glu Leu Arg Glu Val Tyr Asn Phe Ala Phe Leu Leu Val 
            500                 505                 510         


Leu Arg Arg Glu Val Tyr Asp Lys Asp Glu Leu Leu Leu Leu Leu Glu 
        515                 520                 525             


Asp Arg Gln Leu Leu Arg Arg Glu Val Phe Cys Gly Phe Arg Asp Leu 
    530                 535                 540                 


Leu Glu Asp Arg Val Tyr Asp Phe Ala Phe Ser Asp Leu Lys Leu Pro 
545                 550                 555                 560 


Gln Leu Cys Thr Glu Leu Lys Leu Pro Gln Leu Cys Thr Glu Leu Lys 
                565                 570                 575     


Asp Glu Leu Lys Asp Glu Leu Val Leu Leu Leu Leu Glu His His His 
            580                 585                 590         


His His His 
        595 


<210>  39
<211>  603
<212>  PRT
<213>  Artificial sequence

<220>
<223>  fusion biogenic polypeptide

<400>  39

Met Ala Glu Gln Leu Val Asp Leu Trp Asn Glu Cys Ala Lys Ala Cys 
1               5                   10                  15      


Val Leu Asp Leu Lys Asp Gly Val Arg Ser Ser Arg Met Ser Val Asp 
            20                  25                  30          


Pro Ala Ile Ala Asp Thr Asn Gly Gln Gly Val Leu His Tyr Cys Met 
        35                  40                  45              


Glu Phe Ser Ser Phe His Leu Phe His His Leu Pro Ala Arg Ala Pro 
    50                  55                  60                  


Leu Ala Pro Ser Glu Leu Gln Pro Leu Glu His Met Ala Glu Glu Ala 
65                  70                  75                  80  


Phe Asp Leu Trp Asn Glu Cys Ala Lys Ala Cys Val Leu Asp Leu Lys 
                85                  90                  95      


Asp Gly Val Arg Ser Ser Arg Met Ser Val Asp Pro Ala Ile Ala Asp 
            100                 105                 110         


Thr Asn Gly Gln Gly Val Leu His Tyr Ser Met Val Leu Glu Gly Gly 
        115                 120                 125             


Asn Asp Ala Leu Lys Leu Ala Ile Asp Asn Ala Leu Ser Ile Thr Ser 
    130                 135                 140                 


Asp Gly Leu Thr Ile Arg Leu Glu Gly Gly Val Glu Pro Asn Lys Pro 
145                 150                 155                 160 


Val Arg Tyr Ser Tyr Thr Arg Gln Ala Arg Gly Ser Trp Ser Leu Asn 
                165                 170                 175     


Trp Leu Val Pro Ile Gly His Glu Lys Pro Ser Asn Ile Lys Val Phe 
            180                 185                 190         


Ile His Glu Leu Asn Ala Gly Asn Gln Leu Ser His Met Ser Pro Ile 
        195                 200                 205             


Tyr Thr Ile Glu Met Gly Asp Glu Leu Leu Ala Lys Leu Ala Arg Asp 
    210                 215                 220                 


Ala Thr Phe Phe Val Arg Ala His Glu Ser Asn Glu Met Gln Pro Thr 
225                 230                 235                 240 


Leu Ala Ile Ser His Ala Gly Val Ser Val Val Met Ala Gln Thr Gln 
                245                 250                 255     


Pro Arg Arg Glu Lys Arg Trp Ser Glu Trp Ala Ser Gly Lys Val Leu 
            260                 265                 270         


Cys Leu Leu Asp Pro Leu Asp Gly Val Tyr Asn Tyr Leu Ala Gln Gln 
        275                 280                 285             


Arg Cys Asn Leu Asp Asp Thr Trp Glu Gly Lys Ile Tyr Arg Val Leu 
    290                 295                 300                 


Ala Gly Asn Pro Ala Lys His Asp Leu Asp Ile Lys Pro Thr Val Ile 
305                 310                 315                 320 


Ser His Arg Leu His Phe Pro Glu Gly Gly Ser Leu Ala Ala Leu Thr 
                325                 330                 335     


Ala His Gln Ala Cys His Leu Pro Leu Glu Thr Phe Thr Arg His Arg 
            340                 345                 350         


Gln Pro Arg Gly Trp Glu Gln Leu Glu Gln Cys Gly Tyr Pro Val Gln 
        355                 360                 365             


Arg Leu Val Ala Leu Tyr Leu Ala Ala Arg Leu Ser Trp Asn Gln Val 
    370                 375                 380                 


Asp Gln Val Ile Arg Asn Ala Leu Ala Ser Pro Gly Ser Gly Gly Asp 
385                 390                 395                 400 


Leu Gly Glu Ala Ile Arg Glu Gln Pro Glu Gln Ala Arg Leu Ala Leu 
                405                 410                 415     


Thr Leu Ala Ala Ala Glu Ser Glu Arg Phe Val Arg Gln Gly Thr Gly 
            420                 425                 430         


Asn Asp Glu Ala Gly Ala Ala Asn Ala Asp Val Val Ser Leu Thr Cys 
        435                 440                 445             


Pro Val Ala Ala Gly Glu Cys Ala Gly Pro Ala Asp Ser Gly Asp Ala 
    450                 455                 460                 


Leu Leu Glu Arg Asn Tyr Pro Thr Gly Ala Glu Phe Leu Gly Asp Gly 
465                 470                 475                 480 


Gly Asp Val Ser Phe Ser Thr Arg Gly Thr Gln Asn Trp Thr Val Glu 
                485                 490                 495     


Arg Leu Leu Gln Ala Glu Phe Val Asp Lys Asp Glu Leu Arg Glu Val 
            500                 505                 510         


Tyr Asn Phe Ala Phe Leu Leu Val Leu Arg Arg Glu Val Tyr Asp Lys 
        515                 520                 525             


Asp Glu Leu Leu Leu Leu Leu Glu Asp Arg Gln Leu Leu Arg Arg Glu 
    530                 535                 540                 


Val Phe Cys Gly Phe Arg Asp Leu Leu Glu Asp Arg Val Tyr Asp Phe 
545                 550                 555                 560 


Ala Phe Ser Asp Leu Lys Leu Pro Gln Leu Cys Thr Glu Leu Lys Leu 
                565                 570                 575     


Pro Gln Leu Cys Thr Glu Leu Lys Asp Glu Leu Lys Asp Glu Leu Val 
            580                 585                 590         


Leu Leu Leu Leu Glu His His His His His His 
        595                 600             


<210>  40
<211>  598
<212>  PRT
<213>  Artificial sequence

<220>
<223>  fusion biogenic polypeptide

<400>  40

Met Ala Glu Gln Leu Val Asp Leu Trp Asn Glu Cys Ala Lys Ala Cys 
1               5                   10                  15      


Val Leu Asp Leu Lys Asp Gly Val Arg Ser Ser Arg Met Ser Val Asp 
            20                  25                  30          


Pro Ala Ile Ala Asp Thr Asn Gly Gln Gly Val Leu His Tyr Cys Met 
        35                  40                  45              


Glu Phe Ser Thr Pro Phe His Pro Leu Pro Ala Arg Lys Pro Leu Pro 
    50                  55                  60                  


Leu Val Pro Leu Glu His Met Ala Glu Glu Ala Phe Asp Leu Trp Asn 
65                  70                  75                  80  


Glu Cys Ala Lys Ala Cys Val Leu Asp Leu Lys Asp Gly Val Arg Ser 
                85                  90                  95      


Ser Arg Met Ser Val Asp Pro Ala Ile Ala Asp Thr Asn Gly Gln Gly 
            100                 105                 110         


Val Leu His Tyr Ser Met Val Leu Glu Gly Gly Asn Asp Ala Leu Lys 
        115                 120                 125             


Leu Ala Ile Asp Asn Ala Leu Ser Ile Thr Ser Asp Gly Leu Thr Ile 
    130                 135                 140                 


Arg Leu Glu Gly Gly Val Glu Pro Asn Lys Pro Val Arg Tyr Ser Tyr 
145                 150                 155                 160 


Thr Arg Gln Ala Arg Gly Ser Trp Ser Leu Asn Trp Leu Val Pro Ile 
                165                 170                 175     


Gly His Glu Lys Pro Ser Asn Ile Lys Val Phe Ile His Glu Leu Asn 
            180                 185                 190         


Ala Gly Asn Gln Leu Ser His Met Ser Pro Ile Tyr Thr Ile Glu Met 
        195                 200                 205             


Gly Asp Glu Leu Leu Ala Lys Leu Ala Arg Asp Ala Thr Phe Phe Val 
    210                 215                 220                 


Arg Ala His Glu Ser Asn Glu Met Gln Pro Thr Leu Ala Ile Ser His 
225                 230                 235                 240 


Ala Gly Val Ser Val Val Met Ala Gln Thr Gln Pro Arg Arg Glu Lys 
                245                 250                 255     


Arg Trp Ser Glu Trp Ala Ser Gly Lys Val Leu Cys Leu Leu Asp Pro 
            260                 265                 270         


Leu Asp Gly Val Tyr Asn Tyr Leu Ala Gln Gln Arg Cys Asn Leu Asp 
        275                 280                 285             


Asp Thr Trp Glu Gly Lys Ile Tyr Arg Val Leu Ala Gly Asn Pro Ala 
    290                 295                 300                 


Lys His Asp Leu Asp Ile Lys Pro Thr Val Ile Ser His Arg Leu His 
305                 310                 315                 320 


Phe Pro Glu Gly Gly Ser Leu Ala Ala Leu Thr Ala His Gln Ala Cys 
                325                 330                 335     


His Leu Pro Leu Glu Thr Phe Thr Arg His Arg Gln Pro Arg Gly Trp 
            340                 345                 350         


Glu Gln Leu Glu Gln Cys Gly Tyr Pro Val Gln Arg Leu Val Ala Leu 
        355                 360                 365             


Tyr Leu Ala Ala Arg Leu Ser Trp Asn Gln Val Asp Gln Val Ile Arg 
    370                 375                 380                 


Asn Ala Leu Ala Ser Pro Gly Ser Gly Gly Asp Leu Gly Glu Ala Ile 
385                 390                 395                 400 


Arg Glu Gln Pro Glu Gln Ala Arg Leu Ala Leu Thr Leu Ala Ala Ala 
                405                 410                 415     


Glu Ser Glu Arg Phe Val Arg Gln Gly Thr Gly Asn Asp Glu Ala Gly 
            420                 425                 430         


Ala Ala Asn Ala Asp Val Val Ser Leu Thr Cys Pro Val Ala Ala Gly 
        435                 440                 445             


Glu Cys Ala Gly Pro Ala Asp Ser Gly Asp Ala Leu Leu Glu Arg Asn 
    450                 455                 460                 


Tyr Pro Thr Gly Ala Glu Phe Leu Gly Asp Gly Gly Asp Val Ser Phe 
465                 470                 475                 480 


Ser Thr Arg Gly Thr Gln Asn Trp Thr Val Glu Arg Leu Leu Gln Ala 
                485                 490                 495     


Glu Phe Val Asp Lys Asp Glu Leu Arg Glu Val Tyr Asn Phe Ala Phe 
            500                 505                 510         


Leu Leu Val Leu Arg Arg Glu Val Tyr Asp Lys Asp Glu Leu Leu Leu 
        515                 520                 525             


Leu Leu Glu Asp Arg Gln Leu Leu Arg Arg Glu Val Phe Cys Gly Phe 
    530                 535                 540                 


Arg Asp Leu Leu Glu Asp Arg Val Tyr Asp Phe Ala Phe Ser Asp Leu 
545                 550                 555                 560 


Lys Leu Pro Gln Leu Cys Thr Glu Leu Lys Leu Pro Gln Leu Cys Thr 
                565                 570                 575     


Glu Leu Lys Asp Glu Leu Lys Asp Glu Leu Val Leu Leu Leu Leu Glu 
            580                 585                 590         


His His His His His His 
        595             


<210>  41
<211>  789
<212>  PRT
<213>  Artificial sequence

<220>
<223>  fusion biogenic polypeptide

<400>  41

Met Ala Glu Gln Leu Val Asp Leu Trp Asn Glu Cys Ala Lys Ala Cys 
1               5                   10                  15      


Val Leu Asp Leu Lys Asp Gly Val Arg Ser Ser Arg Met Ser Val Asp 
            20                  25                  30          


Pro Ala Ile Ala Asp Thr Asn Gly Gln Gly Val Leu His Tyr Cys Met 
        35                  40                  45              


Glu Phe His Met Val Asp Gly Met Ser Ile Arg Ala Lys Arg Arg Lys 
    50                  55                  60                  


Arg Ala Ser Ala Thr Gln Leu Tyr Lys Thr Cys Lys Gln Ala Gly Thr 
65                  70                  75                  80  


Cys Pro Pro Asp Ile Ile Pro Lys Val Glu Gly Lys Thr Ile Ala Glu 
                85                  90                  95      


Gln Ile Leu Gln Tyr Gly Ser Met Gly Val Phe Phe Gly Gly Leu Gly 
            100                 105                 110         


Ile Gly Thr Gly Ser Gly Thr Gly Gly Arg Thr Gly Tyr Ile Pro Leu 
        115                 120                 125             


Gly Thr Arg Pro Pro Thr Ala Thr Asp Thr Leu Ala Pro Val Arg Pro 
    130                 135                 140                 


Pro Leu Thr Val Asp Pro Val Gly Pro Ser Asp Pro Ser Ile Val Ser 
145                 150                 155                 160 


Leu Val Glu Glu Thr Ser Phe Ile Asp Ala Gly Ala Pro Thr Ser Val 
                165                 170                 175     


Pro Ser Ile Pro Pro Asp Val Ser Gly Phe Ser Ile Thr Thr Ser Thr 
            180                 185                 190         


Asp Thr Thr Pro Ala Ile Leu Asp Ile Asn Asn Asn Thr Val Thr Thr 
        195                 200                 205             


Val Thr Thr His Asn Asn Pro Thr Phe Thr Asp Pro Ser Val Leu Gln 
    210                 215                 220                 


Pro Pro Thr Pro Ala Glu Thr Gly Gly His Phe Thr Leu Ser Ser Ser 
225                 230                 235                 240 


Thr Ile Ser Thr His Asn Tyr Glu Glu Ile Pro Met Asp Thr Lys Asp 
                245                 250                 255     


Glu Leu Leu Glu His Met Ala Glu Glu Ala Phe Asp Leu Trp Asn Glu 
            260                 265                 270         


Cys Ala Lys Ala Cys Val Leu Asp Leu Lys Asp Gly Val Arg Ser Ser 
        275                 280                 285             


Arg Met Ser Val Asp Pro Ala Ile Ala Asp Thr Asn Gly Gln Gly Val 
    290                 295                 300                 


Leu His Tyr Ser Met Val Leu Glu Gly Gly Asn Asp Ala Leu Lys Leu 
305                 310                 315                 320 


Ala Ile Asp Asn Ala Leu Ser Ile Thr Ser Asp Gly Leu Thr Ile Arg 
                325                 330                 335     


Leu Glu Gly Gly Val Glu Pro Asn Lys Pro Val Arg Tyr Ser Tyr Thr 
            340                 345                 350         


Arg Gln Ala Arg Gly Ser Trp Ser Leu Asn Trp Leu Val Pro Ile Gly 
        355                 360                 365             


His Glu Lys Pro Ser Asn Ile Lys Val Phe Ile His Glu Leu Asn Ala 
    370                 375                 380                 


Gly Asn Gln Leu Ser His Met Ser Pro Ile Tyr Thr Ile Glu Met Gly 
385                 390                 395                 400 


Asp Glu Leu Leu Ala Lys Leu Ala Arg Asp Ala Thr Phe Phe Val Arg 
                405                 410                 415     


Ala His Glu Ser Asn Glu Met Gln Pro Thr Leu Ala Ile Ser His Ala 
            420                 425                 430         


Gly Val Ser Val Val Met Ala Gln Thr Gln Pro Arg Arg Glu Lys Arg 
        435                 440                 445             


Trp Ser Glu Trp Ala Ser Gly Lys Val Leu Cys Leu Leu Asp Pro Leu 
    450                 455                 460                 


Asp Gly Val Tyr Asn Tyr Leu Ala Gln Gln Arg Cys Asn Leu Asp Asp 
465                 470                 475                 480 


Thr Trp Glu Gly Lys Ile Tyr Arg Val Leu Ala Gly Asn Pro Ala Lys 
                485                 490                 495     


His Asp Leu Asp Ile Lys Pro Thr Val Ile Ser His Arg Leu His Phe 
            500                 505                 510         


Pro Glu Gly Gly Ser Leu Ala Ala Leu Thr Ala His Gln Ala Cys His 
        515                 520                 525             


Leu Pro Leu Glu Thr Phe Thr Arg His Arg Gln Pro Arg Gly Trp Glu 
    530                 535                 540                 


Gln Leu Glu Gln Cys Gly Tyr Pro Val Gln Arg Leu Val Ala Leu Tyr 
545                 550                 555                 560 


Leu Ala Ala Arg Leu Ser Trp Asn Gln Val Asp Gln Val Ile Arg Asn 
                565                 570                 575     


Ala Leu Ala Ser Pro Gly Ser Gly Gly Asp Leu Gly Glu Ala Ile Arg 
            580                 585                 590         


Glu Gln Pro Glu Gln Ala Arg Leu Ala Leu Thr Leu Ala Ala Ala Glu 
        595                 600                 605             


Ser Glu Arg Phe Val Arg Gln Gly Thr Gly Asn Asp Glu Ala Gly Ala 
    610                 615                 620                 


Ala Asn Ala Asp Val Val Ser Leu Thr Cys Pro Val Ala Ala Gly Glu 
625                 630                 635                 640 


Cys Ala Gly Pro Ala Asp Ser Gly Asp Ala Leu Leu Glu Arg Asn Tyr 
                645                 650                 655     


Pro Thr Gly Ala Glu Phe Leu Gly Asp Gly Gly Asp Val Ser Phe Ser 
            660                 665                 670         


Thr Arg Gly Thr Gln Asn Trp Thr Val Glu Arg Leu Leu Gln Ala Glu 
        675                 680                 685             


Phe Val Asp Lys Asp Glu Leu Arg Glu Val Tyr Asn Phe Ala Phe Leu 
    690                 695                 700                 


Leu Val Leu Arg Arg Glu Val Tyr Asp Lys Asp Glu Leu Leu Leu Leu 
705                 710                 715                 720 


Leu Glu Asp Arg Gln Leu Leu Arg Arg Glu Val Phe Cys Gly Phe Arg 
                725                 730                 735     


Asp Leu Leu Glu Asp Arg Val Tyr Asp Phe Ala Phe Ser Asp Leu Lys 
            740                 745                 750         


Leu Pro Gln Leu Cys Thr Glu Leu Lys Leu Pro Gln Leu Cys Thr Glu 
        755                 760                 765             


Leu Lys Asp Glu Leu Lys Asp Glu Leu Val Leu Leu Leu Leu Glu His 
    770                 775                 780                 


His His His His His 
785                 


<210>  42
<211>  569
<212>  PRT
<213>  Artificial sequence

<220>
<223>  fusion biogenic polypeptide

<400>  42

Met Ala Glu Gln Leu Val Asp Leu Trp Asn Glu Cys Ala Lys Ala Cys 
1               5                   10                  15      


Val Leu Asp Leu Lys Asp Gly Val Arg Ser Ser Arg Met Ser Val Asp 
            20                  25                  30          


Pro Ala Ile Ala Asp Thr Asn Gly Gln Gly Val Leu His Tyr Cys Met 
        35                  40                  45              


Glu Phe Ser Phe His Gln Leu Pro Ala Arg Ser Pro Ala Pro Leu Gln 
    50                  55                  60                  


Leu Glu His Met Ala Glu Glu Ala Phe Asp Leu Trp Asn Glu Cys Ala 
65                  70                  75                  80  


Lys Ala Cys Val Leu Asp Leu Lys Asp Gly Val Arg Ser Ser Arg Met 
                85                  90                  95      


Ser Val Asp Pro Ala Ile Ala Asp Thr Asn Gly Gln Gly Val Leu His 
            100                 105                 110         


Tyr Ser Met Val Leu Glu Gly Gly Asn Asp Ala Leu Lys Leu Ala Ile 
        115                 120                 125             


Asp Asn Ala Leu Ser Ile Thr Ser Asp Gly Leu Thr Ile Arg Leu Glu 
    130                 135                 140                 


Gly Gly Val Glu Pro Asn Lys Pro Val Arg Tyr Ser Tyr Thr Arg Gln 
145                 150                 155                 160 


Ala Arg Gly Ser Trp Ser Leu Asn Trp Leu Val Pro Ile Gly His Glu 
                165                 170                 175     


Lys Pro Ser Asn Ile Lys Val Phe Ile His Glu Leu Asn Ala Gly Asn 
            180                 185                 190         


Gln Leu Ser His Met Ser Pro Ile Tyr Thr Ile Glu Met Gly Asp Glu 
        195                 200                 205             


Leu Leu Ala Lys Leu Ala Arg Asp Ala Thr Phe Phe Val Arg Ala His 
    210                 215                 220                 


Glu Ser Asn Glu Met Gln Pro Thr Leu Ala Ile Ser His Ala Gly Val 
225                 230                 235                 240 


Ser Val Val Met Ala Gln Thr Gln Pro Arg Arg Glu Lys Arg Trp Ser 
                245                 250                 255     


Glu Trp Ala Ser Gly Lys Val Leu Cys Leu Leu Asp Pro Leu Asp Gly 
            260                 265                 270         


Val Tyr Asn Tyr Leu Ala Gln Gln Arg Cys Asn Leu Asp Asp Thr Trp 
        275                 280                 285             


Glu Gly Lys Ile Tyr Arg Val Leu Ala Gly Asn Pro Ala Lys His Asp 
    290                 295                 300                 


Leu Asp Ile Lys Pro Thr Val Ile Ser His Arg Leu His Phe Pro Glu 
305                 310                 315                 320 


Gly Gly Ser Leu Ala Ala Leu Thr Ala His Gln Ala Cys His Leu Pro 
                325                 330                 335     


Leu Glu Thr Phe Thr Arg His Arg Gln Pro Arg Gly Trp Glu Gln Leu 
            340                 345                 350         


Glu Gln Cys Gly Tyr Pro Val Gln Arg Leu Val Ala Leu Tyr Leu Ala 
        355                 360                 365             


Ala Arg Leu Ser Trp Asn Gln Val Asp Gln Val Ile Arg Asn Ala Leu 
    370                 375                 380                 


Ala Ser Pro Gly Ser Gly Gly Asp Leu Gly Glu Ala Ile Arg Glu Gln 
385                 390                 395                 400 


Pro Glu Gln Ala Arg Leu Ala Leu Thr Leu Ala Ala Ala Glu Ser Glu 
                405                 410                 415     


Arg Phe Val Arg Gln Gly Thr Gly Asn Asp Glu Ala Gly Ala Ala Asn 
            420                 425                 430         


Ala Asp Val Val Ser Leu Thr Cys Pro Val Ala Ala Gly Glu Cys Ala 
        435                 440                 445             


Gly Pro Ala Asp Ser Gly Asp Ala Leu Leu Glu Arg Asn Tyr Pro Thr 
    450                 455                 460                 


Gly Ala Glu Phe Leu Gly Asp Gly Gly Asp Val Ser Phe Ser Thr Arg 
465                 470                 475                 480 


Gly Thr Gln Asn Trp Thr Val Glu Arg Leu Leu Gln Ala Glu Phe Val 
                485                 490                 495     


Asp Gln Ala Glu Pro Asp Gln Ala Glu Pro Asp Arg Asp Glu Leu Val 
            500                 505                 510         


Leu Arg Ala Arg Ala His Tyr Asn Ile Arg Ala Arg Ala His Tyr Asn 
        515                 520                 525             


Ile Leu Glu Asp Arg Leu Leu Val Leu Arg Ala His Tyr Asn Ile Val 
    530                 535                 540                 


Ile Phe Arg Ala His Tyr Asn Ile Val Ile Phe Lys Asp Glu Leu Leu 
545                 550                 555                 560 


Val Leu Glu His His His His His His 
                565                 


<210>  43
<211>  577
<212>  PRT
<213>  Artificial sequence

<220>
<223>  fusion biogenic polypeptide

<400>  43

Met Ala Glu Gln Leu Val Asp Leu Trp Asn Glu Cys Ala Lys Ala Cys 
1               5                   10                  15      


Val Leu Asp Leu Lys Asp Gly Val Arg Ser Ser Arg Met Ser Val Asp 
            20                  25                  30          


Pro Ala Ile Ala Asp Thr Asn Gly Gln Gly Val Leu His Tyr Cys Met 
        35                  40                  45              


Glu Phe Ser Ser Phe His Leu Phe His His Leu Pro Ala Arg Ala Pro 
    50                  55                  60                  


Leu Ala Pro Ser Glu Leu Gln Pro Leu Glu His Met Ala Glu Glu Ala 
65                  70                  75                  80  


Phe Asp Leu Trp Asn Glu Cys Ala Lys Ala Cys Val Leu Asp Leu Lys 
                85                  90                  95      


Asp Gly Val Arg Ser Ser Arg Met Ser Val Asp Pro Ala Ile Ala Asp 
            100                 105                 110         


Thr Asn Gly Gln Gly Val Leu His Tyr Ser Met Val Leu Glu Gly Gly 
        115                 120                 125             


Asn Asp Ala Leu Lys Leu Ala Ile Asp Asn Ala Leu Ser Ile Thr Ser 
    130                 135                 140                 


Asp Gly Leu Thr Ile Arg Leu Glu Gly Gly Val Glu Pro Asn Lys Pro 
145                 150                 155                 160 


Val Arg Tyr Ser Tyr Thr Arg Gln Ala Arg Gly Ser Trp Ser Leu Asn 
                165                 170                 175     


Trp Leu Val Pro Ile Gly His Glu Lys Pro Ser Asn Ile Lys Val Phe 
            180                 185                 190         


Ile His Glu Leu Asn Ala Gly Asn Gln Leu Ser His Met Ser Pro Ile 
        195                 200                 205             


Tyr Thr Ile Glu Met Gly Asp Glu Leu Leu Ala Lys Leu Ala Arg Asp 
    210                 215                 220                 


Ala Thr Phe Phe Val Arg Ala His Glu Ser Asn Glu Met Gln Pro Thr 
225                 230                 235                 240 


Leu Ala Ile Ser His Ala Gly Val Ser Val Val Met Ala Gln Thr Gln 
                245                 250                 255     


Pro Arg Arg Glu Lys Arg Trp Ser Glu Trp Ala Ser Gly Lys Val Leu 
            260                 265                 270         


Cys Leu Leu Asp Pro Leu Asp Gly Val Tyr Asn Tyr Leu Ala Gln Gln 
        275                 280                 285             


Arg Cys Asn Leu Asp Asp Thr Trp Glu Gly Lys Ile Tyr Arg Val Leu 
    290                 295                 300                 


Ala Gly Asn Pro Ala Lys His Asp Leu Asp Ile Lys Pro Thr Val Ile 
305                 310                 315                 320 


Ser His Arg Leu His Phe Pro Glu Gly Gly Ser Leu Ala Ala Leu Thr 
                325                 330                 335     


Ala His Gln Ala Cys His Leu Pro Leu Glu Thr Phe Thr Arg His Arg 
            340                 345                 350         


Gln Pro Arg Gly Trp Glu Gln Leu Glu Gln Cys Gly Tyr Pro Val Gln 
        355                 360                 365             


Arg Leu Val Ala Leu Tyr Leu Ala Ala Arg Leu Ser Trp Asn Gln Val 
    370                 375                 380                 


Asp Gln Val Ile Arg Asn Ala Leu Ala Ser Pro Gly Ser Gly Gly Asp 
385                 390                 395                 400 


Leu Gly Glu Ala Ile Arg Glu Gln Pro Glu Gln Ala Arg Leu Ala Leu 
                405                 410                 415     


Thr Leu Ala Ala Ala Glu Ser Glu Arg Phe Val Arg Gln Gly Thr Gly 
            420                 425                 430         


Asn Asp Glu Ala Gly Ala Ala Asn Ala Asp Val Val Ser Leu Thr Cys 
        435                 440                 445             


Pro Val Ala Ala Gly Glu Cys Ala Gly Pro Ala Asp Ser Gly Asp Ala 
    450                 455                 460                 


Leu Leu Glu Arg Asn Tyr Pro Thr Gly Ala Glu Phe Leu Gly Asp Gly 
465                 470                 475                 480 


Gly Asp Val Ser Phe Ser Thr Arg Gly Thr Gln Asn Trp Thr Val Glu 
                485                 490                 495     


Arg Leu Leu Gln Ala Glu Phe Val Asp Gln Ala Glu Pro Asp Gln Ala 
            500                 505                 510         


Glu Pro Asp Arg Asp Glu Leu Val Leu Arg Ala Arg Ala His Tyr Asn 
        515                 520                 525             


Ile Arg Ala Arg Ala His Tyr Asn Ile Leu Glu Asp Arg Leu Leu Val 
    530                 535                 540                 


Leu Arg Ala His Tyr Asn Ile Val Ile Phe Arg Ala His Tyr Asn Ile 
545                 550                 555                 560 


Val Ile Phe Lys Asp Glu Leu Leu Val Leu Glu His His His His His 
                565                 570                 575     


His 
    


<210>  44
<211>  572
<212>  PRT
<213>  Artificial sequence

<220>
<223>  fusion biogenic polypeptide

<400>  44

Met Ala Glu Gln Leu Val Asp Leu Trp Asn Glu Cys Ala Lys Ala Cys 
1               5                   10                  15      


Val Leu Asp Leu Lys Asp Gly Val Arg Ser Ser Arg Met Ser Val Asp 
            20                  25                  30          


Pro Ala Ile Ala Asp Thr Asn Gly Gln Gly Val Leu His Tyr Cys Met 
        35                  40                  45              


Glu Phe Ser Thr Pro Phe His Pro Leu Pro Ala Arg Lys Pro Leu Pro 
    50                  55                  60                  


Leu Val Pro Leu Glu His Met Ala Glu Glu Ala Phe Asp Leu Trp Asn 
65                  70                  75                  80  


Glu Cys Ala Lys Ala Cys Val Leu Asp Leu Lys Asp Gly Val Arg Ser 
                85                  90                  95      


Ser Arg Met Ser Val Asp Pro Ala Ile Ala Asp Thr Asn Gly Gln Gly 
            100                 105                 110         


Val Leu His Tyr Ser Met Val Leu Glu Gly Gly Asn Asp Ala Leu Lys 
        115                 120                 125             


Leu Ala Ile Asp Asn Ala Leu Ser Ile Thr Ser Asp Gly Leu Thr Ile 
    130                 135                 140                 


Arg Leu Glu Gly Gly Val Glu Pro Asn Lys Pro Val Arg Tyr Ser Tyr 
145                 150                 155                 160 


Thr Arg Gln Ala Arg Gly Ser Trp Ser Leu Asn Trp Leu Val Pro Ile 
                165                 170                 175     


Gly His Glu Lys Pro Ser Asn Ile Lys Val Phe Ile His Glu Leu Asn 
            180                 185                 190         


Ala Gly Asn Gln Leu Ser His Met Ser Pro Ile Tyr Thr Ile Glu Met 
        195                 200                 205             


Gly Asp Glu Leu Leu Ala Lys Leu Ala Arg Asp Ala Thr Phe Phe Val 
    210                 215                 220                 


Arg Ala His Glu Ser Asn Glu Met Gln Pro Thr Leu Ala Ile Ser His 
225                 230                 235                 240 


Ala Gly Val Ser Val Val Met Ala Gln Thr Gln Pro Arg Arg Glu Lys 
                245                 250                 255     


Arg Trp Ser Glu Trp Ala Ser Gly Lys Val Leu Cys Leu Leu Asp Pro 
            260                 265                 270         


Leu Asp Gly Val Tyr Asn Tyr Leu Ala Gln Gln Arg Cys Asn Leu Asp 
        275                 280                 285             


Asp Thr Trp Glu Gly Lys Ile Tyr Arg Val Leu Ala Gly Asn Pro Ala 
    290                 295                 300                 


Lys His Asp Leu Asp Ile Lys Pro Thr Val Ile Ser His Arg Leu His 
305                 310                 315                 320 


Phe Pro Glu Gly Gly Ser Leu Ala Ala Leu Thr Ala His Gln Ala Cys 
                325                 330                 335     


His Leu Pro Leu Glu Thr Phe Thr Arg His Arg Gln Pro Arg Gly Trp 
            340                 345                 350         


Glu Gln Leu Glu Gln Cys Gly Tyr Pro Val Gln Arg Leu Val Ala Leu 
        355                 360                 365             


Tyr Leu Ala Ala Arg Leu Ser Trp Asn Gln Val Asp Gln Val Ile Arg 
    370                 375                 380                 


Asn Ala Leu Ala Ser Pro Gly Ser Gly Gly Asp Leu Gly Glu Ala Ile 
385                 390                 395                 400 


Arg Glu Gln Pro Glu Gln Ala Arg Leu Ala Leu Thr Leu Ala Ala Ala 
                405                 410                 415     


Glu Ser Glu Arg Phe Val Arg Gln Gly Thr Gly Asn Asp Glu Ala Gly 
            420                 425                 430         


Ala Ala Asn Ala Asp Val Val Ser Leu Thr Cys Pro Val Ala Ala Gly 
        435                 440                 445             


Glu Cys Ala Gly Pro Ala Asp Ser Gly Asp Ala Leu Leu Glu Arg Asn 
    450                 455                 460                 


Tyr Pro Thr Gly Ala Glu Phe Leu Gly Asp Gly Gly Asp Val Ser Phe 
465                 470                 475                 480 


Ser Thr Arg Gly Thr Gln Asn Trp Thr Val Glu Arg Leu Leu Gln Ala 
                485                 490                 495     


Glu Phe Val Asp Gln Ala Glu Pro Asp Gln Ala Glu Pro Asp Arg Asp 
            500                 505                 510         


Glu Leu Val Leu Arg Ala Arg Ala His Tyr Asn Ile Arg Ala Arg Ala 
        515                 520                 525             


His Tyr Asn Ile Leu Glu Asp Arg Leu Leu Val Leu Arg Ala His Tyr 
    530                 535                 540                 


Asn Ile Val Ile Phe Arg Ala His Tyr Asn Ile Val Ile Phe Lys Asp 
545                 550                 555                 560 


Glu Leu Leu Val Leu Glu His His His His His His 
                565                 570         


<210>  45
<211>  763
<212>  PRT
<213>  Artificial sequence

<220>
<223>  fusion biogenic polypeptide

<400>  45

Met Ala Glu Gln Leu Val Asp Leu Trp Asn Glu Cys Ala Lys Ala Cys 
1               5                   10                  15      


Val Leu Asp Leu Lys Asp Gly Val Arg Ser Ser Arg Met Ser Val Asp 
            20                  25                  30          


Pro Ala Ile Ala Asp Thr Asn Gly Gln Gly Val Leu His Tyr Cys Met 
        35                  40                  45              


Glu Phe His Met Val Asp Gly Met Ser Ile Arg Ala Lys Arg Arg Lys 
    50                  55                  60                  


Arg Ala Ser Ala Thr Gln Leu Tyr Lys Thr Cys Lys Gln Ala Gly Thr 
65                  70                  75                  80  


Cys Pro Pro Asp Ile Ile Pro Lys Val Glu Gly Lys Thr Ile Ala Glu 
                85                  90                  95      


Gln Ile Leu Gln Tyr Gly Ser Met Gly Val Phe Phe Gly Gly Leu Gly 
            100                 105                 110         


Ile Gly Thr Gly Ser Gly Thr Gly Gly Arg Thr Gly Tyr Ile Pro Leu 
        115                 120                 125             


Gly Thr Arg Pro Pro Thr Ala Thr Asp Thr Leu Ala Pro Val Arg Pro 
    130                 135                 140                 


Pro Leu Thr Val Asp Pro Val Gly Pro Ser Asp Pro Ser Ile Val Ser 
145                 150                 155                 160 


Leu Val Glu Glu Thr Ser Phe Ile Asp Ala Gly Ala Pro Thr Ser Val 
                165                 170                 175     


Pro Ser Ile Pro Pro Asp Val Ser Gly Phe Ser Ile Thr Thr Ser Thr 
            180                 185                 190         


Asp Thr Thr Pro Ala Ile Leu Asp Ile Asn Asn Asn Thr Val Thr Thr 
        195                 200                 205             


Val Thr Thr His Asn Asn Pro Thr Phe Thr Asp Pro Ser Val Leu Gln 
    210                 215                 220                 


Pro Pro Thr Pro Ala Glu Thr Gly Gly His Phe Thr Leu Ser Ser Ser 
225                 230                 235                 240 


Thr Ile Ser Thr His Asn Tyr Glu Glu Ile Pro Met Asp Thr Lys Asp 
                245                 250                 255     


Glu Leu Leu Glu His Met Ala Glu Glu Ala Phe Asp Leu Trp Asn Glu 
            260                 265                 270         


Cys Ala Lys Ala Cys Val Leu Asp Leu Lys Asp Gly Val Arg Ser Ser 
        275                 280                 285             


Arg Met Ser Val Asp Pro Ala Ile Ala Asp Thr Asn Gly Gln Gly Val 
    290                 295                 300                 


Leu His Tyr Ser Met Val Leu Glu Gly Gly Asn Asp Ala Leu Lys Leu 
305                 310                 315                 320 


Ala Ile Asp Asn Ala Leu Ser Ile Thr Ser Asp Gly Leu Thr Ile Arg 
                325                 330                 335     


Leu Glu Gly Gly Val Glu Pro Asn Lys Pro Val Arg Tyr Ser Tyr Thr 
            340                 345                 350         


Arg Gln Ala Arg Gly Ser Trp Ser Leu Asn Trp Leu Val Pro Ile Gly 
        355                 360                 365             


His Glu Lys Pro Ser Asn Ile Lys Val Phe Ile His Glu Leu Asn Ala 
    370                 375                 380                 


Gly Asn Gln Leu Ser His Met Ser Pro Ile Tyr Thr Ile Glu Met Gly 
385                 390                 395                 400 


Asp Glu Leu Leu Ala Lys Leu Ala Arg Asp Ala Thr Phe Phe Val Arg 
                405                 410                 415     


Ala His Glu Ser Asn Glu Met Gln Pro Thr Leu Ala Ile Ser His Ala 
            420                 425                 430         


Gly Val Ser Val Val Met Ala Gln Thr Gln Pro Arg Arg Glu Lys Arg 
        435                 440                 445             


Trp Ser Glu Trp Ala Ser Gly Lys Val Leu Cys Leu Leu Asp Pro Leu 
    450                 455                 460                 


Asp Gly Val Tyr Asn Tyr Leu Ala Gln Gln Arg Cys Asn Leu Asp Asp 
465                 470                 475                 480 


Thr Trp Glu Gly Lys Ile Tyr Arg Val Leu Ala Gly Asn Pro Ala Lys 
                485                 490                 495     


His Asp Leu Asp Ile Lys Pro Thr Val Ile Ser His Arg Leu His Phe 
            500                 505                 510         


Pro Glu Gly Gly Ser Leu Ala Ala Leu Thr Ala His Gln Ala Cys His 
        515                 520                 525             


Leu Pro Leu Glu Thr Phe Thr Arg His Arg Gln Pro Arg Gly Trp Glu 
    530                 535                 540                 


Gln Leu Glu Gln Cys Gly Tyr Pro Val Gln Arg Leu Val Ala Leu Tyr 
545                 550                 555                 560 


Leu Ala Ala Arg Leu Ser Trp Asn Gln Val Asp Gln Val Ile Arg Asn 
                565                 570                 575     


Ala Leu Ala Ser Pro Gly Ser Gly Gly Asp Leu Gly Glu Ala Ile Arg 
            580                 585                 590         


Glu Gln Pro Glu Gln Ala Arg Leu Ala Leu Thr Leu Ala Ala Ala Glu 
        595                 600                 605             


Ser Glu Arg Phe Val Arg Gln Gly Thr Gly Asn Asp Glu Ala Gly Ala 
    610                 615                 620                 


Ala Asn Ala Asp Val Val Ser Leu Thr Cys Pro Val Ala Ala Gly Glu 
625                 630                 635                 640 


Cys Ala Gly Pro Ala Asp Ser Gly Asp Ala Leu Leu Glu Arg Asn Tyr 
                645                 650                 655     


Pro Thr Gly Ala Glu Phe Leu Gly Asp Gly Gly Asp Val Ser Phe Ser 
            660                 665                 670         


Thr Arg Gly Thr Gln Asn Trp Thr Val Glu Arg Leu Leu Gln Ala Glu 
        675                 680                 685             


Phe Val Asp Gln Ala Glu Pro Asp Gln Ala Glu Pro Asp Arg Asp Glu 
    690                 695                 700                 


Leu Val Leu Arg Ala Arg Ala His Tyr Asn Ile Arg Ala Arg Ala His 
705                 710                 715                 720 


Tyr Asn Ile Leu Glu Asp Arg Leu Leu Val Leu Arg Ala His Tyr Asn 
                725                 730                 735     


Ile Val Ile Phe Arg Ala His Tyr Asn Ile Val Ile Phe Lys Asp Glu 
            740                 745                 750         


Leu Leu Val Leu Glu His His His His His His 
        755                 760             


<210>  46
<211>  553
<212>  PRT
<213>  Artificial sequence

<220>
<223>  fusion biogenic polypeptide

<400>  46

Met Ala Glu Gln Leu Val Asp Leu Trp Asn Glu Cys Ala Lys Ala Cys 
1               5                   10                  15      


Val Leu Asp Leu Lys Asp Gly Val Arg Ser Ser Arg Met Ser Val Asp 
            20                  25                  30          


Pro Ala Ile Ala Asp Thr Asn Gly Gln Gly Val Leu His Tyr Cys Met 
        35                  40                  45              


Glu Phe Ser Phe His Gln Leu Pro Ala Arg Ser Pro Ala Pro Leu Gln 
    50                  55                  60                  


Leu Glu His Met Ala Glu Glu Ala Phe Asp Leu Trp Asn Glu Cys Ala 
65                  70                  75                  80  


Lys Ala Cys Val Leu Asp Leu Lys Asp Gly Val Arg Ser Ser Arg Met 
                85                  90                  95      


Ser Val Asp Pro Ala Ile Ala Asp Thr Asn Gly Gln Gly Val Leu His 
            100                 105                 110         


Tyr Ser Met Val Leu Glu Gly Gly Asn Asp Ala Leu Lys Leu Ala Ile 
        115                 120                 125             


Asp Asn Ala Leu Ser Ile Thr Ser Asp Gly Leu Thr Ile Arg Leu Glu 
    130                 135                 140                 


Gly Gly Val Glu Pro Asn Lys Pro Val Arg Tyr Ser Tyr Thr Arg Gln 
145                 150                 155                 160 


Ala Arg Gly Ser Trp Ser Leu Asn Trp Leu Val Pro Ile Gly His Glu 
                165                 170                 175     


Lys Pro Ser Asn Ile Lys Val Phe Ile His Glu Leu Asn Ala Gly Asn 
            180                 185                 190         


Gln Leu Ser His Met Ser Pro Ile Tyr Thr Ile Glu Met Gly Asp Glu 
        195                 200                 205             


Leu Leu Ala Lys Leu Ala Arg Asp Ala Thr Phe Phe Val Arg Ala His 
    210                 215                 220                 


Glu Ser Asn Glu Met Gln Pro Thr Leu Ala Ile Ser His Ala Gly Val 
225                 230                 235                 240 


Ser Val Val Met Ala Gln Thr Gln Pro Arg Arg Glu Lys Arg Trp Ser 
                245                 250                 255     


Glu Trp Ala Ser Gly Lys Val Leu Cys Leu Leu Asp Pro Leu Asp Gly 
            260                 265                 270         


Val Tyr Asn Tyr Leu Ala Gln Gln Arg Cys Asn Leu Asp Asp Thr Trp 
        275                 280                 285             


Glu Gly Lys Ile Tyr Arg Val Leu Ala Gly Asn Pro Ala Lys His Asp 
    290                 295                 300                 


Leu Asp Ile Lys Pro Thr Val Ile Ser His Arg Leu His Phe Pro Glu 
305                 310                 315                 320 


Gly Gly Ser Leu Ala Ala Leu Thr Ala His Gln Ala Cys His Leu Pro 
                325                 330                 335     


Leu Glu Thr Phe Thr Arg His Arg Gln Pro Arg Gly Trp Glu Gln Leu 
            340                 345                 350         


Glu Gln Cys Gly Tyr Pro Val Gln Arg Leu Val Ala Leu Tyr Leu Ala 
        355                 360                 365             


Ala Arg Leu Ser Trp Asn Gln Val Asp Gln Val Ile Arg Asn Ala Leu 
    370                 375                 380                 


Ala Ser Pro Gly Ser Gly Gly Asp Leu Gly Glu Ala Ile Arg Glu Gln 
385                 390                 395                 400 


Pro Glu Gln Ala Arg Leu Ala Leu Thr Leu Ala Ala Ala Glu Ser Glu 
                405                 410                 415     


Arg Phe Val Arg Gln Gly Thr Gly Asn Asp Glu Ala Gly Ala Ala Asn 
            420                 425                 430         


Ala Asp Val Val Ser Leu Thr Cys Pro Val Ala Ala Gly Glu Cys Ala 
        435                 440                 445             


Gly Pro Ala Asp Ser Gly Asp Ala Leu Leu Glu Arg Asn Tyr Pro Thr 
    450                 455                 460                 


Gly Ala Glu Phe Leu Gly Asp Gly Gly Asp Val Glu Phe Val Asp Val 
465                 470                 475                 480 


Phe Leu Gln Lys Tyr Pro His Thr His Leu Val His Gln Ala Leu Asp 
                485                 490                 495     


Val Phe Leu Gln Lys Tyr Pro His Thr His Leu Val His Gln Ala Leu 
            500                 505                 510         


Asp Val Phe Leu Gln Lys Tyr Pro His Thr His Leu Val His Gln Ala 
        515                 520                 525             


Leu Asp Val Phe Leu Gln Lys Tyr Pro His Thr His Leu Val His Gln 
    530                 535                 540                 


Ala Leu Glu His His His His His His 
545                 550             


<210>  47
<211>  561
<212>  PRT
<213>  Artificial sequence

<220>
<223>  fusion biogenic polypeptide

<400>  47

Met Ala Glu Gln Leu Val Asp Leu Trp Asn Glu Cys Ala Lys Ala Cys 
1               5                   10                  15      


Val Leu Asp Leu Lys Asp Gly Val Arg Ser Ser Arg Met Ser Val Asp 
            20                  25                  30          


Pro Ala Ile Ala Asp Thr Asn Gly Gln Gly Val Leu His Tyr Cys Met 
        35                  40                  45              


Glu Phe Ser Ser Phe His Leu Phe His His Leu Pro Ala Arg Ala Pro 
    50                  55                  60                  


Leu Ala Pro Ser Glu Leu Gln Pro Leu Glu His Met Ala Glu Glu Ala 
65                  70                  75                  80  


Phe Asp Leu Trp Asn Glu Cys Ala Lys Ala Cys Val Leu Asp Leu Lys 
                85                  90                  95      


Asp Gly Val Arg Ser Ser Arg Met Ser Val Asp Pro Ala Ile Ala Asp 
            100                 105                 110         


Thr Asn Gly Gln Gly Val Leu His Tyr Ser Met Val Leu Glu Gly Gly 
        115                 120                 125             


Asn Asp Ala Leu Lys Leu Ala Ile Asp Asn Ala Leu Ser Ile Thr Ser 
    130                 135                 140                 


Asp Gly Leu Thr Ile Arg Leu Glu Gly Gly Val Glu Pro Asn Lys Pro 
145                 150                 155                 160 


Val Arg Tyr Ser Tyr Thr Arg Gln Ala Arg Gly Ser Trp Ser Leu Asn 
                165                 170                 175     


Trp Leu Val Pro Ile Gly His Glu Lys Pro Ser Asn Ile Lys Val Phe 
            180                 185                 190         


Ile His Glu Leu Asn Ala Gly Asn Gln Leu Ser His Met Ser Pro Ile 
        195                 200                 205             


Tyr Thr Ile Glu Met Gly Asp Glu Leu Leu Ala Lys Leu Ala Arg Asp 
    210                 215                 220                 


Ala Thr Phe Phe Val Arg Ala His Glu Ser Asn Glu Met Gln Pro Thr 
225                 230                 235                 240 


Leu Ala Ile Ser His Ala Gly Val Ser Val Val Met Ala Gln Thr Gln 
                245                 250                 255     


Pro Arg Arg Glu Lys Arg Trp Ser Glu Trp Ala Ser Gly Lys Val Leu 
            260                 265                 270         


Cys Leu Leu Asp Pro Leu Asp Gly Val Tyr Asn Tyr Leu Ala Gln Gln 
        275                 280                 285             


Arg Cys Asn Leu Asp Asp Thr Trp Glu Gly Lys Ile Tyr Arg Val Leu 
    290                 295                 300                 


Ala Gly Asn Pro Ala Lys His Asp Leu Asp Ile Lys Pro Thr Val Ile 
305                 310                 315                 320 


Ser His Arg Leu His Phe Pro Glu Gly Gly Ser Leu Ala Ala Leu Thr 
                325                 330                 335     


Ala His Gln Ala Cys His Leu Pro Leu Glu Thr Phe Thr Arg His Arg 
            340                 345                 350         


Gln Pro Arg Gly Trp Glu Gln Leu Glu Gln Cys Gly Tyr Pro Val Gln 
        355                 360                 365             


Arg Leu Val Ala Leu Tyr Leu Ala Ala Arg Leu Ser Trp Asn Gln Val 
    370                 375                 380                 


Asp Gln Val Ile Arg Asn Ala Leu Ala Ser Pro Gly Ser Gly Gly Asp 
385                 390                 395                 400 


Leu Gly Glu Ala Ile Arg Glu Gln Pro Glu Gln Ala Arg Leu Ala Leu 
                405                 410                 415     


Thr Leu Ala Ala Ala Glu Ser Glu Arg Phe Val Arg Gln Gly Thr Gly 
            420                 425                 430         


Asn Asp Glu Ala Gly Ala Ala Asn Ala Asp Val Val Ser Leu Thr Cys 
        435                 440                 445             


Pro Val Ala Ala Gly Glu Cys Ala Gly Pro Ala Asp Ser Gly Asp Ala 
    450                 455                 460                 


Leu Leu Glu Arg Asn Tyr Pro Thr Gly Ala Glu Phe Leu Gly Asp Gly 
465                 470                 475                 480 


Gly Asp Val Glu Phe Val Asp Val Phe Leu Gln Lys Tyr Pro His Thr 
                485                 490                 495     


His Leu Val His Gln Ala Leu Asp Val Phe Leu Gln Lys Tyr Pro His 
            500                 505                 510         


Thr His Leu Val His Gln Ala Leu Asp Val Phe Leu Gln Lys Tyr Pro 
        515                 520                 525             


His Thr His Leu Val His Gln Ala Leu Asp Val Phe Leu Gln Lys Tyr 
    530                 535                 540                 


Pro His Thr His Leu Val His Gln Ala Leu Glu His His His His His 
545                 550                 555                 560 


His 
    


<210>  48
<211>  556
<212>  PRT
<213>  Artificial sequence

<220>
<223>  fusion biogenic polypeptide

<400>  48

Met Ala Glu Gln Leu Val Asp Leu Trp Asn Glu Cys Ala Lys Ala Cys 
1               5                   10                  15      


Val Leu Asp Leu Lys Asp Gly Val Arg Ser Ser Arg Met Ser Val Asp 
            20                  25                  30          


Pro Ala Ile Ala Asp Thr Asn Gly Gln Gly Val Leu His Tyr Cys Met 
        35                  40                  45              


Glu Phe Ser Thr Pro Phe His Pro Leu Pro Ala Arg Lys Pro Leu Pro 
    50                  55                  60                  


Leu Val Pro Leu Glu His Met Ala Glu Glu Ala Phe Asp Leu Trp Asn 
65                  70                  75                  80  


Glu Cys Ala Lys Ala Cys Val Leu Asp Leu Lys Asp Gly Val Arg Ser 
                85                  90                  95      


Ser Arg Met Ser Val Asp Pro Ala Ile Ala Asp Thr Asn Gly Gln Gly 
            100                 105                 110         


Val Leu His Tyr Ser Met Val Leu Glu Gly Gly Asn Asp Ala Leu Lys 
        115                 120                 125             


Leu Ala Ile Asp Asn Ala Leu Ser Ile Thr Ser Asp Gly Leu Thr Ile 
    130                 135                 140                 


Arg Leu Glu Gly Gly Val Glu Pro Asn Lys Pro Val Arg Tyr Ser Tyr 
145                 150                 155                 160 


Thr Arg Gln Ala Arg Gly Ser Trp Ser Leu Asn Trp Leu Val Pro Ile 
                165                 170                 175     


Gly His Glu Lys Pro Ser Asn Ile Lys Val Phe Ile His Glu Leu Asn 
            180                 185                 190         


Ala Gly Asn Gln Leu Ser His Met Ser Pro Ile Tyr Thr Ile Glu Met 
        195                 200                 205             


Gly Asp Glu Leu Leu Ala Lys Leu Ala Arg Asp Ala Thr Phe Phe Val 
    210                 215                 220                 


Arg Ala His Glu Ser Asn Glu Met Gln Pro Thr Leu Ala Ile Ser His 
225                 230                 235                 240 


Ala Gly Val Ser Val Val Met Ala Gln Thr Gln Pro Arg Arg Glu Lys 
                245                 250                 255     


Arg Trp Ser Glu Trp Ala Ser Gly Lys Val Leu Cys Leu Leu Asp Pro 
            260                 265                 270         


Leu Asp Gly Val Tyr Asn Tyr Leu Ala Gln Gln Arg Cys Asn Leu Asp 
        275                 280                 285             


Asp Thr Trp Glu Gly Lys Ile Tyr Arg Val Leu Ala Gly Asn Pro Ala 
    290                 295                 300                 


Lys His Asp Leu Asp Ile Lys Pro Thr Val Ile Ser His Arg Leu His 
305                 310                 315                 320 


Phe Pro Glu Gly Gly Ser Leu Ala Ala Leu Thr Ala His Gln Ala Cys 
                325                 330                 335     


His Leu Pro Leu Glu Thr Phe Thr Arg His Arg Gln Pro Arg Gly Trp 
            340                 345                 350         


Glu Gln Leu Glu Gln Cys Gly Tyr Pro Val Gln Arg Leu Val Ala Leu 
        355                 360                 365             


Tyr Leu Ala Ala Arg Leu Ser Trp Asn Gln Val Asp Gln Val Ile Arg 
    370                 375                 380                 


Asn Ala Leu Ala Ser Pro Gly Ser Gly Gly Asp Leu Gly Glu Ala Ile 
385                 390                 395                 400 


Arg Glu Gln Pro Glu Gln Ala Arg Leu Ala Leu Thr Leu Ala Ala Ala 
                405                 410                 415     


Glu Ser Glu Arg Phe Val Arg Gln Gly Thr Gly Asn Asp Glu Ala Gly 
            420                 425                 430         


Ala Ala Asn Ala Asp Val Val Ser Leu Thr Cys Pro Val Ala Ala Gly 
        435                 440                 445             


Glu Cys Ala Gly Pro Ala Asp Ser Gly Asp Ala Leu Leu Glu Arg Asn 
    450                 455                 460                 


Tyr Pro Thr Gly Ala Glu Phe Leu Gly Asp Gly Gly Asp Val Glu Phe 
465                 470                 475                 480 


Val Asp Val Phe Leu Gln Lys Tyr Pro His Thr His Leu Val His Gln 
                485                 490                 495     


Ala Leu Asp Val Phe Leu Gln Lys Tyr Pro His Thr His Leu Val His 
            500                 505                 510         


Gln Ala Leu Asp Val Phe Leu Gln Lys Tyr Pro His Thr His Leu Val 
        515                 520                 525             


His Gln Ala Leu Asp Val Phe Leu Gln Lys Tyr Pro His Thr His Leu 
    530                 535                 540                 


Val His Gln Ala Leu Glu His His His His His His 
545                 550                 555     


<210>  49
<211>  758
<212>  PRT
<213>  Artificial sequence

<220>
<223>  fusion biogenic polypeptide

<400>  49

Met Ala Glu Gln Leu Val Asp Leu Trp Asn Glu Cys Ala Lys Ala Cys 
1               5                   10                  15      


Val Leu Asp Leu Lys Asp Gly Val Arg Ser Ser Arg Met Ser Val Asp 
            20                  25                  30          


Pro Ala Ile Ala Asp Thr Asn Gly Gln Gly Val Leu His Tyr Cys Met 
        35                  40                  45              


Glu Phe Ser Phe His Gln Leu Pro Ala Arg Ser Pro Ala Pro Leu Gln 
    50                  55                  60                  


Leu Glu His Met Ala Glu Glu Ala Phe Asp Leu Trp Asn Glu Cys Ala 
65                  70                  75                  80  


Lys Ala Cys Val Leu Asp Leu Lys Asp Gly Val Arg Ser Ser Arg Met 
                85                  90                  95      


Ser Val Asp Pro Ala Ile Ala Asp Thr Asn Gly Gln Gly Val Leu His 
            100                 105                 110         


Tyr Ser Met Val Leu Glu Gly Gly Asn Asp Ala Leu Lys Leu Ala Ile 
        115                 120                 125             


Asp Asn Ala Leu Ser Ile Thr Ser Asp Gly Leu Thr Ile Arg Leu Glu 
    130                 135                 140                 


Gly Gly Val Glu Pro Asn Lys Pro Val Arg Tyr Ser Tyr Thr Arg Gln 
145                 150                 155                 160 


Ala Arg Gly Ser Trp Ser Leu Asn Trp Leu Val Pro Ile Gly His Glu 
                165                 170                 175     


Lys Pro Ser Asn Ile Lys Val Phe Ile His Glu Leu Asn Ala Gly Asn 
            180                 185                 190         


Gln Leu Ser His Met Ser Pro Ile Tyr Thr Ile Glu Met Gly Asp Glu 
        195                 200                 205             


Leu Leu Ala Lys Leu Ala Arg Asp Ala Thr Phe Phe Val Arg Ala His 
    210                 215                 220                 


Glu Ser Asn Glu Met Gln Pro Thr Leu Ala Ile Ser His Ala Gly Val 
225                 230                 235                 240 


Ser Val Val Met Ala Gln Thr Gln Pro Arg Arg Glu Lys Arg Trp Ser 
                245                 250                 255     


Glu Trp Ala Ser Gly Lys Val Leu Cys Leu Leu Asp Pro Leu Asp Gly 
            260                 265                 270         


Val Tyr Asn Tyr Leu Ala Gln Gln Arg Cys Asn Leu Asp Asp Thr Trp 
        275                 280                 285             


Glu Gly Lys Ile Tyr Arg Val Leu Ala Gly Asn Pro Ala Lys His Asp 
    290                 295                 300                 


Leu Asp Ile Lys Pro Thr Val Ile Ser His Arg Leu His Phe Pro Glu 
305                 310                 315                 320 


Gly Gly Ser Leu Ala Ala Leu Thr Ala His Gln Ala Cys His Leu Pro 
                325                 330                 335     


Leu Glu Thr Phe Thr Arg His Arg Gln Pro Arg Gly Trp Glu Gln Leu 
            340                 345                 350         


Glu Gln Cys Gly Tyr Pro Val Gln Arg Leu Val Ala Leu Tyr Leu Ala 
        355                 360                 365             


Ala Arg Leu Ser Trp Asn Gln Val Asp Gln Val Ile Arg Asn Ala Leu 
    370                 375                 380                 


Ala Ser Pro Gly Ser Gly Gly Asp Leu Gly Glu Ala Ile Arg Glu Gln 
385                 390                 395                 400 


Pro Glu Gln Ala Arg Leu Ala Leu Thr Leu Ala Ala Ala Glu Ser Glu 
                405                 410                 415     


Arg Phe Val Arg Gln Gly Thr Gly Asn Asp Glu Ala Gly Ala Ala Asn 
            420                 425                 430         


Ala Asp Val Val Ser Leu Thr Cys Pro Val Ala Ala Gly Glu Cys Ala 
        435                 440                 445             


Gly Pro Ala Asp Ser Gly Asp Ala Leu Leu Glu Arg Asn Tyr Pro Thr 
    450                 455                 460                 


Gly Ala Glu Phe Leu Gly Asp Gly Gly Asp Val Glu Phe Leu Leu Glu 
465                 470                 475                 480 


Pro His Thr His Leu Val His Gln Ala Asn Val Leu Leu Ala Leu Gln 
                485                 490                 495     


Leu Leu Leu Glu Asp Arg Glu Phe Val Phe Leu Gln Lys Tyr Pro His 
            500                 505                 510         


Val Glu Pro His Thr His Leu Val His Gln Ala Asn Val Leu Leu Ala 
        515                 520                 525             


Leu Gln Leu Leu Leu Glu Asp Arg Glu Phe Val Phe Leu Gln Lys Tyr 
    530                 535                 540                 


Pro His Val Glu Pro His Thr His Leu Val His Gln Ala Asn Val Leu 
545                 550                 555                 560 


Leu Ala Leu Gln Leu Leu Leu Glu Asp Arg Glu Phe Val Phe Leu Gln 
                565                 570                 575     


Lys Tyr Pro His Val Glu Pro His Thr His Leu Val His Gln Ala Asn 
            580                 585                 590         


Val Leu Leu Ala Leu Gln Leu Leu Leu Glu Asp Arg Glu Phe Val Phe 
        595                 600                 605             


Leu Gln Lys Tyr Pro His Val Glu Pro His Thr His Leu Val His Gln 
    610                 615                 620                 


Ala Asn Val Leu Leu Ala Leu Gln Leu Leu Leu Glu Asp Arg Glu Phe 
625                 630                 635                 640 


Val Phe Leu Gln Lys Tyr Pro His Val Glu Pro His Thr His Leu Val 
                645                 650                 655     


His Gln Ala Asn Val Leu Leu Ala Leu Gln Leu Leu Leu Glu Asp Arg 
            660                 665                 670         


Glu Phe Val Phe Leu Gln Lys Tyr Pro His Val Glu Pro His Thr His 
        675                 680                 685             


Leu Val His Gln Ala Asn Val Leu Leu Ala Leu Gln Leu Leu Leu Glu 
    690                 695                 700                 


Asp Arg Glu Phe Val Phe Leu Gln Lys Tyr Pro His Val Glu Pro His 
705                 710                 715                 720 


Thr His Leu Val His Gln Ala Asn Val Leu Leu Ala Leu Gln Leu Leu 
                725                 730                 735     


Leu Glu Asp Arg Glu Phe Val Phe Leu Gln Lys Tyr Pro His Val Glu 
            740                 745                 750         


His His His His His His 
        755             


<210>  50
<211>  766
<212>  PRT
<213>  Artificial sequence

<220>
<223>  fusion biogenic polypeptide

<400>  50

Met Ala Glu Gln Leu Val Asp Leu Trp Asn Glu Cys Ala Lys Ala Cys 
1               5                   10                  15      


Val Leu Asp Leu Lys Asp Gly Val Arg Ser Ser Arg Met Ser Val Asp 
            20                  25                  30          


Pro Ala Ile Ala Asp Thr Asn Gly Gln Gly Val Leu His Tyr Cys Met 
        35                  40                  45              


Glu Phe Ser Ser Phe His Leu Phe His His Leu Pro Ala Arg Ala Pro 
    50                  55                  60                  


Leu Ala Pro Ser Glu Leu Gln Pro Leu Glu His Met Ala Glu Glu Ala 
65                  70                  75                  80  


Phe Asp Leu Trp Asn Glu Cys Ala Lys Ala Cys Val Leu Asp Leu Lys 
                85                  90                  95      


Asp Gly Val Arg Ser Ser Arg Met Ser Val Asp Pro Ala Ile Ala Asp 
            100                 105                 110         


Thr Asn Gly Gln Gly Val Leu His Tyr Ser Met Val Leu Glu Gly Gly 
        115                 120                 125             


Asn Asp Ala Leu Lys Leu Ala Ile Asp Asn Ala Leu Ser Ile Thr Ser 
    130                 135                 140                 


Asp Gly Leu Thr Ile Arg Leu Glu Gly Gly Val Glu Pro Asn Lys Pro 
145                 150                 155                 160 


Val Arg Tyr Ser Tyr Thr Arg Gln Ala Arg Gly Ser Trp Ser Leu Asn 
                165                 170                 175     


Trp Leu Val Pro Ile Gly His Glu Lys Pro Ser Asn Ile Lys Val Phe 
            180                 185                 190         


Ile His Glu Leu Asn Ala Gly Asn Gln Leu Ser His Met Ser Pro Ile 
        195                 200                 205             


Tyr Thr Ile Glu Met Gly Asp Glu Leu Leu Ala Lys Leu Ala Arg Asp 
    210                 215                 220                 


Ala Thr Phe Phe Val Arg Ala His Glu Ser Asn Glu Met Gln Pro Thr 
225                 230                 235                 240 


Leu Ala Ile Ser His Ala Gly Val Ser Val Val Met Ala Gln Thr Gln 
                245                 250                 255     


Pro Arg Arg Glu Lys Arg Trp Ser Glu Trp Ala Ser Gly Lys Val Leu 
            260                 265                 270         


Cys Leu Leu Asp Pro Leu Asp Gly Val Tyr Asn Tyr Leu Ala Gln Gln 
        275                 280                 285             


Arg Cys Asn Leu Asp Asp Thr Trp Glu Gly Lys Ile Tyr Arg Val Leu 
    290                 295                 300                 


Ala Gly Asn Pro Ala Lys His Asp Leu Asp Ile Lys Pro Thr Val Ile 
305                 310                 315                 320 


Ser His Arg Leu His Phe Pro Glu Gly Gly Ser Leu Ala Ala Leu Thr 
                325                 330                 335     


Ala His Gln Ala Cys His Leu Pro Leu Glu Thr Phe Thr Arg His Arg 
            340                 345                 350         


Gln Pro Arg Gly Trp Glu Gln Leu Glu Gln Cys Gly Tyr Pro Val Gln 
        355                 360                 365             


Arg Leu Val Ala Leu Tyr Leu Ala Ala Arg Leu Ser Trp Asn Gln Val 
    370                 375                 380                 


Asp Gln Val Ile Arg Asn Ala Leu Ala Ser Pro Gly Ser Gly Gly Asp 
385                 390                 395                 400 


Leu Gly Glu Ala Ile Arg Glu Gln Pro Glu Gln Ala Arg Leu Ala Leu 
                405                 410                 415     


Thr Leu Ala Ala Ala Glu Ser Glu Arg Phe Val Arg Gln Gly Thr Gly 
            420                 425                 430         


Asn Asp Glu Ala Gly Ala Ala Asn Ala Asp Val Val Ser Leu Thr Cys 
        435                 440                 445             


Pro Val Ala Ala Gly Glu Cys Ala Gly Pro Ala Asp Ser Gly Asp Ala 
    450                 455                 460                 


Leu Leu Glu Arg Asn Tyr Pro Thr Gly Ala Glu Phe Leu Gly Asp Gly 
465                 470                 475                 480 


Gly Asp Val Glu Phe Leu Leu Glu Pro His Thr His Leu Val His Gln 
                485                 490                 495     


Ala Asn Val Leu Leu Ala Leu Gln Leu Leu Leu Glu Asp Arg Glu Phe 
            500                 505                 510         


Val Phe Leu Gln Lys Tyr Pro His Val Glu Pro His Thr His Leu Val 
        515                 520                 525             


His Gln Ala Asn Val Leu Leu Ala Leu Gln Leu Leu Leu Glu Asp Arg 
    530                 535                 540                 


Glu Phe Val Phe Leu Gln Lys Tyr Pro His Val Glu Pro His Thr His 
545                 550                 555                 560 


Leu Val His Gln Ala Asn Val Leu Leu Ala Leu Gln Leu Leu Leu Glu 
                565                 570                 575     


Asp Arg Glu Phe Val Phe Leu Gln Lys Tyr Pro His Val Glu Pro His 
            580                 585                 590         


Thr His Leu Val His Gln Ala Asn Val Leu Leu Ala Leu Gln Leu Leu 
        595                 600                 605             


Leu Glu Asp Arg Glu Phe Val Phe Leu Gln Lys Tyr Pro His Val Glu 
    610                 615                 620                 


Pro His Thr His Leu Val His Gln Ala Asn Val Leu Leu Ala Leu Gln 
625                 630                 635                 640 


Leu Leu Leu Glu Asp Arg Glu Phe Val Phe Leu Gln Lys Tyr Pro His 
                645                 650                 655     


Val Glu Pro His Thr His Leu Val His Gln Ala Asn Val Leu Leu Ala 
            660                 665                 670         


Leu Gln Leu Leu Leu Glu Asp Arg Glu Phe Val Phe Leu Gln Lys Tyr 
        675                 680                 685             


Pro His Val Glu Pro His Thr His Leu Val His Gln Ala Asn Val Leu 
    690                 695                 700                 


Leu Ala Leu Gln Leu Leu Leu Glu Asp Arg Glu Phe Val Phe Leu Gln 
705                 710                 715                 720 


Lys Tyr Pro His Val Glu Pro His Thr His Leu Val His Gln Ala Asn 
                725                 730                 735     


Val Leu Leu Ala Leu Gln Leu Leu Leu Glu Asp Arg Glu Phe Val Phe 
            740                 745                 750         


Leu Gln Lys Tyr Pro His Val Glu His His His His His His 
        755                 760                 765     


<210>  51
<211>  761
<212>  PRT
<213>  Artificial sequence

<220>
<223>  fusion biogenic polypeptide

<400>  51

Met Ala Glu Gln Leu Val Asp Leu Trp Asn Glu Cys Ala Lys Ala Cys 
1               5                   10                  15      


Val Leu Asp Leu Lys Asp Gly Val Arg Ser Ser Arg Met Ser Val Asp 
            20                  25                  30          


Pro Ala Ile Ala Asp Thr Asn Gly Gln Gly Val Leu His Tyr Cys Met 
        35                  40                  45              


Glu Phe Ser Thr Pro Phe His Pro Leu Pro Ala Arg Lys Pro Leu Pro 
    50                  55                  60                  


Leu Val Pro Leu Glu His Met Ala Glu Glu Ala Phe Asp Leu Trp Asn 
65                  70                  75                  80  


Glu Cys Ala Lys Ala Cys Val Leu Asp Leu Lys Asp Gly Val Arg Ser 
                85                  90                  95      


Ser Arg Met Ser Val Asp Pro Ala Ile Ala Asp Thr Asn Gly Gln Gly 
            100                 105                 110         


Val Leu His Tyr Ser Met Val Leu Glu Gly Gly Asn Asp Ala Leu Lys 
        115                 120                 125             


Leu Ala Ile Asp Asn Ala Leu Ser Ile Thr Ser Asp Gly Leu Thr Ile 
    130                 135                 140                 


Arg Leu Glu Gly Gly Val Glu Pro Asn Lys Pro Val Arg Tyr Ser Tyr 
145                 150                 155                 160 


Thr Arg Gln Ala Arg Gly Ser Trp Ser Leu Asn Trp Leu Val Pro Ile 
                165                 170                 175     


Gly His Glu Lys Pro Ser Asn Ile Lys Val Phe Ile His Glu Leu Asn 
            180                 185                 190         


Ala Gly Asn Gln Leu Ser His Met Ser Pro Ile Tyr Thr Ile Glu Met 
        195                 200                 205             


Gly Asp Glu Leu Leu Ala Lys Leu Ala Arg Asp Ala Thr Phe Phe Val 
    210                 215                 220                 


Arg Ala His Glu Ser Asn Glu Met Gln Pro Thr Leu Ala Ile Ser His 
225                 230                 235                 240 


Ala Gly Val Ser Val Val Met Ala Gln Thr Gln Pro Arg Arg Glu Lys 
                245                 250                 255     


Arg Trp Ser Glu Trp Ala Ser Gly Lys Val Leu Cys Leu Leu Asp Pro 
            260                 265                 270         


Leu Asp Gly Val Tyr Asn Tyr Leu Ala Gln Gln Arg Cys Asn Leu Asp 
        275                 280                 285             


Asp Thr Trp Glu Gly Lys Ile Tyr Arg Val Leu Ala Gly Asn Pro Ala 
    290                 295                 300                 


Lys His Asp Leu Asp Ile Lys Pro Thr Val Ile Ser His Arg Leu His 
305                 310                 315                 320 


Phe Pro Glu Gly Gly Ser Leu Ala Ala Leu Thr Ala His Gln Ala Cys 
                325                 330                 335     


His Leu Pro Leu Glu Thr Phe Thr Arg His Arg Gln Pro Arg Gly Trp 
            340                 345                 350         


Glu Gln Leu Glu Gln Cys Gly Tyr Pro Val Gln Arg Leu Val Ala Leu 
        355                 360                 365             


Tyr Leu Ala Ala Arg Leu Ser Trp Asn Gln Val Asp Gln Val Ile Arg 
    370                 375                 380                 


Asn Ala Leu Ala Ser Pro Gly Ser Gly Gly Asp Leu Gly Glu Ala Ile 
385                 390                 395                 400 


Arg Glu Gln Pro Glu Gln Ala Arg Leu Ala Leu Thr Leu Ala Ala Ala 
                405                 410                 415     


Glu Ser Glu Arg Phe Val Arg Gln Gly Thr Gly Asn Asp Glu Ala Gly 
            420                 425                 430         


Ala Ala Asn Ala Asp Val Val Ser Leu Thr Cys Pro Val Ala Ala Gly 
        435                 440                 445             


Glu Cys Ala Gly Pro Ala Asp Ser Gly Asp Ala Leu Leu Glu Arg Asn 
    450                 455                 460                 


Tyr Pro Thr Gly Ala Glu Phe Leu Gly Asp Gly Gly Asp Val Glu Phe 
465                 470                 475                 480 


Leu Leu Glu Pro His Thr His Leu Val His Gln Ala Asn Val Leu Leu 
                485                 490                 495     


Ala Leu Gln Leu Leu Leu Glu Asp Arg Glu Phe Val Phe Leu Gln Lys 
            500                 505                 510         


Tyr Pro His Val Glu Pro His Thr His Leu Val His Gln Ala Asn Val 
        515                 520                 525             


Leu Leu Ala Leu Gln Leu Leu Leu Glu Asp Arg Glu Phe Val Phe Leu 
    530                 535                 540                 


Gln Lys Tyr Pro His Val Glu Pro His Thr His Leu Val His Gln Ala 
545                 550                 555                 560 


Asn Val Leu Leu Ala Leu Gln Leu Leu Leu Glu Asp Arg Glu Phe Val 
                565                 570                 575     


Phe Leu Gln Lys Tyr Pro His Val Glu Pro His Thr His Leu Val His 
            580                 585                 590         


Gln Ala Asn Val Leu Leu Ala Leu Gln Leu Leu Leu Glu Asp Arg Glu 
        595                 600                 605             


Phe Val Phe Leu Gln Lys Tyr Pro His Val Glu Pro His Thr His Leu 
    610                 615                 620                 


Val His Gln Ala Asn Val Leu Leu Ala Leu Gln Leu Leu Leu Glu Asp 
625                 630                 635                 640 


Arg Glu Phe Val Phe Leu Gln Lys Tyr Pro His Val Glu Pro His Thr 
                645                 650                 655     


His Leu Val His Gln Ala Asn Val Leu Leu Ala Leu Gln Leu Leu Leu 
            660                 665                 670         


Glu Asp Arg Glu Phe Val Phe Leu Gln Lys Tyr Pro His Val Glu Pro 
        675                 680                 685             


His Thr His Leu Val His Gln Ala Asn Val Leu Leu Ala Leu Gln Leu 
    690                 695                 700                 


Leu Leu Glu Asp Arg Glu Phe Val Phe Leu Gln Lys Tyr Pro His Val 
705                 710                 715                 720 


Glu Pro His Thr His Leu Val His Gln Ala Asn Val Leu Leu Ala Leu 
                725                 730                 735     


Gln Leu Leu Leu Glu Asp Arg Glu Phe Val Phe Leu Gln Lys Tyr Pro 
            740                 745                 750         


His Val Glu His His His His His His 
        755                 760     


<210>  52
<211>  804
<212>  PRT
<213>  Artificial sequence

<220>
<223>  fusion biogenic polypeptide

<400>  52

Met Ala Glu Gln Leu Val Asp Leu Trp Asn Glu Cys Ala Lys Ala Cys 
1               5                   10                  15      


Val Leu Asp Leu Lys Asp Gly Val Arg Ser Ser Arg Met Ser Val Asp 
            20                  25                  30          


Pro Ala Ile Ala Asp Thr Asn Gly Gln Gly Val Leu His Tyr Cys Met 
        35                  40                  45              


Glu Phe Ser Ser Phe His Leu Phe His His Leu Pro Ala Arg Ala Pro 
    50                  55                  60                  


Leu Ala Pro Ser Glu Leu Gln Pro Leu Glu His Met Ala Glu Glu Ala 
65                  70                  75                  80  


Phe Asp Leu Trp Asn Glu Cys Ala Lys Ala Cys Val Leu Asp Leu Lys 
                85                  90                  95      


Asp Gly Val Arg Ser Ser Arg Met Ser Val Asp Pro Ala Ile Ala Asp 
            100                 105                 110         


Thr Asn Gly Gln Gly Val Leu His Tyr Ser Met Val Leu Glu Gly Gly 
        115                 120                 125             


Asn Asp Ala Leu Lys Leu Ala Ile Asp Asn Ala Leu Ser Ile Thr Ser 
    130                 135                 140                 


Asp Gly Leu Thr Ile Arg Leu Glu Gly Gly Val Glu Pro Asn Lys Pro 
145                 150                 155                 160 


Val Arg Tyr Ser Tyr Thr Arg Gln Ala Arg Gly Ser Trp Ser Leu Asn 
                165                 170                 175     


Trp Leu Val Pro Ile Gly His Glu Lys Pro Ser Asn Ile Lys Val Phe 
            180                 185                 190         


Ile His Glu Leu Asn Ala Gly Asn Gln Leu Ser His Met Ser Pro Ile 
        195                 200                 205             


Tyr Thr Ile Glu Met Gly Asp Glu Leu Leu Ala Lys Leu Ala Arg Asp 
    210                 215                 220                 


Ala Thr Phe Phe Val Arg Ala His Glu Ser Asn Glu Met Gln Pro Thr 
225                 230                 235                 240 


Leu Ala Ile Ser His Ala Gly Val Ser Val Val Met Ala Gln Thr Gln 
                245                 250                 255     


Pro Arg Arg Glu Lys Arg Trp Ser Glu Trp Ala Ser Gly Lys Val Leu 
            260                 265                 270         


Cys Leu Leu Asp Pro Leu Asp Gly Val Tyr Asn Tyr Leu Ala Gln Gln 
        275                 280                 285             


Arg Cys Asn Leu Asp Asp Thr Trp Glu Gly Lys Ile Tyr Arg Val Leu 
    290                 295                 300                 


Ala Gly Asn Pro Ala Lys His Asp Leu Asp Ile Lys Pro Thr Val Ile 
305                 310                 315                 320 


Ser His Arg Leu His Phe Pro Glu Gly Gly Ser Leu Ala Ala Leu Thr 
                325                 330                 335     


Ala His Gln Ala Cys His Leu Pro Leu Glu Thr Phe Thr Arg His Arg 
            340                 345                 350         


Gln Pro Arg Gly Trp Glu Gln Leu Glu Gln Cys Gly Tyr Pro Val Gln 
        355                 360                 365             


Arg Leu Val Ala Leu Tyr Leu Ala Ala Arg Leu Ser Trp Asn Gln Val 
    370                 375                 380                 


Asp Gln Val Ile Arg Asn Ala Leu Ala Ser Pro Gly Ser Gly Gly Asp 
385                 390                 395                 400 


Leu Gly Glu Ala Ile Arg Glu Gln Pro Glu Gln Ala Arg Leu Ala Leu 
                405                 410                 415     


Thr Leu Ala Ala Ala Glu Ser Glu Arg Phe Val Arg Gln Gly Thr Gly 
            420                 425                 430         


Asn Asp Glu Ala Gly Ala Ala Asn Ala Asp Val Val Ser Leu Thr Cys 
        435                 440                 445             


Pro Val Ala Ala Gly Glu Cys Ala Gly Pro Ala Asp Ser Gly Asp Ala 
    450                 455                 460                 


Leu Leu Glu Arg Asn Tyr Pro Thr Gly Ala Glu Phe Leu Gly Asp Gly 
465                 470                 475                 480 


Gly Asp Val Ser Phe Ser Thr Arg Gly Thr Gln Asn Trp Thr Val Glu 
                485                 490                 495     


Arg Leu Leu Gln Ala Glu Phe Val Ser Phe Ser Thr Gly Gly Ser Gln 
            500                 505                 510         


Asn Trp Thr Val Glu Arg Leu Leu Gln Ala Glu Phe Cys Ser Thr Ser 
        515                 520                 525             


Gln Ala Ala Arg Gln Arg Leu Glu Thr Gly Arg Asn Cys Ser Thr Gly 
    530                 535                 540                 


Gln Ala Ala Arg Gln Arg Leu Glu Pro Gly Arg Asn Leu Val Leu Cys 
545                 550                 555                 560 


Leu Thr Ser Gln Ala Ala Gln Gln Arg Leu Glu Pro Gly Gly Asn Cys 
                565                 570                 575     


Gln Thr Ser Gln Ala Ala His Gln Arg Leu Glu Pro Gly Arg Asn Cys 
            580                 585                 590         


Arg Thr Ser Gln Ala Ala Ser Gln Arg Leu Glu Pro Gly Arg Asn Cys 
        595                 600                 605             


Arg Thr Ser Gln Ala Ala His Gln Arg Leu Glu Pro Gly Arg Asn Cys 
    610                 615                 620                 


Ser Thr Arg Gln Ala Ala Gln Gln Arg Leu Glu Pro Gly Arg Asn Leu 
625                 630                 635                 640 


Leu Cys Pro Thr Ser Gln Ala Ala His Gln Arg Arg Leu Glu Pro Gly 
                645                 650                 655     


Arg Asn Cys Ser Thr Ser Gln Ala Ala Tyr Gln Arg Leu Glu Pro Gly 
            660                 665                 670         


Arg Asn Cys Pro Thr Ser Arg Ala Ala Arg Gln Arg Leu Glu Pro Gly 
        675                 680                 685             


Arg Asn Leu Leu Cys Ser Thr Ser Gln Ala Ala Leu Gln Arg Leu Glu 
    690                 695                 700                 


Pro Gly Arg Asn Leu Cys Pro Thr Ser Gln Ala Ala Lys Gln Arg Leu 
705                 710                 715                 720 


Glu Pro Gly Arg Asn Leu Val Val Cys Leu Thr Ser Gln Ala Ala Arg 
                725                 730                 735     


Gln Arg Leu Glu Pro Gly Arg Asn Cys Ser Thr Ser Gln Ala Ala Ser 
            740                 745                 750         


Gln Arg Leu Glu Pro Gly Arg Asn Cys Pro Thr Ser Gln Ala Ala Arg 
        755                 760                 765             


Gln Arg Leu Glu Pro Gly Arg Asn Val Leu Leu Leu Cys Leu Thr Ser 
    770                 775                 780                 


Gln Ala Ala His Gln Arg Leu Glu Pro Gly Arg Asn Leu Glu His His 
785                 790                 795                 800 


His His His His 
                


<210>  53
<211>  737
<212>  PRT
<213>  Artificial sequence

<220>
<223>  fusion biogenic polypeptide

<400>  53

Met Ala Glu Gln Leu Val Asp Leu Trp Asn Glu Cys Ala Lys Ala Cys 
1               5                   10                  15      


Val Leu Asp Leu Lys Asp Gly Val Arg Ser Ser Arg Met Ser Val Asp 
            20                  25                  30          


Pro Ala Ile Ala Asp Thr Asn Gly Gln Gly Val Leu His Tyr Cys Met 
        35                  40                  45              


Glu Phe Ser Ser Phe His Leu Phe His His Leu Pro Ala Arg Ala Pro 
    50                  55                  60                  


Leu Ala Pro Ser Glu Leu Gln Pro Leu Glu His Met Ala Glu Glu Ala 
65                  70                  75                  80  


Phe Asp Leu Trp Asn Glu Cys Ala Lys Ala Cys Val Leu Asp Leu Lys 
                85                  90                  95      


Asp Gly Val Arg Ser Ser Arg Met Ser Val Asp Pro Ala Ile Ala Asp 
            100                 105                 110         


Thr Asn Gly Gln Gly Val Leu His Tyr Ser Met Val Leu Glu Gly Gly 
        115                 120                 125             


Asn Asp Ala Leu Lys Leu Ala Ile Asp Asn Ala Leu Ser Ile Thr Ser 
    130                 135                 140                 


Asp Gly Leu Thr Ile Arg Leu Glu Gly Gly Val Glu Pro Asn Lys Pro 
145                 150                 155                 160 


Val Arg Tyr Ser Tyr Thr Arg Gln Ala Arg Gly Ser Trp Ser Leu Asn 
                165                 170                 175     


Trp Leu Val Pro Ile Gly His Glu Lys Pro Ser Asn Ile Lys Val Phe 
            180                 185                 190         


Ile His Glu Leu Asn Ala Gly Asn Gln Leu Ser His Met Ser Pro Ile 
        195                 200                 205             


Tyr Thr Ile Glu Met Gly Asp Glu Leu Leu Ala Lys Leu Ala Arg Asp 
    210                 215                 220                 


Ala Thr Phe Phe Val Arg Ala His Glu Ser Asn Glu Met Gln Pro Thr 
225                 230                 235                 240 


Leu Ala Ile Ser His Ala Gly Val Ser Val Val Met Ala Gln Thr Gln 
                245                 250                 255     


Pro Arg Arg Glu Lys Arg Trp Ser Glu Trp Ala Ser Gly Lys Val Leu 
            260                 265                 270         


Cys Leu Leu Asp Pro Leu Asp Gly Val Tyr Asn Tyr Leu Ala Gln Gln 
        275                 280                 285             


Arg Cys Asn Leu Asp Asp Thr Trp Glu Gly Lys Ile Tyr Arg Val Leu 
    290                 295                 300                 


Ala Gly Asn Pro Ala Lys His Asp Leu Asp Ile Lys Pro Thr Val Ile 
305                 310                 315                 320 


Ser His Arg Leu His Phe Pro Glu Gly Gly Ser Leu Ala Ala Leu Thr 
                325                 330                 335     


Ala His Gln Ala Cys His Leu Pro Leu Glu Thr Phe Thr Arg His Arg 
            340                 345                 350         


Gln Pro Arg Gly Trp Glu Gln Leu Glu Gln Cys Gly Tyr Pro Val Gln 
        355                 360                 365             


Arg Leu Val Ala Leu Tyr Leu Ala Ala Arg Leu Ser Trp Asn Gln Val 
    370                 375                 380                 


Asp Gln Val Ile Arg Asn Ala Leu Ala Ser Pro Gly Ser Gly Gly Asp 
385                 390                 395                 400 


Leu Gly Glu Ala Ile Arg Glu Gln Pro Glu Gln Ala Arg Leu Ala Leu 
                405                 410                 415     


Thr Leu Ala Ala Ala Glu Ser Glu Arg Phe Val Arg Gln Gly Thr Gly 
            420                 425                 430         


Asn Asp Glu Ala Gly Ala Ala Asn Ala Asp Val Val Ser Leu Thr Cys 
        435                 440                 445             


Pro Val Ala Ala Gly Glu Cys Ala Gly Pro Ala Asp Ser Gly Asp Ala 
    450                 455                 460                 


Leu Leu Glu Arg Asn Tyr Pro Thr Gly Ala Glu Phe Leu Gly Asp Gly 
465                 470                 475                 480 


Gly Asp Val Ser Phe Ser Thr Arg Gly Thr Gln Asn Trp Thr Val Glu 
                485                 490                 495     


Arg Leu Leu Gln Ala Glu Phe Gly Val Ser Ala Ala Gln Glu Lys Ile 
            500                 505                 510         


Ser Phe Gly Leu Leu Gly Val Pro Thr Ala Gln Glu Thr Thr Ser Ile 
        515                 520                 525             


Arg Glu Val Leu Glu Val Ser Thr Ala Gln Glu Asn Ser Pro Phe Met 
    530                 535                 540                 


Leu Gly Ala Ser Ala Thr Glu Glu Lys Thr Ser Leu Arg Leu Gly Ala 
545                 550                 555                 560 


Ser Thr Thr Gln Glu Thr Ser Phe Gly Lys Cys Leu Arg Pro His Gly 
                565                 570                 575     


Val Ser Ala Ala Gln Gly Thr Thr Pro Phe Arg Gly Val Ser Thr Thr 
            580                 585                 590         


Gln Glu Asn Thr Ser Phe Gly Arg Val Pro Thr Ala Gln Glu Asn Val 
        595                 600                 605             


Ser Phe Gly Leu His Gly Val Pro Ala Ala Gln Lys Thr Asn Ser Phe 
    610                 615                 620                 


Gly Gly Val Pro Thr Ala Gln Glu Asn Ile Ser Phe Lys Glu Val Ser 
625                 630                 635                 640 


Ala Thr Gln Arg Glu Ile Pro Phe Arg Cys Leu Arg Pro His Gly Val 
                645                 650                 655     


Ser Thr Ala Gln Glu Thr Pro Phe Arg Gly Val Ser Thr Ala Gln Glu 
            660                 665                 670         


Thr Ile Pro Phe Arg Gly Val Ser Ala Thr His Glu Asn Ile Ser Phe 
        675                 680                 685             


Gly Cys Leu Arg Pro His Gly Val Ser Ala Ala Gln Glu Ser Ile Pro 
    690                 695                 700                 


Ile Arg Leu Gly Ala Ser Ala Ala Gln Glu Asn Thr Ser Phe Arg Gly 
705                 710                 715                 720 


Thr Pro Ala Ala Gln Glu Lys Ile Pro Leu Glu His His His His His 
                725                 730                 735     


His 
    


<210>  54
<211>  796
<212>  PRT
<213>  Artificial sequence

<220>
<223>  fusion biogenic polypeptide

<400>  54

Met Ala Glu Gln Leu Val Asp Leu Trp Asn Glu Cys Ala Lys Ala Cys 
1               5                   10                  15      


Val Leu Asp Leu Lys Asp Gly Val Arg Ser Ser Arg Met Ser Val Asp 
            20                  25                  30          


Pro Ala Ile Ala Asp Thr Asn Gly Gln Gly Val Leu His Tyr Cys Met 
        35                  40                  45              


Glu Phe Ser Ser Phe His Leu Phe His His Leu Pro Ala Arg Ala Pro 
    50                  55                  60                  


Leu Ala Pro Ser Glu Leu Gln Pro Leu Glu His Met Ala Glu Glu Ala 
65                  70                  75                  80  


Phe Asp Leu Trp Asn Glu Cys Ala Lys Ala Cys Val Leu Asp Leu Lys 
                85                  90                  95      


Asp Gly Val Arg Ser Ser Arg Met Ser Val Asp Pro Ala Ile Ala Asp 
            100                 105                 110         


Thr Asn Gly Gln Gly Val Leu His Tyr Ser Met Val Leu Glu Gly Gly 
        115                 120                 125             


Asn Asp Ala Leu Lys Leu Ala Ile Asp Asn Ala Leu Ser Ile Thr Ser 
    130                 135                 140                 


Asp Gly Leu Thr Ile Arg Leu Glu Gly Gly Val Glu Pro Asn Lys Pro 
145                 150                 155                 160 


Val Arg Tyr Ser Tyr Thr Arg Gln Ala Arg Gly Ser Trp Ser Leu Asn 
                165                 170                 175     


Trp Leu Val Pro Ile Gly His Glu Lys Pro Ser Asn Ile Lys Val Phe 
            180                 185                 190         


Ile His Glu Leu Asn Ala Gly Asn Gln Leu Ser His Met Ser Pro Ile 
        195                 200                 205             


Tyr Thr Ile Glu Met Gly Asp Glu Leu Leu Ala Lys Leu Ala Arg Asp 
    210                 215                 220                 


Ala Thr Phe Phe Val Arg Ala His Glu Ser Asn Glu Met Gln Pro Thr 
225                 230                 235                 240 


Leu Ala Ile Ser His Ala Gly Val Ser Val Val Met Ala Gln Thr Gln 
                245                 250                 255     


Pro Arg Arg Glu Lys Arg Trp Ser Glu Trp Ala Ser Gly Lys Val Leu 
            260                 265                 270         


Cys Leu Leu Asp Pro Leu Asp Gly Val Tyr Asn Tyr Leu Ala Gln Gln 
        275                 280                 285             


Arg Cys Asn Leu Asp Asp Thr Trp Glu Gly Lys Ile Tyr Arg Val Leu 
    290                 295                 300                 


Ala Gly Asn Pro Ala Lys His Asp Leu Asp Ile Lys Pro Thr Val Ile 
305                 310                 315                 320 


Ser His Arg Leu His Phe Pro Glu Gly Gly Ser Leu Ala Ala Leu Thr 
                325                 330                 335     


Ala His Gln Ala Cys His Leu Pro Leu Glu Thr Phe Thr Arg His Arg 
            340                 345                 350         


Gln Pro Arg Gly Trp Glu Gln Leu Glu Gln Cys Gly Tyr Pro Val Gln 
        355                 360                 365             


Arg Leu Val Ala Leu Tyr Leu Ala Ala Arg Leu Ser Trp Asn Gln Val 
    370                 375                 380                 


Asp Gln Val Ile Arg Asn Ala Leu Ala Ser Pro Gly Ser Gly Gly Asp 
385                 390                 395                 400 


Leu Gly Glu Ala Ile Arg Glu Gln Pro Glu Gln Ala Arg Leu Ala Leu 
                405                 410                 415     


Thr Leu Ala Ala Ala Glu Ser Glu Arg Phe Val Arg Gln Gly Thr Gly 
            420                 425                 430         


Asn Asp Glu Ala Gly Ala Ala Asn Ala Asp Val Val Ser Leu Thr Cys 
        435                 440                 445             


Pro Val Ala Ala Gly Glu Cys Ala Gly Pro Ala Asp Ser Gly Asp Ala 
    450                 455                 460                 


Leu Leu Glu Arg Asn Tyr Pro Thr Gly Ala Glu Phe Leu Gly Asp Gly 
465                 470                 475                 480 


Gly Asp Val Ser Phe Ser Thr Arg Gly Thr Gln Asn Trp Thr Val Glu 
                485                 490                 495     


Arg Leu Leu Gln Ala Glu Phe Leu Gly Val Ser Ala Ala Gln Glu Arg 
            500                 505                 510         


Ile Pro Ile Arg Glu Val Ser Ala Asp Lys Glu Val Ser Ala Glu Lys 
        515                 520                 525             


Lys Glu Ile Ser Phe Gly Val Ser Thr Ala Gln Gly Asn Ile Ser Phe 
    530                 535                 540                 


Gly Leu Gly Val Ser Thr Ala Gln Glu Ala Ile Pro Phe Leu Ala Leu 
545                 550                 555                 560 


Gly Val Ser Thr Ala Gln Glu Thr Ile Pro Phe Gly Leu Leu Gly Val 
                565                 570                 575     


Ser Thr Ala Gln Gly Ile Ile Ser Phe Gly Gly Val Ser Thr Ala Gln 
            580                 585                 590         


Glu Asn Ile Ser Phe Gly Gly Val Ser Thr Ala Gln Glu Thr Ile Ser 
        595                 600                 605             


Phe Gly Leu Leu Gly Val Ser Thr Ala Gln Glu Asn Ile Ser Phe Gly 
    610                 615                 620                 


Cys Leu Arg Thr His Glu Val Ser Ala Ala Gln Glu Lys Ile Ser Phe 
625                 630                 635                 640 


Gly Gly Val Ser Glu Ala Gln Lys Ile Ser Phe Gly Val Ser Ala Ala 
                645                 650                 655     


Gly Val Ser Ala Ala Gln Glu Glu Ile Pro Phe Gly Cys Leu Arg Pro 
            660                 665                 670         


His Gly Leu Pro Ala Ala Gln Glu Lys Thr Ser Phe Gly Gly Val Ser 
        675                 680                 685             


Ala Ala Gln Glu Lys Thr Ser Phe Gly Gly Val Ser Ala Ala Gln Glu 
    690                 695                 700                 


Glu Phe Ser Phe Gly Cys Leu Arg Pro His Arg Val Ser Ala Ala Gln 
705                 710                 715                 720 


Glu Lys Ile Ser Phe Glu Val Ser Ala Leu Glu Val Ser Ala Ala Gln 
                725                 730                 735     


Glu Lys Ile Ser Phe Gly Val Ser Ala Ala Leu Gly Val Ser Ala Ala 
            740                 745                 750         


Gln Glu Lys Asn Ser Phe Gly Cys Leu Arg Pro His Gly Val Ser Ala 
        755                 760                 765             


Ala Gln Glu Lys Thr Ser Phe Gly Gly Val Ser Ala Ala Gln Lys Lys 
    770                 775                 780                 


Ile Ser Phe Gly Leu Glu His His His His His His 
785                 790                 795     


<210>  55
<211>  48
<212>  DNA
<213>  Artificial sequence

<220>
<223>  primer

<400>  55
gttgacccgg ttggtccgtc cgacccgtcc atcgtttccc tggttgaa                    48


<210>  56
<211>  49
<212>  DNA
<213>  Artificial sequence

<220>
<223>  primer

<400>  56
aggtcggagc accagcgtcg atgaaggagg tttcttcaac cagggaaac                   49


<210>  57
<211>  48
<212>  DNA
<213>  Artificial sequence

<220>
<223>  primer

<400>  57
gacaccctgg ctccggttcg tccgccgctg accgttgacc cggttggt                    48


<210>  58
<211>  48
<212>  DNA
<213>  Artificial sequence

<220>
<223>  primer

<400>  58
accggaaacg tccggcggga tggacggaac ggaggtcgga gcaccagc                    48


<210>  59
<211>  51
<212>  DNA
<213>  Artificial sequence

<220>
<223>  primer

<400>  59
tacatcccgc tgggtacccg tccgccgacc gctaccgaca ccctggctcc g                51


<210>  60
<211>  51
<212>  DNA
<213>  Artificial sequence

<220>
<223>  primer

<400>  60
agccggggta gtgtcggtgg aggtggtgat ggagaaaccg gaaacgtccg g                51


<210>  61
<211>  48
<212>  DNA
<213>  Artificial sequence

<220>
<223>  primer

<400>  61
ggtaccggtt ccggtactgg cggtcgtacc ggttacatcc cgctgggt                    48


<210>  62
<211>  51
<212>  DNA
<213>  Artificial sequence

<220>
<223>  primer

<400>  62
tacggtagta acggtgttgt tgttgatgtc caggatagcc ggggtagtgt c                51


<210>  63
<211>  51
<212>  DNA
<213>  Artificial sequence

<220>
<223>  primer

<400>  63
ggttctatgg gtgttttctt cggcggtctg ggcatcggta ccggttccgg t                51


<210>  64
<211>  48
<212>  DNA
<213>  Artificial sequence

<220>
<223>  primer

<400>  64
cgggtcggtg aaggtcgggt tgttgtgagt ggttacggta gtaacggt                    48


<210>  65
<211>  48
<212>  DNA
<213>  Artificial sequence

<220>
<223>  primer

<400>  65
ggtaaaacca tcgctgaaca gatcctgcaa tacggttcta tgggtgtt                    48


<210>  66
<211>  48
<212>  DNA
<213>  Artificial sequence

<220>
<223>  primer

<400>  66
ggtttcagcc ggggtcggcg gttgcagaac ggacgggtcg gtgaaggt                    48


<210>  67
<211>  51
<212>  DNA
<213>  Artificial sequence

<220>
<223>  primer

<400>  67
ggtacctgcc cgccggacat catcccgaaa gttgaaggta aaaccatcgc t                51


<210>  68
<211>  51
<212>  DNA
<213>  Artificial sequence

<220>
<223>  primer

<400>  68
ggagatggtg gaagaggaca gggtgaagtg accaccggtt tcagccgggg t                51


<210>  69
<211>  45
<212>  DNA
<213>  Artificial sequence

<220>
<223>  primer

<400>  69
acccagctgt acaaaacctg caaacaggct ggtacctgcc cgccg                       45


<210>  70
<211>  45
<212>  DNA
<213>  Artificial sequence

<220>
<223>  primer

<400>  70
gtccatcggg atttcttcgt agttgtgggt ggagatggtg gaaga                       45


<210>  71
<211>  47
<212>  DNA
<213>  Artificial sequence

<220>
<223>  primer

<400>  71
ccgtgctaaa cgtcgtaaac gtgcttccgc tacccagctg tacaaaa                     47


<210>  72
<211>  48
<212>  DNA
<213>  Artificial sequence

<220>
<223>  primer

<400>  72
attatttttc tcgagcagtt cgtctttggt gtccatcggg atttcttc                    48


<210>  73
<211>  48
<212>  DNA
<213>  Artificial sequence

<220>
<223>  primer

<400>  73
cccgaattcc atatggtcga cggtatgtcc atccgtgcta aacgtcgt                    48


<210>  74
<211>  48
<212>  DNA
<213>  Artificial sequence

<220>
<223>  primer

<400>  74
attatttttc tcgagcagtt cgtctttggt gtccatcggg atttcttc                    48


<210>  75
<211>  21
<212>  DNA
<213>  Artificial sequence

<220>
<223>  primer

<400>  75
ccccatatgg ccgaagaagc t                                                 21


<210>  76
<211>  49
<212>  DNA
<213>  Artificial sequence

<220>
<223>  primer

<400>  76
tttctcgagt tgaattccat ggagtagttc atcactccct ggccgttgg                   49


<210>  77
<211>  21
<212>  DNA
<213>  Artificial sequence

<220>
<223>  primer

<400>  77
ccccatatgg ccgaagaagc t                                                 21


<210>  78
<211>  44
<212>  DNA
<213>  Artificial sequence

<220>
<223>  primer

<400>  78
tttctcgagg aattcgacgt cgccgccgtc gccgaggaac tccg                        44


<210>  79
<211>  21
<212>  DNA
<213>  Artificial sequence

<220>
<223>  primer

<400>  79
ccccatatgg ccgaagaagc t                                                 21


<210>  80
<211>  38
<212>  DNA
<213>  Artificial sequence

<220>
<223>  primer

<400>  80
tttctcgagg aattccgcct ggagcagccg ctccaccg                               38


<210>  81
<211>  30
<212>  DNA
<213>  Artificial sequence

<220>
<223>  primer

<400>  81
tataccatgg ccgaacaatt ggtggacctc                                        30


<210>  82
<211>  40
<212>  DNA
<213>  Artificial sequence

<220>
<223>  primer

<400>  82
tttctcgagg aattcttcca tgcagtagtg cagcacgccc                             40


