                         SEQUENCE LISTING

<110>  ELI LILLY AND COMPANY
 
<120>  ANTI-RANKL ANTIBODIES AND USES THEREOF

<130>  X21259

<150>  62/414,217
<151>  2016-10-28

<160>  17    

<170>  PatentIn version 3.5

<210>  1
<211>  447
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exemplified HC

<400>  1

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Ala Phe Thr Asn Tyr 
            20                  25                  30          


Tyr Ile Glu Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Val Ile Asn Pro Gly Trp Gly Asp Thr Asn Tyr Asn Glu Lys Phe 
    50                  55                  60                  


Lys Gly Arg Val Thr Ile Thr Ala Asp Lys Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Arg Asp Thr Ala His Gly Tyr Tyr Ala Leu Asp Pro Trp Gly 
            100                 105                 110         


Gln Gly Thr Thr Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser 
        115                 120                 125             


Val Phe Pro Leu Ala Pro Cys Ser Arg Ser Thr Ser Glu Ser Thr Ala 
    130                 135                 140                 


Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val 
145                 150                 155                 160 


Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala 
                165                 170                 175     


Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val 
            180                 185                 190         


Pro Ser Ser Ser Leu Gly Thr Lys Thr Tyr Thr Cys Asn Val Asp His 
        195                 200                 205             


Lys Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu Ser Lys Tyr Gly 
    210                 215                 220                 


Pro Pro Cys Pro Pro Cys Pro Ala Pro Glu Ala Ala Gly Gly Pro Ser 
225                 230                 235                 240 


Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg 
                245                 250                 255     


Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser Gln Glu Asp Pro 
            260                 265                 270         


Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala 
        275                 280                 285             


Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val 
    290                 295                 300                 


Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr 
305                 310                 315                 320 


Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr 
                325                 330                 335     


Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu 
            340                 345                 350         


Pro Pro Ser Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys 
        355                 360                 365             


Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser 
    370                 375                 380                 


Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp 
385                 390                 395                 400 


Ser Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser 
                405                 410                 415     


Arg Trp Gln Glu Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala 
            420                 425                 430         


Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly 
        435                 440                 445         


<210>  2
<211>  214
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exemplified LC

<400>  2

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Lys Ala Ser Gln Asn Val Gly Thr Asn 
            20                  25                  30          


Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ser Ala Ser Tyr Arg Tyr Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Trp Asp Tyr Pro Leu 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala Ala 
            100                 105                 110         


Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             


Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 


Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 


Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     


Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         


Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             


Phe Asn Arg Gly Glu Cys 
    210                 


<210>  3
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exemplified HCVR

<400>  3

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Ala Phe Thr Asn Tyr 
            20                  25                  30          


Tyr Ile Glu Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Val Ile Asn Pro Gly Trp Gly Asp Thr Asn Tyr Asn Glu Lys Phe 
    50                  55                  60                  


Lys Gly Arg Val Thr Ile Thr Ala Asp Lys Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Arg Asp Thr Ala His Gly Tyr Tyr Ala Leu Asp Pro Trp Gly 
            100                 105                 110         


Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120     


<210>  4
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exemplified LCVR

<400>  4

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Lys Ala Ser Gln Asn Val Gly Thr Asn 
            20                  25                  30          


Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ser Ala Ser Tyr Arg Tyr Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Trp Asp Tyr Pro Leu 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  5
<211>  446
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exemplified HC

<400>  5

Gln Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Val Arg Pro Gly Thr 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Ala Phe Thr Asn Tyr 
            20                  25                  30          


Tyr Ile Glu Trp Leu Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Val Ile Asn Pro Gly Trp Gly Asp Thr Asn Tyr Asn Glu Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Ala Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Gln Leu Ser Ser Leu Thr Ser Asp Asp Ser Ala Val Phe Phe Cys 
                85                  90                  95      


Ala Arg Arg Asp Thr Arg His Gly Tyr Tyr Ala Leu Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Ser Val Thr Val Ser Ser Ala Lys Thr Thr Pro Pro Ser 
        115                 120                 125             


Val Tyr Pro Leu Ala Pro Gly Thr Ala Leu Lys Ser Asn Ser Met Val 
    130                 135                 140                 


Thr Leu Gly Cys Leu Val Lys Gly Tyr Phe Pro Glu Pro Val Thr Val 
145                 150                 155                 160 


Thr Trp Asn Ser Gly Ala Leu Ser Ser Gly Val His Thr Phe Pro Ala 
                165                 170                 175     


Val Leu Gln Ser Gly Leu Tyr Thr Leu Thr Ser Ser Val Thr Val Pro 
            180                 185                 190         


Ser Ser Thr Trp Pro Ser Gln Thr Val Thr Cys Asn Val Ala His Pro 
        195                 200                 205             


Ala Ser Ser Thr Lys Val Asp Lys Lys Ile Val Pro Arg Asn Cys Gly 
    210                 215                 220                 


Gly Asp Cys Lys Pro Cys Ile Cys Thr Gly Ser Glu Val Ser Ser Val 
225                 230                 235                 240 


Phe Ile Phe Pro Pro Lys Pro Lys Asp Val Leu Thr Ile Thr Leu Thr 
                245                 250                 255     


Pro Lys Val Thr Cys Val Val Val Asp Ile Ser Gln Asp Asp Pro Glu 
            260                 265                 270         


Val His Phe Ser Trp Phe Val Asp Asp Val Glu Val His Thr Ala Gln 
        275                 280                 285             


Thr Arg Pro Pro Glu Glu Gln Phe Asn Ser Thr Phe Arg Ser Val Ser 
    290                 295                 300                 


Glu Leu Pro Ile Leu His Gln Asp Trp Leu Asn Gly Arg Thr Phe Arg 
305                 310                 315                 320 


Cys Lys Val Thr Ser Ala Ala Phe Pro Ser Pro Ile Glu Lys Thr Ile 
                325                 330                 335     


Ser Lys Pro Glu Gly Arg Thr Gln Val Pro His Val Tyr Thr Met Ser 
            340                 345                 350         


Pro Thr Lys Glu Glu Met Thr Gln Asn Glu Val Ser Ile Thr Cys Met 
        355                 360                 365             


Val Lys Gly Phe Tyr Pro Pro Asp Ile Tyr Val Glu Trp Gln Met Asn 
    370                 375                 380                 


Gly Gln Pro Gln Glu Asn Tyr Lys Asn Thr Pro Pro Thr Met Asp Thr 
385                 390                 395                 400 


Asp Gly Ser Tyr Phe Leu Tyr Ser Lys Leu Asn Val Lys Lys Glu Lys 
                405                 410                 415     


Trp Gln Gln Gly Asn Thr Phe Thr Cys Ser Val Leu His Glu Gly Leu 
            420                 425                 430         


His Asn His His Thr Glu Lys Ser Leu Ser His Ser Pro Gly 
        435                 440                 445     


<210>  6
<211>  214
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exemplified LC

<400>  6

Asp Ile Val Met Thr Gln Ser Gln Lys Phe Met Ser Thr Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Ser Val Thr Cys Lys Ala Ser Gln Asn Val Gly Thr Asn 
            20                  25                  30          


Val Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ser Pro Lys Ala Leu Ile 
        35                  40                  45              


Tyr Ser Ala Ser Tyr Arg Tyr Ser Gly Val Pro Asp Arg Phe Thr Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Asn Val Gln Ser 
65                  70                  75                  80  


Glu Asp Leu Ala Glu Tyr Phe Cys Gln Gln Tyr Asn Asp Tyr Pro Leu 
                85                  90                  95      


Thr Phe Gly Ala Gly Thr Arg Leu Glu Ile Lys Arg Ala Asp Ala Ala 
            100                 105                 110         


Pro Thr Val Ser Ile Phe Pro Pro Ser Thr Glu Gln Leu Ala Thr Gly 
        115                 120                 125             


Gly Ala Ser Val Val Cys Leu Met Asn Asn Phe Tyr Pro Arg Asp Ile 
    130                 135                 140                 


Ser Val Lys Trp Lys Ile Asp Gly Thr Glu Arg Arg Asp Gly Val Leu 
145                 150                 155                 160 


Asp Ser Val Thr Asp Gln Asp Ser Lys Asp Ser Thr Tyr Ser Met Ser 
                165                 170                 175     


Ser Thr Leu Ser Leu Ser Lys Ala Asp Tyr Glu Ser His Asn Leu Tyr 
            180                 185                 190         


Thr Cys Glu Val Val His Lys Thr Ser Ser Ser Pro Val Val Lys Ser 
        195                 200                 205             


Phe Asn Arg Asn Glu Cys 
    210                 


<210>  7
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exemplified HCVR

<400>  7

Gln Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Val Arg Pro Gly Thr 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Ala Phe Thr Asn Tyr 
            20                  25                  30          


Tyr Ile Glu Trp Leu Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Val Ile Asn Pro Gly Trp Gly Asp Thr Asn Tyr Asn Glu Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Ala Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Gln Leu Ser Ser Leu Thr Ser Asp Asp Ser Ala Val Phe Phe Cys 
                85                  90                  95      


Ala Arg Arg Asp Thr Arg His Gly Tyr Tyr Ala Leu Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Ser Val Thr Val Ser Ser 
        115                 120     


<210>  8
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exemplified LCVR

<400>  8

Asp Ile Val Met Thr Gln Ser Gln Lys Phe Met Ser Thr Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Ser Val Thr Cys Lys Ala Ser Gln Asn Val Gly Thr Asn 
            20                  25                  30          


Val Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ser Pro Lys Ala Leu Ile 
        35                  40                  45              


Tyr Ser Ala Ser Tyr Arg Tyr Ser Gly Val Pro Asp Arg Phe Thr Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Asn Val Gln Ser 
65                  70                  75                  80  


Glu Asp Leu Ala Glu Tyr Phe Cys Gln Gln Tyr Asn Asp Tyr Pro Leu 
                85                  90                  95      


Thr Phe Gly Ala Gly Thr Arg Leu Glu Ile Lys 
            100                 105         


<210>  9
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exemplified HCDR1

<400>  9

Lys Ala Ser Gly Tyr Ala Phe Thr Asn Tyr Tyr Ile Glu 
1               5                   10              


<210>  10
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exemplified HCDR2

<400>  10

Val Ile Asn Pro Gly Trp Gly Asp Thr Asn Tyr Asn Glu Lys Phe Lys 
1               5                   10                  15      


Gly 
    


<210>  11
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exemplified HCDR3


<220>
<221>  MISC_FEATURE
<222>  (6)..(6)
<223>  Xaa at pos. 6 is Ala or Arg

<220>
<221>  MISC_FEATURE
<222>  (14)..(14)
<223>  Xaa at pos. 14 is Pro or Tyr

<400>  11

Ala Arg Arg Asp Thr Xaa His Gly Tyr Tyr Ala Leu Asp Xaa 
1               5                   10                  


<210>  12
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exemplified LCDR1

<400>  12

Lys Ala Ser Gln Asn Val Gly Thr Asn Val Ala 
1               5                   10      


<210>  13
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exemplified LCDR2

<400>  13

Tyr Ser Ala Ser Tyr Arg Tyr Ser 
1               5               


<210>  14
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exemplified LCDR3


<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  Xaa at pos. 4 is Trp or Asn

<400>  14

Gln Gln Tyr Xaa Asp Tyr Pro Leu Thr 
1               5                   


<210>  15
<211>  1341
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Exemplified DNA encoding the HC of SEQ ID NO: 1

<400>  15
caggtgcagc tggtgcagtc tggggctgag gtgaagaagc ctgggtcctc agtgaaggtt       60

tcctgcaagg catctggcta cgccttcacc aactactata tcgagtgggt gcgacaggcc      120

cctggacaag ggcttgagtg gatgggagtg atcaaccccg gctggggcga cacgaactac      180

aacgagaagt tcaagggcag agtcaccatt accgcggaca aatccacgag cacagcctac      240

atggagctga gcagcctgag atctgaggac acggccgtgt attactgtgc gagacgcgat      300

acggctcacg gctactacgc ccttgatccg tggggccaag gaaccacggt caccgtctcc      360

tcagcctcca ccaagggccc atcggtcttc ccgctagcgc cctgctccag gagcacctcc      420

gagagcacag ccgccctggg ctgcctggtc aaggactact tccccgaacc ggtgacggtg      480

tcgtggaact caggcgccct gaccagcggc gtgcacacct tcccggctgt cctacagtcc      540

tcaggactct actccctcag cagcgtggtg accgtgccct ccagcagctt gggcacgaag      600

acctacacct gcaacgtaga tcacaagccc agcaacacca aggtggacaa gagagttgag      660

tccaaatatg gtcccccatg cccaccctgc ccagcacctg aggccgccgg gggaccatca      720

gtcttcctgt tccccccaaa acccaaggac actctcatga tctcccggac ccctgaggtc      780

acgtgcgtgg tggtggacgt gagccaggaa gaccccgagg tccagttcaa ctggtacgtg      840

gatggcgtgg aggtgcataa tgccaagaca aagccgcggg aggagcagtt caacagcacg      900

taccgtgtgg tcagcgtcct caccgtcctg caccaggact ggctgaacgg caaggagtac      960

aagtgcaagg tctccaacaa aggcctcccg tcctccatcg agaaaaccat ctccaaagcc     1020

aaagggcagc cccgagagcc acaggtgtac accctgcccc catcccagga ggagatgacc     1080

aagaaccagg tcagcctgac ctgcctggtc aaaggcttct accccagcga catcgccgtg     1140

gagtgggaaa gcaatgggca gccggagaac aactacaaga ccacgcctcc cgtgctggac     1200

tccgacggct ccttcttcct ctacagcagg ctaaccgtgg acaagagcag gtggcaggag     1260

gggaatgtct tctcatgctc cgtgatgcat gaggctctgc acaaccacta cacacagaag     1320

agcctctccc tgtctctggg t                                               1341


<210>  16
<211>  642
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Exemplified DNA encoding the LC of SEQ ID NO: 2

<400>  16
gacatccaga tgacccagtc tccatcctct ctgtctgcat ctgtaggaga cagagtcacc       60

atcacttgca aggccagcca gaatgtgggc accaacgtgg cctggtatca gcagaaacca      120

gggaaagccc ctaagctcct gatctatagc gccagctaca gatacagcgg ggtcccatca      180

aggttcagtg gcagtggatc tgggacagat ttcactctca ccatcagcag tctgcaacct      240

gaagattttg caacttacta ctgtcagcag tactgggact accccctgac cttcggcgga      300

gggaccaagg tggagatcaa acggactgtg gctgcaccat ctgtcttcat cttcccgcca      360

tctgatgagc agttgaaatc tggaactgcc tctgttgtgt gcctgctgaa taacttctat      420

cccagagagg ccaaagtaca gtggaaggtg gataacgccc tccaatcggg taactcccag      480

gagagtgtca cagagcagga cagcaaggac agcacctaca gcctcagcag caccctgacg      540

ctgagcaaag cagactacga gaaacacaaa gtctacgcct gcgaagtcac ccatcagggc      600

ctgagctcgc ccgtcacaaa gagcttcaac aggggagagt gc                         642


<210>  17
<211>  161
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  human RANKL

<400>  17

Met Ser Lys Leu Glu Ala Gln Pro Phe Ala His Leu Thr Ile Asn Ala 
1               5                   10                  15      


Thr Asp Ile Pro Ser Gly Ser His Lys Val Ser Leu Ser Ser Trp Tyr 
            20                  25                  30          


His Asp Arg Gly Trp Ala Lys Ile Ser Asn Met Thr Phe Ser Asn Gly 
        35                  40                  45              


Lys Leu Ile Val Asn Gln Asp Gly Phe Tyr Tyr Leu Tyr Ala Asn Ile 
    50                  55                  60                  


Cys Phe Arg His His Glu Thr Ser Gly Asp Leu Ala Thr Glu Tyr Leu 
65                  70                  75                  80  


Gln Leu Met Val Tyr Val Thr Lys Thr Ser Ile Lys Ile Pro Ser Ser 
                85                  90                  95      


His Thr Leu Met Lys Gly Gly Ser Thr Lys Tyr Trp Ser Gly Asn Ser 
            100                 105                 110         


Glu Phe His Phe Tyr Ser Ile Asn Val Gly Gly Phe Phe Lys Leu Arg 
        115                 120                 125             


Ser Gly Glu Glu Ile Ser Ile Glu Val Ser Asn Pro Ser Leu Leu Asp 
    130                 135                 140                 


Pro Asp Gln Asp Ala Thr Tyr Phe Gly Ala Phe Lys Val Arg Asp Ile 
145                 150                 155                 160 


Asp 
    


