                         SEQUENCE LISTING

<110>  GENETHON et al.
 
<120>  COMPOSITIONS AND METHODS FOR THE TREATMENT OF MYOTONIC DYSTROPHY

<130>  B2347PC00

<160>  92    

<170>  PatentIn version 3.5

<210>  1
<211>  22
<212>  RNA
<213>  artificial

<220>
<223>  Guide sequence sgRNA 1

<400>  1
gccccggagu cgaagacagu uc                                                22


<210>  2
<211>  21
<212>  RNA
<213>  artificial

<220>
<223>  Guide sequence sgRNA 4

<400>  2
caguucacaa ccgcuccgag c                                                 21


<210>  3
<211>  21
<212>  RNA
<213>  artificial

<220>
<223>  Guide sequence sgRNA 7

<400>  3
gcggccggcg aacggggcuc g                                                 21


<210>  4
<211>  22
<212>  RNA
<213>  artificial

<220>
<223>  Guide sequence sgRNA 8B

<400>  4
ggcucgaagg guccuuguag cc                                                22


<210>  5
<211>  22
<212>  RNA
<213>  artificial

<220>
<223>  Guide sequence sgRNA 23

<400>  5
gacaauaaau accgaggaau gu                                                22


<210>  6
<211>  81
<212>  RNA
<213>  artificial

<220>
<223>  Sa sgRNA constant moiety

<400>  6
guuuuaguac ucuggaaaca gaaucuacua aaacaaggca aaaugccgug uuuaucucgu       60

caacuuguug gcgagauuuu u                                                 81


<210>  7
<211>  15
<212>  RNA
<213>  artificial

<220>
<223>  minimum guide sequence sgRNA 1

<400>  7
agucgaagac aguuc                                                        15


<210>  8
<211>  15
<212>  RNA
<213>  artificial

<220>
<223>  minimum guide sequence sgRNA 4

<400>  8
acaaccgcuc cgagc                                                        15


<210>  9
<211>  15
<212>  RNA
<213>  artificial

<220>
<223>  minimum guide sequence sgRNA 7

<400>  9
ggcgaacggg gcucg                                                        15


<210>  10
<211>  15
<212>  RNA
<213>  artificial

<220>
<223>  minimum guide sequence sgRNA 8B

<400>  10
aggguccuug uagcc                                                        15


<210>  11
<211>  15
<212>  RNA
<213>  artificial

<220>
<223>  minimun guide sequence sgRNA 23

<400>  11
aauaccgagg aaugu                                                        15


<210>  12
<211>  103
<212>  DNA
<213>  artificial

<220>
<223>  coding sequence Sa sgRNA 1

<400>  12
gccccggagt cgaagacagt tcgttttagt actctggaaa cagaatctac taaaacaagg       60

caaaatgccg tgtttatctc gtcaacttgt tggcgagatt ttt                        103


<210>  13
<211>  103
<212>  DNA
<213>  artificial

<220>
<223>  coding sequence Sa sgRNA 4

<400>  13
gcagttcaca accgctccga gcgttttagt actctggaaa cagaatctac taaaacaagg       60

caaaatgccg tgtttatctc gtcaacttgt tggcgagatt ttt                        103


<210>  14
<211>  102
<212>  DNA
<213>  artificial

<220>
<223>  coding sequence Sa sgRNA 7

<400>  14
gcggccggcg aacggggctc ggttttagta ctctggaaac agaatctact aaaacaaggc       60

aaaatgccgt gtttatctcg tcaacttgtt ggcgagattt tt                         102


<210>  15
<211>  103
<212>  DNA
<213>  artificial

<220>
<223>  coding sequence Sa sgRNA 8B

<400>  15
ggctcgaagg gtccttgtag ccgttttagt actctggaaa cagaatctac taaaacaagg       60

caaaatgccg tgtttatctc gtcaacttgt tggcgagatt ttt                        103


<210>  16
<211>  103
<212>  DNA
<213>  artificial

<220>
<223>  coding sequence Sa sgRNA 23

<400>  16
gacaataaat accgaggaat gtgttttagt actctggaaa cagaatctac taaaacaagg       60

caaaatgccg tgtttatctc gtcaacttgt tggcgagatt ttt                        103


<210>  17
<211>  249
<212>  DNA
<213>  artificial

<220>
<223>  U6 promoter

<400>  17
gagggcctat ttcccatgat tccttcatat ttgcatatac gatacaaggc tgttagagag       60

ataattggaa ttaatttgac tgtaaacaca aagatattag tacaaaatac gtgacgtaga      120

aagtaataat ttcttgggta gtttgcagtt ttaaaattat gttttaaaat ggactatcat      180

atgcttaccg taacttgaaa gtatttcgat ttcttggctt tatatatctt gtggaaagga      240

cgaaacacc                                                              249


<210>  18
<211>  22
<212>  RNA
<213>  artificial

<220>
<223>  Guide sequence sgRNA 4 + G

<400>  18
gcaguucaca accgcuccga gc                                                22


<210>  19
<211>  22
<212>  DNA
<213>  artificial

<220>
<223>  Protospacer seq 1

<400>  19
gccccggagt cgaagacagt tc                                                22


<210>  20
<211>  22
<212>  DNA
<213>  artificial

<220>
<223>  Protospacer seq 4

<400>  20
gcagttcaca accgctccga gc                                                22


<210>  21
<211>  21
<212>  DNA
<213>  artificial

<220>
<223>  Protospacer seq 7

<400>  21
gcggccggcg aacggggctc g                                                 21


<210>  22
<211>  22
<212>  DNA
<213>  artificial

<220>
<223>  Protospacer seq 8B

<400>  22
ggctcgaagg gtccttgtag cc                                                22


<210>  23
<211>  22
<212>  DNA
<213>  artificial

<220>
<223>  Protospacer seq 10

<400>  23
gcggccaggc tgaggccctg ac                                                22


<210>  24
<211>  24
<212>  DNA
<213>  artificial

<220>
<223>  Protospacer seq 15B

<400>  24
ggggggcgcg ggatccccga aaaa                                              24


<210>  25
<211>  21
<212>  DNA
<213>  artificial

<220>
<223>  Protospacer seq 17A

<400>  25
ggctccgccc gcttcggcgg t                                                 21


<210>  26
<211>  24
<212>  DNA
<213>  artificial

<220>
<223>  Protospacer seq 17B

<400>  26
gccggctccg cccgcttcgg cggt                                              24


<210>  27
<211>  22
<212>  DNA
<213>  artificial

<220>
<223>  Protospacer seq 19

<400>  27
gaaaacgtgg attggggttg tt                                                22


<210>  28
<211>  22
<212>  DNA
<213>  artificial

<220>
<223>  Protospacer seq 22

<400>  28
ggggtctcag tgcatccaaa ac                                                22


<210>  29
<211>  22
<212>  DNA
<213>  artificial

<220>
<223>  Protospacer seq 23

<400>  29
gacaataaat accgaggaat gt                                                22


<210>  30
<211>  28
<212>  DNA
<213>  artificial

<220>
<223>  Genomic target sequence + PAM 1

<400>  30
gccccggagt cgaagacagt tctagggt                                          28


<210>  31
<211>  27
<212>  DNA
<213>  artificial

<220>
<223>  Genomic target sequence + PAM 4

<400>  31
cagttcacaa ccgctccgag cgtgggt                                           27


<210>  32
<211>  27
<212>  DNA
<213>  artificial

<220>
<223>  Genomic target sequence + PAM 7

<400>  32
gcggccggcg aacggggctc gaagggt                                           27


<210>  33
<211>  28
<212>  DNA
<213>  artificial

<220>
<223>  Genomic target sequence + PAM 8B

<400>  33
ggctcgaagg gtccttgtag ccgggaat                                          28


<210>  34
<211>  27
<212>  DNA
<213>  artificial

<220>
<223>  Genomic target sequence + PAM 10

<400>  34
cggccaggct gaggccctga cgtggat                                           27


<210>  35
<211>  30
<212>  DNA
<213>  artificial

<220>
<223>  Genomic target sequence + PAM 15B

<400>  35
ggggggcgcg ggatccccga aaaagcgggt                                        30


<210>  36
<211>  27
<212>  DNA
<213>  artificial

<220>
<223>  Genomic target sequence + PAM 17A

<400>  36
ggctccgccc gcttcggcgg tttggat                                           27


<210>  37
<211>  30
<212>  DNA
<213>  artificial

<220>
<223>  Genomic target sequence + PAM 17B

<400>  37
gccggctccg cccgcttcgg cggtttggat                                        30


<210>  38
<211>  27
<212>  DNA
<213>  artificial

<220>
<223>  Genomic target sequence + PAM 19

<400>  38
aaaacgtgga ttggggttgt tgggggt                                           27


<210>  39
<211>  28
<212>  DNA
<213>  artificial

<220>
<223>  Genomic target sequence + PAM 22

<400>  39
ggggtctcag tgcatccaaa acgtggat                                          28


<210>  40
<211>  28
<212>  DNA
<213>  artificial

<220>
<223>  Genomic target sequence + PAM 23

<400>  40
gacaataaat accgaggaat gtcggggt                                          28


<210>  41
<211>  755
<212>  DNA
<213>  artificial

<220>
<223>  DMPK 3'-UTR from the stop codon to the polyA

<400>  41
tgaaccctag aactgtcttc gactccgggg ccccgttgga agactgagtg cccggggcac       60

ggcacagaag ccgcgcccac cgcctgccag ttcacaaccg ctccgagcgt gggtctccgc      120

ccagctccag tcctgtgatc cgggcccgcc ccctagcggc cggggaggga ggggccgggt      180

ccgcggccgg cgaacggggc tcgaagggtc cttgtagccg ggaatgctgc tgctgctgct      240

gctgctgctg ctgctgctgc tgctgctgct gctgctgctg ctgctggggg gatcacagac      300

catttctttc tttcggccag gctgaggccc tgacgtggat gggcaaactg caggcctggg      360

aaggcagcaa gccgggccgt ccgtgttcca tcctccacgc acccccacct atcgttggtt      420

cgcaaagtgc aaagctttct tgtgcatgac gccctgctct ggggagcgtc tggcgcgatc      480

tctgcctgct tactcgggaa atttgctttt gccaaacccg ctttttcggg gatcccgcgc      540

ccccctcctc acttgcgctg ctctcggagc cccagccggc tccgcccgct tcggcggttt      600

ggatatttat tgacctcgtc ctccgactcg ctgacaggct acaggacccc caacaacccc      660

aatccacgtt ttggatgcac tgagaccccg acattcctcg gtatttattg tctgtcccca      720

cctaggaccc ccacccccga ccctcgcgaa taaaa                                 755


<210>  42
<211>  1114
<212>  PRT
<213>  artificial

<220>
<223>  SaCas9 from plasmid Addgene61591

<400>  42

Met Ala Pro Lys Lys Lys Arg Lys Val Gly Ile His Gly Val Pro Ala 
1               5                   10                  15      


Ala Lys Arg Asn Tyr Ile Leu Gly Leu Asp Ile Gly Ile Thr Ser Val 
            20                  25                  30          


Gly Tyr Gly Ile Ile Asp Tyr Glu Thr Arg Asp Val Ile Asp Ala Gly 
        35                  40                  45              


Val Arg Leu Phe Lys Glu Ala Asn Val Glu Asn Asn Glu Gly Arg Arg 
    50                  55                  60                  


Ser Lys Arg Gly Ala Arg Arg Leu Lys Arg Arg Arg Arg His Arg Ile 
65                  70                  75                  80  


Gln Arg Val Lys Lys Leu Leu Phe Asp Tyr Asn Leu Leu Thr Asp His 
                85                  90                  95      


Ser Glu Leu Ser Gly Ile Asn Pro Tyr Glu Ala Arg Val Lys Gly Leu 
            100                 105                 110         


Ser Gln Lys Leu Ser Glu Glu Glu Phe Ser Ala Ala Leu Leu His Leu 
        115                 120                 125             


Ala Lys Arg Arg Gly Val His Asn Val Asn Glu Val Glu Glu Asp Thr 
    130                 135                 140                 


Gly Asn Glu Leu Ser Thr Lys Glu Gln Ile Ser Arg Asn Ser Lys Ala 
145                 150                 155                 160 


Leu Glu Glu Lys Tyr Val Ala Glu Leu Gln Leu Glu Arg Leu Lys Lys 
                165                 170                 175     


Asp Gly Glu Val Arg Gly Ser Ile Asn Arg Phe Lys Thr Ser Asp Tyr 
            180                 185                 190         


Val Lys Glu Ala Lys Gln Leu Leu Lys Val Gln Lys Ala Tyr His Gln 
        195                 200                 205             


Leu Asp Gln Ser Phe Ile Asp Thr Tyr Ile Asp Leu Leu Glu Thr Arg 
    210                 215                 220                 


Arg Thr Tyr Tyr Glu Gly Pro Gly Glu Gly Ser Pro Phe Gly Trp Lys 
225                 230                 235                 240 


Asp Ile Lys Glu Trp Tyr Glu Met Leu Met Gly His Cys Thr Tyr Phe 
                245                 250                 255     


Pro Glu Glu Leu Arg Ser Val Lys Tyr Ala Tyr Asn Ala Asp Leu Tyr 
            260                 265                 270         


Asn Ala Leu Asn Asp Leu Asn Asn Leu Val Ile Thr Arg Asp Glu Asn 
        275                 280                 285             


Glu Lys Leu Glu Tyr Tyr Glu Lys Phe Gln Ile Ile Glu Asn Val Phe 
    290                 295                 300                 


Lys Gln Lys Lys Lys Pro Thr Leu Lys Gln Ile Ala Lys Glu Ile Leu 
305                 310                 315                 320 


Val Asn Glu Glu Asp Ile Lys Gly Tyr Arg Val Thr Ser Thr Gly Lys 
                325                 330                 335     


Pro Glu Phe Thr Asn Leu Lys Val Tyr His Asp Ile Lys Asp Ile Thr 
            340                 345                 350         


Ala Arg Lys Glu Ile Ile Glu Asn Ala Glu Leu Leu Asp Gln Ile Ala 
        355                 360                 365             


Lys Ile Leu Thr Ile Tyr Gln Ser Ser Glu Asp Ile Gln Glu Glu Leu 
    370                 375                 380                 


Thr Asn Leu Asn Ser Glu Leu Thr Gln Glu Glu Ile Glu Gln Ile Ser 
385                 390                 395                 400 


Asn Leu Lys Gly Tyr Thr Gly Thr His Asn Leu Ser Leu Lys Ala Ile 
                405                 410                 415     


Asn Leu Ile Leu Asp Glu Leu Trp His Thr Asn Asp Asn Gln Ile Ala 
            420                 425                 430         


Ile Phe Asn Arg Leu Lys Leu Val Pro Lys Lys Val Asp Leu Ser Gln 
        435                 440                 445             


Gln Lys Glu Ile Pro Thr Thr Leu Val Asp Asp Phe Ile Leu Ser Pro 
    450                 455                 460                 


Val Val Lys Arg Ser Phe Ile Gln Ser Ile Lys Val Ile Asn Ala Ile 
465                 470                 475                 480 


Ile Lys Lys Tyr Gly Leu Pro Asn Asp Ile Ile Ile Glu Leu Ala Arg 
                485                 490                 495     


Glu Lys Asn Ser Lys Asp Ala Gln Lys Met Ile Asn Glu Met Gln Lys 
            500                 505                 510         


Arg Asn Arg Gln Thr Asn Glu Arg Ile Glu Glu Ile Ile Arg Thr Thr 
        515                 520                 525             


Gly Lys Glu Asn Ala Lys Tyr Leu Ile Glu Lys Ile Lys Leu His Asp 
    530                 535                 540                 


Met Gln Glu Gly Lys Cys Leu Tyr Ser Leu Glu Ala Ile Pro Leu Glu 
545                 550                 555                 560 


Asp Leu Leu Asn Asn Pro Phe Asn Tyr Glu Val Asp His Ile Ile Pro 
                565                 570                 575     


Arg Ser Val Ser Phe Asp Asn Ser Phe Asn Asn Lys Val Leu Val Lys 
            580                 585                 590         


Gln Glu Glu Asn Ser Lys Lys Gly Asn Arg Thr Pro Phe Gln Tyr Leu 
        595                 600                 605             


Ser Ser Ser Asp Ser Lys Ile Ser Tyr Glu Thr Phe Lys Lys His Ile 
    610                 615                 620                 


Leu Asn Leu Ala Lys Gly Lys Gly Arg Ile Ser Lys Thr Lys Lys Glu 
625                 630                 635                 640 


Tyr Leu Leu Glu Glu Arg Asp Ile Asn Arg Phe Ser Val Gln Lys Asp 
                645                 650                 655     


Phe Ile Asn Arg Asn Leu Val Asp Thr Arg Tyr Ala Thr Arg Gly Leu 
            660                 665                 670         


Met Asn Leu Leu Arg Ser Tyr Phe Arg Val Asn Asn Leu Asp Val Lys 
        675                 680                 685             


Val Lys Ser Ile Asn Gly Gly Phe Thr Ser Phe Leu Arg Arg Lys Trp 
    690                 695                 700                 


Lys Phe Lys Lys Glu Arg Asn Lys Gly Tyr Lys His His Ala Glu Asp 
705                 710                 715                 720 


Ala Leu Ile Ile Ala Asn Ala Asp Phe Ile Phe Lys Glu Trp Lys Lys 
                725                 730                 735     


Leu Asp Lys Ala Lys Lys Val Met Glu Asn Gln Met Phe Glu Glu Lys 
            740                 745                 750         


Gln Ala Glu Ser Met Pro Glu Ile Glu Thr Glu Gln Glu Tyr Lys Glu 
        755                 760                 765             


Ile Phe Ile Thr Pro His Gln Ile Lys His Ile Lys Asp Phe Lys Asp 
    770                 775                 780                 


Tyr Lys Tyr Ser His Arg Val Asp Lys Lys Pro Asn Arg Glu Leu Ile 
785                 790                 795                 800 


Asn Asp Thr Leu Tyr Ser Thr Arg Lys Asp Asp Lys Gly Asn Thr Leu 
                805                 810                 815     


Ile Val Asn Asn Leu Asn Gly Leu Tyr Asp Lys Asp Asn Asp Lys Leu 
            820                 825                 830         


Lys Lys Leu Ile Asn Lys Ser Pro Glu Lys Leu Leu Met Tyr His His 
        835                 840                 845             


Asp Pro Gln Thr Tyr Gln Lys Leu Lys Leu Ile Met Glu Gln Tyr Gly 
    850                 855                 860                 


Asp Glu Lys Asn Pro Leu Tyr Lys Tyr Tyr Glu Glu Thr Gly Asn Tyr 
865                 870                 875                 880 


Leu Thr Lys Tyr Ser Lys Lys Asp Asn Gly Pro Val Ile Lys Lys Ile 
                885                 890                 895     


Lys Tyr Tyr Gly Asn Lys Leu Asn Ala His Leu Asp Ile Thr Asp Asp 
            900                 905                 910         


Tyr Pro Asn Ser Arg Asn Lys Val Val Lys Leu Ser Leu Lys Pro Tyr 
        915                 920                 925             


Arg Phe Asp Val Tyr Leu Asp Asn Gly Val Tyr Lys Phe Val Thr Val 
    930                 935                 940                 


Lys Asn Leu Asp Val Ile Lys Lys Glu Asn Tyr Tyr Glu Val Asn Ser 
945                 950                 955                 960 


Lys Cys Tyr Glu Glu Ala Lys Lys Leu Lys Lys Ile Ser Asn Gln Ala 
                965                 970                 975     


Glu Phe Ile Ala Ser Phe Tyr Asn Asn Asp Leu Ile Lys Ile Asn Gly 
            980                 985                 990         


Glu Leu Tyr Arg Val Ile Gly Val  Asn Asn Asp Leu Leu  Asn Arg Ile 
        995                 1000                 1005             


Glu Val  Asn Met Ile Asp Ile  Thr Tyr Arg Glu Tyr  Leu Glu Asn 
    1010                 1015                 1020             


Met Asn  Asp Lys Arg Pro Pro  Arg Ile Ile Lys Thr  Ile Ala Ser 
    1025                 1030                 1035             


Lys Thr  Gln Ser Ile Lys Lys  Tyr Ser Thr Asp Ile  Leu Gly Asn 
    1040                 1045                 1050             


Leu Tyr  Glu Val Lys Ser Lys  Lys His Pro Gln Ile  Ile Lys Lys 
    1055                 1060                 1065             


Gly Lys  Arg Pro Ala Ala Thr  Lys Lys Ala Gly Gln  Ala Lys Lys 
    1070                 1075                 1080             


Lys Lys  Gly Ser Tyr Pro Tyr  Asp Val Pro Asp Tyr  Ala Tyr Pro 
    1085                 1090                 1095             


Tyr Asp  Val Pro Asp Tyr Ala  Tyr Pro Tyr Asp Val  Pro Asp Tyr 
    1100                 1105                 1110             


Ala 
    


<210>  43
<211>  22
<212>  DNA
<213>  artificial

<220>
<223>  coding sequence guide sequence sgRNA 1

<400>  43
gccccggagt cgaagacagt tc                                                22


<210>  44
<211>  22
<212>  DNA
<213>  artificial

<220>
<223>  coding sequence guide sequence sgRNA 4

<400>  44
gcagttcaca accgctccga gc                                                22


<210>  45
<211>  21
<212>  DNA
<213>  artificial

<220>
<223>  coding sequence guide sequence sgRNA 7

<400>  45
gcggccggcg aacggggctc g                                                 21


<210>  46
<211>  22
<212>  DNA
<213>  artificial

<220>
<223>  coding sequence guide sequence sgRNA 8B

<400>  46
ggctcgaagg gtccttgtag cc                                                22


<210>  47
<211>  22
<212>  DNA
<213>  artificial

<220>
<223>  coding sequence guide sequence sgRNA 23

<400>  47
gacaataaat accgaggaat gt                                                22


<210>  48
<211>  81
<212>  DNA
<213>  artificial

<220>
<223>  sgRNA constant moiety (as in the plasmid)

<400>  48
gttttagtac tctggaaaca gaatctacta aaacaaggca aaatgccgtg tttatctcgt       60

caacttgttg gcgagatttt t                                                 81


<210>  49
<211>  40
<212>  DNA
<213>  artificial

<220>
<223>  primer

<400>  49
cgctcgagcg ccggcgtgag gctccggtgc ccgtcagtgg                             40


<210>  50
<211>  43
<212>  DNA
<213>  artificial

<220>
<223>  primer

<400>  50
cgcccgggtc gcgatcacga cacctgtgtt ctggcggcaa acc                         43


<210>  51
<211>  30
<212>  DNA
<213>  artificial

<220>
<223>  primer

<400>  51
gcgaccggtg ccaccatggc cccaaagaag                                        30


<210>  52
<211>  44
<212>  DNA
<213>  artificial

<220>
<223>  primer

<400>  52
cgcgtcgacc ttaagcgtaa tctggaacat cgtatgggta agcg                        44


<210>  53
<211>  32
<212>  DNA
<213>  artificial

<220>
<223>  primer

<400>  53
gcggtttaaa cgccaccatg gccccaaaga ag                                     32


<210>  54
<211>  39
<212>  DNA
<213>  artificial

<220>
<223>  primer

<400>  54
ccgcggccgc gcgagctcta ggaattctta agcgtaatc                              39


<210>  55
<211>  38
<212>  DNA
<213>  artificial

<220>
<223>  primer

<400>  55
ggaggtacct taagcaattg gacatagtcg tttaaacc                               38


<210>  56
<211>  31
<212>  DNA
<213>  artificial

<220>
<223>  primer

<400>  56
cctcacgtgt cctgcggccg caaaaatctc g                                      31


<210>  57
<211>  25
<212>  DNA
<213>  artificial

<220>
<223>  primer

<400>  57
caccgcggcc ggcgaacggg gctcg                                             25


<210>  58
<211>  25
<212>  DNA
<213>  artificial

<220>
<223>  primer

<400>  58
aaaccgagcc ccgttcgccg gccgc                                             25


<210>  59
<211>  26
<212>  DNA
<213>  artificial

<220>
<223>  primer

<400>  59
caccggctcg aagggtcctt gtagcc                                            26


<210>  60
<211>  26
<212>  DNA
<213>  artificial

<220>
<223>  primer

<400>  60
aaacggctac aaggaccctt cgagcc                                            26


<210>  61
<211>  26
<212>  DNA
<213>  artificial

<220>
<223>  primer

<400>  61
caccgcggcc aggctgaggc cctgac                                            26


<210>  62
<211>  26
<212>  DNA
<213>  artificial

<220>
<223>  primer

<400>  62
aaacgtcagg gcctcagcct ggccgc                                            26


<210>  63
<211>  28
<212>  DNA
<213>  artificial

<220>
<223>  primer

<400>  63
caccgggggg cgcgggatcc ccgaaaaa                                          28


<210>  64
<211>  28
<212>  DNA
<213>  artificial

<220>
<223>  primer

<400>  64
aaactttttc ggggatcccg cgcccccc                                          28


<210>  65
<211>  25
<212>  DNA
<213>  artificial

<220>
<223>  primer

<400>  65
caccggctcc gcccgcttcg gcggt                                             25


<210>  66
<211>  25
<212>  DNA
<213>  artificial

<220>
<223>  primer

<400>  66
aaacaccgcc gaagcgggcg gagcc                                             25


<210>  67
<211>  28
<212>  DNA
<213>  artificial

<220>
<223>  primer

<400>  67
caccgccggc tccgcccgct tcggcggt                                          28


<210>  68
<211>  28
<212>  DNA
<213>  artificial

<220>
<223>  primer

<400>  68
aaacaccgcc gaagcgggcg gagccggc                                          28


<210>  69
<211>  26
<212>  DNA
<213>  artificial

<220>
<223>  primer

<400>  69
caccgaaaac gtggattggg gttgtt                                            26


<210>  70
<211>  26
<212>  DNA
<213>  artificial

<220>
<223>  primer

<400>  70
aaacaacaac cccaatccac gttttc                                            26


<210>  71
<211>  26
<212>  DNA
<213>  artificial

<220>
<223>  primer

<400>  71
caccggggtc tcagtgcatc caaaac                                            26


<210>  72
<211>  26
<212>  DNA
<213>  artificial

<220>
<223>  primer

<400>  72
aaacgttttg gatgcactga gacccc                                            26


<210>  73
<211>  26
<212>  DNA
<213>  artificial

<220>
<223>  primer

<400>  73
caccgacaat aaataccgag gaatgt                                            26


<210>  74
<211>  26
<212>  DNA
<213>  artificial

<220>
<223>  primer

<400>  74
aaacacattc ctcggtattt attgtc                                            26


<210>  75
<211>  21
<212>  DNA
<213>  artificial

<220>
<223>  primer

<400>  75
gttcgccgtt gttctgtctc g                                                 21


<210>  76
<211>  21
<212>  DNA
<213>  artificial

<220>
<223>  primer

<400>  76
tccagagctt tgggcagatg g                                                 21


<210>  77
<211>  30
<212>  DNA
<213>  artificial

<220>
<223>  primer

<400>  77
ccgggtaccg ttcgccgttg ttctgtctcg                                        30


<210>  78
<211>  31
<212>  DNA
<213>  artificial

<220>
<223>  primer

<400>  78
ccgctctaga tccagagctt tgggcagatg g                                      31


<210>  79
<211>  21
<212>  DNA
<213>  artificial

<220>
<223>  primer

<400>  79
gtcccaggag ccaatcagag g                                                 21


<210>  80
<211>  21
<212>  DNA
<213>  artificial

<220>
<223>  primer

<400>  80
ctagctcctc ccagaccttc g                                                 21


<210>  81
<211>  23
<212>  DNA
<213>  artificial

<220>
<223>  primer

<400>  81
gcaagaccct gatgaagaag ctc                                               23


<210>  82
<211>  19
<212>  DNA
<213>  artificial

<220>
<223>  primer

<400>  82
gacagaaggc cggatgctg                                                    19


<210>  83
<211>  20
<212>  DNA
<213>  artificial

<220>
<223>  primer

<400>  83
atcttcaagc tccgggccct                                                   20


<210>  84
<211>  20
<212>  DNA
<213>  artificial

<220>
<223>  primer

<400>  84
cagctctgcc tgaagatgtg                                                   20


<210>  85
<211>  21
<212>  DNA
<213>  artificial

<220>
<223>  primer

<400>  85
gctgcccaat accaggtcaa c                                                 21


<210>  86
<211>  22
<212>  DNA
<213>  artificial

<220>
<223>  primer

<400>  86
tggtgggaga aatgctgtat gc                                                22


<210>  87
<211>  20
<212>  DNA
<213>  artificial

<220>
<223>  primer

<400>  87
ttagaggagg tgatggagca                                                   20


<210>  88
<211>  20
<212>  DNA
<213>  artificial

<220>
<223>  primer

<400>  88
gatactaagg actccatcgc                                                   20


<210>  89
<211>  20
<212>  DNA
<213>  artificial

<220>
<223>  primer

<400>  89
ccaaagacag actctcagat                                                   20


<210>  90
<211>  20
<212>  DNA
<213>  artificial

<220>
<223>  primer

<400>  90
aacatcgcca agggacctgc                                                   20


<210>  91
<211>  21
<212>  DNA
<213>  artificial

<220>
<223>  primer

<400>  91
agaacctcaa tgatgtgctg g                                                 21


<210>  92
<211>  21
<212>  DNA
<213>  artificial

<220>
<223>  primer

<400>  92
tcgtgttgac tctgatctcg g                                                 21


