               SEQUENCE LISTING

<110> BSN Medical GmbH

<120> Multy-layer wound care product with perforated collagen layer

<130> 15213-PT-WO

<160> 46

<170> BiSSAP 1.3.5

<210> 1
<211> 240
<212> PRT
<213> Streptococcus pyogenes

<223> "Triple helical protein"

<220> 
<223> Triple helical protein

<400> 1
Gly Ser Pro Gly Leu Pro Gly Pro Arg Gly Glu Gln Gly Pro Thr Gly 
1               5                   10                  15      
Pro Thr Gly Pro Ala Gly Pro Arg Gly Leu Gln Gly Leu Gln Gly Leu 
            20                  25                  30          
Gln Gly Glu Arg Gly Glu Gln Gly Pro Thr Gly Pro Ala Gly Pro Arg 
        35                  40                  45              
Gly Leu Gln Gly Glu Arg Gly Glu Gln Gly Pro Thr Gly Leu Ala Gly 
    50                  55                  60                  
Lys Ala Gly Glu Ala Gly Ala Lys Gly Glu Thr Gly Pro Ala Gly Pro 
65                  70                  75                  80  
Gln Gly Pro Arg Gly Glu Gln Gly Pro Gln Gly Leu Pro Gly Lys Asp 
                85                  90                  95      
Gly Glu Ala Gly Ala Gln Gly Pro Ala Gly Pro Met Gly Pro Ala Gly 
            100                 105                 110         
Glu Arg Gly Glu Lys Gly Glu Pro Gly Thr Gln Gly Ala Lys Gly Asp 
        115                 120                 125             
Arg Gly Glu Thr Gly Pro Val Gly Pro Arg Gly Glu Arg Gly Glu Ala 
    130                 135                 140                 
Gly Pro Ala Gly Lys Asp Gly Glu Arg Gly Pro Val Gly Pro Ala Gly 
145                 150                 155                 160 
Lys Asp Gly Gln Asn Gly Gln Asp Gly Leu Pro Gly Lys Asp Gly Lys 
                165                 170                 175     
Asp Gly Gln Asn Gly Lys Asp Gly Leu Pro Gly Lys Asp Gly Lys Asp 
            180                 185                 190         
Gly Gln Asn Gly Lys Asp Gly Leu Pro Gly Lys Asp Gly Lys Asp Gly 
        195                 200                 205             
Gln Asp Gly Lys Asp Gly Leu Pro Gly Lys Asp Gly Lys Asp Gly Leu 
    210                 215                 220                 
Pro Gly Lys Asp Gly Lys Asp Gly Gln Pro Gly Lys Pro Gly Lys Tyr 
225                 230                 235                 240 



<210> 2
<211> 189
<212> PRT
<213> Clostridium perfringens

<223> "Triple helical protein"

<220> 
<223> Triple helical protein

<400> 2
Gly Pro Arg Gly Pro Arg Gly Pro Gln Gly Glu Gln Gly Pro Gln Gly 
1               5                   10                  15      
Glu Arg Gly Phe Thr Gly Pro Gln Gly Pro Val Gly Pro Gln Gly Glu 
            20                  25                  30          
Gln Gly Pro Gln Gly Glu Arg Gly Phe Thr Gly Pro Gln Gly Pro Ile 
        35                  40                  45              
Gly Leu Gln Gly Glu Gln Gly Pro Gln Gly Glu Arg Gly Phe Thr Gly 
    50                  55                  60                  
Pro Gln Gly Pro Val Gly Pro Gln Gly Glu Gln Gly Pro Gln Gly Glu 
65                  70                  75                  80  
Arg Gly Phe Thr Gly Pro Gln Gly Pro Val Gly Pro Gln Gly Glu Gln 
                85                  90                  95      
Gly Pro Gln Gly Glu Arg Gly Phe Thr Gly Pro Gln Gly Pro Ile Gly 
            100                 105                 110         
Pro Gln Gly Glu Gln Gly Pro Gln Gly Glu Arg Gly Phe Thr Gly Pro 
        115                 120                 125             
Gln Gly Pro Ile Gly Pro Gln Gly Asn Gln Gly Pro Ile Gly Pro Gln 
    130                 135                 140                 
Gly Glu Gln Gly Pro Gln Gly Ala Thr Gly Pro Gln Gly Pro Gln Gly 
145                 150                 155                 160 
Pro Val Gly Pro Gln Gly Asn Gln Gly Pro Ile Gly Pro Gln Gly Pro 
                165                 170                 175     
Val Gly Pro Gln Gly Pro Gln Gly Gln Pro Gly Val Asn 
            180                 185                 

<210> 3
<211> 129
<212> PRT
<213> Methylobacterium sp. 4-46

<223> "Triple helical protein"

<220> 
<223> Triple helical protein

<400> 3
Gly Leu Pro Gly Pro Lys Gly Asp Pro Gly Pro Gln Gly Pro Ala Gly 
1               5                   10                  15      
Pro Lys Gly Glu Pro Gly Pro Lys Gly Glu Pro Gly Pro Lys Gly Glu 
            20                  25                  30          
Pro Gly Pro Lys Gly Glu Pro Gly Pro Lys Gly Glu Pro Gly Pro Lys 
        35                  40                  45              
Gly Glu Pro Gly Pro Lys Gly Glu Pro Gly Pro Lys Gly Glu Pro Gly 
    50                  55                  60                  
Pro Arg Gly Glu Ala Gly Pro Gln Gly Ala Leu Gly Pro Lys Gly Glu 
65                  70                  75                  80  
Ala Gly Ser Arg Gly Glu Pro Gly Pro Arg Gly Glu Pro Gly Pro Lys 
                85                  90                  95      
Gly Glu Ala Gly Leu Ala Gly Ala Pro Gly Pro Lys Gly Glu Ala Gly 
            100                 105                 110         
Pro Arg Gly Pro Gln Gly Glu Arg Gly Pro Pro Gly Ala Pro Gly Ala 
        115                 120                 125             
Ala 
    

<210> 4
<211> 246
<212> PRT
<213> Candidatus Solibacter usitatus Ellin6076

<223> "Triple helical protein"

<220> 
<223> Triple helical protein

<400> 4
Gly Pro Ala Gly Pro Ala Gly Pro Gln Gly Pro Ala Gly Pro Ala Gly 
1               5                   10                  15      
Ala Gln Gly Pro Ala Gly Pro Ala Gly Pro Gln Gly Pro Ala Gly Pro 
            20                  25                  30          
Gln Gly Ser Ala Gly Ala Gln Gly Pro Lys Gly Asp Thr Gly Ala Ala 
        35                  40                  45              
Gly Pro Ala Gly Glu Ala Gly Pro Lys Gly Glu Thr Gly Ala Ala Gly 
    50                  55                  60                  
Pro Lys Gly Asp Thr Gly Ala Ala Gly Pro Ala Gly Pro Lys Gly Asp 
65                  70                  75                  80  
Thr Gly Ala Ala Gly Pro Ala Gly Pro Lys Gly Asp Thr Gly Ala Ala 
                85                  90                  95      
Gly Ala Thr Gly Pro Lys Gly Glu Lys Gly Glu Thr Gly Ala Ala Gly 
            100                 105                 110         
Pro Lys Gly Asp Lys Gly Glu Thr Gly Ala Ala Gly Pro Lys Gly Asp 
        115                 120                 125             
Lys Gly Glu Thr Gly Ala Ala Gly Pro Lys Gly Glu Lys Gly Glu Thr 
    130                 135                 140                 
Gly Ala Val Gly Pro Lys Gly Asp Lys Gly Glu Thr Gly Ala Ala Gly 
145                 150                 155                 160 
Pro Lys Gly Asp Arg Gly Glu Thr Gly Ala Val Gly Pro Lys Gly Asp 
                165                 170                 175     
Lys Gly Glu Thr Gly Ala Val Gly Pro Lys Gly Asp Lys Gly Glu Thr 
            180                 185                 190         
Gly Ala Ile Gly Pro Lys Gly Asp Lys Gly Asp Lys Gly Asp Lys Gly 
        195                 200                 205             
Asp Ala Gly Val Ala Gly Pro Gln Gly Ile Gln Gly Val Lys Gly Asp 
    210                 215                 220                 
Thr Gly Leu Gln Gly Pro Lys Gly Asp Ala Gly Pro Gln Gly Ala Pro 
225                 230                 235                 240 
Gly Thr Pro Gly Gly Gly 
                245     

<210> 5
<211> 117
<212> PRT
<213> Rhodopseudomonas palustris TIE-1

<223> "Triple helical protein"

<220> 
<223> Triple helical protein

<400> 5
Gly Arg Pro Gly Pro Gln Gly Pro Arg Gly Arg Pro Gly Glu Pro Gly 
1               5                   10                  15      
Arg Pro Gly Pro Gln Gly His Pro Gly Arg Pro Gly Pro Glu Gly Pro 
            20                  25                  30          
Arg Gly Lys Gln Gly Pro Val Gly Lys Pro Gly Pro Gln Gly Lys Ala 
        35                  40                  45              
Gly Pro Gln Gly Lys Pro Gly Ile Ala Gly Lys Pro Gly Pro Asp Gly 
    50                  55                  60                  
Lys Pro Gly Pro Ile Gly Pro Gln Gly Lys Ala Gly Pro Gln Gly Pro 
65                  70                  75                  80  
Arg Gly Glu Gln Gly Leu Arg Gly Glu Gln Gly Pro Arg Gly Glu Gln 
                85                  90                  95      
Gly Pro Gln Gly Pro Arg Gly Glu Gln Gly Pro Arg Gly Glu Pro Gly 
            100                 105                 110         
Pro Ala Gly Ala Leu 
        115         

<210> 6
<211> 67
<212> PRT
<213> Streptococcus pyogenes

<223> "V domain of Scl 2"

<220> 
<223> V domain of Scl 2

<400> 6
Glu Glu Asn Glu Lys Val Arg Glu Gln Glu Lys Leu Ile Gln Gln Leu 
1               5                   10                  15      
Ser Glu Lys Leu Val Glu Ile Asn Asp Leu Gln Thr Leu Asn Gly Asp 
            20                  25                  30          
Lys Glu Ser Ile Gln Ser Leu Val Asp Tyr Leu Thr Arg Arg Gly Lys 
        35                  40                  45              
Leu Glu Glu Glu Trp Met Glu Tyr Leu Asn Ser Gly Ile Gln Arg Lys 
    50                  55                  60                  
Leu Phe Val 
65          

<210> 7
<211> 86
<212> PRT
<213> Rhodopseudomonas palustris TIE-1

<223> "V domain"

<220> 
<223> V domain

<400> 7
Pro Ser Ile Glu Gln Val Met Pro Trp Leu His Leu Ile Phe Asp Ala 
1               5                   10                  15      
Tyr Glu Asp Tyr Lys Ala Gln Arg Ala Arg Glu Ala Arg Glu Leu Glu 
            20                  25                  30          
Glu Arg Leu Ala Ala Glu Ala Leu Glu Gln Ala Ala Arg Glu Ala Ala 
        35                  40                  45              
Glu Arg Glu Val Ala Ala Ala Ile Glu Ala Ala Asn Ala Glu Ala Glu 
    50                  55                  60                  
Ile Met Leu Asp Asp Glu Thr His Ala Glu Gly Gly Lys Lys Lys Lys 
65                  70                  75                  80  
Lys Arg Lys His Lys Asp 
                85      

<210> 8
<211> 8
<212> PRT
<213> Artificial Sequence

<223> "Cleavage after Gly4"

<220> 
<223> Cleavage after Gly4

<400> 8
Gly Pro Gln Gly Ile Ala Gly Gln 
1               5               

<210> 9
<211> 8
<212> PRT
<213> Artificial Sequence

<223> "Cleavage after Gly4"

<220> 
<223> Cleavage after Gly4

<400> 9
Gly Pro Gln Gly Ile Trp Gly Gln 
1               5               

<210> 10
<211> 8
<212> PRT
<213> Artificial Sequence

<223> "Cleavage after Gly4"

<220> 
<223> Cleavage after Gly4

<400> 10
Gly Asn Val Gly Leu Ala Gly Ala 
1               5               

<210> 11
<211> 6
<212> PRT
<213> Artificial Sequence

<223> "Cleavage after Gly4"

<220> 
<223> Cleavage after Gly4

<400> 11
Gly Pro Gln Gly Ile Ala 
1               5       

<210> 12
<211> 6
<212> PRT
<213> Artificial Sequence

<223> "Cleavage after Gly4"

<220> 
<223> Cleavage after Gly4

<400> 12
Gly Pro Gln Gly Ile Leu 
1               5       

<210> 13
<211> 6
<212> PRT
<213> Artificial Sequence

<223> "Cleveage after Gly4"

<220> 
<223> Cleveage after Gly4

<400> 13
Gly Pro Gln Gly Leu Ala 
1               5       

<210> 14
<211> 6
<212> PRT
<213> Artificial Sequence

<223> "Cleavage after Gly4"

<220> 
<223> Cleavage after Gly4

<400> 14
Gly Pro Gln Gly Leu Leu 
1               5       

<210> 15
<211> 6
<212> PRT
<213> Artificial Sequence

<223> "Cleavage after Gly4"

<220> 
<223> Cleavage after Gly4

<400> 15
Gly Pro Leu Gly Ile Ala 
1               5       

<210> 16
<211> 6
<212> PRT
<213> Artificial Sequence

<223> "Cleavage after Gly4"

<220> 
<223> Cleavage after Gly4

<400> 16
Gly Pro Leu Gly Ile Leu 
1               5       

<210> 17
<211> 6
<212> PRT
<213> Artificial Sequence

<223> "Cleavage after Gly4"

<220> 
<223> Cleavage after Gly4

<400> 17
Gly Pro Leu Gly Leu Ala 
1               5       

<210> 18
<211> 6
<212> PRT
<213> Artificial Sequence

<223> "Cleavage after Gly4"

<220> 
<223> Cleavage after Gly4

<400> 18
Gly Pro Leu Gly Leu Leu 
1               5       

<210> 19
<211> 6
<212> PRT
<213> Artificial Sequence

<223> "Cleavage after Gly4"

<220> 
<223> Cleavage after Gly4

<400> 19
Gly Pro Arg Gly Leu Gln 
1               5       

<210> 20
<211> 6
<212> PRT
<213> Artificial Sequence

<223> "Cleavage after Gly4"

<220> 
<223> Cleavage after Gly4

<400> 20
Gly Pro Thr Gly Leu Ala 
1               5       

<210> 21
<211> 15
<212> PRT
<213> Artificial Sequence

<223> "MMP-cleavable peptide"

<220> 
<223> MMP-cleavable peptide

<400> 21
Gly Pro Gln Gly Ile Ala Gly Gln Arg Gly Val Val Gly Leu Pro 
1               5                   10                  15  

<210> 22
<211> 15
<212> PRT
<213> Artificial Sequence

<223> "MMP-cleavable peptide"

<220> 
<223> MMP-cleavable peptide

<400> 22
Gly Pro Gln Gly Leu Leu Gly Ala Pro Gly Ile Leu Gly Leu Pro 
1               5                   10                  15  

<210> 23
<211> 9
<212> PRT
<213> Artificial Sequence

<223> "MMP-cleavable peptide"

<220> 
<223> MMP-cleavable peptide

<400> 23
Gly Glu Gln Gly Pro Gln Gly Leu Pro 
1               5                   

<210> 24
<211> 12
<212> PRT
<213> Artificial Sequence

<223> "MMP-cleavable peptide"

<220> 
<223> MMP-cleavable peptide

<400> 24
Gly Pro Gln Gly Leu Ala Gly Gln Arg Gly Ile Val 
1               5                   10          

<210> 25
<211> 35
<212> PRT
<213> Artificial Sequence

<223> "MMP-cleavable peptide"

<220> 
<223> MMP-cleavable peptide

<400> 25
Gly Ala Gln Gly Pro Pro Gly Ala Pro Gly Pro Leu Gly Ile Ala Gly 
1               5                   10                  15      
Ile Thr Gly Ala Arg Gly Leu Ala Gly Pro Pro Gly Met Pro Gly Pro 
            20                  25                  30          
Arg Gly Ser 
        35  

<210> 26
<211> 12
<212> PRT
<213> Artificial Sequence

<223> "MMP-cleavable peptide"

<220> 
<223> MMP-cleavable peptide

<400> 26
Gly Pro Leu Gly Ile Ala Gly Ile Thr Gly Ala Arg 
1               5                   10          

<210> 27
<211> 24
<212> PRT
<213> Artificial Sequence

<223> "MMP-cleavable peptide"

<220> 
<223> MMP-cleavable peptide

<400> 27
Gly Ala Gln Gly Pro Pro Gly Ala Pro Gly Pro Leu Gly Ile Ala Gly 
1               5                   10                  15      
Ile Thr Gly Ala Arg Gly Leu Ala 
            20                  

<210> 28
<211> 33
<212> PRT
<213> Artificial Sequence

<223> "MMP-cleavable peptide"

<220> 
<223> MMP-cleavable peptide

<400> 28
Gly Pro Ser Gly Ala Glu Gly Pro Pro Gly Pro Gln Gly Leu Ala Gly 
1               5                   10                  15      
Gln Arg Gly Ile Val Gly Leu Pro Gly Gln Arg Gly Glu Arg Gly Phe 
            20                  25                  30          
Pro 
    

<210> 29
<211> 12
<212> PRT
<213> Artificial Sequence

<223> "MMP-cleavable peptide"

<220> 
<223> MMP-cleavable peptide

<400> 29
Gly Pro Gln Gly Leu Ala Gly Gln Arg Gly Ile Val 
1               5                   10          

<210> 30
<211> 24
<212> PRT
<213> Artificial Sequence

<223> "MMP-cleavable peptide"

<220> 
<223> MMP-cleavable peptide

<400> 30
Gly Pro Ser Gly Ala Glu Gly Pro Pro Gly Pro Gln Gly Leu Ala Gly 
1               5                   10                  15      
Gln Arg Gly Ile Val Gly Leu Pro 
            20                  

<210> 31
<211> 6
<212> PRT
<213> Artificial Sequence

<223> "Integrin binding site"

<220> 
<223> Integrin binding site

<400> 31
Gly Phe Pro Gly Glu Arg 
1               5       

<210> 32
<211> 10
<212> PRT
<213> Artificial Sequence

<223> "Integrin binding site"

<220> 
<223> Integrin binding site

<400> 32
Gly Glu Phe Tyr Phe Asp Leu Arg Leu Lys 
1               5                   10  

<210> 33
<211> 5
<212> PRT
<213> Artificial Sequence

<223> "IKVAV motif"

<220> 
<223> IKVAV motif

<400> 33
Ile Lys Val Ala Val 
1               5   

<210> 34
<211> 18
<212> PRT
<213> Artificial Sequence

<223> "Fibronectin binding domain"

<220> 
<223> Fibronectin binding domain

<400> 34
Gly Leu Ala Gly Gln Arg Gly Ile Val Gly Leu Pro Gly Gln Arg Gly 
1               5                   10                  15      
Glu Arg 
        

<210> 35
<211> 12
<212> PRT
<213> Artificial Sequence

<223> "DDR2"

<220> 
<223> DDR2

<400> 35
Gly Pro Arg Gly Gln Pro Gly Val Met Gly Phe Pro 
1               5                   10          

<210> 36
<211> 6
<212> PRT
<213> Artificial Sequence

<223> "Collagen-like protein"

<220> 
<223> Collagen-like protein

<400> 36
Gly Ala Ala Val Met Gly 
1               5       

<210> 37
<211> 8
<212> PRT
<213> Artificial Sequence

<223> "Collagen-like protein"

<220> 
<223> Collagen-like protein

<400> 37
Gly Asp Ser Ala Val Ile Leu Gly 
1               5               

<210> 38
<211> 10
<212> PRT
<213> Artificial Sequence

<223> "Collagen-like protein"

<220> 
<223> Collagen-like protein

<400> 38
Gly Asp Met Val Val Ser Arg Val Lys Gly 
1               5                   10  

<210> 39
<211> 14
<212> PRT
<213> Artificial Sequence

<223> "Collagen-like protein"

<220> 
<223> Collagen-like protein

<400> 39
Gly Arg Leu Val Asp Thr Gly Pro Gly Ala Arg Glu Lys Gly 
1               5                   10                  

<210> 40
<211> 43
<212> PRT
<213> Artificial Sequence

<223> "Collagen-like protein"

<220> 
<223> Collagen-like protein

<400> 40
Gly Ser Val Pro Asn Val Asp Arg Leu Leu Glu Thr Ala Gly Ile Lys 
1               5                   10                  15      
Ala Ser Ala Leu Arg Glu Ile Val Glu Thr Trp Asp Glu Ser Ser Gly 
            20                  25                  30          
Ser Phe Leu Pro Val Pro Glu Arg Arg Arg Gly 
        35                  40              

<210> 41
<211> 15
<212> PRT
<213> Artificial Sequence

<223> "Collagen-like protein"

<220> 
<223> Collagen-like protein

<400> 41
Gly Pro Gly Glu Phe Tyr Phe Asp Leu Arg Leu Lys Gly Pro Gly 
1               5                   10                  15  

<210> 42
<211> 16
<212> PRT
<213> Artificial Sequence

<223> "Collagen-like protein"

<220> 
<223> Collagen-like protein

<400> 42
Gly Gln Ile Ser Glu Gln Lys Arg Pro Ile Asp Val Glu Phe Gln Lys 
1               5                   10                  15      



<210> 43
<211> 6
<212> PRT
<213> Artificial Sequence

<223> "1beta-integrin binding domain"

<220> 
<223> 1beta-integrin binding domain

<400> 43
Gly Leu Pro Gly Glu Arg 
1               5       

<210> 44
<211> 6
<212> PRT
<213> Artificial Sequence

<223> "1beta-integrin binding domain"

<220> 
<223> 1beta-integrin binding domain

<400> 44
Gly Phe Pro Gly Glu Arg 
1               5       

<210> 45
<211> 6
<212> PRT
<213> Artificial Sequence

<223> "1beta-integrin binding domain"

<220> 
<223> 1beta-integrin binding domain

<400> 45
Gly Phe Pro Gly Glu Asn 
1               5       

<210> 46
<211> 16
<212> PRT
<213> Artificial Sequence

<223> "ECM retaining moiety"

<220> 
<223> ECM retaining moiety

<400> 46
Asp His Leu Ser Asp Asn Tyr Thr Leu Asp His Asp Arg Ala Ile His 
1               5                   10                  15      



