                         SEQUENCE LISTING

<110>  Technische Universitt Dresden
 
<120>  A delivery system for targeted delivery of a therapeutically 
       active payload

<130>  TUD112WO

<150>  EP 16 196 144.6-1453
<151>  2016-10-28

<160>  33    

<170>  PatentIn version 3.5

<210>  1
<211>  464
<212>  PRT
<213>  Mus musculus

<400>  1

Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly Asp Ala Ala Gln Pro Ala Arg Arg Ala Arg Arg Thr 
            20                  25                  30          


Lys Leu Gly Thr Glu Leu Gly Ser Gln Val Lys Leu Gln Glu Ser Gly 
        35                  40                  45              


Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Lys Leu Ser Cys Val Ala 
    50                  55                  60                  


Ser Gly Phe Thr Phe Ser Ser Tyr Thr Met Ser Trp Val Arg Arg Thr 
65                  70                  75                  80  


Pro Glu Lys Arg Leu Glu Trp Val Ala Tyr Ile His Asn Gly Gly Gly 
                85                  90                  95      


His Thr Tyr Tyr Pro Asp Thr Ile Lys Gly Arg Phe Thr Ile Ser Arg 
            100                 105                 110         


Asp Asn Ala Lys Asn Thr Leu Phe Leu Glu Met Ser Ser Leu Lys Ser 
        115                 120                 125             


Glu Asp Thr Ala Met Tyr Tyr Cys Thr Arg Arg Met Tyr Tyr Gly Asn 
    130                 135                 140                 


Ser His Trp Tyr Phe Asp Val Trp Gly Ala Gly Thr Ser Val Thr Val 
145                 150                 155                 160 


Ser Ser Ala Lys Thr Thr Pro Pro Ser Val Tyr Gly Gly Gly Gly Ser 
                165                 170                 175     


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Thr Asn Ser Asp Ile Val 
            180                 185                 190         


Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Leu Gly Asp Arg Val 
        195                 200                 205             


Thr Ile Asn Cys Arg Thr Ser Gln Asp Ile Ser Asn Tyr Leu Asn Trp 
    210                 215                 220                 


Tyr Gln Leu Thr Pro Asp Gly Thr Val Lys Leu Leu Ile Tyr Tyr Thr 
225                 230                 235                 240 


Leu Lys Leu Asn Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser 
                245                 250                 255     


Gly Thr Asp Tyr Ser Leu Thr Ile Asn Asn Leu Glu Lys Glu Asp Phe 
            260                 265                 270         


Ala Thr Tyr Phe Cys Gln Gln Ser Lys Thr Leu Pro Trp Thr Phe Gly 
        275                 280                 285             


Gly Gly Thr Lys Leu Glu Ile Lys Arg Ala Asp Ala Ala Pro Thr Val 
    290                 295                 300                 


Ser Gly Pro Lys Leu Ser Ser Lys Leu Lys Val Thr Val Asn Gly Thr 
305                 310                 315                 320 


Ala Tyr Asp Val Asp Val Asp Val Asp Lys Ser His Glu Asn Pro Met 
                325                 330                 335     


Gly Thr Ile Leu Phe Gly Gly Gly Thr Gly Gly Ala Pro Ala Pro Ala 
            340                 345                 350         


Ala Gly Gly Ala Gly Ala Gly Lys Ala Gly Glu Gly Glu Ile Pro Ala 
        355                 360                 365             


Pro Leu Ala Gly Thr Val Ser Lys Ile Leu Val Lys Glu Gly Asp Thr 
    370                 375                 380                 


Val Lys Ala Gly Gln Thr Val Leu Val Leu Glu Ala Met Lys Met Glu 
385                 390                 395                 400 


Thr Glu Ile Asn Ala Pro Thr Asp Gly Lys Val Glu Lys Val Leu Val 
                405                 410                 415     


Lys Glu Arg Asp Ala Val Gln Gly Gly Gln Gly Leu Ile Lys Ile Gly 
            420                 425                 430         


Asp Leu Glu Leu Ile Glu Gly Ser Ser Gly Pro Glu Gln Lys Leu Ile 
        435                 440                 445             


Ser Glu Glu Asp Leu Asn Ser Ala Val Asp His His His His His His 
    450                 455                 460                 


<210>  2
<211>  350
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Humanized antibody

<400>  2

Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly Asp Ala Ala Gln Pro Ala Arg Arg Ala Arg Arg Thr 
            20                  25                  30          


Lys Leu Gly Thr Glu Leu Gly Ser Glu Val Gln Leu Leu Glu Ser Gly 
        35                  40                  45              


Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Val Ala 
    50                  55                  60                  


Ser Gly Phe Thr Phe Ser Ser Tyr Thr Met Ser Trp Val Arg Gln Ala 
65                  70                  75                  80  


Pro Gly Lys Gly Leu Glu Trp Val Ser Tyr Ile His Asn Gly Gly Gly 
                85                  90                  95      


His Thr Tyr Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg 
            100                 105                 110         


Asp Asn Ser Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala 
        115                 120                 125             


Glu Asp Thr Ala Val Tyr Tyr Cys Thr Arg Arg Met Tyr Tyr Gly Asn 
    130                 135                 140                 


Ser His Trp Tyr Phe Asp Val Trp Gly Ala Gly Thr Arg Val Thr Ile 
145                 150                 155                 160 


Thr Ser Ala Lys Thr Thr Pro Pro Ser Val Tyr Gly Gly Gly Gly Ser 
                165                 170                 175     


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Thr Asn Ser Asp Ile Gln 
            180                 185                 190         


Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val 
        195                 200                 205             


Thr Ile Thr Cys Arg Thr Ser Gln Ser Ile Ser Asn Tyr Leu Asn Trp 
    210                 215                 220                 


Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Tyr Thr 
225                 230                 235                 240 


Leu Lys Leu Asn Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser 
                245                 250                 255     


Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe 
            260                 265                 270         


Ala Thr Tyr Tyr Cys Gln Gln Ser Lys Thr Leu Pro Trp Thr Phe Gly 
        275                 280                 285             


Gly Gly Thr Lys Leu Glu Ile Lys Arg Ala Asp Ala Ala Pro Thr Val 
    290                 295                 300                 


Ser Gly Pro Glu Gln Lys Leu Ile Ser Glu Glu Asp Leu Asn Ser Ala 
305                 310                 315                 320 


Val Asp Met Ser Gly Leu Asn Asp Ile Phe Glu Ala Gln Lys Ile Glu 
                325                 330                 335     


Trp His Glu Gly Ala Pro Ser Ser His His His His His His 
            340                 345                 350 


<210>  3
<211>  441
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Single chain antibody fragment

<400>  3

Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly Asp Ala Ala Gln Pro Ala Arg Arg Ala Arg Arg Thr 
            20                  25                  30          


Lys Leu Gly Thr Glu Leu Gly Ser His Met Gln Val Lys Leu Gln Gln 
        35                  40                  45              


Ser Gly Gly Gly Leu Val Lys Pro Gly Ala Ser Leu Lys Leu Ser Cys 
    50                  55                  60                  


Val Thr Ser Gly Phe Thr Phe Arg Lys Phe Gly Met Ser Trp Val Arg 
65                  70                  75                  80  


Gln Thr Ser Asp Lys Arg Leu Glu Trp Val Ala Ser Ile Ser Thr Gly 
                85                  90                  95      


Gly Tyr Asn Thr Tyr Tyr Ser Asp Asn Val Lys Gly Arg Phe Thr Ile 
            100                 105                 110         


Ser Arg Glu Asn Ala Lys Asn Thr Leu Tyr Leu Gln Met Ser Ser Leu 
        115                 120                 125             


Lys Ser Glu Asp Thr Ala Leu Tyr Tyr Cys Thr Arg Gly Tyr Ser Pro 
    130                 135                 140                 


Tyr Ser Tyr Ala Met Asp Tyr Trp Gly Gln Gly Thr Thr Val Thr Val 
145                 150                 155                 160 


Ser Ser Ser Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
                165                 170                 175     


Ser Asp Ile Glu Leu Thr Gln Ser Pro Ala Ser Leu Ser Val Ala Thr 
            180                 185                 190         


Gly Glu Lys Ala Thr Ile Arg Cys Met Thr Ser Thr Asp Ile Asp Asp 
        195                 200                 205             


Asp Met Asn Trp Tyr Gln Gln Lys Pro Gly Glu Pro Pro Lys Phe Leu 
    210                 215                 220                 


Ile Ser Glu Gly Asn Thr Leu Arg Pro Gly Val Pro Ser Arg Phe Ser 
225                 230                 235                 240 


Ser Ser Gly Thr Gly Thr Asp Phe Val Phe Thr Ile Glu Asn Thr Leu 
                245                 250                 255     


Ser Glu Asp Val Gly Asp Tyr Tyr Cys Leu Gln Ser Trp Asn Val Pro 
            260                 265                 270         


Leu Thr Phe Gly Asp Gly Thr Lys Leu Glu Ile Thr Lys Leu Ser Ser 
        275                 280                 285             


Lys Leu Lys Val Thr Val Asn Gly Thr Ala Tyr Asp Val Asp Val Asp 
    290                 295                 300                 


Val Asp Lys Ser His Glu Asn Pro Met Gly Thr Ile Leu Phe Gly Gly 
305                 310                 315                 320 


Gly Thr Gly Gly Ala Pro Ala Pro Ala Ala Gly Gly Ala Gly Ala Gly 
                325                 330                 335     


Lys Ala Gly Glu Gly Glu Ile Pro Ala Pro Leu Ala Gly Thr Val Ser 
            340                 345                 350         


Lys Ile Leu Val Lys Glu Gly Asp Thr Val Lys Ala Gly Gln Thr Val 
        355                 360                 365             


Leu Val Leu Glu Ala Met Lys Met Glu Thr Glu Ile Asn Ala Pro Thr 
    370                 375                 380                 


Asp Gly Lys Val Glu Lys Val Leu Val Lys Glu Arg Asp Ala Val Gln 
385                 390                 395                 400 


Gly Gly Gln Gly Leu Ile Lys Ile Gly Asp Leu Glu Leu Ile Glu Gly 
                405                 410                 415     


Ser Ser Gly Pro Glu Gln Lys Leu Ile Ser Glu Glu Asp Leu Asn Ser 
            420                 425                 430         


Ala Val Asp His His His His His His 
        435                 440     


<210>  4
<211>  336
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Antibody single chain fragment

<400>  4

Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly Asp Ala Ala Gln Pro Ala Arg Arg Ala Arg Arg Thr 
            20                  25                  30          


Lys Leu Gly Thr Glu Leu Gly Ser His Met Gln Val Lys Leu Gln Gln 
        35                  40                  45              


Ser Gly Gly Gly Leu Val Lys Pro Gly Ala Ser Leu Lys Leu Ser Cys 
    50                  55                  60                  


Val Thr Ser Gly Phe Thr Phe Arg Lys Phe Gly Met Ser Trp Val Arg 
65                  70                  75                  80  


Gln Thr Ser Asp Lys Arg Leu Glu Trp Val Ala Ser Ile Ser Thr Gly 
                85                  90                  95      


Gly Tyr Asn Thr Tyr Tyr Ser Asp Asn Val Lys Gly Arg Phe Thr Ile 
            100                 105                 110         


Ser Arg Glu Asn Ala Lys Asn Thr Leu Tyr Leu Gln Met Ser Ser Leu 
        115                 120                 125             


Lys Ser Glu Asp Thr Ala Leu Tyr Tyr Cys Thr Arg Gly Tyr Ser Pro 
    130                 135                 140                 


Tyr Ser Tyr Ala Met Asp Tyr Trp Gly Gln Gly Thr Thr Val Thr Val 
145                 150                 155                 160 


Ser Ser Ser Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
                165                 170                 175     


Ser Asp Ile Glu Leu Thr Gln Ser Pro Ala Ser Leu Ser Val Ala Thr 
            180                 185                 190         


Gly Glu Lys Ala Thr Ile Arg Cys Met Thr Ser Thr Asp Ile Asp Asp 
        195                 200                 205             


Asp Met Asn Trp Tyr Gln Gln Lys Pro Gly Glu Pro Pro Lys Phe Leu 
    210                 215                 220                 


Ile Ser Glu Gly Asn Thr Leu Arg Pro Gly Val Pro Ser Arg Phe Ser 
225                 230                 235                 240 


Ser Ser Gly Thr Gly Thr Asp Phe Val Phe Thr Ile Glu Asn Thr Leu 
                245                 250                 255     


Ser Glu Asp Val Gly Asp Tyr Tyr Cys Leu Gln Ser Trp Asn Val Pro 
            260                 265                 270         


Leu Thr Phe Gly Asp Gly Thr Lys Leu Glu Ile Thr Met Ser Gly Leu 
        275                 280                 285             


Asn Asp Ile Phe Glu Ala Gln Lys Ile Glu Trp His Glu Gly Ala Pro 
    290                 295                 300                 


Ser Ser Gly Gly Glu Ser Ser Gly Ser Gly Pro Glu Gln Lys Leu Ile 
305                 310                 315                 320 


Ser Glu Glu Asp Leu Asn Ser Ala Val Asp His His His His His His 
                325                 330                 335     


<210>  5
<211>  126
<212>  PRT
<213>  Artificial sequence

<220>
<223>  transcarboxylase fragment

<400>  5

Met Lys Leu Lys Val Thr Val Asn Gly Thr Ala Tyr Asp Val Asp Val 
1               5                   10                  15      


Asp Val Asp Lys Ser His Glu Asn Pro Met Gly Thr Ile Leu Phe Gly 
            20                  25                  30          


Gly Gly Thr Gly Gly Ala Pro Ala Pro Ala Ala Gly Gly Ala Gly Ala 
        35                  40                  45              


Gly Lys Ala Gly Glu Gly Glu Ile Pro Ala Pro Leu Ala Gly Thr Val 
    50                  55                  60                  


Ser Lys Ile Leu Val Lys Glu Gly Asp Thr Val Lys Ala Gly Gln Thr 
65                  70                  75                  80  


Val Leu Val Leu Glu Ala Met Lys Met Glu Thr Glu Ile Asn Ala Pro 
                85                  90                  95      


Thr Asp Gly Lys Val Glu Lys Val Leu Val Lys Glu Arg Asp Ala Val 
            100                 105                 110         


Gln Gly Gly Gln Gly Leu Ile Lys Ile Gly Asp Leu Glu Leu 
        115                 120                 125     


<210>  6
<211>  68
<212>  PRT
<213>  Artificial sequence

<220>
<223>  BCCP domain

<400>  6

Val Leu Arg Ser Pro Met Pro Gly Val Val Val Ala Val Ser Val Lys 
1               5                   10                  15      


Pro Gly Asp Ala Val Ala Glu Gly Gln Glu Ile Cys Val Ile Glu Ala 
            20                  25                  30          


Met Lys Met Gln Asn Ser Met Thr Ala Gly Lys Thr Gly Thr Val Lys 
        35                  40                  45              


Ser Val His Cys Gln Ala Gly Asp Thr Val Gly Glu Gly Asp Leu Leu 
    50                  55                  60                  


Val Glu Leu Glu 
65              


<210>  7
<211>  13
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic peptide


<220>
<221>  VARIANT
<222>  (2)..(2)
<223>  Xaa is any amino acid

<220>
<221>  VARIANT
<222>  (3)..(3)
<223>  Xaa is any amino acid except Leu, Val, Ile, Trp, Phe or Tyr

<400>  7

Leu Xaa Xaa Ile Phe Glu Ala Gln Lys Ile Glu Trp Arg 
1               5                   10              


<210>  8
<211>  15
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic peptide

<400>  8

Gly Leu Asn Asp Ile Phe Glu Ala Gln Lys Ile Glu Trp His Glu 
1               5                   10                  15  


<210>  9
<211>  15
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic peptide

<400>  9

Ala Leu Asn Asp Ile Phe Glu Ala Gln Lys Ile Glu Trp His Ala 
1               5                   10                  15  


<210>  10
<211>  23
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic peptide

<400>  10

Met Ala Gly Gly Leu Asn Asp Ile Phe Glu Ala Gln Lys Ile Glu Trp 
1               5                   10                  15      


His Glu Asp Thr Gly Gly Ser 
            20              


<210>  11
<211>  23
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic peptide

<400>  11

Met Ser Gly Leu Asn Asp Ile Phe Glu Ala Gln Lys Ile Glu Trp His 
1               5                   10                  15      


Glu Gly Ala Pro Ser Ser Arg 
            20              


<210>  12
<211>  15
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synbthetic peptide

<400>  12

Leu His His Ile Leu Asp Ala Gln Lys Met Val Trp Asn His Arg 
1               5                   10                  15  


<210>  13
<211>  10
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic peptide

<400>  13

Glu Gln Lys Leu Ile Ser Glu Glu Asp Leu 
1               5                   10  


<210>  14
<211>  21
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic oligonucleotide

<400>  14
gaauuaaccc uuggugaaut t                                                 21


<210>  15
<211>  21
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic oligonucleotide

<400>  15
auucaccaag gguuaauuct t                                                 21


<210>  16
<211>  21
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic oligonucleotide

<400>  16
gaaggauaag uacacgcugt t                                                 21


<210>  17
<211>  21
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic oligonucleotide

<400>  17
cagcguguac uuauccuuct t                                                 21


<210>  18
<211>  21
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic oligonucleotide

<400>  18
cugccgagaa uccauguaut t                                                 21


<210>  19
<211>  21
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic oligonucleotide

<400>  19
auacauggau ucucggcagt t                                                 21


<210>  20
<211>  21
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic oligonucleotide

<400>  20
cgagaccuau cgccgcaucg t                                                 21


<210>  21
<211>  21
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic oligonucleotide

<400>  21
gaugcggcga uaggucucgg t                                                 21


<210>  22
<211>  21
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic oligonucleotide

<400>  22
ggauggccca gaaggagaat t                                                 21


<210>  23
<211>  21
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic oligonucleotide

<400>  23
uucuccuucu gggccaucct t                                                 21


<210>  24
<211>  21
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic oligonucleotide

<400>  24
gaagcagauu gagcagaagt t                                                 21


<210>  25
<211>  21
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic oligonucleotide

<400>  25
cuucugcuca aucugcuuct t                                                 21


<210>  26
<211>  1119
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide

<400>  26
atggagacag acacactcct gctatgggta ctgctgctct gggttccagg ttccactggt       60

gacatgaaag acaacactgt cccactcaaa ctgatagctt tgctcgccaa tggagagttc      120

catagcgggg aacagttggg tgaaacctta ggcatgtctc gcgctgccat caataagcac      180

atacagacct tgcgagattg gggagtggac gtgtttacag tcccaggaaa agggtattcc      240

cttccggaac ccattcagct tctaaacgcc aagcagatac tgggccagct tgatggtggc      300

tcagttgccg ttctgcccgt aatagatagc accaatcagt atctcctcga tcgcattggc      360

gaactgaaga gtggagatgc ctgcattgcc gagtatcagc aagccggaag agggaggaga      420

gggaggaagt ggtttagccc ttttggggcc aatctctacc tcagcatgtt ttggcggtta      480

gagcagggac cagctgccgc gattgggctg tctctggtga tcggcattgt gatggcggaa      540

gttctgcgca aactcggggc tgacaaagta cgggtcaagt ggcctaatga cctgtactta      600

caggaccgaa agctggccgg aatccttgtc gagctaacag gcaaaactgg cgatgctgca      660

cagatcgtga ttggtgcagg tatcaacatg gctatgaggc gcgtggaaga gtctgtggtg      720

aaccaaggct ggatcacgtt gcaggaagca ggcatcaacc tggatcgtaa cacattggcg      780

gctatgctga tcagagagct tcgtgctgca cttgagctgt tcgaacagga gggactggca      840

ccctacctat ccaggtggga aaagctggac aacttcatca atagacctgt gaagctcatc      900

attggggaca aggagatttt cggcataagt cggggtattg acaagcaagg agccctgctg      960

ttggagcaag acggcatcat caaaccctgg atgggtggcg agatttccct gcggtcagca     1020

gagaaataca ctgatatcga aatgaaccgc ctgggtaagg gcggaggagg cgattataaa     1080

gatgatgatg ataaagggcg gccgccaata aatcgataa                            1119


<210>  27
<211>  372
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Recombinant polypeptide

<400>  27

Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly Asp Met Lys Asp Asn Thr Val Pro Leu Lys Leu Ile 
            20                  25                  30          


Ala Leu Leu Ala Asn Gly Glu Phe His Ser Gly Glu Gln Leu Gly Glu 
        35                  40                  45              


Thr Leu Gly Met Ser Arg Ala Ala Ile Asn Lys His Ile Gln Thr Leu 
    50                  55                  60                  


Arg Asp Trp Gly Val Asp Val Phe Thr Val Pro Gly Lys Gly Tyr Ser 
65                  70                  75                  80  


Leu Pro Glu Pro Ile Gln Leu Leu Asn Ala Lys Gln Ile Leu Gly Gln 
                85                  90                  95      


Leu Asp Gly Gly Ser Val Ala Val Leu Pro Val Ile Asp Ser Thr Asn 
            100                 105                 110         


Gln Tyr Leu Leu Asp Arg Ile Gly Glu Leu Lys Ser Gly Asp Ala Cys 
        115                 120                 125             


Ile Ala Glu Tyr Gln Gln Ala Gly Arg Gly Arg Arg Gly Arg Lys Trp 
    130                 135                 140                 


Phe Ser Pro Phe Gly Ala Asn Leu Tyr Leu Ser Met Phe Trp Arg Leu 
145                 150                 155                 160 


Glu Gln Gly Pro Ala Ala Ala Ile Gly Leu Ser Leu Val Ile Gly Ile 
                165                 170                 175     


Val Met Ala Glu Val Leu Arg Lys Leu Gly Ala Asp Lys Val Arg Val 
            180                 185                 190         


Lys Trp Pro Asn Asp Leu Tyr Leu Gln Asp Arg Lys Leu Ala Gly Ile 
        195                 200                 205             


Leu Val Glu Leu Thr Gly Lys Thr Gly Asp Ala Ala Gln Ile Val Ile 
    210                 215                 220                 


Gly Ala Gly Ile Asn Met Ala Met Arg Arg Val Glu Glu Ser Val Val 
225                 230                 235                 240 


Asn Gln Gly Trp Ile Thr Leu Gln Glu Ala Gly Ile Asn Leu Asp Arg 
                245                 250                 255     


Asn Thr Leu Ala Ala Met Leu Ile Arg Glu Leu Arg Ala Ala Leu Glu 
            260                 265                 270         


Leu Phe Glu Gln Glu Gly Leu Ala Pro Tyr Leu Ser Arg Trp Glu Lys 
        275                 280                 285             


Leu Asp Asn Phe Ile Asn Arg Pro Val Lys Leu Ile Ile Gly Asp Lys 
    290                 295                 300                 


Glu Ile Phe Gly Ile Ser Arg Gly Ile Asp Lys Gln Gly Ala Leu Leu 
305                 310                 315                 320 


Leu Glu Gln Asp Gly Ile Ile Lys Pro Trp Met Gly Gly Glu Ile Ser 
                325                 330                 335     


Leu Arg Ser Ala Glu Lys Tyr Thr Asp Ile Glu Met Asn Arg Leu Gly 
            340                 345                 350         


Lys Gly Gly Gly Gly Asp Tyr Lys Asp Asp Asp Asp Lys Gly Arg Pro 
        355                 360                 365             


Pro Ile Asn Arg 
    370         


<210>  28
<211>  21
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic oligonucleotide

<400>  28
cuuacgcuga guacuucgat t                                                 21


<210>  29
<211>  21
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic oligonucleotide

<400>  29
ggcgcgccac uucuaaauat t                                                 21


<210>  30
<211>  332
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Recombinant polypeptide

<400>  30

Met Lys Asp Asn Thr Val Pro Leu Lys Leu Ile Ala Leu Leu Ala Asn 
1               5                   10                  15      


Gly Glu Phe His Ser Gly Glu Gln Leu Gly Glu Thr Leu Gly Met Ser 
            20                  25                  30          


Arg Ala Ala Ile Asn Lys His Ile Gln Thr Leu Arg Asp Trp Gly Val 
        35                  40                  45              


Asp Val Phe Thr Val Pro Gly Lys Gly Tyr Ser Leu Pro Glu Pro Ile 
    50                  55                  60                  


Gln Leu Leu Asn Ala Lys Gln Ile Leu Gly Gln Leu Asp Gly Gly Ser 
65                  70                  75                  80  


Val Ala Val Leu Pro Val Ile Asp Ser Thr Asn Gln Tyr Leu Leu Asp 
                85                  90                  95      


Arg Ile Gly Glu Leu Lys Ser Gly Asp Ala Cys Ile Ala Glu Tyr Gln 
            100                 105                 110         


Gln Ala Gly Arg Gly Arg Arg Gly Arg Lys Trp Phe Ser Pro Phe Gly 
        115                 120                 125             


Ala Asn Leu Tyr Leu Ser Met Phe Trp Arg Leu Glu Gln Gly Pro Ala 
    130                 135                 140                 


Ala Ala Ile Gly Leu Ser Leu Val Ile Gly Ile Val Met Ala Glu Val 
145                 150                 155                 160 


Leu Arg Lys Leu Gly Ala Asp Lys Val Arg Val Lys Trp Pro Asn Asp 
                165                 170                 175     


Leu Tyr Leu Gln Asp Arg Lys Leu Ala Gly Ile Leu Val Glu Leu Thr 
            180                 185                 190         


Gly Lys Thr Gly Asp Ala Ala Gln Ile Val Ile Gly Ala Gly Ile Asn 
        195                 200                 205             


Met Ala Met Arg Arg Val Glu Glu Ser Val Val Asn Gln Gly Trp Ile 
    210                 215                 220                 


Thr Leu Gln Glu Ala Gly Ile Asn Leu Asp Arg Asn Thr Leu Ala Ala 
225                 230                 235                 240 


Met Leu Ile Arg Glu Leu Arg Ala Ala Leu Glu Leu Phe Glu Gln Glu 
                245                 250                 255     


Gly Leu Ala Pro Tyr Leu Ser Arg Trp Glu Lys Leu Asp Asn Phe Ile 
            260                 265                 270         


Asn Arg Pro Val Lys Leu Ile Ile Gly Asp Lys Glu Ile Phe Gly Ile 
        275                 280                 285             


Ser Arg Gly Ile Asp Lys Gln Gly Ala Leu Leu Leu Glu Gln Asp Gly 
    290                 295                 300                 


Ile Ile Lys Pro Trp Met Gly Gly Glu Ile Ser Leu Arg Ser Ala Glu 
305                 310                 315                 320 


Lys Tyr Thr Asp Ile Glu Met Asn Arg Leu Gly Lys 
                325                 330         


<210>  31
<211>  47
<212>  DNA
<213>  Artificial sequence

<220>
<223>  PCR primer

<400>  31
tttttgggcc caagctttcg tcgaaactga aggtaacagt caacggc                     47


<210>  32
<211>  42
<212>  DNA
<213>  Artificial sequence

<220>
<223>  PCR primer

<400>  32
aaaaagggcc ccgacgaacc ttcgatgagc tcgagatccc cg                          42


<210>  33
<211>  23
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic peptide

<400>  33

Met Ser Gly Leu Asn Asp Ile Phe Glu Ala Gln Lys Ile Glu Trp His 
1               5                   10                  15      


Glu Gly Ala Pro Ser Ser Gly 
            20              


