                         SEQUENCE LISTING

<110>  DSM IP ASSETS B.V.
 
<120>  GERANYLGERANYL PYROPHOSPHATE SYNTHASES

<130>  32211-WO-PCT

<160>  33    

<170>  PatentIn version 3.5

<210>  1
<211>  327
<212>  PRT
<213>  Yarrowia lipolytica

<400>  1

Met Asp Tyr Asn Ser Ala Asp Phe Lys Glu Ile Trp Gly Lys Ala Ala 
1               5                   10                  15      


Asp Thr Ala Leu Leu Gly Pro Tyr Asn Tyr Leu Ala Asn Asn Arg Gly 
            20                  25                  30          


His Asn Ile Arg Glu His Leu Ile Ala Ala Phe Gly Ala Val Ile Lys 
        35                  40                  45              


Val Asp Lys Ser Asp Leu Glu Thr Ile Ser His Ile Thr Lys Ile Leu 
    50                  55                  60                  


His Asn Ser Ser Leu Leu Val Asp Asp Val Glu Asp Asn Ser Met Leu 
65                  70                  75                  80  


Arg Arg Gly Leu Pro Ala Ala His Cys Leu Phe Gly Val Pro Gln Thr 
                85                  90                  95      


Ile Asn Ser Ala Asn Tyr Met Tyr Phe Val Ala Leu Gln Glu Val Leu 
            100                 105                 110         


Lys Leu Lys Ser Tyr Asp Ala Val Ser Ile Phe Thr Glu Glu Met Ile 
        115                 120                 125             


Asn Leu His Arg Gly Gln Gly Met Asp Leu Tyr Trp Arg Glu Thr Leu 
    130                 135                 140                 


Thr Cys Pro Ser Glu Asp Glu Tyr Leu Glu Met Val Val His Lys Thr 
145                 150                 155                 160 


Gly Gly Leu Phe Arg Leu Ala Leu Arg Leu Met Leu Ser Val Ala Ser 
                165                 170                 175     


Lys Gln Glu Asp His Glu Lys Ile Asn Phe Asp Leu Thr His Leu Thr 
            180                 185                 190         


Asp Thr Leu Gly Val Ile Tyr Gln Ile Leu Asp Asp Tyr Leu Asn Leu 
        195                 200                 205             


Gln Ser Thr Glu Leu Thr Glu Asn Lys Gly Phe Cys Glu Asp Ile Ser 
    210                 215                 220                 


Glu Gly Lys Phe Ser Phe Pro Leu Ile His Ser Ile Arg Thr Asn Pro 
225                 230                 235                 240 


Asp Asn His Glu Ile Leu Asn Ile Leu Lys Gln Arg Thr Ser Asp Ala 
                245                 250                 255     


Ser Leu Lys Lys Tyr Ala Val Asp Tyr Met Arg Thr Glu Thr Lys Ser 
            260                 265                 270         


Phe Asp Tyr Cys Leu Lys Arg Ile Gln Ala Met Ser Leu Lys Ala Ser 
        275                 280                 285             


Ser Tyr Ile Asp Asp Leu Ala Ala Ala Gly His Asp Val Ser Lys Leu 
    290                 295                 300                 


Arg Ala Ile Leu His Tyr Phe Val Ser Thr Ser Asp Cys Glu Glu Arg 
305                 310                 315                 320 


Lys Tyr Phe Glu Asp Ala Gln 
                325         


<210>  2
<211>  984
<212>  DNA
<213>  Yarrowia lipolytica

<400>  2
atggattata acagcgcgga tttcaaggag atctggggca aggccgccga caccgcgctg       60

ctgggaccgt acaactacct cgccaacaac cggggccaca acatcagaga acacttgatc      120

gcagcgttcg gagcggttat caaggtggac aagagcgatc tcgaaaccat ttcgcacatc      180

accaagattt tgcataactc gtcgctgctt gttgatgacg tggaagacaa ctcgatgctc      240

cgacgaggcc tgccggcagc ccattgtctg tttggagtcc cccaaaccat caactccgcc      300

aactacatgt actttgtggc tctgcaggag gtgctcaagc tcaagtctta tgatgccgtc      360

tccattttca ccgaggaaat gatcaacttg catagaggtc agggtatgga tctctactgg      420

agagaaacac tcacttgccc ctcggaagac gagtatctgg agatggtggt gcacaagacc      480

ggaggactgt ttcggctggc tctgagactt atgctgtcgg tggcatcgaa acaggaggac      540

catgaaaaga tcaactttga tctcacacac cttaccgaca cactgggagt catttaccag      600

attctggatg attacctcaa cctgcagtcc acggaattga ccgagaacaa gggattctgc      660

gaagatatca gcgaaggaaa gttttcgttt ccgctgattc acagcatccg gaccaacccg      720

gataaccacg agattctcaa cattctcaaa cagcgaacaa gcgacgcttc actcaaaaag      780

tacgccgtgg actacatgag aacagaaacc aagagtttcg actactgcct caagagaatc      840

caggccatgt cactcaaggc aagttcgtac attgatgatc tcgcagcagc cggccacgat      900

gtctccaagt tgcgagccat tttgcattat tttgtgtcca cctctgactg tgaggagaga      960

aagtactttg aggatgcgca gtaa                                             984


<210>  3
<211>  327
<212>  PRT
<213>  Artificial sequence

<220>
<223>  GGS variant

<400>  3

Met Asp Tyr Asn Ser Ala Asp Phe Lys Glu Ile Trp Gly Lys Ala Ala 
1               5                   10                  15      


Asp Thr Ala Leu Leu Gly Pro Tyr Asn Tyr Leu Ala Asn Asn Arg Gly 
            20                  25                  30          


His Asn Ile Arg Glu His Leu Ile Ala Ala Phe Gly Ala Val Ile Lys 
        35                  40                  45              


Val Asp Lys Ser Asp Leu Glu Thr Ile Ser His Ile Thr Lys Ile Leu 
    50                  55                  60                  


His Asn Ser Ser Leu Leu Val Asp Asp Val Glu Asp Asn Ser Met Leu 
65                  70                  75                  80  


Arg Arg Gly Leu Pro Ala Ala His Cys Leu Phe Glu Val Pro Gln Thr 
                85                  90                  95      


Ile Asn Ser Ala Asn Tyr Met Tyr Phe Val Ala Leu Gln Glu Val Leu 
            100                 105                 110         


Lys Leu Lys Ser Tyr Asp Ala Val Ser Ile Phe Thr Glu Glu Met Ile 
        115                 120                 125             


Asn Leu His Arg Gly Gln Gly Met Asp Leu Tyr Trp Arg Glu Thr Leu 
    130                 135                 140                 


Thr Cys Pro Ser Glu Asp Glu Tyr Leu Glu Met Val Val His Lys Thr 
145                 150                 155                 160 


Gly Gly Leu Phe Arg Leu Ala Leu Arg Leu Met Leu Ser Val Ala Ser 
                165                 170                 175     


Lys Gln Glu Asp His Glu Lys Ile Asn Phe Asp Leu Thr His Leu Thr 
            180                 185                 190         


Asp Thr Leu Gly Val Ile Tyr Gln Ile Leu Asp Asp Tyr Leu Asn Leu 
        195                 200                 205             


Gln Ser Thr Glu Leu Thr Glu Asn Lys Gly Phe Cys Glu Asp Ile Ser 
    210                 215                 220                 


Glu Gly Lys Phe Ser Phe Pro Leu Ile His Ser Ile Arg Thr Asn Pro 
225                 230                 235                 240 


Asp Asn His Glu Ile Leu Asn Ile Leu Lys Gln Arg Thr Ser Asp Ala 
                245                 250                 255     


Ser Leu Lys Lys Tyr Ala Val Asp Tyr Met Arg Thr Glu Thr Lys Ser 
            260                 265                 270         


Phe Asp Tyr Cys Leu Lys Arg Ile Gln Ala Met Ser Leu Lys Ala Ser 
        275                 280                 285             


Ser Tyr Ile Asp Asp Leu Ala Ala Ala Gly His Asp Val Ser Lys Leu 
    290                 295                 300                 


Arg Ala Ile Leu His Tyr Phe Val Ser Thr Ser Asp Cys Glu Glu Arg 
305                 310                 315                 320 


Lys Tyr Phe Glu Asp Ala Gln 
                325         


<210>  4
<211>  984
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Coding sequence for variant GGS

<400>  4
atggattata acagcgcgga tttcaaggag atctggggca aggccgccga caccgcgctg       60

ctgggaccgt acaactacct cgccaacaac cggggccaca acatcagaga acacttgatc      120

gcagcgttcg gagcggttat caaggtggac aagagcgatc tcgaaaccat ttcgcacatc      180

accaagattt tgcataactc gtcgctgctt gttgatgacg tggaagacaa ctcgatgctc      240

cgacgaggcc tgccggcagc ccattgtctg tttgaagtcc cccaaaccat caactccgcc      300

aactacatgt actttgtggc tctgcaggag gtgctcaagc tcaagtctta tgatgccgtc      360

tccattttca ccgaggaaat gatcaacttg catagaggtc agggtatgga tctctactgg      420

agagaaacac tcacttgccc ctcggaagac gagtatctgg agatggtggt gcacaagacc      480

ggaggactgt ttcggctggc tctgagactt atgctgtcgg tggcatcgaa acaggaggac      540

catgaaaaga tcaactttga tctcacacac cttaccgaca cactgggagt catttaccag      600

attctggatg attacctcaa cctgcagtcc acggaattga ccgagaacaa gggattctgc      660

gaagatatca gcgaaggaaa gttttcgttt ccgctgattc acagcatccg gaccaacccg      720

gataaccacg agattctcaa cattctcaaa cagcgaacaa gcgacgcttc actcaaaaag      780

tacgccgtgg actacatgag aacagaaacc aagagtttcg actactgcct caagagaatc      840

caggccatgt cactcaaggc aagttcgtac attgatgatc tcgcagcagc cggccacgat      900

gtctccaagt tgcgagccat tttgcattat tttgtgtcca cctctgactg tgaggagaga      960

aagtactttg aggatgcgca gtaa                                             984


<210>  5
<211>  327
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Variant GGS

<400>  5

Met Asp Tyr Asn Ser Ala Asp Phe Lys Glu Ile Trp Gly Lys Ala Ala 
1               5                   10                  15      


Asp Thr Ala Leu Leu Gly Pro Tyr Asn Tyr Leu Ala Asn Asn Arg Gly 
            20                  25                  30          


His Asn Ile Arg Glu His Leu Ile Ala Ala Phe Gly Ala Val Ile Lys 
        35                  40                  45              


Val Asp Lys Ser Asp Leu Glu Thr Ile Ser His Ile Thr Lys Ile Leu 
    50                  55                  60                  


His Asn Ser Ser Leu Leu Val Asp Asp Val Glu Asp Asn Ser Met Leu 
65                  70                  75                  80  


Arg Arg Gly Leu Pro Ala Ala His Cys Leu Phe Gly Val Pro Gln Thr 
                85                  90                  95      


Ile Asn Ser Val Asn Tyr Met Tyr Phe Val Ala Leu Gln Glu Val Leu 
            100                 105                 110         


Lys Leu Lys Ser Tyr Asp Ala Val Ser Ile Phe Thr Glu Glu Met Ile 
        115                 120                 125             


Asn Leu His Arg Gly Gln Gly Met Asp Leu Tyr Trp Arg Glu Thr Leu 
    130                 135                 140                 


Thr Cys Pro Ser Glu Asp Glu Tyr Leu Glu Met Val Val His Lys Thr 
145                 150                 155                 160 


Gly Gly Leu Phe Arg Leu Ala Leu Arg Leu Met Leu Ser Val Ala Ser 
                165                 170                 175     


Lys Gln Glu Asp His Glu Lys Ile Asn Phe Asp Leu Thr His Leu Thr 
            180                 185                 190         


Asp Thr Leu Gly Val Ile Tyr Gln Ile Leu Asp Asp Tyr Leu Asn Leu 
        195                 200                 205             


Gln Ser Thr Glu Leu Thr Glu Asn Lys Gly Phe Cys Glu Asp Ile Ser 
    210                 215                 220                 


Glu Gly Lys Phe Ser Phe Pro Leu Ile His Ser Ile Arg Thr Asn Pro 
225                 230                 235                 240 


Asp Asn His Glu Ile Leu Asn Ile Leu Lys Gln Arg Thr Ser Asp Ala 
                245                 250                 255     


Ser Leu Lys Lys Tyr Ala Val Asp Tyr Met Arg Thr Glu Thr Lys Ser 
            260                 265                 270         


Phe Asp Tyr Cys Leu Lys Arg Ile Gln Ala Met Ser Leu Lys Ala Ser 
        275                 280                 285             


Ser Tyr Ile Asp Asp Leu Ala Ala Ala Gly His Asp Val Ser Lys Leu 
    290                 295                 300                 


Arg Ala Ile Leu His Tyr Phe Val Ser Thr Ser Asp Cys Glu Glu Arg 
305                 310                 315                 320 


Lys Tyr Phe Glu Asp Ala Gln 
                325         


<210>  6
<211>  984
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Coding sequence for variant GGS

<400>  6
atggattata acagcgcgga tttcaaggag atctggggca aggccgccga caccgcgctg       60

ctgggaccgt acaactacct cgccaacaac cggggccaca acatcagaga acacttgatc      120

gcagcgttcg gagcggttat caaggtggac aagagcgatc tcgaaaccat ttcgcacatc      180

accaagattt tgcataactc gtcgctgctt gttgatgacg tggaagacaa ctcgatgctc      240

cgacgaggcc tgccggcagc ccattgtctg tttggagtcc cccaaaccat caactccgtc      300

aactacatgt actttgtggc tctgcaggag gtgctcaagc tcaagtctta tgatgccgtc      360

tccattttca ccgaggaaat gatcaacttg catagaggtc agggtatgga tctctactgg      420

agagaaacac tcacttgccc ctcggaagac gagtatctgg agatggtggt gcacaagacc      480

ggaggactgt ttcggctggc tctgagactt atgctgtcgg tggcatcgaa acaggaggac      540

catgaaaaga tcaactttga tctcacacac cttaccgaca cactgggagt catttaccag      600

attctggatg attacctcaa cctgcagtcc acggaattga ccgagaacaa gggattctgc      660

gaagatatca gcgaaggaaa gttttcgttt ccgctgattc acagcatccg gaccaacccg      720

gataaccacg agattctcaa cattctcaaa cagcgaacaa gcgacgcttc actcaaaaag      780

tacgccgtgg actacatgag aacagaaacc aagagtttcg actactgcct caagagaatc      840

caggccatgt cactcaaggc aagttcgtac attgatgatc tcgcagcagc cggccacgat      900

gtctccaagt tgcgagccat tttgcattat tttgtgtcca cctctgactg tgaggagaga      960

aagtactttg aggatgcgca gtaa                                             984


<210>  7
<211>  327
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Variant GGS

<400>  7

Met Asp Tyr Asn Ser Ala Asp Phe Lys Glu Ile Trp Gly Lys Ala Ala 
1               5                   10                  15      


Asp Thr Ala Leu Leu Gly Pro Tyr Asn Tyr Leu Ala Asn Asn Arg Gly 
            20                  25                  30          


His Asn Ile Arg Glu His Leu Ile Ala Ala Phe Gly Ala Val Ile Lys 
        35                  40                  45              


Val Asp Lys Ser Asp Leu Glu Thr Ile Ser His Ile Thr Lys Ile Leu 
    50                  55                  60                  


His Asn Ser Ser Leu Leu Val Asp Asp Val Glu Asp Asn Ser Met Leu 
65                  70                  75                  80  


Arg Arg Gly Leu Pro Ala Ala His Cys Leu Phe Gly Val Pro Gln Thr 
                85                  90                  95      


Ile Asn Ser Ala Asn Tyr Met Tyr Phe Val Ala Leu Gln Glu Val Leu 
            100                 105                 110         


Lys Leu Lys Ser Tyr Asp Ala Val Ser Ile Phe Thr Glu Glu Met Ile 
        115                 120                 125             


Asn Leu His Arg Gly Gln Gly Met Asp Leu Tyr Trp Arg Glu Thr Leu 
    130                 135                 140                 


Thr Cys Pro Ser Glu Asp Glu Tyr Leu Glu Met Val Val His Lys Thr 
145                 150                 155                 160 


Gly Gly Leu Phe Arg Leu Ala Leu Arg Leu Met Leu Ser Val Ala Ser 
                165                 170                 175     


Lys Gln Glu Asp His Glu Lys Ile Asn Phe Asp Leu Thr His Leu Thr 
            180                 185                 190         


Asp Thr Leu Gly Val Ile Tyr Gln Ile Leu Asp Asp Tyr Leu Asn Leu 
        195                 200                 205             


Gln Ser Thr Glu Leu Thr Glu Asn Lys Gly Phe Cys Glu Asp Ile Ser 
    210                 215                 220                 


Glu Gly Lys Phe Ser Phe Pro Leu Ile His Asn Ile Arg Thr Asn Pro 
225                 230                 235                 240 


Asp Asn His Glu Ile Leu Asn Ile Leu Lys Gln Arg Thr Ser Asp Ala 
                245                 250                 255     


Ser Leu Lys Lys Tyr Ala Val Asp Tyr Met Arg Thr Glu Thr Lys Ser 
            260                 265                 270         


Phe Asp Tyr Cys Leu Lys Arg Ile Gln Ala Met Ser Leu Lys Ala Ser 
        275                 280                 285             


Ser Tyr Ile Asp Asp Leu Ala Ala Ala Gly His Asp Val Ser Lys Leu 
    290                 295                 300                 


Arg Ala Ile Leu His Tyr Phe Val Ser Thr Ser Asp Cys Glu Glu Arg 
305                 310                 315                 320 


Lys Tyr Phe Glu Asp Ala Gln 
                325         


<210>  8
<211>  984
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Coding sequence for GGS

<400>  8
atggattata acagcgcgga tttcaaggag atctggggca aggccgccga caccgcgctg       60

ctgggaccgt acaactacct cgccaacaac cggggccaca acatcagaga acacttgatc      120

gcagcgttcg gagcggttat caaggtggac aagagcgatc tcgaaaccat ttcgcacatc      180

accaagattt tgcataactc gtcgctgctt gttgatgacg tggaagacaa ctcgatgctc      240

cgacgaggcc tgccggcagc ccattgtctg tttggagtcc cccaaaccat caactccgcc      300

aactacatgt actttgtggc tctgcaggag gtgctcaagc tcaagtctta tgatgccgtc      360

tccattttca ccgaggaaat gatcaacttg catagaggtc agggtatgga tctctactgg      420

agagaaacac tcacttgccc ctcggaagac gagtatctgg agatggtggt gcacaagacc      480

ggaggactgt ttcggctggc tctgagactt atgctgtcgg tggcatcgaa acaggaggac      540

catgaaaaga tcaactttga tctcacacac cttaccgaca cactgggagt catttaccag      600

attctggatg attacctcaa cctgcagtcc acggaattga ccgagaacaa gggattctgc      660

gaagatatca gcgaaggaaa gttttcgttt ccgctgattc acaacatccg gaccaacccg      720

gataaccacg agattctcaa cattctcaaa cagcgaacaa gcgacgcttc actcaaaaag      780

tacgccgtgg actacatgag aacagaaacc aagagtttcg actactgcct caagagaatc      840

caggccatgt cactcaaggc aagttcgtac attgatgatc tcgcagcagc cggccacgat      900

gtctccaagt tgcgagccat tttgcattat tttgtgtcca cctctgactg tgaggagaga      960

aagtactttg aggatgcgca gtaa                                             984


<210>  9
<211>  327
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Variant GGS

<400>  9

Met Asp Tyr Asn Ser Ala Asp Phe Lys Glu Ile Trp Gly Lys Ala Ala 
1               5                   10                  15      


Asp Thr Ala Leu Leu Gly Pro Tyr Asn Tyr Leu Ala Asn Asn Arg Gly 
            20                  25                  30          


His Asn Ile Arg Glu His Leu Ile Ala Ala Phe Gly Ala Val Ile Lys 
        35                  40                  45              


Val Asp Lys Ser Asp Leu Glu Thr Ile Ser His Ile Thr Lys Ile Leu 
    50                  55                  60                  


His Asn Ser Ser Leu Leu Val Asp Asp Val Glu Asp Asn Ser Met Leu 
65                  70                  75                  80  


Arg Arg Gly Leu Pro Ala Ala His Cys Leu Phe Glu Val Pro Gln Thr 
                85                  90                  95      


Ile Asn Ser Val Asn Tyr Met Tyr Phe Val Ala Leu Gln Glu Val Leu 
            100                 105                 110         


Lys Leu Lys Ser Tyr Asp Ala Val Ser Ile Phe Thr Glu Glu Met Ile 
        115                 120                 125             


Asn Leu His Arg Gly Gln Gly Met Asp Leu Tyr Trp Arg Glu Thr Leu 
    130                 135                 140                 


Thr Cys Pro Ser Glu Asp Glu Tyr Leu Glu Met Val Val His Lys Thr 
145                 150                 155                 160 


Gly Gly Leu Phe Arg Leu Ala Leu Arg Leu Met Leu Ser Val Ala Ser 
                165                 170                 175     


Lys Gln Glu Asp His Glu Lys Ile Asn Phe Asp Leu Thr His Leu Thr 
            180                 185                 190         


Asp Thr Leu Gly Val Ile Tyr Gln Ile Leu Asp Asp Tyr Leu Asn Leu 
        195                 200                 205             


Gln Ser Thr Glu Leu Thr Glu Asn Lys Gly Phe Cys Glu Asp Ile Ser 
    210                 215                 220                 


Glu Gly Lys Phe Ser Phe Pro Leu Ile His Ser Ile Arg Thr Asn Pro 
225                 230                 235                 240 


Asp Asn His Glu Ile Leu Asn Ile Leu Lys Gln Arg Thr Ser Asp Ala 
                245                 250                 255     


Ser Leu Lys Lys Tyr Ala Val Asp Tyr Met Arg Thr Glu Thr Lys Ser 
            260                 265                 270         


Phe Asp Tyr Cys Leu Lys Arg Ile Gln Ala Met Ser Leu Lys Ala Ser 
        275                 280                 285             


Ser Tyr Ile Asp Asp Leu Ala Ala Ala Gly His Asp Val Ser Lys Leu 
    290                 295                 300                 


Arg Ala Ile Leu His Tyr Phe Val Ser Thr Ser Asp Cys Glu Glu Arg 
305                 310                 315                 320 


Lys Tyr Phe Glu Asp Ala Gln 
                325         


<210>  10
<211>  984
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Coding sequence for variant GGS

<400>  10
atggattata acagcgcgga tttcaaggag atctggggca aggccgccga caccgcgctg       60

ctgggaccgt acaactacct cgccaacaac cggggccaca acatcagaga acacttgatc      120

gcagcgttcg gagcggttat caaggtggac aagagcgatc tcgaaaccat ttcgcacatc      180

accaagattt tgcataactc gtcgctgctt gttgatgacg tggaagacaa ctcgatgctc      240

cgacgaggcc tgccggcagc ccattgtctg tttgaagtcc cccaaaccat caactccgtc      300

aactacatgt actttgtggc tctgcaggag gtgctcaagc tcaagtctta tgatgccgtc      360

tccattttca ccgaggaaat gatcaacttg catagaggtc agggtatgga tctctactgg      420

agagaaacac tcacttgccc ctcggaagac gagtatctgg agatggtggt gcacaagacc      480

ggaggactgt ttcggctggc tctgagactt atgctgtcgg tggcatcgaa acaggaggac      540

catgaaaaga tcaactttga tctcacacac cttaccgaca cactgggagt catttaccag      600

attctggatg attacctcaa cctgcagtcc acggaattga ccgagaacaa gggattctgc      660

gaagatatca gcgaaggaaa gttttcgttt ccgctgattc acagcatccg gaccaacccg      720

gataaccacg agattctcaa cattctcaaa cagcgaacaa gcgacgcttc actcaaaaag      780

tacgccgtgg actacatgag aacagaaacc aagagtttcg actactgcct caagagaatc      840

caggccatgt cactcaaggc aagttcgtac attgatgatc tcgcagcagc cggccacgat      900

gtctccaagt tgcgagccat tttgcattat tttgtgtcca cctctgactg tgaggagaga      960

aagtactttg aggatgcgca gtaa                                             984


<210>  11
<211>  327
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Variant GGS

<400>  11

Met Asp Tyr Asn Ser Ala Asp Phe Lys Glu Ile Trp Gly Lys Ala Ala 
1               5                   10                  15      


Asp Thr Ala Leu Leu Gly Pro Tyr Asn Tyr Leu Ala Asn Asn Arg Gly 
            20                  25                  30          


His Asn Ile Arg Glu His Leu Ile Ala Ala Phe Gly Ala Val Ile Lys 
        35                  40                  45              


Val Asp Lys Ser Asp Leu Glu Thr Ile Ser His Ile Thr Lys Ile Leu 
    50                  55                  60                  


His Asn Ser Ser Leu Leu Val Asp Asp Val Glu Asp Asn Ser Met Leu 
65                  70                  75                  80  


Arg Arg Gly Leu Pro Ala Ala His Cys Leu Phe Glu Val Pro Gln Thr 
                85                  90                  95      


Ile Asn Ser Ala Asn Tyr Met Tyr Phe Val Ala Leu Gln Glu Val Leu 
            100                 105                 110         


Lys Leu Lys Ser Tyr Asp Ala Val Ser Ile Phe Thr Glu Glu Met Ile 
        115                 120                 125             


Asn Leu His Arg Gly Gln Gly Met Asp Leu Tyr Trp Arg Glu Thr Leu 
    130                 135                 140                 


Thr Cys Pro Ser Glu Asp Glu Tyr Leu Glu Met Val Val His Lys Thr 
145                 150                 155                 160 


Gly Gly Leu Phe Arg Leu Ala Leu Arg Leu Met Leu Ser Val Ala Ser 
                165                 170                 175     


Lys Gln Glu Asp His Glu Lys Ile Asn Phe Asp Leu Thr His Leu Thr 
            180                 185                 190         


Asp Thr Leu Gly Val Ile Tyr Gln Ile Leu Asp Asp Tyr Leu Asn Leu 
        195                 200                 205             


Gln Ser Thr Glu Leu Thr Glu Asn Lys Gly Phe Cys Glu Asp Ile Ser 
    210                 215                 220                 


Glu Gly Lys Phe Ser Phe Pro Leu Ile His Asn Ile Arg Thr Asn Pro 
225                 230                 235                 240 


Asp Asn His Glu Ile Leu Asn Ile Leu Lys Gln Arg Thr Ser Asp Ala 
                245                 250                 255     


Ser Leu Lys Lys Tyr Ala Val Asp Tyr Met Arg Thr Glu Thr Lys Ser 
            260                 265                 270         


Phe Asp Tyr Cys Leu Lys Arg Ile Gln Ala Met Ser Leu Lys Ala Ser 
        275                 280                 285             


Ser Tyr Ile Asp Asp Leu Ala Ala Ala Gly His Asp Val Ser Lys Leu 
    290                 295                 300                 


Arg Ala Ile Leu His Tyr Phe Val Ser Thr Ser Asp Cys Glu Glu Arg 
305                 310                 315                 320 


Lys Tyr Phe Glu Asp Ala Gln 
                325         


<210>  12
<211>  984
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Coding sequence for variant GGS

<400>  12
atggattata acagcgcgga tttcaaggag atctggggca aggccgccga caccgcgctg       60

ctgggaccgt acaactacct cgccaacaac cggggccaca acatcagaga acacttgatc      120

gcagcgttcg gagcggttat caaggtggac aagagcgatc tcgaaaccat ttcgcacatc      180

accaagattt tgcataactc gtcgctgctt gttgatgacg tggaagacaa ctcgatgctc      240

cgacgaggcc tgccggcagc ccattgtctg tttgaagtcc cccaaaccat caactccgcc      300

aactacatgt actttgtggc tctgcaggag gtgctcaagc tcaagtctta tgatgccgtc      360

tccattttca ccgaggaaat gatcaacttg catagaggtc agggtatgga tctctactgg      420

agagaaacac tcacttgccc ctcggaagac gagtatctgg agatggtggt gcacaagacc      480

ggaggactgt ttcggctggc tctgagactt atgctgtcgg tggcatcgaa acaggaggac      540

catgaaaaga tcaactttga tctcacacac cttaccgaca cactgggagt catttaccag      600

attctggatg attacctcaa cctgcagtcc acggaattga ccgagaacaa gggattctgc      660

gaagatatca gcgaaggaaa gttttcgttt ccgctgattc acaacatccg gaccaacccg      720

gataaccacg agattctcaa cattctcaaa cagcgaacaa gcgacgcttc actcaaaaag      780

tacgccgtgg actacatgag aacagaaacc aagagtttcg actactgcct caagagaatc      840

caggccatgt cactcaaggc aagttcgtac attgatgatc tcgcagcagc cggccacgat      900

gtctccaagt tgcgagccat tttgcattat tttgtgtcca cctctgactg tgaggagaga      960

aagtactttg aggatgcgca gtaa                                             984


<210>  13
<211>  327
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Variant GGS

<400>  13

Met Asp Tyr Asn Ser Ala Asp Phe Lys Glu Ile Trp Gly Lys Ala Ala 
1               5                   10                  15      


Asp Thr Ala Leu Leu Gly Pro Tyr Asn Tyr Leu Ala Asn Asn Arg Gly 
            20                  25                  30          


His Asn Ile Arg Glu His Leu Ile Ala Ala Phe Gly Ala Val Ile Lys 
        35                  40                  45              


Val Asp Lys Ser Asp Leu Glu Thr Ile Ser His Ile Thr Lys Ile Leu 
    50                  55                  60                  


His Asn Ser Ser Leu Leu Val Asp Asp Val Glu Asp Asn Ser Met Leu 
65                  70                  75                  80  


Arg Arg Gly Leu Pro Ala Ala His Cys Leu Phe Gly Val Pro Gln Thr 
                85                  90                  95      


Ile Asn Ser Val Asn Tyr Met Tyr Phe Val Ala Leu Gln Glu Val Leu 
            100                 105                 110         


Lys Leu Lys Ser Tyr Asp Ala Val Ser Ile Phe Thr Glu Glu Met Ile 
        115                 120                 125             


Asn Leu His Arg Gly Gln Gly Met Asp Leu Tyr Trp Arg Glu Thr Leu 
    130                 135                 140                 


Thr Cys Pro Ser Glu Asp Glu Tyr Leu Glu Met Val Val His Lys Thr 
145                 150                 155                 160 


Gly Gly Leu Phe Arg Leu Ala Leu Arg Leu Met Leu Ser Val Ala Ser 
                165                 170                 175     


Lys Gln Glu Asp His Glu Lys Ile Asn Phe Asp Leu Thr His Leu Thr 
            180                 185                 190         


Asp Thr Leu Gly Val Ile Tyr Gln Ile Leu Asp Asp Tyr Leu Asn Leu 
        195                 200                 205             


Gln Ser Thr Glu Leu Thr Glu Asn Lys Gly Phe Cys Glu Asp Ile Ser 
    210                 215                 220                 


Glu Gly Lys Phe Ser Phe Pro Leu Ile His Asn Ile Arg Thr Asn Pro 
225                 230                 235                 240 


Asp Asn His Glu Ile Leu Asn Ile Leu Lys Gln Arg Thr Ser Asp Ala 
                245                 250                 255     


Ser Leu Lys Lys Tyr Ala Val Asp Tyr Met Arg Thr Glu Thr Lys Ser 
            260                 265                 270         


Phe Asp Tyr Cys Leu Lys Arg Ile Gln Ala Met Ser Leu Lys Ala Ser 
        275                 280                 285             


Ser Tyr Ile Asp Asp Leu Ala Ala Ala Gly His Asp Val Ser Lys Leu 
    290                 295                 300                 


Arg Ala Ile Leu His Tyr Phe Val Ser Thr Ser Asp Cys Glu Glu Arg 
305                 310                 315                 320 


Lys Tyr Phe Glu Asp Ala Gln 
                325         


<210>  14
<211>  984
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Coding sequence for GGS

<400>  14
atggattata acagcgcgga tttcaaggag atctggggca aggccgccga caccgcgctg       60

ctgggaccgt acaactacct cgccaacaac cggggccaca acatcagaga acacttgatc      120

gcagcgttcg gagcggttat caaggtggac aagagcgatc tcgaaaccat ttcgcacatc      180

accaagattt tgcataactc gtcgctgctt gttgatgacg tggaagacaa ctcgatgctc      240

cgacgaggcc tgccggcagc ccattgtctg tttggagtcc cccaaaccat caactccgtc      300

aactacatgt actttgtggc tctgcaggag gtgctcaagc tcaagtctta tgatgccgtc      360

tccattttca ccgaggaaat gatcaacttg catagaggtc agggtatgga tctctactgg      420

agagaaacac tcacttgccc ctcggaagac gagtatctgg agatggtggt gcacaagacc      480

ggaggactgt ttcggctggc tctgagactt atgctgtcgg tggcatcgaa acaggaggac      540

catgaaaaga tcaactttga tctcacacac cttaccgaca cactgggagt catttaccag      600

attctggatg attacctcaa cctgcagtcc acggaattga ccgagaacaa gggattctgc      660

gaagatatca gcgaaggaaa gttttcgttt ccgctgattc acaacatccg gaccaacccg      720

gataaccacg agattctcaa cattctcaaa cagcgaacaa gcgacgcttc actcaaaaag      780

tacgccgtgg actacatgag aacagaaacc aagagtttcg actactgcct caagagaatc      840

caggccatgt cactcaaggc aagttcgtac attgatgatc tcgcagcagc cggccacgat      900

gtctccaagt tgcgagccat tttgcattat tttgtgtcca cctctgactg tgaggagaga      960

aagtactttg aggatgcgca gtaa                                             984


<210>  15
<211>  327
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Variant GGS

<400>  15

Met Asp Tyr Asn Ser Ala Asp Phe Lys Glu Ile Trp Gly Lys Ala Ala 
1               5                   10                  15      


Asp Thr Ala Leu Leu Gly Pro Tyr Asn Tyr Leu Ala Asn Asn Arg Gly 
            20                  25                  30          


His Asn Ile Arg Glu His Leu Ile Ala Ala Phe Gly Ala Val Ile Lys 
        35                  40                  45              


Val Asp Lys Ser Asp Leu Glu Thr Ile Ser His Ile Thr Lys Ile Leu 
    50                  55                  60                  


His Asn Ser Ser Leu Leu Val Asp Asp Val Glu Asp Asn Ser Met Leu 
65                  70                  75                  80  


Arg Arg Gly Leu Pro Ala Ala His Cys Leu Phe Glu Val Pro Gln Thr 
                85                  90                  95      


Ile Asn Ser Val Asn Tyr Met Tyr Phe Val Ala Leu Gln Glu Val Leu 
            100                 105                 110         


Lys Leu Lys Ser Tyr Asp Ala Val Ser Ile Phe Thr Glu Glu Met Ile 
        115                 120                 125             


Asn Leu His Arg Gly Gln Gly Met Asp Leu Tyr Trp Arg Glu Thr Leu 
    130                 135                 140                 


Thr Cys Pro Ser Glu Asp Glu Tyr Leu Glu Met Val Val His Lys Thr 
145                 150                 155                 160 


Gly Gly Leu Phe Arg Leu Ala Leu Arg Leu Met Leu Ser Val Ala Ser 
                165                 170                 175     


Lys Gln Glu Asp His Glu Lys Ile Asn Phe Asp Leu Thr His Leu Thr 
            180                 185                 190         


Asp Thr Leu Gly Val Ile Tyr Gln Ile Leu Asp Asp Tyr Leu Asn Leu 
        195                 200                 205             


Gln Ser Thr Glu Leu Thr Glu Asn Lys Gly Phe Cys Glu Asp Ile Ser 
    210                 215                 220                 


Glu Gly Lys Phe Ser Phe Pro Leu Ile His Asn Ile Arg Thr Asn Pro 
225                 230                 235                 240 


Asp Asn His Glu Ile Leu Asn Ile Leu Lys Gln Arg Thr Ser Asp Ala 
                245                 250                 255     


Ser Leu Lys Lys Tyr Ala Val Asp Tyr Met Arg Thr Glu Thr Lys Ser 
            260                 265                 270         


Phe Asp Tyr Cys Leu Lys Arg Ile Gln Ala Met Ser Leu Lys Ala Ser 
        275                 280                 285             


Ser Tyr Ile Asp Asp Leu Ala Ala Ala Gly His Asp Val Ser Lys Leu 
    290                 295                 300                 


Arg Ala Ile Leu His Tyr Phe Val Ser Thr Ser Asp Cys Glu Glu Arg 
305                 310                 315                 320 


Lys Tyr Phe Glu Asp Ala Gln 
                325         


<210>  16
<211>  984
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Coding sequence for variant GGS

<400>  16
atggattata acagcgcgga tttcaaggag atctggggca aggccgccga caccgcgctg       60

ctgggaccgt acaactacct cgccaacaac cggggccaca acatcagaga acacttgatc      120

gcagcgttcg gagcggttat caaggtggac aagagcgatc tcgaaaccat ttcgcacatc      180

accaagattt tgcataactc gtcgctgctt gttgatgacg tggaagacaa ctcgatgctc      240

cgacgaggcc tgccggcagc ccattgtctg tttgaagtcc cccaaaccat caactccgtc      300

aactacatgt actttgtggc tctgcaggag gtgctcaagc tcaagtctta tgatgccgtc      360

tccattttca ccgaggaaat gatcaacttg catagaggtc agggtatgga tctctactgg      420

agagaaacac tcacttgccc ctcggaagac gagtatctgg agatggtggt gcacaagacc      480

ggaggactgt ttcggctggc tctgagactt atgctgtcgg tggcatcgaa acaggaggac      540

catgaaaaga tcaactttga tctcacacac cttaccgaca cactgggagt catttaccag      600

attctggatg attacctcaa cctgcagtcc acggaattga ccgagaacaa gggattctgc      660

gaagatatca gcgaaggaaa gttttcgttt ccgctgattc acaacatccg gaccaacccg      720

gataaccacg agattctcaa cattctcaaa cagcgaacaa gcgacgcttc actcaaaaag      780

tacgccgtgg actacatgag aacagaaacc aagagtttcg actactgcct caagagaatc      840

caggccatgt cactcaaggc aagttcgtac attgatgatc tcgcagcagc cggccacgat      900

gtctccaagt tgcgagccat tttgcattat tttgtgtcca cctctgactg tgaggagaga      960

aagtactttg aggatgcgca gtaa                                             984


<210>  17
<211>  303
<212>  PRT
<213>  Mucor circinelloides

<400>  17

Met Leu Asn Ser His Asn Arg Thr Glu Glu Arg Ser Thr Glu Asp Ile 
1               5                   10                  15      


Ile Leu Glu Pro Tyr Thr Tyr Leu Ile Ser Gln Pro Gly Lys Asp Ile 
            20                  25                  30          


Arg Ala Lys Leu Ile Ser Ala Phe Asp Leu Trp Leu His Val Pro Lys 
        35                  40                  45              


Asp Val Leu Cys Val Ile Asn Lys Ile Ile Gly Met Leu His Asn Ala 
    50                  55                  60                  


Ser Leu Met Ile Asp Asp Val Gln Asp Asp Ser Asp Leu Arg Arg Gly 
65                  70                  75                  80  


Val Pro Val Ala His His Ile Tyr Gly Val Pro Gln Thr Ile Asn Thr 
                85                  90                  95      


Ala Asn Tyr Val Ile Phe Leu Ala Leu Gln Glu Val Met Lys Leu Asn 
            100                 105                 110         


Ile Pro Ser Met Met Gln Val Cys Thr Glu Glu Leu Ile Asn Leu His 
        115                 120                 125             


Arg Gly Gln Gly Ile Glu Leu Tyr Trp Arg Asp Ser Leu Thr Cys Pro 
    130                 135                 140                 


Thr Glu Glu Glu Tyr Ile Asp Met Val Asn Asn Lys Thr Ser Gly Leu 
145                 150                 155                 160 


Leu Arg Leu Ala Val Arg Leu Met Gln Ala Ala Ser Glu Ser Asp Ile 
                165                 170                 175     


Asp Tyr Thr Pro Leu Val Asn Ile Ile Gly Ile His Phe Gln Val Arg 
            180                 185                 190         


Asp Asp Tyr Met Asn Leu Gln Ser Thr Ser Tyr Thr Asn Asn Lys Gly 
        195                 200                 205             


Phe Cys Glu Asp Leu Thr Glu Gly Lys Phe Ser Phe Pro Ile Ile His 
    210                 215                 220                 


Ala Ile Arg Lys Asp Pro Ser Asn Arg Gln Leu Leu Asn Ile Ile Ser 
225                 230                 235                 240 


Gln Lys Pro Thr Ser Ile Glu Val Lys Lys Tyr Ala Leu Glu Val Ile 
                245                 250                 255     


Arg Lys Ala Gly Ser Phe Glu Tyr Val Arg Glu Phe Leu Arg Gln Lys 
            260                 265                 270         


Glu Ala Glu Ser Leu Lys Glu Ile Lys Arg Leu Gly Gly Asn Pro Leu 
        275                 280                 285             


Leu Glu Lys Tyr Ile Glu Thr Ile Arg Val Glu Ala Thr Asn Asp 
    290                 295                 300             


<210>  18
<211>  327
<212>  PRT
<213>  Artificial sequence

<220>
<223>  GGS variant

<400>  18

Met Asp Tyr Asn Ser Ala Asp Phe Lys Glu Ile Trp Gly Lys Ala Ala 
1               5                   10                  15      


Asp Thr Ala Leu Leu Gly Pro Tyr Asn Tyr Leu Ala Asn Asn Arg Gly 
            20                  25                  30          


His Asn Ile Arg Glu His Leu Ile Ala Ala Phe Gly Ala Val Ile Lys 
        35                  40                  45              


Val Asp Lys Ser Asp Leu Glu Thr Ile Ser His Ile Thr Lys Ile Leu 
    50                  55                  60                  


His Asn Ser Ser Leu Leu Val Asp Asp Val Glu Asp Asn Ser Met Leu 
65                  70                  75                  80  


Arg Arg Gly Leu Pro Ala Ala His Cys Leu Phe Asp Val Pro Gln Thr 
                85                  90                  95      


Ile Asn Ser Ala Asn Tyr Met Tyr Phe Val Ala Leu Gln Glu Val Leu 
            100                 105                 110         


Lys Leu Lys Ser Tyr Asp Ala Val Ser Ile Phe Thr Glu Glu Met Ile 
        115                 120                 125             


Asn Leu His Arg Gly Gln Gly Met Asp Leu Tyr Trp Arg Glu Thr Leu 
    130                 135                 140                 


Thr Cys Pro Ser Glu Asp Glu Tyr Leu Glu Met Val Val His Lys Thr 
145                 150                 155                 160 


Gly Gly Leu Phe Arg Leu Ala Leu Arg Leu Met Leu Ser Val Ala Ser 
                165                 170                 175     


Lys Gln Glu Asp His Glu Lys Ile Asn Phe Asp Leu Thr His Leu Thr 
            180                 185                 190         


Asp Thr Leu Gly Val Ile Tyr Gln Ile Leu Asp Asp Tyr Leu Asn Leu 
        195                 200                 205             


Gln Ser Thr Glu Leu Thr Glu Asn Lys Gly Phe Cys Glu Asp Ile Ser 
    210                 215                 220                 


Glu Gly Lys Phe Ser Phe Pro Leu Ile His Ser Ile Arg Thr Asn Pro 
225                 230                 235                 240 


Asp Asn His Glu Ile Leu Asn Ile Leu Lys Gln Arg Thr Ser Asp Ala 
                245                 250                 255     


Ser Leu Lys Lys Tyr Ala Val Asp Tyr Met Arg Thr Glu Thr Lys Ser 
            260                 265                 270         


Phe Asp Tyr Cys Leu Lys Arg Ile Gln Ala Met Ser Leu Lys Ala Ser 
        275                 280                 285             


Ser Tyr Ile Asp Asp Leu Ala Ala Ala Gly His Asp Val Ser Lys Leu 
    290                 295                 300                 


Arg Ala Ile Leu His Tyr Phe Val Ser Thr Ser Asp Cys Glu Glu Arg 
305                 310                 315                 320 


Lys Tyr Phe Glu Asp Ala Gln 
                325         


<210>  19
<211>  327
<212>  PRT
<213>  Artificial sequence

<220>
<223>  GGS variant

<400>  19

Met Asp Tyr Asn Ser Ala Asp Phe Lys Glu Ile Trp Gly Lys Ala Ala 
1               5                   10                  15      


Asp Thr Ala Leu Leu Gly Pro Tyr Asn Tyr Leu Ala Asn Asn Arg Gly 
            20                  25                  30          


His Asn Ile Arg Glu His Leu Ile Ala Ala Phe Gly Ala Val Ile Lys 
        35                  40                  45              


Val Asp Lys Ser Asp Leu Glu Thr Ile Ser His Ile Thr Lys Ile Leu 
    50                  55                  60                  


His Asn Ser Ser Leu Leu Val Asp Asp Val Glu Asp Asn Ser Met Leu 
65                  70                  75                  80  


Arg Arg Gly Leu Pro Ala Ala His Cys Leu Phe Asn Val Pro Gln Thr 
                85                  90                  95      


Ile Asn Ser Ala Asn Tyr Met Tyr Phe Val Ala Leu Gln Glu Val Leu 
            100                 105                 110         


Lys Leu Lys Ser Tyr Asp Ala Val Ser Ile Phe Thr Glu Glu Met Ile 
        115                 120                 125             


Asn Leu His Arg Gly Gln Gly Met Asp Leu Tyr Trp Arg Glu Thr Leu 
    130                 135                 140                 


Thr Cys Pro Ser Glu Asp Glu Tyr Leu Glu Met Val Val His Lys Thr 
145                 150                 155                 160 


Gly Gly Leu Phe Arg Leu Ala Leu Arg Leu Met Leu Ser Val Ala Ser 
                165                 170                 175     


Lys Gln Glu Asp His Glu Lys Ile Asn Phe Asp Leu Thr His Leu Thr 
            180                 185                 190         


Asp Thr Leu Gly Val Ile Tyr Gln Ile Leu Asp Asp Tyr Leu Asn Leu 
        195                 200                 205             


Gln Ser Thr Glu Leu Thr Glu Asn Lys Gly Phe Cys Glu Asp Ile Ser 
    210                 215                 220                 


Glu Gly Lys Phe Ser Phe Pro Leu Ile His Ser Ile Arg Thr Asn Pro 
225                 230                 235                 240 


Asp Asn His Glu Ile Leu Asn Ile Leu Lys Gln Arg Thr Ser Asp Ala 
                245                 250                 255     


Ser Leu Lys Lys Tyr Ala Val Asp Tyr Met Arg Thr Glu Thr Lys Ser 
            260                 265                 270         


Phe Asp Tyr Cys Leu Lys Arg Ile Gln Ala Met Ser Leu Lys Ala Ser 
        275                 280                 285             


Ser Tyr Ile Asp Asp Leu Ala Ala Ala Gly His Asp Val Ser Lys Leu 
    290                 295                 300                 


Arg Ala Ile Leu His Tyr Phe Val Ser Thr Ser Asp Cys Glu Glu Arg 
305                 310                 315                 320 


Lys Tyr Phe Glu Asp Ala Gln 
                325         


<210>  20
<211>  327
<212>  PRT
<213>  Artificial sequence

<220>
<223>  GGS variant

<400>  20

Met Asp Tyr Asn Ser Ala Asp Phe Lys Glu Ile Trp Gly Lys Ala Ala 
1               5                   10                  15      


Asp Thr Ala Leu Leu Gly Pro Tyr Asn Tyr Leu Ala Asn Asn Arg Gly 
            20                  25                  30          


His Asn Ile Arg Glu His Leu Ile Ala Ala Phe Gly Ala Val Ile Lys 
        35                  40                  45              


Val Asp Lys Ser Asp Leu Glu Thr Ile Ser His Ile Thr Lys Ile Leu 
    50                  55                  60                  


His Asn Ser Ser Leu Leu Val Asp Asp Val Glu Asp Asn Ser Met Leu 
65                  70                  75                  80  


Arg Arg Gly Leu Pro Ala Ala His Cys Leu Phe Gln Val Pro Gln Thr 
                85                  90                  95      


Ile Asn Ser Ala Asn Tyr Met Tyr Phe Val Ala Leu Gln Glu Val Leu 
            100                 105                 110         


Lys Leu Lys Ser Tyr Asp Ala Val Ser Ile Phe Thr Glu Glu Met Ile 
        115                 120                 125             


Asn Leu His Arg Gly Gln Gly Met Asp Leu Tyr Trp Arg Glu Thr Leu 
    130                 135                 140                 


Thr Cys Pro Ser Glu Asp Glu Tyr Leu Glu Met Val Val His Lys Thr 
145                 150                 155                 160 


Gly Gly Leu Phe Arg Leu Ala Leu Arg Leu Met Leu Ser Val Ala Ser 
                165                 170                 175     


Lys Gln Glu Asp His Glu Lys Ile Asn Phe Asp Leu Thr His Leu Thr 
            180                 185                 190         


Asp Thr Leu Gly Val Ile Tyr Gln Ile Leu Asp Asp Tyr Leu Asn Leu 
        195                 200                 205             


Gln Ser Thr Glu Leu Thr Glu Asn Lys Gly Phe Cys Glu Asp Ile Ser 
    210                 215                 220                 


Glu Gly Lys Phe Ser Phe Pro Leu Ile His Ser Ile Arg Thr Asn Pro 
225                 230                 235                 240 


Asp Asn His Glu Ile Leu Asn Ile Leu Lys Gln Arg Thr Ser Asp Ala 
                245                 250                 255     


Ser Leu Lys Lys Tyr Ala Val Asp Tyr Met Arg Thr Glu Thr Lys Ser 
            260                 265                 270         


Phe Asp Tyr Cys Leu Lys Arg Ile Gln Ala Met Ser Leu Lys Ala Ser 
        275                 280                 285             


Ser Tyr Ile Asp Asp Leu Ala Ala Ala Gly His Asp Val Ser Lys Leu 
    290                 295                 300                 


Arg Ala Ile Leu His Tyr Phe Val Ser Thr Ser Asp Cys Glu Glu Arg 
305                 310                 315                 320 


Lys Tyr Phe Glu Asp Ala Gln 
                325         


<210>  21
<211>  327
<212>  PRT
<213>  Artificial sequence

<220>
<223>  GGS variant

<400>  21

Met Asp Tyr Asn Ser Ala Asp Phe Lys Glu Ile Trp Gly Lys Ala Ala 
1               5                   10                  15      


Asp Thr Ala Leu Leu Gly Pro Tyr Asn Tyr Leu Ala Asn Asn Arg Gly 
            20                  25                  30          


His Asn Ile Arg Glu His Leu Ile Ala Ala Phe Gly Ala Val Ile Lys 
        35                  40                  45              


Val Asp Lys Ser Asp Leu Glu Thr Ile Ser His Ile Thr Lys Ile Leu 
    50                  55                  60                  


His Asn Ser Ser Leu Leu Val Asp Asp Val Glu Asp Asn Ser Met Leu 
65                  70                  75                  80  


Arg Arg Gly Leu Pro Ala Ala His Cys Leu Phe Gly Val Pro Gln Thr 
                85                  90                  95      


Ile Asn Ser Gly Asn Tyr Met Tyr Phe Val Ala Leu Gln Glu Val Leu 
            100                 105                 110         


Lys Leu Lys Ser Tyr Asp Ala Val Ser Ile Phe Thr Glu Glu Met Ile 
        115                 120                 125             


Asn Leu His Arg Gly Gln Gly Met Asp Leu Tyr Trp Arg Glu Thr Leu 
    130                 135                 140                 


Thr Cys Pro Ser Glu Asp Glu Tyr Leu Glu Met Val Val His Lys Thr 
145                 150                 155                 160 


Gly Gly Leu Phe Arg Leu Ala Leu Arg Leu Met Leu Ser Val Ala Ser 
                165                 170                 175     


Lys Gln Glu Asp His Glu Lys Ile Asn Phe Asp Leu Thr His Leu Thr 
            180                 185                 190         


Asp Thr Leu Gly Val Ile Tyr Gln Ile Leu Asp Asp Tyr Leu Asn Leu 
        195                 200                 205             


Gln Ser Thr Glu Leu Thr Glu Asn Lys Gly Phe Cys Glu Asp Ile Ser 
    210                 215                 220                 


Glu Gly Lys Phe Ser Phe Pro Leu Ile His Ser Ile Arg Thr Asn Pro 
225                 230                 235                 240 


Asp Asn His Glu Ile Leu Asn Ile Leu Lys Gln Arg Thr Ser Asp Ala 
                245                 250                 255     


Ser Leu Lys Lys Tyr Ala Val Asp Tyr Met Arg Thr Glu Thr Lys Ser 
            260                 265                 270         


Phe Asp Tyr Cys Leu Lys Arg Ile Gln Ala Met Ser Leu Lys Ala Ser 
        275                 280                 285             


Ser Tyr Ile Asp Asp Leu Ala Ala Ala Gly His Asp Val Ser Lys Leu 
    290                 295                 300                 


Arg Ala Ile Leu His Tyr Phe Val Ser Thr Ser Asp Cys Glu Glu Arg 
305                 310                 315                 320 


Lys Tyr Phe Glu Asp Ala Gln 
                325         


<210>  22
<211>  327
<212>  PRT
<213>  Artificial sequence

<220>
<223>  GGS variant

<400>  22

Met Asp Tyr Asn Ser Ala Asp Phe Lys Glu Ile Trp Gly Lys Ala Ala 
1               5                   10                  15      


Asp Thr Ala Leu Leu Gly Pro Tyr Asn Tyr Leu Ala Asn Asn Arg Gly 
            20                  25                  30          


His Asn Ile Arg Glu His Leu Ile Ala Ala Phe Gly Ala Val Ile Lys 
        35                  40                  45              


Val Asp Lys Ser Asp Leu Glu Thr Ile Ser His Ile Thr Lys Ile Leu 
    50                  55                  60                  


His Asn Ser Ser Leu Leu Val Asp Asp Val Glu Asp Asn Ser Met Leu 
65                  70                  75                  80  


Arg Arg Gly Leu Pro Ala Ala His Cys Leu Phe Gly Val Pro Gln Thr 
                85                  90                  95      


Ile Asn Ser Phe Asn Tyr Met Tyr Phe Val Ala Leu Gln Glu Val Leu 
            100                 105                 110         


Lys Leu Lys Ser Tyr Asp Ala Val Ser Ile Phe Thr Glu Glu Met Ile 
        115                 120                 125             


Asn Leu His Arg Gly Gln Gly Met Asp Leu Tyr Trp Arg Glu Thr Leu 
    130                 135                 140                 


Thr Cys Pro Ser Glu Asp Glu Tyr Leu Glu Met Val Val His Lys Thr 
145                 150                 155                 160 


Gly Gly Leu Phe Arg Leu Ala Leu Arg Leu Met Leu Ser Val Ala Ser 
                165                 170                 175     


Lys Gln Glu Asp His Glu Lys Ile Asn Phe Asp Leu Thr His Leu Thr 
            180                 185                 190         


Asp Thr Leu Gly Val Ile Tyr Gln Ile Leu Asp Asp Tyr Leu Asn Leu 
        195                 200                 205             


Gln Ser Thr Glu Leu Thr Glu Asn Lys Gly Phe Cys Glu Asp Ile Ser 
    210                 215                 220                 


Glu Gly Lys Phe Ser Phe Pro Leu Ile His Ser Ile Arg Thr Asn Pro 
225                 230                 235                 240 


Asp Asn His Glu Ile Leu Asn Ile Leu Lys Gln Arg Thr Ser Asp Ala 
                245                 250                 255     


Ser Leu Lys Lys Tyr Ala Val Asp Tyr Met Arg Thr Glu Thr Lys Ser 
            260                 265                 270         


Phe Asp Tyr Cys Leu Lys Arg Ile Gln Ala Met Ser Leu Lys Ala Ser 
        275                 280                 285             


Ser Tyr Ile Asp Asp Leu Ala Ala Ala Gly His Asp Val Ser Lys Leu 
    290                 295                 300                 


Arg Ala Ile Leu His Tyr Phe Val Ser Thr Ser Asp Cys Glu Glu Arg 
305                 310                 315                 320 


Lys Tyr Phe Glu Asp Ala Gln 
                325         


<210>  23
<211>  327
<212>  PRT
<213>  Artificial sequence

<220>
<223>  GGS variant

<400>  23

Met Asp Tyr Asn Ser Ala Asp Phe Lys Glu Ile Trp Gly Lys Ala Ala 
1               5                   10                  15      


Asp Thr Ala Leu Leu Gly Pro Tyr Asn Tyr Leu Ala Asn Asn Arg Gly 
            20                  25                  30          


His Asn Ile Arg Glu His Leu Ile Ala Ala Phe Gly Ala Val Ile Lys 
        35                  40                  45              


Val Asp Lys Ser Asp Leu Glu Thr Ile Ser His Ile Thr Lys Ile Leu 
    50                  55                  60                  


His Asn Ser Ser Leu Leu Val Asp Asp Val Glu Asp Asn Ser Met Leu 
65                  70                  75                  80  


Arg Arg Gly Leu Pro Ala Ala His Cys Leu Phe Gly Val Pro Gln Thr 
                85                  90                  95      


Ile Asn Ser Tyr Asn Tyr Met Tyr Phe Val Ala Leu Gln Glu Val Leu 
            100                 105                 110         


Lys Leu Lys Ser Tyr Asp Ala Val Ser Ile Phe Thr Glu Glu Met Ile 
        115                 120                 125             


Asn Leu His Arg Gly Gln Gly Met Asp Leu Tyr Trp Arg Glu Thr Leu 
    130                 135                 140                 


Thr Cys Pro Ser Glu Asp Glu Tyr Leu Glu Met Val Val His Lys Thr 
145                 150                 155                 160 


Gly Gly Leu Phe Arg Leu Ala Leu Arg Leu Met Leu Ser Val Ala Ser 
                165                 170                 175     


Lys Gln Glu Asp His Glu Lys Ile Asn Phe Asp Leu Thr His Leu Thr 
            180                 185                 190         


Asp Thr Leu Gly Val Ile Tyr Gln Ile Leu Asp Asp Tyr Leu Asn Leu 
        195                 200                 205             


Gln Ser Thr Glu Leu Thr Glu Asn Lys Gly Phe Cys Glu Asp Ile Ser 
    210                 215                 220                 


Glu Gly Lys Phe Ser Phe Pro Leu Ile His Ser Ile Arg Thr Asn Pro 
225                 230                 235                 240 


Asp Asn His Glu Ile Leu Asn Ile Leu Lys Gln Arg Thr Ser Asp Ala 
                245                 250                 255     


Ser Leu Lys Lys Tyr Ala Val Asp Tyr Met Arg Thr Glu Thr Lys Ser 
            260                 265                 270         


Phe Asp Tyr Cys Leu Lys Arg Ile Gln Ala Met Ser Leu Lys Ala Ser 
        275                 280                 285             


Ser Tyr Ile Asp Asp Leu Ala Ala Ala Gly His Asp Val Ser Lys Leu 
    290                 295                 300                 


Arg Ala Ile Leu His Tyr Phe Val Ser Thr Ser Asp Cys Glu Glu Arg 
305                 310                 315                 320 


Lys Tyr Phe Glu Asp Ala Gln 
                325         


<210>  24
<211>  327
<212>  PRT
<213>  Artificial sequence

<220>
<223>  GGS variant

<400>  24

Met Asp Tyr Asn Ser Ala Asp Phe Lys Glu Ile Trp Gly Lys Ala Ala 
1               5                   10                  15      


Asp Thr Ala Leu Leu Gly Pro Tyr Asn Tyr Leu Ala Asn Asn Arg Gly 
            20                  25                  30          


His Asn Ile Arg Glu His Leu Ile Ala Ala Phe Gly Ala Val Ile Lys 
        35                  40                  45              


Val Asp Lys Ser Asp Leu Glu Thr Ile Ser His Ile Thr Lys Ile Leu 
    50                  55                  60                  


His Asn Ser Ser Leu Leu Val Asp Asp Val Glu Asp Asn Ser Met Leu 
65                  70                  75                  80  


Arg Arg Gly Leu Pro Ala Ala His Cys Leu Phe Gly Val Pro Gln Thr 
                85                  90                  95      


Ile Asn Ser Ile Asn Tyr Met Tyr Phe Val Ala Leu Gln Glu Val Leu 
            100                 105                 110         


Lys Leu Lys Ser Tyr Asp Ala Val Ser Ile Phe Thr Glu Glu Met Ile 
        115                 120                 125             


Asn Leu His Arg Gly Gln Gly Met Asp Leu Tyr Trp Arg Glu Thr Leu 
    130                 135                 140                 


Thr Cys Pro Ser Glu Asp Glu Tyr Leu Glu Met Val Val His Lys Thr 
145                 150                 155                 160 


Gly Gly Leu Phe Arg Leu Ala Leu Arg Leu Met Leu Ser Val Ala Ser 
                165                 170                 175     


Lys Gln Glu Asp His Glu Lys Ile Asn Phe Asp Leu Thr His Leu Thr 
            180                 185                 190         


Asp Thr Leu Gly Val Ile Tyr Gln Ile Leu Asp Asp Tyr Leu Asn Leu 
        195                 200                 205             


Gln Ser Thr Glu Leu Thr Glu Asn Lys Gly Phe Cys Glu Asp Ile Ser 
    210                 215                 220                 


Glu Gly Lys Phe Ser Phe Pro Leu Ile His Ser Ile Arg Thr Asn Pro 
225                 230                 235                 240 


Asp Asn His Glu Ile Leu Asn Ile Leu Lys Gln Arg Thr Ser Asp Ala 
                245                 250                 255     


Ser Leu Lys Lys Tyr Ala Val Asp Tyr Met Arg Thr Glu Thr Lys Ser 
            260                 265                 270         


Phe Asp Tyr Cys Leu Lys Arg Ile Gln Ala Met Ser Leu Lys Ala Ser 
        275                 280                 285             


Ser Tyr Ile Asp Asp Leu Ala Ala Ala Gly His Asp Val Ser Lys Leu 
    290                 295                 300                 


Arg Ala Ile Leu His Tyr Phe Val Ser Thr Ser Asp Cys Glu Glu Arg 
305                 310                 315                 320 


Lys Tyr Phe Glu Asp Ala Gln 
                325         


<210>  25
<211>  327
<212>  PRT
<213>  Artificial sequence

<220>
<223>  GGS variant

<400>  25

Met Asp Tyr Asn Ser Ala Asp Phe Lys Glu Ile Trp Gly Lys Ala Ala 
1               5                   10                  15      


Asp Thr Ala Leu Leu Gly Pro Tyr Asn Tyr Leu Ala Asn Asn Arg Gly 
            20                  25                  30          


His Asn Ile Arg Glu His Leu Ile Ala Ala Phe Gly Ala Val Ile Lys 
        35                  40                  45              


Val Asp Lys Ser Asp Leu Glu Thr Ile Ser His Ile Thr Lys Ile Leu 
    50                  55                  60                  


His Asn Ser Ser Leu Leu Val Asp Asp Val Glu Asp Asn Ser Met Leu 
65                  70                  75                  80  


Arg Arg Gly Leu Pro Ala Ala His Cys Leu Phe Gly Val Pro Gln Thr 
                85                  90                  95      


Ile Asn Ser Leu Asn Tyr Met Tyr Phe Val Ala Leu Gln Glu Val Leu 
            100                 105                 110         


Lys Leu Lys Ser Tyr Asp Ala Val Ser Ile Phe Thr Glu Glu Met Ile 
        115                 120                 125             


Asn Leu His Arg Gly Gln Gly Met Asp Leu Tyr Trp Arg Glu Thr Leu 
    130                 135                 140                 


Thr Cys Pro Ser Glu Asp Glu Tyr Leu Glu Met Val Val His Lys Thr 
145                 150                 155                 160 


Gly Gly Leu Phe Arg Leu Ala Leu Arg Leu Met Leu Ser Val Ala Ser 
                165                 170                 175     


Lys Gln Glu Asp His Glu Lys Ile Asn Phe Asp Leu Thr His Leu Thr 
            180                 185                 190         


Asp Thr Leu Gly Val Ile Tyr Gln Ile Leu Asp Asp Tyr Leu Asn Leu 
        195                 200                 205             


Gln Ser Thr Glu Leu Thr Glu Asn Lys Gly Phe Cys Glu Asp Ile Ser 
    210                 215                 220                 


Glu Gly Lys Phe Ser Phe Pro Leu Ile His Ser Ile Arg Thr Asn Pro 
225                 230                 235                 240 


Asp Asn His Glu Ile Leu Asn Ile Leu Lys Gln Arg Thr Ser Asp Ala 
                245                 250                 255     


Ser Leu Lys Lys Tyr Ala Val Asp Tyr Met Arg Thr Glu Thr Lys Ser 
            260                 265                 270         


Phe Asp Tyr Cys Leu Lys Arg Ile Gln Ala Met Ser Leu Lys Ala Ser 
        275                 280                 285             


Ser Tyr Ile Asp Asp Leu Ala Ala Ala Gly His Asp Val Ser Lys Leu 
    290                 295                 300                 


Arg Ala Ile Leu His Tyr Phe Val Ser Thr Ser Asp Cys Glu Glu Arg 
305                 310                 315                 320 


Lys Tyr Phe Glu Asp Ala Gln 
                325         


<210>  26
<211>  327
<212>  PRT
<213>  Artificial sequence

<220>
<223>  GGS variant

<400>  26

Met Asp Tyr Asn Ser Ala Asp Phe Lys Glu Ile Trp Gly Lys Ala Ala 
1               5                   10                  15      


Asp Thr Ala Leu Leu Gly Pro Tyr Asn Tyr Leu Ala Asn Asn Arg Gly 
            20                  25                  30          


His Asn Ile Arg Glu His Leu Ile Ala Ala Phe Gly Ala Val Ile Lys 
        35                  40                  45              


Val Asp Lys Ser Asp Leu Glu Thr Ile Ser His Ile Thr Lys Ile Leu 
    50                  55                  60                  


His Asn Ser Ser Leu Leu Val Asp Asp Val Glu Asp Asn Ser Met Leu 
65                  70                  75                  80  


Arg Arg Gly Leu Pro Ala Ala His Cys Leu Phe Gly Val Pro Gln Thr 
                85                  90                  95      


Ile Asn Ser Ala Asn Tyr Met Tyr Phe Val Ala Leu Gln Glu Val Leu 
            100                 105                 110         


Lys Leu Lys Ser Tyr Asp Ala Val Ser Ile Phe Thr Glu Glu Met Ile 
        115                 120                 125             


Asn Leu His Arg Gly Gln Gly Met Asp Leu Tyr Trp Arg Glu Thr Leu 
    130                 135                 140                 


Thr Cys Pro Ser Glu Asp Glu Tyr Leu Glu Met Val Val His Lys Thr 
145                 150                 155                 160 


Gly Gly Leu Phe Arg Leu Ala Leu Arg Leu Met Leu Ser Val Ala Ser 
                165                 170                 175     


Lys Gln Glu Asp His Glu Lys Ile Asn Phe Asp Leu Thr His Leu Thr 
            180                 185                 190         


Asp Thr Leu Gly Val Ile Tyr Gln Ile Leu Asp Asp Tyr Leu Asn Leu 
        195                 200                 205             


Gln Ser Thr Glu Leu Thr Glu Asn Lys Gly Phe Cys Glu Asp Ile Ser 
    210                 215                 220                 


Glu Gly Lys Phe Ser Phe Pro Leu Ile His Ala Ile Arg Thr Asn Pro 
225                 230                 235                 240 


Asp Asn His Glu Ile Leu Asn Ile Leu Lys Gln Arg Thr Ser Asp Ala 
                245                 250                 255     


Ser Leu Lys Lys Tyr Ala Val Asp Tyr Met Arg Thr Glu Thr Lys Ser 
            260                 265                 270         


Phe Asp Tyr Cys Leu Lys Arg Ile Gln Ala Met Ser Leu Lys Ala Ser 
        275                 280                 285             


Ser Tyr Ile Asp Asp Leu Ala Ala Ala Gly His Asp Val Ser Lys Leu 
    290                 295                 300                 


Arg Ala Ile Leu His Tyr Phe Val Ser Thr Ser Asp Cys Glu Glu Arg 
305                 310                 315                 320 


Lys Tyr Phe Glu Asp Ala Gln 
                325         


<210>  27
<211>  327
<212>  PRT
<213>  Artificial sequence

<220>
<223>  GGS variant

<400>  27

Met Asp Tyr Asn Ser Ala Asp Phe Lys Glu Ile Trp Gly Lys Ala Ala 
1               5                   10                  15      


Asp Thr Ala Leu Leu Gly Pro Tyr Asn Tyr Leu Ala Asn Asn Arg Gly 
            20                  25                  30          


His Asn Ile Arg Glu His Leu Ile Ala Ala Phe Gly Ala Val Ile Lys 
        35                  40                  45              


Val Asp Lys Ser Asp Leu Glu Thr Ile Ser His Ile Thr Lys Ile Leu 
    50                  55                  60                  


His Asn Ser Ser Leu Leu Val Asp Asp Val Glu Asp Asn Ser Met Leu 
65                  70                  75                  80  


Arg Arg Gly Leu Pro Ala Ala His Cys Leu Phe Gly Val Pro Gln Thr 
                85                  90                  95      


Ile Asn Ser Ala Asn Tyr Met Tyr Phe Val Ala Leu Gln Glu Val Leu 
            100                 105                 110         


Lys Leu Lys Ser Tyr Asp Ala Val Ser Ile Phe Thr Glu Glu Met Ile 
        115                 120                 125             


Asn Leu His Arg Gly Gln Gly Met Asp Leu Tyr Trp Arg Glu Thr Leu 
    130                 135                 140                 


Thr Cys Pro Ser Glu Asp Glu Tyr Leu Glu Met Val Val His Lys Thr 
145                 150                 155                 160 


Gly Gly Leu Phe Arg Leu Ala Leu Arg Leu Met Leu Ser Val Ala Ser 
                165                 170                 175     


Lys Gln Glu Asp His Glu Lys Ile Asn Phe Asp Leu Thr His Leu Thr 
            180                 185                 190         


Asp Thr Leu Gly Val Ile Tyr Gln Ile Leu Asp Asp Tyr Leu Asn Leu 
        195                 200                 205             


Gln Ser Thr Glu Leu Thr Glu Asn Lys Gly Phe Cys Glu Asp Ile Ser 
    210                 215                 220                 


Glu Gly Lys Phe Ser Phe Pro Leu Ile His Gly Ile Arg Thr Asn Pro 
225                 230                 235                 240 


Asp Asn His Glu Ile Leu Asn Ile Leu Lys Gln Arg Thr Ser Asp Ala 
                245                 250                 255     


Ser Leu Lys Lys Tyr Ala Val Asp Tyr Met Arg Thr Glu Thr Lys Ser 
            260                 265                 270         


Phe Asp Tyr Cys Leu Lys Arg Ile Gln Ala Met Ser Leu Lys Ala Ser 
        275                 280                 285             


Ser Tyr Ile Asp Asp Leu Ala Ala Ala Gly His Asp Val Ser Lys Leu 
    290                 295                 300                 


Arg Ala Ile Leu His Tyr Phe Val Ser Thr Ser Asp Cys Glu Glu Arg 
305                 310                 315                 320 


Lys Tyr Phe Glu Asp Ala Gln 
                325         


<210>  28
<211>  327
<212>  PRT
<213>  Artificial sequence

<220>
<223>  GGS variant

<400>  28

Met Asp Tyr Asn Ser Ala Asp Phe Lys Glu Ile Trp Gly Lys Ala Ala 
1               5                   10                  15      


Asp Thr Ala Leu Leu Gly Pro Tyr Asn Tyr Leu Ala Asn Asn Arg Gly 
            20                  25                  30          


His Asn Ile Arg Glu His Leu Ile Ala Ala Phe Gly Ala Val Ile Lys 
        35                  40                  45              


Val Asp Lys Ser Asp Leu Glu Thr Ile Ser His Ile Thr Lys Ile Leu 
    50                  55                  60                  


His Asn Ser Ser Leu Leu Val Asp Asp Val Glu Asp Asn Ser Met Leu 
65                  70                  75                  80  


Arg Arg Gly Leu Pro Ala Ala His Cys Leu Phe Gly Val Pro Gln Thr 
                85                  90                  95      


Ile Asn Ser Ala Asn Tyr Met Tyr Phe Val Ala Leu Gln Glu Val Leu 
            100                 105                 110         


Lys Leu Lys Ser Tyr Asp Ala Val Ser Ile Phe Thr Glu Glu Met Ile 
        115                 120                 125             


Asn Leu His Arg Gly Gln Gly Met Asp Leu Tyr Trp Arg Glu Thr Leu 
    130                 135                 140                 


Thr Cys Pro Ser Glu Asp Glu Tyr Leu Glu Met Val Val His Lys Thr 
145                 150                 155                 160 


Gly Gly Leu Phe Arg Leu Ala Leu Arg Leu Met Leu Ser Val Ala Ser 
                165                 170                 175     


Lys Gln Glu Asp His Glu Lys Ile Asn Phe Asp Leu Thr His Leu Thr 
            180                 185                 190         


Asp Thr Leu Gly Val Ile Tyr Gln Ile Leu Asp Asp Tyr Leu Asn Leu 
        195                 200                 205             


Gln Ser Thr Glu Leu Thr Glu Asn Lys Gly Phe Cys Glu Asp Ile Ser 
    210                 215                 220                 


Glu Gly Lys Phe Ser Phe Pro Leu Ile His Gln Ile Arg Thr Asn Pro 
225                 230                 235                 240 


Asp Asn His Glu Ile Leu Asn Ile Leu Lys Gln Arg Thr Ser Asp Ala 
                245                 250                 255     


Ser Leu Lys Lys Tyr Ala Val Asp Tyr Met Arg Thr Glu Thr Lys Ser 
            260                 265                 270         


Phe Asp Tyr Cys Leu Lys Arg Ile Gln Ala Met Ser Leu Lys Ala Ser 
        275                 280                 285             


Ser Tyr Ile Asp Asp Leu Ala Ala Ala Gly His Asp Val Ser Lys Leu 
    290                 295                 300                 


Arg Ala Ile Leu His Tyr Phe Val Ser Thr Ser Asp Cys Glu Glu Arg 
305                 310                 315                 320 


Lys Tyr Phe Glu Asp Ala Gln 
                325         


<210>  29
<211>  327
<212>  PRT
<213>  Artificial sequence

<220>
<223>  GGS variant

<400>  29

Met Asp Tyr Asn Ser Ala Asp Phe Lys Glu Ile Trp Gly Lys Ala Ala 
1               5                   10                  15      


Asp Thr Ala Leu Leu Gly Pro Tyr Asn Tyr Leu Ala Asn Asn Arg Gly 
            20                  25                  30          


His Asn Ile Arg Glu His Leu Ile Ala Ala Phe Gly Ala Val Ile Lys 
        35                  40                  45              


Val Asp Lys Ser Asp Leu Glu Thr Ile Ser His Ile Thr Lys Ile Leu 
    50                  55                  60                  


His Asn Ser Ser Leu Leu Val Asp Asp Val Glu Asp Asn Ser Met Leu 
65                  70                  75                  80  


Arg Arg Gly Leu Pro Ala Ala His Cys Leu Phe Gly Val Pro Gln Thr 
                85                  90                  95      


Ile Asn Ser Ala Asn Tyr Met Tyr Phe Val Ala Leu Gln Glu Val Leu 
            100                 105                 110         


Lys Leu Lys Ser Tyr Asp Ala Val Ser Ile Phe Thr Glu Glu Met Ile 
        115                 120                 125             


Asn Leu His Arg Gly Gln Gly Met Asp Leu Tyr Trp Arg Glu Thr Leu 
    130                 135                 140                 


Thr Cys Pro Ser Glu Asp Glu Tyr Leu Glu Met Val Val His Lys Thr 
145                 150                 155                 160 


Gly Gly Leu Phe Arg Leu Ala Leu Arg Leu Met Leu Ser Val Ala Ser 
                165                 170                 175     


Lys Gln Glu Asp His Glu Lys Ile Asn Phe Asp Leu Thr His Leu Thr 
            180                 185                 190         


Asp Thr Leu Gly Val Ile Tyr Gln Ile Leu Asp Asp Tyr Leu Asn Leu 
        195                 200                 205             


Gln Ser Thr Glu Leu Thr Glu Asn Lys Gly Phe Cys Glu Asp Ile Ser 
    210                 215                 220                 


Glu Gly Lys Phe Ser Phe Pro Leu Ile His Val Ile Arg Thr Asn Pro 
225                 230                 235                 240 


Asp Asn His Glu Ile Leu Asn Ile Leu Lys Gln Arg Thr Ser Asp Ala 
                245                 250                 255     


Ser Leu Lys Lys Tyr Ala Val Asp Tyr Met Arg Thr Glu Thr Lys Ser 
            260                 265                 270         


Phe Asp Tyr Cys Leu Lys Arg Ile Gln Ala Met Ser Leu Lys Ala Ser 
        275                 280                 285             


Ser Tyr Ile Asp Asp Leu Ala Ala Ala Gly His Asp Val Ser Lys Leu 
    290                 295                 300                 


Arg Ala Ile Leu His Tyr Phe Val Ser Thr Ser Asp Cys Glu Glu Arg 
305                 310                 315                 320 


Lys Tyr Phe Glu Asp Ala Gln 
                325         


<210>  30
<211>  327
<212>  PRT
<213>  Artificial sequence

<220>
<223>  GGS variant

<400>  30

Met Asp Tyr Asn Ser Ala Asp Phe Lys Glu Ile Trp Gly Lys Ala Ala 
1               5                   10                  15      


Asp Thr Ala Leu Leu Gly Pro Tyr Asn Tyr Leu Ala Asn Asn Arg Gly 
            20                  25                  30          


His Asn Ile Arg Glu His Leu Ile Ala Ala Phe Gly Ala Val Ile Lys 
        35                  40                  45              


Val Asp Lys Ser Asp Leu Glu Thr Ile Ser His Ile Thr Lys Ile Leu 
    50                  55                  60                  


His Asn Ser Ser Leu Leu Val Asp Asp Val Glu Asp Asn Ser Met Leu 
65                  70                  75                  80  


Arg Arg Gly Leu Pro Ala Ala His Cys Leu Phe Gly Val Pro Gln Thr 
                85                  90                  95      


Ile Asn Ser Ala Asn Tyr Met Tyr Phe Val Ala Leu Gln Glu Val Leu 
            100                 105                 110         


Lys Leu Lys Ser Tyr Asp Ala Val Ser Ile Phe Thr Glu Glu Met Ile 
        115                 120                 125             


Asn Leu His Arg Gly Gln Gly Met Asp Leu Tyr Trp Arg Glu Thr Leu 
    130                 135                 140                 


Thr Cys Pro Ser Glu Asp Glu Tyr Leu Glu Met Val Val His Lys Thr 
145                 150                 155                 160 


Gly Gly Leu Phe Arg Leu Ala Leu Arg Leu Met Leu Ser Val Ala Ser 
                165                 170                 175     


Lys Gln Glu Asp His Glu Lys Ile Asn Phe Asp Leu Thr His Leu Thr 
            180                 185                 190         


Asp Thr Leu Gly Val Ile Tyr Gln Ile Leu Asp Asp Tyr Leu Asn Leu 
        195                 200                 205             


Gln Ser Thr Glu Leu Thr Glu Asn Lys Gly Phe Cys Glu Asp Ile Ser 
    210                 215                 220                 


Glu Gly Lys Phe Ser Phe Pro Leu Ile His Asp Ile Arg Thr Asn Pro 
225                 230                 235                 240 


Asp Asn His Glu Ile Leu Asn Ile Leu Lys Gln Arg Thr Ser Asp Ala 
                245                 250                 255     


Ser Leu Lys Lys Tyr Ala Val Asp Tyr Met Arg Thr Glu Thr Lys Ser 
            260                 265                 270         


Phe Asp Tyr Cys Leu Lys Arg Ile Gln Ala Met Ser Leu Lys Ala Ser 
        275                 280                 285             


Ser Tyr Ile Asp Asp Leu Ala Ala Ala Gly His Asp Val Ser Lys Leu 
    290                 295                 300                 


Arg Ala Ile Leu His Tyr Phe Val Ser Thr Ser Asp Cys Glu Glu Arg 
305                 310                 315                 320 


Lys Tyr Phe Glu Asp Ala Gln 
                325         


<210>  31
<211>  327
<212>  PRT
<213>  Artificial sequence

<220>
<223>  GGS variant

<400>  31

Met Asp Tyr Asn Ser Ala Asp Phe Lys Glu Ile Trp Gly Lys Ala Ala 
1               5                   10                  15      


Asp Thr Ala Leu Leu Gly Pro Tyr Asn Tyr Leu Ala Asn Asn Arg Gly 
            20                  25                  30          


His Asn Ile Arg Glu His Leu Ile Ala Ala Phe Gly Ala Val Ile Lys 
        35                  40                  45              


Val Asp Lys Ser Asp Leu Glu Thr Ile Ser His Ile Thr Lys Ile Leu 
    50                  55                  60                  


His Asn Ser Ser Leu Leu Val Asp Asp Val Glu Asp Asn Ser Met Leu 
65                  70                  75                  80  


Arg Arg Gly Leu Pro Ala Ala His Cys Leu Phe Gly Val Pro Gln Thr 
                85                  90                  95      


Ile Asn Ser Ala Asn Tyr Met Tyr Phe Val Ala Leu Gln Glu Val Leu 
            100                 105                 110         


Lys Leu Lys Ser Tyr Asp Ala Val Ser Ile Phe Thr Glu Glu Met Ile 
        115                 120                 125             


Asn Leu His Arg Gly Gln Gly Met Asp Leu Tyr Trp Arg Glu Thr Leu 
    130                 135                 140                 


Thr Cys Pro Ser Glu Asp Glu Tyr Leu Glu Met Val Val His Lys Thr 
145                 150                 155                 160 


Gly Gly Leu Phe Arg Leu Ala Leu Arg Leu Met Leu Ser Val Ala Ser 
                165                 170                 175     


Lys Gln Glu Asp His Glu Lys Ile Asn Phe Asp Leu Thr His Leu Thr 
            180                 185                 190         


Asp Thr Leu Gly Val Ile Tyr Gln Ile Leu Asp Asp Tyr Leu Asn Leu 
        195                 200                 205             


Gln Ser Thr Glu Leu Thr Glu Asn Lys Gly Phe Cys Glu Asp Ile Ser 
    210                 215                 220                 


Glu Gly Lys Phe Ser Phe Pro Leu Ile His Glu Ile Arg Thr Asn Pro 
225                 230                 235                 240 


Asp Asn His Glu Ile Leu Asn Ile Leu Lys Gln Arg Thr Ser Asp Ala 
                245                 250                 255     


Ser Leu Lys Lys Tyr Ala Val Asp Tyr Met Arg Thr Glu Thr Lys Ser 
            260                 265                 270         


Phe Asp Tyr Cys Leu Lys Arg Ile Gln Ala Met Ser Leu Lys Ala Ser 
        275                 280                 285             


Ser Tyr Ile Asp Asp Leu Ala Ala Ala Gly His Asp Val Ser Lys Leu 
    290                 295                 300                 


Arg Ala Ile Leu His Tyr Phe Val Ser Thr Ser Asp Cys Glu Glu Arg 
305                 310                 315                 320 


Lys Tyr Phe Glu Asp Ala Gln 
                325         


<210>  32
<211>  327
<212>  PRT
<213>  Artificial sequence

<220>
<223>  GGS variant

<400>  32

Met Asp Tyr Asn Ser Ala Asp Phe Lys Glu Ile Trp Gly Lys Ala Ala 
1               5                   10                  15      


Asp Thr Ala Leu Leu Gly Pro Tyr Asn Tyr Leu Ala Asn Asn Arg Gly 
            20                  25                  30          


His Asn Ile Arg Glu His Leu Ile Ala Ala Phe Gly Ala Val Ile Lys 
        35                  40                  45              


Val Asp Lys Ser Asp Leu Glu Thr Ile Ser His Ile Thr Lys Ile Leu 
    50                  55                  60                  


His Asn Ser Ser Leu Leu Val Asp Asp Val Glu Asp Asn Ser Met Leu 
65                  70                  75                  80  


Arg Arg Gly Leu Pro Ala Ala His Cys Leu Phe Gly Val Pro Gln Thr 
                85                  90                  95      


Ile Asn Ser Ala Asn Tyr Met Tyr Phe Val Ala Leu Gln Glu Val Leu 
            100                 105                 110         


Lys Leu Lys Ser Tyr Asp Ala Val Ser Ile Phe Thr Glu Glu Met Ile 
        115                 120                 125             


Asn Leu His Arg Gly Gln Gly Met Asp Leu Tyr Trp Arg Glu Thr Leu 
    130                 135                 140                 


Thr Cys Pro Ser Glu Asp Glu Tyr Leu Glu Met Val Val His Lys Thr 
145                 150                 155                 160 


Gly Gly Leu Phe Arg Leu Ala Leu Arg Leu Met Leu Ser Val Ala Ser 
                165                 170                 175     


Lys Gln Glu Asp His Glu Lys Ile Asn Phe Asp Leu Thr His Leu Thr 
            180                 185                 190         


Asp Thr Leu Gly Val Ile Tyr Gln Ile Leu Asp Asp Tyr Leu Asn Leu 
        195                 200                 205             


Gln Ser Thr Glu Leu Thr Glu Asn Lys Gly Phe Cys Glu Asp Ile Ser 
    210                 215                 220                 


Glu Gly Lys Phe Ser Phe Pro Leu Ile His Phe Ile Arg Thr Asn Pro 
225                 230                 235                 240 


Asp Asn His Glu Ile Leu Asn Ile Leu Lys Gln Arg Thr Ser Asp Ala 
                245                 250                 255     


Ser Leu Lys Lys Tyr Ala Val Asp Tyr Met Arg Thr Glu Thr Lys Ser 
            260                 265                 270         


Phe Asp Tyr Cys Leu Lys Arg Ile Gln Ala Met Ser Leu Lys Ala Ser 
        275                 280                 285             


Ser Tyr Ile Asp Asp Leu Ala Ala Ala Gly His Asp Val Ser Lys Leu 
    290                 295                 300                 


Arg Ala Ile Leu His Tyr Phe Val Ser Thr Ser Asp Cys Glu Glu Arg 
305                 310                 315                 320 


Lys Tyr Phe Glu Asp Ala Gln 
                325         


<210>  33
<211>  327
<212>  PRT
<213>  Artificial sequence

<220>
<223>  GGS variant

<400>  33

Met Asp Tyr Asn Ser Ala Asp Phe Lys Glu Ile Trp Gly Lys Ala Ala 
1               5                   10                  15      


Asp Thr Ala Leu Leu Gly Pro Tyr Asn Tyr Leu Ala Asn Asn Arg Gly 
            20                  25                  30          


His Asn Ile Arg Glu His Leu Ile Ala Ala Phe Gly Ala Val Ile Lys 
        35                  40                  45              


Val Asp Lys Ser Asp Leu Glu Thr Ile Ser His Ile Thr Lys Ile Leu 
    50                  55                  60                  


His Asn Ser Ser Leu Leu Val Asp Asp Val Glu Asp Asn Ser Met Leu 
65                  70                  75                  80  


Arg Arg Gly Leu Pro Ala Ala His Cys Leu Phe Gly Val Pro Gln Thr 
                85                  90                  95      


Ile Asn Ser Ala Asn Tyr Met Tyr Phe Val Ala Leu Gln Glu Val Leu 
            100                 105                 110         


Lys Leu Lys Ser Tyr Asp Ala Val Ser Ile Phe Thr Glu Glu Met Ile 
        115                 120                 125             


Asn Leu His Arg Gly Gln Gly Met Asp Leu Tyr Trp Arg Glu Thr Leu 
    130                 135                 140                 


Thr Cys Pro Ser Glu Asp Glu Tyr Leu Glu Met Val Val His Lys Thr 
145                 150                 155                 160 


Gly Gly Leu Phe Arg Leu Ala Leu Arg Leu Met Leu Ser Val Ala Ser 
                165                 170                 175     


Lys Gln Glu Asp His Glu Lys Ile Asn Phe Asp Leu Thr His Leu Thr 
            180                 185                 190         


Asp Thr Leu Gly Val Ile Tyr Gln Ile Leu Asp Asp Tyr Leu Asn Leu 
        195                 200                 205             


Gln Ser Thr Glu Leu Thr Glu Asn Lys Gly Phe Cys Glu Asp Ile Ser 
    210                 215                 220                 


Glu Gly Lys Phe Ser Phe Pro Leu Ile His Tyr Ile Arg Thr Asn Pro 
225                 230                 235                 240 


Asp Asn His Glu Ile Leu Asn Ile Leu Lys Gln Arg Thr Ser Asp Ala 
                245                 250                 255     


Ser Leu Lys Lys Tyr Ala Val Asp Tyr Met Arg Thr Glu Thr Lys Ser 
            260                 265                 270         


Phe Asp Tyr Cys Leu Lys Arg Ile Gln Ala Met Ser Leu Lys Ala Ser 
        275                 280                 285             


Ser Tyr Ile Asp Asp Leu Ala Ala Ala Gly His Asp Val Ser Lys Leu 
    290                 295                 300                 


Arg Ala Ile Leu His Tyr Phe Val Ser Thr Ser Asp Cys Glu Glu Arg 
305                 310                 315                 320 


Lys Tyr Phe Glu Asp Ala Gln 
                325         


