                               SEQUENCE LISTING

<110> ADIMAB LLC
 
<120> ANTI-RESPIRATORY SYNCYTIAL VIRUS ANTIBODIES, AND METHODS OF THEIR
      GENERATION AND USE

<130> 2009186-0218

<140>
<141>

<150> 62/411,508
<151> 2016-10-21

<160> 2224  

<170> PatentIn version 3.5

<210> 1
<211> 378
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region"

<400> 1
caggtgcagc tacagcagtg gggcgcagga ctgttgaagc cttcggagac cctgtccctc       60

acctgcgctg tctatggtgg gtccttcagt ggttattcct ggagctggat ccgccagacc      120

ccagggaagg ggctggagtg gattggggaa atcaatcata gaggaagcac caactacaac      180

ccgtccctca agagtcgagt caccatgtca gtggacacgt cccagaacca gatctccctg      240

agggtgacct ctgtgaccgc cgcggacacg gctgtatatt tctgtgcggg gaccaattat      300

ggagaggtta atacgagtaa ccagtacttc ttcggtatgg acgtctgggg ccaagggacc      360

acggtcaccg tctcctca                                                    378


<210> 2
<211> 126
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region"

<400> 2
Gln Val Gln Leu Gln Gln Trp Gly Ala Gly Leu Leu Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Ala Val Tyr Gly Gly Ser Phe Ser Gly Tyr 
            20                  25                  30          


Ser Trp Ser Trp Ile Arg Gln Thr Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Glu Ile Asn His Arg Gly Ser Thr Asn Tyr Asn Pro Ser Leu Lys 
    50                  55                  60                  


Ser Arg Val Thr Met Ser Val Asp Thr Ser Gln Asn Gln Ile Ser Leu 
65                  70                  75                  80  


Arg Val Thr Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Phe Cys Ala 
                85                  90                  95      


Gly Thr Asn Tyr Gly Glu Val Asn Thr Ser Asn Gln Tyr Phe Phe Gly 
            100                 105                 110         


Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120                 125     


<210> 3
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H1"

<400> 3
Gly Ser Phe Ser Gly Tyr Ser Trp Ser 
1               5                   


<210> 4
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H1"

<400> 4
gggtccttca gtggttattc ctggagc                                           27


<210> 5
<211> 16
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H2"

<400> 5
Glu Ile Asn His Arg Gly Ser Thr Asn Tyr Asn Pro Ser Leu Lys Ser 
1               5                   10                  15      


<210> 6
<211> 48
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H2"

<400> 6
gaaatcaatc atagaggaag caccaactac aacccgtccc tcaagagt                    48


<210> 7
<211> 20
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H3"

<400> 7
Ala Gly Thr Asn Tyr Gly Glu Val Asn Thr Ser Asn Gln Tyr Phe Phe 
1               5                   10                  15      


Gly Met Asp Val 
            20  


<210> 8
<211> 60
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H3"

<400> 8
gcggggacca attatggaga ggttaatacg agtaaccagt acttcttcgg tatggacgtc       60


<210> 9
<211> 321
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region"

<400> 9
gacatccagg tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga cagagtcacc       60

atcacttgcc gggcaagtca gagcattggc acctatttaa attggtatca gcagaaacca      120

gggaaacccc ctaaactcct gatctatgct gcatccaatt tggaaagtgg ggtcccatca      180

agtttcagtg gcagtggatc tgggacacat ttcactctca ccatcagcag tctgcaacct      240

gaacattttg caacttacta ctgtcaacag agttacagta ccccgctcac tttcggcgga      300

gggaccaagg tggaaatcaa a                                                321


<210> 10
<211> 107
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region"

<400> 10
Asp Ile Gln Val Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Gly Thr Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Pro Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Asn Leu Glu Ser Gly Val Pro Ser Ser Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr His Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu His Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Tyr Ser Thr Pro Leu 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210> 11
<211> 11
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L1"

<400> 11
Arg Ala Ser Gln Ser Ile Gly Thr Tyr Leu Asn 
1               5                   10      


<210> 12
<211> 33
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L1"

<400> 12
cgggcaagtc agagcattgg cacctattta aat                                    33


<210> 13
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L2"

<400> 13
Ala Ala Ser Asn Leu Glu Ser 
1               5           


<210> 14
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L2"

<400> 14
gctgcatcca atttggaaag t                                                 21


<210> 15
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L3"

<400> 15
Gln Gln Ser Tyr Ser Thr Pro Leu Thr 
1               5                   


<210> 16
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L3"

<400> 16
caacagagtt acagtacccc gctcact                                           27


<210> 17
<211> 384
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region"

<400> 17
caggtgcagc tgcaggagtc gggcccagga ctggtgaagc cttcacagac cctgtccctc       60

acctgcactg tctctggtcc ctccatcagc agtggtgatt actactggac ttggatccgc      120

cagcccccag ggaagggcct ggagtggatt ggctacatct ataacagtgg gagcaccgac      180

tacaacccgt ccctcaagag tcgtatcacc atgtcactag acaggtccaa gaaccagttc      240

tccctgaatc tgagctctgt gactgccgca gacacggccg tgtatttctg tgccagggat      300

gtgggtactc tggtactacc aactgttgct tactactacg gcatggacgt ctggggccaa      360

gggaccacgg tcaccgtctc ctca                                             384


<210> 18
<211> 128
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region"

<400> 18
Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Pro Ser Ile Ser Ser Gly 
            20                  25                  30          


Asp Tyr Tyr Trp Thr Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu 
        35                  40                  45              


Trp Ile Gly Tyr Ile Tyr Asn Ser Gly Ser Thr Asp Tyr Asn Pro Ser 
    50                  55                  60                  


Leu Lys Ser Arg Ile Thr Met Ser Leu Asp Arg Ser Lys Asn Gln Phe 
65                  70                  75                  80  


Ser Leu Asn Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Phe 
                85                  90                  95      


Cys Ala Arg Asp Val Gly Thr Leu Val Leu Pro Thr Val Ala Tyr Tyr 
            100                 105                 110         


Tyr Gly Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120                 125             


<210> 19
<211> 11
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H1"

<400> 19
Pro Ser Ile Ser Ser Gly Asp Tyr Tyr Trp Thr 
1               5                   10      


<210> 20
<211> 33
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H1"

<400> 20
ccctccatca gcagtggtga ttactactgg act                                    33


<210> 21
<211> 16
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H2"

<400> 21
Tyr Ile Tyr Asn Ser Gly Ser Thr Asp Tyr Asn Pro Ser Leu Lys Ser 
1               5                   10                  15      


<210> 22
<211> 48
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H2"

<400> 22
tacatctata acagtgggag caccgactac aacccgtccc tcaagagt                    48


<210> 23
<211> 20
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H3"

<400> 23
Ala Arg Asp Val Gly Thr Leu Val Leu Pro Thr Val Ala Tyr Tyr Tyr 
1               5                   10                  15      


Gly Met Asp Val 
            20  


<210> 24
<211> 60
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H3"

<400> 24
gccagggatg tgggtactct ggtactacca actgttgctt actactacgg catggacgtc       60


<210> 25
<211> 327
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region"

<400> 25
gaaattgtat tgacgcagtc tccaggcacc ctgtctttgt ctccggggga aagagccacc       60

ctctcctgca gggccagtga gagtattagc agcagctact tagcctggta ccagcagaaa      120

cctggccagg ctcccagact cctcatctat gatgcgtcca gcagggccac tggcatccca      180

gacaggttca gtggcagtgg gtctgggaca gacttcactc tcaccatcag cagtctggag      240

cctgaagatt ttgcagtgta ttactgtcag cagtatggta gctcacccct ggtcactttc      300

ggccctggga ccaaagtgga tatcaaa                                          327


<210> 26
<211> 109
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region"

<400> 26
Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Glu Ser Ile Ser Ser Ser 
            20                  25                  30          


Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu 
        35                  40                  45              


Ile Tyr Asp Ala Ser Ser Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu 
65                  70                  75                  80  


Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Gly Ser Ser Pro 
                85                  90                  95      


Leu Val Thr Phe Gly Pro Gly Thr Lys Val Asp Ile Lys 
            100                 105                 


<210> 27
<211> 12
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L1"

<400> 27
Arg Ala Ser Glu Ser Ile Ser Ser Ser Tyr Leu Ala 
1               5                   10          


<210> 28
<211> 36
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L1"

<400> 28
agggccagtg agagtattag cagcagctac ttagcc                                 36


<210> 29
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L2"

<400> 29
Asp Ala Ser Ser Arg Ala Thr 
1               5           


<210> 30
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L2"

<400> 30
gatgcgtcca gcagggccac t                                                 21


<210> 31
<211> 10
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L3"

<400> 31
Gln Gln Tyr Gly Ser Ser Pro Leu Val Thr 
1               5                   10  


<210> 32
<211> 30
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L3"

<400> 32
cagcagtatg gtagctcacc cctggtcact                                        30


<210> 33
<211> 363
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region"

<400> 33
caggtccagc tggtgcagtc tggaactgag gtgaagaagc ctggggcctc agtgaaggtc       60

tcctgtaagg ctgctggtta cacctttagc aactacggtg tcagttgggt gcgacaggcc      120

cctggacagg ggcttgagtg gatgggatgg atcagcgctt ataatggtaa cacaaaattt      180

gcacagaagg tccagggcag actcaccatg accacagaca catctaccag cacagcctac      240

atggaattga ggaacctcag atctgacgac acggccgtgt attattgtgc gagagaatca      300

ggggcaacag cggctgctat gtttgactac tggggccagg gaaccctggt caccgtctcc      360

tca                                                                    363


<210> 34
<211> 121
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region"

<400> 34
Gln Val Gln Leu Val Gln Ser Gly Thr Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ala Gly Tyr Thr Phe Ser Asn Tyr 
            20                  25                  30          


Gly Val Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Ser Ala Tyr Asn Gly Asn Thr Lys Phe Ala Gln Lys Val 
    50                  55                  60                  


Gln Gly Arg Leu Thr Met Thr Thr Asp Thr Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Arg Asn Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Glu Ser Gly Ala Thr Ala Ala Ala Met Phe Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120     


<210> 35
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H1"

<400> 35
Tyr Thr Phe Ser Asn Tyr Gly Val Ser 
1               5                   


<210> 36
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H1"

<400> 36
tacaccttta gcaactacgg tgtcagt                                           27


<210> 37
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H2"

<400> 37
Trp Ile Ser Ala Tyr Asn Gly Asn Thr Lys Phe Ala Gln Lys Val Gln 
1               5                   10                  15      


Gly 
    


<210> 38
<211> 51
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H2"

<400> 38
tggatcagcg cttataatgg taacacaaaa tttgcacaga aggtccaggg c                51


<210> 39
<211> 14
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H3"

<400> 39
Ala Arg Glu Ser Gly Ala Thr Ala Ala Ala Met Phe Asp Tyr 
1               5                   10                  


<210> 40
<211> 42
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H3"

<400> 40
gcgagagaat caggggcaac agcggctgct atgtttgact ac                          42


<210> 41
<211> 336
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region"

<400> 41
gaaacgacac tcacgcagtc tccactctcc ctgcccgtca cccttggaca gccggcctcc       60

atctcctgca ggtctagtca aagcctcgaa tacagtgatg gaaacatcta cttgagttgg      120

tttcaacaga ggccaggcca atctccaagg cgcctaattt ataaggtttc tcaccgggac      180

tctggggtcc cagacagatt cagcggcagt gggtcaggca ctgatttcac actgaaaatc      240

gccagggtgg aggctgagga tgttgcagtt tattactgca tgcaagctat acactggcct      300

cgaacttttg gccaggggac caaagtggat atcaaa                                336


<210> 42
<211> 112
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region"

<400> 42
Glu Thr Thr Leu Thr Gln Ser Pro Leu Ser Leu Pro Val Thr Leu Gly 
1               5                   10                  15      


Gln Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Glu Tyr Ser 
            20                  25                  30          


Asp Gly Asn Ile Tyr Leu Ser Trp Phe Gln Gln Arg Pro Gly Gln Ser 
        35                  40                  45              


Pro Arg Arg Leu Ile Tyr Lys Val Ser His Arg Asp Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ala Arg Val Glu Ala Glu Asp Val Ala Val Tyr Tyr Cys Met Gln Ala 
                85                  90                  95      


Ile His Trp Pro Arg Thr Phe Gly Gln Gly Thr Lys Val Asp Ile Lys 
            100                 105                 110         


<210> 43
<211> 16
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L1"

<400> 43
Arg Ser Ser Gln Ser Leu Glu Tyr Ser Asp Gly Asn Ile Tyr Leu Ser 
1               5                   10                  15      


<210> 44
<211> 48
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L1"

<400> 44
aggtctagtc aaagcctcga atacagtgat ggaaacatct acttgagt                    48


<210> 45
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L2"

<400> 45
Lys Val Ser His Arg Asp Ser 
1               5           


<210> 46
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L2"

<400> 46
aaggtttctc accgggactc t                                                 21


<210> 47
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L3"

<400> 47
Met Gln Ala Ile His Trp Pro Arg Thr 
1               5                   


<210> 48
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L3"

<400> 48
atgcaagcta tacactggcc tcgaact                                           27


<210> 49
<211> 378
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region"

<400> 49
caggtgcagc tgcaggagtc gggcccaaga ctggtgaagc cttcacagac cctgtccctc       60

atctgcgatg tctctggtgg ctccatcggc agtggtgacc actactggag ttggatccgc      120

cagccccccg ggaagggcct cgagtggatt gggtacatct attacagtgg gaccacttac      180

tacaacccgt ccctcaagag tcgagtgacc atttcagcag acacgtccaa gaaccagttg      240

tccctgaaat tgagttctgt gactgccgca gacacggcca tttatttctg tgccagagat      300

gggggttatg atcacgtctg ggggactcat cgttatttcg acaagtgggg ccagggaacc      360

ctggtcaccg tctcctca                                                    378


<210> 50
<211> 126
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region"

<400> 50
Gln Val Gln Leu Gln Glu Ser Gly Pro Arg Leu Val Lys Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Ile Cys Asp Val Ser Gly Gly Ser Ile Gly Ser Gly 
            20                  25                  30          


Asp His Tyr Trp Ser Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu 
        35                  40                  45              


Trp Ile Gly Tyr Ile Tyr Tyr Ser Gly Thr Thr Tyr Tyr Asn Pro Ser 
    50                  55                  60                  


Leu Lys Ser Arg Val Thr Ile Ser Ala Asp Thr Ser Lys Asn Gln Leu 
65                  70                  75                  80  


Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Ile Tyr Phe 
                85                  90                  95      


Cys Ala Arg Asp Gly Gly Tyr Asp His Val Trp Gly Thr His Arg Tyr 
            100                 105                 110         


Phe Asp Lys Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125     


<210> 51
<211> 11
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H1"

<400> 51
Gly Ser Ile Gly Ser Gly Asp His Tyr Trp Ser 
1               5                   10      


<210> 52
<211> 33
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H1"

<400> 52
ggctccatcg gcagtggtga ccactactgg agt                                    33


<210> 53
<211> 16
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H2"

<400> 53
Tyr Ile Tyr Tyr Ser Gly Thr Thr Tyr Tyr Asn Pro Ser Leu Lys Ser 
1               5                   10                  15      


<210> 54
<211> 48
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H2"

<400> 54
tacatctatt acagtgggac cacttactac aacccgtccc tcaagagt                    48


<210> 55
<211> 18
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H3"

<400> 55
Ala Arg Asp Gly Gly Tyr Asp His Val Trp Gly Thr His Arg Tyr Phe 
1               5                   10                  15      


Asp Lys 
        


<210> 56
<211> 54
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H3"

<400> 56
gccagagatg ggggttatga tcacgtctgg gggactcatc gttatttcga caag             54


<210> 57
<211> 324
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region"

<400> 57
gaaattgtat tgacacagtc tccaggcacc ctgtctttgt ctcccgggga aagagccacc       60

ctctcctgca gggccagtca gagtgttagc aacagttact tagcctggta ccagcagaaa      120

cctggccagg ctcccaggct cctcatctat ggtgtttcca ccagggccac tggcatccca      180

gaccggttca gtggcagcgg gtctgggaca gacttcaccc tcaccatcag cagactggaa      240

cctgaagatt ttgcaatgta tcactgtcag cagtatggtg cctcaccttg gacgttcggc      300

caagggacca aagtggatat caaa                                             324


<210> 58
<211> 108
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region"

<400> 58
Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Asn Ser 
            20                  25                  30          


Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu 
        35                  40                  45              


Ile Tyr Gly Val Ser Thr Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu 
65                  70                  75                  80  


Pro Glu Asp Phe Ala Met Tyr His Cys Gln Gln Tyr Gly Ala Ser Pro 
                85                  90                  95      


Trp Thr Phe Gly Gln Gly Thr Lys Val Asp Ile Lys 
            100                 105             


<210> 59
<211> 12
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L1"

<400> 59
Arg Ala Ser Gln Ser Val Ser Asn Ser Tyr Leu Ala 
1               5                   10          


<210> 60
<211> 36
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L1"

<400> 60
agggccagtc agagtgttag caacagttac ttagcc                                 36


<210> 61
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L2"

<400> 61
Gly Val Ser Thr Arg Ala Thr 
1               5           


<210> 62
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L2"

<400> 62
ggtgtttcca ccagggccac t                                                 21


<210> 63
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L3"

<400> 63
Gln Gln Tyr Gly Ala Ser Pro Trp Thr 
1               5                   


<210> 64
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L3"

<400> 64
cagcagtatg gtgcctcacc ttggacg                                           27


<210> 65
<211> 363
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region"

<400> 65
gaggtgcagc tgttggagtc tggaggtgag gtgaagaagc ctggggcctc agtgaaggtc       60

tcctgcaggg cctctggtta cacctttaga aactatggcc tcacctgggt gcggcaggcc      120

cccggacaag ggcttgagtg gatgggatgg atcagcgctt acaatggaaa cacaaactat      180

gcacagaagt tccagggcag agtcacactg accacggaca catccacgag cacagcctac      240

atggaactga ggagcctaag atctgacgac acggccgtgt atttctgtgc gagagacgtc      300

cccggccacg gcgctgcctt catggacgtc tggggcacag ggaccacggt caccgtctcc      360

tca                                                                    363


<210> 66
<211> 121
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region"

<400> 66
Glu Val Gln Leu Leu Glu Ser Gly Gly Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Arg Ala Ser Gly Tyr Thr Phe Arg Asn Tyr 
            20                  25                  30          


Gly Leu Thr Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Ser Ala Tyr Asn Gly Asn Thr Asn Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Leu Thr Thr Asp Thr Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Arg Ser Leu Arg Ser Asp Asp Thr Ala Val Tyr Phe Cys 
                85                  90                  95      


Ala Arg Asp Val Pro Gly His Gly Ala Ala Phe Met Asp Val Trp Gly 
            100                 105                 110         


Thr Gly Thr Thr Val Thr Val Ser Ser 
        115                 120     


<210> 67
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H1"

<400> 67
Tyr Thr Phe Arg Asn Tyr Gly Leu Thr 
1               5                   


<210> 68
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H1"

<400> 68
tacaccttta gaaactatgg cctcacc                                           27


<210> 69
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H2"

<400> 69
Trp Ile Ser Ala Tyr Asn Gly Asn Thr Asn Tyr Ala Gln Lys Phe Gln 
1               5                   10                  15      


Gly 
    


<210> 70
<211> 51
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H2"

<400> 70
tggatcagcg cttacaatgg aaacacaaac tatgcacaga agttccaggg c                51


<210> 71
<211> 14
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H3"

<400> 71
Ala Arg Asp Val Pro Gly His Gly Ala Ala Phe Met Asp Val 
1               5                   10                  


<210> 72
<211> 42
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H3"

<400> 72
gcgagagacg tccccggcca cggcgctgcc ttcatggacg tc                          42


<210> 73
<211> 336
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region"

<400> 73
gacatccagt tgacccagtc tccactctcc ctgcccgtca cccttgggca gccggcctcc       60

atctcctgca ggtctagtca aagcctcgaa gccagtgata caaatatcta cttgagttgg      120

tttcagcaga ggccaggcca atctccaagg cgcctaattt ataagatttc taaccgagac      180

tctggggtcc cagacagatt cagcggcagt gggtcaggca ctcatttcac actgagaatc      240

agcagggtgg aggctgacga tgttgcggtt tattactgca tgcagggtac acactggcct      300

ccggcgttcg gccaggggac caaagtggat atcaaa                                336


<210> 74
<211> 112
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region"

<400> 74
Asp Ile Gln Leu Thr Gln Ser Pro Leu Ser Leu Pro Val Thr Leu Gly 
1               5                   10                  15      


Gln Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Glu Ala Ser 
            20                  25                  30          


Asp Thr Asn Ile Tyr Leu Ser Trp Phe Gln Gln Arg Pro Gly Gln Ser 
        35                  40                  45              


Pro Arg Arg Leu Ile Tyr Lys Ile Ser Asn Arg Asp Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr His Phe Thr Leu Arg Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Asp Asp Val Ala Val Tyr Tyr Cys Met Gln Gly 
                85                  90                  95      


Thr His Trp Pro Pro Ala Phe Gly Gln Gly Thr Lys Val Asp Ile Lys 
            100                 105                 110         


<210> 75
<211> 16
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L1"

<400> 75
Arg Ser Ser Gln Ser Leu Glu Ala Ser Asp Thr Asn Ile Tyr Leu Ser 
1               5                   10                  15      


<210> 76
<211> 48
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L1"

<400> 76
aggtctagtc aaagcctcga agccagtgat acaaatatct acttgagt                    48


<210> 77
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L2"

<400> 77
Lys Ile Ser Asn Arg Asp Ser 
1               5           


<210> 78
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L2"

<400> 78
aagatttcta accgagactc t                                                 21


<210> 79
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L3"

<400> 79
Met Gln Gly Thr His Trp Pro Pro Ala 
1               5                   


<210> 80
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L3"

<400> 80
atgcagggta cacactggcc tccggcg                                           27


<210> 81
<211> 363
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region"

<400> 81
caggtccagc tggtacagtc tggatctgag gtgaagaagc ctggggccgc agtgaaggtc       60

tcctgcaagg cttctggtta catctttgcc aactttggtg tcagctgggt gcgacaggcc      120

cctggacaag ggcttgagtg gatgggatgg atcagcgctt acaatggtaa cacaaactat      180

gcacagaagt tccagggcag agtcatcatg accacagaca catccacgag cacagcctac      240

atggagctga ggagcctgag atctgacgac acggccgtgt attattgtgc gagagacccc      300

cccgcctacg ccgctacatt gatggacgtc tggggcaaag ggaccacggt cactgtctcc      360

tca                                                                    363


<210> 82
<211> 121
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region"

<400> 82
Gln Val Gln Leu Val Gln Ser Gly Ser Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ala Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Ile Phe Ala Asn Phe 
            20                  25                  30          


Gly Val Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Ser Ala Tyr Asn Gly Asn Thr Asn Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Ile Met Thr Thr Asp Thr Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Arg Ser Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Pro Pro Ala Tyr Ala Ala Thr Leu Met Asp Val Trp Gly 
            100                 105                 110         


Lys Gly Thr Thr Val Thr Val Ser Ser 
        115                 120     


<210> 83
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H1"

<400> 83
Tyr Ile Phe Ala Asn Phe Gly Val Ser 
1               5                   


<210> 84
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H1"

<400> 84
tacatctttg ccaactttgg tgtcagc                                           27


<210> 85
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H2"

<400> 85
Trp Ile Ser Ala Tyr Asn Gly Asn Thr Asn Tyr Ala Gln Lys Phe Gln 
1               5                   10                  15      


Gly 
    


<210> 86
<211> 51
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H2"

<400> 86
tggatcagcg cttacaatgg taacacaaac tatgcacaga agttccaggg c                51


<210> 87
<211> 14
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H3"

<400> 87
Ala Arg Asp Pro Pro Ala Tyr Ala Ala Thr Leu Met Asp Val 
1               5                   10                  


<210> 88
<211> 42
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H3"

<400> 88
gcgagagacc cccccgccta cgccgctaca ttgatggacg tc                          42


<210> 89
<211> 336
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region"

<400> 89
gaaattgtat tgacgcagtc tccactctcc ctgcccgtca cccttggaca gtcggcctcc       60

atctcctgca ggtctagtca aagcctcgaa cacagtgata caaacaccta cttgacttgg      120

tatcagcaga ggccaggcca atctccaagg cggctacttt ataaggtttc taaccgggac      180

tctggggtcc cagacagatt cagcggcagt gggtcaggca ctgatttcac actgaaaatc      240

agcagggtgg aggctgagga tgttggggtt tattactgca tgcaaggtac acactggcct      300

ccgacgttcg gccaagggac caaagtggat atcaaa                                336


<210> 90
<211> 112
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region"

<400> 90
Glu Ile Val Leu Thr Gln Ser Pro Leu Ser Leu Pro Val Thr Leu Gly 
1               5                   10                  15      


Gln Ser Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Glu His Ser 
            20                  25                  30          


Asp Thr Asn Thr Tyr Leu Thr Trp Tyr Gln Gln Arg Pro Gly Gln Ser 
        35                  40                  45              


Pro Arg Arg Leu Leu Tyr Lys Val Ser Asn Arg Asp Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Met Gln Gly 
                85                  90                  95      


Thr His Trp Pro Pro Thr Phe Gly Gln Gly Thr Lys Val Asp Ile Lys 
            100                 105                 110         


<210> 91
<211> 16
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L1"

<400> 91
Arg Ser Ser Gln Ser Leu Glu His Ser Asp Thr Asn Thr Tyr Leu Thr 
1               5                   10                  15      


<210> 92
<211> 48
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L1"

<400> 92
aggtctagtc aaagcctcga acacagtgat acaaacacct acttgact                    48


<210> 93
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L2"

<400> 93
Lys Val Ser Asn Arg Asp Ser 
1               5           


<210> 94
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L2"

<400> 94
aaggtttcta accgggactc t                                                 21


<210> 95
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L3"

<400> 95
Met Gln Gly Thr His Trp Pro Pro Thr 
1               5                   


<210> 96
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L3"

<400> 96
atgcaaggta cacactggcc tccgacg                                           27


<210> 97
<211> 375
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region"

<400> 97
caggtccagc ttgtacagtc tggggctgag gtgaagaagc ctgggtcctc ggtgagggtc       60

tcctgcaagg cctctggagg caccttcagg ggctatggtc tcagctgggt gcgacaggcc      120

cctggacagg gactcgagtg gatgggaggg atcacccatc tttttgggac agtcagctac      180

gctccgaagt tccagggcag actcacgatc accgcggacg catccacggg cacagcctac      240

atggagctga gcagcctgat atctgaggac acggccgtat atttttgtgc gagagatgct      300

tacgaagtgt ggaccggctc ttatctcccc ccttttgact actggggcca gggaacaatg      360

gtcaccgtct cttca                                                       375


<210> 98
<211> 125
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region"

<400> 98
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Arg Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Arg Gly Tyr 
            20                  25                  30          


Gly Leu Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Gly Ile Thr His Leu Phe Gly Thr Val Ser Tyr Ala Pro Lys Phe 
    50                  55                  60                  


Gln Gly Arg Leu Thr Ile Thr Ala Asp Ala Ser Thr Gly Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Ile Ser Glu Asp Thr Ala Val Tyr Phe Cys 
                85                  90                  95      


Ala Arg Asp Ala Tyr Glu Val Trp Thr Gly Ser Tyr Leu Pro Pro Phe 
            100                 105                 110         


Asp Tyr Trp Gly Gln Gly Thr Met Val Thr Val Ser Ser 
        115                 120                 125 


<210> 99
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H1"

<400> 99
Gly Thr Phe Arg Gly Tyr Gly Leu Ser 
1               5                   


<210> 100
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H1"

<400> 100
ggcaccttca ggggctatgg tctcagc                                           27


<210> 101
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H2"

<400> 101
Gly Ile Thr His Leu Phe Gly Thr Val Ser Tyr Ala Pro Lys Phe Gln 
1               5                   10                  15      


Gly 
    


<210> 102
<211> 51
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H2"

<400> 102
gggatcaccc atctttttgg gacagtcagc tacgctccga agttccaggg c                51


<210> 103
<211> 18
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H3"

<400> 103
Ala Arg Asp Ala Tyr Glu Val Trp Thr Gly Ser Tyr Leu Pro Pro Phe 
1               5                   10                  15      


Asp Tyr 
        


<210> 104
<211> 54
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H3"

<400> 104
gcgagagatg cttacgaagt gtggaccggc tcttatctcc ccccttttga ctac             54


<210> 105
<211> 324
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region"

<400> 105
gatattgtga tgactcagtc tccaggcacc ctgtctttgt ctcccgggga aagagtcacc       60

ctctcctgca gggccagtca gattattcca agcagttact tagcctggta ccagcagaaa      120

cctggccagg ctcccaggct cctcatctat ggtgcattca ccagggccac tgacatccca      180

gacaggttca gtggcagtgg gtctgggaca gacttcactc tcaccatcag cagactggag      240

cctgaagatt ttgcagtata ttattgtcag cagtatggta gttcatttct cactttcggc      300

ggagggacca aggtggaaat caaa                                             324


<210> 106
<211> 108
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region"

<400> 106
Asp Ile Val Met Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Val Thr Leu Ser Cys Arg Ala Ser Gln Ile Ile Pro Ser Ser 
            20                  25                  30          


Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu 
        35                  40                  45              


Ile Tyr Gly Ala Phe Thr Arg Ala Thr Asp Ile Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu 
65                  70                  75                  80  


Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Gly Ser Ser Phe 
                85                  90                  95      


Leu Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105             


<210> 107
<211> 12
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L1"

<400> 107
Arg Ala Ser Gln Ile Ile Pro Ser Ser Tyr Leu Ala 
1               5                   10          


<210> 108
<211> 36
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L1"

<400> 108
agggccagtc agattattcc aagcagttac ttagcc                                 36


<210> 109
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L2"

<400> 109
Gly Ala Phe Thr Arg Ala Thr 
1               5           


<210> 110
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L2"

<400> 110
ggtgcattca ccagggccac t                                                 21


<210> 111
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L3"

<400> 111
Gln Gln Tyr Gly Ser Ser Phe Leu Thr 
1               5                   


<210> 112
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L3"

<400> 112
cagcagtatg gtagttcatt tctcact                                           27


<210> 113
<211> 366
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region"

<400> 113
caggtccagc ttgtgcagtc tgggcctgag gtaaagaagc ctgggtcctc agtgacggtc       60

tcctgcaagg cttctggagg caccttcagc aactatggta ttgcttgggt gcgacaggcc      120

cctggacaag ggcttgagtg gatgggatca acaatcccta tccttggaac agcaagctac      180

agacagagct taaaggacag agtcacaatt accgcggacg cttccacgac cacagtctac      240

atggaaatga ctcgcctcag aactgaggac acggccgtct atttttgtgc gagagttccg      300

gagagtcttg tggcatcaaa cgcttatgct gtttggggcc aagggacggt ggtcactgtc      360

tcctca                                                                 366


<210> 114
<211> 122
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region"

<400> 114
Gln Val Gln Leu Val Gln Ser Gly Pro Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Thr Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Asn Tyr 
            20                  25                  30          


Gly Ile Ala Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Ser Thr Ile Pro Ile Leu Gly Thr Ala Ser Tyr Arg Gln Ser Leu 
    50                  55                  60                  


Lys Asp Arg Val Thr Ile Thr Ala Asp Ala Ser Thr Thr Thr Val Tyr 
65                  70                  75                  80  


Met Glu Met Thr Arg Leu Arg Thr Glu Asp Thr Ala Val Tyr Phe Cys 
                85                  90                  95      


Ala Arg Val Pro Glu Ser Leu Val Ala Ser Asn Ala Tyr Ala Val Trp 
            100                 105                 110         


Gly Gln Gly Thr Val Val Thr Val Ser Ser 
        115                 120         


<210> 115
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H1"

<400> 115
Gly Thr Phe Ser Asn Tyr Gly Ile Ala 
1               5                   


<210> 116
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H1"

<400> 116
ggcaccttca gcaactatgg tattgct                                           27


<210> 117
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H2"

<400> 117
Ser Thr Ile Pro Ile Leu Gly Thr Ala Ser Tyr Arg Gln Ser Leu Lys 
1               5                   10                  15      


Asp 
    


<210> 118
<211> 51
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H2"

<400> 118
tcaacaatcc ctatccttgg aacagcaagc tacagacaga gcttaaagga c                51


<210> 119
<211> 15
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H3"

<400> 119
Ala Arg Val Pro Glu Ser Leu Val Ala Ser Asn Ala Tyr Ala Val 
1               5                   10                  15  


<210> 120
<211> 45
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H3"

<400> 120
gcgagagttc cggagagtct tgtggcatca aacgcttatg ctgtt                       45


<210> 121
<211> 321
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region"

<400> 121
gacatccaga tgacccagtc tccatcttcc gtgtctgcat ctgtaggaga cagagtcacc       60

atcacttgtc gggcgagcca ggacattagc acctggttag cctggtatca gcagagacca      120

gggaaagccc caaaactcct gatctacact gcatccagtt tgcaaagtgg ggtcccatca      180

aggttcagcg gcagtggatc tgggacagag ttcactctca ccatcagcag cctgcagcct      240

gaagattttg caacttacta ttgtcaacag ggtaccagtt tcccattcac tttcggccct      300

gggaccaagc tggagatcaa a                                                321


<210> 122
<211> 107
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region"

<400> 122
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Val Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Ile Ser Thr Trp 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Arg Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Thr Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Gly Thr Ser Phe Pro Phe 
                85                  90                  95      


Thr Phe Gly Pro Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210> 123
<211> 11
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L1"

<400> 123
Arg Ala Ser Gln Asp Ile Ser Thr Trp Leu Ala 
1               5                   10      


<210> 124
<211> 33
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L1"

<400> 124
cgggcgagcc aggacattag cacctggtta gcc                                    33


<210> 125
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L2"

<400> 125
Thr Ala Ser Ser Leu Gln Ser 
1               5           


<210> 126
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L2"

<400> 126
actgcatcca gtttgcaaag t                                                 21


<210> 127
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L3"

<400> 127
Gln Gln Gly Thr Ser Phe Pro Phe Thr 
1               5                   


<210> 128
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L3"

<400> 128
caacagggta ccagtttccc attcact                                           27


<210> 129
<211> 372
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region"

<400> 129
gaggtgcagc tggtggagtc tggggctgag atgaagaagc ctggggcctc agtgaaggtt       60

tcctgcaagg cttctggata caccttcact aactatgcta tacattgggt gcgccaggcc      120

cccggccaaa gccttgagtg gatgggatgg atcaacgctg gcaatggtaa cacacaatat      180

tcacagaagt tccagggcag agtcaccttt accagggaca catccgcgag cacggtctac      240

atggacctga gcagcctgag atctgaagac acggctgtct attactgtgc gagaggccaa      300

attgttgtta taccacgtgc taatttctgg ttcgacccct ggggccaggg aaccctggtc      360

accgtctcct ca                                                          372


<210> 130
<211> 124
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region"

<400> 130
Glu Val Gln Leu Val Glu Ser Gly Ala Glu Met Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asn Tyr 
            20                  25                  30          


Ala Ile His Trp Val Arg Gln Ala Pro Gly Gln Ser Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Asn Ala Gly Asn Gly Asn Thr Gln Tyr Ser Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Phe Thr Arg Asp Thr Ser Ala Ser Thr Val Tyr 
65                  70                  75                  80  


Met Asp Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Gln Ile Val Val Ile Pro Arg Ala Asn Phe Trp Phe Asp 
            100                 105                 110         


Pro Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 


<210> 131
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H1"

<400> 131
Tyr Thr Phe Thr Asn Tyr Ala Ile His 
1               5                   


<210> 132
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H1"

<400> 132
tacaccttca ctaactatgc tatacat                                           27


<210> 133
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H2"

<400> 133
Trp Ile Asn Ala Gly Asn Gly Asn Thr Gln Tyr Ser Gln Lys Phe Gln 
1               5                   10                  15      


Gly 
    


<210> 134
<211> 51
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H2"

<400> 134
tggatcaacg ctggcaatgg taacacacaa tattcacaga agttccaggg c                51


<210> 135
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H3"

<400> 135
Ala Arg Gly Gln Ile Val Val Ile Pro Arg Ala Asn Phe Trp Phe Asp 
1               5                   10                  15      


Pro 
    


<210> 136
<211> 51
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H3"

<400> 136
gcgagaggcc aaattgttgt tataccacgt gctaatttct ggttcgaccc c                51


<210> 137
<211> 336
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region"

<400> 137
gatattgtgc tgacccagtc tccactctcc ctgcccgtca cccctggaga gccggcctcc       60

atctcctgca ggtctagtca gagcctcctg catagtcatg gatacaacta tttggattgg      120

tacttgcaga agccagggca gtctccacag ctcctgatct atttgggttc taatcgggcc      180

tccggggtcc ctgacaggtt cagtggcagt ggatcaggca cagattttac actgaaaatc      240

agcagagtgg aggctgagga tgttggggtt tattactgca tgcaaactct acaaactccg      300

atcaccttcg gccaagggac acgaatggag attaaa                                336


<210> 138
<211> 112
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region"

<400> 138
Asp Ile Val Leu Thr Gln Ser Pro Leu Ser Leu Pro Val Thr Pro Gly 
1               5                   10                  15      


Glu Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Leu His Ser 
            20                  25                  30          


His Gly Tyr Asn Tyr Leu Asp Trp Tyr Leu Gln Lys Pro Gly Gln Ser 
        35                  40                  45              


Pro Gln Leu Leu Ile Tyr Leu Gly Ser Asn Arg Ala Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Met Gln Thr 
                85                  90                  95      


Leu Gln Thr Pro Ile Thr Phe Gly Gln Gly Thr Arg Met Glu Ile Lys 
            100                 105                 110         


<210> 139
<211> 16
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L1"

<400> 139
Arg Ser Ser Gln Ser Leu Leu His Ser His Gly Tyr Asn Tyr Leu Asp 
1               5                   10                  15      


<210> 140
<211> 48
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L1"

<400> 140
aggtctagtc agagcctcct gcatagtcat ggatacaact atttggat                    48


<210> 141
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L2"

<400> 141
Leu Gly Ser Asn Arg Ala Ser 
1               5           


<210> 142
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L2"

<400> 142
ttgggttcta atcgggcctc c                                                 21


<210> 143
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L3"

<400> 143
Met Gln Thr Leu Gln Thr Pro Ile Thr 
1               5                   


<210> 144
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L3"

<400> 144
atgcaaactc tacaaactcc gatcacc                                           27


<210> 145
<211> 378
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region"

<400> 145
gaggtgcagc tgcaggagtc gggcccagga ctggtgaagc ctttacagac cctgtccgtc       60

acctgcagtg tctctggtgg ctccatcagc agtggtgata actactggag ctggatccgc      120

cagcgcccag ggaagggcct ggagtggatt gggtacatct attacagtgg gaccacctac      180

tacaatccgt ccctcaagag tcgagttacc atatcagcag acaggtctaa gaatcagttt      240

tctctgaaga tgaattctct gagtgccgcg gacacggccg tgtattactg tgcgagagat      300

ggcggatatg atcacatctg ggggactcat cgttatttcg ccctctgggg ccagggaacc      360

ctggtcaccg tctcctca                                                    378


<210> 146
<211> 126
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region"

<400> 146
Glu Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Leu Gln 
1               5                   10                  15      


Thr Leu Ser Val Thr Cys Ser Val Ser Gly Gly Ser Ile Ser Ser Gly 
            20                  25                  30          


Asp Asn Tyr Trp Ser Trp Ile Arg Gln Arg Pro Gly Lys Gly Leu Glu 
        35                  40                  45              


Trp Ile Gly Tyr Ile Tyr Tyr Ser Gly Thr Thr Tyr Tyr Asn Pro Ser 
    50                  55                  60                  


Leu Lys Ser Arg Val Thr Ile Ser Ala Asp Arg Ser Lys Asn Gln Phe 
65                  70                  75                  80  


Ser Leu Lys Met Asn Ser Leu Ser Ala Ala Asp Thr Ala Val Tyr Tyr 
                85                  90                  95      


Cys Ala Arg Asp Gly Gly Tyr Asp His Ile Trp Gly Thr His Arg Tyr 
            100                 105                 110         


Phe Ala Leu Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125     


<210> 147
<211> 11
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H1"

<400> 147
Gly Ser Ile Ser Ser Gly Asp Asn Tyr Trp Ser 
1               5                   10      


<210> 148
<211> 33
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H1"

<400> 148
ggctccatca gcagtggtga taactactgg agc                                    33


<210> 149
<211> 16
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H2"

<400> 149
Tyr Ile Tyr Tyr Ser Gly Thr Thr Tyr Tyr Asn Pro Ser Leu Lys Ser 
1               5                   10                  15      


<210> 150
<211> 48
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H2"

<400> 150
tacatctatt acagtgggac cacctactac aatccgtccc tcaagagt                    48


<210> 151
<211> 18
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H3"

<400> 151
Ala Arg Asp Gly Gly Tyr Asp His Ile Trp Gly Thr His Arg Tyr Phe 
1               5                   10                  15      


Ala Leu 
        


<210> 152
<211> 54
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H3"

<400> 152
gcgagagatg gcggatatga tcacatctgg gggactcatc gttatttcgc cctc             54


<210> 153
<211> 324
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region"

<400> 153
gaaacgacac tcacgcagtc tccaggcacc ctgtctttgt ctccagggga aagagccacc       60

ctctcctgca gggccagtca gagtgttaac agcgactact tggcctggta ccagcagaaa      120

cttggccagg ctcccaggct cctcatttat ggtgtatcca acagggccac tggcatccca      180

gacaggttta ctgggagtgg gtctgggaca gacttcactc tcaccatcag cagactggag      240

cctgaagatt ttgcagtcta tcactgtcag cagtatggta cctcaccgtg gacgttcggc      300

caagggacca aggtggagat caaa                                             324


<210> 154
<211> 108
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region"

<400> 154
Glu Thr Thr Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Asn Ser Asp 
            20                  25                  30          


Tyr Leu Ala Trp Tyr Gln Gln Lys Leu Gly Gln Ala Pro Arg Leu Leu 
        35                  40                  45              


Ile Tyr Gly Val Ser Asn Arg Ala Thr Gly Ile Pro Asp Arg Phe Thr 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu 
65                  70                  75                  80  


Pro Glu Asp Phe Ala Val Tyr His Cys Gln Gln Tyr Gly Thr Ser Pro 
                85                  90                  95      


Trp Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105             


<210> 155
<211> 12
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L1"

<400> 155
Arg Ala Ser Gln Ser Val Asn Ser Asp Tyr Leu Ala 
1               5                   10          


<210> 156
<211> 36
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L1"

<400> 156
agggccagtc agagtgttaa cagcgactac ttggcc                                 36


<210> 157
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L2"

<400> 157
Gly Val Ser Asn Arg Ala Thr 
1               5           


<210> 158
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L2"

<400> 158
ggtgtatcca acagggccac t                                                 21


<210> 159
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L3"

<400> 159
Gln Gln Tyr Gly Thr Ser Pro Trp Thr 
1               5                   


<210> 160
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L3"

<400> 160
cagcagtatg gtacctcacc gtggacg                                           27


<210> 161
<211> 375
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region"

<400> 161
caggtccagc ttgtacagtc tggggctgag gtgaagaggc ctgggtcctc ggtgaaagtc       60

tcctgtaagg cctctggagg caccttcagt agttatgctc tctcctgggt acggcaggcc      120

cctggacaag gacttgagtg gatagggggg atcatcccta tgcatcgtgt aacaaattac      180

gcacagaaat ttcggggcag agtcacaatt tccgcggaca catccacgag tacggcctac      240

ttggaggtga acagcctgag agttgaggac acggccatgt attactgtgc gagagtgttt      300

ttcggaactt gtggcggtgc ttcgtgcttc ccctctgacc tctggggcca gggaaccctg      360

gtcactgtct cctca                                                       375


<210> 162
<211> 125
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region"

<400> 162
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Arg Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Leu Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Gly Ile Ile Pro Met His Arg Val Thr Asn Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Arg Gly Arg Val Thr Ile Ser Ala Asp Thr Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Leu Glu Val Asn Ser Leu Arg Val Glu Asp Thr Ala Met Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Val Phe Phe Gly Thr Cys Gly Gly Ala Ser Cys Phe Pro Ser 
            100                 105                 110         


Asp Leu Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125 


<210> 163
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H1"

<400> 163
Gly Thr Phe Ser Ser Tyr Ala Leu Ser 
1               5                   


<210> 164
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H1"

<400> 164
ggcaccttca gtagttatgc tctctcc                                           27


<210> 165
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H2"

<400> 165
Gly Ile Ile Pro Met His Arg Val Thr Asn Tyr Ala Gln Lys Phe Arg 
1               5                   10                  15      


Gly 
    


<210> 166
<211> 51
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H2"

<400> 166
gggatcatcc ctatgcatcg tgtaacaaat tacgcacaga aatttcgggg c                51


<210> 167
<211> 18
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H3"

<400> 167
Ala Arg Val Phe Phe Gly Thr Cys Gly Gly Ala Ser Cys Phe Pro Ser 
1               5                   10                  15      


Asp Leu 
        


<210> 168
<211> 54
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H3"

<400> 168
gcgagagtgt ttttcggaac ttgtggcggt gcttcgtgct tcccctctga cctc             54


<210> 169
<211> 321
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region"

<400> 169
gaaattgtgt tgacacagtc tccatccttc gtgtctgctt ctgtcggaga cggggtcacc       60

atcacttgcc gggccagtca ggccattagc agttatttag cctggtatca gcaaaaacca      120

gggcaagccc ctaaactcct gatctatgct gcatccactt tgcaaggtgg tgtcccatca      180

aggttcagcg gcagtggatc tgggacacat ttcactctca ccatcagcag cctgcagcct      240

gaagattttg caacttatta ctgtcagcaa cttcatagtg attttcagac tttcggccct      300

gggaccaagg tggaaatcaa a                                                321


<210> 170
<211> 107
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region"

<400> 170
Glu Ile Val Leu Thr Gln Ser Pro Ser Phe Val Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Gly Val Thr Ile Thr Cys Arg Ala Ser Gln Ala Ile Ser Ser Tyr 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Thr Leu Gln Gly Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr His Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Leu His Ser Asp Phe Gln 
                85                  90                  95      


Thr Phe Gly Pro Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210> 171
<211> 11
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L1"

<400> 171
Arg Ala Ser Gln Ala Ile Ser Ser Tyr Leu Ala 
1               5                   10      


<210> 172
<211> 33
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L1"

<400> 172
cgggccagtc aggccattag cagttattta gcc                                    33


<210> 173
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L2"

<400> 173
Ala Ala Ser Thr Leu Gln Gly 
1               5           


<210> 174
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L2"

<400> 174
gctgcatcca ctttgcaagg t                                                 21


<210> 175
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L3"

<400> 175
Gln Gln Leu His Ser Asp Phe Gln Thr 
1               5                   


<210> 176
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L3"

<400> 176
cagcaacttc atagtgattt tcagact                                           27


<210> 177
<211> 360
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region"

<400> 177
caggtgcagc tggtggaatc tgggggaggc gtggtccagc ctgggaggtc cctgagactc       60

tcctgtgtag cgtctggatt cagcttcagt atgcatggca tgcactgggt ccgccaggct      120

ccaggcaagg ggctggagtg ggtgacagct atatggtatg atggaagtaa taaatattat      180

gcagactccg tgaagggccg attcacgatc tccagagaca attctaggaa cacgctgtat      240

ctgcaaatga acagcctgag agccgaggac acggctgtgt attactgtgc gagagatcat      300

gcctcaactc catactacat ggacgtctgg ggcaaaggga ccacggtcac cgtctcctca      360


<210> 178
<211> 120
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region"

<400> 178
Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Val Ala Ser Gly Phe Ser Phe Ser Met His 
            20                  25                  30          


Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Thr Ala Ile Trp Tyr Asp Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Arg Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp His Ala Ser Thr Pro Tyr Tyr Met Asp Val Trp Gly Lys 
            100                 105                 110         


Gly Thr Thr Val Thr Val Ser Ser 
        115                 120 


<210> 179
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H1"

<400> 179
Phe Ser Phe Ser Met His Gly Met His 
1               5                   


<210> 180
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H1"

<400> 180
ttcagcttca gtatgcatgg catgcac                                           27


<210> 181
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H2"

<400> 181
Ala Ile Trp Tyr Asp Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210> 182
<211> 51
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H2"

<400> 182
gctatatggt atgatggaag taataaatat tatgcagact ccgtgaaggg c                51


<210> 183
<211> 13
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H3"

<400> 183
Ala Arg Asp His Ala Ser Thr Pro Tyr Tyr Met Asp Val 
1               5                   10              


<210> 184
<211> 39
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H3"

<400> 184
gcgagagatc atgcctcaac tccatactac atggacgtc                              39


<210> 185
<211> 324
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region"

<400> 185
gaaacgacac tcacgcagtc tccaggcacc ctgtctttgt ctccagggga aagcgccacc       60

ctctcctgca ggaccagtca gaggattagc agcacctact tagcctggta ccggcagaaa      120

cctggccagg ctcccaggct cctcatgtat ggtgcatcca gcagggccac tggcatcccg      180

gacaggttca gtggcagtgg gtctgggaca gacttcactc tcaccatcag cagtctggag      240

cctgaagatt ttgcactata ttactgtcag cagtatggta gctttccgtg gacgttcggc      300

caagggacca agctggagat caaa                                             324


<210> 186
<211> 108
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region"

<400> 186
Glu Thr Thr Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Ser Ala Thr Leu Ser Cys Arg Thr Ser Gln Arg Ile Ser Ser Thr 
            20                  25                  30          


Tyr Leu Ala Trp Tyr Arg Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu 
        35                  40                  45              


Met Tyr Gly Ala Ser Ser Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu 
65                  70                  75                  80  


Pro Glu Asp Phe Ala Leu Tyr Tyr Cys Gln Gln Tyr Gly Ser Phe Pro 
                85                  90                  95      


Trp Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105             


<210> 187
<211> 12
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L1"

<400> 187
Arg Thr Ser Gln Arg Ile Ser Ser Thr Tyr Leu Ala 
1               5                   10          


<210> 188
<211> 36
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L1"

<400> 188
aggaccagtc agaggattag cagcacctac ttagcc                                 36


<210> 189
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L2"

<400> 189
Gly Ala Ser Ser Arg Ala Thr 
1               5           


<210> 190
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L2"

<400> 190
ggtgcatcca gcagggccac t                                                 21


<210> 191
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L3"

<400> 191
Gln Gln Tyr Gly Ser Phe Pro Trp Thr 
1               5                   


<210> 192
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L3"

<400> 192
cagcagtatg gtagctttcc gtggacg                                           27


<210> 193
<211> 378
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region"

<400> 193
caggtgcagc tacagcagtg gggcgcagga ctgtggaagc cttcgcagac cctgtccctc       60

acctgcgctg tccatggtgg atccctcagt ggctactctt ggagttggat ccgccagtcc      120

ccagggaggg gactggagtg gatcggcgaa gtcaatcgta ggggaaccac caactacaac      180

ccctccctca agggtcgagt ctccatatcc tgggacacgt ccaagaacca ggtctccctg      240

tccctgaggt ctgtgaccgc cgcggacacg gctacatatt actgtgcggg gaccaatgtt      300

ggattcgtta atacccataa cgactactac ttcggtatgg acgtctgggg ccaagggacc      360

acggtcaccg tctcctca                                                    378


<210> 194
<211> 126
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region"

<400> 194
Gln Val Gln Leu Gln Gln Trp Gly Ala Gly Leu Trp Lys Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Ala Val His Gly Gly Ser Leu Ser Gly Tyr 
            20                  25                  30          


Ser Trp Ser Trp Ile Arg Gln Ser Pro Gly Arg Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Glu Val Asn Arg Arg Gly Thr Thr Asn Tyr Asn Pro Ser Leu Lys 
    50                  55                  60                  


Gly Arg Val Ser Ile Ser Trp Asp Thr Ser Lys Asn Gln Val Ser Leu 
65                  70                  75                  80  


Ser Leu Arg Ser Val Thr Ala Ala Asp Thr Ala Thr Tyr Tyr Cys Ala 
                85                  90                  95      


Gly Thr Asn Val Gly Phe Val Asn Thr His Asn Asp Tyr Tyr Phe Gly 
            100                 105                 110         


Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120                 125     


<210> 195
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H1"

<400> 195
Gly Ser Leu Ser Gly Tyr Ser Trp Ser 
1               5                   


<210> 196
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H1"

<400> 196
ggatccctca gtggctactc ttggagt                                           27


<210> 197
<211> 16
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H2"

<400> 197
Glu Val Asn Arg Arg Gly Thr Thr Asn Tyr Asn Pro Ser Leu Lys Gly 
1               5                   10                  15      


<210> 198
<211> 48
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H2"

<400> 198
gaagtcaatc gtaggggaac caccaactac aacccctccc tcaagggt                    48


<210> 199
<211> 20
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H3"

<400> 199
Ala Gly Thr Asn Val Gly Phe Val Asn Thr His Asn Asp Tyr Tyr Phe 
1               5                   10                  15      


Gly Met Asp Val 
            20  


<210> 200
<211> 60
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H3"

<400> 200
gcggggacca atgttggatt cgttaatacc cataacgact actacttcgg tatggacgtc       60


<210> 201
<211> 321
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region"

<400> 201
gatattgtga tgactcagtc tccatcctcc ctgtctgcat cggttggaga cagagtcacc       60

atcacttgcc gggcaagtca gagcataagc aattatgtaa attggtatca gaaaaaaaca      120

ggtcaagtcc ctaaactcct gatctatggt gcatccaatt tggaaagtgg ggtcccatca      180

aggttcagtg gcggtggatc tgggacagat ttcactctca ccatcagcag tctgcaacct      240

gaagattttg caacttatta ctgtcaacag agttacagtg tcccgctcac tttcggcgga      300

gggaccaagg tggaaatcaa a                                                321


<210> 202
<211> 107
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region"

<400> 202
Asp Ile Val Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Asn Tyr 
            20                  25                  30          


Val Asn Trp Tyr Gln Lys Lys Thr Gly Gln Val Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Gly Ala Ser Asn Leu Glu Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Gly Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Tyr Ser Val Pro Leu 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210> 203
<211> 11
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L1"

<400> 203
Arg Ala Ser Gln Ser Ile Ser Asn Tyr Val Asn 
1               5                   10      


<210> 204
<211> 33
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L1"

<400> 204
cgggcaagtc agagcataag caattatgta aat                                    33


<210> 205
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L2"

<400> 205
Gly Ala Ser Asn Leu Glu Ser 
1               5           


<210> 206
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L2"

<400> 206
ggtgcatcca atttggaaag t                                                 21


<210> 207
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L3"

<400> 207
Gln Gln Ser Tyr Ser Val Pro Leu Thr 
1               5                   


<210> 208
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L3"

<400> 208
caacagagtt acagtgtccc gctcact                                           27


<210> 209
<211> 375
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region"

<400> 209
caggtccagc ttgtacagtc tggggctgag gtgaagaggc ctggatcctc ggtgaaggtc       60

tcctgcaagg cgtctggagg caccttccgc ggctaccata tcagctggct gcgccaggcc      120

cctggacagg gcctcgagtg gctgggaggg atcacccatt tgtttgggac agttagttac      180

gctccgaagt tccagggcag agtcaccatc accgcggacg catccacggg cacactttac      240

atggtgttga acagcctgaa acctgaggac acggccattt attattgtgc gagagatgct      300

tacgaggtgt ggactggttc ttatctcccc ccttttgact actggggcca gggaaccctg      360

gtcaccgtct cctca                                                       375


<210> 210
<211> 125
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region"

<400> 210
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Arg Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Arg Gly Tyr 
            20                  25                  30          


His Ile Ser Trp Leu Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Leu 
        35                  40                  45              


Gly Gly Ile Thr His Leu Phe Gly Thr Val Ser Tyr Ala Pro Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Ala Asp Ala Ser Thr Gly Thr Leu Tyr 
65                  70                  75                  80  


Met Val Leu Asn Ser Leu Lys Pro Glu Asp Thr Ala Ile Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Ala Tyr Glu Val Trp Thr Gly Ser Tyr Leu Pro Pro Phe 
            100                 105                 110         


Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125 


<210> 211
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H1"

<400> 211
Gly Thr Phe Arg Gly Tyr His Ile Ser 
1               5                   


<210> 212
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H1"

<400> 212
ggcaccttcc gcggctacca tatcagc                                           27


<210> 213
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H2"

<400> 213
Gly Ile Thr His Leu Phe Gly Thr Val Ser Tyr Ala Pro Lys Phe Gln 
1               5                   10                  15      


Gly 
    


<210> 214
<211> 51
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H2"

<400> 214
gggatcaccc atttgtttgg gacagttagt tacgctccga agttccaggg c                51


<210> 215
<211> 18
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H3"

<400> 215
Ala Arg Asp Ala Tyr Glu Val Trp Thr Gly Ser Tyr Leu Pro Pro Phe 
1               5                   10                  15      


Asp Tyr 
        


<210> 216
<211> 54
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H3"

<400> 216
gcgagagatg cttacgaggt gtggactggt tcttatctcc ccccttttga ctac             54


<210> 217
<211> 324
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region"

<400> 217
gaaacgacac tcacgcagtc tccaggcacc ctgtctttgt ctcccgggga aagagccacc       60

ctctcttgca gggccagtca gactgttaca agcaactact tagcctggta ccagcagaaa      120

cctggccagg ctcccaggct cctcatctat gatgcactca ccagggccac tggcatccca      180

gacaggttca gtggcagtgg gtctgggaca gacttcactc tcaccatcag cagactggag      240

cctgaagatt ttgcacttta ttattgtcag cagtatggta gttcattcct cactttcggc      300

ggagggacca aagtggatat caaa                                             324


<210> 218
<211> 108
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region"

<400> 218
Glu Thr Thr Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Thr Val Thr Ser Asn 
            20                  25                  30          


Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu 
        35                  40                  45              


Ile Tyr Asp Ala Leu Thr Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu 
65                  70                  75                  80  


Pro Glu Asp Phe Ala Leu Tyr Tyr Cys Gln Gln Tyr Gly Ser Ser Phe 
                85                  90                  95      


Leu Thr Phe Gly Gly Gly Thr Lys Val Asp Ile Lys 
            100                 105             


<210> 219
<211> 12
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L1"

<400> 219
Arg Ala Ser Gln Thr Val Thr Ser Asn Tyr Leu Ala 
1               5                   10          


<210> 220
<211> 36
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L1"

<400> 220
agggccagtc agactgttac aagcaactac ttagcc                                 36


<210> 221
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L2"

<400> 221
Asp Ala Leu Thr Arg Ala Thr 
1               5           


<210> 222
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L2"

<400> 222
gatgcactca ccagggccac t                                                 21


<210> 223
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L3"

<400> 223
Gln Gln Tyr Gly Ser Ser Phe Leu Thr 
1               5                   


<210> 224
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L3"

<400> 224
cagcagtatg gtagttcatt cctcact                                           27


<210> 225
<211> 375
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region"

<400> 225
caggtgcagc tgcaggagtc cggggctgag gtgaagaagc ctgggtcctc ggtgaaggtc       60

tcctgcaagg cttctggagg cgccttcagc agctatgcta tcagctgggt gcgacaggcc      120

cctggacagg gcctcgagtg gctgggaggg atcacccatt tgtttgggac agttagttac      180

gctccgaagt tccagggcag agtcaccatc accgcggacg catccacggg cacactttac      240

atggtgttga acagcctgaa acctgaggac acggccattt attattgtgc gagagatgct      300

tacgaggtgt ggactggttc ttatctcccc ccttttgact actggggcca gggaaccctg      360

gtcaccgtct cctca                                                       375


<210> 226
<211> 125
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region"

<400> 226
Gln Val Gln Leu Gln Glu Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Ala Phe Ser Ser Tyr 
            20                  25                  30          


Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Leu 
        35                  40                  45              


Gly Gly Ile Thr His Leu Phe Gly Thr Val Ser Tyr Ala Pro Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Ala Asp Ala Ser Thr Gly Thr Leu Tyr 
65                  70                  75                  80  


Met Val Leu Asn Ser Leu Lys Pro Glu Asp Thr Ala Ile Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Ala Tyr Glu Val Trp Thr Gly Ser Tyr Leu Pro Pro Phe 
            100                 105                 110         


Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125 


<210> 227
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H1"

<400> 227
Gly Ala Phe Ser Ser Tyr Ala Ile Ser 
1               5                   


<210> 228
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H1"

<400> 228
ggcgccttca gcagctatgc tatcagc                                           27


<210> 229
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H2"

<400> 229
Gly Ile Thr His Leu Phe Gly Thr Val Ser Tyr Ala Pro Lys Phe Gln 
1               5                   10                  15      


Gly 
    


<210> 230
<211> 51
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H2"

<400> 230
gggatcaccc atttgtttgg gacagttagt tacgctccga agttccaggg c                51


<210> 231
<211> 18
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H3"

<400> 231
Ala Arg Asp Ala Tyr Glu Val Trp Thr Gly Ser Tyr Leu Pro Pro Phe 
1               5                   10                  15      


Asp Tyr 
        


<210> 232
<211> 54
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H3"

<400> 232
gcgagagatg cttacgaggt gtggactggt tcttatctcc ccccttttga ctac             54


<210> 233
<211> 324
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region"

<400> 233
gaaattgtat tgacacagtc tccaggcacc ctgtctttgt ctcccgggga aagagccacc       60

ctctcttgca gggccagtca gactgttaca agcaactact tagcctggta ccagcagaaa      120

cctggccagg ctcccaggct cctcatctat gatgcactca ccagggccac tggcatccca      180

gacaggttca gtggcagtgg gtctgggaca gacttcactc tcaccatcag cagactggag      240

cctgaagatt ttgcacttta ttattgtcag cagtatggta gttcattcct cactttcggc      300

ggagggacca agctggagat caaa                                             324


<210> 234
<211> 108
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region"

<400> 234
Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Thr Val Thr Ser Asn 
            20                  25                  30          


Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu 
        35                  40                  45              


Ile Tyr Asp Ala Leu Thr Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu 
65                  70                  75                  80  


Pro Glu Asp Phe Ala Leu Tyr Tyr Cys Gln Gln Tyr Gly Ser Ser Phe 
                85                  90                  95      


Leu Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105             


<210> 235
<211> 12
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L1"

<400> 235
Arg Ala Ser Gln Thr Val Thr Ser Asn Tyr Leu Ala 
1               5                   10          


<210> 236
<211> 36
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L1"

<400> 236
agggccagtc agactgttac aagcaactac ttagcc                                 36


<210> 237
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L2"

<400> 237
Asp Ala Leu Thr Arg Ala Thr 
1               5           


<210> 238
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L2"

<400> 238
gatgcactca ccagggccac t                                                 21


<210> 239
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L3"

<400> 239
Gln Gln Tyr Gly Ser Ser Phe Leu Thr 
1               5                   


<210> 240
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L3"

<400> 240
cagcagtatg gtagttcatt cctcact                                           27


<210> 241
<211> 366
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region"

<400> 241
caggtccagc tggtacagtc tggagctgag gtgaaggagc ctggggcctc agtgagggtc       60

tcctgcaagg cttctggtta cacctttacc agctatggta tcagctgggt gcgacaggcc      120

cctggacaag ggcttgagtg gatgggatgg atcagcgctt acaatggtaa cacaaactat      180

gcacagaagt tccagggcag agtcaccgtg accacagaca catccacgag cgcagcctac      240

atggagctga ggagcctgag atctgacgac acggccattt attactgtgc gagagattca      300

ttttcactga ctggtgctgg atttcctgac tactggggcc agggaaccct ggtcaccgtc      360

tcctca                                                                 366


<210> 242
<211> 122
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region"

<400> 242
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Glu Pro Gly Ala 
1               5                   10                  15      


Ser Val Arg Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Gly Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Ser Ala Tyr Asn Gly Asn Thr Asn Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Val Thr Thr Asp Thr Ser Thr Ser Ala Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Arg Ser Leu Arg Ser Asp Asp Thr Ala Ile Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Ser Phe Ser Leu Thr Gly Ala Gly Phe Pro Asp Tyr Trp 
            100                 105                 110         


Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120         


<210> 243
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H1"

<400> 243
Tyr Thr Phe Thr Ser Tyr Gly Ile Ser 
1               5                   


<210> 244
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H1"

<400> 244
tacaccttta ccagctatgg tatcagc                                           27


<210> 245
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H2"

<400> 245
Trp Ile Ser Ala Tyr Asn Gly Asn Thr Asn Tyr Ala Gln Lys Phe Gln 
1               5                   10                  15      


Gly 
    


<210> 246
<211> 51
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H2"

<400> 246
tggatcagcg cttacaatgg taacacaaac tatgcacaga agttccaggg c                51


<210> 247
<211> 15
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H3"

<400> 247
Ala Arg Asp Ser Phe Ser Leu Thr Gly Ala Gly Phe Pro Asp Tyr 
1               5                   10                  15  


<210> 248
<211> 45
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H3"

<400> 248
gcgagagatt cattttcact gactggtgct ggatttcctg actac                       45


<210> 249
<211> 336
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region"

<400> 249
gaaattgtaa tgacgcagtc tccactctcc ctgcccgtca cccttggaca gccggcctcc       60

atctcctgca ggtctagtca aagcctcgta tacagtgatg gaaacaccta cttgaattgg      120

tttcagcaga ggccaggcca atctccaagg cgcctaattt ataaggtttc taaccgggac      180

tctggggtcc cagacagatt cagcggcagt gggtcagaca ctgatttcac actgaaaatc      240

agcagggtgg aggctgagga tgttggggtt tattactgca tgcaagctac acagtggcct      300

cgcacgttcg gccaagggac caaggtggaa atcaaa                                336


<210> 250
<211> 112
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region"

<400> 250
Glu Ile Val Met Thr Gln Ser Pro Leu Ser Leu Pro Val Thr Leu Gly 
1               5                   10                  15      


Gln Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Val Tyr Ser 
            20                  25                  30          


Asp Gly Asn Thr Tyr Leu Asn Trp Phe Gln Gln Arg Pro Gly Gln Ser 
        35                  40                  45              


Pro Arg Arg Leu Ile Tyr Lys Val Ser Asn Arg Asp Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Asp Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Met Gln Ala 
                85                  90                  95      


Thr Gln Trp Pro Arg Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105                 110         


<210> 251
<211> 16
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L1"

<400> 251
Arg Ser Ser Gln Ser Leu Val Tyr Ser Asp Gly Asn Thr Tyr Leu Asn 
1               5                   10                  15      


<210> 252
<211> 48
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L1"

<400> 252
aggtctagtc aaagcctcgt atacagtgat ggaaacacct acttgaat                    48


<210> 253
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L2"

<400> 253
Lys Val Ser Asn Arg Asp Ser 
1               5           


<210> 254
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L2"

<400> 254
aaggtttcta accgggactc t                                                 21


<210> 255
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L3"

<400> 255
Met Gln Ala Thr Gln Trp Pro Arg Thr 
1               5                   


<210> 256
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L3"

<400> 256
atgcaagcta cacagtggcc tcgcacg                                           27


<210> 257
<211> 360
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region"

<400> 257
gaggtgcagc tgttggagtc tgggggaggc ctggtcaagc ctggggggtc cctgagactc       60

tcctgtgtag cctctggatt caccttcagt agctataaca tcaactgggt ccgccaggct      120

ccagggaagg gactggagtg ggtctcatcc attagtggtg gtagtaatta catagactac      180

gcagactcag tgaagggccg attcaccatc tccagagaca acgccaagaa ctcactgtat      240

ttgcaaatga acaacctgcg agccgaagac acggctgtgt attactgtgc gagacttggc      300

tatggtggta acccggagct tgactattgg ggccagggaa ccctggtcac tgtctcctca      360


<210> 258
<211> 120
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region"

<400> 258
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Val Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Asn Ile Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ser Ile Ser Gly Gly Ser Asn Tyr Ile Asp Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Asn Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Leu Gly Tyr Gly Gly Asn Pro Glu Leu Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser 
        115                 120 


<210> 259
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H1"

<400> 259
Phe Thr Phe Ser Ser Tyr Asn Ile Asn 
1               5                   


<210> 260
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H1"

<400> 260
ttcaccttca gtagctataa catcaac                                           27


<210> 261
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H2"

<400> 261
Ser Ile Ser Gly Gly Ser Asn Tyr Ile Asp Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210> 262
<211> 51
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H2"

<400> 262
tccattagtg gtggtagtaa ttacatagac tacgcagact cagtgaaggg c                51


<210> 263
<211> 13
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H3"

<400> 263
Ala Arg Leu Gly Tyr Gly Gly Asn Pro Glu Leu Asp Tyr 
1               5                   10              


<210> 264
<211> 39
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H3"

<400> 264
gcgagacttg gctatggtgg taacccggag cttgactat                              39


<210> 265
<211> 336
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region"

<400> 265
cagtctgtgc tgacgcagcc gccctcagtg tctggggccc caggacagag ggtcaccatc       60

tcctgcaccg ggagcagctc caacatcggg gcaggttatg atgtacactg gtaccagcaa      120

cgtccaggaa cagcccccaa actcctcatc tatgctaata acaatcggcc ctcaggggtc      180

cctgaccgat tctctggctc caagtctggc acctcagcct ccctggccat cactgggctc      240

caggctgagg atgaggctga ttattactgc cagtcctatg acctcagtct gagtagttcg      300

agggtattcg gcggagggac caagctgacc gtcctc                                336


<210> 266
<211> 112
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region"

<400> 266
Gln Ser Val Leu Thr Gln Pro Pro Ser Val Ser Gly Ala Pro Gly Gln 
1               5                   10                  15      


Arg Val Thr Ile Ser Cys Thr Gly Ser Ser Ser Asn Ile Gly Ala Gly 
            20                  25                  30          


Tyr Asp Val His Trp Tyr Gln Gln Arg Pro Gly Thr Ala Pro Lys Leu 
        35                  40                  45              


Leu Ile Tyr Ala Asn Asn Asn Arg Pro Ser Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Thr Gly Leu 
65                  70                  75                  80  


Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Gln Ser Tyr Asp Leu Ser 
                85                  90                  95      


Leu Ser Ser Ser Arg Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 110         


<210> 267
<211> 14
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L1"

<400> 267
Thr Gly Ser Ser Ser Asn Ile Gly Ala Gly Tyr Asp Val His 
1               5                   10                  


<210> 268
<211> 42
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L1"

<400> 268
accgggagca gctccaacat cggggcaggt tatgatgtac ac                          42


<210> 269
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L2"

<400> 269
Ala Asn Asn Asn Arg Pro Ser 
1               5           


<210> 270
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L2"

<400> 270
gctaataaca atcggccctc a                                                 21


<210> 271
<211> 12
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L3"

<400> 271
Gln Ser Tyr Asp Leu Ser Leu Ser Ser Ser Arg Val 
1               5                   10          


<210> 272
<211> 36
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L3"

<400> 272
cagtcctatg acctcagtct gagtagttcg agggta                                 36


<210> 273
<211> 366
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region"

<400> 273
caggtccagc tggtgcagtc tgggggaggc gtggtccagc ctgggaggtc cctgaaacac       60

tcatgtgcag cctctggatt caccttcaat aactatgcta tacactgggt ccgccaggct      120

ccaggcaagg gcctggagtg ggtggcagct atctcatatg atggaagcaa tgaatactac      180

tcaaactccg tgaagggccg attcaccatc tccagagaca attccaagta cacgctgtat      240

ctgcaaatga acagcctgag acctgaggac acggctgtgt attactgtgc gagaggcgcc      300

tcctattact atgtgagtag tgaccttggc tactggggcc agggaaccct ggtcaccgtc      360

tcctca                                                                 366


<210> 274
<211> 122
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region"

<400> 274
Gln Val Gln Leu Val Gln Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Lys His Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Asn Tyr 
            20                  25                  30          


Ala Ile His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Ala Ile Ser Tyr Asp Gly Ser Asn Glu Tyr Tyr Ser Asn Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Tyr Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Ala Ser Tyr Tyr Tyr Val Ser Ser Asp Leu Gly Tyr Trp 
            100                 105                 110         


Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120         


<210> 275
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H1"

<400> 275
Phe Thr Phe Asn Asn Tyr Ala Ile His 
1               5                   


<210> 276
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H1"

<400> 276
ttcaccttca ataactatgc tatacac                                           27


<210> 277
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H2"

<400> 277
Ala Ile Ser Tyr Asp Gly Ser Asn Glu Tyr Tyr Ser Asn Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210> 278
<211> 51
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H2"

<400> 278
gctatctcat atgatggaag caatgaatac tactcaaact ccgtgaaggg c                51


<210> 279
<211> 15
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H3"

<400> 279
Ala Arg Gly Ala Ser Tyr Tyr Tyr Val Ser Ser Asp Leu Gly Tyr 
1               5                   10                  15  


<210> 280
<211> 45
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H3"

<400> 280
gcgagaggcg cctcctatta ctatgtgagt agtgaccttg gctac                       45


<210> 281
<211> 333
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region"

<400> 281
cagcctgtgc tgactcagcc gccctcagtg tctggggccc cagggcagag ggtcaccatc       60

tcctgcactg ggagcagctc caacatcggg tcaggttatg atgtgcactg gtatcagcag      120

cttccaggaa cagcccccaa agtcgtcatc tatggtaaca tcaatcggcc ctcaggggtc      180

cctgagcgat tctctggctc caagtctggc acctcagcct ccctggccat cactgggctc      240

caggctgagg atgaggctga ttattactgc cagtcctatg acagcctgag tgcctcttgg      300

gtgttcggcg gagggaccaa gctcaccgtc cta                                   333


<210> 282
<211> 111
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region"

<400> 282
Gln Pro Val Leu Thr Gln Pro Pro Ser Val Ser Gly Ala Pro Gly Gln 
1               5                   10                  15      


Arg Val Thr Ile Ser Cys Thr Gly Ser Ser Ser Asn Ile Gly Ser Gly 
            20                  25                  30          


Tyr Asp Val His Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Val 
        35                  40                  45              


Val Ile Tyr Gly Asn Ile Asn Arg Pro Ser Gly Val Pro Glu Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Thr Gly Leu 
65                  70                  75                  80  


Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Gln Ser Tyr Asp Ser Leu 
                85                  90                  95      


Ser Ala Ser Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 110     


<210> 283
<211> 14
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L1"

<400> 283
Thr Gly Ser Ser Ser Asn Ile Gly Ser Gly Tyr Asp Val His 
1               5                   10                  


<210> 284
<211> 42
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L1"

<400> 284
actgggagca gctccaacat cgggtcaggt tatgatgtgc ac                          42


<210> 285
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L2"

<400> 285
Gly Asn Ile Asn Arg Pro Ser 
1               5           


<210> 286
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L2"

<400> 286
ggtaacatca atcggccctc a                                                 21


<210> 287
<211> 11
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L3"

<400> 287
Gln Ser Tyr Asp Ser Leu Ser Ala Ser Trp Val 
1               5                   10      


<210> 288
<211> 33
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L3"

<400> 288
cagtcctatg acagcctgag tgcctcttgg gtg                                    33


<210> 289
<211> 348
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region"

<400> 289
caggtccagc ttgtgcagtc tggaccagag gtgaaaaaga ccagagagtc tctgaagatc       60

tactgtaagg gttctggata cagctttatc agccactgga tcggctgggt gcgccagaaa      120

cccgggaaag gcctggagtg gatggggatc atctatccgg gtgactctga caccagatac      180

agcccgtcct tccaaggcca ggtcgccatc tcagccgaca agtccatcaa caccgcctac      240

ctgcagtgga gcagcctgaa gtcctcggac accgccatat attactgtgc gagtgtaatg      300

cttcggggga ttatgtgggg ccagggaacc ctggtcaccg tctcctca                   348


<210> 290
<211> 116
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region"

<400> 290
Gln Val Gln Leu Val Gln Ser Gly Pro Glu Val Lys Lys Thr Arg Glu 
1               5                   10                  15      


Ser Leu Lys Ile Tyr Cys Lys Gly Ser Gly Tyr Ser Phe Ile Ser His 
            20                  25                  30          


Trp Ile Gly Trp Val Arg Gln Lys Pro Gly Lys Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Ile Ile Tyr Pro Gly Asp Ser Asp Thr Arg Tyr Ser Pro Ser Phe 
    50                  55                  60                  


Gln Gly Gln Val Ala Ile Ser Ala Asp Lys Ser Ile Asn Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Trp Ser Ser Leu Lys Ser Ser Asp Thr Ala Ile Tyr Tyr Cys 
                85                  90                  95      


Ala Ser Val Met Leu Arg Gly Ile Met Trp Gly Gln Gly Thr Leu Val 
            100                 105                 110         


Thr Val Ser Ser 
        115     


<210> 291
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H1"

<400> 291
Tyr Ser Phe Ile Ser His Trp Ile Gly 
1               5                   


<210> 292
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H1"

<400> 292
tacagcttta tcagccactg gatcggc                                           27


<210> 293
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H2"

<400> 293
Ile Ile Tyr Pro Gly Asp Ser Asp Thr Arg Tyr Ser Pro Ser Phe Gln 
1               5                   10                  15      


Gly 
    


<210> 294
<211> 51
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H2"

<400> 294
atcatctatc cgggtgactc tgacaccaga tacagcccgt ccttccaagg c                51


<210> 295
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H3"

<400> 295
Ala Ser Val Met Leu Arg Gly Ile Met 
1               5                   


<210> 296
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H3"

<400> 296
gcgagtgtaa tgcttcgggg gattatg                                           27


<210> 297
<211> 327
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region"

<400> 297
gacatccggt tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga cagagtcacc       60

atcacttgcc aggcgagtca ggacattagc aagtatctaa attggtatca gcagaaacca      120

gggaaagccc ctaagctcct gatctacgat gcatccaatt tggaaacagg ggtcccatca      180

agattcagtg gaagtggatc tgggacagat tttactttca ccatcagcag cctgcagcct      240

gaagatattg caacatatta ctgtcagccg tatgataatc tccctccgcc gctcactttc      300

ggcggaggga ccaagctgga gatcaaa                                          327


<210> 298
<211> 109
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region"

<400> 298
Asp Ile Arg Leu Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Gln Ala Ser Gln Asp Ile Ser Lys Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Asp Ala Ser Asn Leu Glu Thr Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Phe Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Ile Ala Thr Tyr Tyr Cys Gln Pro Tyr Asp Asn Leu Pro Pro 
                85                  90                  95      


Pro Leu Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 


<210> 299
<211> 11
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L1"

<400> 299
Gln Ala Ser Gln Asp Ile Ser Lys Tyr Leu Asn 
1               5                   10      


<210> 300
<211> 33
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L1"

<400> 300
caggcgagtc aggacattag caagtatcta aat                                    33


<210> 301
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L2"

<400> 301
Asp Ala Ser Asn Leu Glu Thr 
1               5           


<210> 302
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L2"

<400> 302
gatgcatcca atttggaaac a                                                 21


<210> 303
<211> 11
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L3"

<400> 303
Gln Pro Tyr Asp Asn Leu Pro Pro Pro Leu Thr 
1               5                   10      


<210> 304
<211> 33
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L3"

<400> 304
cagccgtatg ataatctccc tccgccgctc act                                    33


<210> 305
<211> 366
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region"

<400> 305
gaggtgcagc tgttggagtc tgggggaggc gtggtccagt ctgggaggtc cctgagactc       60

tcctgtgcag cgtctggatt caccttcagt gacaatggca tgcactgggt ccgccaggct      120

ccaggcaagg ggctggagtg ggtggcaggt atattttatg atggaagtaa taaacaatat      180

gcagactccg tgaagggccg attcaccatc tccagagaca attccaagag cacgctgtat      240

ctgcaaatga acagcctgag agccgaggac acggctgtgt attactgtgc gagagcccct      300

tacgatattt ggagtggtta ttgtcttgac tactggggcc agggaaccct ggtcaccgtc      360

tcctca                                                                 366


<210> 306
<211> 122
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region"

<400> 306
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Val Val Gln Ser Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp Asn 
            20                  25                  30          


Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Gly Ile Phe Tyr Asp Gly Ser Asn Lys Gln Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Ser Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ala Pro Tyr Asp Ile Trp Ser Gly Tyr Cys Leu Asp Tyr Trp 
            100                 105                 110         


Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120         


<210> 307
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H1"

<400> 307
Phe Thr Phe Ser Asp Asn Gly Met His 
1               5                   


<210> 308
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H1"

<400> 308
ttcaccttca gtgacaatgg catgcac                                           27


<210> 309
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H2"

<400> 309
Gly Ile Phe Tyr Asp Gly Ser Asn Lys Gln Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210> 310
<211> 51
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H2"

<400> 310
ggtatatttt atgatggaag taataaacaa tatgcagact ccgtgaaggg c                51


<210> 311
<211> 15
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H3"

<400> 311
Ala Arg Ala Pro Tyr Asp Ile Trp Ser Gly Tyr Cys Leu Asp Tyr 
1               5                   10                  15  


<210> 312
<211> 45
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H3"

<400> 312
gcgagagccc cttacgatat ttggagtggt tattgtcttg actac                       45


<210> 313
<211> 321
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region"

<400> 313
gacatccaga tgactcagac tccagccacc ctgtctatgt ctccagggga aagagccacc       60

ctctcctgca gggccagtca gagtgttaac aacaacttag cctggtacca gcagagacct      120

ggccaggctc ccaggctcct catctatggt gcatctacca gggccactgg tatcccagcc      180

aggttcagtg gcagtgggtc tgagacagag ttcactctca ctatcagcag cctgcagtct      240

gaagattttg cggtttatca ctgtcagcag tatagtatct ggcctcagac ttttggccag      300

gggaccaagc tggagatcaa a                                                321


<210> 314
<211> 107
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region"

<400> 314
Asp Ile Gln Met Thr Gln Thr Pro Ala Thr Leu Ser Met Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Asn Asn Asn 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Arg Pro Gly Gln Ala Pro Arg Leu Leu Ile 
        35                  40                  45              


Tyr Gly Ala Ser Thr Arg Ala Thr Gly Ile Pro Ala Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Glu Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Ser 
65                  70                  75                  80  


Glu Asp Phe Ala Val Tyr His Cys Gln Gln Tyr Ser Ile Trp Pro Gln 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210> 315
<211> 11
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L1"

<400> 315
Arg Ala Ser Gln Ser Val Asn Asn Asn Leu Ala 
1               5                   10      


<210> 316
<211> 33
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L1"

<400> 316
agggccagtc agagtgttaa caacaactta gcc                                    33


<210> 317
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L2"

<400> 317
Gly Ala Ser Thr Arg Ala Thr 
1               5           


<210> 318
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L2"

<400> 318
ggtgcatcta ccagggccac t                                                 21


<210> 319
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L3"

<400> 319
Gln Gln Tyr Ser Ile Trp Pro Gln Thr 
1               5                   


<210> 320
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L3"

<400> 320
cagcagtata gtatctggcc tcagact                                           27


<210> 321
<211> 384
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region"

<400> 321
gaggtgcagc tggtggagtc tgggggaggc ttggtccagc ctggggggtc cctgagactc       60

tcctgtgcag cctctggatt cactattgga acgtactgga tgagctgggt ccgccaggct      120

ccagggaagg ggctggagtg ggtggccaac ataaaaccag atggaagtga gcaatattat      180

ggggactcgg tgaagggccg attcaccatc tccagagaca acgccaagaa ttccctgtat      240

ctgcaaatgc acagcctgag agccgaggac gcggctgtct tttactgtgc gagggatact      300

cccgacgtat tacgacattt ggagtggccc cctgtaggtg cttttgatat ctggggccaa      360

gggaccacgg tcaccgtctc ctca                                             384


<210> 322
<211> 128
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region"

<400> 322
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Ile Gly Thr Tyr 
            20                  25                  30          


Trp Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Asn Ile Lys Pro Asp Gly Ser Glu Gln Tyr Tyr Gly Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met His Ser Leu Arg Ala Glu Asp Ala Ala Val Phe Tyr Cys 
                85                  90                  95      


Ala Arg Asp Thr Pro Asp Val Leu Arg His Leu Glu Trp Pro Pro Val 
            100                 105                 110         


Gly Ala Phe Asp Ile Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120                 125             


<210> 323
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H1"

<400> 323
Phe Thr Ile Gly Thr Tyr Trp Met Ser 
1               5                   


<210> 324
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H1"

<400> 324
ttcactattg gaacgtactg gatgagc                                           27


<210> 325
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H2"

<400> 325
Asn Ile Lys Pro Asp Gly Ser Glu Gln Tyr Tyr Gly Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210> 326
<211> 51
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H2"

<400> 326
aacataaaac cagatggaag tgagcaatat tatggggact cggtgaaggg c                51


<210> 327
<211> 21
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H3"

<400> 327
Ala Arg Asp Thr Pro Asp Val Leu Arg His Leu Glu Trp Pro Pro Val 
1               5                   10                  15      


Gly Ala Phe Asp Ile 
            20      


<210> 328
<211> 63
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H3"

<400> 328
gcgagggata ctcccgacgt attacgacat ttggagtggc cccctgtagg tgcttttgat       60

atc                                                                     63


<210> 329
<211> 339
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region"

<400> 329
gaaattgtaa tgacgcagtc tccagactcc ctggctgtgt ctctgggcga gagggccacc       60

atcaactgca agtccagcca gagtcttttc tacagctcca ccaatcagca ctacttggct      120

tggtaccagc agaaaccagg acagcctcct gagctgctca tttactgggc atctatccgg      180

gaatccgggg tccctgaccg attcagtggc agcgggtctg ggacagattt cactctcacc      240

atcagcagcc tgcaggccgc agatgtggca gtttattact gtcagcagta ttatagtagt      300

cctcaaactt ttggccaggg gaccaaggtg gaaatcaaa                             339


<210> 330
<211> 113
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region"

<400> 330
Glu Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Glu Arg Ala Thr Ile Asn Cys Lys Ser Ser Gln Ser Leu Phe Tyr Ser 
            20                  25                  30          


Ser Thr Asn Gln His Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Pro Pro Glu Leu Leu Ile Tyr Trp Ala Ser Ile Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Leu Gln Ala Ala Asp Val Ala Val Tyr Tyr Cys Gln Gln 
                85                  90                  95      


Tyr Tyr Ser Ser Pro Gln Thr Phe Gly Gln Gly Thr Lys Val Glu Ile 
            100                 105                 110         


Lys 
    


<210> 331
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L1"

<400> 331
Lys Ser Ser Gln Ser Leu Phe Tyr Ser Ser Thr Asn Gln His Tyr Leu 
1               5                   10                  15      


Ala 
    


<210> 332
<211> 51
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L1"

<400> 332
aagtccagcc agagtctttt ctacagctcc accaatcagc actacttggc t                51


<210> 333
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L2"

<400> 333
Trp Ala Ser Ile Arg Glu Ser 
1               5           


<210> 334
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L2"

<400> 334
tgggcatcta tccgggaatc c                                                 21


<210> 335
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L3"

<400> 335
Gln Gln Tyr Tyr Ser Ser Pro Gln Thr 
1               5                   


<210> 336
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L3"

<400> 336
cagcagtatt atagtagtcc tcaaact                                           27


<210> 337
<211> 363
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region"

<400> 337
caggtccagc ttgtgcagtc tggaactgag gtgaagaagc ctggggcctc agtgaaggtc       60

tcctgtaagg ctgctggtta cacctttagc aactacggtg tcagttgggt gcgacaggcc      120

cctggacagg ggcttgagtg gatgggatgg atcagcgctt ataatggtaa cacaaaattt      180

gcacagaagg tccagggcag actcaccatg accacagaca catctaccag cacagcctac      240

atggaattga ggaacctcag atctgacgac acggccgtgt attattgtgc gagagaatca      300

ggggcaacag cggctgctat gtttgactac tggggccagg gaaccctggt caccgtctcc      360

tca                                                                    363


<210> 338
<211> 121
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region"

<400> 338
Gln Val Gln Leu Val Gln Ser Gly Thr Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ala Gly Tyr Thr Phe Ser Asn Tyr 
            20                  25                  30          


Gly Val Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Ser Ala Tyr Asn Gly Asn Thr Lys Phe Ala Gln Lys Val 
    50                  55                  60                  


Gln Gly Arg Leu Thr Met Thr Thr Asp Thr Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Arg Asn Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Glu Ser Gly Ala Thr Ala Ala Ala Met Phe Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120     


<210> 339
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H1"

<400> 339
Tyr Thr Phe Ser Asn Tyr Gly Val Ser 
1               5                   


<210> 340
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H1"

<400> 340
tacaccttta gcaactacgg tgtcagt                                           27


<210> 341
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H2"

<400> 341
Trp Ile Ser Ala Tyr Asn Gly Asn Thr Lys Phe Ala Gln Lys Val Gln 
1               5                   10                  15      


Gly 
    


<210> 342
<211> 51
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H2"

<400> 342
tggatcagcg cttataatgg taacacaaaa tttgcacaga aggtccaggg c                51


<210> 343
<211> 14
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H3"

<400> 343
Ala Arg Glu Ser Gly Ala Thr Ala Ala Ala Met Phe Asp Tyr 
1               5                   10                  


<210> 344
<211> 42
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H3"

<400> 344
gcgagagaat caggggcaac agcggctgct atgtttgact ac                          42


<210> 345
<211> 336
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region"

<400> 345
gaaattgtat tgacgcagtc tccactctcc ctgcccgtca cccttggaca gccggcctcc       60

atctcctgca ggtctagtca aagcctcgaa tacagtgatg gaaacatcta cttgagttgg      120

tttcaacaga ggccaggcca atctccaagg cgcctaattt ataaggtttc tcaccgggac      180

tctggggtcc cagacagatt cagcggcagt gggtcaggca ctgatttcac actgaaaatc      240

gccagggtgg aggctgagga tgttgcagtt tattactgca tgcaagctat acactggcct      300

cgaacttttg gccaggggac caaggtggag atcaaa                                336


<210> 346
<211> 112
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region"

<400> 346
Glu Ile Val Leu Thr Gln Ser Pro Leu Ser Leu Pro Val Thr Leu Gly 
1               5                   10                  15      


Gln Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Glu Tyr Ser 
            20                  25                  30          


Asp Gly Asn Ile Tyr Leu Ser Trp Phe Gln Gln Arg Pro Gly Gln Ser 
        35                  40                  45              


Pro Arg Arg Leu Ile Tyr Lys Val Ser His Arg Asp Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ala Arg Val Glu Ala Glu Asp Val Ala Val Tyr Tyr Cys Met Gln Ala 
                85                  90                  95      


Ile His Trp Pro Arg Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105                 110         


<210> 347
<211> 16
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L1"

<400> 347
Arg Ser Ser Gln Ser Leu Glu Tyr Ser Asp Gly Asn Ile Tyr Leu Ser 
1               5                   10                  15      


<210> 348
<211> 48
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L1"

<400> 348
aggtctagtc aaagcctcga atacagtgat ggaaacatct acttgagt                    48


<210> 349
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L2"

<400> 349
Lys Val Ser His Arg Asp Ser 
1               5           


<210> 350
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L2"

<400> 350
aaggtttctc accgggactc t                                                 21


<210> 351
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L3"

<400> 351
Met Gln Ala Ile His Trp Pro Arg Thr 
1               5                   


<210> 352
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L3"

<400> 352
atgcaagcta tacactggcc tcgaact                                           27


<210> 353
<211> 366
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region"

<400> 353
gaggtgcagc tggtggagtc tgggggaggc gtggtccagt ctgggaggtc cctgagactc       60

tcctgtgcag cgtctggatt caccttcagt gacaatggca tgcactgggt ccgccaggct      120

ccaggcaagg ggctggagtg ggtggcaggt atattttatg atggaagtaa taaacaatat      180

gcagactccg tgaagggccg attcaccatc tccagagaca attccaagag cacgctgtat      240

ctgcaaatga acagcctgag agccgaggac acggctgtgt attactgtgc gagagcccct      300

tacgatattt ggagtggtta ttgtcttgac tactggggcc agggaaccct ggtcaccgtc      360

tcctca                                                                 366


<210> 354
<211> 122
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region"

<400> 354
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Ser Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp Asn 
            20                  25                  30          


Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Gly Ile Phe Tyr Asp Gly Ser Asn Lys Gln Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Ser Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ala Pro Tyr Asp Ile Trp Ser Gly Tyr Cys Leu Asp Tyr Trp 
            100                 105                 110         


Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120         


<210> 355
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H1"

<400> 355
Phe Thr Phe Ser Asp Asn Gly Met His 
1               5                   


<210> 356
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H1"

<400> 356
ttcaccttca gtgacaatgg catgcac                                           27


<210> 357
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H2"

<400> 357
Gly Ile Phe Tyr Asp Gly Ser Asn Lys Gln Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210> 358
<211> 51
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H2"

<400> 358
ggtatatttt atgatggaag taataaacaa tatgcagact ccgtgaaggg c                51


<210> 359
<211> 15
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H3"

<400> 359
Ala Arg Ala Pro Tyr Asp Ile Trp Ser Gly Tyr Cys Leu Asp Tyr 
1               5                   10                  15  


<210> 360
<211> 45
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H3"

<400> 360
gcgagagccc cttacgatat ttggagtggt tattgtcttg actac                       45


<210> 361
<211> 321
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region"

<400> 361
gacatccggt tgacccagtc tccagccacc ctgtctatgt ctccagggga aagagccacc       60

ctctcctgca gggccagtca gagtgttaac aacaacttag cctggtacca gcagagacct      120

ggccaggctc ccaggctcct catctatggt gcatctacca gggccactgg tatcccagcc      180

aggttcagtg gcagtgggtc tgagacagag ttcactctca ctatcagcag cctgcagtct      240

gaagattttg cggtttatca ctgtcagcag tatagtatct ggcctcagac ttttggccag      300

gggaccaaag tggatatcaa a                                                321


<210> 362
<211> 107
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region"

<400> 362
Asp Ile Arg Leu Thr Gln Ser Pro Ala Thr Leu Ser Met Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Asn Asn Asn 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Arg Pro Gly Gln Ala Pro Arg Leu Leu Ile 
        35                  40                  45              


Tyr Gly Ala Ser Thr Arg Ala Thr Gly Ile Pro Ala Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Glu Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Ser 
65                  70                  75                  80  


Glu Asp Phe Ala Val Tyr His Cys Gln Gln Tyr Ser Ile Trp Pro Gln 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Asp Ile Lys 
            100                 105         


<210> 363
<211> 11
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L1"

<400> 363
Arg Ala Ser Gln Ser Val Asn Asn Asn Leu Ala 
1               5                   10      


<210> 364
<211> 33
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L1"

<400> 364
agggccagtc agagtgttaa caacaactta gcc                                    33


<210> 365
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L2"

<400> 365
Gly Ala Ser Thr Arg Ala Thr 
1               5           


<210> 366
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L2"

<400> 366
ggtgcatcta ccagggccac t                                                 21


<210> 367
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L3"

<400> 367
Gln Gln Tyr Ser Ile Trp Pro Gln Thr 
1               5                   


<210> 368
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L3"

<400> 368
cagcagtata gtatctggcc tcagact                                           27


<210> 369
<211> 366
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region"

<400> 369
gaggtgcagc tgttggagtc tgggggagcc ttggtcgagc ctggggggtc cctgagactc       60

tcctgtgcag cctctggatt ctcctttaac acgtattcca tgaactgggt ccgccagggt      120

ccagggaagg gactggagtg ggtcgcaacg ataagtacga gtactgctgg ctcatactac      180

gcagactccg tgaggggccg gttcaccatc tctagagaca attccaagaa cacgttatat      240

ctgcaaatga acagtctgag agtcgaagac acggccgtat attactgtgc gagagatcag      300

gaagtggaac tgatcgatga tgcttttgat ttctggggcc gggggacaat ggtcaccgtc      360

tcttca                                                                 366


<210> 370
<211> 122
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region"

<400> 370
Glu Val Gln Leu Leu Glu Ser Gly Gly Ala Leu Val Glu Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ser Phe Asn Thr Tyr 
            20                  25                  30          


Ser Met Asn Trp Val Arg Gln Gly Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Thr Ile Ser Thr Ser Thr Ala Gly Ser Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Arg Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Val Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Gln Glu Val Glu Leu Ile Asp Asp Ala Phe Asp Phe Trp 
            100                 105                 110         


Gly Arg Gly Thr Met Val Thr Val Ser Ser 
        115                 120         


<210> 371
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H1"

<400> 371
Phe Ser Phe Asn Thr Tyr Ser Met Asn 
1               5                   


<210> 372
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H1"

<400> 372
ttctccttta acacgtattc catgaac                                           27


<210> 373
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H2"

<400> 373
Thr Ile Ser Thr Ser Thr Ala Gly Ser Tyr Tyr Ala Asp Ser Val Arg 
1               5                   10                  15      


Gly 
    


<210> 374
<211> 51
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H2"

<400> 374
acgataagta cgagtactgc tggctcatac tacgcagact ccgtgagggg c                51


<210> 375
<211> 15
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H3"

<400> 375
Ala Arg Asp Gln Glu Val Glu Leu Ile Asp Asp Ala Phe Asp Phe 
1               5                   10                  15  


<210> 376
<211> 45
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H3"

<400> 376
gcgagagatc aggaagtgga actgatcgat gatgcttttg atttc                       45


<210> 377
<211> 318
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region"

<400> 377
gatattgtga tgactcagac acattcctcc ctgtctgcat ctgtgggaga cagagtcacc       60

atcacttgcc gggccagtca gagtattagt atctgggtgg cctggtatca gcagaaacca      120

gggaaagccc ctaacctcct gatctataag gcgtctagtt tacaaagtgg ggtcccatca      180

aggttcagcg gcagtggatc tgggacagaa ttcactctca ccatcagcag cctgcagcct      240

gatgactctg caacttatta ctgccaacag tattacacct attacagttt tggccagggg      300

accaagctgg agatcaaa                                                    318


<210> 378
<211> 106
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region"

<400> 378
Asp Ile Val Met Thr Gln Thr His Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Ile Trp 
            20                  25                  30          


Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Asn Leu Leu Ile 
        35                  40                  45              


Tyr Lys Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Asp Asp Ser Ala Thr Tyr Tyr Cys Gln Gln Tyr Tyr Thr Tyr Tyr Ser 
                85                  90                  95      


Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105     


<210> 379
<211> 11
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L1"

<400> 379
Arg Ala Ser Gln Ser Ile Ser Ile Trp Val Ala 
1               5                   10      


<210> 380
<211> 33
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L1"

<400> 380
cgggccagtc agagtattag tatctgggtg gcc                                    33


<210> 381
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L2"

<400> 381
Lys Ala Ser Ser Leu Gln Ser 
1               5           


<210> 382
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L2"

<400> 382
aaggcgtcta gtttacaaag t                                                 21


<210> 383
<211> 8
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L3"

<400> 383
Gln Gln Tyr Tyr Thr Tyr Tyr Ser 
1               5               


<210> 384
<211> 24
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L3"

<400> 384
caacagtatt acacctatta cagt                                              24


<210> 385
<211> 363
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region"

<400> 385
gaggtgcagc tggtggagtc tggggctgag gtgaagaggc ctggggcctc agtgaaaatc       60

tcctgcaagg cttctgaata cgccttcacc gcccactatc ttcactgggt gcgacaggcc      120

cctgatcaag gacttgagtg gatgggatgg atcagcccta aaagtggtgg caccaactat      180

gcacagaagt ttcacggcag ggtcagcatg accagtgaca cgtccatcag tacagtctat      240

atggaactga gcagcctgac atctgacgac acggccgtct attactgtgc gagaagcagt      300

ctggtgggag caagccccaa ctttgacttc tggggccagg gaaccctggt caccgtctcc      360

tca                                                                    363


<210> 386
<211> 121
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region"

<400> 386
Glu Val Gln Leu Val Glu Ser Gly Ala Glu Val Lys Arg Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Ile Ser Cys Lys Ala Ser Glu Tyr Ala Phe Thr Ala His 
            20                  25                  30          


Tyr Leu His Trp Val Arg Gln Ala Pro Asp Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Ser Pro Lys Ser Gly Gly Thr Asn Tyr Ala Gln Lys Phe 
    50                  55                  60                  


His Gly Arg Val Ser Met Thr Ser Asp Thr Ser Ile Ser Thr Val Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Thr Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ser Ser Leu Val Gly Ala Ser Pro Asn Phe Asp Phe Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120     


<210> 387
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H1"

<400> 387
Tyr Ala Phe Thr Ala His Tyr Leu His 
1               5                   


<210> 388
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H1"

<400> 388
tacgccttca ccgcccacta tcttcac                                           27


<210> 389
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H2"

<400> 389
Trp Ile Ser Pro Lys Ser Gly Gly Thr Asn Tyr Ala Gln Lys Phe His 
1               5                   10                  15      


Gly 
    


<210> 390
<211> 51
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H2"

<400> 390
tggatcagcc ctaaaagtgg tggcaccaac tatgcacaga agtttcacgg c                51


<210> 391
<211> 14
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H3"

<400> 391
Ala Arg Ser Ser Leu Val Gly Ala Ser Pro Asn Phe Asp Phe 
1               5                   10                  


<210> 392
<211> 42
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H3"

<400> 392
gcgagaagca gtctggtggg agcaagcccc aactttgact tc                          42


<210> 393
<211> 333
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region"

<400> 393
cagtctgtgc tgacgcagcc gccctcagtg tctgcggccc caggacagag ggtcaccatc       60

tcctgctctg gaagcagctc caacattggg aataattatg tatcctggta ccagcaactc      120

ccaggaacta cccccaaagt cctcatttac gacaataatc agcgaccctc agggattcct      180

gaccgtttct ctggctccaa gtctggcacg tcagccaccc tggccatcag cggactccag      240

actggcgacg aggccgtcta ttattgcgga acatgggatg ccagcctgag tgctgctatg      300

gttttcggcg gggggaccaa gctcaccgtc cta                                   333


<210> 394
<211> 111
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region"

<400> 394
Gln Ser Val Leu Thr Gln Pro Pro Ser Val Ser Ala Ala Pro Gly Gln 
1               5                   10                  15      


Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn 
            20                  25                  30          


Tyr Val Ser Trp Tyr Gln Gln Leu Pro Gly Thr Thr Pro Lys Val Leu 
        35                  40                  45              


Ile Tyr Asp Asn Asn Gln Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Lys Ser Gly Thr Ser Ala Thr Leu Ala Ile Ser Gly Leu Gln 
65                  70                  75                  80  


Thr Gly Asp Glu Ala Val Tyr Tyr Cys Gly Thr Trp Asp Ala Ser Leu 
                85                  90                  95      


Ser Ala Ala Met Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 110     


<210> 395
<211> 13
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L1"

<400> 395
Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn Tyr Val Ser 
1               5                   10              


<210> 396
<211> 39
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L1"

<400> 396
tctggaagca gctccaacat tgggaataat tatgtatcc                              39


<210> 397
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L2"

<400> 397
Asp Asn Asn Gln Arg Pro Ser 
1               5           


<210> 398
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L2"

<400> 398
gacaataatc agcgaccctc a                                                 21


<210> 399
<211> 12
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L3"

<400> 399
Gly Thr Trp Asp Ala Ser Leu Ser Ala Ala Met Val 
1               5                   10          


<210> 400
<211> 36
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L3"

<400> 400
ggaacatggg atgccagcct gagtgctgct atggtt                                 36


<210> 401
<211> 363
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region"

<400> 401
caggtgcagc tgcaggagtc gggcccagga ctggtgaagc cttcggagac cctgtccctc       60

acctgcactg tctctggtgg ctccatcagc ggatattact ggagctggat ccggcagccc      120

ccagggaggg gactggagtg gattgggttt atttattata gtgggagtac cagctacgac      180

tcctccctca agagtcgagt caccatatca gtagacacgt ccaagaacca gttctcccta      240

aacctgagct ctgtgaccgc tgcggacacg gccgtatatt actgtgcgag aagtacatgg      300

gactacggtg accactttcc gtttgactac tggggccagg gaaccctggt caccgtctcc      360

tca                                                                    363


<210> 402
<211> 121
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region"

<400> 402
Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Gly Ser Ile Ser Gly Tyr 
            20                  25                  30          


Tyr Trp Ser Trp Ile Arg Gln Pro Pro Gly Arg Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Phe Ile Tyr Tyr Ser Gly Ser Thr Ser Tyr Asp Ser Ser Leu Lys 
    50                  55                  60                  


Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe Ser Leu 
65                  70                  75                  80  


Asn Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Ser Thr Trp Asp Tyr Gly Asp His Phe Pro Phe Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120     


<210> 403
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H1"

<400> 403
Gly Ser Ile Ser Gly Tyr Tyr Trp Ser 
1               5                   


<210> 404
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H1"

<400> 404
ggctccatca gcggatatta ctggagc                                           27


<210> 405
<211> 16
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H2"

<400> 405
Phe Ile Tyr Tyr Ser Gly Ser Thr Ser Tyr Asp Ser Ser Leu Lys Ser 
1               5                   10                  15      


<210> 406
<211> 48
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H2"

<400> 406
tttatttatt atagtgggag taccagctac gactcctccc tcaagagt                    48


<210> 407
<211> 15
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H3"

<400> 407
Ala Arg Ser Thr Trp Asp Tyr Gly Asp His Phe Pro Phe Asp Tyr 
1               5                   10                  15  


<210> 408
<211> 45
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H3"

<400> 408
gcgagaagta catgggacta cggtgaccac tttccgtttg actac                       45


<210> 409
<211> 327
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region"

<400> 409
tcctatgagc tgactcagcc accctcagtg tcagtggccc caggaaagac ggccaggatt       60

acctgtgggg gaaacaacat tggaattaaa gatgtgcact ggtaccaact gaggccaggc      120

caggcccctg tgttggtcat ctcttatgat agcgaccggc cctcagggat ccctgagcga      180

ttctctggct ccaactctgg gaacacggcc accctgacca tcagcagggt cgaagccggg      240

gatgaggccg actatttctg tcaggtgtgg gatagtagtc ctgatcatcc ttatgtcttc      300

ggaactggga ccaagctcac cgtccta                                          327


<210> 410
<211> 109
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region"

<400> 410
Ser Tyr Glu Leu Thr Gln Pro Pro Ser Val Ser Val Ala Pro Gly Lys 
1               5                   10                  15      


Thr Ala Arg Ile Thr Cys Gly Gly Asn Asn Ile Gly Ile Lys Asp Val 
            20                  25                  30          


His Trp Tyr Gln Leu Arg Pro Gly Gln Ala Pro Val Leu Val Ile Ser 
        35                  40                  45              


Tyr Asp Ser Asp Arg Pro Ser Gly Ile Pro Glu Arg Phe Ser Gly Ser 
    50                  55                  60                  


Asn Ser Gly Asn Thr Ala Thr Leu Thr Ile Ser Arg Val Glu Ala Gly 
65                  70                  75                  80  


Asp Glu Ala Asp Tyr Phe Cys Gln Val Trp Asp Ser Ser Pro Asp His 
                85                  90                  95      


Pro Tyr Val Phe Gly Thr Gly Thr Lys Leu Thr Val Leu 
            100                 105                 


<210> 411
<211> 11
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L1"

<400> 411
Gly Gly Asn Asn Ile Gly Ile Lys Asp Val His 
1               5                   10      


<210> 412
<211> 33
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L1"

<400> 412
gggggaaaca acattggaat taaagatgtg cac                                    33


<210> 413
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L2"

<400> 413
Tyr Asp Ser Asp Arg Pro Ser 
1               5           


<210> 414
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L2"

<400> 414
tatgatagcg accggccctc a                                                 21


<210> 415
<211> 12
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L3"

<400> 415
Gln Val Trp Asp Ser Ser Pro Asp His Pro Tyr Val 
1               5                   10          


<210> 416
<211> 36
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L3"

<400> 416
caggtgtggg atagtagtcc tgatcatcct tatgtc                                 36


<210> 417
<211> 363
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region"

<400> 417
gaggtgcagc tggtggagtc tggaggtgag gtgaagaagc ctggggcctc agtgaaggtc       60

tcctgcaggg cctctggtta cacctttaga aactatggcc tcacctgggt gcggcaggcc      120

cccggacaag ggcttgagtg gatgggatgg atcagcgctt acaatggaaa cacaaactat      180

gcacagaagt tccagggcag agtcacactg accacggaca catccacgag cacagcctac      240

atggaactga ggagcctaag atctgacgac acggccgtgt atttctgtgc gagagacgtc      300

cccggccacg gcgctgcctt catggacgtc tggggcacag ggaccacggt caccgtctcc      360

tca                                                                    363


<210> 418
<211> 121
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region"

<400> 418
Glu Val Gln Leu Val Glu Ser Gly Gly Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Arg Ala Ser Gly Tyr Thr Phe Arg Asn Tyr 
            20                  25                  30          


Gly Leu Thr Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Ser Ala Tyr Asn Gly Asn Thr Asn Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Leu Thr Thr Asp Thr Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Arg Ser Leu Arg Ser Asp Asp Thr Ala Val Tyr Phe Cys 
                85                  90                  95      


Ala Arg Asp Val Pro Gly His Gly Ala Ala Phe Met Asp Val Trp Gly 
            100                 105                 110         


Thr Gly Thr Thr Val Thr Val Ser Ser 
        115                 120     


<210> 419
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H1"

<400> 419
Tyr Thr Phe Arg Asn Tyr Gly Leu Thr 
1               5                   


<210> 420
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H1"

<400> 420
tacaccttta gaaactatgg cctcacc                                           27


<210> 421
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H2"

<400> 421
Trp Ile Ser Ala Tyr Asn Gly Asn Thr Asn Tyr Ala Gln Lys Phe Gln 
1               5                   10                  15      


Gly 
    


<210> 422
<211> 51
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H2"

<400> 422
tggatcagcg cttacaatgg aaacacaaac tatgcacaga agttccaggg c                51


<210> 423
<211> 14
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H3"

<400> 423
Ala Arg Asp Val Pro Gly His Gly Ala Ala Phe Met Asp Val 
1               5                   10                  


<210> 424
<211> 42
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H3"

<400> 424
gcgagagacg tccccggcca cggcgctgcc ttcatggacg tc                          42


<210> 425
<211> 336
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region"

<400> 425
gaaacgacac tcacgcagtc tccactctcc ctgcccgtca cccttgggca gccggcctcc       60

atctcctgca ggtctagtca aagcctcgaa gccagtgata caaatatcta cttgagttgg      120

tttcagcaga ggccaggcca atctccaagg cgcctaattt ataagatttc taaccgagac      180

tctggggtcc cagacagatt cagcggcagt gggtcaggca ctcatttcac actgagaatc      240

agcagggtgg aggctgacga tgttgcggtt tattactgca tgcagggtac acactggcct      300

ccggcgttcg gccaggggac caagctggag atcaaa                                336


<210> 426
<211> 112
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region"

<400> 426
Glu Thr Thr Leu Thr Gln Ser Pro Leu Ser Leu Pro Val Thr Leu Gly 
1               5                   10                  15      


Gln Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Glu Ala Ser 
            20                  25                  30          


Asp Thr Asn Ile Tyr Leu Ser Trp Phe Gln Gln Arg Pro Gly Gln Ser 
        35                  40                  45              


Pro Arg Arg Leu Ile Tyr Lys Ile Ser Asn Arg Asp Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr His Phe Thr Leu Arg Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Asp Asp Val Ala Val Tyr Tyr Cys Met Gln Gly 
                85                  90                  95      


Thr His Trp Pro Pro Ala Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


<210> 427
<211> 16
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L1"

<400> 427
Arg Ser Ser Gln Ser Leu Glu Ala Ser Asp Thr Asn Ile Tyr Leu Ser 
1               5                   10                  15      


<210> 428
<211> 48
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L1"

<400> 428
aggtctagtc aaagcctcga agccagtgat acaaatatct acttgagt                    48


<210> 429
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L2"

<400> 429
Lys Ile Ser Asn Arg Asp Ser 
1               5           


<210> 430
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L2"

<400> 430
aagatttcta accgagactc t                                                 21


<210> 431
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L3"

<400> 431
Met Gln Gly Thr His Trp Pro Pro Ala 
1               5                   


<210> 432
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L3"

<400> 432
atgcagggta cacactggcc tccggcg                                           27


<210> 433
<211> 363
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region"

<400> 433
gaggtgcagc tggtggagtc tggatctgag gtgaagaagc ctggggccgc agtgaaggta       60

tcctgcaagg cttctggtta catctttgcc aactttggtg tcagctgggt gcgacaggcc      120

cctggacaag ggcttgagtg gatgggatgg atcagcgctt acaatggtaa cacaaactat      180

gcacagaagt tccagggcag agtcatcatg accacagaca catccacgag cacagcctac      240

atggagctga ggagcctgag atctgacgac acggccgtgt attattgtgc gagagacccc      300

cccgcctacg ccgctacatt gatggacgtc tggggcaaag ggaccacggt caccgtctcc      360

tca                                                                    363


<210> 434
<211> 121
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region"

<400> 434
Glu Val Gln Leu Val Glu Ser Gly Ser Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ala Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Ile Phe Ala Asn Phe 
            20                  25                  30          


Gly Val Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Ser Ala Tyr Asn Gly Asn Thr Asn Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Ile Met Thr Thr Asp Thr Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Arg Ser Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Pro Pro Ala Tyr Ala Ala Thr Leu Met Asp Val Trp Gly 
            100                 105                 110         


Lys Gly Thr Thr Val Thr Val Ser Ser 
        115                 120     


<210> 435
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H1"

<400> 435
Tyr Ile Phe Ala Asn Phe Gly Val Ser 
1               5                   


<210> 436
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H1"

<400> 436
tacatctttg ccaactttgg tgtcagc                                           27


<210> 437
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H2"

<400> 437
Trp Ile Ser Ala Tyr Asn Gly Asn Thr Asn Tyr Ala Gln Lys Phe Gln 
1               5                   10                  15      


Gly 
    


<210> 438
<211> 51
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H2"

<400> 438
tggatcagcg cttacaatgg taacacaaac tatgcacaga agttccaggg c                51


<210> 439
<211> 14
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H3"

<400> 439
Ala Arg Asp Pro Pro Ala Tyr Ala Ala Thr Leu Met Asp Val 
1               5                   10                  


<210> 440
<211> 42
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H3"

<400> 440
gcgagagacc cccccgccta cgccgctaca ttgatggacg tc                          42


<210> 441
<211> 336
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region"

<400> 441
gatattgtga tgactcagtc tccactctcc ctgcccgtca cccttggaca gtcggcctcc       60

atctcctgca ggtctagtca aagcctcgaa cacagtgata caaacaccta cttgacttgg      120

tatcagcaga ggccaggcca atctccaagg cggctacttt ataaggtttc taaccgggac      180

tctggggtcc cagacagatt cagcggcagt gggtcaggca ctgatttcac actgaaaatc      240

agcagggtgg aggctgagga tgttggggtt tattactgca tgcaaggtac acactggcct      300

ccgacgttcg gccaagggac caagctggag atcaaa                                336


<210> 442
<211> 112
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region"

<400> 442
Asp Ile Val Met Thr Gln Ser Pro Leu Ser Leu Pro Val Thr Leu Gly 
1               5                   10                  15      


Gln Ser Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Glu His Ser 
            20                  25                  30          


Asp Thr Asn Thr Tyr Leu Thr Trp Tyr Gln Gln Arg Pro Gly Gln Ser 
        35                  40                  45              


Pro Arg Arg Leu Leu Tyr Lys Val Ser Asn Arg Asp Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Met Gln Gly 
                85                  90                  95      


Thr His Trp Pro Pro Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


<210> 443
<211> 16
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L1"

<400> 443
Arg Ser Ser Gln Ser Leu Glu His Ser Asp Thr Asn Thr Tyr Leu Thr 
1               5                   10                  15      


<210> 444
<211> 48
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L1"

<400> 444
aggtctagtc aaagcctcga acacagtgat acaaacacct acttgact                    48


<210> 445
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L2"

<400> 445
Lys Val Ser Asn Arg Asp Ser 
1               5           


<210> 446
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L2"

<400> 446
aaggtttcta accgggactc t                                                 21


<210> 447
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L3"

<400> 447
Met Gln Gly Thr His Trp Pro Pro Thr 
1               5                   


<210> 448
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L3"

<400> 448
atgcaaggta cacactggcc tccgacg                                           27


<210> 449
<211> 399
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region"

<400> 449
gaggtgcagc tggtggagtc tggcccaaca ctggtgaagc cttcggagac cctgtccctc       60

acctgcgttg tctctggtgg ctccgtctac aggagtagta actactgggc ctggatccgc      120

cagcccccag ggaaggggct ggagtggatc gggagtgtct atcatagtgg gaacccctac      180

tccaacccgt cccttcagag tcgagtctcc gtctccattg acacgtccaa gaaccagttc      240

tccctgaagc tgtactctgt gaccgccgca gactcggcta tttattattg tgcgtgtaaa      300

agagcggacg ctgacgacgt agattacgtg gcgggcctca ccggtttccc ctggtacttc      360

gatgtctggg gccgtggcac cctggtcacc gtctcctca                             399


<210> 450
<211> 133
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region"

<400> 450
Glu Val Gln Leu Val Glu Ser Gly Pro Thr Leu Val Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Val Val Ser Gly Gly Ser Val Tyr Arg Ser 
            20                  25                  30          


Ser Asn Tyr Trp Ala Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu 
        35                  40                  45              


Trp Ile Gly Ser Val Tyr His Ser Gly Asn Pro Tyr Ser Asn Pro Ser 
    50                  55                  60                  


Leu Gln Ser Arg Val Ser Val Ser Ile Asp Thr Ser Lys Asn Gln Phe 
65                  70                  75                  80  


Ser Leu Lys Leu Tyr Ser Val Thr Ala Ala Asp Ser Ala Ile Tyr Tyr 
                85                  90                  95      


Cys Ala Cys Lys Arg Ala Asp Ala Asp Asp Val Asp Tyr Val Ala Gly 
            100                 105                 110         


Leu Thr Gly Phe Pro Trp Tyr Phe Asp Val Trp Gly Arg Gly Thr Leu 
        115                 120                 125             


Val Thr Val Ser Ser 
    130             


<210> 451
<211> 11
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H1"

<400> 451
Gly Ser Val Tyr Arg Ser Ser Asn Tyr Trp Ala 
1               5                   10      


<210> 452
<211> 33
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H1"

<400> 452
ggctccgtct acaggagtag taactactgg gcc                                    33


<210> 453
<211> 16
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H2"

<400> 453
Ser Val Tyr His Ser Gly Asn Pro Tyr Ser Asn Pro Ser Leu Gln Ser 
1               5                   10                  15      


<210> 454
<211> 48
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H2"

<400> 454
agtgtctatc atagtgggaa cccctactcc aacccgtccc ttcagagt                    48


<210> 455
<211> 25
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H3"

<400> 455
Ala Cys Lys Arg Ala Asp Ala Asp Asp Val Asp Tyr Val Ala Gly Leu 
1               5                   10                  15      


Thr Gly Phe Pro Trp Tyr Phe Asp Val 
            20                  25  


<210> 456
<211> 75
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H3"

<400> 456
gcgtgtaaaa gagcggacgc tgacgacgta gattacgtgg cgggcctcac cggtttcccc       60

tggtacttcg atgtc                                                        75


<210> 457
<211> 324
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region"

<400> 457
gaaattgtgt tgacgcagtc tccgtccacc ctgtctgcat ctgtgggaga cagagtcacc       60

atcacttgcc gggccagtca gagtattagt agttggttgg cctggtatca gcagaaacca      120

gggaaaaccc ctaagttgct catctataag gcgtctactt tagaaagtgg ggtcccatca      180

aggttcagcg gcagcggatc tgggacagaa ttcactctca ccatcagcag cctgcagcct      240

gatgatttcg caacctacta ctgccaacag tatcatgttt atttcccgct cactttcggc      300

ggagggacca aggtggaaat caaa                                             324


<210> 458
<211> 108
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region"

<400> 458
Glu Ile Val Leu Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Trp 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Thr Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Lys Ala Ser Thr Leu Glu Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Asp Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr His Val Tyr Phe Pro 
                85                  90                  95      


Leu Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105             


<210> 459
<211> 11
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L1"

<400> 459
Arg Ala Ser Gln Ser Ile Ser Ser Trp Leu Ala 
1               5                   10      


<210> 460
<211> 33
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L1"

<400> 460
cgggccagtc agagtattag tagttggttg gcc                                    33


<210> 461
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L2"

<400> 461
Lys Ala Ser Thr Leu Glu Ser 
1               5           


<210> 462
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L2"

<400> 462
aaggcgtcta ctttagaaag t                                                 21


<210> 463
<211> 10
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L3"

<400> 463
Gln Gln Tyr His Val Tyr Phe Pro Leu Thr 
1               5                   10  


<210> 464
<211> 30
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L3"

<400> 464
caacagtatc atgtttattt cccgctcact                                        30


<210> 465
<211> 360
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region"

<400> 465
gaggtgcagc tggtggagtc tgggggaggc gtggtccagc ctgggaggtc cctgagactc       60

tcctgtgtag cgtctggatt cagcttcagt atgcatggca tgcactgggt ccgccaggct      120

ccaggcaagg ggctggagtg ggtgacagct atatggtatg atggaagtaa taaatattat      180

gcagactccg tgaagggccg attcacgatc tccagagaca attctaggaa cacgctgtat      240

ctgcaaatga acagcctgag agccgaggac acggctgtgt attactgtgc gagagatcat      300

gcctcaactc catactacat ggacgtctgg ggcaaaggga ccacggtcac cgtctcttca      360


<210> 466
<211> 120
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region"

<400> 466
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Val Ala Ser Gly Phe Ser Phe Ser Met His 
            20                  25                  30          


Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Thr Ala Ile Trp Tyr Asp Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Arg Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp His Ala Ser Thr Pro Tyr Tyr Met Asp Val Trp Gly Lys 
            100                 105                 110         


Gly Thr Thr Val Thr Val Ser Ser 
        115                 120 


<210> 467
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H1"

<400> 467
Phe Ser Phe Ser Met His Gly Met His 
1               5                   


<210> 468
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H1"

<400> 468
ttcagcttca gtatgcatgg catgcac                                           27


<210> 469
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H2"

<400> 469
Ala Ile Trp Tyr Asp Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210> 470
<211> 51
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H2"

<400> 470
gctatatggt atgatggaag taataaatat tatgcagact ccgtgaaggg c                51


<210> 471
<211> 13
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H3"

<400> 471
Ala Arg Asp His Ala Ser Thr Pro Tyr Tyr Met Asp Val 
1               5                   10              


<210> 472
<211> 39
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H3"

<400> 472
gcgagagatc atgcctcaac tccatactac atggacgtc                              39


<210> 473
<211> 324
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region"

<400> 473
gaaacgacac tcacgcagtc tccaggcacc ctgtctttgt ctccagggga aagcgccacc       60

ctctcctgca ggaccagtca gaggattagc agcacctact tagcctggta ccggcagaaa      120

cctggccagg ctcccaggct cctcatgtat ggtgcatcca gcagggccac tggcatcccg      180

gacaggttca gtggcagtgg gtctgggaca gacttcactc tcaccatcag cagtctggag      240

cctgaagatt ttgcactata ttactgtcag cagtatggta gctttccgtg gacgttcggc      300

caagggacca aggtggaaat caaa                                             324


<210> 474
<211> 108
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region"

<400> 474
Glu Thr Thr Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Ser Ala Thr Leu Ser Cys Arg Thr Ser Gln Arg Ile Ser Ser Thr 
            20                  25                  30          


Tyr Leu Ala Trp Tyr Arg Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu 
        35                  40                  45              


Met Tyr Gly Ala Ser Ser Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu 
65                  70                  75                  80  


Pro Glu Asp Phe Ala Leu Tyr Tyr Cys Gln Gln Tyr Gly Ser Phe Pro 
                85                  90                  95      


Trp Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105             


<210> 475
<211> 12
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L1"

<400> 475
Arg Thr Ser Gln Arg Ile Ser Ser Thr Tyr Leu Ala 
1               5                   10          


<210> 476
<211> 36
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L1"

<400> 476
aggaccagtc agaggattag cagcacctac ttagcc                                 36


<210> 477
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L2"

<400> 477
Gly Ala Ser Ser Arg Ala Thr 
1               5           


<210> 478
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L2"

<400> 478
ggtgcatcca gcagggccac t                                                 21


<210> 479
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L3"

<400> 479
Gln Gln Tyr Gly Ser Phe Pro Trp Thr 
1               5                   


<210> 480
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L3"

<400> 480
cagcagtatg gtagctttcc gtggacg                                           27


<210> 481
<211> 360
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region"

<400> 481
caggtccagc tggtgcagtc tgggcctgag gtgaagaagc ctgggtcctc ggtgaaggtc       60

tcctgcaagg cttctggagg caccttcagc agttatgcta tcacgtgggt gcgacaggcc      120

cctggacaag ggcttgagtg gatggggggg atcatccctt cctttgatag agtggactat      180

tcacggaact tcaaggggag agtcaccttt accgcggaca aatccgcgaa cacggcctac      240

atggaactga ccaatgtgag atccgacgac acggccgtgt attactgtgc gagaggctgt      300

tgtggggctg tggctggatt ccagcactgg ggccagggca ccggggtcac cgtctcctca      360


<210> 482
<211> 120
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region"

<400> 482
Gln Val Gln Leu Val Gln Ser Gly Pro Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Ile Thr Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Gly Ile Ile Pro Ser Phe Asp Arg Val Asp Tyr Ser Arg Asn Phe 
    50                  55                  60                  


Lys Gly Arg Val Thr Phe Thr Ala Asp Lys Ser Ala Asn Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Thr Asn Val Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Cys Cys Gly Ala Val Ala Gly Phe Gln His Trp Gly Gln 
            100                 105                 110         


Gly Thr Gly Val Thr Val Ser Ser 
        115                 120 


<210> 483
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H1"

<400> 483
Gly Thr Phe Ser Ser Tyr Ala Ile Thr 
1               5                   


<210> 484
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H1"

<400> 484
ggcaccttca gcagttatgc tatcacg                                           27


<210> 485
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H2"

<400> 485
Gly Ile Ile Pro Ser Phe Asp Arg Val Asp Tyr Ser Arg Asn Phe Lys 
1               5                   10                  15      


Gly 
    


<210> 486
<211> 51
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H2"

<400> 486
gggatcatcc cttcctttga tagagtggac tattcacgga acttcaaggg g                51


<210> 487
<211> 13
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H3"

<400> 487
Ala Arg Gly Cys Cys Gly Ala Val Ala Gly Phe Gln His 
1               5                   10              


<210> 488
<211> 39
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H3"

<400> 488
gcgagaggct gttgtggggc tgtggctgga ttccagcac                              39


<210> 489
<211> 318
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region"

<400> 489
gatattgtgc tgacgcagac tccagccacc ctgtctttat ctccagggga aacagccacc       60

ctctcctgca gggccagtca gagtgttacc acctacttag cctggtacca gcagaaacct      120

ggccaggctc ccaggctcct catctatgat gcatccaaca gggccactgg cgtcccaacc      180

aggttcagtg gcagtgggtc tgggacagac ttcactctca ccatcagcag cctggagcct      240

gaagattatg cgatttatta ctgtcagcaa cgtactaccg gggtcacttt cggcgggggg      300

accaaggtgg aaatcaaa                                                    318


<210> 490
<211> 106
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region"

<400> 490
Asp Ile Val Leu Thr Gln Thr Pro Ala Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Thr Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Thr Thr Tyr 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 
        35                  40                  45              


Tyr Asp Ala Ser Asn Arg Ala Thr Gly Val Pro Thr Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu Pro 
65                  70                  75                  80  


Glu Asp Tyr Ala Ile Tyr Tyr Cys Gln Gln Arg Thr Thr Gly Val Thr 
                85                  90                  95      


Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105     


<210> 491
<211> 11
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L1"

<400> 491
Arg Ala Ser Gln Ser Val Thr Thr Tyr Leu Ala 
1               5                   10      


<210> 492
<211> 33
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L1"

<400> 492
agggccagtc agagtgttac cacctactta gcc                                    33


<210> 493
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L2"

<400> 493
Asp Ala Ser Asn Arg Ala Thr 
1               5           


<210> 494
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L2"

<400> 494
gatgcatcca acagggccac t                                                 21


<210> 495
<211> 8
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L3"

<400> 495
Gln Gln Arg Thr Thr Gly Val Thr 
1               5               


<210> 496
<211> 24
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L3"

<400> 496
cagcaacgta ctaccggggt cact                                              24


<210> 497
<211> 369
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region"

<400> 497
caggtgcagc tggtggagtc tgggggaggc ctggtcaagc ctggggggtc cctgagactc       60

tcttgtgcag cctctggatt caccttcagt agttttggca tgcattgggt ccgccaggct      120

ccagggcagg gactggagtg ggtcgcatcc attactggtg gcagcagtta cataaactac      180

gcagactcag tgaagggccg attcaccatc tccagagaca acgccaagaa gtcactgtct      240

ctgcaaatga agaacctgag agccgaggac acggctgagt attactgtgt gcgaggagtc      300

ctaccaggtg gtactggggg gggctggttc gactcctggg gccagggaac cctggtcacc      360

gtctcctca                                                              369


<210> 498
<211> 123
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region"

<400> 498
Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Phe 
            20                  25                  30          


Gly Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Ser Ile Thr Gly Gly Ser Ser Tyr Ile Asn Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Lys Ser Leu Ser 
65                  70                  75                  80  


Leu Gln Met Lys Asn Leu Arg Ala Glu Asp Thr Ala Glu Tyr Tyr Cys 
                85                  90                  95      


Val Arg Gly Val Leu Pro Gly Gly Thr Gly Gly Gly Trp Phe Asp Ser 
            100                 105                 110         


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120             


<210> 499
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H1"

<400> 499
Phe Thr Phe Ser Ser Phe Gly Met His 
1               5                   


<210> 500
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H1"

<400> 500
ttcaccttca gtagttttgg catgcat                                           27


<210> 501
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H2"

<400> 501
Ser Ile Thr Gly Gly Ser Ser Tyr Ile Asn Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210> 502
<211> 51
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H2"

<400> 502
tccattactg gtggcagcag ttacataaac tacgcagact cagtgaaggg c                51


<210> 503
<211> 16
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H3"

<400> 503
Val Arg Gly Val Leu Pro Gly Gly Thr Gly Gly Gly Trp Phe Asp Ser 
1               5                   10                  15      


<210> 504
<211> 48
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H3"

<400> 504
gtgcgaggag tcctaccagg tggtactggg gggggctggt tcgactcc                    48


<210> 505
<211> 330
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region"

<400> 505
cagtctgtcc tgactcagcc gccctcaatg tctggggccc cagggcagag ggtcaccatc       60

tcctgcactg ggaccagctc caacatcggg gcgggttatg atgtacagtg gtatcagcag      120

tttccaggaa cagcccccaa actcctcatc tctggtaaca acaatcggcc ctcaggggtc      180

cctgaccgat tctctggctc caagtctggc gcctcagcct ccctggccat cactgggctc      240

caggctgagg atgaggctga ttattactgc cagtcctatg actacagcct gaattgggtg      300

ttcggcggag ggaccaagct caccgtccta                                       330


<210> 506
<211> 110
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region"

<400> 506
Gln Ser Val Leu Thr Gln Pro Pro Ser Met Ser Gly Ala Pro Gly Gln 
1               5                   10                  15      


Arg Val Thr Ile Ser Cys Thr Gly Thr Ser Ser Asn Ile Gly Ala Gly 
            20                  25                  30          


Tyr Asp Val Gln Trp Tyr Gln Gln Phe Pro Gly Thr Ala Pro Lys Leu 
        35                  40                  45              


Leu Ile Ser Gly Asn Asn Asn Arg Pro Ser Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Ala Ser Ala Ser Leu Ala Ile Thr Gly Leu 
65                  70                  75                  80  


Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Gln Ser Tyr Asp Tyr Ser 
                85                  90                  95      


Leu Asn Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 110 


<210> 507
<211> 14
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L1"

<400> 507
Thr Gly Thr Ser Ser Asn Ile Gly Ala Gly Tyr Asp Val Gln 
1               5                   10                  


<210> 508
<211> 42
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L1"

<400> 508
actgggacca gctccaacat cggggcgggt tatgatgtac ag                          42


<210> 509
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L2"

<400> 509
Gly Asn Asn Asn Arg Pro Ser 
1               5           


<210> 510
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L2"

<400> 510
ggtaacaaca atcggccctc a                                                 21


<210> 511
<211> 10
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L3"

<400> 511
Gln Ser Tyr Asp Tyr Ser Leu Asn Trp Val 
1               5                   10  


<210> 512
<211> 30
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L3"

<400> 512
cagtcctatg actacagcct gaattgggtg                                        30


<210> 513
<211> 381
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region"

<400> 513
caggtgcagc tgcaggagtc gggcccagga ctggtgaagc cttcacagac cctgtcgctc       60

acctgcactg tctctggtcg cttcctcaat agtggtgatt actactggag ttggatccgc      120

cagtccccag ggaagggcct ggagtggctt ggttacatcc atcacagtgg gaacacctac      180

tacaacccgt ccctcaagag tcgacttacc atatcactag acatgtccaa gaaccagttc      240

tccctgaagt tgagctctgt gacagccgca gacacggccg tctattactg tgccagagat      300

ttgggaaagc cgctttggga cggccactat tactacggag tggacgtctg gggccaaggg      360

accacggtca ccgtctcctc a                                                381


<210> 514
<211> 127
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region"

<400> 514
Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Arg Phe Leu Asn Ser Gly 
            20                  25                  30          


Asp Tyr Tyr Trp Ser Trp Ile Arg Gln Ser Pro Gly Lys Gly Leu Glu 
        35                  40                  45              


Trp Leu Gly Tyr Ile His His Ser Gly Asn Thr Tyr Tyr Asn Pro Ser 
    50                  55                  60                  


Leu Lys Ser Arg Leu Thr Ile Ser Leu Asp Met Ser Lys Asn Gln Phe 
65                  70                  75                  80  


Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr 
                85                  90                  95      


Cys Ala Arg Asp Leu Gly Lys Pro Leu Trp Asp Gly His Tyr Tyr Tyr 
            100                 105                 110         


Gly Val Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120                 125         


<210> 515
<211> 11
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H1"

<400> 515
Arg Phe Leu Asn Ser Gly Asp Tyr Tyr Trp Ser 
1               5                   10      


<210> 516
<211> 33
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H1"

<400> 516
cgcttcctca atagtggtga ttactactgg agt                                    33


<210> 517
<211> 16
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H2"

<400> 517
Tyr Ile His His Ser Gly Asn Thr Tyr Tyr Asn Pro Ser Leu Lys Ser 
1               5                   10                  15      


<210> 518
<211> 48
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H2"

<400> 518
tacatccatc acagtgggaa cacctactac aacccgtccc tcaagagt                    48


<210> 519
<211> 19
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H3"

<400> 519
Ala Arg Asp Leu Gly Lys Pro Leu Trp Asp Gly His Tyr Tyr Tyr Gly 
1               5                   10                  15      


Val Asp Val 
            


<210> 520
<211> 57
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H3"

<400> 520
gccagagatt tgggaaagcc gctttgggac ggccactatt actacggagt ggacgtc          57


<210> 521
<211> 327
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region"

<400> 521
gatattgtga tgactcagtc tccaggcact ctgtctttgt ctccaggaga aagagccacc       60

ctctcctgca ggaccagtca gaatgttaac agcaactact tagcctggta ccagcataaa      120

cctgggcagg ctcccaggct cctcatctat ggtgcatcca gcagggtcac tggcatccca      180

gacaggttca gtggcagtgg gtctgggaca gacttcactc tcaccatcac cagagtggag      240

tctgaagatt ttgcagtgta ttactgtcag gtgtatagta gttcacctcc gatcaccttc      300

ggccagggga ccaaggtgga gatcaaa                                          327


<210> 522
<211> 109
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region"

<400> 522
Asp Ile Val Met Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Thr Ser Gln Asn Val Asn Ser Asn 
            20                  25                  30          


Tyr Leu Ala Trp Tyr Gln His Lys Pro Gly Gln Ala Pro Arg Leu Leu 
        35                  40                  45              


Ile Tyr Gly Ala Ser Ser Arg Val Thr Gly Ile Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Thr Arg Val Glu 
65                  70                  75                  80  


Ser Glu Asp Phe Ala Val Tyr Tyr Cys Gln Val Tyr Ser Ser Ser Pro 
                85                  90                  95      


Pro Ile Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105                 


<210> 523
<211> 12
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L1"

<400> 523
Arg Thr Ser Gln Asn Val Asn Ser Asn Tyr Leu Ala 
1               5                   10          


<210> 524
<211> 36
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L1"

<400> 524
aggaccagtc agaatgttaa cagcaactac ttagcc                                 36


<210> 525
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L2"

<400> 525
Gly Ala Ser Ser Arg Val Thr 
1               5           


<210> 526
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L2"

<400> 526
ggtgcatcca gcagggtcac t                                                 21


<210> 527
<211> 10
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L3"

<400> 527
Gln Val Tyr Ser Ser Ser Pro Pro Ile Thr 
1               5                   10  


<210> 528
<211> 30
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L3"

<400> 528
caggtgtata gtagttcacc tccgatcacc                                        30


<210> 529
<211> 375
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region"

<400> 529
caggtccagc ttgtgcagtc tggggctgag gtgaagaagc ctgggtcctc ggtgaaggtc       60

tcctgcaagg cttctggagg caccttcagc agttatgcta tcagctgggt gcgtcaggcc      120

ccaggacaag ggcttgagtg gatgggagga atcatcccta tgtttgatat agtcgactac      180

gcacagaagt tccagggcag agtcacgatt accgcggacg aatccacgaa cacagcctac      240

atggagctga ccagcctgag atctgaggac acggccgtgt attactgtgc gagaactgcg      300

gctttaggac cacctgggac tatagtgggg tacatggacg tctggggcaa agggaccacg      360

gtcaccgtct cctca                                                       375


<210> 530
<211> 125
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region"

<400> 530
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Gly Ile Ile Pro Met Phe Asp Ile Val Asp Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Asn Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Thr Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Thr Ala Ala Leu Gly Pro Pro Gly Thr Ile Val Gly Tyr Met 
            100                 105                 110         


Asp Val Trp Gly Lys Gly Thr Thr Val Thr Val Ser Ser 
        115                 120                 125 


<210> 531
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H1"

<400> 531
Gly Thr Phe Ser Ser Tyr Ala Ile Ser 
1               5                   


<210> 532
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H1"

<400> 532
ggcaccttca gcagttatgc tatcagc                                           27


<210> 533
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H2"

<400> 533
Gly Ile Ile Pro Met Phe Asp Ile Val Asp Tyr Ala Gln Lys Phe Gln 
1               5                   10                  15      


Gly 
    


<210> 534
<211> 51
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H2"

<400> 534
ggaatcatcc ctatgtttga tatagtcgac tacgcacaga agttccaggg c                51


<210> 535
<211> 18
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H3"

<400> 535
Ala Arg Thr Ala Ala Leu Gly Pro Pro Gly Thr Ile Val Gly Tyr Met 
1               5                   10                  15      


Asp Val 
        


<210> 536
<211> 54
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H3"

<400> 536
gcgagaactg cggctttagg accacctggg actatagtgg ggtacatgga cgtc             54


<210> 537
<211> 336
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region"

<400> 537
gatattgtga tgacgcagtc tccactctcc ctgcccgtca cccctggaga gccggcctcc       60

atctcctgcc ggtctagtca gagcctcctg caaagtaatg gatacaacta tttggattgg      120

tacctgcaga agccagggca ggctccacag ctcctgatct atttgggttc taatcgggcc      180

tccggggtcc ctgacaagtt cagtggcagt ggatcaggca cagattttac actgaaaatc      240

agcagagtgg aggctgagga tgttggggtt tattactgca tgcaaactct acaaactccg      300

tggacgttcg gccaagggac caaggtggaa atcaaa                                336


<210> 538
<211> 112
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region"

<400> 538
Asp Ile Val Met Thr Gln Ser Pro Leu Ser Leu Pro Val Thr Pro Gly 
1               5                   10                  15      


Glu Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Leu Gln Ser 
            20                  25                  30          


Asn Gly Tyr Asn Tyr Leu Asp Trp Tyr Leu Gln Lys Pro Gly Gln Ala 
        35                  40                  45              


Pro Gln Leu Leu Ile Tyr Leu Gly Ser Asn Arg Ala Ser Gly Val Pro 
    50                  55                  60                  


Asp Lys Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Met Gln Thr 
                85                  90                  95      


Leu Gln Thr Pro Trp Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105                 110         


<210> 539
<211> 16
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L1"

<400> 539
Arg Ser Ser Gln Ser Leu Leu Gln Ser Asn Gly Tyr Asn Tyr Leu Asp 
1               5                   10                  15      


<210> 540
<211> 48
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L1"

<400> 540
cggtctagtc agagcctcct gcaaagtaat ggatacaact atttggat                    48


<210> 541
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L2"

<400> 541
Leu Gly Ser Asn Arg Ala Ser 
1               5           


<210> 542
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L2"

<400> 542
ttgggttcta atcgggcctc c                                                 21


<210> 543
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L3"

<400> 543
Met Gln Thr Leu Gln Thr Pro Trp Thr 
1               5                   


<210> 544
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L3"

<400> 544
atgcaaactc tacaaactcc gtggacg                                           27


<210> 545
<211> 357
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region"

<400> 545
caggtgcagc tggtggagtc tggagcagag gcgagaaagc ccggggagtc tctgaagatc       60

tcctgtaagg cttctggata cagctttacc aattattgga tcggctgggt gcgccagatg      120

cccgggaaag gcctggagtg gatgggggtc atctatcctg ctgactccga taccagatat      180

agcccgtcct tcaaaggcca ggtcaccatc tcagccgaca aatccatcag caccgcctac      240

ctccagtgga ccagactgaa ggcctcggac accgccgtgt atttctgtgc gagacttgga      300

ataggagctg ctgcccggaa ctactggggc cagggaaccc tggtcaccgt ctcttca         357


<210> 546
<211> 119
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region"

<400> 546
Gln Val Gln Leu Val Glu Ser Gly Ala Glu Ala Arg Lys Pro Gly Glu 
1               5                   10                  15      


Ser Leu Lys Ile Ser Cys Lys Ala Ser Gly Tyr Ser Phe Thr Asn Tyr 
            20                  25                  30          


Trp Ile Gly Trp Val Arg Gln Met Pro Gly Lys Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Val Ile Tyr Pro Ala Asp Ser Asp Thr Arg Tyr Ser Pro Ser Phe 
    50                  55                  60                  


Lys Gly Gln Val Thr Ile Ser Ala Asp Lys Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Trp Thr Arg Leu Lys Ala Ser Asp Thr Ala Val Tyr Phe Cys 
                85                  90                  95      


Ala Arg Leu Gly Ile Gly Ala Ala Ala Arg Asn Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210> 547
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H1"

<400> 547
Tyr Ser Phe Thr Asn Tyr Trp Ile Gly 
1               5                   


<210> 548
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H1"

<400> 548
tacagcttta ccaattattg gatcggc                                           27


<210> 549
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H2"

<400> 549
Val Ile Tyr Pro Ala Asp Ser Asp Thr Arg Tyr Ser Pro Ser Phe Lys 
1               5                   10                  15      


Gly 
    


<210> 550
<211> 51
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H2"

<400> 550
gtcatctatc ctgctgactc cgataccaga tatagcccgt ccttcaaagg c                51


<210> 551
<211> 12
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H3"

<400> 551
Ala Arg Leu Gly Ile Gly Ala Ala Ala Arg Asn Tyr 
1               5                   10          


<210> 552
<211> 36
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H3"

<400> 552
gcgagacttg gaataggagc tgctgcccgg aactac                                 36


<210> 553
<211> 321
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region"

<400> 553
gacatccagg tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga cagagtcacc       60

atcacttgcc aggcgagtca ggacattagc gacagtttaa attggtatca gcagaaacca      120

gggaaagccc ctaacctcct gatctacgat gcatccaagt cggaaacagg ggtcccatca      180

agattcagtg gaagcggatc tgggacagat ttcactttca ccatcagtag cctgcagcct      240

gaagatcttg caacatatta ctgtctacag tttgataatc tccctccgac cttcggccaa      300

gggacacgac tggagattaa a                                                321


<210> 554
<211> 107
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region"

<400> 554
Asp Ile Gln Val Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Gln Ala Ser Gln Asp Ile Ser Asp Ser 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Asn Leu Leu Ile 
        35                  40                  45              


Tyr Asp Ala Ser Lys Ser Glu Thr Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Phe Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Leu Ala Thr Tyr Tyr Cys Leu Gln Phe Asp Asn Leu Pro Pro 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Arg Leu Glu Ile Lys 
            100                 105         


<210> 555
<211> 11
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L1"

<400> 555
Gln Ala Ser Gln Asp Ile Ser Asp Ser Leu Asn 
1               5                   10      


<210> 556
<211> 33
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L1"

<400> 556
caggcgagtc aggacattag cgacagttta aat                                    33


<210> 557
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L2"

<400> 557
Asp Ala Ser Lys Ser Glu Thr 
1               5           


<210> 558
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L2"

<400> 558
gatgcatcca agtcggaaac a                                                 21


<210> 559
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L3"

<400> 559
Leu Gln Phe Asp Asn Leu Pro Pro Thr 
1               5                   


<210> 560
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L3"

<400> 560
ctacagtttg ataatctccc tccgacc                                           27


<210> 561
<211> 366
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region"

<400> 561
gaggtgcagc tggtggagtc tgggggaggc ctggtcaagc ctgggggggc cctgagactc       60

tcctgtgcag cctctggatt cagcttcagg agctatagca tgaactgggt ccgccaggct      120

ccagggaagg ggctggagtg ggtctcatcc attagtagta gtagtaatta cataaactac      180

gcagactcag tgaagggccg attcagcatc tccagagaca acgccaagaa ctcactgtat      240

ctgcaaatga acagcctgag agccgaggac acggctgtct attactgtgc gagagatttg      300

ttacccgtcg agcggggtcc cgcttttgat atctggggcc aagggacaat ggtcaccgtc      360

tcttca                                                                 366


<210> 562
<211> 122
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region"

<400> 562
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ala Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ser Phe Arg Ser Tyr 
            20                  25                  30          


Ser Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ser Ile Ser Ser Ser Ser Asn Tyr Ile Asn Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Ser Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Leu Leu Pro Val Glu Arg Gly Pro Ala Phe Asp Ile Trp 
            100                 105                 110         


Gly Gln Gly Thr Met Val Thr Val Ser Ser 
        115                 120         


<210> 563
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H1"

<400> 563
Phe Ser Phe Arg Ser Tyr Ser Met Asn 
1               5                   


<210> 564
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H1"

<400> 564
ttcagcttca ggagctatag catgaac                                           27


<210> 565
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H2"

<400> 565
Ser Ile Ser Ser Ser Ser Asn Tyr Ile Asn Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210> 566
<211> 51
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H2"

<400> 566
tccattagta gtagtagtaa ttacataaac tacgcagact cagtgaaggg c                51


<210> 567
<211> 15
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H3"

<400> 567
Ala Arg Asp Leu Leu Pro Val Glu Arg Gly Pro Ala Phe Asp Ile 
1               5                   10                  15  


<210> 568
<211> 45
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H3"

<400> 568
gcgagagatt tgttacccgt cgagcggggt cccgcttttg atatc                       45


<210> 569
<211> 333
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region"

<400> 569
tcctatgagc tgacacagcc accctcagtg tctggggccc cagggcagag ggtcaccatc       60

tcctgcactg ggagcagctc caacatcggg gcaggttatg atgtacactg gttccagcag      120

cttccaggag cagcccccaa actcctcatc tatgctaaca gcaatcggcc ctcaggggtc      180

cctgaccgat tctctggctc caagtctggc acctcagcct ccctggccat cactgggctc      240

caggctgagg atgaggctga ttattactgc cagtcctatg acagcagact gggtggttcg      300

gtattcggcg gagggaccaa ggtgaccgtc cta                                   333


<210> 570
<211> 111
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region"

<400> 570
Ser Tyr Glu Leu Thr Gln Pro Pro Ser Val Ser Gly Ala Pro Gly Gln 
1               5                   10                  15      


Arg Val Thr Ile Ser Cys Thr Gly Ser Ser Ser Asn Ile Gly Ala Gly 
            20                  25                  30          


Tyr Asp Val His Trp Phe Gln Gln Leu Pro Gly Ala Ala Pro Lys Leu 
        35                  40                  45              


Leu Ile Tyr Ala Asn Ser Asn Arg Pro Ser Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Thr Gly Leu 
65                  70                  75                  80  


Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Gln Ser Tyr Asp Ser Arg 
                85                  90                  95      


Leu Gly Gly Ser Val Phe Gly Gly Gly Thr Lys Val Thr Val Leu 
            100                 105                 110     


<210> 571
<211> 14
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L1"

<400> 571
Thr Gly Ser Ser Ser Asn Ile Gly Ala Gly Tyr Asp Val His 
1               5                   10                  


<210> 572
<211> 42
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L1"

<400> 572
actgggagca gctccaacat cggggcaggt tatgatgtac ac                          42


<210> 573
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L2"

<400> 573
Ala Asn Ser Asn Arg Pro Ser 
1               5           


<210> 574
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L2"

<400> 574
gctaacagca atcggccctc a                                                 21


<210> 575
<211> 11
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L3"

<400> 575
Gln Ser Tyr Asp Ser Arg Leu Gly Gly Ser Val 
1               5                   10      


<210> 576
<211> 33
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L3"

<400> 576
cagtcctatg acagcagact gggtggttcg gta                                    33


<210> 577
<211> 384
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region"

<400> 577
caggtccagc ttgtgcagtc tggaccagag gtgaaaaagc ccggggagtc tctgacgatc       60

tcctgtaagg gttctggata cgacttttcc aataactgga tcggctgggt gcgccagatg      120

cccgggaaag gcctggagtg gatgggaatc atctatcctg gtgactctga taccagatac      180

agcccgtcgt tccaaggcca ggtcaccctc tcagtcgaca agtccattag taccgcctac      240

ctacagtgga ggagcctgaa ggcctcggac agcggcatct actactgtgc gagacaaatt      300

ggcggtttgg tttgtagcag tgagagctgc tacttctacg gcatggacgt ctggggccaa      360

gggaccacgg tcaccgtctc ctca                                             384


<210> 578
<211> 128
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region"

<400> 578
Gln Val Gln Leu Val Gln Ser Gly Pro Glu Val Lys Lys Pro Gly Glu 
1               5                   10                  15      


Ser Leu Thr Ile Ser Cys Lys Gly Ser Gly Tyr Asp Phe Ser Asn Asn 
            20                  25                  30          


Trp Ile Gly Trp Val Arg Gln Met Pro Gly Lys Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Ile Ile Tyr Pro Gly Asp Ser Asp Thr Arg Tyr Ser Pro Ser Phe 
    50                  55                  60                  


Gln Gly Gln Val Thr Leu Ser Val Asp Lys Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Trp Arg Ser Leu Lys Ala Ser Asp Ser Gly Ile Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gln Ile Gly Gly Leu Val Cys Ser Ser Glu Ser Cys Tyr Phe 
            100                 105                 110         


Tyr Gly Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120                 125             


<210> 579
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H1"

<400> 579
Tyr Asp Phe Ser Asn Asn Trp Ile Gly 
1               5                   


<210> 580
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H1"

<400> 580
tacgactttt ccaataactg gatcggc                                           27


<210> 581
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H2"

<400> 581
Ile Ile Tyr Pro Gly Asp Ser Asp Thr Arg Tyr Ser Pro Ser Phe Gln 
1               5                   10                  15      


Gly 
    


<210> 582
<211> 51
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H2"

<400> 582
atcatctatc ctggtgactc tgataccaga tacagcccgt cgttccaagg c                51


<210> 583
<211> 21
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H3"

<400> 583
Ala Arg Gln Ile Gly Gly Leu Val Cys Ser Ser Glu Ser Cys Tyr Phe 
1               5                   10                  15      


Tyr Gly Met Asp Val 
            20      


<210> 584
<211> 63
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H3"

<400> 584
gcgagacaaa ttggcggttt ggtttgtagc agtgagagct gctacttcta cggcatggac       60

gtc                                                                     63


<210> 585
<211> 321
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region"

<400> 585
gacatccagt tgacccagtc tccatcctcc ctgtctgcat ctgtgggagg cagagtgacc       60

atcacttgcc gggcaagtca gagcattagc aactatttaa attggtatca acacaaaccg      120

gggaaagccc ctgaactcct gatctatggt gcatccagtt tgcaaagtgg ggtcccatca      180

aggttcagtg gcagtggatc tgggacagac ttcactctca ccatcagcag tctgcaacct      240

gaagattttg caacttacta ctgtcaacag agtgacacta ccccgttcac tttcggccag      300

gggaccaaag tggatatcaa a                                                321


<210> 586
<211> 107
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region"

<400> 586
Asp Ile Gln Leu Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Gly Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Asn Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln His Lys Pro Gly Lys Ala Pro Glu Leu Leu Ile 
        35                  40                  45              


Tyr Gly Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Asp Thr Thr Pro Phe 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Asp Ile Lys 
            100                 105         


<210> 587
<211> 11
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L1"

<400> 587
Arg Ala Ser Gln Ser Ile Ser Asn Tyr Leu Asn 
1               5                   10      


<210> 588
<211> 33
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L1"

<400> 588
cgggcaagtc agagcattag caactattta aat                                    33


<210> 589
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L2"

<400> 589
Gly Ala Ser Ser Leu Gln Ser 
1               5           


<210> 590
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L2"

<400> 590
ggtgcatcca gtttgcaaag t                                                 21


<210> 591
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L3"

<400> 591
Gln Gln Ser Asp Thr Thr Pro Phe Thr 
1               5                   


<210> 592
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L3"

<400> 592
caacagagtg acactacccc gttcact                                           27


<210> 593
<211> 387
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region"

<400> 593
caggtccagc tggtgcagtc tgggggaggc ttggtaaagc cgggggggtc ccttagactc       60

tcctgtgcag cctctggatt cactttcagt aaggcctgga tgaactgggt ccgccaggct      120

ccagggaagg ggctggagtg ggttggccgt attagaagca aaactgatgg tgggacagca      180

gactacgcgg cacccgtgaa aggcagattc accatgtcaa gagatgattc aaaaaacacg      240

ctgtatttgc aaatgaacag cctgaaaacc gaggacacag ccgtgtatta ctgtgccaca      300

gattctcgcc gactctatga tagtcgtggt ttttattcaa gtgcttttga tgtctggggc      360

caagggacca cggtcaccgt ctcctca                                          387


<210> 594
<211> 129
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region"

<400> 594
Gln Val Gln Leu Val Gln Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Lys Ala 
            20                  25                  30          


Trp Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Gly Arg Ile Arg Ser Lys Thr Asp Gly Gly Thr Ala Asp Tyr Ala Ala 
    50                  55                  60                  


Pro Val Lys Gly Arg Phe Thr Met Ser Arg Asp Asp Ser Lys Asn Thr 
65                  70                  75                  80  


Leu Tyr Leu Gln Met Asn Ser Leu Lys Thr Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Ala Thr Asp Ser Arg Arg Leu Tyr Asp Ser Arg Gly Phe Tyr 
            100                 105                 110         


Ser Ser Ala Phe Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser 
        115                 120                 125             


Ser 
    


<210> 595
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H1"

<400> 595
Phe Thr Phe Ser Lys Ala Trp Met Asn 
1               5                   


<210> 596
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H1"

<400> 596
ttcactttca gtaaggcctg gatgaac                                           27


<210> 597
<211> 19
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H2"

<400> 597
Arg Ile Arg Ser Lys Thr Asp Gly Gly Thr Ala Asp Tyr Ala Ala Pro 
1               5                   10                  15      


Val Lys Gly 
            


<210> 598
<211> 57
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H2"

<400> 598
cgtattagaa gcaaaactga tggtgggaca gcagactacg cggcacccgt gaaaggc          57


<210> 599
<211> 20
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H3"

<400> 599
Ala Thr Asp Ser Arg Arg Leu Tyr Asp Ser Arg Gly Phe Tyr Ser Ser 
1               5                   10                  15      


Ala Phe Asp Val 
            20  


<210> 600
<211> 60
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H3"

<400> 600
gccacagatt ctcgccgact ctatgatagt cgtggttttt attcaagtgc ttttgatgtc       60


<210> 601
<211> 333
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region"

<400> 601
cagtctgtcc tgacgcagcc gccctcagtg tctggggccc cagggcagag ggtcaccatc       60

tcctgcactg ggagcagctc caacatcggg gcgggttatg atgtacactg gtaccaacac      120

cttccaggaa cagcccccaa agtcctcatc tatggtaaca acaatcggcc ctcaggggtc      180

cctgaccgat tctctggctc caagtctggc acctcagcct ccctggccat cactgggctc      240

caggctgagg atgaggctga ttattactgc cagtcctatg acgacagcct gactggttgg      300

gtgttcggcg gagggaccaa ggtcaccgtc cta                                   333


<210> 602
<211> 111
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region"

<400> 602
Gln Ser Val Leu Thr Gln Pro Pro Ser Val Ser Gly Ala Pro Gly Gln 
1               5                   10                  15      


Arg Val Thr Ile Ser Cys Thr Gly Ser Ser Ser Asn Ile Gly Ala Gly 
            20                  25                  30          


Tyr Asp Val His Trp Tyr Gln His Leu Pro Gly Thr Ala Pro Lys Val 
        35                  40                  45              


Leu Ile Tyr Gly Asn Asn Asn Arg Pro Ser Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Thr Gly Leu 
65                  70                  75                  80  


Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Gln Ser Tyr Asp Asp Ser 
                85                  90                  95      


Leu Thr Gly Trp Val Phe Gly Gly Gly Thr Lys Val Thr Val Leu 
            100                 105                 110     


<210> 603
<211> 14
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L1"

<400> 603
Thr Gly Ser Ser Ser Asn Ile Gly Ala Gly Tyr Asp Val His 
1               5                   10                  


<210> 604
<211> 42
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L1"

<400> 604
actgggagca gctccaacat cggggcgggt tatgatgtac ac                          42


<210> 605
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L2"

<400> 605
Gly Asn Asn Asn Arg Pro Ser 
1               5           


<210> 606
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L2"

<400> 606
ggtaacaaca atcggccctc a                                                 21


<210> 607
<211> 11
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L3"

<400> 607
Gln Ser Tyr Asp Asp Ser Leu Thr Gly Trp Val 
1               5                   10      


<210> 608
<211> 33
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L3"

<400> 608
cagtcctatg acgacagcct gactggttgg gtg                                    33


<210> 609
<211> 384
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region"

<400> 609
caggtgcagc tggtgcaatc tggaccagag gtgaaaaagc ccggggagtc tctgacgatc       60

tcctgtaagg gttctggata cgacttttcc aataactgga tcggctgggt gcgccagatg      120

cccgggaaag gcctggagtg gatgggaatc atctatcctg gtgactctga taccagatac      180

agcccgtcgt tccaaggcca ggtcaccctc tcagtcgaca agtccattag taccgcctac      240

ctacagtgga ggagcctgaa ggcctcggac agcggcatct actactgtgc gagacaaatt      300

ggcggtttgg tttgtagcag tgagagctgc tacttctacg gcatggacgt ctggggccaa      360

gggaccacgg tcaccgtctc ctca                                             384


<210> 610
<211> 128
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region"

<400> 610
Gln Val Gln Leu Val Gln Ser Gly Pro Glu Val Lys Lys Pro Gly Glu 
1               5                   10                  15      


Ser Leu Thr Ile Ser Cys Lys Gly Ser Gly Tyr Asp Phe Ser Asn Asn 
            20                  25                  30          


Trp Ile Gly Trp Val Arg Gln Met Pro Gly Lys Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Ile Ile Tyr Pro Gly Asp Ser Asp Thr Arg Tyr Ser Pro Ser Phe 
    50                  55                  60                  


Gln Gly Gln Val Thr Leu Ser Val Asp Lys Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Trp Arg Ser Leu Lys Ala Ser Asp Ser Gly Ile Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gln Ile Gly Gly Leu Val Cys Ser Ser Glu Ser Cys Tyr Phe 
            100                 105                 110         


Tyr Gly Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120                 125             


<210> 611
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H1"

<400> 611
Tyr Asp Phe Ser Asn Asn Trp Ile Gly 
1               5                   


<210> 612
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H1"

<400> 612
tacgactttt ccaataactg gatcggc                                           27


<210> 613
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H2"

<400> 613
Ile Ile Tyr Pro Gly Asp Ser Asp Thr Arg Tyr Ser Pro Ser Phe Gln 
1               5                   10                  15      


Gly 
    


<210> 614
<211> 51
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H2"

<400> 614
atcatctatc ctggtgactc tgataccaga tacagcccgt cgttccaagg c                51


<210> 615
<211> 21
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H3"

<400> 615
Ala Arg Gln Ile Gly Gly Leu Val Cys Ser Ser Glu Ser Cys Tyr Phe 
1               5                   10                  15      


Tyr Gly Met Asp Val 
            20      


<210> 616
<211> 63
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H3"

<400> 616
gcgagacaaa ttggcggttt ggtttgtagc agtgagagct gctacttcta cggcatggac       60

gtc                                                                     63


<210> 617
<211> 321
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region"

<400> 617
gacatccggg tgacccagtc tccatcctcc ctgtctgcat ctgtgggagg cagagtgacc       60

atcacttgcc gggcaagtca gagcattagc aactatttaa attggtatca acacaaaccg      120

gggaaagccc ctgaactcct gatctatggt gcatccagtt tgcaaagtgg ggtcccatca      180

aggttcagtg gcagtggatc tgggacagac ttcactctca ccatcagcag tctgcaacct      240

gaagattttg caacttacta ctgtcaacag agtgacacta ccccgttcac tttcggccag      300

gggaccaagc tggagatcaa a                                                321


<210> 618
<211> 107
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region"

<400> 618
Asp Ile Arg Val Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Gly Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Asn Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln His Lys Pro Gly Lys Ala Pro Glu Leu Leu Ile 
        35                  40                  45              


Tyr Gly Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Asp Thr Thr Pro Phe 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210> 619
<211> 11
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L1"

<400> 619
Arg Ala Ser Gln Ser Ile Ser Asn Tyr Leu Asn 
1               5                   10      


<210> 620
<211> 33
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L1"

<400> 620
cgggcaagtc agagcattag caactattta aat                                    33


<210> 621
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L2"

<400> 621
Gly Ala Ser Ser Leu Gln Ser 
1               5           


<210> 622
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L2"

<400> 622
ggtgcatcca gtttgcaaag t                                                 21


<210> 623
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L3"

<400> 623
Gln Gln Ser Asp Thr Thr Pro Phe Thr 
1               5                   


<210> 624
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L3"

<400> 624
caacagagtg acactacccc gttcact                                           27


<210> 625
<211> 369
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region"

<400> 625
gaggtgcagc tggtggagtc tgggggaggc ctggtcaagc ctggggggtc cctgagactc       60

tcttgtgcag cctctggatt caccttcagt agttttggca tgcattgggt ccgccaggct      120

ccagggcagg gactggagtg ggtcgcatcc attactggtg gcagcagtta cataaactac      180

gcagactcag tgaagggccg attcaccatc tccagagaca acgccaagaa gtcactgtct      240

ctgcaaatga agaacctgag agccgaggac acggctgagt attactgtgt gcgaggagtc      300

ctaccaggtg atactggggg gggctggttc gactcctggg gccagggaac cctggtcacc      360

gtctcctca                                                              369


<210> 626
<211> 123
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region"

<400> 626
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Phe 
            20                  25                  30          


Gly Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Ser Ile Thr Gly Gly Ser Ser Tyr Ile Asn Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Lys Ser Leu Ser 
65                  70                  75                  80  


Leu Gln Met Lys Asn Leu Arg Ala Glu Asp Thr Ala Glu Tyr Tyr Cys 
                85                  90                  95      


Val Arg Gly Val Leu Pro Gly Asp Thr Gly Gly Gly Trp Phe Asp Ser 
            100                 105                 110         


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120             


<210> 627
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H1"

<400> 627
Phe Thr Phe Ser Ser Phe Gly Met His 
1               5                   


<210> 628
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H1"

<400> 628
ttcaccttca gtagttttgg catgcat                                           27


<210> 629
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H2"

<400> 629
Ser Ile Thr Gly Gly Ser Ser Tyr Ile Asn Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210> 630
<211> 51
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H2"

<400> 630
tccattactg gtggcagcag ttacataaac tacgcagact cagtgaaggg c                51


<210> 631
<211> 16
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H3"

<400> 631
Val Arg Gly Val Leu Pro Gly Asp Thr Gly Gly Gly Trp Phe Asp Ser 
1               5                   10                  15      


<210> 632
<211> 48
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H3"

<400> 632
gtgcgaggag tcctaccagg tgatactggg gggggctggt tcgactcc                    48


<210> 633
<211> 330
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region"

<400> 633
cagtctgtgc tgacgcagcc gccctcaatg tctggggccc cagggcagag ggtcaccatc       60

tcctgcactg ggaccagctc caacatcggg gcgggttatg atgtacagtg gtatcagcag      120

tttccaggaa cagcccccaa actcctcatc tctggtaaca acaatcggcc ctcaggggtc      180

cctgaccgat tctctggctc caagtctggc gcctcagcct ccctggccat cactgggctc      240

caggctgagg atgaggctga ttattactgc cagtcctatg actacagcct gaattgggtg      300

ttcggcggag ggaccaagct gaccgtccta                                       330


<210> 634
<211> 110
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region"

<400> 634
Gln Ser Val Leu Thr Gln Pro Pro Ser Met Ser Gly Ala Pro Gly Gln 
1               5                   10                  15      


Arg Val Thr Ile Ser Cys Thr Gly Thr Ser Ser Asn Ile Gly Ala Gly 
            20                  25                  30          


Tyr Asp Val Gln Trp Tyr Gln Gln Phe Pro Gly Thr Ala Pro Lys Leu 
        35                  40                  45              


Leu Ile Ser Gly Asn Asn Asn Arg Pro Ser Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Ala Ser Ala Ser Leu Ala Ile Thr Gly Leu 
65                  70                  75                  80  


Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Gln Ser Tyr Asp Tyr Ser 
                85                  90                  95      


Leu Asn Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 110 


<210> 635
<211> 14
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L1"

<400> 635
Thr Gly Thr Ser Ser Asn Ile Gly Ala Gly Tyr Asp Val Gln 
1               5                   10                  


<210> 636
<211> 42
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L1"

<400> 636
actgggacca gctccaacat cggggcgggt tatgatgtac ag                          42


<210> 637
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L2"

<400> 637
Gly Asn Asn Asn Arg Pro Ser 
1               5           


<210> 638
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L2"

<400> 638
ggtaacaaca atcggccctc a                                                 21


<210> 639
<211> 10
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L3"

<400> 639
Gln Ser Tyr Asp Tyr Ser Leu Asn Trp Val 
1               5                   10  


<210> 640
<211> 30
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L3"

<400> 640
cagtcctatg actacagcct gaattgggtg                                        30


<210> 641
<211> 360
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region"

<400> 641
caggtccagc ttgtacagtc tggagcagag gtgaaaaagc ccggggagtc tctgaagatc       60

tcctgtaagg gttctggata cagctttagc agtttctgga tcggctgggt gcgccagatg      120

cccgggaaag gcctggagtg gatgggcatc atatatcctg gtgactctga taccagatat      180

agcccgtctt tccaaggcca ggtcaccatg tcagccgaca cgtccataaa caccgcctac      240

ctgcagtgga acagcgtgaa ggcctcggac accgccattt attactgtgc gagacttcca      300

gttggtagtt attattactt caatctctgg ggccgtggca ccctggtcac cgtctcctca      360


<210> 642
<211> 120
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region"

<400> 642
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu 
1               5                   10                  15      


Ser Leu Lys Ile Ser Cys Lys Gly Ser Gly Tyr Ser Phe Ser Ser Phe 
            20                  25                  30          


Trp Ile Gly Trp Val Arg Gln Met Pro Gly Lys Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Ile Ile Tyr Pro Gly Asp Ser Asp Thr Arg Tyr Ser Pro Ser Phe 
    50                  55                  60                  


Gln Gly Gln Val Thr Met Ser Ala Asp Thr Ser Ile Asn Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Trp Asn Ser Val Lys Ala Ser Asp Thr Ala Ile Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Leu Pro Val Gly Ser Tyr Tyr Tyr Phe Asn Leu Trp Gly Arg 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser 
        115                 120 


<210> 643
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H1"

<400> 643
Tyr Ser Phe Ser Ser Phe Trp Ile Gly 
1               5                   


<210> 644
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H1"

<400> 644
tacagcttta gcagtttctg gatcggc                                           27


<210> 645
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H2"

<400> 645
Ile Ile Tyr Pro Gly Asp Ser Asp Thr Arg Tyr Ser Pro Ser Phe Gln 
1               5                   10                  15      


Gly 
    


<210> 646
<211> 51
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H2"

<400> 646
atcatatatc ctggtgactc tgataccaga tatagcccgt ctttccaagg c                51


<210> 647
<211> 13
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H3"

<400> 647
Ala Arg Leu Pro Val Gly Ser Tyr Tyr Tyr Phe Asn Leu 
1               5                   10              


<210> 648
<211> 39
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H3"

<400> 648
gcgagacttc cagttggtag ttattattac ttcaatctc                              39


<210> 649
<211> 324
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region"

<400> 649
gaaattgtga tgacacagtc tccagccacc ctgtctgtgt ctccagggga aagcgccacc       60

ctattttgca gggccagtca gagtattagt agcgacttag cctggtacca gcagagacct      120

ggccaggctc ccaggctcct catctatgat gcatccacca gggccactgg tgtccctgcc      180

aggttcagtg ccactgggtc tgaggcagag ttcactctca ccatcagcgg cctgcagtct      240

gaagattttg cagtttatta ctgtcagcag tataataact ggctttcgtg gacgttcggc      300

caagggacca agctggagat caaa                                             324


<210> 650
<211> 108
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region"

<400> 650
Glu Ile Val Met Thr Gln Ser Pro Ala Thr Leu Ser Val Ser Pro Gly 
1               5                   10                  15      


Glu Ser Ala Thr Leu Phe Cys Arg Ala Ser Gln Ser Ile Ser Ser Asp 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Arg Pro Gly Gln Ala Pro Arg Leu Leu Ile 
        35                  40                  45              


Tyr Asp Ala Ser Thr Arg Ala Thr Gly Val Pro Ala Arg Phe Ser Ala 
    50                  55                  60                  


Thr Gly Ser Glu Ala Glu Phe Thr Leu Thr Ile Ser Gly Leu Gln Ser 
65                  70                  75                  80  


Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Asn Asn Trp Leu Ser 
                85                  90                  95      


Trp Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105             


<210> 651
<211> 11
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L1"

<400> 651
Arg Ala Ser Gln Ser Ile Ser Ser Asp Leu Ala 
1               5                   10      


<210> 652
<211> 33
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L1"

<400> 652
agggccagtc agagtattag tagcgactta gcc                                    33


<210> 653
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L2"

<400> 653
Asp Ala Ser Thr Arg Ala Thr 
1               5           


<210> 654
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L2"

<400> 654
gatgcatcca ccagggccac t                                                 21


<210> 655
<211> 10
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L3"

<400> 655
Gln Gln Tyr Asn Asn Trp Leu Ser Trp Thr 
1               5                   10  


<210> 656
<211> 30
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L3"

<400> 656
cagcagtata ataactggct ttcgtggacg                                        30


<210> 657
<211> 360
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region"

<400> 657
caggtgcagc tgcaggagtc gggcccagga ctggagaagc cttcacagac cctgtccctc       60

acctgcactg tctctcgtgg ctccatcaga attggtggtt acttctggag ttggatccgc      120

cagcacccag ggaagggtct ggagtggctt ggatacatct ctaacgatgg ggccaccgac      180

tacaacccgt ccctcaggag tcgacttgcc atatcagcag acacatctaa gaaccagttt      240

tccctgaccc tgaggtctgt gactgccgcg gacacggcca tctattactg tgcgagaact      300

tcttatgcag ggcgcatgct cgaccgctgg ggccagggaa tcctggtcac cgtctcctca      360


<210> 658
<211> 120
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region"

<400> 658
Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Glu Lys Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Arg Gly Ser Ile Arg Ile Gly 
            20                  25                  30          


Gly Tyr Phe Trp Ser Trp Ile Arg Gln His Pro Gly Lys Gly Leu Glu 
        35                  40                  45              


Trp Leu Gly Tyr Ile Ser Asn Asp Gly Ala Thr Asp Tyr Asn Pro Ser 
    50                  55                  60                  


Leu Arg Ser Arg Leu Ala Ile Ser Ala Asp Thr Ser Lys Asn Gln Phe 
65                  70                  75                  80  


Ser Leu Thr Leu Arg Ser Val Thr Ala Ala Asp Thr Ala Ile Tyr Tyr 
                85                  90                  95      


Cys Ala Arg Thr Ser Tyr Ala Gly Arg Met Leu Asp Arg Trp Gly Gln 
            100                 105                 110         


Gly Ile Leu Val Thr Val Ser Ser 
        115                 120 


<210> 659
<211> 11
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H1"

<400> 659
Gly Ser Ile Arg Ile Gly Gly Tyr Phe Trp Ser 
1               5                   10      


<210> 660
<211> 33
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H1"

<400> 660
ggctccatca gaattggtgg ttacttctgg agt                                    33


<210> 661
<211> 16
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H2"

<400> 661
Tyr Ile Ser Asn Asp Gly Ala Thr Asp Tyr Asn Pro Ser Leu Arg Ser 
1               5                   10                  15      


<210> 662
<211> 48
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H2"

<400> 662
tacatctcta acgatggggc caccgactac aacccgtccc tcaggagt                    48


<210> 663
<211> 12
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H3"

<400> 663
Ala Arg Thr Ser Tyr Ala Gly Arg Met Leu Asp Arg 
1               5                   10          


<210> 664
<211> 36
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H3"

<400> 664
gcgagaactt cttatgcagg gcgcatgctc gaccgc                                 36


<210> 665
<211> 336
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region"

<400> 665
gacatccggg tgacccagtc tccagtctcc ctgcccgtca cccctggaga gccggcctcc       60

atctcctgca ggtctagtca gagtctcctg catagtaatg gaaacaacta tttggattgg      120

tacctgcaga agccagggca gtctccacaa ctcctgatct atatgggttc ttatcgggcc      180

tccggggtcc ctgacaggtt cagcggcagt ggatcaggca cagattttac actgaaaatc      240

agcagagtgg aggctgagga tgttggtgtt tattactgca tgcaaggtct acaaattcct      300

tggacgttcg gccaagggac caagctggag atcaaa                                336


<210> 666
<211> 112
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region"

<400> 666
Asp Ile Arg Val Thr Gln Ser Pro Val Ser Leu Pro Val Thr Pro Gly 
1               5                   10                  15      


Glu Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Leu His Ser 
            20                  25                  30          


Asn Gly Asn Asn Tyr Leu Asp Trp Tyr Leu Gln Lys Pro Gly Gln Ser 
        35                  40                  45              


Pro Gln Leu Leu Ile Tyr Met Gly Ser Tyr Arg Ala Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Met Gln Gly 
                85                  90                  95      


Leu Gln Ile Pro Trp Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


<210> 667
<211> 16
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L1"

<400> 667
Arg Ser Ser Gln Ser Leu Leu His Ser Asn Gly Asn Asn Tyr Leu Asp 
1               5                   10                  15      


<210> 668
<211> 48
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L1"

<400> 668
aggtctagtc agagtctcct gcatagtaat ggaaacaact atttggat                    48


<210> 669
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L2"

<400> 669
Met Gly Ser Tyr Arg Ala Ser 
1               5           


<210> 670
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L2"

<400> 670
atgggttctt atcgggcctc c                                                 21


<210> 671
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L3"

<400> 671
Met Gln Gly Leu Gln Ile Pro Trp Thr 
1               5                   


<210> 672
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L3"

<400> 672
atgcaaggtc tacaaattcc ttggacg                                           27


<210> 673
<211> 378
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region"

<400> 673
gaggtgcagc tgttggagtc tgggggaggc gtggtccagc ctgggaggtc cctcagactc       60

tcctgtgcag cctctggatt caccttcagt agctatgcca tgcactgggt ccgccagact      120

ccagacaagg ggctggagtg ggtggcactt atatccgatg atggaagaaa tgaatattat      180

gcagattccg tgcagggccg attcaccatc tccagagaca aatccaagaa cacgctgcat      240

ctggaaatga acagcctgag agctgaggac acggctgttt attactgtgc gaaagtacga      300

aatgaggcgt gggagctcct gggtaatgat gatgctcttg atgtctgggg ccaagggaca      360

atggtcaccg tctcttca                                                    378


<210> 674
<211> 126
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region"

<400> 674
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Met His Trp Val Arg Gln Thr Pro Asp Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Leu Ile Ser Asp Asp Gly Arg Asn Glu Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Gln Gly Arg Phe Thr Ile Ser Arg Asp Lys Ser Lys Asn Thr Leu His 
65                  70                  75                  80  


Leu Glu Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Val Arg Asn Glu Ala Trp Glu Leu Leu Gly Asn Asp Asp Ala 
            100                 105                 110         


Leu Asp Val Trp Gly Gln Gly Thr Met Val Thr Val Ser Ser 
        115                 120                 125     


<210> 675
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H1"

<400> 675
Phe Thr Phe Ser Ser Tyr Ala Met His 
1               5                   


<210> 676
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H1"

<400> 676
ttcaccttca gtagctatgc catgcac                                           27


<210> 677
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H2"

<400> 677
Leu Ile Ser Asp Asp Gly Arg Asn Glu Tyr Tyr Ala Asp Ser Val Gln 
1               5                   10                  15      


Gly 
    


<210> 678
<211> 51
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H2"

<400> 678
cttatatccg atgatggaag aaatgaatat tatgcagatt ccgtgcaggg c                51


<210> 679
<211> 19
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H3"

<400> 679
Ala Lys Val Arg Asn Glu Ala Trp Glu Leu Leu Gly Asn Asp Asp Ala 
1               5                   10                  15      


Leu Asp Val 
            


<210> 680
<211> 57
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H3"

<400> 680
gcgaaagtac gaaatgaggc gtgggagctc ctgggtaatg atgatgctct tgatgtc          57


<210> 681
<211> 330
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region"

<400> 681
cagtctgtgc tgacgcagcc gccctcagtg tctgcggccc caggacagaa agtcaccatc       60

tcctgctctg gaactagctt caacattggc agtaattacg tatcctggta ccagctactc      120

ccaggaacag cccccaaact cctcattttt gacaattata agcgaccctc agggattcct      180

gaccgattct ctggctcctg gtctggcacg tcagccaccc tggccatcag cggactccag      240

actggggacg aggccgaata cttctgcgga acttgggaca ccagcctgag agctggagtg      300

ttcggcggag ggaccaagct caccgtccta                                       330


<210> 682
<211> 110
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region"

<400> 682
Gln Ser Val Leu Thr Gln Pro Pro Ser Val Ser Ala Ala Pro Gly Gln 
1               5                   10                  15      


Lys Val Thr Ile Ser Cys Ser Gly Thr Ser Phe Asn Ile Gly Ser Asn 
            20                  25                  30          


Tyr Val Ser Trp Tyr Gln Leu Leu Pro Gly Thr Ala Pro Lys Leu Leu 
        35                  40                  45              


Ile Phe Asp Asn Tyr Lys Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Trp Ser Gly Thr Ser Ala Thr Leu Ala Ile Ser Gly Leu Gln 
65                  70                  75                  80  


Thr Gly Asp Glu Ala Glu Tyr Phe Cys Gly Thr Trp Asp Thr Ser Leu 
                85                  90                  95      


Arg Ala Gly Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 110 


<210> 683
<211> 13
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L1"

<400> 683
Ser Gly Thr Ser Phe Asn Ile Gly Ser Asn Tyr Val Ser 
1               5                   10              


<210> 684
<211> 39
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L1"

<400> 684
tctggaacta gcttcaacat tggcagtaat tacgtatcc                              39


<210> 685
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L2"

<400> 685
Asp Asn Tyr Lys Arg Pro Ser 
1               5           


<210> 686
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L2"

<400> 686
gacaattata agcgaccctc a                                                 21


<210> 687
<211> 11
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L3"

<400> 687
Gly Thr Trp Asp Thr Ser Leu Arg Ala Gly Val 
1               5                   10      


<210> 688
<211> 33
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L3"

<400> 688
ggaacttggg acaccagcct gagagctgga gtg                                    33


<210> 689
<211> 354
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region"

<400> 689
caggtccagc tggtgcagtc tgggtctgag gtgaagaagc ctggggcctc agtgaggctc       60

tcctgcaagg ttgccggtta cagcctcagt gagttatcca tgcactgggt gcgacagtct      120

cctggaaaag ggcttgagtg gttgggagct tttgaccatg aagatgctga agcaatctat      180

gcaccgaggt tccagggcag aatcaccatg accgcggaca catctacgga cacagcctac      240

atggaactga gcagcctgag atctgaggac acggccgttt attactgtgc aacaccgacc      300

ccagttggag ctacggacta ctggggccag ggaaccctgg tcaccgtctc ctca            354


<210> 690
<211> 118
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region"

<400> 690
Gln Val Gln Leu Val Gln Ser Gly Ser Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Arg Leu Ser Cys Lys Val Ala Gly Tyr Ser Leu Ser Glu Leu 
            20                  25                  30          


Ser Met His Trp Val Arg Gln Ser Pro Gly Lys Gly Leu Glu Trp Leu 
        35                  40                  45              


Gly Ala Phe Asp His Glu Asp Ala Glu Ala Ile Tyr Ala Pro Arg Phe 
    50                  55                  60                  


Gln Gly Arg Ile Thr Met Thr Ala Asp Thr Ser Thr Asp Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Thr Pro Thr Pro Val Gly Ala Thr Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser 
        115             


<210> 691
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H1"

<400> 691
Tyr Ser Leu Ser Glu Leu Ser Met His 
1               5                   


<210> 692
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H1"

<400> 692
tacagcctca gtgagttatc catgcac                                           27


<210> 693
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H2"

<400> 693
Ala Phe Asp His Glu Asp Ala Glu Ala Ile Tyr Ala Pro Arg Phe Gln 
1               5                   10                  15      


Gly 
    


<210> 694
<211> 51
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H2"

<400> 694
gcttttgacc atgaagatgc tgaagcaatc tatgcaccga ggttccaggg c                51


<210> 695
<211> 11
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H3"

<400> 695
Ala Thr Pro Thr Pro Val Gly Ala Thr Asp Tyr 
1               5                   10      


<210> 696
<211> 33
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H3"

<400> 696
gcaacaccga ccccagttgg agctacggac tac                                    33


<210> 697
<211> 321
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region"

<400> 697
gacatccaga tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga cagagtcacc       60

atcacttgcc gggcaagtca gagtattagt agttatttaa attggtatca acaaaaacca      120

ggaaaagccc ctaagctcct gatctatgct gcatccagtt tgcaaagggg gggcccatca      180

agattcagtg gcagtggatc tgggacagat ttcactctca ccatcagcag tctgcaacct      240

gaagattttg caacttacta ttgtcaacag agttacatta ttccgtacac ttttggccag      300

gggaccaaag tggatatcaa a                                                321


<210> 698
<211> 107
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region"

<400> 698
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Ser Leu Gln Arg Gly Gly Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Tyr Ile Ile Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Asp Ile Lys 
            100                 105         


<210> 699
<211> 11
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L1"

<400> 699
Arg Ala Ser Gln Ser Ile Ser Ser Tyr Leu Asn 
1               5                   10      


<210> 700
<211> 33
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L1"

<400> 700
cgggcaagtc agagtattag tagttattta aat                                    33


<210> 701
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L2"

<400> 701
Ala Ala Ser Ser Leu Gln Arg 
1               5           


<210> 702
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L2"

<400> 702
gctgcatcca gtttgcaaag g                                                 21


<210> 703
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L3"

<400> 703
Gln Gln Ser Tyr Ile Ile Pro Tyr Thr 
1               5                   


<210> 704
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L3"

<400> 704
caacagagtt acattattcc gtacact                                           27


<210> 705
<211> 360
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region"

<400> 705
caggtgcagc tgcaggagtc cggcccagga cgggtgaagc cttcggagac cctgtccctc       60

acctgcagtg tcgctgatgg ctcaatcagt agtggtcatt actactgggg ctgggtccgc      120

cagcccccag ggaaggggct ggagtggatt gcgacaatcc atgatagtgg ggccacgtac      180

tacaacccgt ccctccagag tcgagtcacc atatccgtag acacgtccaa gaaccagttc      240

tccctgaaag tgaattctgt gaccgccgca gacacggctg tctattactg tgcgagtcga      300

aggggcagtg gctggttttt cgactcctgg ggccagggaa ccctggtcac cgtctcctca      360


<210> 706
<211> 120
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region"

<400> 706
Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Arg Val Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Ser Val Ala Asp Gly Ser Ile Ser Ser Gly 
            20                  25                  30          


His Tyr Tyr Trp Gly Trp Val Arg Gln Pro Pro Gly Lys Gly Leu Glu 
        35                  40                  45              


Trp Ile Ala Thr Ile His Asp Ser Gly Ala Thr Tyr Tyr Asn Pro Ser 
    50                  55                  60                  


Leu Gln Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe 
65                  70                  75                  80  


Ser Leu Lys Val Asn Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr 
                85                  90                  95      


Cys Ala Ser Arg Arg Gly Ser Gly Trp Phe Phe Asp Ser Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser 
        115                 120 


<210> 707
<211> 11
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H1"

<400> 707
Gly Ser Ile Ser Ser Gly His Tyr Tyr Trp Gly 
1               5                   10      


<210> 708
<211> 33
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H1"

<400> 708
ggctcaatca gtagtggtca ttactactgg ggc                                    33


<210> 709
<211> 16
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H2"

<400> 709
Thr Ile His Asp Ser Gly Ala Thr Tyr Tyr Asn Pro Ser Leu Gln Ser 
1               5                   10                  15      


<210> 710
<211> 48
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H2"

<400> 710
acaatccatg atagtggggc cacgtactac aacccgtccc tccagagt                    48


<210> 711
<211> 12
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H3"

<400> 711
Ala Ser Arg Arg Gly Ser Gly Trp Phe Phe Asp Ser 
1               5                   10          


<210> 712
<211> 36
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H3"

<400> 712
gcgagtcgaa ggggcagtgg ctggtttttc gactcc                                 36


<210> 713
<211> 327
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region"

<400> 713
gatattgtgc tgactcagtc tccagccacc ctgtctgtgt ctccagggga aagagtcacc       60

ctctcctgca gggccagtca cagtgttaac tacaatttag cctggtacca gcagaaacct      120

ggtcaggctc ccaggctcct catctatggt tcatctacca gggccactgg tctcccagcc      180

aggttcagtg gcagtgggtc tgggacagag ttcactctca ccatcagcag cctgcagtct      240

gaagattttg caatttatta ctgtcagcag tataataact ggcctccggg aggcactttt      300

ggccagggga ccaaggtgga aatcaaa                                          327


<210> 714
<211> 109
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region"

<400> 714
Asp Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Val Ser Pro Gly 
1               5                   10                  15      


Glu Arg Val Thr Leu Ser Cys Arg Ala Ser His Ser Val Asn Tyr Asn 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 
        35                  40                  45              


Tyr Gly Ser Ser Thr Arg Ala Thr Gly Leu Pro Ala Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Ser 
65                  70                  75                  80  


Glu Asp Phe Ala Ile Tyr Tyr Cys Gln Gln Tyr Asn Asn Trp Pro Pro 
                85                  90                  95      


Gly Gly Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105                 


<210> 715
<211> 11
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L1"

<400> 715
Arg Ala Ser His Ser Val Asn Tyr Asn Leu Ala 
1               5                   10      


<210> 716
<211> 33
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L1"

<400> 716
agggccagtc acagtgttaa ctacaattta gcc                                    33


<210> 717
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L2"

<400> 717
Gly Ser Ser Thr Arg Ala Thr 
1               5           


<210> 718
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L2"

<400> 718
ggttcatcta ccagggccac t                                                 21


<210> 719
<211> 11
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L3"

<400> 719
Gln Gln Tyr Asn Asn Trp Pro Pro Gly Gly Thr 
1               5                   10      


<210> 720
<211> 33
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L3"

<400> 720
cagcagtata ataactggcc tccgggaggc act                                    33


<210> 721
<211> 369
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region"

<400> 721
gaggtgcagc tgttggagtc tgggggaggc ctggtcaagc ctggggggtc cctgagactc       60

tcctgtgcag cctctggatt caccttcagt agctatagca tgaactgggt ccgccaggct      120

ccagggaagg ggctggagtg ggtctcatcc attagtagta gtagtagtta catatactac      180

gcagactcag tgaagggccg attcaccatc tccagagaca acgccaagaa ctcactgtat      240

ctgcaaatga acagcctgag agccgaggac acggctgtgt attactgtgc gagagattgg      300

ccgaatagca gctcgtcgcc gaactggttc gacccctggg gccagggaac cctggtcacc      360

gtctcctca                                                              369


<210> 722
<211> 123
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region"

<400> 722
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ser Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ser Ile Ser Ser Ser Ser Ser Tyr Ile Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Trp Pro Asn Ser Ser Ser Ser Pro Asn Trp Phe Asp Pro 
            100                 105                 110         


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120             


<210> 723
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H1"

<400> 723
Phe Thr Phe Ser Ser Tyr Ser Met Asn 
1               5                   


<210> 724
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H1"

<400> 724
ttcaccttca gtagctatag catgaac                                           27


<210> 725
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H2"

<400> 725
Ser Ile Ser Ser Ser Ser Ser Tyr Ile Tyr Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210> 726
<211> 51
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H2"

<400> 726
tccattagta gtagtagtag ttacatatac tacgcagact cagtgaaggg c                51


<210> 727
<211> 16
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H3"

<400> 727
Ala Arg Asp Trp Pro Asn Ser Ser Ser Ser Pro Asn Trp Phe Asp Pro 
1               5                   10                  15      


<210> 728
<211> 48
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H3"

<400> 728
gcgagagatt ggccgaatag cagctcgtcg ccgaactggt tcgacccc                    48


<210> 729
<211> 336
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region"

<400> 729
cagtctgtcc tgacgcagcc gccctcagtg tctggggccc cagggcagag ggtcaccatc       60

tcctgcactg ggagcagctc caacatcggg gcaggttatg atgtacactg gtaccagcag      120

cttccaggaa cagcccccaa actcctcatc tatggtaaca gcaatcggcc ctcaggggtc      180

cctgaccgat tctctggctc caagtctggc acctcagcct ccctggccat cactgggctc      240

caggctgagg atgaggctga ttattactgc cagtcctatg acagcagcct gagtggtttt      300

tatgtcttcg gaactgggac caagctcacc gtccta                                336


<210> 730
<211> 112
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region"

<400> 730
Gln Ser Val Leu Thr Gln Pro Pro Ser Val Ser Gly Ala Pro Gly Gln 
1               5                   10                  15      


Arg Val Thr Ile Ser Cys Thr Gly Ser Ser Ser Asn Ile Gly Ala Gly 
            20                  25                  30          


Tyr Asp Val His Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu 
        35                  40                  45              


Leu Ile Tyr Gly Asn Ser Asn Arg Pro Ser Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Thr Gly Leu 
65                  70                  75                  80  


Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Gln Ser Tyr Asp Ser Ser 
                85                  90                  95      


Leu Ser Gly Phe Tyr Val Phe Gly Thr Gly Thr Lys Leu Thr Val Leu 
            100                 105                 110         


<210> 731
<211> 14
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L1"

<400> 731
Thr Gly Ser Ser Ser Asn Ile Gly Ala Gly Tyr Asp Val His 
1               5                   10                  


<210> 732
<211> 42
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L1"

<400> 732
actgggagca gctccaacat cggggcaggt tatgatgtac ac                          42


<210> 733
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L2"

<400> 733
Gly Asn Ser Asn Arg Pro Ser 
1               5           


<210> 734
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L2"

<400> 734
ggtaacagca atcggccctc a                                                 21


<210> 735
<211> 12
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L3"

<400> 735
Gln Ser Tyr Asp Ser Ser Leu Ser Gly Phe Tyr Val 
1               5                   10          


<210> 736
<211> 36
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L3"

<400> 736
cagtcctatg acagcagcct gagtggtttt tatgtc                                 36


<210> 737
<211> 363
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region"

<400> 737
caggtccagc tggtacagtc tggggcagag gtgaaaaagc ccggggagtc tctgaagatc       60

tcctgtcagg gttctggata cagctttagc agtttctgga tcgtctgggt gcgccagatg      120

cccgggaaag gcctggagtg gatggggagc atctatcctg gtgactctga caccagatac      180

accccgtcct tccaaggcca ggtcaccatc tcagccgaca agtccaccag caccgcctat      240

ttgcagtgga acagcctgaa gccctcggac accgccatgt attactgtgc gaggtgtagt      300

ctcagctgcg actactacgg agtgaacctc tggggccaag ggaccacggt caccgtctcc      360

tca                                                                    363


<210> 738
<211> 121
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region"

<400> 738
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu 
1               5                   10                  15      


Ser Leu Lys Ile Ser Cys Gln Gly Ser Gly Tyr Ser Phe Ser Ser Phe 
            20                  25                  30          


Trp Ile Val Trp Val Arg Gln Met Pro Gly Lys Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Ser Ile Tyr Pro Gly Asp Ser Asp Thr Arg Tyr Thr Pro Ser Phe 
    50                  55                  60                  


Gln Gly Gln Val Thr Ile Ser Ala Asp Lys Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Trp Asn Ser Leu Lys Pro Ser Asp Thr Ala Met Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Cys Ser Leu Ser Cys Asp Tyr Tyr Gly Val Asn Leu Trp Gly 
            100                 105                 110         


Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120     


<210> 739
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H1"

<400> 739
Tyr Ser Phe Ser Ser Phe Trp Ile Val 
1               5                   


<210> 740
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H1"

<400> 740
tacagcttta gcagtttctg gatcgtc                                           27


<210> 741
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H2"

<400> 741
Ser Ile Tyr Pro Gly Asp Ser Asp Thr Arg Tyr Thr Pro Ser Phe Gln 
1               5                   10                  15      


Gly 
    


<210> 742
<211> 51
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H2"

<400> 742
agcatctatc ctggtgactc tgacaccaga tacaccccgt ccttccaagg c                51


<210> 743
<211> 14
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H3"

<400> 743
Ala Arg Cys Ser Leu Ser Cys Asp Tyr Tyr Gly Val Asn Leu 
1               5                   10                  


<210> 744
<211> 42
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H3"

<400> 744
gcgaggtgta gtctcagctg cgactactac ggagtgaacc tc                          42


<210> 745
<211> 336
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region"

<400> 745
cagtctgtgg tgacgcagcc gccctcagtg tctggggccc caggacagag ggtcaccatc       60

tcctgctctg ggagcagctc caacatcggg gcacgttctg atgtacactg gtaccagcag      120

cttccaggaa aagcccccaa actcctcatc tatggtaaca ccaatcggcc cttaggggtc      180

cctgaccgat tctctggctc cacgtctggc acctcagcct ccctggccat ctctgggctc      240

caggctgagg atgagggata ttattactgt cagtcctatg acagcagcct gagtggtttt      300

tatgtcttcg gaactgggac caagctcacc gtccta                                336


<210> 746
<211> 112
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region"

<400> 746
Gln Ser Val Val Thr Gln Pro Pro Ser Val Ser Gly Ala Pro Gly Gln 
1               5                   10                  15      


Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Ala Arg 
            20                  25                  30          


Ser Asp Val His Trp Tyr Gln Gln Leu Pro Gly Lys Ala Pro Lys Leu 
        35                  40                  45              


Leu Ile Tyr Gly Asn Thr Asn Arg Pro Leu Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Thr Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu 
65                  70                  75                  80  


Gln Ala Glu Asp Glu Gly Tyr Tyr Tyr Cys Gln Ser Tyr Asp Ser Ser 
                85                  90                  95      


Leu Ser Gly Phe Tyr Val Phe Gly Thr Gly Thr Lys Leu Thr Val Leu 
            100                 105                 110         


<210> 747
<211> 14
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L1"

<400> 747
Ser Gly Ser Ser Ser Asn Ile Gly Ala Arg Ser Asp Val His 
1               5                   10                  


<210> 748
<211> 42
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L1"

<400> 748
tctgggagca gctccaacat cggggcacgt tctgatgtac ac                          42


<210> 749
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L2"

<400> 749
Gly Asn Thr Asn Arg Pro Leu 
1               5           


<210> 750
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L2"

<400> 750
ggtaacacca atcggccctt a                                                 21


<210> 751
<211> 12
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L3"

<400> 751
Gln Ser Tyr Asp Ser Ser Leu Ser Gly Phe Tyr Val 
1               5                   10          


<210> 752
<211> 36
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L3"

<400> 752
cagtcctatg acagcagcct gagtggtttt tatgtc                                 36


<210> 753
<211> 363
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region"

<400> 753
caggtgcagc tggtggaatc tgggggaggc gtggtccagc ctgggaggtc cctgagactc       60

tcctgtgcag cctctggatt ccccttcagt ctctatgcca tgcactgggt ccgccaggct      120

ccaggcaagg ggctggagtg ggtggcattt atatcatatg atggaagtaa taaatactat      180

gcagactccg tgaagggccg attcaccatc tccagagaca gttccaagaa cacgctgtat      240

ctgcaaatgg acagcctgac acctgaagac acggctgtgt attactgtgc gaaacctata      300

gtggggccta caacgggtta ctttgactac tggggcccgg gaaccctggt caccgtctcc      360

tca                                                                    363


<210> 754
<211> 121
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region"

<400> 754
Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Pro Phe Ser Leu Tyr 
            20                  25                  30          


Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Phe Ile Ser Tyr Asp Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Ser Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asp Ser Leu Thr Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Pro Ile Val Gly Pro Thr Thr Gly Tyr Phe Asp Tyr Trp Gly 
            100                 105                 110         


Pro Gly Thr Leu Val Thr Val Ser Ser 
        115                 120     


<210> 755
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H1"

<400> 755
Phe Pro Phe Ser Leu Tyr Ala Met His 
1               5                   


<210> 756
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H1"

<400> 756
ttccccttca gtctctatgc catgcac                                           27


<210> 757
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H2"

<400> 757
Phe Ile Ser Tyr Asp Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210> 758
<211> 51
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H2"

<400> 758
tttatatcat atgatggaag taataaatac tatgcagact ccgtgaaggg c                51


<210> 759
<211> 14
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H3"

<400> 759
Ala Lys Pro Ile Val Gly Pro Thr Thr Gly Tyr Phe Asp Tyr 
1               5                   10                  


<210> 760
<211> 42
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H3"

<400> 760
gcgaaaccta tagtggggcc tacaacgggt tactttgact ac                          42


<210> 761
<211> 318
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region"

<400> 761
gaaattgtgt tgactcagtc tccagccacc ctgtctttgt ctccagggga aagagccacc       60

ctctcctgca gggccagtca gagtgttagc agctacttag cctggtacca acagaaacct      120

ggccaggctc ccaggctcct catctatgat gcatccaaca gggccactgg catcccagcc      180

aggttcagtg gcagtgggtc tgggacagac ttcactctca ccatcagcag cctagagcct      240

gaagattttg cagtttatta ctgtcagcag cgtagcaact ggtacacttt tggccagggg      300

accaaggtgg aaatcaaa                                                    318


<210> 762
<211> 106
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region"

<400> 762
Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Tyr 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 
        35                  40                  45              


Tyr Asp Ala Ser Asn Arg Ala Thr Gly Ile Pro Ala Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Arg Ser Asn Trp Tyr Thr 
                85                  90                  95      


Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105     


<210> 763
<211> 11
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L1"

<400> 763
Arg Ala Ser Gln Ser Val Ser Ser Tyr Leu Ala 
1               5                   10      


<210> 764
<211> 33
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L1"

<400> 764
agggccagtc agagtgttag cagctactta gcc                                    33


<210> 765
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L2"

<400> 765
Asp Ala Ser Asn Arg Ala Thr 
1               5           


<210> 766
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L2"

<400> 766
gatgcatcca acagggccac t                                                 21


<210> 767
<211> 8
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L3"

<400> 767
Gln Gln Arg Ser Asn Trp Tyr Thr 
1               5               


<210> 768
<211> 24
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L3"

<400> 768
cagcagcgta gcaactggta cact                                              24


<210> 769
<211> 363
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region"

<400> 769
gaggtgcagc tggtggagtc tggggctgag gtgaagaagc ctggggcctc agtgaaggtc       60

tcctgccaga cttctggtta cacctttagt catttcggtg tcacctggat acgacaggcc      120

ccaggacaag ggcttgagtg gctgggatgg atcagcgctt acaatggtaa cacagactat      180

gcagacaaac tgcagggcag actcaccatg accacagaca catccacgaa caccgcctac      240

atggaattga ggagcctcag atctgacgac acggccgtct attactgtgc gagagatccc      300

cccgcatcag ctgctgcgat gcttgactac tggggccagg gaaccctggt caccgtctcc      360

tca                                                                    363


<210> 770
<211> 121
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region"

<400> 770
Glu Val Gln Leu Val Glu Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Gln Thr Ser Gly Tyr Thr Phe Ser His Phe 
            20                  25                  30          


Gly Val Thr Trp Ile Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Leu 
        35                  40                  45              


Gly Trp Ile Ser Ala Tyr Asn Gly Asn Thr Asp Tyr Ala Asp Lys Leu 
    50                  55                  60                  


Gln Gly Arg Leu Thr Met Thr Thr Asp Thr Ser Thr Asn Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Arg Ser Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Pro Pro Ala Ser Ala Ala Ala Met Leu Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120     


<210> 771
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H1"

<400> 771
Tyr Thr Phe Ser His Phe Gly Val Thr 
1               5                   


<210> 772
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H1"

<400> 772
tacaccttta gtcatttcgg tgtcacc                                           27


<210> 773
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H2"

<400> 773
Trp Ile Ser Ala Tyr Asn Gly Asn Thr Asp Tyr Ala Asp Lys Leu Gln 
1               5                   10                  15      


Gly 
    


<210> 774
<211> 51
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H2"

<400> 774
tggatcagcg cttacaatgg taacacagac tatgcagaca aactgcaggg c                51


<210> 775
<211> 14
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H3"

<400> 775
Ala Arg Asp Pro Pro Ala Ser Ala Ala Ala Met Leu Asp Tyr 
1               5                   10                  


<210> 776
<211> 42
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H3"

<400> 776
gcgagagatc cccccgcatc agctgctgcg atgcttgact ac                          42


<210> 777
<211> 339
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region"

<400> 777
gatattgtga tgactcagtc tccactctcc ctggccgtca cccttggaca gccggcctcc       60

atctcctgca agtctagtca aggcctcgaa tacactgatg gaaacaccta cttgagttgg      120

tttcagcaga ggccaggcca atctccaagg cgcctcattt ataagatttc taaccgggac      180

tctggggttc cagacagatt cagcggcagt gggtcaggca ctgatttcac actgagaatc      240

agcagggtgg aggctgagga tgttggggtt tattactgca tgcaaggtac acacgggcgg      300

ggaatctctt tcggtcctgg gaccaaagtg gatatcaaa                             339


<210> 778
<211> 113
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region"

<400> 778
Asp Ile Val Met Thr Gln Ser Pro Leu Ser Leu Ala Val Thr Leu Gly 
1               5                   10                  15      


Gln Pro Ala Ser Ile Ser Cys Lys Ser Ser Gln Gly Leu Glu Tyr Thr 
            20                  25                  30          


Asp Gly Asn Thr Tyr Leu Ser Trp Phe Gln Gln Arg Pro Gly Gln Ser 
        35                  40                  45              


Pro Arg Arg Leu Ile Tyr Lys Ile Ser Asn Arg Asp Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Arg Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Met Gln Gly 
                85                  90                  95      


Thr His Gly Arg Gly Ile Ser Phe Gly Pro Gly Thr Lys Val Asp Ile 
            100                 105                 110         


Lys 
    


<210> 779
<211> 16
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L1"

<400> 779
Lys Ser Ser Gln Gly Leu Glu Tyr Thr Asp Gly Asn Thr Tyr Leu Ser 
1               5                   10                  15      


<210> 780
<211> 48
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L1"

<400> 780
aagtctagtc aaggcctcga atacactgat ggaaacacct acttgagt                    48


<210> 781
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L2"

<400> 781
Lys Ile Ser Asn Arg Asp Ser 
1               5           


<210> 782
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L2"

<400> 782
aagatttcta accgggactc t                                                 21


<210> 783
<211> 10
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L3"

<400> 783
Met Gln Gly Thr His Gly Arg Gly Ile Ser 
1               5                   10  


<210> 784
<211> 30
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L3"

<400> 784
atgcaaggta cacacgggcg gggaatctct                                        30


<210> 785
<211> 363
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region"

<400> 785
caggtgcagc tggtgcagtc tggggctgaa gtgaagaagc ctggggcctc agtgaaggtc       60

tcctgcaagg cttctggata caccttcacc gactacttta tacactgggt gcgccaggcc      120

cctggagaag ggcttgagtg gatgggttgg gtcaaccctc tcagtgacaa cacaaaatat      180

tcacagaagt ttcagggcag ggtcaccatg agcacggaca cgtccatcac cacggcctac      240

atgtacctga gcaggctgcg atttgacgac acggccgtgt atttttgtgc gagccaatct      300

tccccctata ccccgggcgc tctggacgtc tggggccaag ggaccacggt caccgtctcc      360

tca                                                                    363


<210> 786
<211> 121
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region"

<400> 786
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Tyr 
            20                  25                  30          


Phe Ile His Trp Val Arg Gln Ala Pro Gly Glu Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Val Asn Pro Leu Ser Asp Asn Thr Lys Tyr Ser Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Met Ser Thr Asp Thr Ser Ile Thr Thr Ala Tyr 
65                  70                  75                  80  


Met Tyr Leu Ser Arg Leu Arg Phe Asp Asp Thr Ala Val Tyr Phe Cys 
                85                  90                  95      


Ala Ser Gln Ser Ser Pro Tyr Thr Pro Gly Ala Leu Asp Val Trp Gly 
            100                 105                 110         


Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120     


<210> 787
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H1"

<400> 787
Tyr Thr Phe Thr Asp Tyr Phe Ile His 
1               5                   


<210> 788
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H1"

<400> 788
tacaccttca ccgactactt tatacac                                           27


<210> 789
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H2"

<400> 789
Trp Val Asn Pro Leu Ser Asp Asn Thr Lys Tyr Ser Gln Lys Phe Gln 
1               5                   10                  15      


Gly 
    


<210> 790
<211> 51
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H2"

<400> 790
tgggtcaacc ctctcagtga caacacaaaa tattcacaga agtttcaggg c                51


<210> 791
<211> 14
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H3"

<400> 791
Ala Ser Gln Ser Ser Pro Tyr Thr Pro Gly Ala Leu Asp Val 
1               5                   10                  


<210> 792
<211> 42
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H3"

<400> 792
gcgagccaat cttcccccta taccccgggc gctctggacg tc                          42


<210> 793
<211> 321
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region"

<400> 793
gacatccagt tgacccagtc tccatcctcc ctgcctgcat ctgtaggaga cagagtcacc       60

atcacttgcc gggcaagtca gaacattggg aacaatttag cttggtatca gcagaaagca      120

ggaagagccc ccaaactcct gatctatagt gcgtctaatt tccatagtgg ggtcccatca      180

agattcattg gcagtggatc tgggacagtt ttcactctca ccatcagcag tctgcaacct      240

gaagattttg caacctactt ctgtcaacag agtttcactc cccaattcac tttcggccct      300

gggaccaagg tggaaatcaa a                                                321


<210> 794
<211> 107
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region"

<400> 794
Asp Ile Gln Leu Thr Gln Ser Pro Ser Ser Leu Pro Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asn Ile Gly Asn Asn 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Ala Gly Arg Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ser Ala Ser Asn Phe His Ser Gly Val Pro Ser Arg Phe Ile Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Val Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Phe Cys Gln Gln Ser Phe Thr Pro Gln Phe 
                85                  90                  95      


Thr Phe Gly Pro Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210> 795
<211> 11
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L1"

<400> 795
Arg Ala Ser Gln Asn Ile Gly Asn Asn Leu Ala 
1               5                   10      


<210> 796
<211> 33
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L1"

<400> 796
cgggcaagtc agaacattgg gaacaattta gct                                    33


<210> 797
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L2"

<400> 797
Ser Ala Ser Asn Phe His Ser 
1               5           


<210> 798
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L2"

<400> 798
agtgcgtcta atttccatag t                                                 21


<210> 799
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L3"

<400> 799
Gln Gln Ser Phe Thr Pro Gln Phe Thr 
1               5                   


<210> 800
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L3"

<400> 800
caacagagtt tcactcccca attcact                                           27


<210> 801
<211> 384
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region"

<400> 801
caggtccagc tggtgcagtc tggggctgag gtgaagaggc ctgggtcctc ggtgagggtc       60

tcctgcaagg cttctggagg caccttcagg aagtatgcta tcagttgggt gcgacaggcc      120

cgtggacaag ggcttgagtg gatgggaggc atcatcccta tgtccggacc accaagctac      180

gcacagaagt ttcagggcag agtcacgatt accgcggacg aatccacgag cacagtctac      240

atggagctga gcagcctgag atttgaggac acggccgtgt atttctgtgc gagggatatc      300

gagtggttcg tactcatgga ccctatcaca tcctactacc ctatggacgt ctggggccaa      360

gggaccacgg tcaccgtctc ctca                                             384


<210> 802
<211> 128
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region"

<400> 802
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Arg Pro Gly Ser 
1               5                   10                  15      


Ser Val Arg Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Arg Lys Tyr 
            20                  25                  30          


Ala Ile Ser Trp Val Arg Gln Ala Arg Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Gly Ile Ile Pro Met Ser Gly Pro Pro Ser Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Ser Thr Val Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Phe Glu Asp Thr Ala Val Tyr Phe Cys 
                85                  90                  95      


Ala Arg Asp Ile Glu Trp Phe Val Leu Met Asp Pro Ile Thr Ser Tyr 
            100                 105                 110         


Tyr Pro Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120                 125             


<210> 803
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H1"

<400> 803
Gly Thr Phe Arg Lys Tyr Ala Ile Ser 
1               5                   


<210> 804
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H1"

<400> 804
ggcaccttca ggaagtatgc tatcagt                                           27


<210> 805
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H2"

<400> 805
Gly Ile Ile Pro Met Ser Gly Pro Pro Ser Tyr Ala Gln Lys Phe Gln 
1               5                   10                  15      


Gly 
    


<210> 806
<211> 51
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H2"

<400> 806
ggcatcatcc ctatgtccgg accaccaagc tacgcacaga agtttcaggg c                51


<210> 807
<211> 21
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H3"

<400> 807
Ala Arg Asp Ile Glu Trp Phe Val Leu Met Asp Pro Ile Thr Ser Tyr 
1               5                   10                  15      


Tyr Pro Met Asp Val 
            20      


<210> 808
<211> 63
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H3"

<400> 808
gcgagggata tcgagtggtt cgtactcatg gaccctatca catcctacta ccctatggac       60

gtc                                                                     63


<210> 809
<211> 330
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region"

<400> 809
cagtctgtgg tgacccagga gccctcactg actgtgtccc caggagggac agtcactctc       60

acctgtggct ccagcactgg aggtgtcacc agtggtcatc atacatactg gttccagcag      120

aagcctggcc aagcccccag gacactgatc tatgatacga ccaacacaca ctcctggaca      180

ccagcccggt tcgcaggctc cctccttggg ggcaaagctg ccctgaccct ttcgggtgcg      240

cagcctgagg atgaggctga ctattactgc ctcctctcct atagtggtgc gcggccggtg      300

ttcggcggag ggaccaagct gaccgtccta                                       330


<210> 810
<211> 110
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region"

<400> 810
Gln Ser Val Val Thr Gln Glu Pro Ser Leu Thr Val Ser Pro Gly Gly 
1               5                   10                  15      


Thr Val Thr Leu Thr Cys Gly Ser Ser Thr Gly Gly Val Thr Ser Gly 
            20                  25                  30          


His His Thr Tyr Trp Phe Gln Gln Lys Pro Gly Gln Ala Pro Arg Thr 
        35                  40                  45              


Leu Ile Tyr Asp Thr Thr Asn Thr His Ser Trp Thr Pro Ala Arg Phe 
    50                  55                  60                  


Ala Gly Ser Leu Leu Gly Gly Lys Ala Ala Leu Thr Leu Ser Gly Ala 
65                  70                  75                  80  


Gln Pro Glu Asp Glu Ala Asp Tyr Tyr Cys Leu Leu Ser Tyr Ser Gly 
                85                  90                  95      


Ala Arg Pro Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 110 


<210> 811
<211> 14
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L1"

<400> 811
Gly Ser Ser Thr Gly Gly Val Thr Ser Gly His His Thr Tyr 
1               5                   10                  


<210> 812
<211> 42
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L1"

<400> 812
ggctccagca ctggaggtgt caccagtggt catcatacat ac                          42


<210> 813
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L2"

<400> 813
Asp Thr Thr Asn Thr His Ser 
1               5           


<210> 814
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L2"

<400> 814
gatacgacca acacacactc c                                                 21


<210> 815
<211> 10
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L3"

<400> 815
Leu Leu Ser Tyr Ser Gly Ala Arg Pro Val 
1               5                   10  


<210> 816
<211> 30
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L3"

<400> 816
ctcctctcct atagtggtgc gcggccggtg                                        30


<210> 817
<211> 384
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region"

<400> 817
caggtgcagc tggtgcagtc tgggggaggc ttggtcaagc ctggagggtc cctgagactc       60

tcctgtgcag cctctggatt caccttcaat gattactaca tgaattggat ccgccaggct      120

ccagggaagg ggctggaatg ggtttcatac attagtagta gtggtgagac caaatactac      180

gcagactctg tgaagggccg attcaccatc tccagggaca acgccaagaa ctcactgtat      240

ctggaaatga acagcctgag agtcgaggac acggccgtct actactgtgc gagagacgcg      300

gtcattgtag taggaccggt tgctgttcac taccaatact acgcggacgt ctggggcaaa      360

gggaccacgg tcaccgtctc ttca                                             384


<210> 818
<211> 128
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region"

<400> 818
Gln Val Gln Leu Val Gln Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Asp Tyr 
            20                  25                  30          


Tyr Met Asn Trp Ile Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Tyr Ile Ser Ser Ser Gly Glu Thr Lys Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Glu Met Asn Ser Leu Arg Val Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Ala Val Ile Val Val Gly Pro Val Ala Val His Tyr Gln 
            100                 105                 110         


Tyr Tyr Ala Asp Val Trp Gly Lys Gly Thr Thr Val Thr Val Ser Ser 
        115                 120                 125             


<210> 819
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H1"

<400> 819
Phe Thr Phe Asn Asp Tyr Tyr Met Asn 
1               5                   


<210> 820
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H1"

<400> 820
ttcaccttca atgattacta catgaat                                           27


<210> 821
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H2"

<400> 821
Tyr Ile Ser Ser Ser Gly Glu Thr Lys Tyr Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210> 822
<211> 51
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H2"

<400> 822
tacattagta gtagtggtga gaccaaatac tacgcagact ctgtgaaggg c                51


<210> 823
<211> 21
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H3"

<400> 823
Ala Arg Asp Ala Val Ile Val Val Gly Pro Val Ala Val His Tyr Gln 
1               5                   10                  15      


Tyr Tyr Ala Asp Val 
            20      


<210> 824
<211> 63
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H3"

<400> 824
gcgagagacg cggtcattgt agtaggaccg gttgctgttc actaccaata ctacgcggac       60

gtc                                                                     63


<210> 825
<211> 330
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region"

<400> 825
cagccagtgc tgactcagcc accctcagcg tctgggaccc ccgggcagag ggtcaccatc       60

tcttgttctg gaagcacctc caacatcgga agtaacactg tacactggta ccagcaactc      120

ccaggaacgg cccccagact cctcatctat gttattaatc agcggccctc aggggtccca      180

gaccgattct ccggctccaa gtctggcacc tcagcctccc tggccatcag tgggctccag      240

tctgaggatg aggctgatta ttactgtgca gcatgggatg acagcctgaa tggtccggtg      300

ttcggcggag ggaccaagct caccgtccta                                       330


<210> 826
<211> 110
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region"

<400> 826
Gln Pro Val Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln 
1               5                   10                  15      


Arg Val Thr Ile Ser Cys Ser Gly Ser Thr Ser Asn Ile Gly Ser Asn 
            20                  25                  30          


Thr Val His Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Arg Leu Leu 
        35                  40                  45              


Ile Tyr Val Ile Asn Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Gln 
65                  70                  75                  80  


Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Asp Ser Leu 
                85                  90                  95      


Asn Gly Pro Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 110 


<210> 827
<211> 13
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L1"

<400> 827
Ser Gly Ser Thr Ser Asn Ile Gly Ser Asn Thr Val His 
1               5                   10              


<210> 828
<211> 39
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L1"

<400> 828
tctggaagca cctccaacat cggaagtaac actgtacac                              39


<210> 829
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L2"

<400> 829
Val Ile Asn Gln Arg Pro Ser 
1               5           


<210> 830
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L2"

<400> 830
gttattaatc agcggccctc a                                                 21


<210> 831
<211> 11
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L3"

<400> 831
Ala Ala Trp Asp Asp Ser Leu Asn Gly Pro Val 
1               5                   10      


<210> 832
<211> 33
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L3"

<400> 832
gcagcatggg atgacagcct gaatggtccg gtg                                    33


<210> 833
<211> 375
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region"

<400> 833
caggtccagc ttgtgcagtc tggggctgag gtgaagaagc ctgggtcctc ggtgaaggtc       60

tcctgcaagg cctctggagg caccttcagc ggctaccata tcagctgggt gcgacaggcc      120

cctggacaag ggctcgagtg gatgggaggg atcatccatc tatttgggac agttaactac      180

gctccgaagt tccagggcag agtcacgatc accgcggacg catccacggg cacagcctac      240

atggagttaa acagcctgat gtctgaagac acggccgttt attattgtgc gagagatgcc      300

tacgaagtgt ggactggttc ttatctcccc ccttttgact actggggcca gggaaccctg      360

gtcaccgtct cctca                                                       375


<210> 834
<211> 125
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region"

<400> 834
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Gly Tyr 
            20                  25                  30          


His Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Gly Ile Ile His Leu Phe Gly Thr Val Asn Tyr Ala Pro Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Ala Asp Ala Ser Thr Gly Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Asn Ser Leu Met Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Ala Tyr Glu Val Trp Thr Gly Ser Tyr Leu Pro Pro Phe 
            100                 105                 110         


Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125 


<210> 835
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H1"

<400> 835
Gly Thr Phe Ser Gly Tyr His Ile Ser 
1               5                   


<210> 836
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H1"

<400> 836
ggcaccttca gcggctacca tatcagc                                           27


<210> 837
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H2"

<400> 837
Gly Ile Ile His Leu Phe Gly Thr Val Asn Tyr Ala Pro Lys Phe Gln 
1               5                   10                  15      


Gly 
    


<210> 838
<211> 51
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H2"

<400> 838
gggatcatcc atctatttgg gacagttaac tacgctccga agttccaggg c                51


<210> 839
<211> 18
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H3"

<400> 839
Ala Arg Asp Ala Tyr Glu Val Trp Thr Gly Ser Tyr Leu Pro Pro Phe 
1               5                   10                  15      


Asp Tyr 
        


<210> 840
<211> 54
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H3"

<400> 840
gcgagagatg cctacgaagt gtggactggt tcttatctcc ccccttttga ctac             54


<210> 841
<211> 324
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region"

<400> 841
gaaattgtgt tgacacagtc tccaggcacc ctgtctttgt ctcccgggga aagagtcacc       60

ctctcctgca gggccagtca gactgttaca agcagctact tagcctggta ccagcagaaa      120

cctggccagg ctcccaggct cctcatctat ggtgcattca ccagggccac tgacatccca      180

gacaggttca gtggcagtgg gtctgggaca gacttcactc tcaccatcag cagactggag      240

cctgaagatt ctgcagtata ttattgtcag cagtatggta gctcattcct cactttcggc      300

ggagggacca aagtggatat caaa                                             324


<210> 842
<211> 108
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region"

<400> 842
Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Val Thr Leu Ser Cys Arg Ala Ser Gln Thr Val Thr Ser Ser 
            20                  25                  30          


Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu 
        35                  40                  45              


Ile Tyr Gly Ala Phe Thr Arg Ala Thr Asp Ile Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu 
65                  70                  75                  80  


Pro Glu Asp Ser Ala Val Tyr Tyr Cys Gln Gln Tyr Gly Ser Ser Phe 
                85                  90                  95      


Leu Thr Phe Gly Gly Gly Thr Lys Val Asp Ile Lys 
            100                 105             


<210> 843
<211> 12
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L1"

<400> 843
Arg Ala Ser Gln Thr Val Thr Ser Ser Tyr Leu Ala 
1               5                   10          


<210> 844
<211> 36
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L1"

<400> 844
agggccagtc agactgttac aagcagctac ttagcc                                 36


<210> 845
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L2"

<400> 845
Gly Ala Phe Thr Arg Ala Thr 
1               5           


<210> 846
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L2"

<400> 846
ggtgcattca ccagggccac t                                                 21


<210> 847
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L3"

<400> 847
Gln Gln Tyr Gly Ser Ser Phe Leu Thr 
1               5                   


<210> 848
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L3"

<400> 848
cagcagtatg gtagctcatt cctcact                                           27


<210> 849
<211> 387
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region"

<400> 849
gaggtgcagc tggtggagtc tgggggaggc ttgcaaaagc ccgggcggtc cctgcgactc       60

tcatgttcag cttctggatt cacctttggt gattatgcta tgagctggtt ccgccaggct      120

ccagggaagg gcctggagtg ggttggtttc attagaagta aagcttatgt tgggaccgca      180

gaatacgccg cgtctgtgaa aggcagattc accatctcaa gagatgattc caaaagcatc      240

gcctatctgc acatgaacag cctgaagacc gaggacacag ccgtgtatta ctgtactaga      300

gatgatattt tgactggttt ttatgaccgc tcttactatt acggtataca cgtctggggc      360

caagggacca cggtcaccgt ctcctca                                          387


<210> 850
<211> 129
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region"

<400> 850
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Gln Lys Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ser Ala Ser Gly Phe Thr Phe Gly Asp Tyr 
            20                  25                  30          


Ala Met Ser Trp Phe Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Gly Phe Ile Arg Ser Lys Ala Tyr Val Gly Thr Ala Glu Tyr Ala Ala 
    50                  55                  60                  


Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Ser Ile 
65                  70                  75                  80  


Ala Tyr Leu His Met Asn Ser Leu Lys Thr Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Thr Arg Asp Asp Ile Leu Thr Gly Phe Tyr Asp Arg Ser Tyr 
            100                 105                 110         


Tyr Tyr Gly Ile His Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser 
        115                 120                 125             


Ser 
    


<210> 851
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H1"

<400> 851
Phe Thr Phe Gly Asp Tyr Ala Met Ser 
1               5                   


<210> 852
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H1"

<400> 852
ttcacctttg gtgattatgc tatgagc                                           27


<210> 853
<211> 19
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H2"

<400> 853
Phe Ile Arg Ser Lys Ala Tyr Val Gly Thr Ala Glu Tyr Ala Ala Ser 
1               5                   10                  15      


Val Lys Gly 
            


<210> 854
<211> 57
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H2"

<400> 854
ttcattagaa gtaaagctta tgttgggacc gcagaatacg ccgcgtctgt gaaaggc          57


<210> 855
<211> 20
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H3"

<400> 855
Thr Arg Asp Asp Ile Leu Thr Gly Phe Tyr Asp Arg Ser Tyr Tyr Tyr 
1               5                   10                  15      


Gly Ile His Val 
            20  


<210> 856
<211> 60
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H3"

<400> 856
actagagatg atattttgac tggtttttat gaccgctctt actattacgg tatacacgtc       60


<210> 857
<211> 324
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region"

<400> 857
gaaattgtaa tgacgcagtc tccagtcacc ctgtctgtgt ctccagggga aagagccacc       60

ctctcctgca gggccagtca gagtgttaac agcaacttag cctggtacca gaagaaacct      120

ggccaggctc ccaggctcct catctatagt gcatccacca gggccactgg tgtcccagcc      180

aggttcagtg gcagtgggtc tgggacagag ttcactctca ccgtcagcag ccttcagtct      240

gaagattttg cagtttatta ctgtcagcag tatgataact ggcctccgta cacttttggc      300

caggggacca aggtggaaat caaa                                             324


<210> 858
<211> 108
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region"

<400> 858
Glu Ile Val Met Thr Gln Ser Pro Val Thr Leu Ser Val Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Asn Ser Asn 
            20                  25                  30          


Leu Ala Trp Tyr Gln Lys Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 
        35                  40                  45              


Tyr Ser Ala Ser Thr Arg Ala Thr Gly Val Pro Ala Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Val Ser Ser Leu Gln Ser 
65                  70                  75                  80  


Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Asp Asn Trp Pro Pro 
                85                  90                  95      


Tyr Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105             


<210> 859
<211> 11
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L1"

<400> 859
Arg Ala Ser Gln Ser Val Asn Ser Asn Leu Ala 
1               5                   10      


<210> 860
<211> 33
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L1"

<400> 860
agggccagtc agagtgttaa cagcaactta gcc                                    33


<210> 861
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L2"

<400> 861
Ser Ala Ser Thr Arg Ala Thr 
1               5           


<210> 862
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L2"

<400> 862
agtgcatcca ccagggccac t                                                 21


<210> 863
<211> 10
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L3"

<400> 863
Gln Gln Tyr Asp Asn Trp Pro Pro Tyr Thr 
1               5                   10  


<210> 864
<211> 30
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L3"

<400> 864
cagcagtatg ataactggcc tccgtacact                                        30


<210> 865
<211> 381
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region"

<400> 865
caggtgcagc tgcaggagtc gggcccagga ctggtgaggc cttcacagac cctgtccctc       60

acctgctccg cctctggtgc agccatcaat agtggtgatt attactggag ttggatccgc      120

caggcccctg ggaggggcct agagtggatt gggtccattt ccaaccgtgg ggtcaccgac      180

tacaacccgt ccctcaagag tcgagttatc atatcagcgg acacgtccaa gaatcagttc      240

tccctgaggc tgacctctgt gactgccaca gacacggccg tgtattattg tgccagagat      300

ttgggtactt tggcctttga tccctactac tattacggta ttgacgtctg gggccaaggg      360

accacggtca ccgtctcctc a                                                381


<210> 866
<211> 127
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region"

<400> 866
Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Arg Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Ser Ala Ser Gly Ala Ala Ile Asn Ser Gly 
            20                  25                  30          


Asp Tyr Tyr Trp Ser Trp Ile Arg Gln Ala Pro Gly Arg Gly Leu Glu 
        35                  40                  45              


Trp Ile Gly Ser Ile Ser Asn Arg Gly Val Thr Asp Tyr Asn Pro Ser 
    50                  55                  60                  


Leu Lys Ser Arg Val Ile Ile Ser Ala Asp Thr Ser Lys Asn Gln Phe 
65                  70                  75                  80  


Ser Leu Arg Leu Thr Ser Val Thr Ala Thr Asp Thr Ala Val Tyr Tyr 
                85                  90                  95      


Cys Ala Arg Asp Leu Gly Thr Leu Ala Phe Asp Pro Tyr Tyr Tyr Tyr 
            100                 105                 110         


Gly Ile Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120                 125         


<210> 867
<211> 11
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H1"

<400> 867
Ala Ala Ile Asn Ser Gly Asp Tyr Tyr Trp Ser 
1               5                   10      


<210> 868
<211> 33
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H1"

<400> 868
gcagccatca atagtggtga ttattactgg agt                                    33


<210> 869
<211> 16
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H2"

<400> 869
Ser Ile Ser Asn Arg Gly Val Thr Asp Tyr Asn Pro Ser Leu Lys Ser 
1               5                   10                  15      


<210> 870
<211> 48
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H2"

<400> 870
tccatttcca accgtggggt caccgactac aacccgtccc tcaagagt                    48


<210> 871
<211> 19
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H3"

<400> 871
Ala Arg Asp Leu Gly Thr Leu Ala Phe Asp Pro Tyr Tyr Tyr Tyr Gly 
1               5                   10                  15      


Ile Asp Val 
            


<210> 872
<211> 57
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H3"

<400> 872
gccagagatt tgggtacttt ggcctttgat ccctactact attacggtat tgacgtc          57


<210> 873
<211> 318
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region"

<400> 873
gacatccgga tgacccagtc tccagccacc ctgtctttgt ctccagggga aagagccacc       60

ctctcctgca gggccagtca gagtgttagc aggcatttag cctggtacca acaaaaacct      120

ggccaggctc cccggctcct catctatgat gcatcataca gggtcactgg cgtcccagac      180

aggttcagtg gcagtgggtc tgggacagac ttcactctca ccatcagcag cctggagtct      240

gaagattttg caatttattt ctgtcagcag cgtagcacct ggccgacgtt cggccaaggg      300

accaaggtgg aaatcaaa                                                    318


<210> 874
<211> 106
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region"

<400> 874
Asp Ile Arg Met Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Arg His 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 
        35                  40                  45              


Tyr Asp Ala Ser Tyr Arg Val Thr Gly Val Pro Asp Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu Ser 
65                  70                  75                  80  


Glu Asp Phe Ala Ile Tyr Phe Cys Gln Gln Arg Ser Thr Trp Pro Thr 
                85                  90                  95      


Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105     


<210> 875
<211> 11
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L1"

<400> 875
Arg Ala Ser Gln Ser Val Ser Arg His Leu Ala 
1               5                   10      


<210> 876
<211> 33
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L1"

<400> 876
agggccagtc agagtgttag caggcattta gcc                                    33


<210> 877
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L2"

<400> 877
Asp Ala Ser Tyr Arg Val Thr 
1               5           


<210> 878
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L2"

<400> 878
gatgcatcat acagggtcac t                                                 21


<210> 879
<211> 8
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L3"

<400> 879
Gln Gln Arg Ser Thr Trp Pro Thr 
1               5               


<210> 880
<211> 24
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L3"

<400> 880
cagcagcgta gcacctggcc gacg                                              24


<210> 881
<211> 366
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region"

<400> 881
caggtgcagc tggtggaatc tggggctgag gtgaagaagc ctggggcctc agtgaaggtt       60

gcctgcacgg cgtctggata cgccttcacc aattacaaca tccactgggt gcgactggcc      120

cctggacagg gacttgagtg gatggcaatt atcaaccccg gtagtggtgg cacagactac      180

tcagagaagt tccagggcag gctcaccttg accagtgaca cgtccacgag cacggtgtac      240

atgacgctgg gcagcctgag atatgaagac acggcctttt attactgtgc gagaaggggt      300

taccctgatt cggggagtta cccccttgac tactggggcc agggaaccct ggtcaccgtc      360

tcctca                                                                 366


<210> 882
<211> 122
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region"

<400> 882
Gln Val Gln Leu Val Glu Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ala Cys Thr Ala Ser Gly Tyr Ala Phe Thr Asn Tyr 
            20                  25                  30          


Asn Ile His Trp Val Arg Leu Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Ala Ile Ile Asn Pro Gly Ser Gly Gly Thr Asp Tyr Ser Glu Lys Phe 
    50                  55                  60                  


Gln Gly Arg Leu Thr Leu Thr Ser Asp Thr Ser Thr Ser Thr Val Tyr 
65                  70                  75                  80  


Met Thr Leu Gly Ser Leu Arg Tyr Glu Asp Thr Ala Phe Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Arg Gly Tyr Pro Asp Ser Gly Ser Tyr Pro Leu Asp Tyr Trp 
            100                 105                 110         


Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120         


<210> 883
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H1"

<400> 883
Tyr Ala Phe Thr Asn Tyr Asn Ile His 
1               5                   


<210> 884
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H1"

<400> 884
tacgccttca ccaattacaa catccac                                           27


<210> 885
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H2"

<400> 885
Ile Ile Asn Pro Gly Ser Gly Gly Thr Asp Tyr Ser Glu Lys Phe Gln 
1               5                   10                  15      


Gly 
    


<210> 886
<211> 51
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H2"

<400> 886
attatcaacc ccggtagtgg tggcacagac tactcagaga agttccaggg c                51


<210> 887
<211> 15
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H3"

<400> 887
Ala Arg Arg Gly Tyr Pro Asp Ser Gly Ser Tyr Pro Leu Asp Tyr 
1               5                   10                  15  


<210> 888
<211> 45
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H3"

<400> 888
gcgagaaggg gttaccctga ttcggggagt tacccccttg actac                       45


<210> 889
<211> 321
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region"

<400> 889
gatattgtga tgacgcagtc tccatcctcc ctgtctgcat ctctgggaga cagagtcacc       60

atcacttgcc gggcaggtcg gagcattgcc acttacttaa attggtatca gcagaaacca      120

gggaaagccc ctaagctcct gatctatggt gcatccagtt tgcaaagtgg cgtcccatca      180

aggttcagtg gcagtggctc tgggacacat ttcactctca ccatcagcag tctgcaacct      240

gaggattttg caacttacta ctgtcaacag agttacatcc gccctatcac tttcggcgga      300

gggaccaagg tggagatcaa a                                                321


<210> 890
<211> 107
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region"

<400> 890
Asp Ile Val Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Leu Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Gly Arg Ser Ile Ala Thr Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Gly Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr His Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Tyr Ile Arg Pro Ile 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210> 891
<211> 11
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L1"

<400> 891
Arg Ala Gly Arg Ser Ile Ala Thr Tyr Leu Asn 
1               5                   10      


<210> 892
<211> 33
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L1"

<400> 892
cgggcaggtc ggagcattgc cacttactta aat                                    33


<210> 893
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L2"

<400> 893
Gly Ala Ser Ser Leu Gln Ser 
1               5           


<210> 894
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L2"

<400> 894
ggtgcatcca gtttgcaaag t                                                 21


<210> 895
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L3"

<400> 895
Gln Gln Ser Tyr Ile Arg Pro Ile Thr 
1               5                   


<210> 896
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L3"

<400> 896
caacagagtt acatccgccc tatcact                                           27


<210> 897
<211> 381
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region"

<400> 897
caggtgcagc tgcaggagtc cggcccagga ctggtgaagc cttcacagac cctgtccctc       60

acctgcactg tctctggtcg tctcctcagc agtggtgatt actactggag ttggatccgc      120

cagtccccag ggaggggcct ggagtggatt ggctacgtct atcacagtgg gaccacctcg      180

tacaacccgt ccctcaagag tcgaattacc atgacagtgg acacgtccaa gaaccagttc      240

aacctgaggt tgacctctgt aacggccgca gacacggccg tgtattactg tgccagagat      300

ctcggatata gcagttcctc tcccgccttt tattacggta tagacttctg gggcccaggg      360

accatggtca ccgtctcttc a                                                381


<210> 898
<211> 127
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region"

<400> 898
Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Arg Leu Leu Ser Ser Gly 
            20                  25                  30          


Asp Tyr Tyr Trp Ser Trp Ile Arg Gln Ser Pro Gly Arg Gly Leu Glu 
        35                  40                  45              


Trp Ile Gly Tyr Val Tyr His Ser Gly Thr Thr Ser Tyr Asn Pro Ser 
    50                  55                  60                  


Leu Lys Ser Arg Ile Thr Met Thr Val Asp Thr Ser Lys Asn Gln Phe 
65                  70                  75                  80  


Asn Leu Arg Leu Thr Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr 
                85                  90                  95      


Cys Ala Arg Asp Leu Gly Tyr Ser Ser Ser Ser Pro Ala Phe Tyr Tyr 
            100                 105                 110         


Gly Ile Asp Phe Trp Gly Pro Gly Thr Met Val Thr Val Ser Ser 
        115                 120                 125         


<210> 899
<211> 11
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H1"

<400> 899
Arg Leu Leu Ser Ser Gly Asp Tyr Tyr Trp Ser 
1               5                   10      


<210> 900
<211> 33
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H1"

<400> 900
cgtctcctca gcagtggtga ttactactgg agt                                    33


<210> 901
<211> 16
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H2"

<400> 901
Tyr Val Tyr His Ser Gly Thr Thr Ser Tyr Asn Pro Ser Leu Lys Ser 
1               5                   10                  15      


<210> 902
<211> 48
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H2"

<400> 902
tacgtctatc acagtgggac cacctcgtac aacccgtccc tcaagagt                    48


<210> 903
<211> 19
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H3"

<400> 903
Ala Arg Asp Leu Gly Tyr Ser Ser Ser Ser Pro Ala Phe Tyr Tyr Gly 
1               5                   10                  15      


Ile Asp Phe 
            


<210> 904
<211> 57
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H3"

<400> 904
gccagagatc tcggatatag cagttcctct cccgcctttt attacggtat agacttc          57


<210> 905
<211> 321
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region"

<400> 905
gaaattgtat tgacacagtc tccagccacc ctgtctttgt ctccagggca aagagcgacc       60

ctctcctgca gggccagtca gagtgttggc aactacttag cctggtacca acaaaaacct      120

ggccaggctc ccaggctcct catctatgat gcatccaaca gggtcactgg catcccagcc      180

aggttcagtg gcagtgggtc tgggacagac ttcactctca ccatcagcag gctagagtct      240

gaagattttg cagtttatta ctgtcagcag cgtagcaacg gggtcctcac tttcggcgga      300

gggaccaaag tggatatcaa a                                                321


<210> 906
<211> 107
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region"

<400> 906
Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Gln Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Gly Asn Tyr 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 
        35                  40                  45              


Tyr Asp Ala Ser Asn Arg Val Thr Gly Ile Pro Ala Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu Ser 
65                  70                  75                  80  


Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Arg Ser Asn Gly Val Leu 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Val Asp Ile Lys 
            100                 105         


<210> 907
<211> 11
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L1"

<400> 907
Arg Ala Ser Gln Ser Val Gly Asn Tyr Leu Ala 
1               5                   10      


<210> 908
<211> 33
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L1"

<400> 908
agggccagtc agagtgttgg caactactta gcc                                    33


<210> 909
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L2"

<400> 909
Asp Ala Ser Asn Arg Val Thr 
1               5           


<210> 910
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L2"

<400> 910
gatgcatcca acagggtcac t                                                 21


<210> 911
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L3"

<400> 911
Gln Gln Arg Ser Asn Gly Val Leu Thr 
1               5                   


<210> 912
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L3"

<400> 912
cagcagcgta gcaacggggt cctcact                                           27


<210> 913
<211> 363
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region"

<400> 913
gaggtgcagc tgttggagtc tggggctgag gtgaagaagc ctggggcctc agtgagggtc       60

tcctgcaagg cttctggata caccttcacc gactacttta tgaactgggt gcgacaggcc      120

cctggagggg gccttgagtg gatggggtgg gtcaatcctc tcagtggagc cacaaaatat      180

gcacagaagt ttcagggcag ggtcaccatg accacggaca cgtccatcac cacagggtac      240

ctggacttga ggagcctgag agttgacgac acggccatct atttttgtgc gagccagtct      300

tccccttaca ccccgggcgc tatgggcgtc tggggccaag ggaccacggt caccgtctct      360

tca                                                                    363


<210> 914
<211> 121
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region"

<400> 914
Glu Val Gln Leu Leu Glu Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Arg Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Tyr 
            20                  25                  30          


Phe Met Asn Trp Val Arg Gln Ala Pro Gly Gly Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Val Asn Pro Leu Ser Gly Ala Thr Lys Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Met Thr Thr Asp Thr Ser Ile Thr Thr Gly Tyr 
65                  70                  75                  80  


Leu Asp Leu Arg Ser Leu Arg Val Asp Asp Thr Ala Ile Tyr Phe Cys 
                85                  90                  95      


Ala Ser Gln Ser Ser Pro Tyr Thr Pro Gly Ala Met Gly Val Trp Gly 
            100                 105                 110         


Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120     


<210> 915
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H1"

<400> 915
Tyr Thr Phe Thr Asp Tyr Phe Met Asn 
1               5                   


<210> 916
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H1"

<400> 916
tacaccttca ccgactactt tatgaac                                           27


<210> 917
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H2"

<400> 917
Trp Val Asn Pro Leu Ser Gly Ala Thr Lys Tyr Ala Gln Lys Phe Gln 
1               5                   10                  15      


Gly 
    


<210> 918
<211> 51
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H2"

<400> 918
tgggtcaatc ctctcagtgg agccacaaaa tatgcacaga agtttcaggg c                51


<210> 919
<211> 14
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H3"

<400> 919
Ala Ser Gln Ser Ser Pro Tyr Thr Pro Gly Ala Met Gly Val 
1               5                   10                  


<210> 920
<211> 42
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H3"

<400> 920
gcgagccagt cttcccctta caccccgggc gctatgggcg tc                          42


<210> 921
<211> 321
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region"

<400> 921
gacatccagg tgacccagtc tccatcctcc ctgtctgcct ctgtaggaga cagagtcacc       60

atcacttgcc gggcaagtca gagcattagc ggctatttaa gttggtatca gcagaaacca      120

gggaaagccc ctaacctcct gatctatgct acatccaatt tatacagtgg ggtcccatca      180

aggttcagtg gccgtgattc tgggacagat ttcactctca ccatcaccag tctgcaacct      240

gaagattttg caacttactt ctgtcaactg aattccggtg ccctattcac tttcggccct      300

gggaccaagg tggagatcaa a                                                321


<210> 922
<211> 107
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region"

<400> 922
Asp Ile Gln Val Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Gly Tyr 
            20                  25                  30          


Leu Ser Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Asn Leu Leu Ile 
        35                  40                  45              


Tyr Ala Thr Ser Asn Leu Tyr Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Arg Asp Ser Gly Thr Asp Phe Thr Leu Thr Ile Thr Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Phe Cys Gln Leu Asn Ser Gly Ala Leu Phe 
                85                  90                  95      


Thr Phe Gly Pro Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210> 923
<211> 11
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L1"

<400> 923
Arg Ala Ser Gln Ser Ile Ser Gly Tyr Leu Ser 
1               5                   10      


<210> 924
<211> 33
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L1"

<400> 924
cgggcaagtc agagcattag cggctattta agt                                    33


<210> 925
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L2"

<400> 925
Ala Thr Ser Asn Leu Tyr Ser 
1               5           


<210> 926
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L2"

<400> 926
gctacatcca atttatacag t                                                 21


<210> 927
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L3"

<400> 927
Gln Leu Asn Ser Gly Ala Leu Phe Thr 
1               5                   


<210> 928
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L3"

<400> 928
caactgaatt ccggtgccct attcact                                           27


<210> 929
<211> 384
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region"

<400> 929
caggtgcagc tgcaggagtc gggcccagga ctggtgaagc cttcacagac cctgtccctc       60

acctgcactg tctctggtcc ctccatcagc gctggagatt acaactggaa ttggatccgc      120

caggccccag ggaagggcct ggagtgggtt ggatacatcg attacagggg cctcacccac      180

tacaacccgt ccctcaaggg tcgactttcc atattaatgg acaggtcggc gaaccagttc      240

tccctggagc tgaattctgt gactgccgca gacacggccg tctactactg tgccagggac      300

gtgggggtct atagtggcta cgatgtcttt cactactacg gcatggacgt ctggggccag      360

gggaccacgg tcaccgtctc ctca                                             384


<210> 930
<211> 128
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region"

<400> 930
Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Pro Ser Ile Ser Ala Gly 
            20                  25                  30          


Asp Tyr Asn Trp Asn Trp Ile Arg Gln Ala Pro Gly Lys Gly Leu Glu 
        35                  40                  45              


Trp Val Gly Tyr Ile Asp Tyr Arg Gly Leu Thr His Tyr Asn Pro Ser 
    50                  55                  60                  


Leu Lys Gly Arg Leu Ser Ile Leu Met Asp Arg Ser Ala Asn Gln Phe 
65                  70                  75                  80  


Ser Leu Glu Leu Asn Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr 
                85                  90                  95      


Cys Ala Arg Asp Val Gly Val Tyr Ser Gly Tyr Asp Val Phe His Tyr 
            100                 105                 110         


Tyr Gly Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120                 125             


<210> 931
<211> 11
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H1"

<400> 931
Pro Ser Ile Ser Ala Gly Asp Tyr Asn Trp Asn 
1               5                   10      


<210> 932
<211> 33
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H1"

<400> 932
ccctccatca gcgctggaga ttacaactgg aat                                    33


<210> 933
<211> 16
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H2"

<400> 933
Tyr Ile Asp Tyr Arg Gly Leu Thr His Tyr Asn Pro Ser Leu Lys Gly 
1               5                   10                  15      


<210> 934
<211> 48
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H2"

<400> 934
tacatcgatt acaggggcct cacccactac aacccgtccc tcaagggt                    48


<210> 935
<211> 20
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H3"

<400> 935
Ala Arg Asp Val Gly Val Tyr Ser Gly Tyr Asp Val Phe His Tyr Tyr 
1               5                   10                  15      


Gly Met Asp Val 
            20  


<210> 936
<211> 60
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H3"

<400> 936
gccagggacg tgggggtcta tagtggctac gatgtctttc actactacgg catggacgtc       60


<210> 937
<211> 327
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region"

<400> 937
gaaacgacac tcacgcagtc tccagtcacc ctgtctttgt ctccagggga aagagccacc       60

ctctcctgca gggccagtca gtatgttagg aacaactact tagcctggta ccaacacaaa      120

cctggccagg ctcccaggct cctcatctat agtgcttcca gcagggtcac tggcacccca      180

gacaggttca gtggcagtgg gtctgggaca gacttcactc tcaccatcag cagactggag      240

cctgaagact ttgcagtgta ttactgtcag cagtatggtg gctcacctcc ggtcactttc      300

ggccctggga ccaaagtgga tatcaaa                                          327


<210> 938
<211> 109
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region"

<400> 938
Glu Thr Thr Leu Thr Gln Ser Pro Val Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Tyr Val Arg Asn Asn 
            20                  25                  30          


Tyr Leu Ala Trp Tyr Gln His Lys Pro Gly Gln Ala Pro Arg Leu Leu 
        35                  40                  45              


Ile Tyr Ser Ala Ser Ser Arg Val Thr Gly Thr Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu 
65                  70                  75                  80  


Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Gly Gly Ser Pro 
                85                  90                  95      


Pro Val Thr Phe Gly Pro Gly Thr Lys Val Asp Ile Lys 
            100                 105                 


<210> 939
<211> 12
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L1"

<400> 939
Arg Ala Ser Gln Tyr Val Arg Asn Asn Tyr Leu Ala 
1               5                   10          


<210> 940
<211> 36
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L1"

<400> 940
agggccagtc agtatgttag gaacaactac ttagcc                                 36


<210> 941
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L2"

<400> 941
Ser Ala Ser Ser Arg Val Thr 
1               5           


<210> 942
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L2"

<400> 942
agtgcttcca gcagggtcac t                                                 21


<210> 943
<211> 10
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L3"

<400> 943
Gln Gln Tyr Gly Gly Ser Pro Pro Val Thr 
1               5                   10  


<210> 944
<211> 30
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L3"

<400> 944
cagcagtatg gtggctcacc tccggtcact                                        30


<210> 945
<211> 360
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region"

<400> 945
gaggtgcagc tgttggagtc cgggggaggc ttagttcagc ctggggggtc cctgagacta       60

tcctgtgcag cctctggatt caccttcagt aattactgga tgcactgggt ccgccaagct      120

ccagggaagg ggctggtgtg ggtctcacgt attagcggtg atggaagtga cacaacctac      180

gcggactccg tggagggccg attcaccatc tccagagaca acgccaggag tacactgtat      240

cttcaactga atagtctcac aggcgacgac acggctgtgt attattgtgc aagagatttg      300

tggaccacct cgccctactt tgacctctgg ggccagggaa ccctggtcac cgtctcctca      360


<210> 946
<211> 120
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region"

<400> 946
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Tyr 
            20                  25                  30          


Trp Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Val Trp Val 
        35                  40                  45              


Ser Arg Ile Ser Gly Asp Gly Ser Asp Thr Thr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Glu Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Arg Ser Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Leu Asn Ser Leu Thr Gly Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Leu Trp Thr Thr Ser Pro Tyr Phe Asp Leu Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser 
        115                 120 


<210> 947
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H1"

<400> 947
Phe Thr Phe Ser Asn Tyr Trp Met His 
1               5                   


<210> 948
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H1"

<400> 948
ttcaccttca gtaattactg gatgcac                                           27


<210> 949
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H2"

<400> 949
Arg Ile Ser Gly Asp Gly Ser Asp Thr Thr Tyr Ala Asp Ser Val Glu 
1               5                   10                  15      


Gly 
    


<210> 950
<211> 51
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H2"

<400> 950
cgtattagcg gtgatggaag tgacacaacc tacgcggact ccgtggaggg c                51


<210> 951
<211> 13
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H3"

<400> 951
Ala Arg Asp Leu Trp Thr Thr Ser Pro Tyr Phe Asp Leu 
1               5                   10              


<210> 952
<211> 39
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H3"

<400> 952
gcaagagatt tgtggaccac ctcgccctac tttgacctc                              39


<210> 953
<211> 315
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region"

<400> 953
gaaattgtat tgacacagtc tcctggcacc ctgtctgcat ctattggaga cagagtcacc       60

atcacttgcc gggccagtca gagtcttaat ggctggttgg cctggtatca gcagaaacca      120

gggaaagccc ctaggctcct catctataag tcgtctagtt tagaaagcgg ggtcccatca      180

aggttcagcg gcagtgcatc tgggacagaa ttcactctca ccatcagcag cctgcagcct      240

gacgattttg caacttatta ctgccaacag tataatagtt gggcgttcgg ccaagggacc      300

aaggtggacg tcaaa                                                       315


<210> 954
<211> 105
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region"

<400> 954
Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Ala Ser Ile Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Leu Asn Gly Trp 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Arg Leu Leu Ile 
        35                  40                  45              


Tyr Lys Ser Ser Ser Leu Glu Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Ala Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Asp Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Asn Ser Trp Ala Phe 
                85                  90                  95      


Gly Gln Gly Thr Lys Val Asp Val Lys 
            100                 105 


<210> 955
<211> 11
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L1"

<400> 955
Arg Ala Ser Gln Ser Leu Asn Gly Trp Leu Ala 
1               5                   10      


<210> 956
<211> 33
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L1"

<400> 956
cgggccagtc agagtcttaa tggctggttg gcc                                    33


<210> 957
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L2"

<400> 957
Lys Ser Ser Ser Leu Glu Ser 
1               5           


<210> 958
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L2"

<400> 958
aagtcgtcta gtttagaaag c                                                 21


<210> 959
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L3"

<400> 959
Gln Gln Tyr Asn Ser Trp Ala 
1               5           


<210> 960
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L3"

<400> 960
caacagtata atagttgggc g                                                 21


<210> 961
<211> 378
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region"

<400> 961
caggtgcagc tacagcagtg gggcgcagga ctgttgaagc cttcggagac cctgtccctc       60

acctgcgctg tctatggtgg gtccttcagt ggttactcct ggagctggat ccgccagtcc      120

ccagggaagg ggctggagtg gattggagaa atcaatcata gaggaagcac caactacaac      180

ccgtccctca agagtcgagt caccatatca gtagacacgt cgaagaacca gttctccctg      240

aagctgagct ctgtgaccgc cgcggacacg gctgtgtact actgtgcggg gaccaattat      300

ggagaggtta atacgagtaa ccaatacttc ttcggtatgg acgtctgggg ccaagggacc      360

acggtcaccg tctcctca                                                    378


<210> 962
<211> 126
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region"

<400> 962
Gln Val Gln Leu Gln Gln Trp Gly Ala Gly Leu Leu Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Ala Val Tyr Gly Gly Ser Phe Ser Gly Tyr 
            20                  25                  30          


Ser Trp Ser Trp Ile Arg Gln Ser Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Glu Ile Asn His Arg Gly Ser Thr Asn Tyr Asn Pro Ser Leu Lys 
    50                  55                  60                  


Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe Ser Leu 
65                  70                  75                  80  


Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Gly Thr Asn Tyr Gly Glu Val Asn Thr Ser Asn Gln Tyr Phe Phe Gly 
            100                 105                 110         


Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120                 125     


<210> 963
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H1"

<400> 963
Gly Ser Phe Ser Gly Tyr Ser Trp Ser 
1               5                   


<210> 964
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H1"

<400> 964
gggtccttca gtggttactc ctggagc                                           27


<210> 965
<211> 16
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H2"

<400> 965
Glu Ile Asn His Arg Gly Ser Thr Asn Tyr Asn Pro Ser Leu Lys Ser 
1               5                   10                  15      


<210> 966
<211> 48
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H2"

<400> 966
gaaatcaatc atagaggaag caccaactac aacccgtccc tcaagagt                    48


<210> 967
<211> 20
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H3"

<400> 967
Ala Gly Thr Asn Tyr Gly Glu Val Asn Thr Ser Asn Gln Tyr Phe Phe 
1               5                   10                  15      


Gly Met Asp Val 
            20  


<210> 968
<211> 60
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H3"

<400> 968
gcggggacca attatggaga ggttaatacg agtaaccaat acttcttcgg tatggacgtc       60


<210> 969
<211> 321
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region"

<400> 969
gacatccggt tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga cagagtcacc       60

atcacttgcc gggcaagtca gagcattacc acctatttaa attggtatca gcagaaacca      120

gggaaagccc ctaaactcct gatctatgct gcatccaatt tggaaagtgg ggtcccatca      180

agtttcagtg gcagtggatt tgggacagac ttcactctca ccatcagcag tctgcaacct      240

gacgattttg caacttacta ctgtcaacag agttacagtg ccccgctcac cttcggcgga      300

gggaccaaag tggatatcaa a                                                321


<210> 970
<211> 107
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region"

<400> 970
Asp Ile Arg Leu Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Thr Thr Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Asn Leu Glu Ser Gly Val Pro Ser Ser Phe Ser Gly 
    50                  55                  60                  


Ser Gly Phe Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Asp Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Tyr Ser Ala Pro Leu 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Val Asp Ile Lys 
            100                 105         


<210> 971
<211> 11
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L1"

<400> 971
Arg Ala Ser Gln Ser Ile Thr Thr Tyr Leu Asn 
1               5                   10      


<210> 972
<211> 33
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L1"

<400> 972
cgggcaagtc agagcattac cacctattta aat                                    33


<210> 973
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L2"

<400> 973
Ala Ala Ser Asn Leu Glu Ser 
1               5           


<210> 974
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L2"

<400> 974
gctgcatcca atttggaaag t                                                 21


<210> 975
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L3"

<400> 975
Gln Gln Ser Tyr Ser Ala Pro Leu Thr 
1               5                   


<210> 976
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L3"

<400> 976
caacagagtt acagtgcccc gctcacc                                           27


<210> 977
<211> 363
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region"

<400> 977
caggtccagc tggtacagtc tggggctggg gtgaagaagc ctggggcctc agtgagggtc       60

tcatgcacgg cctctggata caccttcacc gactacttta taaactgggt gcgacaggcc      120

cctggagggg gccttgagtg gatggggtgg gtcaatcctc tcagtggagc cacaagatac      180

gcccagaact ttgcgggcag ggtcaccatg accacggaca cgtccatcac cacaggatat      240

ctggacttac ggaacctgcg acttgacgac acggccgtct atttttgtgc gagccagtct      300

tcaccttaca cgccgggcgc tatggacgtc tggggccaag ggaccacggt caccgtctcc      360

tca                                                                    363


<210> 978
<211> 121
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region"

<400> 978
Gln Val Gln Leu Val Gln Ser Gly Ala Gly Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Arg Val Ser Cys Thr Ala Ser Gly Tyr Thr Phe Thr Asp Tyr 
            20                  25                  30          


Phe Ile Asn Trp Val Arg Gln Ala Pro Gly Gly Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Val Asn Pro Leu Ser Gly Ala Thr Arg Tyr Ala Gln Asn Phe 
    50                  55                  60                  


Ala Gly Arg Val Thr Met Thr Thr Asp Thr Ser Ile Thr Thr Gly Tyr 
65                  70                  75                  80  


Leu Asp Leu Arg Asn Leu Arg Leu Asp Asp Thr Ala Val Tyr Phe Cys 
                85                  90                  95      


Ala Ser Gln Ser Ser Pro Tyr Thr Pro Gly Ala Met Asp Val Trp Gly 
            100                 105                 110         


Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120     


<210> 979
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H1"

<400> 979
Tyr Thr Phe Thr Asp Tyr Phe Ile Asn 
1               5                   


<210> 980
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H1"

<400> 980
tacaccttca ccgactactt tataaac                                           27


<210> 981
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H2"

<400> 981
Trp Val Asn Pro Leu Ser Gly Ala Thr Arg Tyr Ala Gln Asn Phe Ala 
1               5                   10                  15      


Gly 
    


<210> 982
<211> 51
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H2"

<400> 982
tgggtcaatc ctctcagtgg agccacaaga tacgcccaga actttgcggg c                51


<210> 983
<211> 14
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H3"

<400> 983
Ala Ser Gln Ser Ser Pro Tyr Thr Pro Gly Ala Met Asp Val 
1               5                   10                  


<210> 984
<211> 42
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H3"

<400> 984
gcgagccagt cttcacctta cacgccgggc gctatggacg tc                          42


<210> 985
<211> 321
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region"

<400> 985
gatattgtga tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga cagagtctcc       60

atcacttgcc ggacaagtca gaccattagt ggctatataa gttggtatca gaagaaacca      120

ggaaaagccc ctaaactcct gatctatgct gcatcaaata tgtacagtgg ggtcccatca      180

aggttcagtg gcagtgaatc tgggacagat ttcactctca ccatcaccag tctgcaacct      240

gaagattttg caacttactt ctgtcaactg aattccggtg ccctattcac tttcggccct      300

gggaccaaag tggatatcaa a                                                321


<210> 986
<211> 107
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region"

<400> 986
Asp Ile Val Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Ser Ile Thr Cys Arg Thr Ser Gln Thr Ile Ser Gly Tyr 
            20                  25                  30          


Ile Ser Trp Tyr Gln Lys Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Asn Met Tyr Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Glu Ser Gly Thr Asp Phe Thr Leu Thr Ile Thr Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Phe Cys Gln Leu Asn Ser Gly Ala Leu Phe 
                85                  90                  95      


Thr Phe Gly Pro Gly Thr Lys Val Asp Ile Lys 
            100                 105         


<210> 987
<211> 11
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L1"

<400> 987
Arg Thr Ser Gln Thr Ile Ser Gly Tyr Ile Ser 
1               5                   10      


<210> 988
<211> 33
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L1"

<400> 988
cggacaagtc agaccattag tggctatata agt                                    33


<210> 989
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L2"

<400> 989
Ala Ala Ser Asn Met Tyr Ser 
1               5           


<210> 990
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L2"

<400> 990
gctgcatcaa atatgtacag t                                                 21


<210> 991
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L3"

<400> 991
Gln Leu Asn Ser Gly Ala Leu Phe Thr 
1               5                   


<210> 992
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L3"

<400> 992
caactgaatt ccggtgccct attcact                                           27


<210> 993
<211> 357
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region"

<400> 993
gaggtgcagc tggtggagtc tgcagcagag gtgaaaaagc ccggggagtc tctgaagatc       60

tcctgtaagg gttctggata cagttttgcc agccactgga tcggttgggt ccgccaaatg      120

cccgggaaag gcctggagtt gatgggattc atctatcctg gtgactctga taccagatac      180

aacccgtcct tccaaggcca ggtcaccatc tcagccgaca agtccatcag caccgcctac      240

ctgcagtgga ccaggctgaa ggcctcggac accgccatgt actactgtgg ccaggcagtg      300

gcggggggtg aatatttcca ccactggggc cagggcaccc tggtcaccgt ctcctca         357


<210> 994
<211> 119
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region"

<400> 994
Glu Val Gln Leu Val Glu Ser Ala Ala Glu Val Lys Lys Pro Gly Glu 
1               5                   10                  15      


Ser Leu Lys Ile Ser Cys Lys Gly Ser Gly Tyr Ser Phe Ala Ser His 
            20                  25                  30          


Trp Ile Gly Trp Val Arg Gln Met Pro Gly Lys Gly Leu Glu Leu Met 
        35                  40                  45              


Gly Phe Ile Tyr Pro Gly Asp Ser Asp Thr Arg Tyr Asn Pro Ser Phe 
    50                  55                  60                  


Gln Gly Gln Val Thr Ile Ser Ala Asp Lys Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Trp Thr Arg Leu Lys Ala Ser Asp Thr Ala Met Tyr Tyr Cys 
                85                  90                  95      


Gly Gln Ala Val Ala Gly Gly Glu Tyr Phe His His Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210> 995
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H1"

<400> 995
Tyr Ser Phe Ala Ser His Trp Ile Gly 
1               5                   


<210> 996
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H1"

<400> 996
tacagttttg ccagccactg gatcggt                                           27


<210> 997
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H2"

<400> 997
Phe Ile Tyr Pro Gly Asp Ser Asp Thr Arg Tyr Asn Pro Ser Phe Gln 
1               5                   10                  15      


Gly 
    


<210> 998
<211> 51
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H2"

<400> 998
ttcatctatc ctggtgactc tgataccaga tacaacccgt ccttccaagg c                51


<210> 999
<211> 12
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H3"

<400> 999
Gly Gln Ala Val Ala Gly Gly Glu Tyr Phe His His 
1               5                   10          


<210> 1000
<211> 36
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H3"

<400> 1000
ggccaggcag tggcgggggg tgaatatttc caccac                                 36


<210> 1001
<211> 321
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region"

<400> 1001
gatattgtga tgacgcagtc tccagccacc ctgtctgtgt ctccagggga aagagccacc       60

ctctcctgca gggccagtca gagtcttggc agcgacttag cctggtacca gcagaaacct      120

ggccagactc ccaggctcct catctatgat gcatccacca gggccactgg tatcccagcc      180

aggttcagtg gcagtgggtc tgggacagag ttcactctca ccatcagcag cctgcagtct      240

gaagattttg cagtttatta ctgtcagcac tataataatt ggccccgggg gttcggccaa      300

gggaccaagg tggaaatcaa a                                                321


<210> 1002
<211> 107
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region"

<400> 1002
Asp Ile Val Met Thr Gln Ser Pro Ala Thr Leu Ser Val Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Leu Gly Ser Asp 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Thr Pro Arg Leu Leu Ile 
        35                  40                  45              


Tyr Asp Ala Ser Thr Arg Ala Thr Gly Ile Pro Ala Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Ser 
65                  70                  75                  80  


Glu Asp Phe Ala Val Tyr Tyr Cys Gln His Tyr Asn Asn Trp Pro Arg 
                85                  90                  95      


Gly Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210> 1003
<211> 11
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L1"

<400> 1003
Arg Ala Ser Gln Ser Leu Gly Ser Asp Leu Ala 
1               5                   10      


<210> 1004
<211> 33
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L1"

<400> 1004
agggccagtc agagtcttgg cagcgactta gcc                                    33


<210> 1005
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L2"

<400> 1005
Asp Ala Ser Thr Arg Ala Thr 
1               5           


<210> 1006
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L2"

<400> 1006
gatgcatcca ccagggccac t                                                 21


<210> 1007
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L3"

<400> 1007
Gln His Tyr Asn Asn Trp Pro Arg Gly 
1               5                   


<210> 1008
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L3"

<400> 1008
cagcactata ataattggcc ccggggg                                           27


<210> 1009
<211> 372
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region"

<400> 1009
caggtgcagc tgcaggagtc gggcccagga cgggtgaagc cttcacagac cctgtccctc       60

acctgcactg tctctggtgt ctccgtcacc attaatgatt actactggac ttggctccgc      120

cagtccccag ggaaaggcct ggagtggatt ggaaacatct ataacagtgg gagcacctac      180

cagaacccgt ccctccagag tcgagttacc atgtcagtgg acacggccaa gaaccacttc      240

tccctgaagc tgacctctgt cactgccgca gatacggccg tctattactg tgccagagat      300

ttaggcactg ccaacaacta ctacttcggt atggacgtct ggggcctagg gaccacggtc      360

accgtctcct ca                                                          372


<210> 1010
<211> 124
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region"

<400> 1010
Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Arg Val Lys Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Val Ser Val Thr Ile Asn 
            20                  25                  30          


Asp Tyr Tyr Trp Thr Trp Leu Arg Gln Ser Pro Gly Lys Gly Leu Glu 
        35                  40                  45              


Trp Ile Gly Asn Ile Tyr Asn Ser Gly Ser Thr Tyr Gln Asn Pro Ser 
    50                  55                  60                  


Leu Gln Ser Arg Val Thr Met Ser Val Asp Thr Ala Lys Asn His Phe 
65                  70                  75                  80  


Ser Leu Lys Leu Thr Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr 
                85                  90                  95      


Cys Ala Arg Asp Leu Gly Thr Ala Asn Asn Tyr Tyr Phe Gly Met Asp 
            100                 105                 110         


Val Trp Gly Leu Gly Thr Thr Val Thr Val Ser Ser 
        115                 120                 


<210> 1011
<211> 11
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H1"

<400> 1011
Val Ser Val Thr Ile Asn Asp Tyr Tyr Trp Thr 
1               5                   10      


<210> 1012
<211> 33
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H1"

<400> 1012
gtctccgtca ccattaatga ttactactgg act                                    33


<210> 1013
<211> 16
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H2"

<400> 1013
Asn Ile Tyr Asn Ser Gly Ser Thr Tyr Gln Asn Pro Ser Leu Gln Ser 
1               5                   10                  15      


<210> 1014
<211> 48
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H2"

<400> 1014
aacatctata acagtgggag cacctaccag aacccgtccc tccagagt                    48


<210> 1015
<211> 16
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H3"

<400> 1015
Ala Arg Asp Leu Gly Thr Ala Asn Asn Tyr Tyr Phe Gly Met Asp Val 
1               5                   10                  15      


<210> 1016
<211> 48
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H3"

<400> 1016
gccagagatt taggcactgc caacaactac tacttcggta tggacgtc                    48


<210> 1017
<211> 324
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region"

<400> 1017
gaaattgtga tgacgcagtc tccagccacc ctgtctttgt ctccagggga aagagccact       60

ctctcctgca gggccagtca gagtgttagc acctacttag cctggtacca acagaaacct      120

ggccaggctc ccaggctcct catctataat ggatccaaca gggtcactgg caccccagcc      180

aggttcagtg gcagtgggtc tgggacagac ttcactctca ccatcagcag cgtagagcct      240

gaagattttg cagtttatta ctgtcagcag cgtagcaact ggcctccgta cacttttggc      300

caggggacca aggtggagat caaa                                             324


<210> 1018
<211> 108
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region"

<400> 1018
Glu Ile Val Met Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Thr Tyr 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 
        35                  40                  45              


Tyr Asn Gly Ser Asn Arg Val Thr Gly Thr Pro Ala Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Val Glu Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Arg Ser Asn Trp Pro Pro 
                85                  90                  95      


Tyr Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105             


<210> 1019
<211> 11
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L1"

<400> 1019
Arg Ala Ser Gln Ser Val Ser Thr Tyr Leu Ala 
1               5                   10      


<210> 1020
<211> 33
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L1"

<400> 1020
agggccagtc agagtgttag cacctactta gcc                                    33


<210> 1021
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L2"

<400> 1021
Asn Gly Ser Asn Arg Val Thr 
1               5           


<210> 1022
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L2"

<400> 1022
aatggatcca acagggtcac t                                                 21


<210> 1023
<211> 10
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L3"

<400> 1023
Gln Gln Arg Ser Asn Trp Pro Pro Tyr Thr 
1               5                   10  


<210> 1024
<211> 30
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L3"

<400> 1024
cagcagcgta gcaactggcc tccgtacact                                        30


<210> 1025
<211> 381
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region"

<400> 1025
caggtgcagc tgcaggagtc gggcccagga ctggtgaagc cttcggagac cctgtccctc       60

acctgctcgg tctctggtgc ctccgtcacc agtagggaat actactgggg ctggatccgc      120

caggcccccg ggaagggtct gcagtggatt gccagcattc atcacagtcc ttttcaaagt      180

gacggcaacc cgtccctgac gagtcgcgtc tccagttccg tagtcacgtc caagaaccag      240

ttggccctga ggctgagctc tgtgaccgcc gcagacacgg ctgtatatta ctgtgcgggc      300

gcgttttggg aggtttggac tggcctttat tcaccgccgt ttgacttttg gggccaggga      360

atcctggtca ccgtctcctc a                                                381


<210> 1026
<211> 127
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region"

<400> 1026
Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Ser Val Ser Gly Ala Ser Val Thr Ser Arg 
            20                  25                  30          


Glu Tyr Tyr Trp Gly Trp Ile Arg Gln Ala Pro Gly Lys Gly Leu Gln 
        35                  40                  45              


Trp Ile Ala Ser Ile His His Ser Pro Phe Gln Ser Asp Gly Asn Pro 
    50                  55                  60                  


Ser Leu Thr Ser Arg Val Ser Ser Ser Val Val Thr Ser Lys Asn Gln 
65                  70                  75                  80  


Leu Ala Leu Arg Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Ala Gly Ala Phe Trp Glu Val Trp Thr Gly Leu Tyr Ser Pro 
            100                 105                 110         


Pro Phe Asp Phe Trp Gly Gln Gly Ile Leu Val Thr Val Ser Ser 
        115                 120                 125         


<210> 1027
<211> 11
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H1"

<400> 1027
Ala Ser Val Thr Ser Arg Glu Tyr Tyr Trp Gly 
1               5                   10      


<210> 1028
<211> 33
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H1"

<400> 1028
gcctccgtca ccagtaggga atactactgg ggc                                    33


<210> 1029
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H2"

<400> 1029
Ser Ile His His Ser Pro Phe Gln Ser Asp Gly Asn Pro Ser Leu Thr 
1               5                   10                  15      


Ser 
    


<210> 1030
<211> 51
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H2"

<400> 1030
agcattcatc acagtccttt tcaaagtgac ggcaacccgt ccctgacgag t                51


<210> 1031
<211> 18
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H3"

<400> 1031
Ala Gly Ala Phe Trp Glu Val Trp Thr Gly Leu Tyr Ser Pro Pro Phe 
1               5                   10                  15      


Asp Phe 
        


<210> 1032
<211> 54
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H3"

<400> 1032
gcgggcgcgt tttgggaggt ttggactggc ctttattcac cgccgtttga cttt             54


<210> 1033
<211> 324
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region"

<400> 1033
gaaattgtaa tgacacagtc tccagggacc ctgtctttgt ctccagggga aagagccacc       60

ctctcctgct gggccagtca gactgttagc agcggctact tagcctggta ccagcagaaa      120

cctggccagg ctcccaggct cctcatctat ggtgcatcta ccagggccac tgacatccca      180

gacaggttca gtggcagtgg gtctgggaca ggcttcactc tcaccatcag cagactggag      240

cctgaagatc ttgcagtcta ttactgtcag cagtatagca gttcaccact cactttcggc      300

ggcgggacca aggtggaaat caaa                                             324


<210> 1034
<211> 108
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region"

<400> 1034
Glu Ile Val Met Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Trp Ala Ser Gln Thr Val Ser Ser Gly 
            20                  25                  30          


Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu 
        35                  40                  45              


Ile Tyr Gly Ala Ser Thr Arg Ala Thr Asp Ile Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Gly Phe Thr Leu Thr Ile Ser Arg Leu Glu 
65                  70                  75                  80  


Pro Glu Asp Leu Ala Val Tyr Tyr Cys Gln Gln Tyr Ser Ser Ser Pro 
                85                  90                  95      


Leu Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105             


<210> 1035
<211> 12
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L1"

<400> 1035
Trp Ala Ser Gln Thr Val Ser Ser Gly Tyr Leu Ala 
1               5                   10          


<210> 1036
<211> 36
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L1"

<400> 1036
tgggccagtc agactgttag cagcggctac ttagcc                                 36


<210> 1037
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L2"

<400> 1037
Gly Ala Ser Thr Arg Ala Thr 
1               5           


<210> 1038
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L2"

<400> 1038
ggtgcatcta ccagggccac t                                                 21


<210> 1039
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L3"

<400> 1039
Gln Gln Tyr Ser Ser Ser Pro Leu Thr 
1               5                   


<210> 1040
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L3"

<400> 1040
cagcagtata gcagttcacc actcact                                           27


<210> 1041
<211> 363
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region"

<400> 1041
caggtgcagc tggtgcagtc tggagctgag gtgaagaagc ctggggcctc agtgaaggtc       60

tcgtgcaaga cttctggtta caccttttcc aactacggta tcagctggct gcgacaggcc      120

cctggacaag ggcttgagtg gatggcatgg atcagccctt ataatgggaa cacaaagtct      180

gcacagaggt ttcagggcag agtcatcatg accacagaca catccacgag gacagcccac      240

atggaggtga agagcctgag aactgacgac acggccacat attactgtgc gagagatcca      300

gcagtcgatg caataccgat gcttgactac tggggccagg gaaccacggt caccgtctcc      360

tca                                                                    363


<210> 1042
<211> 121
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region"

<400> 1042
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Thr Ser Gly Tyr Thr Phe Ser Asn Tyr 
            20                  25                  30          


Gly Ile Ser Trp Leu Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Ala Trp Ile Ser Pro Tyr Asn Gly Asn Thr Lys Ser Ala Gln Arg Phe 
    50                  55                  60                  


Gln Gly Arg Val Ile Met Thr Thr Asp Thr Ser Thr Arg Thr Ala His 
65                  70                  75                  80  


Met Glu Val Lys Ser Leu Arg Thr Asp Asp Thr Ala Thr Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Pro Ala Val Asp Ala Ile Pro Met Leu Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120     


<210> 1043
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H1"

<400> 1043
Tyr Thr Phe Ser Asn Tyr Gly Ile Ser 
1               5                   


<210> 1044
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H1"

<400> 1044
tacacctttt ccaactacgg tatcagc                                           27


<210> 1045
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H2"

<400> 1045
Trp Ile Ser Pro Tyr Asn Gly Asn Thr Lys Ser Ala Gln Arg Phe Gln 
1               5                   10                  15      


Gly 
    


<210> 1046
<211> 51
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H2"

<400> 1046
tggatcagcc cttataatgg gaacacaaag tctgcacaga ggtttcaggg c                51


<210> 1047
<211> 14
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H3"

<400> 1047
Ala Arg Asp Pro Ala Val Asp Ala Ile Pro Met Leu Asp Tyr 
1               5                   10                  


<210> 1048
<211> 42
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H3"

<400> 1048
gcgagagatc cagcagtcga tgcaataccg atgcttgact ac                          42


<210> 1049
<211> 336
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region"

<400> 1049
gacatccagg tgacccagtc tccactctcc ctgcccgtca cccttggaca gccggcctcc       60

atctcctgca ggtctagtca aagcctcgtg tacactgatg gaaacaccta cttgagctgg      120

tttcagcaga ggccaggcca atctccaagg cgcctaattt atagggtttc tcaccgggac      180

tctggggtcc cagacagatt caccggcagt gggtcaggca ctgatttcac actgataatc      240

cgcagggtgg aggctgagga tgttggggtt tattactgca tgcaaggtac acactggcct      300

ctcactttcg gcggagggac caaggtggaa atcaaa                                336


<210> 1050
<211> 112
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region"

<400> 1050
Asp Ile Gln Val Thr Gln Ser Pro Leu Ser Leu Pro Val Thr Leu Gly 
1               5                   10                  15      


Gln Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Val Tyr Thr 
            20                  25                  30          


Asp Gly Asn Thr Tyr Leu Ser Trp Phe Gln Gln Arg Pro Gly Gln Ser 
        35                  40                  45              


Pro Arg Arg Leu Ile Tyr Arg Val Ser His Arg Asp Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Ile Ile 
65                  70                  75                  80  


Arg Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Met Gln Gly 
                85                  90                  95      


Thr His Trp Pro Leu Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105                 110         


<210> 1051
<211> 16
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L1"

<400> 1051
Arg Ser Ser Gln Ser Leu Val Tyr Thr Asp Gly Asn Thr Tyr Leu Ser 
1               5                   10                  15      


<210> 1052
<211> 48
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L1"

<400> 1052
aggtctagtc aaagcctcgt gtacactgat ggaaacacct acttgagc                    48


<210> 1053
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L2"

<400> 1053
Arg Val Ser His Arg Asp Ser 
1               5           


<210> 1054
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L2"

<400> 1054
agggtttctc accgggactc t                                                 21


<210> 1055
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L3"

<400> 1055
Met Gln Gly Thr His Trp Pro Leu Thr 
1               5                   


<210> 1056
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L3"

<400> 1056
atgcaaggta cacactggcc tctcact                                           27


<210> 1057
<211> 351
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region"

<400> 1057
caggtccagc tggtgcagtc tgggggaggc gtggtccagc ctgggaggtc cctgagactc       60

tcctgtgcag cctctggatt cacgttcagt gactatgcca tgcactgggt ccgccaggct      120

ccaggcaagg ggctggagtg ggtggcaatc atatcatatg atgcaaataa taaatattat      180

gcagactccg tgaagggccg attcaccatc tccagagaca attccaagaa cacggtgtat      240

ctgcaaatga acagcctgag acctgaggac acggctgtat attactgtgc gaaagaagag      300

tggctggtgc cagcctactg gggccaggga atcctggtca ccgtctcctc a               351


<210> 1058
<211> 117
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region"

<400> 1058
Gln Val Gln Leu Val Gln Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp Tyr 
            20                  25                  30          


Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Ile Ile Ser Tyr Asp Ala Asn Asn Lys Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Glu Glu Trp Leu Val Pro Ala Tyr Trp Gly Gln Gly Ile Leu 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210> 1059
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H1"

<400> 1059
Phe Thr Phe Ser Asp Tyr Ala Met His 
1               5                   


<210> 1060
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H1"

<400> 1060
ttcacgttca gtgactatgc catgcac                                           27


<210> 1061
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H2"

<400> 1061
Ile Ile Ser Tyr Asp Ala Asn Asn Lys Tyr Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210> 1062
<211> 51
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H2"

<400> 1062
atcatatcat atgatgcaaa taataaatat tatgcagact ccgtgaaggg c                51


<210> 1063
<211> 10
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H3"

<400> 1063
Ala Lys Glu Glu Trp Leu Val Pro Ala Tyr 
1               5                   10  


<210> 1064
<211> 30
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H3"

<400> 1064
gcgaaagaag agtggctggt gccagcctac                                        30


<210> 1065
<211> 327
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region"

<400> 1065
cagtctgtgc tgactcagcc tgcctccgtg tctgggtctc ctggacagtc gatcaccatc       60

tcctgcactg gaaccagcag tgacgttggt ggatataatt acgtctcctg gtaccaacaa      120

cacccaggca aagcccccaa actcttaatt tatgaggtct ctaatcggcc ctcaggggtt      180

tctaatcgct tctctggctc caagtctggc aacacggcct ccctgaccat ctctgggctc      240

cagcctgagg acgaggctga ttattactgc agctcatatt caaccaatag tgcccccttt      300

ggaactggga ccaagctcac cgtccta                                          327


<210> 1066
<211> 109
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region"

<400> 1066
Gln Ser Val Leu Thr Gln Pro Ala Ser Val Ser Gly Ser Pro Gly Gln 
1               5                   10                  15      


Ser Ile Thr Ile Ser Cys Thr Gly Thr Ser Ser Asp Val Gly Gly Tyr 
            20                  25                  30          


Asn Tyr Val Ser Trp Tyr Gln Gln His Pro Gly Lys Ala Pro Lys Leu 
        35                  40                  45              


Leu Ile Tyr Glu Val Ser Asn Arg Pro Ser Gly Val Ser Asn Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Asn Thr Ala Ser Leu Thr Ile Ser Gly Leu 
65                  70                  75                  80  


Gln Pro Glu Asp Glu Ala Asp Tyr Tyr Cys Ser Ser Tyr Ser Thr Asn 
                85                  90                  95      


Ser Ala Pro Phe Gly Thr Gly Thr Lys Leu Thr Val Leu 
            100                 105                 


<210> 1067
<211> 14
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L1"

<400> 1067
Thr Gly Thr Ser Ser Asp Val Gly Gly Tyr Asn Tyr Val Ser 
1               5                   10                  


<210> 1068
<211> 42
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L1"

<400> 1068
actggaacca gcagtgacgt tggtggatat aattacgtct cc                          42


<210> 1069
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L2"

<400> 1069
Glu Val Ser Asn Arg Pro Ser 
1               5           


<210> 1070
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L2"

<400> 1070
gaggtctcta atcggccctc a                                                 21


<210> 1071
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L3"

<400> 1071
Ser Ser Tyr Ser Thr Asn Ser Ala Pro 
1               5                   


<210> 1072
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L3"

<400> 1072
agctcatatt caaccaatag tgccccc                                           27


<210> 1073
<211> 366
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region"

<400> 1073
caggtccagc ttgtgcagtc tgggggaggc gtggtccagt ctgggaggtc cctgagactc       60

tcctgtgcag cgtctggatt caccttcagt gacaatggca tgcactgggt ccgccaggct      120

ccaggcaagg ggctggagtg ggtggcagga atctttcatg atgggagtaa taaacaatat      180

gcagaatccg tgaagggccg attcatcatc tccagagaca attccaagaa cactctctat      240

ctgcaaatga acagcctgag agccgaggac acggctctat atttctgtgc gagagcccct      300

tacgatattt ggagcggata ttgtcttgac tactggggcc agggaaccct ggtcaccgtc      360

tcctca                                                                 366


<210> 1074
<211> 122
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region"

<400> 1074
Gln Val Gln Leu Val Gln Ser Gly Gly Gly Val Val Gln Ser Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp Asn 
            20                  25                  30          


Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Gly Ile Phe His Asp Gly Ser Asn Lys Gln Tyr Ala Glu Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Ile Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Leu Tyr Phe Cys 
                85                  90                  95      


Ala Arg Ala Pro Tyr Asp Ile Trp Ser Gly Tyr Cys Leu Asp Tyr Trp 
            100                 105                 110         


Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120         


<210> 1075
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H1"

<400> 1075
Phe Thr Phe Ser Asp Asn Gly Met His 
1               5                   


<210> 1076
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H1"

<400> 1076
ttcaccttca gtgacaatgg catgcac                                           27


<210> 1077
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H2"

<400> 1077
Gly Ile Phe His Asp Gly Ser Asn Lys Gln Tyr Ala Glu Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210> 1078
<211> 51
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H2"

<400> 1078
ggaatctttc atgatgggag taataaacaa tatgcagaat ccgtgaaggg c                51


<210> 1079
<211> 15
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H3"

<400> 1079
Ala Arg Ala Pro Tyr Asp Ile Trp Ser Gly Tyr Cys Leu Asp Tyr 
1               5                   10                  15  


<210> 1080
<211> 45
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H3"

<400> 1080
gcgagagccc cttacgatat ttggagcgga tattgtcttg actac                       45


<210> 1081
<211> 321
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region"

<400> 1081
gacatccgga tgacccagtc tccagccacc ctgtctctgt ctccagggga aagcgccacc       60

ctctcctgca gggccagtca gagtgttatc aacaacttag cctggtacca gcagagacct      120

ggccaggctc ccaggctcct catctatggt gcatctacca gggccactgg tatcccagcc      180

aggttcagtg gcagtgggtc tgagacagag ttcactctca ctatcagcag cctgcagtct      240

gaagatttcg cggtttatca ctgtcagcag tatagtatct ggcctcagac ttttggccag      300

gggaccaagc tggagatcaa a                                                321


<210> 1082
<211> 107
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region"

<400> 1082
Asp Ile Arg Met Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Ser Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ile Asn Asn 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Arg Pro Gly Gln Ala Pro Arg Leu Leu Ile 
        35                  40                  45              


Tyr Gly Ala Ser Thr Arg Ala Thr Gly Ile Pro Ala Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Glu Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Ser 
65                  70                  75                  80  


Glu Asp Phe Ala Val Tyr His Cys Gln Gln Tyr Ser Ile Trp Pro Gln 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210> 1083
<211> 11
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L1"

<400> 1083
Arg Ala Ser Gln Ser Val Ile Asn Asn Leu Ala 
1               5                   10      


<210> 1084
<211> 33
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L1"

<400> 1084
agggccagtc agagtgttat caacaactta gcc                                    33


<210> 1085
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L2"

<400> 1085
Gly Ala Ser Thr Arg Ala Thr 
1               5           


<210> 1086
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L2"

<400> 1086
ggtgcatcta ccagggccac t                                                 21


<210> 1087
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L3"

<400> 1087
Gln Gln Tyr Ser Ile Trp Pro Gln Thr 
1               5                   


<210> 1088
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L3"

<400> 1088
cagcagtata gtatctggcc tcagact                                           27


<210> 1089
<211> 366
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region"

<400> 1089
gaggtgcagc tgttggagtc cgggggaggc gtggtccagt ctgggaggtc cctgagactc       60

tcctgtgtag cgtctggatt caccttcagt gacagtggca tgcactgggt ccgccaggct      120

ccaggcaagg ggctggagtg ggtggcaggt ttattttatg atggaagtaa taaacaatat      180

gcagactccg tgaagggccg attcaccatc tccagagaca attccaagag cacactgtat      240

ctgcagatga acagcctgag ggccgaggac acggctgttt attactgtgc gagagcccct      300

tacgatattt ggagtggtta ttgtcttgac tactggggcc agggaaccct ggtcactgtc      360

tcctca                                                                 366


<210> 1090
<211> 122
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region"

<400> 1090
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Val Val Gln Ser Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Val Ala Ser Gly Phe Thr Phe Ser Asp Ser 
            20                  25                  30          


Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Gly Leu Phe Tyr Asp Gly Ser Asn Lys Gln Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Ser Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ala Pro Tyr Asp Ile Trp Ser Gly Tyr Cys Leu Asp Tyr Trp 
            100                 105                 110         


Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120         


<210> 1091
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H1"

<400> 1091
Phe Thr Phe Ser Asp Ser Gly Met His 
1               5                   


<210> 1092
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H1"

<400> 1092
ttcaccttca gtgacagtgg catgcac                                           27


<210> 1093
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H2"

<400> 1093
Gly Leu Phe Tyr Asp Gly Ser Asn Lys Gln Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210> 1094
<211> 51
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H2"

<400> 1094
ggtttatttt atgatggaag taataaacaa tatgcagact ccgtgaaggg c                51


<210> 1095
<211> 15
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H3"

<400> 1095
Ala Arg Ala Pro Tyr Asp Ile Trp Ser Gly Tyr Cys Leu Asp Tyr 
1               5                   10                  15  


<210> 1096
<211> 45
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H3"

<400> 1096
gcgagagccc cttacgatat ttggagtggt tattgtcttg actac                       45


<210> 1097
<211> 321
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region"

<400> 1097
gaaattgtat tgacacagtc tccagccacc ctgtatatgt ctccagggga aagagccacc       60

ctctcctgca gggccagtca gagtgttaac aacaacttag cctggtacca gcagagacct      120

ggccaggctc ccaggctcct catctatggt gcatctacca gggccactgg tatcccagcc      180

aggttcagtg gcagtgggtc tgagacagag ttcactctca ctatcagcag cctgcagtct      240

gaagattttg cggtttatca ctgtcagcag tatagtatct ggcctcagac ttttggccag      300

gggaccaagc tggagatcaa a                                                321


<210> 1098
<211> 107
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region"

<400> 1098
Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Tyr Met Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Asn Asn Asn 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Arg Pro Gly Gln Ala Pro Arg Leu Leu Ile 
        35                  40                  45              


Tyr Gly Ala Ser Thr Arg Ala Thr Gly Ile Pro Ala Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Glu Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Ser 
65                  70                  75                  80  


Glu Asp Phe Ala Val Tyr His Cys Gln Gln Tyr Ser Ile Trp Pro Gln 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210> 1099
<211> 11
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L1"

<400> 1099
Arg Ala Ser Gln Ser Val Asn Asn Asn Leu Ala 
1               5                   10      


<210> 1100
<211> 33
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L1"

<400> 1100
agggccagtc agagtgttaa caacaactta gcc                                    33


<210> 1101
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L2"

<400> 1101
Gly Ala Ser Thr Arg Ala Thr 
1               5           


<210> 1102
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L2"

<400> 1102
ggtgcatcta ccagggccac t                                                 21


<210> 1103
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L3"

<400> 1103
Gln Gln Tyr Ser Ile Trp Pro Gln Thr 
1               5                   


<210> 1104
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L3"

<400> 1104
cagcagtata gtatctggcc tcagact                                           27


<210> 1105
<211> 363
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region"

<400> 1105
caggtccagc tggtgcagtc tggagctgag gtgaagaagc ctggggcctc agtgaaggtc       60

tcgtgcaaga cttctggtta caccttttcc aactacggta tcagctggct gcgacaggcc      120

cctggacaag ggcttgagtg gatggcatgg atcagccctt ataatgggaa cacaaagtct      180

gcacagaggt ttcagggcag agtcatcatg accacagaca catccacgag gacagcccac      240

atggaggtga agagcctgag aactgacgac acggccacat attactgtgc gagagatcca      300

gcagtcgatg caataccgat gcttgactac tggggccagg gaaccatggt caccgtctcc      360

tca                                                                    363


<210> 1106
<211> 121
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region"

<400> 1106
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Thr Ser Gly Tyr Thr Phe Ser Asn Tyr 
            20                  25                  30          


Gly Ile Ser Trp Leu Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Ala Trp Ile Ser Pro Tyr Asn Gly Asn Thr Lys Ser Ala Gln Arg Phe 
    50                  55                  60                  


Gln Gly Arg Val Ile Met Thr Thr Asp Thr Ser Thr Arg Thr Ala His 
65                  70                  75                  80  


Met Glu Val Lys Ser Leu Arg Thr Asp Asp Thr Ala Thr Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Pro Ala Val Asp Ala Ile Pro Met Leu Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Met Val Thr Val Ser Ser 
        115                 120     


<210> 1107
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H1"

<400> 1107
Tyr Thr Phe Ser Asn Tyr Gly Ile Ser 
1               5                   


<210> 1108
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H1"

<400> 1108
tacacctttt ccaactacgg tatcagc                                           27


<210> 1109
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H2"

<400> 1109
Trp Ile Ser Pro Tyr Asn Gly Asn Thr Lys Ser Ala Gln Arg Phe Gln 
1               5                   10                  15      


Gly 
    


<210> 1110
<211> 51
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H2"

<400> 1110
tggatcagcc cttataatgg gaacacaaag tctgcacaga ggtttcaggg c                51


<210> 1111
<211> 14
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H3"

<400> 1111
Ala Arg Asp Pro Ala Val Asp Ala Ile Pro Met Leu Asp Tyr 
1               5                   10                  


<210> 1112
<211> 42
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H3"

<400> 1112
gcgagagatc cagcagtcga tgcaataccg atgcttgact ac                          42


<210> 1113
<211> 336
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region"

<400> 1113
gaaattgtgt tgacacagtc tccactctcc ctgcccgtca cccttggaca gccggcctcc       60

atctcctgca ggtctagtca aagcctcgtg tacactgatg gaaacaccta cttgagctgg      120

tttcagcaga ggccaggcca atctccaagg cgcctaattt atagggtttc tcaccgggac      180

tctggggtcc cagacagatt caccggcagt gggtcaggca ctgatttcac actgataatc      240

cgcagggtgg aggctgagga tgttggggtt tattactgca tgcaaggtac acactggcct      300

ctcactttcg gcggagggac caaggtggaa atcaaa                                336


<210> 1114
<211> 112
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region"

<400> 1114
Glu Ile Val Leu Thr Gln Ser Pro Leu Ser Leu Pro Val Thr Leu Gly 
1               5                   10                  15      


Gln Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Val Tyr Thr 
            20                  25                  30          


Asp Gly Asn Thr Tyr Leu Ser Trp Phe Gln Gln Arg Pro Gly Gln Ser 
        35                  40                  45              


Pro Arg Arg Leu Ile Tyr Arg Val Ser His Arg Asp Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Ile Ile 
65                  70                  75                  80  


Arg Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Met Gln Gly 
                85                  90                  95      


Thr His Trp Pro Leu Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105                 110         


<210> 1115
<211> 16
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L1"

<400> 1115
Arg Ser Ser Gln Ser Leu Val Tyr Thr Asp Gly Asn Thr Tyr Leu Ser 
1               5                   10                  15      


<210> 1116
<211> 48
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L1"

<400> 1116
aggtctagtc aaagcctcgt gtacactgat ggaaacacct acttgagc                    48


<210> 1117
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L2"

<400> 1117
Arg Val Ser His Arg Asp Ser 
1               5           


<210> 1118
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L2"

<400> 1118
agggtttctc accgggactc t                                                 21


<210> 1119
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L3"

<400> 1119
Met Gln Gly Thr His Trp Pro Leu Thr 
1               5                   


<210> 1120
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L3"

<400> 1120
atgcaaggta cacactggcc tctcact                                           27


<210> 1121
<211> 348
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region"

<400> 1121
gaggtgcagc tggtggagtc gggcccaaga ctggtgaggc cttcggagac cctgtccctc       60

acctgcactg tctctggagg cttcatcaaa actagtagtt actactgggg ctggatccgt      120

cagcccccag ggaaggggct agagtggatt gggagtatct attatgctgg gaccacctac      180

tacaacccgt ccctccagag tcgagtcacc atgtccgttg acacgtcgaa caaccagttc      240

tccctgaagc tgaactctgt gaccgccgca gacacggctg tatattactg tgcgaccgcc      300

tggacttttg accactgggg ccagggaacc ctggtcactg tctcctca                   348


<210> 1122
<211> 116
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region"

<400> 1122
Glu Val Gln Leu Val Glu Ser Gly Pro Arg Leu Val Arg Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Gly Phe Ile Lys Thr Ser 
            20                  25                  30          


Ser Tyr Tyr Trp Gly Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu 
        35                  40                  45              


Trp Ile Gly Ser Ile Tyr Tyr Ala Gly Thr Thr Tyr Tyr Asn Pro Ser 
    50                  55                  60                  


Leu Gln Ser Arg Val Thr Met Ser Val Asp Thr Ser Asn Asn Gln Phe 
65                  70                  75                  80  


Ser Leu Lys Leu Asn Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr 
                85                  90                  95      


Cys Ala Thr Ala Trp Thr Phe Asp His Trp Gly Gln Gly Thr Leu Val 
            100                 105                 110         


Thr Val Ser Ser 
        115     


<210> 1123
<211> 11
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H1"

<400> 1123
Gly Phe Ile Lys Thr Ser Ser Tyr Tyr Trp Gly 
1               5                   10      


<210> 1124
<211> 33
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H1"

<400> 1124
ggcttcatca aaactagtag ttactactgg ggc                                    33


<210> 1125
<211> 16
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H2"

<400> 1125
Ser Ile Tyr Tyr Ala Gly Thr Thr Tyr Tyr Asn Pro Ser Leu Gln Ser 
1               5                   10                  15      


<210> 1126
<211> 48
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H2"

<400> 1126
agtatctatt atgctgggac cacctactac aacccgtccc tccagagt                    48


<210> 1127
<211> 8
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H3"

<400> 1127
Ala Thr Ala Trp Thr Phe Asp His 
1               5               


<210> 1128
<211> 24
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H3"

<400> 1128
gcgaccgcct ggacttttga ccac                                              24


<210> 1129
<211> 327
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region"

<400> 1129
gaaattgtat tgacacagtc tccagccacc ctgtccttgt ctccagggga aagagccacc       60

ctctcctgca gggccagtca gagtcttagc aactacttag cctggtacca acagaaacct      120

ggccaggctc ccaggctcct catctatgat gcatccaaca gggccactgg catcccagcc      180

aggttcagtg gcagtgggtc tgggacagac ttcactctca ccatcagcag cctagagcct      240

gaagattttg cagtttatta ctgtcagctg cgtggccact ggccccccac gatcaccttc      300

ggccaaggga cacgactgga gattaaa                                          327


<210> 1130
<211> 109
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region"

<400> 1130
Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Leu Ser Asn Tyr 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 
        35                  40                  45              


Tyr Asp Ala Ser Asn Arg Ala Thr Gly Ile Pro Ala Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Val Tyr Tyr Cys Gln Leu Arg Gly His Trp Pro Pro 
                85                  90                  95      


Thr Ile Thr Phe Gly Gln Gly Thr Arg Leu Glu Ile Lys 
            100                 105                 


<210> 1131
<211> 11
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L1"

<400> 1131
Arg Ala Ser Gln Ser Leu Ser Asn Tyr Leu Ala 
1               5                   10      


<210> 1132
<211> 33
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L1"

<400> 1132
agggccagtc agagtcttag caactactta gcc                                    33


<210> 1133
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L2"

<400> 1133
Asp Ala Ser Asn Arg Ala Thr 
1               5           


<210> 1134
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L2"

<400> 1134
gatgcatcca acagggccac t                                                 21


<210> 1135
<211> 11
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L3"

<400> 1135
Gln Leu Arg Gly His Trp Pro Pro Thr Ile Thr 
1               5                   10      


<210> 1136
<211> 33
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L3"

<400> 1136
cagctgcgtg gccactggcc ccccacgatc acc                                    33


<210> 1137
<211> 369
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region"

<400> 1137
caggtccagc ttgtacagtc tgggggaggc ttggttcagc cgggggggtc cctgagactc       60

tcctgtgcag cctctggatt cgcctttagc gactatacca tgagctgggt ccgccaggct      120

ccagggaagg ggctggagtg ggtctcaagt gttagtggca cgggtggtac ctcatactac      180

gcagactccg tgaatggccg gttcgccatc tccagagaga attccaagaa cacgctgttt      240

ctgcaaatgg acagcctgag agccgaggac acggccactt actactgtgc caaagatggg      300

ttgagggacg tatcgagggt ttattacatc gacgtctggg gcaaagggac cacggtcacc      360

gtctcctca                                                              369


<210> 1138
<211> 123
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region"

<400> 1138
Gln Val Gln Leu Val Gln Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ala Phe Ser Asp Tyr 
            20                  25                  30          


Thr Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ser Val Ser Gly Thr Gly Gly Thr Ser Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Asn Gly Arg Phe Ala Ile Ser Arg Glu Asn Ser Lys Asn Thr Leu Phe 
65                  70                  75                  80  


Leu Gln Met Asp Ser Leu Arg Ala Glu Asp Thr Ala Thr Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Asp Gly Leu Arg Asp Val Ser Arg Val Tyr Tyr Ile Asp Val 
            100                 105                 110         


Trp Gly Lys Gly Thr Thr Val Thr Val Ser Ser 
        115                 120             


<210> 1139
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H1"

<400> 1139
Phe Ala Phe Ser Asp Tyr Thr Met Ser 
1               5                   


<210> 1140
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H1"

<400> 1140
ttcgccttta gcgactatac catgagc                                           27


<210> 1141
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H2"

<400> 1141
Ser Val Ser Gly Thr Gly Gly Thr Ser Tyr Tyr Ala Asp Ser Val Asn 
1               5                   10                  15      


Gly 
    


<210> 1142
<211> 51
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H2"

<400> 1142
agtgttagtg gcacgggtgg tacctcatac tacgcagact ccgtgaatgg c                51


<210> 1143
<211> 16
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H3"

<400> 1143
Ala Lys Asp Gly Leu Arg Asp Val Ser Arg Val Tyr Tyr Ile Asp Val 
1               5                   10                  15      


<210> 1144
<211> 48
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H3"

<400> 1144
gccaaagatg ggttgaggga cgtatcgagg gtttattaca tcgacgtc                    48


<210> 1145
<211> 333
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region"

<400> 1145
cagcctgtgc tgactcagcc tgcctccgtg tctgggtctc ctggacagtc gatcaccatc       60

tcctgcactg gaaccagccg tgacattggt tctcatgact ctgtctcctg gtaccaacaa      120

aagccaggca aagcccccaa actcatcatt tatgcagtca gaaatcggcc ctcagggctt      180

tctaatcgct tctctggttc caagtctggc aacacggcct ccctgaccat ctctgggctc      240

cagactgaag acgaaggtga ctattactgc agctcatata gaaacggcaa cgctctgggg      300

gtcttcggaa ctgggaccaa ggtcaccgtc ctc                                   333


<210> 1146
<211> 111
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region"

<400> 1146
Gln Pro Val Leu Thr Gln Pro Ala Ser Val Ser Gly Ser Pro Gly Gln 
1               5                   10                  15      


Ser Ile Thr Ile Ser Cys Thr Gly Thr Ser Arg Asp Ile Gly Ser His 
            20                  25                  30          


Asp Ser Val Ser Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu 
        35                  40                  45              


Ile Ile Tyr Ala Val Arg Asn Arg Pro Ser Gly Leu Ser Asn Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Asn Thr Ala Ser Leu Thr Ile Ser Gly Leu 
65                  70                  75                  80  


Gln Thr Glu Asp Glu Gly Asp Tyr Tyr Cys Ser Ser Tyr Arg Asn Gly 
                85                  90                  95      


Asn Ala Leu Gly Val Phe Gly Thr Gly Thr Lys Val Thr Val Leu 
            100                 105                 110     


<210> 1147
<211> 14
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L1"

<400> 1147
Thr Gly Thr Ser Arg Asp Ile Gly Ser His Asp Ser Val Ser 
1               5                   10                  


<210> 1148
<211> 42
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L1"

<400> 1148
actggaacca gccgtgacat tggttctcat gactctgtct cc                          42


<210> 1149
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L2"

<400> 1149
Ala Val Arg Asn Arg Pro Ser 
1               5           


<210> 1150
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L2"

<400> 1150
gcagtcagaa atcggccctc a                                                 21


<210> 1151
<211> 11
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L3"

<400> 1151
Ser Ser Tyr Arg Asn Gly Asn Ala Leu Gly Val 
1               5                   10      


<210> 1152
<211> 33
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L3"

<400> 1152
agctcatata gaaacggcaa cgctctgggg gtc                                    33


<210> 1153
<211> 369
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region"

<400> 1153
caggtgcagc tggtggagtc tgggggaggc ttggttcagc cgggggggtc cctgagactc       60

tcctgtgcag cctctggatt cgcctttagc aactatgcca tgagctgggt ccgccaggct      120

ccagggaagg gcctggagtg ggtctcaagt gttagtggca cgggtggtac cacatactac      180

gcagactccg tgaacgggcg gttcgccatc tccagagaga attccaggaa caccctctat      240

ctgcaaatgg atagcctgag agtcgaggac acggccactt attactgtgc caaagatggg      300

ttgagggact tatcgagggt ctattacatc gacgtctggg gcaaaggggc cacggtcacc      360

gtctcttca                                                              369


<210> 1154
<211> 123
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region"

<400> 1154
Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ala Phe Ser Asn Tyr 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ser Val Ser Gly Thr Gly Gly Thr Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Asn Gly Arg Phe Ala Ile Ser Arg Glu Asn Ser Arg Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asp Ser Leu Arg Val Glu Asp Thr Ala Thr Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Asp Gly Leu Arg Asp Leu Ser Arg Val Tyr Tyr Ile Asp Val 
            100                 105                 110         


Trp Gly Lys Gly Ala Thr Val Thr Val Ser Ser 
        115                 120             


<210> 1155
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H1"

<400> 1155
Phe Ala Phe Ser Asn Tyr Ala Met Ser 
1               5                   


<210> 1156
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H1"

<400> 1156
ttcgccttta gcaactatgc catgagc                                           27


<210> 1157
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H2"

<400> 1157
Ser Val Ser Gly Thr Gly Gly Thr Thr Tyr Tyr Ala Asp Ser Val Asn 
1               5                   10                  15      


Gly 
    


<210> 1158
<211> 51
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H2"

<400> 1158
agtgttagtg gcacgggtgg taccacatac tacgcagact ccgtgaacgg g                51


<210> 1159
<211> 16
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H3"

<400> 1159
Ala Lys Asp Gly Leu Arg Asp Leu Ser Arg Val Tyr Tyr Ile Asp Val 
1               5                   10                  15      


<210> 1160
<211> 48
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H3"

<400> 1160
gccaaagatg ggttgaggga cttatcgagg gtctattaca tcgacgtc                    48


<210> 1161
<211> 333
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region"

<400> 1161
cagtctgtcc tgactcagcc tgcctccgtg tctgggtctc ctggacagtc gatcaccatc       60

tcctgcactg gaaccagccg tgacattggt agtcatgact atgtctcctg gtaccaacaa      120

cacccaggca aagcccccaa actcatcatt tatggggtca ataatcggcc ctcaggactt      180

tctaatcgct tctctggttc caagtctggc aacacggcct ccctgaccat ctctgggctc      240

cagactgaag acgaaggtga ctattactgc agctcatata gaaacggcaa cactctgggg      300

gtcttcggaa ctgggaccaa gctcaccgtc cta                                   333


<210> 1162
<211> 111
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region"

<400> 1162
Gln Ser Val Leu Thr Gln Pro Ala Ser Val Ser Gly Ser Pro Gly Gln 
1               5                   10                  15      


Ser Ile Thr Ile Ser Cys Thr Gly Thr Ser Arg Asp Ile Gly Ser His 
            20                  25                  30          


Asp Tyr Val Ser Trp Tyr Gln Gln His Pro Gly Lys Ala Pro Lys Leu 
        35                  40                  45              


Ile Ile Tyr Gly Val Asn Asn Arg Pro Ser Gly Leu Ser Asn Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Asn Thr Ala Ser Leu Thr Ile Ser Gly Leu 
65                  70                  75                  80  


Gln Thr Glu Asp Glu Gly Asp Tyr Tyr Cys Ser Ser Tyr Arg Asn Gly 
                85                  90                  95      


Asn Thr Leu Gly Val Phe Gly Thr Gly Thr Lys Leu Thr Val Leu 
            100                 105                 110     


<210> 1163
<211> 14
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L1"

<400> 1163
Thr Gly Thr Ser Arg Asp Ile Gly Ser His Asp Tyr Val Ser 
1               5                   10                  


<210> 1164
<211> 42
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L1"

<400> 1164
actggaacca gccgtgacat tggtagtcat gactatgtct cc                          42


<210> 1165
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L2"

<400> 1165
Gly Val Asn Asn Arg Pro Ser 
1               5           


<210> 1166
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L2"

<400> 1166
ggggtcaata atcggccctc a                                                 21


<210> 1167
<211> 11
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L3"

<400> 1167
Ser Ser Tyr Arg Asn Gly Asn Thr Leu Gly Val 
1               5                   10      


<210> 1168
<211> 33
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L3"

<400> 1168
agctcatata gaaacggcaa cactctgggg gtc                                    33


<210> 1169
<211> 375
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region"

<400> 1169
caggtccagc tggtacagtc tggggctgag gtgaagaagc ctgggtcctc ggtgaaggtc       60

tcctgcaagg cctctggagg caccttcagc ggctacgcta tcaactgggt gcgacaggcc      120

cctggacaag ggctcgagtg gatgggaggg atcatccata tatttgggac agtaaactac      180

gctccgaagt tccagggcag actcacgata accgcggacg catccacggg cacagcctac      240

atggaattga gcagcctgat gtctgaggac acggccctat attattgtgc gagagatgct      300

tacgaagtgt ggaccggttc ttatctcccc ccttttgact actggggcca gggaaccctg      360

gtcaccgtct cctca                                                       375


<210> 1170
<211> 125
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region"

<400> 1170
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Gly Tyr 
            20                  25                  30          


Ala Ile Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Gly Ile Ile His Ile Phe Gly Thr Val Asn Tyr Ala Pro Lys Phe 
    50                  55                  60                  


Gln Gly Arg Leu Thr Ile Thr Ala Asp Ala Ser Thr Gly Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Met Ser Glu Asp Thr Ala Leu Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Ala Tyr Glu Val Trp Thr Gly Ser Tyr Leu Pro Pro Phe 
            100                 105                 110         


Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125 


<210> 1171
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H1"

<400> 1171
Gly Thr Phe Ser Gly Tyr Ala Ile Asn 
1               5                   


<210> 1172
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H1"

<400> 1172
ggcaccttca gcggctacgc tatcaac                                           27


<210> 1173
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H2"

<400> 1173
Gly Ile Ile His Ile Phe Gly Thr Val Asn Tyr Ala Pro Lys Phe Gln 
1               5                   10                  15      


Gly 
    


<210> 1174
<211> 51
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H2"

<400> 1174
gggatcatcc atatatttgg gacagtaaac tacgctccga agttccaggg c                51


<210> 1175
<211> 18
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H3"

<400> 1175
Ala Arg Asp Ala Tyr Glu Val Trp Thr Gly Ser Tyr Leu Pro Pro Phe 
1               5                   10                  15      


Asp Tyr 
        


<210> 1176
<211> 54
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H3"

<400> 1176
gcgagagatg cttacgaagt gtggaccggt tcttatctcc ccccttttga ctac             54


<210> 1177
<211> 324
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region"

<400> 1177
gaaacgacac tcacgcagtc tccaggcacc ctgtctttgt ctcccgggga aagagtcacc       60

ctctcctgca gggccagtca gactgttaca agcaactact tagcctggta ccagcagaaa      120

cctggccagg ctcccaggct cctcatctat gatgcattca ccagggccac tggcgtccca      180

gccaggttca gtggcagtgg gtctgggaca gacttcactc tcaccatcag cagactggag      240

cctgaagatt ttgcagttta ctattgtcag cagtatggta gctcattcct cactttcggc      300

ggagggacca aggtggaaat caaa                                             324


<210> 1178
<211> 108
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region"

<400> 1178
Glu Thr Thr Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Val Thr Leu Ser Cys Arg Ala Ser Gln Thr Val Thr Ser Asn 
            20                  25                  30          


Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu 
        35                  40                  45              


Ile Tyr Asp Ala Phe Thr Arg Ala Thr Gly Val Pro Ala Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu 
65                  70                  75                  80  


Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Gly Ser Ser Phe 
                85                  90                  95      


Leu Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105             


<210> 1179
<211> 12
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L1"

<400> 1179
Arg Ala Ser Gln Thr Val Thr Ser Asn Tyr Leu Ala 
1               5                   10          


<210> 1180
<211> 36
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L1"

<400> 1180
agggccagtc agactgttac aagcaactac ttagcc                                 36


<210> 1181
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L2"

<400> 1181
Asp Ala Phe Thr Arg Ala Thr 
1               5           


<210> 1182
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L2"

<400> 1182
gatgcattca ccagggccac t                                                 21


<210> 1183
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L3"

<400> 1183
Gln Gln Tyr Gly Ser Ser Phe Leu Thr 
1               5                   


<210> 1184
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L3"

<400> 1184
cagcagtatg gtagctcatt cctcact                                           27


<210> 1185
<211> 366
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region"

<400> 1185
gaggtgcagc tggtggagtc tgggggaggc gtggtccagt ctgggaggtc cctgagactc       60

tcctgtgcag catctggatt catcttcagt gacaatggca tgcactgggt ccgccaggct      120

ccaggcaagg ggctggagtg ggtggcaggt attttttatg atggaagtaa taaacaatat      180

gcagactccg tgaagggccg attcaccatc tccagagaca attccaagaa cacactgtat      240

ctgcaaatga agagcctgag agccgaggac acggctgtgt attactgtgc gagagcccct      300

tacgatatct ggagtggtta ttgtcttgac tactggggcc agggaaccct ggtcaccgtc      360

tcctca                                                                 366


<210> 1186
<211> 122
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region"

<400> 1186
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Ser Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ile Phe Ser Asp Asn 
            20                  25                  30          


Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Gly Ile Phe Tyr Asp Gly Ser Asn Lys Gln Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Lys Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ala Pro Tyr Asp Ile Trp Ser Gly Tyr Cys Leu Asp Tyr Trp 
            100                 105                 110         


Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120         


<210> 1187
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H1"

<400> 1187
Phe Ile Phe Ser Asp Asn Gly Met His 
1               5                   


<210> 1188
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H1"

<400> 1188
ttcatcttca gtgacaatgg catgcac                                           27


<210> 1189
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H2"

<400> 1189
Gly Ile Phe Tyr Asp Gly Ser Asn Lys Gln Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210> 1190
<211> 51
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H2"

<400> 1190
ggtatttttt atgatggaag taataaacaa tatgcagact ccgtgaaggg c                51


<210> 1191
<211> 15
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H3"

<400> 1191
Ala Arg Ala Pro Tyr Asp Ile Trp Ser Gly Tyr Cys Leu Asp Tyr 
1               5                   10                  15  


<210> 1192
<211> 45
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H3"

<400> 1192
gcgagagccc cttacgatat ctggagtggt tattgtcttg actac                       45


<210> 1193
<211> 321
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region"

<400> 1193
gacatccagg tgacccagtc tccagccacc ctgtctatgt ctccagggga aagagccacc       60

ctctcctgca gggccagtca gagtgttaac aacaacttag cctggtacca gcagagacct      120

ggccaggctc ccaggctcct catctatggt gcatctacga gggccactgg tatcccagcc      180

aggttcagtg gcagtgggtc tgagacagag ttcactctca ctatcagcag cctgcagtct      240

gaagattttg cggtttatca ctgtcagcag tatagtatct ggcctcagac ttttggccag      300

gggaccaagg tggaaatcaa a                                                321


<210> 1194
<211> 107
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region"

<400> 1194
Asp Ile Gln Val Thr Gln Ser Pro Ala Thr Leu Ser Met Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Asn Asn Asn 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Arg Pro Gly Gln Ala Pro Arg Leu Leu Ile 
        35                  40                  45              


Tyr Gly Ala Ser Thr Arg Ala Thr Gly Ile Pro Ala Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Glu Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Ser 
65                  70                  75                  80  


Glu Asp Phe Ala Val Tyr His Cys Gln Gln Tyr Ser Ile Trp Pro Gln 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210> 1195
<211> 11
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L1"

<400> 1195
Arg Ala Ser Gln Ser Val Asn Asn Asn Leu Ala 
1               5                   10      


<210> 1196
<211> 33
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L1"

<400> 1196
agggccagtc agagtgttaa caacaactta gcc                                    33


<210> 1197
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L2"

<400> 1197
Gly Ala Ser Thr Arg Ala Thr 
1               5           


<210> 1198
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L2"

<400> 1198
ggtgcatcta cgagggccac t                                                 21


<210> 1199
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L3"

<400> 1199
Gln Gln Tyr Ser Ile Trp Pro Gln Thr 
1               5                   


<210> 1200
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L3"

<400> 1200
cagcagtata gtatctggcc tcagact                                           27


<210> 1201
<211> 360
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region"

<400> 1201
caggtccagc ttgtacagtc tggggctgaa ctaaagaagc ctggctcctc ggtgaaagtc       60

tcctgcaagg cttctgcaga caccttcaaa agttatgcta tcaactgggt gcggcaggcc      120

cctggacaag gacttgagtg gatgggagag ttcatcccaa tctttggtgt ctcaccctcc      180

gcacagaagt tccagggcag agtcaccatt accgcggaca gatccacgtc cacagcctac      240

atggagttga gcagcctgaa atctgatgac tcggccattt attactgtgc gacacgtctg      300

tatacgttgg ggtccccttt tgacaattgg ggccagggga ccacggtcac cgtctcctca      360


<210> 1202
<211> 120
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region"

<400> 1202
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Leu Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Ala Asp Thr Phe Lys Ser Tyr 
            20                  25                  30          


Ala Ile Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Glu Phe Ile Pro Ile Phe Gly Val Ser Pro Ser Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Ala Asp Arg Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Lys Ser Asp Asp Ser Ala Ile Tyr Tyr Cys 
                85                  90                  95      


Ala Thr Arg Leu Tyr Thr Leu Gly Ser Pro Phe Asp Asn Trp Gly Gln 
            100                 105                 110         


Gly Thr Thr Val Thr Val Ser Ser 
        115                 120 


<210> 1203
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H1"

<400> 1203
Asp Thr Phe Lys Ser Tyr Ala Ile Asn 
1               5                   


<210> 1204
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H1"

<400> 1204
gacaccttca aaagttatgc tatcaac                                           27


<210> 1205
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H2"

<400> 1205
Glu Phe Ile Pro Ile Phe Gly Val Ser Pro Ser Ala Gln Lys Phe Gln 
1               5                   10                  15      


Gly 
    


<210> 1206
<211> 51
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H2"

<400> 1206
gagttcatcc caatctttgg tgtctcaccc tccgcacaga agttccaggg c                51


<210> 1207
<211> 13
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H3"

<400> 1207
Ala Thr Arg Leu Tyr Thr Leu Gly Ser Pro Phe Asp Asn 
1               5                   10              


<210> 1208
<211> 39
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H3"

<400> 1208
gcgacacgtc tgtatacgtt ggggtcccct tttgacaat                              39


<210> 1209
<211> 330
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region"

<400> 1209
cagcctgtgc tgactcagcc tcgctcagtg tccgggtctc ctggacagtc agtcaccatc       60

tcctgcactg gaaccagtag tgatgttggt gattatgact atgtctcctg gtaccaacac      120

ctcccaggcg aagtccccaa actcatagtt tataatgtca ttaagcggcc ctctggggtc      180

cctgatcgct tctctggctc caagtctggc aacacggcct ccctgaccat ctctgggctc      240

caggctgagg atgaggctga ctattactgc tgctcatatg caggcaggta tatttatgtc      300

ttcggcagtg ggaccaagct caccgtccta                                       330


<210> 1210
<211> 110
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region"

<400> 1210
Gln Pro Val Leu Thr Gln Pro Arg Ser Val Ser Gly Ser Pro Gly Gln 
1               5                   10                  15      


Ser Val Thr Ile Ser Cys Thr Gly Thr Ser Ser Asp Val Gly Asp Tyr 
            20                  25                  30          


Asp Tyr Val Ser Trp Tyr Gln His Leu Pro Gly Glu Val Pro Lys Leu 
        35                  40                  45              


Ile Val Tyr Asn Val Ile Lys Arg Pro Ser Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Asn Thr Ala Ser Leu Thr Ile Ser Gly Leu 
65                  70                  75                  80  


Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Cys Ser Tyr Ala Gly Arg 
                85                  90                  95      


Tyr Ile Tyr Val Phe Gly Ser Gly Thr Lys Leu Thr Val Leu 
            100                 105                 110 


<210> 1211
<211> 14
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L1"

<400> 1211
Thr Gly Thr Ser Ser Asp Val Gly Asp Tyr Asp Tyr Val Ser 
1               5                   10                  


<210> 1212
<211> 42
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L1"

<400> 1212
actggaacca gtagtgatgt tggtgattat gactatgtct cc                          42


<210> 1213
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L2"

<400> 1213
Asn Val Ile Lys Arg Pro Ser 
1               5           


<210> 1214
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L2"

<400> 1214
aatgtcatta agcggccctc t                                                 21


<210> 1215
<211> 10
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L3"

<400> 1215
Cys Ser Tyr Ala Gly Arg Tyr Ile Tyr Val 
1               5                   10  


<210> 1216
<211> 30
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L3"

<400> 1216
tgctcatatg caggcaggta tatttatgtc                                        30


<210> 1217
<211> 375
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region"

<400> 1217
gaggtgcagc tgttggagtc tgggggaggc ctggtcaagc ctggggagtc cctgagactc       60

tcctgtgcag cctctggatt cacccttagt ggctactaca tgaattgggt ccgccaggct      120

ccagggaggg ggctggagtg ggtctcctcc attagtggtg gtagtaatta cataaactac      180

gccgactcag tgaagggccg gttcaccatc tccagagaca acgccaagaa ctcactctat      240

ctgcaaatga acagcctgag agtcgaggac acggctgtct attactgtgc gagggtccac      300

gtggatttag tgactacgat ttttggggtt gactttgact tctggggcca gggaaccctg      360

gtcactgtct cctca                                                       375


<210> 1218
<211> 125
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region"

<400> 1218
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Glu 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Leu Ser Gly Tyr 
            20                  25                  30          


Tyr Met Asn Trp Val Arg Gln Ala Pro Gly Arg Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ser Ile Ser Gly Gly Ser Asn Tyr Ile Asn Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Val Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Val His Val Asp Leu Val Thr Thr Ile Phe Gly Val Asp Phe 
            100                 105                 110         


Asp Phe Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125 


<210> 1219
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H1"

<400> 1219
Phe Thr Leu Ser Gly Tyr Tyr Met Asn 
1               5                   


<210> 1220
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H1"

<400> 1220
ttcaccctta gtggctacta catgaat                                           27


<210> 1221
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H2"

<400> 1221
Ser Ile Ser Gly Gly Ser Asn Tyr Ile Asn Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210> 1222
<211> 51
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H2"

<400> 1222
tccattagtg gtggtagtaa ttacataaac tacgccgact cagtgaaggg c                51


<210> 1223
<211> 18
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H3"

<400> 1223
Ala Arg Val His Val Asp Leu Val Thr Thr Ile Phe Gly Val Asp Phe 
1               5                   10                  15      


Asp Phe 
        


<210> 1224
<211> 54
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H3"

<400> 1224
gcgagggtcc acgtggattt agtgactacg atttttgggg ttgactttga cttc             54


<210> 1225
<211> 333
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region"

<400> 1225
cagtctgtgc tgacgcagcc gccctcagtg tctggggccc cagggcagag ggtcaccatc       60

tcctgcactg ggagcagctc caacatcggg gcagggtatg atgtacactg gtaccagcaa      120

cttccaggaa cagcccccaa actcctcatc tatggtaaca ccaatcggcc cgcaggggtc      180

cctgaccgat tctctggctc caagtctggc tcctcagcct ccctggccat cactgggctc      240

caggctgagg atgaggctga ttattactgc cagtcgtatg acagcagcct gagtggtgcg      300

atcttcggcg gagggaccaa gctcaccgtc cta                                   333


<210> 1226
<211> 111
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region"

<400> 1226
Gln Ser Val Leu Thr Gln Pro Pro Ser Val Ser Gly Ala Pro Gly Gln 
1               5                   10                  15      


Arg Val Thr Ile Ser Cys Thr Gly Ser Ser Ser Asn Ile Gly Ala Gly 
            20                  25                  30          


Tyr Asp Val His Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu 
        35                  40                  45              


Leu Ile Tyr Gly Asn Thr Asn Arg Pro Ala Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Ser Ser Ala Ser Leu Ala Ile Thr Gly Leu 
65                  70                  75                  80  


Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Gln Ser Tyr Asp Ser Ser 
                85                  90                  95      


Leu Ser Gly Ala Ile Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 110     


<210> 1227
<211> 14
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L1"

<400> 1227
Thr Gly Ser Ser Ser Asn Ile Gly Ala Gly Tyr Asp Val His 
1               5                   10                  


<210> 1228
<211> 42
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L1"

<400> 1228
actgggagca gctccaacat cggggcaggg tatgatgtac ac                          42


<210> 1229
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L2"

<400> 1229
Gly Asn Thr Asn Arg Pro Ala 
1               5           


<210> 1230
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L2"

<400> 1230
ggtaacacca atcggcccgc a                                                 21


<210> 1231
<211> 11
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L3"

<400> 1231
Gln Ser Tyr Asp Ser Ser Leu Ser Gly Ala Ile 
1               5                   10      


<210> 1232
<211> 33
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L3"

<400> 1232
cagtcgtatg acagcagcct gagtggtgcg atc                                    33


<210> 1233
<211> 366
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region"

<400> 1233
caggtgcagc tgcaggagtc cggagctgag gtgaagatgc gtggggcctc agtgaaggtc       60

tcctgcaagg cttctggtta cacctttagt cactatggta tcagttgggt gcgacaggcc      120

cctggacaag ggctcgagtg gatgggattt atcagcgctt acaatcataa cacaaagtat      180

gcacagaccg tccagggcag agtcaccttg agcacagaca catccacgag cacagcctac      240

atggagctga ggagcctgag acctgacgac acggccatgt attactgtgc gagagaaccc      300

ccgagtgacg atgctgcaag gctctttgac tactggggcc agggaaccct ggtcactgtc      360

tcctca                                                                 366


<210> 1234
<211> 122
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region"

<400> 1234
Gln Val Gln Leu Gln Glu Ser Gly Ala Glu Val Lys Met Arg Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Ser His Tyr 
            20                  25                  30          


Gly Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Phe Ile Ser Ala Tyr Asn His Asn Thr Lys Tyr Ala Gln Thr Val 
    50                  55                  60                  


Gln Gly Arg Val Thr Leu Ser Thr Asp Thr Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Arg Ser Leu Arg Pro Asp Asp Thr Ala Met Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Glu Pro Pro Ser Asp Asp Ala Ala Arg Leu Phe Asp Tyr Trp 
            100                 105                 110         


Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120         


<210> 1235
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H1"

<400> 1235
Tyr Thr Phe Ser His Tyr Gly Ile Ser 
1               5                   


<210> 1236
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H1"

<400> 1236
tacaccttta gtcactatgg tatcagt                                           27


<210> 1237
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H2"

<400> 1237
Phe Ile Ser Ala Tyr Asn His Asn Thr Lys Tyr Ala Gln Thr Val Gln 
1               5                   10                  15      


Gly 
    


<210> 1238
<211> 51
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H2"

<400> 1238
tttatcagcg cttacaatca taacacaaag tatgcacaga ccgtccaggg c                51


<210> 1239
<211> 15
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H3"

<400> 1239
Ala Arg Glu Pro Pro Ser Asp Asp Ala Ala Arg Leu Phe Asp Tyr 
1               5                   10                  15  


<210> 1240
<211> 45
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H3"

<400> 1240
gcgagagaac ccccgagtga cgatgctgca aggctctttg actac                       45


<210> 1241
<211> 336
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region"

<400> 1241
gaaacgacac tcacgcagtc tccacgctcc ctgcccgtca cccttggaca gccggcctcc       60

atctcctgca ggtctagtca aagcctcgtg tacagtgaag gaaacaccta cttgagttgg      120

tttcagcaga ggccaggcca atctccaagg cgcctaattt ataaggtttc taaccgggac      180

tctggggtcc cagacagatt cagcggcagt gggtcaggca ctgatttcac actgaaaatc      240

agcagggtgg aggctgagga tgttggggtt tattattgca tgcaaggtac acagtggcct      300

gtgacattcg gccaagggac caaggtggaa atcaaa                                336


<210> 1242
<211> 112
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region"

<400> 1242
Glu Thr Thr Leu Thr Gln Ser Pro Arg Ser Leu Pro Val Thr Leu Gly 
1               5                   10                  15      


Gln Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Val Tyr Ser 
            20                  25                  30          


Glu Gly Asn Thr Tyr Leu Ser Trp Phe Gln Gln Arg Pro Gly Gln Ser 
        35                  40                  45              


Pro Arg Arg Leu Ile Tyr Lys Val Ser Asn Arg Asp Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Met Gln Gly 
                85                  90                  95      


Thr Gln Trp Pro Val Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105                 110         


<210> 1243
<211> 16
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L1"

<400> 1243
Arg Ser Ser Gln Ser Leu Val Tyr Ser Glu Gly Asn Thr Tyr Leu Ser 
1               5                   10                  15      


<210> 1244
<211> 48
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L1"

<400> 1244
aggtctagtc aaagcctcgt gtacagtgaa ggaaacacct acttgagt                    48


<210> 1245
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L2"

<400> 1245
Lys Val Ser Asn Arg Asp Ser 
1               5           


<210> 1246
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L2"

<400> 1246
aaggtttcta accgggactc t                                                 21


<210> 1247
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L3"

<400> 1247
Met Gln Gly Thr Gln Trp Pro Val Thr 
1               5                   


<210> 1248
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L3"

<400> 1248
atgcaaggta cacagtggcc tgtgaca                                           27


<210> 1249
<211> 354
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region"

<400> 1249
caggtccagc tggtacagtc tggggctgag gtgaagaagc ctggggcctc agtgagggtc       60

tcctgcaagg tttacggtca caccctcagt gaattatcca tgcactgggt gcgacagggt      120

cctgaaggag gccttgagtg gatgggagct tttgatcatg aagatggtga aggaatctac      180

ccacagaagt tccagggcag aatcaccatg accgcggaca tatcgacaga cacagcccac      240

atggaactga ggagcctcag atctgaggac acggccgttt attactgtgc aacaccgacc      300

ccggttggag caacggactt ctggggccag ggaaccctgg tcaccgtctc ctca            354


<210> 1250
<211> 118
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region"

<400> 1250
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Arg Val Ser Cys Lys Val Tyr Gly His Thr Leu Ser Glu Leu 
            20                  25                  30          


Ser Met His Trp Val Arg Gln Gly Pro Glu Gly Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Ala Phe Asp His Glu Asp Gly Glu Gly Ile Tyr Pro Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Ile Thr Met Thr Ala Asp Ile Ser Thr Asp Thr Ala His 
65                  70                  75                  80  


Met Glu Leu Arg Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Thr Pro Thr Pro Val Gly Ala Thr Asp Phe Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser 
        115             


<210> 1251
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H1"

<400> 1251
His Thr Leu Ser Glu Leu Ser Met His 
1               5                   


<210> 1252
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H1"

<400> 1252
cacaccctca gtgaattatc catgcac                                           27


<210> 1253
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H2"

<400> 1253
Ala Phe Asp His Glu Asp Gly Glu Gly Ile Tyr Pro Gln Lys Phe Gln 
1               5                   10                  15      


Gly 
    


<210> 1254
<211> 51
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H2"

<400> 1254
gcttttgatc atgaagatgg tgaaggaatc tacccacaga agttccaggg c                51


<210> 1255
<211> 11
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H3"

<400> 1255
Ala Thr Pro Thr Pro Val Gly Ala Thr Asp Phe 
1               5                   10      


<210> 1256
<211> 33
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H3"

<400> 1256
gcaacaccga ccccggttgg agcaacggac ttc                                    33


<210> 1257
<211> 321
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region"

<400> 1257
gacatccggg tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga cagagtcacc       60

atcacttgcc gggcaagtca gagcattagc agctacttaa attggtatca acagaaacca      120

ggaaaagccc ctaagctcct gatctatgct gcatccactt tgcagagggg gggcccatca      180

agattcagtg gcagtggatc tgggacagat ttcactctca gcatcagcag tctgcaacct      240

gaagattttg caacttacta ttgtcaacag acttacatta ttccatacac ttttggccag      300

gggaccaagc tggagatcaa a                                                321


<210> 1258
<211> 107
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region"

<400> 1258
Asp Ile Arg Val Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Thr Leu Gln Arg Gly Gly Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Ser Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Thr Tyr Ile Ile Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210> 1259
<211> 11
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L1"

<400> 1259
Arg Ala Ser Gln Ser Ile Ser Ser Tyr Leu Asn 
1               5                   10      


<210> 1260
<211> 33
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L1"

<400> 1260
cgggcaagtc agagcattag cagctactta aat                                    33


<210> 1261
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L2"

<400> 1261
Ala Ala Ser Thr Leu Gln Arg 
1               5           


<210> 1262
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L2"

<400> 1262
gctgcatcca ctttgcagag g                                                 21


<210> 1263
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L3"

<400> 1263
Gln Gln Thr Tyr Ile Ile Pro Tyr Thr 
1               5                   


<210> 1264
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L3"

<400> 1264
caacagactt acattattcc atacact                                           27


<210> 1265
<211> 369
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region"

<400> 1265
caggtgcagc tgcaggagtc gggcccggga ctggtgaagc cttcggagac cctgtccctc       60

acctgcagtg tctctggtgg ctccatcacc aatgttaatt actactgggg ctggatccgc      120

cagccccccg ggaagggcct ggagtggatt gggagtatct attataatgg aaacacctac      180

tacaacccgt ccctccagag tcgagtcacc atgtccgtgg acacgtccaa gaaccacttc      240

tccctgaggc tgacgtctgt gaccgccgca gacacggctg tatatttttg tgcgagagag      300

gggcctaatt gggaattgtt gaatgctttc gatatctggg gccaagggac cacggtcacc      360

gtctcctca                                                              369


<210> 1266
<211> 123
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region"

<400> 1266
Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Ser Val Ser Gly Gly Ser Ile Thr Asn Val 
            20                  25                  30          


Asn Tyr Tyr Trp Gly Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu 
        35                  40                  45              


Trp Ile Gly Ser Ile Tyr Tyr Asn Gly Asn Thr Tyr Tyr Asn Pro Ser 
    50                  55                  60                  


Leu Gln Ser Arg Val Thr Met Ser Val Asp Thr Ser Lys Asn His Phe 
65                  70                  75                  80  


Ser Leu Arg Leu Thr Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Phe 
                85                  90                  95      


Cys Ala Arg Glu Gly Pro Asn Trp Glu Leu Leu Asn Ala Phe Asp Ile 
            100                 105                 110         


Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120             


<210> 1267
<211> 11
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H1"

<400> 1267
Gly Ser Ile Thr Asn Val Asn Tyr Tyr Trp Gly 
1               5                   10      


<210> 1268
<211> 33
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H1"

<400> 1268
ggctccatca ccaatgttaa ttactactgg ggc                                    33


<210> 1269
<211> 16
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H2"

<400> 1269
Ser Ile Tyr Tyr Asn Gly Asn Thr Tyr Tyr Asn Pro Ser Leu Gln Ser 
1               5                   10                  15      


<210> 1270
<211> 48
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H2"

<400> 1270
agtatctatt ataatggaaa cacctactac aacccgtccc tccagagt                    48


<210> 1271
<211> 15
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H3"

<400> 1271
Ala Arg Glu Gly Pro Asn Trp Glu Leu Leu Asn Ala Phe Asp Ile 
1               5                   10                  15  


<210> 1272
<211> 45
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H3"

<400> 1272
gcgagagagg ggcctaattg ggaattgttg aatgctttcg atatc                       45


<210> 1273
<211> 324
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region"

<400> 1273
gacatccagg tgacccagcc accctcggtg tcagtggccc caggacagac ggccaggatt       60

acctgtgggg gaaacaacat tggaagtaaa aatgtgcact ggtaccagca gaagccaggc      120

cgggcccctg tcttggtcgt ctatgaggat acccaccggc cctcagggat ccctgagcga      180

ttctctggct ccaactctgg gaacacggcc accctgacca tcagtagggt cgaagccggg      240

gatgaggccg actattactg tcaggtgtgg gatactagta gtgatcatgt ggtattcggc      300

ggagggacca agctcaccgt ccta                                             324


<210> 1274
<211> 108
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region"

<400> 1274
Asp Ile Gln Val Thr Gln Pro Pro Ser Val Ser Val Ala Pro Gly Gln 
1               5                   10                  15      


Thr Ala Arg Ile Thr Cys Gly Gly Asn Asn Ile Gly Ser Lys Asn Val 
            20                  25                  30          


His Trp Tyr Gln Gln Lys Pro Gly Arg Ala Pro Val Leu Val Val Tyr 
        35                  40                  45              


Glu Asp Thr His Arg Pro Ser Gly Ile Pro Glu Arg Phe Ser Gly Ser 
    50                  55                  60                  


Asn Ser Gly Asn Thr Ala Thr Leu Thr Ile Ser Arg Val Glu Ala Gly 
65                  70                  75                  80  


Asp Glu Ala Asp Tyr Tyr Cys Gln Val Trp Asp Thr Ser Ser Asp His 
                85                  90                  95      


Val Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105             


<210> 1275
<211> 11
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L1"

<400> 1275
Gly Gly Asn Asn Ile Gly Ser Lys Asn Val His 
1               5                   10      


<210> 1276
<211> 33
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L1"

<400> 1276
gggggaaaca acattggaag taaaaatgtg cac                                    33


<210> 1277
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L2"

<400> 1277
Glu Asp Thr His Arg Pro Ser 
1               5           


<210> 1278
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L2"

<400> 1278
gaggataccc accggccctc a                                                 21


<210> 1279
<211> 11
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L3"

<400> 1279
Gln Val Trp Asp Thr Ser Ser Asp His Val Val 
1               5                   10      


<210> 1280
<211> 33
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L3"

<400> 1280
caggtgtggg atactagtag tgatcatgtg gta                                    33


<210> 1281
<211> 363
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region"

<400> 1281
caggtccagc tggtgcagtc tgggggaggc ctggtcaagc ctgaggggtc cctgagactc       60

tcctgtgcag cctctggatt caccttcagt agctatagca tgaactgggt ccgccaggct      120

ccagggaagg ggctggagtg ggtctcatcc attagtagta gtagtagtta catatactac      180

gcagactcag tgaagggccg attcaccatc tccagagaca acgccaagaa ctcactgtat      240

ctgcaaatga acagcctgag agccgaggac acggctgtgt attactgtgc gagagtctca      300

acagaattgg gctactacta catggacgtc tggggcaaag ggaccacggt cactgtctcc      360

tca                                                                    363


<210> 1282
<211> 121
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region"

<400> 1282
Gln Val Gln Leu Val Gln Ser Gly Gly Gly Leu Val Lys Pro Glu Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ser Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ser Ile Ser Ser Ser Ser Ser Tyr Ile Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Val Ser Thr Glu Leu Gly Tyr Tyr Tyr Met Asp Val Trp Gly 
            100                 105                 110         


Lys Gly Thr Thr Val Thr Val Ser Ser 
        115                 120     


<210> 1283
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H1"

<400> 1283
Phe Thr Phe Ser Ser Tyr Ser Met Asn 
1               5                   


<210> 1284
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H1"

<400> 1284
ttcaccttca gtagctatag catgaac                                           27


<210> 1285
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H2"

<400> 1285
Ser Ile Ser Ser Ser Ser Ser Tyr Ile Tyr Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210> 1286
<211> 51
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H2"

<400> 1286
tccattagta gtagtagtag ttacatatac tacgcagact cagtgaaggg c                51


<210> 1287
<211> 14
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H3"

<400> 1287
Ala Arg Val Ser Thr Glu Leu Gly Tyr Tyr Tyr Met Asp Val 
1               5                   10                  


<210> 1288
<211> 42
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H3"

<400> 1288
gcgagagtct caacagaatt gggctactac tacatggacg tc                          42


<210> 1289
<211> 330
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region"

<400> 1289
cagtctgtcc tgacgcagcc gccctcagtg tctggggccc cagggcagag ggtcaccatc       60

tcctgcactg ggagcagctc caacatcggg gcaggttatg atgtacactg gtaccagcag      120

cttccaggaa cagcccccaa actcctcatc tatggtaaca gcaatcggcc ctcaggggtc      180

cctgaccgat tctctggctc caagtctggc acctcagcct ccctggccat cactgggctc      240

caggctgagg atgaggctga ttattactgc cagtcctatg acagcagcct gagtgtggta      300

ttcggcggag ggaccaagct gaccgtccta                                       330


<210> 1290
<211> 110
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region"

<400> 1290
Gln Ser Val Leu Thr Gln Pro Pro Ser Val Ser Gly Ala Pro Gly Gln 
1               5                   10                  15      


Arg Val Thr Ile Ser Cys Thr Gly Ser Ser Ser Asn Ile Gly Ala Gly 
            20                  25                  30          


Tyr Asp Val His Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu 
        35                  40                  45              


Leu Ile Tyr Gly Asn Ser Asn Arg Pro Ser Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Thr Gly Leu 
65                  70                  75                  80  


Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Gln Ser Tyr Asp Ser Ser 
                85                  90                  95      


Leu Ser Val Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 110 


<210> 1291
<211> 14
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L1"

<400> 1291
Thr Gly Ser Ser Ser Asn Ile Gly Ala Gly Tyr Asp Val His 
1               5                   10                  


<210> 1292
<211> 42
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L1"

<400> 1292
actgggagca gctccaacat cggggcaggt tatgatgtac ac                          42


<210> 1293
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L2"

<400> 1293
Gly Asn Ser Asn Arg Pro Ser 
1               5           


<210> 1294
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L2"

<400> 1294
ggtaacagca atcggccctc a                                                 21


<210> 1295
<211> 10
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L3"

<400> 1295
Gln Ser Tyr Asp Ser Ser Leu Ser Val Val 
1               5                   10  


<210> 1296
<211> 30
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L3"

<400> 1296
cagtcctatg acagcagcct gagtgtggta                                        30


<210> 1297
<211> 360
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region"

<400> 1297
caggtccagc ttgtacagtc tggggctgag gtgaagaagc ctggggcctc agtgaagatt       60

tcctgcaagg cttcgggata ccccttcagt tcctatccta tgcattgggt gcgccaggcc      120

cccggacaaa ggcttgagtg gatgggatgg atcaacgttg acaatgagaa cacaaaatat      180

tcatggaagt tccggggcag agtcaccatt accagggaca catccgcgag cacagtttac      240

atggagctga gcagtctgat atctgaagac acggctgtgt attactgtgg gagagactgg      300

gacggggcga tccgtgtctt ggactactgg ggccagggaa ccctggtcac cgtctcctca      360


<210> 1298
<211> 120
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region"

<400> 1298
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Pro Phe Ser Ser Tyr 
            20                  25                  30          


Pro Met His Trp Val Arg Gln Ala Pro Gly Gln Arg Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Asn Val Asp Asn Glu Asn Thr Lys Tyr Ser Trp Lys Phe 
    50                  55                  60                  


Arg Gly Arg Val Thr Ile Thr Arg Asp Thr Ser Ala Ser Thr Val Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Ile Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Gly Arg Asp Trp Asp Gly Ala Ile Arg Val Leu Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser 
        115                 120 


<210> 1299
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H1"

<400> 1299
Tyr Pro Phe Ser Ser Tyr Pro Met His 
1               5                   


<210> 1300
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H1"

<400> 1300
taccccttca gttcctatcc tatgcat                                           27


<210> 1301
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H2"

<400> 1301
Trp Ile Asn Val Asp Asn Glu Asn Thr Lys Tyr Ser Trp Lys Phe Arg 
1               5                   10                  15      


Gly 
    


<210> 1302
<211> 51
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H2"

<400> 1302
tggatcaacg ttgacaatga gaacacaaaa tattcatgga agttccgggg c                51


<210> 1303
<211> 13
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H3"

<400> 1303
Gly Arg Asp Trp Asp Gly Ala Ile Arg Val Leu Asp Tyr 
1               5                   10              


<210> 1304
<211> 39
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H3"

<400> 1304
gggagagact gggacggggc gatccgtgtc ttggactac                              39


<210> 1305
<211> 339
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region"

<400> 1305
gatattgtga tgactcagac tccagactcc ctggctgtgt ctctgggcga gagggccacc       60

atcacctgca agtccagcca gagtgtttta ttcagctccg acaataagaa ctacttagct      120

tggtaccagc agaaaccggg acagcctcct aaattgctca tttactgggc atctatccgg      180

gaatccgggg tccctgaccg attcggtggc agcgggtctg ggacacattt cactctcacc      240

atcaccagcg tgcaggctgc agatgtggca gtttattact gtcagcaata ttatggtaat      300

ttccccacct tcggccaagg gacacgactg gagattaaa                             339


<210> 1306
<211> 113
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region"

<400> 1306
Asp Ile Val Met Thr Gln Thr Pro Asp Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Glu Arg Ala Thr Ile Thr Cys Lys Ser Ser Gln Ser Val Leu Phe Ser 
            20                  25                  30          


Ser Asp Asn Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Pro Pro Lys Leu Leu Ile Tyr Trp Ala Ser Ile Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Gly Gly Ser Gly Ser Gly Thr His Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Thr Ser Val Gln Ala Ala Asp Val Ala Val Tyr Tyr Cys Gln Gln 
                85                  90                  95      


Tyr Tyr Gly Asn Phe Pro Thr Phe Gly Gln Gly Thr Arg Leu Glu Ile 
            100                 105                 110         


Lys 
    


<210> 1307
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L1"

<400> 1307
Lys Ser Ser Gln Ser Val Leu Phe Ser Ser Asp Asn Lys Asn Tyr Leu 
1               5                   10                  15      


Ala 
    


<210> 1308
<211> 51
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L1"

<400> 1308
aagtccagcc agagtgtttt attcagctcc gacaataaga actacttagc t                51


<210> 1309
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L2"

<400> 1309
Trp Ala Ser Ile Arg Glu Ser 
1               5           


<210> 1310
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L2"

<400> 1310
tgggcatcta tccgggaatc c                                                 21


<210> 1311
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L3"

<400> 1311
Gln Gln Tyr Tyr Gly Asn Phe Pro Thr 
1               5                   


<210> 1312
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L3"

<400> 1312
cagcaatatt atggtaattt ccccacc                                           27


<210> 1313
<211> 372
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region"

<400> 1313
caggtccagc tggtgcagtc tgggggaggc gtggtccagc ctgggaggtc cctgagactt       60

tcctgtgcag cctctggatt caccttcaga aactatggca tgcactgggt ccgccaggct      120

ccaggcaagg ggctggagtg ggtagcggct gcatcgtatg atgggagtag taagtacttt      180

gcagacgccg tgaagggccg attcagcatc tccagagaca ataccaagaa cacgctgtct      240

ctgcaaatga ccagcctgag agctgaggac acggctgtgt attactgtgc aagagacccc      300

ggagtgggaa gttattataa cgtggtgggt atggacgtct ggggccaagg gaccacggtc      360

accgtctcct ca                                                          372


<210> 1314
<211> 124
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region"

<400> 1314
Gln Val Gln Leu Val Gln Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Arg Asn Tyr 
            20                  25                  30          


Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Ala Ala Ser Tyr Asp Gly Ser Ser Lys Tyr Phe Ala Asp Ala Val 
    50                  55                  60                  


Lys Gly Arg Phe Ser Ile Ser Arg Asp Asn Thr Lys Asn Thr Leu Ser 
65                  70                  75                  80  


Leu Gln Met Thr Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Pro Gly Val Gly Ser Tyr Tyr Asn Val Val Gly Met Asp 
            100                 105                 110         


Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120                 


<210> 1315
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H1"

<400> 1315
Phe Thr Phe Arg Asn Tyr Gly Met His 
1               5                   


<210> 1316
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H1"

<400> 1316
ttcaccttca gaaactatgg catgcac                                           27


<210> 1317
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H2"

<400> 1317
Ala Ala Ser Tyr Asp Gly Ser Ser Lys Tyr Phe Ala Asp Ala Val Lys 
1               5                   10                  15      


Gly 
    


<210> 1318
<211> 51
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H2"

<400> 1318
gctgcatcgt atgatgggag tagtaagtac tttgcagacg ccgtgaaggg c                51


<210> 1319
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H3"

<400> 1319
Ala Arg Asp Pro Gly Val Gly Ser Tyr Tyr Asn Val Val Gly Met Asp 
1               5                   10                  15      


Val 
    


<210> 1320
<211> 51
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H3"

<400> 1320
gcaagagacc ccggagtggg aagttattat aacgtggtgg gtatggacgt c                51


<210> 1321
<211> 336
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region"

<400> 1321
gacatccggt tgacccagtc tccactctcc ctgcccgtca cccttggaca gccggcctcc       60

atctcctgca ggtctagtca aagcctcgta tacagtgatg gaaacaccta cttgaattgg      120

tttcagcaga ggccaggcca atctccaagg cgcctaattt atagggtttc tcaccgggac      180

tctggggtcc cagacagatt cagcggcagt gagtcaggca ctgatttcac actgaaaatc      240

agcagggtgg aggctgagga tgttggcgtt tattactgca tgcaaggtac acactggcct      300

cctacgttcg gccaagggac caaggtggag atcaaa                                336


<210> 1322
<211> 112
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region"

<400> 1322
Asp Ile Arg Leu Thr Gln Ser Pro Leu Ser Leu Pro Val Thr Leu Gly 
1               5                   10                  15      


Gln Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Val Tyr Ser 
            20                  25                  30          


Asp Gly Asn Thr Tyr Leu Asn Trp Phe Gln Gln Arg Pro Gly Gln Ser 
        35                  40                  45              


Pro Arg Arg Leu Ile Tyr Arg Val Ser His Arg Asp Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Glu Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Met Gln Gly 
                85                  90                  95      


Thr His Trp Pro Pro Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105                 110         


<210> 1323
<211> 16
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L1"

<400> 1323
Arg Ser Ser Gln Ser Leu Val Tyr Ser Asp Gly Asn Thr Tyr Leu Asn 
1               5                   10                  15      


<210> 1324
<211> 48
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L1"

<400> 1324
aggtctagtc aaagcctcgt atacagtgat ggaaacacct acttgaat                    48


<210> 1325
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L2"

<400> 1325
Arg Val Ser His Arg Asp Ser 
1               5           


<210> 1326
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L2"

<400> 1326
agggtttctc accgggactc t                                                 21


<210> 1327
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L3"

<400> 1327
Met Gln Gly Thr His Trp Pro Pro Thr 
1               5                   


<210> 1328
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L3"

<400> 1328
atgcaaggta cacactggcc tcctacg                                           27


<210> 1329
<211> 354
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region"

<400> 1329
caggtccagc tggtgcagtc tggggctgag gtgaagaagc ctggggcctc agtgaaggtc       60

gcctgcaagg tttccggatc cagcctcact gaattgtcca ttcaatgggt gcgcttgcct      120

cctggcaaac gccttgagtg gctgggagct tttgatgctg aagatggtgc accaatctac      180

tcaccgaaat tccagggcag agtcaccatg accgaggaca gatcgacaga gacagcctac      240

atggaggtga ccagcctgag atctgaggac acggccctct attactgtgc gactcccctt      300

cccgcgggag cccttgacaa gtggggccag ggaaccctgg tcaccgtctc ctca            354


<210> 1330
<211> 118
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region"

<400> 1330
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ala Cys Lys Val Ser Gly Ser Ser Leu Thr Glu Leu 
            20                  25                  30          


Ser Ile Gln Trp Val Arg Leu Pro Pro Gly Lys Arg Leu Glu Trp Leu 
        35                  40                  45              


Gly Ala Phe Asp Ala Glu Asp Gly Ala Pro Ile Tyr Ser Pro Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Met Thr Glu Asp Arg Ser Thr Glu Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Val Thr Ser Leu Arg Ser Glu Asp Thr Ala Leu Tyr Tyr Cys 
                85                  90                  95      


Ala Thr Pro Leu Pro Ala Gly Ala Leu Asp Lys Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser 
        115             


<210> 1331
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H1"

<400> 1331
Ser Ser Leu Thr Glu Leu Ser Ile Gln 
1               5                   


<210> 1332
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H1"

<400> 1332
tccagcctca ctgaattgtc cattcaa                                           27


<210> 1333
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H2"

<400> 1333
Ala Phe Asp Ala Glu Asp Gly Ala Pro Ile Tyr Ser Pro Lys Phe Gln 
1               5                   10                  15      


Gly 
    


<210> 1334
<211> 51
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H2"

<400> 1334
gcttttgatg ctgaagatgg tgcaccaatc tactcaccga aattccaggg c                51


<210> 1335
<211> 11
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H3"

<400> 1335
Ala Thr Pro Leu Pro Ala Gly Ala Leu Asp Lys 
1               5                   10      


<210> 1336
<211> 33
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H3"

<400> 1336
gcgactcccc ttcccgcggg agcccttgac aag                                    33


<210> 1337
<211> 321
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region"

<400> 1337
gacatccaga tgacccagtc tccatcctcc ctgtctgctt ccgtaggaga cagagtcacc       60

atctcttgcc gggcaagtca gactataagc agatatttaa attggtatca ggtcaagcca      120

gggacagccc ctaagctcct aatctacgct gcatccagtt tgcaaactgg ggtcccatca      180

agattcagtg ccagtggatc tggggcagat ttcactctca ccatcagcag tctgcaacct      240

gaagattttg cgacttacca ctgtcaacaa acttacatta ttccgtacac ttttggccag      300

gggaccaaag tggatatcaa a                                                321


<210> 1338
<211> 107
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region"

<400> 1338
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Ser Cys Arg Ala Ser Gln Thr Ile Ser Arg Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Val Lys Pro Gly Thr Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Ser Leu Gln Thr Gly Val Pro Ser Arg Phe Ser Ala 
    50                  55                  60                  


Ser Gly Ser Gly Ala Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr His Cys Gln Gln Thr Tyr Ile Ile Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Asp Ile Lys 
            100                 105         


<210> 1339
<211> 11
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L1"

<400> 1339
Arg Ala Ser Gln Thr Ile Ser Arg Tyr Leu Asn 
1               5                   10      


<210> 1340
<211> 33
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L1"

<400> 1340
cgggcaagtc agactataag cagatattta aat                                    33


<210> 1341
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L2"

<400> 1341
Ala Ala Ser Ser Leu Gln Thr 
1               5           


<210> 1342
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L2"

<400> 1342
gctgcatcca gtttgcaaac t                                                 21


<210> 1343
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L3"

<400> 1343
Gln Gln Thr Tyr Ile Ile Pro Tyr Thr 
1               5                   


<210> 1344
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L3"

<400> 1344
caacaaactt acattattcc gtacact                                           27


<210> 1345
<211> 381
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region"

<400> 1345
gaggtgcagc tggtggagtc gggcccagga ctggtgaagc cttcacagac cctgtccctc       60

acctgcactg tctctgatgt cctcatcagc agtggtgatt actactggag ttggatccgc      120

cagtccccag ggaagggcct ggagtggctt gggtacatct attataccgg gaagaccaaa      180

tataatccgt ccctcgagag tcgaattacc atgtcagtag acacgtccaa gaaccagttc      240

tccctgaggt tgagctctgt tactgccgca gacacggccg tatatttctg taccagagat      300

ctgggatata gcacctcgtc cccctccttt tactatggga tggacgtctg gggccaaggg      360

accacggtca ccgtctcctc a                                                381


<210> 1346
<211> 127
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region"

<400> 1346
Glu Val Gln Leu Val Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Asp Val Leu Ile Ser Ser Gly 
            20                  25                  30          


Asp Tyr Tyr Trp Ser Trp Ile Arg Gln Ser Pro Gly Lys Gly Leu Glu 
        35                  40                  45              


Trp Leu Gly Tyr Ile Tyr Tyr Thr Gly Lys Thr Lys Tyr Asn Pro Ser 
    50                  55                  60                  


Leu Glu Ser Arg Ile Thr Met Ser Val Asp Thr Ser Lys Asn Gln Phe 
65                  70                  75                  80  


Ser Leu Arg Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Phe 
                85                  90                  95      


Cys Thr Arg Asp Leu Gly Tyr Ser Thr Ser Ser Pro Ser Phe Tyr Tyr 
            100                 105                 110         


Gly Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120                 125         


<210> 1347
<211> 11
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H1"

<400> 1347
Val Leu Ile Ser Ser Gly Asp Tyr Tyr Trp Ser 
1               5                   10      


<210> 1348
<211> 33
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H1"

<400> 1348
gtcctcatca gcagtggtga ttactactgg agt                                    33


<210> 1349
<211> 16
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H2"

<400> 1349
Tyr Ile Tyr Tyr Thr Gly Lys Thr Lys Tyr Asn Pro Ser Leu Glu Ser 
1               5                   10                  15      


<210> 1350
<211> 48
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H2"

<400> 1350
tacatctatt ataccgggaa gaccaaatat aatccgtccc tcgagagt                    48


<210> 1351
<211> 19
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H3"

<400> 1351
Thr Arg Asp Leu Gly Tyr Ser Thr Ser Ser Pro Ser Phe Tyr Tyr Gly 
1               5                   10                  15      


Met Asp Val 
            


<210> 1352
<211> 57
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H3"

<400> 1352
accagagatc tgggatatag cacctcgtcc ccctcctttt actatgggat ggacgtc          57


<210> 1353
<211> 321
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region"

<400> 1353
gaaattgtgt tgacacagtc tccagccacc ctgtctttgt ctccagggga aagagccacc       60

ctctcctgca gggccagtca gagtgttggg acctacttag cctggtacca acagaaacct      120

ggccaggctc ccaggctcct catctatgat gcatcttaca gggtcactgg catcccagcc      180

aggttcagtg ccagtgggtc tgcgacagac ttcactctca ccatcagcag cctagagcct      240

gaagattttg cagtttattt ctgtcagcag cgtaccaact ggccgatcac cttcggccag      300

gggacacgac tggagattaa a                                                321


<210> 1354
<211> 107
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region"

<400> 1354
Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Gly Thr Tyr 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 
        35                  40                  45              


Tyr Asp Ala Ser Tyr Arg Val Thr Gly Ile Pro Ala Arg Phe Ser Ala 
    50                  55                  60                  


Ser Gly Ser Ala Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Val Tyr Phe Cys Gln Gln Arg Thr Asn Trp Pro Ile 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Arg Leu Glu Ile Lys 
            100                 105         


<210> 1355
<211> 11
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L1"

<400> 1355
Arg Ala Ser Gln Ser Val Gly Thr Tyr Leu Ala 
1               5                   10      


<210> 1356
<211> 33
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L1"

<400> 1356
agggccagtc agagtgttgg gacctactta gcc                                    33


<210> 1357
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L2"

<400> 1357
Asp Ala Ser Tyr Arg Val Thr 
1               5           


<210> 1358
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L2"

<400> 1358
gatgcatctt acagggtcac t                                                 21


<210> 1359
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L3"

<400> 1359
Gln Gln Arg Thr Asn Trp Pro Ile Thr 
1               5                   


<210> 1360
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L3"

<400> 1360
cagcagcgta ccaactggcc gatcacc                                           27


<210> 1361
<211> 366
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region"

<400> 1361
caggtccagc ttgtgcagtc tggacctgag gtgaagaagc ctggggcctc agtgacggtc       60

tcctgcaagg cttccggtta cacctttagc cattacggta ttagttgggt gcgacaggcc      120

cctggacaag ggcttgagtg gatggggtgg atcagcgcgt accatggtca gacaaactat      180

gcacagaact tccagggcag agtcaccatg accacagaca catcctcgaa cacagcctac      240

atggaggtca ggagcctgag atctgacgac acggccgttt atttctgtgc gagagatgtc      300

ttttcgaaaa cagcagctcg aatctttgac tactggggcc agggaaccct ggtcaccgtc      360

tcctca                                                                 366


<210> 1362
<211> 122
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region"

<400> 1362
Gln Val Gln Leu Val Gln Ser Gly Pro Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Thr Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Ser His Tyr 
            20                  25                  30          


Gly Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Ser Ala Tyr His Gly Gln Thr Asn Tyr Ala Gln Asn Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Met Thr Thr Asp Thr Ser Ser Asn Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Val Arg Ser Leu Arg Ser Asp Asp Thr Ala Val Tyr Phe Cys 
                85                  90                  95      


Ala Arg Asp Val Phe Ser Lys Thr Ala Ala Arg Ile Phe Asp Tyr Trp 
            100                 105                 110         


Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120         


<210> 1363
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H1"

<400> 1363
Tyr Thr Phe Ser His Tyr Gly Ile Ser 
1               5                   


<210> 1364
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H1"

<400> 1364
tacaccttta gccattacgg tattagt                                           27


<210> 1365
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H2"

<400> 1365
Trp Ile Ser Ala Tyr His Gly Gln Thr Asn Tyr Ala Gln Asn Phe Gln 
1               5                   10                  15      


Gly 
    


<210> 1366
<211> 51
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H2"

<400> 1366
tggatcagcg cgtaccatgg tcagacaaac tatgcacaga acttccaggg c                51


<210> 1367
<211> 15
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H3"

<400> 1367
Ala Arg Asp Val Phe Ser Lys Thr Ala Ala Arg Ile Phe Asp Tyr 
1               5                   10                  15  


<210> 1368
<211> 45
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H3"

<400> 1368
gcgagagatg tcttttcgaa aacagcagct cgaatctttg actac                       45


<210> 1369
<211> 336
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region"

<400> 1369
gaaattgtat tgacgcagtc tccactctcc ctgcccgtca cccttggaca gccggcctcc       60

atctcctgca ggtctagtca aagcctcgaa tatagtgacg gaaacaccta cttgagttgg      120

tttcagcaga ggccaggcca atctccaagg cgcctaattt ataaggtttc taaccgggac      180

tctggggtcc cagacagatt cagcggcagt cagtcaggca ctgatttcac actgaaaatc      240

agcagggtgg aggctgagga tgttggggtt tattactgca tgcaagctac agactggccg      300

gtcacgttcg gccaagggac caagctggag atcaaa                                336


<210> 1370
<211> 112
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region"

<400> 1370
Glu Ile Val Leu Thr Gln Ser Pro Leu Ser Leu Pro Val Thr Leu Gly 
1               5                   10                  15      


Gln Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Glu Tyr Ser 
            20                  25                  30          


Asp Gly Asn Thr Tyr Leu Ser Trp Phe Gln Gln Arg Pro Gly Gln Ser 
        35                  40                  45              


Pro Arg Arg Leu Ile Tyr Lys Val Ser Asn Arg Asp Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gln Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Met Gln Ala 
                85                  90                  95      


Thr Asp Trp Pro Val Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


<210> 1371
<211> 16
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L1"

<400> 1371
Arg Ser Ser Gln Ser Leu Glu Tyr Ser Asp Gly Asn Thr Tyr Leu Ser 
1               5                   10                  15      


<210> 1372
<211> 48
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L1"

<400> 1372
aggtctagtc aaagcctcga atatagtgac ggaaacacct acttgagt                    48


<210> 1373
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L2"

<400> 1373
Lys Val Ser Asn Arg Asp Ser 
1               5           


<210> 1374
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L2"

<400> 1374
aaggtttcta accgggactc t                                                 21


<210> 1375
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L3"

<400> 1375
Met Gln Ala Thr Asp Trp Pro Val Thr 
1               5                   


<210> 1376
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L3"

<400> 1376
atgcaagcta cagactggcc ggtcacg                                           27


<210> 1377
<211> 384
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region"

<400> 1377
caggtgcagc tgcaggagtc gggcccaaga ctggtgaagc cttcgcagac cctgtccctc       60

acctgcactg tctctggtgg ctccatcagc agtggtgatt attactggag ttggatccgc      120

cagcccccag ggaagggcct ggagtggatt gggtacatct attacagtgg gagcacccac      180

tacaacccgt ccctcaagag tcgagttagc atgtcagtag acacggccaa gaaccagttc      240

tccctgaagc tgacctctgt gactgccgca gacacggccg tctattactg tgccagagat      300

atcggctacg gtgaccacgg gactgggtct tattactacg gaatagaaga ctggggccaa      360

gggaccacgg tcaccgtctc ctca                                             384


<210> 1378
<211> 128
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region"

<400> 1378
Gln Val Gln Leu Gln Glu Ser Gly Pro Arg Leu Val Lys Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Gly Ser Ile Ser Ser Gly 
            20                  25                  30          


Asp Tyr Tyr Trp Ser Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu 
        35                  40                  45              


Trp Ile Gly Tyr Ile Tyr Tyr Ser Gly Ser Thr His Tyr Asn Pro Ser 
    50                  55                  60                  


Leu Lys Ser Arg Val Ser Met Ser Val Asp Thr Ala Lys Asn Gln Phe 
65                  70                  75                  80  


Ser Leu Lys Leu Thr Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr 
                85                  90                  95      


Cys Ala Arg Asp Ile Gly Tyr Gly Asp His Gly Thr Gly Ser Tyr Tyr 
            100                 105                 110         


Tyr Gly Ile Glu Asp Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120                 125             


<210> 1379
<211> 11
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H1"

<400> 1379
Gly Ser Ile Ser Ser Gly Asp Tyr Tyr Trp Ser 
1               5                   10      


<210> 1380
<211> 33
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H1"

<400> 1380
ggctccatca gcagtggtga ttattactgg agt                                    33


<210> 1381
<211> 16
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H2"

<400> 1381
Tyr Ile Tyr Tyr Ser Gly Ser Thr His Tyr Asn Pro Ser Leu Lys Ser 
1               5                   10                  15      


<210> 1382
<211> 48
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H2"

<400> 1382
tacatctatt acagtgggag cacccactac aacccgtccc tcaagagt                    48


<210> 1383
<211> 20
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H3"

<400> 1383
Ala Arg Asp Ile Gly Tyr Gly Asp His Gly Thr Gly Ser Tyr Tyr Tyr 
1               5                   10                  15      


Gly Ile Glu Asp 
            20  


<210> 1384
<211> 60
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H3"

<400> 1384
gccagagata tcggctacgg tgaccacggg actgggtctt attactacgg aatagaagac       60


<210> 1385
<211> 318
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region"

<400> 1385
gatattgtga tgactcagac tccagccacc ctgtctttgt ctccagggga cagagccacc       60

ctctcctgca gggccagtca gaatattatg agctacttag cctggtacca acacaaacct      120

ggccagcctc ccaggctcct catctatgat gcatcctaca gggccgctgg catcccagcc      180

aggttcagtg gcagtgggtc tgggacagac ttcactctca ccatcagcag cctagagcct      240

gaagattttg cagtttatta ctgtcagcag cgaaccaact ggatcacctt cggccaaggg      300

acacgactgg agattaaa                                                    318


<210> 1386
<211> 106
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region"

<400> 1386
Asp Ile Val Met Thr Gln Thr Pro Ala Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Asp Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Asn Ile Met Ser Tyr 
            20                  25                  30          


Leu Ala Trp Tyr Gln His Lys Pro Gly Gln Pro Pro Arg Leu Leu Ile 
        35                  40                  45              


Tyr Asp Ala Ser Tyr Arg Ala Ala Gly Ile Pro Ala Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Arg Thr Asn Trp Ile Thr 
                85                  90                  95      


Phe Gly Gln Gly Thr Arg Leu Glu Ile Lys 
            100                 105     


<210> 1387
<211> 11
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L1"

<400> 1387
Arg Ala Ser Gln Asn Ile Met Ser Tyr Leu Ala 
1               5                   10      


<210> 1388
<211> 33
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L1"

<400> 1388
agggccagtc agaatattat gagctactta gcc                                    33


<210> 1389
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L2"

<400> 1389
Asp Ala Ser Tyr Arg Ala Ala 
1               5           


<210> 1390
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L2"

<400> 1390
gatgcatcct acagggccgc t                                                 21


<210> 1391
<211> 8
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L3"

<400> 1391
Gln Gln Arg Thr Asn Trp Ile Thr 
1               5               


<210> 1392
<211> 24
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L3"

<400> 1392
cagcagcgaa ccaactggat cacc                                              24


<210> 1393
<211> 369
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region"

<400> 1393
gaggtgcagc tggtggagtc agggggaggc ttggtgcagc ggggggggtc cctgagactc       60

tcgtgtgcgg cctctggatt cacctttagt ggtaatgcca tgagctgggt ccgccaggct      120

ccagggaagg ggctggagtg ggtcgcatct attggtgaaa gtgctactag cgcatactac      180

gcagactccg tgaagggccg gttcaccatc tccagagatg attcgaagaa cactctgtat      240

ctccaaatga acagcctgag acccgaggac acggccgtat atttctgtgc gaaagatcgc      300

gtaggatggt tcggggagtt cgacgctttt gatttctggg gccaagggac aatggtcacc      360

gtctcttca                                                              369


<210> 1394
<211> 123
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region"

<400> 1394
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Arg Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Gly Asn 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Ser Ile Gly Glu Ser Ala Thr Ser Ala Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr Phe Cys 
                85                  90                  95      


Ala Lys Asp Arg Val Gly Trp Phe Gly Glu Phe Asp Ala Phe Asp Phe 
            100                 105                 110         


Trp Gly Gln Gly Thr Met Val Thr Val Ser Ser 
        115                 120             


<210> 1395
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H1"

<400> 1395
Phe Thr Phe Ser Gly Asn Ala Met Ser 
1               5                   


<210> 1396
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H1"

<400> 1396
ttcaccttta gtggtaatgc catgagc                                           27


<210> 1397
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H2"

<400> 1397
Ser Ile Gly Glu Ser Ala Thr Ser Ala Tyr Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210> 1398
<211> 51
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H2"

<400> 1398
tctattggtg aaagtgctac tagcgcatac tacgcagact ccgtgaaggg c                51


<210> 1399
<211> 16
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H3"

<400> 1399
Ala Lys Asp Arg Val Gly Trp Phe Gly Glu Phe Asp Ala Phe Asp Phe 
1               5                   10                  15      


<210> 1400
<211> 48
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H3"

<400> 1400
gcgaaagatc gcgtaggatg gttcggggag ttcgacgctt ttgatttc                    48


<210> 1401
<211> 324
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region"

<400> 1401
tcctatgagc tgacgcagcc accctcagtg tcagtggccc caggaaagac ggccaccatt       60

tcctgtgggg gaaacaacat tggaggtcac aaagtgcact ggtaccagca gaggccaggc      120

caggcccctg tcttggtcat ctattatgat aacgtccggc cctcagggat ccctgagcga      180

ttctctggct ccaactctgg aaacacggcc accctgacca tcagcagggt cgaggccggg      240

gatgaggccg acttttactg tcaggtgtgg gatagtcgtt ctgaacatgt catattcggc      300

ggggggacca aggtcaccgt ccta                                             324


<210> 1402
<211> 108
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region"

<400> 1402
Ser Tyr Glu Leu Thr Gln Pro Pro Ser Val Ser Val Ala Pro Gly Lys 
1               5                   10                  15      


Thr Ala Thr Ile Ser Cys Gly Gly Asn Asn Ile Gly Gly His Lys Val 
            20                  25                  30          


His Trp Tyr Gln Gln Arg Pro Gly Gln Ala Pro Val Leu Val Ile Tyr 
        35                  40                  45              


Tyr Asp Asn Val Arg Pro Ser Gly Ile Pro Glu Arg Phe Ser Gly Ser 
    50                  55                  60                  


Asn Ser Gly Asn Thr Ala Thr Leu Thr Ile Ser Arg Val Glu Ala Gly 
65                  70                  75                  80  


Asp Glu Ala Asp Phe Tyr Cys Gln Val Trp Asp Ser Arg Ser Glu His 
                85                  90                  95      


Val Ile Phe Gly Gly Gly Thr Lys Val Thr Val Leu 
            100                 105             


<210> 1403
<211> 11
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L1"

<400> 1403
Gly Gly Asn Asn Ile Gly Gly His Lys Val His 
1               5                   10      


<210> 1404
<211> 33
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L1"

<400> 1404
gggggaaaca acattggagg tcacaaagtg cac                                    33


<210> 1405
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L2"

<400> 1405
Tyr Asp Asn Val Arg Pro Ser 
1               5           


<210> 1406
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L2"

<400> 1406
tatgataacg tccggccctc a                                                 21


<210> 1407
<211> 11
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L3"

<400> 1407
Gln Val Trp Asp Ser Arg Ser Glu His Val Ile 
1               5                   10      


<210> 1408
<211> 33
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L3"

<400> 1408
caggtgtggg atagtcgttc tgaacatgtc ata                                    33


<210> 1409
<211> 363
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region"

<400> 1409
caggtccagc ttgtacagtc tggagctgag gtgaagaagc ctggggcctc agtgaaggtc       60

tcgtgcaaga cttctggtta caccttttcc aactacggta tcagctggct gcgacaggcc      120

cctggacaag ggcttgagtg gatggcatgg atcagccctt ataatgggaa cacaaagtct      180

gcacagaggt ttcagggcag agtcatcatg accacagaca catccacgag gacagcccac      240

atggaggtga agagcctgag aactgacgac acggccacat attactgtgc gagagatcca      300

gcagtcgatg caataccgat gcttgactac tggggccagg gaaccctggt caccgtctcc      360

tca                                                                    363


<210> 1410
<211> 121
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region"

<400> 1410
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Thr Ser Gly Tyr Thr Phe Ser Asn Tyr 
            20                  25                  30          


Gly Ile Ser Trp Leu Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Ala Trp Ile Ser Pro Tyr Asn Gly Asn Thr Lys Ser Ala Gln Arg Phe 
    50                  55                  60                  


Gln Gly Arg Val Ile Met Thr Thr Asp Thr Ser Thr Arg Thr Ala His 
65                  70                  75                  80  


Met Glu Val Lys Ser Leu Arg Thr Asp Asp Thr Ala Thr Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Pro Ala Val Asp Ala Ile Pro Met Leu Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120     


<210> 1411
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H1"

<400> 1411
Tyr Thr Phe Ser Asn Tyr Gly Ile Ser 
1               5                   


<210> 1412
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H1"

<400> 1412
tacacctttt ccaactacgg tatcagc                                           27


<210> 1413
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H2"

<400> 1413
Trp Ile Ser Pro Tyr Asn Gly Asn Thr Lys Ser Ala Gln Arg Phe Gln 
1               5                   10                  15      


Gly 
    


<210> 1414
<211> 51
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H2"

<400> 1414
tggatcagcc cttataatgg gaacacaaag tctgcacaga ggtttcaggg c                51


<210> 1415
<211> 14
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H3"

<400> 1415
Ala Arg Asp Pro Ala Val Asp Ala Ile Pro Met Leu Asp Tyr 
1               5                   10                  


<210> 1416
<211> 42
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H3"

<400> 1416
gcgagagatc cagcagtcga tgcaataccg atgcttgact ac                          42


<210> 1417
<211> 336
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region"

<400> 1417
gacatccaga tgacccagtc tccactctcc ctgcccgtca cccttggaca gccggcctcc       60

atctcctgca ggtctagtca aagcctcgtg tacactgatg gaaacaccta cttgagctgg      120

tttcagcaga ggccaggcca atctccaagg cgcctaattt atagggtttc tcaccgggac      180

tctggggtcc cagacagatt caccggcagt gggtcaggca ctgatttcac actgataatc      240

cgcagggtgg aggctgagga tgttggggtt tattactgca tgcaaggtac acactggcct      300

ctcactttcg gcggagggac caagctggag atcaaa                                336


<210> 1418
<211> 112
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region"

<400> 1418
Asp Ile Gln Met Thr Gln Ser Pro Leu Ser Leu Pro Val Thr Leu Gly 
1               5                   10                  15      


Gln Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Val Tyr Thr 
            20                  25                  30          


Asp Gly Asn Thr Tyr Leu Ser Trp Phe Gln Gln Arg Pro Gly Gln Ser 
        35                  40                  45              


Pro Arg Arg Leu Ile Tyr Arg Val Ser His Arg Asp Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Ile Ile 
65                  70                  75                  80  


Arg Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Met Gln Gly 
                85                  90                  95      


Thr His Trp Pro Leu Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


<210> 1419
<211> 16
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L1"

<400> 1419
Arg Ser Ser Gln Ser Leu Val Tyr Thr Asp Gly Asn Thr Tyr Leu Ser 
1               5                   10                  15      


<210> 1420
<211> 48
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L1"

<400> 1420
aggtctagtc aaagcctcgt gtacactgat ggaaacacct acttgagc                    48


<210> 1421
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L2"

<400> 1421
Arg Val Ser His Arg Asp Ser 
1               5           


<210> 1422
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L2"

<400> 1422
agggtttctc accgggactc t                                                 21


<210> 1423
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L3"

<400> 1423
Met Gln Gly Thr His Trp Pro Leu Thr 
1               5                   


<210> 1424
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L3"

<400> 1424
atgcaaggta cacactggcc tctcact                                           27


<210> 1425
<211> 378
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region"

<400> 1425
caggtccagc tggtacagtc tggtcctgcg ctggtgaaac ccacacagac cctcacactg       60

acctgcacct tcggtggatt ctcactcagc agacatggaa tgcgtgtgac ctggatccgt      120

caggcccccg ggaaggccct ggagtggctt ggtcacattg attgggatga tgataaattc      180

tacaggacat ctctgaagac caggctcacc atctccaagg acccctctaa caatgaggtg      240

gtcctgaaaa tgaccaacat ggaccacgtg gacacagcca cgtattactg tgcactgatg      300

aggccctttt ggagtcgtga cgactactac tattccatcg ccgtctgggg caaagggacc      360

acggtcaccg tctcctca                                                    378


<210> 1426
<211> 126
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region"

<400> 1426
Gln Val Gln Leu Val Gln Ser Gly Pro Ala Leu Val Lys Pro Thr Gln 
1               5                   10                  15      


Thr Leu Thr Leu Thr Cys Thr Phe Gly Gly Phe Ser Leu Ser Arg His 
            20                  25                  30          


Gly Met Arg Val Thr Trp Ile Arg Gln Ala Pro Gly Lys Ala Leu Glu 
        35                  40                  45              


Trp Leu Gly His Ile Asp Trp Asp Asp Asp Lys Phe Tyr Arg Thr Ser 
    50                  55                  60                  


Leu Lys Thr Arg Leu Thr Ile Ser Lys Asp Pro Ser Asn Asn Glu Val 
65                  70                  75                  80  


Val Leu Lys Met Thr Asn Met Asp His Val Asp Thr Ala Thr Tyr Tyr 
                85                  90                  95      


Cys Ala Leu Met Arg Pro Phe Trp Ser Arg Asp Asp Tyr Tyr Tyr Ser 
            100                 105                 110         


Ile Ala Val Trp Gly Lys Gly Thr Thr Val Thr Val Ser Ser 
        115                 120                 125     


<210> 1427
<211> 11
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H1"

<400> 1427
Phe Ser Leu Ser Arg His Gly Met Arg Val Thr 
1               5                   10      


<210> 1428
<211> 33
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H1"

<400> 1428
ttctcactca gcagacatgg aatgcgtgtg acc                                    33


<210> 1429
<211> 16
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H2"

<400> 1429
His Ile Asp Trp Asp Asp Asp Lys Phe Tyr Arg Thr Ser Leu Lys Thr 
1               5                   10                  15      


<210> 1430
<211> 48
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H2"

<400> 1430
cacattgatt gggatgatga taaattctac aggacatctc tgaagacc                    48


<210> 1431
<211> 18
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H3"

<400> 1431
Ala Leu Met Arg Pro Phe Trp Ser Arg Asp Asp Tyr Tyr Tyr Ser Ile 
1               5                   10                  15      


Ala Val 
        


<210> 1432
<211> 54
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H3"

<400> 1432
gcactgatga ggcccttttg gagtcgtgac gactactact attccatcgc cgtc             54


<210> 1433
<211> 345
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region"

<400> 1433
gatattgtgc tgacccagtc tccaggcacc ctgtctttgt ctccagggga cagagccacc       60

ctctcctgca gggccagtca gagtgtcggc agcggctacg taacctggta ccagcagaaa      120

cctggccagg ctcccaggct cctcatttat ggtgcatcaa acagggccga aggcatccca      180

gacaggttca gtggcagtgg gtctgggaca gacttcactc tcaccatcag cggactggag      240

tctgaagatt ttgtaattta ttactgtcag ctatatcata ggtcacctgg ctctgcgagt      300

caaaccgttt ggacgttcgg ccaagggacc aaggtggaaa tcaaa                      345


<210> 1434
<211> 115
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region"

<400> 1434
Asp Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Asp Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Gly Ser Gly 
            20                  25                  30          


Tyr Val Thr Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu 
        35                  40                  45              


Ile Tyr Gly Ala Ser Asn Arg Ala Glu Gly Ile Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Gly Leu Glu 
65                  70                  75                  80  


Ser Glu Asp Phe Val Ile Tyr Tyr Cys Gln Leu Tyr His Arg Ser Pro 
                85                  90                  95      


Gly Ser Ala Ser Gln Thr Val Trp Thr Phe Gly Gln Gly Thr Lys Val 
            100                 105                 110         


Glu Ile Lys 
        115 


<210> 1435
<211> 12
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L1"

<400> 1435
Arg Ala Ser Gln Ser Val Gly Ser Gly Tyr Val Thr 
1               5                   10          


<210> 1436
<211> 36
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L1"

<400> 1436
agggccagtc agagtgtcgg cagcggctac gtaacc                                 36


<210> 1437
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L2"

<400> 1437
Gly Ala Ser Asn Arg Ala Glu 
1               5           


<210> 1438
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L2"

<400> 1438
ggtgcatcaa acagggccga a                                                 21


<210> 1439
<211> 16
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L3"

<400> 1439
Gln Leu Tyr His Arg Ser Pro Gly Ser Ala Ser Gln Thr Val Trp Thr 
1               5                   10                  15      


<210> 1440
<211> 48
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L3"

<400> 1440
cagctatatc ataggtcacc tggctctgcg agtcaaaccg tttggacg                    48


<210> 1441
<211> 363
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region"

<400> 1441
caggtccagc ttgtacagtc tggacctgag gtgaagaagc ctggggcctc agtgagggtc       60

tcctgcgagg cttctggtta cccctttagc aattacggca tcacctgggt gcgccaggcc      120

cctggacaag ggcttgagtg gatgggatgg atcagcgctt acaacggaaa cagagactat      180

ctgcagaagt ttcagggcag actcaccatg accatagaca catccacgag aacagcccac      240

atggaattga ggcgcctgac atctgacgac acggccgtat attggtgtgc gagagacaca      300

cccgccactg ctgcccctct gcttgactac tggggccagg gaaccctggt caccgtctcc      360

tca                                                                    363


<210> 1442
<211> 121
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region"

<400> 1442
Gln Val Gln Leu Val Gln Ser Gly Pro Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Arg Val Ser Cys Glu Ala Ser Gly Tyr Pro Phe Ser Asn Tyr 
            20                  25                  30          


Gly Ile Thr Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Ser Ala Tyr Asn Gly Asn Arg Asp Tyr Leu Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Leu Thr Met Thr Ile Asp Thr Ser Thr Arg Thr Ala His 
65                  70                  75                  80  


Met Glu Leu Arg Arg Leu Thr Ser Asp Asp Thr Ala Val Tyr Trp Cys 
                85                  90                  95      


Ala Arg Asp Thr Pro Ala Thr Ala Ala Pro Leu Leu Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120     


<210> 1443
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H1"

<400> 1443
Tyr Pro Phe Ser Asn Tyr Gly Ile Thr 
1               5                   


<210> 1444
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H1"

<400> 1444
taccccttta gcaattacgg catcacc                                           27


<210> 1445
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H2"

<400> 1445
Trp Ile Ser Ala Tyr Asn Gly Asn Arg Asp Tyr Leu Gln Lys Phe Gln 
1               5                   10                  15      


Gly 
    


<210> 1446
<211> 51
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H2"

<400> 1446
tggatcagcg cttacaacgg aaacagagac tatctgcaga agtttcaggg c                51


<210> 1447
<211> 14
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H3"

<400> 1447
Ala Arg Asp Thr Pro Ala Thr Ala Ala Pro Leu Leu Asp Tyr 
1               5                   10                  


<210> 1448
<211> 42
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H3"

<400> 1448
gcgagagaca cacccgccac tgctgcccct ctgcttgact ac                          42


<210> 1449
<211> 336
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region"

<400> 1449
gatattgtga tgactcagtc tccactctcc ctggccgtca cccttggaca gccggcctcc       60

atctcctgca ggtctagtca aagcctcgaa ttcactgatg gaaacaccta cttgaattgg      120

tttcagcaga ggccaggcca atctccaagg cgcctaattt ataaggtttc taaccgggac      180

tctggggtcc cagacagatt cagcggcagt gggtcaggca ctggtttcac actgaaaatc      240

agcagggtgg aggctgagga tgttggggtt tattactgca tgcaaggtat tttccggccg      300

gggacgttcg gccaagggac caaggtggaa atcaaa                                336


<210> 1450
<211> 112
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region"

<400> 1450
Asp Ile Val Met Thr Gln Ser Pro Leu Ser Leu Ala Val Thr Leu Gly 
1               5                   10                  15      


Gln Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Glu Phe Thr 
            20                  25                  30          


Asp Gly Asn Thr Tyr Leu Asn Trp Phe Gln Gln Arg Pro Gly Gln Ser 
        35                  40                  45              


Pro Arg Arg Leu Ile Tyr Lys Val Ser Asn Arg Asp Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Gly Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Met Gln Gly 
                85                  90                  95      


Ile Phe Arg Pro Gly Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105                 110         


<210> 1451
<211> 16
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L1"

<400> 1451
Arg Ser Ser Gln Ser Leu Glu Phe Thr Asp Gly Asn Thr Tyr Leu Asn 
1               5                   10                  15      


<210> 1452
<211> 48
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L1"

<400> 1452
aggtctagtc aaagcctcga attcactgat ggaaacacct acttgaat                    48


<210> 1453
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L2"

<400> 1453
Lys Val Ser Asn Arg Asp Ser 
1               5           


<210> 1454
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L2"

<400> 1454
aaggtttcta accgggactc t                                                 21


<210> 1455
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L3"

<400> 1455
Met Gln Gly Ile Phe Arg Pro Gly Thr 
1               5                   


<210> 1456
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L3"

<400> 1456
atgcaaggta ttttccggcc ggggacg                                           27


<210> 1457
<211> 363
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region"

<400> 1457
caggtccagc tggtgcagtc tggagctgag gtgaagaagc ctggggcctc agtgaaggtc       60

tcctgcaagg cttctggtta cacctttgtc cactatggta tcagttgggt gcgacaggcc      120

cctggacaag ggcttgagtg gatgggatgg atcagcgcat acaatggtaa tacaaactct      180

gcactgaagt tccaggacag agtcaccatg accacagacc catccacgag cacagcctac      240

atggagctga ggagcctgag atctgacgac acggccattt attactgtgc gagagactca      300

ggttgttgta gtggttccac ctcagacgtc tggggcaaag ggaccacggt caccgtctcc      360

tca                                                                    363


<210> 1458
<211> 121
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region"

<400> 1458
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Val His Tyr 
            20                  25                  30          


Gly Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Ser Ala Tyr Asn Gly Asn Thr Asn Ser Ala Leu Lys Phe 
    50                  55                  60                  


Gln Asp Arg Val Thr Met Thr Thr Asp Pro Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Arg Ser Leu Arg Ser Asp Asp Thr Ala Ile Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Ser Gly Cys Cys Ser Gly Ser Thr Ser Asp Val Trp Gly 
            100                 105                 110         


Lys Gly Thr Thr Val Thr Val Ser Ser 
        115                 120     


<210> 1459
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H1"

<400> 1459
Tyr Thr Phe Val His Tyr Gly Ile Ser 
1               5                   


<210> 1460
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H1"

<400> 1460
tacacctttg tccactatgg tatcagt                                           27


<210> 1461
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H2"

<400> 1461
Trp Ile Ser Ala Tyr Asn Gly Asn Thr Asn Ser Ala Leu Lys Phe Gln 
1               5                   10                  15      


Asp 
    


<210> 1462
<211> 51
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H2"

<400> 1462
tggatcagcg catacaatgg taatacaaac tctgcactga agttccagga c                51


<210> 1463
<211> 14
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H3"

<400> 1463
Ala Arg Asp Ser Gly Cys Cys Ser Gly Ser Thr Ser Asp Val 
1               5                   10                  


<210> 1464
<211> 42
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H3"

<400> 1464
gcgagagact caggttgttg tagtggttcc acctcagacg tc                          42


<210> 1465
<211> 342
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region"

<400> 1465
gatattgtga tgactcagtc tccactctct tcacctgtca cccttggaca gccggcctcc       60

atctcctgca ggtctagtca aagcctcgtg cacagtgatg gaaacaccta cttgagttgg      120

cttcaccaga ggccaggcca gcctccaaga ctcctaattt ataagatttc ccaccggttc      180

tctggggtcc cagacagatt cactggcagt ggggcaggga cagatttcac actgaaaatc      240

agcagggtgg aggctgagga tgtcggggtt tattactgca tgcaagctac agaatttcct      300

ccgatgtaca cttttggcca ggggaccaag gtggagatca aa                         342


<210> 1466
<211> 114
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region"

<400> 1466
Asp Ile Val Met Thr Gln Ser Pro Leu Ser Ser Pro Val Thr Leu Gly 
1               5                   10                  15      


Gln Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Val His Ser 
            20                  25                  30          


Asp Gly Asn Thr Tyr Leu Ser Trp Leu His Gln Arg Pro Gly Gln Pro 
        35                  40                  45              


Pro Arg Leu Leu Ile Tyr Lys Ile Ser His Arg Phe Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Thr Gly Ser Gly Ala Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Met Gln Ala 
                85                  90                  95      


Thr Glu Phe Pro Pro Met Tyr Thr Phe Gly Gln Gly Thr Lys Val Glu 
            100                 105                 110         


Ile Lys 
        


<210> 1467
<211> 16
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L1"

<400> 1467
Arg Ser Ser Gln Ser Leu Val His Ser Asp Gly Asn Thr Tyr Leu Ser 
1               5                   10                  15      


<210> 1468
<211> 48
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L1"

<400> 1468
aggtctagtc aaagcctcgt gcacagtgat ggaaacacct acttgagt                    48


<210> 1469
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L2"

<400> 1469
Lys Ile Ser His Arg Phe Ser 
1               5           


<210> 1470
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L2"

<400> 1470
aagatttccc accggttctc t                                                 21


<210> 1471
<211> 11
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L3"

<400> 1471
Met Gln Ala Thr Glu Phe Pro Pro Met Tyr Thr 
1               5                   10      


<210> 1472
<211> 33
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L3"

<400> 1472
atgcaagcta cagaatttcc tccgatgtac act                                    33


<210> 1473
<211> 372
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region"

<400> 1473
gaggtgcagc tggtggagac gggcccagga ctggtgaagc cttcggagac cctgtccctc       60

acctgcactg tctctggtga ctccatcagt ggttactact ggagctggat ccggcagtcc      120

ccagggaagg gactggagtg gattggctat atctattaca gggggagcac cgactacaac      180

ccctccctca agagtcgagt caccatatca gtagacacgt ccaagaacca gttctccctg      240

aaactgagct ctgtgaccgc tgcggacacg gccgtgtatt actgtgcgag agataataaa      300

caccatgatt cgggaaatta ttacgcatac tttgaccatt ggggccaggg aaccctggtc      360

accgtctcct ca                                                          372


<210> 1474
<211> 124
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region"

<400> 1474
Glu Val Gln Leu Val Glu Thr Gly Pro Gly Leu Val Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Asp Ser Ile Ser Gly Tyr 
            20                  25                  30          


Tyr Trp Ser Trp Ile Arg Gln Ser Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Tyr Ile Tyr Tyr Arg Gly Ser Thr Asp Tyr Asn Pro Ser Leu Lys 
    50                  55                  60                  


Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe Ser Leu 
65                  70                  75                  80  


Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Asp Asn Lys His His Asp Ser Gly Asn Tyr Tyr Ala Tyr Phe Asp 
            100                 105                 110         


His Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 


<210> 1475
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H1"

<400> 1475
Asp Ser Ile Ser Gly Tyr Tyr Trp Ser 
1               5                   


<210> 1476
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H1"

<400> 1476
gactccatca gtggttacta ctggagc                                           27


<210> 1477
<211> 16
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H2"

<400> 1477
Tyr Ile Tyr Tyr Arg Gly Ser Thr Asp Tyr Asn Pro Ser Leu Lys Ser 
1               5                   10                  15      


<210> 1478
<211> 48
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H2"

<400> 1478
tatatctatt acagggggag caccgactac aacccctccc tcaagagt                    48


<210> 1479
<211> 18
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H3"

<400> 1479
Ala Arg Asp Asn Lys His His Asp Ser Gly Asn Tyr Tyr Ala Tyr Phe 
1               5                   10                  15      


Asp His 
        


<210> 1480
<211> 54
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H3"

<400> 1480
gcgagagata ataaacacca tgattcggga aattattacg catactttga ccat             54


<210> 1481
<211> 321
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region"

<400> 1481
gatattgtga tgactcagtc tccatcctcc ctgtctgcat ctgtaggaga cagagtcacc       60

atcacttgcc gggcaagtca gaacattaac acctttttaa attggtatca gcacaaacca      120

gggaaagccc ctaaactcct gatctatggt gcatcccgtt tgcagagtgg ggtcccatca      180

aggttcactg gcagtggatc tgggacagat ttcactctca ccatcagcag tctgcaacct      240

gaagattttg caacttactc ctgtcaacag agttacacta cccggctcac tttcggcgga      300

gggaccaagg tggaaatcaa a                                                321


<210> 1482
<211> 107
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region"

<400> 1482
Asp Ile Val Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asn Ile Asn Thr Phe 
            20                  25                  30          


Leu Asn Trp Tyr Gln His Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Gly Ala Ser Arg Leu Gln Ser Gly Val Pro Ser Arg Phe Thr Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Ser Cys Gln Gln Ser Tyr Thr Thr Arg Leu 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210> 1483
<211> 11
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L1"

<400> 1483
Arg Ala Ser Gln Asn Ile Asn Thr Phe Leu Asn 
1               5                   10      


<210> 1484
<211> 33
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L1"

<400> 1484
cgggcaagtc agaacattaa caccttttta aat                                    33


<210> 1485
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L2"

<400> 1485
Gly Ala Ser Arg Leu Gln Ser 
1               5           


<210> 1486
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L2"

<400> 1486
ggtgcatccc gtttgcagag t                                                 21


<210> 1487
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L3"

<400> 1487
Gln Gln Ser Tyr Thr Thr Arg Leu Thr 
1               5                   


<210> 1488
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L3"

<400> 1488
caacagagtt acactacccg gctcact                                           27


<210> 1489
<211> 375
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region"

<400> 1489
caggtccagc tggtgcagtc tgggactgag gtgaagaagc ctggggcctc agtgaagatt       60

tcctgcaaga cttctggata caccttcact aataatgtaa ttcaatgggt gcgccaggcc      120

cccggacaaa ggcttgagtg gatgggatgg atcagcgctg gcaatggtta cacaaaatat      180

tcagacaagt tccaggacag agtcaccatt accagggaca catccgcgag cacagcctac      240

atggaggtga gcagcctgac atctgaagac acggctatgt attactgtgc gagacaagtc      300

tcgactagtg gctggcacgc aacgtcacac cggttcgccc cctggggcca gggaaccctg      360

gtcaccgtct cctca                                                       375


<210> 1490
<211> 125
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region"

<400> 1490
Gln Val Gln Leu Val Gln Ser Gly Thr Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Ile Ser Cys Lys Thr Ser Gly Tyr Thr Phe Thr Asn Asn 
            20                  25                  30          


Val Ile Gln Trp Val Arg Gln Ala Pro Gly Gln Arg Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Ser Ala Gly Asn Gly Tyr Thr Lys Tyr Ser Asp Lys Phe 
    50                  55                  60                  


Gln Asp Arg Val Thr Ile Thr Arg Asp Thr Ser Ala Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Val Ser Ser Leu Thr Ser Glu Asp Thr Ala Met Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gln Val Ser Thr Ser Gly Trp His Ala Thr Ser His Arg Phe 
            100                 105                 110         


Ala Pro Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125 


<210> 1491
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H1"

<400> 1491
Tyr Thr Phe Thr Asn Asn Val Ile Gln 
1               5                   


<210> 1492
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H1"

<400> 1492
tacaccttca ctaataatgt aattcaa                                           27


<210> 1493
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H2"

<400> 1493
Trp Ile Ser Ala Gly Asn Gly Tyr Thr Lys Tyr Ser Asp Lys Phe Gln 
1               5                   10                  15      


Asp 
    


<210> 1494
<211> 51
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H2"

<400> 1494
tggatcagcg ctggcaatgg ttacacaaaa tattcagaca agttccagga c                51


<210> 1495
<211> 18
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H3"

<400> 1495
Ala Arg Gln Val Ser Thr Ser Gly Trp His Ala Thr Ser His Arg Phe 
1               5                   10                  15      


Ala Pro 
        


<210> 1496
<211> 54
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H3"

<400> 1496
gcgagacaag tctcgactag tggctggcac gcaacgtcac accggttcgc cccc             54


<210> 1497
<211> 321
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region"

<400> 1497
gacatccaga tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga cagagtcacc       60

atcacttgcc aggcgagtca gggcattagt agatatttaa attggtatca gcagaaacca      120

gggaaagccc ctaacctcct gatctacgat gcatccaatt tggaaacagg ggtcccatca      180

aggttcagtg gaagtggatc tgggacacat tttactttaa ccatcagcag cctgcagcct      240

gaagatattg caacatatta ctgtcaacag tatgataatc tcccgctcac tttcggcgga      300

gggaccaagg tggaaatcaa a                                                321


<210> 1498
<211> 107
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region"

<400> 1498
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Gln Ala Ser Gln Gly Ile Ser Arg Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Asn Leu Leu Ile 
        35                  40                  45              


Tyr Asp Ala Ser Asn Leu Glu Thr Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr His Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Ile Ala Thr Tyr Tyr Cys Gln Gln Tyr Asp Asn Leu Pro Leu 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210> 1499
<211> 11
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L1"

<400> 1499
Gln Ala Ser Gln Gly Ile Ser Arg Tyr Leu Asn 
1               5                   10      


<210> 1500
<211> 33
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L1"

<400> 1500
caggcgagtc agggcattag tagatattta aat                                    33


<210> 1501
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L2"

<400> 1501
Asp Ala Ser Asn Leu Glu Thr 
1               5           


<210> 1502
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L2"

<400> 1502
gatgcatcca atttggaaac a                                                 21


<210> 1503
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L3"

<400> 1503
Gln Gln Tyr Asp Asn Leu Pro Leu Thr 
1               5                   


<210> 1504
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L3"

<400> 1504
caacagtatg ataatctccc gctcact                                           27


<210> 1505
<211> 363
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region"

<400> 1505
gaggtgcagc tggtggagtc tgggggaggc gtggtccagc ctgggaggtc cctgagactc       60

tcctgtgaag cctctggatt caccttcagt agttttagca tgcactgggt ccgccaggct      120

ccgggcaagg ggctggagtg ggtggcagtg attttatatg atgggagtaa tcaatactat      180

gcagactccg tgaagggccg attcaccatc tccagagaca attccaagaa cacgctttat      240

ctgcaaatga acaccctgag agctgaggac acggctatgt attactgtgc gaaatcatca      300

tcgtcccatg ttaactctcg acaagacaaa tggggccagg gcaccctggt caccgtctcc      360

tca                                                                    363


<210> 1506
<211> 121
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region"

<400> 1506
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Glu Ala Ser Gly Phe Thr Phe Ser Ser Phe 
            20                  25                  30          


Ser Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Val Ile Leu Tyr Asp Gly Ser Asn Gln Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Thr Leu Arg Ala Glu Asp Thr Ala Met Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Ser Ser Ser Ser His Val Asn Ser Arg Gln Asp Lys Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120     


<210> 1507
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H1"

<400> 1507
Phe Thr Phe Ser Ser Phe Ser Met His 
1               5                   


<210> 1508
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H1"

<400> 1508
ttcaccttca gtagttttag catgcac                                           27


<210> 1509
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H2"

<400> 1509
Val Ile Leu Tyr Asp Gly Ser Asn Gln Tyr Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210> 1510
<211> 51
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H2"

<400> 1510
gtgattttat atgatgggag taatcaatac tatgcagact ccgtgaaggg c                51


<210> 1511
<211> 14
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H3"

<400> 1511
Ala Lys Ser Ser Ser Ser His Val Asn Ser Arg Gln Asp Lys 
1               5                   10                  


<210> 1512
<211> 42
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H3"

<400> 1512
gcgaaatcat catcgtccca tgttaactct cgacaagaca aa                          42


<210> 1513
<211> 318
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region"

<400> 1513
gaaattgtat tgacacagtc tccttccacc ctgtctgcat ctgtaggaga cagagtcacc       60

atcacttgcc gggccagtca gagtattagt aggtggttgg cctggtatca gcagaaacca      120

ggggaagccc ctaaactcct gatccacacg gcgtctacat tagaaagtgg ggtcccatca      180

aggttcagcg gcagtggctc tgggacagaa ttcactctca ccatcaacag cctgcagcct      240

gatgatcttg caacttatta ctgccaacag tattataatt ggtggacgtt cggccaaggg      300

accaaggtgg agatcaaa                                                    318


<210> 1514
<211> 106
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region"

<400> 1514
Glu Ile Val Leu Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Arg Trp 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Glu Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


His Thr Ala Ser Thr Leu Glu Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Asn Ser Leu Gln Pro 
65                  70                  75                  80  


Asp Asp Leu Ala Thr Tyr Tyr Cys Gln Gln Tyr Tyr Asn Trp Trp Thr 
                85                  90                  95      


Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105     


<210> 1515
<211> 11
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L1"

<400> 1515
Arg Ala Ser Gln Ser Ile Ser Arg Trp Leu Ala 
1               5                   10      


<210> 1516
<211> 33
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L1"

<400> 1516
cgggccagtc agagtattag taggtggttg gcc                                    33


<210> 1517
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L2"

<400> 1517
Thr Ala Ser Thr Leu Glu Ser 
1               5           


<210> 1518
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L2"

<400> 1518
acggcgtcta cattagaaag t                                                 21


<210> 1519
<211> 8
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L3"

<400> 1519
Gln Gln Tyr Tyr Asn Trp Trp Thr 
1               5               


<210> 1520
<211> 24
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L3"

<400> 1520
caacagtatt ataattggtg gacg                                              24


<210> 1521
<211> 366
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region"

<400> 1521
gaggtgcagc tgttggagtc cggagctgag gtgaagaagc ctggggcctc agtgaagatc       60

tcctgcaagg cctctggtta catctttacc agttatggtg tcagttgggt gcgacaggcc      120

cctggacaag ggcttaagtg gatgggatgg atcagcggtt acaatggtaa cacatactat      180

gaccagaaat tccagggcag agtcaccatg accacagaca catccacgaa cacagcctac      240

atggagttga ggagcctgac atctgacgac acggccgtat attactgtgc gagagattcc      300

ttttcagaga ctgggactgg atttcctgac ttctggggcc agggcaccct ggtcaccgtc      360

tcttca                                                                 366


<210> 1522
<211> 122
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region"

<400> 1522
Glu Val Gln Leu Leu Glu Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Ile Phe Thr Ser Tyr 
            20                  25                  30          


Gly Val Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Lys Trp Met 
        35                  40                  45              


Gly Trp Ile Ser Gly Tyr Asn Gly Asn Thr Tyr Tyr Asp Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Met Thr Thr Asp Thr Ser Thr Asn Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Arg Ser Leu Thr Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Ser Phe Ser Glu Thr Gly Thr Gly Phe Pro Asp Phe Trp 
            100                 105                 110         


Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120         


<210> 1523
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H1"

<400> 1523
Tyr Ile Phe Thr Ser Tyr Gly Val Ser 
1               5                   


<210> 1524
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H1"

<400> 1524
tacatcttta ccagttatgg tgtcagt                                           27


<210> 1525
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H2"

<400> 1525
Trp Ile Ser Gly Tyr Asn Gly Asn Thr Tyr Tyr Asp Gln Lys Phe Gln 
1               5                   10                  15      


Gly 
    


<210> 1526
<211> 51
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H2"

<400> 1526
tggatcagcg gttacaatgg taacacatac tatgaccaga aattccaggg c                51


<210> 1527
<211> 15
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H3"

<400> 1527
Ala Arg Asp Ser Phe Ser Glu Thr Gly Thr Gly Phe Pro Asp Phe 
1               5                   10                  15  


<210> 1528
<211> 45
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H3"

<400> 1528
gcgagagatt ccttttcaga gactgggact ggatttcctg acttc                       45


<210> 1529
<211> 336
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region"

<400> 1529
gaaattgtgt tgacgcagtc tccactctcc ctgcccgtca cccttggaca gccggcctcc       60

atctcctgca ggtctagtca aagcctcgaa tacagtgatg gaaacaccta cttgaattgg      120

tttcagcaga ggccaggcca atctccaagg cgcctaattt ataaggtttc taaccgggac      180

tctggggtcc ccgacagatt cagcggcagt gggtcaggca ctgatttcac actgaaaatc      240

agcagggtgg aggctgagga tgttggagtt tattactgca tgcaagccac acaccggcct      300

cgcacgttcg gccaagggac caaagtggat atcaaa                                336


<210> 1530
<211> 112
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region"

<400> 1530
Glu Ile Val Leu Thr Gln Ser Pro Leu Ser Leu Pro Val Thr Leu Gly 
1               5                   10                  15      


Gln Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Glu Tyr Ser 
            20                  25                  30          


Asp Gly Asn Thr Tyr Leu Asn Trp Phe Gln Gln Arg Pro Gly Gln Ser 
        35                  40                  45              


Pro Arg Arg Leu Ile Tyr Lys Val Ser Asn Arg Asp Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Met Gln Ala 
                85                  90                  95      


Thr His Arg Pro Arg Thr Phe Gly Gln Gly Thr Lys Val Asp Ile Lys 
            100                 105                 110         


<210> 1531
<211> 16
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L1"

<400> 1531
Arg Ser Ser Gln Ser Leu Glu Tyr Ser Asp Gly Asn Thr Tyr Leu Asn 
1               5                   10                  15      


<210> 1532
<211> 48
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L1"

<400> 1532
aggtctagtc aaagcctcga atacagtgat ggaaacacct acttgaat                    48


<210> 1533
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L2"

<400> 1533
Lys Val Ser Asn Arg Asp Ser 
1               5           


<210> 1534
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L2"

<400> 1534
aaggtttcta accgggactc t                                                 21


<210> 1535
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L3"

<400> 1535
Met Gln Ala Thr His Arg Pro Arg Thr 
1               5                   


<210> 1536
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L3"

<400> 1536
atgcaagcca cacaccggcc tcgcacg                                           27


<210> 1537
<211> 357
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region"

<400> 1537
caggtccagc tggtgcagtc tggagcagag gtgaaaaagc ccggggagtc tctgaagatc       60

tcctgtaagg gttttggata cagctttaac agttactgga tcgcctgggt gcgccagatg      120

cccgggaaag gcctggagtg catgggcatc atctatcctg gcgactctga taccagatac      180

agcccgtcct tccaagggca ggtcaccatc tcagtcgaca agtccatcac taccgcctac      240

ctgcagtgga gcagcctgaa ggtctcggac accgccatgt attactgtgc gaaaagtaat      300

gtggggaata caggttggaa ctactggggc cagggaaccc tggtcaccgt ctcctca         357


<210> 1538
<211> 119
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region"

<400> 1538
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu 
1               5                   10                  15      


Ser Leu Lys Ile Ser Cys Lys Gly Phe Gly Tyr Ser Phe Asn Ser Tyr 
            20                  25                  30          


Trp Ile Ala Trp Val Arg Gln Met Pro Gly Lys Gly Leu Glu Cys Met 
        35                  40                  45              


Gly Ile Ile Tyr Pro Gly Asp Ser Asp Thr Arg Tyr Ser Pro Ser Phe 
    50                  55                  60                  


Gln Gly Gln Val Thr Ile Ser Val Asp Lys Ser Ile Thr Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Trp Ser Ser Leu Lys Val Ser Asp Thr Ala Met Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Ser Asn Val Gly Asn Thr Gly Trp Asn Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210> 1539
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H1"

<400> 1539
Tyr Ser Phe Asn Ser Tyr Trp Ile Ala 
1               5                   


<210> 1540
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H1"

<400> 1540
tacagcttta acagttactg gatcgcc                                           27


<210> 1541
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H2"

<400> 1541
Ile Ile Tyr Pro Gly Asp Ser Asp Thr Arg Tyr Ser Pro Ser Phe Gln 
1               5                   10                  15      


Gly 
    


<210> 1542
<211> 51
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H2"

<400> 1542
atcatctatc ctggcgactc tgataccaga tacagcccgt ccttccaagg g                51


<210> 1543
<211> 12
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H3"

<400> 1543
Ala Lys Ser Asn Val Gly Asn Thr Gly Trp Asn Tyr 
1               5                   10          


<210> 1544
<211> 36
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H3"

<400> 1544
gcgaaaagta atgtggggaa tacaggttgg aactac                                 36


<210> 1545
<211> 324
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region"

<400> 1545
gaaattgtat tgacacagtc tccagccacc ctgtctttgt ctccagggga aagagccacc       60

ctctcctgca gggccagtca cagtgttgcc accgacctag cctggtacca gcagaaacct      120

ggccaggctc ccaggctcct catctatgat gcatccaaga gggccactga cgtcccagcc      180

aggttcagtg gcagtgggtc tgggacagac ttcactctca ccatcagcag cctagagcct      240

gaagatgttg cagtttatta ctgtcaggaa gttaggaact ggcctccgtg cacttttggc      300

caggggacca aagtggatat caaa                                             324


<210> 1546
<211> 108
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region"

<400> 1546
Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser His Ser Val Ala Thr Asp 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 
        35                  40                  45              


Tyr Asp Ala Ser Lys Arg Ala Thr Asp Val Pro Ala Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu Pro 
65                  70                  75                  80  


Glu Asp Val Ala Val Tyr Tyr Cys Gln Glu Val Arg Asn Trp Pro Pro 
                85                  90                  95      


Cys Thr Phe Gly Gln Gly Thr Lys Val Asp Ile Lys 
            100                 105             


<210> 1547
<211> 11
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L1"

<400> 1547
Arg Ala Ser His Ser Val Ala Thr Asp Leu Ala 
1               5                   10      


<210> 1548
<211> 33
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L1"

<400> 1548
agggccagtc acagtgttgc caccgaccta gcc                                    33


<210> 1549
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L2"

<400> 1549
Asp Ala Ser Lys Arg Ala Thr 
1               5           


<210> 1550
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L2"

<400> 1550
gatgcatcca agagggccac t                                                 21


<210> 1551
<211> 10
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L3"

<400> 1551
Gln Glu Val Arg Asn Trp Pro Pro Cys Thr 
1               5                   10  


<210> 1552
<211> 30
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L3"

<400> 1552
caggaagtta ggaactggcc tccgtgcact                                        30


<210> 1553
<211> 369
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region"

<400> 1553
gaggtgcagc tgcaggagtc cggctctcga ctggtgaagc cttcacagac cctgtccctc       60

acctgctctg tctctggtgg ctccctcaac gcaggcggtt acctgtggag ctggatccgt      120

cagccaccag ggaagggcct ggagtgggtt gggtacatct atcctagtgg gactacctac      180

tacaacccgt ccctgcagag tcgaatcagc atttcacaag acaggtccag gaaccagttc      240

tccctgagcg tagcgtctgt gaccgccgcg gacacggccg tctattactg tgccagatgt      300

gggaatgagt acggtgaggt ccatcctttt gatatttggg gccaagggac cacggtcacc      360

gtctcctca                                                              369


<210> 1554
<211> 123
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region"

<400> 1554
Glu Val Gln Leu Gln Glu Ser Gly Ser Arg Leu Val Lys Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Ser Val Ser Gly Gly Ser Leu Asn Ala Gly 
            20                  25                  30          


Gly Tyr Leu Trp Ser Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu 
        35                  40                  45              


Trp Val Gly Tyr Ile Tyr Pro Ser Gly Thr Thr Tyr Tyr Asn Pro Ser 
    50                  55                  60                  


Leu Gln Ser Arg Ile Ser Ile Ser Gln Asp Arg Ser Arg Asn Gln Phe 
65                  70                  75                  80  


Ser Leu Ser Val Ala Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr 
                85                  90                  95      


Cys Ala Arg Cys Gly Asn Glu Tyr Gly Glu Val His Pro Phe Asp Ile 
            100                 105                 110         


Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120             


<210> 1555
<211> 11
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H1"

<400> 1555
Gly Ser Leu Asn Ala Gly Gly Tyr Leu Trp Ser 
1               5                   10      


<210> 1556
<211> 33
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H1"

<400> 1556
ggctccctca acgcaggcgg ttacctgtgg agc                                    33


<210> 1557
<211> 16
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H2"

<400> 1557
Tyr Ile Tyr Pro Ser Gly Thr Thr Tyr Tyr Asn Pro Ser Leu Gln Ser 
1               5                   10                  15      


<210> 1558
<211> 48
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H2"

<400> 1558
tacatctatc ctagtgggac tacctactac aacccgtccc tgcagagt                    48


<210> 1559
<211> 15
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H3"

<400> 1559
Ala Arg Cys Gly Asn Glu Tyr Gly Glu Val His Pro Phe Asp Ile 
1               5                   10                  15  


<210> 1560
<211> 45
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H3"

<400> 1560
gccagatgtg ggaatgagta cggtgaggtc catccttttg atatt                       45


<210> 1561
<211> 324
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region"

<400> 1561
gaaattgtat tgacacagtc tccaggcacc ctgtctttgt ctccagggga aagagccacc       60

ctctcctgcc ggggcagtcc tattgttggc aacaactact tagcctggta ccagcagaag      120

cctggccagg ctcccaggct cctcatctat gctgcatcca tcagggccac tggcatccca      180

gacaggttca gtggcagtgg gtctgggaca gacttcactc tcaccatcag cagactagag      240

cctgaagatt ttgcagtcta ttactgtcag caatatggca gctcaccgtg gacgttcggc      300

caagggacca aagtggatat caaa                                             324


<210> 1562
<211> 108
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region"

<400> 1562
Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Gly Ser Pro Ile Val Gly Asn Asn 
            20                  25                  30          


Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu 
        35                  40                  45              


Ile Tyr Ala Ala Ser Ile Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu 
65                  70                  75                  80  


Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Gly Ser Ser Pro 
                85                  90                  95      


Trp Thr Phe Gly Gln Gly Thr Lys Val Asp Ile Lys 
            100                 105             


<210> 1563
<211> 12
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L1"

<400> 1563
Arg Gly Ser Pro Ile Val Gly Asn Asn Tyr Leu Ala 
1               5                   10          


<210> 1564
<211> 36
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L1"

<400> 1564
cggggcagtc ctattgttgg caacaactac ttagcc                                 36


<210> 1565
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L2"

<400> 1565
Ala Ala Ser Ile Arg Ala Thr 
1               5           


<210> 1566
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L2"

<400> 1566
gctgcatcca tcagggccac t                                                 21


<210> 1567
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L3"

<400> 1567
Gln Gln Tyr Gly Ser Ser Pro Trp Thr 
1               5                   


<210> 1568
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L3"

<400> 1568
cagcaatatg gcagctcacc gtggacg                                           27


<210> 1569
<211> 366
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region"

<400> 1569
caggtgcagc tggtgcagtc tggagctgag gtgaagaagc ctggggcctc agtgaaggtc       60

tcctgcaagg cttctggtta catctttacc agttatggtg tcagctgggt gcgacaggcc      120

cctggacaag ggcttaagtg gatgggatgg atcagcggtt acaatggtaa cacaaactat      180

gaccagaaac tccagggcag agtcaccatg accacagaca catccacgag cacagcctac      240

atggagctga ggagcctgac atctgacgac acggccgttt attactgtgc gagagattca      300

ttttcagaga ctgggactgg gtttcctgac ttctggggcc agggaaccct ggtcaccgtc      360

tcctca                                                                 366


<210> 1570
<211> 122
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region"

<400> 1570
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Ile Phe Thr Ser Tyr 
            20                  25                  30          


Gly Val Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Lys Trp Met 
        35                  40                  45              


Gly Trp Ile Ser Gly Tyr Asn Gly Asn Thr Asn Tyr Asp Gln Lys Leu 
    50                  55                  60                  


Gln Gly Arg Val Thr Met Thr Thr Asp Thr Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Arg Ser Leu Thr Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Ser Phe Ser Glu Thr Gly Thr Gly Phe Pro Asp Phe Trp 
            100                 105                 110         


Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120         


<210> 1571
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H1"

<400> 1571
Tyr Ile Phe Thr Ser Tyr Gly Val Ser 
1               5                   


<210> 1572
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H1"

<400> 1572
tacatcttta ccagttatgg tgtcagc                                           27


<210> 1573
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H2"

<400> 1573
Trp Ile Ser Gly Tyr Asn Gly Asn Thr Asn Tyr Asp Gln Lys Leu Gln 
1               5                   10                  15      


Gly 
    


<210> 1574
<211> 51
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H2"

<400> 1574
tggatcagcg gttacaatgg taacacaaac tatgaccaga aactccaggg c                51


<210> 1575
<211> 15
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H3"

<400> 1575
Ala Arg Asp Ser Phe Ser Glu Thr Gly Thr Gly Phe Pro Asp Phe 
1               5                   10                  15  


<210> 1576
<211> 45
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H3"

<400> 1576
gcgagagatt cattttcaga gactgggact gggtttcctg acttc                       45


<210> 1577
<211> 336
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region"

<400> 1577
gacatccaga tgacccagtc tccactctcc ctgcccgtca cccttggaca gccggcctcc       60

atctcctgca ggtctagtca aagcctcgaa tacagtgatg gaaacaccta cttgaattgg      120

tttcagcaga ggccaggcca atctccaagg cgcctaattt ataaggtttc taaccgggac      180

tctggggtcc cagacagatt cagcggcagt gggtcaggca ctgatttcac actgaaaatc      240

agcagggtgg aggctgagga tgttggagtt tattactgca tgcaagccac acaccggcct      300

cgcacgttcg gccaagggac caagctggag atcaaa                                336


<210> 1578
<211> 112
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region"

<400> 1578
Asp Ile Gln Met Thr Gln Ser Pro Leu Ser Leu Pro Val Thr Leu Gly 
1               5                   10                  15      


Gln Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Glu Tyr Ser 
            20                  25                  30          


Asp Gly Asn Thr Tyr Leu Asn Trp Phe Gln Gln Arg Pro Gly Gln Ser 
        35                  40                  45              


Pro Arg Arg Leu Ile Tyr Lys Val Ser Asn Arg Asp Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Met Gln Ala 
                85                  90                  95      


Thr His Arg Pro Arg Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


<210> 1579
<211> 16
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L1"

<400> 1579
Arg Ser Ser Gln Ser Leu Glu Tyr Ser Asp Gly Asn Thr Tyr Leu Asn 
1               5                   10                  15      


<210> 1580
<211> 48
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L1"

<400> 1580
aggtctagtc aaagcctcga atacagtgat ggaaacacct acttgaat                    48


<210> 1581
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L2"

<400> 1581
Lys Val Ser Asn Arg Asp Ser 
1               5           


<210> 1582
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L2"

<400> 1582
aaggtttcta accgggactc t                                                 21


<210> 1583
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L3"

<400> 1583
Met Gln Ala Thr His Arg Pro Arg Thr 
1               5                   


<210> 1584
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L3"

<400> 1584
atgcaagcca cacaccggcc tcgcacg                                           27


<210> 1585
<211> 372
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region"

<400> 1585
gaggtgcagc tggtggagtc tgggggaggc gtggtccagc ctgggaggtc cctgagactc       60

tcctgtgcag cgtctggatt caccttcagt agtttttcta tgcactgggt ccgccaggct      120

ccaggcaagg ggctggagtg ggtggcactt atatcatctg acgagaggaa ttcatactac      180

gcagactccg tgaagggccg attcaccatc tccagagaca attccaagaa cacgctgtat      240

ctgcaaataa gcaggctgaa agtcgaggac acggctgtgt attattgtgc gagagaggca      300

tacgaagagt gggagctaac gatggggaac cttgaccact ggggccaggg aaccctggtc      360

accgtctcct ca                                                          372


<210> 1586
<211> 124
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region"

<400> 1586
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Phe 
            20                  25                  30          


Ser Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Leu Ile Ser Ser Asp Glu Arg Asn Ser Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Ile Ser Arg Leu Lys Val Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Glu Ala Tyr Glu Glu Trp Glu Leu Thr Met Gly Asn Leu Asp 
            100                 105                 110         


His Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 


<210> 1587
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H1"

<400> 1587
Phe Thr Phe Ser Ser Phe Ser Met His 
1               5                   


<210> 1588
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H1"

<400> 1588
ttcaccttca gtagtttttc tatgcac                                           27


<210> 1589
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H2"

<400> 1589
Leu Ile Ser Ser Asp Glu Arg Asn Ser Tyr Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210> 1590
<211> 51
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H2"

<400> 1590
cttatatcat ctgacgagag gaattcatac tacgcagact ccgtgaaggg c                51


<210> 1591
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H3"

<400> 1591
Ala Arg Glu Ala Tyr Glu Glu Trp Glu Leu Thr Met Gly Asn Leu Asp 
1               5                   10                  15      


His 
    


<210> 1592
<211> 51
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H3"

<400> 1592
gcgagagagg catacgaaga gtgggagcta acgatgggga accttgacca c                51


<210> 1593
<211> 321
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region"

<400> 1593
gacatccagt tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga cagagtcacc       60

atcacttgcc gggcaagtca gggcattgga aatgatttag gctggtatca gcagaaacca      120

gggaaagccc ctaagcgcct gatctatagt acatacagct tgcaaagtgg ggtcccatca      180

aggttcagcg gcagtggatc tgggacagaa ttcactctca caatcagcag cctgcagcct      240

gaagattttg caacttatta ctgtctacag cataatcgtt accccttcac tttcggccct      300

gggaccaagc tggagatcaa a                                                321


<210> 1594
<211> 107
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region"

<400> 1594
Asp Ile Gln Leu Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Gly Asn Asp 
            20                  25                  30          


Leu Gly Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Arg Leu Ile 
        35                  40                  45              


Tyr Ser Thr Tyr Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Leu Gln His Asn Arg Tyr Pro Phe 
                85                  90                  95      


Thr Phe Gly Pro Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210> 1595
<211> 11
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L1"

<400> 1595
Arg Ala Ser Gln Gly Ile Gly Asn Asp Leu Gly 
1               5                   10      


<210> 1596
<211> 33
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L1"

<400> 1596
cgggcaagtc agggcattgg aaatgattta ggc                                    33


<210> 1597
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L2"

<400> 1597
Ser Thr Tyr Ser Leu Gln Ser 
1               5           


<210> 1598
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L2"

<400> 1598
agtacataca gcttgcaaag t                                                 21


<210> 1599
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L3"

<400> 1599
Leu Gln His Asn Arg Tyr Pro Phe Thr 
1               5                   


<210> 1600
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L3"

<400> 1600
ctacagcata atcgttaccc cttcact                                           27


<210> 1601
<211> 360
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region"

<400> 1601
caggtgcagc tgcaggagtc gggcccagga ctggtgaagc cttcggagac cctgtccctc       60

acctgcactg tctctggtgc ctccgtcacc actaatactt actactggac ctggatccgg      120

cagcccccag ggaaggaact ggagtggatt ggatatatcc atcacactgg gaacacccac      180

tacaacccct ccctcgagag tcgactcacc atgtcactag acacgtccag gaaccagttc      240

tctctgaacc ttaggtctgc caccactgcg gacacggccg tttattactg tgcgagaggc      300

gaacattttg cgtactggtg gggaaactgg ggccagggag ccctggtcac cgtctcctca      360


<210> 1602
<211> 120
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region"

<400> 1602
Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Ala Ser Val Thr Thr Asn 
            20                  25                  30          


Thr Tyr Tyr Trp Thr Trp Ile Arg Gln Pro Pro Gly Lys Glu Leu Glu 
        35                  40                  45              


Trp Ile Gly Tyr Ile His His Thr Gly Asn Thr His Tyr Asn Pro Ser 
    50                  55                  60                  


Leu Glu Ser Arg Leu Thr Met Ser Leu Asp Thr Ser Arg Asn Gln Phe 
65                  70                  75                  80  


Ser Leu Asn Leu Arg Ser Ala Thr Thr Ala Asp Thr Ala Val Tyr Tyr 
                85                  90                  95      


Cys Ala Arg Gly Glu His Phe Ala Tyr Trp Trp Gly Asn Trp Gly Gln 
            100                 105                 110         


Gly Ala Leu Val Thr Val Ser Ser 
        115                 120 


<210> 1603
<211> 11
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H1"

<400> 1603
Ala Ser Val Thr Thr Asn Thr Tyr Tyr Trp Thr 
1               5                   10      


<210> 1604
<211> 33
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H1"

<400> 1604
gcctccgtca ccactaatac ttactactgg acc                                    33


<210> 1605
<211> 16
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H2"

<400> 1605
Tyr Ile His His Thr Gly Asn Thr His Tyr Asn Pro Ser Leu Glu Ser 
1               5                   10                  15      


<210> 1606
<211> 48
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H2"

<400> 1606
tatatccatc acactgggaa cacccactac aacccctccc tcgagagt                    48


<210> 1607
<211> 12
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H3"

<400> 1607
Ala Arg Gly Glu His Phe Ala Tyr Trp Trp Gly Asn 
1               5                   10          


<210> 1608
<211> 36
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H3"

<400> 1608
gcgagaggcg aacattttgc gtactggtgg ggaaac                                 36


<210> 1609
<211> 321
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region"

<400> 1609
gacatccggg tgacccagtc tccatcttcc gtgtctgcat ctgtaggaga cagagtcacc       60

atcacttgtc gggcgagtca gggtattgcc agatggttag cctggtatca gcagaaacca      120

gggaaagccc ctaaactcct gatctatgct gcatccagtt tgcaaggtgg ggtcccatca      180

aggttcagcg gcagtggata tgggacagat ttcactctca ccatcagcag cctgcagcct      240

gaagattttg caacttacta ctgtcaacag gctaacagtt ttcctcgaac gttcggccaa      300

gggaccaagg tggagatcaa a                                                321


<210> 1610
<211> 107
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region"

<400> 1610
Asp Ile Arg Val Thr Gln Ser Pro Ser Ser Val Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Ala Arg Trp 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Ser Leu Gln Gly Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Tyr Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ala Asn Ser Phe Pro Arg 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210> 1611
<211> 11
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L1"

<400> 1611
Arg Ala Ser Gln Gly Ile Ala Arg Trp Leu Ala 
1               5                   10      


<210> 1612
<211> 33
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L1"

<400> 1612
cgggcgagtc agggtattgc cagatggtta gcc                                    33


<210> 1613
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L2"

<400> 1613
Ala Ala Ser Ser Leu Gln Gly 
1               5           


<210> 1614
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L2"

<400> 1614
gctgcatcca gtttgcaagg t                                                 21


<210> 1615
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L3"

<400> 1615
Gln Gln Ala Asn Ser Phe Pro Arg Thr 
1               5                   


<210> 1616
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L3"

<400> 1616
caacaggcta acagttttcc tcgaacg                                           27


<210> 1617
<211> 363
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region"

<400> 1617
caggtccagc ttgtacagtc tgggcctgag gtgaagaagc ctggggcctc agtgaaggtc       60

tcctgcgagg cttctggata caccttcacc gacttctttg tgcactgggt gcgacaggcc      120

cctggtgagg ggcttgtgtg gttgggatgg gtcaaccctc tcagtggcgc cacaaagtat      180

gcacagaact ttcagggcag ggtcaccatg accagtgaca cgtccatcac cacagcctac      240

atggcactga gcagcctgag acatgacgac acggccgtct attactgtac gagccagact      300

tcaccttata ccccgggcgc tatgggcgtt tggggccaag ggaccacggt caccgtctcc      360

tca                                                                    363


<210> 1618
<211> 121
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region"

<400> 1618
Gln Val Gln Leu Val Gln Ser Gly Pro Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Glu Ala Ser Gly Tyr Thr Phe Thr Asp Phe 
            20                  25                  30          


Phe Val His Trp Val Arg Gln Ala Pro Gly Glu Gly Leu Val Trp Leu 
        35                  40                  45              


Gly Trp Val Asn Pro Leu Ser Gly Ala Thr Lys Tyr Ala Gln Asn Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Met Thr Ser Asp Thr Ser Ile Thr Thr Ala Tyr 
65                  70                  75                  80  


Met Ala Leu Ser Ser Leu Arg His Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Thr Ser Gln Thr Ser Pro Tyr Thr Pro Gly Ala Met Gly Val Trp Gly 
            100                 105                 110         


Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120     


<210> 1619
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H1"

<400> 1619
Tyr Thr Phe Thr Asp Phe Phe Val His 
1               5                   


<210> 1620
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H1"

<400> 1620
tacaccttca ccgacttctt tgtgcac                                           27


<210> 1621
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H2"

<400> 1621
Trp Val Asn Pro Leu Ser Gly Ala Thr Lys Tyr Ala Gln Asn Phe Gln 
1               5                   10                  15      


Gly 
    


<210> 1622
<211> 51
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H2"

<400> 1622
tgggtcaacc ctctcagtgg cgccacaaag tatgcacaga actttcaggg c                51


<210> 1623
<211> 14
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H3"

<400> 1623
Thr Ser Gln Thr Ser Pro Tyr Thr Pro Gly Ala Met Gly Val 
1               5                   10                  


<210> 1624
<211> 42
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H3"

<400> 1624
acgagccaga cttcacctta taccccgggc gctatgggcg tt                          42


<210> 1625
<211> 321
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region"

<400> 1625
gacatccggg tgacccagtc tccagcctcc ctgtctgcat ttgttggaga cagagtcacc       60

atcacttgcc gggcaagtcc ggccattagc ggctatttaa gttggtatca gcagaaggca      120

ggcaaagccc ctaagatcct gatctatgat gcatctaatt tgtatagtgg ggccccatca      180

cggttcagtg gcagtagatc tgggacagat ttcactctca ccatcaccag tctgcaacct      240

gaagattttg caacttacta ctgtcaacag acttacaatg gcctaatcgc tttcggccct      300

gggaccaagg tggaaatcaa a                                                321


<210> 1626
<211> 107
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region"

<400> 1626
Asp Ile Arg Val Thr Gln Ser Pro Ala Ser Leu Ser Ala Phe Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Pro Ala Ile Ser Gly Tyr 
            20                  25                  30          


Leu Ser Trp Tyr Gln Gln Lys Ala Gly Lys Ala Pro Lys Ile Leu Ile 
        35                  40                  45              


Tyr Asp Ala Ser Asn Leu Tyr Ser Gly Ala Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Arg Ser Gly Thr Asp Phe Thr Leu Thr Ile Thr Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Thr Tyr Asn Gly Leu Ile 
                85                  90                  95      


Ala Phe Gly Pro Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210> 1627
<211> 11
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L1"

<400> 1627
Arg Ala Ser Pro Ala Ile Ser Gly Tyr Leu Ser 
1               5                   10      


<210> 1628
<211> 33
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L1"

<400> 1628
cgggcaagtc cggccattag cggctattta agt                                    33


<210> 1629
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L2"

<400> 1629
Asp Ala Ser Asn Leu Tyr Ser 
1               5           


<210> 1630
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L2"

<400> 1630
gatgcatcta atttgtatag t                                                 21


<210> 1631
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L3"

<400> 1631
Gln Gln Thr Tyr Asn Gly Leu Ile Ala 
1               5                   


<210> 1632
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L3"

<400> 1632
caacagactt acaatggcct aatcgct                                           27


<210> 1633
<211> 366
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region"

<400> 1633
gaggtgcagc tgttggagtc tgggggaggc gtggtccagc ctgggaagtc cctgagactc       60

tcctgtgcag cctctggatt caccttcaat acctatgcta tacactgggt ccgccaggct      120

ccaggcaagg gcctggagtg ggtggcagct atatcatatg atggaagcaa tgaatactac      180

tcaaactccg tgaagggccg attcaccatc tccagagaca attccaagta cacgctggag      240

ctgcaaatga acagcctgag acctgaggac acggctgtgt attactgtgc gagaggcgcc      300

tcctactact atgtgagtag tgaccttggc tactggggcc agggaaccct ggtcaccgtc      360

tcctca                                                                 366


<210> 1634
<211> 122
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region"

<400> 1634
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Val Val Gln Pro Gly Lys 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Thr Tyr 
            20                  25                  30          


Ala Ile His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Ala Ile Ser Tyr Asp Gly Ser Asn Glu Tyr Tyr Ser Asn Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Tyr Thr Leu Glu 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Ala Ser Tyr Tyr Tyr Val Ser Ser Asp Leu Gly Tyr Trp 
            100                 105                 110         


Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120         


<210> 1635
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H1"

<400> 1635
Phe Thr Phe Asn Thr Tyr Ala Ile His 
1               5                   


<210> 1636
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H1"

<400> 1636
ttcaccttca atacctatgc tatacac                                           27


<210> 1637
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H2"

<400> 1637
Ala Ile Ser Tyr Asp Gly Ser Asn Glu Tyr Tyr Ser Asn Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210> 1638
<211> 51
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H2"

<400> 1638
gctatatcat atgatggaag caatgaatac tactcaaact ccgtgaaggg c                51


<210> 1639
<211> 15
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H3"

<400> 1639
Ala Arg Gly Ala Ser Tyr Tyr Tyr Val Ser Ser Asp Leu Gly Tyr 
1               5                   10                  15  


<210> 1640
<211> 45
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H3"

<400> 1640
gcgagaggcg cctcctacta ctatgtgagt agtgaccttg gctac                       45


<210> 1641
<211> 333
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region"

<400> 1641
cagtctgtcg tgacgcagcc gccctcagtg tctggggccc cagggcagag ggtcaccatc       60

tcctgcactg ggagcagctc caacatcggg tcaggttatg atgtgcactg gtaccagcag      120

cttccaggaa cagcccccaa agtcgtcatc tatggtaaca tcaatcggcc ctcaggggtc      180

cctgagcgat tctctggctc caagtctggc acctcagcct ccctggccat cactgggctc      240

caggctgagg atgaggctga ttattactgc cagtcctatg acagcctgag tgcctcttgg      300

gtgttcggcg gagggaccaa gctgaccgtc cta                                   333


<210> 1642
<211> 111
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region"

<400> 1642
Gln Ser Val Val Thr Gln Pro Pro Ser Val Ser Gly Ala Pro Gly Gln 
1               5                   10                  15      


Arg Val Thr Ile Ser Cys Thr Gly Ser Ser Ser Asn Ile Gly Ser Gly 
            20                  25                  30          


Tyr Asp Val His Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Val 
        35                  40                  45              


Val Ile Tyr Gly Asn Ile Asn Arg Pro Ser Gly Val Pro Glu Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Thr Gly Leu 
65                  70                  75                  80  


Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Gln Ser Tyr Asp Ser Leu 
                85                  90                  95      


Ser Ala Ser Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 110     


<210> 1643
<211> 14
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L1"

<400> 1643
Thr Gly Ser Ser Ser Asn Ile Gly Ser Gly Tyr Asp Val His 
1               5                   10                  


<210> 1644
<211> 42
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L1"

<400> 1644
actgggagca gctccaacat cgggtcaggt tatgatgtgc ac                          42


<210> 1645
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L2"

<400> 1645
Gly Asn Ile Asn Arg Pro Ser 
1               5           


<210> 1646
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L2"

<400> 1646
ggtaacatca atcggccctc a                                                 21


<210> 1647
<211> 11
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L3"

<400> 1647
Gln Ser Tyr Asp Ser Leu Ser Ala Ser Trp Val 
1               5                   10      


<210> 1648
<211> 33
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L3"

<400> 1648
cagtcctatg acagcctgag tgcctcttgg gtg                                    33


<210> 1649
<211> 375
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region"

<400> 1649
caggtccagc ttgtgcagtc tggggctgag gtgaagaagc ctgggtcctc ggtgaaggtc       60

tcctgcaagg cctctggagg caccttcagc ggccacgcta tcaactgggt gcgacaggcc      120

cctggacaag ggctcgaatg gatgggaggg atcatccata tatttgggac agtaaactac      180

gctccgaagt tccagggcag agtcacgatc accgcggacg catccacggg cacagtttac      240

atggagttga gcagcctgat atctgaggac acggccgtat attattgtgc gagagatgct      300

tacgaagtgt ggactggttc ttatctcccc ccttttgacg actggggcca gggaaccctg      360

gtcactgtct cctca                                                       375


<210> 1650
<211> 125
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region"

<400> 1650
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Gly His 
            20                  25                  30          


Ala Ile Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Gly Ile Ile His Ile Phe Gly Thr Val Asn Tyr Ala Pro Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Ala Asp Ala Ser Thr Gly Thr Val Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Ile Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Ala Tyr Glu Val Trp Thr Gly Ser Tyr Leu Pro Pro Phe 
            100                 105                 110         


Asp Asp Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125 


<210> 1651
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H1"

<400> 1651
Gly Thr Phe Ser Gly His Ala Ile Asn 
1               5                   


<210> 1652
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H1"

<400> 1652
ggcaccttca gcggccacgc tatcaac                                           27


<210> 1653
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H2"

<400> 1653
Gly Ile Ile His Ile Phe Gly Thr Val Asn Tyr Ala Pro Lys Phe Gln 
1               5                   10                  15      


Gly 
    


<210> 1654
<211> 51
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H2"

<400> 1654
gggatcatcc atatatttgg gacagtaaac tacgctccga agttccaggg c                51


<210> 1655
<211> 18
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H3"

<400> 1655
Ala Arg Asp Ala Tyr Glu Val Trp Thr Gly Ser Tyr Leu Pro Pro Phe 
1               5                   10                  15      


Asp Asp 
        


<210> 1656
<211> 54
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H3"

<400> 1656
gcgagagatg cttacgaagt gtggactggt tcttatctcc ccccttttga cgac             54


<210> 1657
<211> 324
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region"

<400> 1657
gatattgtga tgacgcagtc tccaggcacc ctgtctttgt ctcccgggga cagagtcacc       60

ctctcctgca gggccagtca gactgttaca agcagctact tagcctggta ccagcagaaa      120

cctggccagg ctcccaggct cctcatctat ggtgcattca ccagggccac tggcatccca      180

gacaggttca gtggcagtgg gtctgggaca gacttcactc tcagcatcag cagactggag      240

cctgaagatt ttgcagtata ttattgtcag cagtatggta gctcattcct cactttcggc      300

ggagggacca aagtggatat caaa                                             324


<210> 1658
<211> 108
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region"

<400> 1658
Asp Ile Val Met Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Asp Arg Val Thr Leu Ser Cys Arg Ala Ser Gln Thr Val Thr Ser Ser 
            20                  25                  30          


Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu 
        35                  40                  45              


Ile Tyr Gly Ala Phe Thr Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Ser Ile Ser Arg Leu Glu 
65                  70                  75                  80  


Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Gly Ser Ser Phe 
                85                  90                  95      


Leu Thr Phe Gly Gly Gly Thr Lys Val Asp Ile Lys 
            100                 105             


<210> 1659
<211> 12
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L1"

<400> 1659
Arg Ala Ser Gln Thr Val Thr Ser Ser Tyr Leu Ala 
1               5                   10          


<210> 1660
<211> 36
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L1"

<400> 1660
agggccagtc agactgttac aagcagctac ttagcc                                 36


<210> 1661
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L2"

<400> 1661
Gly Ala Phe Thr Arg Ala Thr 
1               5           


<210> 1662
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L2"

<400> 1662
ggtgcattca ccagggccac t                                                 21


<210> 1663
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L3"

<400> 1663
Gln Gln Tyr Gly Ser Ser Phe Leu Thr 
1               5                   


<210> 1664
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L3"

<400> 1664
cagcagtatg gtagctcatt cctcact                                           27


<210> 1665
<211> 369
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region"

<400> 1665
gaggtgcagc tggtggaatc tgggggaggc ctggtcaggc ctggggggtc cctgagactc       60

tcctgtgcag cctctggatt cagtctcagt agttacggca tgagttgggt ccgccaggct      120

ccagggaagg gtctggagtg ggtctcatcc attactgccg gcagtagtta cataaattac      180

gctgactcag tgaagggccg gttcaccatc tccagagaca acgccaagag ttcactgttc      240

ctgcaaatga ccagcctgag agtcgaggac acggctgttt atttctgtgt gagagaggcg      300

tatgccagct cgtcggccct ttactggttc gacccctggg gccagggaac cctggtcacc      360

gtctcctca                                                              369


<210> 1666
<211> 123
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region"

<400> 1666
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Arg Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ser Leu Ser Ser Tyr 
            20                  25                  30          


Gly Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ser Ile Thr Ala Gly Ser Ser Tyr Ile Asn Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Ser Ser Leu Phe 
65                  70                  75                  80  


Leu Gln Met Thr Ser Leu Arg Val Glu Asp Thr Ala Val Tyr Phe Cys 
                85                  90                  95      


Val Arg Glu Ala Tyr Ala Ser Ser Ser Ala Leu Tyr Trp Phe Asp Pro 
            100                 105                 110         


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120             


<210> 1667
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H1"

<400> 1667
Phe Ser Leu Ser Ser Tyr Gly Met Ser 
1               5                   


<210> 1668
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H1"

<400> 1668
ttcagtctca gtagttacgg catgagt                                           27


<210> 1669
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H2"

<400> 1669
Ser Ile Thr Ala Gly Ser Ser Tyr Ile Asn Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210> 1670
<211> 51
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H2"

<400> 1670
tccattactg ccggcagtag ttacataaat tacgctgact cagtgaaggg c                51


<210> 1671
<211> 16
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H3"

<400> 1671
Val Arg Glu Ala Tyr Ala Ser Ser Ser Ala Leu Tyr Trp Phe Asp Pro 
1               5                   10                  15      


<210> 1672
<211> 48
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H3"

<400> 1672
gtgagagagg cgtatgccag ctcgtcggcc ctttactggt tcgacccc                    48


<210> 1673
<211> 333
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region"

<400> 1673
cagtctgtcc tgacgcagcc gccctcagtc tctggggccc cagggcagag ggtcaccatc       60

tcctgcactg ggagcagctc caatctcggg gcgggttatg ttgttcactg gtaccagcaa      120

cttccaggaa catcccccaa actcctcatc tatggtaaca ccgatcggcc ctcaggggtc      180

cccgaccgat tctctggctc caagtctggc acctcagcct ccctggccat cagtgggctc      240

caggctgagg atgaggctga ttattactgc cagtcctatg acagtagcct gagtggctgg      300

gtgttcggcg gagggaccaa gctgaccgtc cta                                   333


<210> 1674
<211> 111
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region"

<400> 1674
Gln Ser Val Leu Thr Gln Pro Pro Ser Val Ser Gly Ala Pro Gly Gln 
1               5                   10                  15      


Arg Val Thr Ile Ser Cys Thr Gly Ser Ser Ser Asn Leu Gly Ala Gly 
            20                  25                  30          


Tyr Val Val His Trp Tyr Gln Gln Leu Pro Gly Thr Ser Pro Lys Leu 
        35                  40                  45              


Leu Ile Tyr Gly Asn Thr Asp Arg Pro Ser Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu 
65                  70                  75                  80  


Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Gln Ser Tyr Asp Ser Ser 
                85                  90                  95      


Leu Ser Gly Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 110     


<210> 1675
<211> 14
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L1"

<400> 1675
Thr Gly Ser Ser Ser Asn Leu Gly Ala Gly Tyr Val Val His 
1               5                   10                  


<210> 1676
<211> 42
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L1"

<400> 1676
actgggagca gctccaatct cggggcgggt tatgttgttc ac                          42


<210> 1677
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L2"

<400> 1677
Gly Asn Thr Asp Arg Pro Ser 
1               5           


<210> 1678
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L2"

<400> 1678
ggtaacaccg atcggccctc a                                                 21


<210> 1679
<211> 11
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L3"

<400> 1679
Gln Ser Tyr Asp Ser Ser Leu Ser Gly Trp Val 
1               5                   10      


<210> 1680
<211> 33
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L3"

<400> 1680
cagtcctatg acagtagcct gagtggctgg gtg                                    33


<210> 1681
<211> 393
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region"

<400> 1681
gaggtgcagc tggtggagtc tgggggaggc ttagtacagc ctggggggtc cctgcgactc       60

tcctgtgcag cctctggatt cagcttcaat acctatagca tgaactgggt ccgccaggct      120

ccagggaagg gattggagtg gctttcattc attagtagta gtagtcatac cctatactac      180

gcagactctg tgaagggccg attcaccgtc ttcagagaca atgccaagca ctcgctcttt      240

ctgcaaatga acggcctgag agacgaggac acggctgttt atttctgtgc gagatccctt      300

ggttcgggga attatgataa cgaagatcag acattttact actactacgg tatggacgtc      360

tggggccaag ggaccacggt caccgtctcc tca                                   393


<210> 1682
<211> 131
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region"

<400> 1682
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ser Phe Asn Thr Tyr 
            20                  25                  30          


Ser Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Leu 
        35                  40                  45              


Ser Phe Ile Ser Ser Ser Ser His Thr Leu Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Val Phe Arg Asp Asn Ala Lys His Ser Leu Phe 
65                  70                  75                  80  


Leu Gln Met Asn Gly Leu Arg Asp Glu Asp Thr Ala Val Tyr Phe Cys 
                85                  90                  95      


Ala Arg Ser Leu Gly Ser Gly Asn Tyr Asp Asn Glu Asp Gln Thr Phe 
            100                 105                 110         


Tyr Tyr Tyr Tyr Gly Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr 
        115                 120                 125             


Val Ser Ser 
    130     


<210> 1683
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H1"

<400> 1683
Phe Ser Phe Asn Thr Tyr Ser Met Asn 
1               5                   


<210> 1684
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H1"

<400> 1684
ttcagcttca atacctatag catgaac                                           27


<210> 1685
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H2"

<400> 1685
Phe Ile Ser Ser Ser Ser His Thr Leu Tyr Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210> 1686
<211> 51
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H2"

<400> 1686
ttcattagta gtagtagtca taccctatac tacgcagact ctgtgaaggg c                51


<210> 1687
<211> 24
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H3"

<400> 1687
Ala Arg Ser Leu Gly Ser Gly Asn Tyr Asp Asn Glu Asp Gln Thr Phe 
1               5                   10                  15      


Tyr Tyr Tyr Tyr Gly Met Asp Val 
            20                  


<210> 1688
<211> 72
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H3"

<400> 1688
gcgagatccc ttggttcggg gaattatgat aacgaagatc agacatttta ctactactac       60

ggtatggacg tc                                                           72


<210> 1689
<211> 339
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region"

<400> 1689
gaaacgacac tcacgcagtc tccactctcc ctgcccgtca cccctggaga gccggcctcc       60

atatcctgcc ggtctagtca gagcctcctg tttcatagta atggacacaa ttatttggat      120

tggtacctgc agaagccagg gcagtctcca caactcctga tccatttggg ttctaatcgg      180

gcctccggag tccctgacag gttcagtggc agtggatcag gcacagattt tacactgaaa      240

atcagcagag tggagcctga ggatgttggg gtttattact gtatgcaagc tctacaaact      300

ccgtacactt ttggccaggg gaccaaggtg gagatcaaa                             339


<210> 1690
<211> 113
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region"

<400> 1690
Glu Thr Thr Leu Thr Gln Ser Pro Leu Ser Leu Pro Val Thr Pro Gly 
1               5                   10                  15      


Glu Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Leu Phe His 
            20                  25                  30          


Ser Asn Gly His Asn Tyr Leu Asp Trp Tyr Leu Gln Lys Pro Gly Gln 
        35                  40                  45              


Ser Pro Gln Leu Leu Ile His Leu Gly Ser Asn Arg Ala Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys 
65                  70                  75                  80  


Ile Ser Arg Val Glu Pro Glu Asp Val Gly Val Tyr Tyr Cys Met Gln 
                85                  90                  95      


Ala Leu Gln Thr Pro Tyr Thr Phe Gly Gln Gly Thr Lys Val Glu Ile 
            100                 105                 110         


Lys 
    


<210> 1691
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L1"

<400> 1691
Arg Ser Ser Gln Ser Leu Leu Phe His Ser Asn Gly His Asn Tyr Leu 
1               5                   10                  15      


Asp 
    


<210> 1692
<211> 51
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L1"

<400> 1692
cggtctagtc agagcctcct gtttcatagt aatggacaca attatttgga t                51


<210> 1693
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L2"

<400> 1693
Leu Gly Ser Asn Arg Ala Ser 
1               5           


<210> 1694
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L2"

<400> 1694
ttgggttcta atcgggcctc c                                                 21


<210> 1695
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L3"

<400> 1695
Met Gln Ala Leu Gln Thr Pro Tyr Thr 
1               5                   


<210> 1696
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L3"

<400> 1696
atgcaagctc tacaaactcc gtacact                                           27


<210> 1697
<211> 372
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region"

<400> 1697
caggtgcagc tgcaggagtc gggcccagga cgggtgaagc cttcacagac cctgtccctc       60

acctgcactg tctctggtgt ctccgtcacc attaatgatt actactggac ttggctccgc      120

cagtccccag ggaaaggcct ggagtggatt ggaaacatct ataacagtgg gagcacctac      180

cagaacccgt ccctccagag tcgagttacc atgtcagtgg acacggccaa gaaccacttc      240

tccctgaagc tgacctctgt cactgccgca gatacggccg tctattactg tgccagagat      300

ttaggcactg ccaacaacta ctacttcggt atggacgtct ggggcctagg gaccacggtc      360

accgtctcct ca                                                          372


<210> 1698
<211> 124
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region"

<400> 1698
Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Arg Val Lys Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Val Ser Val Thr Ile Asn 
            20                  25                  30          


Asp Tyr Tyr Trp Thr Trp Leu Arg Gln Ser Pro Gly Lys Gly Leu Glu 
        35                  40                  45              


Trp Ile Gly Asn Ile Tyr Asn Ser Gly Ser Thr Tyr Gln Asn Pro Ser 
    50                  55                  60                  


Leu Gln Ser Arg Val Thr Met Ser Val Asp Thr Ala Lys Asn His Phe 
65                  70                  75                  80  


Ser Leu Lys Leu Thr Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr 
                85                  90                  95      


Cys Ala Arg Asp Leu Gly Thr Ala Asn Asn Tyr Tyr Phe Gly Met Asp 
            100                 105                 110         


Val Trp Gly Leu Gly Thr Thr Val Thr Val Ser Ser 
        115                 120                 


<210> 1699
<211> 11
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H1"

<400> 1699
Val Ser Val Thr Ile Asn Asp Tyr Tyr Trp Thr 
1               5                   10      


<210> 1700
<211> 33
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H1"

<400> 1700
gtctccgtca ccattaatga ttactactgg act                                    33


<210> 1701
<211> 16
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H2"

<400> 1701
Asn Ile Tyr Asn Ser Gly Ser Thr Tyr Gln Asn Pro Ser Leu Gln Ser 
1               5                   10                  15      


<210> 1702
<211> 48
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H2"

<400> 1702
aacatctata acagtgggag cacctaccag aacccgtccc tccagagt                    48


<210> 1703
<211> 16
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H3"

<400> 1703
Ala Arg Asp Leu Gly Thr Ala Asn Asn Tyr Tyr Phe Gly Met Asp Val 
1               5                   10                  15      


<210> 1704
<211> 48
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H3"

<400> 1704
gccagagatt taggcactgc caacaactac tacttcggta tggacgtc                    48


<210> 1705
<211> 324
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region"

<400> 1705
gatattgtgc tgacgcagtc tccagccacc ctgtctttgt ctccagggga aagagccact       60

ctctcctgca gggccagtca gagtgttagc acctacttag cctggtacca acagaaacct      120

ggccaggctc ccaggctcct catctataat ggatccaaca gggtcactgg caccccagcc      180

aggttcagtg gcagtgggtc tgggacagac ttcactctca ccatcagcag cgtagagcct      240

gaagattttg cagtttatta ctgtcagcag cgtagcaact ggcctccgta cacttttggc      300

caggggacca aggtggagat caaa                                             324


<210> 1706
<211> 108
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region"

<400> 1706
Asp Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Thr Tyr 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 
        35                  40                  45              


Tyr Asn Gly Ser Asn Arg Val Thr Gly Thr Pro Ala Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Val Glu Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Arg Ser Asn Trp Pro Pro 
                85                  90                  95      


Tyr Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105             


<210> 1707
<211> 11
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L1"

<400> 1707
Arg Ala Ser Gln Ser Val Ser Thr Tyr Leu Ala 
1               5                   10      


<210> 1708
<211> 33
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L1"

<400> 1708
agggccagtc agagtgttag cacctactta gcc                                    33


<210> 1709
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L2"

<400> 1709
Asn Gly Ser Asn Arg Val Thr 
1               5           


<210> 1710
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L2"

<400> 1710
aatggatcca acagggtcac t                                                 21


<210> 1711
<211> 10
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L3"

<400> 1711
Gln Gln Arg Ser Asn Trp Pro Pro Tyr Thr 
1               5                   10  


<210> 1712
<211> 30
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L3"

<400> 1712
cagcagcgta gcaactggcc tccgtacact                                        30


<210> 1713
<211> 369
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region"

<400> 1713
gaggtgcagc tggtggagtc gggccctgga ctggtgaagc cttcagagac cctgtccctc       60

agttgcattg tctctggtga ctccatcacc agtaatgatt actactggag ttggatccgc      120

cagtccccag ggaagggcct ggagtggatt gggtacatct atcacagcgg ggccaccttc      180

tacactccgt ccctacggag tcgagtgacc atatcgacag acaggtccaa gaaccagttc      240

tccctgagac tgtcgtctgt gaccgccgca gacacggccg tatattattg tgccagtgga      300

cctgtgggga tggctacaag caactggttc gacccctggg gccagggaac cctggtcacc      360

gtctcttca                                                              369


<210> 1714
<211> 123
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region"

<400> 1714
Glu Val Gln Leu Val Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Ser Cys Ile Val Ser Gly Asp Ser Ile Thr Ser Asn 
            20                  25                  30          


Asp Tyr Tyr Trp Ser Trp Ile Arg Gln Ser Pro Gly Lys Gly Leu Glu 
        35                  40                  45              


Trp Ile Gly Tyr Ile Tyr His Ser Gly Ala Thr Phe Tyr Thr Pro Ser 
    50                  55                  60                  


Leu Arg Ser Arg Val Thr Ile Ser Thr Asp Arg Ser Lys Asn Gln Phe 
65                  70                  75                  80  


Ser Leu Arg Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr 
                85                  90                  95      


Cys Ala Ser Gly Pro Val Gly Met Ala Thr Ser Asn Trp Phe Asp Pro 
            100                 105                 110         


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120             


<210> 1715
<211> 11
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H1"

<400> 1715
Asp Ser Ile Thr Ser Asn Asp Tyr Tyr Trp Ser 
1               5                   10      


<210> 1716
<211> 33
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H1"

<400> 1716
gactccatca ccagtaatga ttactactgg agt                                    33


<210> 1717
<211> 16
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H2"

<400> 1717
Tyr Ile Tyr His Ser Gly Ala Thr Phe Tyr Thr Pro Ser Leu Arg Ser 
1               5                   10                  15      


<210> 1718
<211> 48
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H2"

<400> 1718
tacatctatc acagcggggc caccttctac actccgtccc tacggagt                    48


<210> 1719
<211> 15
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H3"

<400> 1719
Ala Ser Gly Pro Val Gly Met Ala Thr Ser Asn Trp Phe Asp Pro 
1               5                   10                  15  


<210> 1720
<211> 45
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H3"

<400> 1720
gccagtggac ctgtggggat ggctacaagc aactggttcg acccc                       45


<210> 1721
<211> 327
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region"

<400> 1721
cagcctgtgc tgactcagcc accctcagtg tcagtcgccc cgggaaagac ggccactctt       60

acgtgtgggg gagacatcat tagaactaac agtgtgaact ggtaccagca gaagccaggc      120

caggcccctg tattgatcat atattatgat agcgaccggc cctcagggat ccctgggcga      180

ttctctgcct ccaactctgg gagcgcggcc accctgacca tcagcagggt cgaagccggg      240

gatgaggccg actattactg tcaggtgtgg gacagcagta ctgattatca cgtggttttc      300

ggcggaggga ccaagctcac cgtccta                                          327


<210> 1722
<211> 109
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region"

<400> 1722
Gln Pro Val Leu Thr Gln Pro Pro Ser Val Ser Val Ala Pro Gly Lys 
1               5                   10                  15      


Thr Ala Thr Leu Thr Cys Gly Gly Asp Ile Ile Arg Thr Asn Ser Val 
            20                  25                  30          


Asn Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Val Leu Ile Ile Tyr 
        35                  40                  45              


Tyr Asp Ser Asp Arg Pro Ser Gly Ile Pro Gly Arg Phe Ser Ala Ser 
    50                  55                  60                  


Asn Ser Gly Ser Ala Ala Thr Leu Thr Ile Ser Arg Val Glu Ala Gly 
65                  70                  75                  80  


Asp Glu Ala Asp Tyr Tyr Cys Gln Val Trp Asp Ser Ser Thr Asp Tyr 
                85                  90                  95      


His Val Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 


<210> 1723
<211> 11
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L1"

<400> 1723
Gly Gly Asp Ile Ile Arg Thr Asn Ser Val Asn 
1               5                   10      


<210> 1724
<211> 33
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L1"

<400> 1724
gggggagaca tcattagaac taacagtgtg aac                                    33


<210> 1725
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L2"

<400> 1725
Tyr Asp Ser Asp Arg Pro Ser 
1               5           


<210> 1726
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L2"

<400> 1726
tatgatagcg accggccctc a                                                 21


<210> 1727
<211> 12
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L3"

<400> 1727
Gln Val Trp Asp Ser Ser Thr Asp Tyr His Val Val 
1               5                   10          


<210> 1728
<211> 36
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L3"

<400> 1728
caggtgtggg acagcagtac tgattatcac gtggtt                                 36


<210> 1729
<211> 390
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region"

<400> 1729
caggtccagc tggtacagtc tggggctgag gtgaagaagc ctggggcctc agtgaaggtt       60

tcctgcaagg catctggata catcttcacc ggttatttta tacactgggt gcgacaggcc      120

cccggacaag ggcttgagtg gatgggagta atcaatccca gaggtggaag cacaagctac      180

gcacaaaagt tccagggcag agtcgctgtg tccagggaca cgtccacgac tacagtctac      240

atggagctga acagcctgag atctgaggac acggccgtat attactgtgc gagagccccg      300

agccacgatg agtgggtcgc aatttcccga aataacgatg ttgtggggtt cgacgcctgg      360

ggccagggaa ccctggtcac cgtctcctca                                       390


<210> 1730
<211> 130
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region"

<400> 1730
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Ile Phe Thr Gly Tyr 
            20                  25                  30          


Phe Ile His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Val Ile Asn Pro Arg Gly Gly Ser Thr Ser Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Ala Val Ser Arg Asp Thr Ser Thr Thr Thr Val Tyr 
65                  70                  75                  80  


Met Glu Leu Asn Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ala Pro Ser His Asp Glu Trp Val Ala Ile Ser Arg Asn Asn 
            100                 105                 110         


Asp Val Val Gly Phe Asp Ala Trp Gly Gln Gly Thr Leu Val Thr Val 
        115                 120                 125             


Ser Ser 
    130 


<210> 1731
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H1"

<400> 1731
Tyr Ile Phe Thr Gly Tyr Phe Ile His 
1               5                   


<210> 1732
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H1"

<400> 1732
tacatcttca ccggttattt tatacac                                           27


<210> 1733
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H2"

<400> 1733
Val Ile Asn Pro Arg Gly Gly Ser Thr Ser Tyr Ala Gln Lys Phe Gln 
1               5                   10                  15      


Gly 
    


<210> 1734
<211> 51
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H2"

<400> 1734
gtaatcaatc ccagaggtgg aagcacaagc tacgcacaaa agttccaggg c                51


<210> 1735
<211> 23
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H3"

<400> 1735
Ala Arg Ala Pro Ser His Asp Glu Trp Val Ala Ile Ser Arg Asn Asn 
1               5                   10                  15      


Asp Val Val Gly Phe Asp Ala 
            20              


<210> 1736
<211> 69
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H3"

<400> 1736
gcgagagccc cgagccacga tgagtgggtc gcaatttccc gaaataacga tgttgtgggg       60

ttcgacgcc                                                               69


<210> 1737
<211> 333
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region"

<400> 1737
cagtctgtcc tgactcagcc gccctcagtg tctggggccc cagggcagag ggtcaccatc       60

tcctgcactg ggggcagctc caacatcggg gcagattatg acgtacactg gtaccagcag      120

cctccaggaa cagcccccaa actcctcata tttgctaaca acaatcgacc ctcaggggtc      180

cctggccgat tctctggctc caagtctggc acctcagcct ccctggccat cactgggctc      240

caggctgagg atgaggctga ttattactgc cagtcctatg acagcagcct gagtgcttgg      300

gtgttcggcg gggggaccaa gctgaccgtc cta                                   333


<210> 1738
<211> 111
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region"

<400> 1738
Gln Ser Val Leu Thr Gln Pro Pro Ser Val Ser Gly Ala Pro Gly Gln 
1               5                   10                  15      


Arg Val Thr Ile Ser Cys Thr Gly Gly Ser Ser Asn Ile Gly Ala Asp 
            20                  25                  30          


Tyr Asp Val His Trp Tyr Gln Gln Pro Pro Gly Thr Ala Pro Lys Leu 
        35                  40                  45              


Leu Ile Phe Ala Asn Asn Asn Arg Pro Ser Gly Val Pro Gly Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Thr Gly Leu 
65                  70                  75                  80  


Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Gln Ser Tyr Asp Ser Ser 
                85                  90                  95      


Leu Ser Ala Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 110     


<210> 1739
<211> 14
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L1"

<400> 1739
Thr Gly Gly Ser Ser Asn Ile Gly Ala Asp Tyr Asp Val His 
1               5                   10                  


<210> 1740
<211> 42
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L1"

<400> 1740
actgggggca gctccaacat cggggcagat tatgacgtac ac                          42


<210> 1741
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L2"

<400> 1741
Ala Asn Asn Asn Arg Pro Ser 
1               5           


<210> 1742
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L2"

<400> 1742
gctaacaaca atcgaccctc a                                                 21


<210> 1743
<211> 11
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L3"

<400> 1743
Gln Ser Tyr Asp Ser Ser Leu Ser Ala Trp Val 
1               5                   10      


<210> 1744
<211> 33
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L3"

<400> 1744
cagtcctatg acagcagcct gagtgcttgg gtg                                    33


<210> 1745
<211> 372
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region"

<400> 1745
gaggtgcagc tggtggagtc tgggggaggc ctggtcaagc ctggggggtc cctgagactc       60

tcctgtgcag cctctggatt caccctcagt agttatgcca tgaactgggt ccgccaggct      120

ccagggaagg gtctggagtg ggtctcatcc attagtgctg gaagtagtta catcgactac      180

gcagactcag tgaagggccg attcaccatc tccagagaca acgccaagaa ctctctgtat      240

ctgcaaatga acaacctgag agccgaggac acggctctgt attactgtgc gagagaagtt      300

ttaccagcaa ccgctatagg aggcgcctgg ctcgacccct ggggccaggg aaccctggtc      360

actgtctcct ca                                                          372


<210> 1746
<211> 124
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region"

<400> 1746
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Leu Ser Ser Tyr 
            20                  25                  30          


Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ser Ile Ser Ala Gly Ser Ser Tyr Ile Asp Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Asn Leu Arg Ala Glu Asp Thr Ala Leu Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Glu Val Leu Pro Ala Thr Ala Ile Gly Gly Ala Trp Leu Asp 
            100                 105                 110         


Pro Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 


<210> 1747
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H1"

<400> 1747
Phe Thr Leu Ser Ser Tyr Ala Met Asn 
1               5                   


<210> 1748
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H1"

<400> 1748
ttcaccctca gtagttatgc catgaac                                           27


<210> 1749
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H2"

<400> 1749
Ser Ile Ser Ala Gly Ser Ser Tyr Ile Asp Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210> 1750
<211> 51
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H2"

<400> 1750
tccattagtg ctggaagtag ttacatcgac tacgcagact cagtgaaggg c                51


<210> 1751
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H3"

<400> 1751
Ala Arg Glu Val Leu Pro Ala Thr Ala Ile Gly Gly Ala Trp Leu Asp 
1               5                   10                  15      


Pro 
    


<210> 1752
<211> 51
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H3"

<400> 1752
gcgagagaag ttttaccagc aaccgctata ggaggcgcct ggctcgaccc c                51


<210> 1753
<211> 336
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region"

<400> 1753
cagtctgtcc tgacgcagcc gccctcagtg tctggggccc cagggcagac ggtcaccatc       60

tcctgcactg ggagcagctc caacatcggg gctggatatg atgtccactg gtaccggcag      120

cttccaggaa cagcccccaa actcctcatc tattctaaca acaatcggcc ctcaggggtc      180

cctgaccgat tctctggctc caagtctgac acctcagcct ccctggccat cactgggctc      240

caggctgggg atgaggctga ttattactgc cagtcctatg acatcagcct gagtgcctct      300

tatgtcttcg gaactgggac caaggtcacc gtccta                                336


<210> 1754
<211> 112
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region"

<400> 1754
Gln Ser Val Leu Thr Gln Pro Pro Ser Val Ser Gly Ala Pro Gly Gln 
1               5                   10                  15      


Thr Val Thr Ile Ser Cys Thr Gly Ser Ser Ser Asn Ile Gly Ala Gly 
            20                  25                  30          


Tyr Asp Val His Trp Tyr Arg Gln Leu Pro Gly Thr Ala Pro Lys Leu 
        35                  40                  45              


Leu Ile Tyr Ser Asn Asn Asn Arg Pro Ser Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Asp Thr Ser Ala Ser Leu Ala Ile Thr Gly Leu 
65                  70                  75                  80  


Gln Ala Gly Asp Glu Ala Asp Tyr Tyr Cys Gln Ser Tyr Asp Ile Ser 
                85                  90                  95      


Leu Ser Ala Ser Tyr Val Phe Gly Thr Gly Thr Lys Val Thr Val Leu 
            100                 105                 110         


<210> 1755
<211> 14
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L1"

<400> 1755
Thr Gly Ser Ser Ser Asn Ile Gly Ala Gly Tyr Asp Val His 
1               5                   10                  


<210> 1756
<211> 42
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L1"

<400> 1756
actgggagca gctccaacat cggggctgga tatgatgtcc ac                          42


<210> 1757
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L2"

<400> 1757
Ser Asn Asn Asn Arg Pro Ser 
1               5           


<210> 1758
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L2"

<400> 1758
tctaacaaca atcggccctc a                                                 21


<210> 1759
<211> 12
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L3"

<400> 1759
Gln Ser Tyr Asp Ile Ser Leu Ser Ala Ser Tyr Val 
1               5                   10          


<210> 1760
<211> 36
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L3"

<400> 1760
cagtcctatg acatcagcct gagtgcctct tatgtc                                 36


<210> 1761
<211> 369
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region"

<400> 1761
caggtccagc tggtgcagtc tggagctgag gtgaagaagc ctggggcctc agtgaaggtc       60

tcctgcaagg cttctggtta cacctttacc aactatggtt tcagctgggt gcgacaggcc      120

cctggacaag ggcttgagtg gatgggatgg atcctcactc acaatggtta cacaaactat      180

gcacagaagt tccaggacag agtcaccatg aagacagaca catccacgag cacagtctac      240

atggagctga ggagcctgag atctgtcgac acggccgtgt attactgtgc gagaattggc      300

catgttacag ccgtggctgg tgcccctcct gactactggg gccagggaac cctggtcacc      360

gtctcctca                                                              369


<210> 1762
<211> 123
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region"

<400> 1762
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asn Tyr 
            20                  25                  30          


Gly Phe Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Leu Thr His Asn Gly Tyr Thr Asn Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Asp Arg Val Thr Met Lys Thr Asp Thr Ser Thr Ser Thr Val Tyr 
65                  70                  75                  80  


Met Glu Leu Arg Ser Leu Arg Ser Val Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ile Gly His Val Thr Ala Val Ala Gly Ala Pro Pro Asp Tyr 
            100                 105                 110         


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120             


<210> 1763
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H1"

<400> 1763
Tyr Thr Phe Thr Asn Tyr Gly Phe Ser 
1               5                   


<210> 1764
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H1"

<400> 1764
tacaccttta ccaactatgg tttcagc                                           27


<210> 1765
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H2"

<400> 1765
Trp Ile Leu Thr His Asn Gly Tyr Thr Asn Tyr Ala Gln Lys Phe Gln 
1               5                   10                  15      


Asp 
    


<210> 1766
<211> 51
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H2"

<400> 1766
tggatcctca ctcacaatgg ttacacaaac tatgcacaga agttccagga c                51


<210> 1767
<211> 16
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H3"

<400> 1767
Ala Arg Ile Gly His Val Thr Ala Val Ala Gly Ala Pro Pro Asp Tyr 
1               5                   10                  15      


<210> 1768
<211> 48
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H3"

<400> 1768
gcgagaattg gccatgttac agccgtggct ggtgcccctc ctgactac                    48


<210> 1769
<211> 330
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region"

<400> 1769
cagcctgtgc tgactcagcc tgcctccgtg tctgggtatc aaggacagtc gatcaccatc       60

tcctgcagtg gaaccagcag tgatgttggg acttataacc ttgtctcctg gtaccaacaa      120

cacccaggca aagcccccga actcatgatt tatgagggca gtaagcggcc ctcaggggtt      180

tctgatcgct tctctggctc caagtctggc aacacggcct ccctgacaat ctctgggctc      240

caggctgagg acgaggctga ttattactgc tgctcatatg tagctggtag tacttcagta      300

ttcggcggag ggaccaagct caccgtccta                                       330


<210> 1770
<211> 110
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region"

<400> 1770
Gln Pro Val Leu Thr Gln Pro Ala Ser Val Ser Gly Tyr Gln Gly Gln 
1               5                   10                  15      


Ser Ile Thr Ile Ser Cys Ser Gly Thr Ser Ser Asp Val Gly Thr Tyr 
            20                  25                  30          


Asn Leu Val Ser Trp Tyr Gln Gln His Pro Gly Lys Ala Pro Glu Leu 
        35                  40                  45              


Met Ile Tyr Glu Gly Ser Lys Arg Pro Ser Gly Val Ser Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Asn Thr Ala Ser Leu Thr Ile Ser Gly Leu 
65                  70                  75                  80  


Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Cys Ser Tyr Val Ala Gly 
                85                  90                  95      


Ser Thr Ser Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 110 


<210> 1771
<211> 14
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L1"

<400> 1771
Ser Gly Thr Ser Ser Asp Val Gly Thr Tyr Asn Leu Val Ser 
1               5                   10                  


<210> 1772
<211> 42
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L1"

<400> 1772
agtggaacca gcagtgatgt tgggacttat aaccttgtct cc                          42


<210> 1773
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L2"

<400> 1773
Glu Gly Ser Lys Arg Pro Ser 
1               5           


<210> 1774
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L2"

<400> 1774
gagggcagta agcggccctc a                                                 21


<210> 1775
<211> 10
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L3"

<400> 1775
Cys Ser Tyr Val Ala Gly Ser Thr Ser Val 
1               5                   10  


<210> 1776
<211> 30
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L3"

<400> 1776
tgctcatatg tagctggtag tacttcagta                                        30


<210> 1777
<211> 369
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region"

<400> 1777
gaggtgcagc tggtggagtc gggccctgga ctggtgaagc cttcagagac cctgtccctc       60

agttgcattg tctctggtgg ctccatcacc agtggtgatt actactggag ttggctccgc      120

cagtccccag ggaagggcct ggagtggatt gggtacatat atcacagcgg ggccaccttc      180

tacaccccgt ccctacggag tcgagtgacc atttcgacag acacctccaa gaaccaattc      240

tccctgagac tgtcgtctgt gaccgccgca gacacggccg tttattattg tgccagtgga      300

cctgtcggga tggctacaag caactggttc gacccctggg gccagggaac cctggtcacc      360

gtctcctca                                                              369


<210> 1778
<211> 123
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region"

<400> 1778
Glu Val Gln Leu Val Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Ser Cys Ile Val Ser Gly Gly Ser Ile Thr Ser Gly 
            20                  25                  30          


Asp Tyr Tyr Trp Ser Trp Leu Arg Gln Ser Pro Gly Lys Gly Leu Glu 
        35                  40                  45              


Trp Ile Gly Tyr Ile Tyr His Ser Gly Ala Thr Phe Tyr Thr Pro Ser 
    50                  55                  60                  


Leu Arg Ser Arg Val Thr Ile Ser Thr Asp Thr Ser Lys Asn Gln Phe 
65                  70                  75                  80  


Ser Leu Arg Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr 
                85                  90                  95      


Cys Ala Ser Gly Pro Val Gly Met Ala Thr Ser Asn Trp Phe Asp Pro 
            100                 105                 110         


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120             


<210> 1779
<211> 11
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H1"

<400> 1779
Gly Ser Ile Thr Ser Gly Asp Tyr Tyr Trp Ser 
1               5                   10      


<210> 1780
<211> 33
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H1"

<400> 1780
ggctccatca ccagtggtga ttactactgg agt                                    33


<210> 1781
<211> 16
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H2"

<400> 1781
Tyr Ile Tyr His Ser Gly Ala Thr Phe Tyr Thr Pro Ser Leu Arg Ser 
1               5                   10                  15      


<210> 1782
<211> 48
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H2"

<400> 1782
tacatatatc acagcggggc caccttctac accccgtccc tacggagt                    48


<210> 1783
<211> 15
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H3"

<400> 1783
Ala Ser Gly Pro Val Gly Met Ala Thr Ser Asn Trp Phe Asp Pro 
1               5                   10                  15  


<210> 1784
<211> 45
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H3"

<400> 1784
gccagtggac ctgtcgggat ggctacaagc aactggttcg acccc                       45


<210> 1785
<211> 327
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region"

<400> 1785
tcctatgagc tgacacagcc accctcagta tcagtcgccc cgggaaagac ggccaccatt       60

acgtgtgggg gagacatcat tagaactaac agtgtgaact ggtaccagca gaagccaggc      120

caggcccctc tattgctcat ctattatgat agcgaccggc cctcagggat ccctgagcga      180

ttctctgcct ccaactctgg gaacacggcc accctgacca tcagcagggt cgaggccggg      240

gatgaggccg actattactg tcaggtgtgg gacagtggta ctgattatca cgtggttttc      300

ggcggaggga ccaagctgac cgtccaa                                          327


<210> 1786
<211> 109
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region"

<400> 1786
Ser Tyr Glu Leu Thr Gln Pro Pro Ser Val Ser Val Ala Pro Gly Lys 
1               5                   10                  15      


Thr Ala Thr Ile Thr Cys Gly Gly Asp Ile Ile Arg Thr Asn Ser Val 
            20                  25                  30          


Asn Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Leu Leu Leu Ile Tyr 
        35                  40                  45              


Tyr Asp Ser Asp Arg Pro Ser Gly Ile Pro Glu Arg Phe Ser Ala Ser 
    50                  55                  60                  


Asn Ser Gly Asn Thr Ala Thr Leu Thr Ile Ser Arg Val Glu Ala Gly 
65                  70                  75                  80  


Asp Glu Ala Asp Tyr Tyr Cys Gln Val Trp Asp Ser Gly Thr Asp Tyr 
                85                  90                  95      


His Val Val Phe Gly Gly Gly Thr Lys Leu Thr Val Gln 
            100                 105                 


<210> 1787
<211> 11
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L1"

<400> 1787
Gly Gly Asp Ile Ile Arg Thr Asn Ser Val Asn 
1               5                   10      


<210> 1788
<211> 33
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L1"

<400> 1788
gggggagaca tcattagaac taacagtgtg aac                                    33


<210> 1789
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L2"

<400> 1789
Tyr Asp Ser Asp Arg Pro Ser 
1               5           


<210> 1790
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L2"

<400> 1790
tatgatagcg accggccctc a                                                 21


<210> 1791
<211> 12
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L3"

<400> 1791
Gln Val Trp Asp Ser Gly Thr Asp Tyr His Val Val 
1               5                   10          


<210> 1792
<211> 36
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L3"

<400> 1792
caggtgtggg acagtggtac tgattatcac gtggtt                                 36


<210> 1793
<211> 363
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region"

<400> 1793
caggtccagc tggtacagtc tggggctgag gtgaagaggc ctggggcctc agtgaaagtc       60

tcctgcaagg cttctgaata cgccttcacc gcccactatc ttcactgggt gcgacaggcc      120

cctgatcaag gacttgagtg gatgggatgg atcagcccta aaagtggtgg caccaactat      180

gcacagaagt ttcacggcag ggtcagcatg accagtgaca cgtccatcag tacagtctat      240

atggaactga gcagcctgac atctgacgac acggccgtct attactgtgc gagaagcagt      300

ctggtgggag caagccccaa ctttgacttc tggggccagg gaaccctggt caccgtctcc      360

tca                                                                    363


<210> 1794
<211> 121
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region"

<400> 1794
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Arg Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Glu Tyr Ala Phe Thr Ala His 
            20                  25                  30          


Tyr Leu His Trp Val Arg Gln Ala Pro Asp Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Ser Pro Lys Ser Gly Gly Thr Asn Tyr Ala Gln Lys Phe 
    50                  55                  60                  


His Gly Arg Val Ser Met Thr Ser Asp Thr Ser Ile Ser Thr Val Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Thr Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ser Ser Leu Val Gly Ala Ser Pro Asn Phe Asp Phe Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120     


<210> 1795
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H1"

<400> 1795
Tyr Ala Phe Thr Ala His Tyr Leu His 
1               5                   


<210> 1796
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H1"

<400> 1796
tacgccttca ccgcccacta tcttcac                                           27


<210> 1797
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H2"

<400> 1797
Trp Ile Ser Pro Lys Ser Gly Gly Thr Asn Tyr Ala Gln Lys Phe His 
1               5                   10                  15      


Gly 
    


<210> 1798
<211> 51
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H2"

<400> 1798
tggatcagcc ctaaaagtgg tggcaccaac tatgcacaga agtttcacgg c                51


<210> 1799
<211> 14
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H3"

<400> 1799
Ala Arg Ser Ser Leu Val Gly Ala Ser Pro Asn Phe Asp Phe 
1               5                   10                  


<210> 1800
<211> 42
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H3"

<400> 1800
gcgagaagca gtctggtggg agcaagcccc aactttgact tc                          42


<210> 1801
<211> 333
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region"

<400> 1801
cagtctgtgg tgacgcagcc gccctcagtg tctgcggccc caggacagag ggtcaccatc       60

tcctgctctg gaagcagctc caacattggg aataattatg tatcctggta ccagcaactc      120

ccaggatcta cccccaaagt cctcatttac gacaataatc agcgaccctc agggattcct      180

gaccgtttct ctggctccaa gtctggcacg tcagccaccc tggccatcag cggactccag      240

actggcgacg aggccgtcta ttattgcgga acatgggatg ccagcctgag tgctgcaatg      300

gttttcggcg gggggaccaa gctcaccgtc cta                                   333


<210> 1802
<211> 111
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region"

<400> 1802
Gln Ser Val Val Thr Gln Pro Pro Ser Val Ser Ala Ala Pro Gly Gln 
1               5                   10                  15      


Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn 
            20                  25                  30          


Tyr Val Ser Trp Tyr Gln Gln Leu Pro Gly Ser Thr Pro Lys Val Leu 
        35                  40                  45              


Ile Tyr Asp Asn Asn Gln Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Lys Ser Gly Thr Ser Ala Thr Leu Ala Ile Ser Gly Leu Gln 
65                  70                  75                  80  


Thr Gly Asp Glu Ala Val Tyr Tyr Cys Gly Thr Trp Asp Ala Ser Leu 
                85                  90                  95      


Ser Ala Ala Met Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 110     


<210> 1803
<211> 13
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L1"

<400> 1803
Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn Tyr Val Ser 
1               5                   10              


<210> 1804
<211> 39
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L1"

<400> 1804
tctggaagca gctccaacat tgggaataat tatgtatcc                              39


<210> 1805
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L2"

<400> 1805
Asp Asn Asn Gln Arg Pro Ser 
1               5           


<210> 1806
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L2"

<400> 1806
gacaataatc agcgaccctc a                                                 21


<210> 1807
<211> 12
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L3"

<400> 1807
Gly Thr Trp Asp Ala Ser Leu Ser Ala Ala Met Val 
1               5                   10          


<210> 1808
<211> 36
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L3"

<400> 1808
ggaacatggg atgccagcct gagtgctgca atggtt                                 36


<210> 1809
<211> 366
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region"

<400> 1809
caggtgcagc tacagcagtg gggcgcagga ctgttgaagc cttcggagac cctgtcccta       60

acctgcgctg tctctggtgg gtacttcatt aatgacaact ggagctggat ccgccagtcc      120

ccagggaagg ggctggagtg gattggagaa attagtcata gtggaagcac caactacaat      180

ccgtccctca agagtcgact caccatatca gttgacacgt ccaggcagca gttttccctg      240

aaattgagct ctgtgaccgc cgcggacagt ggtgtttact actgtgcgcg agtccacccg      300

tcgtatgact ttggctggcg cttctttgac ttctggggcc agggaaccct ggtcaccgtc      360

tcttca                                                                 366


<210> 1810
<211> 122
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region"

<400> 1810
Gln Val Gln Leu Gln Gln Trp Gly Ala Gly Leu Leu Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Ala Val Ser Gly Gly Tyr Phe Ile Asn Asp 
            20                  25                  30          


Asn Trp Ser Trp Ile Arg Gln Ser Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Glu Ile Ser His Ser Gly Ser Thr Asn Tyr Asn Pro Ser Leu Lys 
    50                  55                  60                  


Ser Arg Leu Thr Ile Ser Val Asp Thr Ser Arg Gln Gln Phe Ser Leu 
65                  70                  75                  80  


Lys Leu Ser Ser Val Thr Ala Ala Asp Ser Gly Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Val His Pro Ser Tyr Asp Phe Gly Trp Arg Phe Phe Asp Phe Trp 
            100                 105                 110         


Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120         


<210> 1811
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H1"

<400> 1811
Gly Tyr Phe Ile Asn Asp Asn Trp Ser 
1               5                   


<210> 1812
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H1"

<400> 1812
gggtacttca ttaatgacaa ctggagc                                           27


<210> 1813
<211> 16
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H2"

<400> 1813
Glu Ile Ser His Ser Gly Ser Thr Asn Tyr Asn Pro Ser Leu Lys Ser 
1               5                   10                  15      


<210> 1814
<211> 48
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H2"

<400> 1814
gaaattagtc atagtggaag caccaactac aatccgtccc tcaagagt                    48


<210> 1815
<211> 16
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H3"

<400> 1815
Ala Arg Val His Pro Ser Tyr Asp Phe Gly Trp Arg Phe Phe Asp Phe 
1               5                   10                  15      


<210> 1816
<211> 48
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H3"

<400> 1816
gcgcgagtcc acccgtcgta tgactttggc tggcgcttct ttgacttc                    48


<210> 1817
<211> 324
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region"

<400> 1817
gaaacgacac tcacgcagtc tccagccacc ctgtctgtgt ctccagggga tacagccacc       60

ctctcctgca gggccagtca gactattagt tccaacttag cctggtacca gcagaaacct      120

ggccagcctc ccagtctcct catctatgga gcatccaaca gggccactgg tatcccagac      180

aggtttcgtg gcagtgggtc tgggacagag ttcactctca ccatcagcag cctgcagtct      240

gaagattttg cagtttatta ctgtcagcag tatgcatact ggcctccgta cacttttggc      300

caggggacca aggtggagat caaa                                             324


<210> 1818
<211> 108
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region"

<400> 1818
Glu Thr Thr Leu Thr Gln Ser Pro Ala Thr Leu Ser Val Ser Pro Gly 
1               5                   10                  15      


Asp Thr Ala Thr Leu Ser Cys Arg Ala Ser Gln Thr Ile Ser Ser Asn 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro Ser Leu Leu Ile 
        35                  40                  45              


Tyr Gly Ala Ser Asn Arg Ala Thr Gly Ile Pro Asp Arg Phe Arg Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Ser 
65                  70                  75                  80  


Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Ala Tyr Trp Pro Pro 
                85                  90                  95      


Tyr Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105             


<210> 1819
<211> 11
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L1"

<400> 1819
Arg Ala Ser Gln Thr Ile Ser Ser Asn Leu Ala 
1               5                   10      


<210> 1820
<211> 33
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L1"

<400> 1820
agggccagtc agactattag ttccaactta gcc                                    33


<210> 1821
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L2"

<400> 1821
Gly Ala Ser Asn Arg Ala Thr 
1               5           


<210> 1822
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L2"

<400> 1822
ggagcatcca acagggccac t                                                 21


<210> 1823
<211> 10
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L3"

<400> 1823
Gln Gln Tyr Ala Tyr Trp Pro Pro Tyr Thr 
1               5                   10  


<210> 1824
<211> 30
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L3"

<400> 1824
cagcagtatg catactggcc tccgtacact                                        30


<210> 1825
<211> 369
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region"

<400> 1825
gaggtgcagc tgttggagtc gggcccagga ctggtgaagc cttcacagac cctgtccctc       60

acctgcactg tctcgggtgg ctccatcaac agtattgatt attattggag ctggatccgc      120

cagcccccag ggaagggcct ggagtggatt ggctacattt atcacagtgg gagcacccac      180

tacagaccat ccctcaagag tcgagtaacg atatcattag acaaggccaa gaacgagttc      240

tcgctgagtc tgacctctgt gactgccgca gacacggccg tgtatttctg tgccagtggc      300

cccgtcggga tggcaacaag caactggttc gacccctggg gccagggaac cctggtcacc      360

gtctcctca                                                              369


<210> 1826
<211> 123
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region"

<400> 1826
Glu Val Gln Leu Leu Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Gly Ser Ile Asn Ser Ile 
            20                  25                  30          


Asp Tyr Tyr Trp Ser Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu 
        35                  40                  45              


Trp Ile Gly Tyr Ile Tyr His Ser Gly Ser Thr His Tyr Arg Pro Ser 
    50                  55                  60                  


Leu Lys Ser Arg Val Thr Ile Ser Leu Asp Lys Ala Lys Asn Glu Phe 
65                  70                  75                  80  


Ser Leu Ser Leu Thr Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Phe 
                85                  90                  95      


Cys Ala Ser Gly Pro Val Gly Met Ala Thr Ser Asn Trp Phe Asp Pro 
            100                 105                 110         


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120             


<210> 1827
<211> 11
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H1"

<400> 1827
Gly Ser Ile Asn Ser Ile Asp Tyr Tyr Trp Ser 
1               5                   10      


<210> 1828
<211> 33
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H1"

<400> 1828
ggctccatca acagtattga ttattattgg agc                                    33


<210> 1829
<211> 16
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H2"

<400> 1829
Tyr Ile Tyr His Ser Gly Ser Thr His Tyr Arg Pro Ser Leu Lys Ser 
1               5                   10                  15      


<210> 1830
<211> 48
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H2"

<400> 1830
tacatttatc acagtgggag cacccactac agaccatccc tcaagagt                    48


<210> 1831
<211> 15
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H3"

<400> 1831
Ala Ser Gly Pro Val Gly Met Ala Thr Ser Asn Trp Phe Asp Pro 
1               5                   10                  15  


<210> 1832
<211> 45
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H3"

<400> 1832
gccagtggcc ccgtcgggat ggcaacaagc aactggttcg acccc                       45


<210> 1833
<211> 327
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region"

<400> 1833
cagcctgtgc tgactcagcc accctcagtg tcagtgaccc caggagagac ggccaggctt       60

ccctgtgagg gagacatcgt tgtcactaac agtgtccact ggtaccagca gaagccaggc      120

caggcccctg ttttggtcgt ctattatgat agcgaccggg cctcagggat ccctgagcga      180

ttctctggct ccaattctgg gaacacggcc accctgagca tcagcagggt cgaagccggg      240

gatgaggccg actactattg tcaggtgtgg gatagtagta ctgatcatca tgtggtgttc      300

ggcggtggga ccaagctcac cgtccta                                          327


<210> 1834
<211> 109
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region"

<400> 1834
Gln Pro Val Leu Thr Gln Pro Pro Ser Val Ser Val Thr Pro Gly Glu 
1               5                   10                  15      


Thr Ala Arg Leu Pro Cys Glu Gly Asp Ile Val Val Thr Asn Ser Val 
            20                  25                  30          


His Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Val Leu Val Val Tyr 
        35                  40                  45              


Tyr Asp Ser Asp Arg Ala Ser Gly Ile Pro Glu Arg Phe Ser Gly Ser 
    50                  55                  60                  


Asn Ser Gly Asn Thr Ala Thr Leu Ser Ile Ser Arg Val Glu Ala Gly 
65                  70                  75                  80  


Asp Glu Ala Asp Tyr Tyr Cys Gln Val Trp Asp Ser Ser Thr Asp His 
                85                  90                  95      


His Val Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 


<210> 1835
<211> 11
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L1"

<400> 1835
Glu Gly Asp Ile Val Val Thr Asn Ser Val His 
1               5                   10      


<210> 1836
<211> 33
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L1"

<400> 1836
gagggagaca tcgttgtcac taacagtgtc cac                                    33


<210> 1837
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L2"

<400> 1837
Tyr Asp Ser Asp Arg Ala Ser 
1               5           


<210> 1838
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L2"

<400> 1838
tatgatagcg accgggcctc a                                                 21


<210> 1839
<211> 12
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L3"

<400> 1839
Gln Val Trp Asp Ser Ser Thr Asp His His Val Val 
1               5                   10          


<210> 1840
<211> 36
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L3"

<400> 1840
caggtgtggg atagtagtac tgatcatcat gtggtg                                 36


<210> 1841
<211> 372
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region"

<400> 1841
caggtccagc tggtgcagtc tggggctgag gtgaagaagc ctgggtcctc ggtgaaggtc       60

tcctgcaagg cttctggagg cagattcagc agcgacgcta tcagctgggt gcgacaggcc      120

cctggacaag ggcttgagtg gatgggagga atcatcccta tccgtgggac accaacctac      180

gcacagaagt tccagggcag agtcacgatt atcgcggacg aatccacgac tacatcctac      240

atggagatga gcagcctgag atctgaggac acggccgtgt attactgtgc gagaccgaat      300

tacgatattt tgactggtta taatgatgct tttgatattt ggggccaagg gacaatggtc      360

accgtctctt ca                                                          372


<210> 1842
<211> 124
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region"

<400> 1842
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Arg Phe Ser Ser Asp 
            20                  25                  30          


Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Gly Ile Ile Pro Ile Arg Gly Thr Pro Thr Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Ile Ala Asp Glu Ser Thr Thr Thr Ser Tyr 
65                  70                  75                  80  


Met Glu Met Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Pro Asn Tyr Asp Ile Leu Thr Gly Tyr Asn Asp Ala Phe Asp 
            100                 105                 110         


Ile Trp Gly Gln Gly Thr Met Val Thr Val Ser Ser 
        115                 120                 


<210> 1843
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H1"

<400> 1843
Gly Arg Phe Ser Ser Asp Ala Ile Ser 
1               5                   


<210> 1844
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H1"

<400> 1844
ggcagattca gcagcgacgc tatcagc                                           27


<210> 1845
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H2"

<400> 1845
Gly Ile Ile Pro Ile Arg Gly Thr Pro Thr Tyr Ala Gln Lys Phe Gln 
1               5                   10                  15      


Gly 
    


<210> 1846
<211> 51
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H2"

<400> 1846
ggaatcatcc ctatccgtgg gacaccaacc tacgcacaga agttccaggg c                51


<210> 1847
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H3"

<400> 1847
Ala Arg Pro Asn Tyr Asp Ile Leu Thr Gly Tyr Asn Asp Ala Phe Asp 
1               5                   10                  15      


Ile 
    


<210> 1848
<211> 51
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H3"

<400> 1848
gcgagaccga attacgatat tttgactggt tataatgatg cttttgatat t                51


<210> 1849
<211> 327
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region"

<400> 1849
cagtctgtgt tgacgcagcc tcgctcagtg tccgggtctc ctggacagtc agtcaccatc       60

tcctgcactg gaaccagcag tgatgttggt ggttataact atgtctcctg gtaccaacag      120

cacccaggca aagtccccag actcatgatt tacgatgtca gtaagcggcc ctcaggggcc      180

cctgatcgct tctctggctc caagtctggc aacacggcct ccctgaccat ctctgggctc      240

caggctgagg atgaggctga ttattactgc tgctcatatg caggcggcct ttatgtcttc      300

ggaactggga ccaagctcac cgtccta                                          327


<210> 1850
<211> 109
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region"

<400> 1850
Gln Ser Val Leu Thr Gln Pro Arg Ser Val Ser Gly Ser Pro Gly Gln 
1               5                   10                  15      


Ser Val Thr Ile Ser Cys Thr Gly Thr Ser Ser Asp Val Gly Gly Tyr 
            20                  25                  30          


Asn Tyr Val Ser Trp Tyr Gln Gln His Pro Gly Lys Val Pro Arg Leu 
        35                  40                  45              


Met Ile Tyr Asp Val Ser Lys Arg Pro Ser Gly Ala Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Asn Thr Ala Ser Leu Thr Ile Ser Gly Leu 
65                  70                  75                  80  


Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Cys Ser Tyr Ala Gly Gly 
                85                  90                  95      


Leu Tyr Val Phe Gly Thr Gly Thr Lys Leu Thr Val Leu 
            100                 105                 


<210> 1851
<211> 14
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L1"

<400> 1851
Thr Gly Thr Ser Ser Asp Val Gly Gly Tyr Asn Tyr Val Ser 
1               5                   10                  


<210> 1852
<211> 42
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L1"

<400> 1852
actggaacca gcagtgatgt tggtggttat aactatgtct cc                          42


<210> 1853
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L2"

<400> 1853
Asp Val Ser Lys Arg Pro Ser 
1               5           


<210> 1854
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L2"

<400> 1854
gatgtcagta agcggccctc a                                                 21


<210> 1855
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L3"

<400> 1855
Cys Ser Tyr Ala Gly Gly Leu Tyr Val 
1               5                   


<210> 1856
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L3"

<400> 1856
tgctcatatg caggcggcct ttatgtc                                           27


<210> 1857
<211> 378
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region"

<400> 1857
gaggtgcagc tggtggagtc cggggctgag gtgaagaagc ctggggcctc agtgaaggtc       60

tcctgcaagg cttctggata caccttcacc acttatgata tcaactgggt gcgacaggcc      120

actggacggg ggcttgagtg gatgggatgg atgacccctg atagtggtag cacaggctat      180

ccacagaact tccagggcag agtcaccatg accaggaaca cctccataag cacagcctac      240

atggagttga gcaacctgag atctgaggac acggccgtat attactgtgt gcaaatggac      300

cattgtagaa gtaccagctg ctctgagggg aactggttcg acacctgggg ccagggaacc      360

ctggtcaccg tctcctca                                                    378


<210> 1858
<211> 126
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region"

<400> 1858
Glu Val Gln Leu Val Glu Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Thr Tyr 
            20                  25                  30          


Asp Ile Asn Trp Val Arg Gln Ala Thr Gly Arg Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Met Thr Pro Asp Ser Gly Ser Thr Gly Tyr Pro Gln Asn Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Met Thr Arg Asn Thr Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Asn Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Val Gln Met Asp His Cys Arg Ser Thr Ser Cys Ser Glu Gly Asn Trp 
            100                 105                 110         


Phe Asp Thr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125     


<210> 1859
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H1"

<400> 1859
Tyr Thr Phe Thr Thr Tyr Asp Ile Asn 
1               5                   


<210> 1860
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H1"

<400> 1860
tacaccttca ccacttatga tatcaac                                           27


<210> 1861
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H2"

<400> 1861
Trp Met Thr Pro Asp Ser Gly Ser Thr Gly Tyr Pro Gln Asn Phe Gln 
1               5                   10                  15      


Gly 
    


<210> 1862
<211> 51
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H2"

<400> 1862
tggatgaccc ctgatagtgg tagcacaggc tatccacaga acttccaggg c                51


<210> 1863
<211> 19
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H3"

<400> 1863
Val Gln Met Asp His Cys Arg Ser Thr Ser Cys Ser Glu Gly Asn Trp 
1               5                   10                  15      


Phe Asp Thr 
            


<210> 1864
<211> 57
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H3"

<400> 1864
gtgcaaatgg accattgtag aagtaccagc tgctctgagg ggaactggtt cgacacc          57


<210> 1865
<211> 330
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region"

<400> 1865
cagcctgggc tgactcagcc accctcggtg tctgcagccc ccaggcagag ggtcaccatc       60

tcctgttctg gaagcagctc caacatcgga actaatgctg taaactggta ccagcagctc      120

ccaggaaagg ctcccaaact cctcatctat tctgataatc tgatgccctc aggggtctct      180

gcccgattct ctggctccaa gtctggcacc tcggcctccc tggccatcag tgggctccag      240

tctgaggatg aggctgatta ttactgtgca gcatgggatg acagcctgaa tgtttgggtg      300

ttcggcgggg ggaccaagct caccgtccta                                       330


<210> 1866
<211> 110
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region"

<400> 1866
Gln Pro Gly Leu Thr Gln Pro Pro Ser Val Ser Ala Ala Pro Arg Gln 
1               5                   10                  15      


Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Thr Asn 
            20                  25                  30          


Ala Val Asn Trp Tyr Gln Gln Leu Pro Gly Lys Ala Pro Lys Leu Leu 
        35                  40                  45              


Ile Tyr Ser Asp Asn Leu Met Pro Ser Gly Val Ser Ala Arg Phe Ser 
    50                  55                  60                  


Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Gln 
65                  70                  75                  80  


Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Asp Ser Leu 
                85                  90                  95      


Asn Val Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 110 


<210> 1867
<211> 13
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L1"

<400> 1867
Ser Gly Ser Ser Ser Asn Ile Gly Thr Asn Ala Val Asn 
1               5                   10              


<210> 1868
<211> 39
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L1"

<400> 1868
tctggaagca gctccaacat cggaactaat gctgtaaac                              39


<210> 1869
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L2"

<400> 1869
Ser Asp Asn Leu Met Pro Ser 
1               5           


<210> 1870
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L2"

<400> 1870
tctgataatc tgatgccctc a                                                 21


<210> 1871
<211> 11
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L3"

<400> 1871
Ala Ala Trp Asp Asp Ser Leu Asn Val Trp Val 
1               5                   10      


<210> 1872
<211> 33
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L3"

<400> 1872
gcagcatggg atgacagcct gaatgtttgg gtg                                    33


<210> 1873
<211> 375
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region"

<400> 1873
gaggtgcagc tggtggagtc tgggggaggc ttggtgaagc cagggcggtc cctgagactc       60

tcctgtacag cctctggatt caacttcggt gattatgcta tgagctggtt ccgccaggct      120

ccagggaagg ggctggagtg ggtaggtttc attagaagca aaacttatcg tgagacaaga      180

gaatacgccg cgtctgtgaa aggcagattc accatgtcaa gagatgattt caacaggatc      240

gcctatctgc aaatgaacag cctgaaaacc gaggacacag ccatgtatta ttgtacgaga      300

caagacgatt tttggagtgg tcatccctac tactttgagt actggggcca gggaaccctg      360

gtcaccgtct cctca                                                       375


<210> 1874
<211> 125
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region"

<400> 1874
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Thr Ala Ser Gly Phe Asn Phe Gly Asp Tyr 
            20                  25                  30          


Ala Met Ser Trp Phe Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Gly Phe Ile Arg Ser Lys Thr Tyr Arg Glu Thr Arg Glu Tyr Ala Ala 
    50                  55                  60                  


Ser Val Lys Gly Arg Phe Thr Met Ser Arg Asp Asp Phe Asn Arg Ile 
65                  70                  75                  80  


Ala Tyr Leu Gln Met Asn Ser Leu Lys Thr Glu Asp Thr Ala Met Tyr 
                85                  90                  95      


Tyr Cys Thr Arg Gln Asp Asp Phe Trp Ser Gly His Pro Tyr Tyr Phe 
            100                 105                 110         


Glu Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125 


<210> 1875
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H1"

<400> 1875
Phe Asn Phe Gly Asp Tyr Ala Met Ser 
1               5                   


<210> 1876
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H1"

<400> 1876
ttcaacttcg gtgattatgc tatgagc                                           27


<210> 1877
<211> 19
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H2"

<400> 1877
Phe Ile Arg Ser Lys Thr Tyr Arg Glu Thr Arg Glu Tyr Ala Ala Ser 
1               5                   10                  15      


Val Lys Gly 
            


<210> 1878
<211> 57
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H2"

<400> 1878
ttcattagaa gcaaaactta tcgtgagaca agagaatacg ccgcgtctgt gaaaggc          57


<210> 1879
<211> 16
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H3"

<400> 1879
Thr Arg Gln Asp Asp Phe Trp Ser Gly His Pro Tyr Tyr Phe Glu Tyr 
1               5                   10                  15      


<210> 1880
<211> 48
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H3"

<400> 1880
acgagacaag acgatttttg gagtggtcat ccctactact ttgagtac                    48


<210> 1881
<211> 333
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region"

<400> 1881
cagcctgtgc tgactcagcc cccctccgcg tccgggtctc ctggacagtc agtcaccatc       60

tcctgcactg gaaccaacag tgacgtgggt agttataact atgtctcctg gtaccaacat      120

cacccaggca aagcccccaa actcatcatt tatgacgtcg ctaagcggcc ctcaggggtc      180

cctgatcgct tctctggctc caagtctggc aacacggcct ccctgaccgt ctctgggctc      240

caggctgagg atgaggctga ttattactgc agctcatatg caggcagtaa cgatttgggg      300

gtcttcggaa ctgggaccaa gctcaccgtc cta                                   333


<210> 1882
<211> 111
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region"

<400> 1882
Gln Pro Val Leu Thr Gln Pro Pro Ser Ala Ser Gly Ser Pro Gly Gln 
1               5                   10                  15      


Ser Val Thr Ile Ser Cys Thr Gly Thr Asn Ser Asp Val Gly Ser Tyr 
            20                  25                  30          


Asn Tyr Val Ser Trp Tyr Gln His His Pro Gly Lys Ala Pro Lys Leu 
        35                  40                  45              


Ile Ile Tyr Asp Val Ala Lys Arg Pro Ser Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Asn Thr Ala Ser Leu Thr Val Ser Gly Leu 
65                  70                  75                  80  


Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Ser Ser Tyr Ala Gly Ser 
                85                  90                  95      


Asn Asp Leu Gly Val Phe Gly Thr Gly Thr Lys Leu Thr Val Leu 
            100                 105                 110     


<210> 1883
<211> 14
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L1"

<400> 1883
Thr Gly Thr Asn Ser Asp Val Gly Ser Tyr Asn Tyr Val Ser 
1               5                   10                  


<210> 1884
<211> 42
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L1"

<400> 1884
actggaacca acagtgacgt gggtagttat aactatgtct cc                          42


<210> 1885
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L2"

<400> 1885
Asp Val Ala Lys Arg Pro Ser 
1               5           


<210> 1886
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L2"

<400> 1886
gacgtcgcta agcggccctc a                                                 21


<210> 1887
<211> 11
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L3"

<400> 1887
Ser Ser Tyr Ala Gly Ser Asn Asp Leu Gly Val 
1               5                   10      


<210> 1888
<211> 33
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L3"

<400> 1888
agctcatatg caggcagtaa cgatttgggg gtc                                    33


<210> 1889
<211> 372
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region"

<400> 1889
gaggtgcagc tggtggagtc cggcccagga ctggtgaagc cttcggagac cctgtccctc       60

acctgcactg tgtctggtgg ctccgtcagt ggtcactact ggagctggat tcggcagttc      120

ccagggaagg aactggaatg gattggtcat atctattata ttgggacgac caactacaac      180

ccctccctca agagtcgagt catcatatcg ctagacacgt ccaagaatca gctctccctg      240

aagctgagtt ctgtgaccgc tgcggacact gccgtttatt attgtgccag acagttcggc      300

tatgataaaa atactttaag tcggcttgac tttgactact ggggccaggg aaccctggtc      360

accgtctcct ca                                                          372


<210> 1890
<211> 124
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region"

<400> 1890
Glu Val Gln Leu Val Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Gly Ser Val Ser Gly His 
            20                  25                  30          


Tyr Trp Ser Trp Ile Arg Gln Phe Pro Gly Lys Glu Leu Glu Trp Ile 
        35                  40                  45              


Gly His Ile Tyr Tyr Ile Gly Thr Thr Asn Tyr Asn Pro Ser Leu Lys 
    50                  55                  60                  


Ser Arg Val Ile Ile Ser Leu Asp Thr Ser Lys Asn Gln Leu Ser Leu 
65                  70                  75                  80  


Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Gln Phe Gly Tyr Asp Lys Asn Thr Leu Ser Arg Leu Asp Phe Asp 
            100                 105                 110         


Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 


<210> 1891
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H1"

<400> 1891
Gly Ser Val Ser Gly His Tyr Trp Ser 
1               5                   


<210> 1892
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H1"

<400> 1892
ggctccgtca gtggtcacta ctggagc                                           27


<210> 1893
<211> 16
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H2"

<400> 1893
His Ile Tyr Tyr Ile Gly Thr Thr Asn Tyr Asn Pro Ser Leu Lys Ser 
1               5                   10                  15      


<210> 1894
<211> 48
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H2"

<400> 1894
catatctatt atattgggac gaccaactac aacccctccc tcaagagt                    48


<210> 1895
<211> 18
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H3"

<400> 1895
Ala Arg Gln Phe Gly Tyr Asp Lys Asn Thr Leu Ser Arg Leu Asp Phe 
1               5                   10                  15      


Asp Tyr 
        


<210> 1896
<211> 54
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H3"

<400> 1896
gccagacagt tcggctatga taaaaatact ttaagtcggc ttgactttga ctac             54


<210> 1897
<211> 321
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region"

<400> 1897
gacatccaga tgacccagtc tccatcctcc ctgtctgcat ctgtaagaga cagagtcacc       60

atcacttgcc gggcaagtca gagcattagc agctatttaa attggtatca acagagacca      120

gggaaagccc ctaagctcct gatctattct gcattcagtt tacatagtgg tgtcccatca      180

aggttcagtg gcagtggatc tgagacagag ttcactctca ccatcagcag tctgcaacct      240

gacgattttg caacttatta ctgtcaacag agttacagta ttccctggac gttcggccaa      300

gggaccaagg tggaaatcaa a                                                321


<210> 1898
<211> 107
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region"

<400> 1898
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Arg 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Arg Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ser Ala Phe Ser Leu His Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Glu Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Asp Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Tyr Ser Ile Pro Trp 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210> 1899
<211> 11
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L1"

<400> 1899
Arg Ala Ser Gln Ser Ile Ser Ser Tyr Leu Asn 
1               5                   10      


<210> 1900
<211> 33
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L1"

<400> 1900
cgggcaagtc agagcattag cagctattta aat                                    33


<210> 1901
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L2"

<400> 1901
Ser Ala Phe Ser Leu His Ser 
1               5           


<210> 1902
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L2"

<400> 1902
tctgcattca gtttacatag t                                                 21


<210> 1903
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L3"

<400> 1903
Gln Gln Ser Tyr Ser Ile Pro Trp Thr 
1               5                   


<210> 1904
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L3"

<400> 1904
caacagagtt acagtattcc ctggacg                                           27


<210> 1905
<211> 369
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region"

<400> 1905
caggtgcagc tgcaggagtc cggcccggga ctggtgaagc cttcggagac cctgtccctc       60

acctgcagtg tctctggtgg ctccatcacc aatgttaatt actactgggg ctggatccgc      120

cagccccccg ggaagggcct ggagtggatt gggagtatct attataatgg aaacacctac      180

tacaacccgt ccctccagag tcgagtcacc atgtccgtgg acacgtccaa gaaccacttc      240

tccctgaggc tgacgtctgt gaccgccgca gacacggctg tatatttttg tgcgagagag      300

gggcctaatt gggaattgtt gaatgctttc gatatctggg gccaagggac cacggtcacc      360

gtctcctca                                                              369


<210> 1906
<211> 123
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region"

<400> 1906
Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Ser Val Ser Gly Gly Ser Ile Thr Asn Val 
            20                  25                  30          


Asn Tyr Tyr Trp Gly Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu 
        35                  40                  45              


Trp Ile Gly Ser Ile Tyr Tyr Asn Gly Asn Thr Tyr Tyr Asn Pro Ser 
    50                  55                  60                  


Leu Gln Ser Arg Val Thr Met Ser Val Asp Thr Ser Lys Asn His Phe 
65                  70                  75                  80  


Ser Leu Arg Leu Thr Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Phe 
                85                  90                  95      


Cys Ala Arg Glu Gly Pro Asn Trp Glu Leu Leu Asn Ala Phe Asp Ile 
            100                 105                 110         


Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120             


<210> 1907
<211> 11
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H1"

<400> 1907
Gly Ser Ile Thr Asn Val Asn Tyr Tyr Trp Gly 
1               5                   10      


<210> 1908
<211> 33
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H1"

<400> 1908
ggctccatca ccaatgttaa ttactactgg ggc                                    33


<210> 1909
<211> 16
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H2"

<400> 1909
Ser Ile Tyr Tyr Asn Gly Asn Thr Tyr Tyr Asn Pro Ser Leu Gln Ser 
1               5                   10                  15      


<210> 1910
<211> 48
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H2"

<400> 1910
agtatctatt ataatggaaa cacctactac aacccgtccc tccagagt                    48


<210> 1911
<211> 15
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H3"

<400> 1911
Ala Arg Glu Gly Pro Asn Trp Glu Leu Leu Asn Ala Phe Asp Ile 
1               5                   10                  15  


<210> 1912
<211> 45
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H3"

<400> 1912
gcgagagagg ggcctaattg ggaattgttg aatgctttcg atatc                       45


<210> 1913
<211> 324
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region"

<400> 1913
tcctatgagc tgactcagcc accctcggtg tcagtggccc caggacagac ggccaggatt       60

acctgtgggg gaaacaacat tggaagtaaa aatgtgcact ggtaccagca gaagccaggc      120

caggcccctg tcttggtcgt ctatgaggat acccaccggc cctcagggat ccctgagcga      180

ttctctggct ccaactctgg gaacacggcc accctgacca tcagtagggt cgaagccggg      240

gatgaggccg actattactg tcaggtgtgg gatactagta gtgatcatgt ggtattcggc      300

ggagggacca agctgaccgt cctc                                             324


<210> 1914
<211> 108
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region"

<400> 1914
Ser Tyr Glu Leu Thr Gln Pro Pro Ser Val Ser Val Ala Pro Gly Gln 
1               5                   10                  15      


Thr Ala Arg Ile Thr Cys Gly Gly Asn Asn Ile Gly Ser Lys Asn Val 
            20                  25                  30          


His Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Val Leu Val Val Tyr 
        35                  40                  45              


Glu Asp Thr His Arg Pro Ser Gly Ile Pro Glu Arg Phe Ser Gly Ser 
    50                  55                  60                  


Asn Ser Gly Asn Thr Ala Thr Leu Thr Ile Ser Arg Val Glu Ala Gly 
65                  70                  75                  80  


Asp Glu Ala Asp Tyr Tyr Cys Gln Val Trp Asp Thr Ser Ser Asp His 
                85                  90                  95      


Val Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105             


<210> 1915
<211> 11
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L1"

<400> 1915
Gly Gly Asn Asn Ile Gly Ser Lys Asn Val His 
1               5                   10      


<210> 1916
<211> 33
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L1"

<400> 1916
gggggaaaca acattggaag taaaaatgtg cac                                    33


<210> 1917
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L2"

<400> 1917
Glu Asp Thr His Arg Pro Ser 
1               5           


<210> 1918
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L2"

<400> 1918
gaggataccc accggccctc a                                                 21


<210> 1919
<211> 11
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L3"

<400> 1919
Gln Val Trp Asp Thr Ser Ser Asp His Val Val 
1               5                   10      


<210> 1920
<211> 33
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L3"

<400> 1920
caggtgtggg atactagtag tgatcatgtg gta                                    33


<210> 1921
<211> 363
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region"

<400> 1921
caggtccagc ttgtgcagtc tggggctgag gtgaagaagc ctggggcctc agtgaaggtc       60

tcctgcaaga cttctggtta cacctttagt catttcggtg tcacctggat acgacaggcc      120

ccaggacaag ggcttgagtg gctgggatgg atcagcgctt acaatggtaa cacagactct      180

gcagacaaac tgcagggcag actcaccatg acgacagaca catccacgaa caccgcctac      240

atggagttga ggagcctcag atctgacgac acggccgtct attactgtgc gagagatccc      300

cccgcatcag ctgctgccat gcttgactac tggggccagg gaaccctggt caccgtctcc      360

tca                                                                    363


<210> 1922
<211> 121
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region"

<400> 1922
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Thr Ser Gly Tyr Thr Phe Ser His Phe 
            20                  25                  30          


Gly Val Thr Trp Ile Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Leu 
        35                  40                  45              


Gly Trp Ile Ser Ala Tyr Asn Gly Asn Thr Asp Ser Ala Asp Lys Leu 
    50                  55                  60                  


Gln Gly Arg Leu Thr Met Thr Thr Asp Thr Ser Thr Asn Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Arg Ser Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Pro Pro Ala Ser Ala Ala Ala Met Leu Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120     


<210> 1923
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H1"

<400> 1923
Tyr Thr Phe Ser His Phe Gly Val Thr 
1               5                   


<210> 1924
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H1"

<400> 1924
tacaccttta gtcatttcgg tgtcacc                                           27


<210> 1925
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H2"

<400> 1925
Trp Ile Ser Ala Tyr Asn Gly Asn Thr Asp Ser Ala Asp Lys Leu Gln 
1               5                   10                  15      


Gly 
    


<210> 1926
<211> 51
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H2"

<400> 1926
tggatcagcg cttacaatgg taacacagac tctgcagaca aactgcaggg c                51


<210> 1927
<211> 14
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H3"

<400> 1927
Ala Arg Asp Pro Pro Ala Ser Ala Ala Ala Met Leu Asp Tyr 
1               5                   10                  


<210> 1928
<211> 42
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H3"

<400> 1928
gcgagagatc cccccgcatc agctgctgcc atgcttgact ac                          42


<210> 1929
<211> 339
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region"

<400> 1929
gacatccaga tgacccagtc tccactctcc ctggccgtca cccttggaca gccggcctcc       60

atctcctgca ggtctagtca aggcctcgaa tacactgatg gaaacaccta cttgagttgg      120

tttcagcaga ggccaggcca atctccaagg cgcctcattt ataaggtttc taatcgggac      180

tctggggtcc cagacagatt cagcggcagc ggggcaggca ctgatttcac actgagaatc      240

agcagggtgg aggctgagga tgttggggtt tattactgca tgcaaggtac acacgggcgg      300

ggaatctctt tcggtcctgg gaccaaagtg gatatcaaa                             339


<210> 1930
<211> 113
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region"

<400> 1930
Asp Ile Gln Met Thr Gln Ser Pro Leu Ser Leu Ala Val Thr Leu Gly 
1               5                   10                  15      


Gln Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Gly Leu Glu Tyr Thr 
            20                  25                  30          


Asp Gly Asn Thr Tyr Leu Ser Trp Phe Gln Gln Arg Pro Gly Gln Ser 
        35                  40                  45              


Pro Arg Arg Leu Ile Tyr Lys Val Ser Asn Arg Asp Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ala Gly Thr Asp Phe Thr Leu Arg Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Met Gln Gly 
                85                  90                  95      


Thr His Gly Arg Gly Ile Ser Phe Gly Pro Gly Thr Lys Val Asp Ile 
            100                 105                 110         


Lys 
    


<210> 1931
<211> 16
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L1"

<400> 1931
Arg Ser Ser Gln Gly Leu Glu Tyr Thr Asp Gly Asn Thr Tyr Leu Ser 
1               5                   10                  15      


<210> 1932
<211> 48
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L1"

<400> 1932
aggtctagtc aaggcctcga atacactgat ggaaacacct acttgagt                    48


<210> 1933
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L2"

<400> 1933
Lys Val Ser Asn Arg Asp Ser 
1               5           


<210> 1934
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L2"

<400> 1934
aaggtttcta atcgggactc t                                                 21


<210> 1935
<211> 10
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L3"

<400> 1935
Met Gln Gly Thr His Gly Arg Gly Ile Ser 
1               5                   10  


<210> 1936
<211> 30
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L3"

<400> 1936
atgcaaggta cacacgggcg gggaatctct                                        30


<210> 1937
<211> 363
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region"

<400> 1937
caggtgcagc tggtgcagtc tggggctgag gtgaagaagc ctggggcctc agtgagggtc       60

tcctgcaagg cctctggata caccttcacc gactacttta tgaactgggt gcgacaggcc      120

cctggagggg gccttgagtg gatggggtgg atcaatcctc tcagtggagt cacaaaatat      180

gcacagcagt ttcagggcag tgtcaccatg accactgaca cgtccatcac cacaggctac      240

atggagctga ggagcctgag agttgacgac acggccgtct attattgtgc gagccagtct      300

tccccttaca ccccgggcgc catgggcgtc tggggccaag ggaccacggt caccgtctcc      360

tca                                                                    363


<210> 1938
<211> 121
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region"

<400> 1938
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Arg Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Tyr 
            20                  25                  30          


Phe Met Asn Trp Val Arg Gln Ala Pro Gly Gly Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Asn Pro Leu Ser Gly Val Thr Lys Tyr Ala Gln Gln Phe 
    50                  55                  60                  


Gln Gly Ser Val Thr Met Thr Thr Asp Thr Ser Ile Thr Thr Gly Tyr 
65                  70                  75                  80  


Met Glu Leu Arg Ser Leu Arg Val Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ser Gln Ser Ser Pro Tyr Thr Pro Gly Ala Met Gly Val Trp Gly 
            100                 105                 110         


Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120     


<210> 1939
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H1"

<400> 1939
Tyr Thr Phe Thr Asp Tyr Phe Met Asn 
1               5                   


<210> 1940
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H1"

<400> 1940
tacaccttca ccgactactt tatgaac                                           27


<210> 1941
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H2"

<400> 1941
Trp Ile Asn Pro Leu Ser Gly Val Thr Lys Tyr Ala Gln Gln Phe Gln 
1               5                   10                  15      


Gly 
    


<210> 1942
<211> 51
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H2"

<400> 1942
tggatcaatc ctctcagtgg agtcacaaaa tatgcacagc agtttcaggg c                51


<210> 1943
<211> 14
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H3"

<400> 1943
Ala Ser Gln Ser Ser Pro Tyr Thr Pro Gly Ala Met Gly Val 
1               5                   10                  


<210> 1944
<211> 42
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H3"

<400> 1944
gcgagccagt cttcccctta caccccgggc gccatgggcg tc                          42


<210> 1945
<211> 321
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region"

<400> 1945
gacatccgga tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga cagagtcacc       60

atcacttgcc ggacaagtca gagcgttagc ggctatttaa gttggtatca gcagaaacca      120

gggaaagccc ctaagctcct gatctatgcg gcatccaatt tgtacagtgg ggtcccatca      180

aggttcagtg gcagtggatc tgggacagat ttcactctca ccatcaccag tctgcaacct      240

gaagattttg caacttactt ctgtcaactg aattccggtg ccctattcac tttcggccct      300

gggaccaagg tggaaatcaa a                                                321


<210> 1946
<211> 107
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region"

<400> 1946
Asp Ile Arg Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Thr Ser Gln Ser Val Ser Gly Tyr 
            20                  25                  30          


Leu Ser Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Asn Leu Tyr Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Thr Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Phe Cys Gln Leu Asn Ser Gly Ala Leu Phe 
                85                  90                  95      


Thr Phe Gly Pro Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210> 1947
<211> 11
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L1"

<400> 1947
Arg Thr Ser Gln Ser Val Ser Gly Tyr Leu Ser 
1               5                   10      


<210> 1948
<211> 33
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L1"

<400> 1948
cggacaagtc agagcgttag cggctattta agt                                    33


<210> 1949
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L2"

<400> 1949
Ala Ala Ser Asn Leu Tyr Ser 
1               5           


<210> 1950
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L2"

<400> 1950
gcggcatcca atttgtacag t                                                 21


<210> 1951
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L3"

<400> 1951
Gln Leu Asn Ser Gly Ala Leu Phe Thr 
1               5                   


<210> 1952
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L3"

<400> 1952
caactgaatt ccggtgccct attcact                                           27


<210> 1953
<211> 363
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region"

<400> 1953
gaggtgcagc tggtggagtc tgggggaggc ttggtcaagc ctggagagtc cgtgaaactc       60

tcctgcgcag cgtctggatt caccatcact gactcctaca tggcctggat ccgccagtct      120

ccagggaagg ggctggagtg gcttgcttac attagtagta ctagtctttt cacagactac      180

acagactctg tgaagggccg attcatcatc accagagaca atgccgagaa ctcactctat      240

ctgcaaatga ccagcctgac accggcagac acgggtgtct atttctgtgc gagggccaaa      300

acatcctact acttctacgc tctggacgtc tggggcccag gcaccctggt caccgtctcc      360

tca                                                                    363


<210> 1954
<211> 121
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region"

<400> 1954
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Glu 
1               5                   10                  15      


Ser Val Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Ile Thr Asp Ser 
            20                  25                  30          


Tyr Met Ala Trp Ile Arg Gln Ser Pro Gly Lys Gly Leu Glu Trp Leu 
        35                  40                  45              


Ala Tyr Ile Ser Ser Thr Ser Leu Phe Thr Asp Tyr Thr Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Ile Ile Thr Arg Asp Asn Ala Glu Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Thr Ser Leu Thr Pro Ala Asp Thr Gly Val Tyr Phe Cys 
                85                  90                  95      


Ala Arg Ala Lys Thr Ser Tyr Tyr Phe Tyr Ala Leu Asp Val Trp Gly 
            100                 105                 110         


Pro Gly Thr Leu Val Thr Val Ser Ser 
        115                 120     


<210> 1955
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H1"

<400> 1955
Phe Thr Ile Thr Asp Ser Tyr Met Ala 
1               5                   


<210> 1956
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H1"

<400> 1956
ttcaccatca ctgactccta catggcc                                           27


<210> 1957
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H2"

<400> 1957
Tyr Ile Ser Ser Thr Ser Leu Phe Thr Asp Tyr Thr Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210> 1958
<211> 51
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H2"

<400> 1958
tacattagta gtactagtct tttcacagac tacacagact ctgtgaaggg c                51


<210> 1959
<211> 14
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H3"

<400> 1959
Ala Arg Ala Lys Thr Ser Tyr Tyr Phe Tyr Ala Leu Asp Val 
1               5                   10                  


<210> 1960
<211> 42
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H3"

<400> 1960
gcgagggcca aaacatccta ctacttctac gctctggacg tc                          42


<210> 1961
<211> 321
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region"

<400> 1961
gaaacgacac tcacgcagtc tccaggcacg ctgtctttgt ctccggggga aagagccacc       60

ctctcctgca gggccagtca gagtgttaac aacaactatc tagcctggtt ccagcacaaa      120

cctggccagg ctcccagact cctcatctat aatgcatcca acagggccgc tggcatccca      180

gacaggttca gtggtagtgg gtctgggaca gacttcactc tcaccatcag caaactggag      240

cctggagatt ctgcagtgta ttactgtcag cgatatggga actcttggcc gttcggccaa      300

gggaccaagg tggaaatcaa a                                                321


<210> 1962
<211> 107
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region"

<400> 1962
Glu Thr Thr Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Asn Asn Asn 
            20                  25                  30          


Tyr Leu Ala Trp Phe Gln His Lys Pro Gly Gln Ala Pro Arg Leu Leu 
        35                  40                  45              


Ile Tyr Asn Ala Ser Asn Arg Ala Ala Gly Ile Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Lys Leu Glu 
65                  70                  75                  80  


Pro Gly Asp Ser Ala Val Tyr Tyr Cys Gln Arg Tyr Gly Asn Ser Trp 
                85                  90                  95      


Pro Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210> 1963
<211> 12
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L1"

<400> 1963
Arg Ala Ser Gln Ser Val Asn Asn Asn Tyr Leu Ala 
1               5                   10          


<210> 1964
<211> 36
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L1"

<400> 1964
agggccagtc agagtgttaa caacaactat ctagcc                                 36


<210> 1965
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L2"

<400> 1965
Asn Ala Ser Asn Arg Ala Ala 
1               5           


<210> 1966
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L2"

<400> 1966
aatgcatcca acagggccgc t                                                 21


<210> 1967
<211> 8
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L3"

<400> 1967
Gln Arg Tyr Gly Asn Ser Trp Pro 
1               5               


<210> 1968
<211> 24
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L3"

<400> 1968
cagcgatatg ggaactcttg gccg                                              24


<210> 1969
<211> 372
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region"

<400> 1969
caggtccagc tggtgcagtc tgggggaggc ttggtacagc ctggggggtc cctgagactc       60

tcctgtgcag cctctggatt cacctttagt cagtctccca tgagctgggt ccgccaggct      120

cctgggaagg ggctggagtg ggtctccggt attagtactg gagggaccaa tacatactac      180

gcagactccg tgaagggccg cttcaccatc tccagagaca attccaagaa cacgttgtat      240

ctgcaaatga ccagcctgag agtcggggac acggccgtgt attactgtgc gaaagagagt      300

ttagactttg gttcagggag ctacaactgg ttcgacacct ggggccaggg aaccctggtc      360

actgtctcct ca                                                          372


<210> 1970
<211> 124
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region"

<400> 1970
Gln Val Gln Leu Val Gln Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Gln Ser 
            20                  25                  30          


Pro Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Gly Ile Ser Thr Gly Gly Thr Asn Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Thr Ser Leu Arg Val Gly Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Glu Ser Leu Asp Phe Gly Ser Gly Ser Tyr Asn Trp Phe Asp 
            100                 105                 110         


Thr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 


<210> 1971
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H1"

<400> 1971
Phe Thr Phe Ser Gln Ser Pro Met Ser 
1               5                   


<210> 1972
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H1"

<400> 1972
ttcaccttta gtcagtctcc catgagc                                           27


<210> 1973
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H2"

<400> 1973
Gly Ile Ser Thr Gly Gly Thr Asn Thr Tyr Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210> 1974
<211> 51
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H2"

<400> 1974
ggtattagta ctggagggac caatacatac tacgcagact ccgtgaaggg c                51


<210> 1975
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H3"

<400> 1975
Ala Lys Glu Ser Leu Asp Phe Gly Ser Gly Ser Tyr Asn Trp Phe Asp 
1               5                   10                  15      


Thr 
    


<210> 1976
<211> 51
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H3"

<400> 1976
gcgaaagaga gtttagactt tggttcaggg agctacaact ggttcgacac c                51


<210> 1977
<211> 336
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region"

<400> 1977
gaaattgtat tgacgcagtc tccagactcc ctggctgtgt ctctgggcga gagggccacc       60

atcaactgca agtccagcca gagtgtttta tacaggtcca acaataagaa ctacttagct      120

tggtaccagc agagaccagg acagcctcct aggctgctca tttcctgggc atctacccgg      180

gaatccgggg tccctgaccg attcactggc agcgggtctg ggacagattt cactctcacc      240

atcagcagcc tgcaggctga agatgtggca gtttattact gtcaccaata ttatgatacc      300

cacacttttg gccaggggac caaagtggat atcaaa                                336


<210> 1978
<211> 112
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region"

<400> 1978
Glu Ile Val Leu Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Glu Arg Ala Thr Ile Asn Cys Lys Ser Ser Gln Ser Val Leu Tyr Arg 
            20                  25                  30          


Ser Asn Asn Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Arg Pro Gly Gln 
        35                  40                  45              


Pro Pro Arg Leu Leu Ile Ser Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Leu Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys His Gln 
                85                  90                  95      


Tyr Tyr Asp Thr His Thr Phe Gly Gln Gly Thr Lys Val Asp Ile Lys 
            100                 105                 110         


<210> 1979
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L1"

<400> 1979
Lys Ser Ser Gln Ser Val Leu Tyr Arg Ser Asn Asn Lys Asn Tyr Leu 
1               5                   10                  15      


Ala 
    


<210> 1980
<211> 51
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L1"

<400> 1980
aagtccagcc agagtgtttt atacaggtcc aacaataaga actacttagc t                51


<210> 1981
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L2"

<400> 1981
Trp Ala Ser Thr Arg Glu Ser 
1               5           


<210> 1982
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L2"

<400> 1982
tgggcatcta cccgggaatc c                                                 21


<210> 1983
<211> 8
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L3"

<400> 1983
His Gln Tyr Tyr Asp Thr His Thr 
1               5               


<210> 1984
<211> 24
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L3"

<400> 1984
caccaatatt atgataccca cact                                              24


<210> 1985
<211> 366
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region"

<400> 1985
gaggtgcagc tggtggagtc tgggggaggc gtggtccagc ctgggaggtc cctgagactc       60

tcctgtgtag cctctggatt cagcttcagt gcctatggca tgcactgggt tcgccaggtt      120

ccaaccaagg ggctggagtg ggtggctgtt atatcatatg atggaagaga tatatactat      180

acagactccg tgaagggccg attcaccatt tccagagaca attccaagaa catgttgtat      240

ctgcaaatga acagcctgag acctgaggac agggctgtct attactgtgc gagagatccg      300

tccctcggtt ataataatca ctactttgac tattggggcc agggaaccct ggtcaccgtc      360

tcttca                                                                 366


<210> 1986
<211> 122
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region"

<400> 1986
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Val Ala Ser Gly Phe Ser Phe Ser Ala Tyr 
            20                  25                  30          


Gly Met His Trp Val Arg Gln Val Pro Thr Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Val Ile Ser Tyr Asp Gly Arg Asp Ile Tyr Tyr Thr Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Met Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Arg Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Pro Ser Leu Gly Tyr Asn Asn His Tyr Phe Asp Tyr Trp 
            100                 105                 110         


Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120         


<210> 1987
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H1"

<400> 1987
Phe Ser Phe Ser Ala Tyr Gly Met His 
1               5                   


<210> 1988
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H1"

<400> 1988
ttcagcttca gtgcctatgg catgcac                                           27


<210> 1989
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H2"

<400> 1989
Val Ile Ser Tyr Asp Gly Arg Asp Ile Tyr Tyr Thr Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210> 1990
<211> 51
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H2"

<400> 1990
gttatatcat atgatggaag agatatatac tatacagact ccgtgaaggg c                51


<210> 1991
<211> 15
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H3"

<400> 1991
Ala Arg Asp Pro Ser Leu Gly Tyr Asn Asn His Tyr Phe Asp Tyr 
1               5                   10                  15  


<210> 1992
<211> 45
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H3"

<400> 1992
gcgagagatc cgtccctcgg ttataataat cactactttg actat                       45


<210> 1993
<211> 327
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region"

<400> 1993
gaaattgtgt tgacgcagtc tccagccacc ctgtctttgt ctccagggga aacagccacc       60

ctctcctgca gggccagtca gagtgttacc ggcaacttag cctggtacca acagaaacct      120

ggccaggctc ccaggctcct catctatgct gcatccaaca gggccactgg catcccagcc      180

aggttcagtg gcagtgggtc tgggacagac ttcactctca ccatcagcag cctagagcct      240

gaagattttg cagtttattt ctgtcagcag cgtagcaact ggcctcctat gtacagtttt      300

ggccagggga ccaagctgga gatcaaa                                          327


<210> 1994
<211> 109
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region"

<400> 1994
Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Thr Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Thr Gly Asn 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Asn Arg Ala Thr Gly Ile Pro Ala Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Val Tyr Phe Cys Gln Gln Arg Ser Asn Trp Pro Pro 
                85                  90                  95      


Met Tyr Ser Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 


<210> 1995
<211> 11
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L1"

<400> 1995
Arg Ala Ser Gln Ser Val Thr Gly Asn Leu Ala 
1               5                   10      


<210> 1996
<211> 33
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L1"

<400> 1996
agggccagtc agagtgttac cggcaactta gcc                                    33


<210> 1997
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L2"

<400> 1997
Ala Ala Ser Asn Arg Ala Thr 
1               5           


<210> 1998
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L2"

<400> 1998
gctgcatcca acagggccac t                                                 21


<210> 1999
<211> 11
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L3"

<400> 1999
Gln Gln Arg Ser Asn Trp Pro Pro Met Tyr Ser 
1               5                   10      


<210> 2000
<211> 33
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L3"

<400> 2000
cagcagcgta gcaactggcc tcctatgtac agt                                    33


<210> 2001
<211> 375
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region"

<400> 2001
caggtccagc ttgtacagtc tggggctgag gtgaagaggc ctgggtcctc ggtgaaggtc       60

tcctgcaagg cctctggagg caccttcaga ggctaccata tcagctgggt gcgacaggcc      120

cctggacaag ggctcgagtg gatgggaggg atcatccatc tatttgggac agtaagctac      180

gctccgaagt tccagggcag agtcacgatc accgcggacg catccacggg cacagcccat      240

atggagttga gcagcctgac atctgacgac acggccatat actattgtgc gagagatgct      300

tacgaagtct ggacgggttc ttatctcccc ccttttgact actggggcca gggaaccctg      360

gtcaccgtct cctca                                                       375


<210> 2002
<211> 125
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region"

<400> 2002
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Arg Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Arg Gly Tyr 
            20                  25                  30          


His Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Gly Ile Ile His Leu Phe Gly Thr Val Ser Tyr Ala Pro Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Ala Asp Ala Ser Thr Gly Thr Ala His 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Thr Ser Asp Asp Thr Ala Ile Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Ala Tyr Glu Val Trp Thr Gly Ser Tyr Leu Pro Pro Phe 
            100                 105                 110         


Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125 


<210> 2003
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H1"

<400> 2003
Gly Thr Phe Arg Gly Tyr His Ile Ser 
1               5                   


<210> 2004
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H1"

<400> 2004
ggcaccttca gaggctacca tatcagc                                           27


<210> 2005
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H2"

<400> 2005
Gly Ile Ile His Leu Phe Gly Thr Val Ser Tyr Ala Pro Lys Phe Gln 
1               5                   10                  15      


Gly 
    


<210> 2006
<211> 51
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H2"

<400> 2006
gggatcatcc atctatttgg gacagtaagc tacgctccga agttccaggg c                51


<210> 2007
<211> 18
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H3"

<400> 2007
Ala Arg Asp Ala Tyr Glu Val Trp Thr Gly Ser Tyr Leu Pro Pro Phe 
1               5                   10                  15      


Asp Tyr 
        


<210> 2008
<211> 54
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H3"

<400> 2008
gcgagagatg cttacgaagt ctggacgggt tcttatctcc ccccttttga ctac             54


<210> 2009
<211> 324
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region"

<400> 2009
gatattgtga tgactcagac tccaggcacc ctgtctttgt ctcccgggga aagagtcacc       60

ctctcctgca gggccagtca gactgttaca agcagctact tagcctggta ccagcagaaa      120

cctggccagg ctcccagact cctcatctat ggtgcattca ccagggccac tggcatccca      180

gacaggttca gtggtagtgg gtctgggaca gacttcactc tcaccatcag cagactggag      240

cctgaagatt ttgcagtata ttactgtcag cagtatggta gctcattcct cactttcggc      300

ggagggacca agctggagat caaa                                             324


<210> 2010
<211> 108
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region"

<400> 2010
Asp Ile Val Met Thr Gln Thr Pro Gly Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Val Thr Leu Ser Cys Arg Ala Ser Gln Thr Val Thr Ser Ser 
            20                  25                  30          


Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu 
        35                  40                  45              


Ile Tyr Gly Ala Phe Thr Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu 
65                  70                  75                  80  


Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Gly Ser Ser Phe 
                85                  90                  95      


Leu Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105             


<210> 2011
<211> 12
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L1"

<400> 2011
Arg Ala Ser Gln Thr Val Thr Ser Ser Tyr Leu Ala 
1               5                   10          


<210> 2012
<211> 36
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L1"

<400> 2012
agggccagtc agactgttac aagcagctac ttagcc                                 36


<210> 2013
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L2"

<400> 2013
Gly Ala Phe Thr Arg Ala Thr 
1               5           


<210> 2014
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L2"

<400> 2014
ggtgcattca ccagggccac t                                                 21


<210> 2015
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L3"

<400> 2015
Gln Gln Tyr Gly Ser Ser Phe Leu Thr 
1               5                   


<210> 2016
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L3"

<400> 2016
cagcagtatg gtagctcatt cctcact                                           27


<210> 2017
<211> 372
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region"

<400> 2017
gaggtgcagc tggtggagtc tgggggaggc ctggtcaagc ctggggggtc cctgagactc       60

tcctgtgcag cctctggatt caccttcagt agctatagca tgaactgggt ccgccaggct      120

ccagggaagg ggctggagtg ggtctcatcc attagtagta gtagtagtta catatactac      180

gcagactcag tgaagggccg attcaccatc tccagagaca acgccaagaa ctcactgtat      240

ctgcaaatga acagcctgag agccgaggac acggctgtgt attactgtgc gagagatgtg      300

caatatagtg gctacgattc tgggtactac tttgactact ggggccaggg aaccctggtc      360

actgtctcct ca                                                          372


<210> 2018
<211> 124
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region"

<400> 2018
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ser Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ser Ile Ser Ser Ser Ser Ser Tyr Ile Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Val Gln Tyr Ser Gly Tyr Asp Ser Gly Tyr Tyr Phe Asp 
            100                 105                 110         


Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 


<210> 2019
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H1"

<400> 2019
Phe Thr Phe Ser Ser Tyr Ser Met Asn 
1               5                   


<210> 2020
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H1"

<400> 2020
ttcaccttca gtagctatag catgaac                                           27


<210> 2021
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H2"

<400> 2021
Ser Ile Ser Ser Ser Ser Ser Tyr Ile Tyr Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210> 2022
<211> 51
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H2"

<400> 2022
tccattagta gtagtagtag ttacatatac tacgcagact cagtgaaggg c                51


<210> 2023
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H3"

<400> 2023
Ala Arg Asp Val Gln Tyr Ser Gly Tyr Asp Ser Gly Tyr Tyr Phe Asp 
1               5                   10                  15      


Tyr 
    


<210> 2024
<211> 51
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H3"

<400> 2024
gcgagagatg tgcaatatag tggctacgat tctgggtact actttgacta c                51


<210> 2025
<211> 336
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region"

<400> 2025
cagcctgtgc tgactcagcc accctcagtg tctggggccc caggacagag ggtcaccatc       60

tcctgcactg ggagcagctc caacatcggg gcaggttatg atgtacactg gtaccagcag      120

cttccaggaa cagcccccaa actcctcatc tatggtaaca gcaatcggcc ctcaggggtc      180

cctgaccgat tctctggctc caagtctggc acctcagcct ccctggccat cactgggctc      240

caggctgagg atgaggctga ttattactgc cagtcctatg acagcagcct gagtgccctt      300

tatgtcttcg gaactgggac caaggtgacc gtccta                                336


<210> 2026
<211> 112
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region"

<400> 2026
Gln Pro Val Leu Thr Gln Pro Pro Ser Val Ser Gly Ala Pro Gly Gln 
1               5                   10                  15      


Arg Val Thr Ile Ser Cys Thr Gly Ser Ser Ser Asn Ile Gly Ala Gly 
            20                  25                  30          


Tyr Asp Val His Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu 
        35                  40                  45              


Leu Ile Tyr Gly Asn Ser Asn Arg Pro Ser Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Thr Gly Leu 
65                  70                  75                  80  


Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Gln Ser Tyr Asp Ser Ser 
                85                  90                  95      


Leu Ser Ala Leu Tyr Val Phe Gly Thr Gly Thr Lys Val Thr Val Leu 
            100                 105                 110         


<210> 2027
<211> 14
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L1"

<400> 2027
Thr Gly Ser Ser Ser Asn Ile Gly Ala Gly Tyr Asp Val His 
1               5                   10                  


<210> 2028
<211> 42
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L1"

<400> 2028
actgggagca gctccaacat cggggcaggt tatgatgtac ac                          42


<210> 2029
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L2"

<400> 2029
Gly Asn Ser Asn Arg Pro Ser 
1               5           


<210> 2030
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L2"

<400> 2030
ggtaacagca atcggccctc a                                                 21


<210> 2031
<211> 12
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L3"

<400> 2031
Gln Ser Tyr Asp Ser Ser Leu Ser Ala Leu Tyr Val 
1               5                   10          


<210> 2032
<211> 36
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L3"

<400> 2032
cagtcctatg acagcagcct gagtgccctt tatgtc                                 36


<210> 2033
<211> 360
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region"

<400> 2033
gaggtgcagc tggtggagtc tgggggaggc gtggtccagc cgggggggtc cctgagactc       60

tcctgtgcag gctctggatt cgccttcggt agcttcgcga tgcactgggt ccgtcaggct      120

ccaggcaagg ggctggagtg ggtggctgtt atttcatttg acggaaagaa tacaaaatat      180

gctgactccg tgaagggccg attcaccacc tccagagaca attccaggaa cacgctctat      240

ctccaaatgg acagcctgag aggtgacgac acggctatat attactgcgc gacaattagg      300

ggaattgtgg ctggcctttg tgacaactgg ggccagggaa ccctggtcac cgtctcctca      360


<210> 2034
<211> 120
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region"

<400> 2034
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Gly Ser Gly Phe Ala Phe Gly Ser Phe 
            20                  25                  30          


Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Val Ile Ser Phe Asp Gly Lys Asn Thr Lys Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Thr Ser Arg Asp Asn Ser Arg Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asp Ser Leu Arg Gly Asp Asp Thr Ala Ile Tyr Tyr Cys 
                85                  90                  95      


Ala Thr Ile Arg Gly Ile Val Ala Gly Leu Cys Asp Asn Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser 
        115                 120 


<210> 2035
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H1"

<400> 2035
Phe Ala Phe Gly Ser Phe Ala Met His 
1               5                   


<210> 2036
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H1"

<400> 2036
ttcgccttcg gtagcttcgc gatgcac                                           27


<210> 2037
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H2"

<400> 2037
Val Ile Ser Phe Asp Gly Lys Asn Thr Lys Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210> 2038
<211> 51
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H2"

<400> 2038
gttatttcat ttgacggaaa gaatacaaaa tatgctgact ccgtgaaggg c                51


<210> 2039
<211> 13
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H3"

<400> 2039
Ala Thr Ile Arg Gly Ile Val Ala Gly Leu Cys Asp Asn 
1               5                   10              


<210> 2040
<211> 39
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H3"

<400> 2040
gcgacaatta ggggaattgt ggctggcctt tgtgacaac                              39


<210> 2041
<211> 336
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region"

<400> 2041
cagcctgtgc tgactcaatc atcgtctgac tctgcttccc tgggagcctc ggtcaagctc       60

acctgtactc tgagcagtgg ccacagaaac tacatcatcg catggcatca acaacaacca      120

gggaaggccc ctcggttcct gatgaaggtt gaaggtagtg gaagcttcac catggggagc      180

ggagttcctg atcgcttctc gggctccagc tctggggctg accgctacct caccatctcc      240

aacctccagt ctgaggatga ggctgattat tactgtgagg cctgggactt taacacgggg      300

ggggtcttcg gcggaggcac ccagctgacc gtcctc                                336


<210> 2042
<211> 112
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region"

<400> 2042
Gln Pro Val Leu Thr Gln Ser Ser Ser Asp Ser Ala Ser Leu Gly Ala 
1               5                   10                  15      


Ser Val Lys Leu Thr Cys Thr Leu Ser Ser Gly His Arg Asn Tyr Ile 
            20                  25                  30          


Ile Ala Trp His Gln Gln Gln Pro Gly Lys Ala Pro Arg Phe Leu Met 
        35                  40                  45              


Lys Val Glu Gly Ser Gly Ser Phe Thr Met Gly Ser Gly Val Pro Asp 
    50                  55                  60                  


Arg Phe Ser Gly Ser Ser Ser Gly Ala Asp Arg Tyr Leu Thr Ile Ser 
65                  70                  75                  80  


Asn Leu Gln Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Glu Ala Trp Asp 
                85                  90                  95      


Phe Asn Thr Gly Gly Val Phe Gly Gly Gly Thr Gln Leu Thr Val Leu 
            100                 105                 110         


<210> 2043
<211> 12
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L1"

<400> 2043
Thr Leu Ser Ser Gly His Arg Asn Tyr Ile Ile Ala 
1               5                   10          


<210> 2044
<211> 36
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L1"

<400> 2044
actctgagca gtggccacag aaactacatc atcgca                                 36


<210> 2045
<211> 11
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L2"

<400> 2045
Val Glu Gly Ser Gly Ser Phe Thr Met Gly Ser 
1               5                   10      


<210> 2046
<211> 33
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L2"

<400> 2046
gttgaaggta gtggaagctt caccatgggg agc                                    33


<210> 2047
<211> 10
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L3"

<400> 2047
Glu Ala Trp Asp Phe Asn Thr Gly Gly Val 
1               5                   10  


<210> 2048
<211> 30
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L3"

<400> 2048
gaggcctggg actttaacac ggggggggtc                                        30


<210> 2049
<211> 375
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region"

<400> 2049
gaggtgcagc tggtggagtc gggcccagga ctggtgaagc cttcggggac cctgtccctc       60

acctgcgctg tctctggtga ctccatcgtc ggtagtgact ggtggagttg gatccgccag      120

ccccccggga aggggctgga gtggattgga gatatctatc atggtgggac caccagctac      180

aacccgtccc ttaagagtcg agtcaccatg tcagtagaca agtccaagaa ccaattctcc      240

ctgaagctga cctctgtcac cgccgcggac acagccgtgt attactgtgc gagactctcg      300

ggaaattgta gtggtggtag ctgttactcg ccctttgacc actggggcca gggaaccctg      360

gtcaccgtct cttca                                                       375


<210> 2050
<211> 125
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region"

<400> 2050
Glu Val Gln Leu Val Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gly 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Ala Val Ser Gly Asp Ser Ile Val Gly Ser 
            20                  25                  30          


Asp Trp Trp Ser Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp 
        35                  40                  45              


Ile Gly Asp Ile Tyr His Gly Gly Thr Thr Ser Tyr Asn Pro Ser Leu 
    50                  55                  60                  


Lys Ser Arg Val Thr Met Ser Val Asp Lys Ser Lys Asn Gln Phe Ser 
65                  70                  75                  80  


Leu Lys Leu Thr Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Leu Ser Gly Asn Cys Ser Gly Gly Ser Cys Tyr Ser Pro Phe 
            100                 105                 110         


Asp His Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125 


<210> 2051
<211> 10
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H1"

<400> 2051
Asp Ser Ile Val Gly Ser Asp Trp Trp Ser 
1               5                   10  


<210> 2052
<211> 30
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H1"

<400> 2052
gactccatcg tcggtagtga ctggtggagt                                        30


<210> 2053
<211> 16
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H2"

<400> 2053
Asp Ile Tyr His Gly Gly Thr Thr Ser Tyr Asn Pro Ser Leu Lys Ser 
1               5                   10                  15      


<210> 2054
<211> 48
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H2"

<400> 2054
gatatctatc atggtgggac caccagctac aacccgtccc ttaagagt                    48


<210> 2055
<211> 18
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H3"

<400> 2055
Ala Arg Leu Ser Gly Asn Cys Ser Gly Gly Ser Cys Tyr Ser Pro Phe 
1               5                   10                  15      


Asp His 
        


<210> 2056
<211> 54
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H3"

<400> 2056
gcgagactct cgggaaattg tagtggtggt agctgttact cgccctttga ccac             54


<210> 2057
<211> 321
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region"

<400> 2057
gacatccaga tgacccagtc tccatcctcc ttgtctgcat ctgtgggaga cagagtcacc       60

atcacttgcc gggcaagtca gaccattaat ggttatttaa attggtatca acaaagacca      120

gggaaagccc ctaaactcct gatctctgct gcatccagtt tgcagagtgg ggtcccatca      180

aggttccgtg gcagtggata tgggacagat ttcactctca ccatcagcag tctgcaacct      240

gaagattttg caacttattt ctgtcaacag agttacaata ctgtgtacac ttttgggcag      300

gggaccaaag tggatatcaa a                                                321


<210> 2058
<211> 107
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region"

<400> 2058
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Thr Ile Asn Gly Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Arg Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Ser Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Arg Gly 
    50                  55                  60                  


Ser Gly Tyr Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Phe Cys Gln Gln Ser Tyr Asn Thr Val Tyr 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Asp Ile Lys 
            100                 105         


<210> 2059
<211> 11
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L1"

<400> 2059
Arg Ala Ser Gln Thr Ile Asn Gly Tyr Leu Asn 
1               5                   10      


<210> 2060
<211> 33
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L1"

<400> 2060
cgggcaagtc agaccattaa tggttattta aat                                    33


<210> 2061
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L2"

<400> 2061
Ala Ala Ser Ser Leu Gln Ser 
1               5           


<210> 2062
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L2"

<400> 2062
gctgcatcca gtttgcagag t                                                 21


<210> 2063
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L3"

<400> 2063
Gln Gln Ser Tyr Asn Thr Val Tyr Thr 
1               5                   


<210> 2064
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L3"

<400> 2064
caacagagtt acaatactgt gtacact                                           27


<210> 2065
<211> 357
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region"

<400> 2065
caggtgcagc tggtgcagtc tggagcagag gtgaaaaagc ccggggagtc tctgaagatc       60

tcctgtaagg gttctggata cagctttagc agctactgga tcggctgggt gcgccagatg      120

cccgggaaag gcctggagtg gatggggatc atctatcctg gtgactctga taccagatac      180

agcccgtcgc tccaaggcca ggtcaccatc tcaggcgaca agtccatcag taccgccttc      240

ctgcagtgga gcagcctgaa ggcctcggac accgccatgt attactgtgc gagacccatg      300

actacccaag aaggttttga tttgtggggc caagggacaa tggtcaccgt ctcttca         357


<210> 2066
<211> 119
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region"

<400> 2066
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu 
1               5                   10                  15      


Ser Leu Lys Ile Ser Cys Lys Gly Ser Gly Tyr Ser Phe Ser Ser Tyr 
            20                  25                  30          


Trp Ile Gly Trp Val Arg Gln Met Pro Gly Lys Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Ile Ile Tyr Pro Gly Asp Ser Asp Thr Arg Tyr Ser Pro Ser Leu 
    50                  55                  60                  


Gln Gly Gln Val Thr Ile Ser Gly Asp Lys Ser Ile Ser Thr Ala Phe 
65                  70                  75                  80  


Leu Gln Trp Ser Ser Leu Lys Ala Ser Asp Thr Ala Met Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Pro Met Thr Thr Gln Glu Gly Phe Asp Leu Trp Gly Gln Gly 
            100                 105                 110         


Thr Met Val Thr Val Ser Ser 
        115                 


<210> 2067
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H1"

<400> 2067
Tyr Ser Phe Ser Ser Tyr Trp Ile Gly 
1               5                   


<210> 2068
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H1"

<400> 2068
tacagcttta gcagctactg gatcggc                                           27


<210> 2069
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H2"

<400> 2069
Ile Ile Tyr Pro Gly Asp Ser Asp Thr Arg Tyr Ser Pro Ser Leu Gln 
1               5                   10                  15      


Gly 
    


<210> 2070
<211> 51
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H2"

<400> 2070
atcatctatc ctggtgactc tgataccaga tacagcccgt cgctccaagg c                51


<210> 2071
<211> 12
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H3"

<400> 2071
Ala Arg Pro Met Thr Thr Gln Glu Gly Phe Asp Leu 
1               5                   10          


<210> 2072
<211> 36
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H3"

<400> 2072
gcgagaccca tgactaccca agaaggtttt gatttg                                 36


<210> 2073
<211> 324
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region"

<400> 2073
gacatccggt tgacccagtc tccatcttct gtgtctgcat ctgtaggaga cagagtcacc       60

atcacttgtc gggcgagtca gggtattagc gactggttag cctggtatca gcagaaacca      120

gggaaagccc ctaaactcct gatctatgct gcatccagtt tgcaaagtgg ggtcccatca      180

aggttcagcg gcagtggatc tgggacagat ttcactctca ctatcagcag cctgcagcct      240

gaagattttg caacttacta ttgtcaacag actaacagtt tcctcccgct cactttcggc      300

ggagggacca aagtggatat caaa                                             324


<210> 2074
<211> 108
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region"

<400> 2074
Asp Ile Arg Leu Thr Gln Ser Pro Ser Ser Val Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Ser Asp Trp 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Thr Asn Ser Phe Leu Pro 
                85                  90                  95      


Leu Thr Phe Gly Gly Gly Thr Lys Val Asp Ile Lys 
            100                 105             


<210> 2075
<211> 11
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L1"

<400> 2075
Arg Ala Ser Gln Gly Ile Ser Asp Trp Leu Ala 
1               5                   10      


<210> 2076
<211> 33
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L1"

<400> 2076
cgggcgagtc agggtattag cgactggtta gcc                                    33


<210> 2077
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L2"

<400> 2077
Ala Ala Ser Ser Leu Gln Ser 
1               5           


<210> 2078
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L2"

<400> 2078
gctgcatcca gtttgcaaag t                                                 21


<210> 2079
<211> 10
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L3"

<400> 2079
Gln Gln Thr Asn Ser Phe Leu Pro Leu Thr 
1               5                   10  


<210> 2080
<211> 30
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L3"

<400> 2080
caacagacta acagtttcct cccgctcact                                        30


<210> 2081
<211> 378
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region"

<400> 2081
gaggtgcagc tggtggagtc gggcccccga ctggtgaagc cttcacagac cctgtccctc       60

acctgcaccg tctatggtgg ctccatcagc ggtggtcaaa actactacag ttgggtccgc      120

cagcccccag ggaagggcct ggagtggatt gggtacatct tttccagtgg gaccacctac      180

tacaagccgt ccctcaagag tcgaatttcc atttcatttg acacgtccaa gaaccagttc      240

tccctgaacc tggcctctgt gacggccgca gacacggccg tatatttctg tgccagatcc      300

gctgacattg atatcgtttg ggggagttct ctctacatgc ctctctgggg ccagggaacc      360

ctggtcaccg tctcctca                                                    378


<210> 2082
<211> 126
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region"

<400> 2082
Glu Val Gln Leu Val Glu Ser Gly Pro Arg Leu Val Lys Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Tyr Gly Gly Ser Ile Ser Gly Gly 
            20                  25                  30          


Gln Asn Tyr Tyr Ser Trp Val Arg Gln Pro Pro Gly Lys Gly Leu Glu 
        35                  40                  45              


Trp Ile Gly Tyr Ile Phe Ser Ser Gly Thr Thr Tyr Tyr Lys Pro Ser 
    50                  55                  60                  


Leu Lys Ser Arg Ile Ser Ile Ser Phe Asp Thr Ser Lys Asn Gln Phe 
65                  70                  75                  80  


Ser Leu Asn Leu Ala Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Phe 
                85                  90                  95      


Cys Ala Arg Ser Ala Asp Ile Asp Ile Val Trp Gly Ser Ser Leu Tyr 
            100                 105                 110         


Met Pro Leu Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125     


<210> 2083
<211> 11
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H1"

<400> 2083
Gly Ser Ile Ser Gly Gly Gln Asn Tyr Tyr Ser 
1               5                   10      


<210> 2084
<211> 33
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H1"

<400> 2084
ggctccatca gcggtggtca aaactactac agt                                    33


<210> 2085
<211> 16
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H2"

<400> 2085
Tyr Ile Phe Ser Ser Gly Thr Thr Tyr Tyr Lys Pro Ser Leu Lys Ser 
1               5                   10                  15      


<210> 2086
<211> 48
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H2"

<400> 2086
tacatctttt ccagtgggac cacctactac aagccgtccc tcaagagt                    48


<210> 2087
<211> 18
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H3"

<400> 2087
Ala Arg Ser Ala Asp Ile Asp Ile Val Trp Gly Ser Ser Leu Tyr Met 
1               5                   10                  15      


Pro Leu 
        


<210> 2088
<211> 54
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H3"

<400> 2088
gccagatccg ctgacattga tatcgtttgg gggagttctc tctacatgcc tctc             54


<210> 2089
<211> 324
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region"

<400> 2089
gaaattgtgt tgacgcagtc tccaggcacc ctgtctttgt ctccaggaca aagagccacc       60

ctctcctgca gggccactca cattgtcagt aacagctact tagcctggta ccagcagaaa      120

cctggccagg ctcccaggct cctcatccat ggtgtttcca tcagggccac tggcatccca      180

gacaggttct ctggcagtgg gtctgggaca gacttcactc tcaccatcag cagactggag      240

cctgaagatt ttgcagtgta tttctgtcag cagtatggta cctcaccgtg gacgttcggc      300

caagggacca agctggagat caaa                                             324


<210> 2090
<211> 108
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region"

<400> 2090
Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Gln Arg Ala Thr Leu Ser Cys Arg Ala Thr His Ile Val Ser Asn Ser 
            20                  25                  30          


Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu 
        35                  40                  45              


Ile His Gly Val Ser Ile Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu 
65                  70                  75                  80  


Pro Glu Asp Phe Ala Val Tyr Phe Cys Gln Gln Tyr Gly Thr Ser Pro 
                85                  90                  95      


Trp Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105             


<210> 2091
<211> 12
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L1"

<400> 2091
Arg Ala Thr His Ile Val Ser Asn Ser Tyr Leu Ala 
1               5                   10          


<210> 2092
<211> 36
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L1"

<400> 2092
agggccactc acattgtcag taacagctac ttagcc                                 36


<210> 2093
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L2"

<400> 2093
Gly Val Ser Ile Arg Ala Thr 
1               5           


<210> 2094
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L2"

<400> 2094
ggtgtttcca tcagggccac t                                                 21


<210> 2095
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L3"

<400> 2095
Gln Gln Tyr Gly Thr Ser Pro Trp Thr 
1               5                   


<210> 2096
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L3"

<400> 2096
cagcagtatg gtacctcacc gtggacg                                           27


<210> 2097
<211> 372
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region"

<400> 2097
caggtgcagc tggtggagtc tgggggaggc ctggtcaagc cgggggggtc cctgagactc       60

tcctgtgtag cctctggatt taccttcagc agttatgcca tgaattgggt ccgccaggct      120

ccagggaagg ggctggactg ggtctcctct atcagtgctg gtagcaattt catagacgac      180

gcagactcag tgaagggccg cttcaccatc tccagagaca acgccaggaa ctcactgttt      240

ctgcagatga acagcctgag agccgaggac acggctgtgt attactgtgc gagaattggg      300

tacagtagcg cgcaccacta ccagtactac atggacgtct ggggcacggg gaccacggtc      360

accgtctcct ca                                                          372


<210> 2098
<211> 124
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region"

<400> 2098
Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Val Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Asp Trp Val 
        35                  40                  45              


Ser Ser Ile Ser Ala Gly Ser Asn Phe Ile Asp Asp Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Arg Asn Ser Leu Phe 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ile Gly Tyr Ser Ser Ala His His Tyr Gln Tyr Tyr Met Asp 
            100                 105                 110         


Val Trp Gly Thr Gly Thr Thr Val Thr Val Ser Ser 
        115                 120                 


<210> 2099
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H1"

<400> 2099
Phe Thr Phe Ser Ser Tyr Ala Met Asn 
1               5                   


<210> 2100
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H1"

<400> 2100
tttaccttca gcagttatgc catgaat                                           27


<210> 2101
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H2"

<400> 2101
Ser Ile Ser Ala Gly Ser Asn Phe Ile Asp Asp Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210> 2102
<211> 51
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H2"

<400> 2102
tctatcagtg ctggtagcaa tttcatagac gacgcagact cagtgaaggg c                51


<210> 2103
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H3"

<400> 2103
Ala Arg Ile Gly Tyr Ser Ser Ala His His Tyr Gln Tyr Tyr Met Asp 
1               5                   10                  15      


Val 
    


<210> 2104
<211> 51
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H3"

<400> 2104
gcgagaattg ggtacagtag cgcgcaccac taccagtact acatggacgt c                51


<210> 2105
<211> 336
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region"

<400> 2105
cagtctgtcc tgacgcagcc gccctcagtg tctggggccc cagggcagag ggtcaccatc       60

tcctgcactg gcagcagctc caacatcggg gcaggttatg atgtccactg gtaccaggat      120

cttccaggaa ctgcccccaa actcctcatc tatggtaaca ccaatcggcc ctcaggggtc      180

cctgaccgat tctctggctc caagtctggc gcctcagcct ccctggtcat cactgggctc      240

caggctgagg atgaggctga ttattactgc cagtcctatg acaagagcct gagtggtggg      300

tatgtcttcg gaactgggac caaggtcacc gtccta                                336


<210> 2106
<211> 112
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region"

<400> 2106
Gln Ser Val Leu Thr Gln Pro Pro Ser Val Ser Gly Ala Pro Gly Gln 
1               5                   10                  15      


Arg Val Thr Ile Ser Cys Thr Gly Ser Ser Ser Asn Ile Gly Ala Gly 
            20                  25                  30          


Tyr Asp Val His Trp Tyr Gln Asp Leu Pro Gly Thr Ala Pro Lys Leu 
        35                  40                  45              


Leu Ile Tyr Gly Asn Thr Asn Arg Pro Ser Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Ala Ser Ala Ser Leu Val Ile Thr Gly Leu 
65                  70                  75                  80  


Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Gln Ser Tyr Asp Lys Ser 
                85                  90                  95      


Leu Ser Gly Gly Tyr Val Phe Gly Thr Gly Thr Lys Val Thr Val Leu 
            100                 105                 110         


<210> 2107
<211> 14
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L1"

<400> 2107
Thr Gly Ser Ser Ser Asn Ile Gly Ala Gly Tyr Asp Val His 
1               5                   10                  


<210> 2108
<211> 42
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L1"

<400> 2108
actggcagca gctccaacat cggggcaggt tatgatgtcc ac                          42


<210> 2109
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L2"

<400> 2109
Gly Asn Thr Asn Arg Pro Ser 
1               5           


<210> 2110
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L2"

<400> 2110
ggtaacacca atcggccctc a                                                 21


<210> 2111
<211> 12
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L3"

<400> 2111
Gln Ser Tyr Asp Lys Ser Leu Ser Gly Gly Tyr Val 
1               5                   10          


<210> 2112
<211> 36
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L3"

<400> 2112
cagtcctatg acaagagcct gagtggtggg tatgtc                                 36


<210> 2113
<211> 363
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region"

<400> 2113
caggtccagc tggtgcagtc tggggctgag gtgaagaagc ctggggcctc agtgagggtc       60

acctgcaagg cctctggata caccttcacc gactacttta tgaactgggt gcgacaggcc      120

cctggagggg gccttgagtg gatggggtgg atcaatcctc tcagtggagt cacaaaatat      180

gcacagcagt ttcagggcag tgtcaccatg accactgaca cgtccatcac cacaggctac      240

atggagctga ggagcctgag agttgacgac acggccgtct attattgtgc gagccagtct      300

tccccttaca ccccgggcgc catgggcgtc tggggccaag ggaccacggt caccgtctct      360

tca                                                                    363


<210> 2114
<211> 121
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region"

<400> 2114
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Arg Val Thr Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Tyr 
            20                  25                  30          


Phe Met Asn Trp Val Arg Gln Ala Pro Gly Gly Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Asn Pro Leu Ser Gly Val Thr Lys Tyr Ala Gln Gln Phe 
    50                  55                  60                  


Gln Gly Ser Val Thr Met Thr Thr Asp Thr Ser Ile Thr Thr Gly Tyr 
65                  70                  75                  80  


Met Glu Leu Arg Ser Leu Arg Val Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ser Gln Ser Ser Pro Tyr Thr Pro Gly Ala Met Gly Val Trp Gly 
            100                 105                 110         


Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120     


<210> 2115
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H1"

<400> 2115
Tyr Thr Phe Thr Asp Tyr Phe Met Asn 
1               5                   


<210> 2116
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H1"

<400> 2116
tacaccttca ccgactactt tatgaac                                           27


<210> 2117
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H2"

<400> 2117
Trp Ile Asn Pro Leu Ser Gly Val Thr Lys Tyr Ala Gln Gln Phe Gln 
1               5                   10                  15      


Gly 
    


<210> 2118
<211> 51
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H2"

<400> 2118
tggatcaatc ctctcagtgg agtcacaaaa tatgcacagc agtttcaggg c                51


<210> 2119
<211> 14
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H3"

<400> 2119
Ala Ser Gln Ser Ser Pro Tyr Thr Pro Gly Ala Met Gly Val 
1               5                   10                  


<210> 2120
<211> 42
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H3"

<400> 2120
gcgagccagt cttcccctta caccccgggc gccatgggcg tc                          42


<210> 2121
<211> 327
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region"

<400> 2121
tcctatgagc tgatacagct accctcggtg tcagtgtccc caggacagac ggccaggatc       60

acctgctctg gagatgcatt gccaaagcaa tatgcttatt ggtaccagca gaagccaggc      120

caggcccctg tgctggtgat atataaagac agtgagaggc cctcagggat ccctgagcga      180

ttctctggct ccagctcagg gacaacagtc acgttgacca tcagtggagt ccaggcagaa      240

gacgaggctg actattactg tcaatcagca gacagcagtg gtacttatcc ggtggtgttc      300

ggcggaggga ccaagctcac cgtccta                                          327


<210> 2122
<211> 109
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region"

<400> 2122
Ser Tyr Glu Leu Ile Gln Leu Pro Ser Val Ser Val Ser Pro Gly Gln 
1               5                   10                  15      


Thr Ala Arg Ile Thr Cys Ser Gly Asp Ala Leu Pro Lys Gln Tyr Ala 
            20                  25                  30          


Tyr Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Val Leu Val Ile Tyr 
        35                  40                  45              


Lys Asp Ser Glu Arg Pro Ser Gly Ile Pro Glu Arg Phe Ser Gly Ser 
    50                  55                  60                  


Ser Ser Gly Thr Thr Val Thr Leu Thr Ile Ser Gly Val Gln Ala Glu 
65                  70                  75                  80  


Asp Glu Ala Asp Tyr Tyr Cys Gln Ser Ala Asp Ser Ser Gly Thr Tyr 
                85                  90                  95      


Pro Val Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 


<210> 2123
<211> 11
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L1"

<400> 2123
Ser Gly Asp Ala Leu Pro Lys Gln Tyr Ala Tyr 
1               5                   10      


<210> 2124
<211> 33
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L1"

<400> 2124
tctggagatg cattgccaaa gcaatatgct tat                                    33


<210> 2125
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L2"

<400> 2125
Lys Asp Ser Glu Arg Pro Ser 
1               5           


<210> 2126
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L2"

<400> 2126
aaagacagtg agaggccctc a                                                 21


<210> 2127
<211> 12
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L3"

<400> 2127
Gln Ser Ala Asp Ser Ser Gly Thr Tyr Pro Val Val 
1               5                   10          


<210> 2128
<211> 36
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L3"

<400> 2128
caatcagcag acagcagtgg tacttatccg gtggtg                                 36


<210> 2129
<211> 366
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region"

<400> 2129
gaggtgcagc tggtggagtc gggcccagga ctggtggagc cttcggagac cctgtccctc       60

acctgcactg tctctggtgc ctccatcagc agtagtgaat actactgggg ctggatccgc      120

cagcccccag ggaaggggct ggagtggatt gggactttct attatagtgg gagcacctac      180

tacaacccgt ccctcaagag tcgagtcacc atatccgaag acacgtccaa gaatcagctc      240

tccctgaagt tgagctctgt gaccgccgta gacacggctg tgtattactg tgcgagacac      300

agcagatccg acgtccggaa ctacttcgac ccctggggcc agggaaccct ggtcaccgtc      360

tcctca                                                                 366


<210> 2130
<211> 122
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region"

<400> 2130
Glu Val Gln Leu Val Glu Ser Gly Pro Gly Leu Val Glu Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Ala Ser Ile Ser Ser Ser 
            20                  25                  30          


Glu Tyr Tyr Trp Gly Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu 
        35                  40                  45              


Trp Ile Gly Thr Phe Tyr Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro Ser 
    50                  55                  60                  


Leu Lys Ser Arg Val Thr Ile Ser Glu Asp Thr Ser Lys Asn Gln Leu 
65                  70                  75                  80  


Ser Leu Lys Leu Ser Ser Val Thr Ala Val Asp Thr Ala Val Tyr Tyr 
                85                  90                  95      


Cys Ala Arg His Ser Arg Ser Asp Val Arg Asn Tyr Phe Asp Pro Trp 
            100                 105                 110         


Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120         


<210> 2131
<211> 11
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H1"

<400> 2131
Ala Ser Ile Ser Ser Ser Glu Tyr Tyr Trp Gly 
1               5                   10      


<210> 2132
<211> 33
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H1"

<400> 2132
gcctccatca gcagtagtga atactactgg ggc                                    33


<210> 2133
<211> 16
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H2"

<400> 2133
Thr Phe Tyr Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro Ser Leu Lys Ser 
1               5                   10                  15      


<210> 2134
<211> 48
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H2"

<400> 2134
actttctatt atagtgggag cacctactac aacccgtccc tcaagagt                    48


<210> 2135
<211> 14
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H3"

<400> 2135
Ala Arg His Ser Arg Ser Asp Val Arg Asn Tyr Phe Asp Pro 
1               5                   10                  


<210> 2136
<211> 42
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H3"

<400> 2136
gcgagacaca gcagatccga cgtccggaac tacttcgacc cc                          42


<210> 2137
<211> 321
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region"

<400> 2137
gaaattgtga tgacacagtc tccatcctcc ctgtctgcag ctgtaggaga cagcgtcacc       60

atcacttgcc gggcaagtca gagcatcagc aactatttaa attggtatca gcagaaatca      120

gggaaagccc ctaagctcct gatctatgct gcatccagtt tgcaaagtgg ggtcccatca      180

aggttcagtg gcagtggatc tgggacagat ttcactctca ctatcagcag tctgcaacct      240

gaagattttt caacttacta ctgtcaacag agtcacagta cccccgccac ttttggcctg      300

gggaccaaag tggatatcaa a                                                321


<210> 2138
<211> 107
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region"

<400> 2138
Glu Ile Val Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ala Val Gly 
1               5                   10                  15      


Asp Ser Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Asn Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Ser Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ser Thr Tyr Tyr Cys Gln Gln Ser His Ser Thr Pro Ala 
                85                  90                  95      


Thr Phe Gly Leu Gly Thr Lys Val Asp Ile Lys 
            100                 105         


<210> 2139
<211> 11
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L1"

<400> 2139
Arg Ala Ser Gln Ser Ile Ser Asn Tyr Leu Asn 
1               5                   10      


<210> 2140
<211> 33
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L1"

<400> 2140
cgggcaagtc agagcatcag caactattta aat                                    33


<210> 2141
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L2"

<400> 2141
Ala Ala Ser Ser Leu Gln Ser 
1               5           


<210> 2142
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L2"

<400> 2142
gctgcatcca gtttgcaaag t                                                 21


<210> 2143
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L3"

<400> 2143
Gln Gln Ser His Ser Thr Pro Ala Thr 
1               5                   


<210> 2144
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L3"

<400> 2144
caacagagtc acagtacccc cgccact                                           27


<210> 2145
<211> 366
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      Heavy chain variable region ('HC') nucleic acid sequence"

<400> 2145
gaggtgcagc tggtggagtc tgggggaggc ctggtcaagc ctgggggggc cctgagactc       60

tcctgtgcag cctctggatt cagcttcagg agctatagca tgaactgggt ccgccaggct      120

ccagggaagg ggctggagtg ggtctcatcc attagtagta gtagtaatta cataaactac      180

gcagactcag tgaagggccg attcagcatc tccagagaca acgccaagaa ctcactgtat      240

ctgcaaatga acagcctgag agccgaggac acggctgtct attactgtgc gagagatttg      300

ttacccgtcg agcggggtcc cgcttttgat atctggggcc aagggacaat ggtcaccgtc      360

tcttca                                                                 366


<210> 2146
<211> 122
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      Heavy chain variable region ('HC') amino acid sequence"

<400> 2146
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ala Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ser Phe Arg Ser Tyr 
            20                  25                  30          


Ser Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ser Ile Ser Ser Ser Ser Asn Tyr Ile Asn Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Ser Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Leu Leu Pro Val Glu Arg Gly Pro Ala Phe Asp Ile Trp 
            100                 105                 110         


Gly Gln Gly Thr Met Val Thr Val Ser Ser 
        115                 120         


<210> 2147
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H1 ('H1') amino acid sequence"

<400> 2147
Phe Ser Phe Arg Ser Tyr Ser Met Asn 
1               5                   


<210> 2148
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H2 ('H2') amino acid sequence"

<400> 2148
Ser Ile Ser Ser Ser Ser Asn Tyr Ile Asn Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210> 2149
<211> 15
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H3 ('H3') amino acid sequence"

<400> 2149
Ala Arg Asp Leu Leu Pro Val Glu Arg Gly Pro Ala Phe Asp Ile 
1               5                   10                  15  


<210> 2150
<211> 333
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      Light chain variable region('LC') nucleic acid sequence"

<400> 2150
tcctacgagc tgacacagcc accctcagtg tctggggccc cagggcagag ggtcactatc       60

tcctgcactg ggagcagctc caacatcggg aggggttatg atgtacactg gttccagcag      120

cttccaggag cagcccccaa actcctcatc tatgctaaca gcaatcggcc ctcaggggtc      180

cctgaccgat tctctggctc caagtctggc acctcagcct ccctggccat cactgggctc      240

caggctgagg atgaggctga ttattactgc cagtcctatg acagcagact gggtggttcg      300

gtattcggcg gagggaccaa ggtgaccgtc cta                                   333


<210> 2151
<211> 111
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      Light chain variable region ('LC') amino acid sequence"

<400> 2151
Ser Tyr Glu Leu Thr Gln Pro Pro Ser Val Ser Gly Ala Pro Gly Gln 
1               5                   10                  15      


Arg Val Thr Ile Ser Cys Thr Gly Ser Ser Ser Asn Ile Gly Arg Gly 
            20                  25                  30          


Tyr Asp Val His Trp Phe Gln Gln Leu Pro Gly Ala Ala Pro Lys Leu 
        35                  40                  45              


Leu Ile Tyr Ala Asn Ser Asn Arg Pro Ser Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Thr Gly Leu 
65                  70                  75                  80  


Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Gln Ser Tyr Asp Ser Arg 
                85                  90                  95      


Leu Gly Gly Ser Val Phe Gly Gly Gly Thr Lys Val Thr Val Leu 
            100                 105                 110     


<210> 2152
<211> 14
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L1 ('L1') amino acid sequence"

<400> 2152
Thr Gly Ser Ser Ser Asn Ile Gly Arg Gly Tyr Asp Val His 
1               5                   10                  


<210> 2153
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L2 ('L2') amino acid sequence"

<400> 2153
Ala Asn Ser Asn Arg Pro Ser 
1               5           


<210> 2154
<211> 11
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L3 ('L3') amino acid sequence"

<400> 2154
Gln Ser Tyr Asp Ser Arg Leu Gly Gly Ser Val 
1               5                   10      


<210> 2155
<211> 366
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      Heavy chain variable region ('HC') nucleic acid sequence"

<400> 2155
gaggtgcagc tggtggagtc tgggggaggc ctggtcaagc ctgggggggc cctgagactc       60

tcctgtgcag cctctggatt cagcttcagg agctatagca tgaactgggt ccgccaggct      120

ccagggaagg ggctggagtg ggtctcatcc attagtagta gtagtaatta cataaactac      180

gcagactcag tgaagggccg attcagcatc tccagagaca acgccaagaa ctcactgtat      240

ctgcaaatga acagcctgag agccgaggac acggctgtct attactgtgc gagagatttg      300

ttacccgtcg agcggggtcc cgcttttgat atctggggcc aagggacaat ggtcaccgtc      360

tcttca                                                                 366


<210> 2156
<211> 122
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      Heavy chain variable region ('HC') amino acid sequence"

<400> 2156
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ala Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ser Phe Arg Ser Tyr 
            20                  25                  30          


Ser Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ser Ile Ser Ser Ser Ser Asn Tyr Ile Asn Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Ser Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Leu Leu Pro Val Glu Arg Gly Pro Ala Phe Asp Ile Trp 
            100                 105                 110         


Gly Gln Gly Thr Met Val Thr Val Ser Ser 
        115                 120         


<210> 2157
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H1 ('H1') amino acid sequence"

<400> 2157
Phe Ser Phe Arg Ser Tyr Ser Met Asn 
1               5                   


<210> 2158
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H2 ('H2') amino acid sequence"

<400> 2158
Ser Ile Ser Ser Ser Ser Asn Tyr Ile Asn Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210> 2159
<211> 15
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H3 ('H3') amino acid sequence"

<400> 2159
Ala Arg Asp Leu Leu Pro Val Glu Arg Gly Pro Ala Phe Asp Ile 
1               5                   10                  15  


<210> 2160
<211> 333
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      Light chain variable region('LC') nucleic acid sequence"

<400> 2160
tcctatgagc tgacacagcc accctcagtg tctggggccc cagggcagag ggtcaccatc       60

tcctgcactg ggagcagctc caacatcggg gcaggttatg atgtacactg gttccagcag      120

cttccaggag cagcccccaa actcctcatc tatcgtaaca gcaatcggcc ctcaggggtc      180

cctgaccgat tctctggctc caagtctggc acctcagcct ccctggccat cactgggctc      240

caggctgagg atgaggctga ttattactgc cagtcctatg acagcagact gggtggttcg      300

aatttcggcg gagggaccaa ggtgaccgtc cta                                   333


<210> 2161
<211> 111
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      Light chain variable region ('LC') amino acid sequence"

<400> 2161
Ser Tyr Glu Leu Thr Gln Pro Pro Ser Val Ser Gly Ala Pro Gly Gln 
1               5                   10                  15      


Arg Val Thr Ile Ser Cys Thr Gly Ser Ser Ser Asn Ile Gly Ala Gly 
            20                  25                  30          


Tyr Asp Val His Trp Phe Gln Gln Leu Pro Gly Ala Ala Pro Lys Leu 
        35                  40                  45              


Leu Ile Tyr Arg Asn Ser Asn Arg Pro Ser Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Thr Gly Leu 
65                  70                  75                  80  


Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Gln Ser Tyr Asp Ser Arg 
                85                  90                  95      


Leu Gly Gly Ser Asn Phe Gly Gly Gly Thr Lys Val Thr Val Leu 
            100                 105                 110     


<210> 2162
<211> 14
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L1 ('L1') amino acid sequence"

<400> 2162
Thr Gly Ser Ser Ser Asn Ile Gly Ala Gly Tyr Asp Val His 
1               5                   10                  


<210> 2163
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L2 ('L2') amino acid sequence"

<400> 2163
Arg Asn Ser Asn Arg Pro Ser 
1               5           


<210> 2164
<211> 11
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L3 ('L3') amino acid sequence"

<400> 2164
Gln Ser Tyr Asp Ser Arg Leu Gly Gly Ser Asn 
1               5                   10      


<210> 2165
<211> 366
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      Heavy chain variable region ('HC') nucleic acid sequence"

<400> 2165
gaggtgcagc tggtggagtc tgggggaggc ctggtcaagc ctgggggggc cctgagactc       60

tcctgtgcag cctctggatt cagcttcagg agctatagca tgaactgggt ccgccaggct      120

ccagggaagg ggctggagtg ggtctcatcc attagtgcta gtagtaatta cataaactac      180

gcagactcag tgaagggccg attcagcatc tccagagaca acgccaagaa ctcactgtat      240

ctgcaaatga acagcctgag agccgaggac acggctgtct attactgtgc gagagatttg      300

ttacccgtcg agcggggtcc cgcttttgat atctggggcc aagggacaat ggtcaccgtc      360

tcttca                                                                 366


<210> 2166
<211> 122
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      Heavy chain variable region ('HC') amino acid sequence"

<400> 2166
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ala Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ser Phe Arg Ser Tyr 
            20                  25                  30          


Ser Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ser Ile Ser Ala Ser Ser Asn Tyr Ile Asn Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Ser Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Leu Leu Pro Val Glu Arg Gly Pro Ala Phe Asp Ile Trp 
            100                 105                 110         


Gly Gln Gly Thr Met Val Thr Val Ser Ser 
        115                 120         


<210> 2167
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H1 ('H1') amino acid sequence"

<400> 2167
Phe Ser Phe Arg Ser Tyr Ser Met Asn 
1               5                   


<210> 2168
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H2 ('H2') amino acid sequence"

<400> 2168
Ser Ile Ser Ala Ser Ser Asn Tyr Ile Asn Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210> 2169
<211> 15
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H3 ('H3') amino acid sequence"

<400> 2169
Ala Arg Asp Leu Leu Pro Val Glu Arg Gly Pro Ala Phe Asp Ile 
1               5                   10                  15  


<210> 2170
<211> 333
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      Light chain variable region('LC') nucleic acid sequence"

<400> 2170
tcctatgagc tgacacagcc accctcagtg tctggggccc cagggcagag ggtcaccatc       60

tcctgcactg ggagcagctc caacatcggg gcaggttatg atgtacactg gttccagcag      120

cttccaggag cagcccccaa actcctcatc tatgctaaca gcaatcggcc ctcaggggtc      180

cctgaccgat tctctggctc caagtctggc acctcagcct ccctggccat cactgggctc      240

caggctgagg atgaggctga ttattactgc cagtcctatg acagcagact gggtggttcg      300

gtattcggcg gagggaccaa ggtgaccgtc cta                                   333


<210> 2171
<211> 111
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      Light chain variable region ('LC') amino acid sequence"

<400> 2171
Ser Tyr Glu Leu Thr Gln Pro Pro Ser Val Ser Gly Ala Pro Gly Gln 
1               5                   10                  15      


Arg Val Thr Ile Ser Cys Thr Gly Ser Ser Ser Asn Ile Gly Ala Gly 
            20                  25                  30          


Tyr Asp Val His Trp Phe Gln Gln Leu Pro Gly Ala Ala Pro Lys Leu 
        35                  40                  45              


Leu Ile Tyr Ala Asn Ser Asn Arg Pro Ser Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Thr Gly Leu 
65                  70                  75                  80  


Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Gln Ser Tyr Asp Ser Arg 
                85                  90                  95      


Leu Gly Gly Ser Val Phe Gly Gly Gly Thr Lys Val Thr Val Leu 
            100                 105                 110     


<210> 2172
<211> 14
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L1 ('L1') amino acid sequence"

<400> 2172
Thr Gly Ser Ser Ser Asn Ile Gly Ala Gly Tyr Asp Val His 
1               5                   10                  


<210> 2173
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L2 ('L2') amino acid sequence"

<400> 2173
Ala Asn Ser Asn Arg Pro Ser 
1               5           


<210> 2174
<211> 11
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L3 ('L3') amino acid sequence"

<400> 2174
Gln Ser Tyr Asp Ser Arg Leu Gly Gly Ser Val 
1               5                   10      


<210> 2175
<211> 366
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      Heavy chain variable region ('HC') nucleic acid sequence"

<400> 2175
gaggtgcagc tggtggagtc tgggggaggc ctggtcaagc ctgggggggc cctgagactc       60

tcctgtgcag cctctggatt cagcttcagg agctatagca tgaactgggt ccgccaggct      120

ccagggaagg ggctggagtg ggtctcatcc attagtagta gtagtactta cataaactac      180

gcagactcag tgaagggccg attcagcatc tccagagaca acgccaagaa ctcactgtat      240

ctgcaaatga acagcctgag agccgaggac acggctgtct attactgtgc gagagatttg      300

agtcccgtcg agcggggtcc cgcttttgat atctggggcc aagggacaat ggtcaccgtc      360

tcttca                                                                 366


<210> 2176
<211> 122
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      Heavy chain variable region ('HC') amino acid sequence"

<400> 2176
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ala Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ser Phe Arg Ser Tyr 
            20                  25                  30          


Ser Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ser Ile Ser Ser Ser Ser Thr Tyr Ile Asn Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Ser Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Leu Ser Pro Val Glu Arg Gly Pro Ala Phe Asp Ile Trp 
            100                 105                 110         


Gly Gln Gly Thr Met Val Thr Val Ser Ser 
        115                 120         


<210> 2177
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H1 ('H1') amino acid sequence"

<400> 2177
Phe Ser Phe Arg Ser Tyr Ser Met Asn 
1               5                   


<210> 2178
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H2 ('H2') amino acid sequence"

<400> 2178
Ser Ile Ser Ser Ser Ser Thr Tyr Ile Asn Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210> 2179
<211> 15
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H3 ('H3') amino acid sequence"

<400> 2179
Ala Arg Asp Leu Ser Pro Val Glu Arg Gly Pro Ala Phe Asp Ile 
1               5                   10                  15  


<210> 2180
<211> 333
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      Light chain variable region('LC') nucleic acid sequence"

<400> 2180
tcctatgagc tgacacagcc accctcagtg tctggggccc cagggcagag ggtcaccatc       60

tcctgcactg ggagcagctc caacatcggg gcaggttatg atgtacactg gttccagcag      120

cttccaggag cagcccccaa actcctcatc tatgctaaca gcaatcggcc ctcaggggtc      180

cctgaccgat tctctggctc caagtctggc acctcagcct ccctggccat cactgggctc      240

caggctgagg atgaggctga ttattactgc cagtcctatg acagcagact gggtggttcg      300

gtattcggcg gagggaccaa ggtgaccgtc cta                                   333


<210> 2181
<211> 111
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      Light chain variable region ('LC') amino acid sequence"

<400> 2181
Ser Tyr Glu Leu Thr Gln Pro Pro Ser Val Ser Gly Ala Pro Gly Gln 
1               5                   10                  15      


Arg Val Thr Ile Ser Cys Thr Gly Ser Ser Ser Asn Ile Gly Ala Gly 
            20                  25                  30          


Tyr Asp Val His Trp Phe Gln Gln Leu Pro Gly Ala Ala Pro Lys Leu 
        35                  40                  45              


Leu Ile Tyr Ala Asn Ser Asn Arg Pro Ser Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Thr Gly Leu 
65                  70                  75                  80  


Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Gln Ser Tyr Asp Ser Arg 
                85                  90                  95      


Leu Gly Gly Ser Val Phe Gly Gly Gly Thr Lys Val Thr Val Leu 
            100                 105                 110     


<210> 2182
<211> 14
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L1 ('L1') amino acid sequence"

<400> 2182
Thr Gly Ser Ser Ser Asn Ile Gly Ala Gly Tyr Asp Val His 
1               5                   10                  


<210> 2183
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L2 ('L2') amino acid sequence"

<400> 2183
Ala Asn Ser Asn Arg Pro Ser 
1               5           


<210> 2184
<211> 11
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L3 ('L3') amino acid sequence"

<400> 2184
Gln Ser Tyr Asp Ser Arg Leu Gly Gly Ser Val 
1               5                   10      


<210> 2185
<211> 366
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      Heavy chain variable region ('HC') nucleic acid sequence"

<400> 2185
gaggtgcagc tggtggagtc tgggggaggc ctggtcaagc ctgggggggc cctgagactc       60

tcctgtgcag cctctggatt cagcttcagg agctatagca tgaactgggt ccgccaggct      120

ccagggaagg ggctggagtg ggtctcatcc attagtgcta gtagtaatta cataaactac      180

gcagactcag tgaagggccg attcagcatc tccagagaca acgccaagaa ctcactgtat      240

ctgcaaatga acagcctgag agccgaggac acggctgtct attactgtgc gagagatttg      300

ttacccgtcg agcggggtcc cgcttttgat atctggggcc aagggacaat ggtcaccgtc      360

tcttca                                                                 366


<210> 2186
<211> 122
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      Heavy chain variable region ('HC') amino acid sequence"

<400> 2186
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ala Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ser Phe Arg Ser Tyr 
            20                  25                  30          


Ser Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ser Ile Ser Ala Ser Ser Asn Tyr Ile Asn Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Ser Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Leu Leu Pro Val Glu Arg Gly Pro Ala Phe Asp Ile Trp 
            100                 105                 110         


Gly Gln Gly Thr Met Val Thr Val Ser Ser 
        115                 120         


<210> 2187
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H1 ('H1') amino acid sequence"

<400> 2187
Phe Ser Phe Arg Ser Tyr Ser Met Asn 
1               5                   


<210> 2188
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H2 ('H2') amino acid sequence"

<400> 2188
Ser Ile Ser Ala Ser Ser Asn Tyr Ile Asn Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210> 2189
<211> 15
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H3 ('H3') amino acid sequence"

<400> 2189
Ala Arg Asp Leu Leu Pro Val Glu Arg Gly Pro Ala Phe Asp Ile 
1               5                   10                  15  


<210> 2190
<211> 333
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      Light chain variable region('LC') nucleic acid sequence"

<400> 2190
tcctacgagc tgacacagcc accctcagtg tctggggccc cagggcagag ggtcactatc       60

tcctgcactg ggagcagctc caacatcggg aggggttatg atgtacactg gttccagcag      120

cttccaggag cagcccccaa actcctcatc tatgctaaca gcaatcggcc ctcaggggtc      180

cctgaccgat tctctggctc caagtctggc acctcagcct ccctggccat cactgggctc      240

caggctgagg atgaggctga ttattactgc cagtcctatg acagcagact gggtggttcg      300

gtattcggcg gagggaccaa ggtgaccgtc cta                                   333


<210> 2191
<211> 111
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      Light chain variable region ('LC') amino acid sequence"

<400> 2191
Ser Tyr Glu Leu Thr Gln Pro Pro Ser Val Ser Gly Ala Pro Gly Gln 
1               5                   10                  15      


Arg Val Thr Ile Ser Cys Thr Gly Ser Ser Ser Asn Ile Gly Arg Gly 
            20                  25                  30          


Tyr Asp Val His Trp Phe Gln Gln Leu Pro Gly Ala Ala Pro Lys Leu 
        35                  40                  45              


Leu Ile Tyr Ala Asn Ser Asn Arg Pro Ser Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Thr Gly Leu 
65                  70                  75                  80  


Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Gln Ser Tyr Asp Ser Arg 
                85                  90                  95      


Leu Gly Gly Ser Val Phe Gly Gly Gly Thr Lys Val Thr Val Leu 
            100                 105                 110     


<210> 2192
<211> 14
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L1 ('L1') amino acid sequence"

<400> 2192
Thr Gly Ser Ser Ser Asn Ile Gly Arg Gly Tyr Asp Val His 
1               5                   10                  


<210> 2193
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L2 ('L2') amino acid sequence"

<400> 2193
Ala Asn Ser Asn Arg Pro Ser 
1               5           


<210> 2194
<211> 11
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L3 ('L3') amino acid sequence"

<400> 2194
Gln Ser Tyr Asp Ser Arg Leu Gly Gly Ser Val 
1               5                   10      


<210> 2195
<211> 366
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      Heavy chain variable region ('HC') nucleic acid sequence"

<400> 2195
gaggtgcagc tggtggagtc tgggggaggc ctggtcaagc ctgggggggc cctgagactc       60

tcctgtgcag cctctggatt cagcttcagg agctatagca tgaactgggt ccgccaggct      120

ccagggaagg ggctggagtg ggtctcatcc attagtgcta gtagtaatta cataaactac      180

gcagactcag tgaagggccg attcagcatc tccagagaca acgccaagaa ctcactgtat      240

ctgcaaatga acagcctgag agccgaggac acggctgtct attactgtgc gagagatttg      300

ttacccgtcg agcggggtcc cgcttttgat atctggggcc aagggacaat ggtcaccgtc      360

tcttca                                                                 366


<210> 2196
<211> 122
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      Heavy chain variable region ('HC') amino acid sequence"

<400> 2196
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ala Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ser Phe Arg Ser Tyr 
            20                  25                  30          


Ser Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ser Ile Ser Ala Ser Ser Asn Tyr Ile Asn Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Ser Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Leu Leu Pro Val Glu Arg Gly Pro Ala Phe Asp Ile Trp 
            100                 105                 110         


Gly Gln Gly Thr Met Val Thr Val Ser Ser 
        115                 120         


<210> 2197
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H1 ('H1') amino acid sequence"

<400> 2197
Phe Ser Phe Arg Ser Tyr Ser Met Asn 
1               5                   


<210> 2198
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H2 ('H2') amino acid sequence"

<400> 2198
Ser Ile Ser Ala Ser Ser Asn Tyr Ile Asn Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210> 2199
<211> 15
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H3 ('H3') amino acid sequence"

<400> 2199
Ala Arg Asp Leu Leu Pro Val Glu Arg Gly Pro Ala Phe Asp Ile 
1               5                   10                  15  


<210> 2200
<211> 333
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      Light chain variable region('LC') nucleic acid sequence"

<400> 2200
tcctatgagc tgacacagcc accctcagtg tctggggccc cagggcagag ggtcaccatc       60

tcctgcactg ggagcagctc caacatcggg gcaggttatg atgtacactg gttccagcag      120

cttccaggag cagcccccaa actcctcatc tatcgtaaca gcaatcggcc ctcaggggtc      180

cctgaccgat tctctggctc caagtctggc acctcagcct ccctggccat cactgggctc      240

caggctgagg atgaggctga ttattactgc cagtcctatg acagcagact gggtggttcg      300

aatttcggcg gagggaccaa ggtgaccgtc cta                                   333


<210> 2201
<211> 111
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      Light chain variable region ('LC') amino acid sequence"

<400> 2201
Ser Tyr Glu Leu Thr Gln Pro Pro Ser Val Ser Gly Ala Pro Gly Gln 
1               5                   10                  15      


Arg Val Thr Ile Ser Cys Thr Gly Ser Ser Ser Asn Ile Gly Ala Gly 
            20                  25                  30          


Tyr Asp Val His Trp Phe Gln Gln Leu Pro Gly Ala Ala Pro Lys Leu 
        35                  40                  45              


Leu Ile Tyr Arg Asn Ser Asn Arg Pro Ser Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Thr Gly Leu 
65                  70                  75                  80  


Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Gln Ser Tyr Asp Ser Arg 
                85                  90                  95      


Leu Gly Gly Ser Asn Phe Gly Gly Gly Thr Lys Val Thr Val Leu 
            100                 105                 110     


<210> 2202
<211> 14
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L1 ('L1') amino acid sequence"

<400> 2202
Thr Gly Ser Ser Ser Asn Ile Gly Ala Gly Tyr Asp Val His 
1               5                   10                  


<210> 2203
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L2 ('L2') amino acid sequence"

<400> 2203
Arg Asn Ser Asn Arg Pro Ser 
1               5           


<210> 2204
<211> 11
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L3 ('L3') amino acid sequence"

<400> 2204
Gln Ser Tyr Asp Ser Arg Leu Gly Gly Ser Asn 
1               5                   10      


<210> 2205
<211> 366
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      Heavy chain variable region ('HC') nucleic acid sequence"

<400> 2205
gaggtgcagc tggtggagtc tgggggaggc ctggtcaagc ctgggggggc cctgagactc       60

tcctgtgcag cctctggatt cagcttcagg agctatagca tgaactgggt ccgccaggct      120

ccagggaagg ggctggagtg ggtctcatcc attagtagta gtagtactta cataaactac      180

gcagactcag tgaagggccg attcagcatc tccagagaca acgccaagaa ctcactgtat      240

ctgcaaatga acagcctgag agccgaggac acggctgtct attactgtgc gagagatttg      300

agtcccgtcg agcggggtcc cgcttttgat atctggggcc aagggacaat ggtcaccgtc      360

tcttca                                                                 366


<210> 2206
<211> 122
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      Heavy chain variable region ('HC') amino acid sequence"

<400> 2206
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ala Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ser Phe Arg Ser Tyr 
            20                  25                  30          


Ser Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ser Ile Ser Ser Ser Ser Thr Tyr Ile Asn Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Ser Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Leu Ser Pro Val Glu Arg Gly Pro Ala Phe Asp Ile Trp 
            100                 105                 110         


Gly Gln Gly Thr Met Val Thr Val Ser Ser 
        115                 120         


<210> 2207
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H1 ('H1') amino acid sequence"

<400> 2207
Phe Ser Phe Arg Ser Tyr Ser Met Asn 
1               5                   


<210> 2208
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H2 ('H2') amino acid sequence"

<400> 2208
Ser Ile Ser Ser Ser Ser Thr Tyr Ile Asn Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210> 2209
<211> 15
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H3 ('H3') amino acid sequence"

<400> 2209
Ala Arg Asp Leu Ser Pro Val Glu Arg Gly Pro Ala Phe Asp Ile 
1               5                   10                  15  


<210> 2210
<211> 333
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      Light chain variable region('LC') nucleic acid sequence"

<400> 2210
tcctacgagc tgacacagcc accctcagtg tctggggccc cagggcagag ggtcactatc       60

tcctgcactg ggagcagctc caacatcggg aggggttatg atgtacactg gttccagcag      120

cttccaggag cagcccccaa actcctcatc tatgctaaca gcaatcggcc ctcaggggtc      180

cctgaccgat tctctggctc caagtctggc acctcagcct ccctggccat cactgggctc      240

caggctgagg atgaggctga ttattactgc cagtcctatg acagcagact gggtggttcg      300

gtattcggcg gagggaccaa ggtgaccgtc cta                                   333


<210> 2211
<211> 111
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      Light chain variable region ('LC') amino acid sequence"

<400> 2211
Ser Tyr Glu Leu Thr Gln Pro Pro Ser Val Ser Gly Ala Pro Gly Gln 
1               5                   10                  15      


Arg Val Thr Ile Ser Cys Thr Gly Ser Ser Ser Asn Ile Gly Arg Gly 
            20                  25                  30          


Tyr Asp Val His Trp Phe Gln Gln Leu Pro Gly Ala Ala Pro Lys Leu 
        35                  40                  45              


Leu Ile Tyr Ala Asn Ser Asn Arg Pro Ser Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Thr Gly Leu 
65                  70                  75                  80  


Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Gln Ser Tyr Asp Ser Arg 
                85                  90                  95      


Leu Gly Gly Ser Val Phe Gly Gly Gly Thr Lys Val Thr Val Leu 
            100                 105                 110     


<210> 2212
<211> 14
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L1 ('L1') amino acid sequence"

<400> 2212
Thr Gly Ser Ser Ser Asn Ile Gly Arg Gly Tyr Asp Val His 
1               5                   10                  


<210> 2213
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L2 ('L2') amino acid sequence"

<400> 2213
Ala Asn Ser Asn Arg Pro Ser 
1               5           


<210> 2214
<211> 11
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L3 ('L3') amino acid sequence"

<400> 2214
Gln Ser Tyr Asp Ser Arg Leu Gly Gly Ser Val 
1               5                   10      


<210> 2215
<211> 366
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      Heavy chain variable region ('HC') nucleic acid sequence"

<400> 2215
gaggtgcagc tggtggagtc tgggggaggc ctggtcaagc ctgggggggc cctgagactc       60

tcctgtgcag cctctggatt cagcttcagg agctatagca tgaactgggt ccgccaggct      120

ccagggaagg ggctggagtg ggtctcatcc attagtagta gtagtactta cataaactac      180

gcagactcag tgaagggccg attcagcatc tccagagaca acgccaagaa ctcactgtat      240

ctgcaaatga acagcctgag agccgaggac acggctgtct attactgtgc gagagatttg      300

agtcccgtcg agcggggtcc cgcttttgat atctggggcc aagggacaat ggtcaccgtc      360

tcttca                                                                 366


<210> 2216
<211> 122
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      Heavy chain variable region ('HC') amino acid sequence"

<400> 2216
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ala Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ser Phe Arg Ser Tyr 
            20                  25                  30          


Ser Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ser Ile Ser Ser Ser Ser Thr Tyr Ile Asn Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Ser Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Leu Ser Pro Val Glu Arg Gly Pro Ala Phe Asp Ile Trp 
            100                 105                 110         


Gly Gln Gly Thr Met Val Thr Val Ser Ser 
        115                 120         


<210> 2217
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H1 ('H1') amino acid sequence"

<400> 2217
Phe Ser Phe Arg Ser Tyr Ser Met Asn 
1               5                   


<210> 2218
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H2 ('H2') amino acid sequence"

<400> 2218
Ser Ile Ser Ser Ser Ser Thr Tyr Ile Asn Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210> 2219
<211> 15
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H3 ('H3') amino acid sequence"

<400> 2219
Ala Arg Asp Leu Ser Pro Val Glu Arg Gly Pro Ala Phe Asp Ile 
1               5                   10                  15  


<210> 2220
<211> 333
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      Light chain variable region('LC') nucleic acid sequence"

<400> 2220
tcctatgagc tgacacagcc accctcagtg tctggggccc cagggcagag ggtcaccatc       60

tcctgcactg ggagcagctc caacatcggg gcaggttatg atgtacactg gttccagcag      120

cttccaggag cagcccccaa actcctcatc tatcgtaaca gcaatcggcc ctcaggggtc      180

cctgaccgat tctctggctc caagtctggc acctcagcct ccctggccat cactgggctc      240

caggctgagg atgaggctga ttattactgc cagtcctatg acagcagact gggtggttcg      300

aatttcggcg gagggaccaa ggtgaccgtc cta                                   333


<210> 2221
<211> 111
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      Light chain variable region ('LC') amino acid sequence"

<400> 2221
Ser Tyr Glu Leu Thr Gln Pro Pro Ser Val Ser Gly Ala Pro Gly Gln 
1               5                   10                  15      


Arg Val Thr Ile Ser Cys Thr Gly Ser Ser Ser Asn Ile Gly Ala Gly 
            20                  25                  30          


Tyr Asp Val His Trp Phe Gln Gln Leu Pro Gly Ala Ala Pro Lys Leu 
        35                  40                  45              


Leu Ile Tyr Arg Asn Ser Asn Arg Pro Ser Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Thr Gly Leu 
65                  70                  75                  80  


Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Gln Ser Tyr Asp Ser Arg 
                85                  90                  95      


Leu Gly Gly Ser Asn Phe Gly Gly Gly Thr Lys Val Thr Val Leu 
            100                 105                 110     


<210> 2222
<211> 14
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L1 ('L1') amino acid sequence"

<400> 2222
Thr Gly Ser Ser Ser Asn Ile Gly Ala Gly Tyr Asp Val His 
1               5                   10                  


<210> 2223
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L2 ('L2') amino acid sequence"

<400> 2223
Arg Asn Ser Asn Arg Pro Ser 
1               5           


<210> 2224
<211> 11
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L3 ('L3') amino acid sequence"

<400> 2224
Gln Ser Tyr Asp Ser Arg Leu Gly Gly Ser Asn 
1               5                   10      


