                               SEQUENCE LISTING

<110> ADIMAB LLC
 
<120> ANTI-RESPIRATORY SYNCYTIAL VIRUS ANTIBODIES, AND METHODS OF THEIR
      GENERATION AND USE

<130> 2009186-0217

<140>
<141>

<150> 62/411,500
<151> 2016-10-21

<160> 1858  

<170> PatentIn version 3.5

<210> 1
<211> 378
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region"

<400> 1
caggtgcagc tggtggagtc tggtcctgcg ctggtgaaac ccacacagac cctcacactg       60

acctgcagct tctccgggtt ctcactcacc actaggagaa tgtgtgtgag ctggatccgt      120

cagaccccag ggaaggccct ggagtggctt gcacgcattg attgggatga tgataaagac      180

tacagcacat ctctgaagac caggctcacc atctccaagg acacctccaa aaaccaggtg      240

gtccttacaa tgaccaacat ggaccctgtg gacacggcca cgtattactg tgcacggacc      300

cacatttatg atagtagtgg ttattatcta tactactttg actactgggg ccagggaacc      360

ctggtcaccg tctcttca                                                    378


<210> 2
<211> 126
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region"

<400> 2
Gln Val Gln Leu Val Glu Ser Gly Pro Ala Leu Val Lys Pro Thr Gln 
1               5                   10                  15      


Thr Leu Thr Leu Thr Cys Ser Phe Ser Gly Phe Ser Leu Thr Thr Arg 
            20                  25                  30          


Arg Met Cys Val Ser Trp Ile Arg Gln Thr Pro Gly Lys Ala Leu Glu 
        35                  40                  45              


Trp Leu Ala Arg Ile Asp Trp Asp Asp Asp Lys Asp Tyr Ser Thr Ser 
    50                  55                  60                  


Leu Lys Thr Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Val 
65                  70                  75                  80  


Val Leu Thr Met Thr Asn Met Asp Pro Val Asp Thr Ala Thr Tyr Tyr 
                85                  90                  95      


Cys Ala Arg Thr His Ile Tyr Asp Ser Ser Gly Tyr Tyr Leu Tyr Tyr 
            100                 105                 110         


Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125     


<210> 3
<211> 11
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H1"

<400> 3
Phe Ser Leu Thr Thr Arg Arg Met Cys Val Ser 
1               5                   10      


<210> 4
<211> 33
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H1"

<400> 4
ttctcactca ccactaggag aatgtgtgtg agc                                    33


<210> 5
<211> 16
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H2"

<400> 5
Arg Ile Asp Trp Asp Asp Asp Lys Asp Tyr Ser Thr Ser Leu Lys Thr 
1               5                   10                  15      


<210> 6
<211> 48
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H2"

<400> 6
cgcattgatt gggatgatga taaagactac agcacatctc tgaagacc                    48


<210> 7
<211> 18
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H3"

<400> 7
Ala Arg Thr His Ile Tyr Asp Ser Ser Gly Tyr Tyr Leu Tyr Tyr Phe 
1               5                   10                  15      


Asp Tyr 
        


<210> 8
<211> 54
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H3"

<400> 8
gcacggaccc acatttatga tagtagtggt tattatctat actactttga ctac             54


<210> 9
<211> 321
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region"

<400> 9
gatattgtgc tgacccagtc tccatcctcc ctgtctgcat ctataggaga cagagtcacc       60

atcacttgcc gggcaagtca gaccattgcc agctatttaa attggtatca gcagaaacca      120

gggaaagccc ctgaactcct gatctatgct gcaaccaatt tgcagagtgg ggtcccatca      180

aggttcagtg gcagtggatc tgggacagat ttcactctca ccatcagcag tctgcgacct      240

gaagattttg caagttacta ctgtcaacag agttacagta gtccctggac gttcggccaa      300

gggaccaaag tggatatcaa a                                                321


<210> 10
<211> 107
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region"

<400> 10
Asp Ile Val Leu Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Ile Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Thr Ile Ala Ser Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Glu Leu Leu Ile 
        35                  40                  45              


Tyr Ala Ala Thr Asn Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Arg Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Ser Tyr Tyr Cys Gln Gln Ser Tyr Ser Ser Pro Trp 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Asp Ile Lys 
            100                 105         


<210> 11
<211> 11
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L1"

<400> 11
Arg Ala Ser Gln Thr Ile Ala Ser Tyr Leu Asn 
1               5                   10      


<210> 12
<211> 33
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L1"

<400> 12
cgggcaagtc agaccattgc cagctattta aat                                    33


<210> 13
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L2"

<400> 13
Ala Ala Thr Asn Leu Gln Ser 
1               5           


<210> 14
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L2"

<400> 14
gctgcaacca atttgcagag t                                                 21


<210> 15
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L3"

<400> 15
Gln Gln Ser Tyr Ser Ser Pro Trp Thr 
1               5                   


<210> 16
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L3"

<400> 16
caacagagtt acagtagtcc ctggacg                                           27


<210> 17
<211> 372
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region"

<400> 17
gaggtgcagc tggtggagtc tggcccagga ctggtgaagc cttcggggac cctgtccctc       60

acctgcactg tctctggtga ctccatgagt gattactact ggagctggat ccggcagtcc      120

ccagggaggg gactggagtg gcttggatat atctattacg atgggagcac caactacaac      180

ccctccctca agggtcgagg caccatttca atagacacgt ccaagagcca gttctccctg      240

acgctgagct ctgtgaaggc tgcggacacg gccgtgtatt actgtgcgag agggaagtac      300

tatgatagag gtggttatta cctgttctac cttgactact ggggccaggg aatactggtc      360

accgtctcct ca                                                          372


<210> 18
<211> 124
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region"

<400> 18
Glu Val Gln Leu Val Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gly 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Asp Ser Met Ser Asp Tyr 
            20                  25                  30          


Tyr Trp Ser Trp Ile Arg Gln Ser Pro Gly Arg Gly Leu Glu Trp Leu 
        35                  40                  45              


Gly Tyr Ile Tyr Tyr Asp Gly Ser Thr Asn Tyr Asn Pro Ser Leu Lys 
    50                  55                  60                  


Gly Arg Gly Thr Ile Ser Ile Asp Thr Ser Lys Ser Gln Phe Ser Leu 
65                  70                  75                  80  


Thr Leu Ser Ser Val Lys Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Gly Lys Tyr Tyr Asp Arg Gly Gly Tyr Tyr Leu Phe Tyr Leu Asp 
            100                 105                 110         


Tyr Trp Gly Gln Gly Ile Leu Val Thr Val Ser Ser 
        115                 120                 


<210> 19
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H1"

<400> 19
Asp Ser Met Ser Asp Tyr Tyr Trp Ser 
1               5                   


<210> 20
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H1"

<400> 20
gactccatga gtgattacta ctggagc                                           27


<210> 21
<211> 16
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H2"

<400> 21
Tyr Ile Tyr Tyr Asp Gly Ser Thr Asn Tyr Asn Pro Ser Leu Lys Gly 
1               5                   10                  15      


<210> 22
<211> 48
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H2"

<400> 22
tatatctatt acgatgggag caccaactac aacccctccc tcaagggt                    48


<210> 23
<211> 18
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H3"

<400> 23
Ala Arg Gly Lys Tyr Tyr Asp Arg Gly Gly Tyr Tyr Leu Phe Tyr Leu 
1               5                   10                  15      


Asp Tyr 
        


<210> 24
<211> 54
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H3"

<400> 24
gcgagaggga agtactatga tagaggtggt tattacctgt tctaccttga ctac             54


<210> 25
<211> 324
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region"

<400> 25
gacatccggt tgacccagtc tccatcctcc ctgtctgcat ctgtgggaga cagagtcacc       60

atcacttgcc gggcaagtca gaccattgcc agctatgtaa actggtatca gcagaaacca      120

gggaaagccc ctaaactcct tatctatgct gcatccagtt tgcaagatgg ggttccatca      180

aggttcagtg gcagtggatc tgggacagat ttcgctctca ccatcagcag tctgcaacct      240

gaagattttg caatttactt ttgtcaacag agttacagta cccccatatt cactttcggc      300

cctgggacca aggtggaaat caaa                                             324


<210> 26
<211> 108
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region"

<400> 26
Asp Ile Arg Leu Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Thr Ile Ala Ser Tyr 
            20                  25                  30          


Val Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Ser Leu Gln Asp Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Ala Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Ile Tyr Phe Cys Gln Gln Ser Tyr Ser Thr Pro Ile 
                85                  90                  95      


Phe Thr Phe Gly Pro Gly Thr Lys Val Glu Ile Lys 
            100                 105             


<210> 27
<211> 11
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L1"

<400> 27
Arg Ala Ser Gln Thr Ile Ala Ser Tyr Val Asn 
1               5                   10      


<210> 28
<211> 33
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L1"

<400> 28
cgggcaagtc agaccattgc cagctatgta aac                                    33


<210> 29
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L2"

<400> 29
Ala Ala Ser Ser Leu Gln Asp 
1               5           


<210> 30
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L2"

<400> 30
gctgcatcca gtttgcaaga t                                                 21


<210> 31
<211> 10
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L3"

<400> 31
Gln Gln Ser Tyr Ser Thr Pro Ile Phe Thr 
1               5                   10  


<210> 32
<211> 30
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L3"

<400> 32
caacagagtt acagtacccc catattcact                                        30


<210> 33
<211> 369
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region"

<400> 33
gaggtgcagc tggtggagtc tgggggcgcc ttggtaaagc cgggggggtc ccttagactc       60

tcctgtgtag gcactggact cactttcact actgcctaca tgagctgggc ccgccaggct      120

ccagggaagg ggctggagtg ggttggtcgt attaagagca aaagtgatgg tgggacaaca      180

gactacccta cacccgtcaa aggcagattc accatctcaa gagatgaatc caaaaacacc      240

ctgtatctgc aaatgaacag cctgaaaatc gaggacacag ccgtctatta ttgtaccaca      300

gataggggga taacagctcg tcctatcttc gactcctggg gccagggaac cctggtcacc      360

gtctcctca                                                              369


<210> 34
<211> 123
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region"

<400> 34
Glu Val Gln Leu Val Glu Ser Gly Gly Ala Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Val Gly Thr Gly Leu Thr Phe Thr Thr Ala 
            20                  25                  30          


Tyr Met Ser Trp Ala Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Gly Arg Ile Lys Ser Lys Ser Asp Gly Gly Thr Thr Asp Tyr Pro Thr 
    50                  55                  60                  


Pro Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Glu Ser Lys Asn Thr 
65                  70                  75                  80  


Leu Tyr Leu Gln Met Asn Ser Leu Lys Ile Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Thr Thr Asp Arg Gly Ile Thr Ala Arg Pro Ile Phe Asp Ser 
            100                 105                 110         


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120             


<210> 35
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H1"

<400> 35
Leu Thr Phe Thr Thr Ala Tyr Met Ser 
1               5                   


<210> 36
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H1"

<400> 36
ctcactttca ctactgccta catgagc                                           27


<210> 37
<211> 19
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H2"

<400> 37
Arg Ile Lys Ser Lys Ser Asp Gly Gly Thr Thr Asp Tyr Pro Thr Pro 
1               5                   10                  15      


Val Lys Gly 
            


<210> 38
<211> 57
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H2"

<400> 38
cgtattaaga gcaaaagtga tggtgggaca acagactacc ctacacccgt caaaggc          57


<210> 39
<211> 14
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H3"

<400> 39
Thr Thr Asp Arg Gly Ile Thr Ala Arg Pro Ile Phe Asp Ser 
1               5                   10                  


<210> 40
<211> 42
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H3"

<400> 40
accacagata gggggataac agctcgtcct atcttcgact cc                          42


<210> 41
<211> 333
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region"

<400> 41
cagtctgtct tgacgcagcc gccctcagtg tctggggccc tagggcggag ggtcaccatc       60

tcctgcactg ggagcagctc caacatcggg gcgggttatg atgtacattg gtacaggcaa      120

cttccaggaa cagcccccaa actcctcatt tatggtaaca ccaaacggcc ctcaggggtc      180

cctgaccgat tctctggctc caagtatgcc acctcagcct ccctggccat cactgggctc      240

caggctgagg atgacgctga ttattactgc cagtcctatg acggcggcct gagtggttat      300

gtcttcggaa ctgggaccaa gctcaccgtc cta                                   333


<210> 42
<211> 111
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region"

<400> 42
Gln Ser Val Leu Thr Gln Pro Pro Ser Val Ser Gly Ala Leu Gly Arg 
1               5                   10                  15      


Arg Val Thr Ile Ser Cys Thr Gly Ser Ser Ser Asn Ile Gly Ala Gly 
            20                  25                  30          


Tyr Asp Val His Trp Tyr Arg Gln Leu Pro Gly Thr Ala Pro Lys Leu 
        35                  40                  45              


Leu Ile Tyr Gly Asn Thr Lys Arg Pro Ser Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Tyr Ala Thr Ser Ala Ser Leu Ala Ile Thr Gly Leu 
65                  70                  75                  80  


Gln Ala Glu Asp Asp Ala Asp Tyr Tyr Cys Gln Ser Tyr Asp Gly Gly 
                85                  90                  95      


Leu Ser Gly Tyr Val Phe Gly Thr Gly Thr Lys Leu Thr Val Leu 
            100                 105                 110     


<210> 43
<211> 14
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L1"

<400> 43
Thr Gly Ser Ser Ser Asn Ile Gly Ala Gly Tyr Asp Val His 
1               5                   10                  


<210> 44
<211> 42
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L1"

<400> 44
actgggagca gctccaacat cggggcgggt tatgatgtac at                          42


<210> 45
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L2"

<400> 45
Gly Asn Thr Lys Arg Pro Ser 
1               5           


<210> 46
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L2"

<400> 46
ggtaacacca aacggccctc a                                                 21


<210> 47
<211> 11
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L3"

<400> 47
Gln Ser Tyr Asp Gly Gly Leu Ser Gly Tyr Val 
1               5                   10      


<210> 48
<211> 33
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L3"

<400> 48
cagtcctatg acggcggcct gagtggttat gtc                                    33


<210> 49
<211> 390
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region"

<400> 49
caggtccagc ttgtacagtc tggggctgag gtgaagaagc ctgggtcctc ggtgaaggtc       60

tcctgcaagg cttctggagg caacgtcaac atctatggaa tcagttgggt gcgacaggcc      120

cctggacaag ggcttgagtg gatgggaggg atcatcccta tttatgatac aacaaagtac      180

gcacagaaat tccaggacag agtcacgatt accgcggaca aatccacgag tacagcctac      240

atggagttga gcagcctgag atctgaggac acggccgtat atttctgtgc gagagatctt      300

gattacgata ttttgactgg ttattccgta aactactact actacggtat ggacgtctgg      360

ggccaaggga ccacggtcac cgtctcctca                                       390


<210> 50
<211> 130
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region"

<400> 50
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Asn Val Asn Ile Tyr 
            20                  25                  30          


Gly Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Gly Ile Ile Pro Ile Tyr Asp Thr Thr Lys Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Asp Arg Val Thr Ile Thr Ala Asp Lys Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Phe Cys 
                85                  90                  95      


Ala Arg Asp Leu Asp Tyr Asp Ile Leu Thr Gly Tyr Ser Val Asn Tyr 
            100                 105                 110         


Tyr Tyr Tyr Gly Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val 
        115                 120                 125             


Ser Ser 
    130 


<210> 51
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H1"

<400> 51
Gly Asn Val Asn Ile Tyr Gly Ile Ser 
1               5                   


<210> 52
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H1"

<400> 52
ggcaacgtca acatctatgg aatcagt                                           27


<210> 53
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H2"

<400> 53
Gly Ile Ile Pro Ile Tyr Asp Thr Thr Lys Tyr Ala Gln Lys Phe Gln 
1               5                   10                  15      


Asp 
    


<210> 54
<211> 51
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H2"

<400> 54
gggatcatcc ctatttatga tacaacaaag tacgcacaga aattccagga c                51


<210> 55
<211> 23
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H3"

<400> 55
Ala Arg Asp Leu Asp Tyr Asp Ile Leu Thr Gly Tyr Ser Val Asn Tyr 
1               5                   10                  15      


Tyr Tyr Tyr Gly Met Asp Val 
            20              


<210> 56
<211> 69
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H3"

<400> 56
gcgagagatc ttgattacga tattttgact ggttattccg taaactacta ctactacggt       60

atggacgtc                                                               69


<210> 57
<211> 333
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region"

<400> 57
cagtctgtcc tgacgcagcc gccctcagtg tctggggccc cagggcagag ggtcaccatc       60

tcctgcactg ggagcagctc caacatcggg gcaggttatg atgtacactg gtaccagcag      120

cttccaggaa cagcccccaa actcctcatc tatggtaaca tcaatcggcc ctcaggggtc      180

cctgaccgat tctctggctc caagtctggc acctcagcct ccctggccat cactgggctc      240

caggctgagg atgaggctga ttattactgc cagtcctgtg acagcagcct aagtggttgg      300

gtgttcggcg gagggaccaa gctgaccatc cta                                   333


<210> 58
<211> 111
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region"

<400> 58
Gln Ser Val Leu Thr Gln Pro Pro Ser Val Ser Gly Ala Pro Gly Gln 
1               5                   10                  15      


Arg Val Thr Ile Ser Cys Thr Gly Ser Ser Ser Asn Ile Gly Ala Gly 
            20                  25                  30          


Tyr Asp Val His Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu 
        35                  40                  45              


Leu Ile Tyr Gly Asn Ile Asn Arg Pro Ser Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Thr Gly Leu 
65                  70                  75                  80  


Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Gln Ser Cys Asp Ser Ser 
                85                  90                  95      


Leu Ser Gly Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Ile Leu 
            100                 105                 110     


<210> 59
<211> 14
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L1"

<400> 59
Thr Gly Ser Ser Ser Asn Ile Gly Ala Gly Tyr Asp Val His 
1               5                   10                  


<210> 60
<211> 42
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L1"

<400> 60
actgggagca gctccaacat cggggcaggt tatgatgtac ac                          42


<210> 61
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L2"

<400> 61
Gly Asn Ile Asn Arg Pro Ser 
1               5           


<210> 62
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L2"

<400> 62
ggtaacatca atcggccctc a                                                 21


<210> 63
<211> 11
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L3"

<400> 63
Gln Ser Cys Asp Ser Ser Leu Ser Gly Trp Val 
1               5                   10      


<210> 64
<211> 33
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L3"

<400> 64
cagtcctgtg acagcagcct aagtggttgg gtg                                    33


<210> 65
<211> 375
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region"

<400> 65
caggtccagc ttgtacagtc tggggctgaa gtgaagaggc ctgggtcctc ggtgaaggtc       60

tcctgcaagg cttctggagg caccttcagc agctttgcta tcaactgggt gcgacaggcc      120

cctggacaag ggcttgagtg gatgggaggg ctcatcccta tctttggtac accaaacaac      180

gcacagaagt tccagggcag agtcacgatt accgcggacg aatccacgag cacagcctac      240

atggagctga gcagcctgag atctgaggac acggccgtct attactgtgc ctcattacga      300

tattttgact ggcaacctgg ggggtcctac tggttcgacc cctggggcca gggaaccctg      360

gtcaccgtct cctca                                                       375


<210> 66
<211> 125
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region"

<400> 66
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Arg Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Ser Phe 
            20                  25                  30          


Ala Ile Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Gly Leu Ile Pro Ile Phe Gly Thr Pro Asn Asn Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ser Leu Arg Tyr Phe Asp Trp Gln Pro Gly Gly Ser Tyr Trp Phe 
            100                 105                 110         


Asp Pro Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125 


<210> 67
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H1"

<400> 67
Gly Thr Phe Ser Ser Phe Ala Ile Asn 
1               5                   


<210> 68
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H1"

<400> 68
ggcaccttca gcagctttgc tatcaac                                           27


<210> 69
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H2"

<400> 69
Gly Leu Ile Pro Ile Phe Gly Thr Pro Asn Asn Ala Gln Lys Phe Gln 
1               5                   10                  15      


Gly 
    


<210> 70
<211> 51
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H2"

<400> 70
gggctcatcc ctatctttgg tacaccaaac aacgcacaga agttccaggg c                51


<210> 71
<211> 18
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H3"

<400> 71
Ala Ser Leu Arg Tyr Phe Asp Trp Gln Pro Gly Gly Ser Tyr Trp Phe 
1               5                   10                  15      


Asp Pro 
        


<210> 72
<211> 54
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H3"

<400> 72
gcctcattac gatattttga ctggcaacct ggggggtcct actggttcga cccc             54


<210> 73
<211> 330
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region"

<400> 73
cagcctgggc tgactcagcc accctcagtg tcagtggccc caggaaagac ggccaggatt       60

gcctgtgggg gagacaacat tggaactaaa ggagtgcact ggtaccagca gaagccaggc      120

caggcccctg tgctggtcat ctattatgat agcgaccggc cctcagggat ccctgagcga      180

ttctctggtt ccaactctgg gaacacggcc accctgacca tcagcggggt cgaagccggg      240

gatgaggccg actactactg tcaggtttgg gatactattg atgatcataa ggatggacta      300

ttcggcggag ggaccaagct caccgtccta                                       330


<210> 74
<211> 110
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region"

<400> 74
Gln Pro Gly Leu Thr Gln Pro Pro Ser Val Ser Val Ala Pro Gly Lys 
1               5                   10                  15      


Thr Ala Arg Ile Ala Cys Gly Gly Asp Asn Ile Gly Thr Lys Gly Val 
            20                  25                  30          


His Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Val Leu Val Ile Tyr 
        35                  40                  45              


Tyr Asp Ser Asp Arg Pro Ser Gly Ile Pro Glu Arg Phe Ser Gly Ser 
    50                  55                  60                  


Asn Ser Gly Asn Thr Ala Thr Leu Thr Ile Ser Gly Val Glu Ala Gly 
65                  70                  75                  80  


Asp Glu Ala Asp Tyr Tyr Cys Gln Val Trp Asp Thr Ile Asp Asp His 
                85                  90                  95      


Lys Asp Gly Leu Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 110 


<210> 75
<211> 11
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L1"

<400> 75
Gly Gly Asp Asn Ile Gly Thr Lys Gly Val His 
1               5                   10      


<210> 76
<211> 33
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L1"

<400> 76
gggggagaca acattggaac taaaggagtg cac                                    33


<210> 77
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L2"

<400> 77
Tyr Asp Ser Asp Arg Pro Ser 
1               5           


<210> 78
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L2"

<400> 78
tatgatagcg accggccctc a                                                 21


<210> 79
<211> 13
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L3"

<400> 79
Gln Val Trp Asp Thr Ile Asp Asp His Lys Asp Gly Leu 
1               5                   10              


<210> 80
<211> 39
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L3"

<400> 80
caggtttggg atactattga tgatcataag gatggacta                              39


<210> 81
<211> 375
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region"

<400> 81
caggtccagc ttgtgcagtc tggaggtgag gtgaagaagc ctggcgcctc agtgaaggtc       60

tcctgcaagg cttctggtta cacctttacc acctatggaa tcagctgggt gcgacaggcc      120

cctggacatg ggcttgagtg gctgggatgg atcagcccta agaatggcaa cacaaagtat      180

gcacagaagg tccagggcag agtcaccatg accatagacc caaccacgag tacagcctac      240

atggaactga ggagcctgag atcagacgac acggccatgt attactgtgc gagagactat      300

attgtagcaa tagtggctgc tctcccccac ggtatggacg tctggggcca agggaccctg      360

gtcactgtct cctca                                                       375


<210> 82
<211> 125
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region"

<400> 82
Gln Val Gln Leu Val Gln Ser Gly Gly Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Thr Tyr 
            20                  25                  30          


Gly Ile Ser Trp Val Arg Gln Ala Pro Gly His Gly Leu Glu Trp Leu 
        35                  40                  45              


Gly Trp Ile Ser Pro Lys Asn Gly Asn Thr Lys Tyr Ala Gln Lys Val 
    50                  55                  60                  


Gln Gly Arg Val Thr Met Thr Ile Asp Pro Thr Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Arg Ser Leu Arg Ser Asp Asp Thr Ala Met Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Tyr Ile Val Ala Ile Val Ala Ala Leu Pro His Gly Met 
            100                 105                 110         


Asp Val Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125 


<210> 83
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H1"

<400> 83
Tyr Thr Phe Thr Thr Tyr Gly Ile Ser 
1               5                   


<210> 84
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H1"

<400> 84
tacaccttta ccacctatgg aatcagc                                           27


<210> 85
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H2"

<400> 85
Trp Ile Ser Pro Lys Asn Gly Asn Thr Lys Tyr Ala Gln Lys Val Gln 
1               5                   10                  15      


Gly 
    


<210> 86
<211> 51
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H2"

<400> 86
tggatcagcc ctaagaatgg caacacaaag tatgcacaga aggtccaggg c                51


<210> 87
<211> 18
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H3"

<400> 87
Ala Arg Asp Tyr Ile Val Ala Ile Val Ala Ala Leu Pro His Gly Met 
1               5                   10                  15      


Asp Val 
        


<210> 88
<211> 54
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H3"

<400> 88
gcgagagact atattgtagc aatagtggct gctctccccc acggtatgga cgtc             54


<210> 89
<211> 318
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region"

<400> 89
cagtctgtct tgacgcagcc gccctccctg tccgtgtccc caggacagac agccagcatc       60

tcctgctctg gggatcagtt ggggaataaa tatgtttgtt ggtatcagca gaagccaggc      120

cagtcccctg ttctggtcat ctatcaagat tccaggcggc cctcaggggt ccctgagcga      180

ttctctggct ccaactccgg gaacacagcc actctgaccg tcggcgggac ccagcctatg      240

gatgaggctg actattactg tcaggcgtgg gacagcagca ttcgggtatt cggcggaggg      300

accaaggtga ccgtccta                                                    318


<210> 90
<211> 106
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region"

<400> 90
Gln Ser Val Leu Thr Gln Pro Pro Ser Leu Ser Val Ser Pro Gly Gln 
1               5                   10                  15      


Thr Ala Ser Ile Ser Cys Ser Gly Asp Gln Leu Gly Asn Lys Tyr Val 
            20                  25                  30          


Cys Trp Tyr Gln Gln Lys Pro Gly Gln Ser Pro Val Leu Val Ile Tyr 
        35                  40                  45              


Gln Asp Ser Arg Arg Pro Ser Gly Val Pro Glu Arg Phe Ser Gly Ser 
    50                  55                  60                  


Asn Ser Gly Asn Thr Ala Thr Leu Thr Val Gly Gly Thr Gln Pro Met 
65                  70                  75                  80  


Asp Glu Ala Asp Tyr Tyr Cys Gln Ala Trp Asp Ser Ser Ile Arg Val 
                85                  90                  95      


Phe Gly Gly Gly Thr Lys Val Thr Val Leu 
            100                 105     


<210> 91
<211> 11
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L1"

<400> 91
Ser Gly Asp Gln Leu Gly Asn Lys Tyr Val Cys 
1               5                   10      


<210> 92
<211> 33
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L1"

<400> 92
tctggggatc agttggggaa taaatatgtt tgt                                    33


<210> 93
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L2"

<400> 93
Gln Asp Ser Arg Arg Pro Ser 
1               5           


<210> 94
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L2"

<400> 94
caagattcca ggcggccctc a                                                 21


<210> 95
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L3"

<400> 95
Gln Ala Trp Asp Ser Ser Ile Arg Val 
1               5                   


<210> 96
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L3"

<400> 96
caggcgtggg acagcagcat tcgggta                                           27


<210> 97
<211> 375
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region"

<400> 97
caggtccagc ttgtacagtc tggggctgag gtgaagaagc ctgggtcctc ggtgaaggtc       60

tcctgcaagg cctctggagg ctccttgagc acctatggga tccactgggt gcgacaggcc      120

cctggccaag gccttgagtg ggtgggaggg gtcatgactg tctatggcaa aacaacctac      180

ggacagaact tccagggcag agtcaccatt gccgtggaca gatcgaccaa cacagcctac      240

atggaactga gcagcctaac atctgacgac acgggtactt attactgtgc gacagactcc      300

tactatgttt ggactggttc ttatcccccc ccctttgacc tctggggcca gggaaccctg      360

gtcaccgtct cctca                                                       375


<210> 98
<211> 125
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region"

<400> 98
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Ser Leu Ser Thr Tyr 
            20                  25                  30          


Gly Ile His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Val 
        35                  40                  45              


Gly Gly Val Met Thr Val Tyr Gly Lys Thr Thr Tyr Gly Gln Asn Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Ala Val Asp Arg Ser Thr Asn Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Thr Ser Asp Asp Thr Gly Thr Tyr Tyr Cys 
                85                  90                  95      


Ala Thr Asp Ser Tyr Tyr Val Trp Thr Gly Ser Tyr Pro Pro Pro Phe 
            100                 105                 110         


Asp Leu Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125 


<210> 99
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H1"

<400> 99
Gly Ser Leu Ser Thr Tyr Gly Ile His 
1               5                   


<210> 100
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H1"

<400> 100
ggctccttga gcacctatgg gatccac                                           27


<210> 101
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H2"

<400> 101
Gly Val Met Thr Val Tyr Gly Lys Thr Thr Tyr Gly Gln Asn Phe Gln 
1               5                   10                  15      


Gly 
    


<210> 102
<211> 51
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H2"

<400> 102
ggggtcatga ctgtctatgg caaaacaacc tacggacaga acttccaggg c                51


<210> 103
<211> 18
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H3"

<400> 103
Ala Thr Asp Ser Tyr Tyr Val Trp Thr Gly Ser Tyr Pro Pro Pro Phe 
1               5                   10                  15      


Asp Leu 
        


<210> 104
<211> 54
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H3"

<400> 104
gcgacagact cctactatgt ttggactggt tcttatcccc ccccctttga cctc             54


<210> 105
<211> 324
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region"

<400> 105
gaaattgtgt tgacccagac tccaggcacc cagtctttgt ctccagggca aagtgccacc       60

ctctcctgca gggccagtca cagtgtcggc aacgactact tggcctggta tcagcagaag      120

cctggccagt ctccccggct cctcattcac ggtgcataca ggagggactc tggcatccca      180

gacaggttca ttggcagtgg gtctgggaca gacttcactc tcaccatcga cagtctggag      240

cctgacgatt gtgcagtata ttactgtcag cagtatggga gctggcctct cactttcggc      300

ggagggacca aagtggatat caaa                                             324


<210> 106
<211> 108
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region"

<400> 106
Glu Ile Val Leu Thr Gln Thr Pro Gly Thr Gln Ser Leu Ser Pro Gly 
1               5                   10                  15      


Gln Ser Ala Thr Leu Ser Cys Arg Ala Ser His Ser Val Gly Asn Asp 
            20                  25                  30          


Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ser Pro Arg Leu Leu 
        35                  40                  45              


Ile His Gly Ala Tyr Arg Arg Asp Ser Gly Ile Pro Asp Arg Phe Ile 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Asp Ser Leu Glu 
65                  70                  75                  80  


Pro Asp Asp Cys Ala Val Tyr Tyr Cys Gln Gln Tyr Gly Ser Trp Pro 
                85                  90                  95      


Leu Thr Phe Gly Gly Gly Thr Lys Val Asp Ile Lys 
            100                 105             


<210> 107
<211> 12
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L1"

<400> 107
Arg Ala Ser His Ser Val Gly Asn Asp Tyr Leu Ala 
1               5                   10          


<210> 108
<211> 36
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L1"

<400> 108
agggccagtc acagtgtcgg caacgactac ttggcc                                 36


<210> 109
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L2"

<400> 109
Gly Ala Tyr Arg Arg Asp Ser 
1               5           


<210> 110
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L2"

<400> 110
ggtgcataca ggagggactc t                                                 21


<210> 111
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L3"

<400> 111
Gln Gln Tyr Gly Ser Trp Pro Leu Thr 
1               5                   


<210> 112
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L3"

<400> 112
cagcagtatg ggagctggcc tctcact                                           27


<210> 113
<211> 366
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region"

<400> 113
gaggtgcagc tggtggagtc tgggggaggc gtggtccagc ctgggaggtc cctgagactc       60

tcctgtgtta cctctggatt catcttcagc aattatgcta tgcactgggt ccgccaggct      120

ccaggcaagg ggctggagtg ggtggcagtt atatcctttg atgcagacaa tgaatattat      180

gcagagtccg tgaagggccg attcaccatc tccagagaca attccaagaa cacgatgtat      240

ctgcaaatga acagcctgag agccggggac acagctctct attactgtgc gagagatcct      300

ctgggtatag gagtgaaggg ctacgttgac ttctggggcc agggaaccct ggtcaccgtc      360

tcctca                                                                 366


<210> 114
<211> 122
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region"

<400> 114
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Val Thr Ser Gly Phe Ile Phe Ser Asn Tyr 
            20                  25                  30          


Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Val Ile Ser Phe Asp Ala Asp Asn Glu Tyr Tyr Ala Glu Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Met Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Gly Asp Thr Ala Leu Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Pro Leu Gly Ile Gly Val Lys Gly Tyr Val Asp Phe Trp 
            100                 105                 110         


Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120         


<210> 115
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H1"

<400> 115
Phe Ile Phe Ser Asn Tyr Ala Met His 
1               5                   


<210> 116
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H1"

<400> 116
ttcatcttca gcaattatgc tatgcac                                           27


<210> 117
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H2"

<400> 117
Val Ile Ser Phe Asp Ala Asp Asn Glu Tyr Tyr Ala Glu Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210> 118
<211> 51
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H2"

<400> 118
gttatatcct ttgatgcaga caatgaatat tatgcagagt ccgtgaaggg c                51


<210> 119
<211> 15
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H3"

<400> 119
Ala Arg Asp Pro Leu Gly Ile Gly Val Lys Gly Tyr Val Asp Phe 
1               5                   10                  15  


<210> 120
<211> 45
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H3"

<400> 120
gcgagagatc ctctgggtat aggagtgaag ggctacgttg acttc                       45


<210> 121
<211> 324
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region"

<400> 121
tcctctgagc tgagtcagcc accctcagtg tcagtggccc caggagagac ggccaggatt       60

acttgtgggg gagacaactt tggaagtgac ggtctgcact ggtaccagca gaagccaggc      120

caggcccctg tgttggtcat ctattatgat agcgaccggc cctcagggat ccctgagcga      180

ttctccggct ccatctctgg gaacacggcc accttgacca tcagcagggt cgaagccggg      240

gatgaggccg actatttctg tcaggtgtgg gatagtatta gtgatcatct ggtattcggc      300

ggggggacca aggtgaccgt ccta                                             324


<210> 122
<211> 108
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region"

<400> 122
Ser Ser Glu Leu Ser Gln Pro Pro Ser Val Ser Val Ala Pro Gly Glu 
1               5                   10                  15      


Thr Ala Arg Ile Thr Cys Gly Gly Asp Asn Phe Gly Ser Asp Gly Leu 
            20                  25                  30          


His Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Val Leu Val Ile Tyr 
        35                  40                  45              


Tyr Asp Ser Asp Arg Pro Ser Gly Ile Pro Glu Arg Phe Ser Gly Ser 
    50                  55                  60                  


Ile Ser Gly Asn Thr Ala Thr Leu Thr Ile Ser Arg Val Glu Ala Gly 
65                  70                  75                  80  


Asp Glu Ala Asp Tyr Phe Cys Gln Val Trp Asp Ser Ile Ser Asp His 
                85                  90                  95      


Leu Val Phe Gly Gly Gly Thr Lys Val Thr Val Leu 
            100                 105             


<210> 123
<211> 11
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L1"

<400> 123
Gly Gly Asp Asn Phe Gly Ser Asp Gly Leu His 
1               5                   10      


<210> 124
<211> 33
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L1"

<400> 124
gggggagaca actttggaag tgacggtctg cac                                    33


<210> 125
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L2"

<400> 125
Tyr Asp Ser Asp Arg Pro Ser 
1               5           


<210> 126
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L2"

<400> 126
tatgatagcg accggccctc a                                                 21


<210> 127
<211> 11
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L3"

<400> 127
Gln Val Trp Asp Ser Ile Ser Asp His Leu Val 
1               5                   10      


<210> 128
<211> 33
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L3"

<400> 128
caggtgtggg atagtattag tgatcatctg gta                                    33


<210> 129
<211> 372
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region"

<400> 129
caggtccagc ttgtgcagtc tggggctgag gtgaagaagc ctgggtcctc ggtgaaggtc       60

tcctgcaagg cttctggagg caccttcagc agttatgcta tcaactgggt gcgacaggcc      120

cctggacaag ggcttgagtg gatgggaggg atcatccctg cctttggtac aacaatctac      180

gcacagaggt tccaggacag agtcacgatt accgcggaca aatccacgag cacagcctac      240

atggagctga ggagcctgag atctgaggac acggccgtgt attactgtgc gaggtcacca      300

cccttttgga gtgactatag ccgtgggtgg ttcgacccct ggggccaggg aaccctggtc      360

accgtctcct ca                                                          372


<210> 130
<211> 124
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region"

<400> 130
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Ile Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Gly Ile Ile Pro Ala Phe Gly Thr Thr Ile Tyr Ala Gln Arg Phe 
    50                  55                  60                  


Gln Asp Arg Val Thr Ile Thr Ala Asp Lys Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Arg Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ser Pro Pro Phe Trp Ser Asp Tyr Ser Arg Gly Trp Phe Asp 
            100                 105                 110         


Pro Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 


<210> 131
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H1"

<400> 131
Gly Thr Phe Ser Ser Tyr Ala Ile Asn 
1               5                   


<210> 132
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H1"

<400> 132
ggcaccttca gcagttatgc tatcaac                                           27


<210> 133
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H2"

<400> 133
Gly Ile Ile Pro Ala Phe Gly Thr Thr Ile Tyr Ala Gln Arg Phe Gln 
1               5                   10                  15      


Asp 
    


<210> 134
<211> 51
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H2"

<400> 134
gggatcatcc ctgcctttgg tacaacaatc tacgcacaga ggttccagga c                51


<210> 135
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H3"

<400> 135
Ala Arg Ser Pro Pro Phe Trp Ser Asp Tyr Ser Arg Gly Trp Phe Asp 
1               5                   10                  15      


Pro 
    


<210> 136
<211> 51
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H3"

<400> 136
gcgaggtcac cacccttttg gagtgactat agccgtgggt ggttcgaccc c                51


<210> 137
<211> 321
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region"

<400> 137
gaaacgacac tcacgcagtc tccatccgcc ctgtctgcat ctgtaggaga cagagtcacc       60

atcacttgcc gggcaagtca gaccattagc ggctatttaa attggtatca gcagaaacca      120

gggaaagccc ctaagctcct gatctatgct gcatccagtt tgcaaagtgg ggtcccgtcg      180

agattcagtg gcagtagcgc tgggacagat ttcactctct ccatcagcaa tctacaacct      240

gaagattttg caacttacta ctgtcaacag agttacacta ccccgtggac gttcggccaa      300

gggaccaagg tggaaatcaa a                                                321


<210> 138
<211> 107
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region"

<400> 138
Glu Thr Thr Leu Thr Gln Ser Pro Ser Ala Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Thr Ile Ser Gly Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Ser Ala Gly Thr Asp Phe Thr Leu Ser Ile Ser Asn Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Tyr Thr Thr Pro Trp 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210> 139
<211> 11
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L1"

<400> 139
Arg Ala Ser Gln Thr Ile Ser Gly Tyr Leu Asn 
1               5                   10      


<210> 140
<211> 33
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L1"

<400> 140
cgggcaagtc agaccattag cggctattta aat                                    33


<210> 141
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L2"

<400> 141
Ala Ala Ser Ser Leu Gln Ser 
1               5           


<210> 142
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L2"

<400> 142
gctgcatcca gtttgcaaag t                                                 21


<210> 143
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L3"

<400> 143
Gln Gln Ser Tyr Thr Thr Pro Trp Thr 
1               5                   


<210> 144
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L3"

<400> 144
caacagagtt acactacccc gtggacg                                           27


<210> 145
<211> 354
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region"

<400> 145
caggtccagc tggtgcagtc tggagcagag gtgaaaaagc ccggagactc tctgaagatc       60

tcctgtaaga atgctggaca cacctctaga atctactgga tcgcctgggt gcgccagatg      120

cccgcgaaag gcctggagta catgggcatc atctttcctg gtgactctga taccagatac      180

agtccgtcct tccgaggcca ggtcaccatc tcagccgaca ggtccatcag aactgcctac      240

ctgcagttga gcagcctgaa ggcctcggac accggcattt attactgtgc gacacagggg      300

cttgaggggg cttttgacta ctggggccag ggaaccctgg tcaccgtctc ctca            354


<210> 146
<211> 118
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region"

<400> 146
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Asp 
1               5                   10                  15      


Ser Leu Lys Ile Ser Cys Lys Asn Ala Gly His Thr Ser Arg Ile Tyr 
            20                  25                  30          


Trp Ile Ala Trp Val Arg Gln Met Pro Ala Lys Gly Leu Glu Tyr Met 
        35                  40                  45              


Gly Ile Ile Phe Pro Gly Asp Ser Asp Thr Arg Tyr Ser Pro Ser Phe 
    50                  55                  60                  


Arg Gly Gln Val Thr Ile Ser Ala Asp Arg Ser Ile Arg Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Leu Ser Ser Leu Lys Ala Ser Asp Thr Gly Ile Tyr Tyr Cys 
                85                  90                  95      


Ala Thr Gln Gly Leu Glu Gly Ala Phe Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser 
        115             


<210> 147
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H1"

<400> 147
His Thr Ser Arg Ile Tyr Trp Ile Ala 
1               5                   


<210> 148
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H1"

<400> 148
cacacctcta gaatctactg gatcgcc                                           27


<210> 149
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H2"

<400> 149
Ile Ile Phe Pro Gly Asp Ser Asp Thr Arg Tyr Ser Pro Ser Phe Arg 
1               5                   10                  15      


Gly 
    


<210> 150
<211> 51
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H2"

<400> 150
atcatctttc ctggtgactc tgataccaga tacagtccgt ccttccgagg c                51


<210> 151
<211> 11
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H3"

<400> 151
Ala Thr Gln Gly Leu Glu Gly Ala Phe Asp Tyr 
1               5                   10      


<210> 152
<211> 33
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H3"

<400> 152
gcgacacagg ggcttgaggg ggcttttgac tac                                    33


<210> 153
<211> 324
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region"

<400> 153
gacatccggt tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga cagagtcacc       60

atcacttgcc aggcgagtca ggacattagc aaccagttaa attggtatca gcagaaacca      120

gggacagccc ctaagctcct catctacgat gcatcctttt tgcaaacagg ggtcccatca      180

aggttcagtg gaagtggatc tgggacacat tttactttca ccatcaccag cctgcagcct      240

gaagattttg caacatattt ctgtcagcat tatgatagtt tccccatatt cactttcggc      300

cctgggacca agctggagat caaa                                             324


<210> 154
<211> 108
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region"

<400> 154
Asp Ile Arg Leu Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Gln Ala Ser Gln Asp Ile Ser Asn Gln 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Thr Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Asp Ala Ser Phe Leu Gln Thr Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr His Phe Thr Phe Thr Ile Thr Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Phe Cys Gln His Tyr Asp Ser Phe Pro Ile 
                85                  90                  95      


Phe Thr Phe Gly Pro Gly Thr Lys Leu Glu Ile Lys 
            100                 105             


<210> 155
<211> 11
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L1"

<400> 155
Gln Ala Ser Gln Asp Ile Ser Asn Gln Leu Asn 
1               5                   10      


<210> 156
<211> 33
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L1"

<400> 156
caggcgagtc aggacattag caaccagtta aat                                    33


<210> 157
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L2"

<400> 157
Asp Ala Ser Phe Leu Gln Thr 
1               5           


<210> 158
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L2"

<400> 158
gatgcatcct ttttgcaaac a                                                 21


<210> 159
<211> 10
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L3"

<400> 159
Gln His Tyr Asp Ser Phe Pro Ile Phe Thr 
1               5                   10  


<210> 160
<211> 30
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L3"

<400> 160
cagcattatg atagtttccc catattcact                                        30


<210> 161
<211> 378
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region"

<400> 161
gaggtgcagc tggtggagtc tgggggaggc ttggtacagc ctggcaggtc cctgcgactc       60

tcctgtgcag cctctggatt cacctttgat gattatgcca tgcactgggt ccggcaagct      120

ccagggaagg gcctggagtg ggtctcaggc atcagttgga atagtggtat tgtaaagtat      180

gcggactctg tgaagggccg attcaccatc tccagagaca acgccaagaa ctccctgtat      240

ctgcaaatga acagtctgag aactgaggac acggccttgt attattgtgt aaaagacggt      300

tataccagca gttggcactc ggactaccac tacggcttgg acgtctgggg ccaagggacc      360

acggtcaccg tctcctca                                                    378


<210> 162
<211> 126
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region"

<400> 162
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Asp Tyr 
            20                  25                  30          


Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Gly Ile Ser Trp Asn Ser Gly Ile Val Lys Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Thr Glu Asp Thr Ala Leu Tyr Tyr Cys 
                85                  90                  95      


Val Lys Asp Gly Tyr Thr Ser Ser Trp His Ser Asp Tyr His Tyr Gly 
            100                 105                 110         


Leu Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120                 125     


<210> 163
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H1"

<400> 163
Phe Thr Phe Asp Asp Tyr Ala Met His 
1               5                   


<210> 164
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H1"

<400> 164
ttcacctttg atgattatgc catgcac                                           27


<210> 165
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H2"

<400> 165
Gly Ile Ser Trp Asn Ser Gly Ile Val Lys Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210> 166
<211> 51
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H2"

<400> 166
ggcatcagtt ggaatagtgg tattgtaaag tatgcggact ctgtgaaggg c                51


<210> 167
<211> 19
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H3"

<400> 167
Val Lys Asp Gly Tyr Thr Ser Ser Trp His Ser Asp Tyr His Tyr Gly 
1               5                   10                  15      


Leu Asp Val 
            


<210> 168
<211> 57
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H3"

<400> 168
gtaaaagacg gttataccag cagttggcac tcggactacc actacggctt ggacgtc          57


<210> 169
<211> 321
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region"

<400> 169
gatattgtga tgactcagtc tccagccacc ctgtctctgt ctccagggga cagagccacc       60

ctctcctgca gggccagtca gaatgttatc agcaacttgg cctggtacca gcagaaacct      120

ggccaggctc ccaggctcct catctatact gtatccacca gggccactgg tatcccagcc      180

aggttcagtg gcagtgggtc tgggacagac ttcactctca ccatcagcag cctgcagtct      240

gaagattttg cagtttatta ctgtcagcag tataataact ggcctctcac tttcggcgga      300

gggaccaagg tggaaatcaa a                                                321


<210> 170
<211> 107
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region"

<400> 170
Asp Ile Val Met Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Asp Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Asn Val Ile Ser Asn 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 
        35                  40                  45              


Tyr Thr Val Ser Thr Arg Ala Thr Gly Ile Pro Ala Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Ser 
65                  70                  75                  80  


Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Asn Asn Trp Pro Leu 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210> 171
<211> 11
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L1"

<400> 171
Arg Ala Ser Gln Asn Val Ile Ser Asn Leu Ala 
1               5                   10      


<210> 172
<211> 33
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L1"

<400> 172
agggccagtc agaatgttat cagcaacttg gcc                                    33


<210> 173
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L2"

<400> 173
Thr Val Ser Thr Arg Ala Thr 
1               5           


<210> 174
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L2"

<400> 174
actgtatcca ccagggccac t                                                 21


<210> 175
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L3"

<400> 175
Gln Gln Tyr Asn Asn Trp Pro Leu Thr 
1               5                   


<210> 176
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L3"

<400> 176
cagcagtata ataactggcc tctcact                                           27


<210> 177
<211> 372
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region"

<400> 177
caggtccagc ttgtgcagtc tggggctgag gtgaagaagc ctgggtcgtc ggtgaaggtc       60

tcctgcaagg cttctggaga caccttcaac agttattcca tcagctgggt gcgacaggcc      120

cctggacaag ggcttgagtg gatgggagga atcctcccta tgtttggttc gtcagactac      180

gcacagaagt tccagggcag actcacaatt accgcggacg aatccacgag gacagcctac      240

atggagctga acagtctgac atctgaggac acggccattt actactgtgc gagagacaat      300

tactatgttt ggactggtcg ttatcccgaa tttgacttct ggggccaggg aaccctggtc      360

accgtctcct ca                                                          372


<210> 178
<211> 124
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region"

<400> 178
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Asp Thr Phe Asn Ser Tyr 
            20                  25                  30          


Ser Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Gly Ile Leu Pro Met Phe Gly Ser Ser Asp Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Leu Thr Ile Thr Ala Asp Glu Ser Thr Arg Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Asn Ser Leu Thr Ser Glu Asp Thr Ala Ile Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Asn Tyr Tyr Val Trp Thr Gly Arg Tyr Pro Glu Phe Asp 
            100                 105                 110         


Phe Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 


<210> 179
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H1"

<400> 179
Asp Thr Phe Asn Ser Tyr Ser Ile Ser 
1               5                   


<210> 180
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H1"

<400> 180
gacaccttca acagttattc catcagc                                           27


<210> 181
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H2"

<400> 181
Gly Ile Leu Pro Met Phe Gly Ser Ser Asp Tyr Ala Gln Lys Phe Gln 
1               5                   10                  15      


Gly 
    


<210> 182
<211> 51
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H2"

<400> 182
ggaatcctcc ctatgtttgg ttcgtcagac tacgcacaga agttccaggg c                51


<210> 183
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H3"

<400> 183
Ala Arg Asp Asn Tyr Tyr Val Trp Thr Gly Arg Tyr Pro Glu Phe Asp 
1               5                   10                  15      


Phe 
    


<210> 184
<211> 51
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H3"

<400> 184
gcgagagaca attactatgt ttggactggt cgttatcccg aatttgactt c                51


<210> 185
<211> 324
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region"

<400> 185
gaaattgtgt tgacacagtc tccaggcacc ctgtccttgt ctccagggga tgaagccacc       60

ctctcctgca gggccagtca gagtgttacc agcaattact tagcctggta ccagcagagg      120

cctggccagg ctcccaggct cctcatctct ggtgcatcca gaagggccac tgccgtccca      180

gacaggttca gtggcagtgg gtctgggaca gacttcactc tcaccatcag cagactggag      240

cctgaagatt ttgcagttta ttactgtcag caatatggaa gcacaccgat caccttcggc      300

caggggacac gactggagat taaa                                             324


<210> 186
<211> 108
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region"

<400> 186
Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Asp Glu Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Thr Ser Asn 
            20                  25                  30          


Tyr Leu Ala Trp Tyr Gln Gln Arg Pro Gly Gln Ala Pro Arg Leu Leu 
        35                  40                  45              


Ile Ser Gly Ala Ser Arg Arg Ala Thr Ala Val Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu 
65                  70                  75                  80  


Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Gly Ser Thr Pro 
                85                  90                  95      


Ile Thr Phe Gly Gln Gly Thr Arg Leu Glu Ile Lys 
            100                 105             


<210> 187
<211> 12
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L1"

<400> 187
Arg Ala Ser Gln Ser Val Thr Ser Asn Tyr Leu Ala 
1               5                   10          


<210> 188
<211> 36
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L1"

<400> 188
agggccagtc agagtgttac cagcaattac ttagcc                                 36


<210> 189
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L2"

<400> 189
Gly Ala Ser Arg Arg Ala Thr 
1               5           


<210> 190
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L2"

<400> 190
ggtgcatcca gaagggccac t                                                 21


<210> 191
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L3"

<400> 191
Gln Gln Tyr Gly Ser Thr Pro Ile Thr 
1               5                   


<210> 192
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L3"

<400> 192
cagcaatatg gaagcacacc gatcacc                                           27


<210> 193
<211> 351
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region"

<400> 193
caggtccagc tggtgcagtc tggagctgag gtgaagaagc ctggggcctc agtgaaggtc       60

tcctgcaagg cttctggata cactttcacc aatgatataa actgggtgcg acaggccact      120

ggacaagggc ttgagtggat ggggtggatg aaccctaaca atggtcacac aggctatgca      180

cagagcttcg agggcagagt cagcatgacc aggaactccg ccataaacac agcctacctg      240

gagctgagca gcctgagatt tgacgatacg gccatatatt attgtgtata caatttctgg      300

agtgattctt cagtctcctg gggccaggga accctggtca ccgtctcctc a               351


<210> 194
<211> 117
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region"

<400> 194
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asn Asp 
            20                  25                  30          


Ile Asn Trp Val Arg Gln Ala Thr Gly Gln Gly Leu Glu Trp Met Gly 
        35                  40                  45              


Trp Met Asn Pro Asn Asn Gly His Thr Gly Tyr Ala Gln Ser Phe Glu 
    50                  55                  60                  


Gly Arg Val Ser Met Thr Arg Asn Ser Ala Ile Asn Thr Ala Tyr Leu 
65                  70                  75                  80  


Glu Leu Ser Ser Leu Arg Phe Asp Asp Thr Ala Ile Tyr Tyr Cys Val 
                85                  90                  95      


Tyr Asn Phe Trp Ser Asp Ser Ser Val Ser Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210> 195
<211> 8
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H1"

<400> 195
Tyr Thr Phe Thr Asn Asp Ile Asn 
1               5               


<210> 196
<211> 24
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H1"

<400> 196
tacactttca ccaatgatat aaac                                              24


<210> 197
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H2"

<400> 197
Trp Met Asn Pro Asn Asn Gly His Thr Gly Tyr Ala Gln Ser Phe Glu 
1               5                   10                  15      


Gly 
    


<210> 198
<211> 51
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H2"

<400> 198
tggatgaacc ctaacaatgg tcacacaggc tatgcacaga gcttcgaggg c                51


<210> 199
<211> 11
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H3"

<400> 199
Val Tyr Asn Phe Trp Ser Asp Ser Ser Val Ser 
1               5                   10      


<210> 200
<211> 33
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H3"

<400> 200
gtatacaatt tctggagtga ttcttcagtc tcc                                    33


<210> 201
<211> 333
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region"

<400> 201
cagtctgtcg tgacgcagcc gccctcagtg tctggggccc cagggcagag tgtcgccatc       60

tcctgcactg ggagcagctc caacatcggg ccaggttatg atgtacactg gtatcagcaa      120

cttccgggag cagcccccaa actcctcatc tatggtgaca gcaatcggcc ctcaggggtc      180

cctgaccgat tctctacctc caagtctggc acctcagttt ccctggccat cactgggctc      240

caggctgagg atgaggctga ttattactgc cagtcctatg acagcagcct ccgtggttat      300

gtcttcggaa ctgggaccaa gctcaccgtc cta                                   333


<210> 202
<211> 111
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region"

<400> 202
Gln Ser Val Val Thr Gln Pro Pro Ser Val Ser Gly Ala Pro Gly Gln 
1               5                   10                  15      


Ser Val Ala Ile Ser Cys Thr Gly Ser Ser Ser Asn Ile Gly Pro Gly 
            20                  25                  30          


Tyr Asp Val His Trp Tyr Gln Gln Leu Pro Gly Ala Ala Pro Lys Leu 
        35                  40                  45              


Leu Ile Tyr Gly Asp Ser Asn Arg Pro Ser Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Thr Ser Lys Ser Gly Thr Ser Val Ser Leu Ala Ile Thr Gly Leu 
65                  70                  75                  80  


Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Gln Ser Tyr Asp Ser Ser 
                85                  90                  95      


Leu Arg Gly Tyr Val Phe Gly Thr Gly Thr Lys Leu Thr Val Leu 
            100                 105                 110     


<210> 203
<211> 14
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L1"

<400> 203
Thr Gly Ser Ser Ser Asn Ile Gly Pro Gly Tyr Asp Val His 
1               5                   10                  


<210> 204
<211> 42
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L1"

<400> 204
actgggagca gctccaacat cgggccaggt tatgatgtac ac                          42


<210> 205
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L2"

<400> 205
Gly Asp Ser Asn Arg Pro Ser 
1               5           


<210> 206
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L2"

<400> 206
ggtgacagca atcggccctc a                                                 21


<210> 207
<211> 11
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L3"

<400> 207
Gln Ser Tyr Asp Ser Ser Leu Arg Gly Tyr Val 
1               5                   10      


<210> 208
<211> 33
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L3"

<400> 208
cagtcctatg acagcagcct ccgtggttat gtc                                    33


<210> 209
<211> 363
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region"

<400> 209
caggtccagc ttgtacagtc tggagctgag gtgaagaagc ctggggcctc agtgaaggtc       60

tcctgcaagg cttctggttt cacctttact aattatggta taagttgggt gcgacaggcc      120

cctggacgag ggcttgagtg gatgggctgg atcagcgctt acaatggtaa cacagagtat      180

gcacagaagc tccaagacag actcaccatg accacagaca catctacgaa cacagcctac      240

atggagttga ggagcctgag atctgacgac acggccctat attattgtgc gagagagtca      300

ggtgtcgcag cagctgctac cttactttac tggggccagg gaaccctggt caccgtctcc      360

tca                                                                    363


<210> 210
<211> 121
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region"

<400> 210
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Phe Thr Phe Thr Asn Tyr 
            20                  25                  30          


Gly Ile Ser Trp Val Arg Gln Ala Pro Gly Arg Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Ser Ala Tyr Asn Gly Asn Thr Glu Tyr Ala Gln Lys Leu 
    50                  55                  60                  


Gln Asp Arg Leu Thr Met Thr Thr Asp Thr Ser Thr Asn Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Arg Ser Leu Arg Ser Asp Asp Thr Ala Leu Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Glu Ser Gly Val Ala Ala Ala Ala Thr Leu Leu Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120     


<210> 211
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H1"

<400> 211
Phe Thr Phe Thr Asn Tyr Gly Ile Ser 
1               5                   


<210> 212
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H1"

<400> 212
ttcaccttta ctaattatgg tataagt                                           27


<210> 213
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H2"

<400> 213
Trp Ile Ser Ala Tyr Asn Gly Asn Thr Glu Tyr Ala Gln Lys Leu Gln 
1               5                   10                  15      


Asp 
    


<210> 214
<211> 51
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H2"

<400> 214
tggatcagcg cttacaatgg taacacagag tatgcacaga agctccaaga c                51


<210> 215
<211> 14
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H3"

<400> 215
Ala Arg Glu Ser Gly Val Ala Ala Ala Ala Thr Leu Leu Tyr 
1               5                   10                  


<210> 216
<211> 42
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H3"

<400> 216
gcgagagagt caggtgtcgc agcagctgct accttacttt ac                          42


<210> 217
<211> 336
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region"

<400> 217
gaaacgacac tcacgcagtc tccactctcc ctgcccgtca cccttggaca accggcctcc       60

atctcctgca ggtctagtca aagcctcgta tacagcgatg gaaacaccta cttgagttgg      120

tttcagcaga ggccaggcca atctccaagg cgcctaattt ataaggtttc taaccgggac      180

tctggggtcc cagacagatt cagcggcagt gggtcaggcg ctgatttcac actgaaaatc      240

agcagggtgg aggctgagga tgttggggtt tattactgca tgcaaggtat atactggcct      300

cggacgttcg gccaagggac caaagtggat atcaaa                                336


<210> 218
<211> 112
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region"

<400> 218
Glu Thr Thr Leu Thr Gln Ser Pro Leu Ser Leu Pro Val Thr Leu Gly 
1               5                   10                  15      


Gln Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Val Tyr Ser 
            20                  25                  30          


Asp Gly Asn Thr Tyr Leu Ser Trp Phe Gln Gln Arg Pro Gly Gln Ser 
        35                  40                  45              


Pro Arg Arg Leu Ile Tyr Lys Val Ser Asn Arg Asp Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Ala Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Met Gln Gly 
                85                  90                  95      


Ile Tyr Trp Pro Arg Thr Phe Gly Gln Gly Thr Lys Val Asp Ile Lys 
            100                 105                 110         


<210> 219
<211> 16
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L1"

<400> 219
Arg Ser Ser Gln Ser Leu Val Tyr Ser Asp Gly Asn Thr Tyr Leu Ser 
1               5                   10                  15      


<210> 220
<211> 48
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L1"

<400> 220
aggtctagtc aaagcctcgt atacagcgat ggaaacacct acttgagt                    48


<210> 221
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L2"

<400> 221
Lys Val Ser Asn Arg Asp Ser 
1               5           


<210> 222
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L2"

<400> 222
aaggtttcta accgggactc t                                                 21


<210> 223
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L3"

<400> 223
Met Gln Gly Ile Tyr Trp Pro Arg Thr 
1               5                   


<210> 224
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L3"

<400> 224
atgcaaggta tatactggcc tcggacg                                           27


<210> 225
<211> 390
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region"

<400> 225
caggtgcagc tggtggagtc tggggctgag gtgcagaagc ctggggcctc agtgaagatt       60

tcttgcaagg catctggata caagttcatc agctactcca tacactgggt gcgacaggcc      120

cctggacaag gacttgagtg gatgggagta atcaaccctg gtggcggtct cacaaactat      180

gcacagaagt tccaggacag actcaccatg accagggaca cgtccacggc cacagtgacc      240

atggaactga ggagcctgag atctgacgac agggccgtat atttttgtgg tagagaagac      300

tcatattgta gtggagacag ctgcttcaat tccggttcgg ggcgctgggt cgactcctgg      360

ggccagggaa ccctggtcac cgtctcctca                                       390


<210> 226
<211> 130
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region"

<400> 226
Gln Val Gln Leu Val Glu Ser Gly Ala Glu Val Gln Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Lys Phe Ile Ser Tyr 
            20                  25                  30          


Ser Ile His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Val Ile Asn Pro Gly Gly Gly Leu Thr Asn Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Asp Arg Leu Thr Met Thr Arg Asp Thr Ser Thr Ala Thr Val Thr 
65                  70                  75                  80  


Met Glu Leu Arg Ser Leu Arg Ser Asp Asp Arg Ala Val Tyr Phe Cys 
                85                  90                  95      


Gly Arg Glu Asp Ser Tyr Cys Ser Gly Asp Ser Cys Phe Asn Ser Gly 
            100                 105                 110         


Ser Gly Arg Trp Val Asp Ser Trp Gly Gln Gly Thr Leu Val Thr Val 
        115                 120                 125             


Ser Ser 
    130 


<210> 227
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H1"

<400> 227
Tyr Lys Phe Ile Ser Tyr Ser Ile His 
1               5                   


<210> 228
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H1"

<400> 228
tacaagttca tcagctactc catacac                                           27


<210> 229
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H2"

<400> 229
Val Ile Asn Pro Gly Gly Gly Leu Thr Asn Tyr Ala Gln Lys Phe Gln 
1               5                   10                  15      


Asp 
    


<210> 230
<211> 51
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H2"

<400> 230
gtaatcaacc ctggtggcgg tctcacaaac tatgcacaga agttccagga c                51


<210> 231
<211> 23
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H3"

<400> 231
Gly Arg Glu Asp Ser Tyr Cys Ser Gly Asp Ser Cys Phe Asn Ser Gly 
1               5                   10                  15      


Ser Gly Arg Trp Val Asp Ser 
            20              


<210> 232
<211> 69
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H3"

<400> 232
ggtagagaag actcatattg tagtggagac agctgcttca attccggttc ggggcgctgg       60

gtcgactcc                                                               69


<210> 233
<211> 321
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region"

<400> 233
gacatccagg tgacccagtc tccatcgtcc ctgtctgcat ctgtcggaga cagagtcacc       60

atcacttgcc gggcaagtca gagcgttatc acctatttaa attggtatca gcagaaacca      120

gggaaagccc ctcaactcct ggtctatgct gcttccattt tgcaaagtgg ggtcccatcc      180

agcttcagtg gcagtggatc tgggacagat ttcactctca ccatcagcag tctgcaacct      240

gaagattttg caacttacta ctgtcaacag acttacagta cccctcatac ttttggccag      300

gggaccaaag tggatatcaa a                                                321


<210> 234
<211> 107
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region"

<400> 234
Asp Ile Gln Val Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Val Ile Thr Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Gln Leu Leu Val 
        35                  40                  45              


Tyr Ala Ala Ser Ile Leu Gln Ser Gly Val Pro Ser Ser Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Thr Tyr Ser Thr Pro His 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Asp Ile Lys 
            100                 105         


<210> 235
<211> 11
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L1"

<400> 235
Arg Ala Ser Gln Ser Val Ile Thr Tyr Leu Asn 
1               5                   10      


<210> 236
<211> 33
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L1"

<400> 236
cgggcaagtc agagcgttat cacctattta aat                                    33


<210> 237
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L2"

<400> 237
Ala Ala Ser Ile Leu Gln Ser 
1               5           


<210> 238
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L2"

<400> 238
gctgcttcca ttttgcaaag t                                                 21


<210> 239
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L3"

<400> 239
Gln Gln Thr Tyr Ser Thr Pro His Thr 
1               5                   


<210> 240
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L3"

<400> 240
caacagactt acagtacccc tcatact                                           27


<210> 241
<211> 363
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region"

<400> 241
gaggtgcagc tggtggagtc tggagctgag gtgaagaagc ctggggcctc agtgaaggtc       60

tcctgcaagg cttctggtta cacctttgcc aactatggta tcacctgggt gcgacaggcc      120

cctggacaag ggcttgagta catgggatgg atcagcgctt acaatggtaa cacaaactat      180

gcacagaagt tccagggcag agtcaccatg accacggaca catccacgag cacagcgtac      240

atggagctga ggagcctgag atctgacgac acggccattt attactgtgc gagagatccc      300

ggtgttacgg ctgctgtgct acttgactac tggggccagg gagccctggt caccgtctcc      360

tca                                                                    363


<210> 242
<211> 121
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region"

<400> 242
Glu Val Gln Leu Val Glu Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Ala Asn Tyr 
            20                  25                  30          


Gly Ile Thr Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Tyr Met 
        35                  40                  45              


Gly Trp Ile Ser Ala Tyr Asn Gly Asn Thr Asn Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Met Thr Thr Asp Thr Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Arg Ser Leu Arg Ser Asp Asp Thr Ala Ile Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Pro Gly Val Thr Ala Ala Val Leu Leu Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Ala Leu Val Thr Val Ser Ser 
        115                 120     


<210> 243
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H1"

<400> 243
Tyr Thr Phe Ala Asn Tyr Gly Ile Thr 
1               5                   


<210> 244
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H1"

<400> 244
tacacctttg ccaactatgg tatcacc                                           27


<210> 245
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H2"

<400> 245
Trp Ile Ser Ala Tyr Asn Gly Asn Thr Asn Tyr Ala Gln Lys Phe Gln 
1               5                   10                  15      


Gly 
    


<210> 246
<211> 51
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H2"

<400> 246
tggatcagcg cttacaatgg taacacaaac tatgcacaga agttccaggg c                51


<210> 247
<211> 14
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H3"

<400> 247
Ala Arg Asp Pro Gly Val Thr Ala Ala Val Leu Leu Asp Tyr 
1               5                   10                  


<210> 248
<211> 42
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H3"

<400> 248
gcgagagatc ccggtgttac ggctgctgtg ctacttgact ac                          42


<210> 249
<211> 333
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region"

<400> 249
gatattgtgt tgacccagtc tccactctcc ctgcccgtca cccttggaca gccggcctcc       60

atctcctgca ggtctagtca aagcctcgta ttcagtgatg gaaacaccta cttgagttgg      120

tttcagcaga ggccaggcca atctccaagg cgcctacttt ataaggtttc taaccgggac      180

tctggggtcc cagacagatt cagcggcagt gggtcaggca ctgatttcac actgacaatc      240

agcagggtgg aggctgagga tgttggggtt tattactgct tgcaaggtac acccccttac      300

acttttggcc aggggaccaa agtggatatc aaa                                   333


<210> 250
<211> 111
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region"

<400> 250
Asp Ile Val Leu Thr Gln Ser Pro Leu Ser Leu Pro Val Thr Leu Gly 
1               5                   10                  15      


Gln Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Val Phe Ser 
            20                  25                  30          


Asp Gly Asn Thr Tyr Leu Ser Trp Phe Gln Gln Arg Pro Gly Gln Ser 
        35                  40                  45              


Pro Arg Arg Leu Leu Tyr Lys Val Ser Asn Arg Asp Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Leu Gln Gly 
                85                  90                  95      


Thr Pro Pro Tyr Thr Phe Gly Gln Gly Thr Lys Val Asp Ile Lys 
            100                 105                 110     


<210> 251
<211> 16
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L1"

<400> 251
Arg Ser Ser Gln Ser Leu Val Phe Ser Asp Gly Asn Thr Tyr Leu Ser 
1               5                   10                  15      


<210> 252
<211> 48
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L1"

<400> 252
aggtctagtc aaagcctcgt attcagtgat ggaaacacct acttgagt                    48


<210> 253
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L2"

<400> 253
Lys Val Ser Asn Arg Asp Ser 
1               5           


<210> 254
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L2"

<400> 254
aaggtttcta accgggactc t                                                 21


<210> 255
<211> 8
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L3"

<400> 255
Leu Gln Gly Thr Pro Pro Tyr Thr 
1               5               


<210> 256
<211> 24
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L3"

<400> 256
ttgcaaggta caccccctta cact                                              24


<210> 257
<211> 363
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region"

<400> 257
caggtgcagc tggtggagtc tgggggaggc gtggtccagc ctgggaagtc cctgagactc       60

tcctgtgcag cctctggatt caccttcagt agctatccta tgcactgggt ccgccaggct      120

ccaggcgcgg ggctggagtg gatggccgta atctcatatg atggagccaa taaatactat      180

gaagactcct taaagggccg attcaccatc tccagagaca attccaagga cactctgttt      240

ctgcaaatga acaacctgag acctgaggac acggctgtct attactgtgc gagagggagg      300

acttcgcata taaatacacc cgagactaag tggggccagg gaaccctggt caccgtctcc      360

tca                                                                    363


<210> 258
<211> 121
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region"

<400> 258
Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Lys 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Pro Met His Trp Val Arg Gln Ala Pro Gly Ala Gly Leu Glu Trp Met 
        35                  40                  45              


Ala Val Ile Ser Tyr Asp Gly Ala Asn Lys Tyr Tyr Glu Asp Ser Leu 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asp Thr Leu Phe 
65                  70                  75                  80  


Leu Gln Met Asn Asn Leu Arg Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Arg Thr Ser His Ile Asn Thr Pro Glu Thr Lys Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120     


<210> 259
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H1"

<400> 259
Phe Thr Phe Ser Ser Tyr Pro Met His 
1               5                   


<210> 260
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H1"

<400> 260
ttcaccttca gtagctatcc tatgcac                                           27


<210> 261
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H2"

<400> 261
Val Ile Ser Tyr Asp Gly Ala Asn Lys Tyr Tyr Glu Asp Ser Leu Lys 
1               5                   10                  15      


Gly 
    


<210> 262
<211> 51
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H2"

<400> 262
gtaatctcat atgatggagc caataaatac tatgaagact ccttaaaggg c                51


<210> 263
<211> 14
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H3"

<400> 263
Ala Arg Gly Arg Thr Ser His Ile Asn Thr Pro Glu Thr Lys 
1               5                   10                  


<210> 264
<211> 42
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H3"

<400> 264
gcgagaggga ggacttcgca tataaataca cccgagacta ag                          42


<210> 265
<211> 321
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region"

<400> 265
gaaattgtgt tgacgcagtc tccaacctta gtgtctgcat ctacaggaga cacagtcacc       60

atcagttgcc ggatgagtca gggcattaac ggttatttag cctggtttca gaaaaaacca      120

gggaaagccc ctgacctcct gatctatggt gcatccactt tgcaagatgg ggtcccatca      180

aggttcagtg gcagtggatc tgggacagat ttcactctca ccatcagtcg cctgcagtct      240

gaagatttgg caacttatta ttgtcaacag tattacagtt tgccgtggac gttcggccaa      300

gggaccaaag tggatatcaa a                                                321


<210> 266
<211> 107
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region"

<400> 266
Glu Ile Val Leu Thr Gln Ser Pro Thr Leu Val Ser Ala Ser Thr Gly 
1               5                   10                  15      


Asp Thr Val Thr Ile Ser Cys Arg Met Ser Gln Gly Ile Asn Gly Tyr 
            20                  25                  30          


Leu Ala Trp Phe Gln Lys Lys Pro Gly Lys Ala Pro Asp Leu Leu Ile 
        35                  40                  45              


Tyr Gly Ala Ser Thr Leu Gln Asp Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Gln Ser 
65                  70                  75                  80  


Glu Asp Leu Ala Thr Tyr Tyr Cys Gln Gln Tyr Tyr Ser Leu Pro Trp 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Asp Ile Lys 
            100                 105         


<210> 267
<211> 11
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L1"

<400> 267
Arg Met Ser Gln Gly Ile Asn Gly Tyr Leu Ala 
1               5                   10      


<210> 268
<211> 33
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L1"

<400> 268
cggatgagtc agggcattaa cggttattta gcc                                    33


<210> 269
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L2"

<400> 269
Gly Ala Ser Thr Leu Gln Asp 
1               5           


<210> 270
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L2"

<400> 270
ggtgcatcca ctttgcaaga t                                                 21


<210> 271
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L3"

<400> 271
Gln Gln Tyr Tyr Ser Leu Pro Trp Thr 
1               5                   


<210> 272
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L3"

<400> 272
caacagtatt acagtttgcc gtggacg                                           27


<210> 273
<211> 351
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region"

<400> 273
caggtccagc ttgtacagtc tggggctgag gtgaagaagc ctggggcctc agtgaaggtc       60

tcctgcaagg cttctggata cagcttcacc gactactata tacactgggt gcgacaggcc      120

cctggacaag ggcttgagtg gataggatgg atcaacccta acagtggtgg cacaaccttt      180

gcacagaact ttcagggcag ggtcaccatg accagggaca cgtccatcag cacagccttc      240

ctggagctga gcaggctaaa atctgacgac acggccgtat attattgtgc gagagacgtt      300

ctctggttaa acggattctg gggcctggga accctggtca ccgtctcttc a               351


<210> 274
<211> 117
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region"

<400> 274
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Ser Phe Thr Asp Tyr 
            20                  25                  30          


Tyr Ile His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Trp Ile Asn Pro Asn Ser Gly Gly Thr Thr Phe Ala Gln Asn Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Met Thr Arg Asp Thr Ser Ile Ser Thr Ala Phe 
65                  70                  75                  80  


Leu Glu Leu Ser Arg Leu Lys Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Val Leu Trp Leu Asn Gly Phe Trp Gly Leu Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210> 275
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H1"

<400> 275
Tyr Ser Phe Thr Asp Tyr Tyr Ile His 
1               5                   


<210> 276
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H1"

<400> 276
tacagcttca ccgactacta tatacac                                           27


<210> 277
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H2"

<400> 277
Trp Ile Asn Pro Asn Ser Gly Gly Thr Thr Phe Ala Gln Asn Phe Gln 
1               5                   10                  15      


Gly 
    


<210> 278
<211> 51
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H2"

<400> 278
tggatcaacc ctaacagtgg tggcacaacc tttgcacaga actttcaggg c                51


<210> 279
<211> 10
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H3"

<400> 279
Ala Arg Asp Val Leu Trp Leu Asn Gly Phe 
1               5                   10  


<210> 280
<211> 30
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H3"

<400> 280
gcgagagacg ttctctggtt aaacggattc                                        30


<210> 281
<211> 339
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region"

<400> 281
cagtctgtgg tgacgcagcc gccctcagtg tctgcggccc caggacagaa ggtcaccatc       60

tcctgctctg gaagcagctc caacattggg aataattatg tatcctggta tcagcagttc      120

cgaggaacag cccccaaagt cctcatttat gaaaataata agcgaacctc agggattcct      180

gaccgattct ctggctccaa gtctggcacg tcagccaccc tgggcatcac cggactccag      240

actggggacg aggccgatta ttactgcgga acatgggata gcagcctgag tactggcccc      300

tatgtggtat tcggcggagg gaccaagctg accgtccta                             339


<210> 282
<211> 113
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region"

<400> 282
Gln Ser Val Val Thr Gln Pro Pro Ser Val Ser Ala Ala Pro Gly Gln 
1               5                   10                  15      


Lys Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn 
            20                  25                  30          


Tyr Val Ser Trp Tyr Gln Gln Phe Arg Gly Thr Ala Pro Lys Val Leu 
        35                  40                  45              


Ile Tyr Glu Asn Asn Lys Arg Thr Ser Gly Ile Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Lys Ser Gly Thr Ser Ala Thr Leu Gly Ile Thr Gly Leu Gln 
65                  70                  75                  80  


Thr Gly Asp Glu Ala Asp Tyr Tyr Cys Gly Thr Trp Asp Ser Ser Leu 
                85                  90                  95      


Ser Thr Gly Pro Tyr Val Val Phe Gly Gly Gly Thr Lys Leu Thr Val 
            100                 105                 110         


Leu 
    


<210> 283
<211> 13
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L1"

<400> 283
Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn Tyr Val Ser 
1               5                   10              


<210> 284
<211> 39
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L1"

<400> 284
tctggaagca gctccaacat tgggaataat tatgtatcc                              39


<210> 285
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L2"

<400> 285
Glu Asn Asn Lys Arg Thr Ser 
1               5           


<210> 286
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L2"

<400> 286
gaaaataata agcgaacctc a                                                 21


<210> 287
<211> 14
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L3"

<400> 287
Gly Thr Trp Asp Ser Ser Leu Ser Thr Gly Pro Tyr Val Val 
1               5                   10                  


<210> 288
<211> 42
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L3"

<400> 288
ggaacatggg atagcagcct gagtactggc ccctatgtgg ta                          42


<210> 289
<211> 372
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region"

<400> 289
caggtccagc tggtgcagtc tggggctgag gcgaagaagc ctggggcctc agtgaaggtt       60

tcctgtaagg catctggata tacctttacc agctactatt tgcactgggt gcgacaggcc      120

cctggacaag ggcctgagtg gatgggaata atcaaccctg gtggtggtag cacagagttg      180

tcacagaagt tccagggcag agtcaccttg actagggaca cgtccacgag cacagtctac      240

atggaggtga ccagcctgac atctgaggac acggccgtct attactgtgc gagagcccgg      300

atacagctct gggcaccaaa ttactacggt atggacgtct ggggccaagg gaccacggtc      360

accgtctctt ca                                                          372


<210> 290
<211> 124
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region"

<400> 290
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Ala Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Tyr Leu His Trp Val Arg Gln Ala Pro Gly Gln Gly Pro Glu Trp Met 
        35                  40                  45              


Gly Ile Ile Asn Pro Gly Gly Gly Ser Thr Glu Leu Ser Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Leu Thr Arg Asp Thr Ser Thr Ser Thr Val Tyr 
65                  70                  75                  80  


Met Glu Val Thr Ser Leu Thr Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ala Arg Ile Gln Leu Trp Ala Pro Asn Tyr Tyr Gly Met Asp 
            100                 105                 110         


Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120                 


<210> 291
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H1"

<400> 291
Tyr Thr Phe Thr Ser Tyr Tyr Leu His 
1               5                   


<210> 292
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H1"

<400> 292
tataccttta ccagctacta tttgcac                                           27


<210> 293
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H2"

<400> 293
Ile Ile Asn Pro Gly Gly Gly Ser Thr Glu Leu Ser Gln Lys Phe Gln 
1               5                   10                  15      


Gly 
    


<210> 294
<211> 51
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H2"

<400> 294
ataatcaacc ctggtggtgg tagcacagag ttgtcacaga agttccaggg c                51


<210> 295
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H3"

<400> 295
Ala Arg Ala Arg Ile Gln Leu Trp Ala Pro Asn Tyr Tyr Gly Met Asp 
1               5                   10                  15      


Val 
    


<210> 296
<211> 51
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H3"

<400> 296
gcgagagccc ggatacagct ctgggcacca aattactacg gtatggacgt c                51


<210> 297
<211> 321
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region"

<400> 297
gacatccagt tgacccagtc tccatccttc ctgtctgcat ctgtaggaga cagagtcacc       60

atcacttgcc gggccagtca tggcattacc agttatttag cctggtatca gcaaaaacca      120

gggaatgccc ctaagctcct gatctatgct gcatccactt tgcaaagtgg ggtcccatca      180

aggttcagcg gcagtgggtc tgagacacag ttcactctca caatcagcgg cctgcagcct      240

gaagattttg caacttatta ctgtcaacag cttaatcgtt accctctaac gttcggccaa      300

gggaccaagg tggaaatcaa a                                                321


<210> 298
<211> 107
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region"

<400> 298
Asp Ile Gln Leu Thr Gln Ser Pro Ser Phe Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser His Gly Ile Thr Ser Tyr 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Asn Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Thr Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Glu Thr Gln Phe Thr Leu Thr Ile Ser Gly Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Leu Asn Arg Tyr Pro Leu 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210> 299
<211> 11
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L1"

<400> 299
Arg Ala Ser His Gly Ile Thr Ser Tyr Leu Ala 
1               5                   10      


<210> 300
<211> 33
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L1"

<400> 300
cgggccagtc atggcattac cagttattta gcc                                    33


<210> 301
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L2"

<400> 301
Ala Ala Ser Thr Leu Gln Ser 
1               5           


<210> 302
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L2"

<400> 302
gctgcatcca ctttgcaaag t                                                 21


<210> 303
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L3"

<400> 303
Gln Gln Leu Asn Arg Tyr Pro Leu Thr 
1               5                   


<210> 304
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L3"

<400> 304
caacagctta atcgttaccc tctaacg                                           27


<210> 305
<211> 360
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region"

<400> 305
caggtccagc ttgtgcagtc tggagctgag gtgaagaagc ctggggcctc agtgaagatc       60

tcctgcaaga cctctggtta cacctttacg agctctgtga tcagctgggt gcggcaggcc      120

cctggacaag ggcttgagtg ggtgggatgg atcaccggtc acagaagtag cacaaactat      180

gcacagagac tccagggtag agtcaccatg accacagaca catccacgag cacagcctat      240

atggagctga ggagcctgag gtctgacgac acggccgtgt attactgtgc gagagccgat      300

ggtggttcgg ggagttatta tagcgcctgg ggccagggaa ccctggtcac cgtctcctca      360


<210> 306
<211> 120
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region"

<400> 306
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Ile Ser Cys Lys Thr Ser Gly Tyr Thr Phe Thr Ser Ser 
            20                  25                  30          


Val Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Val 
        35                  40                  45              


Gly Trp Ile Thr Gly His Arg Ser Ser Thr Asn Tyr Ala Gln Arg Leu 
    50                  55                  60                  


Gln Gly Arg Val Thr Met Thr Thr Asp Thr Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Arg Ser Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ala Asp Gly Gly Ser Gly Ser Tyr Tyr Ser Ala Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser 
        115                 120 


<210> 307
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H1"

<400> 307
Tyr Thr Phe Thr Ser Ser Val Ile Ser 
1               5                   


<210> 308
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H1"

<400> 308
tacaccttta cgagctctgt gatcagc                                           27


<210> 309
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H2"

<400> 309
Trp Ile Thr Gly His Arg Ser Ser Thr Asn Tyr Ala Gln Arg Leu Gln 
1               5                   10                  15      


Gly 
    


<210> 310
<211> 51
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H2"

<400> 310
tggatcaccg gtcacagaag tagcacaaac tatgcacaga gactccaggg t                51


<210> 311
<211> 13
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H3"

<400> 311
Ala Arg Ala Asp Gly Gly Ser Gly Ser Tyr Tyr Ser Ala 
1               5                   10              


<210> 312
<211> 39
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H3"

<400> 312
gcgagagccg atggtggttc ggggagttat tatagcgcc                              39


<210> 313
<211> 324
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region"

<400> 313
tcctatgagc tgacacagcc accctcagcg tcagtggccc caggaaagac ggccaggatc       60

tcctgtgggg gaaacaacat tggaactaag agtgtccact ggtaccagca gaagccaggc      120

caggcccctg tcttggtcat ctatcatgat agccaccggc cctcagggat ccctgagcga      180

ttctctggct ccaactctgg gaacacggcc accctgacca tcagtagggt cgaagccggg      240

gatgaggccg actattattg tcagctgtgg gatagtagta gtgattccca tgtcttcgga      300

actgggacca agctcaccgt ccta                                             324


<210> 314
<211> 108
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region"

<400> 314
Ser Tyr Glu Leu Thr Gln Pro Pro Ser Ala Ser Val Ala Pro Gly Lys 
1               5                   10                  15      


Thr Ala Arg Ile Ser Cys Gly Gly Asn Asn Ile Gly Thr Lys Ser Val 
            20                  25                  30          


His Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Val Leu Val Ile Tyr 
        35                  40                  45              


His Asp Ser His Arg Pro Ser Gly Ile Pro Glu Arg Phe Ser Gly Ser 
    50                  55                  60                  


Asn Ser Gly Asn Thr Ala Thr Leu Thr Ile Ser Arg Val Glu Ala Gly 
65                  70                  75                  80  


Asp Glu Ala Asp Tyr Tyr Cys Gln Leu Trp Asp Ser Ser Ser Asp Ser 
                85                  90                  95      


His Val Phe Gly Thr Gly Thr Lys Leu Thr Val Leu 
            100                 105             


<210> 315
<211> 11
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L1"

<400> 315
Gly Gly Asn Asn Ile Gly Thr Lys Ser Val His 
1               5                   10      


<210> 316
<211> 33
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L1"

<400> 316
gggggaaaca acattggaac taagagtgtc cac                                    33


<210> 317
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L2"

<400> 317
His Asp Ser His Arg Pro Ser 
1               5           


<210> 318
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L2"

<400> 318
catgatagcc accggccctc a                                                 21


<210> 319
<211> 11
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L3"

<400> 319
Gln Leu Trp Asp Ser Ser Ser Asp Ser His Val 
1               5                   10      


<210> 320
<211> 33
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L3"

<400> 320
cagctgtggg atagtagtag tgattcccat gtc                                    33


<210> 321
<211> 357
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region"

<400> 321
caggtgcagc tggtgcagtc tgggggaggc ctggtcaagc ctggggggtc cctgagactc       60

tcctgtgcag cctcgggatt caccatcagt ggttataaca tgttctgggt ccgccagcct      120

ccggggaagg ggctggagtg ggtctcatcc attactgctg gtagtagtta tttaaactat      180

gcagactcag tgaagggccg tttcatcgtc tccagagaca acgccaagaa ttcactgtat      240

ctgcaaatga acagcctgag agccgaggac acggctgttt atttctgtgc gagagcacct      300

cttttacccg ctatgatgga cctctggggc caagggacca cggtcaccgt ctcctca         357


<210> 322
<211> 119
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region"

<400> 322
Gln Val Gln Leu Val Gln Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Ile Ser Gly Tyr 
            20                  25                  30          


Asn Met Phe Trp Val Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ser Ile Thr Ala Gly Ser Ser Tyr Leu Asn Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Ile Val Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Phe Cys 
                85                  90                  95      


Ala Arg Ala Pro Leu Leu Pro Ala Met Met Asp Leu Trp Gly Gln Gly 
            100                 105                 110         


Thr Thr Val Thr Val Ser Ser 
        115                 


<210> 323
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H1"

<400> 323
Phe Thr Ile Ser Gly Tyr Asn Met Phe 
1               5                   


<210> 324
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H1"

<400> 324
ttcaccatca gtggttataa catgttc                                           27


<210> 325
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H2"

<400> 325
Ser Ile Thr Ala Gly Ser Ser Tyr Leu Asn Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210> 326
<211> 51
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H2"

<400> 326
tccattactg ctggtagtag ttatttaaac tatgcagact cagtgaaggg c                51


<210> 327
<211> 12
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H3"

<400> 327
Ala Arg Ala Pro Leu Leu Pro Ala Met Met Asp Leu 
1               5                   10          


<210> 328
<211> 36
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H3"

<400> 328
gcgagagcac ctcttttacc cgctatgatg gacctc                                 36


<210> 329
<211> 333
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region"

<400> 329
cagtctgtct tgacgcagcc gccctcagtg tctggggccc cagggcagag ggtcaccatc       60

tcctgcactg ggagcagctc caacatcggg gcaggttatg atgtacactg gtaccagcaa      120

cttccaggaa cagcccccaa actcctcatc tatactaaca acaatcggcc ctcaggggtc      180

cctgaccgat tctctggctc caagtctggc acctcagcct ccctggccat cactgggctc      240

caggctgagg atgaggctga ctattactgc cagtcctatg acagaagcct gaatggttat      300

gtcttcggaa ctgggaccaa gctcaccgtc cta                                   333


<210> 330
<211> 111
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region"

<400> 330
Gln Ser Val Leu Thr Gln Pro Pro Ser Val Ser Gly Ala Pro Gly Gln 
1               5                   10                  15      


Arg Val Thr Ile Ser Cys Thr Gly Ser Ser Ser Asn Ile Gly Ala Gly 
            20                  25                  30          


Tyr Asp Val His Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu 
        35                  40                  45              


Leu Ile Tyr Thr Asn Asn Asn Arg Pro Ser Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Thr Gly Leu 
65                  70                  75                  80  


Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Gln Ser Tyr Asp Arg Ser 
                85                  90                  95      


Leu Asn Gly Tyr Val Phe Gly Thr Gly Thr Lys Leu Thr Val Leu 
            100                 105                 110     


<210> 331
<211> 14
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L1"

<400> 331
Thr Gly Ser Ser Ser Asn Ile Gly Ala Gly Tyr Asp Val His 
1               5                   10                  


<210> 332
<211> 42
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L1"

<400> 332
actgggagca gctccaacat cggggcaggt tatgatgtac ac                          42


<210> 333
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L2"

<400> 333
Thr Asn Asn Asn Arg Pro Ser 
1               5           


<210> 334
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L2"

<400> 334
actaacaaca atcggccctc a                                                 21


<210> 335
<211> 11
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L3"

<400> 335
Gln Ser Tyr Asp Arg Ser Leu Asn Gly Tyr Val 
1               5                   10      


<210> 336
<211> 33
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L3"

<400> 336
cagtcctatg acagaagcct gaatggttat gtc                                    33


<210> 337
<211> 351
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region"

<400> 337
caggtccagc ttgtacagtc tggggctgag gtgaagaagc ctggggcctc actgatggtc       60

tcctgctcgg cttctggata cattttcaac agtgacatca actgggtgcg acaggcccct      120

ggacaagggc ttgagtggat ggggtggatg aaccctaaga atggtcacac aggctatgca      180

caggaattcg agggcagagt cagcatgacc aggaactcct ccaaaactat tgcctatctg      240

cagctgagca gcctgacata tgaagacacg gccgtctatt attgtgttta cgatttctgg      300

agtgatgatt cagtcaagtg gggccgggga accctggtca ccgtctcctc a               351


<210> 338
<211> 117
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region"

<400> 338
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Leu Met Val Ser Cys Ser Ala Ser Gly Tyr Ile Phe Asn Ser Asp 
            20                  25                  30          


Ile Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met Gly 
        35                  40                  45              


Trp Met Asn Pro Lys Asn Gly His Thr Gly Tyr Ala Gln Glu Phe Glu 
    50                  55                  60                  


Gly Arg Val Ser Met Thr Arg Asn Ser Ser Lys Thr Ile Ala Tyr Leu 
65                  70                  75                  80  


Gln Leu Ser Ser Leu Thr Tyr Glu Asp Thr Ala Val Tyr Tyr Cys Val 
                85                  90                  95      


Tyr Asp Phe Trp Ser Asp Asp Ser Val Lys Trp Gly Arg Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210> 339
<211> 8
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H1"

<400> 339
Tyr Ile Phe Asn Ser Asp Ile Asn 
1               5               


<210> 340
<211> 24
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H1"

<400> 340
tacattttca acagtgacat caac                                              24


<210> 341
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H2"

<400> 341
Trp Met Asn Pro Lys Asn Gly His Thr Gly Tyr Ala Gln Glu Phe Glu 
1               5                   10                  15      


Gly 
    


<210> 342
<211> 51
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H2"

<400> 342
tggatgaacc ctaagaatgg tcacacaggc tatgcacagg aattcgaggg c                51


<210> 343
<211> 11
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H3"

<400> 343
Val Tyr Asp Phe Trp Ser Asp Asp Ser Val Lys 
1               5                   10      


<210> 344
<211> 33
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H3"

<400> 344
gtttacgatt tctggagtga tgattcagtc aag                                    33


<210> 345
<211> 333
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region"

<400> 345
cagtctgtgg tgacgcagcc gccctcagtg tctggggccc cagggcagag tgtcgccatc       60

tcctgctctg ggagcagctc caacatcggg ccaggttatg atgtacactg gtaccagcaa      120

cttccgggat cagcccccaa actcctcatc tacggtgaca acaatcggcc ctcaggggtc      180

cctgagcgat tctctacctc caagtctggc acctcagcct cactggccat cactgggctc      240

caggctgagg atgaggctga ttattactgc cagtcctttg acagcagcct gcgtggttat      300

gtcttcggaa ctgggaccaa ggtgaccgtc cta                                   333


<210> 346
<211> 111
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region"

<400> 346
Gln Ser Val Val Thr Gln Pro Pro Ser Val Ser Gly Ala Pro Gly Gln 
1               5                   10                  15      


Ser Val Ala Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Pro Gly 
            20                  25                  30          


Tyr Asp Val His Trp Tyr Gln Gln Leu Pro Gly Ser Ala Pro Lys Leu 
        35                  40                  45              


Leu Ile Tyr Gly Asp Asn Asn Arg Pro Ser Gly Val Pro Glu Arg Phe 
    50                  55                  60                  


Ser Thr Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Thr Gly Leu 
65                  70                  75                  80  


Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Gln Ser Phe Asp Ser Ser 
                85                  90                  95      


Leu Arg Gly Tyr Val Phe Gly Thr Gly Thr Lys Val Thr Val Leu 
            100                 105                 110     


<210> 347
<211> 14
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L1"

<400> 347
Ser Gly Ser Ser Ser Asn Ile Gly Pro Gly Tyr Asp Val His 
1               5                   10                  


<210> 348
<211> 42
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L1"

<400> 348
tctgggagca gctccaacat cgggccaggt tatgatgtac ac                          42


<210> 349
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L2"

<400> 349
Gly Asp Asn Asn Arg Pro Ser 
1               5           


<210> 350
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L2"

<400> 350
ggtgacaaca atcggccctc a                                                 21


<210> 351
<211> 11
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L3"

<400> 351
Gln Ser Phe Asp Ser Ser Leu Arg Gly Tyr Val 
1               5                   10      


<210> 352
<211> 33
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L3"

<400> 352
cagtcctttg acagcagcct gcgtggttat gtc                                    33


<210> 353
<211> 381
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region"

<400> 353
caggtccagc tggtacagtc tggagcagcg gtgaaaaagc ccggggagtc tctgaagatc       60

tcctgtaagg gttttggata cagctttacc aagtattgga tcggctgggt gcgccaggtg      120

cccgggaaag gcctggagtg gatagggatc atctctccta ctgactctaa taccagatac      180

agcccgtcct tccgaggcca ggtcaccatg tcagccgaca agtccatcag tgccgcctac      240

ctgcagtgga gcagcctgaa ggcctcggac accgccatgt attactgtgc gagacacagc      300

agtccgtata gcagtggctg gtacggagat acatacttct ttgactcctg gggccaggga      360

accctggtca ccgtctcctc a                                                381


<210> 354
<211> 127
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region"

<400> 354
Gln Val Gln Leu Val Gln Ser Gly Ala Ala Val Lys Lys Pro Gly Glu 
1               5                   10                  15      


Ser Leu Lys Ile Ser Cys Lys Gly Phe Gly Tyr Ser Phe Thr Lys Tyr 
            20                  25                  30          


Trp Ile Gly Trp Val Arg Gln Val Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Ile Ile Ser Pro Thr Asp Ser Asn Thr Arg Tyr Ser Pro Ser Phe 
    50                  55                  60                  


Arg Gly Gln Val Thr Met Ser Ala Asp Lys Ser Ile Ser Ala Ala Tyr 
65                  70                  75                  80  


Leu Gln Trp Ser Ser Leu Lys Ala Ser Asp Thr Ala Met Tyr Tyr Cys 
                85                  90                  95      


Ala Arg His Ser Ser Pro Tyr Ser Ser Gly Trp Tyr Gly Asp Thr Tyr 
            100                 105                 110         


Phe Phe Asp Ser Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125         


<210> 355
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H1"

<400> 355
Tyr Ser Phe Thr Lys Tyr Trp Ile Gly 
1               5                   


<210> 356
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H1"

<400> 356
tacagcttta ccaagtattg gatcggc                                           27


<210> 357
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H2"

<400> 357
Ile Ile Ser Pro Thr Asp Ser Asn Thr Arg Tyr Ser Pro Ser Phe Arg 
1               5                   10                  15      


Gly 
    


<210> 358
<211> 51
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H2"

<400> 358
atcatctctc ctactgactc taataccaga tacagcccgt ccttccgagg c                51


<210> 359
<211> 20
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H3"

<400> 359
Ala Arg His Ser Ser Pro Tyr Ser Ser Gly Trp Tyr Gly Asp Thr Tyr 
1               5                   10                  15      


Phe Phe Asp Ser 
            20  


<210> 360
<211> 60
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H3"

<400> 360
gcgagacaca gcagtccgta tagcagtggc tggtacggag atacatactt ctttgactcc       60


<210> 361
<211> 330
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region"

<400> 361
cagcctgtgc tgactcagcc accctcagcg tctgggaccc ccgggcagag ggtcaccatc       60

tcttgttctg gaagcaactc caacatcggg actaatactg tgaactggta ccagcagctc      120

cctggaacgg cccccaaagt cctcatccat aataataatg agcggccctc aggggtccct      180

gaccgattct ctggctccaa gtctggcacc tcagcctccc tggccatcag tgggctccag      240

tctgaggatg aggctgatta ttactgtgca gcatgggatg acagcctgag aggttatgtc      300

ttcggaactg ggaccaaggt gaccgtccta                                       330


<210> 362
<211> 110
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region"

<400> 362
Gln Pro Val Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln 
1               5                   10                  15      


Arg Val Thr Ile Ser Cys Ser Gly Ser Asn Ser Asn Ile Gly Thr Asn 
            20                  25                  30          


Thr Val Asn Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Val Leu 
        35                  40                  45              


Ile His Asn Asn Asn Glu Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Gln 
65                  70                  75                  80  


Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Asp Ser Leu 
                85                  90                  95      


Arg Gly Tyr Val Phe Gly Thr Gly Thr Lys Val Thr Val Leu 
            100                 105                 110 


<210> 363
<211> 13
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L1"

<400> 363
Ser Gly Ser Asn Ser Asn Ile Gly Thr Asn Thr Val Asn 
1               5                   10              


<210> 364
<211> 39
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L1"

<400> 364
tctggaagca actccaacat cgggactaat actgtgaac                              39


<210> 365
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L2"

<400> 365
Asn Asn Asn Glu Arg Pro Ser 
1               5           


<210> 366
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L2"

<400> 366
aataataatg agcggccctc a                                                 21


<210> 367
<211> 11
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L3"

<400> 367
Ala Ala Trp Asp Asp Ser Leu Arg Gly Tyr Val 
1               5                   10      


<210> 368
<211> 33
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L3"

<400> 368
gcagcatggg atgacagcct gagaggttat gtc                                    33


<210> 369
<211> 390
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region"

<400> 369
caggtgcagc tggtgcaatc tggggctgag gtgaagaagc ctgggtcctc ggtgaaggtc       60

tcctgcaagg cttctggagg caccttcggc agctatgcta tcagctgggt gcgacaggcc      120

cctggacaag gacttgagtg gatgggaggg accatcccta tctttggtac agcagaccac      180

gcacagaagt tccagggcag agtcacgata accgcggaca aatccacgag cacagcgtac      240

atggaactga gcagcctgag atctgaggac acggccgtgt attactgtgc gagaggtgtt      300

ttccgcgtag gttgtagtga taccagctgc ctcaaaaact actacggtac ggacgtctgg      360

ggccaaggga ccacggtcac cgtctcctca                                       390


<210> 370
<211> 130
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region"

<400> 370
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Gly Ser Tyr 
            20                  25                  30          


Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Gly Thr Ile Pro Ile Phe Gly Thr Ala Asp His Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Ala Asp Lys Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Val Phe Arg Val Gly Cys Ser Asp Thr Ser Cys Leu Lys 
            100                 105                 110         


Asn Tyr Tyr Gly Thr Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val 
        115                 120                 125             


Ser Ser 
    130 


<210> 371
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H1"

<400> 371
Gly Thr Phe Gly Ser Tyr Ala Ile Ser 
1               5                   


<210> 372
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H1"

<400> 372
ggcaccttcg gcagctatgc tatcagc                                           27


<210> 373
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H2"

<400> 373
Gly Thr Ile Pro Ile Phe Gly Thr Ala Asp His Ala Gln Lys Phe Gln 
1               5                   10                  15      


Gly 
    


<210> 374
<211> 51
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H2"

<400> 374
gggaccatcc ctatctttgg tacagcagac cacgcacaga agttccaggg c                51


<210> 375
<211> 23
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H3"

<400> 375
Ala Arg Gly Val Phe Arg Val Gly Cys Ser Asp Thr Ser Cys Leu Lys 
1               5                   10                  15      


Asn Tyr Tyr Gly Thr Asp Val 
            20              


<210> 376
<211> 69
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H3"

<400> 376
gcgagaggtg ttttccgcgt aggttgtagt gataccagct gcctcaaaaa ctactacggt       60

acggacgtc                                                               69


<210> 377
<211> 333
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region"

<400> 377
cagtctgttc tgattcagcc tgcctccgtg tctgggtctc ctggacagtc gatcaccgtc       60

tcctgcactg gatccagcgg tgacgttggt gcttataagt atgtctcctg gtaccaacaa      120

cacccaggca gaggccccaa actcataatt tatgatgtca gtgctcggcc ctcagggatt      180

tctgatcgct tctctggctc caagtctggc aacacggcct ccctgaccat ctctgggctc      240

caggctgagg acgaggctga ctattactgc agctcatatt caagcagcag cactctcgta      300

gtattcggcg gagggaccaa ggtgaccgtc cta                                   333


<210> 378
<211> 111
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region"

<400> 378
Gln Ser Val Leu Ile Gln Pro Ala Ser Val Ser Gly Ser Pro Gly Gln 
1               5                   10                  15      


Ser Ile Thr Val Ser Cys Thr Gly Ser Ser Gly Asp Val Gly Ala Tyr 
            20                  25                  30          


Lys Tyr Val Ser Trp Tyr Gln Gln His Pro Gly Arg Gly Pro Lys Leu 
        35                  40                  45              


Ile Ile Tyr Asp Val Ser Ala Arg Pro Ser Gly Ile Ser Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Asn Thr Ala Ser Leu Thr Ile Ser Gly Leu 
65                  70                  75                  80  


Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Ser Ser Tyr Ser Ser Ser 
                85                  90                  95      


Ser Thr Leu Val Val Phe Gly Gly Gly Thr Lys Val Thr Val Leu 
            100                 105                 110     


<210> 379
<211> 14
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L1"

<400> 379
Thr Gly Ser Ser Gly Asp Val Gly Ala Tyr Lys Tyr Val Ser 
1               5                   10                  


<210> 380
<211> 42
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L1"

<400> 380
actggatcca gcggtgacgt tggtgcttat aagtatgtct cc                          42


<210> 381
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L2"

<400> 381
Asp Val Ser Ala Arg Pro Ser 
1               5           


<210> 382
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L2"

<400> 382
gatgtcagtg ctcggccctc a                                                 21


<210> 383
<211> 11
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L3"

<400> 383
Ser Ser Tyr Ser Ser Ser Ser Thr Leu Val Val 
1               5                   10      


<210> 384
<211> 33
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L3"

<400> 384
agctcatatt caagcagcag cactctcgta gta                                    33


<210> 385
<211> 375
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region"

<400> 385
caggtccagc tggtgcagtc tgggggaggg ttggtgcagc ctggggggtc cctgagactc       60

tcttgtgtag gctctggatt caccttcagt acctatagta tgaactgggt ccgtcaggct      120

ccagggaagg ggctggagtg ggtttcacac attagtagta gtagtgttac catgtactac      180

gcagactttg tgaagggccg attcaccatc tccagagaca atgccaagaa ctcactgtat      240

ctgcaaatga ccagcctgag agccgaggac acggctgtgt attactgtgc gagagatgcg      300

ggaccagttt ggagtggtta ttacgactac ggtatggacg tctggggcca agggaccacg      360

gtcactgtct cctca                                                       375


<210> 386
<211> 125
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region"

<400> 386
Gln Val Gln Leu Val Gln Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Val Gly Ser Gly Phe Thr Phe Ser Thr Tyr 
            20                  25                  30          


Ser Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser His Ile Ser Ser Ser Ser Val Thr Met Tyr Tyr Ala Asp Phe Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Thr Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Ala Gly Pro Val Trp Ser Gly Tyr Tyr Asp Tyr Gly Met 
            100                 105                 110         


Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120                 125 


<210> 387
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H1"

<400> 387
Phe Thr Phe Ser Thr Tyr Ser Met Asn 
1               5                   


<210> 388
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H1"

<400> 388
ttcaccttca gtacctatag tatgaac                                           27


<210> 389
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H2"

<400> 389
His Ile Ser Ser Ser Ser Val Thr Met Tyr Tyr Ala Asp Phe Val Lys 
1               5                   10                  15      


Gly 
    


<210> 390
<211> 51
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H2"

<400> 390
cacattagta gtagtagtgt taccatgtac tacgcagact ttgtgaaggg c                51


<210> 391
<211> 18
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H3"

<400> 391
Ala Arg Asp Ala Gly Pro Val Trp Ser Gly Tyr Tyr Asp Tyr Gly Met 
1               5                   10                  15      


Asp Val 
        


<210> 392
<211> 54
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H3"

<400> 392
gcgagagatg cgggaccagt ttggagtggt tattacgact acggtatgga cgtc             54


<210> 393
<211> 324
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region"

<400> 393
gaaacgacac tcacgcagtc tccagccacg ctgtctttgt ctccagggga aagagccacc       60

ctctcctgca gggccagtca gagtgttagc agcctcttag cctggtacca acagaaacct      120

ggccaggctc ccaggctcct catttttgat gcatccaaga gggccactgg catcccagcc      180

aggttcagtg gcagtgggtc tgggacagac ttcactctca ccatcagcag cctagagcct      240

gaagattttg cagtctatta ctgtcagcag cgttacaact ggcctccgct cactttcggc      300

ggagggacca aggtggaaat caaa                                             324


<210> 394
<211> 108
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region"

<400> 394
Glu Thr Thr Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Leu 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 
        35                  40                  45              


Phe Asp Ala Ser Lys Arg Ala Thr Gly Ile Pro Ala Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Arg Tyr Asn Trp Pro Pro 
                85                  90                  95      


Leu Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105             


<210> 395
<211> 11
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L1"

<400> 395
Arg Ala Ser Gln Ser Val Ser Ser Leu Leu Ala 
1               5                   10      


<210> 396
<211> 33
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L1"

<400> 396
agggccagtc agagtgttag cagcctctta gcc                                    33


<210> 397
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L2"

<400> 397
Asp Ala Ser Lys Arg Ala Thr 
1               5           


<210> 398
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L2"

<400> 398
gatgcatcca agagggccac t                                                 21


<210> 399
<211> 10
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L3"

<400> 399
Gln Gln Arg Tyr Asn Trp Pro Pro Leu Thr 
1               5                   10  


<210> 400
<211> 30
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L3"

<400> 400
cagcagcgtt acaactggcc tccgctcact                                        30


<210> 401
<211> 366
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region"

<400> 401
gaggtgcagc tggtggagtc tgggggaggc ttggtccagc ctggcaggtc cctgagactc       60

tcctgtgcag cctttggatt cacctttgat gattatgcca tgcactgggt ccggcaagct      120

ccagggaagg gcctggagtg ggtctcaggt attagttgga atagtggttt cataggctat      180

gcggactctg tgaagggccg attcaccatc tccagagaca atgccaagaa ctccctgtct      240

ctgcaaatga acagtctgag aactgaggat acggccttgt attactgtgc aaaaactgat      300

ggagcagtgg ctgtcgacgg gccctttgac tactggggcc agggaaccct ggtcaccgtc      360

tcctca                                                                 366


<210> 402
<211> 122
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region"

<400> 402
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Phe Gly Phe Thr Phe Asp Asp Tyr 
            20                  25                  30          


Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Gly Ile Ser Trp Asn Ser Gly Phe Ile Gly Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Ser 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Thr Glu Asp Thr Ala Leu Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Thr Asp Gly Ala Val Ala Val Asp Gly Pro Phe Asp Tyr Trp 
            100                 105                 110         


Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120         


<210> 403
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H1"

<400> 403
Phe Thr Phe Asp Asp Tyr Ala Met His 
1               5                   


<210> 404
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H1"

<400> 404
ttcacctttg atgattatgc catgcac                                           27


<210> 405
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H2"

<400> 405
Gly Ile Ser Trp Asn Ser Gly Phe Ile Gly Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210> 406
<211> 51
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H2"

<400> 406
ggtattagtt ggaatagtgg tttcataggc tatgcggact ctgtgaaggg c                51


<210> 407
<211> 15
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H3"

<400> 407
Ala Lys Thr Asp Gly Ala Val Ala Val Asp Gly Pro Phe Asp Tyr 
1               5                   10                  15  


<210> 408
<211> 45
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H3"

<400> 408
gcaaaaactg atggagcagt ggctgtcgac gggccctttg actac                       45


<210> 409
<211> 321
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region"

<400> 409
gaaattgtgt tgacacagtc tccatcctcc ctgtctgcat ctgtaggaga cagagtcacc       60

atcacttgcc gggcaagtca gagcattagc ggctatttaa gttggtatca gcagaaacca      120

gggaaagccc ctaagctcct gatccattct acatctagtt tgcaaagtgg ggtcccatca      180

aggttcagtg gcagtggatc tgggacagat ttcactctca ccatcaccag tctgcaacct      240

gaggattttg caacttacta ctgtcaacag agttacattg cccctccgac ttttggccag      300

gggaccaagg tggaaatcaa a                                                321


<210> 410
<211> 107
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region"

<400> 410
Glu Ile Val Leu Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Gly Tyr 
            20                  25                  30          


Leu Ser Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


His Ser Thr Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Thr Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Tyr Ile Ala Pro Pro 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210> 411
<211> 11
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L1"

<400> 411
Arg Ala Ser Gln Ser Ile Ser Gly Tyr Leu Ser 
1               5                   10      


<210> 412
<211> 33
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L1"

<400> 412
cgggcaagtc agagcattag cggctattta agt                                    33


<210> 413
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L2"

<400> 413
Ser Thr Ser Ser Leu Gln Ser 
1               5           


<210> 414
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L2"

<400> 414
tctacatcta gtttgcaaag t                                                 21


<210> 415
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L3"

<400> 415
Gln Gln Ser Tyr Ile Ala Pro Pro Thr 
1               5                   


<210> 416
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L3"

<400> 416
caacagagtt acattgcccc tccgact                                           27


<210> 417
<211> 348
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region"

<400> 417
caggtccagc tggtacagtc tggggctgag gtgaagaagc ctgggtcctc gatgaaggtc       60

tcctgccagg cttctggagg ccccttcagc acctatacta tcagctgggt gcgacaggcc      120

cctggacaag ggcttgagtg gatgggaggt atcatccctg tctttggtac accaaactac      180

gcgcagaagt tccacggcag agtcacgatt accgcggacc aatccacgag cacagcctac      240

atggagttga gtagcctgag atctgaggac accgccgttt attactgtgc gggagccccc      300

taccctatgg acgtctgggg ccaagggacc acggtcaccg tctcctca                   348


<210> 418
<211> 116
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region"

<400> 418
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Met Lys Val Ser Cys Gln Ala Ser Gly Gly Pro Phe Ser Thr Tyr 
            20                  25                  30          


Thr Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Gly Ile Ile Pro Val Phe Gly Thr Pro Asn Tyr Ala Gln Lys Phe 
    50                  55                  60                  


His Gly Arg Val Thr Ile Thr Ala Asp Gln Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Gly Ala Pro Tyr Pro Met Asp Val Trp Gly Gln Gly Thr Thr Val 
            100                 105                 110         


Thr Val Ser Ser 
        115     


<210> 419
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H1"

<400> 419
Gly Pro Phe Ser Thr Tyr Thr Ile Ser 
1               5                   


<210> 420
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H1"

<400> 420
ggccccttca gcacctatac tatcagc                                           27


<210> 421
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H2"

<400> 421
Gly Ile Ile Pro Val Phe Gly Thr Pro Asn Tyr Ala Gln Lys Phe His 
1               5                   10                  15      


Gly 
    


<210> 422
<211> 51
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H2"

<400> 422
ggtatcatcc ctgtctttgg tacaccaaac tacgcgcaga agttccacgg c                51


<210> 423
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H3"

<400> 423
Ala Gly Ala Pro Tyr Pro Met Asp Val 
1               5                   


<210> 424
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H3"

<400> 424
gcgggagccc cctaccctat ggacgtc                                           27


<210> 425
<211> 324
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region"

<400> 425
gaaattgtat tgacacagtc tccagccacc ctgtctttgt ctccagggga gagagccacc       60

ctctcctgca gggccagtca gagtgttgcc agctccttag cctggtacca acagaaacct      120

ggccaggctc ccaggctcct catctatgat gcatccaaca gggccactgg catcccagcc      180

aggttcagtg gcagtgggtc tgggacagac ttcactctca ccatcagcag cctagagcct      240

gaagattttg cagtttatta ctgtcagcag cgtaccaact ggcaggggct ctctttcggc      300

ggagggacca aagtggatat caaa                                             324


<210> 426
<211> 108
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region"

<400> 426
Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ala Ser Ser 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 
        35                  40                  45              


Tyr Asp Ala Ser Asn Arg Ala Thr Gly Ile Pro Ala Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Arg Thr Asn Trp Gln Gly 
                85                  90                  95      


Leu Ser Phe Gly Gly Gly Thr Lys Val Asp Ile Lys 
            100                 105             


<210> 427
<211> 11
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L1"

<400> 427
Arg Ala Ser Gln Ser Val Ala Ser Ser Leu Ala 
1               5                   10      


<210> 428
<211> 33
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L1"

<400> 428
agggccagtc agagtgttgc cagctcctta gcc                                    33


<210> 429
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L2"

<400> 429
Asp Ala Ser Asn Arg Ala Thr 
1               5           


<210> 430
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L2"

<400> 430
gatgcatcca acagggccac t                                                 21


<210> 431
<211> 10
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L3"

<400> 431
Gln Gln Arg Thr Asn Trp Gln Gly Leu Ser 
1               5                   10  


<210> 432
<211> 30
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L3"

<400> 432
cagcagcgta ccaactggca ggggctctct                                        30


<210> 433
<211> 366
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region"

<400> 433
caggtccagc ttgtgcagtc tggaggtgag gtcaagaagc ctggggcctc agtgaaggtc       60

tcctgcaagg cttctggtta cacctttatc agttatggta tcacctgggt gcgacaggcc      120

cctggacaag ggcctgagtg gatgggatgg atcagccctt acaacggtga cacaaactat      180

gcacagaagc tccagggcag agtcaccatg accacagaca catccacgac cacagcctac      240

atggaactga ggagcctgag atctgacgac acggccatat attattgtgc gagacggtac      300

gatattttga ctggcggggg ctggttcgac tcctggggcc agggaaccct ggtcaccgtc      360

tcctca                                                                 366


<210> 434
<211> 122
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region"

<400> 434
Gln Val Gln Leu Val Gln Ser Gly Gly Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Ile Ser Tyr 
            20                  25                  30          


Gly Ile Thr Trp Val Arg Gln Ala Pro Gly Gln Gly Pro Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Ser Pro Tyr Asn Gly Asp Thr Asn Tyr Ala Gln Lys Leu 
    50                  55                  60                  


Gln Gly Arg Val Thr Met Thr Thr Asp Thr Ser Thr Thr Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Arg Ser Leu Arg Ser Asp Asp Thr Ala Ile Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Arg Tyr Asp Ile Leu Thr Gly Gly Gly Trp Phe Asp Ser Trp 
            100                 105                 110         


Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120         


<210> 435
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H1"

<400> 435
Tyr Thr Phe Ile Ser Tyr Gly Ile Thr 
1               5                   


<210> 436
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H1"

<400> 436
tacaccttta tcagttatgg tatcacc                                           27


<210> 437
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H2"

<400> 437
Trp Ile Ser Pro Tyr Asn Gly Asp Thr Asn Tyr Ala Gln Lys Leu Gln 
1               5                   10                  15      


Gly 
    


<210> 438
<211> 51
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H2"

<400> 438
tggatcagcc cttacaacgg tgacacaaac tatgcacaga agctccaggg c                51


<210> 439
<211> 15
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H3"

<400> 439
Ala Arg Arg Tyr Asp Ile Leu Thr Gly Gly Gly Trp Phe Asp Ser 
1               5                   10                  15  


<210> 440
<211> 45
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H3"

<400> 440
gcgagacggt acgatatttt gactggcggg ggctggttcg actcc                       45


<210> 441
<211> 321
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region"

<400> 441
gatattgtga tgactcagtc tccttcctcc ctgtctgcat ctgtaggaga cagagtcacc       60

atcaattgcc gggcaagtca gagcattatc agctatttaa attggtatca gcaaaaacca      120

gggaaagccc ctgagctcct aatctatgct gcgtccagtt tgcaaagtgg ggtcccatca      180

aggttcagtg gcagtggatc tgggacagag ttcactctca ccatcagcag tctgcaacct      240

gaagattttg caacgtacta ctgtcaacag agttacagta cccctcttag tttcggccct      300

gggaccaagg tggagatcaa a                                                321


<210> 442
<211> 107
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region"

<400> 442
Asp Ile Val Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Asn Cys Arg Ala Ser Gln Ser Ile Ile Ser Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Glu Leu Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Tyr Ser Thr Pro Leu 
                85                  90                  95      


Ser Phe Gly Pro Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210> 443
<211> 11
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L1"

<400> 443
Arg Ala Ser Gln Ser Ile Ile Ser Tyr Leu Asn 
1               5                   10      


<210> 444
<211> 33
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L1"

<400> 444
cgggcaagtc agagcattat cagctattta aat                                    33


<210> 445
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L2"

<400> 445
Ala Ala Ser Ser Leu Gln Ser 
1               5           


<210> 446
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L2"

<400> 446
gctgcgtcca gtttgcaaag t                                                 21


<210> 447
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L3"

<400> 447
Gln Gln Ser Tyr Ser Thr Pro Leu Ser 
1               5                   


<210> 448
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L3"

<400> 448
caacagagtt acagtacccc tcttagt                                           27


<210> 449
<211> 369
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region"

<400> 449
caggtccagc ttgtgcagtc tggagcagag gtgaaaaagc ccggggagtc tctgaagatc       60

tcctgtaaga cttctggata caaatttacc aattactgga tcggctgggt gcgccagatg      120

cccgggaaag gcctggagtg gatggggatc atctatcctg gtgactctga tgccagatac      180

agcccgtcct tccaaggcca ggtcaccttc tcagccgaca agtccatcag caccgcctac      240

ctgcagtgga gcagcctgaa ggcctcggac accgccatgt attactgtgc gagacaagat      300

aacagtggct gggccgactt ctttcccttt gactactggg gccagggaac cctggtcacc      360

gtctcctca                                                              369


<210> 450
<211> 123
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region"

<400> 450
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu 
1               5                   10                  15      


Ser Leu Lys Ile Ser Cys Lys Thr Ser Gly Tyr Lys Phe Thr Asn Tyr 
            20                  25                  30          


Trp Ile Gly Trp Val Arg Gln Met Pro Gly Lys Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Ile Ile Tyr Pro Gly Asp Ser Asp Ala Arg Tyr Ser Pro Ser Phe 
    50                  55                  60                  


Gln Gly Gln Val Thr Phe Ser Ala Asp Lys Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Trp Ser Ser Leu Lys Ala Ser Asp Thr Ala Met Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gln Asp Asn Ser Gly Trp Ala Asp Phe Phe Pro Phe Asp Tyr 
            100                 105                 110         


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120             


<210> 451
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H1"

<400> 451
Tyr Lys Phe Thr Asn Tyr Trp Ile Gly 
1               5                   


<210> 452
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H1"

<400> 452
tacaaattta ccaattactg gatcggc                                           27


<210> 453
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H2"

<400> 453
Ile Ile Tyr Pro Gly Asp Ser Asp Ala Arg Tyr Ser Pro Ser Phe Gln 
1               5                   10                  15      


Gly 
    


<210> 454
<211> 51
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H2"

<400> 454
atcatctatc ctggtgactc tgatgccaga tacagcccgt ccttccaagg c                51


<210> 455
<211> 16
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H3"

<400> 455
Ala Arg Gln Asp Asn Ser Gly Trp Ala Asp Phe Phe Pro Phe Asp Tyr 
1               5                   10                  15      


<210> 456
<211> 48
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H3"

<400> 456
gcgagacaag ataacagtgg ctgggccgac ttctttccct ttgactac                    48


<210> 457
<211> 324
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region"

<400> 457
gaaacgacac tcacgcagtc tccaggcacc ctgtctttgt ctccagggga aagagccacc       60

ctctcctgca gggccagtca cagttttagc agcagctact tagcctggta ccagcagaaa      120

cctggccagg ctcccaggct cctcatctat gctgcatcca acagggccac tggcatccca      180

gacaggttca gtggcagtgg gtctgggaca gacttcactc tcaccatcag cagactggag      240

cctgaagatt ttgcagtgta tttctgtcag cagtatgata gctcaccgtg gacgttcggc      300

caagggacca aggtggagat caaa                                             324


<210> 458
<211> 108
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region"

<400> 458
Glu Thr Thr Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser His Ser Phe Ser Ser Ser 
            20                  25                  30          


Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu 
        35                  40                  45              


Ile Tyr Ala Ala Ser Asn Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu 
65                  70                  75                  80  


Pro Glu Asp Phe Ala Val Tyr Phe Cys Gln Gln Tyr Asp Ser Ser Pro 
                85                  90                  95      


Trp Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105             


<210> 459
<211> 12
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L1"

<400> 459
Arg Ala Ser His Ser Phe Ser Ser Ser Tyr Leu Ala 
1               5                   10          


<210> 460
<211> 36
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L1"

<400> 460
agggccagtc acagttttag cagcagctac ttagcc                                 36


<210> 461
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L2"

<400> 461
Ala Ala Ser Asn Arg Ala Thr 
1               5           


<210> 462
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L2"

<400> 462
gctgcatcca acagggccac t                                                 21


<210> 463
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L3"

<400> 463
Gln Gln Tyr Asp Ser Ser Pro Trp Thr 
1               5                   


<210> 464
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L3"

<400> 464
cagcagtatg atagctcacc gtggacg                                           27


<210> 465
<211> 372
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region"

<400> 465
gaggtgcagc tggtggagtc tgggggaggc gtggtccagc ctgggaaatc cctgagactc       60

tcctgtgccg cgtcgggatt catcttcagt ggctatggca tgcactgggt ccgccaggct      120

ccaggcaagg ggctggagtg ggtggcgttt atatggtttg atggaagttc tacatattat      180

gcagactccg tgaagggccg tttcaccatc tccaaagacg attccaagca gacggtatat      240

ttgcaaatga acaggctgag agccgaggac acggctgtct actactgtgc gagagacccc      300

ttatttttat acaattataa tgacgaacct tttgactact ggggacaggg aaccctggtc      360

accgtctcct ca                                                          372


<210> 466
<211> 124
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region"

<400> 466
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Lys 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ile Phe Ser Gly Tyr 
            20                  25                  30          


Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Phe Ile Trp Phe Asp Gly Ser Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Lys Asp Asp Ser Lys Gln Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Arg Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Pro Leu Phe Leu Tyr Asn Tyr Asn Asp Glu Pro Phe Asp 
            100                 105                 110         


Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 


<210> 467
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H1"

<400> 467
Phe Ile Phe Ser Gly Tyr Gly Met His 
1               5                   


<210> 468
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H1"

<400> 468
ttcatcttca gtggctatgg catgcac                                           27


<210> 469
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H2"

<400> 469
Phe Ile Trp Phe Asp Gly Ser Ser Thr Tyr Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210> 470
<211> 51
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H2"

<400> 470
tttatatggt ttgatggaag ttctacatat tatgcagact ccgtgaaggg c                51


<210> 471
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H3"

<400> 471
Ala Arg Asp Pro Leu Phe Leu Tyr Asn Tyr Asn Asp Glu Pro Phe Asp 
1               5                   10                  15      


Tyr 
    


<210> 472
<211> 51
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H3"

<400> 472
gcgagagacc ccttattttt atacaattat aatgacgaac cttttgacta c                51


<210> 473
<211> 330
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region"

<400> 473
tcctatgagc tgacacagcc accctcagcg tctggttccc ccgggcagag cgtcaccatc       60

tcttgttctg gaagcagctc caatatcggg ggtaattttg tgtactggta ccagcaactg      120

cccggaacgg cccccaaagt cctcatctat aggaataatc agcggccctc aggggtccct      180

gaccgattct ctggctccaa gtctggcact tcagcctccc tggccatcag tgggctccgg      240

tccgacgatg aggctgatta ttattgttca gtatgggatg acagcctaaa tggtcggctg      300

ttcggcggag ggaccaagct gaccgtccta                                       330


<210> 474
<211> 110
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region"

<400> 474
Ser Tyr Glu Leu Thr Gln Pro Pro Ser Ala Ser Gly Ser Pro Gly Gln 
1               5                   10                  15      


Ser Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Gly Asn 
            20                  25                  30          


Phe Val Tyr Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Val Leu 
        35                  40                  45              


Ile Tyr Arg Asn Asn Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Arg 
65                  70                  75                  80  


Ser Asp Asp Glu Ala Asp Tyr Tyr Cys Ser Val Trp Asp Asp Ser Leu 
                85                  90                  95      


Asn Gly Arg Leu Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 110 


<210> 475
<211> 13
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L1"

<400> 475
Ser Gly Ser Ser Ser Asn Ile Gly Gly Asn Phe Val Tyr 
1               5                   10              


<210> 476
<211> 39
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L1"

<400> 476
tctggaagca gctccaatat cgggggtaat tttgtgtac                              39


<210> 477
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L2"

<400> 477
Arg Asn Asn Gln Arg Pro Ser 
1               5           


<210> 478
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L2"

<400> 478
aggaataatc agcggccctc a                                                 21


<210> 479
<211> 11
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L3"

<400> 479
Ser Val Trp Asp Asp Ser Leu Asn Gly Arg Leu 
1               5                   10      


<210> 480
<211> 33
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L3"

<400> 480
tcagtatggg atgacagcct aaatggtcgg ctg                                    33


<210> 481
<211> 369
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region"

<400> 481
gaggtgcagc tggtggagtc tgggggaggt gtggtccggc ctggggggtc cctgagactc       60

tcctgtgcag cctctggatt caagtttgat gattatggca tgagctgggt ccgccaagct      120

ccagggaagg ggctggagtg ggtctctgca attatttgga atagtggtag cacaggttat      180

gcagactctg tgaagggccg attcatcatc tccagagaca acgccaagaa ctccctgtat      240

ctgcaaatga atagtctgag agccgaagac acggccttgt attactgtgc gagagtcggg      300

gggataacga agtggtggta ctacggtatg gacctctggg gccaagggac cacggtcacc      360

gtctcctca                                                              369


<210> 482
<211> 123
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region"

<400> 482
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Arg Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Lys Phe Asp Asp Tyr 
            20                  25                  30          


Gly Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ala Ile Ile Trp Asn Ser Gly Ser Thr Gly Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Ile Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Leu Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Val Gly Gly Ile Thr Lys Trp Trp Tyr Tyr Gly Met Asp Leu 
            100                 105                 110         


Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120             


<210> 483
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H1"

<400> 483
Phe Lys Phe Asp Asp Tyr Gly Met Ser 
1               5                   


<210> 484
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H1"

<400> 484
ttcaagtttg atgattatgg catgagc                                           27


<210> 485
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H2"

<400> 485
Ala Ile Ile Trp Asn Ser Gly Ser Thr Gly Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210> 486
<211> 51
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H2"

<400> 486
gcaattattt ggaatagtgg tagcacaggt tatgcagact ctgtgaaggg c                51


<210> 487
<211> 16
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H3"

<400> 487
Ala Arg Val Gly Gly Ile Thr Lys Trp Trp Tyr Tyr Gly Met Asp Leu 
1               5                   10                  15      


<210> 488
<211> 48
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H3"

<400> 488
gcgagagtcg gggggataac gaagtggtgg tactacggta tggacctc                    48


<210> 489
<211> 321
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region"

<400> 489
gaaacgacac tcacgcagtc tccatccttc ctgtctgcat ctgtcggaga cagagtcacc       60

atcacttgcc gggccagtca gggcttgagc aattatttag cctggtatca gcaaaaacca      120

gggagagccc ccaagctcct gatctatgct gcatccactt tgcaaagtgg ggtcccatca      180

aggttcagag gcagtggatc tgggacagag ttcactctca caatcagcag cctgcagcct      240

gaagatcttg caacttatta ctgtcaacac cttaatagtt accctctcac tttcggcgga      300

gggaccaagg tggagatcaa a                                                321


<210> 490
<211> 107
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region"

<400> 490
Glu Thr Thr Leu Thr Gln Ser Pro Ser Phe Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Leu Ser Asn Tyr 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Arg Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Thr Leu Gln Ser Gly Val Pro Ser Arg Phe Arg Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Leu Ala Thr Tyr Tyr Cys Gln His Leu Asn Ser Tyr Pro Leu 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210> 491
<211> 11
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L1"

<400> 491
Arg Ala Ser Gln Gly Leu Ser Asn Tyr Leu Ala 
1               5                   10      


<210> 492
<211> 33
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L1"

<400> 492
cgggccagtc agggcttgag caattattta gcc                                    33


<210> 493
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L2"

<400> 493
Ala Ala Ser Thr Leu Gln Ser 
1               5           


<210> 494
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L2"

<400> 494
gctgcatcca ctttgcaaag t                                                 21


<210> 495
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L3"

<400> 495
Gln His Leu Asn Ser Tyr Pro Leu Thr 
1               5                   


<210> 496
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L3"

<400> 496
caacacctta atagttaccc tctcact                                           27


<210> 497
<211> 372
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region"

<400> 497
gaggtgcagc tggtggagtc gggccccgga ctggtgaagc cttcggagac cctgtccctc       60

atctgcagag tctttggtgg gtccgtcagg aggggggact acaactggaa ttggatccgg      120

cagcccccag ggaagggact ggagtggatt ggctatatcg attatagtgg gaccaccaag      180

tacaatccct ccctcaagag ccgagtgacc atatcagaag acacgtccag gaatcagttc      240

tccctggagc tgaggtctgt gaccgccgcg gacacggcca tgtattactg tgcgagagac      300

gttggaagta ctccctacaa ctattacggt atggacgtct ggggccaagg gaccacggtc      360

accgtctcct ca                                                          372


<210> 498
<211> 124
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region"

<400> 498
Glu Val Gln Leu Val Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Ile Cys Arg Val Phe Gly Gly Ser Val Arg Arg Gly 
            20                  25                  30          


Asp Tyr Asn Trp Asn Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu 
        35                  40                  45              


Trp Ile Gly Tyr Ile Asp Tyr Ser Gly Thr Thr Lys Tyr Asn Pro Ser 
    50                  55                  60                  


Leu Lys Ser Arg Val Thr Ile Ser Glu Asp Thr Ser Arg Asn Gln Phe 
65                  70                  75                  80  


Ser Leu Glu Leu Arg Ser Val Thr Ala Ala Asp Thr Ala Met Tyr Tyr 
                85                  90                  95      


Cys Ala Arg Asp Val Gly Ser Thr Pro Tyr Asn Tyr Tyr Gly Met Asp 
            100                 105                 110         


Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120                 


<210> 499
<211> 11
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H1"

<400> 499
Gly Ser Val Arg Arg Gly Asp Tyr Asn Trp Asn 
1               5                   10      


<210> 500
<211> 33
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H1"

<400> 500
gggtccgtca ggagggggga ctacaactgg aat                                    33


<210> 501
<211> 16
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H2"

<400> 501
Tyr Ile Asp Tyr Ser Gly Thr Thr Lys Tyr Asn Pro Ser Leu Lys Ser 
1               5                   10                  15      


<210> 502
<211> 48
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H2"

<400> 502
tatatcgatt atagtgggac caccaagtac aatccctccc tcaagagc                    48


<210> 503
<211> 16
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H3"

<400> 503
Ala Arg Asp Val Gly Ser Thr Pro Tyr Asn Tyr Tyr Gly Met Asp Val 
1               5                   10                  15      


<210> 504
<211> 48
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H3"

<400> 504
gcgagagacg ttggaagtac tccctacaac tattacggta tggacgtc                    48


<210> 505
<211> 327
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region"

<400> 505
gaaattgtgt tgacgcagtc tccaggcacc ctgtccttgt ctccagggga aagagccacc       60

ctctcctgta gggccagtca gactattaaa aacaactact tagcctggta ccaacagaaa      120

cctggccagg ctcccaggct cctcatgtat ggtgtatcca gcaggccgac tggcatccca      180

gacaggttca gtggcagtgg gtctgggaca gacttcagtc tcaccatcga cagactggag      240

cctgaagatt ttgcagtata ttactgtcag cagtttggta ggtcaccgga gctcactttc      300

ggcggaggga ccaaggtgga aatcaaa                                          327


<210> 506
<211> 109
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region"

<400> 506
Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Thr Ile Lys Asn Asn 
            20                  25                  30          


Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu 
        35                  40                  45              


Met Tyr Gly Val Ser Ser Arg Pro Thr Gly Ile Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Asp Phe Ser Leu Thr Ile Asp Arg Leu Glu 
65                  70                  75                  80  


Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Phe Gly Arg Ser Pro 
                85                  90                  95      


Glu Leu Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105                 


<210> 507
<211> 12
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L1"

<400> 507
Arg Ala Ser Gln Thr Ile Lys Asn Asn Tyr Leu Ala 
1               5                   10          


<210> 508
<211> 36
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L1"

<400> 508
agggccagtc agactattaa aaacaactac ttagcc                                 36


<210> 509
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L2"

<400> 509
Gly Val Ser Ser Arg Pro Thr 
1               5           


<210> 510
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L2"

<400> 510
ggtgtatcca gcaggccgac t                                                 21


<210> 511
<211> 10
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L3"

<400> 511
Gln Gln Phe Gly Arg Ser Pro Glu Leu Thr 
1               5                   10  


<210> 512
<211> 30
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L3"

<400> 512
cagcagtttg gtaggtcacc ggagctcact                                        30


<210> 513
<211> 354
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region"

<400> 513
caggtgcagc tacagcagtg gggcgcagga ctgttgaagc cttcggagac cctgtccctc       60

acctgcgctg tctatggtgg gtccttcagt ggttactact ggggctggat ccgccagccc      120

ccagggaagg ggctggagtg gattggggaa gtcaatcata gtggaacctc caattacaac      180

ccgtccctca cgagtcgagt caccatatca gtagacccgt ccaagaaaca gttgtccctg      240

aagctgaact ctgtgaccgc cgcggacacg gctgtctatt actgtgcgag agctccttgg      300

tatactcacg ccatggacgt ctggggccaa gggaccacgg tcaccgtctc ctca            354


<210> 514
<211> 118
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region"

<400> 514
Gln Val Gln Leu Gln Gln Trp Gly Ala Gly Leu Leu Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Ala Val Tyr Gly Gly Ser Phe Ser Gly Tyr 
            20                  25                  30          


Tyr Trp Gly Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Glu Val Asn His Ser Gly Thr Ser Asn Tyr Asn Pro Ser Leu Thr 
    50                  55                  60                  


Ser Arg Val Thr Ile Ser Val Asp Pro Ser Lys Lys Gln Leu Ser Leu 
65                  70                  75                  80  


Lys Leu Asn Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Ala Pro Trp Tyr Thr His Ala Met Asp Val Trp Gly Gln Gly Thr 
            100                 105                 110         


Thr Val Thr Val Ser Ser 
        115             


<210> 515
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H1"

<400> 515
Gly Ser Phe Ser Gly Tyr Tyr Trp Gly 
1               5                   


<210> 516
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H1"

<400> 516
gggtccttca gtggttacta ctggggc                                           27


<210> 517
<211> 16
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H2"

<400> 517
Glu Val Asn His Ser Gly Thr Ser Asn Tyr Asn Pro Ser Leu Thr Ser 
1               5                   10                  15      


<210> 518
<211> 48
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H2"

<400> 518
gaagtcaatc atagtggaac ctccaattac aacccgtccc tcacgagt                    48


<210> 519
<211> 12
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H3"

<400> 519
Ala Arg Ala Pro Trp Tyr Thr His Ala Met Asp Val 
1               5                   10          


<210> 520
<211> 36
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H3"

<400> 520
gcgagagctc cttggtatac tcacgccatg gacgtc                                 36


<210> 521
<211> 333
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region"

<400> 521
cagtctgtcc tgactcagcc tgcctccgtg tctgggtctc ctggacagtc gatcaccatc       60

tcctgcacta gaaccagcag tgacgttggt gcttatagtt atgtctcctg gtaccaacaa      120

cacccaggca aagcccccaa actcatgatt tatgatgtca ataatcggcc ctcaggggtt      180

tctaatcgct tctctggctc caagtctggc aacacggcct ccctgaccat ctctgggctc      240

caggctgagg acgaggctga ttattactgc agctcatata caaacagcaa cactctcggg      300

gtgttcggcg gagggaccaa gctgaccgtc cta                                   333


<210> 522
<211> 111
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region"

<400> 522
Gln Ser Val Leu Thr Gln Pro Ala Ser Val Ser Gly Ser Pro Gly Gln 
1               5                   10                  15      


Ser Ile Thr Ile Ser Cys Thr Arg Thr Ser Ser Asp Val Gly Ala Tyr 
            20                  25                  30          


Ser Tyr Val Ser Trp Tyr Gln Gln His Pro Gly Lys Ala Pro Lys Leu 
        35                  40                  45              


Met Ile Tyr Asp Val Asn Asn Arg Pro Ser Gly Val Ser Asn Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Asn Thr Ala Ser Leu Thr Ile Ser Gly Leu 
65                  70                  75                  80  


Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Ser Ser Tyr Thr Asn Ser 
                85                  90                  95      


Asn Thr Leu Gly Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 110     


<210> 523
<211> 14
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L1"

<400> 523
Thr Arg Thr Ser Ser Asp Val Gly Ala Tyr Ser Tyr Val Ser 
1               5                   10                  


<210> 524
<211> 42
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L1"

<400> 524
actagaacca gcagtgacgt tggtgcttat agttatgtct cc                          42


<210> 525
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L2"

<400> 525
Asp Val Asn Asn Arg Pro Ser 
1               5           


<210> 526
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L2"

<400> 526
gatgtcaata atcggccctc a                                                 21


<210> 527
<211> 11
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L3"

<400> 527
Ser Ser Tyr Thr Asn Ser Asn Thr Leu Gly Val 
1               5                   10      


<210> 528
<211> 33
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L3"

<400> 528
agctcatata caaacagcaa cactctcggg gtg                                    33


<210> 529
<211> 363
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region"

<400> 529
gaggtgcagc tgttggagtc tgggggactc gtggtacagc ctggggggtc cctgagactg       60

tcctgtgcag cctctggatt catctttgat gattatacca tgcactgggt ccgtcaagct      120

ccggggaagg gtctggagtg gatctctctt attagttggg atagtcttga cacatactat      180

gcaggctctg tgcagggccg cttcaccatc tccagagaca acagcagaaa ctccctctat      240

ctgcgaatga acagtctgag acctgaggac accgccttgt attactgtgc aaaaacaaag      300

tataggggta cttattacta ctttgactcg tggggccagg gaaccctggt caccgtctcc      360

tca                                                                    363


<210> 530
<211> 121
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region"

<400> 530
Glu Val Gln Leu Leu Glu Ser Gly Gly Leu Val Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ile Phe Asp Asp Tyr 
            20                  25                  30          


Thr Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Ser Leu Ile Ser Trp Asp Ser Leu Asp Thr Tyr Tyr Ala Gly Ser Val 
    50                  55                  60                  


Gln Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Arg Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Arg Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Leu Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Thr Lys Tyr Arg Gly Thr Tyr Tyr Tyr Phe Asp Ser Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120     


<210> 531
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H1"

<400> 531
Phe Ile Phe Asp Asp Tyr Thr Met His 
1               5                   


<210> 532
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H1"

<400> 532
ttcatctttg atgattatac catgcac                                           27


<210> 533
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H2"

<400> 533
Leu Ile Ser Trp Asp Ser Leu Asp Thr Tyr Tyr Ala Gly Ser Val Gln 
1               5                   10                  15      


Gly 
    


<210> 534
<211> 51
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H2"

<400> 534
cttattagtt gggatagtct tgacacatac tatgcaggct ctgtgcaggg c                51


<210> 535
<211> 14
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H3"

<400> 535
Ala Lys Thr Lys Tyr Arg Gly Thr Tyr Tyr Tyr Phe Asp Ser 
1               5                   10                  


<210> 536
<211> 42
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H3"

<400> 536
gcaaaaacaa agtatagggg tacttattac tactttgact cg                          42


<210> 537
<211> 324
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region"

<400> 537
gacatccggg tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga cagagtcacc       60

atcacttgcc aggcgagtca ggacattagc aactatttaa attggtatca gcagaaacca      120

gggaaagccc ctaagctcct gatctacgat gcatccaatt tggaaacagg ggtcccatca      180

aggttcagtg gacgtggatc tgggacagat tttactttca ccatcagcag cctgcagcct      240

gaagatattg caacatatta ctgtcaacaa tatgataatc tccctccggt cactttcggc      300

cctgggacca aggtggaaat caaa                                             324


<210> 538
<211> 108
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region"

<400> 538
Asp Ile Arg Val Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Gln Ala Ser Gln Asp Ile Ser Asn Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Asp Ala Ser Asn Leu Glu Thr Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Arg Gly Ser Gly Thr Asp Phe Thr Phe Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Ile Ala Thr Tyr Tyr Cys Gln Gln Tyr Asp Asn Leu Pro Pro 
                85                  90                  95      


Val Thr Phe Gly Pro Gly Thr Lys Val Glu Ile Lys 
            100                 105             


<210> 539
<211> 11
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L1"

<400> 539
Gln Ala Ser Gln Asp Ile Ser Asn Tyr Leu Asn 
1               5                   10      


<210> 540
<211> 33
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L1"

<400> 540
caggcgagtc aggacattag caactattta aat                                    33


<210> 541
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L2"

<400> 541
Asp Ala Ser Asn Leu Glu Thr 
1               5           


<210> 542
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L2"

<400> 542
gatgcatcca atttggaaac a                                                 21


<210> 543
<211> 10
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L3"

<400> 543
Gln Gln Tyr Asp Asn Leu Pro Pro Val Thr 
1               5                   10  


<210> 544
<211> 30
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L3"

<400> 544
caacaatatg ataatctccc tccggtcact                                        30


<210> 545
<211> 372
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region"

<400> 545
gaggtgcagc tgttggagtc tgggggaggc ctggtcaagc cgggggggtc cctgagactc       60

tcctgtgcag cctctggatt caccttcagt agttatggca tgcactgggt ccgccaggcg      120

ccagggaagg ggctagagtg ggtctcatcc attactgctg gtagtagtta catggactac      180

gcagactcag tgaagggccg attcaccgtc tccagagaca acggcaagaa ctcactgtac      240

ctgcaaatga acagcctgag agccgaggac acggctgtct acttctgtgc gagagaggac      300

tatgatagtc gtgtttatta ccttaagtgg ttcgacccct ggggccaggg aaccctggtc      360

accgtctcct ca                                                          372


<210> 546
<211> 124
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region"

<400> 546
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ser Ile Thr Ala Gly Ser Ser Tyr Met Asp Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Val Ser Arg Asp Asn Gly Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Phe Cys 
                85                  90                  95      


Ala Arg Glu Asp Tyr Asp Ser Arg Val Tyr Tyr Leu Lys Trp Phe Asp 
            100                 105                 110         


Pro Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 


<210> 547
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H1"

<400> 547
Phe Thr Phe Ser Ser Tyr Gly Met His 
1               5                   


<210> 548
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H1"

<400> 548
ttcaccttca gtagttatgg catgcac                                           27


<210> 549
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H2"

<400> 549
Ser Ile Thr Ala Gly Ser Ser Tyr Met Asp Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210> 550
<211> 51
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H2"

<400> 550
tccattactg ctggtagtag ttacatggac tacgcagact cagtgaaggg c                51


<210> 551
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H3"

<400> 551
Ala Arg Glu Asp Tyr Asp Ser Arg Val Tyr Tyr Leu Lys Trp Phe Asp 
1               5                   10                  15      


Pro 
    


<210> 552
<211> 51
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H3"

<400> 552
gcgagagagg actatgatag tcgtgtttat taccttaagt ggttcgaccc c                51


<210> 553
<211> 333
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region"

<400> 553
cagtctgtct tgacgcagcc gccctcagtg tctggggccc cagggcagag agtcaccatc       60

tcctgcactg ggagcagctc caacatcggg acaggttatg atgtacactg gtaccagcag      120

cttccaggat cagcccccaa actcctcatc tatggtaaca gcaatcggcc ctcaggggtc      180

cctgaccgat tctctgggtc caagtctggc acctcagcct ccctggccat cactgggctc      240

caggctgagg atgaggctga ctattattgc cagtcctatg acagcagtcg gagtggttat      300

gtcttcggaa ctgggaccaa gctgaccgtc cta                                   333


<210> 554
<211> 111
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region"

<400> 554
Gln Ser Val Leu Thr Gln Pro Pro Ser Val Ser Gly Ala Pro Gly Gln 
1               5                   10                  15      


Arg Val Thr Ile Ser Cys Thr Gly Ser Ser Ser Asn Ile Gly Thr Gly 
            20                  25                  30          


Tyr Asp Val His Trp Tyr Gln Gln Leu Pro Gly Ser Ala Pro Lys Leu 
        35                  40                  45              


Leu Ile Tyr Gly Asn Ser Asn Arg Pro Ser Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Thr Gly Leu 
65                  70                  75                  80  


Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Gln Ser Tyr Asp Ser Ser 
                85                  90                  95      


Arg Ser Gly Tyr Val Phe Gly Thr Gly Thr Lys Leu Thr Val Leu 
            100                 105                 110     


<210> 555
<211> 14
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L1"

<400> 555
Thr Gly Ser Ser Ser Asn Ile Gly Thr Gly Tyr Asp Val His 
1               5                   10                  


<210> 556
<211> 42
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L1"

<400> 556
actgggagca gctccaacat cgggacaggt tatgatgtac ac                          42


<210> 557
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L2"

<400> 557
Gly Asn Ser Asn Arg Pro Ser 
1               5           


<210> 558
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L2"

<400> 558
ggtaacagca atcggccctc a                                                 21


<210> 559
<211> 11
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L3"

<400> 559
Gln Ser Tyr Asp Ser Ser Arg Ser Gly Tyr Val 
1               5                   10      


<210> 560
<211> 33
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L3"

<400> 560
cagtcctatg acagcagtcg gagtggttat gtc                                    33


<210> 561
<211> 369
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region"

<400> 561
gaggtgcagc tggtggagtc tgggggcgcc ttggtaaagc cgggggggtc ccttagactc       60

tcctgtgtag gcactggact cactttcact actgcctaca tgagctgggc ccgccaggct      120

ccagggaagg ggctggagtg ggttggtcgc attaagagca aaagtgatgg tgggacaaca      180

gagtacccta cacccgtcaa aggcagattc accatctcaa gagatgaatc caaaaacacc      240

ctgtatctgc aaatgaacag cctgaaaatc gaggacacag ccgtctatta ttgtaccaca      300

gataggggga taacagctcg tcctatcttc gactcctggg gccagggaac cctggtcacc      360

gtctcctca                                                              369


<210> 562
<211> 123
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region"

<400> 562
Glu Val Gln Leu Val Glu Ser Gly Gly Ala Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Val Gly Thr Gly Leu Thr Phe Thr Thr Ala 
            20                  25                  30          


Tyr Met Ser Trp Ala Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Gly Arg Ile Lys Ser Lys Ser Asp Gly Gly Thr Thr Glu Tyr Pro Thr 
    50                  55                  60                  


Pro Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Glu Ser Lys Asn Thr 
65                  70                  75                  80  


Leu Tyr Leu Gln Met Asn Ser Leu Lys Ile Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Thr Thr Asp Arg Gly Ile Thr Ala Arg Pro Ile Phe Asp Ser 
            100                 105                 110         


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120             


<210> 563
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H1"

<400> 563
Leu Thr Phe Thr Thr Ala Tyr Met Ser 
1               5                   


<210> 564
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H1"

<400> 564
ctcactttca ctactgccta catgagc                                           27


<210> 565
<211> 19
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H2"

<400> 565
Arg Ile Lys Ser Lys Ser Asp Gly Gly Thr Thr Glu Tyr Pro Thr Pro 
1               5                   10                  15      


Val Lys Gly 
            


<210> 566
<211> 57
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H2"

<400> 566
cgcattaaga gcaaaagtga tggtgggaca acagagtacc ctacacccgt caaaggc          57


<210> 567
<211> 14
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H3"

<400> 567
Thr Thr Asp Arg Gly Ile Thr Ala Arg Pro Ile Phe Asp Ser 
1               5                   10                  


<210> 568
<211> 42
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H3"

<400> 568
accacagata gggggataac agctcgtcct atcttcgact cc                          42


<210> 569
<211> 333
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region"

<400> 569
cagtctgtct tgacgcagcc gccctcagtg tctggggccc tagggcggag ggtcaccatc       60

tcctgcactg ggagcagctc caacatcggg gcaggttatg atgtacattg gtacaggcaa      120

cttccaggaa cagcccccaa actcctcatt tatggtaaca ccaaacggcc ctcaggggtc      180

cctgaccgat tctctggctc caagtatgcc acctcagcct ccctggccat cactgggctc      240

caggctgagg atgacgctga ttattactgc cagtcctatg acggcggcct gagtggttat      300

gtcttcggaa ctggcaccca gctgaccgtc ctc                                   333


<210> 570
<211> 111
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region"

<400> 570
Gln Ser Val Leu Thr Gln Pro Pro Ser Val Ser Gly Ala Leu Gly Arg 
1               5                   10                  15      


Arg Val Thr Ile Ser Cys Thr Gly Ser Ser Ser Asn Ile Gly Ala Gly 
            20                  25                  30          


Tyr Asp Val His Trp Tyr Arg Gln Leu Pro Gly Thr Ala Pro Lys Leu 
        35                  40                  45              


Leu Ile Tyr Gly Asn Thr Lys Arg Pro Ser Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Tyr Ala Thr Ser Ala Ser Leu Ala Ile Thr Gly Leu 
65                  70                  75                  80  


Gln Ala Glu Asp Asp Ala Asp Tyr Tyr Cys Gln Ser Tyr Asp Gly Gly 
                85                  90                  95      


Leu Ser Gly Tyr Val Phe Gly Thr Gly Thr Gln Leu Thr Val Leu 
            100                 105                 110     


<210> 571
<211> 14
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L1"

<400> 571
Thr Gly Ser Ser Ser Asn Ile Gly Ala Gly Tyr Asp Val His 
1               5                   10                  


<210> 572
<211> 42
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L1"

<400> 572
actgggagca gctccaacat cggggcaggt tatgatgtac at                          42


<210> 573
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L2"

<400> 573
Gly Asn Thr Lys Arg Pro Ser 
1               5           


<210> 574
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L2"

<400> 574
ggtaacacca aacggccctc a                                                 21


<210> 575
<211> 11
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L3"

<400> 575
Gln Ser Tyr Asp Gly Gly Leu Ser Gly Tyr Val 
1               5                   10      


<210> 576
<211> 33
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L3"

<400> 576
cagtcctatg acggcggcct gagtggttat gtc                                    33


<210> 577
<211> 381
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region"

<400> 577
caggtccagc ttgtgcagtc tgggggaggc ctggtcaggc ctggggggtc cctgagactc       60

tcctgtgcag cctctggatt catgttcagt acctacagca tgaactggct ccgcacggtc      120

ccagggaagg ggctggagtg ggtctcatcc attagtggta gtagcagtca catatactac      180

gcagactcag tgaagggccg attcaccatc tccagagaca acaccaagaa ctcactgtat      240

ctgcaaatga acagcctgag acccgaagac acggctttat attactgtgc gagatatttt      300

ggtgactact cagggttggg gaactactac tactacggta tggacgtctg gggccagggg      360

accacggtca ccgtctcctc a                                                381


<210> 578
<211> 127
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region"

<400> 578
Gln Val Gln Leu Val Gln Ser Gly Gly Gly Leu Val Arg Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Met Phe Ser Thr Tyr 
            20                  25                  30          


Ser Met Asn Trp Leu Arg Thr Val Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ser Ile Ser Gly Ser Ser Ser His Ile Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Thr Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Leu Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Tyr Phe Gly Asp Tyr Ser Gly Leu Gly Asn Tyr Tyr Tyr Tyr 
            100                 105                 110         


Gly Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120                 125         


<210> 579
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H1"

<400> 579
Phe Met Phe Ser Thr Tyr Ser Met Asn 
1               5                   


<210> 580
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H1"

<400> 580
ttcatgttca gtacctacag catgaac                                           27


<210> 581
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H2"

<400> 581
Ser Ile Ser Gly Ser Ser Ser His Ile Tyr Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210> 582
<211> 51
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H2"

<400> 582
tccattagtg gtagtagcag tcacatatac tacgcagact cagtgaaggg c                51


<210> 583
<211> 20
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H3"

<400> 583
Ala Arg Tyr Phe Gly Asp Tyr Ser Gly Leu Gly Asn Tyr Tyr Tyr Tyr 
1               5                   10                  15      


Gly Met Asp Val 
            20  


<210> 584
<211> 60
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H3"

<400> 584
gcgagatatt ttggtgacta ctcagggttg gggaactact actactacgg tatggacgtc       60


<210> 585
<211> 333
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region"

<400> 585
gatattgtga tgacgcagtc tccagtctcc ctgcccgtca cccctggaga gccggcctcc       60

atctcctgca ggtctagtca gagcctcctg cattctaatg gaaacaacta tttggattgg      120

tacctgcaga ggccagggca gtctccacag ctcctcatct atttgggttc taatcgggcc      180

tccggggtcc ctgacaggtt cagtggcagt ggatcaggca cagattttac actgagaatc      240

agcagagtgg aggctgagga tgttggggtt tattactgca tgcaagctct acaaactcct      300

cgcttcggcg gagggaccaa ggtggaaatc aaa                                   333


<210> 586
<211> 111
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region"

<400> 586
Asp Ile Val Met Thr Gln Ser Pro Val Ser Leu Pro Val Thr Pro Gly 
1               5                   10                  15      


Glu Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Leu His Ser 
            20                  25                  30          


Asn Gly Asn Asn Tyr Leu Asp Trp Tyr Leu Gln Arg Pro Gly Gln Ser 
        35                  40                  45              


Pro Gln Leu Leu Ile Tyr Leu Gly Ser Asn Arg Ala Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Arg Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Met Gln Ala 
                85                  90                  95      


Leu Gln Thr Pro Arg Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105                 110     


<210> 587
<211> 16
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L1"

<400> 587
Arg Ser Ser Gln Ser Leu Leu His Ser Asn Gly Asn Asn Tyr Leu Asp 
1               5                   10                  15      


<210> 588
<211> 48
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L1"

<400> 588
aggtctagtc agagcctcct gcattctaat ggaaacaact atttggat                    48


<210> 589
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L2"

<400> 589
Leu Gly Ser Asn Arg Ala Ser 
1               5           


<210> 590
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L2"

<400> 590
ttgggttcta atcgggcctc c                                                 21


<210> 591
<211> 8
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L3"

<400> 591
Met Gln Ala Leu Gln Thr Pro Arg 
1               5               


<210> 592
<211> 24
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L3"

<400> 592
atgcaagctc tacaaactcc tcgc                                              24


<210> 593
<211> 390
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region"

<400> 593
gaggtgcagc tggtggagtc tgggggacac ttggtacagc ctggggggtc cctgagactc       60

tcctgtgcag cctctggatt caccttcagt agctatagta tgaactgggt ccgccaggct      120

ccagggaagg ggctggagtg gatttcatac attagtagta gtagtagtac catgtactac      180

gcagactctg tgaagggccg attcaccatg tccagagaca atgccaagaa ctcactgtat      240

ctgcaaatga acagcctgag agacgaggac acggctttgt attactgtgc gagagatttc      300

ccccctatta atctagcagc gacaacccga aactactact actatgttat ggacgtctgg      360

ggccaaggga ccacggtcac cgtctcctca                                       390


<210> 594
<211> 130
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region"

<400> 594
Glu Val Gln Leu Val Glu Ser Gly Gly His Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ser Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Ser Tyr Ile Ser Ser Ser Ser Ser Thr Met Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Met Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Asp Glu Asp Thr Ala Leu Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Phe Pro Pro Ile Asn Leu Ala Ala Thr Thr Arg Asn Tyr 
            100                 105                 110         


Tyr Tyr Tyr Val Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val 
        115                 120                 125             


Ser Ser 
    130 


<210> 595
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H1"

<400> 595
Phe Thr Phe Ser Ser Tyr Ser Met Asn 
1               5                   


<210> 596
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H1"

<400> 596
ttcaccttca gtagctatag tatgaac                                           27


<210> 597
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H2"

<400> 597
Tyr Ile Ser Ser Ser Ser Ser Thr Met Tyr Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210> 598
<211> 51
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H2"

<400> 598
tacattagta gtagtagtag taccatgtac tacgcagact ctgtgaaggg c                51


<210> 599
<211> 23
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H3"

<400> 599
Ala Arg Asp Phe Pro Pro Ile Asn Leu Ala Ala Thr Thr Arg Asn Tyr 
1               5                   10                  15      


Tyr Tyr Tyr Val Met Asp Val 
            20              


<210> 600
<211> 69
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H3"

<400> 600
gcgagagatt tcccccctat taatctagca gcgacaaccc gaaactacta ctactatgtt       60

atggacgtc                                                               69


<210> 601
<211> 321
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region"

<400> 601
gacatccagt tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga cagagtcacc       60

atcacttgcc gggcaagtca gagcattagc agctatttaa attggtatca gcagaaacca      120

gggaaagccc ctaacctcct aatctatgct acatccaatt tgaaaagtgg ggtcccatca      180

aggttcagtg gcagtggatc tgggacagat ttcactctca ccatcagcag tctgcaacct      240

gaagattttg caacttacta ctgtcaacag agttacagta cctcgtacac ttttggccag      300

gggaccaaag tggatatcaa a                                                321


<210> 602
<211> 107
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region"

<400> 602
Asp Ile Gln Leu Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Asn Leu Leu Ile 
        35                  40                  45              


Tyr Ala Thr Ser Asn Leu Lys Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Tyr Ser Thr Ser Tyr 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Asp Ile Lys 
            100                 105         


<210> 603
<211> 11
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L1"

<400> 603
Arg Ala Ser Gln Ser Ile Ser Ser Tyr Leu Asn 
1               5                   10      


<210> 604
<211> 33
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L1"

<400> 604
cgggcaagtc agagcattag cagctattta aat                                    33


<210> 605
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L2"

<400> 605
Ala Thr Ser Asn Leu Lys Ser 
1               5           


<210> 606
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L2"

<400> 606
gctacatcca atttgaaaag t                                                 21


<210> 607
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L3"

<400> 607
Gln Gln Ser Tyr Ser Thr Ser Tyr Thr 
1               5                   


<210> 608
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L3"

<400> 608
caacagagtt acagtacctc gtacact                                           27


<210> 609
<211> 375
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region"

<400> 609
gaggtgcagc tggtggagtc cggccctact ctggtgaaac ccacacagac cctcacgctg       60

acctgcacct tctctgggtt ctcactcacc actattggag tgggtgtggg ctggatccgt      120

cagcccccag gaaaggccct ggagtttctt ggaatcgttt attgggatga tgataagcgg      180

tacagcccat ctctgaagag caggctcacc atcaccaagg acacctccaa aaaccaggtg      240

gtccttacga tgaccacgtt ggcccctgag gacacaggca catattactg tacatacgcc      300

cgctatagca gtgccttgtt cgggggttac tactttcact cgtggggcca gggaaccctg      360

gtcaccgtct cctca                                                       375


<210> 610
<211> 125
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region"

<400> 610
Glu Val Gln Leu Val Glu Ser Gly Pro Thr Leu Val Lys Pro Thr Gln 
1               5                   10                  15      


Thr Leu Thr Leu Thr Cys Thr Phe Ser Gly Phe Ser Leu Thr Thr Ile 
            20                  25                  30          


Gly Val Gly Val Gly Trp Ile Arg Gln Pro Pro Gly Lys Ala Leu Glu 
        35                  40                  45              


Phe Leu Gly Ile Val Tyr Trp Asp Asp Asp Lys Arg Tyr Ser Pro Ser 
    50                  55                  60                  


Leu Lys Ser Arg Leu Thr Ile Thr Lys Asp Thr Ser Lys Asn Gln Val 
65                  70                  75                  80  


Val Leu Thr Met Thr Thr Leu Ala Pro Glu Asp Thr Gly Thr Tyr Tyr 
                85                  90                  95      


Cys Thr Tyr Ala Arg Tyr Ser Ser Ala Leu Phe Gly Gly Tyr Tyr Phe 
            100                 105                 110         


His Ser Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125 


<210> 611
<211> 11
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H1"

<400> 611
Phe Ser Leu Thr Thr Ile Gly Val Gly Val Gly 
1               5                   10      


<210> 612
<211> 33
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H1"

<400> 612
ttctcactca ccactattgg agtgggtgtg ggc                                    33


<210> 613
<211> 16
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H2"

<400> 613
Ile Val Tyr Trp Asp Asp Asp Lys Arg Tyr Ser Pro Ser Leu Lys Ser 
1               5                   10                  15      


<210> 614
<211> 48
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H2"

<400> 614
atcgtttatt gggatgatga taagcggtac agcccatctc tgaagagc                    48


<210> 615
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H3"

<400> 615
Thr Tyr Ala Arg Tyr Ser Ser Ala Leu Phe Gly Gly Tyr Tyr Phe His 
1               5                   10                  15      


Ser 
    


<210> 616
<211> 51
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H3"

<400> 616
acatacgccc gctatagcag tgccttgttc gggggttact actttcactc g                51


<210> 617
<211> 327
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region"

<400> 617
cagtctgtcc tgacgcagcc gccctcggtg tcagtggccc caggacagac ggccaagatt       60

acctgtgggg gaaacgacat tggaagtaga agtgtgcact ggtaccagca gaagccaggc      120

caggcccctg tgctggtcgt ctatgataat agcgaccggc cctcagggat ccctgaacga      180

ttctctggct ccaattctgg agacacggcc accctgacca tcagcagggt cgaagccggg      240

gatgaggccg tctattactg tcaggtgtgg gagagtagtg gtgatcatcc gaggatattc      300

ggcggaggga ccaagctcac cgtccta                                          327


<210> 618
<211> 109
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region"

<400> 618
Gln Ser Val Leu Thr Gln Pro Pro Ser Val Ser Val Ala Pro Gly Gln 
1               5                   10                  15      


Thr Ala Lys Ile Thr Cys Gly Gly Asn Asp Ile Gly Ser Arg Ser Val 
            20                  25                  30          


His Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Val Leu Val Val Tyr 
        35                  40                  45              


Asp Asn Ser Asp Arg Pro Ser Gly Ile Pro Glu Arg Phe Ser Gly Ser 
    50                  55                  60                  


Asn Ser Gly Asp Thr Ala Thr Leu Thr Ile Ser Arg Val Glu Ala Gly 
65                  70                  75                  80  


Asp Glu Ala Val Tyr Tyr Cys Gln Val Trp Glu Ser Ser Gly Asp His 
                85                  90                  95      


Pro Arg Ile Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 


<210> 619
<211> 11
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L1"

<400> 619
Gly Gly Asn Asp Ile Gly Ser Arg Ser Val His 
1               5                   10      


<210> 620
<211> 33
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L1"

<400> 620
gggggaaacg acattggaag tagaagtgtg cac                                    33


<210> 621
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L2"

<400> 621
Asp Asn Ser Asp Arg Pro Ser 
1               5           


<210> 622
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L2"

<400> 622
gataatagcg accggccctc a                                                 21


<210> 623
<211> 12
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L3"

<400> 623
Gln Val Trp Glu Ser Ser Gly Asp His Pro Arg Ile 
1               5                   10          


<210> 624
<211> 36
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L3"

<400> 624
caggtgtggg agagtagtgg tgatcatccg aggata                                 36


<210> 625
<211> 369
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region"

<400> 625
gaggtgcagc tggtggagtc tgggggcgcc ctggtaaagc cgggggggtc ccttagactc       60

tcctgtgtag gcactggact cactttcact actgcctaca tgagctgggc ccgccaggct      120

ccagggaagg ggctggagtg ggttggtcgt attctgagca aaagtgatgg tgggacaaca      180

gactacccta cacccgtcaa aggcagattc accatctcaa gagatgaatc taaaaacacc      240

ctgtatctgc aaatgaacag cctgaaaatc gaggacacag ccgtctatta ttgtaccaca      300

gataggggga taacagctcg tcctatcttc gactcctggg gccagggaac cctggtcacc      360

gtctcctca                                                              369


<210> 626
<211> 123
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region"

<400> 626
Glu Val Gln Leu Val Glu Ser Gly Gly Ala Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Val Gly Thr Gly Leu Thr Phe Thr Thr Ala 
            20                  25                  30          


Tyr Met Ser Trp Ala Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Gly Arg Ile Leu Ser Lys Ser Asp Gly Gly Thr Thr Asp Tyr Pro Thr 
    50                  55                  60                  


Pro Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Glu Ser Lys Asn Thr 
65                  70                  75                  80  


Leu Tyr Leu Gln Met Asn Ser Leu Lys Ile Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Thr Thr Asp Arg Gly Ile Thr Ala Arg Pro Ile Phe Asp Ser 
            100                 105                 110         


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120             


<210> 627
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H1"

<400> 627
Leu Thr Phe Thr Thr Ala Tyr Met Ser 
1               5                   


<210> 628
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H1"

<400> 628
ctcactttca ctactgccta catgagc                                           27


<210> 629
<211> 19
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H2"

<400> 629
Arg Ile Leu Ser Lys Ser Asp Gly Gly Thr Thr Asp Tyr Pro Thr Pro 
1               5                   10                  15      


Val Lys Gly 
            


<210> 630
<211> 57
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H2"

<400> 630
cgtattctga gcaaaagtga tggtgggaca acagactacc ctacacccgt caaaggc          57


<210> 631
<211> 14
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H3"

<400> 631
Thr Thr Asp Arg Gly Ile Thr Ala Arg Pro Ile Phe Asp Ser 
1               5                   10                  


<210> 632
<211> 42
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H3"

<400> 632
accacagata gggggataac agctcgtcct atcttcgact cc                          42


<210> 633
<211> 333
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region"

<400> 633
cagtctgtgc tgacgcagcc gccctcagtg tctggggccc tagggcggag ggtcaccatc       60

tcctgcactg ggagcagctc caacatcggg gcaggttatg atgtacattg gtacaggcaa      120

cttccaggaa cagcccccaa actcctcatt tatggtaaca ccaaacggcc ctcaggggtc      180

cctgaccgat tctctggctc caagtatgcc acctcagcct ccctggccat cactgggctc      240

caggctgacg atgacgctga ttattactgc cagtcctatg acggcggcct gagtggttat      300

gtcttcggaa ctgggaccaa ggtcaccgtc cta                                   333


<210> 634
<211> 111
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region"

<400> 634
Gln Ser Val Leu Thr Gln Pro Pro Ser Val Ser Gly Ala Leu Gly Arg 
1               5                   10                  15      


Arg Val Thr Ile Ser Cys Thr Gly Ser Ser Ser Asn Ile Gly Ala Gly 
            20                  25                  30          


Tyr Asp Val His Trp Tyr Arg Gln Leu Pro Gly Thr Ala Pro Lys Leu 
        35                  40                  45              


Leu Ile Tyr Gly Asn Thr Lys Arg Pro Ser Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Tyr Ala Thr Ser Ala Ser Leu Ala Ile Thr Gly Leu 
65                  70                  75                  80  


Gln Ala Asp Asp Asp Ala Asp Tyr Tyr Cys Gln Ser Tyr Asp Gly Gly 
                85                  90                  95      


Leu Ser Gly Tyr Val Phe Gly Thr Gly Thr Lys Val Thr Val Leu 
            100                 105                 110     


<210> 635
<211> 14
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L1"

<400> 635
Thr Gly Ser Ser Ser Asn Ile Gly Ala Gly Tyr Asp Val His 
1               5                   10                  


<210> 636
<211> 42
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L1"

<400> 636
actgggagca gctccaacat cggggcaggt tatgatgtac at                          42


<210> 637
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L2"

<400> 637
Gly Asn Thr Lys Arg Pro Ser 
1               5           


<210> 638
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L2"

<400> 638
ggtaacacca aacggccctc a                                                 21


<210> 639
<211> 11
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L3"

<400> 639
Gln Ser Tyr Asp Gly Gly Leu Ser Gly Tyr Val 
1               5                   10      


<210> 640
<211> 33
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L3"

<400> 640
cagtcctatg acggcggcct gagtggttat gtc                                    33


<210> 641
<211> 372
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region"

<400> 641
caggtccagc tggtgcagtc tgggggaggc ctggtcaagc ctggggggtc cctgagactc       60

tcctgtgcag gctctggatt caccttcagt agctataccc tgaactgggt ccgccaggct      120

ccagggaagg ggctggagtg ggtctcatcc attagtagta gtagtactta catatactac      180

gcagactcag tgaagggccg attcaccatc tccagagaca acgccaagaa ctcactgcat      240

ctgcaaatga acagcctgag agccgaggac acggctgtgt attattgtgc gagagctgac      300

tatgatagaa gtgtttatca cctcaattgg ttcgacccct ggggccaggg aaccctggtc      360

accgtctcct ca                                                          372


<210> 642
<211> 124
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region"

<400> 642
Gln Val Gln Leu Val Gln Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Gly Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Thr Leu Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ser Ile Ser Ser Ser Ser Thr Tyr Ile Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu His 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ala Asp Tyr Asp Arg Ser Val Tyr His Leu Asn Trp Phe Asp 
            100                 105                 110         


Pro Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 


<210> 643
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H1"

<400> 643
Phe Thr Phe Ser Ser Tyr Thr Leu Asn 
1               5                   


<210> 644
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H1"

<400> 644
ttcaccttca gtagctatac cctgaac                                           27


<210> 645
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H2"

<400> 645
Ser Ile Ser Ser Ser Ser Thr Tyr Ile Tyr Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210> 646
<211> 51
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H2"

<400> 646
tccattagta gtagtagtac ttacatatac tacgcagact cagtgaaggg c                51


<210> 647
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H3"

<400> 647
Ala Arg Ala Asp Tyr Asp Arg Ser Val Tyr His Leu Asn Trp Phe Asp 
1               5                   10                  15      


Pro 
    


<210> 648
<211> 51
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H3"

<400> 648
gcgagagctg actatgatag aagtgtttat cacctcaatt ggttcgaccc c                51


<210> 649
<211> 336
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region"

<400> 649
cagtctgtgt tgacgcagcc gccctcagtg tctggggccc cagggcagag ggtcaccatc       60

tcctgcactg ggagcagctc caacatcggg gcaggttatg atgtacactg gtaccagcaa      120

cttccaggag cagcccccaa actcctcatc tatggtaaca ccaatcggcc ctcaggggtc      180

cctgaccgat tttctggctc caagtctggc acctcagcct ccctggccat cactgggctc      240

caggctgacg atgaggctga ttattactgc cagtcctatg acagcagcct gagtggcact      300

tgggtgttcg gcggagggac caagctcacc gtccta                                336


<210> 650
<211> 112
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region"

<400> 650
Gln Ser Val Leu Thr Gln Pro Pro Ser Val Ser Gly Ala Pro Gly Gln 
1               5                   10                  15      


Arg Val Thr Ile Ser Cys Thr Gly Ser Ser Ser Asn Ile Gly Ala Gly 
            20                  25                  30          


Tyr Asp Val His Trp Tyr Gln Gln Leu Pro Gly Ala Ala Pro Lys Leu 
        35                  40                  45              


Leu Ile Tyr Gly Asn Thr Asn Arg Pro Ser Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Thr Gly Leu 
65                  70                  75                  80  


Gln Ala Asp Asp Glu Ala Asp Tyr Tyr Cys Gln Ser Tyr Asp Ser Ser 
                85                  90                  95      


Leu Ser Gly Thr Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 110         


<210> 651
<211> 14
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L1"

<400> 651
Thr Gly Ser Ser Ser Asn Ile Gly Ala Gly Tyr Asp Val His 
1               5                   10                  


<210> 652
<211> 42
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L1"

<400> 652
actgggagca gctccaacat cggggcaggt tatgatgtac ac                          42


<210> 653
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L2"

<400> 653
Gly Asn Thr Asn Arg Pro Ser 
1               5           


<210> 654
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L2"

<400> 654
ggtaacacca atcggccctc a                                                 21


<210> 655
<211> 12
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L3"

<400> 655
Gln Ser Tyr Asp Ser Ser Leu Ser Gly Thr Trp Val 
1               5                   10          


<210> 656
<211> 36
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L3"

<400> 656
cagtcctatg acagcagcct gagtggcact tgggtg                                 36


<210> 657
<211> 372
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region"

<400> 657
gaggtgcagc tgttggagtc tgggggaggc ttggtacagc cagggcggtc cctgagactc       60

tcttgttcag gttctggatt cacctttggg gattatgctc tgagctgggt ccgccaggct      120

ccagggaagg ggctggagtg ggtaggtttc attagaagca aagcctatgg tgggacaaca      180

gaatacgccg cgtctgtgaa aggcagattc accatctcaa gagatgattc caaaagcatc      240

gcctatctgc aaatgaacag cctgaaaacc gaggacacag ccgtgtatta ctgtactatg      300

gctgtagtgg tgccaggtgc tacagatgct tttgatatct ggggccaagg gacaatggtc      360

accgtctctt ca                                                          372


<210> 658
<211> 124
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region"

<400> 658
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ser Gly Ser Gly Phe Thr Phe Gly Asp Tyr 
            20                  25                  30          


Ala Leu Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Gly Phe Ile Arg Ser Lys Ala Tyr Gly Gly Thr Thr Glu Tyr Ala Ala 
    50                  55                  60                  


Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Ser Ile 
65                  70                  75                  80  


Ala Tyr Leu Gln Met Asn Ser Leu Lys Thr Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Thr Met Ala Val Val Val Pro Gly Ala Thr Asp Ala Phe Asp 
            100                 105                 110         


Ile Trp Gly Gln Gly Thr Met Val Thr Val Ser Ser 
        115                 120                 


<210> 659
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H1"

<400> 659
Phe Thr Phe Gly Asp Tyr Ala Leu Ser 
1               5                   


<210> 660
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H1"

<400> 660
ttcacctttg gggattatgc tctgagc                                           27


<210> 661
<211> 19
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H2"

<400> 661
Phe Ile Arg Ser Lys Ala Tyr Gly Gly Thr Thr Glu Tyr Ala Ala Ser 
1               5                   10                  15      


Val Lys Gly 
            


<210> 662
<211> 57
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H2"

<400> 662
ttcattagaa gcaaagccta tggtgggaca acagaatacg ccgcgtctgt gaaaggc          57


<210> 663
<211> 15
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H3"

<400> 663
Thr Met Ala Val Val Val Pro Gly Ala Thr Asp Ala Phe Asp Ile 
1               5                   10                  15  


<210> 664
<211> 45
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H3"

<400> 664
actatggctg tagtggtgcc aggtgctaca gatgcttttg atatc                       45


<210> 665
<211> 333
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region"

<400> 665
aattttatgc tgactcagcc ccactctgtg tcggagtctc cggggaagac ggtaaccatc       60

tcctgtaccc gcagcagtgg cagcattgcc agcgactatg tgcagtggtt ccagcagcgc      120

ccgggcagtt cccccgccac tgtgatctat caggataacc aaagaccctc tggggtccct      180

gatcggttct ctggctccat cgacacctcc tccaactctg cctccctcac catctctgga      240

ctgaagactg aggacgaggc tgactactac tgtcactctt atgatagtag caatccttgg      300

gtgttcggcg gagggaccaa gctcaccgtc cta                                   333


<210> 666
<211> 111
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region"

<400> 666
Asn Phe Met Leu Thr Gln Pro His Ser Val Ser Glu Ser Pro Gly Lys 
1               5                   10                  15      


Thr Val Thr Ile Ser Cys Thr Arg Ser Ser Gly Ser Ile Ala Ser Asp 
            20                  25                  30          


Tyr Val Gln Trp Phe Gln Gln Arg Pro Gly Ser Ser Pro Ala Thr Val 
        35                  40                  45              


Ile Tyr Gln Asp Asn Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Ile Asp Thr Ser Ser Asn Ser Ala Ser Leu Thr Ile Ser Gly 
65                  70                  75                  80  


Leu Lys Thr Glu Asp Glu Ala Asp Tyr Tyr Cys His Ser Tyr Asp Ser 
                85                  90                  95      


Ser Asn Pro Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 110     


<210> 667
<211> 13
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L1"

<400> 667
Thr Arg Ser Ser Gly Ser Ile Ala Ser Asp Tyr Val Gln 
1               5                   10              


<210> 668
<211> 39
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L1"

<400> 668
acccgcagca gtggcagcat tgccagcgac tatgtgcag                              39


<210> 669
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L2"

<400> 669
Gln Asp Asn Gln Arg Pro Ser 
1               5           


<210> 670
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L2"

<400> 670
caggataacc aaagaccctc t                                                 21


<210> 671
<211> 10
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L3"

<400> 671
His Ser Tyr Asp Ser Ser Asn Pro Trp Val 
1               5                   10  


<210> 672
<211> 30
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L3"

<400> 672
cactcttatg atagtagcaa tccttgggtg                                        30


<210> 673
<211> 369
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region"

<400> 673
gaggtgcagc tggtggagtc cggaggaggc ttgatccagc cgggggggtc cctgagactc       60

tcctgtgcag tctctgggtt cagcgtcagc agcaactata taagttgggt ccgccagcct      120

ccagggaagg ggctggagtg ggtctcagtt agttatagta gtggtgtcac agactacgca      180

gactccgtga agggccgatt caccacctcc agagacaact ccaagaacac gctgtatctt      240

caaatgaaca gcctgagagg cgaagacacg gccgtctatt actgtgcgag agagttggtg      300

ccaaatttct atgaaagtca tggttatttt tccgtgtggg gccagggaac cctggtcacc      360

gtctcctca                                                              369


<210> 674
<211> 123
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region"

<400> 674
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Ile Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Val Ser Gly Phe Ser Val Ser Ser Asn 
            20                  25                  30          


Tyr Ile Ser Trp Val Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Val Ser Tyr Ser Ser Gly Val Thr Asp Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Thr Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Gly Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Glu Leu Val Pro Asn Phe Tyr Glu Ser His Gly Tyr Phe Ser Val 
            100                 105                 110         


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120             


<210> 675
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H1"

<400> 675
Phe Ser Val Ser Ser Asn Tyr Ile Ser 
1               5                   


<210> 676
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H1"

<400> 676
ttcagcgtca gcagcaacta tataagt                                           27


<210> 677
<211> 16
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H2"

<400> 677
Val Ser Tyr Ser Ser Gly Val Thr Asp Tyr Ala Asp Ser Val Lys Gly 
1               5                   10                  15      


<210> 678
<211> 48
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H2"

<400> 678
gttagttata gtagtggtgt cacagactac gcagactccg tgaagggc                    48


<210> 679
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H3"

<400> 679
Ala Arg Glu Leu Val Pro Asn Phe Tyr Glu Ser His Gly Tyr Phe Ser 
1               5                   10                  15      


Val 
    


<210> 680
<211> 51
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H3"

<400> 680
gcgagagagt tggtgccaaa tttctatgaa agtcatggtt atttttccgt g                51


<210> 681
<211> 321
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region"

<400> 681
gatattgtga tgactcagtc tccaggcacc ctgtctttgt ctccagggga aagagccacc       60

ctctcctgca gggccagtca gagagttgac agcagctact tagcctggta ccagcagaaa      120

cctggccagg ctcccaggct cctcatctat ggtggatcca gcagggccac tggcatccca      180

gacaggttca gtggcagtgg gtctgggaca gacttcactc tcaccatcag caggctggag      240

cctgaagatt ttgcgttgta ttactgtcag cagtatggtt tctcacagac gttcggccaa      300

gggaccaagg tggagatcaa a                                                321


<210> 682
<211> 107
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region"

<400> 682
Asp Ile Val Met Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Arg Val Asp Ser Ser 
            20                  25                  30          


Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu 
        35                  40                  45              


Ile Tyr Gly Gly Ser Ser Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu 
65                  70                  75                  80  


Pro Glu Asp Phe Ala Leu Tyr Tyr Cys Gln Gln Tyr Gly Phe Ser Gln 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210> 683
<211> 12
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L1"

<400> 683
Arg Ala Ser Gln Arg Val Asp Ser Ser Tyr Leu Ala 
1               5                   10          


<210> 684
<211> 36
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L1"

<400> 684
agggccagtc agagagttga cagcagctac ttagcc                                 36


<210> 685
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L2"

<400> 685
Gly Gly Ser Ser Arg Ala Thr 
1               5           


<210> 686
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L2"

<400> 686
ggtggatcca gcagggccac t                                                 21


<210> 687
<211> 8
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L3"

<400> 687
Gln Gln Tyr Gly Phe Ser Gln Thr 
1               5               


<210> 688
<211> 24
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L3"

<400> 688
cagcagtatg gtttctcaca gacg                                              24


<210> 689
<211> 378
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region"

<400> 689
gaggtgcagc tgttggagac tgggggaggc ttggttaagc cgggggggtc cctgagactc       60

tcctgtgaag ccactggatt cactttcagc gactttgcca tgagctgggt ccgccaggct      120

ccagggaagg ggctggagtg ggtctcactg attaaaagta gtgattatcc atactatgca      180

gactccgtga ggggccgctt caccatctcc agagacaatt ccaagaacac cctgtatctg      240

cgaatggaca acctgagagc cgacgacacg gccgtgtatt actgtgccaa ggacgccgat      300

ttttggagtg gtgaggccta caatggaggg tacaactttg actcctgggg ccagggaacc      360

ctggtcaccg tctcctca                                                    378


<210> 690
<211> 126
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region"

<400> 690
Glu Val Gln Leu Leu Glu Thr Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Glu Ala Thr Gly Phe Thr Phe Ser Asp Phe 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Leu Ile Lys Ser Ser Asp Tyr Pro Tyr Tyr Ala Asp Ser Val Arg 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu 
65                  70                  75                  80  


Arg Met Asp Asn Leu Arg Ala Asp Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Lys Asp Ala Asp Phe Trp Ser Gly Glu Ala Tyr Asn Gly Gly Tyr Asn 
            100                 105                 110         


Phe Asp Ser Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125     


<210> 691
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H1"

<400> 691
Phe Thr Phe Ser Asp Phe Ala Met Ser 
1               5                   


<210> 692
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H1"

<400> 692
ttcactttca gcgactttgc catgagc                                           27


<210> 693
<211> 16
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H2"

<400> 693
Leu Ile Lys Ser Ser Asp Tyr Pro Tyr Tyr Ala Asp Ser Val Arg Gly 
1               5                   10                  15      


<210> 694
<211> 48
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H2"

<400> 694
ctgattaaaa gtagtgatta tccatactat gcagactccg tgaggggc                    48


<210> 695
<211> 20
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H3"

<400> 695
Ala Lys Asp Ala Asp Phe Trp Ser Gly Glu Ala Tyr Asn Gly Gly Tyr 
1               5                   10                  15      


Asn Phe Asp Ser 
            20  


<210> 696
<211> 60
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H3"

<400> 696
gccaaggacg ccgatttttg gagtggtgag gcctacaatg gagggtacaa ctttgactcc       60


<210> 697
<211> 324
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region"

<400> 697
gaaattgtat tgacacagtc tccagccacc ctgtctgtct ctccagggga aagagccacc       60

ctctcctgca gggccagtca gagtattggc accaacttgg cctggtacca gcaaaaacct      120

ggccaggctc cccggctcct catctttggt gcctcaacca gggccacggg tatcccagcc      180

aggttcactg gcagtgggtc tgggacagag ttcactctca ccatcggcag cctccagtct      240

gaagattttg cagtttatta ctgtcagcag tacaatcagt ggcctccgat cactttcggc      300

ggagggacca aggtggaaat caaa                                             324


<210> 698
<211> 108
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region"

<400> 698
Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Val Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Ile Gly Thr Asn 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 
        35                  40                  45              


Phe Gly Ala Ser Thr Arg Ala Thr Gly Ile Pro Ala Arg Phe Thr Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Gly Ser Leu Gln Ser 
65                  70                  75                  80  


Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Asn Gln Trp Pro Pro 
                85                  90                  95      


Ile Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105             


<210> 699
<211> 11
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L1"

<400> 699
Arg Ala Ser Gln Ser Ile Gly Thr Asn Leu Ala 
1               5                   10      


<210> 700
<211> 33
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L1"

<400> 700
agggccagtc agagtattgg caccaacttg gcc                                    33


<210> 701
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L2"

<400> 701
Gly Ala Ser Thr Arg Ala Thr 
1               5           


<210> 702
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L2"

<400> 702
ggtgcctcaa ccagggccac g                                                 21


<210> 703
<211> 10
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L3"

<400> 703
Gln Gln Tyr Asn Gln Trp Pro Pro Ile Thr 
1               5                   10  


<210> 704
<211> 30
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L3"

<400> 704
cagcagtaca atcagtggcc tccgatcact                                        30


<210> 705
<211> 372
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region"

<400> 705
gaggtgcagc tgttggagtc tgggggaggc gtggtccagc ctgggaagtc cctgagactc       60

tcctgtgtag cctctggatt caccttcggt gactatggca tgcactgggt ccgccaggct      120

ccaggcaagg ggctggagtg ggtggcagtt atatcagatg gtggaagcac taaatactat      180

gcagactccg tgaagggccg attcaccatc gccagagaca attccaagaa cacgctgaat      240

ctgcaaatga acagcctgag agctgaggac acggctgtgt attactgtgc gaaagatttg      300

gcttggattt ttggactggg tgcttcatat atggacgtct ggggccaagg gaccctggtc      360

accgtctcct ca                                                          372


<210> 706
<211> 124
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region"

<400> 706
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Val Val Gln Pro Gly Lys 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Val Ala Ser Gly Phe Thr Phe Gly Asp Tyr 
            20                  25                  30          


Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Val Ile Ser Asp Gly Gly Ser Thr Lys Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ala Arg Asp Asn Ser Lys Asn Thr Leu Asn 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Asp Leu Ala Trp Ile Phe Gly Leu Gly Ala Ser Tyr Met Asp 
            100                 105                 110         


Val Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 


<210> 707
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H1"

<400> 707
Phe Thr Phe Gly Asp Tyr Gly Met His 
1               5                   


<210> 708
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H1"

<400> 708
ttcaccttcg gtgactatgg catgcac                                           27


<210> 709
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H2"

<400> 709
Val Ile Ser Asp Gly Gly Ser Thr Lys Tyr Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210> 710
<211> 51
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H2"

<400> 710
gttatatcag atggtggaag cactaaatac tatgcagact ccgtgaaggg c                51


<210> 711
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H3"

<400> 711
Ala Lys Asp Leu Ala Trp Ile Phe Gly Leu Gly Ala Ser Tyr Met Asp 
1               5                   10                  15      


Val 
    


<210> 712
<211> 51
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H3"

<400> 712
gcgaaagatt tggcttggat ttttggactg ggtgcttcat atatggacgt c                51


<210> 713
<211> 330
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region"

<400> 713
gacatccagt tgacccagtc tccaggcacc ctgtctttgt ctccagggga aagagccacc       60

ctctcctgca gggccagtca gactgttagt agcagctact tagcctggta ccagcagaaa      120

cctggccagg ctcccaggct cctcatctat gatgcatcca gcagggccac tggcatccca      180

gacaggttca gtggcagtgg gtctgggaca gacttcactc tcaccatcag cagactggag      240

cctgaagatt ttgcagtgta ttactgtcag cagtatggta gctcaccttt cgggctcact      300

ttcggcggag ggaccaaggt ggaaatcaaa                                       330


<210> 714
<211> 110
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region"

<400> 714
Asp Ile Gln Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Thr Val Ser Ser Ser 
            20                  25                  30          


Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu 
        35                  40                  45              


Ile Tyr Asp Ala Ser Ser Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu 
65                  70                  75                  80  


Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Gly Ser Ser Pro 
                85                  90                  95      


Phe Gly Leu Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105                 110 


<210> 715
<211> 12
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L1"

<400> 715
Arg Ala Ser Gln Thr Val Ser Ser Ser Tyr Leu Ala 
1               5                   10          


<210> 716
<211> 36
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L1"

<400> 716
agggccagtc agactgttag tagcagctac ttagcc                                 36


<210> 717
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L2"

<400> 717
Asp Ala Ser Ser Arg Ala Thr 
1               5           


<210> 718
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L2"

<400> 718
gatgcatcca gcagggccac t                                                 21


<210> 719
<211> 11
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L3"

<400> 719
Gln Gln Tyr Gly Ser Ser Pro Phe Gly Leu Thr 
1               5                   10      


<210> 720
<211> 33
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L3"

<400> 720
cagcagtatg gtagctcacc tttcgggctc act                                    33


<210> 721
<211> 369
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region"

<400> 721
caggtccagc tggtgcagtc tgggggaggc ttggtacagc cgggggggtc cctgcgactc       60

tcctgtgcag cctctggatt cacctttggg agacatgcca tgacgtgggt ccgccaggct      120

ccagggaagg ggctggagtg ggtcgcaggc attactgcta ctggggaccc cacatactac      180

ccagactccg tgaagggccg gttcgccgtc tccagagaca actcccggaa cacgctttat      240

ctgcaaatgg acagtctgag agtcgaggac acggccctat attactgtgc gagaagttgg      300

gatgactacg gtgacctgga ctggtacttc gctctctggg gccgtggcac aatggtcacc      360

gtctcttca                                                              369


<210> 722
<211> 123
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region"

<400> 722
Gln Val Gln Leu Val Gln Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Gly Arg His 
            20                  25                  30          


Ala Met Thr Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Gly Ile Thr Ala Thr Gly Asp Pro Thr Tyr Tyr Pro Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Ala Val Ser Arg Asp Asn Ser Arg Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asp Ser Leu Arg Val Glu Asp Thr Ala Leu Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ser Trp Asp Asp Tyr Gly Asp Leu Asp Trp Tyr Phe Ala Leu 
            100                 105                 110         


Trp Gly Arg Gly Thr Met Val Thr Val Ser Ser 
        115                 120             


<210> 723
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H1"

<400> 723
Phe Thr Phe Gly Arg His Ala Met Thr 
1               5                   


<210> 724
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H1"

<400> 724
ttcacctttg ggagacatgc catgacg                                           27


<210> 725
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H2"

<400> 725
Gly Ile Thr Ala Thr Gly Asp Pro Thr Tyr Tyr Pro Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210> 726
<211> 51
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H2"

<400> 726
ggcattactg ctactgggga ccccacatac tacccagact ccgtgaaggg c                51


<210> 727
<211> 16
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H3"

<400> 727
Ala Arg Ser Trp Asp Asp Tyr Gly Asp Leu Asp Trp Tyr Phe Ala Leu 
1               5                   10                  15      


<210> 728
<211> 48
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H3"

<400> 728
gcgagaagtt gggatgacta cggtgacctg gactggtact tcgctctc                    48


<210> 729
<211> 324
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region"

<400> 729
gaaattgtga tgacacagtc tccagccatc ctgtctgtgt ctccagggga aagagccacc       60

ctctcctgca gggccagtca gagtgttagc agcagcttgg cctggtacca gcagaaacct      120

ggccaggctc ctaggctcct catctacggt gcatccacca gggccactgg tatcccaccc      180

cggttcagtg gcagtgggtc tgggacacaa ttcactctca ccatcagcag cctgcagtct      240

gaagatgttg cagtatatta ctgtcagcag tatagtgact ggcctccgct cactttcggc      300

ggggggacca aggtggaaat caaa                                             324


<210> 730
<211> 108
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region"

<400> 730
Glu Ile Val Met Thr Gln Ser Pro Ala Ile Leu Ser Val Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Ser 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 
        35                  40                  45              


Tyr Gly Ala Ser Thr Arg Ala Thr Gly Ile Pro Pro Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Gln Phe Thr Leu Thr Ile Ser Ser Leu Gln Ser 
65                  70                  75                  80  


Glu Asp Val Ala Val Tyr Tyr Cys Gln Gln Tyr Ser Asp Trp Pro Pro 
                85                  90                  95      


Leu Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105             


<210> 731
<211> 11
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L1"

<400> 731
Arg Ala Ser Gln Ser Val Ser Ser Ser Leu Ala 
1               5                   10      


<210> 732
<211> 33
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L1"

<400> 732
agggccagtc agagtgttag cagcagcttg gcc                                    33


<210> 733
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L2"

<400> 733
Gly Ala Ser Thr Arg Ala Thr 
1               5           


<210> 734
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L2"

<400> 734
ggtgcatcca ccagggccac t                                                 21


<210> 735
<211> 10
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L3"

<400> 735
Gln Gln Tyr Ser Asp Trp Pro Pro Leu Thr 
1               5                   10  


<210> 736
<211> 30
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L3"

<400> 736
cagcagtata gtgactggcc tccgctcact                                        30


<210> 737
<211> 375
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region"

<400> 737
gaggtgcagc tgttggagtc tgggggaggc ttggtcaagc ctggagggtc cctgagactc       60

tcctgtggag cctctggatt caagttcagt gactactaca tgagttggat ccgccaggct      120

ccagggaagg ggctagagtg ggtttcacac attagtagta gtaatagtta cataaactac      180

gcagactctg tgaagggccg attcaccatc tccagggaca acgccaggaa ctcactgtct      240

ctgcaaatga acagcctgag agccgaggac acggccgtgt attactgtgc gagattcccc      300

ctttactgta gtcgttcctc ctgctcccat tacgttgact actggggcca gggaaccctg      360

gtcaccgtct cctca                                                       375


<210> 738
<211> 125
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region"

<400> 738
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Gly Ala Ser Gly Phe Lys Phe Ser Asp Tyr 
            20                  25                  30          


Tyr Met Ser Trp Ile Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser His Ile Ser Ser Ser Asn Ser Tyr Ile Asn Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Arg Asn Ser Leu Ser 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Phe Pro Leu Tyr Cys Ser Arg Ser Ser Cys Ser His Tyr Val 
            100                 105                 110         


Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125 


<210> 739
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H1"

<400> 739
Phe Lys Phe Ser Asp Tyr Tyr Met Ser 
1               5                   


<210> 740
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H1"

<400> 740
ttcaagttca gtgactacta catgagt                                           27


<210> 741
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H2"

<400> 741
His Ile Ser Ser Ser Asn Ser Tyr Ile Asn Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210> 742
<211> 51
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H2"

<400> 742
cacattagta gtagtaatag ttacataaac tacgcagact ctgtgaaggg c                51


<210> 743
<211> 18
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H3"

<400> 743
Ala Arg Phe Pro Leu Tyr Cys Ser Arg Ser Ser Cys Ser His Tyr Val 
1               5                   10                  15      


Asp Tyr 
        


<210> 744
<211> 54
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H3"

<400> 744
gcgagattcc ccctttactg tagtcgttcc tcctgctccc attacgttga ctac             54


<210> 745
<211> 330
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region"

<400> 745
cagtctgtcc tgactcagcc tccctcagtg tctggggccc cagggcagag ggtcaccatc       60

tcctgcactg ggagcggctc caacatcggg gcaggttatg atgtacactg gtaccagcag      120

cttccaggaa cagcccccaa actcctcatc tatgataaca acaatcggcc ctcaggggtc      180

cctgaccgat tctctggctc caagtctggc acctcagcct ccctggccat cactgggctc      240

caggttgagg atgaggctga ttattactgc cagtcctatg acaggagcct gagtgtggta      300

ttcggcggag ggaccaaggt caccgtccta                                       330


<210> 746
<211> 110
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region"

<400> 746
Gln Ser Val Leu Thr Gln Pro Pro Ser Val Ser Gly Ala Pro Gly Gln 
1               5                   10                  15      


Arg Val Thr Ile Ser Cys Thr Gly Ser Gly Ser Asn Ile Gly Ala Gly 
            20                  25                  30          


Tyr Asp Val His Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu 
        35                  40                  45              


Leu Ile Tyr Asp Asn Asn Asn Arg Pro Ser Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Thr Gly Leu 
65                  70                  75                  80  


Gln Val Glu Asp Glu Ala Asp Tyr Tyr Cys Gln Ser Tyr Asp Arg Ser 
                85                  90                  95      


Leu Ser Val Val Phe Gly Gly Gly Thr Lys Val Thr Val Leu 
            100                 105                 110 


<210> 747
<211> 14
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L1"

<400> 747
Thr Gly Ser Gly Ser Asn Ile Gly Ala Gly Tyr Asp Val His 
1               5                   10                  


<210> 748
<211> 42
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L1"

<400> 748
actgggagcg gctccaacat cggggcaggt tatgatgtac ac                          42


<210> 749
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L2"

<400> 749
Asp Asn Asn Asn Arg Pro Ser 
1               5           


<210> 750
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L2"

<400> 750
gataacaaca atcggccctc a                                                 21


<210> 751
<211> 10
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L3"

<400> 751
Gln Ser Tyr Asp Arg Ser Leu Ser Val Val 
1               5                   10  


<210> 752
<211> 30
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L3"

<400> 752
cagtcctatg acaggagcct gagtgtggta                                        30


<210> 753
<211> 357
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region"

<400> 753
caggtgcagc tggtgcaatc tggaccagag gtgaaaaagc ccggggagtc tctgaagatc       60

tcctgtaagg gttctggata tacgtttact acctactgga tcggctgggt gcgccagagg      120

cccgggaagg gcctggagtg gatgggaatc atccatcccg gtgactctga taccagatac      180

agtccgtcct tacaaggcca ggtcaccatc tcagtcgaca agtccatcaa taccgcctac      240

ctgcagtgga ggagtttgaa ggcctcggac accggcatgt attattgtgc gagattcgaa      300

tacggtgact tcgggaatga cttctggggc cagggaaccc tggtcactgt ctcctca         357


<210> 754
<211> 119
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region"

<400> 754
Gln Val Gln Leu Val Gln Ser Gly Pro Glu Val Lys Lys Pro Gly Glu 
1               5                   10                  15      


Ser Leu Lys Ile Ser Cys Lys Gly Ser Gly Tyr Thr Phe Thr Thr Tyr 
            20                  25                  30          


Trp Ile Gly Trp Val Arg Gln Arg Pro Gly Lys Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Ile Ile His Pro Gly Asp Ser Asp Thr Arg Tyr Ser Pro Ser Leu 
    50                  55                  60                  


Gln Gly Gln Val Thr Ile Ser Val Asp Lys Ser Ile Asn Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Trp Arg Ser Leu Lys Ala Ser Asp Thr Gly Met Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Phe Glu Tyr Gly Asp Phe Gly Asn Asp Phe Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210> 755
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H1"

<400> 755
Tyr Thr Phe Thr Thr Tyr Trp Ile Gly 
1               5                   


<210> 756
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H1"

<400> 756
tatacgttta ctacctactg gatcggc                                           27


<210> 757
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H2"

<400> 757
Ile Ile His Pro Gly Asp Ser Asp Thr Arg Tyr Ser Pro Ser Leu Gln 
1               5                   10                  15      


Gly 
    


<210> 758
<211> 51
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H2"

<400> 758
atcatccatc ccggtgactc tgataccaga tacagtccgt ccttacaagg c                51


<210> 759
<211> 12
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H3"

<400> 759
Ala Arg Phe Glu Tyr Gly Asp Phe Gly Asn Asp Phe 
1               5                   10          


<210> 760
<211> 36
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H3"

<400> 760
gcgagattcg aatacggtga cttcgggaat gacttc                                 36


<210> 761
<211> 333
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region"

<400> 761
aattttatgc tgactcagcc ccactctgtg tcggagtctc cggggaagac ggtaaccatc       60

tcctgctccc gcagcagtgg cagcattgcc aacaactatg tgcagtggta ccagcagcgc      120

ccgggcagtt cccccaccac tgtgatctat gaggataacc aaagaccctc tggggtccct      180

gatcggttct ctggctccat cgacagctcc tccaactctg cctccctcac catctctgga      240

ctgaagactg aggacgaggc agactactac tgtcagtctt atgatagtag caatcatagg      300

gtgttcggcg gagggaccaa gctcaccgtc cta                                   333


<210> 762
<211> 111
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region"

<400> 762
Asn Phe Met Leu Thr Gln Pro His Ser Val Ser Glu Ser Pro Gly Lys 
1               5                   10                  15      


Thr Val Thr Ile Ser Cys Ser Arg Ser Ser Gly Ser Ile Ala Asn Asn 
            20                  25                  30          


Tyr Val Gln Trp Tyr Gln Gln Arg Pro Gly Ser Ser Pro Thr Thr Val 
        35                  40                  45              


Ile Tyr Glu Asp Asn Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Ile Asp Ser Ser Ser Asn Ser Ala Ser Leu Thr Ile Ser Gly 
65                  70                  75                  80  


Leu Lys Thr Glu Asp Glu Ala Asp Tyr Tyr Cys Gln Ser Tyr Asp Ser 
                85                  90                  95      


Ser Asn His Arg Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 110     


<210> 763
<211> 13
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L1"

<400> 763
Ser Arg Ser Ser Gly Ser Ile Ala Asn Asn Tyr Val Gln 
1               5                   10              


<210> 764
<211> 39
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L1"

<400> 764
tcccgcagca gtggcagcat tgccaacaac tatgtgcag                              39


<210> 765
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L2"

<400> 765
Glu Asp Asn Gln Arg Pro Ser 
1               5           


<210> 766
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L2"

<400> 766
gaggataacc aaagaccctc t                                                 21


<210> 767
<211> 10
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L3"

<400> 767
Gln Ser Tyr Asp Ser Ser Asn His Arg Val 
1               5                   10  


<210> 768
<211> 30
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L3"

<400> 768
cagtcttatg atagtagcaa tcatagggtg                                        30


<210> 769
<211> 369
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region"

<400> 769
gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgactc       60

tcctgtgcag cctctggatt cacctttagg agatatgcca tgacctgggt ccgccaggct      120

ccagggaagg ggctggagtg ggtcgcagct attactgcta ctggtgatac cacatactac      180

ccagactccg taaagggccg gttcgccgtc tccagagaca attcccggaa cacgctttat      240

ctgcaaatgg acagtctgag agccgaggac acggccctat attactgtgc gaaaagttgg      300

gatgactacg gtgacctgga ctggtacttc gctctctggg gccgtggcac cctggtcacc      360

gtctcctca                                                              369


<210> 770
<211> 123
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region"

<400> 770
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Arg Arg Tyr 
            20                  25                  30          


Ala Met Thr Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Ala Ile Thr Ala Thr Gly Asp Thr Thr Tyr Tyr Pro Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Ala Val Ser Arg Asp Asn Ser Arg Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asp Ser Leu Arg Ala Glu Asp Thr Ala Leu Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Ser Trp Asp Asp Tyr Gly Asp Leu Asp Trp Tyr Phe Ala Leu 
            100                 105                 110         


Trp Gly Arg Gly Thr Leu Val Thr Val Ser Ser 
        115                 120             


<210> 771
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H1"

<400> 771
Phe Thr Phe Arg Arg Tyr Ala Met Thr 
1               5                   


<210> 772
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H1"

<400> 772
ttcaccttta ggagatatgc catgacc                                           27


<210> 773
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H2"

<400> 773
Ala Ile Thr Ala Thr Gly Asp Thr Thr Tyr Tyr Pro Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210> 774
<211> 51
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H2"

<400> 774
gctattactg ctactggtga taccacatac tacccagact ccgtaaaggg c                51


<210> 775
<211> 16
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H3"

<400> 775
Ala Lys Ser Trp Asp Asp Tyr Gly Asp Leu Asp Trp Tyr Phe Ala Leu 
1               5                   10                  15      


<210> 776
<211> 48
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H3"

<400> 776
gcgaaaagtt gggatgacta cggtgacctg gactggtact tcgctctc                    48


<210> 777
<211> 324
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region"

<400> 777
gatattgtga tgacccagtc tccagccatc ctgtctgtgt ctccagggga aagagccacc       60

ctctcctgca gggccagtca gagtgttagc agcagcttgg cctggtacca gcagaaacct      120

ggccaggctc ccaggctcct catctacggt gcatccacca gggccactgg tatcccaccc      180

cggttcagtg gcagtgggtc tgggacacaa ttcactctca ccatcagcag cctgcagtct      240

gaagattttg cagtgtatta ctgtcagcag tatagtgact ggcctccgct cactttcggc      300

ggggggacca aggtggagat caaa                                             324


<210> 778
<211> 108
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region"

<400> 778
Asp Ile Val Met Thr Gln Ser Pro Ala Ile Leu Ser Val Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Ser 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 
        35                  40                  45              


Tyr Gly Ala Ser Thr Arg Ala Thr Gly Ile Pro Pro Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Gln Phe Thr Leu Thr Ile Ser Ser Leu Gln Ser 
65                  70                  75                  80  


Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Ser Asp Trp Pro Pro 
                85                  90                  95      


Leu Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105             


<210> 779
<211> 11
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L1"

<400> 779
Arg Ala Ser Gln Ser Val Ser Ser Ser Leu Ala 
1               5                   10      


<210> 780
<211> 33
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L1"

<400> 780
agggccagtc agagtgttag cagcagcttg gcc                                    33


<210> 781
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L2"

<400> 781
Gly Ala Ser Thr Arg Ala Thr 
1               5           


<210> 782
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L2"

<400> 782
ggtgcatcca ccagggccac t                                                 21


<210> 783
<211> 10
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L3"

<400> 783
Gln Gln Tyr Ser Asp Trp Pro Pro Leu Thr 
1               5                   10  


<210> 784
<211> 30
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L3"

<400> 784
cagcagtata gtgactggcc tccgctcact                                        30


<210> 785
<211> 369
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region"

<400> 785
caggtccagc ttgtacagtc tgggggaggt ttggtacagc ctggggggtc cctgagactc       60

tcctgtgcag cctctagatt cacctttagc agctatgcca tgagctgggt ccgccaggct      120

ccagggaagg ggctggagtg ggtctcaact attagtggta gtggtattag cacgtactac      180

gcagactccg tgaagggccg gttcaccatc tccagagaca attccaagaa cacgctgtat      240

ctgcaaatga acagcctgag cgccgaggac acggccgtat attactgtgc gaaagaattg      300

agggagtatt actatgatag cagtggcttt gactactggg gccagggaac cctggtcacc      360

gtctcctca                                                              369


<210> 786
<211> 123
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region"

<400> 786
Gln Val Gln Leu Val Gln Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Arg Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Thr Ile Ser Gly Ser Gly Ile Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Ser Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Glu Leu Arg Glu Tyr Tyr Tyr Asp Ser Ser Gly Phe Asp Tyr 
            100                 105                 110         


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120             


<210> 787
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H1"

<400> 787
Phe Thr Phe Ser Ser Tyr Ala Met Ser 
1               5                   


<210> 788
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H1"

<400> 788
ttcaccttta gcagctatgc catgagc                                           27


<210> 789
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H2"

<400> 789
Thr Ile Ser Gly Ser Gly Ile Ser Thr Tyr Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210> 790
<211> 51
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H2"

<400> 790
actattagtg gtagtggtat tagcacgtac tacgcagact ccgtgaaggg c                51


<210> 791
<211> 16
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H3"

<400> 791
Ala Lys Glu Leu Arg Glu Tyr Tyr Tyr Asp Ser Ser Gly Phe Asp Tyr 
1               5                   10                  15      


<210> 792
<211> 48
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H3"

<400> 792
gcgaaagaat tgagggagta ttactatgat agcagtggct ttgactac                    48


<210> 793
<211> 330
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region"

<400> 793
cagcctgtgc tgactcagtc tcgctcagtg tccgggtctc ctgaacagtc agtcaccatc       60

tcctgcactg gaaccagcag tgatgttggt ggttataact atgtctcctg gtaccaacag      120

cacccaggca aagcccccaa actcatgatt tatgatgtca gtaagcggcc ctcaggggtc      180

cctgatcgct tctctggctc caagtctggc aacacggcct ccctgaccat ctctgggctc      240

caggctgagg atgagtctga ttattactgc tgctcatatg caggcaccta cacttatgtc      300

ttcggaactg ggaccaaggt caccgtccta                                       330


<210> 794
<211> 110
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region"

<400> 794
Gln Pro Val Leu Thr Gln Ser Arg Ser Val Ser Gly Ser Pro Glu Gln 
1               5                   10                  15      


Ser Val Thr Ile Ser Cys Thr Gly Thr Ser Ser Asp Val Gly Gly Tyr 
            20                  25                  30          


Asn Tyr Val Ser Trp Tyr Gln Gln His Pro Gly Lys Ala Pro Lys Leu 
        35                  40                  45              


Met Ile Tyr Asp Val Ser Lys Arg Pro Ser Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Asn Thr Ala Ser Leu Thr Ile Ser Gly Leu 
65                  70                  75                  80  


Gln Ala Glu Asp Glu Ser Asp Tyr Tyr Cys Cys Ser Tyr Ala Gly Thr 
                85                  90                  95      


Tyr Thr Tyr Val Phe Gly Thr Gly Thr Lys Val Thr Val Leu 
            100                 105                 110 


<210> 795
<211> 14
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L1"

<400> 795
Thr Gly Thr Ser Ser Asp Val Gly Gly Tyr Asn Tyr Val Ser 
1               5                   10                  


<210> 796
<211> 42
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L1"

<400> 796
actggaacca gcagtgatgt tggtggttat aactatgtct cc                          42


<210> 797
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L2"

<400> 797
Asp Val Ser Lys Arg Pro Ser 
1               5           


<210> 798
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L2"

<400> 798
gatgtcagta agcggccctc a                                                 21


<210> 799
<211> 10
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L3"

<400> 799
Cys Ser Tyr Ala Gly Thr Tyr Thr Tyr Val 
1               5                   10  


<210> 800
<211> 30
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L3"

<400> 800
tgctcatatg caggcaccta cacttatgtc                                        30


<210> 801
<211> 381
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region"

<400> 801
gaggtgcagc tgttggagtc tgggggaggc gtggtccagc ctgggaggtc cctgaaactc       60

tcctgtgcag cctctggatt cagcttcact accgatgtta tgcactggat acgccaggct      120

ccaggcaagg ggctggagtg ggtggcagtt atttcaactg atggagccaa ttcatactac      180

gcagagtccg tgaagggccg attcaccatc tccagagaca attccaagaa cacgctgttt      240

ctgcagatga gcagcctgag agctgaggac acggctgtgt attattgtgc gagccaggga      300

tatcattatg ttaatatggc tgatgtggga gtgccctcgt ttgaccactg gggccaggga      360

accctggtca ccgtctcctc a                                                381


<210> 802
<211> 127
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region"

<400> 802
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Ser Phe Thr Thr Asp 
            20                  25                  30          


Val Met His Trp Ile Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Val Ile Ser Thr Asp Gly Ala Asn Ser Tyr Tyr Ala Glu Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Phe 
65                  70                  75                  80  


Leu Gln Met Ser Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ser Gln Gly Tyr His Tyr Val Asn Met Ala Asp Val Gly Val Pro 
            100                 105                 110         


Ser Phe Asp His Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125         


<210> 803
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H1"

<400> 803
Phe Ser Phe Thr Thr Asp Val Met His 
1               5                   


<210> 804
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H1"

<400> 804
ttcagcttca ctaccgatgt tatgcac                                           27


<210> 805
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H2"

<400> 805
Val Ile Ser Thr Asp Gly Ala Asn Ser Tyr Tyr Ala Glu Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210> 806
<211> 51
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H2"

<400> 806
gttatttcaa ctgatggagc caattcatac tacgcagagt ccgtgaaggg c                51


<210> 807
<211> 20
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H3"

<400> 807
Ala Ser Gln Gly Tyr His Tyr Val Asn Met Ala Asp Val Gly Val Pro 
1               5                   10                  15      


Ser Phe Asp His 
            20  


<210> 808
<211> 60
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H3"

<400> 808
gcgagccagg gatatcatta tgttaatatg gctgatgtgg gagtgccctc gtttgaccac       60


<210> 809
<211> 321
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region"

<400> 809
gaaacgacac tcacgcagtc tccatcctcc ctgtctgcat ctgtcggaga cagagtcacc       60

atcacttgcc gggcacgtcg gagcattgac aactatttaa attggtatca gcacaaacca      120

gggacagccc ctaagctcct gatctatgct gtatccagtt tgcctagcgg ggtcccatcg      180

agattcagtg gcagtggatc tggggcagac ttcactctca ccatcagcag tctgcaacct      240

gaagatcttg caacttacta ctgtcaacag agttacatga cccctcccac ttttggccag      300

gggaccaagc tggagatcaa a                                                321


<210> 810
<211> 107
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region"

<400> 810
Glu Thr Thr Leu Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Arg Arg Ser Ile Asp Asn Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln His Lys Pro Gly Thr Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ala Val Ser Ser Leu Pro Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Ala Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Leu Ala Thr Tyr Tyr Cys Gln Gln Ser Tyr Met Thr Pro Pro 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210> 811
<211> 11
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L1"

<400> 811
Arg Ala Arg Arg Ser Ile Asp Asn Tyr Leu Asn 
1               5                   10      


<210> 812
<211> 33
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L1"

<400> 812
cgggcacgtc ggagcattga caactattta aat                                    33


<210> 813
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L2"

<400> 813
Ala Val Ser Ser Leu Pro Ser 
1               5           


<210> 814
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L2"

<400> 814
gctgtatcca gtttgcctag c                                                 21


<210> 815
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L3"

<400> 815
Gln Gln Ser Tyr Met Thr Pro Pro Thr 
1               5                   


<210> 816
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L3"

<400> 816
caacagagtt acatgacccc tcccact                                           27


<210> 817
<211> 372
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region"

<400> 817
gaggtgcagc tgttggagtc tggggctgag gtgaagaagc ctgggtcctc ggtgaaggtc       60

tcctgcaagg cttctggcgg caccttcagc agctatgcta taacctgggt gcgacaggcc      120

cctggacaag gacttgagtg gatgggaggg atcatcccta tccttggaac aacaacctac      180

gcacagaggt tccagggcag agtcacgatt accgcggaca aatccacgac aacagcctac      240

atggagctga gtcgcctgag atctgaggac acggccgtct attactgtgc gaaaacggtg      300

tcacaatatc ccaacaccta caactacggc atggacgtct ggggccaagg gaccacggtc      360

accgtctcct ca                                                          372


<210> 818
<211> 124
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region"

<400> 818
Glu Val Gln Leu Leu Glu Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Ile Thr Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Gly Ile Ile Pro Ile Leu Gly Thr Thr Thr Tyr Ala Gln Arg Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Ala Asp Lys Ser Thr Thr Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Arg Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Thr Val Ser Gln Tyr Pro Asn Thr Tyr Asn Tyr Gly Met Asp 
            100                 105                 110         


Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120                 


<210> 819
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H1"

<400> 819
Gly Thr Phe Ser Ser Tyr Ala Ile Thr 
1               5                   


<210> 820
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H1"

<400> 820
ggcaccttca gcagctatgc tataacc                                           27


<210> 821
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H2"

<400> 821
Gly Ile Ile Pro Ile Leu Gly Thr Thr Thr Tyr Ala Gln Arg Phe Gln 
1               5                   10                  15      


Gly 
    


<210> 822
<211> 51
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H2"

<400> 822
gggatcatcc ctatccttgg aacaacaacc tacgcacaga ggttccaggg c                51


<210> 823
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H3"

<400> 823
Ala Lys Thr Val Ser Gln Tyr Pro Asn Thr Tyr Asn Tyr Gly Met Asp 
1               5                   10                  15      


Val 
    


<210> 824
<211> 51
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H3"

<400> 824
gcgaaaacgg tgtcacaata tcccaacacc tacaactacg gcatggacgt c                51


<210> 825
<211> 321
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region"

<400> 825
gaaattgtga tgacacagtc tccctcctcc ctgtctgcat ctgtaggaga cagagtcacc       60

atcacttgcc gggcaagtca gagcgttagc atctatttaa actggtatca gcagaaacca      120

gggaaaaccc ctgagctcct gatctatggt gcatcccgtt tgcaaagtgg ggtcccatca      180

aggttcagtg gcagtggatc tgggacagat ttcactctca ccatcagcag tctgcaacct      240

gaagattttg caacttacta ctgtctacag acgtactcta cccccctcac cttcggccaa      300

gggaccaagg tggaaatcaa a                                                321


<210> 826
<211> 107
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region"

<400> 826
Glu Ile Val Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Val Ser Ile Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Thr Pro Glu Leu Leu Ile 
        35                  40                  45              


Tyr Gly Ala Ser Arg Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Leu Gln Thr Tyr Ser Thr Pro Leu 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210> 827
<211> 11
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L1"

<400> 827
Arg Ala Ser Gln Ser Val Ser Ile Tyr Leu Asn 
1               5                   10      


<210> 828
<211> 33
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L1"

<400> 828
cgggcaagtc agagcgttag catctattta aac                                    33


<210> 829
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L2"

<400> 829
Gly Ala Ser Arg Leu Gln Ser 
1               5           


<210> 830
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L2"

<400> 830
ggtgcatccc gtttgcaaag t                                                 21


<210> 831
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L3"

<400> 831
Leu Gln Thr Tyr Ser Thr Pro Leu Thr 
1               5                   


<210> 832
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L3"

<400> 832
ctacagacgt actctacccc cctcacc                                           27


<210> 833
<211> 390
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region"

<400> 833
caggtgcagc tggtggagtc tggggctgag gtgaagaagc ctgggtcctc ggtgaaggtc       60

tcctgcaagg cttctggagg caccttcggc agggattcta tcagctgggt gcgacaggcc      120

cctgggcagg gccttgagtg gatgggaggg atcaacccta tctttcatac atcacactac      180

gcacagaaat tccagggcag agtcacaatt accgcggacg agtccacgag cacagcctac      240

atggaactgg gcaacctgag atctgaggac acggccatgt attactgtgc gagagttccc      300

cccccccggg gtcattgtga gagtaccagc tgtttatggg ggacctattt tgccttctgg      360

ggccagggaa ccctggtcac cgtctcctca                                       390


<210> 834
<211> 130
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region"

<400> 834
Gln Val Gln Leu Val Glu Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Gly Arg Asp 
            20                  25                  30          


Ser Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Gly Ile Asn Pro Ile Phe His Thr Ser His Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Gly Asn Leu Arg Ser Glu Asp Thr Ala Met Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Val Pro Pro Pro Arg Gly His Cys Glu Ser Thr Ser Cys Leu 
            100                 105                 110         


Trp Gly Thr Tyr Phe Ala Phe Trp Gly Gln Gly Thr Leu Val Thr Val 
        115                 120                 125             


Ser Ser 
    130 


<210> 835
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H1"

<400> 835
Gly Thr Phe Gly Arg Asp Ser Ile Ser 
1               5                   


<210> 836
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H1"

<400> 836
ggcaccttcg gcagggattc tatcagc                                           27


<210> 837
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H2"

<400> 837
Gly Ile Asn Pro Ile Phe His Thr Ser His Tyr Ala Gln Lys Phe Gln 
1               5                   10                  15      


Gly 
    


<210> 838
<211> 51
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H2"

<400> 838
gggatcaacc ctatctttca tacatcacac tacgcacaga aattccaggg c                51


<210> 839
<211> 23
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H3"

<400> 839
Ala Arg Val Pro Pro Pro Arg Gly His Cys Glu Ser Thr Ser Cys Leu 
1               5                   10                  15      


Trp Gly Thr Tyr Phe Ala Phe 
            20              


<210> 840
<211> 69
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H3"

<400> 840
gcgagagttc cccccccccg gggtcattgt gagagtacca gctgtttatg ggggacctat       60

tttgccttc                                                               69


<210> 841
<211> 327
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region"

<400> 841
gaaacgacac tcacgcagtc tccagccacc ctgtctttgt ctccagggga aagagccacc       60

ctctcctgca gggccagtca gagggttcgc agctacttag cctggtacca gcagaaacct      120

ggccaggctc ccaggctcct catctatgat gcatccatca gggctactgg catcccagcc      180

aggttcagtg gcagtgggtc tggggcagac ttcactctca ccatcagcag cctcgagcct      240

gaagattttg cagtttatta ctgtcagctg cgtgactact ggcctcccac gtggacgttc      300

ggccaaggga ccaaggtgga aatcaaa                                          327


<210> 842
<211> 109
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region"

<400> 842
Glu Thr Thr Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Arg Val Arg Ser Tyr 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 
        35                  40                  45              


Tyr Asp Ala Ser Ile Arg Ala Thr Gly Ile Pro Ala Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Ala Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Val Tyr Tyr Cys Gln Leu Arg Asp Tyr Trp Pro Pro 
                85                  90                  95      


Thr Trp Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105                 


<210> 843
<211> 11
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L1"

<400> 843
Arg Ala Ser Gln Arg Val Arg Ser Tyr Leu Ala 
1               5                   10      


<210> 844
<211> 33
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L1"

<400> 844
agggccagtc agagggttcg cagctactta gcc                                    33


<210> 845
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L2"

<400> 845
Asp Ala Ser Ile Arg Ala Thr 
1               5           


<210> 846
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L2"

<400> 846
gatgcatcca tcagggctac t                                                 21


<210> 847
<211> 11
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L3"

<400> 847
Gln Leu Arg Asp Tyr Trp Pro Pro Thr Trp Thr 
1               5                   10      


<210> 848
<211> 33
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L3"

<400> 848
cagctgcgtg actactggcc tcccacgtgg acg                                    33


<210> 849
<211> 366
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region"

<400> 849
gaggtgcagc tgttggagtc tgggggagac ctggtacagc cgggggggtc cctgagactc       60

tcctgtgcag cctctggatt ccccttcagc agccatagca tgaactgggt ccgccaggct      120

ccagggaagg gcctggagtg gatctcatac attagtggtg gtagtgatac cattcagtac      180

gcagactctg tgaagggccg atttaccatc tccagagaca atgtcaagaa ttcactgtat      240

ctgcaaatga acagcctgag agccgaggac acggctgtct attactgtgc gagagaccag      300

tatatttgga actatgtgga acctcttgac tactggggcc agggaaccct ggtcaccgtc      360

tcctca                                                                 366


<210> 850
<211> 122
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region"

<400> 850
Glu Val Gln Leu Leu Glu Ser Gly Gly Asp Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Pro Phe Ser Ser His 
            20                  25                  30          


Ser Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Ser Tyr Ile Ser Gly Gly Ser Asp Thr Ile Gln Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Val Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Gln Tyr Ile Trp Asn Tyr Val Glu Pro Leu Asp Tyr Trp 
            100                 105                 110         


Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120         


<210> 851
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H1"

<400> 851
Phe Pro Phe Ser Ser His Ser Met Asn 
1               5                   


<210> 852
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H1"

<400> 852
ttccccttca gcagccatag catgaac                                           27


<210> 853
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H2"

<400> 853
Tyr Ile Ser Gly Gly Ser Asp Thr Ile Gln Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210> 854
<211> 51
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H2"

<400> 854
tacattagtg gtggtagtga taccattcag tacgcagact ctgtgaaggg c                51


<210> 855
<211> 15
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H3"

<400> 855
Ala Arg Asp Gln Tyr Ile Trp Asn Tyr Val Glu Pro Leu Asp Tyr 
1               5                   10                  15  


<210> 856
<211> 45
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H3"

<400> 856
gcgagagacc agtatatttg gaactatgtg gaacctcttg actac                       45


<210> 857
<211> 321
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region"

<400> 857
gacatccaga tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga cagagtcacc       60

atcacttgcc gggcaagtca ggacattagc tattatttag gctggtatca gcagaaagca      120

gggaaagccc cgaagctcct gatttatgct gtatccaatt tgcaaactgg ggtcccatca      180

aggttcagcg gcagtggatc tggcacagat ttcactctca ccatcagcag cctgcagcct      240

gaagatttcg caacttatta ttgtctacaa gatcacactt gcccttggac gttcggccaa      300

gggaccaagg tggaaatcaa a                                                321


<210> 858
<211> 107
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region"

<400> 858
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Ile Ser Tyr Tyr 
            20                  25                  30          


Leu Gly Trp Tyr Gln Gln Lys Ala Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ala Val Ser Asn Leu Gln Thr Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Leu Gln Asp His Thr Cys Pro Trp 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210> 859
<211> 11
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L1"

<400> 859
Arg Ala Ser Gln Asp Ile Ser Tyr Tyr Leu Gly 
1               5                   10      


<210> 860
<211> 33
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L1"

<400> 860
cgggcaagtc aggacattag ctattattta ggc                                    33


<210> 861
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L2"

<400> 861
Ala Val Ser Asn Leu Gln Thr 
1               5           


<210> 862
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L2"

<400> 862
gctgtatcca atttgcaaac t                                                 21


<210> 863
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L3"

<400> 863
Leu Gln Asp His Thr Cys Pro Trp Thr 
1               5                   


<210> 864
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L3"

<400> 864
ctacaagatc acacttgccc ttggacg                                           27


<210> 865
<211> 366
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region"

<400> 865
gaggtgcagc tggtggagtc tggggctgag gtgaagaagc ctgggtcctc ggtgaaagtc       60

tcctgcaagg tttctggagg caccttcagc acttatggta tcagctggat acaacaggcc      120

cctggacaag ggcttgagtg ggtgggaggg atcatcccta tgtttgggac agcaaactac      180

gcacagaggt ttcagggcag agtcaccctt accgcggacg aaggcacgaa cacagcttac      240

atggagctga acaacctgag atctgaggac acggccatgt attactgtgc gagagatcga      300

ggtaataacg gccgctacta cgctatggac gtctggggcc aggggaccac ggtcaccgtc      360

tcctca                                                                 366


<210> 866
<211> 122
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region"

<400> 866
Glu Val Gln Leu Val Glu Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Val Ser Gly Gly Thr Phe Ser Thr Tyr 
            20                  25                  30          


Gly Ile Ser Trp Ile Gln Gln Ala Pro Gly Gln Gly Leu Glu Trp Val 
        35                  40                  45              


Gly Gly Ile Ile Pro Met Phe Gly Thr Ala Asn Tyr Ala Gln Arg Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Leu Thr Ala Asp Glu Gly Thr Asn Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Asn Asn Leu Arg Ser Glu Asp Thr Ala Met Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Arg Gly Asn Asn Gly Arg Tyr Tyr Ala Met Asp Val Trp 
            100                 105                 110         


Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120         


<210> 867
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H1"

<400> 867
Gly Thr Phe Ser Thr Tyr Gly Ile Ser 
1               5                   


<210> 868
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H1"

<400> 868
ggcaccttca gcacttatgg tatcagc                                           27


<210> 869
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H2"

<400> 869
Gly Ile Ile Pro Met Phe Gly Thr Ala Asn Tyr Ala Gln Arg Phe Gln 
1               5                   10                  15      


Gly 
    


<210> 870
<211> 51
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H2"

<400> 870
gggatcatcc ctatgtttgg gacagcaaac tacgcacaga ggtttcaggg c                51


<210> 871
<211> 15
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H3"

<400> 871
Ala Arg Asp Arg Gly Asn Asn Gly Arg Tyr Tyr Ala Met Asp Val 
1               5                   10                  15  


<210> 872
<211> 45
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H3"

<400> 872
gcgagagatc gaggtaataa cggccgctac tacgctatgg acgtc                       45


<210> 873
<211> 321
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region"

<400> 873
gatattgtgc tgacccagac tccagccacc ctgtctttgt ctccagggga aagagccacc       60

ctctcctgca gggccagtca gagtgtcacc acctacttag cgtggtacca acagaaacct      120

ggccaggctc ccaggctcct catctatgat acatccaaca gggccactgg catcccagcc      180

aggttcagtg gcagtgggtc tgggacagac ttcactctca ccatcagcag cctagagcct      240

gaagattttg cagtttatta ctgtcagcag cgtaacaact ggccgccgac cttcggccaa      300

gggacacgac tggagattaa a                                                321


<210> 874
<211> 107
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region"

<400> 874
Asp Ile Val Leu Thr Gln Thr Pro Ala Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Thr Thr Tyr 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 
        35                  40                  45              


Tyr Asp Thr Ser Asn Arg Ala Thr Gly Ile Pro Ala Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Arg Asn Asn Trp Pro Pro 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Arg Leu Glu Ile Lys 
            100                 105         


<210> 875
<211> 11
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L1"

<400> 875
Arg Ala Ser Gln Ser Val Thr Thr Tyr Leu Ala 
1               5                   10      


<210> 876
<211> 33
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L1"

<400> 876
agggccagtc agagtgtcac cacctactta gcg                                    33


<210> 877
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L2"

<400> 877
Asp Thr Ser Asn Arg Ala Thr 
1               5           


<210> 878
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L2"

<400> 878
gatacatcca acagggccac t                                                 21


<210> 879
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L3"

<400> 879
Gln Gln Arg Asn Asn Trp Pro Pro Thr 
1               5                   


<210> 880
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L3"

<400> 880
cagcagcgta acaactggcc gccgacc                                           27


<210> 881
<211> 357
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region"

<400> 881
gaggtgcagc tgttggagtc tgggggaggc ctggtcaagc ctggggggtc cctgagactc       60

tcctgtgcag cctcgggatt caccatcagt ggttataaca tgttctgggt ccgccagcct      120

ccggggaagg ggctggagtg ggtctcatcc attactgctg gtagtagtta tttaaactat      180

gcagactcag tgaagggccg tttcatcgtc tccagagaca acgccaagaa ttcactgtat      240

ctgcaaatga acagcctgag agccgaggac acggctgttt atttctgtgc gagagcacct      300

cttttacccg ctatgatgga cctctggggc caagggacca cggtcaccgt ctcctca         357


<210> 882
<211> 119
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region"

<400> 882
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Ile Ser Gly Tyr 
            20                  25                  30          


Asn Met Phe Trp Val Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ser Ile Thr Ala Gly Ser Ser Tyr Leu Asn Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Ile Val Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Phe Cys 
                85                  90                  95      


Ala Arg Ala Pro Leu Leu Pro Ala Met Met Asp Leu Trp Gly Gln Gly 
            100                 105                 110         


Thr Thr Val Thr Val Ser Ser 
        115                 


<210> 883
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H1"

<400> 883
Phe Thr Ile Ser Gly Tyr Asn Met Phe 
1               5                   


<210> 884
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H1"

<400> 884
ttcaccatca gtggttataa catgttc                                           27


<210> 885
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H2"

<400> 885
Ser Ile Thr Ala Gly Ser Ser Tyr Leu Asn Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210> 886
<211> 51
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H2"

<400> 886
tccattactg ctggtagtag ttatttaaac tatgcagact cagtgaaggg c                51


<210> 887
<211> 12
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H3"

<400> 887
Ala Arg Ala Pro Leu Leu Pro Ala Met Met Asp Leu 
1               5                   10          


<210> 888
<211> 36
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H3"

<400> 888
gcgagagcac ctcttttacc cgctatgatg gacctc                                 36


<210> 889
<211> 333
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region"

<400> 889
cagtctgtct tgacgcagcc gccctcagtg tctggggccc cagggcagag ggtcaccatc       60

tcctgcactg ggagcagctc caacatcggg gcaggttatg atgtacactg gtaccagcaa      120

cttccaggaa cagcccccaa actcctcatc tatactaaca acaatcggcc ctcaggggtc      180

cctgaccgat tctctggctc caagtctggc acctcagcct ccctggccat cactgggctc      240

caggctgagg atgaggctga ctattactgc cagtcctatg acagaagcct gaatggttat      300

gtcttcggaa ctgggaccaa gctcaccgtc cta                                   333


<210> 890
<211> 111
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region"

<400> 890
Gln Ser Val Leu Thr Gln Pro Pro Ser Val Ser Gly Ala Pro Gly Gln 
1               5                   10                  15      


Arg Val Thr Ile Ser Cys Thr Gly Ser Ser Ser Asn Ile Gly Ala Gly 
            20                  25                  30          


Tyr Asp Val His Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu 
        35                  40                  45              


Leu Ile Tyr Thr Asn Asn Asn Arg Pro Ser Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Thr Gly Leu 
65                  70                  75                  80  


Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Gln Ser Tyr Asp Arg Ser 
                85                  90                  95      


Leu Asn Gly Tyr Val Phe Gly Thr Gly Thr Lys Leu Thr Val Leu 
            100                 105                 110     


<210> 891
<211> 14
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L1"

<400> 891
Thr Gly Ser Ser Ser Asn Ile Gly Ala Gly Tyr Asp Val His 
1               5                   10                  


<210> 892
<211> 42
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L1"

<400> 892
actgggagca gctccaacat cggggcaggt tatgatgtac ac                          42


<210> 893
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L2"

<400> 893
Thr Asn Asn Asn Arg Pro Ser 
1               5           


<210> 894
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L2"

<400> 894
actaacaaca atcggccctc a                                                 21


<210> 895
<211> 11
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L3"

<400> 895
Gln Ser Tyr Asp Arg Ser Leu Asn Gly Tyr Val 
1               5                   10      


<210> 896
<211> 33
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L3"

<400> 896
cagtcctatg acagaagcct gaatggttat gtc                                    33


<210> 897
<211> 372
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region"

<400> 897
gaggtgcagc tggtggagac tgggggaggc ctggtcaagc ctggggggtc cctgagactc       60

tcctgtgcag gctctggatt caccttcagt agctataccc tgaactgggt ccgccaggct      120

ccagggaagg ggctggagtg ggtctcatct attagtagta gtagtactta catatactac      180

gcagactcag tgaagggccg attcaccatc tccagagaca acgccaagaa ctcactgcat      240

ctgcaaatga acagcctgag agccgaggac acggctgtgt attattgtgc gagagctgac      300

tatgatagaa gtgtttatca cctcaattgg ctcgacccct ggggccaggg aaccctggtc      360

accgtctcct ca                                                          372


<210> 898
<211> 124
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region"

<400> 898
Glu Val Gln Leu Val Glu Thr Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Gly Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Thr Leu Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ser Ile Ser Ser Ser Ser Thr Tyr Ile Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu His 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ala Asp Tyr Asp Arg Ser Val Tyr His Leu Asn Trp Leu Asp 
            100                 105                 110         


Pro Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 


<210> 899
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H1"

<400> 899
Phe Thr Phe Ser Ser Tyr Thr Leu Asn 
1               5                   


<210> 900
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H1"

<400> 900
ttcaccttca gtagctatac cctgaac                                           27


<210> 901
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H2"

<400> 901
Ser Ile Ser Ser Ser Ser Thr Tyr Ile Tyr Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210> 902
<211> 51
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H2"

<400> 902
tctattagta gtagtagtac ttacatatac tacgcagact cagtgaaggg c                51


<210> 903
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H3"

<400> 903
Ala Arg Ala Asp Tyr Asp Arg Ser Val Tyr His Leu Asn Trp Leu Asp 
1               5                   10                  15      


Pro 
    


<210> 904
<211> 51
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H3"

<400> 904
gcgagagctg actatgatag aagtgtttat cacctcaatt ggctcgaccc c                51


<210> 905
<211> 336
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region"

<400> 905
cagcctgtgc tgactcagcc gccctcagtg tctggggccc cagggcagag ggtcaccatc       60

tcctgcactg ggagcagctc caacatcggg gcaggttatg atgtacactg gtaccagcaa      120

cttccaggag cagcccccaa actcctcatc tatggtaaca ccaatcggcc ctcaggggtc      180

cctgaccgat tttctggctc caagtctggc acctcagcct ccctggccat cactgggctc      240

caggctgacg atgaggctga ttattactgc cagtcctatg acagcagcct gagtggcact      300

tgggtgttcg gcggagggac caagctcacc gtccta                                336


<210> 906
<211> 112
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region"

<400> 906
Gln Pro Val Leu Thr Gln Pro Pro Ser Val Ser Gly Ala Pro Gly Gln 
1               5                   10                  15      


Arg Val Thr Ile Ser Cys Thr Gly Ser Ser Ser Asn Ile Gly Ala Gly 
            20                  25                  30          


Tyr Asp Val His Trp Tyr Gln Gln Leu Pro Gly Ala Ala Pro Lys Leu 
        35                  40                  45              


Leu Ile Tyr Gly Asn Thr Asn Arg Pro Ser Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Thr Gly Leu 
65                  70                  75                  80  


Gln Ala Asp Asp Glu Ala Asp Tyr Tyr Cys Gln Ser Tyr Asp Ser Ser 
                85                  90                  95      


Leu Ser Gly Thr Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 110         


<210> 907
<211> 14
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L1"

<400> 907
Thr Gly Ser Ser Ser Asn Ile Gly Ala Gly Tyr Asp Val His 
1               5                   10                  


<210> 908
<211> 42
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L1"

<400> 908
actgggagca gctccaacat cggggcaggt tatgatgtac ac                          42


<210> 909
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L2"

<400> 909
Gly Asn Thr Asn Arg Pro Ser 
1               5           


<210> 910
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L2"

<400> 910
ggtaacacca atcggccctc a                                                 21


<210> 911
<211> 12
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L3"

<400> 911
Gln Ser Tyr Asp Ser Ser Leu Ser Gly Thr Trp Val 
1               5                   10          


<210> 912
<211> 36
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L3"

<400> 912
cagtcctatg acagcagcct gagtggcact tgggtg                                 36


<210> 913
<211> 363
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region"

<400> 913
caggtgcagc tggtgcagtc tgggggaggc ttggtcaagc ctggagggtc cctgagactc       60

tcctgtgcag cctctggatt caccttcagt gaccactaca tgacctggat ccgccaggct      120

ccagggaagg ggctggagtg ggtttcatac attagcagta ctagtagttt cacaaactac      180

gcagactctg tgaagggccg attcaccatc tccagagaca acgccaagaa gtcactttat      240

ctgcaaatga acagcctgag agccgaggac acggctgtgt attactgtgc gagagaccgc      300

aattggggat atgcctatgg ttctgactac tggggccagg gaaccctggt caccgtctcc      360

tca                                                                    363


<210> 914
<211> 121
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region"

<400> 914
Gln Val Gln Leu Val Gln Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp His 
            20                  25                  30          


Tyr Met Thr Trp Ile Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Tyr Ile Ser Ser Thr Ser Ser Phe Thr Asn Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Lys Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Arg Asn Trp Gly Tyr Ala Tyr Gly Ser Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120     


<210> 915
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H1"

<400> 915
Phe Thr Phe Ser Asp His Tyr Met Thr 
1               5                   


<210> 916
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H1"

<400> 916
ttcaccttca gtgaccacta catgacc                                           27


<210> 917
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H2"

<400> 917
Tyr Ile Ser Ser Thr Ser Ser Phe Thr Asn Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210> 918
<211> 51
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H2"

<400> 918
tacattagca gtactagtag tttcacaaac tacgcagact ctgtgaaggg c                51


<210> 919
<211> 14
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H3"

<400> 919
Ala Arg Asp Arg Asn Trp Gly Tyr Ala Tyr Gly Ser Asp Tyr 
1               5                   10                  


<210> 920
<211> 42
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H3"

<400> 920
gcgagagacc gcaattgggg atatgcctat ggttctgact ac                          42


<210> 921
<211> 321
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region"

<400> 921
gacatccggt tgacccagtc tccagacacc ctgtctttgt ctccagggga aagagccacc       60

ctctcctgca gggccagtca gagtgttagc agcacctact tagcctggta ccagcagaaa      120

cctggccagg ctcccaggct cctcatttat ggtgcattcg gcagggccac tggcatccca      180

gacaggttca gtggcagtgg gtctgggaca gacttcactc tcaccatcag cagactggag      240

cctgaagatt ttgcagtgta ttactgtcag ctgtatggta actcacggac gttcggccaa      300

gggaccaagc tggagatcaa a                                                321


<210> 922
<211> 107
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region"

<400> 922
Asp Ile Arg Leu Thr Gln Ser Pro Asp Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Thr 
            20                  25                  30          


Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu 
        35                  40                  45              


Ile Tyr Gly Ala Phe Gly Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu 
65                  70                  75                  80  


Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Leu Tyr Gly Asn Ser Arg 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210> 923
<211> 12
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L1"

<400> 923
Arg Ala Ser Gln Ser Val Ser Ser Thr Tyr Leu Ala 
1               5                   10          


<210> 924
<211> 36
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L1"

<400> 924
agggccagtc agagtgttag cagcacctac ttagcc                                 36


<210> 925
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L2"

<400> 925
Gly Ala Phe Gly Arg Ala Thr 
1               5           


<210> 926
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L2"

<400> 926
ggtgcattcg gcagggccac t                                                 21


<210> 927
<211> 8
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L3"

<400> 927
Gln Leu Tyr Gly Asn Ser Arg Thr 
1               5               


<210> 928
<211> 24
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L3"

<400> 928
cagctgtatg gtaactcacg gacg                                              24


<210> 929
<211> 411
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region"

<400> 929
gaggtgcagc tggtggagtc tgggggaggc ttggtacagc ctggggggtc cctgagaatc       60

tcctgtgcag cctctggatt ctccattagt agtcatgccg tgagctgggt ccgccaggct      120

ccagggaagg ggctggagtg ggtctcagtt attagtggga gtggtggtga cacacactcc      180

gtagttcaag gtcgtggtag tggcacatat tacgcagact ccgtgaaggg ccggttcacc      240

atctccagag acaatgtcag gaacacagtg tatctgcaaa tgaatagcct gagggtcgag      300

gacacggccg tatattattg tgcgaaagac gaccccacgc ttttttggag tggttcgggg      360

tactacggaa tggacgtctg gggccaaggg accacggtca ccgtctcctc a               411


<210> 930
<211> 137
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region"

<400> 930
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Ile Ser Cys Ala Ala Ser Gly Phe Ser Ile Ser Ser His 
            20                  25                  30          


Ala Val Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Val Ile Ser Gly Ser Gly Gly Asp Thr His Ser Val Val Gln Gly 
    50                  55                  60                  


Arg Gly Ser Gly Thr Tyr Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr 
65                  70                  75                  80  


Ile Ser Arg Asp Asn Val Arg Asn Thr Val Tyr Leu Gln Met Asn Ser 
                85                  90                  95      


Leu Arg Val Glu Asp Thr Ala Val Tyr Tyr Cys Ala Lys Asp Asp Pro 
            100                 105                 110         


Thr Leu Phe Trp Ser Gly Ser Gly Tyr Tyr Gly Met Asp Val Trp Gly 
        115                 120                 125             


Gln Gly Thr Thr Val Thr Val Ser Ser 
    130                 135         


<210> 931
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H1"

<400> 931
Phe Ser Ile Ser Ser His Ala Val Ser 
1               5                   


<210> 932
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H1"

<400> 932
ttctccatta gtagtcatgc cgtgagc                                           27


<210> 933
<211> 28
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H2"

<400> 933
Val Ile Ser Gly Ser Gly Gly Asp Thr His Ser Val Val Gln Gly Arg 
1               5                   10                  15      


Gly Ser Gly Thr Tyr Tyr Ala Asp Ser Val Lys Gly 
            20                  25              


<210> 934
<211> 84
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H2"

<400> 934
gttattagtg ggagtggtgg tgacacacac tccgtagttc aaggtcgtgg tagtggcaca       60

tattacgcag actccgtgaa gggc                                              84


<210> 935
<211> 19
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H3"

<400> 935
Ala Lys Asp Asp Pro Thr Leu Phe Trp Ser Gly Ser Gly Tyr Tyr Gly 
1               5                   10                  15      


Met Asp Val 
            


<210> 936
<211> 57
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H3"

<400> 936
gcgaaagacg accccacgct tttttggagt ggttcggggt actacggaat ggacgtc          57


<210> 937
<211> 321
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region"

<400> 937
gacatccggg tgacccagtc tccatcctcc ctgtctgcat ctgttggaga cagagtcacc       60

atcacttgcc aggcgagtca gggcattagc gactctttaa attggtatca gcagaaacca      120

gggaaagccc ctaagctcct gatctacggt gcatccaaat tggaaccagg ggtctcatca      180

aggttcagcg gacgaggatc tgggagagat tttactttca ccatcagcag cctgcagcct      240

gaagatatcg gaacatatta ctgtcaacag tatgataatc tccctctgac tttcggccct      300

gggaccaagc tggagatcaa a                                                321


<210> 938
<211> 107
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region"

<400> 938
Asp Ile Arg Val Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Gln Ala Ser Gln Gly Ile Ser Asp Ser 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Gly Ala Ser Lys Leu Glu Pro Gly Val Ser Ser Arg Phe Ser Gly 
    50                  55                  60                  


Arg Gly Ser Gly Arg Asp Phe Thr Phe Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Ile Gly Thr Tyr Tyr Cys Gln Gln Tyr Asp Asn Leu Pro Leu 
                85                  90                  95      


Thr Phe Gly Pro Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210> 939
<211> 11
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L1"

<400> 939
Gln Ala Ser Gln Gly Ile Ser Asp Ser Leu Asn 
1               5                   10      


<210> 940
<211> 33
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L1"

<400> 940
caggcgagtc agggcattag cgactcttta aat                                    33


<210> 941
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L2"

<400> 941
Gly Ala Ser Lys Leu Glu Pro 
1               5           


<210> 942
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L2"

<400> 942
ggtgcatcca aattggaacc a                                                 21


<210> 943
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L3"

<400> 943
Gln Gln Tyr Asp Asn Leu Pro Leu Thr 
1               5                   


<210> 944
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L3"

<400> 944
caacagtatg ataatctccc tctgact                                           27


<210> 945
<211> 375
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region"

<400> 945
gaggtgcagc tggtggagac ggggggcggc ttgatacagc cgggggggtc cctgagactc       60

tcctgcgtgg cctccggatt cagccttagg aactatgcct taggttggct ccgccaggcg      120

ccagggaagg ggctggagtg ggtctcaggt ggctattatg gtgatgtcta ttacacggac      180

tccgtgaagg gccggttcgc cgtctccagg gacaattccg gggacacagt atatctagaa      240

atggacaacc tgagagtcga agacacggcc gtgtattact gtgcgagaat ggagacagtg      300

accactgatg caggctcggg atgggactgg tacttcgagg tctggggccg cggcaccctg      360

gtcactgtct cctca                                                       375


<210> 946
<211> 125
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region"

<400> 946
Glu Val Gln Leu Val Glu Thr Gly Gly Gly Leu Ile Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Val Ala Ser Gly Phe Ser Leu Arg Asn Tyr 
            20                  25                  30          


Ala Leu Gly Trp Leu Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Gly Gly Tyr Tyr Gly Asp Val Tyr Tyr Thr Asp Ser Val Lys Gly 
    50                  55                  60                  


Arg Phe Ala Val Ser Arg Asp Asn Ser Gly Asp Thr Val Tyr Leu Glu 
65                  70                  75                  80  


Met Asp Asn Leu Arg Val Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
                85                  90                  95      


Met Glu Thr Val Thr Thr Asp Ala Gly Ser Gly Trp Asp Trp Tyr Phe 
            100                 105                 110         


Glu Val Trp Gly Arg Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125 


<210> 947
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H1"

<400> 947
Phe Ser Leu Arg Asn Tyr Ala Leu Gly 
1               5                   


<210> 948
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H1"

<400> 948
ttcagcctta ggaactatgc cttaggt                                           27


<210> 949
<211> 15
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H2"

<400> 949
Gly Gly Tyr Tyr Gly Asp Val Tyr Tyr Thr Asp Ser Val Lys Gly 
1               5                   10                  15  


<210> 950
<211> 45
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H2"

<400> 950
ggtggctatt atggtgatgt ctattacacg gactccgtga agggc                       45


<210> 951
<211> 20
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H3"

<400> 951
Ala Arg Met Glu Thr Val Thr Thr Asp Ala Gly Ser Gly Trp Asp Trp 
1               5                   10                  15      


Tyr Phe Glu Val 
            20  


<210> 952
<211> 60
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H3"

<400> 952
gcgagaatgg agacagtgac cactgatgca ggctcgggat gggactggta cttcgaggtc       60


<210> 953
<211> 324
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region"

<400> 953
gaaacgacac tcacgcagtc tccagccacc ctgtctttgt ctccagggga ttgggccacc       60

ctctcctgca gggccagtca gagtgttggc acctacttag cctggtacca acacaaacct      120

ggccaggctc ccagactcct cattcatgat gcatccaaca gggccagtga catcccatcc      180

aggttcagtg gcagtgggtc tgggacagac ttcactctca ccatccgcgg cctagagcct      240

gaagattttg cagtttatta ctgtcagcaa catcgcgact ggcggccggt cactttcggc      300

ggagggacca aggtggaaat caaa                                             324


<210> 954
<211> 108
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region"

<400> 954
Glu Thr Thr Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Asp Trp Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Gly Thr Tyr 
            20                  25                  30          


Leu Ala Trp Tyr Gln His Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 
        35                  40                  45              


His Asp Ala Ser Asn Arg Ala Ser Asp Ile Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Arg Gly Leu Glu Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln His Arg Asp Trp Arg Pro 
                85                  90                  95      


Val Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105             


<210> 955
<211> 11
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L1"

<400> 955
Arg Ala Ser Gln Ser Val Gly Thr Tyr Leu Ala 
1               5                   10      


<210> 956
<211> 33
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L1"

<400> 956
agggccagtc agagtgttgg cacctactta gcc                                    33


<210> 957
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L2"

<400> 957
Asp Ala Ser Asn Arg Ala Ser 
1               5           


<210> 958
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L2"

<400> 958
gatgcatcca acagggccag t                                                 21


<210> 959
<211> 10
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L3"

<400> 959
Gln Gln His Arg Asp Trp Arg Pro Val Thr 
1               5                   10  


<210> 960
<211> 30
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L3"

<400> 960
cagcaacatc gcgactggcg gccggtcact                                        30


<210> 961
<211> 351
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region"

<400> 961
caggtccagc ttgtgcagtc tggggctgag gcgaagaagc ctggggcctc agtgaaggtc       60

tcctgcacgg cgtctggata caccttcacc aatgatatta actgggtgcg ccaggccact      120

ggacaagggc ttgagtggat ggggtggatg aaccctaaca acggtcacac aggatatgga      180

cagaagttcg aggacagagt caccttgaca agggactcct ccagaagcac agcctacatg      240

gaactgagca gcctgagatt tgaggacacg gccgtgtact attgtgtata caatttttgg      300

agcgattctt cagtcagttg gggccgggga accctggtca ccgtctcctc a               351


<210> 962
<211> 117
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region"

<400> 962
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Ala Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Thr Ala Ser Gly Tyr Thr Phe Thr Asn Asp 
            20                  25                  30          


Ile Asn Trp Val Arg Gln Ala Thr Gly Gln Gly Leu Glu Trp Met Gly 
        35                  40                  45              


Trp Met Asn Pro Asn Asn Gly His Thr Gly Tyr Gly Gln Lys Phe Glu 
    50                  55                  60                  


Asp Arg Val Thr Leu Thr Arg Asp Ser Ser Arg Ser Thr Ala Tyr Met 
65                  70                  75                  80  


Glu Leu Ser Ser Leu Arg Phe Glu Asp Thr Ala Val Tyr Tyr Cys Val 
                85                  90                  95      


Tyr Asn Phe Trp Ser Asp Ser Ser Val Ser Trp Gly Arg Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210> 963
<211> 8
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H1"

<400> 963
Tyr Thr Phe Thr Asn Asp Ile Asn 
1               5               


<210> 964
<211> 24
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H1"

<400> 964
tacaccttca ccaatgatat taac                                              24


<210> 965
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H2"

<400> 965
Trp Met Asn Pro Asn Asn Gly His Thr Gly Tyr Gly Gln Lys Phe Glu 
1               5                   10                  15      


Asp 
    


<210> 966
<211> 51
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H2"

<400> 966
tggatgaacc ctaacaacgg tcacacagga tatggacaga agttcgagga c                51


<210> 967
<211> 11
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H3"

<400> 967
Val Tyr Asn Phe Trp Ser Asp Ser Ser Val Ser 
1               5                   10      


<210> 968
<211> 33
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H3"

<400> 968
gtatacaatt tttggagcga ttcttcagtc agt                                    33


<210> 969
<211> 333
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region"

<400> 969
cagtctgtcg tgacgcagcc gccctcagtg tctggggccc cagggcagag tgtcgccatc       60

tcctgcactg ggagcagctc caacatcggg ccagcctatg atgtacactg gtaccagcag      120

actccgggag cagcccccaa actcctcatc tatggtgaca gcaatcggcc ctcaggggtc      180

cctgaccgat tctctacctc caagtctggc acctcagcct ccctggccat cactgggctc      240

caggctgagg atgaggctga ttattactgc cagtcctttg acagcagcct gcgtggttat      300

gtcttcggaa ctgggaccaa ggtgaccgtc cta                                   333


<210> 970
<211> 111
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region"

<400> 970
Gln Ser Val Val Thr Gln Pro Pro Ser Val Ser Gly Ala Pro Gly Gln 
1               5                   10                  15      


Ser Val Ala Ile Ser Cys Thr Gly Ser Ser Ser Asn Ile Gly Pro Ala 
            20                  25                  30          


Tyr Asp Val His Trp Tyr Gln Gln Thr Pro Gly Ala Ala Pro Lys Leu 
        35                  40                  45              


Leu Ile Tyr Gly Asp Ser Asn Arg Pro Ser Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Thr Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Thr Gly Leu 
65                  70                  75                  80  


Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Gln Ser Phe Asp Ser Ser 
                85                  90                  95      


Leu Arg Gly Tyr Val Phe Gly Thr Gly Thr Lys Val Thr Val Leu 
            100                 105                 110     


<210> 971
<211> 14
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L1"

<400> 971
Thr Gly Ser Ser Ser Asn Ile Gly Pro Ala Tyr Asp Val His 
1               5                   10                  


<210> 972
<211> 42
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L1"

<400> 972
actgggagca gctccaacat cgggccagcc tatgatgtac ac                          42


<210> 973
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L2"

<400> 973
Gly Asp Ser Asn Arg Pro Ser 
1               5           


<210> 974
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L2"

<400> 974
ggtgacagca atcggccctc a                                                 21


<210> 975
<211> 11
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L3"

<400> 975
Gln Ser Phe Asp Ser Ser Leu Arg Gly Tyr Val 
1               5                   10      


<210> 976
<211> 33
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L3"

<400> 976
cagtcctttg acagcagcct gcgtggttat gtc                                    33


<210> 977
<211> 369
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region"

<400> 977
caggtccagc tggtgcagtc tggggctgag gtgaagaagc ctggggcctc agtgaaggtc       60

tcctgcaagg cttctggata caccttcacc agttatgata tcaactgggt gcgacaggcc      120

actggacatg ggcttgagtg gatgggatgg atgagcccta acagtggtta cacaggctat      180

gcacagaagt tccagggcag agtcaccatg agcaggaaca cctccacagg cacagcctac      240

atggagctga gcagcctgag atctgaggac acggccgtgt attactgtgc gagagaggcc      300

cgggacctac gagtgggagc tactaacttt gactactggg gccagggaac cctggtcacc      360

gtctcctca                                                              369


<210> 978
<211> 123
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region"

<400> 978
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Asp Ile Asn Trp Val Arg Gln Ala Thr Gly His Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Met Ser Pro Asn Ser Gly Tyr Thr Gly Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Met Ser Arg Asn Thr Ser Thr Gly Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Glu Ala Arg Asp Leu Arg Val Gly Ala Thr Asn Phe Asp Tyr 
            100                 105                 110         


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120             


<210> 979
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H1"

<400> 979
Tyr Thr Phe Thr Ser Tyr Asp Ile Asn 
1               5                   


<210> 980
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H1"

<400> 980
tacaccttca ccagttatga tatcaac                                           27


<210> 981
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H2"

<400> 981
Trp Met Ser Pro Asn Ser Gly Tyr Thr Gly Tyr Ala Gln Lys Phe Gln 
1               5                   10                  15      


Gly 
    


<210> 982
<211> 51
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H2"

<400> 982
tggatgagcc ctaacagtgg ttacacaggc tatgcacaga agttccaggg c                51


<210> 983
<211> 16
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H3"

<400> 983
Ala Arg Glu Ala Arg Asp Leu Arg Val Gly Ala Thr Asn Phe Asp Tyr 
1               5                   10                  15      


<210> 984
<211> 48
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H3"

<400> 984
gcgagagagg cccgggacct acgagtggga gctactaact ttgactac                    48


<210> 985
<211> 321
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region"

<400> 985
cagcctgtgc tgactcagcc accctcagtg tccgtgtccc caggacagac agccagcata       60

acctgctctg gagataaatt gggagataaa tatatttcgt ggtatcaaca gaggccaggc      120

cagtcccctg taatggtaat ttatcaagat agcaaggggc cctcagggat ccctgagcga      180

ttctctggct ccaactctgg gaacacagcc actctgacca tcagcgggac gcaggctatg      240

gatgaggctg actattactg tcaggcgtgg gacagcagca tagatgtggt attcggcgga      300

gggaccaagc tcaccgtcct a                                                321


<210> 986
<211> 107
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region"

<400> 986
Gln Pro Val Leu Thr Gln Pro Pro Ser Val Ser Val Ser Pro Gly Gln 
1               5                   10                  15      


Thr Ala Ser Ile Thr Cys Ser Gly Asp Lys Leu Gly Asp Lys Tyr Ile 
            20                  25                  30          


Ser Trp Tyr Gln Gln Arg Pro Gly Gln Ser Pro Val Met Val Ile Tyr 
        35                  40                  45              


Gln Asp Ser Lys Gly Pro Ser Gly Ile Pro Glu Arg Phe Ser Gly Ser 
    50                  55                  60                  


Asn Ser Gly Asn Thr Ala Thr Leu Thr Ile Ser Gly Thr Gln Ala Met 
65                  70                  75                  80  


Asp Glu Ala Asp Tyr Tyr Cys Gln Ala Trp Asp Ser Ser Ile Asp Val 
                85                  90                  95      


Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105         


<210> 987
<211> 11
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L1"

<400> 987
Ser Gly Asp Lys Leu Gly Asp Lys Tyr Ile Ser 
1               5                   10      


<210> 988
<211> 33
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L1"

<400> 988
tctggagata aattgggaga taaatatatt tcg                                    33


<210> 989
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L2"

<400> 989
Gln Asp Ser Lys Gly Pro Ser 
1               5           


<210> 990
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L2"

<400> 990
caagatagca aggggccctc a                                                 21


<210> 991
<211> 10
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L3"

<400> 991
Gln Ala Trp Asp Ser Ser Ile Asp Val Val 
1               5                   10  


<210> 992
<211> 30
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L3"

<400> 992
caggcgtggg acagcagcat agatgtggta                                        30


<210> 993
<211> 372
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region"

<400> 993
caggtccagc tggtgcagtc tgggcctgag atgaagaagc ctgggtcctc cgtgaaggtc       60

tcctgcaagc cttctggagg caccttcagc agctactctg tcagctgggt gcgacaggcc      120

cctggacaag ggcttgagtg gatgggagga atcatcccga tatttggttc gtcagactac      180

gcacagaagt ttcagggcag actcacaatt acagaggacg aatccacgaa gacatcctac      240

atgcagctga acaacctgac atctgacgac acggccattt atttctgtgc gagagacaac      300

tactatgttt ggactggtca ctatcccgaa tttgacttct ggggccaggg aaccctggtc      360

accgtctcct ca                                                          372


<210> 994
<211> 124
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region"

<400> 994
Gln Val Gln Leu Val Gln Ser Gly Pro Glu Met Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Pro Ser Gly Gly Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ser Val Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Gly Ile Ile Pro Ile Phe Gly Ser Ser Asp Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Leu Thr Ile Thr Glu Asp Glu Ser Thr Lys Thr Ser Tyr 
65                  70                  75                  80  


Met Gln Leu Asn Asn Leu Thr Ser Asp Asp Thr Ala Ile Tyr Phe Cys 
                85                  90                  95      


Ala Arg Asp Asn Tyr Tyr Val Trp Thr Gly His Tyr Pro Glu Phe Asp 
            100                 105                 110         


Phe Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 


<210> 995
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H1"

<400> 995
Gly Thr Phe Ser Ser Tyr Ser Val Ser 
1               5                   


<210> 996
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H1"

<400> 996
ggcaccttca gcagctactc tgtcagc                                           27


<210> 997
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H2"

<400> 997
Gly Ile Ile Pro Ile Phe Gly Ser Ser Asp Tyr Ala Gln Lys Phe Gln 
1               5                   10                  15      


Gly 
    


<210> 998
<211> 51
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H2"

<400> 998
ggaatcatcc cgatatttgg ttcgtcagac tacgcacaga agtttcaggg c                51


<210> 999
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H3"

<400> 999
Ala Arg Asp Asn Tyr Tyr Val Trp Thr Gly His Tyr Pro Glu Phe Asp 
1               5                   10                  15      


Phe 
    


<210> 1000
<211> 51
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H3"

<400> 1000
gcgagagaca actactatgt ttggactggt cactatcccg aatttgactt c                51


<210> 1001
<211> 324
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region"

<400> 1001
gaaacgacac tcacgcagtc tccaggcacc ctgtccttgt ctctagggga gactgccacc       60

ctctcctgca gggccagtca gagtgtgaga agcgattact tagcctggta ccaacagaaa      120

ccaggccagg ctcccaggct cctcatctct ggtgcatcca acagggccac tgccatccca      180

gagaggttca ctggcagtgg gtctgggaca gacttcactc tcaccatcag cagcctggag      240

cctgcagatt ttgcagtgta ttattgtcag cagtatggta gcacaccgat caccttcggc      300

caggggacac gactggagat taaa                                             324


<210> 1002
<211> 108
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region"

<400> 1002
Glu Thr Thr Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Leu Gly 
1               5                   10                  15      


Glu Thr Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Arg Ser Asp 
            20                  25                  30          


Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu 
        35                  40                  45              


Ile Ser Gly Ala Ser Asn Arg Ala Thr Ala Ile Pro Glu Arg Phe Thr 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu 
65                  70                  75                  80  


Pro Ala Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Gly Ser Thr Pro 
                85                  90                  95      


Ile Thr Phe Gly Gln Gly Thr Arg Leu Glu Ile Lys 
            100                 105             


<210> 1003
<211> 12
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L1"

<400> 1003
Arg Ala Ser Gln Ser Val Arg Ser Asp Tyr Leu Ala 
1               5                   10          


<210> 1004
<211> 36
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L1"

<400> 1004
agggccagtc agagtgtgag aagcgattac ttagcc                                 36


<210> 1005
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L2"

<400> 1005
Gly Ala Ser Asn Arg Ala Thr 
1               5           


<210> 1006
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L2"

<400> 1006
ggtgcatcca acagggccac t                                                 21


<210> 1007
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L3"

<400> 1007
Gln Gln Tyr Gly Ser Thr Pro Ile Thr 
1               5                   


<210> 1008
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L3"

<400> 1008
cagcagtatg gtagcacacc gatcacc                                           27


<210> 1009
<211> 387
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region"

<400> 1009
caggtgcagc tgcaggagtc ggggggaggc ttggtacagc ctggggggtc cctgagactc       60

tcctgttcag cctctggatt cacctttagt aactatggca tgagttgggt ccgccaggct      120

ccagggaagg ggctggagtg ggtctcaggt attggtgtga gtgatggaag cacacactac      180

gcggactccg tgaagggccg gttcatcatc tccagagaca attccaagaa catgctgtct      240

ctgcaaatga gcagcctggg agtcgacgac acggccgtat attactgtgc gagaattgta      300

attgttggag tattacgatt tcaggagtgg ttatcatctg acgggatgga cgtctggggc      360

caagggacca cggtcaccgt ctcctca                                          387


<210> 1010
<211> 129
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region"

<400> 1010
Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ser Ala Ser Gly Phe Thr Phe Ser Asn Tyr 
            20                  25                  30          


Gly Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Gly Ile Gly Val Ser Asp Gly Ser Thr His Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Ile Ile Ser Arg Asp Asn Ser Lys Asn Met Leu Ser 
65                  70                  75                  80  


Leu Gln Met Ser Ser Leu Gly Val Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ile Val Ile Val Gly Val Leu Arg Phe Gln Glu Trp Leu Ser 
            100                 105                 110         


Ser Asp Gly Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser 
        115                 120                 125             


Ser 
    


<210> 1011
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H1"

<400> 1011
Phe Thr Phe Ser Asn Tyr Gly Met Ser 
1               5                   


<210> 1012
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H1"

<400> 1012
ttcaccttta gtaactatgg catgagt                                           27


<210> 1013
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H2"

<400> 1013
Gly Ile Gly Val Ser Asp Gly Ser Thr His Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210> 1014
<211> 51
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H2"

<400> 1014
ggtattggtg tgagtgatgg aagcacacac tacgcggact ccgtgaaggg c                51


<210> 1015
<211> 22
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H3"

<400> 1015
Ala Arg Ile Val Ile Val Gly Val Leu Arg Phe Gln Glu Trp Leu Ser 
1               5                   10                  15      


Ser Asp Gly Met Asp Val 
            20          


<210> 1016
<211> 66
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H3"

<400> 1016
gcgagaattg taattgttgg agtattacga tttcaggagt ggttatcatc tgacgggatg       60

gacgtc                                                                  66


<210> 1017
<211> 321
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region"

<400> 1017
gatattgtga tgacccagac tccatcttcc gtgtctgcat ctgtaggaga cagagtcacg       60

atcacttgtc gggcgagtca ggccattagt ggcgggttag cctggtatca gcagaaagca      120

ggaaaagccc ctaaactcct gatctatgct gcatccaatt tgccaagtgg ggtcccatca      180

aggttcagcg gcagtggatc tgggacagat ttcactctca ccatcagcag cctgcagcct      240

gaggattttg cgacttatta ttgtcaacag gctaacagtt tccccttcac cttcggccaa      300

gggacacgac tggagattaa a                                                321


<210> 1018
<211> 107
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region"

<400> 1018
Asp Ile Val Met Thr Gln Thr Pro Ser Ser Val Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ala Ile Ser Gly Gly 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Ala Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Asn Leu Pro Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ala Asn Ser Phe Pro Phe 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Arg Leu Glu Ile Lys 
            100                 105         


<210> 1019
<211> 11
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L1"

<400> 1019
Arg Ala Ser Gln Ala Ile Ser Gly Gly Leu Ala 
1               5                   10      


<210> 1020
<211> 33
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L1"

<400> 1020
cgggcgagtc aggccattag tggcgggtta gcc                                    33


<210> 1021
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L2"

<400> 1021
Ala Ala Ser Asn Leu Pro Ser 
1               5           


<210> 1022
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L2"

<400> 1022
gctgcatcca atttgccaag t                                                 21


<210> 1023
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L3"

<400> 1023
Gln Gln Ala Asn Ser Phe Pro Phe Thr 
1               5                   


<210> 1024
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L3"

<400> 1024
caacaggcta acagtttccc cttcacc                                           27


<210> 1025
<211> 357
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region"

<400> 1025
gaggtgcagc tgttggagtc tgggggaggc ctggtcaagc ctggggggtc cctgagactc       60

tcctgtgcag cctcgggatt caccatcggt ggttataaca tgttctgggt ccgccagcct      120

ccggggaagg ggctggagtg ggtctcatcc attactgctg gtagtagtta tttaaactat      180

gcagactcag tgaagggccg tttcatcgtc tccagagaca acgccaagaa ttcactgtat      240

ctgcaaatga acagcctgag agccgaggac acggctgttt atttctgtgc gagagcacct      300

cttttacccg ctatgatgga cctctggggc caagggacca cggtcaccgt ctcctca         357


<210> 1026
<211> 119
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region"

<400> 1026
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Ile Gly Gly Tyr 
            20                  25                  30          


Asn Met Phe Trp Val Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ser Ile Thr Ala Gly Ser Ser Tyr Leu Asn Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Ile Val Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Phe Cys 
                85                  90                  95      


Ala Arg Ala Pro Leu Leu Pro Ala Met Met Asp Leu Trp Gly Gln Gly 
            100                 105                 110         


Thr Thr Val Thr Val Ser Ser 
        115                 


<210> 1027
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H1"

<400> 1027
Phe Thr Ile Gly Gly Tyr Asn Met Phe 
1               5                   


<210> 1028
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H1"

<400> 1028
ttcaccatcg gtggttataa catgttc                                           27


<210> 1029
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H2"

<400> 1029
Ser Ile Thr Ala Gly Ser Ser Tyr Leu Asn Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210> 1030
<211> 51
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H2"

<400> 1030
tccattactg ctggtagtag ttatttaaac tatgcagact cagtgaaggg c                51


<210> 1031
<211> 12
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H3"

<400> 1031
Ala Arg Ala Pro Leu Leu Pro Ala Met Met Asp Leu 
1               5                   10          


<210> 1032
<211> 36
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H3"

<400> 1032
gcgagagcac ctcttttacc cgctatgatg gacctc                                 36


<210> 1033
<211> 333
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region"

<400> 1033
cagtctgtgg tgacgcagcc gccctcagtg tctggggccc cagggcagag ggtcaccatc       60

tcctgcactg ggagcagctc caacatcggg gcaggttatg atgtacactg gtaccagcaa      120

cttccaggaa cagcccccaa actcctcatc tatactaaca acaatcggcc ctcaggggtc      180

cctgaccgat tctctggctc caagtctggc acctcagcct ccctggccat cactgggctc      240

caggctgagg atgaggctga ctattactgc cagtcctatg acagaagcct gaatggttat      300

gtcttcggaa ctggcaccca gctgaccgtc ctc                                   333


<210> 1034
<211> 111
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region"

<400> 1034
Gln Ser Val Val Thr Gln Pro Pro Ser Val Ser Gly Ala Pro Gly Gln 
1               5                   10                  15      


Arg Val Thr Ile Ser Cys Thr Gly Ser Ser Ser Asn Ile Gly Ala Gly 
            20                  25                  30          


Tyr Asp Val His Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu 
        35                  40                  45              


Leu Ile Tyr Thr Asn Asn Asn Arg Pro Ser Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Thr Gly Leu 
65                  70                  75                  80  


Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Gln Ser Tyr Asp Arg Ser 
                85                  90                  95      


Leu Asn Gly Tyr Val Phe Gly Thr Gly Thr Gln Leu Thr Val Leu 
            100                 105                 110     


<210> 1035
<211> 14
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L1"

<400> 1035
Thr Gly Ser Ser Ser Asn Ile Gly Ala Gly Tyr Asp Val His 
1               5                   10                  


<210> 1036
<211> 42
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L1"

<400> 1036
actgggagca gctccaacat cggggcaggt tatgatgtac ac                          42


<210> 1037
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L2"

<400> 1037
Thr Asn Asn Asn Arg Pro Ser 
1               5           


<210> 1038
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L2"

<400> 1038
actaacaaca atcggccctc a                                                 21


<210> 1039
<211> 11
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L3"

<400> 1039
Gln Ser Tyr Asp Arg Ser Leu Asn Gly Tyr Val 
1               5                   10      


<210> 1040
<211> 33
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L3"

<400> 1040
cagtcctatg acagaagcct gaatggttat gtc                                    33


<210> 1041
<211> 363
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region"

<400> 1041
caggtccagc ttgtacagtc tgggggaggc ttggtcaagg ctggagggtc cctgagactc       60

tcctgtgcag cctctggatt caccatcagt ggcttctaca tgacctggat ccgccaggct      120

ccagggaagg ggctggagtg ggtttcatcc attagtggta gtagtagtta cacaaactac      180

gcagactctg tgaagggccg attcaccatc tccagagaca acgccaagaa ctcactgtat      240

ctgcacatga acagcctgag agccgaggac acggctgtat attactgtgc gagaataagg      300

ccggatgata gtagtggtta tcctgactac tggggccagg gaaccctggt caccgtctcc      360

tca                                                                    363


<210> 1042
<211> 121
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region"

<400> 1042
Gln Val Gln Leu Val Gln Ser Gly Gly Gly Leu Val Lys Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Ile Ser Gly Phe 
            20                  25                  30          


Tyr Met Thr Trp Ile Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ser Ile Ser Gly Ser Ser Ser Tyr Thr Asn Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu His Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ile Arg Pro Asp Asp Ser Ser Gly Tyr Pro Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120     


<210> 1043
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H1"

<400> 1043
Phe Thr Ile Ser Gly Phe Tyr Met Thr 
1               5                   


<210> 1044
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H1"

<400> 1044
ttcaccatca gtggcttcta catgacc                                           27


<210> 1045
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H2"

<400> 1045
Ser Ile Ser Gly Ser Ser Ser Tyr Thr Asn Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210> 1046
<211> 51
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H2"

<400> 1046
tccattagtg gtagtagtag ttacacaaac tacgcagact ctgtgaaggg c                51


<210> 1047
<211> 14
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H3"

<400> 1047
Ala Arg Ile Arg Pro Asp Asp Ser Ser Gly Tyr Pro Asp Tyr 
1               5                   10                  


<210> 1048
<211> 42
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H3"

<400> 1048
gcgagaataa ggccggatga tagtagtggt tatcctgact ac                          42


<210> 1049
<211> 333
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region"

<400> 1049
cagtctgtgt tgacgcagcc gccctcagtg tctggggccc cagggcagag ggtcaccatc       60

tcctgcactg ggagcagctc caacatcggg gctggttatg atgtacactg gtgccagcag      120

cttccaggaa cagcccccaa actcctcatc tatggtaaca acaatcggcc ctcaggggtc      180

cctgaccgat tctctggctc caagtctggc acctcagcct ccctggccat cactgggctc      240

caggctgagg atgaggctga ttattactgc cagtcctatg acagcagcct gagtggcttt      300

gtcttcggaa ctgggaccaa ggtgaccgtc cta                                   333


<210> 1050
<211> 111
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region"

<400> 1050
Gln Ser Val Leu Thr Gln Pro Pro Ser Val Ser Gly Ala Pro Gly Gln 
1               5                   10                  15      


Arg Val Thr Ile Ser Cys Thr Gly Ser Ser Ser Asn Ile Gly Ala Gly 
            20                  25                  30          


Tyr Asp Val His Trp Cys Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu 
        35                  40                  45              


Leu Ile Tyr Gly Asn Asn Asn Arg Pro Ser Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Thr Gly Leu 
65                  70                  75                  80  


Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Gln Ser Tyr Asp Ser Ser 
                85                  90                  95      


Leu Ser Gly Phe Val Phe Gly Thr Gly Thr Lys Val Thr Val Leu 
            100                 105                 110     


<210> 1051
<211> 14
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L1"

<400> 1051
Thr Gly Ser Ser Ser Asn Ile Gly Ala Gly Tyr Asp Val His 
1               5                   10                  


<210> 1052
<211> 42
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L1"

<400> 1052
actgggagca gctccaacat cggggctggt tatgatgtac ac                          42


<210> 1053
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L2"

<400> 1053
Gly Asn Asn Asn Arg Pro Ser 
1               5           


<210> 1054
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L2"

<400> 1054
ggtaacaaca atcggccctc a                                                 21


<210> 1055
<211> 11
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L3"

<400> 1055
Gln Ser Tyr Asp Ser Ser Leu Ser Gly Phe Val 
1               5                   10      


<210> 1056
<211> 33
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L3"

<400> 1056
cagtcctatg acagcagcct gagtggcttt gtc                                    33


<210> 1057
<211> 378
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region"

<400> 1057
gaggtgcagc tggtggagtc tggggctgag gtgaggaagc ctggggcctc agtgcaggtt       60

tcctgcaagg catctggata caccttcacc agctactata tgcactgggt gcgacaggcc      120

cctggacacg ggcttgagtg gatgggaatg atctacccta gtggtggtag cacaagctac      180

gcacagaagt tccagggcag agtcaccatg accagggaca cgtccacgag cacagtctac      240

atggagctga gcagcctgag atctgaggac gcggccgtgt attactgtgc gagagaccgg      300

gcagggtgta gtggtggtag ctgttactat tatggtatgg acgtctgggg ccaagggacc      360

acggtcaccg tctcctca                                                    378


<210> 1058
<211> 126
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region"

<400> 1058
Glu Val Gln Leu Val Glu Ser Gly Ala Glu Val Arg Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Gln Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Tyr Met His Trp Val Arg Gln Ala Pro Gly His Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Met Ile Tyr Pro Ser Gly Gly Ser Thr Ser Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Met Thr Arg Asp Thr Ser Thr Ser Thr Val Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Ala Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Arg Ala Gly Cys Ser Gly Gly Ser Cys Tyr Tyr Tyr Gly 
            100                 105                 110         


Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120                 125     


<210> 1059
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H1"

<400> 1059
Tyr Thr Phe Thr Ser Tyr Tyr Met His 
1               5                   


<210> 1060
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H1"

<400> 1060
tacaccttca ccagctacta tatgcac                                           27


<210> 1061
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H2"

<400> 1061
Met Ile Tyr Pro Ser Gly Gly Ser Thr Ser Tyr Ala Gln Lys Phe Gln 
1               5                   10                  15      


Gly 
    


<210> 1062
<211> 51
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H2"

<400> 1062
atgatctacc ctagtggtgg tagcacaagc tacgcacaga agttccaggg c                51


<210> 1063
<211> 19
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H3"

<400> 1063
Ala Arg Asp Arg Ala Gly Cys Ser Gly Gly Ser Cys Tyr Tyr Tyr Gly 
1               5                   10                  15      


Met Asp Val 
            


<210> 1064
<211> 57
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H3"

<400> 1064
gcgagagacc gggcagggtg tagtggtggt agctgttact attatggtat ggacgtc          57


<210> 1065
<211> 318
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region"

<400> 1065
aattttatgc tgactcagcc cccctcagtg tccgtgtccc caggacagac agccagcatc       60

acctgctctg gaaataaatt gggggataaa tatgcttgct ggtatcaaca aaagccaggc      120

cagtcccctg tgctggtcat ctctcaagat agcaagcggc cctcagggat ccctgagcga      180

ttctctggct ccaactctgg gaacacagcc actctgacca tcagcgggac ccaggctatg      240

gatgaggctg actattactg tcaggcgtgg gacagtagaa ctgttgtatt cggcggaggg      300

accaagctga ccgtccta                                                    318


<210> 1066
<211> 106
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region"

<400> 1066
Asn Phe Met Leu Thr Gln Pro Pro Ser Val Ser Val Ser Pro Gly Gln 
1               5                   10                  15      


Thr Ala Ser Ile Thr Cys Ser Gly Asn Lys Leu Gly Asp Lys Tyr Ala 
            20                  25                  30          


Cys Trp Tyr Gln Gln Lys Pro Gly Gln Ser Pro Val Leu Val Ile Ser 
        35                  40                  45              


Gln Asp Ser Lys Arg Pro Ser Gly Ile Pro Glu Arg Phe Ser Gly Ser 
    50                  55                  60                  


Asn Ser Gly Asn Thr Ala Thr Leu Thr Ile Ser Gly Thr Gln Ala Met 
65                  70                  75                  80  


Asp Glu Ala Asp Tyr Tyr Cys Gln Ala Trp Asp Ser Arg Thr Val Val 
                85                  90                  95      


Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105     


<210> 1067
<211> 11
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L1"

<400> 1067
Ser Gly Asn Lys Leu Gly Asp Lys Tyr Ala Cys 
1               5                   10      


<210> 1068
<211> 33
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L1"

<400> 1068
tctggaaata aattggggga taaatatgct tgc                                    33


<210> 1069
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L2"

<400> 1069
Gln Asp Ser Lys Arg Pro Ser 
1               5           


<210> 1070
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L2"

<400> 1070
caagatagca agcggccctc a                                                 21


<210> 1071
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L3"

<400> 1071
Gln Ala Trp Asp Ser Arg Thr Val Val 
1               5                   


<210> 1072
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L3"

<400> 1072
caggcgtggg acagtagaac tgttgta                                           27


<210> 1073
<211> 381
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region"

<400> 1073
gaggtgcagc tggtggagtc tggggctgag gtgaagaagc ctgggtcctc ggtgaaggtc       60

tcctgcaagg cttctggagg caccttcagt agttatgaaa tcagctgggt gcgacaggcc      120

cctggacaag gacttgagtg gatgggaggg atcaacccta tgtttggagc agcaaactac      180

gcacagaagt tccaggacag agtcacgatt atcgcggaca aatccacggg cacagtctac      240

atggaactga gcagcctgag atctgaggac acggccctct attactgtgc gagagaacgc      300

tacccgtcta cggatgacta ttataggagt ggtcgttact acggggagtg gggccagggg      360

accacggtca ccgtctcctc a                                                381


<210> 1074
<211> 127
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region"

<400> 1074
Glu Val Gln Leu Val Glu Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Ser Tyr 
            20                  25                  30          


Glu Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Gly Ile Asn Pro Met Phe Gly Ala Ala Asn Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Asp Arg Val Thr Ile Ile Ala Asp Lys Ser Thr Gly Thr Val Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Leu Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Glu Arg Tyr Pro Ser Thr Asp Asp Tyr Tyr Arg Ser Gly Arg 
            100                 105                 110         


Tyr Tyr Gly Glu Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120                 125         


<210> 1075
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H1"

<400> 1075
Gly Thr Phe Ser Ser Tyr Glu Ile Ser 
1               5                   


<210> 1076
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H1"

<400> 1076
ggcaccttca gtagttatga aatcagc                                           27


<210> 1077
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H2"

<400> 1077
Gly Ile Asn Pro Met Phe Gly Ala Ala Asn Tyr Ala Gln Lys Phe Gln 
1               5                   10                  15      


Asp 
    


<210> 1078
<211> 51
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H2"

<400> 1078
gggatcaacc ctatgtttgg agcagcaaac tacgcacaga agttccagga c                51


<210> 1079
<211> 20
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H3"

<400> 1079
Ala Arg Glu Arg Tyr Pro Ser Thr Asp Asp Tyr Tyr Arg Ser Gly Arg 
1               5                   10                  15      


Tyr Tyr Gly Glu 
            20  


<210> 1080
<211> 60
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H3"

<400> 1080
gcgagagaac gctacccgtc tacggatgac tattatagga gtggtcgtta ctacggggag       60


<210> 1081
<211> 321
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region"

<400> 1081
gaaacgacac tcacgcagtc tccttccacc ctgtctgcat ctgtaggaga cagagtcacc       60

atcacttgcc gggccagtca gagtattcgt agttggttgg cctggtatca gcagaaacca      120

gggaaagccc cgaagctcct gatctatagg gcgtctactt cagacagtgg ggtcccatca      180

aggttcagcg gcagtggatc tgggacagaa ttcacgctca ccatcagcag cctgcagcct      240

gatgattttg caatttatta ctgccaacag tataatagca tcccagtgac gttcggccaa      300

gggaccaagc tggagatcaa a                                                321


<210> 1082
<211> 107
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region"

<400> 1082
Glu Thr Thr Leu Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Arg Ser Trp 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Arg Ala Ser Thr Ser Asp Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Asp Asp Phe Ala Ile Tyr Tyr Cys Gln Gln Tyr Asn Ser Ile Pro Val 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210> 1083
<211> 11
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L1"

<400> 1083
Arg Ala Ser Gln Ser Ile Arg Ser Trp Leu Ala 
1               5                   10      


<210> 1084
<211> 33
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L1"

<400> 1084
cgggccagtc agagtattcg tagttggttg gcc                                    33


<210> 1085
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L2"

<400> 1085
Arg Ala Ser Thr Ser Asp Ser 
1               5           


<210> 1086
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L2"

<400> 1086
agggcgtcta cttcagacag t                                                 21


<210> 1087
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L3"

<400> 1087
Gln Gln Tyr Asn Ser Ile Pro Val Thr 
1               5                   


<210> 1088
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L3"

<400> 1088
caacagtata atagcatccc agtgacg                                           27


<210> 1089
<211> 369
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region"

<400> 1089
gaggtgcagc tggtggagtc tgggggaggc gtggtccagc ctgggaggtc cctgagactc       60

tcctgtgcag cgtctggatt cacattcagt gactatgcca tgcactgggt ccgccaggct      120

ccaggcaagg ggctggagtg ggtggcagtt atatggtatg atggaggtaa taaatactat      180

gcagactccg cgaagggccg attcaccatc tccagagaca attccaagaa cacgctgtat      240

ctgcaaatga acagcctgag agccgaggac acggctgtgt attactgtgc gaaagatcgc      300

gggtctatct ggaacgttgg ggatggtatg gacgtctggg gccaagggac cacggtcacc      360

gtctcttca                                                              369


<210> 1090
<211> 123
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region"

<400> 1090
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp Tyr 
            20                  25                  30          


Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Val Ile Trp Tyr Asp Gly Gly Asn Lys Tyr Tyr Ala Asp Ser Ala 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Asp Arg Gly Ser Ile Trp Asn Val Gly Asp Gly Met Asp Val 
            100                 105                 110         


Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120             


<210> 1091
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H1"

<400> 1091
Phe Thr Phe Ser Asp Tyr Ala Met His 
1               5                   


<210> 1092
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H1"

<400> 1092
ttcacattca gtgactatgc catgcac                                           27


<210> 1093
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H2"

<400> 1093
Val Ile Trp Tyr Asp Gly Gly Asn Lys Tyr Tyr Ala Asp Ser Ala Lys 
1               5                   10                  15      


Gly 
    


<210> 1094
<211> 51
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H2"

<400> 1094
gttatatggt atgatggagg taataaatac tatgcagact ccgcgaaggg c                51


<210> 1095
<211> 16
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H3"

<400> 1095
Ala Lys Asp Arg Gly Ser Ile Trp Asn Val Gly Asp Gly Met Asp Val 
1               5                   10                  15      


<210> 1096
<211> 48
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H3"

<400> 1096
gcgaaagatc gcgggtctat ctggaacgtt ggggatggta tggacgtc                    48


<210> 1097
<211> 327
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region"

<400> 1097
cagcctgtgc tgactcagcc accctcggtg tcagtggccc caggacagac ggccagggtt       60

acctgtgggg gaaacaacat tggagctaag agtgtccact ggtaccagca gaagccaggc      120

caggcccctg tgctggtcgt cgatgatgat accgaccggc cctcagggat ccctgagcga      180

ttctctggct ccaactctgg gaacacggcc accctgacca tcagcagggt cgaagccggg      240

gatgaggccg actattactg tcaggtgtgg gatgctagta ttggtcctct ttatgtcttc      300

ggaactggga ccaagctcac cgtccta                                          327


<210> 1098
<211> 109
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region"

<400> 1098
Gln Pro Val Leu Thr Gln Pro Pro Ser Val Ser Val Ala Pro Gly Gln 
1               5                   10                  15      


Thr Ala Arg Val Thr Cys Gly Gly Asn Asn Ile Gly Ala Lys Ser Val 
            20                  25                  30          


His Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Val Leu Val Val Asp 
        35                  40                  45              


Asp Asp Thr Asp Arg Pro Ser Gly Ile Pro Glu Arg Phe Ser Gly Ser 
    50                  55                  60                  


Asn Ser Gly Asn Thr Ala Thr Leu Thr Ile Ser Arg Val Glu Ala Gly 
65                  70                  75                  80  


Asp Glu Ala Asp Tyr Tyr Cys Gln Val Trp Asp Ala Ser Ile Gly Pro 
                85                  90                  95      


Leu Tyr Val Phe Gly Thr Gly Thr Lys Leu Thr Val Leu 
            100                 105                 


<210> 1099
<211> 11
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L1"

<400> 1099
Gly Gly Asn Asn Ile Gly Ala Lys Ser Val His 
1               5                   10      


<210> 1100
<211> 33
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L1"

<400> 1100
gggggaaaca acattggagc taagagtgtc cac                                    33


<210> 1101
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L2"

<400> 1101
Asp Asp Thr Asp Arg Pro Ser 
1               5           


<210> 1102
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L2"

<400> 1102
gatgataccg accggccctc a                                                 21


<210> 1103
<211> 12
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L3"

<400> 1103
Gln Val Trp Asp Ala Ser Ile Gly Pro Leu Tyr Val 
1               5                   10          


<210> 1104
<211> 36
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L3"

<400> 1104
caggtgtggg atgctagtat tggtcctctt tatgtc                                 36


<210> 1105
<211> 372
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region"

<400> 1105
caggtccagc tggtgcagtc tgggggaggc gtggtccagc ctgggaggtc cctgagactc       60

tcctgtgcag cctctggttt caccttcagt gacttttcta tgcactgggt ccgccaggct      120

ccaggcaagg ggctggagtg ggtggcactc atctcaaatg atggaagcaa taaatattat      180

tcagactccc tgaagggttc attcatcatc tccagagaca actccaagaa cacgctctat      240

ctccaactga acagcctggg agctgaggac acggctctgt attactgtgc gagagatgcg      300

gttccccatt atgattacgt ctggggaaac tttgactact ggggcccggg aaccctggtc      360

accgtctcct ca                                                          372


<210> 1106
<211> 124
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region"

<400> 1106
Gln Val Gln Leu Val Gln Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp Phe 
            20                  25                  30          


Ser Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Leu Ile Ser Asn Asp Gly Ser Asn Lys Tyr Tyr Ser Asp Ser Leu 
    50                  55                  60                  


Lys Gly Ser Phe Ile Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Leu Asn Ser Leu Gly Ala Glu Asp Thr Ala Leu Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Ala Val Pro His Tyr Asp Tyr Val Trp Gly Asn Phe Asp 
            100                 105                 110         


Tyr Trp Gly Pro Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 


<210> 1107
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H1"

<400> 1107
Phe Thr Phe Ser Asp Phe Ser Met His 
1               5                   


<210> 1108
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H1"

<400> 1108
ttcaccttca gtgacttttc tatgcac                                           27


<210> 1109
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H2"

<400> 1109
Leu Ile Ser Asn Asp Gly Ser Asn Lys Tyr Tyr Ser Asp Ser Leu Lys 
1               5                   10                  15      


Gly 
    


<210> 1110
<211> 51
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H2"

<400> 1110
ctcatctcaa atgatggaag caataaatat tattcagact ccctgaaggg t                51


<210> 1111
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H3"

<400> 1111
Ala Arg Asp Ala Val Pro His Tyr Asp Tyr Val Trp Gly Asn Phe Asp 
1               5                   10                  15      


Tyr 
    


<210> 1112
<211> 51
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H3"

<400> 1112
gcgagagatg cggttcccca ttatgattac gtctggggaa actttgacta c                51


<210> 1113
<211> 330
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region"

<400> 1113
cagcctgtgc tgactcagcc tgcctccgtg tctgcgtctc ctggacagtc gatcaccatc       60

tcctgcactg gaaccagcag tgacgttggt ggttataatt atgtctcctg gtaccaacag      120

cacccaggca aagcccccaa actcatagtt tatgaggtca gtaatcggcc ctcaggggtt      180

tctaatcgct tctctggctc caagtctggc aacacggcct ccctgaccat ctctgggctc      240

caggctgacg acgaggctga ttattactgc agctcatata caagtttcac tcccgtggta      300

ttcggcggag ggaccaaggt gaccgtccta                                       330


<210> 1114
<211> 110
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region"

<400> 1114
Gln Pro Val Leu Thr Gln Pro Ala Ser Val Ser Ala Ser Pro Gly Gln 
1               5                   10                  15      


Ser Ile Thr Ile Ser Cys Thr Gly Thr Ser Ser Asp Val Gly Gly Tyr 
            20                  25                  30          


Asn Tyr Val Ser Trp Tyr Gln Gln His Pro Gly Lys Ala Pro Lys Leu 
        35                  40                  45              


Ile Val Tyr Glu Val Ser Asn Arg Pro Ser Gly Val Ser Asn Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Asn Thr Ala Ser Leu Thr Ile Ser Gly Leu 
65                  70                  75                  80  


Gln Ala Asp Asp Glu Ala Asp Tyr Tyr Cys Ser Ser Tyr Thr Ser Phe 
                85                  90                  95      


Thr Pro Val Val Phe Gly Gly Gly Thr Lys Val Thr Val Leu 
            100                 105                 110 


<210> 1115
<211> 14
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L1"

<400> 1115
Thr Gly Thr Ser Ser Asp Val Gly Gly Tyr Asn Tyr Val Ser 
1               5                   10                  


<210> 1116
<211> 42
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L1"

<400> 1116
actggaacca gcagtgacgt tggtggttat aattatgtct cc                          42


<210> 1117
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L2"

<400> 1117
Glu Val Ser Asn Arg Pro Ser 
1               5           


<210> 1118
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L2"

<400> 1118
gaggtcagta atcggccctc a                                                 21


<210> 1119
<211> 10
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L3"

<400> 1119
Ser Ser Tyr Thr Ser Phe Thr Pro Val Val 
1               5                   10  


<210> 1120
<211> 30
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L3"

<400> 1120
agctcatata caagtttcac tcccgtggta                                        30


<210> 1121
<211> 378
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region"

<400> 1121
gaggtgcagc tggtggagtc tgggggaggc ttggttcagc ctggggggtc cctgagactc       60

tcctgtgcag cctctggatt cacttttagc gactttgcca tgagctgggt ccgccaggct      120

ccagggaagg ggctggagtg ggtctcactt attaaaagta gtgattatgc atactatgca      180

gactccgtga ggggccggtt caccatctcc agagacaatt ccaagaacac cctgtatctg      240

cgaatgaaca gcctgagagc cgacgacacg gccgtatatt actgtgcgaa agacgccgat      300

ttttggagtg gtgattccta caatggaggg tacaactttg actcctgggg ccagggaacc      360

ctggtcaccg tctcctca                                                    378


<210> 1122
<211> 126
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region"

<400> 1122
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp Phe 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Leu Ile Lys Ser Ser Asp Tyr Ala Tyr Tyr Ala Asp Ser Val Arg 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu 
65                  70                  75                  80  


Arg Met Asn Ser Leu Arg Ala Asp Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Lys Asp Ala Asp Phe Trp Ser Gly Asp Ser Tyr Asn Gly Gly Tyr Asn 
            100                 105                 110         


Phe Asp Ser Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125     


<210> 1123
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H1"

<400> 1123
Phe Thr Phe Ser Asp Phe Ala Met Ser 
1               5                   


<210> 1124
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H1"

<400> 1124
ttcactttta gcgactttgc catgagc                                           27


<210> 1125
<211> 16
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H2"

<400> 1125
Leu Ile Lys Ser Ser Asp Tyr Ala Tyr Tyr Ala Asp Ser Val Arg Gly 
1               5                   10                  15      


<210> 1126
<211> 48
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H2"

<400> 1126
cttattaaaa gtagtgatta tgcatactat gcagactccg tgaggggc                    48


<210> 1127
<211> 20
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H3"

<400> 1127
Ala Lys Asp Ala Asp Phe Trp Ser Gly Asp Ser Tyr Asn Gly Gly Tyr 
1               5                   10                  15      


Asn Phe Asp Ser 
            20  


<210> 1128
<211> 60
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H3"

<400> 1128
gcgaaagacg ccgatttttg gagtggtgat tcctacaatg gagggtacaa ctttgactcc       60


<210> 1129
<211> 324
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region"

<400> 1129
gatattgtgc tgacccagtc tccagccacc ctgtctgtat ctccagggga aagagccacc       60

ctctcctgca gggccagtca gagtgttggc accaacttgg cctggtacca gcaaaaacct      120

ggccaggctc cccggctcct catctttggt gcctcaacca gggccactgg tatcccagcc      180

aggttcagtg gcagtgggtc tgggacagag ttcactctca ccatcagcag cctgcagtct      240

gaagattttg cagtttatta ctgtcagcag tataataagt ggcctccgct cactttcggc      300

ggagggacca aagtggatat caaa                                             324


<210> 1130
<211> 108
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region"

<400> 1130
Asp Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Val Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Gly Thr Asn 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 
        35                  40                  45              


Phe Gly Ala Ser Thr Arg Ala Thr Gly Ile Pro Ala Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Ser 
65                  70                  75                  80  


Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Asn Lys Trp Pro Pro 
                85                  90                  95      


Leu Thr Phe Gly Gly Gly Thr Lys Val Asp Ile Lys 
            100                 105             


<210> 1131
<211> 11
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L1"

<400> 1131
Arg Ala Ser Gln Ser Val Gly Thr Asn Leu Ala 
1               5                   10      


<210> 1132
<211> 33
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L1"

<400> 1132
agggccagtc agagtgttgg caccaacttg gcc                                    33


<210> 1133
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L2"

<400> 1133
Gly Ala Ser Thr Arg Ala Thr 
1               5           


<210> 1134
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L2"

<400> 1134
ggtgcctcaa ccagggccac t                                                 21


<210> 1135
<211> 10
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L3"

<400> 1135
Gln Gln Tyr Asn Lys Trp Pro Pro Leu Thr 
1               5                   10  


<210> 1136
<211> 30
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L3"

<400> 1136
cagcagtata ataagtggcc tccgctcact                                        30


<210> 1137
<211> 366
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region"

<400> 1137
caggtccagc ttgtgcagtc tgggggaggc ttggtcaagc ctggagggtc cctgagactc       60

tcctgtgcag cctctggatt catcttcagt gactactaca tggtctggat ccgtcaggct      120

ccagggaagg ggctggagtg ggtttcatac attagtagta gcagcagata cataaactac      180

gcagactctg tgaagggccg attcaccatc tccagagaca acgccaagaa ctcactgttt      240

ctgcaaatga acaccgtgag agccgaggac acggctgtgt attactgtgc gcaaggctgg      300

tattccgatt tttggagtgg tcccattagg atttggggcc agggaaccct ggtcaccgtc      360

tcctca                                                                 366


<210> 1138
<211> 122
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region"

<400> 1138
Gln Val Gln Leu Val Gln Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ile Phe Ser Asp Tyr 
            20                  25                  30          


Tyr Met Val Trp Ile Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Tyr Ile Ser Ser Ser Ser Arg Tyr Ile Asn Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Phe 
65                  70                  75                  80  


Leu Gln Met Asn Thr Val Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Gln Gly Trp Tyr Ser Asp Phe Trp Ser Gly Pro Ile Arg Ile Trp 
            100                 105                 110         


Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120         


<210> 1139
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H1"

<400> 1139
Phe Ile Phe Ser Asp Tyr Tyr Met Val 
1               5                   


<210> 1140
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H1"

<400> 1140
ttcatcttca gtgactacta catggtc                                           27


<210> 1141
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H2"

<400> 1141
Tyr Ile Ser Ser Ser Ser Arg Tyr Ile Asn Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210> 1142
<211> 51
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H2"

<400> 1142
tacattagta gtagcagcag atacataaac tacgcagact ctgtgaaggg c                51


<210> 1143
<211> 15
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H3"

<400> 1143
Ala Gln Gly Trp Tyr Ser Asp Phe Trp Ser Gly Pro Ile Arg Ile 
1               5                   10                  15  


<210> 1144
<211> 45
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H3"

<400> 1144
gcgcaaggct ggtattccga tttttggagt ggtcccatta ggatt                       45


<210> 1145
<211> 321
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region"

<400> 1145
gacatccagt tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga cagagtcacc       60

atcacttgcc aggcgagtca ggacattagt aactctttaa attggtttca gcagaaacct      120

gggaaagccc ctaagctcct gatcttcgat gcatacaatc tggaaacagg ggtcccatca      180

aggttcagtg gaagtggatc tgggacagat tttaccctca ccatcagcag cctgcagcct      240

gaagatattg caacatatta ctgtcagcag aatgataatc tcgttctcac tttcggcgga      300

gggaccaagc tggagatcaa a                                                321


<210> 1146
<211> 107
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region"

<400> 1146
Asp Ile Gln Leu Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Gln Ala Ser Gln Asp Ile Ser Asn Ser 
            20                  25                  30          


Leu Asn Trp Phe Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Phe Asp Ala Tyr Asn Leu Glu Thr Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Ile Ala Thr Tyr Tyr Cys Gln Gln Asn Asp Asn Leu Val Leu 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210> 1147
<211> 11
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L1"

<400> 1147
Gln Ala Ser Gln Asp Ile Ser Asn Ser Leu Asn 
1               5                   10      


<210> 1148
<211> 33
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L1"

<400> 1148
caggcgagtc aggacattag taactcttta aat                                    33


<210> 1149
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L2"

<400> 1149
Asp Ala Tyr Asn Leu Glu Thr 
1               5           


<210> 1150
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L2"

<400> 1150
gatgcataca atctggaaac a                                                 21


<210> 1151
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L3"

<400> 1151
Gln Gln Asn Asp Asn Leu Val Leu Thr 
1               5                   


<210> 1152
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L3"

<400> 1152
cagcagaatg ataatctcgt tctcact                                           27


<210> 1153
<211> 378
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region"

<400> 1153
caggtgcagc tggtggagtc tgggggaggc ttggtacagc ctggcaggtc cctgagactc       60

tcctgtgcag cctctggatt cacgtttgat aattacccca tgcactggat ccggcaagct      120

ccagggaagg gcctggagtg ggtctcaggt attagttggc atagtggaag cataggctat      180

gcggactctg tgaagggccg attcaccatc tccagagaca acgccaagaa ctccctgtat      240

ctgcaaatga acagtctgag aactgaggac acggccttgt attactgtgc aaaagacgcc      300

cattactttg ataatagcgg tcactactac tacggtctgg acgtctgggg ccaagggacc      360

acggtcaccg tctcctca                                                    378


<210> 1154
<211> 126
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region"

<400> 1154
Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Asn Tyr 
            20                  25                  30          


Pro Met His Trp Ile Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Gly Ile Ser Trp His Ser Gly Ser Ile Gly Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Thr Glu Asp Thr Ala Leu Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Asp Ala His Tyr Phe Asp Asn Ser Gly His Tyr Tyr Tyr Gly 
            100                 105                 110         


Leu Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120                 125     


<210> 1155
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H1"

<400> 1155
Phe Thr Phe Asp Asn Tyr Pro Met His 
1               5                   


<210> 1156
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H1"

<400> 1156
ttcacgtttg ataattaccc catgcac                                           27


<210> 1157
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H2"

<400> 1157
Gly Ile Ser Trp His Ser Gly Ser Ile Gly Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210> 1158
<211> 51
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H2"

<400> 1158
ggtattagtt ggcatagtgg aagcataggc tatgcggact ctgtgaaggg c                51


<210> 1159
<211> 19
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H3"

<400> 1159
Ala Lys Asp Ala His Tyr Phe Asp Asn Ser Gly His Tyr Tyr Tyr Gly 
1               5                   10                  15      


Leu Asp Val 
            


<210> 1160
<211> 57
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H3"

<400> 1160
gcaaaagacg cccattactt tgataatagc ggtcactact actacggtct ggacgtc          57


<210> 1161
<211> 321
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region"

<400> 1161
gaaattgtgt tgacacagtc tccagccacc ctgtctgtgt ctccagggga aagagccacc       60

ctctcctgca gggccagtca gaatattatc aacaacttag cctggtacca gcagaaacct      120

ggccaggctc ccaggctcct catctctggt gcatccacca gggccactgg tatcccagcc      180

aggttcagtg gcagtgggtc tgggacagag ttcactctca ccatcaccag cctgcagtct      240

gaagattttg cagtttatta ctgtcagcag tataataact ggccgctcac tttcggcgga      300

gggaccaaag tggatatcaa a                                                321


<210> 1162
<211> 107
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region"

<400> 1162
Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Val Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Asn Ile Ile Asn Asn 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 
        35                  40                  45              


Ser Gly Ala Ser Thr Arg Ala Thr Gly Ile Pro Ala Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Thr Ser Leu Gln Ser 
65                  70                  75                  80  


Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Asn Asn Trp Pro Leu 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Val Asp Ile Lys 
            100                 105         


<210> 1163
<211> 11
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L1"

<400> 1163
Arg Ala Ser Gln Asn Ile Ile Asn Asn Leu Ala 
1               5                   10      


<210> 1164
<211> 33
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L1"

<400> 1164
agggccagtc agaatattat caacaactta gcc                                    33


<210> 1165
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L2"

<400> 1165
Gly Ala Ser Thr Arg Ala Thr 
1               5           


<210> 1166
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L2"

<400> 1166
ggtgcatcca ccagggccac t                                                 21


<210> 1167
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L3"

<400> 1167
Gln Gln Tyr Asn Asn Trp Pro Leu Thr 
1               5                   


<210> 1168
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L3"

<400> 1168
cagcagtata ataactggcc gctcact                                           27


<210> 1169
<211> 387
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region"

<400> 1169
caggtccagc tggtgcagtc tgggggaggc ttggtacagc cagggcggtc cctgagactc       60

tcctgtacag cctctggatt cagcttcagt gattatggag tgacctgggt ccgccaggct      120

ccagggaagg ggctggagtg gataggtttc gtcagaacca agggttatgg agggacaaca      180

gagtacgccg cgtctgtgag aggcagattc accatctcaa gagatgactc caaaagcgtc      240

gcctatctac aattgaacag cctgaaagtc gaggatacag ccgtctatta ctgttctggg      300

gcatcacggg gcttttggag tgggccaacc tactactact ttggtatgga cgtctggggc      360

catgggacca cggtcactgt ctcctca                                          387


<210> 1170
<211> 129
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region"

<400> 1170
Gln Val Gln Leu Val Gln Ser Gly Gly Gly Leu Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Thr Ala Ser Gly Phe Ser Phe Ser Asp Tyr 
            20                  25                  30          


Gly Val Thr Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Phe Val Arg Thr Lys Gly Tyr Gly Gly Thr Thr Glu Tyr Ala Ala 
    50                  55                  60                  


Ser Val Arg Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Ser Val 
65                  70                  75                  80  


Ala Tyr Leu Gln Leu Asn Ser Leu Lys Val Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Ser Gly Ala Ser Arg Gly Phe Trp Ser Gly Pro Thr Tyr Tyr 
            100                 105                 110         


Tyr Phe Gly Met Asp Val Trp Gly His Gly Thr Thr Val Thr Val Ser 
        115                 120                 125             


Ser 
    


<210> 1171
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H1"

<400> 1171
Phe Ser Phe Ser Asp Tyr Gly Val Thr 
1               5                   


<210> 1172
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H1"

<400> 1172
ttcagcttca gtgattatgg agtgacc                                           27


<210> 1173
<211> 19
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H2"

<400> 1173
Phe Val Arg Thr Lys Gly Tyr Gly Gly Thr Thr Glu Tyr Ala Ala Ser 
1               5                   10                  15      


Val Arg Gly 
            


<210> 1174
<211> 57
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H2"

<400> 1174
ttcgtcagaa ccaagggtta tggagggaca acagagtacg ccgcgtctgt gagaggc          57


<210> 1175
<211> 20
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H3"

<400> 1175
Ser Gly Ala Ser Arg Gly Phe Trp Ser Gly Pro Thr Tyr Tyr Tyr Phe 
1               5                   10                  15      


Gly Met Asp Val 
            20  


<210> 1176
<211> 60
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H3"

<400> 1176
tctggggcat cacggggctt ttggagtggg ccaacctact actactttgg tatggacgtc       60


<210> 1177
<211> 330
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region"

<400> 1177
gaaattgtgt tgacacagtc tccactctcc ctggccgtca cccctggaga gccggcctcc       60

atctcctgca ggtctagtca gagcctcctg catggtaatg gatacaacta cttggattgg      120

tacctgcaga agccagggca gtctccacaa ctcctgatct tttggggttc ttatcgggcc      180

tccggggccc ctgacaggtt cagtgccagt ggatcaggct cagagtttac actgaaaatc      240

agaagagtgg aggctgagga tgtgggggtt tattactgca tgcaacctct acaaacaact      300

tttggccagg ggaccaaagt ggatatcaaa                                       330


<210> 1178
<211> 110
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region"

<400> 1178
Glu Ile Val Leu Thr Gln Ser Pro Leu Ser Leu Ala Val Thr Pro Gly 
1               5                   10                  15      


Glu Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Leu His Gly 
            20                  25                  30          


Asn Gly Tyr Asn Tyr Leu Asp Trp Tyr Leu Gln Lys Pro Gly Gln Ser 
        35                  40                  45              


Pro Gln Leu Leu Ile Phe Trp Gly Ser Tyr Arg Ala Ser Gly Ala Pro 
    50                  55                  60                  


Asp Arg Phe Ser Ala Ser Gly Ser Gly Ser Glu Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Arg Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Met Gln Pro 
                85                  90                  95      


Leu Gln Thr Thr Phe Gly Gln Gly Thr Lys Val Asp Ile Lys 
            100                 105                 110 


<210> 1179
<211> 16
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L1"

<400> 1179
Arg Ser Ser Gln Ser Leu Leu His Gly Asn Gly Tyr Asn Tyr Leu Asp 
1               5                   10                  15      


<210> 1180
<211> 48
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L1"

<400> 1180
aggtctagtc agagcctcct gcatggtaat ggatacaact acttggat                    48


<210> 1181
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L2"

<400> 1181
Trp Gly Ser Tyr Arg Ala Ser 
1               5           


<210> 1182
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L2"

<400> 1182
tggggttctt atcgggcctc c                                                 21


<210> 1183
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L3"

<400> 1183
Met Gln Pro Leu Gln Thr Thr 
1               5           


<210> 1184
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L3"

<400> 1184
atgcaacctc tacaaacaac t                                                 21


<210> 1185
<211> 360
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region"

<400> 1185
caggtccagc tggtgcagtc tggagcagag gtgaaaaagc ccggggagtc tctaaagatc       60

tcctgtaagg gttctggata cacctttaga atgtattgga tcggctgggc gcgcctgctg      120

cccgggaaag gcctggagtg gataggaatc atctatcctg gtgactctga taccaggtac      180

aacccgtccc tccaaggcca ggtcaccatg tcagtcgaca agtccatcaa caccgcctac      240

ctccagtggg gaagcctgaa ggcctcggac agcgccattt attactgtgc gagactgaga      300

ttacatcccc agagtggaat ggacgtctgg ggccaaggga ccctggtcac cgtctcctca      360


<210> 1186
<211> 120
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region"

<400> 1186
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu 
1               5                   10                  15      


Ser Leu Lys Ile Ser Cys Lys Gly Ser Gly Tyr Thr Phe Arg Met Tyr 
            20                  25                  30          


Trp Ile Gly Trp Ala Arg Leu Leu Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Ile Ile Tyr Pro Gly Asp Ser Asp Thr Arg Tyr Asn Pro Ser Leu 
    50                  55                  60                  


Gln Gly Gln Val Thr Met Ser Val Asp Lys Ser Ile Asn Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Trp Gly Ser Leu Lys Ala Ser Asp Ser Ala Ile Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Leu Arg Leu His Pro Gln Ser Gly Met Asp Val Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser 
        115                 120 


<210> 1187
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H1"

<400> 1187
Tyr Thr Phe Arg Met Tyr Trp Ile Gly 
1               5                   


<210> 1188
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H1"

<400> 1188
tacaccttta gaatgtattg gatcggc                                           27


<210> 1189
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H2"

<400> 1189
Ile Ile Tyr Pro Gly Asp Ser Asp Thr Arg Tyr Asn Pro Ser Leu Gln 
1               5                   10                  15      


Gly 
    


<210> 1190
<211> 51
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H2"

<400> 1190
atcatctatc ctggtgactc tgataccagg tacaacccgt ccctccaagg c                51


<210> 1191
<211> 13
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H3"

<400> 1191
Ala Arg Leu Arg Leu His Pro Gln Ser Gly Met Asp Val 
1               5                   10              


<210> 1192
<211> 39
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H3"

<400> 1192
gcgagactga gattacatcc ccagagtgga atggacgtc                              39


<210> 1193
<211> 330
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region"

<400> 1193
aattttatgc tgactcagcc ccactctgtg tcggagtctc cggggaagac ggtagttatc       60

tcctgcaccc gcagcagtgg cagcattgcc ggctactatg tgcagtggta ccaacatcgc      120

ccgggcagtt cccccactac tgtgatatat gaggatgacc aaagaccctc tggggtccct      180

gatcggttct ctgggtccgt cgacagctcc tccaactctg cctccctcac catctctgga      240

ctgaagactg aggacgaggc tgactactat tgtcagtcct atgataacgc catttgggtg      300

ttcggcggag ggaccaagct caccgtccta                                       330


<210> 1194
<211> 110
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region"

<400> 1194
Asn Phe Met Leu Thr Gln Pro His Ser Val Ser Glu Ser Pro Gly Lys 
1               5                   10                  15      


Thr Val Val Ile Ser Cys Thr Arg Ser Ser Gly Ser Ile Ala Gly Tyr 
            20                  25                  30          


Tyr Val Gln Trp Tyr Gln His Arg Pro Gly Ser Ser Pro Thr Thr Val 
        35                  40                  45              


Ile Tyr Glu Asp Asp Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Val Asp Ser Ser Ser Asn Ser Ala Ser Leu Thr Ile Ser Gly 
65                  70                  75                  80  


Leu Lys Thr Glu Asp Glu Ala Asp Tyr Tyr Cys Gln Ser Tyr Asp Asn 
                85                  90                  95      


Ala Ile Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 110 


<210> 1195
<211> 13
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L1"

<400> 1195
Thr Arg Ser Ser Gly Ser Ile Ala Gly Tyr Tyr Val Gln 
1               5                   10              


<210> 1196
<211> 39
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L1"

<400> 1196
acccgcagca gtggcagcat tgccggctac tatgtgcag                              39


<210> 1197
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L2"

<400> 1197
Glu Asp Asp Gln Arg Pro Ser 
1               5           


<210> 1198
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L2"

<400> 1198
gaggatgacc aaagaccctc t                                                 21


<210> 1199
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L3"

<400> 1199
Gln Ser Tyr Asp Asn Ala Ile Trp Val 
1               5                   


<210> 1200
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L3"

<400> 1200
cagtcctatg ataacgccat ttgggtg                                           27


<210> 1201
<211> 366
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region"

<400> 1201
caggtgcagc ttgtgcagtc tggggctgag gtgaagaagc ctgggtcctc ggtgaaggtc       60

tcctgcaagg cttctggagg caccttcagc agctatgcta tcagctgggt gcgacaggcc      120

cctggacaag ggcttgagtg gatgggaggg atcatcccta tctttggtac agtaaactac      180

gcacagaagt tccagggcag agtcacgatt accgcggacg aatccacgag cacagcctac      240

atggagctga gcagtctgag atctgaggac acggccgtgt attactgtgc gagagatcgt      300

tcggtgaccc ctcgctacta cggtatggac gtctggggcc aagggaccac ggtcaccgtc      360

tcctca                                                                 366


<210> 1202
<211> 122
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region"

<400> 1202
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Gly Ile Ile Pro Ile Phe Gly Thr Val Asn Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Arg Ser Val Thr Pro Arg Tyr Tyr Gly Met Asp Val Trp 
            100                 105                 110         


Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120         


<210> 1203
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H1"

<400> 1203
Gly Thr Phe Ser Ser Tyr Ala Ile Ser 
1               5                   


<210> 1204
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H1"

<400> 1204
ggcaccttca gcagctatgc tatcagc                                           27


<210> 1205
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H2"

<400> 1205
Gly Ile Ile Pro Ile Phe Gly Thr Val Asn Tyr Ala Gln Lys Phe Gln 
1               5                   10                  15      


Gly 
    


<210> 1206
<211> 51
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H2"

<400> 1206
gggatcatcc ctatctttgg tacagtaaac tacgcacaga agttccaggg c                51


<210> 1207
<211> 15
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H3"

<400> 1207
Ala Arg Asp Arg Ser Val Thr Pro Arg Tyr Tyr Gly Met Asp Val 
1               5                   10                  15  


<210> 1208
<211> 45
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H3"

<400> 1208
gcgagagatc gttcggtgac ccctcgctac tacggtatgg acgtc                       45


<210> 1209
<211> 324
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region"

<400> 1209
gaaattgtga tgacacagtc tccagccacc ctgtctttgt ctccagggga aagagccacc       60

ctctcctgca gggccagtca gagtgttagc agctacttag cctggtacca acagaaacct      120

ggccaggctc ccaggctcct catctatgat gcatccaaca gggccactgg catcccagcc      180

aggttcagtg gcagtgggtc tgggacagac ttcactctca ccatcagcag cctagagcct      240

gaagattttg cagtttatta ctgtcagcac cgtagcaact ggcctccact cactttcggc      300

cctgggacca agctggagat caaa                                             324


<210> 1210
<211> 108
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region"

<400> 1210
Glu Ile Val Met Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Tyr 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 
        35                  40                  45              


Tyr Asp Ala Ser Asn Arg Ala Thr Gly Ile Pro Ala Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Val Tyr Tyr Cys Gln His Arg Ser Asn Trp Pro Pro 
                85                  90                  95      


Leu Thr Phe Gly Pro Gly Thr Lys Leu Glu Ile Lys 
            100                 105             


<210> 1211
<211> 11
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L1"

<400> 1211
Arg Ala Ser Gln Ser Val Ser Ser Tyr Leu Ala 
1               5                   10      


<210> 1212
<211> 33
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L1"

<400> 1212
agggccagtc agagtgttag cagctactta gcc                                    33


<210> 1213
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L2"

<400> 1213
Asp Ala Ser Asn Arg Ala Thr 
1               5           


<210> 1214
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L2"

<400> 1214
gatgcatcca acagggccac t                                                 21


<210> 1215
<211> 10
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L3"

<400> 1215
Gln His Arg Ser Asn Trp Pro Pro Leu Thr 
1               5                   10  


<210> 1216
<211> 30
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L3"

<400> 1216
cagcaccgta gcaactggcc tccactcact                                        30


<210> 1217
<211> 357
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region"

<400> 1217
gaggtgcagc tgttggagtc tgggggaggc ctggtcaagc ctggggggtc cctgagactc       60

tcctgtgcag cctcgggatt caccatcagt ggttataaca tgttctgggt ccgccagcct      120

ccggggaagg ggctggagtg ggtctcatcc attactgctg gtagtagtta tttaaactat      180

gcagactcag tgaagggccg tttcatcgtc tccagagaca acgccaagaa ttcactgtat      240

ctgcaaatga acagcctgag agccgaggac acggctgttt atttctgtgc gagagcacct      300

cttttacccg ctatgatgga cctctggggc caagggacca cggtcaccgt ctcctca         357


<210> 1218
<211> 119
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region"

<400> 1218
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Ile Ser Gly Tyr 
            20                  25                  30          


Asn Met Phe Trp Val Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ser Ile Thr Ala Gly Ser Ser Tyr Leu Asn Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Ile Val Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Phe Cys 
                85                  90                  95      


Ala Arg Ala Pro Leu Leu Pro Ala Met Met Asp Leu Trp Gly Gln Gly 
            100                 105                 110         


Thr Thr Val Thr Val Ser Ser 
        115                 


<210> 1219
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H1"

<400> 1219
Phe Thr Ile Ser Gly Tyr Asn Met Phe 
1               5                   


<210> 1220
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H1"

<400> 1220
ttcaccatca gtggttataa catgttc                                           27


<210> 1221
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H2"

<400> 1221
Ser Ile Thr Ala Gly Ser Ser Tyr Leu Asn Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210> 1222
<211> 51
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H2"

<400> 1222
tccattactg ctggtagtag ttatttaaac tatgcagact cagtgaaggg c                51


<210> 1223
<211> 12
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H3"

<400> 1223
Ala Arg Ala Pro Leu Leu Pro Ala Met Met Asp Leu 
1               5                   10          


<210> 1224
<211> 36
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H3"

<400> 1224
gcgagagcac ctcttttacc cgctatgatg gacctc                                 36


<210> 1225
<211> 333
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region"

<400> 1225
cagtctgtgc tgacgcagcc gccctcagtg tctggggccc cagggcagag ggtcaccatc       60

tcctgcactg ggagcagctc caacatcggg gcaggttatg atgtacactg gtaccagcaa      120

cttccaggaa cagcccccaa actcctcatc tatactaaca acaatcggcc ctcaggggtc      180

cctgaccgat tctctggctc caagtctggc acctcagcct ccctggccat cactgggctc      240

caggctgagg atgaggctga ctattactgc cagtcctatg acagaagcct gaatggttat      300

gtcttcggaa ctgggaccaa ggtcaccgtc cta                                   333


<210> 1226
<211> 111
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region"

<400> 1226
Gln Ser Val Leu Thr Gln Pro Pro Ser Val Ser Gly Ala Pro Gly Gln 
1               5                   10                  15      


Arg Val Thr Ile Ser Cys Thr Gly Ser Ser Ser Asn Ile Gly Ala Gly 
            20                  25                  30          


Tyr Asp Val His Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu 
        35                  40                  45              


Leu Ile Tyr Thr Asn Asn Asn Arg Pro Ser Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Thr Gly Leu 
65                  70                  75                  80  


Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Gln Ser Tyr Asp Arg Ser 
                85                  90                  95      


Leu Asn Gly Tyr Val Phe Gly Thr Gly Thr Lys Val Thr Val Leu 
            100                 105                 110     


<210> 1227
<211> 14
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L1"

<400> 1227
Thr Gly Ser Ser Ser Asn Ile Gly Ala Gly Tyr Asp Val His 
1               5                   10                  


<210> 1228
<211> 42
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L1"

<400> 1228
actgggagca gctccaacat cggggcaggt tatgatgtac ac                          42


<210> 1229
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L2"

<400> 1229
Thr Asn Asn Asn Arg Pro Ser 
1               5           


<210> 1230
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L2"

<400> 1230
actaacaaca atcggccctc a                                                 21


<210> 1231
<211> 11
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L3"

<400> 1231
Gln Ser Tyr Asp Arg Ser Leu Asn Gly Tyr Val 
1               5                   10      


<210> 1232
<211> 33
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L3"

<400> 1232
cagtcctatg acagaagcct gaatggttat gtc                                    33


<210> 1233
<211> 366
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region"

<400> 1233
gaggtgcagc tggtggagtc tggggctgag gtgaagaagc ctgggtcctc ggtgaaggtc       60

tcctgcaagg cttctgcaga caccttcagc agttatgcta tcagctgggt gcggcaggcc      120

cctggacaag ggcttgagtg gatgggaggg atcctcccta tccttggtac agcaaactcc      180

gcacagaagt tccggggcag agtcacgttt accgcggacg aatccacgac cacagcctac      240

atggaactga gcagcctgag atctgaggac acggccgtct attactgcgc gaggcttgct      300

ggaccacggt ggccggggta cggtatggac gtctggggcc aagggaccct ggtcaccgtc      360

tcctca                                                                 366


<210> 1234
<211> 122
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region"

<400> 1234
Glu Val Gln Leu Val Glu Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Ala Asp Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Gly Ile Leu Pro Ile Leu Gly Thr Ala Asn Ser Ala Gln Lys Phe 
    50                  55                  60                  


Arg Gly Arg Val Thr Phe Thr Ala Asp Glu Ser Thr Thr Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Leu Ala Gly Pro Arg Trp Pro Gly Tyr Gly Met Asp Val Trp 
            100                 105                 110         


Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120         


<210> 1235
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H1"

<400> 1235
Asp Thr Phe Ser Ser Tyr Ala Ile Ser 
1               5                   


<210> 1236
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H1"

<400> 1236
gacaccttca gcagttatgc tatcagc                                           27


<210> 1237
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H2"

<400> 1237
Gly Ile Leu Pro Ile Leu Gly Thr Ala Asn Ser Ala Gln Lys Phe Arg 
1               5                   10                  15      


Gly 
    


<210> 1238
<211> 51
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H2"

<400> 1238
gggatcctcc ctatccttgg tacagcaaac tccgcacaga agttccgggg c                51


<210> 1239
<211> 15
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H3"

<400> 1239
Ala Arg Leu Ala Gly Pro Arg Trp Pro Gly Tyr Gly Met Asp Val 
1               5                   10                  15  


<210> 1240
<211> 45
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H3"

<400> 1240
gcgaggcttg ctggaccacg gtggccgggg tacggtatgg acgtc                       45


<210> 1241
<211> 321
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region"

<400> 1241
gacatccagt tgacccagtc tccatccttc ctgtctgctt ctgtaggaga cagagtcacc       60

atcacttgcc gggccagtca gggcattagc agttatttag cctggtatca acagaaacca      120

gggaaagccc ctaaactcct gatctatgct gcatccactt tgcaaagtgg ggtcccatca      180

aggttcagcg gcagtggatc tgggacagaa ttcactctca caatcagcag cctgcagcct      240

gaagattttg caacttatta ctgtcagcag cttaacagtt tccccctcac cttcggcgga      300

gggaccaagg tggaaatcaa a                                                321


<210> 1242
<211> 107
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region"

<400> 1242
Asp Ile Gln Leu Thr Gln Ser Pro Ser Phe Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Ser Ser Tyr 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Thr Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Leu Asn Ser Phe Pro Leu 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210> 1243
<211> 11
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L1"

<400> 1243
Arg Ala Ser Gln Gly Ile Ser Ser Tyr Leu Ala 
1               5                   10      


<210> 1244
<211> 33
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L1"

<400> 1244
cgggccagtc agggcattag cagttattta gcc                                    33


<210> 1245
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L2"

<400> 1245
Ala Ala Ser Thr Leu Gln Ser 
1               5           


<210> 1246
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L2"

<400> 1246
gctgcatcca ctttgcaaag t                                                 21


<210> 1247
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L3"

<400> 1247
Gln Gln Leu Asn Ser Phe Pro Leu Thr 
1               5                   


<210> 1248
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L3"

<400> 1248
cagcagctta acagtttccc cctcacc                                           27


<210> 1249
<211> 354
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region"

<400> 1249
caggtccagc tggtgcagtc tggggctgag gtgacgaagc ctggggcctc agtgagggtc       60

tcctgcaaat tttccgcata caccctctct gcattatcca ttcactgggt gcgacaggct      120

cctggaaaag gccttgagtg gatgggagct tttgatcctg aggatggtga gccaatctac      180

tcacagcatt tccagggcag agtcaccatg accgaggaca cttctacaca gacagcctac      240

atggagctga acagcctgag atctgaggac acggccgttt attactgttc atccgtagga      300

ccagcggggt ggttcgaccc ctggggccag ggaaccctgg tcaccgtctc ctca            354


<210> 1250
<211> 118
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region"

<400> 1250
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Thr Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Arg Val Ser Cys Lys Phe Ser Ala Tyr Thr Leu Ser Ala Leu 
            20                  25                  30          


Ser Ile His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Ala Phe Asp Pro Glu Asp Gly Glu Pro Ile Tyr Ser Gln His Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Met Thr Glu Asp Thr Ser Thr Gln Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Asn Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ser Ser Val Gly Pro Ala Gly Trp Phe Asp Pro Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser 
        115             


<210> 1251
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H1"

<400> 1251
Tyr Thr Leu Ser Ala Leu Ser Ile His 
1               5                   


<210> 1252
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H1"

<400> 1252
tacaccctct ctgcattatc cattcac                                           27


<210> 1253
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H2"

<400> 1253
Ala Phe Asp Pro Glu Asp Gly Glu Pro Ile Tyr Ser Gln His Phe Gln 
1               5                   10                  15      


Gly 
    


<210> 1254
<211> 51
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H2"

<400> 1254
gcttttgatc ctgaggatgg tgagccaatc tactcacagc atttccaggg c                51


<210> 1255
<211> 11
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H3"

<400> 1255
Ser Ser Val Gly Pro Ala Gly Trp Phe Asp Pro 
1               5                   10      


<210> 1256
<211> 33
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H3"

<400> 1256
tcatccgtag gaccagcggg gtggttcgac ccc                                    33


<210> 1257
<211> 321
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region"

<400> 1257
gacatccggt tgacccagtc tccatcctcc ctgtctgcat ctgtgggaga cagagtcagc       60

atcacttgcc gggcaagtca gagcattagc agctatttac attggtatca acaaaaacca      120

gggaaagccc ctaagctcct gatctatgct gcatccagtt tgcaaagtgg ggtcccatca      180

aggttcagtg gcagtggatc tgggtcagat ttcactctca ccatcagcag tctgcaacct      240

gaagattttg caacttacta ctgtcaccag agttacattc ccccattcac tttcggccct      300

gggaccaagc tggagatcaa a                                                321


<210> 1258
<211> 107
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region"

<400> 1258
Asp Ile Arg Leu Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Ser Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Tyr 
            20                  25                  30          


Leu His Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Ser Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys His Gln Ser Tyr Ile Pro Pro Phe 
                85                  90                  95      


Thr Phe Gly Pro Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210> 1259
<211> 11
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L1"

<400> 1259
Arg Ala Ser Gln Ser Ile Ser Ser Tyr Leu His 
1               5                   10      


<210> 1260
<211> 33
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L1"

<400> 1260
cgggcaagtc agagcattag cagctattta cat                                    33


<210> 1261
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L2"

<400> 1261
Ala Ala Ser Ser Leu Gln Ser 
1               5           


<210> 1262
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L2"

<400> 1262
gctgcatcca gtttgcaaag t                                                 21


<210> 1263
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L3"

<400> 1263
His Gln Ser Tyr Ile Pro Pro Phe Thr 
1               5                   


<210> 1264
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L3"

<400> 1264
caccagagtt acattccccc attcact                                           27


<210> 1265
<211> 360
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region"

<400> 1265
gaggtgcagc tggtggagtc tgggggaggc ctggtcaagc ctggggggtc cctgagactc       60

tcctgtgcag cctctggatt caccatcact agctatggca tgaactgggt ccgccaggct      120

ccaggaaagg ggctggagtg ggtctcatcc attagtagta gtagtagttt catacactat      180

ggagactcag tgaagggtcg attcaccatc tccagagaca acgccaagaa ctcactgtat      240

ctgcaaatga acagcctgag agccggggac acggctgtat actactgtgt gagagactcg      300

ggccaccagg actaccgcgg ggactactgg ggccagggaa ccctggtcac cgtctcctca      360


<210> 1266
<211> 120
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region"

<400> 1266
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Ile Thr Ser Tyr 
            20                  25                  30          


Gly Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ser Ile Ser Ser Ser Ser Ser Phe Ile His Tyr Gly Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Gly Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Val Arg Asp Ser Gly His Gln Asp Tyr Arg Gly Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser 
        115                 120 


<210> 1267
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H1"

<400> 1267
Phe Thr Ile Thr Ser Tyr Gly Met Asn 
1               5                   


<210> 1268
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H1"

<400> 1268
ttcaccatca ctagctatgg catgaac                                           27


<210> 1269
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H2"

<400> 1269
Ser Ile Ser Ser Ser Ser Ser Phe Ile His Tyr Gly Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210> 1270
<211> 51
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H2"

<400> 1270
tccattagta gtagtagtag tttcatacac tatggagact cagtgaaggg t                51


<210> 1271
<211> 13
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H3"

<400> 1271
Val Arg Asp Ser Gly His Gln Asp Tyr Arg Gly Asp Tyr 
1               5                   10              


<210> 1272
<211> 39
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H3"

<400> 1272
gtgagagact cgggccacca ggactaccgc ggggactac                              39


<210> 1273
<211> 333
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region"

<400> 1273
cagtctgtgg tgacgcagcc gccctcagtg tctggggccc cagggcagag ggtctccatc       60

tcctgcactg ggagcagctc caacatcggg gcaggttatg atgtacactg gtaccagcag      120

cttccaggaa cagcccccaa actcctcatc tatactaaca acaatcggcc ctcaggggtc      180

cctgaccgat tctctggctc caagtctggc acctcagcct ccctggccat caatgggctc      240

caggctgagg atgaggctga ttattactgc cagtcctatg acaggagcct gagtggttgg      300

gtgttcggcg gagggaccaa gctcaccgtc cta                                   333


<210> 1274
<211> 111
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region"

<400> 1274
Gln Ser Val Val Thr Gln Pro Pro Ser Val Ser Gly Ala Pro Gly Gln 
1               5                   10                  15      


Arg Val Ser Ile Ser Cys Thr Gly Ser Ser Ser Asn Ile Gly Ala Gly 
            20                  25                  30          


Tyr Asp Val His Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu 
        35                  40                  45              


Leu Ile Tyr Thr Asn Asn Asn Arg Pro Ser Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Asn Gly Leu 
65                  70                  75                  80  


Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Gln Ser Tyr Asp Arg Ser 
                85                  90                  95      


Leu Ser Gly Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 110     


<210> 1275
<211> 14
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L1"

<400> 1275
Thr Gly Ser Ser Ser Asn Ile Gly Ala Gly Tyr Asp Val His 
1               5                   10                  


<210> 1276
<211> 42
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L1"

<400> 1276
actgggagca gctccaacat cggggcaggt tatgatgtac ac                          42


<210> 1277
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L2"

<400> 1277
Thr Asn Asn Asn Arg Pro Ser 
1               5           


<210> 1278
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L2"

<400> 1278
actaacaaca atcggccctc a                                                 21


<210> 1279
<211> 11
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L3"

<400> 1279
Gln Ser Tyr Asp Arg Ser Leu Ser Gly Trp Val 
1               5                   10      


<210> 1280
<211> 33
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L3"

<400> 1280
cagtcctatg acaggagcct gagtggttgg gtg                                    33


<210> 1281
<211> 378
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region"

<400> 1281
caggtgcagc tggtggagtc tggtcctgcg ttggtgaaac ccacacagac cctcacactg       60

acctgcgcct tctctgggtt ctcactcacc actcgtggga tgtctgtgag ctggatccgt      120

cagcccccag ggaaggccct ggagtggctt gcacgcattg attgggatga tgataaatac      180

tacagcacct ctctgaagac caggctcacc atctccaagg acacctccaa aaaccaggtg      240

gtcctcacaa tgagcaacat ggaccctgtg gacacagcca cgtattactg tgcacgggcg      300

tctctctatg atagtggtgg ctattacctt tttttctttg actactgggg ccagggaacc      360

ctggtcaccg tctcctca                                                    378


<210> 1282
<211> 126
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region"

<400> 1282
Gln Val Gln Leu Val Glu Ser Gly Pro Ala Leu Val Lys Pro Thr Gln 
1               5                   10                  15      


Thr Leu Thr Leu Thr Cys Ala Phe Ser Gly Phe Ser Leu Thr Thr Arg 
            20                  25                  30          


Gly Met Ser Val Ser Trp Ile Arg Gln Pro Pro Gly Lys Ala Leu Glu 
        35                  40                  45              


Trp Leu Ala Arg Ile Asp Trp Asp Asp Asp Lys Tyr Tyr Ser Thr Ser 
    50                  55                  60                  


Leu Lys Thr Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Val 
65                  70                  75                  80  


Val Leu Thr Met Ser Asn Met Asp Pro Val Asp Thr Ala Thr Tyr Tyr 
                85                  90                  95      


Cys Ala Arg Ala Ser Leu Tyr Asp Ser Gly Gly Tyr Tyr Leu Phe Phe 
            100                 105                 110         


Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125     


<210> 1283
<211> 11
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H1"

<400> 1283
Phe Ser Leu Thr Thr Arg Gly Met Ser Val Ser 
1               5                   10      


<210> 1284
<211> 33
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H1"

<400> 1284
ttctcactca ccactcgtgg gatgtctgtg agc                                    33


<210> 1285
<211> 16
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H2"

<400> 1285
Arg Ile Asp Trp Asp Asp Asp Lys Tyr Tyr Ser Thr Ser Leu Lys Thr 
1               5                   10                  15      


<210> 1286
<211> 48
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H2"

<400> 1286
cgcattgatt gggatgatga taaatactac agcacctctc tgaagacc                    48


<210> 1287
<211> 18
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H3"

<400> 1287
Ala Arg Ala Ser Leu Tyr Asp Ser Gly Gly Tyr Tyr Leu Phe Phe Phe 
1               5                   10                  15      


Asp Tyr 
        


<210> 1288
<211> 54
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H3"

<400> 1288
gcacgggcgt ctctctatga tagtggtggc tattaccttt ttttctttga ctac             54


<210> 1289
<211> 321
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region"

<400> 1289
gatattgtga tgactcagtc tccatcctcc ctgtctgcat ctgttggaga cagagtcacc       60

atcacttgcc gggcaagcca gagcattggc agttatttaa attggtatca gcagaaacca      120

gggaaagtcc cgaaactcct gatctatgct gcatccaatt tgcaaggtgg ggtcccatca      180

aggtttcgtg gcagtggatc tgggacagat ttcactctca ccatcagcaa tctgcaacct      240

gaagattttg caagttacta ctgtcaactg agttacagta gcctttggac gttcggccaa      300

gggaccaagg tggaaatcaa a                                                321


<210> 1290
<211> 107
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region"

<400> 1290
Asp Ile Val Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Gly Ser Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Val Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Asn Leu Gln Gly Gly Val Pro Ser Arg Phe Arg Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Asn Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Ser Tyr Tyr Cys Gln Leu Ser Tyr Ser Ser Leu Trp 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210> 1291
<211> 11
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L1"

<400> 1291
Arg Ala Ser Gln Ser Ile Gly Ser Tyr Leu Asn 
1               5                   10      


<210> 1292
<211> 33
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L1"

<400> 1292
cgggcaagcc agagcattgg cagttattta aat                                    33


<210> 1293
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L2"

<400> 1293
Ala Ala Ser Asn Leu Gln Gly 
1               5           


<210> 1294
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L2"

<400> 1294
gctgcatcca atttgcaagg t                                                 21


<210> 1295
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L3"

<400> 1295
Gln Leu Ser Tyr Ser Ser Leu Trp Thr 
1               5                   


<210> 1296
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L3"

<400> 1296
caactgagtt acagtagcct ttggacg                                           27


<210> 1297
<211> 351
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region"

<400> 1297
caggtgcagc tggtggagtc tgggggaggc gtggtccagc ctgggaggtc cctgagagtc       60

tcctgtgcag cctctggatt tgacttcagt aactatgcca tgcactgggt ccgccaggct      120

ccaggcaagg ggctggagtg ggtggcactt atatcctatg atggaaataa taaagtctat      180

gcagactccg tgaagggccg attcaccgtc tccagagaca attccaaaaa cacactttat      240

ctgcaaatga acagcctgag acctgaagac acggctgtga tttactgtgc gaaagatggc      300

tatctggctc ctgacttctg gggccaggga accctggtca ccgtctcctc a               351


<210> 1298
<211> 117
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region"

<400> 1298
Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Val Ser Cys Ala Ala Ser Gly Phe Asp Phe Ser Asn Tyr 
            20                  25                  30          


Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Leu Ile Ser Tyr Asp Gly Asn Asn Lys Val Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Val Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Val Ile Tyr Cys 
                85                  90                  95      


Ala Lys Asp Gly Tyr Leu Ala Pro Asp Phe Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210> 1299
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H1"

<400> 1299
Phe Asp Phe Ser Asn Tyr Ala Met His 
1               5                   


<210> 1300
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H1"

<400> 1300
tttgacttca gtaactatgc catgcac                                           27


<210> 1301
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H2"

<400> 1301
Leu Ile Ser Tyr Asp Gly Asn Asn Lys Val Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210> 1302
<211> 51
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H2"

<400> 1302
cttatatcct atgatggaaa taataaagtc tatgcagact ccgtgaaggg c                51


<210> 1303
<211> 10
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H3"

<400> 1303
Ala Lys Asp Gly Tyr Leu Ala Pro Asp Phe 
1               5                   10  


<210> 1304
<211> 30
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H3"

<400> 1304
gcgaaagatg gctatctggc tcctgacttc                                        30


<210> 1305
<211> 330
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region"

<400> 1305
cagtcagtcc tgactcagcc tgcctccgtg tctgggtctc ctggacagtc gatcatcatc       60

tcctgcactg gaaccagcag tgacgttggt gaatatgact atgtctcctg gtaccaacac      120

cacccacaca aagcccccaa actcataatt tatgaggtca gtaatcggcc ctcaggggtt      180

tctaatcgct tctctggctc caagtctggc aacacggcct ccctgaccat ctctgggctc      240

caggctgagg acgaggctga ttattactgc agttcctaca caagcagtag cggtcaagcc      300

ttcggaactg ggaccaaggt caccgtccta                                       330


<210> 1306
<211> 110
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region"

<400> 1306
Gln Ser Val Leu Thr Gln Pro Ala Ser Val Ser Gly Ser Pro Gly Gln 
1               5                   10                  15      


Ser Ile Ile Ile Ser Cys Thr Gly Thr Ser Ser Asp Val Gly Glu Tyr 
            20                  25                  30          


Asp Tyr Val Ser Trp Tyr Gln His His Pro His Lys Ala Pro Lys Leu 
        35                  40                  45              


Ile Ile Tyr Glu Val Ser Asn Arg Pro Ser Gly Val Ser Asn Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Asn Thr Ala Ser Leu Thr Ile Ser Gly Leu 
65                  70                  75                  80  


Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Ser Ser Tyr Thr Ser Ser 
                85                  90                  95      


Ser Gly Gln Ala Phe Gly Thr Gly Thr Lys Val Thr Val Leu 
            100                 105                 110 


<210> 1307
<211> 14
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L1"

<400> 1307
Thr Gly Thr Ser Ser Asp Val Gly Glu Tyr Asp Tyr Val Ser 
1               5                   10                  


<210> 1308
<211> 42
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L1"

<400> 1308
actggaacca gcagtgacgt tggtgaatat gactatgtct cc                          42


<210> 1309
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L2"

<400> 1309
Glu Val Ser Asn Arg Pro Ser 
1               5           


<210> 1310
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L2"

<400> 1310
gaggtcagta atcggccctc a                                                 21


<210> 1311
<211> 10
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L3"

<400> 1311
Ser Ser Tyr Thr Ser Ser Ser Gly Gln Ala 
1               5                   10  


<210> 1312
<211> 30
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L3"

<400> 1312
agttcctaca caagcagtag cggtcaagcc                                        30


<210> 1313
<211> 372
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region"

<400> 1313
gaggtgcagc tggtggagtc tggaggaggc ttgatccagc ctggggggtc cctgagactc       60

tcctgtgcag cctctgggtt caccgtcagt agcaagtaca tgagctgggt ccgccaggct      120

ccagggaagg ggctggagtg ggtctcaatt atttatagtg gtggtagcac ataccacgca      180

gactccgtga agggccgatt caccatctcc agagacaact ccaagaacac actgtatctt      240

caaatgaaca gcctgagagc cgaggacacg gccgtgtatt actgtgcgag agatgattac      300

gatttttgga gtggcaacgg cccaccggag atggccgtct ggggccaggg gaccacggtc      360

accgtctcct ca                                                          372


<210> 1314
<211> 124
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region"

<400> 1314
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Ile Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Val Ser Ser Lys 
            20                  25                  30          


Tyr Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ile Ile Tyr Ser Gly Gly Ser Thr Tyr His Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Asp Asp Tyr Asp Phe Trp Ser Gly Asn Gly Pro Pro Glu Met Ala 
            100                 105                 110         


Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120                 


<210> 1315
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H1"

<400> 1315
Phe Thr Val Ser Ser Lys Tyr Met Ser 
1               5                   


<210> 1316
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H1"

<400> 1316
ttcaccgtca gtagcaagta catgagc                                           27


<210> 1317
<211> 16
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H2"

<400> 1317
Ile Ile Tyr Ser Gly Gly Ser Thr Tyr His Ala Asp Ser Val Lys Gly 
1               5                   10                  15      


<210> 1318
<211> 48
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H2"

<400> 1318
attatttata gtggtggtag cacataccac gcagactccg tgaagggc                    48


<210> 1319
<211> 18
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H3"

<400> 1319
Ala Arg Asp Asp Tyr Asp Phe Trp Ser Gly Asn Gly Pro Pro Glu Met 
1               5                   10                  15      


Ala Val 
        


<210> 1320
<211> 54
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H3"

<400> 1320
gcgagagatg attacgattt ttggagtggc aacggcccac cggagatggc cgtc             54


<210> 1321
<211> 321
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region"

<400> 1321
gacatccgga tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga cagagtcacc       60

atcacttgcc gggcgagtca gggcattagc aattatttag cctggtatca gcagaaacca      120

gggaaagttc ctaagctcct gatctatgct gcatccactt tgcaatcagg ggtcccatct      180

cggttcagtg gcagtggatc tgagacagat ttcactctca ccatcagcag cctgcagcct      240

gaagatgttg caacttatta ctgtcaaaag tataacagtg tccctctgac gttcggccaa      300

gggaccaagg tggaaatcaa a                                                321


<210> 1322
<211> 107
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region"

<400> 1322
Asp Ile Arg Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Ser Asn Tyr 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Val Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Thr Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Glu Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Val Ala Thr Tyr Tyr Cys Gln Lys Tyr Asn Ser Val Pro Leu 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210> 1323
<211> 11
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L1"

<400> 1323
Arg Ala Ser Gln Gly Ile Ser Asn Tyr Leu Ala 
1               5                   10      


<210> 1324
<211> 33
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L1"

<400> 1324
cgggcgagtc agggcattag caattattta gcc                                    33


<210> 1325
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L2"

<400> 1325
Ala Ala Ser Thr Leu Gln Ser 
1               5           


<210> 1326
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L2"

<400> 1326
gctgcatcca ctttgcaatc a                                                 21


<210> 1327
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L3"

<400> 1327
Gln Lys Tyr Asn Ser Val Pro Leu Thr 
1               5                   


<210> 1328
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L3"

<400> 1328
caaaagtata acagtgtccc tctgacg                                           27


<210> 1329
<211> 369
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region"

<400> 1329
caggtccagc tggtgcagtc tggagcagag gtgaaaaagc ccggggagtc tctgaagatc       60

tcctgtaaga cttctggata cagatttacc aattactgga tcggctgggt gcgccagatg      120

cccgggaaag gcctggagtg gatggggatc atctatcctg gtgactctga tgccagatac      180

agcccgtcct tccaaggcca ggtcaccttc tcagccgaca agtccatcag caccgcctac      240

ctgcactgga gcagcctgaa ggcctcggac accgccatgt attactgtgc gagacaagat      300

gacagtggct gggccgactt ctttcccttt gactactggg gccagggaac cctggtcacc      360

gtctcctca                                                              369


<210> 1330
<211> 123
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region"

<400> 1330
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu 
1               5                   10                  15      


Ser Leu Lys Ile Ser Cys Lys Thr Ser Gly Tyr Arg Phe Thr Asn Tyr 
            20                  25                  30          


Trp Ile Gly Trp Val Arg Gln Met Pro Gly Lys Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Ile Ile Tyr Pro Gly Asp Ser Asp Ala Arg Tyr Ser Pro Ser Phe 
    50                  55                  60                  


Gln Gly Gln Val Thr Phe Ser Ala Asp Lys Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Leu His Trp Ser Ser Leu Lys Ala Ser Asp Thr Ala Met Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gln Asp Asp Ser Gly Trp Ala Asp Phe Phe Pro Phe Asp Tyr 
            100                 105                 110         


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120             


<210> 1331
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H1"

<400> 1331
Tyr Arg Phe Thr Asn Tyr Trp Ile Gly 
1               5                   


<210> 1332
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H1"

<400> 1332
tacagattta ccaattactg gatcggc                                           27


<210> 1333
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H2"

<400> 1333
Ile Ile Tyr Pro Gly Asp Ser Asp Ala Arg Tyr Ser Pro Ser Phe Gln 
1               5                   10                  15      


Gly 
    


<210> 1334
<211> 51
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H2"

<400> 1334
atcatctatc ctggtgactc tgatgccaga tacagcccgt ccttccaagg c                51


<210> 1335
<211> 16
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H3"

<400> 1335
Ala Arg Gln Asp Asp Ser Gly Trp Ala Asp Phe Phe Pro Phe Asp Tyr 
1               5                   10                  15      


<210> 1336
<211> 48
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H3"

<400> 1336
gcgagacaag atgacagtgg ctgggccgac ttctttccct ttgactac                    48


<210> 1337
<211> 324
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region"

<400> 1337
gaaattgtgt tgacgcagtc tccaggcacc ctgtctttgt ctccagggga aagagccacc       60

ctctcctgca gggccagtca cagttttagc agcacctact tagcctggta ccagcagaaa      120

cctggccagg ctcccaggct cctcatctat gctgcatcca acagggccac tggcatccca      180

gacaggttca gtggcagtgg gtctgggaca gacttcactc tcaccatcag cagactggag      240

cctgaagatt ttgcagtgta tttctgtcag cagtatgata gctcaccgtg gacgttcggc      300

caagggacca agctggagat caaa                                             324


<210> 1338
<211> 108
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region"

<400> 1338
Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser His Ser Phe Ser Ser Thr 
            20                  25                  30          


Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu 
        35                  40                  45              


Ile Tyr Ala Ala Ser Asn Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu 
65                  70                  75                  80  


Pro Glu Asp Phe Ala Val Tyr Phe Cys Gln Gln Tyr Asp Ser Ser Pro 
                85                  90                  95      


Trp Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105             


<210> 1339
<211> 12
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L1"

<400> 1339
Arg Ala Ser His Ser Phe Ser Ser Thr Tyr Leu Ala 
1               5                   10          


<210> 1340
<211> 36
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L1"

<400> 1340
agggccagtc acagttttag cagcacctac ttagcc                                 36


<210> 1341
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L2"

<400> 1341
Ala Ala Ser Asn Arg Ala Thr 
1               5           


<210> 1342
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L2"

<400> 1342
gctgcatcca acagggccac t                                                 21


<210> 1343
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L3"

<400> 1343
Gln Gln Tyr Asp Ser Ser Pro Trp Thr 
1               5                   


<210> 1344
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L3"

<400> 1344
cagcagtatg atagctcacc gtggacg                                           27


<210> 1345
<211> 369
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region"

<400> 1345
caggtccagc tggtacagtc tggggctgag gtgaagaagc ctgggtcctc ggtgaaggtc       60

tcctgcagga cttctggagg caccttcagc agcttttcta tcagctgggt gcgacaggcc      120

cctggacaag gacttgaatg gatgggaggg atcatcccta tctttgggac agcaaactac      180

gcaaagaaat tccagggcag agtcacaatt accgcggacg aatccacgga cacagcctat      240

atggaactga ggagcctgag atctgaggac acggccgtct attactgtgc gagagattcc      300

cccaaaatat cagcaactga atattacttt gactactggg gccagggaac cctggtcacc      360

gtctcctca                                                              369


<210> 1346
<211> 123
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region"

<400> 1346
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Arg Thr Ser Gly Gly Thr Phe Ser Ser Phe 
            20                  25                  30          


Ser Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Gly Ile Ile Pro Ile Phe Gly Thr Ala Asn Tyr Ala Lys Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Asp Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Arg Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Ser Pro Lys Ile Ser Ala Thr Glu Tyr Tyr Phe Asp Tyr 
            100                 105                 110         


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120             


<210> 1347
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H1"

<400> 1347
Gly Thr Phe Ser Ser Phe Ser Ile Ser 
1               5                   


<210> 1348
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H1"

<400> 1348
ggcaccttca gcagcttttc tatcagc                                           27


<210> 1349
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H2"

<400> 1349
Gly Ile Ile Pro Ile Phe Gly Thr Ala Asn Tyr Ala Lys Lys Phe Gln 
1               5                   10                  15      


Gly 
    


<210> 1350
<211> 51
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H2"

<400> 1350
gggatcatcc ctatctttgg gacagcaaac tacgcaaaga aattccaggg c                51


<210> 1351
<211> 16
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H3"

<400> 1351
Ala Arg Asp Ser Pro Lys Ile Ser Ala Thr Glu Tyr Tyr Phe Asp Tyr 
1               5                   10                  15      


<210> 1352
<211> 48
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H3"

<400> 1352
gcgagagatt cccccaaaat atcagcaact gaatattact ttgactac                    48


<210> 1353
<211> 321
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region"

<400> 1353
gacatccagg tgacccagtc tccttccacc ctgtctgcat ctgtaggaga cagagtcacc       60

atcacttgcc gggccagtca gagttttact agttggttgg cctggtatca gcagaaacca      120

gggaaagccc ctaagctcct gatctataag gcgtctactt tagacagtgg ggtcccatca      180

aggttcagcg gcagtggatc tgggacagaa ttcactctca ccatcaacgg cctgcagcct      240

gatgattttg caacttacta ctgccaacac tatgatagtt attcggggac cttcggccaa      300

gggacacgac tggagattaa a                                                321


<210> 1354
<211> 107
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region"

<400> 1354
Asp Ile Gln Val Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Phe Thr Ser Trp 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Lys Ala Ser Thr Leu Asp Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Asn Gly Leu Gln Pro 
65                  70                  75                  80  


Asp Asp Phe Ala Thr Tyr Tyr Cys Gln His Tyr Asp Ser Tyr Ser Gly 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Arg Leu Glu Ile Lys 
            100                 105         


<210> 1355
<211> 11
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L1"

<400> 1355
Arg Ala Ser Gln Ser Phe Thr Ser Trp Leu Ala 
1               5                   10      


<210> 1356
<211> 33
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L1"

<400> 1356
cgggccagtc agagttttac tagttggttg gcc                                    33


<210> 1357
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L2"

<400> 1357
Lys Ala Ser Thr Leu Asp Ser 
1               5           


<210> 1358
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L2"

<400> 1358
aaggcgtcta ctttagacag t                                                 21


<210> 1359
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L3"

<400> 1359
Gln His Tyr Asp Ser Tyr Ser Gly Thr 
1               5                   


<210> 1360
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L3"

<400> 1360
caacactatg atagttattc ggggacc                                           27


<210> 1361
<211> 354
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region"

<400> 1361
gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgagactc       60

tcctgtgcag cctctggatt cacctttagc agctacgcca tgagctgggt ccgccagatt      120

ccagggaagg ggctggagtg ggtctcaaca atcaatatta gtggtggtag tacatactac      180

gcagactccg tgaagggccg gttcaccatc tccagagaca attccaggga cacggtgttt      240

ctacaaatga atggcctgag agccgaggac acggccctat attactgcgc gaggggatat      300

catatagact ggtttgactt ttggggccag ggaaccctgg tcaccgtctc ctca            354


<210> 1362
<211> 118
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region"

<400> 1362
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Ile Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Thr Ile Asn Ile Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Arg Asp Thr Val Phe 
65                  70                  75                  80  


Leu Gln Met Asn Gly Leu Arg Ala Glu Asp Thr Ala Leu Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Tyr His Ile Asp Trp Phe Asp Phe Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser 
        115             


<210> 1363
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H1"

<400> 1363
Phe Thr Phe Ser Ser Tyr Ala Met Ser 
1               5                   


<210> 1364
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H1"

<400> 1364
ttcaccttta gcagctacgc catgagc                                           27


<210> 1365
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H2"

<400> 1365
Thr Ile Asn Ile Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210> 1366
<211> 51
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H2"

<400> 1366
acaatcaata ttagtggtgg tagtacatac tacgcagact ccgtgaaggg c                51


<210> 1367
<211> 11
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H3"

<400> 1367
Ala Arg Gly Tyr His Ile Asp Trp Phe Asp Phe 
1               5                   10      


<210> 1368
<211> 33
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H3"

<400> 1368
gcgaggggat atcatataga ctggtttgac ttt                                    33


<210> 1369
<211> 321
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region"

<400> 1369
gatattgtgc tgactcagac tccatcttcc gtgtctgcat ctgtaggaga cagagtcacc       60

atcacttgtc gggcgagtca ggatattggc agctggttag cctggtatca gcagaaacca      120

gggaaagccc ctcaattcct gatctatgct gcatcccaat tgcaaagtgg ggtcccatca      180

aggttcagcg gcagtggatc tgggacagat ttcactctta ccatcagcag cctgcagcct      240

gaagattttg caacttacta ttgtcaacag gctaaaagtt tacctcggac tttcggcgga      300

gggaccaaag tggatatcaa a                                                321


<210> 1370
<211> 107
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region"

<400> 1370
Asp Ile Val Leu Thr Gln Thr Pro Ser Ser Val Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Ile Gly Ser Trp 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Gln Phe Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Gln Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ala Lys Ser Leu Pro Arg 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Val Asp Ile Lys 
            100                 105         


<210> 1371
<211> 11
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L1"

<400> 1371
Arg Ala Ser Gln Asp Ile Gly Ser Trp Leu Ala 
1               5                   10      


<210> 1372
<211> 33
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L1"

<400> 1372
cgggcgagtc aggatattgg cagctggtta gcc                                    33


<210> 1373
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L2"

<400> 1373
Ala Ala Ser Gln Leu Gln Ser 
1               5           


<210> 1374
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L2"

<400> 1374
gctgcatccc aattgcaaag t                                                 21


<210> 1375
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L3"

<400> 1375
Gln Gln Ala Lys Ser Leu Pro Arg Thr 
1               5                   


<210> 1376
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L3"

<400> 1376
caacaggcta aaagtttacc tcggact                                           27


<210> 1377
<211> 390
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region"

<400> 1377
gaggtgcagc tgttggagtc tggaggaggc ttgatccagc ctggggggtc cctgagactc       60

tcctgtggag cctctgggtt caccgtcact ggcaactaca tgcattgggt ccgccaggct      120

ccagggaagg ggctggagtg ggtctcagtt atttatgccg gttctagcac atattacgca      180

gactccgtga ggggccgatt caccatctcc agagacaagg ccaggaacac gttgtttctt      240

caaatgaata gactgagagc cgaggacacg gccgtgtatt attgtgcgag agcgggggta      300

gttggggaag atagaagtgg ctggtacggt cccgattatt tccacggttt ggacgtctgg      360

ggccaaggga ccacggtcac cgtctcctca                                       390


<210> 1378
<211> 130
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region"

<400> 1378
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Ile Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Gly Ala Ser Gly Phe Thr Val Thr Gly Asn 
            20                  25                  30          


Tyr Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Val Ile Tyr Ala Gly Ser Ser Thr Tyr Tyr Ala Asp Ser Val Arg 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Lys Ala Arg Asn Thr Leu Phe Leu 
65                  70                  75                  80  


Gln Met Asn Arg Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Ala Gly Val Val Gly Glu Asp Arg Ser Gly Trp Tyr Gly Pro Asp 
            100                 105                 110         


Tyr Phe His Gly Leu Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val 
        115                 120                 125             


Ser Ser 
    130 


<210> 1379
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H1"

<400> 1379
Phe Thr Val Thr Gly Asn Tyr Met His 
1               5                   


<210> 1380
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H1"

<400> 1380
ttcaccgtca ctggcaacta catgcat                                           27


<210> 1381
<211> 16
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H2"

<400> 1381
Val Ile Tyr Ala Gly Ser Ser Thr Tyr Tyr Ala Asp Ser Val Arg Gly 
1               5                   10                  15      


<210> 1382
<211> 48
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H2"

<400> 1382
gttatttatg ccggttctag cacatattac gcagactccg tgaggggc                    48


<210> 1383
<211> 24
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H3"

<400> 1383
Ala Arg Ala Gly Val Val Gly Glu Asp Arg Ser Gly Trp Tyr Gly Pro 
1               5                   10                  15      


Asp Tyr Phe His Gly Leu Asp Val 
            20                  


<210> 1384
<211> 72
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H3"

<400> 1384
gcgagagcgg gggtagttgg ggaagataga agtggctggt acggtcccga ttatttccac       60

ggtttggacg tc                                                           72


<210> 1385
<211> 324
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region"

<400> 1385
gaaacgacac tcacgcagtc tccaggcacc ctgtctttgt ctccagggga aagagccacc       60

ctctcctgca gggccagtca gagtattcgc aacaactact tagcctggta ccagcaaaaa      120

cctggccagc ctcccaggct cctcatctat ggtgaatcca gaagggccac tggcatccca      180

ggcaggttca gtggcagtgg gtctgggaca gacttcactc tcaccatcag cagcctggag      240

cctgaagatt ttgcagtgta ttactgtcag cagtatggtg gctcaccgta cacttttggc      300

caggggacca aggtggatat caaa                                             324


<210> 1386
<211> 108
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region"

<400> 1386
Glu Thr Thr Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Ile Arg Asn Asn 
            20                  25                  30          


Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro Arg Leu Leu 
        35                  40                  45              


Ile Tyr Gly Glu Ser Arg Arg Ala Thr Gly Ile Pro Gly Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu 
65                  70                  75                  80  


Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Gly Gly Ser Pro 
                85                  90                  95      


Tyr Thr Phe Gly Gln Gly Thr Lys Val Asp Ile Lys 
            100                 105             


<210> 1387
<211> 12
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L1"

<400> 1387
Arg Ala Ser Gln Ser Ile Arg Asn Asn Tyr Leu Ala 
1               5                   10          


<210> 1388
<211> 36
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L1"

<400> 1388
agggccagtc agagtattcg caacaactac ttagcc                                 36


<210> 1389
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L2"

<400> 1389
Gly Glu Ser Arg Arg Ala Thr 
1               5           


<210> 1390
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L2"

<400> 1390
ggtgaatcca gaagggccac t                                                 21


<210> 1391
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L3"

<400> 1391
Gln Gln Tyr Gly Gly Ser Pro Tyr Thr 
1               5                   


<210> 1392
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L3"

<400> 1392
cagcagtatg gtggctcacc gtacact                                           27


<210> 1393
<211> 378
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region"

<400> 1393
caggtccagc ttgtgcagtc tggggctgag gtgaagaagc ctgggtcctc ggtgagggtc       60

tcctgcgagg cttctggagg caccttcagc acctatgcta ttagctgggt gcgacaggcc      120

cctggactag ggcttgagtg gatgggaggg atccacccca tctctggtac agcaaactac      180

gcacagagct tccaggacag actcaccatt accgtggaca agtccacgag cacagcctac      240

atggacctga gcagcctgag atctgaggac acggccatat attattgtgc gagagttggt      300

ctgggtcgca cttggattta tgatacaatg ggttaccttg actactgggg ccagggaacc      360

ctggtcaccg tctcctca                                                    378


<210> 1394
<211> 126
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region"

<400> 1394
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Arg Val Ser Cys Glu Ala Ser Gly Gly Thr Phe Ser Thr Tyr 
            20                  25                  30          


Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Leu Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Gly Ile His Pro Ile Ser Gly Thr Ala Asn Tyr Ala Gln Ser Phe 
    50                  55                  60                  


Gln Asp Arg Leu Thr Ile Thr Val Asp Lys Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Asp Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Ile Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Val Gly Leu Gly Arg Thr Trp Ile Tyr Asp Thr Met Gly Tyr 
            100                 105                 110         


Leu Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125     


<210> 1395
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H1"

<400> 1395
Gly Thr Phe Ser Thr Tyr Ala Ile Ser 
1               5                   


<210> 1396
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H1"

<400> 1396
ggcaccttca gcacctatgc tattagc                                           27


<210> 1397
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H2"

<400> 1397
Gly Ile His Pro Ile Ser Gly Thr Ala Asn Tyr Ala Gln Ser Phe Gln 
1               5                   10                  15      


Asp 
    


<210> 1398
<211> 51
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H2"

<400> 1398
gggatccacc ccatctctgg tacagcaaac tacgcacaga gcttccagga c                51


<210> 1399
<211> 19
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H3"

<400> 1399
Ala Arg Val Gly Leu Gly Arg Thr Trp Ile Tyr Asp Thr Met Gly Tyr 
1               5                   10                  15      


Leu Asp Tyr 
            


<210> 1400
<211> 57
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H3"

<400> 1400
gcgagagttg gtctgggtcg cacttggatt tatgatacaa tgggttacct tgactac          57


<210> 1401
<211> 324
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region"

<400> 1401
gaaattgtat tgacacagtc tccagccacc ctgtctttgt ctccagggga gagagtcacc       60

ctctcctgca gggccagtca gagtgttaac gactacttag cctggtacca acaaaaacct      120

ggccaggctc ccaggctcct catctatgat gcatccaaca gggccactgg catcccagcc      180

aggttcagtg gcagtgggtc tgggacagac ttcactctca ccatcagcag cctagagcct      240

gaagattttg cagtttatta ctgtcagcac cgtaccaact ggccttccct cactttcggc      300

ggagggacca aggtggaaat caaa                                             324


<210> 1402
<211> 108
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region"

<400> 1402
Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Val Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Asn Asp Tyr 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 
        35                  40                  45              


Tyr Asp Ala Ser Asn Arg Ala Thr Gly Ile Pro Ala Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Val Tyr Tyr Cys Gln His Arg Thr Asn Trp Pro Ser 
                85                  90                  95      


Leu Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105             


<210> 1403
<211> 11
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L1"

<400> 1403
Arg Ala Ser Gln Ser Val Asn Asp Tyr Leu Ala 
1               5                   10      


<210> 1404
<211> 33
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L1"

<400> 1404
agggccagtc agagtgttaa cgactactta gcc                                    33


<210> 1405
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L2"

<400> 1405
Asp Ala Ser Asn Arg Ala Thr 
1               5           


<210> 1406
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L2"

<400> 1406
gatgcatcca acagggccac t                                                 21


<210> 1407
<211> 10
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L3"

<400> 1407
Gln His Arg Thr Asn Trp Pro Ser Leu Thr 
1               5                   10  


<210> 1408
<211> 30
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L3"

<400> 1408
cagcaccgta ccaactggcc ttccctcact                                        30


<210> 1409
<211> 357
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region"

<400> 1409
gaggtgcagc tggtggagtc tgggggaggc ctggtcaagc ctggggggtc cctgagactc       60

tcctgtgcag cctcgggatt caccatcagt ggttataaca tgttctgggt ccgccagcct      120

ccggggaagg ggctggagtg ggtctcatcc attactgctg gtagtagtta tttaaactat      180

gcagactcag tgaagggccg tttcatcgtc tccagagaca acgccaagaa ttcactgtat      240

ctgcaaatga acagcctgag agccgaggac acggctgttt atttctgtgc gagagcacct      300

cttttacccg ctatgatgga cctctggggc caagggacca cggtcaccgt ctcctca         357


<210> 1410
<211> 119
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region"

<400> 1410
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Ile Ser Gly Tyr 
            20                  25                  30          


Asn Met Phe Trp Val Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ser Ile Thr Ala Gly Ser Ser Tyr Leu Asn Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Ile Val Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Phe Cys 
                85                  90                  95      


Ala Arg Ala Pro Leu Leu Pro Ala Met Met Asp Leu Trp Gly Gln Gly 
            100                 105                 110         


Thr Thr Val Thr Val Ser Ser 
        115                 


<210> 1411
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H1"

<400> 1411
Phe Thr Ile Ser Gly Tyr Asn Met Phe 
1               5                   


<210> 1412
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H1"

<400> 1412
ttcaccatca gtggttataa catgttc                                           27


<210> 1413
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H2"

<400> 1413
Ser Ile Thr Ala Gly Ser Ser Tyr Leu Asn Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210> 1414
<211> 51
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H2"

<400> 1414
tccattactg ctggtagtag ttatttaaac tatgcagact cagtgaaggg c                51


<210> 1415
<211> 12
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H3"

<400> 1415
Ala Arg Ala Pro Leu Leu Pro Ala Met Met Asp Leu 
1               5                   10          


<210> 1416
<211> 36
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H3"

<400> 1416
gcgagagcac ctcttttacc cgctatgatg gacctc                                 36


<210> 1417
<211> 333
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region"

<400> 1417
cagtctgtgg tgacgcagcc gccctcagtg tctggggccc cagggcagag ggtcaccatc       60

tcctgcactg ggagcagctc caacatcggg gcaggttatg atgtacactg gtaccagcaa      120

cttccaggaa cagcccccaa actcctcatc tatactaaca acaatcggcc ctcaggggtc      180

cctgaccgat tctctggctc caagtctggc acctcagcct ccctggccat cactgggctc      240

caggctgagg atgaggctga ctattactgc cagtcctatg acagaagcct gaatggttat      300

gtcttcggaa ctgggaccac ggtcaccgtc cta                                   333


<210> 1418
<211> 111
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region"

<400> 1418
Gln Ser Val Val Thr Gln Pro Pro Ser Val Ser Gly Ala Pro Gly Gln 
1               5                   10                  15      


Arg Val Thr Ile Ser Cys Thr Gly Ser Ser Ser Asn Ile Gly Ala Gly 
            20                  25                  30          


Tyr Asp Val His Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu 
        35                  40                  45              


Leu Ile Tyr Thr Asn Asn Asn Arg Pro Ser Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Thr Gly Leu 
65                  70                  75                  80  


Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Gln Ser Tyr Asp Arg Ser 
                85                  90                  95      


Leu Asn Gly Tyr Val Phe Gly Thr Gly Thr Thr Val Thr Val Leu 
            100                 105                 110     


<210> 1419
<211> 14
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L1"

<400> 1419
Thr Gly Ser Ser Ser Asn Ile Gly Ala Gly Tyr Asp Val His 
1               5                   10                  


<210> 1420
<211> 42
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L1"

<400> 1420
actgggagca gctccaacat cggggcaggt tatgatgtac ac                          42


<210> 1421
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L2"

<400> 1421
Thr Asn Asn Asn Arg Pro Ser 
1               5           


<210> 1422
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L2"

<400> 1422
actaacaaca atcggccctc a                                                 21


<210> 1423
<211> 11
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L3"

<400> 1423
Gln Ser Tyr Asp Arg Ser Leu Asn Gly Tyr Val 
1               5                   10      


<210> 1424
<211> 33
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L3"

<400> 1424
cagtcctatg acagaagcct gaatggttat gtc                                    33


<210> 1425
<211> 372
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region"

<400> 1425
gaggtgcagc tggtggagtc tgggggaggc ctggtcaagc ctggggggtc cctgagactc       60

tcctgtgcag cccctggatt caccatcagg agttatacca tgtactgggt ccgccaggct      120

ccagggaagg ggctggagtg ggtcgcatcc attagtagta gtagtagtta catacactat      180

ggagactcag tgaagggccg attcaccatc gccagagaca atgccaagaa ctcactgtat      240

ctgcaaatga acagcctgag agccgaggac acggctgtgt attactgtgt gagagatcat      300

tgtactggtg gaagctgcta cttaaacggt atggacgtct ggggccaagg gaccacggtc      360

accgtctcct ca                                                          372


<210> 1426
<211> 124
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region"

<400> 1426
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Pro Gly Phe Thr Ile Arg Ser Tyr 
            20                  25                  30          


Thr Met Tyr Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Ser Ile Ser Ser Ser Ser Ser Tyr Ile His Tyr Gly Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ala Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Val Arg Asp His Cys Thr Gly Gly Ser Cys Tyr Leu Asn Gly Met Asp 
            100                 105                 110         


Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120                 


<210> 1427
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H1"

<400> 1427
Phe Thr Ile Arg Ser Tyr Thr Met Tyr 
1               5                   


<210> 1428
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H1"

<400> 1428
ttcaccatca ggagttatac catgtac                                           27


<210> 1429
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H2"

<400> 1429
Ser Ile Ser Ser Ser Ser Ser Tyr Ile His Tyr Gly Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210> 1430
<211> 51
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H2"

<400> 1430
tccattagta gtagtagtag ttacatacac tatggagact cagtgaaggg c                51


<210> 1431
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H3"

<400> 1431
Val Arg Asp His Cys Thr Gly Gly Ser Cys Tyr Leu Asn Gly Met Asp 
1               5                   10                  15      


Val 
    


<210> 1432
<211> 51
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H3"

<400> 1432
gtgagagatc attgtactgg tggaagctgc tacttaaacg gtatggacgt c                51


<210> 1433
<211> 333
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region"

<400> 1433
cagcctgtgc tgactcagcc accctcagtg tctggggccc cagggcagag ggtcaccatc       60

tcctgcactg ggaccagctc caacatcggg gcaggttatg atgtacactg gtaccagcag      120

cttccaggaa cagcccccaa actcctcatc tatggtaaca acaatcggcc ctcaggggtc      180

cctgaccgat tctctggctc caagtctggc acctcagcct ccctggccat cactgggctc      240

caggctgagg atgaggctga ttattactgc cagtcctatg acagcagcct gagcggttcg      300

gtattcggcg gagggaccaa gctcaccgtc cta                                   333


<210> 1434
<211> 111
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region"

<400> 1434
Gln Pro Val Leu Thr Gln Pro Pro Ser Val Ser Gly Ala Pro Gly Gln 
1               5                   10                  15      


Arg Val Thr Ile Ser Cys Thr Gly Thr Ser Ser Asn Ile Gly Ala Gly 
            20                  25                  30          


Tyr Asp Val His Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu 
        35                  40                  45              


Leu Ile Tyr Gly Asn Asn Asn Arg Pro Ser Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Thr Gly Leu 
65                  70                  75                  80  


Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Gln Ser Tyr Asp Ser Ser 
                85                  90                  95      


Leu Ser Gly Ser Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 110     


<210> 1435
<211> 14
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L1"

<400> 1435
Thr Gly Thr Ser Ser Asn Ile Gly Ala Gly Tyr Asp Val His 
1               5                   10                  


<210> 1436
<211> 42
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L1"

<400> 1436
actgggacca gctccaacat cggggcaggt tatgatgtac ac                          42


<210> 1437
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L2"

<400> 1437
Gly Asn Asn Asn Arg Pro Ser 
1               5           


<210> 1438
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L2"

<400> 1438
ggtaacaaca atcggccctc a                                                 21


<210> 1439
<211> 11
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L3"

<400> 1439
Gln Ser Tyr Asp Ser Ser Leu Ser Gly Ser Val 
1               5                   10      


<210> 1440
<211> 33
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L3"

<400> 1440
cagtcctatg acagcagcct gagcggttcg gta                                    33


<210> 1441
<211> 372
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region"

<400> 1441
gaggtgcagc tggtggagtc tggaggaggc ttgatccagc ctggggggtc cctgagactc       60

tcctgtgcag cctctgggtt caccgtcagt agcaagtaca tgagctgggt ccgccaggct      120

ccagggaagg ggctggagtg ggtctcaatt atttatagtg gtggtagcac atactacgca      180

gactccgtga agggccgatt caccatctcc agagacaatt ccaagaacac actgtatctt      240

caaatgaaca gcctgagagc cgaggacacg gccgtgtatt actgtgcgag agatgattac      300

gatttttgga gtggcaacgg cccaccggag atggccgtct ggggccaggg gaccacggtc      360

accgtctcct ca                                                          372


<210> 1442
<211> 124
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region"

<400> 1442
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Ile Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Val Ser Ser Lys 
            20                  25                  30          


Tyr Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ile Ile Tyr Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Asp Asp Tyr Asp Phe Trp Ser Gly Asn Gly Pro Pro Glu Met Ala 
            100                 105                 110         


Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120                 


<210> 1443
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H1"

<400> 1443
Phe Thr Val Ser Ser Lys Tyr Met Ser 
1               5                   


<210> 1444
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H1"

<400> 1444
ttcaccgtca gtagcaagta catgagc                                           27


<210> 1445
<211> 16
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H2"

<400> 1445
Ile Ile Tyr Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val Lys Gly 
1               5                   10                  15      


<210> 1446
<211> 48
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H2"

<400> 1446
attatttata gtggtggtag cacatactac gcagactccg tgaagggc                    48


<210> 1447
<211> 18
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H3"

<400> 1447
Ala Arg Asp Asp Tyr Asp Phe Trp Ser Gly Asn Gly Pro Pro Glu Met 
1               5                   10                  15      


Ala Val 
        


<210> 1448
<211> 54
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H3"

<400> 1448
gcgagagatg attacgattt ttggagtggc aacggcccac cggagatggc cgtc             54


<210> 1449
<211> 321
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region"

<400> 1449
gacatgagac tcacccagtc tccatcctcc ctgtctgcgt ctgtaggaga cagagtcacc       60

atcacttgcc gggcgagtca gggcattagc aattatttag cctggtatca gcagagacca      120

gggaaagttc ctcagctcct gatctatact gcatccactt tgcaatcagg ggtcccatct      180

cggttcagtg gcagtggatc tgagacagat ttcactctca ccatcagcag cctgcagcct      240

gaagatgttg caacttatta ctgtcaaaag tatgacagtg tccctctgac gttcggccaa      300

gggaccaagg tggaaatcaa a                                                321


<210> 1450
<211> 107
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region"

<400> 1450
Asp Met Arg Leu Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Ser Asn Tyr 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Arg Pro Gly Lys Val Pro Gln Leu Leu Ile 
        35                  40                  45              


Tyr Thr Ala Ser Thr Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Glu Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Val Ala Thr Tyr Tyr Cys Gln Lys Tyr Asp Ser Val Pro Leu 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210> 1451
<211> 11
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L1"

<400> 1451
Arg Ala Ser Gln Gly Ile Ser Asn Tyr Leu Ala 
1               5                   10      


<210> 1452
<211> 33
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L1"

<400> 1452
cgggcgagtc agggcattag caattattta gcc                                    33


<210> 1453
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L2"

<400> 1453
Thr Ala Ser Thr Leu Gln Ser 
1               5           


<210> 1454
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L2"

<400> 1454
actgcatcca ctttgcaatc a                                                 21


<210> 1455
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L3"

<400> 1455
Gln Lys Tyr Asp Ser Val Pro Leu Thr 
1               5                   


<210> 1456
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L3"

<400> 1456
caaaagtatg acagtgtccc tctgacg                                           27


<210> 1457
<211> 369
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region"

<400> 1457
gaggtgcagc tggtggagtc tggtcctgcg ctggtgaaac ccacacagac cctcacactg       60

acctgcaccg tctcgggggg tgttgagaga atgagtgtga gttgggtccg tcagccccca      120

gggaaggccc tggagtggct tgcacgcatt gattgggatg atgataaata ctacaacaca      180

tttctgaaga ccaggctcac catctccaag ggcacctcca aaaacgaggt ggtccttaca      240

atgaccaaca tggaccctga agacacagca atttattact gtgcacggac gaatcgctat      300

gataaaagtg gttattacct ttattacctt gactactggg gccagggaac cctggtcact      360

gtctcctca                                                              369


<210> 1458
<211> 123
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region"

<400> 1458
Glu Val Gln Leu Val Glu Ser Gly Pro Ala Leu Val Lys Pro Thr Gln 
1               5                   10                  15      


Thr Leu Thr Leu Thr Cys Thr Val Ser Gly Gly Val Glu Arg Met Ser 
            20                  25                  30          


Val Ser Trp Val Arg Gln Pro Pro Gly Lys Ala Leu Glu Trp Leu Ala 
        35                  40                  45              


Arg Ile Asp Trp Asp Asp Asp Lys Tyr Tyr Asn Thr Phe Leu Lys Thr 
    50                  55                  60                  


Arg Leu Thr Ile Ser Lys Gly Thr Ser Lys Asn Glu Val Val Leu Thr 
65                  70                  75                  80  


Met Thr Asn Met Asp Pro Glu Asp Thr Ala Ile Tyr Tyr Cys Ala Arg 
                85                  90                  95      


Thr Asn Arg Tyr Asp Lys Ser Gly Tyr Tyr Leu Tyr Tyr Leu Asp Tyr 
            100                 105                 110         


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120             


<210> 1459
<211> 8
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H1"

<400> 1459
Gly Val Glu Arg Met Ser Val Ser 
1               5               


<210> 1460
<211> 24
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H1"

<400> 1460
ggtgttgaga gaatgagtgt gagt                                              24


<210> 1461
<211> 16
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H2"

<400> 1461
Arg Ile Asp Trp Asp Asp Asp Lys Tyr Tyr Asn Thr Phe Leu Lys Thr 
1               5                   10                  15      


<210> 1462
<211> 48
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H2"

<400> 1462
cgcattgatt gggatgatga taaatactac aacacatttc tgaagacc                    48


<210> 1463
<211> 18
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H3"

<400> 1463
Ala Arg Thr Asn Arg Tyr Asp Lys Ser Gly Tyr Tyr Leu Tyr Tyr Leu 
1               5                   10                  15      


Asp Tyr 
        


<210> 1464
<211> 54
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H3"

<400> 1464
gcacggacga atcgctatga taaaagtggt tattaccttt attaccttga ctac             54


<210> 1465
<211> 321
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region"

<400> 1465
gacatccaga tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga caaagtcacc       60

atcacttgcc gggcaagtca gaccattgcc agttatgtaa attggtatca gcagcaccca      120

gggaaagccc ctaagctcct aatctatctt gcatcccgtt tgcaaagtgg tgccccatca      180

aggttcagtg gcagtggatc tgggacagat ttcactctca ccatcctcaa tctgcaacct      240

gaagattttg caacttacta ctgtcaacag agttacagtt cgtttttcac tttcggccct      300

gggaccaagg tggaaatcaa a                                                321


<210> 1466
<211> 107
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region"

<400> 1466
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Lys Val Thr Ile Thr Cys Arg Ala Ser Gln Thr Ile Ala Ser Tyr 
            20                  25                  30          


Val Asn Trp Tyr Gln Gln His Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Leu Ala Ser Arg Leu Gln Ser Gly Ala Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Leu Asn Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Tyr Ser Ser Phe Phe 
                85                  90                  95      


Thr Phe Gly Pro Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210> 1467
<211> 11
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L1"

<400> 1467
Arg Ala Ser Gln Thr Ile Ala Ser Tyr Val Asn 
1               5                   10      


<210> 1468
<211> 33
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L1"

<400> 1468
cgggcaagtc agaccattgc cagttatgta aat                                    33


<210> 1469
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L2"

<400> 1469
Leu Ala Ser Arg Leu Gln Ser 
1               5           


<210> 1470
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L2"

<400> 1470
cttgcatccc gtttgcaaag t                                                 21


<210> 1471
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L3"

<400> 1471
Gln Gln Ser Tyr Ser Ser Phe Phe Thr 
1               5                   


<210> 1472
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L3"

<400> 1472
caacagagtt acagttcgtt tttcact                                           27


<210> 1473
<211> 372
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region"

<400> 1473
gaggtgcagc tgttggagtc tgggggaggc gtggtccagc ctgggaggtc cctgagactc       60

tcctgtgcag cctctggatt caccttcagt gacttttcta tgcactgggt ccgccaggct      120

ccaggcaagg ggctggagtg ggtggcactc atctcaaatg atggaagcaa taaatattat      180

tcagactccc tgaagggttc attcatcatc tccagagaca actccaagaa cacgctctat      240

ctccaactga acagcctggg agctgaggac acggctctct attactgtgc gagagatgcg      300

gttccccatt atgattacgt ctggggaaac tttgactact ggggccaggg aaccctggtc      360

actgtctcct ca                                                          372


<210> 1474
<211> 124
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region"

<400> 1474
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp Phe 
            20                  25                  30          


Ser Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Leu Ile Ser Asn Asp Gly Ser Asn Lys Tyr Tyr Ser Asp Ser Leu 
    50                  55                  60                  


Lys Gly Ser Phe Ile Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Leu Asn Ser Leu Gly Ala Glu Asp Thr Ala Leu Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Ala Val Pro His Tyr Asp Tyr Val Trp Gly Asn Phe Asp 
            100                 105                 110         


Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 


<210> 1475
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H1"

<400> 1475
Phe Thr Phe Ser Asp Phe Ser Met His 
1               5                   


<210> 1476
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H1"

<400> 1476
ttcaccttca gtgacttttc tatgcac                                           27


<210> 1477
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H2"

<400> 1477
Leu Ile Ser Asn Asp Gly Ser Asn Lys Tyr Tyr Ser Asp Ser Leu Lys 
1               5                   10                  15      


Gly 
    


<210> 1478
<211> 51
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H2"

<400> 1478
ctcatctcaa atgatggaag caataaatat tattcagact ccctgaaggg t                51


<210> 1479
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H3"

<400> 1479
Ala Arg Asp Ala Val Pro His Tyr Asp Tyr Val Trp Gly Asn Phe Asp 
1               5                   10                  15      


Tyr 
    


<210> 1480
<211> 51
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H3"

<400> 1480
gcgagagatg cggttcccca ttatgattac gtctggggaa actttgacta c                51


<210> 1481
<211> 330
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region"

<400> 1481
cagtctgttc tgactcagcc tgcctccgtg tctgcgtctc ctggacagtc gatcaccatc       60

tcctgcactg gaaccagcag tgacgttggt ggttataatt atgtctcctg gtaccaacag      120

cacccaggca aagcccccaa actcataatt tatgaggtca gtaatcggcc ctcaggggtt      180

tctaatcgct tctctggctc caagtctggc aacacggcct ccctgaccat ctctgggctc      240

caggctgacg acgaggctga ttattactgc agctcatata caagtttcac tcccgtggta      300

ttcggcggag ggaccaagct gaccgtccta                                       330


<210> 1482
<211> 110
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region"

<400> 1482
Gln Ser Val Leu Thr Gln Pro Ala Ser Val Ser Ala Ser Pro Gly Gln 
1               5                   10                  15      


Ser Ile Thr Ile Ser Cys Thr Gly Thr Ser Ser Asp Val Gly Gly Tyr 
            20                  25                  30          


Asn Tyr Val Ser Trp Tyr Gln Gln His Pro Gly Lys Ala Pro Lys Leu 
        35                  40                  45              


Ile Ile Tyr Glu Val Ser Asn Arg Pro Ser Gly Val Ser Asn Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Asn Thr Ala Ser Leu Thr Ile Ser Gly Leu 
65                  70                  75                  80  


Gln Ala Asp Asp Glu Ala Asp Tyr Tyr Cys Ser Ser Tyr Thr Ser Phe 
                85                  90                  95      


Thr Pro Val Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 110 


<210> 1483
<211> 14
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L1"

<400> 1483
Thr Gly Thr Ser Ser Asp Val Gly Gly Tyr Asn Tyr Val Ser 
1               5                   10                  


<210> 1484
<211> 42
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L1"

<400> 1484
actggaacca gcagtgacgt tggtggttat aattatgtct cc                          42


<210> 1485
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L2"

<400> 1485
Glu Val Ser Asn Arg Pro Ser 
1               5           


<210> 1486
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L2"

<400> 1486
gaggtcagta atcggccctc a                                                 21


<210> 1487
<211> 10
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L3"

<400> 1487
Ser Ser Tyr Thr Ser Phe Thr Pro Val Val 
1               5                   10  


<210> 1488
<211> 30
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L3"

<400> 1488
agctcatata caagtttcac tcccgtggta                                        30


<210> 1489
<211> 360
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region"

<400> 1489
caggtccagc ttgtacagtc tggggcggag gtgaagaagc ctgggtcctc ggtgaaggtc       60

tcttgtaagt cttctggagg gaccttcagc aactatatta tcagctgggt gcgacaggcc      120

cctggacaag ggcttgagtg gatgggaggg atcgtccctc tctctggaac aacagactac      180

gcacagaagt tccagggccg agtcacgatt accgcggaca aatccacgac tacagcctac      240

atggagcttc gcaccttgag acctgaggac acggccgtct attattgtgc gagggggagt      300

ggtggtagca atgcctactt cgacccctgg ggccagggaa ccctggtcac cgtctcctca      360


<210> 1490
<211> 120
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region"

<400> 1490
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ser Ser Gly Gly Thr Phe Ser Asn Tyr 
            20                  25                  30          


Ile Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Gly Ile Val Pro Leu Ser Gly Thr Thr Asp Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Ala Asp Lys Ser Thr Thr Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Arg Thr Leu Arg Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Ser Gly Gly Ser Asn Ala Tyr Phe Asp Pro Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser 
        115                 120 


<210> 1491
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H1"

<400> 1491
Gly Thr Phe Ser Asn Tyr Ile Ile Ser 
1               5                   


<210> 1492
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H1"

<400> 1492
gggaccttca gcaactatat tatcagc                                           27


<210> 1493
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H2"

<400> 1493
Gly Ile Val Pro Leu Ser Gly Thr Thr Asp Tyr Ala Gln Lys Phe Gln 
1               5                   10                  15      


Gly 
    


<210> 1494
<211> 51
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H2"

<400> 1494
gggatcgtcc ctctctctgg aacaacagac tacgcacaga agttccaggg c                51


<210> 1495
<211> 13
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H3"

<400> 1495
Ala Arg Gly Ser Gly Gly Ser Asn Ala Tyr Phe Asp Pro 
1               5                   10              


<210> 1496
<211> 39
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H3"

<400> 1496
gcgaggggga gtggtggtag caatgcctac ttcgacccc                              39


<210> 1497
<211> 327
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region"

<400> 1497
cagtctgtgg tgacgcagcc gccctcagtg tcagtggccc caggaaagac ggccaagatt       60

acctgtgggg gaaacaacat tggaagtaag agtgtgtact ggtaccaaca gaagccaggc      120

caggcccctg tgctggtcat gtattatgat acttaccggc cctcagggat ccctgagcgc      180

ttctctggct ccaactctgg gaactcggcc accctgacca tcagcagagt cgacgccggg      240

gatgaggccg actattactg tcaggtgtgg gatagtagga gtgatcatcc ttatgtcttc      300

ggaagtggga ccaagctcac cgtccta                                          327


<210> 1498
<211> 109
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region"

<400> 1498
Gln Ser Val Val Thr Gln Pro Pro Ser Val Ser Val Ala Pro Gly Lys 
1               5                   10                  15      


Thr Ala Lys Ile Thr Cys Gly Gly Asn Asn Ile Gly Ser Lys Ser Val 
            20                  25                  30          


Tyr Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Val Leu Val Met Tyr 
        35                  40                  45              


Tyr Asp Thr Tyr Arg Pro Ser Gly Ile Pro Glu Arg Phe Ser Gly Ser 
    50                  55                  60                  


Asn Ser Gly Asn Ser Ala Thr Leu Thr Ile Ser Arg Val Asp Ala Gly 
65                  70                  75                  80  


Asp Glu Ala Asp Tyr Tyr Cys Gln Val Trp Asp Ser Arg Ser Asp His 
                85                  90                  95      


Pro Tyr Val Phe Gly Ser Gly Thr Lys Leu Thr Val Leu 
            100                 105                 


<210> 1499
<211> 11
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L1"

<400> 1499
Gly Gly Asn Asn Ile Gly Ser Lys Ser Val Tyr 
1               5                   10      


<210> 1500
<211> 33
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L1"

<400> 1500
gggggaaaca acattggaag taagagtgtg tac                                    33


<210> 1501
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L2"

<400> 1501
Tyr Asp Thr Tyr Arg Pro Ser 
1               5           


<210> 1502
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L2"

<400> 1502
tatgatactt accggccctc a                                                 21


<210> 1503
<211> 12
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L3"

<400> 1503
Gln Val Trp Asp Ser Arg Ser Asp His Pro Tyr Val 
1               5                   10          


<210> 1504
<211> 36
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L3"

<400> 1504
caggtgtggg atagtaggag tgatcatcct tatgtc                                 36


<210> 1505
<211> 384
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region"

<400> 1505
caggtccagc tggtgcagtc tggggctgag gtgaagaggc ctgggtcgtc ggtgaaggtc       60

tcctgcaagg cttctggagg cacgtccagc agttatatta tcagttgggt gcgacaggcc      120

cctgggcaag ggcttgagtg gatgggaggg atcatcccca tccctatttc tggcgcacca      180

acctacgcac agaagttcca gggcagagca aactatgcac agaagttcga gggcagactc      240

acgattaccg cggacagact cacgagcaca gcctacatgg agctgagcag cctgacatct      300

gaggacacgg ccgtgtatta ttgtgtaaga gatgagagga acgggggcta ttggggccag      360

ggaaccctgg tcaccgtctc ctca                                             384


<210> 1506
<211> 128
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region"

<400> 1506
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Arg Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Ser Ser Ser Tyr 
            20                  25                  30          


Ile Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Gly Ile Ile Pro Ile Pro Ile Ser Gly Ala Pro Thr Tyr Ala Gln 
    50                  55                  60                  


Lys Phe Gln Gly Arg Ala Asn Tyr Ala Gln Lys Phe Glu Gly Arg Leu 
65                  70                  75                  80  


Thr Ile Thr Ala Asp Arg Leu Thr Ser Thr Ala Tyr Met Glu Leu Ser 
                85                  90                  95      


Ser Leu Thr Ser Glu Asp Thr Ala Val Tyr Tyr Cys Val Arg Asp Glu 
            100                 105                 110         


Arg Asn Gly Gly Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125             


<210> 1507
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H1"

<400> 1507
Gly Thr Ser Ser Ser Tyr Ile Ile Ser 
1               5                   


<210> 1508
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H1"

<400> 1508
ggcacgtcca gcagttatat tatcagt                                           27


<210> 1509
<211> 29
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H2"

<400> 1509
Gly Ile Ile Pro Ile Pro Ile Ser Gly Ala Pro Thr Tyr Ala Gln Lys 
1               5                   10                  15      


Phe Gln Gly Arg Ala Asn Tyr Ala Gln Lys Phe Glu Gly 
            20                  25                  


<210> 1510
<211> 87
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H2"

<400> 1510
gggatcatcc ccatccctat ttctggcgca ccaacctacg cacagaagtt ccagggcaga       60

gcaaactatg cacagaagtt cgagggc                                           87


<210> 1511
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H3"

<400> 1511
Val Arg Asp Glu Arg Asn Gly Gly Tyr 
1               5                   


<210> 1512
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H3"

<400> 1512
gtaagagatg agaggaacgg gggctat                                           27


<210> 1513
<211> 330
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region"

<400> 1513
cagtctgccc tgactcagcc tgcctccgtg tctgggtctc ctggacagtc gatcaccatc       60

tcctgcactg gaaccagcaa tgacgttggt gcttataatc atgtgtcgtg gtaccaacaa      120

cacccaggga aagcccccaa actcatgatc tatgatgtca ctaatcggcc ctcaggggtt      180

tctaatcgct tctctggctc caagtctggc aacacggcct ccctgaccat ctttgggctc      240

cagactgacg acgaggctga ttattattgc agctcatata caatcagcag caccttggtg      300

ttcggcggag ggacccagct gaccgtcctc                                       330


<210> 1514
<211> 110
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region"

<400> 1514
Gln Ser Ala Leu Thr Gln Pro Ala Ser Val Ser Gly Ser Pro Gly Gln 
1               5                   10                  15      


Ser Ile Thr Ile Ser Cys Thr Gly Thr Ser Asn Asp Val Gly Ala Tyr 
            20                  25                  30          


Asn His Val Ser Trp Tyr Gln Gln His Pro Gly Lys Ala Pro Lys Leu 
        35                  40                  45              


Met Ile Tyr Asp Val Thr Asn Arg Pro Ser Gly Val Ser Asn Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Asn Thr Ala Ser Leu Thr Ile Phe Gly Leu 
65                  70                  75                  80  


Gln Thr Asp Asp Glu Ala Asp Tyr Tyr Cys Ser Ser Tyr Thr Ile Ser 
                85                  90                  95      


Ser Thr Leu Val Phe Gly Gly Gly Thr Gln Leu Thr Val Leu 
            100                 105                 110 


<210> 1515
<211> 14
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L1"

<400> 1515
Thr Gly Thr Ser Asn Asp Val Gly Ala Tyr Asn His Val Ser 
1               5                   10                  


<210> 1516
<211> 42
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L1"

<400> 1516
actggaacca gcaatgacgt tggtgcttat aatcatgtgt cg                          42


<210> 1517
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L2"

<400> 1517
Asp Val Thr Asn Arg Pro Ser 
1               5           


<210> 1518
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L2"

<400> 1518
gatgtcacta atcggccctc a                                                 21


<210> 1519
<211> 10
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L3"

<400> 1519
Ser Ser Tyr Thr Ile Ser Ser Thr Leu Val 
1               5                   10  


<210> 1520
<211> 30
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L3"

<400> 1520
agctcatata caatcagcag caccttggtg                                        30


<210> 1521
<211> 360
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region"

<400> 1521
gaggtgcagc tggtggagtc tgggggaggc gtggtccagc ctgggaggtc cctgaggctc       60

tcctgtgcag cctctggatt caccttcagt tcctatgcaa tgcactgggt ccgccaggct      120

ccaggcaagg gcctggagtg ggtggcagtt atatcatatg atgaaggcaa tgaatactac      180

gcagactccg tgaagggccg attcaccatc tccagagcca attccaagaa cacgatttat      240

ctgcaaatga acagcctgag agctgaggac acggctgtct attactgtgc gagagattac      300

atacatgggg actacggttt ggacgtctgg ggcctaggga ccacggtcac cgtctcctca      360


<210> 1522
<211> 120
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region"

<400> 1522
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Val Ile Ser Tyr Asp Glu Gly Asn Glu Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Ala Asn Ser Lys Asn Thr Ile Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Tyr Ile His Gly Asp Tyr Gly Leu Asp Val Trp Gly Leu 
            100                 105                 110         


Gly Thr Thr Val Thr Val Ser Ser 
        115                 120 


<210> 1523
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H1"

<400> 1523
Phe Thr Phe Ser Ser Tyr Ala Met His 
1               5                   


<210> 1524
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H1"

<400> 1524
ttcaccttca gttcctatgc aatgcac                                           27


<210> 1525
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H2"

<400> 1525
Val Ile Ser Tyr Asp Glu Gly Asn Glu Tyr Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210> 1526
<211> 51
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H2"

<400> 1526
gttatatcat atgatgaagg caatgaatac tacgcagact ccgtgaaggg c                51


<210> 1527
<211> 13
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H3"

<400> 1527
Ala Arg Asp Tyr Ile His Gly Asp Tyr Gly Leu Asp Val 
1               5                   10              


<210> 1528
<211> 39
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H3"

<400> 1528
gcgagagatt acatacatgg ggactacggt ttggacgtc                              39


<210> 1529
<211> 333
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region"

<400> 1529
gaaattgtgt tgacacagtc tccactctcc ctgcccgtca cccctggaga gccggcctcc       60

atctcctgca ggtctagtca gagcctcctg catagtaatg gatacaacta tttggattgg      120

tacctgcaga agccagggca gtctccacag ctcctgatct atttgggttc taatcgggcc      180

tccggggtcc ctgacaggtt cagtggcagt ggatcaggca cagattttac actgaaaatc      240

agcagagtgg aggctgagga tgttggggtt tactactgca tgcaacctct acaaacaatc      300

accttcggcc aagggacacg actggagatt aaa                                   333


<210> 1530
<211> 111
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region"

<400> 1530
Glu Ile Val Leu Thr Gln Ser Pro Leu Ser Leu Pro Val Thr Pro Gly 
1               5                   10                  15      


Glu Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Leu His Ser 
            20                  25                  30          


Asn Gly Tyr Asn Tyr Leu Asp Trp Tyr Leu Gln Lys Pro Gly Gln Ser 
        35                  40                  45              


Pro Gln Leu Leu Ile Tyr Leu Gly Ser Asn Arg Ala Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Met Gln Pro 
                85                  90                  95      


Leu Gln Thr Ile Thr Phe Gly Gln Gly Thr Arg Leu Glu Ile Lys 
            100                 105                 110     


<210> 1531
<211> 16
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L1"

<400> 1531
Arg Ser Ser Gln Ser Leu Leu His Ser Asn Gly Tyr Asn Tyr Leu Asp 
1               5                   10                  15      


<210> 1532
<211> 48
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L1"

<400> 1532
aggtctagtc agagcctcct gcatagtaat ggatacaact atttggat                    48


<210> 1533
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L2"

<400> 1533
Leu Gly Ser Asn Arg Ala Ser 
1               5           


<210> 1534
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L2"

<400> 1534
ttgggttcta atcgggcctc c                                                 21


<210> 1535
<211> 8
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L3"

<400> 1535
Met Gln Pro Leu Gln Thr Ile Thr 
1               5               


<210> 1536
<211> 24
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L3"

<400> 1536
atgcaacctc tacaaacaat cacc                                              24


<210> 1537
<211> 357
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region"

<400> 1537
caggtccagc tggtgcagtc tggggctgag gtgaagaagc ctggggcctc agtgaaggtc       60

tcctgcaagg cttctggata caccttcacc gactactata tgcactgggt gcgacaggcc      120

cctggacaag ggcttgagtg ggtgggatgg atcaacccta acagtggttc cacaaactat      180

gcacagaagt ttcagggcag ggtcaccgtg accagggaca cgtccatcag cacagcctac      240

atggacctga gcagactgag atctgacgac acggccgtgt attactgtgc gagcaggagc      300

tgggaccatg atgcttttga tatctggggc caagggacaa tggtcactgt ctcctca         357


<210> 1538
<211> 119
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region"

<400> 1538
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Tyr 
            20                  25                  30          


Tyr Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Val 
        35                  40                  45              


Gly Trp Ile Asn Pro Asn Ser Gly Ser Thr Asn Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Val Thr Arg Asp Thr Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Asp Leu Ser Arg Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ser Arg Ser Trp Asp His Asp Ala Phe Asp Ile Trp Gly Gln Gly 
            100                 105                 110         


Thr Met Val Thr Val Ser Ser 
        115                 


<210> 1539
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H1"

<400> 1539
Tyr Thr Phe Thr Asp Tyr Tyr Met His 
1               5                   


<210> 1540
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H1"

<400> 1540
tacaccttca ccgactacta tatgcac                                           27


<210> 1541
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H2"

<400> 1541
Trp Ile Asn Pro Asn Ser Gly Ser Thr Asn Tyr Ala Gln Lys Phe Gln 
1               5                   10                  15      


Gly 
    


<210> 1542
<211> 51
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H2"

<400> 1542
tggatcaacc ctaacagtgg ttccacaaac tatgcacaga agtttcaggg c                51


<210> 1543
<211> 12
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H3"

<400> 1543
Ala Ser Arg Ser Trp Asp His Asp Ala Phe Asp Ile 
1               5                   10          


<210> 1544
<211> 36
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H3"

<400> 1544
gcgagcagga gctgggacca tgatgctttt gatatc                                 36


<210> 1545
<211> 330
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region"

<400> 1545
cagtctgtct tgacgcagcc gccctcagtg tctggggccc cagggcagag ggtcaccatc       60

tcctgcactg ggagtagctc caacatcggg gcaggttatg atgtacactg gtaccagcag      120

cttccaggaa gagcccccaa actcctcatc tttggtaaca gcaatcggcc ctcaggggtc      180

cctgaccgat tctctggctc caagtctggc acctcagcct ccctggccat cactgggctc      240

cagcctgagg atgaggctga ttattactgc cactgctatg acagcaggct gagtgtggtc      300

ttcggcggag ggaccaagct caccgtccta                                       330


<210> 1546
<211> 110
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region"

<400> 1546
Gln Ser Val Leu Thr Gln Pro Pro Ser Val Ser Gly Ala Pro Gly Gln 
1               5                   10                  15      


Arg Val Thr Ile Ser Cys Thr Gly Ser Ser Ser Asn Ile Gly Ala Gly 
            20                  25                  30          


Tyr Asp Val His Trp Tyr Gln Gln Leu Pro Gly Arg Ala Pro Lys Leu 
        35                  40                  45              


Leu Ile Phe Gly Asn Ser Asn Arg Pro Ser Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Thr Gly Leu 
65                  70                  75                  80  


Gln Pro Glu Asp Glu Ala Asp Tyr Tyr Cys His Cys Tyr Asp Ser Arg 
                85                  90                  95      


Leu Ser Val Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 110 


<210> 1547
<211> 14
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L1"

<400> 1547
Thr Gly Ser Ser Ser Asn Ile Gly Ala Gly Tyr Asp Val His 
1               5                   10                  


<210> 1548
<211> 42
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L1"

<400> 1548
actgggagta gctccaacat cggggcaggt tatgatgtac ac                          42


<210> 1549
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L2"

<400> 1549
Gly Asn Ser Asn Arg Pro Ser 
1               5           


<210> 1550
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L2"

<400> 1550
ggtaacagca atcggccctc a                                                 21


<210> 1551
<211> 10
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L3"

<400> 1551
His Cys Tyr Asp Ser Arg Leu Ser Val Val 
1               5                   10  


<210> 1552
<211> 30
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L3"

<400> 1552
cactgctatg acagcaggct gagtgtggtc                                        30


<210> 1553
<211> 378
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region"

<400> 1553
caggtccagc tggtacagtc tgggactgag gtgaagaagc ctgggtcttc ggtgaaggtc       60

tcctgcaagg cttcgggagg caccttcagt agctatgcta tcagctgggt gcgacaggcc      120

cctggacaag ggcttgagtg gatgggaggg atccacccta cctctggtcc agcaaattac      180

gcacagaagt tccaggatag agtcaccatt accgtggaca agtccacgag cacagtctac      240

atggacctga gcagcctgag atctgaggac acggccgtgt attactgtgc gagagttggt      300

gtgggtcgca cttggatata tgatacaatg ggttaccttg acttctgggg ccagggaacc      360

ctggtcaccg tctcttca                                                    378


<210> 1554
<211> 126
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region"

<400> 1554
Gln Val Gln Leu Val Gln Ser Gly Thr Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Gly Ile His Pro Thr Ser Gly Pro Ala Asn Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Asp Arg Val Thr Ile Thr Val Asp Lys Ser Thr Ser Thr Val Tyr 
65                  70                  75                  80  


Met Asp Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Val Gly Val Gly Arg Thr Trp Ile Tyr Asp Thr Met Gly Tyr 
            100                 105                 110         


Leu Asp Phe Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125     


<210> 1555
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H1"

<400> 1555
Gly Thr Phe Ser Ser Tyr Ala Ile Ser 
1               5                   


<210> 1556
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H1"

<400> 1556
ggcaccttca gtagctatgc tatcagc                                           27


<210> 1557
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H2"

<400> 1557
Gly Ile His Pro Thr Ser Gly Pro Ala Asn Tyr Ala Gln Lys Phe Gln 
1               5                   10                  15      


Asp 
    


<210> 1558
<211> 51
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H2"

<400> 1558
gggatccacc ctacctctgg tccagcaaat tacgcacaga agttccagga t                51


<210> 1559
<211> 19
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H3"

<400> 1559
Ala Arg Val Gly Val Gly Arg Thr Trp Ile Tyr Asp Thr Met Gly Tyr 
1               5                   10                  15      


Leu Asp Phe 
            


<210> 1560
<211> 57
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H3"

<400> 1560
gcgagagttg gtgtgggtcg cacttggata tatgatacaa tgggttacct tgacttc          57


<210> 1561
<211> 324
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region"

<400> 1561
gaaattgtga tgacacagtc tccagccacg ctgtctttgt ctccaggaga aagagccacc       60

ctctcctgca gggccagtca gagtgttagc gactacttag cctggtacca acaaaaacct      120

ggccaggctc ccaggctcct catctatgat gcatccaaca gggccactgg catcccagcc      180

aggttcagtg gcagtgggtc tgggacagac ttcactctca ccatcaccag cctagagcct      240

gaagattttg cagtttatta ctgtcagcac cgtagcgact ggccttccct cactttcggc      300

ggagggacca agctggagat caaa                                             324


<210> 1562
<211> 108
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region"

<400> 1562
Glu Ile Val Met Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Asp Tyr 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 
        35                  40                  45              


Tyr Asp Ala Ser Asn Arg Ala Thr Gly Ile Pro Ala Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Thr Ser Leu Glu Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Val Tyr Tyr Cys Gln His Arg Ser Asp Trp Pro Ser 
                85                  90                  95      


Leu Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105             


<210> 1563
<211> 11
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L1"

<400> 1563
Arg Ala Ser Gln Ser Val Ser Asp Tyr Leu Ala 
1               5                   10      


<210> 1564
<211> 33
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L1"

<400> 1564
agggccagtc agagtgttag cgactactta gcc                                    33


<210> 1565
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L2"

<400> 1565
Asp Ala Ser Asn Arg Ala Thr 
1               5           


<210> 1566
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L2"

<400> 1566
gatgcatcca acagggccac t                                                 21


<210> 1567
<211> 10
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L3"

<400> 1567
Gln His Arg Ser Asp Trp Pro Ser Leu Thr 
1               5                   10  


<210> 1568
<211> 30
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L3"

<400> 1568
cagcaccgta gcgactggcc ttccctcact                                        30


<210> 1569
<211> 366
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region"

<400> 1569
gaggtgcagc tggtggagtc tgggggaggc ttggtacagc ctggcaggtc cctgagactc       60

tcctgtgtaa cttcgggatt cggctttgat gactatgcca tgcactgggt ccggcaagcc      120

ccagggaagg gcctggagtg ggtctcaggg attggttgga atagtggtgg cataggctat      180

gcggactctg tgaagggccg attctccatc tccagagaca acgccaagaa ctccttgtat      240

ctacaaatga acagtctgag acctgaagac actgccttct attactgtgt aaaagatggg      300

acccctatag cagtggctgg atactttgaa tactggggcc agggaaccct ggtcaccgtc      360

tcctca                                                                 366


<210> 1570
<211> 122
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region"

<400> 1570
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Val Thr Ser Gly Phe Gly Phe Asp Asp Tyr 
            20                  25                  30          


Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Gly Ile Gly Trp Asn Ser Gly Gly Ile Gly Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Ser Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Phe Tyr Tyr Cys 
                85                  90                  95      


Val Lys Asp Gly Thr Pro Ile Ala Val Ala Gly Tyr Phe Glu Tyr Trp 
            100                 105                 110         


Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120         


<210> 1571
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H1"

<400> 1571
Phe Gly Phe Asp Asp Tyr Ala Met His 
1               5                   


<210> 1572
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H1"

<400> 1572
ttcggctttg atgactatgc catgcac                                           27


<210> 1573
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H2"

<400> 1573
Gly Ile Gly Trp Asn Ser Gly Gly Ile Gly Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210> 1574
<211> 51
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H2"

<400> 1574
gggattggtt ggaatagtgg tggcataggc tatgcggact ctgtgaaggg c                51


<210> 1575
<211> 15
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H3"

<400> 1575
Val Lys Asp Gly Thr Pro Ile Ala Val Ala Gly Tyr Phe Glu Tyr 
1               5                   10                  15  


<210> 1576
<211> 45
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H3"

<400> 1576
gtaaaagatg ggacccctat agcagtggct ggatactttg aatac                       45


<210> 1577
<211> 330
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region"

<400> 1577
tcctatgagc tgacacagcc gccctcagcg tctggtaccc ccgggcagag ggtcaccatc       60

tcttgttctg gaggcaggtc caacatcgga aataattatg tatactggta ccagcagctc      120

ccaggaacgg cccccaaact cctcatctat aggcatgatc agcggccctc aggggtccct      180

gaccgattct ctggctccaa gtctggcacc tcagcctccc tggccatcaa tgggctccgg      240

tccgaggatg aggctgacta tttttgcgca gtatgggatg acagcctgag ttgttatgtc      300

ttcggagctg ggaccaagct caccgtccta                                       330


<210> 1578
<211> 110
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region"

<400> 1578
Ser Tyr Glu Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln 
1               5                   10                  15      


Arg Val Thr Ile Ser Cys Ser Gly Gly Arg Ser Asn Ile Gly Asn Asn 
            20                  25                  30          


Tyr Val Tyr Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 
        35                  40                  45              


Ile Tyr Arg His Asp Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Asn Gly Leu Arg 
65                  70                  75                  80  


Ser Glu Asp Glu Ala Asp Tyr Phe Cys Ala Val Trp Asp Asp Ser Leu 
                85                  90                  95      


Ser Cys Tyr Val Phe Gly Ala Gly Thr Lys Leu Thr Val Leu 
            100                 105                 110 


<210> 1579
<211> 13
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L1"

<400> 1579
Ser Gly Gly Arg Ser Asn Ile Gly Asn Asn Tyr Val Tyr 
1               5                   10              


<210> 1580
<211> 39
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L1"

<400> 1580
tctggaggca ggtccaacat cggaaataat tatgtatac                              39


<210> 1581
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L2"

<400> 1581
Arg His Asp Gln Arg Pro Ser 
1               5           


<210> 1582
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L2"

<400> 1582
aggcatgatc agcggccctc a                                                 21


<210> 1583
<211> 11
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L3"

<400> 1583
Ala Val Trp Asp Asp Ser Leu Ser Cys Tyr Val 
1               5                   10      


<210> 1584
<211> 33
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L3"

<400> 1584
gcagtatggg atgacagcct gagttgttat gtc                                    33


<210> 1585
<211> 369
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region"

<400> 1585
caggtccagc tggtgcagtc tggggctgag gtgaagaagc ctgggtcctc ggtgaaggtc       60

tcctgcaagg cctctggagg caccttcagc acctatggta tcagctgggt gcgacaggcc      120

cctggacaag gtcttgagtg gatgggaagg gtcatcccta tgtttggaac agcaacctac      180

gcacagaagt tccaggacag agtcacgatt accgcggaca aagccacgag cacggcgtac      240

atggagctga acagcctgag atctgacgac acggccgtat attactgtgc gagatgtcct      300

ccttttgagg gagttcgtcc gccctggttc gacccctggg gccagggaac cctggtcacc      360

gtctcttca                                                              369


<210> 1586
<211> 123
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region"

<400> 1586
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Thr Tyr 
            20                  25                  30          


Gly Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Arg Val Ile Pro Met Phe Gly Thr Ala Thr Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Asp Arg Val Thr Ile Thr Ala Asp Lys Ala Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Asn Ser Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Cys Pro Pro Phe Glu Gly Val Arg Pro Pro Trp Phe Asp Pro 
            100                 105                 110         


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120             


<210> 1587
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H1"

<400> 1587
Gly Thr Phe Ser Thr Tyr Gly Ile Ser 
1               5                   


<210> 1588
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H1"

<400> 1588
ggcaccttca gcacctatgg tatcagc                                           27


<210> 1589
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H2"

<400> 1589
Arg Val Ile Pro Met Phe Gly Thr Ala Thr Tyr Ala Gln Lys Phe Gln 
1               5                   10                  15      


Asp 
    


<210> 1590
<211> 51
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H2"

<400> 1590
agggtcatcc ctatgtttgg aacagcaacc tacgcacaga agttccagga c                51


<210> 1591
<211> 16
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H3"

<400> 1591
Ala Arg Cys Pro Pro Phe Glu Gly Val Arg Pro Pro Trp Phe Asp Pro 
1               5                   10                  15      


<210> 1592
<211> 48
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H3"

<400> 1592
gcgagatgtc ctccttttga gggagttcgt ccgccctggt tcgacccc                    48


<210> 1593
<211> 324
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region"

<400> 1593
tcctatgagc tgactcagcc accctcggtg tcagtggccc caggacggac ggccaagatt       60

acctgtgggg gatacaacat tggaaataaa cgtgtgcact ggtaccggca gaggccaggc      120

caggccccag tgctgatcgt ctatgataat gccgaccggc cctcagggat ccctgagcga      180

ttctctggct ccaactctgg gaacacggcc accctgacca tcagcaacgt cgcagccggg      240

gatgaggccg actatcactg tcaggtgtgg gaaactagta gtgatcatcc ggtattcggc      300

ggagggacca agctcaccgt ccta                                             324


<210> 1594
<211> 108
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region"

<400> 1594
Ser Tyr Glu Leu Thr Gln Pro Pro Ser Val Ser Val Ala Pro Gly Arg 
1               5                   10                  15      


Thr Ala Lys Ile Thr Cys Gly Gly Tyr Asn Ile Gly Asn Lys Arg Val 
            20                  25                  30          


His Trp Tyr Arg Gln Arg Pro Gly Gln Ala Pro Val Leu Ile Val Tyr 
        35                  40                  45              


Asp Asn Ala Asp Arg Pro Ser Gly Ile Pro Glu Arg Phe Ser Gly Ser 
    50                  55                  60                  


Asn Ser Gly Asn Thr Ala Thr Leu Thr Ile Ser Asn Val Ala Ala Gly 
65                  70                  75                  80  


Asp Glu Ala Asp Tyr His Cys Gln Val Trp Glu Thr Ser Ser Asp His 
                85                  90                  95      


Pro Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105             


<210> 1595
<211> 11
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L1"

<400> 1595
Gly Gly Tyr Asn Ile Gly Asn Lys Arg Val His 
1               5                   10      


<210> 1596
<211> 33
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L1"

<400> 1596
gggggataca acattggaaa taaacgtgtg cac                                    33


<210> 1597
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L2"

<400> 1597
Asp Asn Ala Asp Arg Pro Ser 
1               5           


<210> 1598
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L2"

<400> 1598
gataatgccg accggccctc a                                                 21


<210> 1599
<211> 11
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L3"

<400> 1599
Gln Val Trp Glu Thr Ser Ser Asp His Pro Val 
1               5                   10      


<210> 1600
<211> 33
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L3"

<400> 1600
caggtgtggg aaactagtag tgatcatccg gta                                    33


<210> 1601
<211> 354
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region"

<400> 1601
gaggtgcagc tggtgcagtc tggaacagag gtgaaaaagc ccggggaatc tctgaagatc       60

tcttgtaagg cttctggata cagctctttc cccaattgga tcggctgggt gcgccagatg      120

cccgggaaag gcctggagta catggggtcc atctttcctg atgactctaa taccagatat      180

agtccgtcct tccgaggcct ggtcgccatc tcagccgaca agtccctgag aaccgcctat      240

ctgcagtgga gcagcctgaa ggcctcggac agcgccatat attactgtgc gagagggccc      300

ttcccgcact actttgactc ctggggtcag ggaaccctgg tcaccgtctc ctca            354


<210> 1602
<211> 118
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region"

<400> 1602
Glu Val Gln Leu Val Gln Ser Gly Thr Glu Val Lys Lys Pro Gly Glu 
1               5                   10                  15      


Ser Leu Lys Ile Ser Cys Lys Ala Ser Gly Tyr Ser Ser Phe Pro Asn 
            20                  25                  30          


Trp Ile Gly Trp Val Arg Gln Met Pro Gly Lys Gly Leu Glu Tyr Met 
        35                  40                  45              


Gly Ser Ile Phe Pro Asp Asp Ser Asn Thr Arg Tyr Ser Pro Ser Phe 
    50                  55                  60                  


Arg Gly Leu Val Ala Ile Ser Ala Asp Lys Ser Leu Arg Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Trp Ser Ser Leu Lys Ala Ser Asp Ser Ala Ile Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Pro Phe Pro His Tyr Phe Asp Ser Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser 
        115             


<210> 1603
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H1"

<400> 1603
Tyr Ser Ser Phe Pro Asn Trp Ile Gly 
1               5                   


<210> 1604
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H1"

<400> 1604
tacagctctt tccccaattg gatcggc                                           27


<210> 1605
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H2"

<400> 1605
Ser Ile Phe Pro Asp Asp Ser Asn Thr Arg Tyr Ser Pro Ser Phe Arg 
1               5                   10                  15      


Gly 
    


<210> 1606
<211> 51
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H2"

<400> 1606
tccatctttc ctgatgactc taataccaga tatagtccgt ccttccgagg c                51


<210> 1607
<211> 11
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H3"

<400> 1607
Ala Arg Gly Pro Phe Pro His Tyr Phe Asp Ser 
1               5                   10      


<210> 1608
<211> 33
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H3"

<400> 1608
gcgagagggc ccttcccgca ctactttgac tcc                                    33


<210> 1609
<211> 333
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region"

<400> 1609
aattttatgc tgactcagcc ccactctgtg tcggagtctc cggggaagac ggtcaccatc       60

tcctgcaccc gcagcagtgg cagtattgcc cgcaactatg tgcagtggta ccagcagcgc      120

ccgggcagtt cccccaccac tgtgatctat gaggatgacc aaagaccccc tggggtccct      180

gatcggttct ctggctccat cgacagctcc tccaactctg cctccctcac catctctgga      240

ctgcagactg aggacgaggc tgactactac tgtcagtctt atgatcccac caatcaaaat      300

gtcttcggaa ctgggaccaa gctcaccgtc cta                                   333


<210> 1610
<211> 111
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region"

<400> 1610
Asn Phe Met Leu Thr Gln Pro His Ser Val Ser Glu Ser Pro Gly Lys 
1               5                   10                  15      


Thr Val Thr Ile Ser Cys Thr Arg Ser Ser Gly Ser Ile Ala Arg Asn 
            20                  25                  30          


Tyr Val Gln Trp Tyr Gln Gln Arg Pro Gly Ser Ser Pro Thr Thr Val 
        35                  40                  45              


Ile Tyr Glu Asp Asp Gln Arg Pro Pro Gly Val Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Ile Asp Ser Ser Ser Asn Ser Ala Ser Leu Thr Ile Ser Gly 
65                  70                  75                  80  


Leu Gln Thr Glu Asp Glu Ala Asp Tyr Tyr Cys Gln Ser Tyr Asp Pro 
                85                  90                  95      


Thr Asn Gln Asn Val Phe Gly Thr Gly Thr Lys Leu Thr Val Leu 
            100                 105                 110     


<210> 1611
<211> 13
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L1"

<400> 1611
Thr Arg Ser Ser Gly Ser Ile Ala Arg Asn Tyr Val Gln 
1               5                   10              


<210> 1612
<211> 39
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L1"

<400> 1612
acccgcagca gtggcagtat tgcccgcaac tatgtgcag                              39


<210> 1613
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L2"

<400> 1613
Glu Asp Asp Gln Arg Pro Pro 
1               5           


<210> 1614
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L2"

<400> 1614
gaggatgacc aaagaccccc t                                                 21


<210> 1615
<211> 10
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L3"

<400> 1615
Gln Ser Tyr Asp Pro Thr Asn Gln Asn Val 
1               5                   10  


<210> 1616
<211> 30
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L3"

<400> 1616
cagtcttatg atcccaccaa tcaaaatgtc                                        30


<210> 1617
<211> 363
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region"

<400> 1617
gaggtgcagc tggtggagtc tgggggaggc gtggtccagc ctgggaggtc cctgagactc       60

tcctgtgaag cctctggatt caacttccat aattatgata tacaatgggt ccgccaggcc      120

ccaggcaagg ggctggagtg ggtggcacta gtattatttg atggaagcaa aaaatattat      180

ccacactctg tgaagggccg attcgccatc tccagagaca actccaaaaa aactctattt      240

ctgcaaatga acagcctgag acctgaggac acggctgtgt attactgtgc gagagcccca      300

gtgactggcg cctcgtatta ccttgactat tggggccagg gaaccctggt caccgtctcc      360

tca                                                                    363


<210> 1618
<211> 121
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region"

<400> 1618
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Glu Ala Ser Gly Phe Asn Phe His Asn Tyr 
            20                  25                  30          


Asp Ile Gln Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Leu Val Leu Phe Asp Gly Ser Lys Lys Tyr Tyr Pro His Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Ala Ile Ser Arg Asp Asn Ser Lys Lys Thr Leu Phe 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ala Pro Val Thr Gly Ala Ser Tyr Tyr Leu Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120     


<210> 1619
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H1"

<400> 1619
Phe Asn Phe His Asn Tyr Asp Ile Gln 
1               5                   


<210> 1620
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H1"

<400> 1620
ttcaacttcc ataattatga tatacaa                                           27


<210> 1621
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H2"

<400> 1621
Leu Val Leu Phe Asp Gly Ser Lys Lys Tyr Tyr Pro His Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210> 1622
<211> 51
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H2"

<400> 1622
ctagtattat ttgatggaag caaaaaatat tatccacact ctgtgaaggg c                51


<210> 1623
<211> 14
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H3"

<400> 1623
Ala Arg Ala Pro Val Thr Gly Ala Ser Tyr Tyr Leu Asp Tyr 
1               5                   10                  


<210> 1624
<211> 42
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H3"

<400> 1624
gcgagagccc cagtgactgg cgcctcgtat taccttgact at                          42


<210> 1625
<211> 324
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region"

<400> 1625
tcctatgtgc tgacacagcc accctcggtg tcagtggccc caggacagac ggccagaatt       60

acctgtgggg caaacaacat tggaaataaa ggtgtgcact ggtaccaaca gaagccaggc      120

caggcccctg tgctggtcgt ctatgatgat gacgaccagc cctcagggat ccctgagcga      180

ttctctggct ccaactctgg gaacacggcc accctgacca tcagcagggt cgaagccggg      240

gatgaggccg actattactg tcaggtgtgg gatagtacta gtgatcatct ggtattcggc      300

ggagggaccc agctgaccgt ccta                                             324


<210> 1626
<211> 108
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region"

<400> 1626
Ser Tyr Val Leu Thr Gln Pro Pro Ser Val Ser Val Ala Pro Gly Gln 
1               5                   10                  15      


Thr Ala Arg Ile Thr Cys Gly Ala Asn Asn Ile Gly Asn Lys Gly Val 
            20                  25                  30          


His Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Val Leu Val Val Tyr 
        35                  40                  45              


Asp Asp Asp Asp Gln Pro Ser Gly Ile Pro Glu Arg Phe Ser Gly Ser 
    50                  55                  60                  


Asn Ser Gly Asn Thr Ala Thr Leu Thr Ile Ser Arg Val Glu Ala Gly 
65                  70                  75                  80  


Asp Glu Ala Asp Tyr Tyr Cys Gln Val Trp Asp Ser Thr Ser Asp His 
                85                  90                  95      


Leu Val Phe Gly Gly Gly Thr Gln Leu Thr Val Leu 
            100                 105             


<210> 1627
<211> 11
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L1"

<400> 1627
Gly Ala Asn Asn Ile Gly Asn Lys Gly Val His 
1               5                   10      


<210> 1628
<211> 33
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L1"

<400> 1628
ggggcaaaca acattggaaa taaaggtgtg cac                                    33


<210> 1629
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L2"

<400> 1629
Asp Asp Asp Asp Gln Pro Ser 
1               5           


<210> 1630
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L2"

<400> 1630
gatgatgacg accagccctc a                                                 21


<210> 1631
<211> 11
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L3"

<400> 1631
Gln Val Trp Asp Ser Thr Ser Asp His Leu Val 
1               5                   10      


<210> 1632
<211> 33
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L3"

<400> 1632
caggtgtggg atagtactag tgatcatctg gta                                    33


<210> 1633
<211> 375
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region"

<400> 1633
caggtgcagc tgcaggagtc gggcccagga ctggtgaagc cttcggagac cctgtccctc       60

acctgcactg tctctggtgg ctccgtcagc agagggagtt actactggac ctggatccgg      120

cagcccccag ggaagggact ggagtggatt ggctatatct attacagtgg gagcaccaac      180

tacaacccct ccctcaagag tcgagtcacc atatcagtag acacgtccaa gaaccagttc      240

tccctgaagc tgagctctgt gaccgctgcg gacacggccg tttattactg tgcgagagat      300

ataggggaag ataagtatgg tacttactac ggtatggacg tctggggcca agggaccacg      360

gtcaccgtct cttca                                                       375


<210> 1634
<211> 125
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region"

<400> 1634
Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Gly Ser Val Ser Arg Gly 
            20                  25                  30          


Ser Tyr Tyr Trp Thr Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu 
        35                  40                  45              


Trp Ile Gly Tyr Ile Tyr Tyr Ser Gly Ser Thr Asn Tyr Asn Pro Ser 
    50                  55                  60                  


Leu Lys Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe 
65                  70                  75                  80  


Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr 
                85                  90                  95      


Cys Ala Arg Asp Ile Gly Glu Asp Lys Tyr Gly Thr Tyr Tyr Gly Met 
            100                 105                 110         


Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120                 125 


<210> 1635
<211> 11
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H1"

<400> 1635
Gly Ser Val Ser Arg Gly Ser Tyr Tyr Trp Thr 
1               5                   10      


<210> 1636
<211> 33
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H1"

<400> 1636
ggctccgtca gcagagggag ttactactgg acc                                    33


<210> 1637
<211> 16
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H2"

<400> 1637
Tyr Ile Tyr Tyr Ser Gly Ser Thr Asn Tyr Asn Pro Ser Leu Lys Ser 
1               5                   10                  15      


<210> 1638
<211> 48
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H2"

<400> 1638
tatatctatt acagtgggag caccaactac aacccctccc tcaagagt                    48


<210> 1639
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H3"

<400> 1639
Ala Arg Asp Ile Gly Glu Asp Lys Tyr Gly Thr Tyr Tyr Gly Met Asp 
1               5                   10                  15      


Val 
    


<210> 1640
<211> 51
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H3"

<400> 1640
gcgagagata taggggaaga taagtatggt acttactacg gtatggacgt c                51


<210> 1641
<211> 324
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region"

<400> 1641
gaaattgtga tgacacagtc tccagccacc ctgtctttgt ctccaggaga aagagccacc       60

ctctcctgca gggccagtca gagtgttagc agctccttag cctggtacca acagaaacct      120

ggccaggctc ccaggctcct catctatggt gcatccaaca gggccactgg catcccagcc      180

aggttcagtg gcagtgggtc tgggacagac ttcactctca ccatcagtag cctagagcct      240

gaggattttg cagtttatta ctgtcagcag cgtaccaact ggcccccggt cactttcggc      300

cctgggacca aggtggaaat caaa                                             324


<210> 1642
<211> 108
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region"

<400> 1642
Glu Ile Val Met Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Ser 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 
        35                  40                  45              


Tyr Gly Ala Ser Asn Arg Ala Thr Gly Ile Pro Ala Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Arg Thr Asn Trp Pro Pro 
                85                  90                  95      


Val Thr Phe Gly Pro Gly Thr Lys Val Glu Ile Lys 
            100                 105             


<210> 1643
<211> 11
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L1"

<400> 1643
Arg Ala Ser Gln Ser Val Ser Ser Ser Leu Ala 
1               5                   10      


<210> 1644
<211> 33
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L1"

<400> 1644
agggccagtc agagtgttag cagctcctta gcc                                    33


<210> 1645
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L2"

<400> 1645
Gly Ala Ser Asn Arg Ala Thr 
1               5           


<210> 1646
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L2"

<400> 1646
ggtgcatcca acagggccac t                                                 21


<210> 1647
<211> 10
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L3"

<400> 1647
Gln Gln Arg Thr Asn Trp Pro Pro Val Thr 
1               5                   10  


<210> 1648
<211> 30
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L3"

<400> 1648
cagcagcgta ccaactggcc cccggtcact                                        30


<210> 1649
<211> 366
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region"

<400> 1649
caggtccagc tggtacagtc tgggggaggc ctggtcaagc ctggggggtc cctgagactc       60

tcttgtgcag cctctggatt caccttcagt agctatacca tgaactgggt ccgccaggct      120

ccagggaagg ggctggagtg ggtctcatcc attactggtg gtagtagttt cacaaactac      180

gcagactcac tggagggccg attcaccatc tccagagata acgccaagag ctcacttttt      240

ctgcaaatga acagcctgag agtcgaggac acggctgtat attactgtgc gagagatcag      300

ccggggacga tttttggagt ggtccaggac tactggggcc agggaaccct ggtcaccgtc      360

tcctca                                                                 366


<210> 1650
<211> 122
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region"

<400> 1650
Gln Val Gln Leu Val Gln Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Thr Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ser Ile Thr Gly Gly Ser Ser Phe Thr Asn Tyr Ala Asp Ser Leu 
    50                  55                  60                  


Glu Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Ser Ser Leu Phe 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Val Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Gln Pro Gly Thr Ile Phe Gly Val Val Gln Asp Tyr Trp 
            100                 105                 110         


Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120         


<210> 1651
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H1"

<400> 1651
Phe Thr Phe Ser Ser Tyr Thr Met Asn 
1               5                   


<210> 1652
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H1"

<400> 1652
ttcaccttca gtagctatac catgaac                                           27


<210> 1653
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H2"

<400> 1653
Ser Ile Thr Gly Gly Ser Ser Phe Thr Asn Tyr Ala Asp Ser Leu Glu 
1               5                   10                  15      


Gly 
    


<210> 1654
<211> 51
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H2"

<400> 1654
tccattactg gtggtagtag tttcacaaac tacgcagact cactggaggg c                51


<210> 1655
<211> 15
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H3"

<400> 1655
Ala Arg Asp Gln Pro Gly Thr Ile Phe Gly Val Val Gln Asp Tyr 
1               5                   10                  15  


<210> 1656
<211> 45
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H3"

<400> 1656
gcgagagatc agccggggac gatttttgga gtggtccagg actac                       45


<210> 1657
<211> 330
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region"

<400> 1657
cagtctgtct tgacgcagcc gccctcagtg tctggggccc cagggcagag ggtcaccatc       60

tcctgcactg ggggcagctc caacatcggg gcaggttatg atgtgcactg gtaccagcag      120

cttccaggaa cagcccccaa actcctcatc tatggtaaca gcaatcggcc ctcaggggtc      180

cctgaccgat tctctggctc caagtctggc acctcagcct ccctggccat cactgggctc      240

caggctgagg atgaggctga ttattactgc cagtcctatg acagccgcct gagtgtggta      300

ttcggcggag ggaccaaggt gaccgtccta                                       330


<210> 1658
<211> 110
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region"

<400> 1658
Gln Ser Val Leu Thr Gln Pro Pro Ser Val Ser Gly Ala Pro Gly Gln 
1               5                   10                  15      


Arg Val Thr Ile Ser Cys Thr Gly Gly Ser Ser Asn Ile Gly Ala Gly 
            20                  25                  30          


Tyr Asp Val His Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu 
        35                  40                  45              


Leu Ile Tyr Gly Asn Ser Asn Arg Pro Ser Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Thr Gly Leu 
65                  70                  75                  80  


Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Gln Ser Tyr Asp Ser Arg 
                85                  90                  95      


Leu Ser Val Val Phe Gly Gly Gly Thr Lys Val Thr Val Leu 
            100                 105                 110 


<210> 1659
<211> 14
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L1"

<400> 1659
Thr Gly Gly Ser Ser Asn Ile Gly Ala Gly Tyr Asp Val His 
1               5                   10                  


<210> 1660
<211> 42
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L1"

<400> 1660
actgggggca gctccaacat cggggcaggt tatgatgtgc ac                          42


<210> 1661
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L2"

<400> 1661
Gly Asn Ser Asn Arg Pro Ser 
1               5           


<210> 1662
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L2"

<400> 1662
ggtaacagca atcggccctc a                                                 21


<210> 1663
<211> 10
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L3"

<400> 1663
Gln Ser Tyr Asp Ser Arg Leu Ser Val Val 
1               5                   10  


<210> 1664
<211> 30
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L3"

<400> 1664
cagtcctatg acagccgcct gagtgtggta                                        30


<210> 1665
<211> 366
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region"

<400> 1665
gaggtgcagc tggtggagtc tggggctgag gtgaagaagc ctgggtcctc ggtgaaggtc       60

tcctgcaagg cttctggagg caccttcagc agctatgcta tcagctgggt gcgacaggcc      120

cctggacaag gacttgagtg gatgggaggg accatcccta tttttggtac aatcaactac      180

gcacagaagt tccagggcag actcacgatt aacgcggacg catcaacgag cacagcctac      240

atggagctga gcagcctgag atctgaggac acggccgtgt atttctgtgc gagagaccgg      300

actacagctg tgaggtacta cgctatggac gtctggggcc aagggaccac ggtcaccgtc      360

tcttca                                                                 366


<210> 1666
<211> 122
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region"

<400> 1666
Glu Val Gln Leu Val Glu Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Gly Thr Ile Pro Ile Phe Gly Thr Ile Asn Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Leu Thr Ile Asn Ala Asp Ala Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Phe Cys 
                85                  90                  95      


Ala Arg Asp Arg Thr Thr Ala Val Arg Tyr Tyr Ala Met Asp Val Trp 
            100                 105                 110         


Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120         


<210> 1667
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H1"

<400> 1667
Gly Thr Phe Ser Ser Tyr Ala Ile Ser 
1               5                   


<210> 1668
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H1"

<400> 1668
ggcaccttca gcagctatgc tatcagc                                           27


<210> 1669
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H2"

<400> 1669
Gly Thr Ile Pro Ile Phe Gly Thr Ile Asn Tyr Ala Gln Lys Phe Gln 
1               5                   10                  15      


Gly 
    


<210> 1670
<211> 51
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H2"

<400> 1670
gggaccatcc ctatttttgg tacaatcaac tacgcacaga agttccaggg c                51


<210> 1671
<211> 15
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H3"

<400> 1671
Ala Arg Asp Arg Thr Thr Ala Val Arg Tyr Tyr Ala Met Asp Val 
1               5                   10                  15  


<210> 1672
<211> 45
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H3"

<400> 1672
gcgagagacc ggactacagc tgtgaggtac tacgctatgg acgtc                       45


<210> 1673
<211> 324
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region"

<400> 1673
gaaattgtgt tgacacagtc tccagccacc ctgtctttgt ctccagggga aagagccacc       60

ctctcctgca gggccagtca gagtgttagc agctacttag cctggtacca acagaaacct      120

ggccaggctc ccaggctcct catctatgat acatccaaca gggccactga catcccagcc      180

aggttcagtg gcagtgggtc tgggacagac ttcactctca ccatcagcag cctagagcct      240

gaagattttg cagtttatta ctgtcagcac cgtgccaact ggcccccgct cactttcggc      300

ggagggacca aggtggaaat caaa                                             324


<210> 1674
<211> 108
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region"

<400> 1674
Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Tyr 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 
        35                  40                  45              


Tyr Asp Thr Ser Asn Arg Ala Thr Asp Ile Pro Ala Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Val Tyr Tyr Cys Gln His Arg Ala Asn Trp Pro Pro 
                85                  90                  95      


Leu Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105             


<210> 1675
<211> 11
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L1"

<400> 1675
Arg Ala Ser Gln Ser Val Ser Ser Tyr Leu Ala 
1               5                   10      


<210> 1676
<211> 33
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L1"

<400> 1676
agggccagtc agagtgttag cagctactta gcc                                    33


<210> 1677
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L2"

<400> 1677
Asp Thr Ser Asn Arg Ala Thr 
1               5           


<210> 1678
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L2"

<400> 1678
gatacatcca acagggccac t                                                 21


<210> 1679
<211> 10
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L3"

<400> 1679
Gln His Arg Ala Asn Trp Pro Pro Leu Thr 
1               5                   10  


<210> 1680
<211> 30
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L3"

<400> 1680
cagcaccgtg ccaactggcc cccgctcact                                        30


<210> 1681
<211> 378
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region"

<400> 1681
caggtccagc ttgtgcagtc tgggcctgag gtgaagaggc ctgggtcctc ggtgaaggtc       60

tcctgcaagg cttctggaga caccttcaac aactacgcca tcagctgggt gcgacaggcc      120

cctggacaag gacttgagtg gatgggaggg atccacccta ccactgctac accaaactac      180

gcacagaagt tccagggcag agtcgtcatt agcgcggaca agtccacgag tacagcctac      240

ttggacctga gtcggctgag atctgaggac acggccatgt attactgtgc gagagttggt      300

gtgggacgca cttgggtcta tgatattatg ggttacctag actactgggg ccagggaacc      360

ctggtcaccg tctcctca                                                    378


<210> 1682
<211> 126
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region"

<400> 1682
Gln Val Gln Leu Val Gln Ser Gly Pro Glu Val Lys Arg Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Asp Thr Phe Asn Asn Tyr 
            20                  25                  30          


Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Gly Ile His Pro Thr Thr Ala Thr Pro Asn Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Val Ile Ser Ala Asp Lys Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Leu Asp Leu Ser Arg Leu Arg Ser Glu Asp Thr Ala Met Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Val Gly Val Gly Arg Thr Trp Val Tyr Asp Ile Met Gly Tyr 
            100                 105                 110         


Leu Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125     


<210> 1683
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H1"

<400> 1683
Asp Thr Phe Asn Asn Tyr Ala Ile Ser 
1               5                   


<210> 1684
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H1"

<400> 1684
gacaccttca acaactacgc catcagc                                           27


<210> 1685
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H2"

<400> 1685
Gly Ile His Pro Thr Thr Ala Thr Pro Asn Tyr Ala Gln Lys Phe Gln 
1               5                   10                  15      


Gly 
    


<210> 1686
<211> 51
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H2"

<400> 1686
gggatccacc ctaccactgc tacaccaaac tacgcacaga agttccaggg c                51


<210> 1687
<211> 19
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H3"

<400> 1687
Ala Arg Val Gly Val Gly Arg Thr Trp Val Tyr Asp Ile Met Gly Tyr 
1               5                   10                  15      


Leu Asp Tyr 
            


<210> 1688
<211> 57
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H3"

<400> 1688
gcgagagttg gtgtgggacg cacttgggtc tatgatatta tgggttacct agactac          57


<210> 1689
<211> 324
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region"

<400> 1689
gaaattgtat tgacacagtc tccagccacc ctgtctttgt ctccagggga aagagccacc       60

ctctcctgca gggccagtca gagtgttagc gactacttgg cctggtacca acaaagacct      120

ggccaggctc ccaggctcct catctatgat gcgtccacca gggccactgg catcccagac      180

aggttcagtg gcggtgggtc tgggacagac ttcactctca ccatcagcag cctagagcct      240

gaagattttg cagtttatta ctgtcaacac cgtaacaact ggccttccct cactttcggc      300

ggagggacca aggtggaaat caaa                                             324


<210> 1690
<211> 108
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region"

<400> 1690
Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Asp Tyr 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Arg Pro Gly Gln Ala Pro Arg Leu Leu Ile 
        35                  40                  45              


Tyr Asp Ala Ser Thr Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser Gly 
    50                  55                  60                  


Gly Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Val Tyr Tyr Cys Gln His Arg Asn Asn Trp Pro Ser 
                85                  90                  95      


Leu Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105             


<210> 1691
<211> 11
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L1"

<400> 1691
Arg Ala Ser Gln Ser Val Ser Asp Tyr Leu Ala 
1               5                   10      


<210> 1692
<211> 33
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L1"

<400> 1692
agggccagtc agagtgttag cgactacttg gcc                                    33


<210> 1693
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L2"

<400> 1693
Asp Ala Ser Thr Arg Ala Thr 
1               5           


<210> 1694
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L2"

<400> 1694
gatgcgtcca ccagggccac t                                                 21


<210> 1695
<211> 10
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L3"

<400> 1695
Gln His Arg Asn Asn Trp Pro Ser Leu Thr 
1               5                   10  


<210> 1696
<211> 30
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L3"

<400> 1696
caacaccgta acaactggcc ttccctcact                                        30


<210> 1697
<211> 381
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region"

<400> 1697
caggtgcagc tacagcagtg gggcgcagga ctgctgaagc cttcggagac cctgtccctc       60

acctgcggtg tctctgatgg gtccttcagt gcctactact ggaactggat ccgccagtcc      120

ccagggaagg ggctggagtg gattggggaa accaatccaa gtgaaaacac caactacagc      180

ccgtccctca agaatcgagt caccatatcg gcagacaggt ccgcgaatca gttctccctg      240

agactgaggt ctgtgaccgc cgcggacacg ggtgtttatt actgtgcgag aggccgcggt      300

tattatggtt cgacgactga ttatcggggg ctccactggt tcgacccctg gggccaggga      360

accctggtca ccgtctcctc a                                                381


<210> 1698
<211> 127
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region"

<400> 1698
Gln Val Gln Leu Gln Gln Trp Gly Ala Gly Leu Leu Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Gly Val Ser Asp Gly Ser Phe Ser Ala Tyr 
            20                  25                  30          


Tyr Trp Asn Trp Ile Arg Gln Ser Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Glu Thr Asn Pro Ser Glu Asn Thr Asn Tyr Ser Pro Ser Leu Lys 
    50                  55                  60                  


Asn Arg Val Thr Ile Ser Ala Asp Arg Ser Ala Asn Gln Phe Ser Leu 
65                  70                  75                  80  


Arg Leu Arg Ser Val Thr Ala Ala Asp Thr Gly Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Gly Arg Gly Tyr Tyr Gly Ser Thr Thr Asp Tyr Arg Gly Leu His 
            100                 105                 110         


Trp Phe Asp Pro Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125         


<210> 1699
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H1"

<400> 1699
Gly Ser Phe Ser Ala Tyr Tyr Trp Asn 
1               5                   


<210> 1700
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H1"

<400> 1700
gggtccttca gtgcctacta ctggaac                                           27


<210> 1701
<211> 16
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H2"

<400> 1701
Glu Thr Asn Pro Ser Glu Asn Thr Asn Tyr Ser Pro Ser Leu Lys Asn 
1               5                   10                  15      


<210> 1702
<211> 48
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H2"

<400> 1702
gaaaccaatc caagtgaaaa caccaactac agcccgtccc tcaagaat                    48


<210> 1703
<211> 21
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H3"

<400> 1703
Ala Arg Gly Arg Gly Tyr Tyr Gly Ser Thr Thr Asp Tyr Arg Gly Leu 
1               5                   10                  15      


His Trp Phe Asp Pro 
            20      


<210> 1704
<211> 63
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H3"

<400> 1704
gcgagaggcc gcggttatta tggttcgacg actgattatc gggggctcca ctggttcgac       60

ccc                                                                     63


<210> 1705
<211> 321
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region"

<400> 1705
gaaacgacac tcacgcagtc tccagtcacc ctgtctgtgt ctccagggga aagagccacc       60

ctctcctgca gggccagtca gagtgttagc ttcaacttag cctggtacca gcagaaacct      120

ggccaggctc ccaggctcct catctatggt gcatccacca gggtcactaa tctcccactc      180

aggttcagtg gcagtgggtc tgggacagag ttcactctca ccatcagcag cctgcagtct      240

gaagattttg cagtttatta ctgtcagcag tataataact ggcctcggac ttttggccag      300

gggaccaagc tggagatcaa a                                                321


<210> 1706
<211> 107
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region"

<400> 1706
Glu Thr Thr Leu Thr Gln Ser Pro Val Thr Leu Ser Val Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Phe Asn 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 
        35                  40                  45              


Tyr Gly Ala Ser Thr Arg Val Thr Asn Leu Pro Leu Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Ser 
65                  70                  75                  80  


Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Asn Asn Trp Pro Arg 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210> 1707
<211> 11
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L1"

<400> 1707
Arg Ala Ser Gln Ser Val Ser Phe Asn Leu Ala 
1               5                   10      


<210> 1708
<211> 33
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L1"

<400> 1708
agggccagtc agagtgttag cttcaactta gcc                                    33


<210> 1709
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L2"

<400> 1709
Gly Ala Ser Thr Arg Val Thr 
1               5           


<210> 1710
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L2"

<400> 1710
ggtgcatcca ccagggtcac t                                                 21


<210> 1711
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L3"

<400> 1711
Gln Gln Tyr Asn Asn Trp Pro Arg Thr 
1               5                   


<210> 1712
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L3"

<400> 1712
cagcagtata ataactggcc tcggact                                           27


<210> 1713
<211> 378
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region"

<400> 1713
gaggtgcagc tggtggagtc tgggggaggc ttggttcagc cgggggggtc cctgagactc       60

tcctgtgcag cctctggatt cactttcagc gacttttcca tgagctgggt ccgccaggct      120

ccagggaagg ggctggaatg ggtctcactt attaaaagta gcggttatgc atactatgca      180

gactccgtga ggggccggtt caccatctcc agagacaatt ccaagaacac cctgtatctg      240

caaatgaaca gcctgagagc cgaggacacg gccatatatt attgtgcgaa agacgccgat      300

ttttggagtg gtgccgccta caatggagga tacaactttg actcctgggg ccagggaacc      360

ctggtcaccg tctcctca                                                    378


<210> 1714
<211> 126
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region"

<400> 1714
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp Phe 
            20                  25                  30          


Ser Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Leu Ile Lys Ser Ser Gly Tyr Ala Tyr Tyr Ala Asp Ser Val Arg 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Ile Tyr Tyr Cys Ala 
                85                  90                  95      


Lys Asp Ala Asp Phe Trp Ser Gly Ala Ala Tyr Asn Gly Gly Tyr Asn 
            100                 105                 110         


Phe Asp Ser Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125     


<210> 1715
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H1"

<400> 1715
Phe Thr Phe Ser Asp Phe Ser Met Ser 
1               5                   


<210> 1716
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H1"

<400> 1716
ttcactttca gcgacttttc catgagc                                           27


<210> 1717
<211> 16
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H2"

<400> 1717
Leu Ile Lys Ser Ser Gly Tyr Ala Tyr Tyr Ala Asp Ser Val Arg Gly 
1               5                   10                  15      


<210> 1718
<211> 48
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H2"

<400> 1718
cttattaaaa gtagcggtta tgcatactat gcagactccg tgaggggc                    48


<210> 1719
<211> 20
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H3"

<400> 1719
Ala Lys Asp Ala Asp Phe Trp Ser Gly Ala Ala Tyr Asn Gly Gly Tyr 
1               5                   10                  15      


Asn Phe Asp Ser 
            20  


<210> 1720
<211> 60
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H3"

<400> 1720
gcgaaagacg ccgatttttg gagtggtgcc gcctacaatg gaggatacaa ctttgactcc       60


<210> 1721
<211> 324
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region"

<400> 1721
gacatccaga tgacccagtc tccagccacc ctgtctgtat ttccagggga cagagccacc       60

ctctcctgca gggccagtca gagtgttggc agcaacttgg cctggtacca gcagaaacct      120

ggccaggctc ccaggctcct catctttggt gcctcaacca gggccactgg tatcccagcc      180

aggttcagtg gcagtgggtc tgggacagag ttcactctca ccatcagcag cctgcagtct      240

gaagattttg cagtttatta ctgtcagcag tatcataact ggcctccgct cactttcggc      300

ggagggacca aagtggatat caaa                                             324


<210> 1722
<211> 108
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region"

<400> 1722
Asp Ile Gln Met Thr Gln Ser Pro Ala Thr Leu Ser Val Phe Pro Gly 
1               5                   10                  15      


Asp Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Gly Ser Asn 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 
        35                  40                  45              


Phe Gly Ala Ser Thr Arg Ala Thr Gly Ile Pro Ala Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Ser 
65                  70                  75                  80  


Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr His Asn Trp Pro Pro 
                85                  90                  95      


Leu Thr Phe Gly Gly Gly Thr Lys Val Asp Ile Lys 
            100                 105             


<210> 1723
<211> 11
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L1"

<400> 1723
Arg Ala Ser Gln Ser Val Gly Ser Asn Leu Ala 
1               5                   10      


<210> 1724
<211> 33
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L1"

<400> 1724
agggccagtc agagtgttgg cagcaacttg gcc                                    33


<210> 1725
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L2"

<400> 1725
Gly Ala Ser Thr Arg Ala Thr 
1               5           


<210> 1726
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L2"

<400> 1726
ggtgcctcaa ccagggccac t                                                 21


<210> 1727
<211> 10
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L3"

<400> 1727
Gln Gln Tyr His Asn Trp Pro Pro Leu Thr 
1               5                   10  


<210> 1728
<211> 30
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      light chain variable region CDR L3"

<400> 1728
cagcagtatc ataactggcc tccgctcact                                        30


<210> 1729
<211> 375
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      Heavy chain variable region ('HC') nucleic acid sequence"

<400> 1729
caggtccagc ttgtacagtc tggggctgaa gtgaagaggc ctgggtcctc ggtgaaggtc       60

tcctgcaagg cttctggagg caccttcagc agctttggga tcaactgggt gcgacaggcc      120

cctggacaag ggcttgagtg gatgggaggg ctcaatccta tctttggtac accatctaac      180

gcacagaagt tccagggcag agtcacgatt accgcggacg aatccacgag cacagcctac      240

atggagctga gcagcctgag atctgaggac acggccgtct attactgtgc ctcattacga      300

tattttgact ggcaacctgg ggggtcctac tggttcgacc cctggggcca gggaaccctg      360

gtcaccgtct cctca                                                       375


<210> 1730
<211> 125
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      Heavy chain variable region ('HC') amino acid sequence"

<400> 1730
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Arg Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Ser Phe 
            20                  25                  30          


Gly Ile Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Gly Leu Asn Pro Ile Phe Gly Thr Pro Ser Asn Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ser Leu Arg Tyr Phe Asp Trp Gln Pro Gly Gly Ser Tyr Trp Phe 
            100                 105                 110         


Asp Pro Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125 


<210> 1731
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H1 ('H1') amino acid sequence"

<400> 1731
Gly Thr Phe Ser Ser Phe Gly Ile Asn 
1               5                   


<210> 1732
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H2 ('H2') amino acid sequence"

<400> 1732
Gly Leu Asn Pro Ile Phe Gly Thr Pro Ser Asn Ala Gln Lys Phe Gln 
1               5                   10                  15      


Gly 
    


<210> 1733
<211> 18
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H3 ('H3') amino acid sequence"

<400> 1733
Ala Ser Leu Arg Tyr Phe Asp Trp Gln Pro Gly Gly Ser Tyr Trp Phe 
1               5                   10                  15      


Asp Pro 
        


<210> 1734
<211> 330
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      Light chain variable region('LC') nucleic acid sequence"

<400> 1734
cagcctgggc tgactcagcc accctcagtg tcagtggccc caggaaagac ggccaggatt       60

gcctgtgggg gagacaacat tggaactaaa ggagtgcact ggtaccagca gaagccaggc      120

caggcccctg tgctggtcat ctattatgat agcgaccggc cctcagggat ccctgagcga      180

ttctctggtt ccaactctgg gaacacggcc accctgacca tcagcggggt cgaagccggg      240

gatgaggccg actactactg tcaggtttgg gatactattg atgattataa ggatggacta      300

ttcggcggag ggaccaagct caccgtccta                                       330


<210> 1735
<211> 110
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      Light chain variable region ('LC') amino acid sequence"

<400> 1735
Gln Pro Gly Leu Thr Gln Pro Pro Ser Val Ser Val Ala Pro Gly Lys 
1               5                   10                  15      


Thr Ala Arg Ile Ala Cys Gly Gly Asp Asn Ile Gly Thr Lys Gly Val 
            20                  25                  30          


His Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Val Leu Val Ile Tyr 
        35                  40                  45              


Tyr Asp Ser Asp Arg Pro Ser Gly Ile Pro Glu Arg Phe Ser Gly Ser 
    50                  55                  60                  


Asn Ser Gly Asn Thr Ala Thr Leu Thr Ile Ser Gly Val Glu Ala Gly 
65                  70                  75                  80  


Asp Glu Ala Asp Tyr Tyr Cys Gln Val Trp Asp Thr Ile Asp Asp Tyr 
                85                  90                  95      


Lys Asp Gly Leu Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 110 


<210> 1736
<211> 11
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L1 ('L1') amino acid sequence"

<400> 1736
Gly Gly Asp Asn Ile Gly Thr Lys Gly Val His 
1               5                   10      


<210> 1737
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L2 ('L2') amino acid sequence"

<400> 1737
Tyr Asp Ser Asp Arg Pro Ser 
1               5           


<210> 1738
<211> 13
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L3 ('L3') amino acid sequence"

<400> 1738
Gln Val Trp Asp Thr Ile Asp Asp Tyr Lys Asp Gly Leu 
1               5                   10              


<210> 1739
<211> 375
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      Heavy chain variable region ('HC') nucleic acid sequence"

<400> 1739
caggtccagc ttgtacagtc tggggctgaa gtgaagaggc ctgggtcctc ggtgaaggtc       60

tcctgcaagg cttctggagg caccttcagc agctttgcta tccagtgggt gcgacaggcc      120

cctggacaag ggcttgagtg gatgggaggg ctcatcccta tctttggtac accagagaac      180

gcacagaagt tccagggcag agtcacgatt accgcggacg aatccacgag cacagcctac      240

atggagctga gcagcctgag atctgaggac acggccgtct attactgtgc ctcattacga      300

tattttgact ggcaacctgg ggggtcctac tggttcgacc cctggggcca gggaaccctg      360

gtcaccgtct cctca                                                       375


<210> 1740
<211> 125
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      Heavy chain variable region ('HC') amino acid sequence"

<400> 1740
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Arg Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Ser Phe 
            20                  25                  30          


Ala Ile Gln Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Gly Leu Ile Pro Ile Phe Gly Thr Pro Glu Asn Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ser Leu Arg Tyr Phe Asp Trp Gln Pro Gly Gly Ser Tyr Trp Phe 
            100                 105                 110         


Asp Pro Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125 


<210> 1741
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H1 ('H1') amino acid sequence"

<400> 1741
Gly Thr Phe Ser Ser Phe Ala Ile Gln 
1               5                   


<210> 1742
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H2 ('H2') amino acid sequence"

<400> 1742
Gly Leu Ile Pro Ile Phe Gly Thr Pro Glu Asn Ala Gln Lys Phe Gln 
1               5                   10                  15      


Gly 
    


<210> 1743
<211> 18
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H3 ('H3') amino acid sequence"

<400> 1743
Ala Ser Leu Arg Tyr Phe Asp Trp Gln Pro Gly Gly Ser Tyr Trp Phe 
1               5                   10                  15      


Asp Pro 
        


<210> 1744
<211> 330
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      Light chain variable region('LC') nucleic acid sequence"

<400> 1744
cagcctgggc tgactcagcc accctcagtg tcagtggccc caggaaagac ggccaggatt       60

gcctgtgggg gagacaacat tggaactaaa ggagtgcact ggtaccagca gaagccaggc      120

caggcccctg tgctggtcat ctattatgat agcgaccggc cctcagggat ccctgagcga      180

ttctctggtt ccaactctgg gaacacggcc accctgacca tcagcggggt cgaagccggg      240

gatgaggccg actactactg tcaggtttgg gatactattg atgatcataa ggatggacta      300

ttcggcggag ggaccaagct caccgtccta                                       330


<210> 1745
<211> 110
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      Light chain variable region ('LC') amino acid sequence"

<400> 1745
Gln Pro Gly Leu Thr Gln Pro Pro Ser Val Ser Val Ala Pro Gly Lys 
1               5                   10                  15      


Thr Ala Arg Ile Ala Cys Gly Gly Asp Asn Ile Gly Thr Lys Gly Val 
            20                  25                  30          


His Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Val Leu Val Ile Tyr 
        35                  40                  45              


Tyr Asp Ser Asp Arg Pro Ser Gly Ile Pro Glu Arg Phe Ser Gly Ser 
    50                  55                  60                  


Asn Ser Gly Asn Thr Ala Thr Leu Thr Ile Ser Gly Val Glu Ala Gly 
65                  70                  75                  80  


Asp Glu Ala Asp Tyr Tyr Cys Gln Val Trp Asp Thr Ile Asp Asp His 
                85                  90                  95      


Lys Asp Gly Leu Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 110 


<210> 1746
<211> 11
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L1 ('L1') amino acid sequence"

<400> 1746
Gly Gly Asp Asn Ile Gly Thr Lys Gly Val His 
1               5                   10      


<210> 1747
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L2 ('L2') amino acid sequence"

<400> 1747
Tyr Asp Ser Asp Arg Pro Ser 
1               5           


<210> 1748
<211> 13
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L3 ('L3') amino acid sequence"

<400> 1748
Gln Val Trp Asp Thr Ile Asp Asp His Lys Asp Gly Leu 
1               5                   10              


<210> 1749
<211> 372
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      Heavy chain variable region ('HC') nucleic acid sequence"

<400> 1749
gaggtgcagc tgttggagtc tgggggaggc gtggtccagc ctgggaggtc cctgagactc       60

tcctgtgcag cctctggatt caccttcagt gacttttcta tgcactgggt ccgccaggct      120

ccaggcaagg ggctggagtg ggtggcactc atctcaaatg atggaagcaa taaatattat      180

tcagactccc tgaagggttc attcatcatc tccagagaca actccaagaa cacgctctat      240

ctccaactga acagcctggg agctgaggac acggctctct attactgtgc gagagatgcg      300

gttccccatt atgattacgt ctggggaaac tttgactact ggggccaggg aaccctggtc      360

actgtctcct ca                                                          372


<210> 1750
<211> 124
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      Heavy chain variable region ('HC') amino acid sequence"

<400> 1750
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp Phe 
            20                  25                  30          


Ser Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Leu Ile Ser Asn Asp Gly Ser Asn Lys Tyr Tyr Ser Asp Ser Leu 
    50                  55                  60                  


Lys Gly Ser Phe Ile Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Leu Asn Ser Leu Gly Ala Glu Asp Thr Ala Leu Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Ala Val Pro His Tyr Asp Tyr Val Trp Gly Asn Phe Asp 
            100                 105                 110         


Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 


<210> 1751
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H1 ('H1') amino acid sequence"

<400> 1751
Phe Thr Phe Ser Asp Phe Ser Met His 
1               5                   


<210> 1752
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H2 ('H2') amino acid sequence"

<400> 1752
Leu Ile Ser Asn Asp Gly Ser Asn Lys Tyr Tyr Ser Asp Ser Leu Lys 
1               5                   10                  15      


Gly 
    


<210> 1753
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H3 ('H3') amino acid sequence"

<400> 1753
Ala Arg Asp Ala Val Pro His Tyr Asp Tyr Val Trp Gly Asn Phe Asp 
1               5                   10                  15      


Tyr 
    


<210> 1754
<211> 372
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      Light chain variable region('LC') nucleic acid sequence"

<400> 1754
gaggtgcagc tgttggagtc tgggggaggc gtggtccagc ctgggaggtc cctgagactc       60

tcctgtgcag cctctggatt caccttcagt gacttttcta tgcactgggt ccgccaggct      120

ccaggcaagg ggctggagtg ggtggcactc atctcaaatg atggaagcaa taaatattat      180

tcagactccc tgaagggttc attcatcatc tccagagaca actccaagaa cacgctctat      240

ctccaactga acagcctggg agctgaggac acggctctct attactgtgc gagagatgcg      300

gttccccatt atgattacgt ctggggaaac tttgactact ggggccaggg aaccctggtc      360

actgtctcct ca                                                          372


<210> 1755
<211> 124
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      Light chain variable region ('LC') amino acid sequence"

<400> 1755
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp Phe 
            20                  25                  30          


Ser Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Leu Ile Ser Asn Asp Gly Ser Asn Lys Tyr Tyr Ser Asp Ser Leu 
    50                  55                  60                  


Lys Gly Ser Phe Ile Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Leu Asn Ser Leu Gly Ala Glu Asp Thr Ala Leu Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Ala Val Pro His Tyr Asp Tyr Val Trp Gly Asn Phe Asp 
            100                 105                 110         


Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 


<210> 1756
<211> 14
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L1 ('L1') amino acid sequence"

<400> 1756
Thr Gly Thr Ala Ser Asp Val Gly Gly Tyr Asn Tyr Val Ser 
1               5                   10                  


<210> 1757
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L2 ('L2') amino acid sequence"

<400> 1757
Glu Val Ser Asn Arg Pro Ser 
1               5           


<210> 1758
<211> 10
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L3 ('L3') amino acid sequence"

<400> 1758
Ser Ser Tyr Thr Ser Phe Thr Pro Val Val 
1               5                   10  


<210> 1759
<211> 372
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      Heavy chain variable region ('HC') nucleic acid sequence"

<400> 1759
gaggtgcagc tgttggagtc tgggggaggc gtggtccagc ctgggaggtc cctgagactc       60

tcctgtgcag cctctggatt caccttcagt gacttttcta tgcactgggt ccgccaggct      120

ccaggcaagg ggctggagtg ggtggcactc atctcaaatg atggaagcaa taaatattat      180

tcagactccc tgaagggttc attcatcatc tccagagaca actccaagaa cacgctctat      240

ctccaactga acagcctggg agctgaggac acggctctct attactgtgc gagagatgcg      300

gttccccatt atgattacgt ctggggaaac tttgactact ggggccaggg aaccctggtc      360

actgtctcct ca                                                          372


<210> 1760
<211> 124
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      Heavy chain variable region ('HC') amino acid sequence"

<400> 1760
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp Phe 
            20                  25                  30          


Ser Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Leu Ile Ser Asn Asp Gly Ser Asn Lys Tyr Tyr Ser Asp Ser Leu 
    50                  55                  60                  


Lys Gly Ser Phe Ile Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Leu Asn Ser Leu Gly Ala Glu Asp Thr Ala Leu Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Ala Val Pro His Tyr Asp Tyr Val Trp Gly Asn Phe Asp 
            100                 105                 110         


Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 


<210> 1761
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H1 ('H1') amino acid sequence"

<400> 1761
Phe Thr Phe Ser Asp Phe Ser Met His 
1               5                   


<210> 1762
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H2 ('H2') amino acid sequence"

<400> 1762
Leu Ile Ser Asn Asp Gly Ser Asn Lys Tyr Tyr Ser Asp Ser Leu Lys 
1               5                   10                  15      


Gly 
    


<210> 1763
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H3 ('H3') amino acid sequence"

<400> 1763
Ala Arg Asp Ala Val Pro His Tyr Asp Tyr Val Trp Gly Asn Phe Asp 
1               5                   10                  15      


Tyr 
    


<210> 1764
<211> 330
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      Light chain variable region('LC') nucleic acid sequence"

<400> 1764
cagtctgttc tgactcagcc tgcctccgtg tctgcgtctc ctggacagtc gatcaccatc       60

tcctgcactg gaaccgcgag tgacgttggt ggttataatt atgtctcctg gtaccaacag      120

cacccaggca aagcccccaa actcataatt tatgaggtca gtaatcggcc ctcaggggtt      180

tctaatcgct tctctggctc caagtctggc aacacggcct ccctgaccat ctctgggctc      240

caggctgacg acgaggctga ttattactgc agctcatata cagctttcac tcccgtggta      300

ttcggcggag ggaccaagct gaccgtccta                                       330


<210> 1765
<211> 110
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      Light chain variable region ('LC') amino acid sequence"

<400> 1765
Gln Ser Val Leu Thr Gln Pro Ala Ser Val Ser Ala Ser Pro Gly Gln 
1               5                   10                  15      


Ser Ile Thr Ile Ser Cys Thr Gly Thr Ala Ser Asp Val Gly Gly Tyr 
            20                  25                  30          


Asn Tyr Val Ser Trp Tyr Gln Gln His Pro Gly Lys Ala Pro Lys Leu 
        35                  40                  45              


Ile Ile Tyr Glu Val Ser Asn Arg Pro Ser Gly Val Ser Asn Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Asn Thr Ala Ser Leu Thr Ile Ser Gly Leu 
65                  70                  75                  80  


Gln Ala Asp Asp Glu Ala Asp Tyr Tyr Cys Ser Ser Tyr Thr Ala Phe 
                85                  90                  95      


Thr Pro Val Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 110 


<210> 1766
<211> 14
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L1 ('L1') amino acid sequence"

<400> 1766
Thr Gly Thr Ala Ser Asp Val Gly Gly Tyr Asn Tyr Val Ser 
1               5                   10                  


<210> 1767
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L2 ('L2') amino acid sequence"

<400> 1767
Glu Val Ser Asn Arg Pro Ser 
1               5           


<210> 1768
<211> 10
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L3 ('L3') amino acid sequence"

<400> 1768
Ser Ser Tyr Thr Ala Phe Thr Pro Val Val 
1               5                   10  


<210> 1769
<211> 372
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      Heavy chain variable region ('HC') nucleic acid sequence"

<400> 1769
gaggtgcagc tgttggagtc tgggggaggc gtggtccagc ctgggaggtc cctgagactc       60

tcctgtgcag cctctggatt caccttcagt gacttttcta tgcactgggt ccgccaggct      120

ccaggcaagg ggctggagtg ggtggcactc atctcaaatg atggaagcaa taaatattat      180

tcagactccc tgaagggttc attcatcatc tccagagaca actccaagaa cacgctctat      240

ctccaactga acagcctggg agctgaggac acggctctct attactgtgc gagagatgcg      300

gttccccatt atgattacgt ctggggaaac tttgactact ggggccaggg aaccctggtc      360

actgtctcct ca                                                          372


<210> 1770
<211> 124
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      Heavy chain variable region ('HC') amino acid sequence"

<400> 1770
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp Phe 
            20                  25                  30          


Ser Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Leu Ile Ser Asn Asp Gly Ser Asn Lys Tyr Tyr Ser Asp Ser Leu 
    50                  55                  60                  


Lys Gly Ser Phe Ile Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Leu Asn Ser Leu Gly Ala Glu Asp Thr Ala Leu Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Ala Val Pro His Tyr Asp Tyr Val Trp Gly Asn Phe Asp 
            100                 105                 110         


Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 


<210> 1771
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H1 ('H1') amino acid sequence"

<400> 1771
Phe Thr Phe Ser Asp Phe Ser Met His 
1               5                   


<210> 1772
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H2 ('H2') amino acid sequence"

<400> 1772
Leu Ile Ser Asn Asp Gly Ser Asn Lys Tyr Tyr Ser Asp Ser Leu Lys 
1               5                   10                  15      


Gly 
    


<210> 1773
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H3 ('H3') amino acid sequence"

<400> 1773
Ala Arg Asp Ala Val Pro His Tyr Asp Tyr Val Trp Gly Asn Phe Asp 
1               5                   10                  15      


Tyr 
    


<210> 1774
<211> 330
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      Light chain variable region('LC') nucleic acid sequence"

<400> 1774
cagtctgttc tgactcagcc tgcctccgtg tctgcgtctc ctggacagtc gatcaccatc       60

tcctgcactg gaaccgcgag tgacgttggt ggttataatt atgtctcctg gtaccaacag      120

cacccaggca aagcccccaa actcataatt tatgagaaga gtaatcggcc ctcaggggtt      180

tctaatcgct tctctggctc caagtctggc aacacggcct ccctgaccat ctctgggctc      240

caggctgacg acgaggctga ttattactgc agctcatata caagtttcac tcccgtggta      300

ttcggcggag ggaccaagct gaccgtccta                                       330


<210> 1775
<211> 110
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      Light chain variable region ('LC') amino acid sequence"

<400> 1775
Gln Ser Val Leu Thr Gln Pro Ala Ser Val Ser Ala Ser Pro Gly Gln 
1               5                   10                  15      


Ser Ile Thr Ile Ser Cys Thr Gly Thr Ala Ser Asp Val Gly Gly Tyr 
            20                  25                  30          


Asn Tyr Val Ser Trp Tyr Gln Gln His Pro Gly Lys Ala Pro Lys Leu 
        35                  40                  45              


Ile Ile Tyr Glu Lys Ser Asn Arg Pro Ser Gly Val Ser Asn Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Asn Thr Ala Ser Leu Thr Ile Ser Gly Leu 
65                  70                  75                  80  


Gln Ala Asp Asp Glu Ala Asp Tyr Tyr Cys Ser Ser Tyr Thr Ser Phe 
                85                  90                  95      


Thr Pro Val Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 110 


<210> 1776
<211> 14
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L1 ('L1') amino acid sequence"

<400> 1776
Thr Gly Thr Ala Ser Asp Val Gly Gly Tyr Asn Tyr Val Ser 
1               5                   10                  


<210> 1777
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L2 ('L2') amino acid sequence"

<400> 1777
Glu Lys Ser Asn Arg Pro Ser 
1               5           


<210> 1778
<211> 10
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L3 ('L3') amino acid sequence"

<400> 1778
Ser Ser Tyr Thr Ser Phe Thr Pro Val Val 
1               5                   10  


<210> 1779
<211> 366
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      Heavy chain variable region ('HC') nucleic acid sequence"

<400> 1779
caggtccagc tggtacagtc tgggggaggc ctggtcaagc ctggggggtc cctgagactc       60

tcttgtgcag cctctggatt caccttcagt agctatacca tgaactgggt ccgccaggct      120

ccagggaagg ggctggagtg ggtctcatcc attactggtg gtagtagttt cacaaactac      180

gcagactcac tggagggccg attcaccatc tccagagata acgccaagag ctcacttttt      240

ctgcaaatga acagcctgag agtcgaggac acggctgtat attactgtgc gagagatcag      300

ccggggacga tttttggagt ggtccaggac tactggggcc agggaaccct ggtcaccgtc      360

tcctca                                                                 366


<210> 1780
<211> 122
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      Heavy chain variable region ('HC') amino acid sequence"

<400> 1780
Gln Val Gln Leu Val Gln Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Thr Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ser Ile Thr Gly Gly Ser Ser Phe Thr Asn Tyr Ala Asp Ser Leu 
    50                  55                  60                  


Glu Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Ser Ser Leu Phe 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Val Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Gln Pro Gly Thr Ile Phe Gly Val Val Gln Asp Tyr Trp 
            100                 105                 110         


Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120         


<210> 1781
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H1 ('H1') amino acid sequence"

<400> 1781
Phe Thr Phe Ser Ser Tyr Thr Met Asn 
1               5                   


<210> 1782
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H2 ('H2') amino acid sequence"

<400> 1782
Ser Ile Thr Gly Gly Ser Ser Phe Thr Asn Tyr Ala Asp Ser Leu Glu 
1               5                   10                  15      


Gly 
    


<210> 1783
<211> 15
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H3 ('H3') amino acid sequence"

<400> 1783
Ala Arg Asp Gln Pro Gly Thr Ile Phe Gly Val Val Gln Asp Tyr 
1               5                   10                  15  


<210> 1784
<211> 330
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      Light chain variable region('LC') nucleic acid sequence"

<400> 1784
cagtctgtct tgacgcagcc gccctcagtg tctggggccc cagggcagag ggtcaccatc       60

tcctgcactg ggggcagctc caacatcggg gcaggttatg atgtgcactg gtaccagcag      120

cttccaggaa cagcccctaa actcctcatc tatggtaaca gcaatcgggg gtcaggggtc      180

cctgaccgat tctctggctc caagtctggc acctcagcct ccctggccat cactgggctc      240

caggctgagg atgaggctga ttattactgc cagtcctatg acagccgcct gcaggtggta      300

ttcggcggag ggaccaaggt gaccgtccta                                       330


<210> 1785
<211> 110
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      Light chain variable region ('LC') amino acid sequence"

<400> 1785
Gln Ser Val Leu Thr Gln Pro Pro Ser Val Ser Gly Ala Pro Gly Gln 
1               5                   10                  15      


Arg Val Thr Ile Ser Cys Thr Gly Gly Ser Ser Asn Ile Gly Ala Gly 
            20                  25                  30          


Tyr Asp Val His Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu 
        35                  40                  45              


Leu Ile Tyr Gly Asn Ser Asn Arg Gly Ser Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Thr Gly Leu 
65                  70                  75                  80  


Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Gln Ser Tyr Asp Ser Arg 
                85                  90                  95      


Leu Gln Val Val Phe Gly Gly Gly Thr Lys Val Thr Val Leu 
            100                 105                 110 


<210> 1786
<211> 14
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L1 ('L1') amino acid sequence"

<400> 1786
Thr Gly Gly Ser Ser Asn Ile Gly Ala Gly Tyr Asp Val His 
1               5                   10                  


<210> 1787
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L2 ('L2') amino acid sequence"

<400> 1787
Gly Asn Ser Asn Arg Gly Ser 
1               5           


<210> 1788
<211> 10
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L3 ('L3') amino acid sequence"

<400> 1788
Gln Ser Tyr Asp Ser Arg Leu Gln Val Val 
1               5                   10  


<210> 1789
<211> 366
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      Heavy chain variable region ('HC') nucleic acid sequence"

<400> 1789
caggtccagc tggtacagtc tgggggaggc ctggtcaagc ctggggggtc cctgagactc       60

tcttgtgcag cctctggatt caccttcagt agctatacca tgaactgggt ccgccaggct      120

ccagggaagg ggctggagtg ggtctcatcc attactggtg gtagtagttt cacaaactac      180

gcagactcac tggagggccg attcaccatc tccagagata acgccaagag ctcacttttt      240

ctgcaaatga acagcctgag agtcgaggac acggctgtat attactgtgc gagagatcag      300

ccggggacga tttttggagt ggtccaggac tactggggcc agggaaccct ggtcaccgtc      360

tcctca                                                                 366


<210> 1790
<211> 122
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      Heavy chain variable region ('HC') amino acid sequence"

<400> 1790
Gln Val Gln Leu Val Gln Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Thr Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ser Ile Thr Gly Gly Ser Ser Phe Thr Asn Tyr Ala Asp Ser Leu 
    50                  55                  60                  


Glu Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Ser Ser Leu Phe 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Val Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Gln Pro Gly Thr Ile Phe Gly Val Val Gln Asp Tyr Trp 
            100                 105                 110         


Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120         


<210> 1791
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H1 ('H1') amino acid sequence"

<400> 1791
Phe Thr Phe Ser Ser Tyr Thr Met Asn 
1               5                   


<210> 1792
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H2 ('H2') amino acid sequence"

<400> 1792
Ser Ile Thr Gly Gly Ser Ser Phe Thr Asn Tyr Ala Asp Ser Leu Glu 
1               5                   10                  15      


Gly 
    


<210> 1793
<211> 15
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H3 ('H3') amino acid sequence"

<400> 1793
Ala Arg Asp Gln Pro Gly Thr Ile Phe Gly Val Val Gln Asp Tyr 
1               5                   10                  15  


<210> 1794
<211> 330
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      Light chain variable region('LC') nucleic acid sequence"

<400> 1794
cagtctgtct tgacgcagcc gccctcagtg tctggggccc cagggcagag ggtcaccatc       60

tcctgcactg ggggcagctc caacatcggg aagggttatg atgtgcactg gtaccagcag      120

cttccaggaa cagcccccaa actcctcatc tatggtaaca gcaatcggcc cgggggggtc      180

cctgaccgat tctctggctc caagtctggc acctcagcct ccctggccat cactgggctc      240

caggctgagg atgaggctga ttattactgc cagtcctatg acagcgggct gagtgtggta      300

ttcggcggag ggaccaaggt gaccgtccta                                       330


<210> 1795
<211> 110
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      Light chain variable region ('LC') amino acid sequence"

<400> 1795
Gln Ser Val Leu Thr Gln Pro Pro Ser Val Ser Gly Ala Pro Gly Gln 
1               5                   10                  15      


Arg Val Thr Ile Ser Cys Thr Gly Gly Ser Ser Asn Ile Gly Lys Gly 
            20                  25                  30          


Tyr Asp Val His Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu 
        35                  40                  45              


Leu Ile Tyr Gly Asn Ser Asn Arg Pro Gly Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Thr Gly Leu 
65                  70                  75                  80  


Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Gln Ser Tyr Asp Ser Gly 
                85                  90                  95      


Leu Ser Val Val Phe Gly Gly Gly Thr Lys Val Thr Val Leu 
            100                 105                 110 


<210> 1796
<211> 14
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L1 ('L1') amino acid sequence"

<400> 1796
Thr Gly Gly Ser Ser Asn Ile Gly Lys Gly Tyr Asp Val His 
1               5                   10                  


<210> 1797
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L2 ('L2') amino acid sequence"

<400> 1797
Gly Asn Ser Asn Arg Pro Gly 
1               5           


<210> 1798
<211> 10
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L3 ('L3') amino acid sequence"

<400> 1798
Gln Ser Tyr Asp Ser Gly Leu Ser Val Val 
1               5                   10  


<210> 1799
<211> 366
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      Heavy chain variable region ('HC') nucleic acid sequence"

<400> 1799
caggtccagc tggtacagtc tgggggaggc ctggtcaagc ctggggggtc cctgagactc       60

tcttgtgcag cctctggatt caagttcagt agctatacca tgaactgggt ccgccaggct      120

ccagggaagg ggctggagtg ggtctcatcc attactggtg gtagtagttt cacaaactac      180

gcagactcac tggagggccg attcaccatc tccagagata acgccaagag ctcacttttt      240

ctgcaaatga acagcctgag agtcgaggac acggctgtat attactgtgc gagagatcag      300

ccggggacga tttttggagt ggtccaggac tactggggcc agggaaccct ggtcaccgtc      360

tcctca                                                                 366


<210> 1800
<211> 122
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      Heavy chain variable region ('HC') amino acid sequence"

<400> 1800
Gln Val Gln Leu Val Gln Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Lys Phe Ser Ser Tyr 
            20                  25                  30          


Thr Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ser Ile Thr Gly Gly Ser Ser Phe Thr Asn Tyr Ala Asp Ser Leu 
    50                  55                  60                  


Glu Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Ser Ser Leu Phe 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Val Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Gln Pro Gly Thr Ile Phe Gly Val Val Gln Asp Tyr Trp 
            100                 105                 110         


Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120         


<210> 1801
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H1 ('H1') amino acid sequence"

<400> 1801
Phe Lys Phe Ser Ser Tyr Thr Met Asn 
1               5                   


<210> 1802
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H2 ('H2') amino acid sequence"

<400> 1802
Ser Ile Thr Gly Gly Ser Ser Phe Thr Asn Tyr Ala Asp Ser Leu Glu 
1               5                   10                  15      


Gly 
    


<210> 1803
<211> 15
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H3 ('H3') amino acid sequence"

<400> 1803
Ala Arg Asp Gln Pro Gly Thr Ile Phe Gly Val Val Gln Asp Tyr 
1               5                   10                  15  


<210> 1804
<211> 330
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      Light chain variable region('LC') nucleic acid sequence"

<400> 1804
cagtctgtct tgacgcagcc gccctcagtg tctggggccc cagggcagag ggtcaccatc       60

tcctgcactg ggggcagctc caacatcggg gcaggttatg atgtgcactg gtaccagcag      120

cttccaggaa cagcccccaa actcctcatc tatggtaaca gcaatcggcc ctcaggggtc      180

cctgaccgat tctctggctc caagtctggc acctcagcct ccctggccat cactgggctc      240

caggctgagg atgaggctga ttattactgc cagtcctatg acagccgcct gagtgtggta      300

ttcggcggag ggaccaaggt gaccgtccta                                       330


<210> 1805
<211> 110
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      Light chain variable region ('LC') amino acid sequence"

<400> 1805
Gln Ser Val Leu Thr Gln Pro Pro Ser Val Ser Gly Ala Pro Gly Gln 
1               5                   10                  15      


Arg Val Thr Ile Ser Cys Thr Gly Gly Ser Ser Asn Ile Gly Ala Gly 
            20                  25                  30          


Tyr Asp Val His Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu 
        35                  40                  45              


Leu Ile Tyr Gly Asn Ser Asn Arg Pro Ser Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Thr Gly Leu 
65                  70                  75                  80  


Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Gln Ser Tyr Asp Ser Arg 
                85                  90                  95      


Leu Ser Val Val Phe Gly Gly Gly Thr Lys Val Thr Val Leu 
            100                 105                 110 


<210> 1806
<211> 14
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L1 ('L1') amino acid sequence"

<400> 1806
Thr Gly Gly Ser Ser Asn Ile Gly Ala Gly Tyr Asp Val His 
1               5                   10                  


<210> 1807
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L2 ('L2') amino acid sequence"

<400> 1807
Gly Asn Ser Asn Arg Pro Ser 
1               5           


<210> 1808
<211> 10
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L3 ('L3') amino acid sequence"

<400> 1808
Gln Ser Tyr Asp Ser Arg Leu Ser Val Val 
1               5                   10  


<210> 1809
<211> 366
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      Heavy chain variable region ('HC') nucleic acid sequence"

<400> 1809
caggtccagc tggtacagtc tgggggaggc ctggtcaagc ctggggggtc cctgagactc       60

tcttgtgcag cctctggatt cagcttcagt agctatagca tgaactgggt ccgccaggct      120

ccagggaagg ggctggagtg ggtctcatcc attactggtg gtagtagttt cgttaactac      180

gcagactcac tggagggccg attcaccatc tccagagata acgccaagag ctcacttttt      240

ctgcaaatga acagcctgag agtcgaggac acggctgtat attactgtgc gagagatcag      300

ccggggacga tttttggagt ggtccaggac tactggggcc agggaaccct ggtcaccgtc      360

tcctca                                                                 366


<210> 1810
<211> 122
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      Heavy chain variable region ('HC') amino acid sequence"

<400> 1810
Gln Val Gln Leu Val Gln Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ser Phe Ser Ser Tyr 
            20                  25                  30          


Ser Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ser Ile Thr Gly Gly Ser Ser Phe Val Asn Tyr Ala Asp Ser Leu 
    50                  55                  60                  


Glu Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Ser Ser Leu Phe 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Val Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Gln Pro Gly Thr Ile Phe Gly Val Val Gln Asp Tyr Trp 
            100                 105                 110         


Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120         


<210> 1811
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H1 ('H1') amino acid sequence"

<400> 1811
Phe Ser Phe Ser Ser Tyr Ser Met Asn 
1               5                   


<210> 1812
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H2 ('H2') amino acid sequence"

<400> 1812
Ser Ile Thr Gly Gly Ser Ser Phe Val Asn Tyr Ala Asp Ser Leu Glu 
1               5                   10                  15      


Gly 
    


<210> 1813
<211> 15
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H3 ('H3') amino acid sequence"

<400> 1813
Ala Arg Asp Gln Pro Gly Thr Ile Phe Gly Val Val Gln Asp Tyr 
1               5                   10                  15  


<210> 1814
<211> 330
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      Light chain variable region('LC') nucleic acid sequence"

<400> 1814
cagtctgtct tgacgcagcc gccctcagtg tctggggccc cagggcagag ggtcaccatc       60

tcctgcactg ggggcagctc caacatcggg gcaggttatg atgtgcactg gtaccagcag      120

cttccaggaa cagcccccaa actcctcatc tatggtaaca gcaatcggcc ctcaggggtc      180

cctgaccgat tctctggctc caagtctggc acctcagcct ccctggccat cactgggctc      240

caggctgagg atgaggctga ttattactgc cagtcctatg acagccgcct gagtgtggta      300

ttcggcggag ggaccaaggt gaccgtccta                                       330


<210> 1815
<211> 110
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      Light chain variable region ('LC') amino acid sequence"

<400> 1815
Gln Ser Val Leu Thr Gln Pro Pro Ser Val Ser Gly Ala Pro Gly Gln 
1               5                   10                  15      


Arg Val Thr Ile Ser Cys Thr Gly Gly Ser Ser Asn Ile Gly Ala Gly 
            20                  25                  30          


Tyr Asp Val His Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu 
        35                  40                  45              


Leu Ile Tyr Gly Asn Ser Asn Arg Pro Ser Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Thr Gly Leu 
65                  70                  75                  80  


Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Gln Ser Tyr Asp Ser Arg 
                85                  90                  95      


Leu Ser Val Val Phe Gly Gly Gly Thr Lys Val Thr Val Leu 
            100                 105                 110 


<210> 1816
<211> 14
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L1 ('L1') amino acid sequence"

<400> 1816
Thr Gly Gly Ser Ser Asn Ile Gly Ala Gly Tyr Asp Val His 
1               5                   10                  


<210> 1817
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L2 ('L2') amino acid sequence"

<400> 1817
Gly Asn Ser Asn Arg Pro Ser 
1               5           


<210> 1818
<211> 10
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L3 ('L3') amino acid sequence"

<400> 1818
Gln Ser Tyr Asp Ser Arg Leu Ser Val Val 
1               5                   10  


<210> 1819
<211> 366
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      Heavy chain variable region ('HC') nucleic acid sequence"

<400> 1819
caggtccagc tggtacagtc tgggggaggc ctggtcaagc ctggggggtc cctgagactc       60

tcttgtgcag cctctggatt caagttcagt agctatacca tgaactgggt ccgccaggct      120

ccagggaagg ggctggagtg ggtctcatcc attactggtg gtagtagttt cacaaactac      180

gcagactcac tggagggccg attcaccatc tccagagata acgccaagag ctcacttttt      240

ctgcaaatga acagcctgag agtcgaggac acggctgtat attactgtgc gagagatcag      300

ccggggacga tttttggagt ggtccaggac tactggggcc agggaaccct ggtcaccgtc      360

tcctca                                                                 366


<210> 1820
<211> 122
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      Heavy chain variable region ('HC') amino acid sequence"

<400> 1820
Gln Val Gln Leu Val Gln Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Lys Phe Ser Ser Tyr 
            20                  25                  30          


Thr Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ser Ile Thr Gly Gly Ser Ser Phe Thr Asn Tyr Ala Asp Ser Leu 
    50                  55                  60                  


Glu Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Ser Ser Leu Phe 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Val Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Gln Pro Gly Thr Ile Phe Gly Val Val Gln Asp Tyr Trp 
            100                 105                 110         


Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120         


<210> 1821
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H1 ('H1') amino acid sequence"

<400> 1821
Phe Lys Phe Ser Ser Tyr Thr Met Asn 
1               5                   


<210> 1822
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H2 ('H2') amino acid sequence"

<400> 1822
Ser Ile Thr Gly Gly Ser Ser Phe Thr Asn Tyr Ala Asp Ser Leu Glu 
1               5                   10                  15      


Gly 
    


<210> 1823
<211> 15
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H3 ('H3') amino acid sequence"

<400> 1823
Ala Arg Asp Gln Pro Gly Thr Ile Phe Gly Val Val Gln Asp Tyr 
1               5                   10                  15  


<210> 1824
<211> 330
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      Light chain variable region('LC') nucleic acid sequence"

<400> 1824
cagtctgtct tgacgcagcc gccctcagtg tctggggccc cagggcagag ggtcaccatc       60

tcctgcactg ggggcagctc caacatcggg gcaggttatg atgtgcactg gtaccagcag      120

cttccaggaa cagcccctaa actcctcatc tatggtaaca gcaatcgggg gtcaggggtc      180

cctgaccgat tctctggctc caagtctggc acctcagcct ccctggccat cactgggctc      240

caggctgagg atgaggctga ttattactgc cagtcctatg acagccgcct gcaggtggta      300

ttcggcggag ggaccaaggt gaccgtccta                                       330


<210> 1825
<211> 110
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      Light chain variable region ('LC') amino acid sequence"

<400> 1825
Gln Ser Val Leu Thr Gln Pro Pro Ser Val Ser Gly Ala Pro Gly Gln 
1               5                   10                  15      


Arg Val Thr Ile Ser Cys Thr Gly Gly Ser Ser Asn Ile Gly Ala Gly 
            20                  25                  30          


Tyr Asp Val His Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu 
        35                  40                  45              


Leu Ile Tyr Gly Asn Ser Asn Arg Gly Ser Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Thr Gly Leu 
65                  70                  75                  80  


Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Gln Ser Tyr Asp Ser Arg 
                85                  90                  95      


Leu Gln Val Val Phe Gly Gly Gly Thr Lys Val Thr Val Leu 
            100                 105                 110 


<210> 1826
<211> 14
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L1 ('L1') amino acid sequence"

<400> 1826
Thr Gly Gly Ser Ser Asn Ile Gly Ala Gly Tyr Asp Val His 
1               5                   10                  


<210> 1827
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L2 ('L2') amino acid sequence"

<400> 1827
Gly Asn Ser Asn Arg Gly Ser 
1               5           


<210> 1828
<211> 10
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L3 ('L3') amino acid sequence"

<400> 1828
Gln Ser Tyr Asp Ser Arg Leu Gln Val Val 
1               5                   10  


<210> 1829
<211> 366
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      Heavy chain variable region ('HC') nucleic acid sequence"

<400> 1829
caggtccagc tggtacagtc tgggggaggc ctggtcaagc ctggggggtc cctgagactc       60

tcttgtgcag cctctggatt caagttcagt agctatacca tgaactgggt ccgccaggct      120

ccagggaagg ggctggagtg ggtctcatcc attactggtg gtagtagttt cacaaactac      180

gcagactcac tggagggccg attcaccatc tccagagata acgccaagag ctcacttttt      240

ctgcaaatga acagcctgag agtcgaggac acggctgtat attactgtgc gagagatcag      300

ccggggacga tttttggagt ggtccaggac tactggggcc agggaaccct ggtcaccgtc      360

tcctca                                                                 366


<210> 1830
<211> 122
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      Heavy chain variable region ('HC') amino acid sequence"

<400> 1830
Gln Val Gln Leu Val Gln Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Lys Phe Ser Ser Tyr 
            20                  25                  30          


Thr Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ser Ile Thr Gly Gly Ser Ser Phe Thr Asn Tyr Ala Asp Ser Leu 
    50                  55                  60                  


Glu Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Ser Ser Leu Phe 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Val Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Gln Pro Gly Thr Ile Phe Gly Val Val Gln Asp Tyr Trp 
            100                 105                 110         


Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120         


<210> 1831
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H1 ('H1') amino acid sequence"

<400> 1831
Phe Lys Phe Ser Ser Tyr Thr Met Asn 
1               5                   


<210> 1832
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H2 ('H2') amino acid sequence"

<400> 1832
Ser Ile Thr Gly Gly Ser Ser Phe Thr Asn Tyr Ala Asp Ser Leu Glu 
1               5                   10                  15      


Gly 
    


<210> 1833
<211> 15
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H3 ('H3') amino acid sequence"

<400> 1833
Ala Arg Asp Gln Pro Gly Thr Ile Phe Gly Val Val Gln Asp Tyr 
1               5                   10                  15  


<210> 1834
<211> 330
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      Light chain variable region('LC') nucleic acid sequence"

<400> 1834
cagtctgtct tgacgcagcc gccctcagtg tctggggccc cagggcagag ggtcaccatc       60

tcctgcactg ggggcagctc caacatcggg aagggttatg atgtgcactg gtaccagcag      120

cttccaggaa cagcccccaa actcctcatc tatggtaaca gcaatcggcc cgggggggtc      180

cctgaccgat tctctggctc caagtctggc acctcagcct ccctggccat cactgggctc      240

caggctgagg atgaggctga ttattactgc cagtcctatg acagcgggct gagtgtggta      300

ttcggcggag ggaccaaggt gaccgtccta                                       330


<210> 1835
<211> 110
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      Light chain variable region ('LC') amino acid sequence"

<400> 1835
Gln Ser Val Leu Thr Gln Pro Pro Ser Val Ser Gly Ala Pro Gly Gln 
1               5                   10                  15      


Arg Val Thr Ile Ser Cys Thr Gly Gly Ser Ser Asn Ile Gly Lys Gly 
            20                  25                  30          


Tyr Asp Val His Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu 
        35                  40                  45              


Leu Ile Tyr Gly Asn Ser Asn Arg Pro Gly Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Thr Gly Leu 
65                  70                  75                  80  


Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Gln Ser Tyr Asp Ser Gly 
                85                  90                  95      


Leu Ser Val Val Phe Gly Gly Gly Thr Lys Val Thr Val Leu 
            100                 105                 110 


<210> 1836
<211> 14
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L1 ('L1') amino acid sequence"

<400> 1836
Thr Gly Gly Ser Ser Asn Ile Gly Lys Gly Tyr Asp Val His 
1               5                   10                  


<210> 1837
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L2 ('L2') amino acid sequence"

<400> 1837
Gly Asn Ser Asn Arg Pro Gly 
1               5           


<210> 1838
<211> 10
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L3 ('L3') amino acid sequence"

<400> 1838
Gln Ser Tyr Asp Ser Gly Leu Ser Val Val 
1               5                   10  


<210> 1839
<211> 366
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      Heavy chain variable region ('HC') nucleic acid sequence"

<400> 1839
caggtccagc tggtacagtc tgggggaggc ctggtcaagc ctggggggtc cctgagactc       60

tcttgtgcag cctctggatt cagcttcagt agctatagca tgaactgggt ccgccaggct      120

ccagggaagg ggctggagtg ggtctcatcc attactggtg gtagtagttt cgttaactac      180

gcagactcac tggagggccg attcaccatc tccagagata acgccaagag ctcacttttt      240

ctgcaaatga acagcctgag agtcgaggac acggctgtat attactgtgc gagagatcag      300

ccggggacga tttttggagt ggtccaggac tactggggcc agggaaccct ggtcaccgtc      360

tcctca                                                                 366


<210> 1840
<211> 122
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      Heavy chain variable region ('HC') amino acid sequence"

<400> 1840
Gln Val Gln Leu Val Gln Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ser Phe Ser Ser Tyr 
            20                  25                  30          


Ser Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ser Ile Thr Gly Gly Ser Ser Phe Val Asn Tyr Ala Asp Ser Leu 
    50                  55                  60                  


Glu Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Ser Ser Leu Phe 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Val Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Gln Pro Gly Thr Ile Phe Gly Val Val Gln Asp Tyr Trp 
            100                 105                 110         


Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120         


<210> 1841
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H1 ('H1') amino acid sequence"

<400> 1841
Phe Ser Phe Ser Ser Tyr Ser Met Asn 
1               5                   


<210> 1842
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H2 ('H2') amino acid sequence"

<400> 1842
Ser Ile Thr Gly Gly Ser Ser Phe Val Asn Tyr Ala Asp Ser Leu Glu 
1               5                   10                  15      


Gly 
    


<210> 1843
<211> 15
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H3 ('H3') amino acid sequence"

<400> 1843
Ala Arg Asp Gln Pro Gly Thr Ile Phe Gly Val Val Gln Asp Tyr 
1               5                   10                  15  


<210> 1844
<211> 330
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      Light chain variable region('LC') nucleic acid sequence"

<400> 1844
cagtctgtct tgacgcagcc gccctcagtg tctggggccc cagggcagag ggtcaccatc       60

tcctgcactg ggggcagctc caacatcggg gcaggttatg atgtgcactg gtaccagcag      120

aatccaggaa cagcccctaa actcctcatc tatggtaaca gcaatcgggg gtcaggggtc      180

cctgaccgat tctctggctc caagtctggc acctcagcct ccctggccat cactgggctc      240

caggctgagg atgaggctga ttattactgc cagtcctatg acagccgcct gcaggtggta      300

ttcggcggag ggaccaaggt gaccgtccta                                       330


<210> 1845
<211> 110
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      Light chain variable region ('LC') amino acid sequence"

<400> 1845
Gln Ser Val Leu Thr Gln Pro Pro Ser Val Ser Gly Ala Pro Gly Gln 
1               5                   10                  15      


Arg Val Thr Ile Ser Cys Thr Gly Gly Ser Ser Asn Ile Gly Ala Gly 
            20                  25                  30          


Tyr Asp Val His Trp Tyr Gln Gln Asn Pro Gly Thr Ala Pro Lys Leu 
        35                  40                  45              


Leu Ile Tyr Gly Asn Ser Asn Arg Gly Ser Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Thr Gly Leu 
65                  70                  75                  80  


Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Gln Ser Tyr Asp Ser Arg 
                85                  90                  95      


Leu Gln Val Val Phe Gly Gly Gly Thr Lys Val Thr Val Leu 
            100                 105                 110 


<210> 1846
<211> 14
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L1 ('L1') amino acid sequence"

<400> 1846
Thr Gly Gly Ser Ser Asn Ile Gly Ala Gly Tyr Asp Val His 
1               5                   10                  


<210> 1847
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L2 ('L2') amino acid sequence"

<400> 1847
Gly Asn Ser Asn Arg Gly Ser 
1               5           


<210> 1848
<211> 10
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L3 ('L3') amino acid sequence"

<400> 1848
Gln Ser Tyr Asp Ser Arg Leu Gln Val Val 
1               5                   10  


<210> 1849
<211> 366
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      Heavy chain variable region ('HC') nucleic acid sequence"

<400> 1849
caggtccagc tggtacagtc tgggggaggc ctggtcaagc ctggggggtc cctgagactc       60

tcttgtgcag cctctggatt cagcttcagt agctatagca tgaactgggt ccgccaggct      120

ccagggaagg ggctggagtg ggtctcatcc attactggtg gtagtagttt cgttaactac      180

gcagactcac tggagggccg attcaccatc tccagagata acgccaagag ctcacttttt      240

ctgcaaatga acagcctgag agtcgaggac acggctgtat attactgtgc gagagatcag      300

ccggggacga tttttggagt ggtccaggac tactggggcc agggaaccct ggtcaccgtc      360

tcctca                                                                 366


<210> 1850
<211> 122
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      Heavy chain variable region ('HC') amino acid sequence"

<400> 1850
Gln Val Gln Leu Val Gln Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ser Phe Ser Ser Tyr 
            20                  25                  30          


Ser Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ser Ile Thr Gly Gly Ser Ser Phe Val Asn Tyr Ala Asp Ser Leu 
    50                  55                  60                  


Glu Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Ser Ser Leu Phe 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Val Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Gln Pro Gly Thr Ile Phe Gly Val Val Gln Asp Tyr Trp 
            100                 105                 110         


Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120         


<210> 1851
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H1 ('H1') amino acid sequence"

<400> 1851
Phe Ser Phe Ser Ser Tyr Ser Met Asn 
1               5                   


<210> 1852
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H2 ('H2') amino acid sequence"

<400> 1852
Ser Ile Thr Gly Gly Ser Ser Phe Val Asn Tyr Ala Asp Ser Leu Glu 
1               5                   10                  15      


Gly 
    


<210> 1853
<211> 15
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      Heavy chain variable region CDR H3 ('H3') amino acid sequence"

<400> 1853
Ala Arg Asp Gln Pro Gly Thr Ile Phe Gly Val Val Gln Asp Tyr 
1               5                   10                  15  


<210> 1854
<211> 330
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      Light chain variable region('LC') nucleic acid sequence"

<400> 1854
cagtctgtct tgacgcagcc gccctcagtg tctggggccc cagggcagag ggtcaccatc       60

tcctgcactg ggggcagctc caacatcggg aagggttatg atgtgcactg gtaccagcag      120

cttccaggaa cagcccccaa actcctcatc tatggtaaca gcaatcggcc cgggggggtc      180

cctgaccgat tctctggctc caagtctggc acctcagcct ccctggccat cactgggctc      240

caggctgagg atgaggctga ttattactgc cagtcctatg acagcgggct gagtgtggta      300

ttcggcggag ggaccaaggt gaccgtccta                                       330


<210> 1855
<211> 110
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      Light chain variable region ('LC') amino acid sequence"

<400> 1855
Gln Ser Val Leu Thr Gln Pro Pro Ser Val Ser Gly Ala Pro Gly Gln 
1               5                   10                  15      


Arg Val Thr Ile Ser Cys Thr Gly Gly Ser Ser Asn Ile Gly Lys Gly 
            20                  25                  30          


Tyr Asp Val His Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu 
        35                  40                  45              


Leu Ile Tyr Gly Asn Ser Asn Arg Pro Gly Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Thr Gly Leu 
65                  70                  75                  80  


Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Gln Ser Tyr Asp Ser Gly 
                85                  90                  95      


Leu Ser Val Val Phe Gly Gly Gly Thr Lys Val Thr Val Leu 
            100                 105                 110 


<210> 1856
<211> 14
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L1 ('L1') amino acid sequence"

<400> 1856
Thr Gly Gly Ser Ser Asn Ile Gly Lys Gly Tyr Asp Val His 
1               5                   10                  


<210> 1857
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L2 ('L2') amino acid sequence"

<400> 1857
Gly Asn Ser Asn Arg Pro Gly 
1               5           


<210> 1858
<211> 10
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      Light chain variable region CDR L3 ('L3') amino acid sequence"

<400> 1858
Gln Ser Tyr Asp Ser Gly Leu Ser Val Val 
1               5                   10  


