                               SEQUENCE LISTING

<110> ADIMAB LLC
 
<120> 

<130> 2009186-0166

<140>
<141>

<160> 1968  

<170> PatentIn version 3.5

<210> 1
<211> 363
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region

<400> 1
caggtccagc ttgtacagtc tggggctgag gtgaagaagc ctggggcctc agtgaaggtg       60

tcctgcaggg cttctggatt cgtcttcacc agttatgata tcaactgggt gcgacaggcc      120

ccggggcaag gtcttgagtg gatggggcga atgaacgctc acactggaca ggtgacgtat      180

gcccagaaat tccaggacaa agtctccatg accagggacg tctccataac gacagcctac      240

ctggaactga gtcgcctggc atctgaggac acggccgtct attactgtgc gaggcccgac      300

attaactggg gtcaagatgc ttttgatgtc tggggccagg gcacaatggt caccgtctct      360

tca                                                                    363


<210> 2
<211> 121
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region

<400> 2
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Arg Ala Ser Gly Phe Val Phe Thr Ser Tyr 
            20                  25                  30          


Asp Ile Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Arg Met Asn Ala His Thr Gly Gln Val Thr Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Asp Lys Val Ser Met Thr Arg Asp Val Ser Ile Thr Thr Ala Tyr 
65                  70                  75                  80  


Leu Glu Leu Ser Arg Leu Ala Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Pro Asp Ile Asn Trp Gly Gln Asp Ala Phe Asp Val Trp Gly 
            100                 105                 110         


Gln Gly Thr Met Val Thr Val Ser Ser 
        115                 120     


<210> 3
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H1

<400> 3
Phe Val Phe Thr Ser Tyr Asp Ile Asn 
1               5                   


<210> 4
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H1

<400> 4
ttcgtcttca ccagttatga tatcaac                                           27


<210> 5
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H2

<400> 5
Arg Met Asn Ala His Thr Gly Gln Val Thr Tyr Ala Gln Lys Phe Gln 
1               5                   10                  15      


Asp 
    


<210> 6
<211> 51
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H2

<400> 6
cgaatgaacg ctcacactgg acaggtgacg tatgcccaga aattccagga c                51


<210> 7
<211> 14
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H3

<400> 7
Ala Arg Pro Asp Ile Asn Trp Gly Gln Asp Ala Phe Asp Val 
1               5                   10                  


<210> 8
<211> 42
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H3

<400> 8
gcgaggcccg acattaactg gggtcaagat gcttttgatg tc                          42


<210> 9
<211> 318
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region

<400> 9
gacatccgga tgacccagtc tccttccacc ctgtctgcat ctataggagc cagagtcacc       60

atcacttgcc gggccagtca gaatattggt aacttcttgg cctggtatca gcagaagcca      120

gggaaagccc ctaaactcct gatctataag gcgtctactt tagatcctgg ggtcccatca      180

aggttcagcg gcagcggatc tgggacagaa ttcactctca ccatcaccag cctgcagcct      240

gatgatttcg caacatttta ctgccaacag tataagagtg accccacttt tggccagggg      300

accaaggtgg aaatcaaa                                                    318


<210> 10
<211> 106
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region

<400> 10
Asp Ile Arg Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Ile Gly 
1               5                   10                  15      


Ala Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asn Ile Gly Asn Phe 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Lys Ala Ser Thr Leu Asp Pro Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Thr Ser Leu Gln Pro 
65                  70                  75                  80  


Asp Asp Phe Ala Thr Phe Tyr Cys Gln Gln Tyr Lys Ser Asp Pro Thr 
                85                  90                  95      


Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105     


<210> 11
<211> 11
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region CDR L1

<400> 11
Arg Ala Ser Gln Asn Ile Gly Asn Phe Leu Ala 
1               5                   10      


<210> 12
<211> 33
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region CDR L1

<400> 12
cgggccagtc agaatattgg taacttcttg gcc                                    33


<210> 13
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region CDR L2

<400> 13
Lys Ala Ser Thr Leu Asp Pro 
1               5           


<210> 14
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region CDR L2

<400> 14
aaggcgtcta ctttagatcc t                                                 21


<210> 15
<211> 8
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region CDR L3

<400> 15
Gln Gln Tyr Lys Ser Asp Pro Thr 
1               5               


<210> 16
<211> 24
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region CDR L3

<400> 16
caacagtata agagtgaccc cact                                              24


<210> 17
<211> 384
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region

<400> 17
caggtccagc tggtgcagtc tggggctgag gtgaagaagc ctgggtcatc ggtgagggtc       60

tcctgtaggg cttcaggagt cactttgacc accgttgctg tcaactgggt gcgccaggtc      120

cctgggcaag ggcctgagtg gattggaggg atcctcgttg ggcttggtaa ggtcagactc      180

gcccagaaat ttgagaatcg agccactcta agggcggaca catctagcaa cacagcctac      240

atggagttga gcggcctgag atttgaggac acggccgtct attattgtgc gataatcgac      300

ccccaagatt gtactgctgc cagctgcttt tgggtcaact ggctcgaccc ctggggccag      360

ggaaccctgg tcaccgtctc ctca                                             384


<210> 18
<211> 128
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region

<400> 18
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Arg Val Ser Cys Arg Ala Ser Gly Val Thr Leu Thr Thr Val 
            20                  25                  30          


Ala Val Asn Trp Val Arg Gln Val Pro Gly Gln Gly Pro Glu Trp Ile 
        35                  40                  45              


Gly Gly Ile Leu Val Gly Leu Gly Lys Val Arg Leu Ala Gln Lys Phe 
    50                  55                  60                  


Glu Asn Arg Ala Thr Leu Arg Ala Asp Thr Ser Ser Asn Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Gly Leu Arg Phe Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ile Ile Asp Pro Gln Asp Cys Thr Ala Ala Ser Cys Phe Trp Val 
            100                 105                 110         


Asn Trp Leu Asp Pro Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125             


<210> 19
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H1

<400> 19
Val Thr Leu Thr Thr Val Ala Val Asn 
1               5                   


<210> 20
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H1

<400> 20
gtcactttga ccaccgttgc tgtcaac                                           27


<210> 21
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H2

<400> 21
Gly Ile Leu Val Gly Leu Gly Lys Val Arg Leu Ala Gln Lys Phe Glu 
1               5                   10                  15      


Asn 
    


<210> 22
<211> 51
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H2

<400> 22
gggatcctcg ttgggcttgg taaggtcaga ctcgcccaga aatttgagaa t                51


<210> 23
<211> 21
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H3

<400> 23
Ala Ile Ile Asp Pro Gln Asp Cys Thr Ala Ala Ser Cys Phe Trp Val 
1               5                   10                  15      


Asn Trp Leu Asp Pro 
            20      


<210> 24
<211> 63
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H3

<400> 24
gcgataatcg acccccaaga ttgtactgct gccagctgct tttgggtcaa ctggctcgac       60

ccc                                                                     63


<210> 25
<211> 324
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region

<400> 25
gaaattgtat tgacgcagtc tccaggcacc ctgaccttgt ctccagggga gacagccacc       60

ctctcctgca gggccagtca gagtgttctt agtggctact tagcctggta ccagcagaaa      120

cctggccagg ctcccaggct cctcatctat gctgcatcca ctagggccac tgacatccca      180

gcgaggttca ctggcagtgg gtctgcgaca gacttcactc tcaccatcag cagactggag      240

cctcaagatt ttgcagtgta ttactgtcag cagtatggtt cggctccgat caccttcggc      300

caagggacac gactggagat taaa                                             324


<210> 26
<211> 108
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region

<400> 26
Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Thr Leu Ser Pro Gly 
1               5                   10                  15      


Glu Thr Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Leu Ser Gly 
            20                  25                  30          


Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu 
        35                  40                  45              


Ile Tyr Ala Ala Ser Thr Arg Ala Thr Asp Ile Pro Ala Arg Phe Thr 
    50                  55                  60                  


Gly Ser Gly Ser Ala Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu 
65                  70                  75                  80  


Pro Gln Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Gly Ser Ala Pro 
                85                  90                  95      


Ile Thr Phe Gly Gln Gly Thr Arg Leu Glu Ile Lys 
            100                 105             


<210> 27
<211> 12
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region CDR L1

<400> 27
Arg Ala Ser Gln Ser Val Leu Ser Gly Tyr Leu Ala 
1               5                   10          


<210> 28
<211> 36
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region CDR L1

<400> 28
agggccagtc agagtgttct tagtggctac ttagcc                                 36


<210> 29
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region CDR L2

<400> 29
Ala Ala Ser Thr Arg Ala Thr 
1               5           


<210> 30
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region CDR L2

<400> 30
gctgcatcca ctagggccac t                                                 21


<210> 31
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region CDR L3

<400> 31
Gln Gln Tyr Gly Ser Ala Pro Ile Thr 
1               5                   


<210> 32
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region CDR L3

<400> 32
cagcagtatg gttcggctcc gatcacc                                           27


<210> 33
<211> 384
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region

<400> 33
caggtccagc tggtgcagtc tggggctgag gtaaagaagc ctgggtcatc ggtgaaggtc       60

tcctgcaagg cctctggagg caccatcaac aacgttgcta tcagttggct gcgacaggcc      120

cctggacaag gcctggagtg gctgggaggg aacatccctg gctttggtaa agtcagatac      180

tcacagcagt ttgagaccag actcacttta accgcggacg tctcgtccga cacagcctac      240

atggtgttga ccagcctaag atctgaagac acggccgtct attactgtgc gatcatcgac      300

ccccaacttt gcaccagagc cagctgcttt tgggtcaact ggctcgaccc ctggggccag      360

gggaccacgg tcaccgtctc ctca                                             384


<210> 34
<211> 128
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region

<400> 34
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Ile Asn Asn Val 
            20                  25                  30          


Ala Ile Ser Trp Leu Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Leu 
        35                  40                  45              


Gly Gly Asn Ile Pro Gly Phe Gly Lys Val Arg Tyr Ser Gln Gln Phe 
    50                  55                  60                  


Glu Thr Arg Leu Thr Leu Thr Ala Asp Val Ser Ser Asp Thr Ala Tyr 
65                  70                  75                  80  


Met Val Leu Thr Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ile Ile Asp Pro Gln Leu Cys Thr Arg Ala Ser Cys Phe Trp Val 
            100                 105                 110         


Asn Trp Leu Asp Pro Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120                 125             


<210> 35
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H1

<400> 35
Gly Thr Ile Asn Asn Val Ala Ile Ser 
1               5                   


<210> 36
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H1

<400> 36
ggcaccatca acaacgttgc tatcagt                                           27


<210> 37
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H2

<400> 37
Gly Asn Ile Pro Gly Phe Gly Lys Val Arg Tyr Ser Gln Gln Phe Glu 
1               5                   10                  15      


Thr 
    


<210> 38
<211> 51
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H2

<400> 38
gggaacatcc ctggctttgg taaagtcaga tactcacagc agtttgagac c                51


<210> 39
<211> 21
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H3

<400> 39
Ala Ile Ile Asp Pro Gln Leu Cys Thr Arg Ala Ser Cys Phe Trp Val 
1               5                   10                  15      


Asn Trp Leu Asp Pro 
            20      


<210> 40
<211> 63
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H3

<400> 40
gcgatcatcg acccccaact ttgcaccaga gccagctgct tttgggtcaa ctggctcgac       60

ccc                                                                     63


<210> 41
<211> 324
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region

<400> 41
gatattgtga tgactcagtc tccaggcacc ctgtctgtgt ctccagggga gagtgccgcc       60

ctctcctgcg gggccagtga gagtattctc agcgactcct tagcctggta ccagcataaa      120

cctggtcagg ctcccaggct cctcatctat ggtgcatcca gtagggccgc tggcatccca      180

gacaggttca gtggcagtgg gtctgggaca gacttcactc tcaccatcag cagactggag      240

ccagaggatt ttgcagtgta tttctgtcaa cagtttggtg ccttaccgat cactttcggc      300

caagggacac gactggagat taaa                                             324


<210> 42
<211> 108
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region

<400> 42
Asp Ile Val Met Thr Gln Ser Pro Gly Thr Leu Ser Val Ser Pro Gly 
1               5                   10                  15      


Glu Ser Ala Ala Leu Ser Cys Gly Ala Ser Glu Ser Ile Leu Ser Asp 
            20                  25                  30          


Ser Leu Ala Trp Tyr Gln His Lys Pro Gly Gln Ala Pro Arg Leu Leu 
        35                  40                  45              


Ile Tyr Gly Ala Ser Ser Arg Ala Ala Gly Ile Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu 
65                  70                  75                  80  


Pro Glu Asp Phe Ala Val Tyr Phe Cys Gln Gln Phe Gly Ala Leu Pro 
                85                  90                  95      


Ile Thr Phe Gly Gln Gly Thr Arg Leu Glu Ile Lys 
            100                 105             


<210> 43
<211> 12
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region CDR L1

<400> 43
Gly Ala Ser Glu Ser Ile Leu Ser Asp Ser Leu Ala 
1               5                   10          


<210> 44
<211> 36
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region CDR L1

<400> 44
ggggccagtg agagtattct cagcgactcc ttagcc                                 36


<210> 45
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region CDR L2

<400> 45
Gly Ala Ser Ser Arg Ala Ala 
1               5           


<210> 46
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region CDR L2

<400> 46
ggtgcatcca gtagggccgc t                                                 21


<210> 47
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region CDR L3

<400> 47
Gln Gln Phe Gly Ala Leu Pro Ile Thr 
1               5                   


<210> 48
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region CDR L3

<400> 48
caacagtttg gtgccttacc gatcact                                           27


<210> 49
<211> 363
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region

<400> 49
caggtgcagc tggtgcaatc tggggctgag gtgaagaagc cggggtcctc ggtgaaaatc       60

tcctgtaagg cttctggagg caccttcaac agtcaagcaa ttcactgggt gcgacaggcc      120

cctggacaag accttgagtg gatgggaaac atcatccctg ggttcggatc accaaactcc      180

gcgcagaact tccagggcag ggtcaccttc attgcggacg attccactgg cgctgcctac      240

atggacttga gtagcctgaa gtctgaagac acggccgtct attactgtgc gacagccggg      300

tggttcgggg aatcagttca tttggactca tggggccagg gaaccctggt caccgtctcc      360

tca                                                                    363


<210> 50
<211> 121
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region

<400> 50
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Ile Ser Cys Lys Ala Ser Gly Gly Thr Phe Asn Ser Gln 
            20                  25                  30          


Ala Ile His Trp Val Arg Gln Ala Pro Gly Gln Asp Leu Glu Trp Met 
        35                  40                  45              


Gly Asn Ile Ile Pro Gly Phe Gly Ser Pro Asn Ser Ala Gln Asn Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Phe Ile Ala Asp Asp Ser Thr Gly Ala Ala Tyr 
65                  70                  75                  80  


Met Asp Leu Ser Ser Leu Lys Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Thr Ala Gly Trp Phe Gly Glu Ser Val His Leu Asp Ser Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120     


<210> 51
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H1

<400> 51
Gly Thr Phe Asn Ser Gln Ala Ile His 
1               5                   


<210> 52
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H1

<400> 52
ggcaccttca acagtcaagc aattcac                                           27


<210> 53
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H2

<400> 53
Asn Ile Ile Pro Gly Phe Gly Ser Pro Asn Ser Ala Gln Asn Phe Gln 
1               5                   10                  15      


Gly 
    


<210> 54
<211> 51
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H2

<400> 54
aacatcatcc ctgggttcgg atcaccaaac tccgcgcaga acttccaggg c                51


<210> 55
<211> 14
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H3

<400> 55
Ala Thr Ala Gly Trp Phe Gly Glu Ser Val His Leu Asp Ser 
1               5                   10                  


<210> 56
<211> 42
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H3

<400> 56
gcgacagccg ggtggttcgg ggaatcagtt catttggact ca                          42


<210> 57
<211> 324
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region

<400> 57
gatattgtga tgactcagtc tccagccacc ctgtctgtgt ctccagggga aagagccacc       60

ctctcctgca gggccagtga gagtgttagc agcaacttag cctggtacca gcagaaacct      120

ggccaggctc ccaggctcct catctatggt gcatccacca gggccactgg tatcccagcc      180

aggttcagtg gcagtgggtc agggacggag ttcactctca ccatcaacag cctgcagtct      240

gaagattttg cagtttatta ctgtcagcag tataataact ggcctcctct cactttcggc      300

ggagggacca aggtggaaat caaa                                             324


<210> 58
<211> 108
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region

<400> 58
Asp Ile Val Met Thr Gln Ser Pro Ala Thr Leu Ser Val Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Glu Ser Val Ser Ser Asn 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 
        35                  40                  45              


Tyr Gly Ala Ser Thr Arg Ala Thr Gly Ile Pro Ala Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Asn Ser Leu Gln Ser 
65                  70                  75                  80  


Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Asn Asn Trp Pro Pro 
                85                  90                  95      


Leu Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105             


<210> 59
<211> 11
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region CDR L1

<400> 59
Arg Ala Ser Glu Ser Val Ser Ser Asn Leu Ala 
1               5                   10      


<210> 60
<211> 33
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region CDR L1

<400> 60
agggccagtg agagtgttag cagcaactta gcc                                    33


<210> 61
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region CDR L2

<400> 61
Gly Ala Ser Thr Arg Ala Thr 
1               5           


<210> 62
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region CDR L2

<400> 62
ggtgcatcca ccagggccac t                                                 21


<210> 63
<211> 10
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region CDR L3

<400> 63
Gln Gln Tyr Asn Asn Trp Pro Pro Leu Thr 
1               5                   10  


<210> 64
<211> 30
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region CDR L3

<400> 64
cagcagtata ataactggcc tcctctcact                                        30


<210> 65
<211> 363
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region

<400> 65
caggtccagc tggtacagtc tggaagtgag gtgaagaagc ctggggcctc ggtgaaggtc       60

tcctgcaagg cctcaggtta caggttttcc aactatggta tcagctgggt gcgacaggcc      120

cctggacaag gcctagagtg gatgggatgg atcagcgctt acaatggaaa cataaagtat      180

ggaaataacc tccagggcag agtcaccgtg accacagaca catccacggc cacggcctac      240

atggaggtga ggagcctgac atctgacgac acggccgtgt attactgtgc gagagatgtc      300

ccagctgacg gggtccactt catggacgtc tggggccaag gaaccctggt caccgtctcc      360

tca                                                                    363


<210> 66
<211> 121
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region

<400> 66
Gln Val Gln Leu Val Gln Ser Gly Ser Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Arg Phe Ser Asn Tyr 
            20                  25                  30          


Gly Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Ser Ala Tyr Asn Gly Asn Ile Lys Tyr Gly Asn Asn Leu 
    50                  55                  60                  


Gln Gly Arg Val Thr Val Thr Thr Asp Thr Ser Thr Ala Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Val Arg Ser Leu Thr Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Val Pro Ala Asp Gly Val His Phe Met Asp Val Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120     


<210> 67
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H1

<400> 67
Tyr Arg Phe Ser Asn Tyr Gly Ile Ser 
1               5                   


<210> 68
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H1

<400> 68
tacaggtttt ccaactatgg tatcagc                                           27


<210> 69
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H2

<400> 69
Trp Ile Ser Ala Tyr Asn Gly Asn Ile Lys Tyr Gly Asn Asn Leu Gln 
1               5                   10                  15      


Gly 
    


<210> 70
<211> 51
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H2

<400> 70
tggatcagcg cttacaatgg aaacataaag tatggaaata acctccaggg c                51


<210> 71
<211> 14
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H3

<400> 71
Ala Arg Asp Val Pro Ala Asp Gly Val His Phe Met Asp Val 
1               5                   10                  


<210> 72
<211> 42
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H3

<400> 72
gcgagagatg tcccagctga cggggtccac ttcatggacg tc                          42


<210> 73
<211> 336
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region

<400> 73
gaaattgtaa tgacacagtc tccactctcc ctgcccgtca cccttggaca gccggcctcc       60

atctcctgca ggtctagtca aagcctcgta cacagtgata ctaacaccta cttgaactgg      120

tttcagcaga ggccaggcca atctccacgg cgcctaattt ataaggtttc taaccgggac      180

tctggggtcc cagacagatt cagcggcagt gggtcaggca ctactttcac actgaaaatc      240

agcagggtgg aggctgagga tgttgggatt tattactgca tgcagggttc acactgggct      300

ccgactttcg gccaggggac caaggtggaa atcaaa                                336


<210> 74
<211> 112
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region

<400> 74
Glu Ile Val Met Thr Gln Ser Pro Leu Ser Leu Pro Val Thr Leu Gly 
1               5                   10                  15      


Gln Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Val His Ser 
            20                  25                  30          


Asp Thr Asn Thr Tyr Leu Asn Trp Phe Gln Gln Arg Pro Gly Gln Ser 
        35                  40                  45              


Pro Arg Arg Leu Ile Tyr Lys Val Ser Asn Arg Asp Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Thr Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Val Gly Ile Tyr Tyr Cys Met Gln Gly 
                85                  90                  95      


Ser His Trp Ala Pro Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105                 110         


<210> 75
<211> 16
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region CDR L1

<400> 75
Arg Ser Ser Gln Ser Leu Val His Ser Asp Thr Asn Thr Tyr Leu Asn 
1               5                   10                  15      


<210> 76
<211> 48
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region CDR L1

<400> 76
aggtctagtc aaagcctcgt acacagtgat actaacacct acttgaac                    48


<210> 77
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region CDR L2

<400> 77
Lys Val Ser Asn Arg Asp Ser 
1               5           


<210> 78
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region CDR L2

<400> 78
aaggtttcta accgggactc t                                                 21


<210> 79
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region CDR L3

<400> 79
Met Gln Gly Ser His Trp Ala Pro Thr 
1               5                   


<210> 80
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region CDR L3

<400> 80
atgcagggtt cacactgggc tccgact                                           27


<210> 81
<211> 378
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region

<400> 81
caggtccagc tggtgcagtc tgggactgag gtgaagaagc ctgggtcctc ggtgaaggtc       60

tcctgcaagg cttctggagg caccttcggc agctacgctg tcatctgggt gcgacaggcc      120

cctggacaag ggcttgaatg gatgggacat ttcatccctg tgtttgctac aacaaacaag      180

gcacagaagt tccagggcag actcaccctt agtacagacg aatctacggg cacagtctac      240

atggagctga gcagcctgag atctgaggac acggccgtct atttctgtgc gaccaagaga      300

tattgtagtg atcccagctg ccatggactc tggtacttcg atctctgggg ccgtggcacc      360

ctggtcactg tctcctca                                                    378


<210> 82
<211> 126
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region

<400> 82
Gln Val Gln Leu Val Gln Ser Gly Thr Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Gly Ser Tyr 
            20                  25                  30          


Ala Val Ile Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly His Phe Ile Pro Val Phe Ala Thr Thr Asn Lys Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Leu Thr Leu Ser Thr Asp Glu Ser Thr Gly Thr Val Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Phe Cys 
                85                  90                  95      


Ala Thr Lys Arg Tyr Cys Ser Asp Pro Ser Cys His Gly Leu Trp Tyr 
            100                 105                 110         


Phe Asp Leu Trp Gly Arg Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125     


<210> 83
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H1

<400> 83
Gly Thr Phe Gly Ser Tyr Ala Val Ile 
1               5                   


<210> 84
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H1

<400> 84
ggcaccttcg gcagctacgc tgtcatc                                           27


<210> 85
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H2

<400> 85
His Phe Ile Pro Val Phe Ala Thr Thr Asn Lys Ala Gln Lys Phe Gln 
1               5                   10                  15      


Gly 
    


<210> 86
<211> 51
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H2

<400> 86
catttcatcc ctgtgtttgc tacaacaaac aaggcacaga agttccaggg c                51


<210> 87
<211> 19
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H3

<400> 87
Ala Thr Lys Arg Tyr Cys Ser Asp Pro Ser Cys His Gly Leu Trp Tyr 
1               5                   10                  15      


Phe Asp Leu 
            


<210> 88
<211> 57
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H3

<400> 88
gcgaccaaga gatattgtag tgatcccagc tgccatggac tctggtactt cgatctc          57


<210> 89
<211> 339
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region

<400> 89
gacatccagt tgacccagtc tccactctcc ctgcccgtca cccctggaga gccggcctcc       60

atctcctgca ggtctagtca gagcctcttg gatagtgatg atggaaacac ctatttggac      120

tggtacctgc agaagccagg gcagtctcca caggtcctga tctatatgct ttcgtatcgg      180

gcctctggag tcccagacag gttcagtggc agtgggtcag gcactgattt cacactagaa      240

atcagcaggg tggaggctga ggatgttgga gtttattact gcatgcaacg tgtagagttt      300

ccttacactt ttggccaggg gaccaagctg gagatcaaa                             339


<210> 90
<211> 113
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region

<400> 90
Asp Ile Gln Leu Thr Gln Ser Pro Leu Ser Leu Pro Val Thr Pro Gly 
1               5                   10                  15      


Glu Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Leu Asp Ser 
            20                  25                  30          


Asp Asp Gly Asn Thr Tyr Leu Asp Trp Tyr Leu Gln Lys Pro Gly Gln 
        35                  40                  45              


Ser Pro Gln Val Leu Ile Tyr Met Leu Ser Tyr Arg Ala Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Glu 
65                  70                  75                  80  


Ile Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Met Gln 
                85                  90                  95      


Arg Val Glu Phe Pro Tyr Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile 
            100                 105                 110         


Lys 
    


<210> 91
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region CDR L1

<400> 91
Arg Ser Ser Gln Ser Leu Leu Asp Ser Asp Asp Gly Asn Thr Tyr Leu 
1               5                   10                  15      


Asp 
    


<210> 92
<211> 51
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region CDR L1

<400> 92
aggtctagtc agagcctctt ggatagtgat gatggaaaca cctatttgga c                51


<210> 93
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region CDR L2

<400> 93
Met Leu Ser Tyr Arg Ala Ser 
1               5           


<210> 94
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region CDR L2

<400> 94
atgctttcgt atcgggcctc t                                                 21


<210> 95
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region CDR L3

<400> 95
Met Gln Arg Val Glu Phe Pro Tyr Thr 
1               5                   


<210> 96
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region CDR L3

<400> 96
atgcaacgtg tagagtttcc ttacact                                           27


<210> 97
<211> 345
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region

<400> 97
caggtccagc tggtgcagtc tgggcctgac gtgaagagac ctggggcctc agtgagagtc       60

tcctgcaagg cttctggata caccttcagc gactactata tgcactgggt gcgacaggcc      120

cctggacagg gtcttgaatg gctggcttgg gtcaacccta gcactggcgc cacacactac      180

tcagagagtt ttcggggctc tatggtcgtt caaagggaca cgtccaccga cacagcctac      240

ctggagctga gtagtctgaa atctgacgac acggccgtct attattgtgc gagaatcggg      300

agtaatgaga tttggggcca ggggacaatg gtcaccgtct cttca                      345


<210> 98
<211> 115
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region

<400> 98
Gln Val Gln Leu Val Gln Ser Gly Pro Asp Val Lys Arg Pro Gly Ala 
1               5                   10                  15      


Ser Val Arg Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Ser Asp Tyr 
            20                  25                  30          


Tyr Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Leu 
        35                  40                  45              


Ala Trp Val Asn Pro Ser Thr Gly Ala Thr His Tyr Ser Glu Ser Phe 
    50                  55                  60                  


Arg Gly Ser Met Val Val Gln Arg Asp Thr Ser Thr Asp Thr Ala Tyr 
65                  70                  75                  80  


Leu Glu Leu Ser Ser Leu Lys Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ile Gly Ser Asn Glu Ile Trp Gly Gln Gly Thr Met Val Thr 
            100                 105                 110         


Val Ser Ser 
        115 


<210> 99
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H1

<400> 99
Tyr Thr Phe Ser Asp Tyr Tyr Met His 
1               5                   


<210> 100
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H1

<400> 100
tacaccttca gcgactacta tatgcac                                           27


<210> 101
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H2

<400> 101
Trp Val Asn Pro Ser Thr Gly Ala Thr His Tyr Ser Glu Ser Phe Arg 
1               5                   10                  15      


Gly 
    


<210> 102
<211> 51
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H2

<400> 102
tgggtcaacc ctagcactgg cgccacacac tactcagaga gttttcgggg c                51


<210> 103
<211> 8
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H3

<400> 103
Ala Arg Ile Gly Ser Asn Glu Ile 
1               5               


<210> 104
<211> 24
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H3

<400> 104
gcgagaatcg ggagtaatga gatt                                              24


<210> 105
<211> 330
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region

<400> 105
cagtctgccc tgactcagcc tgcctccgtg tctgggtctc ctggacagtc gatcaccatc       60

tcctgcgctg gcacttccag tgacattggt ggttggaact atgtctcctg gtaccaacag      120

taccccggcc aagtccccaa actcatcctt tatgaagtca ctgataggcc ctcaggggtt      180

tctcatcgct tctctggctc caagtctggc aacagggcct tccttaccat cactgggctc      240

cgggccgagg acgaggctga ttattactgc tgctcattta cttcttccgg cagtagggtt      300

ttcggcggag ggaccaaggt caccgtccta                                       330


<210> 106
<211> 110
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region

<400> 106
Gln Ser Ala Leu Thr Gln Pro Ala Ser Val Ser Gly Ser Pro Gly Gln 
1               5                   10                  15      


Ser Ile Thr Ile Ser Cys Ala Gly Thr Ser Ser Asp Ile Gly Gly Trp 
            20                  25                  30          


Asn Tyr Val Ser Trp Tyr Gln Gln Tyr Pro Gly Gln Val Pro Lys Leu 
        35                  40                  45              


Ile Leu Tyr Glu Val Thr Asp Arg Pro Ser Gly Val Ser His Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Asn Arg Ala Phe Leu Thr Ile Thr Gly Leu 
65                  70                  75                  80  


Arg Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Cys Ser Phe Thr Ser Ser 
                85                  90                  95      


Gly Ser Arg Val Phe Gly Gly Gly Thr Lys Val Thr Val Leu 
            100                 105                 110 


<210> 107
<211> 14
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region CDR L1

<400> 107
Ala Gly Thr Ser Ser Asp Ile Gly Gly Trp Asn Tyr Val Ser 
1               5                   10                  


<210> 108
<211> 42
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region CDR L1

<400> 108
gctggcactt ccagtgacat tggtggttgg aactatgtct cc                          42


<210> 109
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region CDR L2

<400> 109
Glu Val Thr Asp Arg Pro Ser 
1               5           


<210> 110
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region CDR L2

<400> 110
gaagtcactg ataggccctc a                                                 21


<210> 111
<211> 10
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region CDR L3

<400> 111
Cys Ser Phe Thr Ser Ser Gly Ser Arg Val 
1               5                   10  


<210> 112
<211> 30
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region CDR L3

<400> 112
tgctcattta cttcttccgg cagtagggtt                                        30


<210> 113
<211> 384
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region

<400> 113
gaggtgcagc tgttggagtc tggggctgtg atgaagaggc ctgggtcatc ggtgagggtc       60

tcctgcaggg cttcaggagt cactttgacc accgtttctg tcaactgggt gcgccaggtc      120

cctgggcaag ggcctgagtg gattggaggg atcctcattg ggtttggtaa ggtcagacaa      180

gcccagaaat ttgagaaccg agtcactctg accgcggacg catcaaggaa cacagcatat      240

atggagttga gcggactgac atctgacgac acggccgtct attactgtgc gataatcgac      300

ccccaagatt gtactcgtgc cagctgcttt tgggtcaact ggctcgaccc ctggggccag      360

ggaaccctgg tcaccgtctc ctca                                             384


<210> 114
<211> 128
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region

<400> 114
Glu Val Gln Leu Leu Glu Ser Gly Ala Val Met Lys Arg Pro Gly Ser 
1               5                   10                  15      


Ser Val Arg Val Ser Cys Arg Ala Ser Gly Val Thr Leu Thr Thr Val 
            20                  25                  30          


Ser Val Asn Trp Val Arg Gln Val Pro Gly Gln Gly Pro Glu Trp Ile 
        35                  40                  45              


Gly Gly Ile Leu Ile Gly Phe Gly Lys Val Arg Gln Ala Gln Lys Phe 
    50                  55                  60                  


Glu Asn Arg Val Thr Leu Thr Ala Asp Ala Ser Arg Asn Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Gly Leu Thr Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ile Ile Asp Pro Gln Asp Cys Thr Arg Ala Ser Cys Phe Trp Val 
            100                 105                 110         


Asn Trp Leu Asp Pro Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125             


<210> 115
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H1

<400> 115
Val Thr Leu Thr Thr Val Ser Val Asn 
1               5                   


<210> 116
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H1

<400> 116
gtcactttga ccaccgtttc tgtcaac                                           27


<210> 117
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H2

<400> 117
Gly Ile Leu Ile Gly Phe Gly Lys Val Arg Gln Ala Gln Lys Phe Glu 
1               5                   10                  15      


Asn 
    


<210> 118
<211> 51
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H2

<400> 118
gggatcctca ttgggtttgg taaggtcaga caagcccaga aatttgagaa c                51


<210> 119
<211> 21
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H3

<400> 119
Ala Ile Ile Asp Pro Gln Asp Cys Thr Arg Ala Ser Cys Phe Trp Val 
1               5                   10                  15      


Asn Trp Leu Asp Pro 
            20      


<210> 120
<211> 63
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H3

<400> 120
gcgataatcg acccccaaga ttgtactcgt gccagctgct tttgggtcaa ctggctcgac       60

ccc                                                                     63


<210> 121
<211> 324
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region

<400> 121
gacatccgga tgacccagtc tccaggcacc ctgaccttgt ccccagggga gcgagccacc       60

ctctcctgca gggccagtca gagtattctt agcgggaact tagcctggta ccagcagaaa      120

cctggccagg ctcccaggct cctcatctct gctgcatcca ctagggccac tgacatccca      180

gacaggttca gtggcagtgg gtctgggaca gacttcactc tcaccatcac cagactggag      240

cctcaagatt ttgcagtgta ttactgtcag cagtatgatt cggctccgat caccttcggc      300

caagggacac gactggagat taaa                                             324


<210> 122
<211> 108
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region

<400> 122
Asp Ile Arg Met Thr Gln Ser Pro Gly Thr Leu Thr Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Ile Leu Ser Gly 
            20                  25                  30          


Asn Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu 
        35                  40                  45              


Ile Ser Ala Ala Ser Thr Arg Ala Thr Asp Ile Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Thr Arg Leu Glu 
65                  70                  75                  80  


Pro Gln Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Asp Ser Ala Pro 
                85                  90                  95      


Ile Thr Phe Gly Gln Gly Thr Arg Leu Glu Ile Lys 
            100                 105             


<210> 123
<211> 12
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region CDR L1

<400> 123
Arg Ala Ser Gln Ser Ile Leu Ser Gly Asn Leu Ala 
1               5                   10          


<210> 124
<211> 36
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region CDR L1

<400> 124
agggccagtc agagtattct tagcgggaac ttagcc                                 36


<210> 125
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region CDR L2

<400> 125
Ala Ala Ser Thr Arg Ala Thr 
1               5           


<210> 126
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region CDR L2

<400> 126
gctgcatcca ctagggccac t                                                 21


<210> 127
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region CDR L3

<400> 127
Gln Gln Tyr Asp Ser Ala Pro Ile Thr 
1               5                   


<210> 128
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region CDR L3

<400> 128
cagcagtatg attcggctcc gatcacc                                           27


<210> 129
<211> 378
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region

<400> 129
caggtccagc ttgtgcagtc tggggctgag gtgaagaagc ctgggtcctc ggtgaaggtc       60

tcctgcgagg cttctggaga caccttcacc agttatgcag tcatctgggt gcgccagacc      120

ccaggacaag ggcttgagtt catgggaagt atcatcccta tctttcaaac aataaactac      180

gctccgaagt tccaggggag ggtcacccta agcgcggacg gatccacgag cacagtcttc      240

atggagttgc gaaacctgag atctgaggac acggccatat atttctgtgc gaccaagaga      300

tattgtacta gtcccagctg ccatggactc tggtacttca atctctgggg ccgtggcaca      360

atggtcaccg tctcttca                                                    378


<210> 130
<211> 126
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region

<400> 130
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Glu Ala Ser Gly Asp Thr Phe Thr Ser Tyr 
            20                  25                  30          


Ala Val Ile Trp Val Arg Gln Thr Pro Gly Gln Gly Leu Glu Phe Met 
        35                  40                  45              


Gly Ser Ile Ile Pro Ile Phe Gln Thr Ile Asn Tyr Ala Pro Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Leu Ser Ala Asp Gly Ser Thr Ser Thr Val Phe 
65                  70                  75                  80  


Met Glu Leu Arg Asn Leu Arg Ser Glu Asp Thr Ala Ile Tyr Phe Cys 
                85                  90                  95      


Ala Thr Lys Arg Tyr Cys Thr Ser Pro Ser Cys His Gly Leu Trp Tyr 
            100                 105                 110         


Phe Asn Leu Trp Gly Arg Gly Thr Met Val Thr Val Ser Ser 
        115                 120                 125     


<210> 131
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H1

<400> 131
Asp Thr Phe Thr Ser Tyr Ala Val Ile 
1               5                   


<210> 132
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H1

<400> 132
gacaccttca ccagttatgc agtcatc                                           27


<210> 133
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H2

<400> 133
Ser Ile Ile Pro Ile Phe Gln Thr Ile Asn Tyr Ala Pro Lys Phe Gln 
1               5                   10                  15      


Gly 
    


<210> 134
<211> 51
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H2

<400> 134
agtatcatcc ctatctttca aacaataaac tacgctccga agttccaggg g                51


<210> 135
<211> 19
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H3

<400> 135
Ala Thr Lys Arg Tyr Cys Thr Ser Pro Ser Cys His Gly Leu Trp Tyr 
1               5                   10                  15      


Phe Asn Leu 
            


<210> 136
<211> 57
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H3

<400> 136
gcgaccaaga gatattgtac tagtcccagc tgccatggac tctggtactt caatctc          57


<210> 137
<211> 339
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region

<400> 137
gaaacgacac tcacgcagtc tccaatctcc ctgtccgtca cccctggaga gccggcctcc       60

atctcctgca ggtctagtaa gagcctcttg gatagtgatg atggaaacac ttatttggac      120

tggtacctgc agaagccagg gcagtctcca cagatcctga tctatatgct ttcgtatcgg      180

gcctctggag tcccagacag gttcagtggc agtgggtcag gcactgattt cacactgaaa      240

atcagcaggg tggaggctga ggatgttgga gtttattact gcatgcaacg tatagagtat      300

ccttacactt ttggccaggg gaccaaggtg gagatcaaa                             339


<210> 138
<211> 113
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region

<400> 138
Glu Thr Thr Leu Thr Gln Ser Pro Ile Ser Leu Ser Val Thr Pro Gly 
1               5                   10                  15      


Glu Pro Ala Ser Ile Ser Cys Arg Ser Ser Lys Ser Leu Leu Asp Ser 
            20                  25                  30          


Asp Asp Gly Asn Thr Tyr Leu Asp Trp Tyr Leu Gln Lys Pro Gly Gln 
        35                  40                  45              


Ser Pro Gln Ile Leu Ile Tyr Met Leu Ser Tyr Arg Ala Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys 
65                  70                  75                  80  


Ile Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Met Gln 
                85                  90                  95      


Arg Ile Glu Tyr Pro Tyr Thr Phe Gly Gln Gly Thr Lys Val Glu Ile 
            100                 105                 110         


Lys 
    


<210> 139
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region CDR L1

<400> 139
Arg Ser Ser Lys Ser Leu Leu Asp Ser Asp Asp Gly Asn Thr Tyr Leu 
1               5                   10                  15      


Asp 
    


<210> 140
<211> 51
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region CDR L1

<400> 140
aggtctagta agagcctctt ggatagtgat gatggaaaca cttatttgga c                51


<210> 141
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region CDR L2

<400> 141
Met Leu Ser Tyr Arg Ala Ser 
1               5           


<210> 142
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region CDR L2

<400> 142
atgctttcgt atcgggcctc t                                                 21


<210> 143
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region CDR L3

<400> 143
Met Gln Arg Ile Glu Tyr Pro Tyr Thr 
1               5                   


<210> 144
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region CDR L3

<400> 144
atgcaacgta tagagtatcc ttacact                                           27


<210> 145
<211> 363
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region

<400> 145
caggtgcagc tggtgcaatc tggggctgag atgaagaagc ctgggtcctc ggtgacagtc       60

tcctgcaagg cttctggagt ccccttcacc agttatacct acagctgggt gcgacaggcc      120

cctggacaag ggcttgagtg gatgggaagg gtcctccctg tcataggttc ggcaaagtac      180

ccacagaagt tccagggcac agtcaccatt accgcggaca aatccacgag cacaatatat      240

ttgcaactga gcagcctaag acctgaagac acggccattt atttctgtgc gggaagtcta      300

ctggctgggt acgacaggga atttgactcc tggggccagg gaaccctggt caccgtctcc      360

tca                                                                    363


<210> 146
<211> 121
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region

<400> 146
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Met Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Thr Val Ser Cys Lys Ala Ser Gly Val Pro Phe Thr Ser Tyr 
            20                  25                  30          


Thr Tyr Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Arg Val Leu Pro Val Ile Gly Ser Ala Lys Tyr Pro Gln Lys Phe 
    50                  55                  60                  


Gln Gly Thr Val Thr Ile Thr Ala Asp Lys Ser Thr Ser Thr Ile Tyr 
65                  70                  75                  80  


Leu Gln Leu Ser Ser Leu Arg Pro Glu Asp Thr Ala Ile Tyr Phe Cys 
                85                  90                  95      


Ala Gly Ser Leu Leu Ala Gly Tyr Asp Arg Glu Phe Asp Ser Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120     


<210> 147
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H1

<400> 147
Val Pro Phe Thr Ser Tyr Thr Tyr Ser 
1               5                   


<210> 148
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H1

<400> 148
gtccccttca ccagttatac ctacagc                                           27


<210> 149
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H2

<400> 149
Arg Val Leu Pro Val Ile Gly Ser Ala Lys Tyr Pro Gln Lys Phe Gln 
1               5                   10                  15      


Gly 
    


<210> 150
<211> 51
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H2

<400> 150
agggtcctcc ctgtcatagg ttcggcaaag tacccacaga agttccaggg c                51


<210> 151
<211> 14
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H3

<400> 151
Ala Gly Ser Leu Leu Ala Gly Tyr Asp Arg Glu Phe Asp Ser 
1               5                   10                  


<210> 152
<211> 42
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H3

<400> 152
gcgggaagtc tactggctgg gtacgacagg gaatttgact cc                          42


<210> 153
<211> 321
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region

<400> 153
gacatccaga tgacccagtc tccatcctca ctgtctgcat ctgtgggaga cagaatcacc       60

atcacttgtc gggcgagtca gggtattagc aactggttag cctggtatca gcagaagcca      120

gggaaagccc ctaagtccct gatctatgaa gcatccactt tgcaaagtgg ggtttcatca      180

aggttcagcg gcagtggatc tgggacacac ttcactctca ccatcgccag cctgcagcct      240

gaagattttg caacttatta ctgccaacag tattatattt acccgctcac tttcggcgga      300

gggaccaagc tggagatcaa a                                                321


<210> 154
<211> 107
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region

<400> 154
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Ile Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Ser Asn Trp 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Ser Leu Ile 
        35                  40                  45              


Tyr Glu Ala Ser Thr Leu Gln Ser Gly Val Ser Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr His Phe Thr Leu Thr Ile Ala Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Tyr Ile Tyr Pro Leu 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210> 155
<211> 11
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region CDR L1

<400> 155
Arg Ala Ser Gln Gly Ile Ser Asn Trp Leu Ala 
1               5                   10      


<210> 156
<211> 33
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region CDR L1

<400> 156
cgggcgagtc agggtattag caactggtta gcc                                    33


<210> 157
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region CDR L2

<400> 157
Glu Ala Ser Thr Leu Gln Ser 
1               5           


<210> 158
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region CDR L2

<400> 158
gaagcatcca ctttgcaaag t                                                 21


<210> 159
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region CDR L3

<400> 159
Gln Gln Tyr Tyr Ile Tyr Pro Leu Thr 
1               5                   


<210> 160
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region CDR L3

<400> 160
caacagtatt atatttaccc gctcact                                           27


<210> 161
<211> 360
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region

<400> 161
gaggtgcagc tggtggagtc tgggggaggc ttggtcaagc ctggagggtc cctaaggctc       60

tcctgtgcag cctctggaag ctccttccgt tattcctaca tgagttgggt ccgccaggct      120

ccagggaagg ggctgcagtg ggttgcatct attagtccta gtagcactta tacagactac      180

gcagactctg tgaagggccg aagcaccatc tccagagacc acgacaagat ctctctgcaa      240

gtgaacagcc tgagaggcga cgacacggcc gtgtattatt gtgtgagaca tatgaatttg      300

gtgatggggc cgttcgcctt tgatatctgg ggccgcggga caatggtcac cgtctcttca      360


<210> 162
<211> 120
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region

<400> 162
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ser Ser Phe Arg Tyr Ser 
            20                  25                  30          


Tyr Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Gln Trp Val 
        35                  40                  45              


Ala Ser Ile Ser Pro Ser Ser Thr Tyr Thr Asp Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Ser Thr Ile Ser Arg Asp His Asp Lys Ile Ser Leu Gln 
65                  70                  75                  80  


Val Asn Ser Leu Arg Gly Asp Asp Thr Ala Val Tyr Tyr Cys Val Arg 
                85                  90                  95      


His Met Asn Leu Val Met Gly Pro Phe Ala Phe Asp Ile Trp Gly Arg 
            100                 105                 110         


Gly Thr Met Val Thr Val Ser Ser 
        115                 120 


<210> 163
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H1

<400> 163
Ser Ser Phe Arg Tyr Ser Tyr Met Ser 
1               5                   


<210> 164
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H1

<400> 164
agctccttcc gttattccta catgagt                                           27


<210> 165
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H2

<400> 165
Ser Ile Ser Pro Ser Ser Thr Tyr Thr Asp Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210> 166
<211> 51
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H2

<400> 166
tctattagtc ctagtagcac ttatacagac tacgcagact ctgtgaaggg c                51


<210> 167
<211> 15
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H3

<400> 167
Val Arg His Met Asn Leu Val Met Gly Pro Phe Ala Phe Asp Ile 
1               5                   10                  15  


<210> 168
<211> 45
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H3

<400> 168
gtgagacata tgaatttggt gatggggccg ttcgcctttg atatc                       45


<210> 169
<211> 330
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region

<400> 169
cagtctgtcg tgacgcagcc gccctcattg tctggggccc cagggcagag gatcaccatt       60

tcgtgcactg ggagcagctc caacatcggg gcaggttatg atgtaaactg gtaccagcag      120

cttccaggaa cagcccccaa actcctcatc tatgctaaga ccaatcggcc ctcaggggtc      180

cctgagcgct tctctggttc cgagtctggc acctccgcct ccctggccat cactgggctc      240

cagcctgagg atgaggctga ttattactgc cagtcatatg acaggatcgg aatgtatgtc      300

ttcggaactg ggaccaagct gaccgtccta                                       330


<210> 170
<211> 110
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region

<400> 170
Gln Ser Val Val Thr Gln Pro Pro Ser Leu Ser Gly Ala Pro Gly Gln 
1               5                   10                  15      


Arg Ile Thr Ile Ser Cys Thr Gly Ser Ser Ser Asn Ile Gly Ala Gly 
            20                  25                  30          


Tyr Asp Val Asn Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu 
        35                  40                  45              


Leu Ile Tyr Ala Lys Thr Asn Arg Pro Ser Gly Val Pro Glu Arg Phe 
    50                  55                  60                  


Ser Gly Ser Glu Ser Gly Thr Ser Ala Ser Leu Ala Ile Thr Gly Leu 
65                  70                  75                  80  


Gln Pro Glu Asp Glu Ala Asp Tyr Tyr Cys Gln Ser Tyr Asp Arg Ile 
                85                  90                  95      


Gly Met Tyr Val Phe Gly Thr Gly Thr Lys Leu Thr Val Leu 
            100                 105                 110 


<210> 171
<211> 14
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region CDR L1

<400> 171
Thr Gly Ser Ser Ser Asn Ile Gly Ala Gly Tyr Asp Val Asn 
1               5                   10                  


<210> 172
<211> 42
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region CDR L1

<400> 172
actgggagca gctccaacat cggggcaggt tatgatgtaa ac                          42


<210> 173
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region CDR L2

<400> 173
Ala Lys Thr Asn Arg Pro Ser 
1               5           


<210> 174
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region CDR L2

<400> 174
gctaagacca atcggccctc a                                                 21


<210> 175
<211> 10
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region CDR L3

<400> 175
Gln Ser Tyr Asp Arg Ile Gly Met Tyr Val 
1               5                   10  


<210> 176
<211> 30
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region CDR L3

<400> 176
cagtcatatg acaggatcgg aatgtatgtc                                        30


<210> 177
<211> 384
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region

<400> 177
gaggtgcagc tggtggagtc tgggggagac ttggtaaagc ctggggggtc cctcagactc       60

tcatgtgaag gctctggctt catttttccg aacgcctgga tgagctgggt ccgccaggct      120

ccagggaagg ggctggagtg ggttggccgt attaaaagca acactgacgg tgggacaaca      180

gactacggtg cacccgtgaa aggcagattc accatctcaa gagatgattc aacaaacacg      240

atgtatctgc acatgaacag cctgaagacc gaggacacag ccgtgtattt ctgttccaca      300

ggcccaccct ataagtattt tgatgagact ggttattcgg tcgttgacta ctggggccag      360

ggaaccctgg tcaccgtctc ctca                                             384


<210> 178
<211> 128
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region

<400> 178
Glu Val Gln Leu Val Glu Ser Gly Gly Asp Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Glu Gly Ser Gly Phe Ile Phe Pro Asn Ala 
            20                  25                  30          


Trp Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Gly Arg Ile Lys Ser Asn Thr Asp Gly Gly Thr Thr Asp Tyr Gly Ala 
    50                  55                  60                  


Pro Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Thr Asn Thr 
65                  70                  75                  80  


Met Tyr Leu His Met Asn Ser Leu Lys Thr Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Phe Cys Ser Thr Gly Pro Pro Tyr Lys Tyr Phe Asp Glu Thr Gly Tyr 
            100                 105                 110         


Ser Val Val Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125             


<210> 179
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H1

<400> 179
Phe Ile Phe Pro Asn Ala Trp Met Ser 
1               5                   


<210> 180
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H1

<400> 180
ttcatttttc cgaacgcctg gatgagc                                           27


<210> 181
<211> 19
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H2

<400> 181
Arg Ile Lys Ser Asn Thr Asp Gly Gly Thr Thr Asp Tyr Gly Ala Pro 
1               5                   10                  15      


Val Lys Gly 
            


<210> 182
<211> 57
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H2

<400> 182
cgtattaaaa gcaacactga cggtgggaca acagactacg gtgcacccgt gaaaggc          57


<210> 183
<211> 19
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H3

<400> 183
Ser Thr Gly Pro Pro Tyr Lys Tyr Phe Asp Glu Thr Gly Tyr Ser Val 
1               5                   10                  15      


Val Asp Tyr 
            


<210> 184
<211> 57
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H3

<400> 184
tccacaggcc caccctataa gtattttgat gagactggtt attcggtcgt tgactac          57


<210> 185
<211> 330
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region

<400> 185
tcctatgagc tgacacagcc accctcagcg tctgggaccc ccgggcagag ggtcatcatc       60

tcttgttctg gaagcacgtc caattccgga tataattatt tttactggta tcagcagcgc      120

ccaggaacgg cccccaaact cctcatctat ggcagtgatc agcggccctc aggggtccct      180

gaccgattct ctggttccca gtctggcccc tcagcctccc tggccatcag tgggctccgg      240

tccgaggatg aggctcatta ttactgtgca gcgtgggatg acaacctgag tggtccggtg      300

ttcggcggag ggaccaagct caccgtccta                                       330


<210> 186
<211> 110
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region

<400> 186
Ser Tyr Glu Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln 
1               5                   10                  15      


Arg Val Ile Ile Ser Cys Ser Gly Ser Thr Ser Asn Ser Gly Tyr Asn 
            20                  25                  30          


Tyr Phe Tyr Trp Tyr Gln Gln Arg Pro Gly Thr Ala Pro Lys Leu Leu 
        35                  40                  45              


Ile Tyr Gly Ser Asp Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gln Ser Gly Pro Ser Ala Ser Leu Ala Ile Ser Gly Leu Arg 
65                  70                  75                  80  


Ser Glu Asp Glu Ala His Tyr Tyr Cys Ala Ala Trp Asp Asp Asn Leu 
                85                  90                  95      


Ser Gly Pro Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 110 


<210> 187
<211> 13
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region CDR L1

<400> 187
Ser Gly Ser Thr Ser Asn Ser Gly Tyr Asn Tyr Phe Tyr 
1               5                   10              


<210> 188
<211> 39
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region CDR L1

<400> 188
tctggaagca cgtccaattc cggatataat tatttttac                              39


<210> 189
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region CDR L2

<400> 189
Gly Ser Asp Gln Arg Pro Ser 
1               5           


<210> 190
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region CDR L2

<400> 190
ggcagtgatc agcggccctc a                                                 21


<210> 191
<211> 11
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region CDR L3

<400> 191
Ala Ala Trp Asp Asp Asn Leu Ser Gly Pro Val 
1               5                   10      


<210> 192
<211> 33
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region CDR L3

<400> 192
gcagcgtggg atgacaacct gagtggtccg gtg                                    33


<210> 193
<211> 384
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region

<400> 193
caggtccagc ttgtacagtc tgggggaggc ttggtaaagc ctggggggtc ccgaagactc       60

gcatgtgcag cctctggatt catcttccgc aacgcctgga tgagctgggt ccgccaggct      120

ccagggaagg ggctggagtg ggttggccgg attaaaagga caagtgaagg agggtcagtc      180

gactacgcga cacccgtgca aggcagattc tccatctcaa gagatgattc tagaaacaca      240

ctgtatctac aaatgcacag cctggcaccc gacgacacag ccgtgtatta ctgttccaca      300

ggcccaccct attcttactt tgatagtact ggttattcgg tcgtggacta ctggggccag      360

ggaaccctgg tcaccgtctc ttca                                             384


<210> 194
<211> 128
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region

<400> 194
Gln Val Gln Leu Val Gln Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Arg Arg Leu Ala Cys Ala Ala Ser Gly Phe Ile Phe Arg Asn Ala 
            20                  25                  30          


Trp Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Gly Arg Ile Lys Arg Thr Ser Glu Gly Gly Ser Val Asp Tyr Ala Thr 
    50                  55                  60                  


Pro Val Gln Gly Arg Phe Ser Ile Ser Arg Asp Asp Ser Arg Asn Thr 
65                  70                  75                  80  


Leu Tyr Leu Gln Met His Ser Leu Ala Pro Asp Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Ser Thr Gly Pro Pro Tyr Ser Tyr Phe Asp Ser Thr Gly Tyr 
            100                 105                 110         


Ser Val Val Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125             


<210> 195
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H1

<400> 195
Phe Ile Phe Arg Asn Ala Trp Met Ser 
1               5                   


<210> 196
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H1

<400> 196
ttcatcttcc gcaacgcctg gatgagc                                           27


<210> 197
<211> 19
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H2

<400> 197
Arg Ile Lys Arg Thr Ser Glu Gly Gly Ser Val Asp Tyr Ala Thr Pro 
1               5                   10                  15      


Val Gln Gly 
            


<210> 198
<211> 57
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H2

<400> 198
cggattaaaa ggacaagtga aggagggtca gtcgactacg cgacacccgt gcaaggc          57


<210> 199
<211> 19
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H3

<400> 199
Ser Thr Gly Pro Pro Tyr Ser Tyr Phe Asp Ser Thr Gly Tyr Ser Val 
1               5                   10                  15      


Val Asp Tyr 
            


<210> 200
<211> 57
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H3

<400> 200
tccacaggcc caccctattc ttactttgat agtactggtt attcggtcgt ggactac          57


<210> 201
<211> 330
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region

<400> 201
cagtctgtgt tgacgcagcc gccctcagcg tctgggaccc ccgggcagag ggtcaccatc       60

tcttgttctg caagcagctc caacatcgga gataattatt tctactggta ccaacaactc      120

ccaggaaagg cccccacact cctcatgtat ggtagtgacc agcggtcctc aggggtccct      180

gaccgattct ctggctccca gtctggcacc tctgcctccc tggccatcag tgggctccgg      240

tccgaggatg aagctgctta ttattgtgca gcttgggatg acagcctgag tggtccggtg      300

ttcggcggag gcacccagct gaccgtcctc                                       330


<210> 202
<211> 110
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region

<400> 202
Gln Ser Val Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln 
1               5                   10                  15      


Arg Val Thr Ile Ser Cys Ser Ala Ser Ser Ser Asn Ile Gly Asp Asn 
            20                  25                  30          


Tyr Phe Tyr Trp Tyr Gln Gln Leu Pro Gly Lys Ala Pro Thr Leu Leu 
        35                  40                  45              


Met Tyr Gly Ser Asp Gln Arg Ser Ser Gly Val Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gln Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Arg 
65                  70                  75                  80  


Ser Glu Asp Glu Ala Ala Tyr Tyr Cys Ala Ala Trp Asp Asp Ser Leu 
                85                  90                  95      


Ser Gly Pro Val Phe Gly Gly Gly Thr Gln Leu Thr Val Leu 
            100                 105                 110 


<210> 203
<211> 13
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region CDR L1

<400> 203
Ser Ala Ser Ser Ser Asn Ile Gly Asp Asn Tyr Phe Tyr 
1               5                   10              


<210> 204
<211> 39
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region CDR L1

<400> 204
tctgcaagca gctccaacat cggagataat tatttctac                              39


<210> 205
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region CDR L2

<400> 205
Gly Ser Asp Gln Arg Ser Ser 
1               5           


<210> 206
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region CDR L2

<400> 206
ggtagtgacc agcggtcctc a                                                 21


<210> 207
<211> 11
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region CDR L3

<400> 207
Ala Ala Trp Asp Asp Ser Leu Ser Gly Pro Val 
1               5                   10      


<210> 208
<211> 33
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region CDR L3

<400> 208
gcagcttggg atgacagcct gagtggtccg gtg                                    33


<210> 209
<211> 369
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region

<400> 209
gaggtgcagc tggtggagtc tggggctgag gtgaggaagc ctggggcctc agtgaaggtc       60

tcctgcaagg cttctggata catcttcatt aactactata tacactgggt gcgacaggcc      120

cctggacaag gtcttgagtg gatggggtgg atcaacccta acagtggagc ctcaaaccac      180

gcacagacgt tcgagggcag gatcaccatg accaccgaca cgtccagcaa cacagcctac      240

atggagctga gtagactgag agaggacgac acggccgtct attactgtgc gagatcccag      300

caactgctcg ttatcaccga ttactcctta gactactggg gcctgggaac cctggtcacc      360

gtctcctca                                                              369


<210> 210
<211> 123
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region

<400> 210
Glu Val Gln Leu Val Glu Ser Gly Ala Glu Val Arg Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Ile Phe Ile Asn Tyr 
            20                  25                  30          


Tyr Ile His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Asn Pro Asn Ser Gly Ala Ser Asn His Ala Gln Thr Phe 
    50                  55                  60                  


Glu Gly Arg Ile Thr Met Thr Thr Asp Thr Ser Ser Asn Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Arg Leu Arg Glu Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ser Gln Gln Leu Leu Val Ile Thr Asp Tyr Ser Leu Asp Tyr 
            100                 105                 110         


Trp Gly Leu Gly Thr Leu Val Thr Val Ser Ser 
        115                 120             


<210> 211
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H1

<400> 211
Tyr Ile Phe Ile Asn Tyr Tyr Ile His 
1               5                   


<210> 212
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H1

<400> 212
tacatcttca ttaactacta tatacac                                           27


<210> 213
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H2

<400> 213
Trp Ile Asn Pro Asn Ser Gly Ala Ser Asn His Ala Gln Thr Phe Glu 
1               5                   10                  15      


Gly 
    


<210> 214
<211> 51
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H2

<400> 214
tggatcaacc ctaacagtgg agcctcaaac cacgcacaga cgttcgaggg c                51


<210> 215
<211> 16
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H3

<400> 215
Ala Arg Ser Gln Gln Leu Leu Val Ile Thr Asp Tyr Ser Leu Asp Tyr 
1               5                   10                  15      


<210> 216
<211> 48
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H3

<400> 216
gcgagatccc agcaactgct cgttatcacc gattactcct tagactac                    48


<210> 217
<211> 324
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region

<400> 217
tcctctgagc tgactcagga ccctgctgtg tctgtggcct tgggacagac agtcaggatc       60

acatgccacg gagacaccct cagaaactat tatccagcct ggtaccagca gaagccagga      120

caggcccctg ttcttgtcgt gtctgataga aacacccggc cctcagggat cccagaccga      180

ttctctgtct ccacctcagg aaacacagct tccttgacca tcactggggc tcaggcggaa      240

gatgagggtg actattactg taactgccgc gacagcagtg gtcaccggct ggtcttcggc      300

ggagggacca agctgaccgt ccta                                             324


<210> 218
<211> 108
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region

<400> 218
Ser Ser Glu Leu Thr Gln Asp Pro Ala Val Ser Val Ala Leu Gly Gln 
1               5                   10                  15      


Thr Val Arg Ile Thr Cys His Gly Asp Thr Leu Arg Asn Tyr Tyr Pro 
            20                  25                  30          


Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Val Leu Val Val Ser 
        35                  40                  45              


Asp Arg Asn Thr Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser Val Ser 
    50                  55                  60                  


Thr Ser Gly Asn Thr Ala Ser Leu Thr Ile Thr Gly Ala Gln Ala Glu 
65                  70                  75                  80  


Asp Glu Gly Asp Tyr Tyr Cys Asn Cys Arg Asp Ser Ser Gly His Arg 
                85                  90                  95      


Leu Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105             


<210> 219
<211> 11
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region CDR L1

<400> 219
His Gly Asp Thr Leu Arg Asn Tyr Tyr Pro Ala 
1               5                   10      


<210> 220
<211> 33
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region CDR L1

<400> 220
cacggagaca ccctcagaaa ctattatcca gcc                                    33


<210> 221
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region CDR L2

<400> 221
Asp Arg Asn Thr Arg Pro Ser 
1               5           


<210> 222
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region CDR L2

<400> 222
gatagaaaca cccggccctc a                                                 21


<210> 223
<211> 11
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region CDR L3

<400> 223
Asn Cys Arg Asp Ser Ser Gly His Arg Leu Val 
1               5                   10      


<210> 224
<211> 33
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region CDR L3

<400> 224
aactgccgcg acagcagtgg tcaccggctg gtc                                    33


<210> 225
<211> 378
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region

<400> 225
caggtccagc ttgtgcagtc tggggctgag gtgaagaagc ctgggtcctc ggtgaaggtc       60

tcctgcgagg cttctggaga caccttcacc agttatgcag tcatctgggt gcgccaggcc      120

ccaggacaag ggcttgagtg gatgggaagt atcatcccta tctttcaaac aatcaactac      180

gcaccaaagt tccaggggag ggtcacccta agcgcggacg gatctacgag aacagtctac      240

atggagttgg gaagcctgag atcagaggac acggccatat atttctgtgc gaccaagaga      300

tactgtacta gtcccagctg ccatggactc tggtacttca atctctgggg ccgtggaacc      360

ctggtcaccg tctcctca                                                    378


<210> 226
<211> 126
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region

<400> 226
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Glu Ala Ser Gly Asp Thr Phe Thr Ser Tyr 
            20                  25                  30          


Ala Val Ile Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Ser Ile Ile Pro Ile Phe Gln Thr Ile Asn Tyr Ala Pro Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Leu Ser Ala Asp Gly Ser Thr Arg Thr Val Tyr 
65                  70                  75                  80  


Met Glu Leu Gly Ser Leu Arg Ser Glu Asp Thr Ala Ile Tyr Phe Cys 
                85                  90                  95      


Ala Thr Lys Arg Tyr Cys Thr Ser Pro Ser Cys His Gly Leu Trp Tyr 
            100                 105                 110         


Phe Asn Leu Trp Gly Arg Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125     


<210> 227
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H1

<400> 227
Asp Thr Phe Thr Ser Tyr Ala Val Ile 
1               5                   


<210> 228
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H1

<400> 228
gacaccttca ccagttatgc agtcatc                                           27


<210> 229
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H2

<400> 229
Ser Ile Ile Pro Ile Phe Gln Thr Ile Asn Tyr Ala Pro Lys Phe Gln 
1               5                   10                  15      


Gly 
    


<210> 230
<211> 51
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H2

<400> 230
agtatcatcc ctatctttca aacaatcaac tacgcaccaa agttccaggg g                51


<210> 231
<211> 19
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H3

<400> 231
Ala Thr Lys Arg Tyr Cys Thr Ser Pro Ser Cys His Gly Leu Trp Tyr 
1               5                   10                  15      


Phe Asn Leu 
            


<210> 232
<211> 57
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H3

<400> 232
gcgaccaaga gatactgtac tagtcccagc tgccatggac tctggtactt caatctc          57


<210> 233
<211> 339
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region

<400> 233
gatattgtga tgacccagtc tccactctcc ctgcccgtca cccctggaga gccggcctcc       60

atctcctgca ggtctagtaa gagcctcttg gatagtgatg atggaaacac ctatttggac      120

tggtacctgc agaagccagg gcagtctcca cagatcctga tctatatgct ttcgcatcgg      180

gcctctggag tcccagacag gttcagtggc agtgggtcag gcactgactt cacactgaaa      240

atcagtaggg tggaggctga ggatgttgga gtttattact gcatgcaacg tgtagagtat      300

ccttacagtt ttggccaggg gaccaaggtg gagatcaaa                             339


<210> 234
<211> 113
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region

<400> 234
Asp Ile Val Met Thr Gln Ser Pro Leu Ser Leu Pro Val Thr Pro Gly 
1               5                   10                  15      


Glu Pro Ala Ser Ile Ser Cys Arg Ser Ser Lys Ser Leu Leu Asp Ser 
            20                  25                  30          


Asp Asp Gly Asn Thr Tyr Leu Asp Trp Tyr Leu Gln Lys Pro Gly Gln 
        35                  40                  45              


Ser Pro Gln Ile Leu Ile Tyr Met Leu Ser His Arg Ala Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys 
65                  70                  75                  80  


Ile Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Met Gln 
                85                  90                  95      


Arg Val Glu Tyr Pro Tyr Ser Phe Gly Gln Gly Thr Lys Val Glu Ile 
            100                 105                 110         


Lys 
    


<210> 235
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region CDR L1

<400> 235
Arg Ser Ser Lys Ser Leu Leu Asp Ser Asp Asp Gly Asn Thr Tyr Leu 
1               5                   10                  15      


Asp 
    


<210> 236
<211> 51
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region CDR L1

<400> 236
aggtctagta agagcctctt ggatagtgat gatggaaaca cctatttgga c                51


<210> 237
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region CDR L2

<400> 237
Met Leu Ser His Arg Ala Ser 
1               5           


<210> 238
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region CDR L2

<400> 238
atgctttcgc atcgggcctc t                                                 21


<210> 239
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region CDR L3

<400> 239
Met Gln Arg Val Glu Tyr Pro Tyr Ser 
1               5                   


<210> 240
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region CDR L3

<400> 240
atgcaacgtg tagagtatcc ttacagt                                           27


<210> 241
<211> 378
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region

<400> 241
cagatcacct tgaaggagtc tgggcctacc gtggtgaaac ccacacagac cctcacactg       60

acctgcacct tctctgggtt ctcactcaac actcgtggca tgggtgtggc ctggatccgt      120

cagcccccag gaggggccct ggagtggctt gcactcgttg attgggatga tgataagcgc      180

tacagccctt ctctgaggag caggctcacc atcaccaaag acacgtccaa gaaccaggtg      240

ctctttacaa tgaccaccat ggaccccgcg gacacagcca cgtactactg tgcacacatc      300

ggtctttatg atcgtggtgg ctattactta ttctactttg acttttgggg ccagggaacc      360

ctggtcaccg tctcctca                                                    378


<210> 242
<211> 126
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region

<400> 242
Gln Ile Thr Leu Lys Glu Ser Gly Pro Thr Val Val Lys Pro Thr Gln 
1               5                   10                  15      


Thr Leu Thr Leu Thr Cys Thr Phe Ser Gly Phe Ser Leu Asn Thr Arg 
            20                  25                  30          


Gly Met Gly Val Ala Trp Ile Arg Gln Pro Pro Gly Gly Ala Leu Glu 
        35                  40                  45              


Trp Leu Ala Leu Val Asp Trp Asp Asp Asp Lys Arg Tyr Ser Pro Ser 
    50                  55                  60                  


Leu Arg Ser Arg Leu Thr Ile Thr Lys Asp Thr Ser Lys Asn Gln Val 
65                  70                  75                  80  


Leu Phe Thr Met Thr Thr Met Asp Pro Ala Asp Thr Ala Thr Tyr Tyr 
                85                  90                  95      


Cys Ala His Ile Gly Leu Tyr Asp Arg Gly Gly Tyr Tyr Leu Phe Tyr 
            100                 105                 110         


Phe Asp Phe Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125     


<210> 243
<211> 11
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H1

<400> 243
Phe Ser Leu Asn Thr Arg Gly Met Gly Val Ala 
1               5                   10      


<210> 244
<211> 33
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H1

<400> 244
ttctcactca acactcgtgg catgggtgtg gcc                                    33


<210> 245
<211> 16
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H2

<400> 245
Leu Val Asp Trp Asp Asp Asp Lys Arg Tyr Ser Pro Ser Leu Arg Ser 
1               5                   10                  15      


<210> 246
<211> 48
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H2

<400> 246
ctcgttgatt gggatgatga taagcgctac agcccttctc tgaggagc                    48


<210> 247
<211> 18
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H3

<400> 247
Ala His Ile Gly Leu Tyr Asp Arg Gly Gly Tyr Tyr Leu Phe Tyr Phe 
1               5                   10                  15      


Asp Phe 
        


<210> 248
<211> 54
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H3

<400> 248
gcacacatcg gtctttatga tcgtggtggc tattacttat tctactttga cttt             54


<210> 249
<211> 321
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region

<400> 249
gatattgtgc tgacgcagtc tccatcctcc ctgtctgcgt ctgtaggcga cagggtcacc       60

atcacttgcc gggcaagtca gagcattgcc agctatgtga attggtttca gcagaaacca      120

gggaaagccc ctgtcctctt gatgtttgct tcatccattt tgcaaagtgg cgtcccgcca      180

aggttccgtg gcagtggatc tgggacagat ttcactctca ccatcaccag tctccagcct      240

gaagattttg caacttacta ctgtcaacac acttacacca ccccgtacat ttttggccgg      300

gggaccaaag tggagatcaa a                                                321


<210> 250
<211> 107
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region

<400> 250
Asp Ile Val Leu Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ala Ser Tyr 
            20                  25                  30          


Val Asn Trp Phe Gln Gln Lys Pro Gly Lys Ala Pro Val Leu Leu Met 
        35                  40                  45              


Phe Ala Ser Ser Ile Leu Gln Ser Gly Val Pro Pro Arg Phe Arg Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Thr Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln His Thr Tyr Thr Thr Pro Tyr 
                85                  90                  95      


Ile Phe Gly Arg Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210> 251
<211> 11
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region CDR L1

<400> 251
Arg Ala Ser Gln Ser Ile Ala Ser Tyr Val Asn 
1               5                   10      


<210> 252
<211> 33
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region CDR L1

<400> 252
cgggcaagtc agagcattgc cagctatgtg aat                                    33


<210> 253
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region CDR L2

<400> 253
Ala Ser Ser Ile Leu Gln Ser 
1               5           


<210> 254
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region CDR L2

<400> 254
gcttcatcca ttttgcaaag t                                                 21


<210> 255
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region CDR L3

<400> 255
Gln His Thr Tyr Thr Thr Pro Tyr Ile 
1               5                   


<210> 256
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region CDR L3

<400> 256
caacacactt acaccacccc gtacatt                                           27


<210> 257
<211> 378
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region

<400> 257
caggtccagc ttgtgcagtc tggtcctacg ctggtgaaac ccacacagac cctcacgctg       60

acctgcacct tctctggctt ctcactcagc actcgtggag tgggtgtggg ctggatccgt      120

cagcccccag gaaaggccct ggagtgcctt ggattcactt attgggatgg tgatcagttc      180

cacagcccat ctctgaagaa cagactcacc attaccaagg acacctccaa aaaccaggtg      240

gtccttagaa tgaccaacat ggaccctgtg gacacggcca cctatttctg tgtacacagc      300

gatctctatg atagtggtgg ttattacttg tactactttg actactgggg ccagggaacc      360

ctggtcaccg tctcctca                                                    378


<210> 258
<211> 126
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region

<400> 258
Gln Val Gln Leu Val Gln Ser Gly Pro Thr Leu Val Lys Pro Thr Gln 
1               5                   10                  15      


Thr Leu Thr Leu Thr Cys Thr Phe Ser Gly Phe Ser Leu Ser Thr Arg 
            20                  25                  30          


Gly Val Gly Val Gly Trp Ile Arg Gln Pro Pro Gly Lys Ala Leu Glu 
        35                  40                  45              


Cys Leu Gly Phe Thr Tyr Trp Asp Gly Asp Gln Phe His Ser Pro Ser 
    50                  55                  60                  


Leu Lys Asn Arg Leu Thr Ile Thr Lys Asp Thr Ser Lys Asn Gln Val 
65                  70                  75                  80  


Val Leu Arg Met Thr Asn Met Asp Pro Val Asp Thr Ala Thr Tyr Phe 
                85                  90                  95      


Cys Val His Ser Asp Leu Tyr Asp Ser Gly Gly Tyr Tyr Leu Tyr Tyr 
            100                 105                 110         


Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125     


<210> 259
<211> 11
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H1

<400> 259
Phe Ser Leu Ser Thr Arg Gly Val Gly Val Gly 
1               5                   10      


<210> 260
<211> 33
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H1

<400> 260
ttctcactca gcactcgtgg agtgggtgtg ggc                                    33


<210> 261
<211> 16
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H2

<400> 261
Phe Thr Tyr Trp Asp Gly Asp Gln Phe His Ser Pro Ser Leu Lys Asn 
1               5                   10                  15      


<210> 262
<211> 48
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H2

<400> 262
ttcacttatt gggatggtga tcagttccac agcccatctc tgaagaac                    48


<210> 263
<211> 18
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H3

<400> 263
Val His Ser Asp Leu Tyr Asp Ser Gly Gly Tyr Tyr Leu Tyr Tyr Phe 
1               5                   10                  15      


Asp Tyr 
        


<210> 264
<211> 54
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H3

<400> 264
gtacacagcg atctctatga tagtggtggt tattacttgt actactttga ctac             54


<210> 265
<211> 321
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region

<400> 265
gacatccaga tgacccagtc tccatcctcc ctgtctgctt ctgtggggga cagagtcacc       60

atcacttgcc gagccagtca gaccattgcc agttatttaa attggtatca gcaaagacca      120

ggggaagccc ctaaactctt gatctatgct gcttccagtt tgcagagtgg ggtctcatca      180

agattcagtg gcaggggatc tgggacagat ttcactctca ccatcaatat tctacaacct      240

gaggatcttg caacttactt ctgtcaacag gcttactctg ccccgtacac ttttggccag      300

gggaccaagg tggaaatcaa a                                                321


<210> 266
<211> 107
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region

<400> 266
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Thr Ile Ala Ser Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Arg Pro Gly Glu Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Ser Ser Arg Phe Ser Gly 
    50                  55                  60                  


Arg Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Asn Ile Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Leu Ala Thr Tyr Phe Cys Gln Gln Ala Tyr Ser Ala Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210> 267
<211> 11
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region CDR L1

<400> 267
Arg Ala Ser Gln Thr Ile Ala Ser Tyr Leu Asn 
1               5                   10      


<210> 268
<211> 33
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region CDR L1

<400> 268
cgagccagtc agaccattgc cagttattta aat                                    33


<210> 269
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region CDR L2

<400> 269
Ala Ala Ser Ser Leu Gln Ser 
1               5           


<210> 270
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region CDR L2

<400> 270
gctgcttcca gtttgcagag t                                                 21


<210> 271
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region CDR L3

<400> 271
Gln Gln Ala Tyr Ser Ala Pro Tyr Thr 
1               5                   


<210> 272
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region CDR L3

<400> 272
caacaggctt actctgcccc gtacact                                           27


<210> 273
<211> 363
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region

<400> 273
caggtccagc tggtacagtc tggagctgag gtgaagaagc ctggggcctc agtgaaggtc       60

tcctgcaagg cttctggtta cacctttacc agctatggta ccagctgggt gcgacaggcc      120

cctggacaag ggcttgagtg gatgggatgg atcagcgctt acaatggtaa cacaaactat      180

gcacagaatc tccagggcag agtcaccatg accacagaca catcaacgag cacatcctac      240

atggagctga ggagcctgag atctgacgac acggccgtgt attactgtgc gagagatgtc      300

cccgtcatag cagctggtac aatggactac tggggccagg gaaccctggt caccgtctcc      360

tca                                                                    363


<210> 274
<211> 121
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region

<400> 274
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Gly Thr Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Ser Ala Tyr Asn Gly Asn Thr Asn Tyr Ala Gln Asn Leu 
    50                  55                  60                  


Gln Gly Arg Val Thr Met Thr Thr Asp Thr Ser Thr Ser Thr Ser Tyr 
65                  70                  75                  80  


Met Glu Leu Arg Ser Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Val Pro Val Ile Ala Ala Gly Thr Met Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120     


<210> 275
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H1

<400> 275
Tyr Thr Phe Thr Ser Tyr Gly Thr Ser 
1               5                   


<210> 276
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H1

<400> 276
tacaccttta ccagctatgg taccagc                                           27


<210> 277
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H2

<400> 277
Trp Ile Ser Ala Tyr Asn Gly Asn Thr Asn Tyr Ala Gln Asn Leu Gln 
1               5                   10                  15      


Gly 
    


<210> 278
<211> 51
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H2

<400> 278
tggatcagcg cttacaatgg taacacaaac tatgcacaga atctccaggg c                51


<210> 279
<211> 14
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H3

<400> 279
Ala Arg Asp Val Pro Val Ile Ala Ala Gly Thr Met Asp Tyr 
1               5                   10                  


<210> 280
<211> 42
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H3

<400> 280
gcgagagatg tccccgtcat agcagctggt acaatggact ac                          42


<210> 281
<211> 336
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region

<400> 281
gatattgtga tgacccagac tccactctcc ctgcccgtca cccttggaca gccggcctcc       60

atctcctgca ggtctagtca aagcctcgta tacagtgatg gaaacaccta cttgaattgg      120

tttcagcaga ggccaggcca atctccaagg cgcctaattt ataaggtttc taatcgggac      180

tctggggtcc cagacagatt cagcggcagt gggtcaggca ctgatttcac actgaaaatc      240

agcagggtgg aggctgagga tgttggggtt tattactgca tgcaaggtcc acactggcct      300

cgaacgttcg gccaagggac caaggtggaa atcaaa                                336


<210> 282
<211> 112
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region

<400> 282
Asp Ile Val Met Thr Gln Thr Pro Leu Ser Leu Pro Val Thr Leu Gly 
1               5                   10                  15      


Gln Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Val Tyr Ser 
            20                  25                  30          


Asp Gly Asn Thr Tyr Leu Asn Trp Phe Gln Gln Arg Pro Gly Gln Ser 
        35                  40                  45              


Pro Arg Arg Leu Ile Tyr Lys Val Ser Asn Arg Asp Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Met Gln Gly 
                85                  90                  95      


Pro His Trp Pro Arg Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105                 110         


<210> 283
<211> 16
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region CDR L1

<400> 283
Arg Ser Ser Gln Ser Leu Val Tyr Ser Asp Gly Asn Thr Tyr Leu Asn 
1               5                   10                  15      


<210> 284
<211> 48
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region CDR L1

<400> 284
aggtctagtc aaagcctcgt atacagtgat ggaaacacct acttgaat                    48


<210> 285
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region CDR L2

<400> 285
Lys Val Ser Asn Arg Asp Ser 
1               5           


<210> 286
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region CDR L2

<400> 286
aaggtttcta atcgggactc t                                                 21


<210> 287
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region CDR L3

<400> 287
Met Gln Gly Pro His Trp Pro Arg Thr 
1               5                   


<210> 288
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region CDR L3

<400> 288
atgcaaggtc cacactggcc tcgaacg                                           27


<210> 289
<211> 372
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region

<400> 289
caggtccagc ttgtgcagtc tggggctgag gtgaagaagc ctggggcctc agtgaaagtc       60

tcgtgtgagg cctctgaata cagtttcagt ggcgactatg ttcactgggt gcgacaggcc      120

cctggacaag ggcttgagtg gatgggttgg ataaaggctg tcaatggtgg cgcgaactac      180

gcacagaagt ttcacggcag ggtcacaatg accactgact cgtccaagag cacagtctat      240

ttggagatga gcagactgac acctgccgac acggccattt atttttgtgc gaaggatcgg      300

gctgcaagtg ttcatgtgcc agcgggcgcg tttgacctct ggggccaggg aaccctggtc      360

accgtctcct ca                                                          372


<210> 290
<211> 124
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region

<400> 290
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Glu Ala Ser Glu Tyr Ser Phe Ser Gly Asp 
            20                  25                  30          


Tyr Val His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Lys Ala Val Asn Gly Gly Ala Asn Tyr Ala Gln Lys Phe 
    50                  55                  60                  


His Gly Arg Val Thr Met Thr Thr Asp Ser Ser Lys Ser Thr Val Tyr 
65                  70                  75                  80  


Leu Glu Met Ser Arg Leu Thr Pro Ala Asp Thr Ala Ile Tyr Phe Cys 
                85                  90                  95      


Ala Lys Asp Arg Ala Ala Ser Val His Val Pro Ala Gly Ala Phe Asp 
            100                 105                 110         


Leu Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 


<210> 291
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H1

<400> 291
Tyr Ser Phe Ser Gly Asp Tyr Val His 
1               5                   


<210> 292
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H1

<400> 292
tacagtttca gtggcgacta tgttcac                                           27


<210> 293
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H2

<400> 293
Trp Ile Lys Ala Val Asn Gly Gly Ala Asn Tyr Ala Gln Lys Phe His 
1               5                   10                  15      


Gly 
    


<210> 294
<211> 51
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H2

<400> 294
tggataaagg ctgtcaatgg tggcgcgaac tacgcacaga agtttcacgg c                51


<210> 295
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H3

<400> 295
Ala Lys Asp Arg Ala Ala Ser Val His Val Pro Ala Gly Ala Phe Asp 
1               5                   10                  15      


Leu 
    


<210> 296
<211> 51
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H3

<400> 296
gcgaaggatc gggctgcaag tgttcatgtg ccagcgggcg cgtttgacct c                51


<210> 297
<211> 324
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region

<400> 297
gacatccaga tgacccagtc tccttcctcc ctgtctgcat atgtaggaga cagagtcagc       60

atcacttgtc gggcaagtca gagcattgac aactttttaa attggtatcg gcagagacca      120

gggaaagccc ctgaactcct aatctatgct gcctccactt tgcaaggtgg ggtcccatca      180

aggttcagtg gcagtggatc tgggacacat ttcactctca ccatcagcag tctccagcct      240

gaagattttg ccacttacta ctgtcaacag agtttcacta ttccttcgat caccttcggc      300

caagggacac gactggagat taaa                                             324


<210> 298
<211> 108
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region

<400> 298
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Tyr Val Gly 
1               5                   10                  15      


Asp Arg Val Ser Ile Thr Cys Arg Ala Ser Gln Ser Ile Asp Asn Phe 
            20                  25                  30          


Leu Asn Trp Tyr Arg Gln Arg Pro Gly Lys Ala Pro Glu Leu Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Thr Leu Gln Gly Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr His Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Phe Thr Ile Pro Ser 
                85                  90                  95      


Ile Thr Phe Gly Gln Gly Thr Arg Leu Glu Ile Lys 
            100                 105             


<210> 299
<211> 11
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region CDR L1

<400> 299
Arg Ala Ser Gln Ser Ile Asp Asn Phe Leu Asn 
1               5                   10      


<210> 300
<211> 33
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region CDR L1

<400> 300
cgggcaagtc agagcattga caacttttta aat                                    33


<210> 301
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region CDR L2

<400> 301
Ala Ala Ser Thr Leu Gln Gly 
1               5           


<210> 302
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region CDR L2

<400> 302
gctgcctcca ctttgcaagg t                                                 21


<210> 303
<211> 10
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region CDR L3

<400> 303
Gln Gln Ser Phe Thr Ile Pro Ser Ile Thr 
1               5                   10  


<210> 304
<211> 30
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region CDR L3

<400> 304
caacagagtt tcactattcc ttcgatcacc                                        30


<210> 305
<211> 378
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region

<400> 305
caggtcacct tgaaggagtc tggtcctgcg ctggtgagac ccaaacagac cctcactctg       60

acctgctcct tctccggctt ctcactcgac actcaaagaa cgggtgtgaa ttggatccgt      120

cagtccccag ggaaggccct ggagtggctt gcacggattg attgggatgg caatatttac      180

tccagcacct ctgtgaggac caaactcagc atctccaagg gcacctccaa aaaccaggtg      240

gtccttacaa tgaccgacgt ggaccctgtg gacacagcca cctattactg tgcacggact      300

ctttactata cttctggtgg ttattacttg aacctctttg actactgggg ccaaggaacc      360

ctggtcaccg tctcctca                                                    378


<210> 306
<211> 126
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region

<400> 306
Gln Val Thr Leu Lys Glu Ser Gly Pro Ala Leu Val Arg Pro Lys Gln 
1               5                   10                  15      


Thr Leu Thr Leu Thr Cys Ser Phe Ser Gly Phe Ser Leu Asp Thr Gln 
            20                  25                  30          


Arg Thr Gly Val Asn Trp Ile Arg Gln Ser Pro Gly Lys Ala Leu Glu 
        35                  40                  45              


Trp Leu Ala Arg Ile Asp Trp Asp Gly Asn Ile Tyr Ser Ser Thr Ser 
    50                  55                  60                  


Val Arg Thr Lys Leu Ser Ile Ser Lys Gly Thr Ser Lys Asn Gln Val 
65                  70                  75                  80  


Val Leu Thr Met Thr Asp Val Asp Pro Val Asp Thr Ala Thr Tyr Tyr 
                85                  90                  95      


Cys Ala Arg Thr Leu Tyr Tyr Thr Ser Gly Gly Tyr Tyr Leu Asn Leu 
            100                 105                 110         


Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125     


<210> 307
<211> 11
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H1

<400> 307
Phe Ser Leu Asp Thr Gln Arg Thr Gly Val Asn 
1               5                   10      


<210> 308
<211> 33
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H1

<400> 308
ttctcactcg acactcaaag aacgggtgtg aat                                    33


<210> 309
<211> 16
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H2

<400> 309
Arg Ile Asp Trp Asp Gly Asn Ile Tyr Ser Ser Thr Ser Val Arg Thr 
1               5                   10                  15      


<210> 310
<211> 48
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H2

<400> 310
cggattgatt gggatggcaa tatttactcc agcacctctg tgaggacc                    48


<210> 311
<211> 18
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H3

<400> 311
Ala Arg Thr Leu Tyr Tyr Thr Ser Gly Gly Tyr Tyr Leu Asn Leu Phe 
1               5                   10                  15      


Asp Tyr 
        


<210> 312
<211> 54
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H3

<400> 312
gcacggactc tttactatac ttctggtggt tattacttga acctctttga ctac             54


<210> 313
<211> 321
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region

<400> 313
gaaattgtaa tgacacagtc tccaccctcc ctgtctgcct ctgttgggga cagagtcacc       60

atcacttgcc gggcaagtca gacaattccc agctatgtca attggtatca gcagatatca      120

gggaaagccc ctcgcctcct gatctatgct gcctcacttt tgcaaagtgg ggtcccatca      180

aggttcagtg gcagcggatc tgggacagag ttcagtctca ccatcagcgg tctgcgacct      240

gaggattttg gcacttacta ctgtcaacag agttacagtt ccactcccac tttcggccag      300

gggaccaagg tggaaatcaa a                                                321


<210> 314
<211> 107
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region

<400> 314
Glu Ile Val Met Thr Gln Ser Pro Pro Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Thr Ile Pro Ser Tyr 
            20                  25                  30          


Val Asn Trp Tyr Gln Gln Ile Ser Gly Lys Ala Pro Arg Leu Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Leu Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Glu Phe Ser Leu Thr Ile Ser Gly Leu Arg Pro 
65                  70                  75                  80  


Glu Asp Phe Gly Thr Tyr Tyr Cys Gln Gln Ser Tyr Ser Ser Thr Pro 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210> 315
<211> 11
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region CDR L1

<400> 315
Arg Ala Ser Gln Thr Ile Pro Ser Tyr Val Asn 
1               5                   10      


<210> 316
<211> 33
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region CDR L1

<400> 316
cgggcaagtc agacaattcc cagctatgtc aat                                    33


<210> 317
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region CDR L2

<400> 317
Ala Ala Ser Leu Leu Gln Ser 
1               5           


<210> 318
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region CDR L2

<400> 318
gctgcctcac ttttgcaaag t                                                 21


<210> 319
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region CDR L3

<400> 319
Gln Gln Ser Tyr Ser Ser Thr Pro Thr 
1               5                   


<210> 320
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region CDR L3

<400> 320
caacagagtt acagttccac tcccact                                           27


<210> 321
<211> 384
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region

<400> 321
caggtgcagc tggtggagtc tgggggaggc ttggtaaagc ctggggggtc cctgagactc       60

tcatgtgcag cctctggatt cattttcagt aacgcctgga tgagttgggt ccgccagtct      120

ccagggaagg ggctggagtg ggttggccgt attaaaacca aaactgaggg tgcgacaaca      180

gaccacgctg cacccctgaa aggcagattc accatctcaa gagatgattc gagaaacaca      240

ctgtatctcc aaatggacag cctgacaacc gaggacacag ccgtgtattt ttgtaccaca      300

ggcccacctt atagttactt tgacagtact gggtattcca tcgttgacta ctggggccag      360

ggaaccctgg tcaccgtctc ctca                                             384


<210> 322
<211> 128
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region

<400> 322
Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ile Phe Ser Asn Ala 
            20                  25                  30          


Trp Met Ser Trp Val Arg Gln Ser Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Gly Arg Ile Lys Thr Lys Thr Glu Gly Ala Thr Thr Asp His Ala Ala 
    50                  55                  60                  


Pro Leu Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Arg Asn Thr 
65                  70                  75                  80  


Leu Tyr Leu Gln Met Asp Ser Leu Thr Thr Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Phe Cys Thr Thr Gly Pro Pro Tyr Ser Tyr Phe Asp Ser Thr Gly Tyr 
            100                 105                 110         


Ser Ile Val Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125             


<210> 323
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H1

<400> 323
Phe Ile Phe Ser Asn Ala Trp Met Ser 
1               5                   


<210> 324
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H1

<400> 324
ttcattttca gtaacgcctg gatgagt                                           27


<210> 325
<211> 19
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H2

<400> 325
Arg Ile Lys Thr Lys Thr Glu Gly Ala Thr Thr Asp His Ala Ala Pro 
1               5                   10                  15      


Leu Lys Gly 
            


<210> 326
<211> 57
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H2

<400> 326
cgtattaaaa ccaaaactga gggtgcgaca acagaccacg ctgcacccct gaaaggc          57


<210> 327
<211> 19
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H3

<400> 327
Thr Thr Gly Pro Pro Tyr Ser Tyr Phe Asp Ser Thr Gly Tyr Ser Ile 
1               5                   10                  15      


Val Asp Tyr 
            


<210> 328
<211> 57
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H3

<400> 328
accacaggcc caccttatag ttactttgac agtactgggt attccatcgt tgactac          57


<210> 329
<211> 330
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region

<400> 329
tcttatgagc tgacacagcc acccgcagcg tctgggaccc ccgggcagag ggtcaccatc       60

tcttgttccg gaagcagctc caacatcgga agtgagtatg tattgtggta tcagcaggtc      120

ccaggaacgg cccccaaact cctcatctat aatagtcatc agcggccctc aggggtccct      180

gaccgcattt ctggctcccg gtctggcacc tctgcctccc tggccatcag tgggctccgg      240

tccgaggatg aggctcatta ttactgtgca tcctgggatg acagcctgag tggtccggtt      300

ttcggcggag ggacccagct gaccgtcctc                                       330


<210> 330
<211> 110
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region

<400> 330
Ser Tyr Glu Leu Thr Gln Pro Pro Ala Ala Ser Gly Thr Pro Gly Gln 
1               5                   10                  15      


Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Ser Glu 
            20                  25                  30          


Tyr Val Leu Trp Tyr Gln Gln Val Pro Gly Thr Ala Pro Lys Leu Leu 
        35                  40                  45              


Ile Tyr Asn Ser His Gln Arg Pro Ser Gly Val Pro Asp Arg Ile Ser 
    50                  55                  60                  


Gly Ser Arg Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Arg 
65                  70                  75                  80  


Ser Glu Asp Glu Ala His Tyr Tyr Cys Ala Ser Trp Asp Asp Ser Leu 
                85                  90                  95      


Ser Gly Pro Val Phe Gly Gly Gly Thr Gln Leu Thr Val Leu 
            100                 105                 110 


<210> 331
<211> 13
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region CDR L1

<400> 331
Ser Gly Ser Ser Ser Asn Ile Gly Ser Glu Tyr Val Leu 
1               5                   10              


<210> 332
<211> 39
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region CDR L1

<400> 332
tccggaagca gctccaacat cggaagtgag tatgtattg                              39


<210> 333
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region CDR L2

<400> 333
Asn Ser His Gln Arg Pro Ser 
1               5           


<210> 334
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region CDR L2

<400> 334
aatagtcatc agcggccctc a                                                 21


<210> 335
<211> 11
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region CDR L3

<400> 335
Ala Ser Trp Asp Asp Ser Leu Ser Gly Pro Val 
1               5                   10      


<210> 336
<211> 33
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region CDR L3

<400> 336
gcatcctggg atgacagcct gagtggtccg gtt                                    33


<210> 337
<211> 384
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region

<400> 337
caggtccagc ttgtacagtc tgggggaggc ttggtaaagc ctggggggtc ccttagactc       60

tcatgtgcag cctctggatt cactttcagt aacgcctgga tgagctgggt ccgccaggct      120

ccagggaagg ggctggactg ggttggccgt atcaaaacca aagctgatgg tgggacaaga      180

gactacgctg cacccgtgaa aggcagattt accatctcga gagatgattc agaaaacacg      240

ttgtatctgc aaatgaccag cctgaaaacc gaggacacag gcgtgtatta ctgtagcaca      300

ggcccaccct ataaatatca tgatagtact ggttattcgg tcgttgacta ctggggccag      360

ggaaccctgg tcactgtctc ctca                                             384


<210> 338
<211> 128
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region

<400> 338
Gln Val Gln Leu Val Gln Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Ala 
            20                  25                  30          


Trp Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Asp Trp Val 
        35                  40                  45              


Gly Arg Ile Lys Thr Lys Ala Asp Gly Gly Thr Arg Asp Tyr Ala Ala 
    50                  55                  60                  


Pro Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Glu Asn Thr 
65                  70                  75                  80  


Leu Tyr Leu Gln Met Thr Ser Leu Lys Thr Glu Asp Thr Gly Val Tyr 
                85                  90                  95      


Tyr Cys Ser Thr Gly Pro Pro Tyr Lys Tyr His Asp Ser Thr Gly Tyr 
            100                 105                 110         


Ser Val Val Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125             


<210> 339
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H1

<400> 339
Phe Thr Phe Ser Asn Ala Trp Met Ser 
1               5                   


<210> 340
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H1

<400> 340
ttcactttca gtaacgcctg gatgagc                                           27


<210> 341
<211> 19
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H2

<400> 341
Arg Ile Lys Thr Lys Ala Asp Gly Gly Thr Arg Asp Tyr Ala Ala Pro 
1               5                   10                  15      


Val Lys Gly 
            


<210> 342
<211> 57
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H2

<400> 342
cgtatcaaaa ccaaagctga tggtgggaca agagactacg ctgcacccgt gaaaggc          57


<210> 343
<211> 19
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H3

<400> 343
Ser Thr Gly Pro Pro Tyr Lys Tyr His Asp Ser Thr Gly Tyr Ser Val 
1               5                   10                  15      


Val Asp Tyr 
            


<210> 344
<211> 57
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H3

<400> 344
agcacaggcc caccctataa atatcatgat agtactggtt attcggtcgt tgactac          57


<210> 345
<211> 330
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region

<400> 345
tcttatgagc tgactcagcc accctcagcg tctgggaccc ccgggcagag ggtcaccatc       60

tcctgttctg gaggcagctc caacatcgga agtgattatg tatactggta ccagcagctc      120

ccaggaacgg cccccaaact cctcatctat ggtagtagtc agcgaccctc aggggtccct      180

gaccgattct ctggctccca gtctggcacc tcagcctccc tggccatcag tggtctccgg      240

tccgaggatg aggctgatta ttactgtgct atgtgggatg acagcctgaa tggtccggtg      300

ttcggcggag ggaccaagct gaccgtccta                                       330


<210> 346
<211> 110
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region

<400> 346
Ser Tyr Glu Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln 
1               5                   10                  15      


Arg Val Thr Ile Ser Cys Ser Gly Gly Ser Ser Asn Ile Gly Ser Asp 
            20                  25                  30          


Tyr Val Tyr Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 
        35                  40                  45              


Ile Tyr Gly Ser Ser Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gln Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Arg 
65                  70                  75                  80  


Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Met Trp Asp Asp Ser Leu 
                85                  90                  95      


Asn Gly Pro Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 110 


<210> 347
<211> 13
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region CDR L1

<400> 347
Ser Gly Gly Ser Ser Asn Ile Gly Ser Asp Tyr Val Tyr 
1               5                   10              


<210> 348
<211> 39
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region CDR L1

<400> 348
tctggaggca gctccaacat cggaagtgat tatgtatac                              39


<210> 349
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region CDR L2

<400> 349
Gly Ser Ser Gln Arg Pro Ser 
1               5           


<210> 350
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region CDR L2

<400> 350
ggtagtagtc agcgaccctc a                                                 21


<210> 351
<211> 11
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region CDR L3

<400> 351
Ala Met Trp Asp Asp Ser Leu Asn Gly Pro Val 
1               5                   10      


<210> 352
<211> 33
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region CDR L3

<400> 352
gctatgtggg atgacagcct gaatggtccg gtg                                    33


<210> 353
<211> 378
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region

<400> 353
caggtgcagc tacagcagtg gggcgcagga ctgttgaagc cttcggagac cctgtccctc       60

tcctgcaccg tctctggtgg ggtcttcggc aattactttt ggagttgggt ccgccaggcc      120

ccagggaagg gcctggaatg gattggagaa atcaatcaga ttggaaccac caactacagt      180

ccgtccgcgt ccctcaagag tcgagtcact atatcagttg acccgtccag gaaccagttc      240

tccctgagcc tgaggtctgt gaccgccgcg gacacggctc ggtattactg tacgagatcc      300

gaaacttcag attactttga tagtagtggt tatgcatttc atatctgggg cgaagggaca      360

atggtcaccg tctcttca                                                    378


<210> 354
<211> 126
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region

<400> 354
Gln Val Gln Leu Gln Gln Trp Gly Ala Gly Leu Leu Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Ser Cys Thr Val Ser Gly Gly Val Phe Gly Asn Tyr 
            20                  25                  30          


Phe Trp Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Glu Ile Asn Gln Ile Gly Thr Thr Asn Tyr Ser Pro Ser Ala Ser 
    50                  55                  60                  


Leu Lys Ser Arg Val Thr Ile Ser Val Asp Pro Ser Arg Asn Gln Phe 
65                  70                  75                  80  


Ser Leu Ser Leu Arg Ser Val Thr Ala Ala Asp Thr Ala Arg Tyr Tyr 
                85                  90                  95      


Cys Thr Arg Ser Glu Thr Ser Asp Tyr Phe Asp Ser Ser Gly Tyr Ala 
            100                 105                 110         


Phe His Ile Trp Gly Glu Gly Thr Met Val Thr Val Ser Ser 
        115                 120                 125     


<210> 355
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H1

<400> 355
Gly Val Phe Gly Asn Tyr Phe Trp Ser 
1               5                   


<210> 356
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H1

<400> 356
ggggtcttcg gcaattactt ttggagt                                           27


<210> 357
<211> 18
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H2

<400> 357
Glu Ile Asn Gln Ile Gly Thr Thr Asn Tyr Ser Pro Ser Ala Ser Leu 
1               5                   10                  15      


Lys Ser 
        


<210> 358
<211> 54
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H2

<400> 358
gaaatcaatc agattggaac caccaactac agtccgtccg cgtccctcaa gagt             54


<210> 359
<211> 18
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H3

<400> 359
Thr Arg Ser Glu Thr Ser Asp Tyr Phe Asp Ser Ser Gly Tyr Ala Phe 
1               5                   10                  15      


His Ile 
        


<210> 360
<211> 54
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H3

<400> 360
acgagatccg aaacttcaga ttactttgat agtagtggtt atgcatttca tatc             54


<210> 361
<211> 327
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region

<400> 361
ctgcctgtgc tgactcagcc tgcctccgtg tctgggtctc ctggacagtc gatcaccatc       60

tcctgcagtg gaatcagcag tgacggtggt cgctataact atgtgtcctg gtaccaacaa      120

cacccgggca aagcccccaa actcctcatc tatgatgaca gtaattggcc tttaggggtt      180

tctcatcgct tctctgggtc caagtctggc aacacggcct ccctgaccat ctctgggctc      240

cgggctgagg acgaggcgga ctattattgc ggctcatata cggacaccaa cagactcttc      300

ggcggaggca cccagctgac cgtcctc                                          327


<210> 362
<211> 109
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region

<400> 362
Leu Pro Val Leu Thr Gln Pro Ala Ser Val Ser Gly Ser Pro Gly Gln 
1               5                   10                  15      


Ser Ile Thr Ile Ser Cys Ser Gly Ile Ser Ser Asp Gly Gly Arg Tyr 
            20                  25                  30          


Asn Tyr Val Ser Trp Tyr Gln Gln His Pro Gly Lys Ala Pro Lys Leu 
        35                  40                  45              


Leu Ile Tyr Asp Asp Ser Asn Trp Pro Leu Gly Val Ser His Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Asn Thr Ala Ser Leu Thr Ile Ser Gly Leu 
65                  70                  75                  80  


Arg Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Gly Ser Tyr Thr Asp Thr 
                85                  90                  95      


Asn Arg Leu Phe Gly Gly Gly Thr Gln Leu Thr Val Leu 
            100                 105                 


<210> 363
<211> 14
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region CDR L1

<400> 363
Ser Gly Ile Ser Ser Asp Gly Gly Arg Tyr Asn Tyr Val Ser 
1               5                   10                  


<210> 364
<211> 42
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region CDR L1

<400> 364
agtggaatca gcagtgacgg tggtcgctat aactatgtgt cc                          42


<210> 365
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region CDR L2

<400> 365
Asp Asp Ser Asn Trp Pro Leu 
1               5           


<210> 366
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region CDR L2

<400> 366
gatgacagta attggccttt a                                                 21


<210> 367
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region CDR L3

<400> 367
Gly Ser Tyr Thr Asp Thr Asn Arg Leu 
1               5                   


<210> 368
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region CDR L3

<400> 368
ggctcatata cggacaccaa cagactc                                           27


<210> 369
<211> 351
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region

<400> 369
gaggtgcagc tggtggagtc ggggggaggc gtggtccagc ctgggaggtc cctgagactc       60

tcctgtgcag cctctggatt caccttcagt gaccatgcta tgtactgggt ccgccaggct      120

ccaggcaaag ggctagagtg ggtggcactt atatcatttg atggaaggaa tatatactac      180

gcagactccg tgaagggccg attcaccatc tccagagaca attccaagaa cacgctgtat      240

ctgcagatga acagcctgag agctgaggac acggctgtct attactgtgc gagagatcaa      300

tggctggttc ctgactactg gggccaggga accctggtca ccgtctcctc a               351


<210> 370
<211> 117
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region

<400> 370
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp His 
            20                  25                  30          


Ala Met Tyr Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Leu Ile Ser Phe Asp Gly Arg Asn Ile Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Gln Trp Leu Val Pro Asp Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210> 371
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H1

<400> 371
Phe Thr Phe Ser Asp His Ala Met Tyr 
1               5                   


<210> 372
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H1

<400> 372
ttcaccttca gtgaccatgc tatgtac                                           27


<210> 373
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H2

<400> 373
Leu Ile Ser Phe Asp Gly Arg Asn Ile Tyr Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210> 374
<211> 51
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H2

<400> 374
cttatatcat ttgatggaag gaatatatac tacgcagact ccgtgaaggg c                51


<210> 375
<211> 10
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H3

<400> 375
Ala Arg Asp Gln Trp Leu Val Pro Asp Tyr 
1               5                   10  


<210> 376
<211> 30
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H3

<400> 376
gcgagagatc aatggctggt tcctgactac                                        30


<210> 377
<211> 327
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region

<400> 377
ctgcctgtgc tgactcagcc tgcctccgtg tctgggtctc ctggacagtc gatcaccatc       60

tcctgcactg gaaccagcag tgacgttggt ggttataact atgtctcctg gtaccaacag      120

cacccaggca acgcccccaa actcatgatt tatgaagtca gtaagcggcc ctcaggggtc      180

cctgatcgct tctctggctt caagtctggc aacacggcct ccctgaccgt ctctgggctc      240

caggctgagg atgaggctga ttattactgc agctcatatg caggcagcaa cagtgtcttc      300

ggaactggga ccaagctcac cgtccta                                          327


<210> 378
<211> 109
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region

<400> 378
Leu Pro Val Leu Thr Gln Pro Ala Ser Val Ser Gly Ser Pro Gly Gln 
1               5                   10                  15      


Ser Ile Thr Ile Ser Cys Thr Gly Thr Ser Ser Asp Val Gly Gly Tyr 
            20                  25                  30          


Asn Tyr Val Ser Trp Tyr Gln Gln His Pro Gly Asn Ala Pro Lys Leu 
        35                  40                  45              


Met Ile Tyr Glu Val Ser Lys Arg Pro Ser Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Phe Lys Ser Gly Asn Thr Ala Ser Leu Thr Val Ser Gly Leu 
65                  70                  75                  80  


Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Ser Ser Tyr Ala Gly Ser 
                85                  90                  95      


Asn Ser Val Phe Gly Thr Gly Thr Lys Leu Thr Val Leu 
            100                 105                 


<210> 379
<211> 14
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region CDR L1

<400> 379
Thr Gly Thr Ser Ser Asp Val Gly Gly Tyr Asn Tyr Val Ser 
1               5                   10                  


<210> 380
<211> 42
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region CDR L1

<400> 380
actggaacca gcagtgacgt tggtggttat aactatgtct cc                          42


<210> 381
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region CDR L2

<400> 381
Glu Val Ser Lys Arg Pro Ser 
1               5           


<210> 382
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region CDR L2

<400> 382
gaagtcagta agcggccctc a                                                 21


<210> 383
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region CDR L3

<400> 383
Ser Ser Tyr Ala Gly Ser Asn Ser Val 
1               5                   


<210> 384
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region CDR L3

<400> 384
agctcatatg caggcagcaa cagtgtc                                           27


<210> 385
<211> 366
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region

<400> 385
caggtccagc tggtgcagtc tgggggaggc gtggtccagc ctggggggtc cctgagactc       60

tcctgtgcag cgtatggact caccttcagg gcctatggca tgcactgggt ccgccaggct      120

ccaggcaagg ggctcgagtg ggtggcagtg tcatggtatg acggaacaaa tgaagtctat      180

gcagactcag tgaagggccg cttcagaatc tccagagatg attccaggag cactctatat      240

ttgcaaatga atagtctgag aggcgaggac acggctgtat attactgtgc gacagaaagg      300

atgtgggagg aaaactccag cagcttcggc tggtggggcc ggggaaccct ggtcaccgtc      360

tcctca                                                                 366


<210> 386
<211> 122
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region

<400> 386
Gln Val Gln Leu Val Gln Ser Gly Gly Gly Val Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Tyr Gly Leu Thr Phe Arg Ala Tyr 
            20                  25                  30          


Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Val Ser Trp Tyr Asp Gly Thr Asn Glu Val Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Arg Ile Ser Arg Asp Asp Ser Arg Ser Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Gly Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Thr Glu Arg Met Trp Glu Glu Asn Ser Ser Ser Phe Gly Trp Trp 
            100                 105                 110         


Gly Arg Gly Thr Leu Val Thr Val Ser Ser 
        115                 120         


<210> 387
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H1

<400> 387
Leu Thr Phe Arg Ala Tyr Gly Met His 
1               5                   


<210> 388
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H1

<400> 388
ctcaccttca gggcctatgg catgcac                                           27


<210> 389
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H2

<400> 389
Val Ser Trp Tyr Asp Gly Thr Asn Glu Val Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210> 390
<211> 51
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H2

<400> 390
gtgtcatggt atgacggaac aaatgaagtc tatgcagact cagtgaaggg c                51


<210> 391
<211> 15
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H3

<400> 391
Ala Thr Glu Arg Met Trp Glu Glu Asn Ser Ser Ser Phe Gly Trp 
1               5                   10                  15  


<210> 392
<211> 45
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H3

<400> 392
gcgacagaaa ggatgtggga ggaaaactcc agcagcttcg gctgg                       45


<210> 393
<211> 330
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region

<400> 393
caggctgtgc tgactcagcc tgcctccgtg tctgggtctc ctggacagtc gatcaccatt       60

tcctgcactg gaagcagcag tgacgttggt ggttctaact ttgtctcctg gtaccaacaa      120

cacccaggca aagcccccaa actcatggtt tatgatgtca atcatcggcc ctcagggatt      180

tctaatcgct tctctggctc caagtctggc aacacggcct ccctgaccat ctctgggctc      240

caggctgagg acgaggctga ttattactgc acctcatata caagtagaag ctcttatgtc      300

ttcggaagtg ggaccaaggt gaccgtactt                                       330


<210> 394
<211> 110
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region

<400> 394
Gln Ala Val Leu Thr Gln Pro Ala Ser Val Ser Gly Ser Pro Gly Gln 
1               5                   10                  15      


Ser Ile Thr Ile Ser Cys Thr Gly Ser Ser Ser Asp Val Gly Gly Ser 
            20                  25                  30          


Asn Phe Val Ser Trp Tyr Gln Gln His Pro Gly Lys Ala Pro Lys Leu 
        35                  40                  45              


Met Val Tyr Asp Val Asn His Arg Pro Ser Gly Ile Ser Asn Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Asn Thr Ala Ser Leu Thr Ile Ser Gly Leu 
65                  70                  75                  80  


Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Thr Ser Tyr Thr Ser Arg 
                85                  90                  95      


Ser Ser Tyr Val Phe Gly Ser Gly Thr Lys Val Thr Val Leu 
            100                 105                 110 


<210> 395
<211> 14
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region CDR L1

<400> 395
Thr Gly Ser Ser Ser Asp Val Gly Gly Ser Asn Phe Val Ser 
1               5                   10                  


<210> 396
<211> 42
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region CDR L1

<400> 396
actggaagca gcagtgacgt tggtggttct aactttgtct cc                          42


<210> 397
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region CDR L2

<400> 397
Asp Val Asn His Arg Pro Ser 
1               5           


<210> 398
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region CDR L2

<400> 398
gatgtcaatc atcggccctc a                                                 21


<210> 399
<211> 10
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region CDR L3

<400> 399
Thr Ser Tyr Thr Ser Arg Ser Ser Tyr Val 
1               5                   10  


<210> 400
<211> 30
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region CDR L3

<400> 400
acctcatata caagtagaag ctcttatgtc                                        30


<210> 401
<211> 363
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region

<400> 401
caggtccagc tggtacagtc tggaactgaa gtgaagaagc ctggggcctc agtgaaggtc       60

tcctgtaagg cctctgggta catcttcgac cactttgcta tcacctgggt gcgccaggcc      120

cctggacaag ggcctgagtg gatgggatgg atcagcgctt ataatgggag aacagaggat      180

tcagggaaat tcccgggcag actcaccctg accacagacc ccgccacgcg gacagccttc      240

ctggaactga ggggcctgac acctgacgac acggccgttt attactgtgc gcgagatgtc      300

ccggtcatgg gagccgcatt tttggactac tggggccagg gaaccctggt caccgtctcc      360

tca                                                                    363


<210> 402
<211> 121
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region

<400> 402
Gln Val Gln Leu Val Gln Ser Gly Thr Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Ile Phe Asp His Phe 
            20                  25                  30          


Ala Ile Thr Trp Val Arg Gln Ala Pro Gly Gln Gly Pro Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Ser Ala Tyr Asn Gly Arg Thr Glu Asp Ser Gly Lys Phe 
    50                  55                  60                  


Pro Gly Arg Leu Thr Leu Thr Thr Asp Pro Ala Thr Arg Thr Ala Phe 
65                  70                  75                  80  


Leu Glu Leu Arg Gly Leu Thr Pro Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Val Pro Val Met Gly Ala Ala Phe Leu Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120     


<210> 403
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H1

<400> 403
Tyr Ile Phe Asp His Phe Ala Ile Thr 
1               5                   


<210> 404
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H1

<400> 404
tacatcttcg accactttgc tatcacc                                           27


<210> 405
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H2

<400> 405
Trp Ile Ser Ala Tyr Asn Gly Arg Thr Glu Asp Ser Gly Lys Phe Pro 
1               5                   10                  15      


Gly 
    


<210> 406
<211> 51
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H2

<400> 406
tggatcagcg cttataatgg gagaacagag gattcaggga aattcccggg c                51


<210> 407
<211> 14
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H3

<400> 407
Ala Arg Asp Val Pro Val Met Gly Ala Ala Phe Leu Asp Tyr 
1               5                   10                  


<210> 408
<211> 42
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H3

<400> 408
gcgcgagatg tcccggtcat gggagccgca tttttggact ac                          42


<210> 409
<211> 336
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region

<400> 409
gaaattgtat tgacacagtc tccactctcc ctgcccgtca ctgttggaca gccggcctcc       60

atctcctgca ggtctggcca aagtctcgaa ttcagtgatg gaaacaccta cttgacttgg      120

tttcaccaga ggccaggcca atctccaagg cgcctaattt ataggggttc ttaccgggac      180

tctggggtcc ccgacagatt ccgcggcagt ggctcaggca ctactttcac actgacaatc      240

agcagggtgg aggctgagga tgttgggatt tatttctgca tgcaaggtac acactggcct      300

ccgaccttcg gccaagggac caaagtggat atcaaa                                336


<210> 410
<211> 112
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region

<400> 410
Glu Ile Val Leu Thr Gln Ser Pro Leu Ser Leu Pro Val Thr Val Gly 
1               5                   10                  15      


Gln Pro Ala Ser Ile Ser Cys Arg Ser Gly Gln Ser Leu Glu Phe Ser 
            20                  25                  30          


Asp Gly Asn Thr Tyr Leu Thr Trp Phe His Gln Arg Pro Gly Gln Ser 
        35                  40                  45              


Pro Arg Arg Leu Ile Tyr Arg Gly Ser Tyr Arg Asp Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Arg Gly Ser Gly Ser Gly Thr Thr Phe Thr Leu Thr Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Val Gly Ile Tyr Phe Cys Met Gln Gly 
                85                  90                  95      


Thr His Trp Pro Pro Thr Phe Gly Gln Gly Thr Lys Val Asp Ile Lys 
            100                 105                 110         


<210> 411
<211> 16
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region CDR L1

<400> 411
Arg Ser Gly Gln Ser Leu Glu Phe Ser Asp Gly Asn Thr Tyr Leu Thr 
1               5                   10                  15      


<210> 412
<211> 48
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region CDR L1

<400> 412
aggtctggcc aaagtctcga attcagtgat ggaaacacct acttgact                    48


<210> 413
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region CDR L2

<400> 413
Arg Gly Ser Tyr Arg Asp Ser 
1               5           


<210> 414
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region CDR L2

<400> 414
aggggttctt accgggactc t                                                 21


<210> 415
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region CDR L3

<400> 415
Met Gln Gly Thr His Trp Pro Pro Thr 
1               5                   


<210> 416
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region CDR L3

<400> 416
atgcaaggta cacactggcc tccgacc                                           27


<210> 417
<211> 372
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region

<400> 417
caggtccagc tggtgcagtc tggggctgag gtgaagaagc ctggggcctc agtgaaagtc       60

tcctgtgagg cctctgcata cagtttcagc ggcgactatg ttcactgggt gcgacaggcc      120

cctggacaag ggcttgagtg gatgggttgg ataaaggctg tcaatggtgg cgcaaactat      180

gcacagaggt ttcacggcag ggtcaccatg accactgact cgtccaggag cacagtctat      240

ctggagctga ccaggctgac acctgacgac acggccgttt atttttgtgc gaaagatcga      300

gctgcaagtg ttcatgtgcc agctggtgag tttgacctct ggggccaggg aaccctggtc      360

accgtctcct ca                                                          372


<210> 418
<211> 124
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region

<400> 418
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Glu Ala Ser Ala Tyr Ser Phe Ser Gly Asp 
            20                  25                  30          


Tyr Val His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Lys Ala Val Asn Gly Gly Ala Asn Tyr Ala Gln Arg Phe 
    50                  55                  60                  


His Gly Arg Val Thr Met Thr Thr Asp Ser Ser Arg Ser Thr Val Tyr 
65                  70                  75                  80  


Leu Glu Leu Thr Arg Leu Thr Pro Asp Asp Thr Ala Val Tyr Phe Cys 
                85                  90                  95      


Ala Lys Asp Arg Ala Ala Ser Val His Val Pro Ala Gly Glu Phe Asp 
            100                 105                 110         


Leu Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 


<210> 419
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H1

<400> 419
Tyr Ser Phe Ser Gly Asp Tyr Val His 
1               5                   


<210> 420
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H1

<400> 420
tacagtttca gcggcgacta tgttcac                                           27


<210> 421
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H2

<400> 421
Trp Ile Lys Ala Val Asn Gly Gly Ala Asn Tyr Ala Gln Arg Phe His 
1               5                   10                  15      


Gly 
    


<210> 422
<211> 51
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H2

<400> 422
tggataaagg ctgtcaatgg tggcgcaaac tatgcacaga ggtttcacgg c                51


<210> 423
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H3

<400> 423
Ala Lys Asp Arg Ala Ala Ser Val His Val Pro Ala Gly Glu Phe Asp 
1               5                   10                  15      


Leu 
    


<210> 424
<211> 51
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H3

<400> 424
gcgaaagatc gagctgcaag tgttcatgtg ccagctggtg agtttgacct c                51


<210> 425
<211> 324
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region

<400> 425
gacatccagg tgacccagtc tccttcctcc ctgtctgcat ctgtaggaga cagagtcagc       60

atcacttgtc gggcaagtca gagcattagc aactttttaa attggtatcg gcagagacca      120

gggaaagccc ctgagctcct aatctatgct gcctccactt tgcaaggtgg ggtcccatca      180

aggttcagtg gcagtggatc tgggacacat ttcactctca ccatcagcag tctccagcct      240

gaagattttg caacttacta ctgtcaacag agttacacta ttccttcgat caccttcggc      300

caagggacac gactggagat taaa                                             324


<210> 426
<211> 108
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region

<400> 426
Asp Ile Gln Val Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Ser Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Asn Phe 
            20                  25                  30          


Leu Asn Trp Tyr Arg Gln Arg Pro Gly Lys Ala Pro Glu Leu Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Thr Leu Gln Gly Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr His Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Tyr Thr Ile Pro Ser 
                85                  90                  95      


Ile Thr Phe Gly Gln Gly Thr Arg Leu Glu Ile Lys 
            100                 105             


<210> 427
<211> 11
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region CDR L1

<400> 427
Arg Ala Ser Gln Ser Ile Ser Asn Phe Leu Asn 
1               5                   10      


<210> 428
<211> 33
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region CDR L1

<400> 428
cgggcaagtc agagcattag caacttttta aat                                    33


<210> 429
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region CDR L2

<400> 429
Ala Ala Ser Thr Leu Gln Gly 
1               5           


<210> 430
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region CDR L2

<400> 430
gctgcctcca ctttgcaagg t                                                 21


<210> 431
<211> 10
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region CDR L3

<400> 431
Gln Gln Ser Tyr Thr Ile Pro Ser Ile Thr 
1               5                   10  


<210> 432
<211> 30
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region CDR L3

<400> 432
caacagagtt acactattcc ttcgatcacc                                        30


<210> 433
<211> 366
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region

<400> 433
caggtgcagc tgttggagtc gggcgcagga cttttgaagc cttcggagac cctgtccctc       60

acctgctctt tgtctggtgg gtccttcaga gacttctact gggcctggat tcgccaggcc      120

cccgggaggg ggctggagtg gattggggac atcaatgacg gtggaaacac caaccacagt      180

ccgtccctca agagtcgagc catcctttcc atagacgcgt ccaagaggca gttctccctg      240

agactgacct ctgtgaccgc cgcggacacg gctgtttatt attgcgcgag acagaggctc      300

gaacacacgg catctggata ttacatggac gtctggggca acgggaccac ggtcaccgtc      360

tcctca                                                                 366


<210> 434
<211> 122
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region

<400> 434
Gln Val Gln Leu Leu Glu Ser Gly Ala Gly Leu Leu Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Ser Leu Ser Gly Gly Ser Phe Arg Asp Phe 
            20                  25                  30          


Tyr Trp Ala Trp Ile Arg Gln Ala Pro Gly Arg Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Asp Ile Asn Asp Gly Gly Asn Thr Asn His Ser Pro Ser Leu Lys 
    50                  55                  60                  


Ser Arg Ala Ile Leu Ser Ile Asp Ala Ser Lys Arg Gln Phe Ser Leu 
65                  70                  75                  80  


Arg Leu Thr Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Gln Arg Leu Glu His Thr Ala Ser Gly Tyr Tyr Met Asp Val Trp 
            100                 105                 110         


Gly Asn Gly Thr Thr Val Thr Val Ser Ser 
        115                 120         


<210> 435
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H1

<400> 435
Gly Ser Phe Arg Asp Phe Tyr Trp Ala 
1               5                   


<210> 436
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H1

<400> 436
gggtccttca gagacttcta ctgggcc                                           27


<210> 437
<211> 16
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H2

<400> 437
Asp Ile Asn Asp Gly Gly Asn Thr Asn His Ser Pro Ser Leu Lys Ser 
1               5                   10                  15      


<210> 438
<211> 48
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H2

<400> 438
gacatcaatg acggtggaaa caccaaccac agtccgtccc tcaagagt                    48


<210> 439
<211> 16
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H3

<400> 439
Ala Arg Gln Arg Leu Glu His Thr Ala Ser Gly Tyr Tyr Met Asp Val 
1               5                   10                  15      


<210> 440
<211> 48
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H3

<400> 440
gcgagacaga ggctcgaaca cacggcatct ggatattaca tggacgtc                    48


<210> 441
<211> 324
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region

<400> 441
cagtctgtcc tgacgcagcc gccctcggtg tcagtggacc caggagagac ggccaccatt       60

acctgtggcg gagccaacat tggttctaaa aatgtctact ggtatcagca gaggccaggc      120

caggcccctg tgctggtcgt ctatgatgat atcgaccggc ccgcagggat ccctgatcga      180

ttcactgact ctagttctgg gaacacggtc accctgacca tctacagcgt cgaggccgtg      240

gatgaggccg actatttctg tcaggtgtgg gataattctt ctgatcagcc ggtgttcggc      300

ggagggacca agctcaccgt cctc                                             324


<210> 442
<211> 108
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region

<400> 442
Gln Ser Val Leu Thr Gln Pro Pro Ser Val Ser Val Asp Pro Gly Glu 
1               5                   10                  15      


Thr Ala Thr Ile Thr Cys Gly Gly Ala Asn Ile Gly Ser Lys Asn Val 
            20                  25                  30          


Tyr Trp Tyr Gln Gln Arg Pro Gly Gln Ala Pro Val Leu Val Val Tyr 
        35                  40                  45              


Asp Asp Ile Asp Arg Pro Ala Gly Ile Pro Asp Arg Phe Thr Asp Ser 
    50                  55                  60                  


Ser Ser Gly Asn Thr Val Thr Leu Thr Ile Tyr Ser Val Glu Ala Val 
65                  70                  75                  80  


Asp Glu Ala Asp Tyr Phe Cys Gln Val Trp Asp Asn Ser Ser Asp Gln 
                85                  90                  95      


Pro Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105             


<210> 443
<211> 11
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region CDR L1

<400> 443
Gly Gly Ala Asn Ile Gly Ser Lys Asn Val Tyr 
1               5                   10      


<210> 444
<211> 33
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region CDR L1

<400> 444
ggcggagcca acattggttc taaaaatgtc tac                                    33


<210> 445
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region CDR L2

<400> 445
Asp Asp Ile Asp Arg Pro Ala 
1               5           


<210> 446
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region CDR L2

<400> 446
gatgatatcg accggcccgc a                                                 21


<210> 447
<211> 11
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region CDR L3

<400> 447
Gln Val Trp Asp Asn Ser Ser Asp Gln Pro Val 
1               5                   10      


<210> 448
<211> 33
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region CDR L3

<400> 448
caggtgtggg ataattcttc tgatcagccg gtg                                    33


<210> 449
<211> 357
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region

<400> 449
caggtccagc ttgtgcagtc tggagcagag gcgaaaaagc ccggggagcc tctgaggatc       60

tcctgtaagg gttctggata cacctttagc agctactgga tcagctgggt gcgccagagg      120

cccggggaac gcctggagtg gatggggaga attgatccga gtgactccta tgcctactcg      180

agcccgtcct tccaaggcca cgtcaccttc tcagctgaca agtccagcaa cactgccttt      240

ttgcagtgga gcagcctgca ggcctcggac accgccatct attactgcgc gagacacaaa      300

gagaattacg atttttggga tttctggggc cagggcacaa tggtcaccgt ctcttca         357


<210> 450
<211> 119
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region

<400> 450
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Ala Lys Lys Pro Gly Glu 
1               5                   10                  15      


Pro Leu Arg Ile Ser Cys Lys Gly Ser Gly Tyr Thr Phe Ser Ser Tyr 
            20                  25                  30          


Trp Ile Ser Trp Val Arg Gln Arg Pro Gly Glu Arg Leu Glu Trp Met 
        35                  40                  45              


Gly Arg Ile Asp Pro Ser Asp Ser Tyr Ala Tyr Ser Ser Pro Ser Phe 
    50                  55                  60                  


Gln Gly His Val Thr Phe Ser Ala Asp Lys Ser Ser Asn Thr Ala Phe 
65                  70                  75                  80  


Leu Gln Trp Ser Ser Leu Gln Ala Ser Asp Thr Ala Ile Tyr Tyr Cys 
                85                  90                  95      


Ala Arg His Lys Glu Asn Tyr Asp Phe Trp Asp Phe Trp Gly Gln Gly 
            100                 105                 110         


Thr Met Val Thr Val Ser Ser 
        115                 


<210> 451
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H1

<400> 451
Tyr Thr Phe Ser Ser Tyr Trp Ile Ser 
1               5                   


<210> 452
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H1

<400> 452
tacaccttta gcagctactg gatcagc                                           27


<210> 453
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H2

<400> 453
Arg Ile Asp Pro Ser Asp Ser Tyr Ala Tyr Ser Ser Pro Ser Phe Gln 
1               5                   10                  15      


Gly 
    


<210> 454
<211> 51
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H2

<400> 454
agaattgatc cgagtgactc ctatgcctac tcgagcccgt ccttccaagg c                51


<210> 455
<211> 12
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H3

<400> 455
Ala Arg His Lys Glu Asn Tyr Asp Phe Trp Asp Phe 
1               5                   10          


<210> 456
<211> 36
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H3

<400> 456
gcgagacaca aagagaatta cgatttttgg gatttc                                 36


<210> 457
<211> 336
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region

<400> 457
gaaacgacac tcacgcagtc tccagactcc ctggctgtgt ccctgggcga gagggccacc       60

atcaactgca ggtccagcca gcctattttg ttcaacccca tcaataaact ctccttagct      120

tggtaccagc tcaaaccagg acagcctcct aagctgctca tttcctgggc atctacccgg      180

gaacccgggg tccctgaccg attcaatggc agcgggtctg ggacagtttt cactctcacc      240

atcagcagcc tgcagcctga agatgtggca gtttatgtct gtcagcaata ttttactagt      300

acttttttcg gccctgggac caaggtggaa atcaaa                                336


<210> 458
<211> 112
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region

<400> 458
Glu Thr Thr Leu Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Glu Arg Ala Thr Ile Asn Cys Arg Ser Ser Gln Pro Ile Leu Phe Asn 
            20                  25                  30          


Pro Ile Asn Lys Leu Ser Leu Ala Trp Tyr Gln Leu Lys Pro Gly Gln 
        35                  40                  45              


Pro Pro Lys Leu Leu Ile Ser Trp Ala Ser Thr Arg Glu Pro Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Asn Gly Ser Gly Ser Gly Thr Val Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Leu Gln Pro Glu Asp Val Ala Val Tyr Val Cys Gln Gln 
                85                  90                  95      


Tyr Phe Thr Ser Thr Phe Phe Gly Pro Gly Thr Lys Val Glu Ile Lys 
            100                 105                 110         


<210> 459
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region CDR L1

<400> 459
Arg Ser Ser Gln Pro Ile Leu Phe Asn Pro Ile Asn Lys Leu Ser Leu 
1               5                   10                  15      


Ala 
    


<210> 460
<211> 51
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region CDR L1

<400> 460
aggtccagcc agcctatttt gttcaacccc atcaataaac tctccttagc t                51


<210> 461
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region CDR L2

<400> 461
Trp Ala Ser Thr Arg Glu Pro 
1               5           


<210> 462
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region CDR L2

<400> 462
tgggcatcta cccgggaacc c                                                 21


<210> 463
<211> 8
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region CDR L3

<400> 463
Gln Gln Tyr Phe Thr Ser Thr Phe 
1               5               


<210> 464
<211> 24
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region CDR L3

<400> 464
cagcaatatt ttactagtac tttt                                              24


<210> 465
<211> 366
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region

<400> 465
gaggtgcagc tgttggagtc tggaagtgag gtgaagaagc ctgggacctc agtgaaggtc       60

tcctgcgaga cttctggtta catctttacc aactatgcta tctcctgggt gcgacaggcc      120

cctggacagg gtcttgagtg gctgggttgg atcagtggtt acaatggtca gacctactat      180

gcgcagaagg tccagggtag actcaccctg accacagaca cgtccacgat gacagcctac      240

atggacctga cgagccttag atctgacgac acggccattt attattgtgt gagagatgtc      300

cccgtgattt caggcgcttc cacaatggac tactggggcc agggaaccct ggtcaccgtc      360

tcctca                                                                 366


<210> 466
<211> 122
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region

<400> 466
Glu Val Gln Leu Leu Glu Ser Gly Ser Glu Val Lys Lys Pro Gly Thr 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Glu Thr Ser Gly Tyr Ile Phe Thr Asn Tyr 
            20                  25                  30          


Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Leu 
        35                  40                  45              


Gly Trp Ile Ser Gly Tyr Asn Gly Gln Thr Tyr Tyr Ala Gln Lys Val 
    50                  55                  60                  


Gln Gly Arg Leu Thr Leu Thr Thr Asp Thr Ser Thr Met Thr Ala Tyr 
65                  70                  75                  80  


Met Asp Leu Thr Ser Leu Arg Ser Asp Asp Thr Ala Ile Tyr Tyr Cys 
                85                  90                  95      


Val Arg Asp Val Pro Val Ile Ser Gly Ala Ser Thr Met Asp Tyr Trp 
            100                 105                 110         


Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120         


<210> 467
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H1

<400> 467
Tyr Ile Phe Thr Asn Tyr Ala Ile Ser 
1               5                   


<210> 468
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H1

<400> 468
tacatcttta ccaactatgc tatctcc                                           27


<210> 469
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H2

<400> 469
Trp Ile Ser Gly Tyr Asn Gly Gln Thr Tyr Tyr Ala Gln Lys Val Gln 
1               5                   10                  15      


Gly 
    


<210> 470
<211> 51
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H2

<400> 470
tggatcagtg gttacaatgg tcagacctac tatgcgcaga aggtccaggg t                51


<210> 471
<211> 15
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H3

<400> 471
Val Arg Asp Val Pro Val Ile Ser Gly Ala Ser Thr Met Asp Tyr 
1               5                   10                  15  


<210> 472
<211> 45
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H3

<400> 472
gtgagagatg tccccgtgat ttcaggcgct tccacaatgg actac                       45


<210> 473
<211> 336
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region

<400> 473
gatattgtga tgacgcagtc tccactctcc ctgcccgtca cccatggaca gccggcctcc       60

atctcctgca ggtctagtca aagcctcgtt tacagcgatg gaaacaccta cttgagttgg      120

tttcagctga ggccaggcca atctccaagg cgcctaattt ataaggtttc taaccgggac      180

tctggggtcc cagacagatt cagcggcagt gggtcaggca ctgatttcac actgaaaatc      240

agccgggtgg aggctgagga tgttggagtt tattactgca tgcaagctac acagtggcct      300

cgaacgttcg gccaagggac caaggtggag atcaaa                                336


<210> 474
<211> 112
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region

<400> 474
Asp Ile Val Met Thr Gln Ser Pro Leu Ser Leu Pro Val Thr His Gly 
1               5                   10                  15      


Gln Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Val Tyr Ser 
            20                  25                  30          


Asp Gly Asn Thr Tyr Leu Ser Trp Phe Gln Leu Arg Pro Gly Gln Ser 
        35                  40                  45              


Pro Arg Arg Leu Ile Tyr Lys Val Ser Asn Arg Asp Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Met Gln Ala 
                85                  90                  95      


Thr Gln Trp Pro Arg Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105                 110         


<210> 475
<211> 16
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region CDR L1

<400> 475
Arg Ser Ser Gln Ser Leu Val Tyr Ser Asp Gly Asn Thr Tyr Leu Ser 
1               5                   10                  15      


<210> 476
<211> 48
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region CDR L1

<400> 476
aggtctagtc aaagcctcgt ttacagcgat ggaaacacct acttgagt                    48


<210> 477
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region CDR L2

<400> 477
Lys Val Ser Asn Arg Asp Ser 
1               5           


<210> 478
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region CDR L2

<400> 478
aaggtttcta accgggactc t                                                 21


<210> 479
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region CDR L3

<400> 479
Met Gln Ala Thr Gln Trp Pro Arg Thr 
1               5                   


<210> 480
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region CDR L3

<400> 480
atgcaagcta cacagtggcc tcgaacg                                           27


<210> 481
<211> 378
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region

<400> 481
caggtccagc ttgtacagtc tggtcctacg ctggtgaggc ccacacagac cctcacgctg       60

acttgcacct tctctgggtt ctcactctct actcgtggcg tgggcgtggg ctgggtccgt      120

cagtccccag gaaaggcccc ggagttcctt gttctcgctc attgggatga tgataagatc      180

tacagtccat ctctcaggcg cagactctcc gtcaccaagg atgtctccaa aaaccaggtg      240

gtccttgcct tgaccaacgt ggaccctgtg gacacaggca catatttctg tgtcaagagc      300

gatctctatg atagaggtgg ctattactta tattactttg atcattgggg tcagggaacc      360

ctggtcaccg tctcctca                                                    378


<210> 482
<211> 126
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region

<400> 482
Gln Val Gln Leu Val Gln Ser Gly Pro Thr Leu Val Arg Pro Thr Gln 
1               5                   10                  15      


Thr Leu Thr Leu Thr Cys Thr Phe Ser Gly Phe Ser Leu Ser Thr Arg 
            20                  25                  30          


Gly Val Gly Val Gly Trp Val Arg Gln Ser Pro Gly Lys Ala Pro Glu 
        35                  40                  45              


Phe Leu Val Leu Ala His Trp Asp Asp Asp Lys Ile Tyr Ser Pro Ser 
    50                  55                  60                  


Leu Arg Arg Arg Leu Ser Val Thr Lys Asp Val Ser Lys Asn Gln Val 
65                  70                  75                  80  


Val Leu Ala Leu Thr Asn Val Asp Pro Val Asp Thr Gly Thr Tyr Phe 
                85                  90                  95      


Cys Val Lys Ser Asp Leu Tyr Asp Arg Gly Gly Tyr Tyr Leu Tyr Tyr 
            100                 105                 110         


Phe Asp His Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125     


<210> 483
<211> 11
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H1

<400> 483
Phe Ser Leu Ser Thr Arg Gly Val Gly Val Gly 
1               5                   10      


<210> 484
<211> 33
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H1

<400> 484
ttctcactct ctactcgtgg cgtgggcgtg ggc                                    33


<210> 485
<211> 16
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H2

<400> 485
Leu Ala His Trp Asp Asp Asp Lys Ile Tyr Ser Pro Ser Leu Arg Arg 
1               5                   10                  15      


<210> 486
<211> 48
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H2

<400> 486
ctcgctcatt gggatgatga taagatctac agtccatctc tcaggcgc                    48


<210> 487
<211> 18
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H3

<400> 487
Val Lys Ser Asp Leu Tyr Asp Arg Gly Gly Tyr Tyr Leu Tyr Tyr Phe 
1               5                   10                  15      


Asp His 
        


<210> 488
<211> 54
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H3

<400> 488
gtcaagagcg atctctatga tagaggtggc tattacttat attactttga tcat             54


<210> 489
<211> 321
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region

<400> 489
gacatccgga tgacccagtc tccatcctcc ctgtctgcat ctgtggggga cagagtcacc       60

atcacttgcc gggcaagtca gaccattgcc agttatgtga attggtatct gcaaagacca      120

ggggaagccc ctaaactcct gatctatgca gcttccaatt tgcacagtgg ggccccaccg      180

tcactcattg gcaggggctc tgggacagat ttcactctca ccatcaacac tctgcaacct      240

gaacattttg gaacttactt ctgtcagcag actttctcct ctccatacac ttttggccag      300

gggaccaagg tggaaatcaa a                                                321


<210> 490
<211> 107
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region

<400> 490
Asp Ile Arg Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Thr Ile Ala Ser Tyr 
            20                  25                  30          


Val Asn Trp Tyr Leu Gln Arg Pro Gly Glu Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Asn Leu His Ser Gly Ala Pro Pro Ser Leu Ile Gly 
    50                  55                  60                  


Arg Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Asn Thr Leu Gln Pro 
65                  70                  75                  80  


Glu His Phe Gly Thr Tyr Phe Cys Gln Gln Thr Phe Ser Ser Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210> 491
<211> 11
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region CDR L1

<400> 491
Arg Ala Ser Gln Thr Ile Ala Ser Tyr Val Asn 
1               5                   10      


<210> 492
<211> 33
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region CDR L1

<400> 492
cgggcaagtc agaccattgc cagttatgtg aat                                    33


<210> 493
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region CDR L2

<400> 493
Ala Ala Ser Asn Leu His Ser 
1               5           


<210> 494
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region CDR L2

<400> 494
gcagcttcca atttgcacag t                                                 21


<210> 495
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region CDR L3

<400> 495
Gln Gln Thr Phe Ser Ser Pro Tyr Thr 
1               5                   


<210> 496
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region CDR L3

<400> 496
cagcagactt tctcctctcc atacact                                           27


<210> 497
<211> 378
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region

<400> 497
caggtgcagc tggtggagtc tggtcctacg ctggtgaagc ccacacagac cctcacgctg       60

acctgcacct tctctgggtt ctcactcact actcgtggcg tgggtgtggg ctgggtccgt      120

cagcccccag gaaaggccct ggagttcctt ggactcactc attgggatga tgataagatc      180

tacagcccat ctctcaggcg cagactcacc atcaccaagg acacctccaa aaaccaggtg      240

gtccttgcat tggccaacgt ggaccctgtg gacacagcca catatttctg tgtaaaaagc      300

gatctctatg atagaggtgg ttattactta tactactttg actattgggg tcagggaacc      360

ctggtcaccg tctcctca                                                    378


<210> 498
<211> 126
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region

<400> 498
Gln Val Gln Leu Val Glu Ser Gly Pro Thr Leu Val Lys Pro Thr Gln 
1               5                   10                  15      


Thr Leu Thr Leu Thr Cys Thr Phe Ser Gly Phe Ser Leu Thr Thr Arg 
            20                  25                  30          


Gly Val Gly Val Gly Trp Val Arg Gln Pro Pro Gly Lys Ala Leu Glu 
        35                  40                  45              


Phe Leu Gly Leu Thr His Trp Asp Asp Asp Lys Ile Tyr Ser Pro Ser 
    50                  55                  60                  


Leu Arg Arg Arg Leu Thr Ile Thr Lys Asp Thr Ser Lys Asn Gln Val 
65                  70                  75                  80  


Val Leu Ala Leu Ala Asn Val Asp Pro Val Asp Thr Ala Thr Tyr Phe 
                85                  90                  95      


Cys Val Lys Ser Asp Leu Tyr Asp Arg Gly Gly Tyr Tyr Leu Tyr Tyr 
            100                 105                 110         


Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125     


<210> 499
<211> 11
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H1

<400> 499
Phe Ser Leu Thr Thr Arg Gly Val Gly Val Gly 
1               5                   10      


<210> 500
<211> 33
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H1

<400> 500
ttctcactca ctactcgtgg cgtgggtgtg ggc                                    33


<210> 501
<211> 16
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H2

<400> 501
Leu Thr His Trp Asp Asp Asp Lys Ile Tyr Ser Pro Ser Leu Arg Arg 
1               5                   10                  15      


<210> 502
<211> 48
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H2

<400> 502
ctcactcatt gggatgatga taagatctac agcccatctc tcaggcgc                    48


<210> 503
<211> 18
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H3

<400> 503
Val Lys Ser Asp Leu Tyr Asp Arg Gly Gly Tyr Tyr Leu Tyr Tyr Phe 
1               5                   10                  15      


Asp Tyr 
        


<210> 504
<211> 54
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H3

<400> 504
gtaaaaagcg atctctatga tagaggtggt tattacttat actactttga ctat             54


<210> 505
<211> 321
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region

<400> 505
gaaattgtgt tgacacagtc tccatcctcc ctgtctgcat ctgtggggga cagagtcacc       60

atcacttgcc gggcaagtca gaccattccc agttatgtaa attggtatct gcaaagacca      120

ggggaagccc ctaaactcct gatctatggt gcttccaatt tgcacactgg ggccccacca      180

acattcattg gcaggggatc tggggcagat ttcactctca ccatcaacac tctgcaacct      240

gaacattttg gaacctacta ctgtcaacag actttctcct ctccatacac ttttggccag      300

gggaccaagg tggaaatcaa a                                                321


<210> 506
<211> 107
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region

<400> 506
Glu Ile Val Leu Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Thr Ile Pro Ser Tyr 
            20                  25                  30          


Val Asn Trp Tyr Leu Gln Arg Pro Gly Glu Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Gly Ala Ser Asn Leu His Thr Gly Ala Pro Pro Thr Phe Ile Gly 
    50                  55                  60                  


Arg Gly Ser Gly Ala Asp Phe Thr Leu Thr Ile Asn Thr Leu Gln Pro 
65                  70                  75                  80  


Glu His Phe Gly Thr Tyr Tyr Cys Gln Gln Thr Phe Ser Ser Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210> 507
<211> 11
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region CDR L1

<400> 507
Arg Ala Ser Gln Thr Ile Pro Ser Tyr Val Asn 
1               5                   10      


<210> 508
<211> 33
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region CDR L1

<400> 508
cgggcaagtc agaccattcc cagttatgta aat                                    33


<210> 509
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region CDR L2

<400> 509
Gly Ala Ser Asn Leu His Thr 
1               5           


<210> 510
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region CDR L2

<400> 510
ggtgcttcca atttgcacac t                                                 21


<210> 511
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region CDR L3

<400> 511
Gln Gln Thr Phe Ser Ser Pro Tyr Thr 
1               5                   


<210> 512
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region CDR L3

<400> 512
caacagactt tctcctctcc atacact                                           27


<210> 513
<211> 378
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region

<400> 513
caggtcacct tgaaggagtc tggtcctgcg ctggtgaaac ccacagagac cctcacactg       60

acctgtacct tctctggctt ctcactcagc actaaaagac tgagtgtgag ttggatccgt      120

cagcccccag ggaaggccct ggagtggctt gctcgcatag attgggatga tgataaatct      180

tacagcacat ctctgaggac caggctcacc atcgccaagg acacttccaa aaaccaggtc      240

gtccttacaa tgaccaacat gggccccgcg gacacagcca cctatttctg tgttcggtct      300

tctgtatatg ctagtaatgc ttattacctc tactactttg actcttgggg ccagggaacc      360

ctggtcaccg tctcctca                                                    378


<210> 514
<211> 126
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region

<400> 514
Gln Val Thr Leu Lys Glu Ser Gly Pro Ala Leu Val Lys Pro Thr Glu 
1               5                   10                  15      


Thr Leu Thr Leu Thr Cys Thr Phe Ser Gly Phe Ser Leu Ser Thr Lys 
            20                  25                  30          


Arg Leu Ser Val Ser Trp Ile Arg Gln Pro Pro Gly Lys Ala Leu Glu 
        35                  40                  45              


Trp Leu Ala Arg Ile Asp Trp Asp Asp Asp Lys Ser Tyr Ser Thr Ser 
    50                  55                  60                  


Leu Arg Thr Arg Leu Thr Ile Ala Lys Asp Thr Ser Lys Asn Gln Val 
65                  70                  75                  80  


Val Leu Thr Met Thr Asn Met Gly Pro Ala Asp Thr Ala Thr Tyr Phe 
                85                  90                  95      


Cys Val Arg Ser Ser Val Tyr Ala Ser Asn Ala Tyr Tyr Leu Tyr Tyr 
            100                 105                 110         


Phe Asp Ser Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125     


<210> 515
<211> 11
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H1

<400> 515
Phe Ser Leu Ser Thr Lys Arg Leu Ser Val Ser 
1               5                   10      


<210> 516
<211> 33
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H1

<400> 516
ttctcactca gcactaaaag actgagtgtg agt                                    33


<210> 517
<211> 16
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H2

<400> 517
Arg Ile Asp Trp Asp Asp Asp Lys Ser Tyr Ser Thr Ser Leu Arg Thr 
1               5                   10                  15      


<210> 518
<211> 48
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H2

<400> 518
cgcatagatt gggatgatga taaatcttac agcacatctc tgaggacc                    48


<210> 519
<211> 18
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H3

<400> 519
Val Arg Ser Ser Val Tyr Ala Ser Asn Ala Tyr Tyr Leu Tyr Tyr Phe 
1               5                   10                  15      


Asp Ser 
        


<210> 520
<211> 54
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H3

<400> 520
gttcggtctt ctgtatatgc tagtaatgct tattacctct actactttga ctct             54


<210> 521
<211> 321
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region

<400> 521
gacatccgga tgacccagtc tccatcttcc ctgtctgcat ctgtcggaga cagagtcacc       60

atcacttgcc gggcaagtca gagcattgcc acctacttaa attggtatca gcacaaacca      120

gggaaagccc ctaccctcct gatctatgct gcatccattt tgcacagtgg tgtcccgcca      180

aggttcagtg gccgtgcctc tgggacagat ttcactctca ccatcagcag tctgcaacct      240

gaagattttg caacttacta ctgtcaacag gcctacagtt ccccttacac ttttggccag      300

gggaccaaag tggatatcaa a                                                321


<210> 522
<211> 107
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region

<400> 522
Asp Ile Arg Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ala Thr Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln His Lys Pro Gly Lys Ala Pro Thr Leu Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Ile Leu His Ser Gly Val Pro Pro Arg Phe Ser Gly 
    50                  55                  60                  


Arg Ala Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ala Tyr Ser Ser Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Asp Ile Lys 
            100                 105         


<210> 523
<211> 11
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region CDR L1

<400> 523
Arg Ala Ser Gln Ser Ile Ala Thr Tyr Leu Asn 
1               5                   10      


<210> 524
<211> 33
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region CDR L1

<400> 524
cgggcaagtc agagcattgc cacctactta aat                                    33


<210> 525
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region CDR L2

<400> 525
Ala Ala Ser Ile Leu His Ser 
1               5           


<210> 526
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region CDR L2

<400> 526
gctgcatcca ttttgcacag t                                                 21


<210> 527
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region CDR L3

<400> 527
Gln Gln Ala Tyr Ser Ser Pro Tyr Thr 
1               5                   


<210> 528
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region CDR L3

<400> 528
caacaggcct acagttcccc ttacact                                           27


<210> 529
<211> 378
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region

<400> 529
caggtccagc tggtgcagtc tggggctgag gtgaagaagc ctgggtcctc agtgaaggtc       60

tcctgcaagg cttctggagg caccttcggc agctatgctg tcatctgggt gcgacaggcc      120

cctggacaag ggcttgagtg gatgggacat atcatccctg tttttgggac aataaacaac      180

gcacagaagt tccagggcag actcaccctt agcgcagacg aatccacggg cacagtctac      240

atggggctga gcagcctgag atctgacgac acggccgtgt atttctgtgc gaccaagaga      300

tattgtagtg atcccagctg ccatggactc tggtacttcg atctctgggg ccgtggcacc      360

ctggtcaccg tctcctca                                                    378


<210> 530
<211> 126
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region

<400> 530
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Gly Ser Tyr 
            20                  25                  30          


Ala Val Ile Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly His Ile Ile Pro Val Phe Gly Thr Ile Asn Asn Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Leu Thr Leu Ser Ala Asp Glu Ser Thr Gly Thr Val Tyr 
65                  70                  75                  80  


Met Gly Leu Ser Ser Leu Arg Ser Asp Asp Thr Ala Val Tyr Phe Cys 
                85                  90                  95      


Ala Thr Lys Arg Tyr Cys Ser Asp Pro Ser Cys His Gly Leu Trp Tyr 
            100                 105                 110         


Phe Asp Leu Trp Gly Arg Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125     


<210> 531
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H1

<400> 531
Gly Thr Phe Gly Ser Tyr Ala Val Ile 
1               5                   


<210> 532
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H1

<400> 532
ggcaccttcg gcagctatgc tgtcatc                                           27


<210> 533
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H2

<400> 533
His Ile Ile Pro Val Phe Gly Thr Ile Asn Asn Ala Gln Lys Phe Gln 
1               5                   10                  15      


Gly 
    


<210> 534
<211> 51
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H2

<400> 534
catatcatcc ctgtttttgg gacaataaac aacgcacaga agttccaggg c                51


<210> 535
<211> 19
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H3

<400> 535
Ala Thr Lys Arg Tyr Cys Ser Asp Pro Ser Cys His Gly Leu Trp Tyr 
1               5                   10                  15      


Phe Asp Leu 
            


<210> 536
<211> 57
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H3

<400> 536
gcgaccaaga gatattgtag tgatcccagc tgccatggac tctggtactt cgatctc          57


<210> 537
<211> 339
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region

<400> 537
gacatccggt tgacccagtc tccactctcc ctgcccgtca cccctggaga gccggcctcc       60

atctcctgca ggtctagtca gagcctcttg gatagtgatg atggaaacac ctatttggac      120

tggtacctgc agaagccagg gcagtctcca caggtcctga tctatatgct ttcgtatcgg      180

gcctctggag tcccagacag gttcagtggc agtgggtcag gcactgattt cacactgaaa      240

atcagcaggg tggaggctga ggatgttgga gtttattact gcatgcaacg tgcagagttt      300

ccttacactt ttggccaggg gaccaagctg gagatcaaa                             339


<210> 538
<211> 113
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region

<400> 538
Asp Ile Arg Leu Thr Gln Ser Pro Leu Ser Leu Pro Val Thr Pro Gly 
1               5                   10                  15      


Glu Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Leu Asp Ser 
            20                  25                  30          


Asp Asp Gly Asn Thr Tyr Leu Asp Trp Tyr Leu Gln Lys Pro Gly Gln 
        35                  40                  45              


Ser Pro Gln Val Leu Ile Tyr Met Leu Ser Tyr Arg Ala Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys 
65                  70                  75                  80  


Ile Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Met Gln 
                85                  90                  95      


Arg Ala Glu Phe Pro Tyr Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile 
            100                 105                 110         


Lys 
    


<210> 539
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region CDR L1

<400> 539
Arg Ser Ser Gln Ser Leu Leu Asp Ser Asp Asp Gly Asn Thr Tyr Leu 
1               5                   10                  15      


Asp 
    


<210> 540
<211> 51
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region CDR L1

<400> 540
aggtctagtc agagcctctt ggatagtgat gatggaaaca cctatttgga c                51


<210> 541
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region CDR L2

<400> 541
Met Leu Ser Tyr Arg Ala Ser 
1               5           


<210> 542
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region CDR L2

<400> 542
atgctttcgt atcgggcctc t                                                 21


<210> 543
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region CDR L3

<400> 543
Met Gln Arg Ala Glu Phe Pro Tyr Thr 
1               5                   


<210> 544
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region CDR L3

<400> 544
atgcaacgtg cagagtttcc ttacact                                           27


<210> 545
<211> 357
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region

<400> 545
caggtccagc ttgtgcagtc tggagcagag gtgaaaaagc ccggggagcc tctgaggatc       60

tcctgtaagg gttctggata cacctttacc agctactgga tcagttgggt gcgccagatg      120

cccgggacag gccttgagtg gatggggaga attgatccga gtgactccta tacctactcg      180

agcccgtcct tccaaggcca cgtcaccatc tcagttgaca agtccatcag cactgcctac      240

ctgcaatgga gcagcctgaa ggcctcggac accgccatat attactgtgc gagacacaaa      300

gagaattacg atttttggga tttttggggc cagggaaccc tggtcaccgt ctcctca         357


<210> 546
<211> 119
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region

<400> 546
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu 
1               5                   10                  15      


Pro Leu Arg Ile Ser Cys Lys Gly Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Trp Ile Ser Trp Val Arg Gln Met Pro Gly Thr Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Arg Ile Asp Pro Ser Asp Ser Tyr Thr Tyr Ser Ser Pro Ser Phe 
    50                  55                  60                  


Gln Gly His Val Thr Ile Ser Val Asp Lys Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Trp Ser Ser Leu Lys Ala Ser Asp Thr Ala Ile Tyr Tyr Cys 
                85                  90                  95      


Ala Arg His Lys Glu Asn Tyr Asp Phe Trp Asp Phe Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210> 547
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H1

<400> 547
Tyr Thr Phe Thr Ser Tyr Trp Ile Ser 
1               5                   


<210> 548
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H1

<400> 548
tacaccttta ccagctactg gatcagt                                           27


<210> 549
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H2

<400> 549
Arg Ile Asp Pro Ser Asp Ser Tyr Thr Tyr Ser Ser Pro Ser Phe Gln 
1               5                   10                  15      


Gly 
    


<210> 550
<211> 51
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H2

<400> 550
agaattgatc cgagtgactc ctatacctac tcgagcccgt ccttccaagg c                51


<210> 551
<211> 12
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H3

<400> 551
Ala Arg His Lys Glu Asn Tyr Asp Phe Trp Asp Phe 
1               5                   10          


<210> 552
<211> 36
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H3

<400> 552
gcgagacaca aagagaatta cgatttttgg gatttt                                 36


<210> 553
<211> 336
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region

<400> 553
gaaacgacac tcacgcagtc tccagactcc ctggctgtgt ccctgggcga gagggccacc       60

atcaactgca agtccagcca gactattttc ttcaactcca ataataagat ctccttagct      120

tggtaccagc agaaaccagg acagcctcct aagctgctca tttcctgggc atctacccgc      180

gaatccgggg tccctgaccg attcagtggc agcgggtctg ggacagattt cactctcacc      240

atcagcagcc tgcagcctga ggatgtggca gtttatttct gtcagcaata ttatagtagt      300

gcttttttcg gccctgggac acgactggag attaaa                                336


<210> 554
<211> 112
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region

<400> 554
Glu Thr Thr Leu Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Glu Arg Ala Thr Ile Asn Cys Lys Ser Ser Gln Thr Ile Phe Phe Asn 
            20                  25                  30          


Ser Asn Asn Lys Ile Ser Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Pro Pro Lys Leu Leu Ile Ser Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Leu Gln Pro Glu Asp Val Ala Val Tyr Phe Cys Gln Gln 
                85                  90                  95      


Tyr Tyr Ser Ser Ala Phe Phe Gly Pro Gly Thr Arg Leu Glu Ile Lys 
            100                 105                 110         


<210> 555
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region CDR L1

<400> 555
Lys Ser Ser Gln Thr Ile Phe Phe Asn Ser Asn Asn Lys Ile Ser Leu 
1               5                   10                  15      


Ala 
    


<210> 556
<211> 51
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region CDR L1

<400> 556
aagtccagcc agactatttt cttcaactcc aataataaga tctccttagc t                51


<210> 557
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region CDR L2

<400> 557
Trp Ala Ser Thr Arg Glu Ser 
1               5           


<210> 558
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region CDR L2

<400> 558
tgggcatcta cccgcgaatc c                                                 21


<210> 559
<211> 8
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region CDR L3

<400> 559
Gln Gln Tyr Tyr Ser Ser Ala Phe 
1               5               


<210> 560
<211> 24
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region CDR L3

<400> 560
cagcaatatt atagtagtgc tttt                                              24


<210> 561
<211> 363
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region

<400> 561
caggtccagc tggtgcagtc tggacctgaa gtgaagaagc ctggggcctc agtgacgatc       60

tcctgtcagg cctctgggta catcttcaat cactactcta tcacctgggt gcgacaggcc      120

cctggacaag ggactgagtg gatggggtgg atcagcgcct atcacggtaa gacggaatat      180

tcagggaaat tccacggcag agtcaccctg accacagaca caggcacgcg gacagccttc      240

ttggaactta gggacctgac atctgacgac acggccattt attattgtgc gcgagatgtc      300

ccggtcatgg gagccgcatt tttggactac tggggccagg gaaccctggt caccgtctcc      360

tca                                                                    363


<210> 562
<211> 121
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region

<400> 562
Gln Val Gln Leu Val Gln Ser Gly Pro Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Thr Ile Ser Cys Gln Ala Ser Gly Tyr Ile Phe Asn His Tyr 
            20                  25                  30          


Ser Ile Thr Trp Val Arg Gln Ala Pro Gly Gln Gly Thr Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Ser Ala Tyr His Gly Lys Thr Glu Tyr Ser Gly Lys Phe 
    50                  55                  60                  


His Gly Arg Val Thr Leu Thr Thr Asp Thr Gly Thr Arg Thr Ala Phe 
65                  70                  75                  80  


Leu Glu Leu Arg Asp Leu Thr Ser Asp Asp Thr Ala Ile Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Val Pro Val Met Gly Ala Ala Phe Leu Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120     


<210> 563
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H1

<400> 563
Tyr Ile Phe Asn His Tyr Ser Ile Thr 
1               5                   


<210> 564
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H1

<400> 564
tacatcttca atcactactc tatcacc                                           27


<210> 565
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H2

<400> 565
Trp Ile Ser Ala Tyr His Gly Lys Thr Glu Tyr Ser Gly Lys Phe His 
1               5                   10                  15      


Gly 
    


<210> 566
<211> 51
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H2

<400> 566
tggatcagcg cctatcacgg taagacggaa tattcaggga aattccacgg c                51


<210> 567
<211> 14
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H3

<400> 567
Ala Arg Asp Val Pro Val Met Gly Ala Ala Phe Leu Asp Tyr 
1               5                   10                  


<210> 568
<211> 42
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H3

<400> 568
gcgcgagatg tcccggtcat gggagccgca tttttggact ac                          42


<210> 569
<211> 336
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region

<400> 569
gaaattgtgt tgacacagtc tccactctcc ctgcccgtca cccttggaca gccggcctcc       60

atctcctgca ggtctggtca aagtctcgaa ttcagtgatg gaaacaccta cttgacttgg      120

tttcagcaga ggccaggcca atctccaagg cgcctaattt ttaggggttc ttaccgggac      180

tctggggtcc ccgaaagatt cagcggcagt ggctcaggca cttctttcac actgacaatc      240

agcagggtgg aggctgagga tgttgggatt tatttctgca tgcaaggtac acactggcct      300

ccgacgttcg gccaagggac caagctggag atcaaa                                336


<210> 570
<211> 112
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region

<400> 570
Glu Ile Val Leu Thr Gln Ser Pro Leu Ser Leu Pro Val Thr Leu Gly 
1               5                   10                  15      


Gln Pro Ala Ser Ile Ser Cys Arg Ser Gly Gln Ser Leu Glu Phe Ser 
            20                  25                  30          


Asp Gly Asn Thr Tyr Leu Thr Trp Phe Gln Gln Arg Pro Gly Gln Ser 
        35                  40                  45              


Pro Arg Arg Leu Ile Phe Arg Gly Ser Tyr Arg Asp Ser Gly Val Pro 
    50                  55                  60                  


Glu Arg Phe Ser Gly Ser Gly Ser Gly Thr Ser Phe Thr Leu Thr Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Val Gly Ile Tyr Phe Cys Met Gln Gly 
                85                  90                  95      


Thr His Trp Pro Pro Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


<210> 571
<211> 16
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region CDR L1

<400> 571
Arg Ser Gly Gln Ser Leu Glu Phe Ser Asp Gly Asn Thr Tyr Leu Thr 
1               5                   10                  15      


<210> 572
<211> 48
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region CDR L1

<400> 572
aggtctggtc aaagtctcga attcagtgat ggaaacacct acttgact                    48


<210> 573
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region CDR L2

<400> 573
Arg Gly Ser Tyr Arg Asp Ser 
1               5           


<210> 574
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region CDR L2

<400> 574
aggggttctt accgggactc t                                                 21


<210> 575
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region CDR L3

<400> 575
Met Gln Gly Thr His Trp Pro Pro Thr 
1               5                   


<210> 576
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region CDR L3

<400> 576
atgcaaggta cacactggcc tccgacg                                           27


<210> 577
<211> 378
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region

<400> 577
caggtgcagc tggtgcagtc tggccctgcg ctggtgaaac ccacgcagac cctcacactg       60

acctgcacct tctctgggtt ctcactcacc actgcaagaa tgtgtgtgag ttggatccgt      120

cagcccccag ggaaggccct ggagtggctt gcacgcattg attgggatga tgataaatcc      180

tacagcacat ctctgaagac caggctcacc atcgccaagg acacatccaa aaaccaggtc      240

gtccttacca tgaccaacat gggccccgcg gacacagcca cttattactg tgtacggact      300

cctatatatg ctagtggtgg ttattacctc tcctactttg actcctgggg ccagggaacc      360

ctggtcaccg tctcctca                                                    378


<210> 578
<211> 126
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region

<400> 578
Gln Val Gln Leu Val Gln Ser Gly Pro Ala Leu Val Lys Pro Thr Gln 
1               5                   10                  15      


Thr Leu Thr Leu Thr Cys Thr Phe Ser Gly Phe Ser Leu Thr Thr Ala 
            20                  25                  30          


Arg Met Cys Val Ser Trp Ile Arg Gln Pro Pro Gly Lys Ala Leu Glu 
        35                  40                  45              


Trp Leu Ala Arg Ile Asp Trp Asp Asp Asp Lys Ser Tyr Ser Thr Ser 
    50                  55                  60                  


Leu Lys Thr Arg Leu Thr Ile Ala Lys Asp Thr Ser Lys Asn Gln Val 
65                  70                  75                  80  


Val Leu Thr Met Thr Asn Met Gly Pro Ala Asp Thr Ala Thr Tyr Tyr 
                85                  90                  95      


Cys Val Arg Thr Pro Ile Tyr Ala Ser Gly Gly Tyr Tyr Leu Ser Tyr 
            100                 105                 110         


Phe Asp Ser Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125     


<210> 579
<211> 11
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H1

<400> 579
Phe Ser Leu Thr Thr Ala Arg Met Cys Val Ser 
1               5                   10      


<210> 580
<211> 33
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H1

<400> 580
ttctcactca ccactgcaag aatgtgtgtg agt                                    33


<210> 581
<211> 16
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H2

<400> 581
Arg Ile Asp Trp Asp Asp Asp Lys Ser Tyr Ser Thr Ser Leu Lys Thr 
1               5                   10                  15      


<210> 582
<211> 48
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H2

<400> 582
cgcattgatt gggatgatga taaatcctac agcacatctc tgaagacc                    48


<210> 583
<211> 18
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H3

<400> 583
Val Arg Thr Pro Ile Tyr Ala Ser Gly Gly Tyr Tyr Leu Ser Tyr Phe 
1               5                   10                  15      


Asp Ser 
        


<210> 584
<211> 54
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H3

<400> 584
gtacggactc ctatatatgc tagtggtggt tattacctct cctactttga ctcc             54


<210> 585
<211> 321
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region

<400> 585
gatattgtga tgacgcagtc tccatcctcc ctgtctgcat ctgtcggaga cagcgtcacc       60

atcacttgcc gggcaagtca gactattgcc agctatgtga attggtatca gcacaaacca      120

gggcaagccc ctaacctcct gatctatgct gcatccattt tgcacagtgg ggtcccatca      180

aggttcagag gcggtggctc tgggacagat ttcactctca ccatcaacag tctgcaacct      240

gaagattttg caacttacta ctgtcaacag agttacagta ccccttacac ttttggccag      300

gggaccaaag tggatatcaa a                                                321


<210> 586
<211> 107
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region

<400> 586
Asp Ile Val Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Ser Val Thr Ile Thr Cys Arg Ala Ser Gln Thr Ile Ala Ser Tyr 
            20                  25                  30          


Val Asn Trp Tyr Gln His Lys Pro Gly Gln Ala Pro Asn Leu Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Ile Leu His Ser Gly Val Pro Ser Arg Phe Arg Gly 
    50                  55                  60                  


Gly Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Asn Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Tyr Ser Thr Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Asp Ile Lys 
            100                 105         


<210> 587
<211> 11
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region CDR L1

<400> 587
Arg Ala Ser Gln Thr Ile Ala Ser Tyr Val Asn 
1               5                   10      


<210> 588
<211> 33
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region CDR L1

<400> 588
cgggcaagtc agactattgc cagctatgtg aat                                    33


<210> 589
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region CDR L2

<400> 589
Ala Ala Ser Ile Leu His Ser 
1               5           


<210> 590
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region CDR L2

<400> 590
gctgcatcca ttttgcacag t                                                 21


<210> 591
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region CDR L3

<400> 591
Gln Gln Ser Tyr Ser Thr Pro Tyr Thr 
1               5                   


<210> 592
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region CDR L3

<400> 592
caacagagtt acagtacccc ttacact                                           27


<210> 593
<211> 378
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region

<400> 593
caggtgcagc tggtggagtc tggtcctacg ctggtgaaac ccacacagac cctctcgctg       60

acctgcacct tctctgggtt ctcactcacc actcgtggag tgggtgtggg ctggatccgt      120

cagcccccag gaaaggccct ggagtggctt ggattcactt attgggatgg tgatgaccgc      180

tacagcccat ctctgaggaa cagagtctcc atcgccaagg acacctccaa aaaccaggtg      240

gtccttacac tgaccaacat ggaccctgtg gacacagcca cgtatttttg tgtacacagc      300

gatcgctatg acaggggtgg ttattactta tacttctttg actactgggg cccgggaacc      360

ctggtcaccg tctcctca                                                    378


<210> 594
<211> 126
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region

<400> 594
Gln Val Gln Leu Val Glu Ser Gly Pro Thr Leu Val Lys Pro Thr Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Phe Ser Gly Phe Ser Leu Thr Thr Arg 
            20                  25                  30          


Gly Val Gly Val Gly Trp Ile Arg Gln Pro Pro Gly Lys Ala Leu Glu 
        35                  40                  45              


Trp Leu Gly Phe Thr Tyr Trp Asp Gly Asp Asp Arg Tyr Ser Pro Ser 
    50                  55                  60                  


Leu Arg Asn Arg Val Ser Ile Ala Lys Asp Thr Ser Lys Asn Gln Val 
65                  70                  75                  80  


Val Leu Thr Leu Thr Asn Met Asp Pro Val Asp Thr Ala Thr Tyr Phe 
                85                  90                  95      


Cys Val His Ser Asp Arg Tyr Asp Arg Gly Gly Tyr Tyr Leu Tyr Phe 
            100                 105                 110         


Phe Asp Tyr Trp Gly Pro Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125     


<210> 595
<211> 11
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H1

<400> 595
Phe Ser Leu Thr Thr Arg Gly Val Gly Val Gly 
1               5                   10      


<210> 596
<211> 33
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H1

<400> 596
ttctcactca ccactcgtgg agtgggtgtg ggc                                    33


<210> 597
<211> 16
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H2

<400> 597
Phe Thr Tyr Trp Asp Gly Asp Asp Arg Tyr Ser Pro Ser Leu Arg Asn 
1               5                   10                  15      


<210> 598
<211> 48
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H2

<400> 598
ttcacttatt gggatggtga tgaccgctac agcccatctc tgaggaac                    48


<210> 599
<211> 18
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H3

<400> 599
Val His Ser Asp Arg Tyr Asp Arg Gly Gly Tyr Tyr Leu Tyr Phe Phe 
1               5                   10                  15      


Asp Tyr 
        


<210> 600
<211> 54
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H3

<400> 600
gtacacagcg atcgctatga caggggtggt tattacttat acttctttga ctac             54


<210> 601
<211> 321
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region

<400> 601
gacatccgag tcacccagtc tccatcctcc ctgtctgcgt ctgtggggga cagagtctcc       60

atcagttgcc gggcaagtca gaccattgcc agttatgtaa attggtatca gcagagacca      120

gggaaagccc ctcaactcct gatctttgct gcatcccatt tgcagactgg ggtcccatca      180

agattcagtg gcaggggctc tgggacagat ttcactctca ccatcacctc tctgcaacct      240

gaagattttg caacttacta ctgtcaacag agttacactt ccccgtacac ttttggccag      300

gggaccaagg tggaaatcaa a                                                321


<210> 602
<211> 107
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region

<400> 602
Asp Ile Arg Val Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Ser Ile Ser Cys Arg Ala Ser Gln Thr Ile Ala Ser Tyr 
            20                  25                  30          


Val Asn Trp Tyr Gln Gln Arg Pro Gly Lys Ala Pro Gln Leu Leu Ile 
        35                  40                  45              


Phe Ala Ala Ser His Leu Gln Thr Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Arg Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Thr Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Tyr Thr Ser Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210> 603
<211> 11
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region CDR L1

<400> 603
Arg Ala Ser Gln Thr Ile Ala Ser Tyr Val Asn 
1               5                   10      


<210> 604
<211> 33
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region CDR L1

<400> 604
cgggcaagtc agaccattgc cagttatgta aat                                    33


<210> 605
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region CDR L2

<400> 605
Ala Ala Ser His Leu Gln Thr 
1               5           


<210> 606
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region CDR L2

<400> 606
gctgcatccc atttgcagac t                                                 21


<210> 607
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region CDR L3

<400> 607
Gln Gln Ser Tyr Thr Ser Pro Tyr Thr 
1               5                   


<210> 608
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region CDR L3

<400> 608
caacagagtt acacttcccc gtacact                                           27


<210> 609
<211> 378
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region

<400> 609
gaggtgcagc tggtggagtc tggtcctacg ctggtgaaac ccacacagac cctcacgctg       60

acctgctccc tctctgggtt ctcactcacc actcgtgggg tgggtgtggg ctggatccgc      120

cagcccccag gaaaggcccc ggagtgcctt ggattcgttt attgggatga tgataaccgc      180

tacagcccat ctctgagggg cagactcacc atctccaagg acacgtccaa gaaccaggtg      240

gtccttacac tgaccaacat ggaccctttg gacacagcca cctattactg tgttcacagc      300

gatctctatg atagaggtgg ttattactta ttctactttg acgactgggg ccagggaacc      360

ctggtcaccg tctcctca                                                    378


<210> 610
<211> 126
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region

<400> 610
Glu Val Gln Leu Val Glu Ser Gly Pro Thr Leu Val Lys Pro Thr Gln 
1               5                   10                  15      


Thr Leu Thr Leu Thr Cys Ser Leu Ser Gly Phe Ser Leu Thr Thr Arg 
            20                  25                  30          


Gly Val Gly Val Gly Trp Ile Arg Gln Pro Pro Gly Lys Ala Pro Glu 
        35                  40                  45              


Cys Leu Gly Phe Val Tyr Trp Asp Asp Asp Asn Arg Tyr Ser Pro Ser 
    50                  55                  60                  


Leu Arg Gly Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Val 
65                  70                  75                  80  


Val Leu Thr Leu Thr Asn Met Asp Pro Leu Asp Thr Ala Thr Tyr Tyr 
                85                  90                  95      


Cys Val His Ser Asp Leu Tyr Asp Arg Gly Gly Tyr Tyr Leu Phe Tyr 
            100                 105                 110         


Phe Asp Asp Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125     


<210> 611
<211> 11
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H1

<400> 611
Phe Ser Leu Thr Thr Arg Gly Val Gly Val Gly 
1               5                   10      


<210> 612
<211> 33
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H1

<400> 612
ttctcactca ccactcgtgg ggtgggtgtg ggc                                    33


<210> 613
<211> 16
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H2

<400> 613
Phe Val Tyr Trp Asp Asp Asp Asn Arg Tyr Ser Pro Ser Leu Arg Gly 
1               5                   10                  15      


<210> 614
<211> 48
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H2

<400> 614
ttcgtttatt gggatgatga taaccgctac agcccatctc tgaggggc                    48


<210> 615
<211> 18
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H3

<400> 615
Val His Ser Asp Leu Tyr Asp Arg Gly Gly Tyr Tyr Leu Phe Tyr Phe 
1               5                   10                  15      


Asp Asp 
        


<210> 616
<211> 54
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H3

<400> 616
gttcacagcg atctctatga tagaggtggt tattacttat tctactttga cgac             54


<210> 617
<211> 321
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region

<400> 617
gacatccagg tgacccagtc tccatcctcc ctgtctgcat ctgtggggga cagagtcacc       60

atcacttgcc gggcaagtca gcccattgcc agttatttaa attggtatca gcagaaacca      120

gggcaagccc ctaaactcct catctatgct gcatccatgt tgcagagtgg ggccccatca      180

aaattcagtg gccggggatc tgggacagat ttcactctca ccatcaccac tctacaacct      240

gaagattttg caacttacta ctgtcaacag agttacactt tcccgtacac ttttggccag      300

gggaccaagg tggaaatcaa a                                                321


<210> 618
<211> 107
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region

<400> 618
Asp Ile Gln Val Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Pro Ile Ala Ser Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Met Leu Gln Ser Gly Ala Pro Ser Lys Phe Ser Gly 
    50                  55                  60                  


Arg Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Thr Thr Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Tyr Thr Phe Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210> 619
<211> 11
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region CDR L1

<400> 619
Arg Ala Ser Gln Pro Ile Ala Ser Tyr Leu Asn 
1               5                   10      


<210> 620
<211> 33
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region CDR L1

<400> 620
cgggcaagtc agcccattgc cagttattta aat                                    33


<210> 621
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region CDR L2

<400> 621
Ala Ala Ser Met Leu Gln Ser 
1               5           


<210> 622
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region CDR L2

<400> 622
gctgcatcca tgttgcagag t                                                 21


<210> 623
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region CDR L3

<400> 623
Gln Gln Ser Tyr Thr Phe Pro Tyr Thr 
1               5                   


<210> 624
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region CDR L3

<400> 624
caacagagtt acactttccc gtacact                                           27


<210> 625
<211> 369
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region

<400> 625
gaggtgcagc tggtggagtc tgggggaggc ttggtcaagc ctggagggtc cctgagactc       60

tcctgtgcag cctctggatt caccttcagt gactactaca tgagctggat ccgccaggct      120

ccagggaagg gactggagtg ggtttcatat attagtatta gtagtagtta cacagactac      180

gcagactctg tgaagggccg attcaccatc tccagagaca acgccaagaa ctcactgtat      240

ctgcaaatga acagcctgag agccgaggac acggccgtgt attactgtgc gagagatcaa      300

cgagaccaag cagtggctgg tcggtggttc gacccctggg gccagggaac cctggtcacc      360

gtctcctca                                                              369


<210> 626
<211> 123
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region

<400> 626
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp Tyr 
            20                  25                  30          


Tyr Met Ser Trp Ile Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Tyr Ile Ser Ile Ser Ser Ser Tyr Thr Asp Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Gln Arg Asp Gln Ala Val Ala Gly Arg Trp Phe Asp Pro 
            100                 105                 110         


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120             


<210> 627
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H1

<400> 627
Phe Thr Phe Ser Asp Tyr Tyr Met Ser 
1               5                   


<210> 628
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H1

<400> 628
ttcaccttca gtgactacta catgagc                                           27


<210> 629
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H2

<400> 629
Tyr Ile Ser Ile Ser Ser Ser Tyr Thr Asp Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210> 630
<211> 51
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H2

<400> 630
tatattagta ttagtagtag ttacacagac tacgcagact ctgtgaaggg c                51


<210> 631
<211> 16
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H3

<400> 631
Ala Arg Asp Gln Arg Asp Gln Ala Val Ala Gly Arg Trp Phe Asp Pro 
1               5                   10                  15      


<210> 632
<211> 48
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H3

<400> 632
gcgagagatc aacgagacca agcagtggct ggtcggtggt tcgacccc                    48


<210> 633
<211> 336
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region

<400> 633
cagtctgtgg tgacgcagcc gccctcagtg tctggggccc cagggcagag ggtcaccatc       60

tcctgcactg ggagcagctc caacatcggg gcaggttttg atgtacactg gtaccagcag      120

gttccaggaa cagcccccaa actcctcatc tatgctaaca ccaatcggcc ctcaggggtc      180

ccagaccgat tctctggctc caagtctggc acctcagcct ccctggccat cactgggctc      240

aaggctgagg atgaggctga ttattactgc cagtcctatg acaacagcct gagtggttcg      300

gcggtcttcg gcggagggac caaggtcacc gtccta                                336


<210> 634
<211> 112
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region

<400> 634
Gln Ser Val Val Thr Gln Pro Pro Ser Val Ser Gly Ala Pro Gly Gln 
1               5                   10                  15      


Arg Val Thr Ile Ser Cys Thr Gly Ser Ser Ser Asn Ile Gly Ala Gly 
            20                  25                  30          


Phe Asp Val His Trp Tyr Gln Gln Val Pro Gly Thr Ala Pro Lys Leu 
        35                  40                  45              


Leu Ile Tyr Ala Asn Thr Asn Arg Pro Ser Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Thr Gly Leu 
65                  70                  75                  80  


Lys Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Gln Ser Tyr Asp Asn Ser 
                85                  90                  95      


Leu Ser Gly Ser Ala Val Phe Gly Gly Gly Thr Lys Val Thr Val Leu 
            100                 105                 110         


<210> 635
<211> 14
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region CDR L1

<400> 635
Thr Gly Ser Ser Ser Asn Ile Gly Ala Gly Phe Asp Val His 
1               5                   10                  


<210> 636
<211> 42
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region CDR L1

<400> 636
actgggagca gctccaacat cggggcaggt tttgatgtac ac                          42


<210> 637
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region CDR L2

<400> 637
Ala Asn Thr Asn Arg Pro Ser 
1               5           


<210> 638
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region CDR L2

<400> 638
gctaacacca atcggccctc a                                                 21


<210> 639
<211> 12
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region CDR L3

<400> 639
Gln Ser Tyr Asp Asn Ser Leu Ser Gly Ser Ala Val 
1               5                   10          


<210> 640
<211> 36
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region CDR L3

<400> 640
cagtcctatg acaacagcct gagtggttcg gcggtc                                 36


<210> 641
<211> 366
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region

<400> 641
caggtgcagc tggtgcaatc tggttctgag gtgaagcagc ctggggcctc agtgaaggtc       60

tcctgcaagg cctctggata caccttcagc gcctaccatc tgcactgggt gcgccaggcc      120

cccggacaag ggcttcagtg gctgggcagg atcaacccta acagtggtgc cacaagcgtt      180

gcacataact ttcagggcag ggtcaccttg accacggaca cgtccatcag cacagcctac      240

atggagctga gcagcctgac gtctgacgac agtgccgtgt attactgcgc gagaactatg      300

tggcggtggc tggtcgaggg gggctttgag aactggggcc agggaaccct ggtcaccgtc      360

tcctca                                                                 366


<210> 642
<211> 122
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region

<400> 642
Gln Val Gln Leu Val Gln Ser Gly Ser Glu Val Lys Gln Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Ser Ala Tyr 
            20                  25                  30          


His Leu His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Gln Trp Leu 
        35                  40                  45              


Gly Arg Ile Asn Pro Asn Ser Gly Ala Thr Ser Val Ala His Asn Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Leu Thr Thr Asp Thr Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Thr Ser Asp Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Thr Met Trp Arg Trp Leu Val Glu Gly Gly Phe Glu Asn Trp 
            100                 105                 110         


Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120         


<210> 643
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H1

<400> 643
Tyr Thr Phe Ser Ala Tyr His Leu His 
1               5                   


<210> 644
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H1

<400> 644
tacaccttca gcgcctacca tctgcac                                           27


<210> 645
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H2

<400> 645
Arg Ile Asn Pro Asn Ser Gly Ala Thr Ser Val Ala His Asn Phe Gln 
1               5                   10                  15      


Gly 
    


<210> 646
<211> 51
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H2

<400> 646
aggatcaacc ctaacagtgg tgccacaagc gttgcacata actttcaggg c                51


<210> 647
<211> 15
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H3

<400> 647
Ala Arg Thr Met Trp Arg Trp Leu Val Glu Gly Gly Phe Glu Asn 
1               5                   10                  15  


<210> 648
<211> 45
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H3

<400> 648
gcgagaacta tgtggcggtg gctggtcgag gggggctttg agaac                       45


<210> 649
<211> 336
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region

<400> 649
gacatccgga tgacccagtc tccactctcc ctgcccgtca cccctggaga gccggcctcc       60

atctcctgca ggtctagtca gagcctcctg catagtaatg gagacaacta tttggattgg      120

tacctgcaga agccagggca gtctccacag gtcctgatct atctgggttc taatcgggcc      180

tccggggtcc ctgacaggtt cagtggcagt ggatcaggca cagattttac actgaaaatc      240

agcagagtgg aggctgagga tgttggggtt tattactgca tgcaagctct acaaactccg      300

ctcactttcg gcggagggac caaggtggaa atcaaa                                336


<210> 650
<211> 112
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region

<400> 650
Asp Ile Arg Met Thr Gln Ser Pro Leu Ser Leu Pro Val Thr Pro Gly 
1               5                   10                  15      


Glu Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Leu His Ser 
            20                  25                  30          


Asn Gly Asp Asn Tyr Leu Asp Trp Tyr Leu Gln Lys Pro Gly Gln Ser 
        35                  40                  45              


Pro Gln Val Leu Ile Tyr Leu Gly Ser Asn Arg Ala Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Met Gln Ala 
                85                  90                  95      


Leu Gln Thr Pro Leu Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105                 110         


<210> 651
<211> 16
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region CDR L1

<400> 651
Arg Ser Ser Gln Ser Leu Leu His Ser Asn Gly Asp Asn Tyr Leu Asp 
1               5                   10                  15      


<210> 652
<211> 48
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region CDR L1

<400> 652
aggtctagtc agagcctcct gcatagtaat ggagacaact atttggat                    48


<210> 653
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region CDR L2

<400> 653
Leu Gly Ser Asn Arg Ala Ser 
1               5           


<210> 654
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region CDR L2

<400> 654
ctgggttcta atcgggcctc c                                                 21


<210> 655
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region CDR L3

<400> 655
Met Gln Ala Leu Gln Thr Pro Leu Thr 
1               5                   


<210> 656
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region CDR L3

<400> 656
atgcaagctc tacaaactcc gctcact                                           27


<210> 657
<211> 363
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region

<400> 657
caggtccagc tggtgcagtc tggggctgag gtgaagaagc cggggtcctc gatgagcatc       60

tcctgtcggg cttctggagg ctccttcaac aaccaagcta tacactggat ccgccaggcc      120

cctggagaag gacttgagtg gatgggaaat atcatcccta atttcggatc tcaaaactac      180

gcgccggaat tcgtgggcag ggtcagcttc aatgcggacg cttccgctgg cactgcctac      240

atggacttga gtgatctgac atctcaagac acggccgtct attactgtgc gacagccggg      300

tggttcgggg aattggtgcg ctttgactcc tggggccagg gaaccctggt caccgtctcc      360

tca                                                                    363


<210> 658
<211> 121
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region

<400> 658
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Met Ser Ile Ser Cys Arg Ala Ser Gly Gly Ser Phe Asn Asn Gln 
            20                  25                  30          


Ala Ile His Trp Ile Arg Gln Ala Pro Gly Glu Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Asn Ile Ile Pro Asn Phe Gly Ser Gln Asn Tyr Ala Pro Glu Phe 
    50                  55                  60                  


Val Gly Arg Val Ser Phe Asn Ala Asp Ala Ser Ala Gly Thr Ala Tyr 
65                  70                  75                  80  


Met Asp Leu Ser Asp Leu Thr Ser Gln Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Thr Ala Gly Trp Phe Gly Glu Leu Val Arg Phe Asp Ser Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120     


<210> 659
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H1

<400> 659
Gly Ser Phe Asn Asn Gln Ala Ile His 
1               5                   


<210> 660
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H1

<400> 660
ggctccttca acaaccaagc tatacac                                           27


<210> 661
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H2

<400> 661
Asn Ile Ile Pro Asn Phe Gly Ser Gln Asn Tyr Ala Pro Glu Phe Val 
1               5                   10                  15      


Gly 
    


<210> 662
<211> 51
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H2

<400> 662
aatatcatcc ctaatttcgg atctcaaaac tacgcgccgg aattcgtggg c                51


<210> 663
<211> 14
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H3

<400> 663
Ala Thr Ala Gly Trp Phe Gly Glu Leu Val Arg Phe Asp Ser 
1               5                   10                  


<210> 664
<211> 42
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H3

<400> 664
gcgacagccg ggtggttcgg ggaattggtg cgctttgact cc                          42


<210> 665
<211> 324
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region

<400> 665
gatattgtga tgacgcagtc tccagccacc ctgtctgtgt ctccaggggg aagggccacc       60

ctctcctgca gggccagtga gactattacc actaacttag cctggtacca gcagaagcct      120

ggccaggctc ccaggctcct catctatggt gcgtccacca gggccactgg tatcccagcc      180

aggttcagtg gcagtgggtc agggacagag ttcactctca ccatcaacag cctgcagtct      240

gaggattttg cagtttatta ctgtcagcag tataataact ggcctcctct cactttcggc      300

ggagggacca agctggagat caaa                                             324


<210> 666
<211> 108
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region

<400> 666
Asp Ile Val Met Thr Gln Ser Pro Ala Thr Leu Ser Val Ser Pro Gly 
1               5                   10                  15      


Gly Arg Ala Thr Leu Ser Cys Arg Ala Ser Glu Thr Ile Thr Thr Asn 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 
        35                  40                  45              


Tyr Gly Ala Ser Thr Arg Ala Thr Gly Ile Pro Ala Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Asn Ser Leu Gln Ser 
65                  70                  75                  80  


Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Asn Asn Trp Pro Pro 
                85                  90                  95      


Leu Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105             


<210> 667
<211> 11
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region CDR L1

<400> 667
Arg Ala Ser Glu Thr Ile Thr Thr Asn Leu Ala 
1               5                   10      


<210> 668
<211> 33
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region CDR L1

<400> 668
agggccagtg agactattac cactaactta gcc                                    33


<210> 669
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region CDR L2

<400> 669
Gly Ala Ser Thr Arg Ala Thr 
1               5           


<210> 670
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region CDR L2

<400> 670
ggtgcgtcca ccagggccac t                                                 21


<210> 671
<211> 10
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region CDR L3

<400> 671
Gln Gln Tyr Asn Asn Trp Pro Pro Leu Thr 
1               5                   10  


<210> 672
<211> 30
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region CDR L3

<400> 672
cagcagtata ataactggcc tcctctcact                                        30


<210> 673
<211> 366
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region

<400> 673
caggtgcagc tacagcagtg gggcgcagga ctggtgaagc cttcggagac cctgtccctc       60

acctgcgctg tgtctggtgg gtccttcagg ggttaccagt ggaactggtt ccgccagccc      120

cccgggaagg gtctggagtg gattggggaa atcaatcatg gtgaatacac ccactacaac      180

gcgtccctca agagtcgcgt cagtttatct atagacacgt ccaagaacca gttctccctt      240

aatctgacct ctgtgaccgc cgcggacacg gctatgtatt tttgtgcgag agcctcgagt      300

gggacctata acttcgagta ctggttcgac ccctggggcc agggaaccct ggtcaccgtc      360

tcctca                                                                 366


<210> 674
<211> 122
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region

<400> 674
Gln Val Gln Leu Gln Gln Trp Gly Ala Gly Leu Val Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Ala Val Ser Gly Gly Ser Phe Arg Gly Tyr 
            20                  25                  30          


Gln Trp Asn Trp Phe Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Glu Ile Asn His Gly Glu Tyr Thr His Tyr Asn Ala Ser Leu Lys 
    50                  55                  60                  


Ser Arg Val Ser Leu Ser Ile Asp Thr Ser Lys Asn Gln Phe Ser Leu 
65                  70                  75                  80  


Asn Leu Thr Ser Val Thr Ala Ala Asp Thr Ala Met Tyr Phe Cys Ala 
                85                  90                  95      


Arg Ala Ser Ser Gly Thr Tyr Asn Phe Glu Tyr Trp Phe Asp Pro Trp 
            100                 105                 110         


Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120         


<210> 675
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H1

<400> 675
Gly Ser Phe Arg Gly Tyr Gln Trp Asn 
1               5                   


<210> 676
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H1

<400> 676
gggtccttca ggggttacca gtggaac                                           27


<210> 677
<211> 16
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H2

<400> 677
Glu Ile Asn His Gly Glu Tyr Thr His Tyr Asn Ala Ser Leu Lys Ser 
1               5                   10                  15      


<210> 678
<211> 48
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H2

<400> 678
gaaatcaatc atggtgaata cacccactac aacgcgtccc tcaagagt                    48


<210> 679
<211> 16
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H3

<400> 679
Ala Arg Ala Ser Ser Gly Thr Tyr Asn Phe Glu Tyr Trp Phe Asp Pro 
1               5                   10                  15      


<210> 680
<211> 48
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H3

<400> 680
gcgagagcct cgagtgggac ctataacttc gagtactggt tcgacccc                    48


<210> 681
<211> 324
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region

<400> 681
tcctatgtgc tgacacagcc accctcggtg tcagtggccc caggaaagac ggcctggctt       60

acctgtgggg gaaacaacat tggaaataaa agagtgcact ggtaccagca gaagccaggc      120

caggcccctg tgctggtcgt gtatgatgat tacggccggc cctcagggac ctctgagcga      180

gtctctggct ccaactctgg gaacacggcc accctgacca tcagcagggt cgaagccggg      240

gatgaggccg agtattattg tcaggtgtgg gatgatccca gtgatcatgc ggtgttcggc      300

ggaggcaccc agctgaccgt cctc                                             324


<210> 682
<211> 108
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region

<400> 682
Ser Tyr Val Leu Thr Gln Pro Pro Ser Val Ser Val Ala Pro Gly Lys 
1               5                   10                  15      


Thr Ala Trp Leu Thr Cys Gly Gly Asn Asn Ile Gly Asn Lys Arg Val 
            20                  25                  30          


His Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Val Leu Val Val Tyr 
        35                  40                  45              


Asp Asp Tyr Gly Arg Pro Ser Gly Thr Ser Glu Arg Val Ser Gly Ser 
    50                  55                  60                  


Asn Ser Gly Asn Thr Ala Thr Leu Thr Ile Ser Arg Val Glu Ala Gly 
65                  70                  75                  80  


Asp Glu Ala Glu Tyr Tyr Cys Gln Val Trp Asp Asp Pro Ser Asp His 
                85                  90                  95      


Ala Val Phe Gly Gly Gly Thr Gln Leu Thr Val Leu 
            100                 105             


<210> 683
<211> 11
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region CDR L1

<400> 683
Gly Gly Asn Asn Ile Gly Asn Lys Arg Val His 
1               5                   10      


<210> 684
<211> 33
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region CDR L1

<400> 684
gggggaaaca acattggaaa taaaagagtg cac                                    33


<210> 685
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region CDR L2

<400> 685
Asp Asp Tyr Gly Arg Pro Ser 
1               5           


<210> 686
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region CDR L2

<400> 686
gatgattacg gccggccctc a                                                 21


<210> 687
<211> 11
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region CDR L3

<400> 687
Gln Val Trp Asp Asp Pro Ser Asp His Ala Val 
1               5                   10      


<210> 688
<211> 33
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region CDR L3

<400> 688
caggtgtggg atgatcccag tgatcatgcg gtg                                    33


<210> 689
<211> 363
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region

<400> 689
caggtccagc tggtgcagtc tgggggacga ctggtcaagc ctggggggtc cctgagactc       60

tcctgtggaa tgtctggatt cggcttcagt agttatagaa tgaattgggt ccgccaggct      120

ccagggaagg gactggagtg gatctcatcg attagtgcta gtagtagtta tacagactac      180

gcgaattcag tgaagggccg attcaccatc tccagagacg gcgccaattt gtttctgcaa      240

atgaacagcc tgagagtcga ggacacggct gtgtattatt gtgcgagaga ttggggggga      300

cattccattt ttggagcggt ccaagacctc tggggccagg gaaccctggt caccgtctcc      360

tca                                                                    363


<210> 690
<211> 121
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region

<400> 690
Gln Val Gln Leu Val Gln Ser Gly Gly Arg Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Gly Met Ser Gly Phe Gly Phe Ser Ser Tyr 
            20                  25                  30          


Arg Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Ser Ser Ile Ser Ala Ser Ser Ser Tyr Thr Asp Tyr Ala Asn Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Gly Ala Asn Leu Phe Leu Gln 
65                  70                  75                  80  


Met Asn Ser Leu Arg Val Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
                85                  90                  95      


Asp Trp Gly Gly His Ser Ile Phe Gly Ala Val Gln Asp Leu Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120     


<210> 691
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H1

<400> 691
Phe Gly Phe Ser Ser Tyr Arg Met Asn 
1               5                   


<210> 692
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H1

<400> 692
ttcggcttca gtagttatag aatgaat                                           27


<210> 693
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H2

<400> 693
Ser Ile Ser Ala Ser Ser Ser Tyr Thr Asp Tyr Ala Asn Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210> 694
<211> 51
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H2

<400> 694
tcgattagtg ctagtagtag ttatacagac tacgcgaatt cagtgaaggg c                51


<210> 695
<211> 16
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H3

<400> 695
Ala Arg Asp Trp Gly Gly His Ser Ile Phe Gly Ala Val Gln Asp Leu 
1               5                   10                  15      


<210> 696
<211> 48
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H3

<400> 696
gcgagagatt gggggggaca ttccattttt ggagcggtcc aagacctc                    48


<210> 697
<211> 330
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region

<400> 697
cagtctgtgc tgacgcagcc gccctcagtg tctggggccc ctgggcagag ggtcaccatc       60

tcctgctctg ggagcagttc caacatcggg gcaggttatg atgtccactg gtaccagcag      120

cttccaggaa cagcccccaa actcctcatc tatggtaaca ccaatcggcc ctcaggggtc      180

cctgaccgat tctctggctc caagtctggc acgtcagcct ccctggccat cactggcctc      240

caggccgagg atgaggctga ttattactgc cagtcctatg acagaagcct gagtcaggtc      300

ttcggagctg ggaccaaggt gaccgtccta                                       330


<210> 698
<211> 110
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region

<400> 698
Gln Ser Val Leu Thr Gln Pro Pro Ser Val Ser Gly Ala Pro Gly Gln 
1               5                   10                  15      


Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Ala Gly 
            20                  25                  30          


Tyr Asp Val His Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu 
        35                  40                  45              


Leu Ile Tyr Gly Asn Thr Asn Arg Pro Ser Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Thr Gly Leu 
65                  70                  75                  80  


Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Gln Ser Tyr Asp Arg Ser 
                85                  90                  95      


Leu Ser Gln Val Phe Gly Ala Gly Thr Lys Val Thr Val Leu 
            100                 105                 110 


<210> 699
<211> 14
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region CDR L1

<400> 699
Ser Gly Ser Ser Ser Asn Ile Gly Ala Gly Tyr Asp Val His 
1               5                   10                  


<210> 700
<211> 42
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region CDR L1

<400> 700
tctgggagca gttccaacat cggggcaggt tatgatgtcc ac                          42


<210> 701
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region CDR L2

<400> 701
Gly Asn Thr Asn Arg Pro Ser 
1               5           


<210> 702
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region CDR L2

<400> 702
ggtaacacca atcggccctc a                                                 21


<210> 703
<211> 10
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region CDR L3

<400> 703
Gln Ser Tyr Asp Arg Ser Leu Ser Gln Val 
1               5                   10  


<210> 704
<211> 30
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region CDR L3

<400> 704
cagtcctatg acagaagcct gagtcaggtc                                        30


<210> 705
<211> 378
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region

<400> 705
caggtcacct tgaaggagtc tggtcctgcg ctggtgagac ccaaacagac cctcactctg       60

acctgctcct tctccggctt ctcactcgac actcaaagaa cgggtgtgaa ttggatccgt      120

cagtccccag ggaaggccct ggagtggctt gcacggattg attgggatgg caatatttac      180

tccagcacct ctgtgaggac caaactcagc atctccaagg gcacctccaa aaaccaggtg      240

gtccttacaa tgaccgacgt ggaccctgtg gacacagcca cctattactg tgcacggact      300

ctttactata cttctggtgg ttattacttg aacctctttg actactgggg ccaaggaacc      360

ctggtcaccg tctcctca                                                    378


<210> 706
<211> 126
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region

<400> 706
Gln Val Thr Leu Lys Glu Ser Gly Pro Ala Leu Val Arg Pro Lys Gln 
1               5                   10                  15      


Thr Leu Thr Leu Thr Cys Ser Phe Ser Gly Phe Ser Leu Asp Thr Gln 
            20                  25                  30          


Arg Thr Gly Val Asn Trp Ile Arg Gln Ser Pro Gly Lys Ala Leu Glu 
        35                  40                  45              


Trp Leu Ala Arg Ile Asp Trp Asp Gly Asn Ile Tyr Ser Ser Thr Ser 
    50                  55                  60                  


Val Arg Thr Lys Leu Ser Ile Ser Lys Gly Thr Ser Lys Asn Gln Val 
65                  70                  75                  80  


Val Leu Thr Met Thr Asp Val Asp Pro Val Asp Thr Ala Thr Tyr Tyr 
                85                  90                  95      


Cys Ala Arg Thr Leu Tyr Tyr Thr Ser Gly Gly Tyr Tyr Leu Asn Leu 
            100                 105                 110         


Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125     


<210> 707
<211> 11
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H1

<400> 707
Phe Ser Leu Asp Thr Gln Arg Thr Gly Val Asn 
1               5                   10      


<210> 708
<211> 33
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H1

<400> 708
ttctcactcg acactcaaag aacgggtgtg aat                                    33


<210> 709
<211> 16
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H2

<400> 709
Arg Ile Asp Trp Asp Gly Asn Ile Tyr Ser Ser Thr Ser Val Arg Thr 
1               5                   10                  15      


<210> 710
<211> 48
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H2

<400> 710
cggattgatt gggatggcaa tatttactcc agcacctctg tgaggacc                    48


<210> 711
<211> 18
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H3

<400> 711
Ala Arg Thr Leu Tyr Tyr Thr Ser Gly Gly Tyr Tyr Leu Asn Leu Phe 
1               5                   10                  15      


Asp Tyr 
        


<210> 712
<211> 54
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H3

<400> 712
gcacggactc tttactatac ttctggtggt tattacttga acctctttga ctac             54


<210> 713
<211> 321
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region

<400> 713
gaaattgtga tgacgcagtc tccaccctcc ctgtctgcct ctgttgggga cagagtcacc       60

atcacttgcc gggcaagtca gacaattccc agctatgtca attggtatca gcagatatca      120

gggaaagccc ctcgcctcct gatctatgct gcctcacttt tgcaaagtgg ggtcccatca      180

aggttcagtg gcagcggatc tgggacagag ttcagtctca ccatcagcgg tctgcgacct      240

gaggattttg gcacttacta ctgtcaacag agttacagtt ccactcccac tttcggccag      300

gggacacgac tggagattaa a                                                321


<210> 714
<211> 107
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region

<400> 714
Glu Ile Val Met Thr Gln Ser Pro Pro Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Thr Ile Pro Ser Tyr 
            20                  25                  30          


Val Asn Trp Tyr Gln Gln Ile Ser Gly Lys Ala Pro Arg Leu Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Leu Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Glu Phe Ser Leu Thr Ile Ser Gly Leu Arg Pro 
65                  70                  75                  80  


Glu Asp Phe Gly Thr Tyr Tyr Cys Gln Gln Ser Tyr Ser Ser Thr Pro 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Arg Leu Glu Ile Lys 
            100                 105         


<210> 715
<211> 11
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region CDR L1

<400> 715
Arg Ala Ser Gln Thr Ile Pro Ser Tyr Val Asn 
1               5                   10      


<210> 716
<211> 33
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region CDR L1

<400> 716
cgggcaagtc agacaattcc cagctatgtc aat                                    33


<210> 717
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region CDR L2

<400> 717
Ala Ala Ser Leu Leu Gln Ser 
1               5           


<210> 718
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region CDR L2

<400> 718
gctgcctcac ttttgcaaag t                                                 21


<210> 719
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region CDR L3

<400> 719
Gln Gln Ser Tyr Ser Ser Thr Pro Thr 
1               5                   


<210> 720
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region CDR L3

<400> 720
caacagagtt acagttccac tcccact                                           27


<210> 721
<211> 378
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region

<400> 721
gaggtgcagc tggtggagtc tggggctgag gtgaagaggc ctgggtcctc ggtgaaggtc       60

tcctgtaagg ttgtcggagg cagtttcagc aactatgcta tcagctgggt gcgacaggcc      120

cctggacaag ggcctgagta tctgggaggg atcatccccg cctttaggac agcaaaatat      180

gcaaagaaat tccaggacag actcacaatt accgcggacg aatctacgag cactgcctac      240

atggaaatga ggggcctgac atctgacgac acgggcctat attattgtgc gaggcctgaa      300

ggagactttg gggatttgaa gtggctacga tcgccctttg actactgggg ccagggaacc      360

ctggtcaccg tctcctca                                                    378


<210> 722
<211> 126
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region

<400> 722
Glu Val Gln Leu Val Glu Ser Gly Ala Glu Val Lys Arg Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Val Val Gly Gly Ser Phe Ser Asn Tyr 
            20                  25                  30          


Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Pro Glu Tyr Leu 
        35                  40                  45              


Gly Gly Ile Ile Pro Ala Phe Arg Thr Ala Lys Tyr Ala Lys Lys Phe 
    50                  55                  60                  


Gln Asp Arg Leu Thr Ile Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Met Arg Gly Leu Thr Ser Asp Asp Thr Gly Leu Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Pro Glu Gly Asp Phe Gly Asp Leu Lys Trp Leu Arg Ser Pro 
            100                 105                 110         


Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125     


<210> 723
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H1

<400> 723
Gly Ser Phe Ser Asn Tyr Ala Ile Ser 
1               5                   


<210> 724
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H1

<400> 724
ggcagtttca gcaactatgc tatcagc                                           27


<210> 725
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H2

<400> 725
Gly Ile Ile Pro Ala Phe Arg Thr Ala Lys Tyr Ala Lys Lys Phe Gln 
1               5                   10                  15      


Asp 
    


<210> 726
<211> 51
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H2

<400> 726
gggatcatcc ccgcctttag gacagcaaaa tatgcaaaga aattccagga c                51


<210> 727
<211> 19
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H3

<400> 727
Ala Arg Pro Glu Gly Asp Phe Gly Asp Leu Lys Trp Leu Arg Ser Pro 
1               5                   10                  15      


Phe Asp Tyr 
            


<210> 728
<211> 57
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H3

<400> 728
gcgaggcctg aaggagactt tggggatttg aagtggctac gatcgccctt tgactac          57


<210> 729
<211> 327
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region

<400> 729
gaaattgtgt tgacgcagtc tccagccacc ctgtctgtgt ctccagggca aagagtcacc       60

ctttcctgca gggccagtca gggtgtgagc atcaacttag cctggtacca gcagaaacct      120

ggccagcctc ccaggctcct catctatggt gcatccaccc gggccactga tatcccagcc      180

aggttcagtg gcagtgggtc tgggacagac ttcactctca ccatcagcag cctgcagtct      240

gaagattttg cagtttatta ttgtcagcag tatgatgact ggcctcccca gctcactttc      300

ggccctggga ccaagctgga gatcaaa                                          327


<210> 730
<211> 109
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region

<400> 730
Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Val Ser Pro Gly 
1               5                   10                  15      


Gln Arg Val Thr Leu Ser Cys Arg Ala Ser Gln Gly Val Ser Ile Asn 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro Arg Leu Leu Ile 
        35                  40                  45              


Tyr Gly Ala Ser Thr Arg Ala Thr Asp Ile Pro Ala Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Ser 
65                  70                  75                  80  


Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Asp Asp Trp Pro Pro 
                85                  90                  95      


Gln Leu Thr Phe Gly Pro Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 


<210> 731
<211> 11
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region CDR L1

<400> 731
Arg Ala Ser Gln Gly Val Ser Ile Asn Leu Ala 
1               5                   10      


<210> 732
<211> 33
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region CDR L1

<400> 732
agggccagtc agggtgtgag catcaactta gcc                                    33


<210> 733
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region CDR L2

<400> 733
Gly Ala Ser Thr Arg Ala Thr 
1               5           


<210> 734
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region CDR L2

<400> 734
ggtgcatcca cccgggccac t                                                 21


<210> 735
<211> 11
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region CDR L3

<400> 735
Gln Gln Tyr Asp Asp Trp Pro Pro Gln Leu Thr 
1               5                   10      


<210> 736
<211> 33
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region CDR L3

<400> 736
cagcagtatg atgactggcc tccccagctc act                                    33


<210> 737
<211> 384
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region

<400> 737
caggtgcagc tgcaggagtc gggcccagga ctagtgaagc cttcggagac cctgtccctc       60

acctgcactg tctctggtgg ctccatcaat aactacttct ggagctggat ccggcagccc      120

ccagggaagg gactggagtg gcttggatat atctacaaca gtgggagcac ctactacaac      180

ccctccctca acagtcgagt caccatctca ttacaaaagt ccaagaacca gttctccctg      240

cacctgacgt ccatgaccgc cgccgatacg gccgtgtatt tctgtgcgag acatccaagt      300

gtgatctacg ggactttcgg cgccaacggg gggccaaact ggttcgaccc ctggggccag      360

ggaaccctgg tcaccgtctc ctca                                             384


<210> 738
<211> 128
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region

<400> 738
Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Gly Ser Ile Asn Asn Tyr 
            20                  25                  30          


Phe Trp Ser Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Leu 
        35                  40                  45              


Gly Tyr Ile Tyr Asn Ser Gly Ser Thr Tyr Tyr Asn Pro Ser Leu Asn 
    50                  55                  60                  


Ser Arg Val Thr Ile Ser Leu Gln Lys Ser Lys Asn Gln Phe Ser Leu 
65                  70                  75                  80  


His Leu Thr Ser Met Thr Ala Ala Asp Thr Ala Val Tyr Phe Cys Ala 
                85                  90                  95      


Arg His Pro Ser Val Ile Tyr Gly Thr Phe Gly Ala Asn Gly Gly Pro 
            100                 105                 110         


Asn Trp Phe Asp Pro Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125             


<210> 739
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H1

<400> 739
Gly Ser Ile Asn Asn Tyr Phe Trp Ser 
1               5                   


<210> 740
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H1

<400> 740
ggctccatca ataactactt ctggagc                                           27


<210> 741
<211> 16
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H2

<400> 741
Tyr Ile Tyr Asn Ser Gly Ser Thr Tyr Tyr Asn Pro Ser Leu Asn Ser 
1               5                   10                  15      


<210> 742
<211> 48
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H2

<400> 742
tatatctaca acagtgggag cacctactac aacccctccc tcaacagt                    48


<210> 743
<211> 22
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H3

<400> 743
Ala Arg His Pro Ser Val Ile Tyr Gly Thr Phe Gly Ala Asn Gly Gly 
1               5                   10                  15      


Pro Asn Trp Phe Asp Pro 
            20          


<210> 744
<211> 66
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H3

<400> 744
gcgagacatc caagtgtgat ctacgggact ttcggcgcca acggggggcc aaactggttc       60

gacccc                                                                  66


<210> 745
<211> 330
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region

<400> 745
cagtctgttc tgactcagcc tgcctccgtg tctgggtctc ctggacagtc gatcaccatc       60

tcctgcactg gaaccagcag tgacgttggt ggttataact atgtctcctg gtaccaacaa      120

cacccaggca aggcccccaa actcatgatt ttcgatgtca cttatcggcc ctcagggatt      180

tctaatcgct tctctggctc caagtctggc aacacggcct ccctgaccat ctctgggctc      240

cactctgagg acgaggctga ttattattgc agctcatata caggcagcaa caccgtgatt      300

ttcggcggag ggaccaagct gaccgtccta                                       330


<210> 746
<211> 110
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region

<400> 746
Gln Ser Val Leu Thr Gln Pro Ala Ser Val Ser Gly Ser Pro Gly Gln 
1               5                   10                  15      


Ser Ile Thr Ile Ser Cys Thr Gly Thr Ser Ser Asp Val Gly Gly Tyr 
            20                  25                  30          


Asn Tyr Val Ser Trp Tyr Gln Gln His Pro Gly Lys Ala Pro Lys Leu 
        35                  40                  45              


Met Ile Phe Asp Val Thr Tyr Arg Pro Ser Gly Ile Ser Asn Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Asn Thr Ala Ser Leu Thr Ile Ser Gly Leu 
65                  70                  75                  80  


His Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ser Ser Tyr Thr Gly Ser 
                85                  90                  95      


Asn Thr Val Ile Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 110 


<210> 747
<211> 14
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region CDR L1

<400> 747
Thr Gly Thr Ser Ser Asp Val Gly Gly Tyr Asn Tyr Val Ser 
1               5                   10                  


<210> 748
<211> 42
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region CDR L1

<400> 748
actggaacca gcagtgacgt tggtggttat aactatgtct cc                          42


<210> 749
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region CDR L2

<400> 749
Asp Val Thr Tyr Arg Pro Ser 
1               5           


<210> 750
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region CDR L2

<400> 750
gatgtcactt atcggccctc a                                                 21


<210> 751
<211> 10
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region CDR L3

<400> 751
Ser Ser Tyr Thr Gly Ser Asn Thr Val Ile 
1               5                   10  


<210> 752
<211> 30
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region CDR L3

<400> 752
agctcatata caggcagcaa caccgtgatt                                        30


<210> 753
<211> 366
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region

<400> 753
caggtccagc ttgtacagtc tggggctgaa gtgaagaagc ctggggcctc agtgagggtc       60

tcctgcaagg cttctggcta caccttcagc agctactata ttcactgggt gcgacaggcc      120

cctggacaag ggcctgagtg gctgggatgg atcaacccaa agagtggtga cacaatctat      180

tcatataagt ttcagggcag ggtcaccttg accagggaaa cgtcaatcac cacagcctac      240

atggagttga ccagtctgag atctgacgac acggccgtct attactgtgc gcgagttact      300

tggcagtggc tggtcctggg gggttttgac tactggggcc agggaaccct ggtcaccgtc      360

tcctca                                                                 366


<210> 754
<211> 122
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region

<400> 754
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Arg Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Ser Ser Tyr 
            20                  25                  30          


Tyr Ile His Trp Val Arg Gln Ala Pro Gly Gln Gly Pro Glu Trp Leu 
        35                  40                  45              


Gly Trp Ile Asn Pro Lys Ser Gly Asp Thr Ile Tyr Ser Tyr Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Leu Thr Arg Glu Thr Ser Ile Thr Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Thr Ser Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Val Thr Trp Gln Trp Leu Val Leu Gly Gly Phe Asp Tyr Trp 
            100                 105                 110         


Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120         


<210> 755
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H1

<400> 755
Tyr Thr Phe Ser Ser Tyr Tyr Ile His 
1               5                   


<210> 756
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H1

<400> 756
tacaccttca gcagctacta tattcac                                           27


<210> 757
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H2

<400> 757
Trp Ile Asn Pro Lys Ser Gly Asp Thr Ile Tyr Ser Tyr Lys Phe Gln 
1               5                   10                  15      


Gly 
    


<210> 758
<211> 51
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H2

<400> 758
tggatcaacc caaagagtgg tgacacaatc tattcatata agtttcaggg c                51


<210> 759
<211> 15
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H3

<400> 759
Ala Arg Val Thr Trp Gln Trp Leu Val Leu Gly Gly Phe Asp Tyr 
1               5                   10                  15  


<210> 760
<211> 45
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H3

<400> 760
gcgcgagtta cttggcagtg gctggtcctg gggggttttg actac                       45


<210> 761
<211> 336
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region

<400> 761
gatattgtgc tgactcagtc tccactctcc ctgcccgtca cccctggaga gccggcctcc       60

atctcctgca ggtctagtct gagcctcctg catagtaatg gagacaacta tttggattgg      120

tacctgcaga agccagggca gtctccacag ctcctgatct atttgggttc taatcgggcc      180

tccggggtcc ctgacaggtt cagtggcagt ggatcaggca cagattttac actgaaaatc      240

agccgagtgg aggctgagga tgttggggtt tattactgca tgcaagctct acacactccc      300

ctcactttcg gcggagggac caagctggag atcaaa                                336


<210> 762
<211> 112
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region

<400> 762
Asp Ile Val Leu Thr Gln Ser Pro Leu Ser Leu Pro Val Thr Pro Gly 
1               5                   10                  15      


Glu Pro Ala Ser Ile Ser Cys Arg Ser Ser Leu Ser Leu Leu His Ser 
            20                  25                  30          


Asn Gly Asp Asn Tyr Leu Asp Trp Tyr Leu Gln Lys Pro Gly Gln Ser 
        35                  40                  45              


Pro Gln Leu Leu Ile Tyr Leu Gly Ser Asn Arg Ala Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Met Gln Ala 
                85                  90                  95      


Leu His Thr Pro Leu Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


<210> 763
<211> 16
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region CDR L1

<400> 763
Arg Ser Ser Leu Ser Leu Leu His Ser Asn Gly Asp Asn Tyr Leu Asp 
1               5                   10                  15      


<210> 764
<211> 48
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region CDR L1

<400> 764
aggtctagtc tgagcctcct gcatagtaat ggagacaact atttggat                    48


<210> 765
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region CDR L2

<400> 765
Leu Gly Ser Asn Arg Ala Ser 
1               5           


<210> 766
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region CDR L2

<400> 766
ttgggttcta atcgggcctc c                                                 21


<210> 767
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region CDR L3

<400> 767
Met Gln Ala Leu His Thr Pro Leu Thr 
1               5                   


<210> 768
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region CDR L3

<400> 768
atgcaagctc tacacactcc cctcact                                           27


<210> 769
<211> 375
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region

<400> 769
gaggtgcagc tggtggagtc tgggggaggc ttggtccagc ctggggggtc cctgaaactc       60

tcctgtactt cctctgggct cgccttcagt ggctctgcta tacactgggt ccgccaggct      120

tccgggaaag ggctggagtg ggttggccgt attagaagca aacctaacag ttacgcgaca      180

gaatatgctg cgtcggtgaa ggggaggttc accatctcca gagatgattc acagaacacg      240

gcgtatctgc aaatgaacag cctgaaagcc gaggacacgg ccctgtatta ctgtacttta      300

ggatattgta gtggtgatag ctgctcctct cttagggact actggggcca gggaaccctg      360

gtcaccgtct cctca                                                       375


<210> 770
<211> 125
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region

<400> 770
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Lys Leu Ser Cys Thr Ser Ser Gly Leu Ala Phe Ser Gly Ser 
            20                  25                  30          


Ala Ile His Trp Val Arg Gln Ala Ser Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Gly Arg Ile Arg Ser Lys Pro Asn Ser Tyr Ala Thr Glu Tyr Ala Ala 
    50                  55                  60                  


Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Gln Asn Thr 
65                  70                  75                  80  


Ala Tyr Leu Gln Met Asn Ser Leu Lys Ala Glu Asp Thr Ala Leu Tyr 
                85                  90                  95      


Tyr Cys Thr Leu Gly Tyr Cys Ser Gly Asp Ser Cys Ser Ser Leu Arg 
            100                 105                 110         


Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125 


<210> 771
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H1

<400> 771
Leu Ala Phe Ser Gly Ser Ala Ile His 
1               5                   


<210> 772
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H1

<400> 772
ctcgccttca gtggctctgc tatacac                                           27


<210> 773
<211> 19
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H2

<400> 773
Arg Ile Arg Ser Lys Pro Asn Ser Tyr Ala Thr Glu Tyr Ala Ala Ser 
1               5                   10                  15      


Val Lys Gly 
            


<210> 774
<211> 57
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H2

<400> 774
cgtattagaa gcaaacctaa cagttacgcg acagaatatg ctgcgtcggt gaagggg          57


<210> 775
<211> 16
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H3

<400> 775
Thr Leu Gly Tyr Cys Ser Gly Asp Ser Cys Ser Ser Leu Arg Asp Tyr 
1               5                   10                  15      


<210> 776
<211> 48
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H3

<400> 776
actttaggat attgtagtgg tgatagctgc tcctctctta gggactac                    48


<210> 777
<211> 330
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region

<400> 777
cagtctgctc tgattcagcc tgcctccgtg tctgggtctc ctggacagtc gatcaccatc       60

tcctgcactg gaaccagcag tgacgttggt ggttataact atgtctcttg gtaccaacag      120

cacccaggca aagcccccaa actcatgatt tatgatgtca gtaatcggcc ctcaggggtt      180

tctaatcgct tctctggctc caagtctggc aacacggcct ccctgaccat ctctgggctc      240

caggctgagg acgaggctga ttattactgc agctcatata caagtagcag cactctcgtg      300

ttcggcggag ggaccaaggt caccgtccta                                       330


<210> 778
<211> 110
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region

<400> 778
Gln Ser Ala Leu Ile Gln Pro Ala Ser Val Ser Gly Ser Pro Gly Gln 
1               5                   10                  15      


Ser Ile Thr Ile Ser Cys Thr Gly Thr Ser Ser Asp Val Gly Gly Tyr 
            20                  25                  30          


Asn Tyr Val Ser Trp Tyr Gln Gln His Pro Gly Lys Ala Pro Lys Leu 
        35                  40                  45              


Met Ile Tyr Asp Val Ser Asn Arg Pro Ser Gly Val Ser Asn Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Asn Thr Ala Ser Leu Thr Ile Ser Gly Leu 
65                  70                  75                  80  


Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Ser Ser Tyr Thr Ser Ser 
                85                  90                  95      


Ser Thr Leu Val Phe Gly Gly Gly Thr Lys Val Thr Val Leu 
            100                 105                 110 


<210> 779
<211> 14
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region CDR L1

<400> 779
Thr Gly Thr Ser Ser Asp Val Gly Gly Tyr Asn Tyr Val Ser 
1               5                   10                  


<210> 780
<211> 42
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region CDR L1

<400> 780
actggaacca gcagtgacgt tggtggttat aactatgtct ct                          42


<210> 781
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region CDR L2

<400> 781
Asp Val Ser Asn Arg Pro Ser 
1               5           


<210> 782
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region CDR L2

<400> 782
gatgtcagta atcggccctc a                                                 21


<210> 783
<211> 10
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region CDR L3

<400> 783
Ser Ser Tyr Thr Ser Ser Ser Thr Leu Val 
1               5                   10  


<210> 784
<211> 30
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region CDR L3

<400> 784
agctcatata caagtagcag cactctcgtg                                        30


<210> 785
<211> 363
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region

<400> 785
caggtccagc tggtgcagtc tggaagtgag gtgaagaagc ctggggcctc ggtgaaggtc       60

tcctgcaagg cctcaggtta caggttttcc aactatggta tcagctgggt gcgacaggcc      120

cctggacaag gcctagagtg gatgggatgg atcagcgctt acaatggaaa cataaagtat      180

ggaaataacc tccagggcag agtcaccgtg accacagaca catccacgac cacggcctac      240

atggaggtga ggagcctgac atctgacgac acggccgtgt attactgtgc gagagatgtc      300

ccagctgacg gggtccactt catggacgtc tggggcaaag ggaccacggt caccgtctcc      360

tca                                                                    363


<210> 786
<211> 121
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region

<400> 786
Gln Val Gln Leu Val Gln Ser Gly Ser Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Arg Phe Ser Asn Tyr 
            20                  25                  30          


Gly Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Ser Ala Tyr Asn Gly Asn Ile Lys Tyr Gly Asn Asn Leu 
    50                  55                  60                  


Gln Gly Arg Val Thr Val Thr Thr Asp Thr Ser Thr Thr Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Val Arg Ser Leu Thr Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Val Pro Ala Asp Gly Val His Phe Met Asp Val Trp Gly 
            100                 105                 110         


Lys Gly Thr Thr Val Thr Val Ser Ser 
        115                 120     


<210> 787
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H1

<400> 787
Tyr Arg Phe Ser Asn Tyr Gly Ile Ser 
1               5                   


<210> 788
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H1

<400> 788
tacaggtttt ccaactatgg tatcagc                                           27


<210> 789
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H2

<400> 789
Trp Ile Ser Ala Tyr Asn Gly Asn Ile Lys Tyr Gly Asn Asn Leu Gln 
1               5                   10                  15      


Gly 
    


<210> 790
<211> 51
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H2

<400> 790
tggatcagcg cttacaatgg aaacataaag tatggaaata acctccaggg c                51


<210> 791
<211> 14
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H3

<400> 791
Ala Arg Asp Val Pro Ala Asp Gly Val His Phe Met Asp Val 
1               5                   10                  


<210> 792
<211> 42
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H3

<400> 792
gcgagagatg tcccagctga cggggtccac ttcatggacg tc                          42


<210> 793
<211> 336
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region

<400> 793
gatattgtga tgactcagac tccactctcc ctgcccgtca cccttggaca gccggcctcc       60

atctcctgca ggtctagtca aagcctcgta cacagtgata ctaacaccta cttgaactgg      120

tttcagcaga ggccaggcca atctccacgg cgcctaattt ataaggtttc taaccgggac      180

tctggggtcc cagacagatt cagcggcagt gggtcaggca ctactttcac actgaaaatc      240

agcagggtgg aggctgagga tgttgggatt tattactgca tgcagggttc acactgggct      300

ccgactttcg gccaggggac caaggtggaa atcaaa                                336


<210> 794
<211> 112
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region

<400> 794
Asp Ile Val Met Thr Gln Thr Pro Leu Ser Leu Pro Val Thr Leu Gly 
1               5                   10                  15      


Gln Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Val His Ser 
            20                  25                  30          


Asp Thr Asn Thr Tyr Leu Asn Trp Phe Gln Gln Arg Pro Gly Gln Ser 
        35                  40                  45              


Pro Arg Arg Leu Ile Tyr Lys Val Ser Asn Arg Asp Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Thr Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Val Gly Ile Tyr Tyr Cys Met Gln Gly 
                85                  90                  95      


Ser His Trp Ala Pro Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105                 110         


<210> 795
<211> 16
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region CDR L1

<400> 795
Arg Ser Ser Gln Ser Leu Val His Ser Asp Thr Asn Thr Tyr Leu Asn 
1               5                   10                  15      


<210> 796
<211> 48
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region CDR L1

<400> 796
aggtctagtc aaagcctcgt acacagtgat actaacacct acttgaac                    48


<210> 797
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region CDR L2

<400> 797
Lys Val Ser Asn Arg Asp Ser 
1               5           


<210> 798
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region CDR L2

<400> 798
aaggtttcta accgggactc t                                                 21


<210> 799
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region CDR L3

<400> 799
Met Gln Gly Ser His Trp Ala Pro Thr 
1               5                   


<210> 800
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region CDR L3

<400> 800
atgcagggtt cacactgggc tccgact                                           27


<210> 801
<211> 366
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region

<400> 801
caggtccagc tggtgcagtc tgggggaggc gtggtccagc ctgggaggtc cctgagactc       60

tcctgtgcag cgtctggatt caccttcagt aactatggca tgcactgggt ccgccaggct      120

ccaggcaagg ggctggagtg ggtggcagtt atatggtatg atggaagtaa taaatactat      180

gcagactccg tgaagggccg attcaccatc tccagagaca attccaagaa cacggtatat      240

ctgcaaatga acagcctgag agccgacgac acggctgtct attactgtgc gagagatgcg      300

atatttggca gtggccccaa ctggttcgac ccctggggtc agggaaccct ggtcaccgtc      360

tcctca                                                                 366


<210> 802
<211> 122
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region

<400> 802
Gln Val Gln Leu Val Gln Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Tyr 
            20                  25                  30          


Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Val Ile Trp Tyr Asp Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Ala Ile Phe Gly Ser Gly Pro Asn Trp Phe Asp Pro Trp 
            100                 105                 110         


Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120         


<210> 803
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H1

<400> 803
Phe Thr Phe Ser Asn Tyr Gly Met His 
1               5                   


<210> 804
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H1

<400> 804
ttcaccttca gtaactatgg catgcac                                           27


<210> 805
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H2

<400> 805
Val Ile Trp Tyr Asp Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210> 806
<211> 51
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H2

<400> 806
gttatatggt atgatggaag taataaatac tatgcagact ccgtgaaggg c                51


<210> 807
<211> 15
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H3

<400> 807
Ala Arg Asp Ala Ile Phe Gly Ser Gly Pro Asn Trp Phe Asp Pro 
1               5                   10                  15  


<210> 808
<211> 45
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H3

<400> 808
gcgagagatg cgatatttgg cagtggcccc aactggttcg acccc                       45


<210> 809
<211> 333
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region

<400> 809
cagtctgtcc tgacgcagcc gccctcagtg tctggggccc cagggcagag ggtcaccatc       60

tcctgcactg ggagcagctc caacatcggg gcaggttatg atgtacactg gtaccagcag      120

cttccaggaa cagcccccaa actcctcatc tatggtagca gcaatcggcc ctcaggggtc      180

cctgaccggt tctctggctc caagtctggc acctcagcct ccctggccat cactgggctc      240

caggctgagg atgaggctga ttattactgc cagtcctatg aaagcagcct gagaggttgg      300

gtgttcggcg gagggaccaa ggtcaccgtc cta                                   333


<210> 810
<211> 111
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region

<400> 810
Gln Ser Val Leu Thr Gln Pro Pro Ser Val Ser Gly Ala Pro Gly Gln 
1               5                   10                  15      


Arg Val Thr Ile Ser Cys Thr Gly Ser Ser Ser Asn Ile Gly Ala Gly 
            20                  25                  30          


Tyr Asp Val His Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu 
        35                  40                  45              


Leu Ile Tyr Gly Ser Ser Asn Arg Pro Ser Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Thr Gly Leu 
65                  70                  75                  80  


Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Gln Ser Tyr Glu Ser Ser 
                85                  90                  95      


Leu Arg Gly Trp Val Phe Gly Gly Gly Thr Lys Val Thr Val Leu 
            100                 105                 110     


<210> 811
<211> 14
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region CDR L1

<400> 811
Thr Gly Ser Ser Ser Asn Ile Gly Ala Gly Tyr Asp Val His 
1               5                   10                  


<210> 812
<211> 42
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region CDR L1

<400> 812
actgggagca gctccaacat cggggcaggt tatgatgtac ac                          42


<210> 813
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region CDR L2

<400> 813
Gly Ser Ser Asn Arg Pro Ser 
1               5           


<210> 814
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region CDR L2

<400> 814
ggtagcagca atcggccctc a                                                 21


<210> 815
<211> 11
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region CDR L3

<400> 815
Gln Ser Tyr Glu Ser Ser Leu Arg Gly Trp Val 
1               5                   10      


<210> 816
<211> 33
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region CDR L3

<400> 816
cagtcctatg aaagcagcct gagaggttgg gtg                                    33


<210> 817
<211> 351
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region

<400> 817
gaggtgcagc tggtggagtc ggggggaggc gtggtccagc ctgggaggtc cctgagactc       60

tcctgtgcag cctctggatt caccttcagt gaccatgcta tgtactgggt ccgccaggct      120

ccaggcaaag ggctagagtg ggtggcactt atatcatttg atggaaggaa tatatactac      180

gcagactccg tgaagggccg attcaccatc tccagagaca attccaagaa cacgctgtat      240

ctgcagatga acagcctgag agctgaggac acggctgtct attactgtgc gagagatcaa      300

tggctggttc ctgactactg gggccaggga accctggtca ccgtctcctc a               351


<210> 818
<211> 117
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region

<400> 818
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp His 
            20                  25                  30          


Ala Met Tyr Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Leu Ile Ser Phe Asp Gly Arg Asn Ile Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Gln Trp Leu Val Pro Asp Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210> 819
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H1

<400> 819
Phe Thr Phe Ser Asp His Ala Met Tyr 
1               5                   


<210> 820
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H1

<400> 820
ttcaccttca gtgaccatgc tatgtac                                           27


<210> 821
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H2

<400> 821
Leu Ile Ser Phe Asp Gly Arg Asn Ile Tyr Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210> 822
<211> 51
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H2

<400> 822
cttatatcat ttgatggaag gaatatatac tacgcagact ccgtgaaggg c                51


<210> 823
<211> 10
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H3

<400> 823
Ala Arg Asp Gln Trp Leu Val Pro Asp Tyr 
1               5                   10  


<210> 824
<211> 30
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H3

<400> 824
gcgagagatc aatggctggt tcctgactac                                        30


<210> 825
<211> 327
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region

<400> 825
cagtctgttc tgactcagcc tgcctccgtg tctgggtctc ctggacagtc gatcaccatc       60

tcctgcactg gaaccagcag tgacgttggt ggttataact atgtctcctg gtaccaacag      120

cacccaggca acgcccccaa actcatgatt tatgaagtca gtaagcggcc ctcaggggtc      180

cctgatcgct tctctggctt caagtctggc aacacggcct ccctgaccgt ctctgggctc      240

caggctgagg atgaggctga ttattactgc agctcatatg caggcagcaa cagtgtcttc      300

ggaactggga ccaaggtcac cgtccta                                          327


<210> 826
<211> 109
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region

<400> 826
Gln Ser Val Leu Thr Gln Pro Ala Ser Val Ser Gly Ser Pro Gly Gln 
1               5                   10                  15      


Ser Ile Thr Ile Ser Cys Thr Gly Thr Ser Ser Asp Val Gly Gly Tyr 
            20                  25                  30          


Asn Tyr Val Ser Trp Tyr Gln Gln His Pro Gly Asn Ala Pro Lys Leu 
        35                  40                  45              


Met Ile Tyr Glu Val Ser Lys Arg Pro Ser Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Phe Lys Ser Gly Asn Thr Ala Ser Leu Thr Val Ser Gly Leu 
65                  70                  75                  80  


Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Ser Ser Tyr Ala Gly Ser 
                85                  90                  95      


Asn Ser Val Phe Gly Thr Gly Thr Lys Val Thr Val Leu 
            100                 105                 


<210> 827
<211> 14
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region CDR L1

<400> 827
Thr Gly Thr Ser Ser Asp Val Gly Gly Tyr Asn Tyr Val Ser 
1               5                   10                  


<210> 828
<211> 42
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region CDR L1

<400> 828
actggaacca gcagtgacgt tggtggttat aactatgtct cc                          42


<210> 829
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region CDR L2

<400> 829
Glu Val Ser Lys Arg Pro Ser 
1               5           


<210> 830
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region CDR L2

<400> 830
gaagtcagta agcggccctc a                                                 21


<210> 831
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region CDR L3

<400> 831
Ser Ser Tyr Ala Gly Ser Asn Ser Val 
1               5                   


<210> 832
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region CDR L3

<400> 832
agctcatatg caggcagcaa cagtgtc                                           27


<210> 833
<211> 384
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region

<400> 833
gaggtgcagc tggtggagtc tgggggaggc ttggtaaggc cgggggggtc ccttggactc       60

tcatgttcag cctctggatt cattttcagt aacgcttgga tgacctgggt ccgccaggct      120

ccagggaagg gactggagtg ggtcggccat attaaaagca aagttaatgg tgggacaaca      180

gcctacggtg cacccgtgaa aggcagattc accatctcaa gagatgattc acgaaacacg      240

ctgtttctgc aaatgaacag cctgaaaacc gaggacacag gcgtgtatta ctgtactaca      300

ggcccaccct atcagtactt tgatgattcc ggttattcgg tcgtggacta ctggggccag      360

ggaaccctgg tcaccgtctc ctcc                                             384


<210> 834
<211> 128
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region

<400> 834
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Arg Pro Gly Gly 
1               5                   10                  15      


Ser Leu Gly Leu Ser Cys Ser Ala Ser Gly Phe Ile Phe Ser Asn Ala 
            20                  25                  30          


Trp Met Thr Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Gly His Ile Lys Ser Lys Val Asn Gly Gly Thr Thr Ala Tyr Gly Ala 
    50                  55                  60                  


Pro Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Arg Asn Thr 
65                  70                  75                  80  


Leu Phe Leu Gln Met Asn Ser Leu Lys Thr Glu Asp Thr Gly Val Tyr 
                85                  90                  95      


Tyr Cys Thr Thr Gly Pro Pro Tyr Gln Tyr Phe Asp Asp Ser Gly Tyr 
            100                 105                 110         


Ser Val Val Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125             


<210> 835
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H1

<400> 835
Phe Ile Phe Ser Asn Ala Trp Met Thr 
1               5                   


<210> 836
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H1

<400> 836
ttcattttca gtaacgcttg gatgacc                                           27


<210> 837
<211> 19
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H2

<400> 837
His Ile Lys Ser Lys Val Asn Gly Gly Thr Thr Ala Tyr Gly Ala Pro 
1               5                   10                  15      


Val Lys Gly 
            


<210> 838
<211> 57
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H2

<400> 838
catattaaaa gcaaagttaa tggtgggaca acagcctacg gtgcacccgt gaaaggc          57


<210> 839
<211> 19
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H3

<400> 839
Thr Thr Gly Pro Pro Tyr Gln Tyr Phe Asp Asp Ser Gly Tyr Ser Val 
1               5                   10                  15      


Val Asp Tyr 
            


<210> 840
<211> 57
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H3

<400> 840
actacaggcc caccctatca gtactttgat gattccggtt attcggtcgt ggactac          57


<210> 841
<211> 330
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region

<400> 841
cagtctgtgg tgacgcagcc gccctcagcg tctgggaccc ccgggcagag ggtcaccatc       60

tcttgttctg gaagcgactc caacatcgga actgattatt tttactggta ccagcagctc      120

ccaggatcgg cccccaaact cctcatctat ggtagtaatc agcggccctc cggggtccct      180

gaccgattct ctggctccca gtctggctcc gcagcctccc tggccatcag tggcctccgg      240

tccgaggatg acgctgacta ttactgtgca gcatgggatg acagcctggg tggtccggtg      300

ttcggcggtg ggaccaaggt caccgtccta                                       330


<210> 842
<211> 110
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region

<400> 842
Gln Ser Val Val Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln 
1               5                   10                  15      


Arg Val Thr Ile Ser Cys Ser Gly Ser Asp Ser Asn Ile Gly Thr Asp 
            20                  25                  30          


Tyr Phe Tyr Trp Tyr Gln Gln Leu Pro Gly Ser Ala Pro Lys Leu Leu 
        35                  40                  45              


Ile Tyr Gly Ser Asn Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gln Ser Gly Ser Ala Ala Ser Leu Ala Ile Ser Gly Leu Arg 
65                  70                  75                  80  


Ser Glu Asp Asp Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Asp Ser Leu 
                85                  90                  95      


Gly Gly Pro Val Phe Gly Gly Gly Thr Lys Val Thr Val Leu 
            100                 105                 110 


<210> 843
<211> 13
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region CDR L1

<400> 843
Ser Gly Ser Asp Ser Asn Ile Gly Thr Asp Tyr Phe Tyr 
1               5                   10              


<210> 844
<211> 39
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region CDR L1

<400> 844
tctggaagcg actccaacat cggaactgat tatttttac                              39


<210> 845
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region CDR L2

<400> 845
Gly Ser Asn Gln Arg Pro Ser 
1               5           


<210> 846
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region CDR L2

<400> 846
ggtagtaatc agcggccctc c                                                 21


<210> 847
<211> 11
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region CDR L3

<400> 847
Ala Ala Trp Asp Asp Ser Leu Gly Gly Pro Val 
1               5                   10      


<210> 848
<211> 33
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region CDR L3

<400> 848
gcagcatggg atgacagcct gggtggtccg gtg                                    33


<210> 849
<211> 366
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region

<400> 849
caggtgcagc tacagcagtg gggcacagga ctggtgaagc cttcggagac cctgtcccta       60

acctgcgcag tctctggtgg ggccttcagc ggtcaccagt ggaactggtt ccgccagccc      120

cccgggaagg gtctggagtg gattggagaa atcaatgtca gtggcaacac ccactacaac      180

gtgtccctca ggagtcgggt caccatttct ctggacgagt ccaagaaaca attctccctg      240

aaaatgacct ctgtcaccgc cgcggatacg gctatttact actgtgcgaa agcctcgagt      300

gggtcttatc acttcgagta ttggttcgac ccctggagcc agggaacaat ggtcaccgtc      360

tcctca                                                                 366


<210> 850
<211> 122
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region

<400> 850
Gln Val Gln Leu Gln Gln Trp Gly Thr Gly Leu Val Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Ala Val Ser Gly Gly Ala Phe Ser Gly His 
            20                  25                  30          


Gln Trp Asn Trp Phe Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Glu Ile Asn Val Ser Gly Asn Thr His Tyr Asn Val Ser Leu Arg 
    50                  55                  60                  


Ser Arg Val Thr Ile Ser Leu Asp Glu Ser Lys Lys Gln Phe Ser Leu 
65                  70                  75                  80  


Lys Met Thr Ser Val Thr Ala Ala Asp Thr Ala Ile Tyr Tyr Cys Ala 
                85                  90                  95      


Lys Ala Ser Ser Gly Ser Tyr His Phe Glu Tyr Trp Phe Asp Pro Trp 
            100                 105                 110         


Ser Gln Gly Thr Met Val Thr Val Ser Ser 
        115                 120         


<210> 851
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H1

<400> 851
Gly Ala Phe Ser Gly His Gln Trp Asn 
1               5                   


<210> 852
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H1

<400> 852
ggggccttca gcggtcacca gtggaac                                           27


<210> 853
<211> 16
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H2

<400> 853
Glu Ile Asn Val Ser Gly Asn Thr His Tyr Asn Val Ser Leu Arg Ser 
1               5                   10                  15      


<210> 854
<211> 48
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H2

<400> 854
gaaatcaatg tcagtggcaa cacccactac aacgtgtccc tcaggagt                    48


<210> 855
<211> 16
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H3

<400> 855
Ala Lys Ala Ser Ser Gly Ser Tyr His Phe Glu Tyr Trp Phe Asp Pro 
1               5                   10                  15      


<210> 856
<211> 48
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H3

<400> 856
gcgaaagcct cgagtgggtc ttatcacttc gagtattggt tcgacccc                    48


<210> 857
<211> 324
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region

<400> 857
tcctatgagc tgacacagcc accctcggtg tcagtggccc caggaaagat ggcctggttt       60

acctgtgggg gaagcgacat tggaagtaaa agagtccact ggtaccagca gaagccgggc      120

caggcccctg tcctgctcgt gtatgatgat tccttacgtc cctcagggac ctctgcccga      180

gtctctggct ccacctctgg caacacggcc accctgagta tcatcagcgt cgaagccggg      240

gatgaggccg actatttttg tcaggtgtgg gatgatgccg acgatcatgc ggtgttcggc      300

ggagggacca agctcaccgt ccta                                             324


<210> 858
<211> 108
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region

<400> 858
Ser Tyr Glu Leu Thr Gln Pro Pro Ser Val Ser Val Ala Pro Gly Lys 
1               5                   10                  15      


Met Ala Trp Phe Thr Cys Gly Gly Ser Asp Ile Gly Ser Lys Arg Val 
            20                  25                  30          


His Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Val Leu Leu Val Tyr 
        35                  40                  45              


Asp Asp Ser Leu Arg Pro Ser Gly Thr Ser Ala Arg Val Ser Gly Ser 
    50                  55                  60                  


Thr Ser Gly Asn Thr Ala Thr Leu Ser Ile Ile Ser Val Glu Ala Gly 
65                  70                  75                  80  


Asp Glu Ala Asp Tyr Phe Cys Gln Val Trp Asp Asp Ala Asp Asp His 
                85                  90                  95      


Ala Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105             


<210> 859
<211> 11
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region CDR L1

<400> 859
Gly Gly Ser Asp Ile Gly Ser Lys Arg Val His 
1               5                   10      


<210> 860
<211> 33
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region CDR L1

<400> 860
gggggaagcg acattggaag taaaagagtc cac                                    33


<210> 861
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region CDR L2

<400> 861
Asp Asp Ser Leu Arg Pro Ser 
1               5           


<210> 862
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region CDR L2

<400> 862
gatgattcct tacgtccctc a                                                 21


<210> 863
<211> 11
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region CDR L3

<400> 863
Gln Val Trp Asp Asp Ala Asp Asp His Ala Val 
1               5                   10      


<210> 864
<211> 33
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region CDR L3

<400> 864
caggtgtggg atgatgccga cgatcatgcg gtg                                    33


<210> 865
<211> 351
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region

<400> 865
gaggtgcagc tggtggagtc ggggggaggc gtggtccagc ctgggaggtc cctgagactc       60

tcctgtgcag cctctggatt caccttcagt gaccatgcta tgtactgggt ccgccaggct      120

ccaggcaaag ggctagagtg ggtggcactt atatcatttg atggaaggaa tatatactac      180

gcagactccg tgaagggccg attcaccatc tccagagaca attccaagaa cacgctgtat      240

ctgcagatga acagcctgag agctgaggac acggctgtct attactgtgc gagagatcaa      300

tggctggttc ctgactactg gggccaggga accctggtca ccgtctcctc a               351


<210> 866
<211> 117
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region

<400> 866
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp His 
            20                  25                  30          


Ala Met Tyr Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Leu Ile Ser Phe Asp Gly Arg Asn Ile Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Gln Trp Leu Val Pro Asp Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210> 867
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H1

<400> 867
Phe Thr Phe Ser Asp His Ala Met Tyr 
1               5                   


<210> 868
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H1

<400> 868
ttcaccttca gtgaccatgc tatgtac                                           27


<210> 869
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H2

<400> 869
Leu Ile Ser Phe Asp Gly Arg Asn Ile Tyr Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210> 870
<211> 51
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H2

<400> 870
cttatatcat ttgatggaag gaatatatac tacgcagact ccgtgaaggg c                51


<210> 871
<211> 10
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H3

<400> 871
Ala Arg Asp Gln Trp Leu Val Pro Asp Tyr 
1               5                   10  


<210> 872
<211> 30
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H3

<400> 872
gcgagagatc aatggctggt tcctgactac                                        30


<210> 873
<211> 327
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region

<400> 873
cagtctgctc tgactcagcc tgcctccgtg tctgggtctc ctggacagtc gatcaccatc       60

tcctgcactg gaaccagcag tgacgttggt ggttataact atgtctcctg gtaccaacag      120

cacccaggca acgcccccaa actcatgatt tatgaagtca gtaagcggcc ctcaggggtc      180

cctgatcgct tctctggctt caagtctggc aacacggcct ccctgaccgt ctctgggctc      240

caggctgagg atgaggctga ttattactgc agctcatatg caggcagcaa cagtgtcttc      300

ggaactggga ccaaggtgac cgtccta                                          327


<210> 874
<211> 109
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region

<400> 874
Gln Ser Ala Leu Thr Gln Pro Ala Ser Val Ser Gly Ser Pro Gly Gln 
1               5                   10                  15      


Ser Ile Thr Ile Ser Cys Thr Gly Thr Ser Ser Asp Val Gly Gly Tyr 
            20                  25                  30          


Asn Tyr Val Ser Trp Tyr Gln Gln His Pro Gly Asn Ala Pro Lys Leu 
        35                  40                  45              


Met Ile Tyr Glu Val Ser Lys Arg Pro Ser Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Phe Lys Ser Gly Asn Thr Ala Ser Leu Thr Val Ser Gly Leu 
65                  70                  75                  80  


Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Ser Ser Tyr Ala Gly Ser 
                85                  90                  95      


Asn Ser Val Phe Gly Thr Gly Thr Lys Val Thr Val Leu 
            100                 105                 


<210> 875
<211> 14
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region CDR L1

<400> 875
Thr Gly Thr Ser Ser Asp Val Gly Gly Tyr Asn Tyr Val Ser 
1               5                   10                  


<210> 876
<211> 42
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region CDR L1

<400> 876
actggaacca gcagtgacgt tggtggttat aactatgtct cc                          42


<210> 877
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region CDR L2

<400> 877
Glu Val Ser Lys Arg Pro Ser 
1               5           


<210> 878
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region CDR L2

<400> 878
gaagtcagta agcggccctc a                                                 21


<210> 879
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region CDR L3

<400> 879
Ser Ser Tyr Ala Gly Ser Asn Ser Val 
1               5                   


<210> 880
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region CDR L3

<400> 880
agctcatatg caggcagcaa cagtgtc                                           27


<210> 881
<211> 378
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region

<400> 881
cagatcacct tgaaggagtc tggtcctacg ctggtgaaac ccacacagac cctcacgctg       60

acctgctcct tctctgggtt ctcactcacc actcgtggag tgggtgtggg ctgggtccgt      120

cagcccccag gaaaggccct ggagtgcctt ggattcgttt attgggacga tgataagcgc      180

tacagcccat ctctgaggag cagactcacc atctccgagg acacgtccaa aaaccaggtg      240

gtccttacaa tgaccaacat ggaccctttg gacacagcca cgtattactg tgtacacagc      300

gatctctatg atagaggtgg ttattactta ttctactttg actactgggg ccagggaacc      360

ctggtcaccg tctcctca                                                    378


<210> 882
<211> 126
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region

<400> 882
Gln Ile Thr Leu Lys Glu Ser Gly Pro Thr Leu Val Lys Pro Thr Gln 
1               5                   10                  15      


Thr Leu Thr Leu Thr Cys Ser Phe Ser Gly Phe Ser Leu Thr Thr Arg 
            20                  25                  30          


Gly Val Gly Val Gly Trp Val Arg Gln Pro Pro Gly Lys Ala Leu Glu 
        35                  40                  45              


Cys Leu Gly Phe Val Tyr Trp Asp Asp Asp Lys Arg Tyr Ser Pro Ser 
    50                  55                  60                  


Leu Arg Ser Arg Leu Thr Ile Ser Glu Asp Thr Ser Lys Asn Gln Val 
65                  70                  75                  80  


Val Leu Thr Met Thr Asn Met Asp Pro Leu Asp Thr Ala Thr Tyr Tyr 
                85                  90                  95      


Cys Val His Ser Asp Leu Tyr Asp Arg Gly Gly Tyr Tyr Leu Phe Tyr 
            100                 105                 110         


Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125     


<210> 883
<211> 11
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H1

<400> 883
Phe Ser Leu Thr Thr Arg Gly Val Gly Val Gly 
1               5                   10      


<210> 884
<211> 33
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H1

<400> 884
ttctcactca ccactcgtgg agtgggtgtg ggc                                    33


<210> 885
<211> 16
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H2

<400> 885
Phe Val Tyr Trp Asp Asp Asp Lys Arg Tyr Ser Pro Ser Leu Arg Ser 
1               5                   10                  15      


<210> 886
<211> 48
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H2

<400> 886
ttcgtttatt gggacgatga taagcgctac agcccatctc tgaggagc                    48


<210> 887
<211> 18
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H3

<400> 887
Val His Ser Asp Leu Tyr Asp Arg Gly Gly Tyr Tyr Leu Phe Tyr Phe 
1               5                   10                  15      


Asp Tyr 
        


<210> 888
<211> 54
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H3

<400> 888
gtacacagcg atctctatga tagaggtggt tattacttat tctactttga ctac             54


<210> 889
<211> 321
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region

<400> 889
gatattgtgc tgactcagtc tccatcctcc ctgtctgcat ctgtggggga cagagtcacc       60

atcacttgcc gggcaagtca gcccattgcc agctatttaa attggtatca gcacaaacca      120

gggaaagccc ctaaactcct gatctatgct gcatccagtt tgcagagtgg ggtctcatca      180

acattcagtg gccggggatc tgggacagat ttcactctca ccatcaccgc tctgcaacct      240

gaagattttg caatttacta ctgtcaacag agttacactt tcccgtacac ttttggccag      300

gggaccaaag tggatatcaa a                                                321


<210> 890
<211> 107
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region

<400> 890
Asp Ile Val Leu Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Pro Ile Ala Ser Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln His Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Ser Ser Thr Phe Ser Gly 
    50                  55                  60                  


Arg Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Thr Ala Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Ile Tyr Tyr Cys Gln Gln Ser Tyr Thr Phe Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Asp Ile Lys 
            100                 105         


<210> 891
<211> 11
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region CDR L1

<400> 891
Arg Ala Ser Gln Pro Ile Ala Ser Tyr Leu Asn 
1               5                   10      


<210> 892
<211> 33
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region CDR L1

<400> 892
cgggcaagtc agcccattgc cagctattta aat                                    33


<210> 893
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region CDR L2

<400> 893
Ala Ala Ser Ser Leu Gln Ser 
1               5           


<210> 894
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region CDR L2

<400> 894
gctgcatcca gtttgcagag t                                                 21


<210> 895
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region CDR L3

<400> 895
Gln Gln Ser Tyr Thr Phe Pro Tyr Thr 
1               5                   


<210> 896
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region CDR L3

<400> 896
caacagagtt acactttccc gtacact                                           27


<210> 897
<211> 354
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region

<400> 897
caggtgcagc tggtgcagtc tggagcagag gtgaagaagc cgggggagtc tctgaagatc       60

tcctgtcaag gttctggata tagttttaga agttactgga tcggttgggt gcgccagaag      120

cccgggaaag gcctggaata tatgggcatc atctttccta atgactttga taccagatac      180

agcccgtcct tccaaggcca ggtcaccatc tccgtcgaca agtccaccag caccgccttc      240

ctgcagtgga ccagcctgca ggcctcggac accgccatat attattgtgg cagacaagag      300

ctgcagggta gttttactat atggggccaa gggacaatgg tcaccgtcac ttca            354


<210> 898
<211> 118
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region

<400> 898
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu 
1               5                   10                  15      


Ser Leu Lys Ile Ser Cys Gln Gly Ser Gly Tyr Ser Phe Arg Ser Tyr 
            20                  25                  30          


Trp Ile Gly Trp Val Arg Gln Lys Pro Gly Lys Gly Leu Glu Tyr Met 
        35                  40                  45              


Gly Ile Ile Phe Pro Asn Asp Phe Asp Thr Arg Tyr Ser Pro Ser Phe 
    50                  55                  60                  


Gln Gly Gln Val Thr Ile Ser Val Asp Lys Ser Thr Ser Thr Ala Phe 
65                  70                  75                  80  


Leu Gln Trp Thr Ser Leu Gln Ala Ser Asp Thr Ala Ile Tyr Tyr Cys 
                85                  90                  95      


Gly Arg Gln Glu Leu Gln Gly Ser Phe Thr Ile Trp Gly Gln Gly Thr 
            100                 105                 110         


Met Val Thr Val Thr Ser 
        115             


<210> 899
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H1

<400> 899
Tyr Ser Phe Arg Ser Tyr Trp Ile Gly 
1               5                   


<210> 900
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H1

<400> 900
tatagtttta gaagttactg gatcggt                                           27


<210> 901
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H2

<400> 901
Ile Ile Phe Pro Asn Asp Phe Asp Thr Arg Tyr Ser Pro Ser Phe Gln 
1               5                   10                  15      


Gly 
    


<210> 902
<211> 51
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H2

<400> 902
atcatctttc ctaatgactt tgataccaga tacagcccgt ccttccaagg c                51


<210> 903
<211> 11
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H3

<400> 903
Gly Arg Gln Glu Leu Gln Gly Ser Phe Thr Ile 
1               5                   10      


<210> 904
<211> 33
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H3

<400> 904
ggcagacaag agctgcaggg tagttttact ata                                    33


<210> 905
<211> 324
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region

<400> 905
gatattgtga tgactcagtc tccatcctcc ctgtccgcat ctgtcggaga cagagtcacc       60

atcacttgcc aggcgagtca ggacatgggc aattctttaa attggtatca gcaaaagtca      120

gggaaagccc ctaaactcct gatctacgat gcatcgtatt tggattcagg ggtcccatca      180

aggttcagtg gcagtggatc tgggacacat tttactttca ccatcagcac cctgcagcct      240

gaagatattg caacatatta ctgtcaacat tatgataatc tcctcttatt cactttcggc      300

cctgggacca agctggagat caaa                                             324


<210> 906
<211> 108
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region

<400> 906
Asp Ile Val Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Gln Ala Ser Gln Asp Met Gly Asn Ser 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Ser Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Asp Ala Ser Tyr Leu Asp Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr His Phe Thr Phe Thr Ile Ser Thr Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Ile Ala Thr Tyr Tyr Cys Gln His Tyr Asp Asn Leu Leu Leu 
                85                  90                  95      


Phe Thr Phe Gly Pro Gly Thr Lys Leu Glu Ile Lys 
            100                 105             


<210> 907
<211> 11
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region CDR L1

<400> 907
Gln Ala Ser Gln Asp Met Gly Asn Ser Leu Asn 
1               5                   10      


<210> 908
<211> 33
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region CDR L1

<400> 908
caggcgagtc aggacatggg caattcttta aat                                    33


<210> 909
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region CDR L2

<400> 909
Asp Ala Ser Tyr Leu Asp Ser 
1               5           


<210> 910
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region CDR L2

<400> 910
gatgcatcgt atttggattc a                                                 21


<210> 911
<211> 10
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region CDR L3

<400> 911
Gln His Tyr Asp Asn Leu Leu Leu Phe Thr 
1               5                   10  


<210> 912
<211> 30
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region CDR L3

<400> 912
caacattatg ataatctcct cttattcact                                        30


<210> 913
<211> 378
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region

<400> 913
cagatcacct tgaaggagtc tggtcctacc ctggtgaaac ccacacagac cctcacgctg       60

acctgcacct tctctgggtt ctcactcacc actcgtggag tgggtgtggg ctggatccgt      120

cagcccccag gaaaggccct ggagttccta ggattcattc attgggatga tgataagacc      180

tacagcccat ctctgaggag gagactcacc atcaccaagg acacctccaa caacgaggtg      240

gtccttacaa tgaccaacat ggaccctgtg gacacagcca catattactg tgtccacagc      300

gatctctatg atagtggtgg ttattactta tactactttg actactgggg ccagggaacc      360

ctggtcaccg tctcctca                                                    378


<210> 914
<211> 126
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region

<400> 914
Gln Ile Thr Leu Lys Glu Ser Gly Pro Thr Leu Val Lys Pro Thr Gln 
1               5                   10                  15      


Thr Leu Thr Leu Thr Cys Thr Phe Ser Gly Phe Ser Leu Thr Thr Arg 
            20                  25                  30          


Gly Val Gly Val Gly Trp Ile Arg Gln Pro Pro Gly Lys Ala Leu Glu 
        35                  40                  45              


Phe Leu Gly Phe Ile His Trp Asp Asp Asp Lys Thr Tyr Ser Pro Ser 
    50                  55                  60                  


Leu Arg Arg Arg Leu Thr Ile Thr Lys Asp Thr Ser Asn Asn Glu Val 
65                  70                  75                  80  


Val Leu Thr Met Thr Asn Met Asp Pro Val Asp Thr Ala Thr Tyr Tyr 
                85                  90                  95      


Cys Val His Ser Asp Leu Tyr Asp Ser Gly Gly Tyr Tyr Leu Tyr Tyr 
            100                 105                 110         


Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125     


<210> 915
<211> 11
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H1

<400> 915
Phe Ser Leu Thr Thr Arg Gly Val Gly Val Gly 
1               5                   10      


<210> 916
<211> 33
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H1

<400> 916
ttctcactca ccactcgtgg agtgggtgtg ggc                                    33


<210> 917
<211> 16
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H2

<400> 917
Phe Ile His Trp Asp Asp Asp Lys Thr Tyr Ser Pro Ser Leu Arg Arg 
1               5                   10                  15      


<210> 918
<211> 48
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H2

<400> 918
ttcattcatt gggatgatga taagacctac agcccatctc tgaggagg                    48


<210> 919
<211> 18
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H3

<400> 919
Val His Ser Asp Leu Tyr Asp Ser Gly Gly Tyr Tyr Leu Tyr Tyr Phe 
1               5                   10                  15      


Asp Tyr 
        


<210> 920
<211> 54
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H3

<400> 920
gtccacagcg atctctatga tagtggtggt tattacttat actactttga ctac             54


<210> 921
<211> 321
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region

<400> 921
gaaattgtga tgacacagtc tccatcctcc ctgtctgcat ctgtggggga cagagtcacc       60

atcacttgcc gggcaagtca gcccattccc agttatgtaa attggtatca gcagagacca      120

gggaaagccc ctaagctcct gatctatgct gcatccaatt tgcagagtgg ggtctcatca      180

aaatttagtg gcaggggatt tgggacagat ttcactctca ccatcgacac tctgcaacct      240

gaagattttg caacttacta ctgtcaacag gtttacactt ccccgtacac ttttggccag      300

gggaccaagc tggagatcaa a                                                321


<210> 922
<211> 107
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region

<400> 922
Glu Ile Val Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Pro Ile Pro Ser Tyr 
            20                  25                  30          


Val Asn Trp Tyr Gln Gln Arg Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Asn Leu Gln Ser Gly Val Ser Ser Lys Phe Ser Gly 
    50                  55                  60                  


Arg Gly Phe Gly Thr Asp Phe Thr Leu Thr Ile Asp Thr Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Val Tyr Thr Ser Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210> 923
<211> 11
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region CDR L1

<400> 923
Arg Ala Ser Gln Pro Ile Pro Ser Tyr Val Asn 
1               5                   10      


<210> 924
<211> 33
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region CDR L1

<400> 924
cgggcaagtc agcccattcc cagttatgta aat                                    33


<210> 925
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region CDR L2

<400> 925
Ala Ala Ser Asn Leu Gln Ser 
1               5           


<210> 926
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region CDR L2

<400> 926
gctgcatcca atttgcagag t                                                 21


<210> 927
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region CDR L3

<400> 927
Gln Gln Val Tyr Thr Ser Pro Tyr Thr 
1               5                   


<210> 928
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region CDR L3

<400> 928
caacaggttt acacttcccc gtacact                                           27


<210> 929
<211> 378
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region

<400> 929
gaggtgcagc tggtggagtc tggtcctacg ctggtgaagc ccacacagac cctcacgctg       60

acctgcacct tctctgggtt ctcactcacc actcgtggaa tgggtgtggg ctggatccgt      120

cagcccccag gcaggtccct ggaatggctt gcagtcattt attgggatgg tgatgtgcgc      180

tacagtccat ctctgaaggg caggctcacc atcaccaaag acacccccaa aaaccaggtg      240

gtccttacaa tgaccaacat ggaccctgtg gacacagcca catattactg tgtacacagc      300

gatctctatg ataggaatgc ttattacctg cactactttg acttctgggg ccaaggaacc      360

ctggtcaccg tctcctca                                                    378


<210> 930
<211> 126
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region

<400> 930
Glu Val Gln Leu Val Glu Ser Gly Pro Thr Leu Val Lys Pro Thr Gln 
1               5                   10                  15      


Thr Leu Thr Leu Thr Cys Thr Phe Ser Gly Phe Ser Leu Thr Thr Arg 
            20                  25                  30          


Gly Met Gly Val Gly Trp Ile Arg Gln Pro Pro Gly Arg Ser Leu Glu 
        35                  40                  45              


Trp Leu Ala Val Ile Tyr Trp Asp Gly Asp Val Arg Tyr Ser Pro Ser 
    50                  55                  60                  


Leu Lys Gly Arg Leu Thr Ile Thr Lys Asp Thr Pro Lys Asn Gln Val 
65                  70                  75                  80  


Val Leu Thr Met Thr Asn Met Asp Pro Val Asp Thr Ala Thr Tyr Tyr 
                85                  90                  95      


Cys Val His Ser Asp Leu Tyr Asp Arg Asn Ala Tyr Tyr Leu His Tyr 
            100                 105                 110         


Phe Asp Phe Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125     


<210> 931
<211> 11
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H1

<400> 931
Phe Ser Leu Thr Thr Arg Gly Met Gly Val Gly 
1               5                   10      


<210> 932
<211> 33
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H1

<400> 932
ttctcactca ccactcgtgg aatgggtgtg ggc                                    33


<210> 933
<211> 16
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H2

<400> 933
Val Ile Tyr Trp Asp Gly Asp Val Arg Tyr Ser Pro Ser Leu Lys Gly 
1               5                   10                  15      


<210> 934
<211> 48
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H2

<400> 934
gtcatttatt gggatggtga tgtgcgctac agtccatctc tgaagggc                    48


<210> 935
<211> 18
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H3

<400> 935
Val His Ser Asp Leu Tyr Asp Arg Asn Ala Tyr Tyr Leu His Tyr Phe 
1               5                   10                  15      


Asp Phe 
        


<210> 936
<211> 54
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H3

<400> 936
gtacacagcg atctctatga taggaatgct tattacctgc actactttga cttc             54


<210> 937
<211> 321
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region

<400> 937
gacatccggt tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga cagagtcacc       60

atcacttgcc gggcaagtca gattattgcc agttatttaa attggtatca gcagaaacca      120

gggaaagccc ctaacctcct gatctttgct gcatccagtt tgcaaagtgg ggtcccatca      180

aggttccgtg gcagtggatc tgggacagat ttcactctca ccataagcag tctgcaacct      240

gaagactttg caacttacta ctgtcaacag agttacagta taccgtacac ttttggccag      300

gggaccaagc tggagatcaa a                                                321


<210> 938
<211> 107
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region

<400> 938
Asp Ile Arg Leu Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ile Ile Ala Ser Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Asn Leu Leu Ile 
        35                  40                  45              


Phe Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Arg Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Tyr Ser Ile Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210> 939
<211> 11
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region CDR L1

<400> 939
Arg Ala Ser Gln Ile Ile Ala Ser Tyr Leu Asn 
1               5                   10      


<210> 940
<211> 33
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region CDR L1

<400> 940
cgggcaagtc agattattgc cagttattta aat                                    33


<210> 941
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region CDR L2

<400> 941
Ala Ala Ser Ser Leu Gln Ser 
1               5           


<210> 942
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region CDR L2

<400> 942
gctgcatcca gtttgcaaag t                                                 21


<210> 943
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region CDR L3

<400> 943
Gln Gln Ser Tyr Ser Ile Pro Tyr Thr 
1               5                   


<210> 944
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region CDR L3

<400> 944
caacagagtt acagtatacc gtacact                                           27


<210> 945
<211> 378
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region

<400> 945
caggtccagc tggtgcagtc tggtcctgca ctggtgaaac ccacacagac cctcacgctg       60

acctgcacct tctctggatt ctcactcacc actcgtggag tgggtgtggg ctggatccgt      120

cagaccccag gaaaggccct ggagtgcctt ggattcattt attgggatga tgatatgaac      180

tacaacccat ctctgagggg cagagtcacc atcaccaggg acacctccaa aaaccaggtg      240

gtcctaacaa tgaccaacat ggcccctgtg gacacaggca catattactg tgtacacagc      300

gatctctatg atagtagcgg ttattattta tattactttg actactgggg ccagggaacc      360

ctggtcaccg tctcctca                                                    378


<210> 946
<211> 126
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region

<400> 946
Gln Val Gln Leu Val Gln Ser Gly Pro Ala Leu Val Lys Pro Thr Gln 
1               5                   10                  15      


Thr Leu Thr Leu Thr Cys Thr Phe Ser Gly Phe Ser Leu Thr Thr Arg 
            20                  25                  30          


Gly Val Gly Val Gly Trp Ile Arg Gln Thr Pro Gly Lys Ala Leu Glu 
        35                  40                  45              


Cys Leu Gly Phe Ile Tyr Trp Asp Asp Asp Met Asn Tyr Asn Pro Ser 
    50                  55                  60                  


Leu Arg Gly Arg Val Thr Ile Thr Arg Asp Thr Ser Lys Asn Gln Val 
65                  70                  75                  80  


Val Leu Thr Met Thr Asn Met Ala Pro Val Asp Thr Gly Thr Tyr Tyr 
                85                  90                  95      


Cys Val His Ser Asp Leu Tyr Asp Ser Ser Gly Tyr Tyr Leu Tyr Tyr 
            100                 105                 110         


Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125     


<210> 947
<211> 11
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H1

<400> 947
Phe Ser Leu Thr Thr Arg Gly Val Gly Val Gly 
1               5                   10      


<210> 948
<211> 33
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H1

<400> 948
ttctcactca ccactcgtgg agtgggtgtg ggc                                    33


<210> 949
<211> 16
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H2

<400> 949
Phe Ile Tyr Trp Asp Asp Asp Met Asn Tyr Asn Pro Ser Leu Arg Gly 
1               5                   10                  15      


<210> 950
<211> 48
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H2

<400> 950
ttcatttatt gggatgatga tatgaactac aacccatctc tgaggggc                    48


<210> 951
<211> 18
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H3

<400> 951
Val His Ser Asp Leu Tyr Asp Ser Ser Gly Tyr Tyr Leu Tyr Tyr Phe 
1               5                   10                  15      


Asp Tyr 
        


<210> 952
<211> 54
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H3

<400> 952
gtacacagcg atctctatga tagtagcggt tattatttat attactttga ctac             54


<210> 953
<211> 321
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region

<400> 953
gacatccggt tgacccagtc tccatcctcc ctgtctgcat ctgtggggga cagagtcacc       60

atcacttgcc gggcaagtca gcccattgcc agttatttaa attggtatca gcagaaacca      120

gggaaagccc ctaaactcct gatctatgct gcatccaatt tgcagagtgg ggtcccttca      180

acattcagtg gcaggggatc tgggacagat ttctctctca ccatctccac tctgcaacct      240

gaagacattg caacttacta ctgtcaacag agttacacct ccccctacac ttttggccag      300

gggaccaagg tggagatcaa a                                                321


<210> 954
<211> 107
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region

<400> 954
Asp Ile Arg Leu Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Pro Ile Ala Ser Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Asn Leu Gln Ser Gly Val Pro Ser Thr Phe Ser Gly 
    50                  55                  60                  


Arg Gly Ser Gly Thr Asp Phe Ser Leu Thr Ile Ser Thr Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Ile Ala Thr Tyr Tyr Cys Gln Gln Ser Tyr Thr Ser Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210> 955
<211> 11
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region CDR L1

<400> 955
Arg Ala Ser Gln Pro Ile Ala Ser Tyr Leu Asn 
1               5                   10      


<210> 956
<211> 33
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region CDR L1

<400> 956
cgggcaagtc agcccattgc cagttattta aat                                    33


<210> 957
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region CDR L2

<400> 957
Ala Ala Ser Asn Leu Gln Ser 
1               5           


<210> 958
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region CDR L2

<400> 958
gctgcatcca atttgcagag t                                                 21


<210> 959
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region CDR L3

<400> 959
Gln Gln Ser Tyr Thr Ser Pro Tyr Thr 
1               5                   


<210> 960
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region CDR L3

<400> 960
caacagagtt acacctcccc ctacact                                           27


<210> 961
<211> 384
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region

<400> 961
gaggtgcagc tgttggagtc tgggggaggc ctggttaagc cgggggggtc ccttagactc       60

tcatgtgcag cctctggatt cattttcaat aacgcctgga tgacctgggt ccgccaggct      120

ccagggaggg ggctggagtg ggttggccgt ataaaaacca atgctgatgg tgggactgca      180

gactacagta cacccgtgaa aggcagattc gccatctcaa gagatgattc tacaaacacg      240

ctgtatctgc aaatgaacag cctgaaaacc gaggacacag ccgtctatta ctgtaccaca      300

ggcccaccct ataagtactc tgacagtact ggttattcgg tcgttgacta ctggggccag      360

ggcaccctgg tcactgtctc ttca                                             384


<210> 962
<211> 128
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region

<400> 962
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ile Phe Asn Asn Ala 
            20                  25                  30          


Trp Met Thr Trp Val Arg Gln Ala Pro Gly Arg Gly Leu Glu Trp Val 
        35                  40                  45              


Gly Arg Ile Lys Thr Asn Ala Asp Gly Gly Thr Ala Asp Tyr Ser Thr 
    50                  55                  60                  


Pro Val Lys Gly Arg Phe Ala Ile Ser Arg Asp Asp Ser Thr Asn Thr 
65                  70                  75                  80  


Leu Tyr Leu Gln Met Asn Ser Leu Lys Thr Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Thr Thr Gly Pro Pro Tyr Lys Tyr Ser Asp Ser Thr Gly Tyr 
            100                 105                 110         


Ser Val Val Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125             


<210> 963
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H1

<400> 963
Phe Ile Phe Asn Asn Ala Trp Met Thr 
1               5                   


<210> 964
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H1

<400> 964
ttcattttca ataacgcctg gatgacc                                           27


<210> 965
<211> 19
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H2

<400> 965
Arg Ile Lys Thr Asn Ala Asp Gly Gly Thr Ala Asp Tyr Ser Thr Pro 
1               5                   10                  15      


Val Lys Gly 
            


<210> 966
<211> 57
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H2

<400> 966
cgtataaaaa ccaatgctga tggtgggact gcagactaca gtacacccgt gaaaggc          57


<210> 967
<211> 19
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H3

<400> 967
Thr Thr Gly Pro Pro Tyr Lys Tyr Ser Asp Ser Thr Gly Tyr Ser Val 
1               5                   10                  15      


Val Asp Tyr 
            


<210> 968
<211> 57
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H3

<400> 968
accacaggcc caccctataa gtactctgac agtactggtt attcggtcgt tgactac          57


<210> 969
<211> 330
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region

<400> 969
tcctatgagc tgacgcagcc accctcagcg tctgggaccc ccgggcagag ggtcaccatc       60

tcttgttctg gaagcagctc caacatcgga agtaattatg tatattggta ccagcagctc      120

ccaggaacgg cccccaaact cctcatctat agtactaatc agcggccctc aggggtccct      180

gaccgattct ctggctccca gtctggcacc tcagcctccc tggccatcag tgggctccgg      240

tccgaggatg aggctgatta ttactgtgca gcgtgggatg accgcctgag tggtccggtg      300

ttcggcgggg gcacccagct gaccgtcctc                                       330


<210> 970
<211> 110
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region

<400> 970
Ser Tyr Glu Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln 
1               5                   10                  15      


Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn 
            20                  25                  30          


Tyr Val Tyr Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 
        35                  40                  45              


Ile Tyr Ser Thr Asn Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gln Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Arg 
65                  70                  75                  80  


Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Asp Arg Leu 
                85                  90                  95      


Ser Gly Pro Val Phe Gly Gly Gly Thr Gln Leu Thr Val Leu 
            100                 105                 110 


<210> 971
<211> 13
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region CDR L1

<400> 971
Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn Tyr Val Tyr 
1               5                   10              


<210> 972
<211> 39
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region CDR L1

<400> 972
tctggaagca gctccaacat cggaagtaat tatgtatat                              39


<210> 973
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region CDR L2

<400> 973
Ser Thr Asn Gln Arg Pro Ser 
1               5           


<210> 974
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region CDR L2

<400> 974
agtactaatc agcggccctc a                                                 21


<210> 975
<211> 11
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region CDR L3

<400> 975
Ala Ala Trp Asp Asp Arg Leu Ser Gly Pro Val 
1               5                   10      


<210> 976
<211> 33
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region CDR L3

<400> 976
gcagcgtggg atgaccgcct gagtggtccg gtg                                    33


<210> 977
<211> 363
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region

<400> 977
caggtccagc ttgtgcagtc tggggctgag gtgaagaagc cggggtcctc ggtgaaaatc       60

tcctgtaagg cttctggagg caccttcaaa agtcaagcta ttcactgggt gcgacaggcc      120

cctggacaag ggcttgagtg gatgggaaac atcatcccta cctacggatc accaaacttc      180

gcgcagaggt tcctcggcag ggtcaccttc attgcggacg attccactgg cgctgcctcc      240

atggacctgt ataggctgac atctgaggac acggccgtct attactgtgc gacagccggg      300

tggttcggag aattagtgcg gtttgactcc tggggccagg gaaccctggt caccgtctcc      360

tca                                                                    363


<210> 978
<211> 121
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region

<400> 978
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Ile Ser Cys Lys Ala Ser Gly Gly Thr Phe Lys Ser Gln 
            20                  25                  30          


Ala Ile His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Asn Ile Ile Pro Thr Tyr Gly Ser Pro Asn Phe Ala Gln Arg Phe 
    50                  55                  60                  


Leu Gly Arg Val Thr Phe Ile Ala Asp Asp Ser Thr Gly Ala Ala Ser 
65                  70                  75                  80  


Met Asp Leu Tyr Arg Leu Thr Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Thr Ala Gly Trp Phe Gly Glu Leu Val Arg Phe Asp Ser Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120     


<210> 979
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H1

<400> 979
Gly Thr Phe Lys Ser Gln Ala Ile His 
1               5                   


<210> 980
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H1

<400> 980
ggcaccttca aaagtcaagc tattcac                                           27


<210> 981
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H2

<400> 981
Asn Ile Ile Pro Thr Tyr Gly Ser Pro Asn Phe Ala Gln Arg Phe Leu 
1               5                   10                  15      


Gly 
    


<210> 982
<211> 51
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H2

<400> 982
aacatcatcc ctacctacgg atcaccaaac ttcgcgcaga ggttcctcgg c                51


<210> 983
<211> 14
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H3

<400> 983
Ala Thr Ala Gly Trp Phe Gly Glu Leu Val Arg Phe Asp Ser 
1               5                   10                  


<210> 984
<211> 42
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H3

<400> 984
gcgacagccg ggtggttcgg agaattagtg cggtttgact cc                          42


<210> 985
<211> 324
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region

<400> 985
gatattgtga tgactcagtc tccagccacc ctgtctgtgt ctccagggga aagagccacc       60

ctctcctgca gggccactga gagtattagc agcaacttag cctggtacca gcagaaacct      120

ggccaggctc ccaggctcct catctatggt gcatccacca gggccactgg tatcccagcc      180

aggttcagtg gcagtgggtc agggacagag ttcactctca ccatcaacag cctgcagtct      240

gaagattttg cagtttatta ctgtcagcag tataataact ggcctcctct cactttcggc      300

ggagggacca aagtggatat caaa                                             324


<210> 986
<211> 108
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region

<400> 986
Asp Ile Val Met Thr Gln Ser Pro Ala Thr Leu Ser Val Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Thr Glu Ser Ile Ser Ser Asn 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 
        35                  40                  45              


Tyr Gly Ala Ser Thr Arg Ala Thr Gly Ile Pro Ala Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Asn Ser Leu Gln Ser 
65                  70                  75                  80  


Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Asn Asn Trp Pro Pro 
                85                  90                  95      


Leu Thr Phe Gly Gly Gly Thr Lys Val Asp Ile Lys 
            100                 105             


<210> 987
<211> 11
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region CDR L1

<400> 987
Arg Ala Thr Glu Ser Ile Ser Ser Asn Leu Ala 
1               5                   10      


<210> 988
<211> 33
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region CDR L1

<400> 988
agggccactg agagtattag cagcaactta gcc                                    33


<210> 989
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region CDR L2

<400> 989
Gly Ala Ser Thr Arg Ala Thr 
1               5           


<210> 990
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region CDR L2

<400> 990
ggtgcatcca ccagggccac t                                                 21


<210> 991
<211> 10
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region CDR L3

<400> 991
Gln Gln Tyr Asn Asn Trp Pro Pro Leu Thr 
1               5                   10  


<210> 992
<211> 30
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region CDR L3

<400> 992
cagcagtata ataactggcc tcctctcact                                        30


<210> 993
<211> 369
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region

<400> 993
caggtccagc tggtgcagtc tggggctgag gtgaagaagc ctgggtcctc ggtgaaggtc       60

tcctgcaagg cttcaggaga caccttcagc atgtatgcta tcagctgggt gcgacaggcc      120

cctggacaag gacttgagtg gatgggaggg gtcctcccaa tgttagggac ctcaaactac      180

gcacaacagt tccggggcag agtcacgata acggcggacg gatccacgag cacagcctac      240

atggagatga gcaacctgag atttgaggac acggccgttt attactgtgc gagggtggcc      300

ggtctgggga acagctatgg tcgctacttt gacgtctggg gtcagggaac cctggtcacc      360

gtctcctca                                                              369


<210> 994
<211> 123
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region

<400> 994
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Asp Thr Phe Ser Met Tyr 
            20                  25                  30          


Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Gly Val Leu Pro Met Leu Gly Thr Ser Asn Tyr Ala Gln Gln Phe 
    50                  55                  60                  


Arg Gly Arg Val Thr Ile Thr Ala Asp Gly Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Met Ser Asn Leu Arg Phe Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Val Ala Gly Leu Gly Asn Ser Tyr Gly Arg Tyr Phe Asp Val 
            100                 105                 110         


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120             


<210> 995
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H1

<400> 995
Asp Thr Phe Ser Met Tyr Ala Ile Ser 
1               5                   


<210> 996
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H1

<400> 996
gacaccttca gcatgtatgc tatcagc                                           27


<210> 997
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H2

<400> 997
Gly Val Leu Pro Met Leu Gly Thr Ser Asn Tyr Ala Gln Gln Phe Arg 
1               5                   10                  15      


Gly 
    


<210> 998
<211> 51
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H2

<400> 998
ggggtcctcc caatgttagg gacctcaaac tacgcacaac agttccgggg c                51


<210> 999
<211> 16
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H3

<400> 999
Ala Arg Val Ala Gly Leu Gly Asn Ser Tyr Gly Arg Tyr Phe Asp Val 
1               5                   10                  15      


<210> 1000
<211> 48
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H3

<400> 1000
gcgagggtgg ccggtctggg gaacagctat ggtcgctact ttgacgtc                    48


<210> 1001
<211> 321
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region

<400> 1001
gacatccgga tgacccagtc tccatcttct gtgtctgcat ctattgggga cagagtcacc       60

atcacttgtc gggcgagtca ggatatcagc acctcgttag cctggtatca gcaaagacca      120

gggaaagccc ctaatctcct gatctatgct gcgtccactt tacacagtgg ggtcccatcg      180

aggttcaggg gcagtgaatc tggcccagac ttcactctca ctatcagcag cctgcagcct      240

gaagatgtcg gaacttacta ttgtcaacag gcaaagagtt tcccgtacac ttttggccag      300

gggaccaagc tggagatcaa a                                                321


<210> 1002
<211> 107
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region

<400> 1002
Asp Ile Arg Met Thr Gln Ser Pro Ser Ser Val Ser Ala Ser Ile Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Ile Ser Thr Ser 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Arg Pro Gly Lys Ala Pro Asn Leu Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Thr Leu His Ser Gly Val Pro Ser Arg Phe Arg Gly 
    50                  55                  60                  


Ser Glu Ser Gly Pro Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Val Gly Thr Tyr Tyr Cys Gln Gln Ala Lys Ser Phe Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210> 1003
<211> 11
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region CDR L1

<400> 1003
Arg Ala Ser Gln Asp Ile Ser Thr Ser Leu Ala 
1               5                   10      


<210> 1004
<211> 33
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region CDR L1

<400> 1004
cgggcgagtc aggatatcag cacctcgtta gcc                                    33


<210> 1005
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region CDR L2

<400> 1005
Ala Ala Ser Thr Leu His Ser 
1               5           


<210> 1006
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region CDR L2

<400> 1006
gctgcgtcca ctttacacag t                                                 21


<210> 1007
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region CDR L3

<400> 1007
Gln Gln Ala Lys Ser Phe Pro Tyr Thr 
1               5                   


<210> 1008
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region CDR L3

<400> 1008
caacaggcaa agagtttccc gtacact                                           27


<210> 1009
<211> 375
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region

<400> 1009
caggtccagc ttgtgcagtc tgggggaggc ctggtcaagc ctggggggtc cctgagactc       60

tcctgtgcag cttctggatt cagcctcaca aactacagaa tgaactgggt ccgccaggct      120

ccagggaagg ggctggagtg ggtctcatcc cttaaggatt ctagttctta catctactac      180

gcagactcag tgaagggccg attcaccgtc tccagagacg acgcgaagaa ttcattcttt      240

ttgcaaatga ccaatgtaag agccgaggac acggctgttt attactgtgc gagagaggga      300

tcggacacgg agtattggag gctgacgccc cccatggacg tctggggcaa cgggaccacg      360

gtcaccgtct cctca                                                       375


<210> 1010
<211> 125
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region

<400> 1010
Gln Val Gln Leu Val Gln Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ser Leu Thr Asn Tyr 
            20                  25                  30          


Arg Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ser Leu Lys Asp Ser Ser Ser Tyr Ile Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Val Ser Arg Asp Asp Ala Lys Asn Ser Phe Phe 
65                  70                  75                  80  


Leu Gln Met Thr Asn Val Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Glu Gly Ser Asp Thr Glu Tyr Trp Arg Leu Thr Pro Pro Met 
            100                 105                 110         


Asp Val Trp Gly Asn Gly Thr Thr Val Thr Val Ser Ser 
        115                 120                 125 


<210> 1011
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H1

<400> 1011
Phe Ser Leu Thr Asn Tyr Arg Met Asn 
1               5                   


<210> 1012
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H1

<400> 1012
ttcagcctca caaactacag aatgaac                                           27


<210> 1013
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H2

<400> 1013
Ser Leu Lys Asp Ser Ser Ser Tyr Ile Tyr Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210> 1014
<211> 51
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H2

<400> 1014
tcccttaagg attctagttc ttacatctac tacgcagact cagtgaaggg c                51


<210> 1015
<211> 18
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H3

<400> 1015
Ala Arg Glu Gly Ser Asp Thr Glu Tyr Trp Arg Leu Thr Pro Pro Met 
1               5                   10                  15      


Asp Val 
        


<210> 1016
<211> 54
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H3

<400> 1016
gcgagagagg gatcggacac ggagtattgg aggctgacgc cccccatgga cgtc             54


<210> 1017
<211> 324
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region

<400> 1017
cagtctgtgt tgacgcagcc gccctcggtg tcagtggccc cacgacagac ggccaggatt       60

acctgtgggg agcacaacat tggaactaaa agtgtgcact ggtaccagca gaagccaggc      120

caggcccctg tcctggtcat ctatgatgac agcgaccggc cctcagggat ccctgcgcga      180

ttctctggct ccaactctgg gaacacggcc accctgacca tcagctgggt cgaagccggg      240

gatgaggccg tctattactg tcaggtgtgg gactcaggtg atcatccttg gctgttcggc      300

ggaggcaccc agctgaccgt cctc                                             324


<210> 1018
<211> 108
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region

<400> 1018
Gln Ser Val Leu Thr Gln Pro Pro Ser Val Ser Val Ala Pro Arg Gln 
1               5                   10                  15      


Thr Ala Arg Ile Thr Cys Gly Glu His Asn Ile Gly Thr Lys Ser Val 
            20                  25                  30          


His Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Val Leu Val Ile Tyr 
        35                  40                  45              


Asp Asp Ser Asp Arg Pro Ser Gly Ile Pro Ala Arg Phe Ser Gly Ser 
    50                  55                  60                  


Asn Ser Gly Asn Thr Ala Thr Leu Thr Ile Ser Trp Val Glu Ala Gly 
65                  70                  75                  80  


Asp Glu Ala Val Tyr Tyr Cys Gln Val Trp Asp Ser Gly Asp His Pro 
                85                  90                  95      


Trp Leu Phe Gly Gly Gly Thr Gln Leu Thr Val Leu 
            100                 105             


<210> 1019
<211> 11
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region CDR L1

<400> 1019
Gly Glu His Asn Ile Gly Thr Lys Ser Val His 
1               5                   10      


<210> 1020
<211> 33
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region CDR L1

<400> 1020
ggggagcaca acattggaac taaaagtgtg cac                                    33


<210> 1021
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region CDR L2

<400> 1021
Asp Asp Ser Asp Arg Pro Ser 
1               5           


<210> 1022
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region CDR L2

<400> 1022
gatgacagcg accggccctc a                                                 21


<210> 1023
<211> 11
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region CDR L3

<400> 1023
Gln Val Trp Asp Ser Gly Asp His Pro Trp Leu 
1               5                   10      


<210> 1024
<211> 33
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region CDR L3

<400> 1024
caggtgtggg actcaggtga tcatccttgg ctg                                    33


<210> 1025
<211> 366
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region

<400> 1025
gaggtgcagc tggtggagtc agggggaggc ttggtacagc cgggggggtc cctgagactc       60

tcctgtgcag cctctggatt ccccttcagt cgttataaca tgaactgggt ccgccaggct      120

ccagggaagg ggctggagtg ggtttcatac attagtagtg gtagtcgaag catttactac      180

gcagactctg tgaagggccg attcaccatc tccagagaca atgccaagaa ctcactgtat      240

ctgcaaatga acagcctgag agccgaggac acggctgtat attactgtgc gagagactta      300

agcggatctc cagcatatag cggcagctgg gtctggggcc agggaaccct ggtcaccgtc      360

tcctca                                                                 366


<210> 1026
<211> 122
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region

<400> 1026
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Pro Phe Ser Arg Tyr 
            20                  25                  30          


Asn Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Tyr Ile Ser Ser Gly Ser Arg Ser Ile Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Leu Ser Gly Ser Pro Ala Tyr Ser Gly Ser Trp Val Trp 
            100                 105                 110         


Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120         


<210> 1027
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H1

<400> 1027
Phe Pro Phe Ser Arg Tyr Asn Met Asn 
1               5                   


<210> 1028
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H1

<400> 1028
ttccccttca gtcgttataa catgaac                                           27


<210> 1029
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H2

<400> 1029
Tyr Ile Ser Ser Gly Ser Arg Ser Ile Tyr Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210> 1030
<211> 51
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H2

<400> 1030
tacattagta gtggtagtcg aagcatttac tacgcagact ctgtgaaggg c                51


<210> 1031
<211> 15
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H3

<400> 1031
Ala Arg Asp Leu Ser Gly Ser Pro Ala Tyr Ser Gly Ser Trp Val 
1               5                   10                  15  


<210> 1032
<211> 45
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H3

<400> 1032
gcgagagact taagcggatc tccagcatat agcggcagct gggtc                       45


<210> 1033
<211> 324
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region

<400> 1033
gaaacgacac tcacgcagtc tccagccacc ctgtctgtgt ctccagggga aagagccacc       60

ctctcctgca gggccagtca gagtgttagc agcaacttag cctggtacca gcagaaacct      120

ggccaggctc ccaggctcct catctatgat gcatccacca gggccactgg tatcccagac      180

aggttcagtg gcagtgggtc tgggacagag ttcactctca ccatcagcag cctgcagtct      240

gaagactttg cactttatta ctgtcagcag tatgataggt ggcctccgtg gacgttcggc      300

caagggacca aggtggaaat caaa                                             324


<210> 1034
<211> 108
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region

<400> 1034
Glu Thr Thr Leu Thr Gln Ser Pro Ala Thr Leu Ser Val Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Asn 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 
        35                  40                  45              


Tyr Asp Ala Ser Thr Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Ser 
65                  70                  75                  80  


Glu Asp Phe Ala Leu Tyr Tyr Cys Gln Gln Tyr Asp Arg Trp Pro Pro 
                85                  90                  95      


Trp Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105             


<210> 1035
<211> 11
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region CDR L1

<400> 1035
Arg Ala Ser Gln Ser Val Ser Ser Asn Leu Ala 
1               5                   10      


<210> 1036
<211> 33
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region CDR L1

<400> 1036
agggccagtc agagtgttag cagcaactta gcc                                    33


<210> 1037
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region CDR L2

<400> 1037
Asp Ala Ser Thr Arg Ala Thr 
1               5           


<210> 1038
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region CDR L2

<400> 1038
gatgcatcca ccagggccac t                                                 21


<210> 1039
<211> 10
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region CDR L3

<400> 1039
Gln Gln Tyr Asp Arg Trp Pro Pro Trp Thr 
1               5                   10  


<210> 1040
<211> 30
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region CDR L3

<400> 1040
cagcagtatg ataggtggcc tccgtggacg                                        30


<210> 1041
<211> 378
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region

<400> 1041
caggtccagc tggtgcagtc tggggctgag gtgaagaagc ctggggcctc agtgaaggtc       60

tcctgcaagg cttctggaaa ctccttcaac gacttttata tgcactgggt gcgacaggcc      120

cctggacaag ggcttgagtg gatgggatgg atcgacccta acaacggagg cgcaaactat      180

gcacagaagt ttcatggcag ggtcactatg accagggact cgtccatcaa cacagcctac      240

atggagttga gcaggctgag atccgacgac acggccgtct attactgtgc gagcgagccc      300

cccggcgttg gttttggatt gattccccac tactactttg acaactgggg ccagggaacc      360

ctggtcaccg tctcctca                                                    378


<210> 1042
<211> 126
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region

<400> 1042
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Asn Ser Phe Asn Asp Phe 
            20                  25                  30          


Tyr Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Asp Pro Asn Asn Gly Gly Ala Asn Tyr Ala Gln Lys Phe 
    50                  55                  60                  


His Gly Arg Val Thr Met Thr Arg Asp Ser Ser Ile Asn Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Arg Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ser Glu Pro Pro Gly Val Gly Phe Gly Leu Ile Pro His Tyr Tyr 
            100                 105                 110         


Phe Asp Asn Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125     


<210> 1043
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H1

<400> 1043
Asn Ser Phe Asn Asp Phe Tyr Met His 
1               5                   


<210> 1044
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H1

<400> 1044
aactccttca acgactttta tatgcac                                           27


<210> 1045
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H2

<400> 1045
Trp Ile Asp Pro Asn Asn Gly Gly Ala Asn Tyr Ala Gln Lys Phe His 
1               5                   10                  15      


Gly 
    


<210> 1046
<211> 51
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H2

<400> 1046
tggatcgacc ctaacaacgg aggcgcaaac tatgcacaga agtttcatgg c                51


<210> 1047
<211> 19
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H3

<400> 1047
Ala Ser Glu Pro Pro Gly Val Gly Phe Gly Leu Ile Pro His Tyr Tyr 
1               5                   10                  15      


Phe Asp Asn 
            


<210> 1048
<211> 57
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H3

<400> 1048
gcgagcgagc cccccggcgt tggttttgga ttgattcccc actactactt tgacaac          57


<210> 1049
<211> 339
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region

<400> 1049
gaaattgtga tgacacagtc tccagactcc ctggctgtgt ctctgggcga gagggccacc       60

atcaactgca agtccagcca gaatgtttta gacacctcca acaataagaa ctacttagct      120

tggtaccagc agaaaccagg acagcctcct agactgctca tttactgggc atctgcccgc      180

ggatccgggg tccctgaccg attcagtggc agcgggtctg ggacacattt cactctcacc      240

atcagcagcc tgcaggctga agatgtggca gtttattact gtcagcaata ttttagtatt      300

cctccgacgt tcggccaagg gaccaaggtg gagatcaaa                             339


<210> 1050
<211> 113
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region

<400> 1050
Glu Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Glu Arg Ala Thr Ile Asn Cys Lys Ser Ser Gln Asn Val Leu Asp Thr 
            20                  25                  30          


Ser Asn Asn Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Pro Pro Arg Leu Leu Ile Tyr Trp Ala Ser Ala Arg Gly Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr His Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Leu Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys Gln Gln 
                85                  90                  95      


Tyr Phe Ser Ile Pro Pro Thr Phe Gly Gln Gly Thr Lys Val Glu Ile 
            100                 105                 110         


Lys 
    


<210> 1051
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region CDR L1

<400> 1051
Lys Ser Ser Gln Asn Val Leu Asp Thr Ser Asn Asn Lys Asn Tyr Leu 
1               5                   10                  15      


Ala 
    


<210> 1052
<211> 51
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region CDR L1

<400> 1052
aagtccagcc agaatgtttt agacacctcc aacaataaga actacttagc t                51


<210> 1053
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region CDR L2

<400> 1053
Trp Ala Ser Ala Arg Gly Ser 
1               5           


<210> 1054
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region CDR L2

<400> 1054
tgggcatctg cccgcggatc c                                                 21


<210> 1055
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region CDR L3

<400> 1055
Gln Gln Tyr Phe Ser Ile Pro Pro Thr 
1               5                   


<210> 1056
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region CDR L3

<400> 1056
cagcaatatt ttagtattcc tccgacg                                           27


<210> 1057
<211> 378
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region

<400> 1057
caggtccagc tggtgcagtc tggggctgag gtgaagaagc ctgggtcctc ggtgaaggtc       60

tcctgcaagg ttgccggagg ctccttctcc aattatgcaa tcgcctggct gcgacaggcc      120

cctggacaag ggcttgagtg gatgggaggt atcatccctg cctttaacag agcaatgtat      180

gcacggaagt tccaagacag agtcacaatt accgcgtacg catcaacgac cactgcctac      240

ctggacatta ccggcctcag atctgaggac acggcccttt attattgtgc gaggcctgct      300

ggagactttg gggatttaaa gtgggtacga tcgccttttg actactgggg ccagggaacc      360

ctgatcaccg tctcctca                                                    378


<210> 1058
<211> 126
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region

<400> 1058
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Val Ala Gly Gly Ser Phe Ser Asn Tyr 
            20                  25                  30          


Ala Ile Ala Trp Leu Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Gly Ile Ile Pro Ala Phe Asn Arg Ala Met Tyr Ala Arg Lys Phe 
    50                  55                  60                  


Gln Asp Arg Val Thr Ile Thr Ala Tyr Ala Ser Thr Thr Thr Ala Tyr 
65                  70                  75                  80  


Leu Asp Ile Thr Gly Leu Arg Ser Glu Asp Thr Ala Leu Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Pro Ala Gly Asp Phe Gly Asp Leu Lys Trp Val Arg Ser Pro 
            100                 105                 110         


Phe Asp Tyr Trp Gly Gln Gly Thr Leu Ile Thr Val Ser Ser 
        115                 120                 125     


<210> 1059
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H1

<400> 1059
Gly Ser Phe Ser Asn Tyr Ala Ile Ala 
1               5                   


<210> 1060
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H1

<400> 1060
ggctccttct ccaattatgc aatcgcc                                           27


<210> 1061
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H2

<400> 1061
Gly Ile Ile Pro Ala Phe Asn Arg Ala Met Tyr Ala Arg Lys Phe Gln 
1               5                   10                  15      


Asp 
    


<210> 1062
<211> 51
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H2

<400> 1062
ggtatcatcc ctgcctttaa cagagcaatg tatgcacgga agttccaaga c                51


<210> 1063
<211> 19
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H3

<400> 1063
Ala Arg Pro Ala Gly Asp Phe Gly Asp Leu Lys Trp Val Arg Ser Pro 
1               5                   10                  15      


Phe Asp Tyr 
            


<210> 1064
<211> 57
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H3

<400> 1064
gcgaggcctg ctggagactt tggggattta aagtgggtac gatcgccttt tgactac          57


<210> 1065
<211> 327
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region

<400> 1065
gatattgtga tgacgcagac tccaggcacc ctgtctgtgt ctccagggga aagagccacc       60

ctctcctgca gggccagtca ggacgttggc atcaacttag cctggtatca gcagaagcct      120

ggccaggctc ccaggctcct catatatggt gcatccacca gggccactga tgtcccagcc      180

aagttcagtg gcagtgggtc tgggacagac ttcactctca ccatcagcag cctgcagtct      240

gaagattttg gagtttatta ttgtcaggag tataatgact ggcctcccca gctctctttc      300

ggccctggga ccaaagtgga tatcaaa                                          327


<210> 1066
<211> 109
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region

<400> 1066
Asp Ile Val Met Thr Gln Thr Pro Gly Thr Leu Ser Val Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Asp Val Gly Ile Asn 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 
        35                  40                  45              


Tyr Gly Ala Ser Thr Arg Ala Thr Asp Val Pro Ala Lys Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Ser 
65                  70                  75                  80  


Glu Asp Phe Gly Val Tyr Tyr Cys Gln Glu Tyr Asn Asp Trp Pro Pro 
                85                  90                  95      


Gln Leu Ser Phe Gly Pro Gly Thr Lys Val Asp Ile Lys 
            100                 105                 


<210> 1067
<211> 11
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region CDR L1

<400> 1067
Arg Ala Ser Gln Asp Val Gly Ile Asn Leu Ala 
1               5                   10      


<210> 1068
<211> 33
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region CDR L1

<400> 1068
agggccagtc aggacgttgg catcaactta gcc                                    33


<210> 1069
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region CDR L2

<400> 1069
Gly Ala Ser Thr Arg Ala Thr 
1               5           


<210> 1070
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region CDR L2

<400> 1070
ggtgcatcca ccagggccac t                                                 21


<210> 1071
<211> 11
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region CDR L3

<400> 1071
Gln Glu Tyr Asn Asp Trp Pro Pro Gln Leu Ser 
1               5                   10      


<210> 1072
<211> 33
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region CDR L3

<400> 1072
caggagtata atgactggcc tccccagctc tct                                    33


<210> 1073
<211> 378
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region

<400> 1073
cagatcacct tgaaggagtc tggtcctacg ctggtgaaac ccacacagac cctcacactg       60

acctgcaccc tctctgggtt ctcactcagc actcctagaa tgggtgtggg ctggatccgt      120

cagcccccag gaaaggccct ggagtggctt gcactcattg attgggatga tgataggcgc      180

tacagtccat ctctgaagac caggctcacc atcaccaagg acacttccaa aaatcaggtg      240

gtccttagaa tgaccgacat ggaccctgtg gacacaggca catattactg tgtacacagc      300

gatgtctata ctactggtgg ttattacttg tactactttg actactgggg ccagggaacc      360

ctggtcaccg tctcctca                                                    378


<210> 1074
<211> 126
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region

<400> 1074
Gln Ile Thr Leu Lys Glu Ser Gly Pro Thr Leu Val Lys Pro Thr Gln 
1               5                   10                  15      


Thr Leu Thr Leu Thr Cys Thr Leu Ser Gly Phe Ser Leu Ser Thr Pro 
            20                  25                  30          


Arg Met Gly Val Gly Trp Ile Arg Gln Pro Pro Gly Lys Ala Leu Glu 
        35                  40                  45              


Trp Leu Ala Leu Ile Asp Trp Asp Asp Asp Arg Arg Tyr Ser Pro Ser 
    50                  55                  60                  


Leu Lys Thr Arg Leu Thr Ile Thr Lys Asp Thr Ser Lys Asn Gln Val 
65                  70                  75                  80  


Val Leu Arg Met Thr Asp Met Asp Pro Val Asp Thr Gly Thr Tyr Tyr 
                85                  90                  95      


Cys Val His Ser Asp Val Tyr Thr Thr Gly Gly Tyr Tyr Leu Tyr Tyr 
            100                 105                 110         


Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125     


<210> 1075
<211> 11
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H1

<400> 1075
Phe Ser Leu Ser Thr Pro Arg Met Gly Val Gly 
1               5                   10      


<210> 1076
<211> 33
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H1

<400> 1076
ttctcactca gcactcctag aatgggtgtg ggc                                    33


<210> 1077
<211> 16
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H2

<400> 1077
Leu Ile Asp Trp Asp Asp Asp Arg Arg Tyr Ser Pro Ser Leu Lys Thr 
1               5                   10                  15      


<210> 1078
<211> 48
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H2

<400> 1078
ctcattgatt gggatgatga taggcgctac agtccatctc tgaagacc                    48


<210> 1079
<211> 18
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H3

<400> 1079
Val His Ser Asp Val Tyr Thr Thr Gly Gly Tyr Tyr Leu Tyr Tyr Phe 
1               5                   10                  15      


Asp Tyr 
        


<210> 1080
<211> 54
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H3

<400> 1080
gtacacagcg atgtctatac tactggtggt tattacttgt actactttga ctac             54


<210> 1081
<211> 321
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region

<400> 1081
gacatccagg tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga cagagtcacc       60

atcacttgcc gggcaagtca gaccattccc agctatttaa attggtatca gcacaaacca      120

gggaaagccc ctcagctcct gatctatgct gcatccaatt tgcgaagtgg ggtcccaccg      180

aggttccgtg gcagtggatc tgggacagat ttcactctca ccgtcagcag tctgcaacct      240

gaagattttg caacttactt ctgtcaacag agttacagta gcccatacac ttttggccag      300

gggaccaagc tggagatcaa a                                                321


<210> 1082
<211> 107
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region

<400> 1082
Asp Ile Gln Val Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Thr Ile Pro Ser Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln His Lys Pro Gly Lys Ala Pro Gln Leu Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Asn Leu Arg Ser Gly Val Pro Pro Arg Phe Arg Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Val Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Phe Cys Gln Gln Ser Tyr Ser Ser Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210> 1083
<211> 11
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region CDR L1

<400> 1083
Arg Ala Ser Gln Thr Ile Pro Ser Tyr Leu Asn 
1               5                   10      


<210> 1084
<211> 33
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region CDR L1

<400> 1084
cgggcaagtc agaccattcc cagctattta aat                                    33


<210> 1085
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region CDR L2

<400> 1085
Ala Ala Ser Asn Leu Arg Ser 
1               5           


<210> 1086
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region CDR L2

<400> 1086
gctgcatcca atttgcgaag t                                                 21


<210> 1087
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region CDR L3

<400> 1087
Gln Gln Ser Tyr Ser Ser Pro Tyr Thr 
1               5                   


<210> 1088
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region CDR L3

<400> 1088
caacagagtt acagtagccc atacact                                           27


<210> 1089
<211> 357
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region

<400> 1089
caggtccagc tggtacagtc tggaactgag gtgaagaagc ctggggcctc agtgaaggtc       60

tcctgcaagg gctctggtta catgtttgca aattttggtg tcagctgggt gcgacaggcc      120

cctggacgag ggcttgagtg gatcggatgg atcagcgctt acaatggaaa cacatactat      180

ggacgtgagc agggcagatt caccatgacc acagacacga acacagccta cctggagctg      240

acgagtctca gatatgacga cacggccctt tatttctgtg cgagagattc gggagcgacg      300

gcggctggaa tactctggga ctattggggc cagggaaccc tggtcaccgt ctcctca         357


<210> 1090
<211> 119
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region

<400> 1090
Gln Val Gln Leu Val Gln Ser Gly Thr Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Gly Ser Gly Tyr Met Phe Ala Asn Phe 
            20                  25                  30          


Gly Val Ser Trp Val Arg Gln Ala Pro Gly Arg Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Trp Ile Ser Ala Tyr Asn Gly Asn Thr Tyr Tyr Gly Arg Glu Gln 
    50                  55                  60                  


Gly Arg Phe Thr Met Thr Thr Asp Thr Asn Thr Ala Tyr Leu Glu Leu 
65                  70                  75                  80  


Thr Ser Leu Arg Tyr Asp Asp Thr Ala Leu Tyr Phe Cys Ala Arg Asp 
                85                  90                  95      


Ser Gly Ala Thr Ala Ala Gly Ile Leu Trp Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210> 1091
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H1

<400> 1091
Tyr Met Phe Ala Asn Phe Gly Val Ser 
1               5                   


<210> 1092
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H1

<400> 1092
tacatgtttg caaattttgg tgtcagc                                           27


<210> 1093
<211> 16
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H2

<400> 1093
Trp Ile Ser Ala Tyr Asn Gly Asn Thr Tyr Tyr Gly Arg Glu Gln Gly 
1               5                   10                  15      


<210> 1094
<211> 48
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H2

<400> 1094
tggatcagcg cttacaatgg aaacacatac tatggacgtg agcagggc                    48


<210> 1095
<211> 15
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H3

<400> 1095
Ala Arg Asp Ser Gly Ala Thr Ala Ala Gly Ile Leu Trp Asp Tyr 
1               5                   10                  15  


<210> 1096
<211> 45
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H3

<400> 1096
gcgagagatt cgggagcgac ggcggctgga atactctggg actat                       45


<210> 1097
<211> 336
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region

<400> 1097
gaaattgtaa tgacacagtc tccactctcc ctgcccgtca cccttggaca gccggcctcc       60

atctcctgca ggtctagtca aagcctcgca tacactgatg gaagcactta cttgaattgg      120

tttcaccaga ggccaggcca gtctccacgg cgcctaattt ataaggtttt taaccgggac      180

tctggggtcc ccgacagatt cagcggcagt ggggcaggca ctgatttcac actgactatc      240

agcagggtgg aggctgagga tgttggggtt tattactgca tgcaagctac acactggcct      300

cggacgttcg gccaggggac caaagtggat atcaaa                                336


<210> 1098
<211> 112
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region

<400> 1098
Glu Ile Val Met Thr Gln Ser Pro Leu Ser Leu Pro Val Thr Leu Gly 
1               5                   10                  15      


Gln Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Ala Tyr Thr 
            20                  25                  30          


Asp Gly Ser Thr Tyr Leu Asn Trp Phe His Gln Arg Pro Gly Gln Ser 
        35                  40                  45              


Pro Arg Arg Leu Ile Tyr Lys Val Phe Asn Arg Asp Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ala Gly Thr Asp Phe Thr Leu Thr Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Met Gln Ala 
                85                  90                  95      


Thr His Trp Pro Arg Thr Phe Gly Gln Gly Thr Lys Val Asp Ile Lys 
            100                 105                 110         


<210> 1099
<211> 16
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region CDR L1

<400> 1099
Arg Ser Ser Gln Ser Leu Ala Tyr Thr Asp Gly Ser Thr Tyr Leu Asn 
1               5                   10                  15      


<210> 1100
<211> 48
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region CDR L1

<400> 1100
aggtctagtc aaagcctcgc atacactgat ggaagcactt acttgaat                    48


<210> 1101
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region CDR L2

<400> 1101
Lys Val Phe Asn Arg Asp Ser 
1               5           


<210> 1102
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region CDR L2

<400> 1102
aaggttttta accgggactc t                                                 21


<210> 1103
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region CDR L3

<400> 1103
Met Gln Ala Thr His Trp Pro Arg Thr 
1               5                   


<210> 1104
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region CDR L3

<400> 1104
atgcaagcta cacactggcc tcggacg                                           27


<210> 1105
<211> 357
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region

<400> 1105
caggtccagc tggtacagtc tggaagtgag gtgaagaagc ctggggcctc ggtgacgctc       60

tcctgcaagg cctcaggtta caggttttcc aactatggtg tcagctgggt gcgacaggcc      120

cccggacaag gcctagagtg gatgggatgg atcagcggtt acaatggaaa cataaagtat      180

ggaaacagtc tccagggcag agtcaccctg accacagaca cgaccacggc ctacatggag      240

gtgacgagcc taacatctga cgacacggcc gtgtattact gtgcgagaga tgtcccagct      300

gacggggtcc acttcatgga cgtctggggc aaagggacca cggtcaccgt ctcctca         357


<210> 1106
<211> 119
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region

<400> 1106
Gln Val Gln Leu Val Gln Ser Gly Ser Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Thr Leu Ser Cys Lys Ala Ser Gly Tyr Arg Phe Ser Asn Tyr 
            20                  25                  30          


Gly Val Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Ser Gly Tyr Asn Gly Asn Ile Lys Tyr Gly Asn Ser Leu 
    50                  55                  60                  


Gln Gly Arg Val Thr Leu Thr Thr Asp Thr Thr Thr Ala Tyr Met Glu 
65                  70                  75                  80  


Val Thr Ser Leu Thr Ser Asp Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
                85                  90                  95      


Asp Val Pro Ala Asp Gly Val His Phe Met Asp Val Trp Gly Lys Gly 
            100                 105                 110         


Thr Thr Val Thr Val Ser Ser 
        115                 


<210> 1107
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H1

<400> 1107
Tyr Arg Phe Ser Asn Tyr Gly Val Ser 
1               5                   


<210> 1108
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H1

<400> 1108
tacaggtttt ccaactatgg tgtcagc                                           27


<210> 1109
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H2

<400> 1109
Trp Ile Ser Gly Tyr Asn Gly Asn Ile Lys Tyr Gly Asn Ser Leu Gln 
1               5                   10                  15      


Gly 
    


<210> 1110
<211> 51
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H2

<400> 1110
tggatcagcg gttacaatgg aaacataaag tatggaaaca gtctccaggg c                51


<210> 1111
<211> 14
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H3

<400> 1111
Ala Arg Asp Val Pro Ala Asp Gly Val His Phe Met Asp Val 
1               5                   10                  


<210> 1112
<211> 42
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H3

<400> 1112
gcgagagatg tcccagctga cggggtccac ttcatggacg tc                          42


<210> 1113
<211> 336
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region

<400> 1113
gaaattgtat tgacgcagtc tccactctcc ctgcccgtca cccttggaca gccggcctcc       60

atctcctgca ggtctagtca aagcctcgtc cacagtgata ctaacaccta cttgacctgg      120

tttcagcaga ggccaggcca atctccacgg cgcctaattt ataaggtttc tcaccgggac      180

tctggggtcc cagacagatt cagcggcagt gggtcaggca caactttcac gctgaaaatc      240

gccagggtgg aggctgagga tgttgggatt tattactgca tggaggggtc acactgggct      300

ccgactttcg gccaggggac caaagtggat atcaaa                                336


<210> 1114
<211> 112
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region

<400> 1114
Glu Ile Val Leu Thr Gln Ser Pro Leu Ser Leu Pro Val Thr Leu Gly 
1               5                   10                  15      


Gln Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Val His Ser 
            20                  25                  30          


Asp Thr Asn Thr Tyr Leu Thr Trp Phe Gln Gln Arg Pro Gly Gln Ser 
        35                  40                  45              


Pro Arg Arg Leu Ile Tyr Lys Val Ser His Arg Asp Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Thr Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ala Arg Val Glu Ala Glu Asp Val Gly Ile Tyr Tyr Cys Met Glu Gly 
                85                  90                  95      


Ser His Trp Ala Pro Thr Phe Gly Gln Gly Thr Lys Val Asp Ile Lys 
            100                 105                 110         


<210> 1115
<211> 16
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region CDR L1

<400> 1115
Arg Ser Ser Gln Ser Leu Val His Ser Asp Thr Asn Thr Tyr Leu Thr 
1               5                   10                  15      


<210> 1116
<211> 48
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region CDR L1

<400> 1116
aggtctagtc aaagcctcgt ccacagtgat actaacacct acttgacc                    48


<210> 1117
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region CDR L2

<400> 1117
Lys Val Ser His Arg Asp Ser 
1               5           


<210> 1118
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region CDR L2

<400> 1118
aaggtttctc accgggactc t                                                 21


<210> 1119
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region CDR L3

<400> 1119
Met Glu Gly Ser His Trp Ala Pro Thr 
1               5                   


<210> 1120
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region CDR L3

<400> 1120
atggaggggt cacactgggc tccgact                                           27


<210> 1121
<211> 384
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region

<400> 1121
caggtgcagc tacagcagtg gggggccgag gtgaagaagc ctgggtcatc ggtgaaggtc       60

tcctgcaagg cttctggagt cgccttgagc agcgttgcaa tcagctgggt gcgacaggcc      120

cctggacaag ggcttgagtg gatgggaggg atcctccctg ggtttgacaa ggtcagattt      180

gcccaggagt ttgagaatag agccactcta accgcggaca cagctaggga tatagcctac      240

atggagttga gcggactgag atctgacgac acggccgtct actactgtgc gataatcgac      300

ccccaagatt gcactagtgc cagctgcttt tgggtcaact ggctcgaccc ctggggccag      360

ggaaccctgg tcaccgtctc ctca                                             384


<210> 1122
<211> 128
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region

<400> 1122
Gln Val Gln Leu Gln Gln Trp Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Val Ala Leu Ser Ser Val 
            20                  25                  30          


Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Gly Ile Leu Pro Gly Phe Asp Lys Val Arg Phe Ala Gln Glu Phe 
    50                  55                  60                  


Glu Asn Arg Ala Thr Leu Thr Ala Asp Thr Ala Arg Asp Ile Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Gly Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ile Ile Asp Pro Gln Asp Cys Thr Ser Ala Ser Cys Phe Trp Val 
            100                 105                 110         


Asn Trp Leu Asp Pro Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125             


<210> 1123
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H1

<400> 1123
Val Ala Leu Ser Ser Val Ala Ile Ser 
1               5                   


<210> 1124
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H1

<400> 1124
gtcgccttga gcagcgttgc aatcagc                                           27


<210> 1125
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H2

<400> 1125
Gly Ile Leu Pro Gly Phe Asp Lys Val Arg Phe Ala Gln Glu Phe Glu 
1               5                   10                  15      


Asn 
    


<210> 1126
<211> 51
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H2

<400> 1126
gggatcctcc ctgggtttga caaggtcaga tttgcccagg agtttgagaa t                51


<210> 1127
<211> 21
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H3

<400> 1127
Ala Ile Ile Asp Pro Gln Asp Cys Thr Ser Ala Ser Cys Phe Trp Val 
1               5                   10                  15      


Asn Trp Leu Asp Pro 
            20      


<210> 1128
<211> 63
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H3

<400> 1128
gcgataatcg acccccaaga ttgcactagt gccagctgct tttgggtcaa ctggctcgac       60

ccc                                                                     63


<210> 1129
<211> 324
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region

<400> 1129
gaaacgacac tcacgcagtc tccaggcacc ctgaccgtgt ctccagggga gagagccacc       60

ctctcctgca gggccagtca gagtattatt agaaacaacc tagcctggta ccagcagaaa      120

cctggccagg ctcccaggct cctcatctat gctgcatcca atagggccac tgacatccca      180

gacaggttca gtggcagtgg gtctgggaca gacttcactc tcaccatcag cagactggaa      240

gcacaagatt ttgcagtgta tttctgtcag cagtatggta cctctccgat caccttcggc      300

caagggacca aggtggaaat caaa                                             324


<210> 1130
<211> 108
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region

<400> 1130
Glu Thr Thr Leu Thr Gln Ser Pro Gly Thr Leu Thr Val Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Ile Ile Arg Asn 
            20                  25                  30          


Asn Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu 
        35                  40                  45              


Ile Tyr Ala Ala Ser Asn Arg Ala Thr Asp Ile Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu 
65                  70                  75                  80  


Ala Gln Asp Phe Ala Val Tyr Phe Cys Gln Gln Tyr Gly Thr Ser Pro 
                85                  90                  95      


Ile Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105             


<210> 1131
<211> 12
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region CDR L1

<400> 1131
Arg Ala Ser Gln Ser Ile Ile Arg Asn Asn Leu Ala 
1               5                   10          


<210> 1132
<211> 36
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region CDR L1

<400> 1132
agggccagtc agagtattat tagaaacaac ctagcc                                 36


<210> 1133
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region CDR L2

<400> 1133
Ala Ala Ser Asn Arg Ala Thr 
1               5           


<210> 1134
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region CDR L2

<400> 1134
gctgcatcca atagggccac t                                                 21


<210> 1135
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region CDR L3

<400> 1135
Gln Gln Tyr Gly Thr Ser Pro Ile Thr 
1               5                   


<210> 1136
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region CDR L3

<400> 1136
cagcagtatg gtacctctcc gatcacc                                           27


<210> 1137
<211> 378
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region

<400> 1137
gaggtgcagc tgttggagtc tggggctgag gtgaagaagc ctgggtcctc ggtgaaggtc       60

tcctgcaagg ttgccggagg aaccttcagc gactacgcca tcagctgggt gcgacaggcc      120

cctggtcaag ggctggagta cttgggaggg atcattcctg cctttaaaag agcaatgtat      180

ccacggaagt ttcaagacag agtcaccatt accgcggacg agtccacgag cactgcctac      240

atggagctga gaggcctgag atctgaagac acggccctgt attattgtgc gagacctgct      300

ggagactttg gcgatttaaa gtggctacga tcgccttttg actactgggg ccagggaacc      360

ctggtcaccg tctcctca                                                    378


<210> 1138
<211> 126
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region

<400> 1138
Glu Val Gln Leu Leu Glu Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Val Ala Gly Gly Thr Phe Ser Asp Tyr 
            20                  25                  30          


Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Tyr Leu 
        35                  40                  45              


Gly Gly Ile Ile Pro Ala Phe Lys Arg Ala Met Tyr Pro Arg Lys Phe 
    50                  55                  60                  


Gln Asp Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Arg Gly Leu Arg Ser Glu Asp Thr Ala Leu Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Pro Ala Gly Asp Phe Gly Asp Leu Lys Trp Leu Arg Ser Pro 
            100                 105                 110         


Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125     


<210> 1139
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H1

<400> 1139
Gly Thr Phe Ser Asp Tyr Ala Ile Ser 
1               5                   


<210> 1140
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H1

<400> 1140
ggaaccttca gcgactacgc catcagc                                           27


<210> 1141
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H2

<400> 1141
Gly Ile Ile Pro Ala Phe Lys Arg Ala Met Tyr Pro Arg Lys Phe Gln 
1               5                   10                  15      


Asp 
    


<210> 1142
<211> 51
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H2

<400> 1142
gggatcattc ctgcctttaa aagagcaatg tatccacgga agtttcaaga c                51


<210> 1143
<211> 19
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H3

<400> 1143
Ala Arg Pro Ala Gly Asp Phe Gly Asp Leu Lys Trp Leu Arg Ser Pro 
1               5                   10                  15      


Phe Asp Tyr 
            


<210> 1144
<211> 57
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H3

<400> 1144
gcgagacctg ctggagactt tggcgattta aagtggctac gatcgccttt tgactac          57


<210> 1145
<211> 327
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region

<400> 1145
gatattgtgc tgactcagtc tccagccacc ctgtctgtgt ctccagggga aagagccacg       60

ctctcctgca gggccagtga gggtgtaggc atcaacttag cctggtacca gcagaaacct      120

ggccaggctc ccaggctcct catctatggt gcatcgacca gggccactga tatcccagcc      180

aggttcagtg gcagtgggtc tgggacagac ttcactctca ccatcagcag cctgcaatct      240

gaagattttg cagtttatta ttgtcagcag tataatgatt ggcctcccca gctcactttc      300

ggccctggga ccaaagtgga tatcaaa                                          327


<210> 1146
<211> 109
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region

<400> 1146
Asp Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Val Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Glu Gly Val Gly Ile Asn 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 
        35                  40                  45              


Tyr Gly Ala Ser Thr Arg Ala Thr Asp Ile Pro Ala Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Ser 
65                  70                  75                  80  


Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Asn Asp Trp Pro Pro 
                85                  90                  95      


Gln Leu Thr Phe Gly Pro Gly Thr Lys Val Asp Ile Lys 
            100                 105                 


<210> 1147
<211> 11
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region CDR L1

<400> 1147
Arg Ala Ser Glu Gly Val Gly Ile Asn Leu Ala 
1               5                   10      


<210> 1148
<211> 33
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region CDR L1

<400> 1148
agggccagtg agggtgtagg catcaactta gcc                                    33


<210> 1149
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region CDR L2

<400> 1149
Gly Ala Ser Thr Arg Ala Thr 
1               5           


<210> 1150
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region CDR L2

<400> 1150
ggtgcatcga ccagggccac t                                                 21


<210> 1151
<211> 11
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region CDR L3

<400> 1151
Gln Gln Tyr Asn Asp Trp Pro Pro Gln Leu Thr 
1               5                   10      


<210> 1152
<211> 33
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region CDR L3

<400> 1152
cagcagtata atgattggcc tccccagctc act                                    33


<210> 1153
<211> 378
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region

<400> 1153
gaggtgcagc tggtggagtc tggggctgag gtgaagaagc ctgggtcctc ggtgaaggtc       60

tcctgtaagg ttgtcggagg cagtttcagc aactatggta tcagctgggt gcgacaggcc      120

cctggacagg ggcctgagtg gatgggcggg atcatccctg cctttaagac agcaaaatat      180

gcaaagaagt tcgaggacag agtcacaatt accgcggacg aatccacgag cactgcctac      240

atggaggtga gcggcctgag atctgacgac acggccctgt attattgtgc gaggcctgaa      300

cgagactttg ggcatttaaa gtggctacgc tcgccttttg actactgggg ccagggaacc      360

ctggtcaccg tctcctca                                                    378


<210> 1154
<211> 126
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region

<400> 1154
Glu Val Gln Leu Val Glu Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Val Val Gly Gly Ser Phe Ser Asn Tyr 
            20                  25                  30          


Gly Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Pro Glu Trp Met 
        35                  40                  45              


Gly Gly Ile Ile Pro Ala Phe Lys Thr Ala Lys Tyr Ala Lys Lys Phe 
    50                  55                  60                  


Glu Asp Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Val Ser Gly Leu Arg Ser Asp Asp Thr Ala Leu Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Pro Glu Arg Asp Phe Gly His Leu Lys Trp Leu Arg Ser Pro 
            100                 105                 110         


Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125     


<210> 1155
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H1

<400> 1155
Gly Ser Phe Ser Asn Tyr Gly Ile Ser 
1               5                   


<210> 1156
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H1

<400> 1156
ggcagtttca gcaactatgg tatcagc                                           27


<210> 1157
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H2

<400> 1157
Gly Ile Ile Pro Ala Phe Lys Thr Ala Lys Tyr Ala Lys Lys Phe Glu 
1               5                   10                  15      


Asp 
    


<210> 1158
<211> 51
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H2

<400> 1158
gggatcatcc ctgcctttaa gacagcaaaa tatgcaaaga agttcgagga c                51


<210> 1159
<211> 19
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H3

<400> 1159
Ala Arg Pro Glu Arg Asp Phe Gly His Leu Lys Trp Leu Arg Ser Pro 
1               5                   10                  15      


Phe Asp Tyr 
            


<210> 1160
<211> 57
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H3

<400> 1160
gcgaggcctg aacgagactt tgggcattta aagtggctac gctcgccttt tgactac          57


<210> 1161
<211> 327
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region

<400> 1161
gaaacgacac tcacgcagtc tccagccacc ctgtctgtgt ctccagggga aagagtcacc       60

ctctcctgca gggccagtca gggtgttagc atcaacttag cctggtacca gcagaaacct      120

ggccaggctc ccaggctcct catctatggt gcatccacca gggccactga tatcccagcc      180

aggttcagtg gcagtgggtc tgggacagac ttcactctca ccatcagcag cctgcagtct      240

gaagattttg cagtttatta ttgtcagcag tataatgact ggcctcccca gctcactttc      300

ggccctggga ccaaggtgga aatcaaa                                          327


<210> 1162
<211> 109
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region

<400> 1162
Glu Thr Thr Leu Thr Gln Ser Pro Ala Thr Leu Ser Val Ser Pro Gly 
1               5                   10                  15      


Glu Arg Val Thr Leu Ser Cys Arg Ala Ser Gln Gly Val Ser Ile Asn 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 
        35                  40                  45              


Tyr Gly Ala Ser Thr Arg Ala Thr Asp Ile Pro Ala Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Ser 
65                  70                  75                  80  


Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Asn Asp Trp Pro Pro 
                85                  90                  95      


Gln Leu Thr Phe Gly Pro Gly Thr Lys Val Glu Ile Lys 
            100                 105                 


<210> 1163
<211> 11
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region CDR L1

<400> 1163
Arg Ala Ser Gln Gly Val Ser Ile Asn Leu Ala 
1               5                   10      


<210> 1164
<211> 33
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region CDR L1

<400> 1164
agggccagtc agggtgttag catcaactta gcc                                    33


<210> 1165
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region CDR L2

<400> 1165
Gly Ala Ser Thr Arg Ala Thr 
1               5           


<210> 1166
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region CDR L2

<400> 1166
ggtgcatcca ccagggccac t                                                 21


<210> 1167
<211> 11
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region CDR L3

<400> 1167
Gln Gln Tyr Asn Asp Trp Pro Pro Gln Leu Thr 
1               5                   10      


<210> 1168
<211> 33
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region CDR L3

<400> 1168
cagcagtata atgactggcc tccccagctc act                                    33


<210> 1169
<211> 384
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region

<400> 1169
caggtccagc tggtgcagtc tgggtctgag gtgaagaggc ctgggtcatc ggtgaaggtc       60

tcctgcaagg cctcaggagt cgctttgacc accgttgctg tcaactgggt gcgccaggtc      120

cctgggcaag ggcctgagtg gattggaggg atcctcattg ggtttggtaa ggtcagacag      180

gcccagaaat ttgagaaccg agtcactttt accgcggacg catctaggaa cacagcctac      240

atggagttga gcggactgag atctgaggac acggccgtct attactgtgc gataatcgac      300

ccccaagatt gtactcgtgc cagttgcttt tgggtcaact ggctcgcccc ctggggccac      360

ggaaccctgg tcaccgtctc ctca                                             384


<210> 1170
<211> 128
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region

<400> 1170
Gln Val Gln Leu Val Gln Ser Gly Ser Glu Val Lys Arg Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Val Ala Leu Thr Thr Val 
            20                  25                  30          


Ala Val Asn Trp Val Arg Gln Val Pro Gly Gln Gly Pro Glu Trp Ile 
        35                  40                  45              


Gly Gly Ile Leu Ile Gly Phe Gly Lys Val Arg Gln Ala Gln Lys Phe 
    50                  55                  60                  


Glu Asn Arg Val Thr Phe Thr Ala Asp Ala Ser Arg Asn Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Gly Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ile Ile Asp Pro Gln Asp Cys Thr Arg Ala Ser Cys Phe Trp Val 
            100                 105                 110         


Asn Trp Leu Ala Pro Trp Gly His Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125             


<210> 1171
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H1

<400> 1171
Val Ala Leu Thr Thr Val Ala Val Asn 
1               5                   


<210> 1172
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H1

<400> 1172
gtcgctttga ccaccgttgc tgtcaac                                           27


<210> 1173
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H2

<400> 1173
Gly Ile Leu Ile Gly Phe Gly Lys Val Arg Gln Ala Gln Lys Phe Glu 
1               5                   10                  15      


Asn 
    


<210> 1174
<211> 51
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H2

<400> 1174
gggatcctca ttgggtttgg taaggtcaga caggcccaga aatttgagaa c                51


<210> 1175
<211> 21
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H3

<400> 1175
Ala Ile Ile Asp Pro Gln Asp Cys Thr Arg Ala Ser Cys Phe Trp Val 
1               5                   10                  15      


Asn Trp Leu Ala Pro 
            20      


<210> 1176
<211> 63
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H3

<400> 1176
gcgataatcg acccccaaga ttgtactcgt gccagttgct tttgggtcaa ctggctcgcc       60

ccc                                                                     63


<210> 1177
<211> 324
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region

<400> 1177
gacatccggg tgacccagtc tccaggcacc ctgaccttgt ccccagggga gagagcctcc       60

ctctcctgca gggccagtga gagtattctt aacgggaact tagcctggta ccaacagaaa      120

cctggccagg ctcccaggct cctcatctat gctgcttcca gtagggccac tgacatccca      180

gacaggttca gtggcagtgg gtctgggaca gacttcactc tcaccatcag cagactggag      240

cctcaagatt ttgcagtcta ttattgtcag cagtatggtt cggctccgat caccttcggc      300

caagggacac gactggagat taaa                                             324


<210> 1178
<211> 108
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region

<400> 1178
Asp Ile Arg Val Thr Gln Ser Pro Gly Thr Leu Thr Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Ser Leu Ser Cys Arg Ala Ser Glu Ser Ile Leu Asn Gly 
            20                  25                  30          


Asn Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu 
        35                  40                  45              


Ile Tyr Ala Ala Ser Ser Arg Ala Thr Asp Ile Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu 
65                  70                  75                  80  


Pro Gln Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Gly Ser Ala Pro 
                85                  90                  95      


Ile Thr Phe Gly Gln Gly Thr Arg Leu Glu Ile Lys 
            100                 105             


<210> 1179
<211> 12
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region CDR L1

<400> 1179
Arg Ala Ser Glu Ser Ile Leu Asn Gly Asn Leu Ala 
1               5                   10          


<210> 1180
<211> 36
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region CDR L1

<400> 1180
agggccagtg agagtattct taacgggaac ttagcc                                 36


<210> 1181
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region CDR L2

<400> 1181
Ala Ala Ser Ser Arg Ala Thr 
1               5           


<210> 1182
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region CDR L2

<400> 1182
gctgcttcca gtagggccac t                                                 21


<210> 1183
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region CDR L3

<400> 1183
Gln Gln Tyr Gly Ser Ala Pro Ile Thr 
1               5                   


<210> 1184
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region CDR L3

<400> 1184
cagcagtatg gttcggctcc gatcacc                                           27


<210> 1185
<211> 357
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region

<400> 1185
caggtccagc ttgtacagtc tggaagtgag gtgaagaagc ctggggcctc ggtgacggtc       60

tcctgcaagg cctcaggtta caggttttcc aactatggtg tcagctgggt gcgacaggcc      120

cctggacaag gcctagagtg gatgggatgg atcagcgctt acaatggaaa cacaaagtat      180

ggaaatagtc tccagggcag agtcaccctg accacagaca cgaccacggc ctacatggag      240

gtgaggagcc tgacatctga cgacacggcc gtgtattact gtgcgagaga tgtcccaggt      300

gacggggtcc acttcatgga cgtctggggc aaagggacca cggtcaccgt ctcctca         357


<210> 1186
<211> 119
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region

<400> 1186
Gln Val Gln Leu Val Gln Ser Gly Ser Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Thr Val Ser Cys Lys Ala Ser Gly Tyr Arg Phe Ser Asn Tyr 
            20                  25                  30          


Gly Val Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Ser Ala Tyr Asn Gly Asn Thr Lys Tyr Gly Asn Ser Leu 
    50                  55                  60                  


Gln Gly Arg Val Thr Leu Thr Thr Asp Thr Thr Thr Ala Tyr Met Glu 
65                  70                  75                  80  


Val Arg Ser Leu Thr Ser Asp Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
                85                  90                  95      


Asp Val Pro Gly Asp Gly Val His Phe Met Asp Val Trp Gly Lys Gly 
            100                 105                 110         


Thr Thr Val Thr Val Ser Ser 
        115                 


<210> 1187
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H1

<400> 1187
Tyr Arg Phe Ser Asn Tyr Gly Val Ser 
1               5                   


<210> 1188
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H1

<400> 1188
tacaggtttt ccaactatgg tgtcagc                                           27


<210> 1189
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H2

<400> 1189
Trp Ile Ser Ala Tyr Asn Gly Asn Thr Lys Tyr Gly Asn Ser Leu Gln 
1               5                   10                  15      


Gly 
    


<210> 1190
<211> 51
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H2

<400> 1190
tggatcagcg cttacaatgg aaacacaaag tatggaaata gtctccaggg c                51


<210> 1191
<211> 14
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H3

<400> 1191
Ala Arg Asp Val Pro Gly Asp Gly Val His Phe Met Asp Val 
1               5                   10                  


<210> 1192
<211> 42
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H3

<400> 1192
gcgagagatg tcccaggtga cggggtccac ttcatggacg tc                          42


<210> 1193
<211> 336
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region

<400> 1193
gaaattgtga tgacgcagtc tccactctcc ctgcccgtca cccttggaca gtcggcctcc       60

atctcctgca ggtcgagtca aagcctcgta cacagtgata ctaacaccta cttgacctgg      120

tttcagcaga ggccaggcca atctccacgg cgcctcattt ataaggtttc tcaccgggac      180

tctggggtcc cagacagatt cagcggcagt gggtcaggca ctacttttac actgaaaatc      240

agcagggtgg aggctgagga tgttggaatt tattactgca tggagggttc acactgggct      300

ccgactttcg gccaggggac caaggtggaa atcaaa                                336


<210> 1194
<211> 112
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region

<400> 1194
Glu Ile Val Met Thr Gln Ser Pro Leu Ser Leu Pro Val Thr Leu Gly 
1               5                   10                  15      


Gln Ser Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Val His Ser 
            20                  25                  30          


Asp Thr Asn Thr Tyr Leu Thr Trp Phe Gln Gln Arg Pro Gly Gln Ser 
        35                  40                  45              


Pro Arg Arg Leu Ile Tyr Lys Val Ser His Arg Asp Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Thr Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Val Gly Ile Tyr Tyr Cys Met Glu Gly 
                85                  90                  95      


Ser His Trp Ala Pro Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105                 110         


<210> 1195
<211> 16
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region CDR L1

<400> 1195
Arg Ser Ser Gln Ser Leu Val His Ser Asp Thr Asn Thr Tyr Leu Thr 
1               5                   10                  15      


<210> 1196
<211> 48
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region CDR L1

<400> 1196
aggtcgagtc aaagcctcgt acacagtgat actaacacct acttgacc                    48


<210> 1197
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region CDR L2

<400> 1197
Lys Val Ser His Arg Asp Ser 
1               5           


<210> 1198
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region CDR L2

<400> 1198
aaggtttctc accgggactc t                                                 21


<210> 1199
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region CDR L3

<400> 1199
Met Glu Gly Ser His Trp Ala Pro Thr 
1               5                   


<210> 1200
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region CDR L3

<400> 1200
atggagggtt cacactgggc tccgact                                           27


<210> 1201
<211> 354
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region

<400> 1201
caggtccagc ttgtgcagtc tgggggaggc gttgtccagc ctgggagctc cctgagactc       60

tcctgttcag cgtctggatt taccttcatg acctatggca tgcactgggc ccgccaggct      120

ccaggcaagg ggctggagtg ggtcgcagat atttcctttg atgcaaataa gaaatactat      180

agagattccg tgaagggccg attcaccatc tccagggaca attccaagaa cacggtgtat      240

ctgcaaatga acagcctgag acccgaggac acggctgtct acttctgtgc gagaaatacg      300

atttttggag tagttgacta ctggggccag ggaaccctgg tcaccgtctc ctca            354


<210> 1202
<211> 118
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region

<400> 1202
Gln Val Gln Leu Val Gln Ser Gly Gly Gly Val Val Gln Pro Gly Ser 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ser Ala Ser Gly Phe Thr Phe Met Thr Tyr 
            20                  25                  30          


Gly Met His Trp Ala Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Asp Ile Ser Phe Asp Ala Asn Lys Lys Tyr Tyr Arg Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr Phe Cys 
                85                  90                  95      


Ala Arg Asn Thr Ile Phe Gly Val Val Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser 
        115             


<210> 1203
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H1

<400> 1203
Phe Thr Phe Met Thr Tyr Gly Met His 
1               5                   


<210> 1204
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H1

<400> 1204
tttaccttca tgacctatgg catgcac                                           27


<210> 1205
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H2

<400> 1205
Asp Ile Ser Phe Asp Ala Asn Lys Lys Tyr Tyr Arg Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210> 1206
<211> 51
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H2

<400> 1206
gatatttcct ttgatgcaaa taagaaatac tatagagatt ccgtgaaggg c                51


<210> 1207
<211> 11
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H3

<400> 1207
Ala Arg Asn Thr Ile Phe Gly Val Val Asp Tyr 
1               5                   10      


<210> 1208
<211> 33
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H3

<400> 1208
gcgagaaata cgatttttgg agtagttgac tac                                    33


<210> 1209
<211> 324
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region

<400> 1209
gaaattgtat tgacacagtc tccagccacc ctgtctgtgt ctccagggga aagagccacc       60

ctctcctgca gggccagtca gagtgttagc gccaacttag cctggtacca gcataaacct      120

ggccaggctc ccaggctcct catctatggt gcgtccacca gggccagtga tatcccagcc      180

aggttcagtg gcagtgggtc tgggacagag ttcactctca ccatcagcag cctgcagtct      240

gaagattctg cagtttatta ctgtcagcag tataataact ggcctccgtg gacgttcggc      300

caagggacca aggtggaaat caaa                                             324


<210> 1210
<211> 108
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region

<400> 1210
Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Val Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ala Asn 
            20                  25                  30          


Leu Ala Trp Tyr Gln His Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 
        35                  40                  45              


Tyr Gly Ala Ser Thr Arg Ala Ser Asp Ile Pro Ala Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Ser 
65                  70                  75                  80  


Glu Asp Ser Ala Val Tyr Tyr Cys Gln Gln Tyr Asn Asn Trp Pro Pro 
                85                  90                  95      


Trp Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105             


<210> 1211
<211> 11
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region CDR L1

<400> 1211
Arg Ala Ser Gln Ser Val Ser Ala Asn Leu Ala 
1               5                   10      


<210> 1212
<211> 33
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region CDR L1

<400> 1212
agggccagtc agagtgttag cgccaactta gcc                                    33


<210> 1213
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region CDR L2

<400> 1213
Gly Ala Ser Thr Arg Ala Ser 
1               5           


<210> 1214
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region CDR L2

<400> 1214
ggtgcgtcca ccagggccag t                                                 21


<210> 1215
<211> 10
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region CDR L3

<400> 1215
Gln Gln Tyr Asn Asn Trp Pro Pro Trp Thr 
1               5                   10  


<210> 1216
<211> 30
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region CDR L3

<400> 1216
cagcagtata ataactggcc tccgtggacg                                        30


<210> 1217
<211> 366
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region

<400> 1217
caggtccagc tggtgcagtc tggagttgag gtgaagaagc ctggggcctc agtgaaggtc       60

tcctgcaaga cttctggtta cacctttagt aattatggtg tcacctgggt gcgacaggcc      120

cctggacaag ggcttgagta catgggatgg atcagcgctt acaatggtaa cacaaactat      180

gcccagaatg tccagggtcg actcaccatg accacagaca catccacgag cacaggctac      240

atggagttga ggaggctgac atctgacgac acggccgtgt atttctgtgc gagagataaa      300

ggtgtaacag tggccggttc attgcttgac tactggggcc agggaaccct ggtcaccgtc      360

tcctca                                                                 366


<210> 1218
<211> 122
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region

<400> 1218
Gln Val Gln Leu Val Gln Ser Gly Val Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Thr Ser Gly Tyr Thr Phe Ser Asn Tyr 
            20                  25                  30          


Gly Val Thr Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Tyr Met 
        35                  40                  45              


Gly Trp Ile Ser Ala Tyr Asn Gly Asn Thr Asn Tyr Ala Gln Asn Val 
    50                  55                  60                  


Gln Gly Arg Leu Thr Met Thr Thr Asp Thr Ser Thr Ser Thr Gly Tyr 
65                  70                  75                  80  


Met Glu Leu Arg Arg Leu Thr Ser Asp Asp Thr Ala Val Tyr Phe Cys 
                85                  90                  95      


Ala Arg Asp Lys Gly Val Thr Val Ala Gly Ser Leu Leu Asp Tyr Trp 
            100                 105                 110         


Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120         


<210> 1219
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H1

<400> 1219
Tyr Thr Phe Ser Asn Tyr Gly Val Thr 
1               5                   


<210> 1220
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H1

<400> 1220
tacaccttta gtaattatgg tgtcacc                                           27


<210> 1221
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H2

<400> 1221
Trp Ile Ser Ala Tyr Asn Gly Asn Thr Asn Tyr Ala Gln Asn Val Gln 
1               5                   10                  15      


Gly 
    


<210> 1222
<211> 51
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H2

<400> 1222
tggatcagcg cttacaatgg taacacaaac tatgcccaga atgtccaggg t                51


<210> 1223
<211> 15
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H3

<400> 1223
Ala Arg Asp Lys Gly Val Thr Val Ala Gly Ser Leu Leu Asp Tyr 
1               5                   10                  15  


<210> 1224
<211> 45
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H3

<400> 1224
gcgagagata aaggtgtaac agtggccggt tcattgcttg actac                       45


<210> 1225
<211> 339
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region

<400> 1225
gaaattgtga tgacacagtc tccactctcc ctgcccgtca cccttggaca gccggcctcc       60

atctcctgca ggtctagtca aagtctcgaa catagtgatg gaaacaccta cttgaattgg      120

tttcagcaga ggccaggcca atctccaagg cgcctcattt ataaggtttc taaccgggac      180

tctggggtcc cagacagatt cagcggcagt gggtcaggca ctgatttcac actgaaaatc      240

aacagggtgg aggctgagga tgttggggtt tattactgca tggaaagtac acactggcct      300

ccgtacactt ttggccaggg gaccaaggtg gagatcaaa                             339


<210> 1226
<211> 113
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region

<400> 1226
Glu Ile Val Met Thr Gln Ser Pro Leu Ser Leu Pro Val Thr Leu Gly 
1               5                   10                  15      


Gln Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Glu His Ser 
            20                  25                  30          


Asp Gly Asn Thr Tyr Leu Asn Trp Phe Gln Gln Arg Pro Gly Gln Ser 
        35                  40                  45              


Pro Arg Arg Leu Ile Tyr Lys Val Ser Asn Arg Asp Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Asn Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Met Glu Ser 
                85                  90                  95      


Thr His Trp Pro Pro Tyr Thr Phe Gly Gln Gly Thr Lys Val Glu Ile 
            100                 105                 110         


Lys 
    


<210> 1227
<211> 16
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region CDR L1

<400> 1227
Arg Ser Ser Gln Ser Leu Glu His Ser Asp Gly Asn Thr Tyr Leu Asn 
1               5                   10                  15      


<210> 1228
<211> 48
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region CDR L1

<400> 1228
aggtctagtc aaagtctcga acatagtgat ggaaacacct acttgaat                    48


<210> 1229
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region CDR L2

<400> 1229
Lys Val Ser Asn Arg Asp Ser 
1               5           


<210> 1230
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region CDR L2

<400> 1230
aaggtttcta accgggactc t                                                 21


<210> 1231
<211> 10
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region CDR L3

<400> 1231
Met Glu Ser Thr His Trp Pro Pro Tyr Thr 
1               5                   10  


<210> 1232
<211> 30
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region CDR L3

<400> 1232
atggaaagta cacactggcc tccgtacact                                        30


<210> 1233
<211> 360
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region

<400> 1233
caggtccagc tggtgcagtc tggacctgag gtgaagaagc ctggggcctc agtgcgggtc       60

tcctgcaaga cttctggttt caccttgtcc cattatggtg tcagttggct gcggcaggcc      120

cctggacacg gacttgagtg gctgggctgg atcagcgctt acaactataa cacacaattt      180

ggacacagaa tggagggcag gctcaccatg accacagaca cttccacagc ctatatggac      240

ctgacgagcc tgacttctga cgacacggcc atatattact gtgcgagaga ttccccttca      300

gacacagcgg cagcactcct tgacttctgg ggccagggaa ccctggtcac cgtctcctca      360


<210> 1234
<211> 120
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region

<400> 1234
Gln Val Gln Leu Val Gln Ser Gly Pro Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Arg Val Ser Cys Lys Thr Ser Gly Phe Thr Leu Ser His Tyr 
            20                  25                  30          


Gly Val Ser Trp Leu Arg Gln Ala Pro Gly His Gly Leu Glu Trp Leu 
        35                  40                  45              


Gly Trp Ile Ser Ala Tyr Asn Tyr Asn Thr Gln Phe Gly His Arg Met 
    50                  55                  60                  


Glu Gly Arg Leu Thr Met Thr Thr Asp Thr Ser Thr Ala Tyr Met Asp 
65                  70                  75                  80  


Leu Thr Ser Leu Thr Ser Asp Asp Thr Ala Ile Tyr Tyr Cys Ala Arg 
                85                  90                  95      


Asp Ser Pro Ser Asp Thr Ala Ala Ala Leu Leu Asp Phe Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser 
        115                 120 


<210> 1235
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H1

<400> 1235
Phe Thr Leu Ser His Tyr Gly Val Ser 
1               5                   


<210> 1236
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H1

<400> 1236
ttcaccttgt cccattatgg tgtcagt                                           27


<210> 1237
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H2

<400> 1237
Trp Ile Ser Ala Tyr Asn Tyr Asn Thr Gln Phe Gly His Arg Met Glu 
1               5                   10                  15      


Gly 
    


<210> 1238
<211> 51
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H2

<400> 1238
tggatcagcg cttacaacta taacacacaa tttggacaca gaatggaggg c                51


<210> 1239
<211> 15
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H3

<400> 1239
Ala Arg Asp Ser Pro Ser Asp Thr Ala Ala Ala Leu Leu Asp Phe 
1               5                   10                  15  


<210> 1240
<211> 45
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H3

<400> 1240
gcgagagatt ccccttcaga cacagcggca gcactccttg acttc                       45


<210> 1241
<211> 339
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region

<400> 1241
gatattgtgc tgactcagtc tcccctctcc ctgcccgtca ctcttggaca gccggcctcc       60

atctcctgca ggtctagtca aagcctcgta tacagtgatg gcaacaccta cttgagttgg      120

tttcagcaga ggccaggcca agctccaagg cgcctaattt ataagatttc taaccgagac      180

tctggggtcc cagacagatt cagcggcagt gggtcaggca ctgatttcac actaaagatc      240

agcagggtgg aggctgagga tgttgggatt tattactgca tgcaagctac acactggcct      300

cgtctcagtt tcggcggagg gaccaaggtg gagatcaaa                             339


<210> 1242
<211> 113
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region

<400> 1242
Asp Ile Val Leu Thr Gln Ser Pro Leu Ser Leu Pro Val Thr Leu Gly 
1               5                   10                  15      


Gln Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Val Tyr Ser 
            20                  25                  30          


Asp Gly Asn Thr Tyr Leu Ser Trp Phe Gln Gln Arg Pro Gly Gln Ala 
        35                  40                  45              


Pro Arg Arg Leu Ile Tyr Lys Ile Ser Asn Arg Asp Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Val Gly Ile Tyr Tyr Cys Met Gln Ala 
                85                  90                  95      


Thr His Trp Pro Arg Leu Ser Phe Gly Gly Gly Thr Lys Val Glu Ile 
            100                 105                 110         


Lys 
    


<210> 1243
<211> 16
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region CDR L1

<400> 1243
Arg Ser Ser Gln Ser Leu Val Tyr Ser Asp Gly Asn Thr Tyr Leu Ser 
1               5                   10                  15      


<210> 1244
<211> 48
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region CDR L1

<400> 1244
aggtctagtc aaagcctcgt atacagtgat ggcaacacct acttgagt                    48


<210> 1245
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region CDR L2

<400> 1245
Lys Ile Ser Asn Arg Asp Ser 
1               5           


<210> 1246
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region CDR L2

<400> 1246
aagatttcta accgagactc t                                                 21


<210> 1247
<211> 10
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region CDR L3

<400> 1247
Met Gln Ala Thr His Trp Pro Arg Leu Ser 
1               5                   10  


<210> 1248
<211> 30
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region CDR L3

<400> 1248
atgcaagcta cacactggcc tcgtctcagt                                        30


<210> 1249
<211> 354
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region

<400> 1249
gaggtgcagc tggtggagtc tggggctgaa atgaagcagc ctggggcctc agtgaaagtc       60

tcctgcgagg gttttggaaa cactctcagt gaaagatcca tacactgggt gcgacaggct      120

ccaggaaaag ggcctgagtg gatgggagat tatgatcatg aagataaaga agcaatctac      180

gcaccgaagt tccagggcag actcacaata agcgcggaca tgtctacaga catagcctcc      240

ttggagctga acagcctgac atcagaagac acagccgtct attattgtgc gacagtgatc      300

gctgtggggg cttatgacat ctggggccag ggaaccctgg tcaccgtctc ctca            354


<210> 1250
<211> 118
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region

<400> 1250
Glu Val Gln Leu Val Glu Ser Gly Ala Glu Met Lys Gln Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Glu Gly Phe Gly Asn Thr Leu Ser Glu Arg 
            20                  25                  30          


Ser Ile His Trp Val Arg Gln Ala Pro Gly Lys Gly Pro Glu Trp Met 
        35                  40                  45              


Gly Asp Tyr Asp His Glu Asp Lys Glu Ala Ile Tyr Ala Pro Lys Phe 
    50                  55                  60                  


Gln Gly Arg Leu Thr Ile Ser Ala Asp Met Ser Thr Asp Ile Ala Ser 
65                  70                  75                  80  


Leu Glu Leu Asn Ser Leu Thr Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Thr Val Ile Ala Val Gly Ala Tyr Asp Ile Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser 
        115             


<210> 1251
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H1

<400> 1251
Asn Thr Leu Ser Glu Arg Ser Ile His 
1               5                   


<210> 1252
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H1

<400> 1252
aacactctca gtgaaagatc catacac                                           27


<210> 1253
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H2

<400> 1253
Asp Tyr Asp His Glu Asp Lys Glu Ala Ile Tyr Ala Pro Lys Phe Gln 
1               5                   10                  15      


Gly 
    


<210> 1254
<211> 51
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H2

<400> 1254
gattatgatc atgaagataa agaagcaatc tacgcaccga agttccaggg c                51


<210> 1255
<211> 11
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H3

<400> 1255
Ala Thr Val Ile Ala Val Gly Ala Tyr Asp Ile 
1               5                   10      


<210> 1256
<211> 33
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H3

<400> 1256
gcgacagtga tcgctgtggg ggcttatgac atc                                    33


<210> 1257
<211> 321
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region

<400> 1257
gaaattgtat tgacacagtc tccatcctcc ctgtatgcgt ctatagggga cagagtcacc       60

atcacttgcc ggactggtca gagcatttcc cggtatttga attggtatca gcagaaacct      120

gggaaagccc ctaaactcct gatctatgca gcatccactt tgcaaagtgg ggtcccatca      180

cgtttcagtg gcagtggcgc tgggacagat ttcactctca ccatcagagg tctgctacct      240

gaagattttg caacttactt ctgtcaacag agttacatta tcccctacac ttttggccag      300

gggaccaagg tggaaatcaa a                                                321


<210> 1258
<211> 107
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region

<400> 1258
Glu Ile Val Leu Thr Gln Ser Pro Ser Ser Leu Tyr Ala Ser Ile Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Thr Gly Gln Ser Ile Ser Arg Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Thr Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ala Gly Thr Asp Phe Thr Leu Thr Ile Arg Gly Leu Leu Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Phe Cys Gln Gln Ser Tyr Ile Ile Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210> 1259
<211> 11
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region CDR L1

<400> 1259
Arg Thr Gly Gln Ser Ile Ser Arg Tyr Leu Asn 
1               5                   10      


<210> 1260
<211> 33
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region CDR L1

<400> 1260
cggactggtc agagcatttc ccggtatttg aat                                    33


<210> 1261
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region CDR L2

<400> 1261
Ala Ala Ser Thr Leu Gln Ser 
1               5           


<210> 1262
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region CDR L2

<400> 1262
gcagcatcca ctttgcaaag t                                                 21


<210> 1263
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region CDR L3

<400> 1263
Gln Gln Ser Tyr Ile Ile Pro Tyr Thr 
1               5                   


<210> 1264
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region CDR L3

<400> 1264
caacagagtt acattatccc ctacact                                           27


<210> 1265
<211> 366
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region

<400> 1265
caggtgcagc tacagcagtg gggcgcagga ctggtgaagc cttcggagac cctgtccctc       60

acctgcgctg tgtatggtgg gtccttcagt ggttaccagt ggcactggtt ccgccagccc      120

ccagggaagg gtctggagtg gattggggaa atcaatcata gtgaaatcac ccactacaac      180

gcgtccctca agagtcgagt caccctatct attgacacgt ccaagaacca attctccctg      240

aacctgacct ctgtgaccgc cgcggacacg gctgtttatt actgtgcgag agcctcgagt      300

gggagctata acttcgaata ctggttcgac ccctggggcc agggaaccct ggtcaccgtc      360

tcctca                                                                 366


<210> 1266
<211> 122
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region

<400> 1266
Gln Val Gln Leu Gln Gln Trp Gly Ala Gly Leu Val Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Ala Val Tyr Gly Gly Ser Phe Ser Gly Tyr 
            20                  25                  30          


Gln Trp His Trp Phe Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Glu Ile Asn His Ser Glu Ile Thr His Tyr Asn Ala Ser Leu Lys 
    50                  55                  60                  


Ser Arg Val Thr Leu Ser Ile Asp Thr Ser Lys Asn Gln Phe Ser Leu 
65                  70                  75                  80  


Asn Leu Thr Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Ala Ser Ser Gly Ser Tyr Asn Phe Glu Tyr Trp Phe Asp Pro Trp 
            100                 105                 110         


Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120         


<210> 1267
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H1

<400> 1267
Gly Ser Phe Ser Gly Tyr Gln Trp His 
1               5                   


<210> 1268
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H1

<400> 1268
gggtccttca gtggttacca gtggcac                                           27


<210> 1269
<211> 16
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H2

<400> 1269
Glu Ile Asn His Ser Glu Ile Thr His Tyr Asn Ala Ser Leu Lys Ser 
1               5                   10                  15      


<210> 1270
<211> 48
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H2

<400> 1270
gaaatcaatc atagtgaaat cacccactac aacgcgtccc tcaagagt                    48


<210> 1271
<211> 16
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H3

<400> 1271
Ala Arg Ala Ser Ser Gly Ser Tyr Asn Phe Glu Tyr Trp Phe Asp Pro 
1               5                   10                  15      


<210> 1272
<211> 48
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H3

<400> 1272
gcgagagcct cgagtgggag ctataacttc gaatactggt tcgacccc                    48


<210> 1273
<211> 324
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region

<400> 1273
cagtctgtgc tgacgcagcc gccctcggtg tccgtggccc caggaaagac ggcctggctt       60

acctgtgggg gaaacaacat tggcagtaag agagtgcact ggtaccggca gaagccaggc      120

caggcccctg tgctggtcgt ttatgatgat tacgaccggc cctcagggac ccctgagcga      180

gtctctggct ccaactctgg gaacacggcc accctgacca tcagcagggt cgaagacggg      240

gatgagggcg actattattg tcaggtgtgg gatgatccca gtgatcatgc ggtgttcggc      300

ggcgggacca agctgaccgt ccta                                             324


<210> 1274
<211> 108
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region

<400> 1274
Gln Ser Val Leu Thr Gln Pro Pro Ser Val Ser Val Ala Pro Gly Lys 
1               5                   10                  15      


Thr Ala Trp Leu Thr Cys Gly Gly Asn Asn Ile Gly Ser Lys Arg Val 
            20                  25                  30          


His Trp Tyr Arg Gln Lys Pro Gly Gln Ala Pro Val Leu Val Val Tyr 
        35                  40                  45              


Asp Asp Tyr Asp Arg Pro Ser Gly Thr Pro Glu Arg Val Ser Gly Ser 
    50                  55                  60                  


Asn Ser Gly Asn Thr Ala Thr Leu Thr Ile Ser Arg Val Glu Asp Gly 
65                  70                  75                  80  


Asp Glu Gly Asp Tyr Tyr Cys Gln Val Trp Asp Asp Pro Ser Asp His 
                85                  90                  95      


Ala Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105             


<210> 1275
<211> 11
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region CDR L1

<400> 1275
Gly Gly Asn Asn Ile Gly Ser Lys Arg Val His 
1               5                   10      


<210> 1276
<211> 33
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region CDR L1

<400> 1276
gggggaaaca acattggcag taagagagtg cac                                    33


<210> 1277
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region CDR L2

<400> 1277
Asp Asp Tyr Asp Arg Pro Ser 
1               5           


<210> 1278
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region CDR L2

<400> 1278
gatgattacg accggccctc a                                                 21


<210> 1279
<211> 11
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region CDR L3

<400> 1279
Gln Val Trp Asp Asp Pro Ser Asp His Ala Val 
1               5                   10      


<210> 1280
<211> 33
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region CDR L3

<400> 1280
caggtgtggg atgatcccag tgatcatgcg gtg                                    33


<210> 1281
<211> 366
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region

<400> 1281
caggtccagc ttgtgcagtc tggaactgag gttaagaagc ctggggcctc agtgaaggtc       60

tcctgcttga cttctggcta cacctttaca cactttggta tcagctgggt gcgacaggcc      120

ccaggacaag ggcttgagtg gatgggatgg ttcagcgctt acaatggtaa cacaaagtat      180

gcacagaagt tccagggcag aatcaccctc accatagaca catccacgag catcgcctac      240

ttggaactga ggagcctgag atctgacgac acggccgtat attattgtgc gagagacccc      300

ccgagtctga cagcagctgg tactctggac tactggggcc agggaaccct ggtcaccgtc      360

tcctca                                                                 366


<210> 1282
<211> 122
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region

<400> 1282
Gln Val Gln Leu Val Gln Ser Gly Thr Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Leu Thr Ser Gly Tyr Thr Phe Thr His Phe 
            20                  25                  30          


Gly Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Phe Ser Ala Tyr Asn Gly Asn Thr Lys Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Ile Thr Leu Thr Ile Asp Thr Ser Thr Ser Ile Ala Tyr 
65                  70                  75                  80  


Leu Glu Leu Arg Ser Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Pro Pro Ser Leu Thr Ala Ala Gly Thr Leu Asp Tyr Trp 
            100                 105                 110         


Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120         


<210> 1283
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H1

<400> 1283
Tyr Thr Phe Thr His Phe Gly Ile Ser 
1               5                   


<210> 1284
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H1

<400> 1284
tacaccttta cacactttgg tatcagc                                           27


<210> 1285
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H2

<400> 1285
Trp Phe Ser Ala Tyr Asn Gly Asn Thr Lys Tyr Ala Gln Lys Phe Gln 
1               5                   10                  15      


Gly 
    


<210> 1286
<211> 51
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H2

<400> 1286
tggttcagcg cttacaatgg taacacaaag tatgcacaga agttccaggg c                51


<210> 1287
<211> 15
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H3

<400> 1287
Ala Arg Asp Pro Pro Ser Leu Thr Ala Ala Gly Thr Leu Asp Tyr 
1               5                   10                  15  


<210> 1288
<211> 45
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H3

<400> 1288
gcgagagacc ccccgagtct gacagcagct ggtactctgg actac                       45


<210> 1289
<211> 336
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region

<400> 1289
gacatccggt tgacccagtc tccactctcc ctgcccgtca cccttggaca gccggcctcc       60

atctcctgca gctctaatca aagcctcgta tacagtgatg gaaacaccta cttgagttgg      120

tttcagcaga ggccaggcca atctccaagg cgcctaattt ataaggtttc tgatcgggac      180

tctggggtcc cagacagatt cagcggcagt gggtcaggca ctgatttcac actgaaaatc      240

agcagggtgg aggctgagga tgttggggtt tattactgca tgcaagctac agactggccc      300

cggacgttcg gccaagggac caaggtggag atcaaa                                336


<210> 1290
<211> 112
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region

<400> 1290
Asp Ile Arg Leu Thr Gln Ser Pro Leu Ser Leu Pro Val Thr Leu Gly 
1               5                   10                  15      


Gln Pro Ala Ser Ile Ser Cys Ser Ser Asn Gln Ser Leu Val Tyr Ser 
            20                  25                  30          


Asp Gly Asn Thr Tyr Leu Ser Trp Phe Gln Gln Arg Pro Gly Gln Ser 
        35                  40                  45              


Pro Arg Arg Leu Ile Tyr Lys Val Ser Asp Arg Asp Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Met Gln Ala 
                85                  90                  95      


Thr Asp Trp Pro Arg Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105                 110         


<210> 1291
<211> 16
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region CDR L1

<400> 1291
Ser Ser Asn Gln Ser Leu Val Tyr Ser Asp Gly Asn Thr Tyr Leu Ser 
1               5                   10                  15      


<210> 1292
<211> 48
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region CDR L1

<400> 1292
agctctaatc aaagcctcgt atacagtgat ggaaacacct acttgagt                    48


<210> 1293
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region CDR L2

<400> 1293
Lys Val Ser Asp Arg Asp Ser 
1               5           


<210> 1294
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region CDR L2

<400> 1294
aaggtttctg atcgggactc t                                                 21


<210> 1295
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region CDR L3

<400> 1295
Met Gln Ala Thr Asp Trp Pro Arg Thr 
1               5                   


<210> 1296
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region CDR L3

<400> 1296
atgcaagcta cagactggcc ccggacg                                           27


<210> 1297
<211> 357
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region

<400> 1297
gaggtgcagc tggtggagtc tggggctgag gtgaagaagc ctggggactc agtgaaggtc       60

tcctgcaggg cttctggata cagcttcacc ggcccctttt tgcactgggt gcgacaggcc      120

cctggacagc ggcttgagca catgggatgg atcaacccta gaagtggtga aacaaaatat      180

gcacagtcct ttctgggcag ggtcaccatg accagggaca cgtccattcg ctcagccacc      240

ttggaattga gtagcctgag atctgacgac acggccgtgt attattgtgc gagagacctc      300

tatagcagtg gctggctcga caactggggc cagggaaccc tggtcaccgt ctcctca         357


<210> 1298
<211> 119
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region

<400> 1298
Glu Val Gln Leu Val Glu Ser Gly Ala Glu Val Lys Lys Pro Gly Asp 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Arg Ala Ser Gly Tyr Ser Phe Thr Gly Pro 
            20                  25                  30          


Phe Leu His Trp Val Arg Gln Ala Pro Gly Gln Arg Leu Glu His Met 
        35                  40                  45              


Gly Trp Ile Asn Pro Arg Ser Gly Glu Thr Lys Tyr Ala Gln Ser Phe 
    50                  55                  60                  


Leu Gly Arg Val Thr Met Thr Arg Asp Thr Ser Ile Arg Ser Ala Thr 
65                  70                  75                  80  


Leu Glu Leu Ser Ser Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Leu Tyr Ser Ser Gly Trp Leu Asp Asn Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210> 1299
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H1

<400> 1299
Tyr Ser Phe Thr Gly Pro Phe Leu His 
1               5                   


<210> 1300
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H1

<400> 1300
tacagcttca ccggcccctt tttgcac                                           27


<210> 1301
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H2

<400> 1301
Trp Ile Asn Pro Arg Ser Gly Glu Thr Lys Tyr Ala Gln Ser Phe Leu 
1               5                   10                  15      


Gly 
    


<210> 1302
<211> 51
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H2

<400> 1302
tggatcaacc ctagaagtgg tgaaacaaaa tatgcacagt cctttctggg c                51


<210> 1303
<211> 12
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H3

<400> 1303
Ala Arg Asp Leu Tyr Ser Ser Gly Trp Leu Asp Asn 
1               5                   10          


<210> 1304
<211> 36
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H3

<400> 1304
gcgagagacc tctatagcag tggctggctc gacaac                                 36


<210> 1305
<211> 321
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region

<400> 1305
gaaacgacac tcacgcagtc tccagccacc ctgtctgtgt ctccagggga aagggccacc       60

ctctcctgca gggccagtca gggtcttagc agcaacttag cctggtacca gcacaaacct      120

ggccaggctc ccaggctcct cgtctatggt gttgccacca gggccactgg tgtcccagcc      180

aggttcagtg gcagtgggtc tgggacagag ttcactctca ccatcagcag cctgcagtct      240

gacgattttg cactttatta ctgtcatcag tataatgact ggccctacac ttttggccag      300

gggaccaagc tggagatcaa a                                                321


<210> 1306
<211> 107
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region

<400> 1306
Glu Thr Thr Leu Thr Gln Ser Pro Ala Thr Leu Ser Val Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Gly Leu Ser Ser Asn 
            20                  25                  30          


Leu Ala Trp Tyr Gln His Lys Pro Gly Gln Ala Pro Arg Leu Leu Val 
        35                  40                  45              


Tyr Gly Val Ala Thr Arg Ala Thr Gly Val Pro Ala Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Ser 
65                  70                  75                  80  


Asp Asp Phe Ala Leu Tyr Tyr Cys His Gln Tyr Asn Asp Trp Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210> 1307
<211> 11
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region CDR L1

<400> 1307
Arg Ala Ser Gln Gly Leu Ser Ser Asn Leu Ala 
1               5                   10      


<210> 1308
<211> 33
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region CDR L1

<400> 1308
agggccagtc agggtcttag cagcaactta gcc                                    33


<210> 1309
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region CDR L2

<400> 1309
Gly Val Ala Thr Arg Ala Thr 
1               5           


<210> 1310
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region CDR L2

<400> 1310
ggtgttgcca ccagggccac t                                                 21


<210> 1311
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region CDR L3

<400> 1311
His Gln Tyr Asn Asp Trp Pro Tyr Thr 
1               5                   


<210> 1312
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region CDR L3

<400> 1312
catcagtata atgactggcc ctacact                                           27


<210> 1313
<211> 384
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region

<400> 1313
gaggtgcagc tggtggagtc tgggggaggc ttggtaaagc ctggggggtc cctaagactc       60

tcatgtgcag cctctggatt catcttccgc aacgcctgga tgagctgggt ccgccaggct      120

ccagggaagg ggctggagtg ggttggccgg attaaaagga caagtgaagg tgggtcagtc      180

gactacgcga cacccgtgca aggcagattc tccatctcaa gagatgattc tagaaacacg      240

ctgtatctgc aaatgaacag cctggaaacc gacgacacag ccgtgtatta ctgttccaca      300

ggcccaccct actcttactt tgatagtagt ggttattcgg tcgtggacta ctggggccag      360

ggaaccctgg tcaccgtctc ctca                                             384


<210> 1314
<211> 128
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region

<400> 1314
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ile Phe Arg Asn Ala 
            20                  25                  30          


Trp Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Gly Arg Ile Lys Arg Thr Ser Glu Gly Gly Ser Val Asp Tyr Ala Thr 
    50                  55                  60                  


Pro Val Gln Gly Arg Phe Ser Ile Ser Arg Asp Asp Ser Arg Asn Thr 
65                  70                  75                  80  


Leu Tyr Leu Gln Met Asn Ser Leu Glu Thr Asp Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Ser Thr Gly Pro Pro Tyr Ser Tyr Phe Asp Ser Ser Gly Tyr 
            100                 105                 110         


Ser Val Val Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125             


<210> 1315
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H1

<400> 1315
Phe Ile Phe Arg Asn Ala Trp Met Ser 
1               5                   


<210> 1316
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H1

<400> 1316
ttcatcttcc gcaacgcctg gatgagc                                           27


<210> 1317
<211> 19
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H2

<400> 1317
Arg Ile Lys Arg Thr Ser Glu Gly Gly Ser Val Asp Tyr Ala Thr Pro 
1               5                   10                  15      


Val Gln Gly 
            


<210> 1318
<211> 57
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H2

<400> 1318
cggattaaaa ggacaagtga aggtgggtca gtcgactacg cgacacccgt gcaaggc          57


<210> 1319
<211> 19
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H3

<400> 1319
Ser Thr Gly Pro Pro Tyr Ser Tyr Phe Asp Ser Ser Gly Tyr Ser Val 
1               5                   10                  15      


Val Asp Tyr 
            


<210> 1320
<211> 57
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H3

<400> 1320
tccacaggcc caccctactc ttactttgat agtagtggtt attcggtcgt ggactac          57


<210> 1321
<211> 330
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region

<400> 1321
cagtctgtgt tgacgcagcc gccctcagcg tctgggaccc ccgggcagag ggtcaccatc       60

tcttgttctg caagcagctc caacatcgga gataattatt tctactggta ccaacaactc      120

ccaggaaagg cccccacact cctcatgtat ggtagtgatc agcggtcctc aggggtccct      180

gaccgattct ctggctccca gtctggcacc tctgcctccc tggccatcag tgggctccgg      240

tccgaggatg aagctgatta ttattgtgca gcttgggatg acagcctgag tggtccggtg      300

ttcggcggag ggaccaagct gaccgtccta                                       330


<210> 1322
<211> 110
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region

<400> 1322
Gln Ser Val Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln 
1               5                   10                  15      


Arg Val Thr Ile Ser Cys Ser Ala Ser Ser Ser Asn Ile Gly Asp Asn 
            20                  25                  30          


Tyr Phe Tyr Trp Tyr Gln Gln Leu Pro Gly Lys Ala Pro Thr Leu Leu 
        35                  40                  45              


Met Tyr Gly Ser Asp Gln Arg Ser Ser Gly Val Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gln Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Arg 
65                  70                  75                  80  


Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Asp Ser Leu 
                85                  90                  95      


Ser Gly Pro Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 110 


<210> 1323
<211> 13
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region CDR L1

<400> 1323
Ser Ala Ser Ser Ser Asn Ile Gly Asp Asn Tyr Phe Tyr 
1               5                   10              


<210> 1324
<211> 39
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region CDR L1

<400> 1324
tctgcaagca gctccaacat cggagataat tatttctac                              39


<210> 1325
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region CDR L2

<400> 1325
Gly Ser Asp Gln Arg Ser Ser 
1               5           


<210> 1326
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region CDR L2

<400> 1326
ggtagtgatc agcggtcctc a                                                 21


<210> 1327
<211> 11
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region CDR L3

<400> 1327
Ala Ala Trp Asp Asp Ser Leu Ser Gly Pro Val 
1               5                   10      


<210> 1328
<211> 33
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region CDR L3

<400> 1328
gcagcttggg atgacagcct gagtggtccg gtg                                    33


<210> 1329
<211> 366
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region

<400> 1329
gaggtgcagc tggtggagtc tgggggaggc ttggtacagc ctggggggtc cctgagactc       60

tcgtgtgcag cctctggatt ctccttcagt gactacagca tgaactgggt ccgccaggct      120

ccagggaagg ggctggagtg ggtttcatat attactccta gtagtagaaa taaattctat      180

gcagactctg tgaggggccg attcaccatc tccagagaca atgccgagaa ttcactgtat      240

ctgcaaatga acagcctgag agtcgaagac acggctgttt attactgtgt cagaagtttg      300

cattggggcg ccgcgatcga gagatgggac gtctggggcc aagggaccac ggtcaccgtc      360

tcctca                                                                 366


<210> 1330
<211> 122
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region

<400> 1330
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ser Phe Ser Asp Tyr 
            20                  25                  30          


Ser Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Tyr Ile Thr Pro Ser Ser Arg Asn Lys Phe Tyr Ala Asp Ser Val 
    50                  55                  60                  


Arg Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Glu Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Val Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Val Arg Ser Leu His Trp Gly Ala Ala Ile Glu Arg Trp Asp Val Trp 
            100                 105                 110         


Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120         


<210> 1331
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H1

<400> 1331
Phe Ser Phe Ser Asp Tyr Ser Met Asn 
1               5                   


<210> 1332
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H1

<400> 1332
ttctccttca gtgactacag catgaac                                           27


<210> 1333
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H2

<400> 1333
Tyr Ile Thr Pro Ser Ser Arg Asn Lys Phe Tyr Ala Asp Ser Val Arg 
1               5                   10                  15      


Gly 
    


<210> 1334
<211> 51
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H2

<400> 1334
tatattactc ctagtagtag aaataaattc tatgcagact ctgtgagggg c                51


<210> 1335
<211> 15
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H3

<400> 1335
Val Arg Ser Leu His Trp Gly Ala Ala Ile Glu Arg Trp Asp Val 
1               5                   10                  15  


<210> 1336
<211> 45
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H3

<400> 1336
gtcagaagtt tgcattgggg cgccgcgatc gagagatggg acgtc                       45


<210> 1337
<211> 324
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region

<400> 1337
gaaattgtat tgacgcagtc tccaggcacc ctgtcgttgt ctccagggga aagagccacc       60

ctctcctgca gggccagtca gagtattagc agcagcttct ttgcctggta ccagcagaca      120

cctggccagg cccccagact cctcatgtat gctacatcca gcagggccac tggcatccca      180

gacaggttca gtggcagtgg gtctgggaca gacttcactc tcaccatcag cagagtggag      240

cctgaagatt ttgcagtgta ttactgtcag cagtctggca gttcaccgta cacttttggc      300

caggggacca aggtggaaat caaa                                             324


<210> 1338
<211> 108
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region

<400> 1338
Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Ile Ser Ser Ser 
            20                  25                  30          


Phe Phe Ala Trp Tyr Gln Gln Thr Pro Gly Gln Ala Pro Arg Leu Leu 
        35                  40                  45              


Met Tyr Ala Thr Ser Ser Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Val Glu 
65                  70                  75                  80  


Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Ser Gly Ser Ser Pro 
                85                  90                  95      


Tyr Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105             


<210> 1339
<211> 12
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region CDR L1

<400> 1339
Arg Ala Ser Gln Ser Ile Ser Ser Ser Phe Phe Ala 
1               5                   10          


<210> 1340
<211> 36
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region CDR L1

<400> 1340
agggccagtc agagtattag cagcagcttc tttgcc                                 36


<210> 1341
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region CDR L2

<400> 1341
Ala Thr Ser Ser Arg Ala Thr 
1               5           


<210> 1342
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region CDR L2

<400> 1342
gctacatcca gcagggccac t                                                 21


<210> 1343
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region CDR L3

<400> 1343
Gln Gln Ser Gly Ser Ser Pro Tyr Thr 
1               5                   


<210> 1344
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region CDR L3

<400> 1344
cagcagtctg gcagttcacc gtacact                                           27


<210> 1345
<211> 351
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region

<400> 1345
gaggtgcagc tgttggagtc ggggggaggc gtggtccagc ctgggaggtc cctgagactc       60

tcctgtacag cctctggatt caccttcagt gaccatgcta tgtactgggt ccgccaggct      120

ccaggcaaag ggctagagtg ggtggcactt atatcatttg atggaaggaa tatatactac      180

gcagactccg tgaagggccg attcaccatc tccagagaca attccaagaa cacgctgtat      240

ctgcagatga acagcctgag agctgaggac acggctgtct attactgtgc gagagatcaa      300

tggctggttc ctgactactg gggccaggga accctggtca ccgtctcctc a               351


<210> 1346
<211> 117
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region

<400> 1346
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Thr Ala Ser Gly Phe Thr Phe Ser Asp His 
            20                  25                  30          


Ala Met Tyr Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Leu Ile Ser Phe Asp Gly Arg Asn Ile Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Gln Trp Leu Val Pro Asp Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210> 1347
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H1

<400> 1347
Phe Thr Phe Ser Asp His Ala Met Tyr 
1               5                   


<210> 1348
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H1

<400> 1348
ttcaccttca gtgaccatgc tatgtac                                           27


<210> 1349
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H2

<400> 1349
Leu Ile Ser Phe Asp Gly Arg Asn Ile Tyr Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210> 1350
<211> 51
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H2

<400> 1350
cttatatcat ttgatggaag gaatatatac tacgcagact ccgtgaaggg c                51


<210> 1351
<211> 10
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H3

<400> 1351
Ala Arg Asp Gln Trp Leu Val Pro Asp Tyr 
1               5                   10  


<210> 1352
<211> 30
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H3

<400> 1352
gcgagagatc aatggctggt tcctgactac                                        30


<210> 1353
<211> 327
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region

<400> 1353
cagtctgttc tgattcagcc tgcctccgtg tctgggtctc ctggacagtc gatcaccatc       60

tcctgcactg gaaccagcag tgacgttggt ggttataact atgtctcctg gtaccaacag      120

cacccaggca acgcccccaa actcatgatt tatgaagtca gtaagcggcc ctcaggggtc      180

cctgatcgct tctctggctt caagtctggc aacacggcct ccctgaccgt ctctgggctc      240

caggctgagg atgaggctga ttattactgc agctcatatg caggcagcaa cagtgtcttc      300

ggaactggca cccagctgac cgtcctc                                          327


<210> 1354
<211> 109
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region

<400> 1354
Gln Ser Val Leu Ile Gln Pro Ala Ser Val Ser Gly Ser Pro Gly Gln 
1               5                   10                  15      


Ser Ile Thr Ile Ser Cys Thr Gly Thr Ser Ser Asp Val Gly Gly Tyr 
            20                  25                  30          


Asn Tyr Val Ser Trp Tyr Gln Gln His Pro Gly Asn Ala Pro Lys Leu 
        35                  40                  45              


Met Ile Tyr Glu Val Ser Lys Arg Pro Ser Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Phe Lys Ser Gly Asn Thr Ala Ser Leu Thr Val Ser Gly Leu 
65                  70                  75                  80  


Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Ser Ser Tyr Ala Gly Ser 
                85                  90                  95      


Asn Ser Val Phe Gly Thr Gly Thr Gln Leu Thr Val Leu 
            100                 105                 


<210> 1355
<211> 14
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region CDR L1

<400> 1355
Thr Gly Thr Ser Ser Asp Val Gly Gly Tyr Asn Tyr Val Ser 
1               5                   10                  


<210> 1356
<211> 42
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region CDR L1

<400> 1356
actggaacca gcagtgacgt tggtggttat aactatgtct cc                          42


<210> 1357
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region CDR L2

<400> 1357
Glu Val Ser Lys Arg Pro Ser 
1               5           


<210> 1358
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region CDR L2

<400> 1358
gaagtcagta agcggccctc a                                                 21


<210> 1359
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region CDR L3

<400> 1359
Ser Ser Tyr Ala Gly Ser Asn Ser Val 
1               5                   


<210> 1360
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region CDR L3

<400> 1360
agctcatatg caggcagcaa cagtgtc                                           27


<210> 1361
<211> 366
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region

<400> 1361
gaggtgcagc tggtggagtc gggcccagga ctagttaggc cttcacagac cctgtccata       60

aagtgcagtg tctctggcgg ctccatcaat agaggtgctt acttctggac ctggatccgc      120

cagcgcccag ggaagggcct ggagtggatt gggtccatcc atgacaccgg cagctactac      180

aacccgtccc tcaagacacg agtttccatc tccggggaca cgtctaaaaa cctcttcacc      240

ctggagttga cctcgctgac tgccgcggac acggccgtgt attactgtgc gagggggcgt      300

ggatacagct atggctggcg ttactttgac tcctggggcc agggaaccct ggtcaccgtc      360

tcctca                                                                 366


<210> 1362
<211> 122
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region

<400> 1362
Glu Val Gln Leu Val Glu Ser Gly Pro Gly Leu Val Arg Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Ile Lys Cys Ser Val Ser Gly Gly Ser Ile Asn Arg Gly 
            20                  25                  30          


Ala Tyr Phe Trp Thr Trp Ile Arg Gln Arg Pro Gly Lys Gly Leu Glu 
        35                  40                  45              


Trp Ile Gly Ser Ile His Asp Thr Gly Ser Tyr Tyr Asn Pro Ser Leu 
    50                  55                  60                  


Lys Thr Arg Val Ser Ile Ser Gly Asp Thr Ser Lys Asn Leu Phe Thr 
65                  70                  75                  80  


Leu Glu Leu Thr Ser Leu Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Arg Gly Tyr Ser Tyr Gly Trp Arg Tyr Phe Asp Ser Trp 
            100                 105                 110         


Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120         


<210> 1363
<211> 11
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H1

<400> 1363
Gly Ser Ile Asn Arg Gly Ala Tyr Phe Trp Thr 
1               5                   10      


<210> 1364
<211> 33
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H1

<400> 1364
ggctccatca atagaggtgc ttacttctgg acc                                    33


<210> 1365
<211> 15
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H2

<400> 1365
Ser Ile His Asp Thr Gly Ser Tyr Tyr Asn Pro Ser Leu Lys Thr 
1               5                   10                  15  


<210> 1366
<211> 45
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H2

<400> 1366
tccatccatg acaccggcag ctactacaac ccgtccctca agaca                       45


<210> 1367
<211> 15
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H3

<400> 1367
Ala Arg Gly Arg Gly Tyr Ser Tyr Gly Trp Arg Tyr Phe Asp Ser 
1               5                   10                  15  


<210> 1368
<211> 45
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H3

<400> 1368
gcgagggggc gtggatacag ctatggctgg cgttactttg actcc                       45


<210> 1369
<211> 324
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region

<400> 1369
tcctatgtgc tgactcagcc accctcggtg tcagtgtctc caggacagac ggccaggatc       60

acctgctctg gcgatgcatt cccaagacaa tattcttatt ggtaccagca gaaggcaggc      120

cagccccctg tgttggtaat attgaaagac tctgagaggc cctcagggat ccctgcgcga      180

ttctctggct ccacctcagg gacaacagtc accttgacca tcactggagt ccaggcagaa      240

gacgaggcag actattactg tcaatcatcg gacagcagtg gaaattatgt ggtgttcggc      300

ggagggacca agctcaccgt ccta                                             324


<210> 1370
<211> 108
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region

<400> 1370
Ser Tyr Val Leu Thr Gln Pro Pro Ser Val Ser Val Ser Pro Gly Gln 
1               5                   10                  15      


Thr Ala Arg Ile Thr Cys Ser Gly Asp Ala Phe Pro Arg Gln Tyr Ser 
            20                  25                  30          


Tyr Trp Tyr Gln Gln Lys Ala Gly Gln Pro Pro Val Leu Val Ile Leu 
        35                  40                  45              


Lys Asp Ser Glu Arg Pro Ser Gly Ile Pro Ala Arg Phe Ser Gly Ser 
    50                  55                  60                  


Thr Ser Gly Thr Thr Val Thr Leu Thr Ile Thr Gly Val Gln Ala Glu 
65                  70                  75                  80  


Asp Glu Ala Asp Tyr Tyr Cys Gln Ser Ser Asp Ser Ser Gly Asn Tyr 
                85                  90                  95      


Val Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105             


<210> 1371
<211> 11
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region CDR L1

<400> 1371
Ser Gly Asp Ala Phe Pro Arg Gln Tyr Ser Tyr 
1               5                   10      


<210> 1372
<211> 33
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region CDR L1

<400> 1372
tctggcgatg cattcccaag acaatattct tat                                    33


<210> 1373
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region CDR L2

<400> 1373
Lys Asp Ser Glu Arg Pro Ser 
1               5           


<210> 1374
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region CDR L2

<400> 1374
aaagactctg agaggccctc a                                                 21


<210> 1375
<211> 11
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region CDR L3

<400> 1375
Gln Ser Ser Asp Ser Ser Gly Asn Tyr Val Val 
1               5                   10      


<210> 1376
<211> 33
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region CDR L3

<400> 1376
caatcatcgg acagcagtgg aaattatgtg gtg                                    33


<210> 1377
<211> 384
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region

<400> 1377
caggtccagc ttgtgcagtc tggggctgaa ttgaagaggc ctgggtcatc ggtgaaggtc       60

tcctgcaagg cttcaggggt ctatttgacc tcggttgctg tcaactgggt gcgacaggtc      120

cctggacatg ggttcgagtg gatgggtggg atactcactg gctttggtaa agtcagacac      180

gcccaggcct ttgagaaccg tgccacgctc accgcggacg cgtcgaccaa cacagcctac      240

ttggagttga gcggacttca agctgaagac acggccgcct attattgtgc gataatcgac      300

ccccaagatt gtacggccgc cagctgcttt tgggtcaact ggctcgaccc ctggggccag      360

ggaaccctgg tcaccgtctc ctca                                             384


<210> 1378
<211> 128
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region

<400> 1378
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Leu Lys Arg Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Val Tyr Leu Thr Ser Val 
            20                  25                  30          


Ala Val Asn Trp Val Arg Gln Val Pro Gly His Gly Phe Glu Trp Met 
        35                  40                  45              


Gly Gly Ile Leu Thr Gly Phe Gly Lys Val Arg His Ala Gln Ala Phe 
    50                  55                  60                  


Glu Asn Arg Ala Thr Leu Thr Ala Asp Ala Ser Thr Asn Thr Ala Tyr 
65                  70                  75                  80  


Leu Glu Leu Ser Gly Leu Gln Ala Glu Asp Thr Ala Ala Tyr Tyr Cys 
                85                  90                  95      


Ala Ile Ile Asp Pro Gln Asp Cys Thr Ala Ala Ser Cys Phe Trp Val 
            100                 105                 110         


Asn Trp Leu Asp Pro Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125             


<210> 1379
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H1

<400> 1379
Val Tyr Leu Thr Ser Val Ala Val Asn 
1               5                   


<210> 1380
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H1

<400> 1380
gtctatttga cctcggttgc tgtcaac                                           27


<210> 1381
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H2

<400> 1381
Gly Ile Leu Thr Gly Phe Gly Lys Val Arg His Ala Gln Ala Phe Glu 
1               5                   10                  15      


Asn 
    


<210> 1382
<211> 51
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H2

<400> 1382
gggatactca ctggctttgg taaagtcaga cacgcccagg cctttgagaa c                51


<210> 1383
<211> 21
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H3

<400> 1383
Ala Ile Ile Asp Pro Gln Asp Cys Thr Ala Ala Ser Cys Phe Trp Val 
1               5                   10                  15      


Asn Trp Leu Asp Pro 
            20      


<210> 1384
<211> 63
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H3

<400> 1384
gcgataatcg acccccaaga ttgtacggcc gccagctgct tttgggtcaa ctggctcgac       60

ccc                                                                     63


<210> 1385
<211> 324
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region

<400> 1385
gaaattgtat tgacacagtc tccaggcacc ctgaccgtgt ctccagggga gagagccacc       60

ctctcctgca gggccagtca gagtgttctt agtagtcact tagcctggta ccagcagaaa      120

cctggccagg ctcccaggct cctcatctat gctgcatcca gtagggccac tgacgtccca      180

gacaggttca gtggcagtgg gtctgggaca gacttcactc tcaccatcag cagactggag      240

cctcaagatt ttgcagtcta ttactgtcag cagtatggtt cctctccgat caccttcggc      300

caagggacac gactggagat taaa                                             324


<210> 1386
<211> 108
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region

<400> 1386
Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Thr Val Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Leu Ser Ser 
            20                  25                  30          


His Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu 
        35                  40                  45              


Ile Tyr Ala Ala Ser Ser Arg Ala Thr Asp Val Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu 
65                  70                  75                  80  


Pro Gln Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Gly Ser Ser Pro 
                85                  90                  95      


Ile Thr Phe Gly Gln Gly Thr Arg Leu Glu Ile Lys 
            100                 105             


<210> 1387
<211> 12
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region CDR L1

<400> 1387
Arg Ala Ser Gln Ser Val Leu Ser Ser His Leu Ala 
1               5                   10          


<210> 1388
<211> 36
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region CDR L1

<400> 1388
agggccagtc agagtgttct tagtagtcac ttagcc                                 36


<210> 1389
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region CDR L2

<400> 1389
Ala Ala Ser Ser Arg Ala Thr 
1               5           


<210> 1390
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region CDR L2

<400> 1390
gctgcatcca gtagggccac t                                                 21


<210> 1391
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region CDR L3

<400> 1391
Gln Gln Tyr Gly Ser Ser Pro Ile Thr 
1               5                   


<210> 1392
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region CDR L3

<400> 1392
cagcagtatg gttcctctcc gatcacc                                           27


<210> 1393
<211> 378
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region

<400> 1393
caggtccagc tggtgcagtc tggggctgag gtgaagaagc ctgggtcctc ggtgaaggtc       60

tcctgtaagg ttgccggagg ttccttctcc aattatgcaa tcgcctggct gcgacaggcc      120

cctggacaag ggcttgagtg gatgggaggg atcatacctg cctttaatag agcaatgtat      180

gcacggaagt tccaagacag agtcacaatt accgcgtacg catcaacgac cactgcctac      240

ctggacatta ccggcctcag atctgaggac acggcccttt attattgtgc gaggcctgct      300

ggagactttg gggatttaaa gtgggtacga tcgccttttg actactgggg ccagggaacc      360

ctggtcaccg tctcctca                                                    378


<210> 1394
<211> 126
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region

<400> 1394
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Val Ala Gly Gly Ser Phe Ser Asn Tyr 
            20                  25                  30          


Ala Ile Ala Trp Leu Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Gly Ile Ile Pro Ala Phe Asn Arg Ala Met Tyr Ala Arg Lys Phe 
    50                  55                  60                  


Gln Asp Arg Val Thr Ile Thr Ala Tyr Ala Ser Thr Thr Thr Ala Tyr 
65                  70                  75                  80  


Leu Asp Ile Thr Gly Leu Arg Ser Glu Asp Thr Ala Leu Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Pro Ala Gly Asp Phe Gly Asp Leu Lys Trp Val Arg Ser Pro 
            100                 105                 110         


Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125     


<210> 1395
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H1

<400> 1395
Gly Ser Phe Ser Asn Tyr Ala Ile Ala 
1               5                   


<210> 1396
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H1

<400> 1396
ggttccttct ccaattatgc aatcgcc                                           27


<210> 1397
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H2

<400> 1397
Gly Ile Ile Pro Ala Phe Asn Arg Ala Met Tyr Ala Arg Lys Phe Gln 
1               5                   10                  15      


Asp 
    


<210> 1398
<211> 51
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H2

<400> 1398
gggatcatac ctgcctttaa tagagcaatg tatgcacgga agttccaaga c                51


<210> 1399
<211> 19
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H3

<400> 1399
Ala Arg Pro Ala Gly Asp Phe Gly Asp Leu Lys Trp Val Arg Ser Pro 
1               5                   10                  15      


Phe Asp Tyr 
            


<210> 1400
<211> 57
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H3

<400> 1400
gcgaggcctg ctggagactt tggggattta aagtgggtac gatcgccttt tgactac          57


<210> 1401
<211> 327
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region

<400> 1401
gaaacgacac tcacgcagtc tccaggcacc ctgtctgtgt ctccagggga aagagccacc       60

ctctcctgca gggccagtca ggaagttggc atcaacttag cctggtatca gcagaaacct      120

ggccaggctc ccaggctcct catatatggt gcatccacca gggccactga tgtcccagcc      180

aggttcagtg gcagtgggtc tgggacagag ttcactctca ccatcagcag cctgcagtct      240

gaagattttg cagtttatta ttgtcaggag tataatgact ggcctcccca gctcactttc      300

ggccctggga ccaaagtgga tatcaaa                                          327


<210> 1402
<211> 109
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region

<400> 1402
Glu Thr Thr Leu Thr Gln Ser Pro Gly Thr Leu Ser Val Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Glu Val Gly Ile Asn 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 
        35                  40                  45              


Tyr Gly Ala Ser Thr Arg Ala Thr Asp Val Pro Ala Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Ser 
65                  70                  75                  80  


Glu Asp Phe Ala Val Tyr Tyr Cys Gln Glu Tyr Asn Asp Trp Pro Pro 
                85                  90                  95      


Gln Leu Thr Phe Gly Pro Gly Thr Lys Val Asp Ile Lys 
            100                 105                 


<210> 1403
<211> 11
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region CDR L1

<400> 1403
Arg Ala Ser Gln Glu Val Gly Ile Asn Leu Ala 
1               5                   10      


<210> 1404
<211> 33
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region CDR L1

<400> 1404
agggccagtc aggaagttgg catcaactta gcc                                    33


<210> 1405
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region CDR L2

<400> 1405
Gly Ala Ser Thr Arg Ala Thr 
1               5           


<210> 1406
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region CDR L2

<400> 1406
ggtgcatcca ccagggccac t                                                 21


<210> 1407
<211> 11
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region CDR L3

<400> 1407
Gln Glu Tyr Asn Asp Trp Pro Pro Gln Leu Thr 
1               5                   10      


<210> 1408
<211> 33
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region CDR L3

<400> 1408
caggagtata atgactggcc tccccagctc act                                    33


<210> 1409
<211> 384
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region

<400> 1409
gaggtgcagc tggtggagtc tgggggaggc ttggtaaagc ctggggggtc cctaagactc       60

tcatgtgcag cctctggatt catcttccgc aacgcctgga tgagctgggt ccgccaggct      120

ccagggaagg ggctggagtg ggttggccgg attaaaagga caagtgaagg tgggtcagtc      180

gactacgcga cacccgtgca aggcagattc tccatctcaa gagatgattc tagaaacacg      240

ctgtatctgc aaatgaacag cctggaaacc gacgacacag ccgtgtatta ctgttccaca      300

ggcccaccct attcttactt tgatagtagt ggttattcgg tcgtggacta ctggggccag      360

ggaaccctgg tcaccgtctc ctca                                             384


<210> 1410
<211> 128
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region

<400> 1410
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ile Phe Arg Asn Ala 
            20                  25                  30          


Trp Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Gly Arg Ile Lys Arg Thr Ser Glu Gly Gly Ser Val Asp Tyr Ala Thr 
    50                  55                  60                  


Pro Val Gln Gly Arg Phe Ser Ile Ser Arg Asp Asp Ser Arg Asn Thr 
65                  70                  75                  80  


Leu Tyr Leu Gln Met Asn Ser Leu Glu Thr Asp Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Ser Thr Gly Pro Pro Tyr Ser Tyr Phe Asp Ser Ser Gly Tyr 
            100                 105                 110         


Ser Val Val Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125             


<210> 1411
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H1

<400> 1411
Phe Ile Phe Arg Asn Ala Trp Met Ser 
1               5                   


<210> 1412
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H1

<400> 1412
ttcatcttcc gcaacgcctg gatgagc                                           27


<210> 1413
<211> 19
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H2

<400> 1413
Arg Ile Lys Arg Thr Ser Glu Gly Gly Ser Val Asp Tyr Ala Thr Pro 
1               5                   10                  15      


Val Gln Gly 
            


<210> 1414
<211> 57
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H2

<400> 1414
cggattaaaa ggacaagtga aggtgggtca gtcgactacg cgacacccgt gcaaggc          57


<210> 1415
<211> 19
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H3

<400> 1415
Ser Thr Gly Pro Pro Tyr Ser Tyr Phe Asp Ser Ser Gly Tyr Ser Val 
1               5                   10                  15      


Val Asp Tyr 
            


<210> 1416
<211> 57
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H3

<400> 1416
tccacaggcc caccctattc ttactttgat agtagtggtt attcggtcgt ggactac          57


<210> 1417
<211> 333
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region

<400> 1417
cagtctgtcg tgacgcagcc gccctcagtg tctgggaccc ccgggcagag ggtcaccatc       60

tcctgcactg ggagctcctc caacatcggg acaccttttg atgtacactg gtaccagcag      120

attccagaga cagcccccaa actcatcata tctggtggtt tcagtcggcc ctcaggggtc      180

cctgaccgat tctctggctc ccagtctggc acctctgcct ccctggccat cagtgggctc      240

cggtccgagg atgaaggtga ttattattgt gcagcttggg atgacagcct gagtggtccg      300

gtgttcggcg gagggaccaa gctcaccgtc cta                                   333


<210> 1418
<211> 111
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region

<400> 1418
Gln Ser Val Val Thr Gln Pro Pro Ser Val Ser Gly Thr Pro Gly Gln 
1               5                   10                  15      


Arg Val Thr Ile Ser Cys Thr Gly Ser Ser Ser Asn Ile Gly Thr Pro 
            20                  25                  30          


Phe Asp Val His Trp Tyr Gln Gln Ile Pro Glu Thr Ala Pro Lys Leu 
        35                  40                  45              


Ile Ile Ser Gly Gly Phe Ser Arg Pro Ser Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Gln Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu 
65                  70                  75                  80  


Arg Ser Glu Asp Glu Gly Asp Tyr Tyr Cys Ala Ala Trp Asp Asp Ser 
                85                  90                  95      


Leu Ser Gly Pro Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 110     


<210> 1419
<211> 14
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region CDR L1

<400> 1419
Thr Gly Ser Ser Ser Asn Ile Gly Thr Pro Phe Asp Val His 
1               5                   10                  


<210> 1420
<211> 42
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region CDR L1

<400> 1420
actgggagct cctccaacat cgggacacct tttgatgtac ac                          42


<210> 1421
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region CDR L2

<400> 1421
Gly Gly Phe Ser Arg Pro Ser 
1               5           


<210> 1422
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region CDR L2

<400> 1422
ggtggtttca gtcggccctc a                                                 21


<210> 1423
<211> 11
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region CDR L3

<400> 1423
Ala Ala Trp Asp Asp Ser Leu Ser Gly Pro Val 
1               5                   10      


<210> 1424
<211> 33
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region CDR L3

<400> 1424
gcagcttggg atgacagcct gagtggtccg gtg                                    33


<210> 1425
<211> 378
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region

<400> 1425
caggtgcagc tggtgcagtc tggggctgag gtgaagaagc ctgggtcctc ggtgaaggtc       60

tcctgtaagg ttgtcggagg cagtttcagc aactatggga ttggctgggt gcgacaggcc      120

cctggacaag ggcctgagtg gatgggaggg atcatccctg cctttaagac agcaaaatat      180

gcaaagaagt tccaggacag agtcacaatt accgcggacg aatcttcgag cactgcctac      240

atggaggtga gaggcctcag acctgacgac acggccctgt attattgtgc gaggcctgaa      300

ggagactttg gagatttgaa gtgggtacga tcgccttttg actactgggg ccagggaacc      360

ctggtcaccg tctcctca                                                    378


<210> 1426
<211> 126
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region

<400> 1426
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Val Val Gly Gly Ser Phe Ser Asn Tyr 
            20                  25                  30          


Gly Ile Gly Trp Val Arg Gln Ala Pro Gly Gln Gly Pro Glu Trp Met 
        35                  40                  45              


Gly Gly Ile Ile Pro Ala Phe Lys Thr Ala Lys Tyr Ala Lys Lys Phe 
    50                  55                  60                  


Gln Asp Arg Val Thr Ile Thr Ala Asp Glu Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Val Arg Gly Leu Arg Pro Asp Asp Thr Ala Leu Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Pro Glu Gly Asp Phe Gly Asp Leu Lys Trp Val Arg Ser Pro 
            100                 105                 110         


Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125     


<210> 1427
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H1

<400> 1427
Gly Ser Phe Ser Asn Tyr Gly Ile Gly 
1               5                   


<210> 1428
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H1

<400> 1428
ggcagtttca gcaactatgg gattggc                                           27


<210> 1429
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H2

<400> 1429
Gly Ile Ile Pro Ala Phe Lys Thr Ala Lys Tyr Ala Lys Lys Phe Gln 
1               5                   10                  15      


Asp 
    


<210> 1430
<211> 51
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H2

<400> 1430
gggatcatcc ctgcctttaa gacagcaaaa tatgcaaaga agttccagga c                51


<210> 1431
<211> 19
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H3

<400> 1431
Ala Arg Pro Glu Gly Asp Phe Gly Asp Leu Lys Trp Val Arg Ser Pro 
1               5                   10                  15      


Phe Asp Tyr 
            


<210> 1432
<211> 57
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H3

<400> 1432
gcgaggcctg aaggagactt tggagatttg aagtgggtac gatcgccttt tgactac          57


<210> 1433
<211> 327
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region

<400> 1433
gaaacgacac tcacgcagtc tccagccacc ctgtctgtgt ctccagggga aagagtcacc       60

ctctcctgca gggccagtca ggatgttagc atcaacttag cctggtacca gcagaaacct      120

ggccaggctc ccaggctcct catctatggt gcatccacca gggccactga tgtcccagcc      180

aggttcagtg gcagtgggtc tgggacagac ttcactctca ccatcagcag cctgcagtct      240

gaagattttg cattttatta ttgtcaggag tataatgact ggcctcccca gctcactttc      300

ggccctggga ccaaggtgga aatcaaa                                          327


<210> 1434
<211> 109
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region

<400> 1434
Glu Thr Thr Leu Thr Gln Ser Pro Ala Thr Leu Ser Val Ser Pro Gly 
1               5                   10                  15      


Glu Arg Val Thr Leu Ser Cys Arg Ala Ser Gln Asp Val Ser Ile Asn 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 
        35                  40                  45              


Tyr Gly Ala Ser Thr Arg Ala Thr Asp Val Pro Ala Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Ser 
65                  70                  75                  80  


Glu Asp Phe Ala Phe Tyr Tyr Cys Gln Glu Tyr Asn Asp Trp Pro Pro 
                85                  90                  95      


Gln Leu Thr Phe Gly Pro Gly Thr Lys Val Glu Ile Lys 
            100                 105                 


<210> 1435
<211> 11
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region CDR L1

<400> 1435
Arg Ala Ser Gln Asp Val Ser Ile Asn Leu Ala 
1               5                   10      


<210> 1436
<211> 33
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region CDR L1

<400> 1436
agggccagtc aggatgttag catcaactta gcc                                    33


<210> 1437
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region CDR L2

<400> 1437
Gly Ala Ser Thr Arg Ala Thr 
1               5           


<210> 1438
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region CDR L2

<400> 1438
ggtgcatcca ccagggccac t                                                 21


<210> 1439
<211> 11
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region CDR L3

<400> 1439
Gln Glu Tyr Asn Asp Trp Pro Pro Gln Leu Thr 
1               5                   10      


<210> 1440
<211> 33
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region CDR L3

<400> 1440
caggagtata atgactggcc tccccagctc act                                    33


<210> 1441
<211> 384
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region

<400> 1441
caggtccagc tggtgcagtc tggggctgag gtgaagaagc ctgggtcatc ggtgaaggtc       60

tcctgcaagg cctcaggagt cattttgacc agcgttgctg tcagctgggt gcggcaggcc      120

cctggaaaag gctttgagtg gatgggaggg attcttcctg gctttaataa agtcagacac      180

gcccaggatt ttgagaacag agccactcac accgcggacg catctacgaa cacagtctac      240

atggagttga gcggactgaa atctgaggac acggccgtct attactgtgc gataatcgac      300

ccccaagatt gtactcgtgc cagttgcttt tgggtcaact ggctcgcccc ctggggccag      360

ggaaccctgg tcaccgtctc ctca                                             384


<210> 1442
<211> 128
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region

<400> 1442
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Val Ile Leu Thr Ser Val 
            20                  25                  30          


Ala Val Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Phe Glu Trp Met 
        35                  40                  45              


Gly Gly Ile Leu Pro Gly Phe Asn Lys Val Arg His Ala Gln Asp Phe 
    50                  55                  60                  


Glu Asn Arg Ala Thr His Thr Ala Asp Ala Ser Thr Asn Thr Val Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Gly Leu Lys Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ile Ile Asp Pro Gln Asp Cys Thr Arg Ala Ser Cys Phe Trp Val 
            100                 105                 110         


Asn Trp Leu Ala Pro Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125             


<210> 1443
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H1

<400> 1443
Val Ile Leu Thr Ser Val Ala Val Ser 
1               5                   


<210> 1444
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H1

<400> 1444
gtcattttga ccagcgttgc tgtcagc                                           27


<210> 1445
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H2

<400> 1445
Gly Ile Leu Pro Gly Phe Asn Lys Val Arg His Ala Gln Asp Phe Glu 
1               5                   10                  15      


Asn 
    


<210> 1446
<211> 51
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H2

<400> 1446
gggattcttc ctggctttaa taaagtcaga cacgcccagg attttgagaa c                51


<210> 1447
<211> 21
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H3

<400> 1447
Ala Ile Ile Asp Pro Gln Asp Cys Thr Arg Ala Ser Cys Phe Trp Val 
1               5                   10                  15      


Asn Trp Leu Ala Pro 
            20      


<210> 1448
<211> 63
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H3

<400> 1448
gcgataatcg acccccaaga ttgtactcgt gccagttgct tttgggtcaa ctggctcgcc       60

ccc                                                                     63


<210> 1449
<211> 324
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region

<400> 1449
gaaacgacac tcacgcagtc tcccggcacc ctgaccttgt ctccagggga gagagccacc       60

ctgtcctgca gggccagtca gagtgttcct agcaggaact tagcctggta ccagcagaaa      120

cctggccagg ctcccaggct catcatctat gctgcatcca atagggccac tgacatccca      180

gacaggttca gtggcagtgg gtctgggaca gatttcactc tcaccatcag cagactggag      240

cctcaagatt ttgcagtgta ttactgtcag cagtatgaaa cctctccgat caccttcggc      300

caagggacca aagtggatat caaa                                             324


<210> 1450
<211> 108
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region

<400> 1450
Glu Thr Thr Leu Thr Gln Ser Pro Gly Thr Leu Thr Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Pro Ser Arg 
            20                  25                  30          


Asn Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Ile 
        35                  40                  45              


Ile Tyr Ala Ala Ser Asn Arg Ala Thr Asp Ile Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu 
65                  70                  75                  80  


Pro Gln Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Glu Thr Ser Pro 
                85                  90                  95      


Ile Thr Phe Gly Gln Gly Thr Lys Val Asp Ile Lys 
            100                 105             


<210> 1451
<211> 12
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region CDR L1

<400> 1451
Arg Ala Ser Gln Ser Val Pro Ser Arg Asn Leu Ala 
1               5                   10          


<210> 1452
<211> 36
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region CDR L1

<400> 1452
agggccagtc agagtgttcc tagcaggaac ttagcc                                 36


<210> 1453
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region CDR L2

<400> 1453
Ala Ala Ser Asn Arg Ala Thr 
1               5           


<210> 1454
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region CDR L2

<400> 1454
gctgcatcca atagggccac t                                                 21


<210> 1455
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region CDR L3

<400> 1455
Gln Gln Tyr Glu Thr Ser Pro Ile Thr 
1               5                   


<210> 1456
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region CDR L3

<400> 1456
cagcagtatg aaacctctcc gatcacc                                           27


<210> 1457
<211> 384
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region

<400> 1457
gaggtgcagc tggtggagtc tgggggaggc ttggtaaagc ctggggggtc cctaagactc       60

tcatgtgcag cctctggatt catcttccgc aacgcctgga tgagctgggt ccgccaggct      120

ccagggaagg ggctggagtg ggttggccgg attaaaagga caagtgaagg tgggtcagtc      180

gactacgcga cacccgtgca aggcagattc tccatctcaa gagatgattc tagaaagacg      240

ctgtatctgc aaatgaacag cctggaaacc gacgacacag ccgtgtatta ctgttccaca      300

ggcccaccct attcttactt tgatagtagt ggttattcgg tcgtggacta ctggggcctg      360

ggaaccctgg tcaccgtctc ctca                                             384


<210> 1458
<211> 128
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region

<400> 1458
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ile Phe Arg Asn Ala 
            20                  25                  30          


Trp Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Gly Arg Ile Lys Arg Thr Ser Glu Gly Gly Ser Val Asp Tyr Ala Thr 
    50                  55                  60                  


Pro Val Gln Gly Arg Phe Ser Ile Ser Arg Asp Asp Ser Arg Lys Thr 
65                  70                  75                  80  


Leu Tyr Leu Gln Met Asn Ser Leu Glu Thr Asp Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Ser Thr Gly Pro Pro Tyr Ser Tyr Phe Asp Ser Ser Gly Tyr 
            100                 105                 110         


Ser Val Val Asp Tyr Trp Gly Leu Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125             


<210> 1459
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H1

<400> 1459
Phe Ile Phe Arg Asn Ala Trp Met Ser 
1               5                   


<210> 1460
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H1

<400> 1460
ttcatcttcc gcaacgcctg gatgagc                                           27


<210> 1461
<211> 19
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H2

<400> 1461
Arg Ile Lys Arg Thr Ser Glu Gly Gly Ser Val Asp Tyr Ala Thr Pro 
1               5                   10                  15      


Val Gln Gly 
            


<210> 1462
<211> 57
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H2

<400> 1462
cggattaaaa ggacaagtga aggtgggtca gtcgactacg cgacacccgt gcaaggc          57


<210> 1463
<211> 19
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H3

<400> 1463
Ser Thr Gly Pro Pro Tyr Ser Tyr Phe Asp Ser Ser Gly Tyr Ser Val 
1               5                   10                  15      


Val Asp Tyr 
            


<210> 1464
<211> 57
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H3

<400> 1464
tccacaggcc caccctattc ttactttgat agtagtggtt attcggtcgt ggactac          57


<210> 1465
<211> 330
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region

<400> 1465
tcctatgagc tgactcagcc accctcagcg tctgggaccc ccgggcagag ggtcaccatc       60

tcttgttctg caagcagctc caacatcgga gataattatt tctactggta ccaacaactc      120

ccaggaaagg cccccacact cctcatgtat ggtagtgatc aacggtcctc aggggtccct      180

gaccgattct ctggctccca gtctggcacc tctgcctccc tggccatcag tgggctccgg      240

tccgaggatg aagctgatta ttattgtgca gcttgggatg acagcctgag tggtccggtg      300

ttcggcggag gcacccagct gaccgtcctc                                       330


<210> 1466
<211> 110
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region

<400> 1466
Ser Tyr Glu Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln 
1               5                   10                  15      


Arg Val Thr Ile Ser Cys Ser Ala Ser Ser Ser Asn Ile Gly Asp Asn 
            20                  25                  30          


Tyr Phe Tyr Trp Tyr Gln Gln Leu Pro Gly Lys Ala Pro Thr Leu Leu 
        35                  40                  45              


Met Tyr Gly Ser Asp Gln Arg Ser Ser Gly Val Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gln Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Arg 
65                  70                  75                  80  


Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Asp Ser Leu 
                85                  90                  95      


Ser Gly Pro Val Phe Gly Gly Gly Thr Gln Leu Thr Val Leu 
            100                 105                 110 


<210> 1467
<211> 13
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region CDR L1

<400> 1467
Ser Ala Ser Ser Ser Asn Ile Gly Asp Asn Tyr Phe Tyr 
1               5                   10              


<210> 1468
<211> 39
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region CDR L1

<400> 1468
tctgcaagca gctccaacat cggagataat tatttctac                              39


<210> 1469
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region CDR L2

<400> 1469
Gly Ser Asp Gln Arg Ser Ser 
1               5           


<210> 1470
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region CDR L2

<400> 1470
ggtagtgatc aacggtcctc a                                                 21


<210> 1471
<211> 11
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region CDR L3

<400> 1471
Ala Ala Trp Asp Asp Ser Leu Ser Gly Pro Val 
1               5                   10      


<210> 1472
<211> 33
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region CDR L3

<400> 1472
gcagcttggg atgacagcct gagtggtccg gtg                                    33


<210> 1473
<211> 387
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region

<400> 1473
caggtccagc tggtgcagtc tggggctgag gtgaagaagc ctgggtcctc ggtgataatc       60

tcctgcaagg catctggagg caccttcaga aactacggtt tcacctgggt gcgacaggcc      120

cctggacaag ggcttgagtg gttgggaggg atcatcccta tgtttgagac agtcagatat      180

gcacagaagt tccagggaag agtcacaatc accgcggacg aaaacaccaa cacagccttc      240

ctggcggtga gcagcctgcg atctgaagac acgggcgtct atttttgtgc gcgagacctc      300

cagacgggga ttatgagcag cgtgaggtcg gaatataggg gctttatgga cccctggggc      360

cagggaaccc tggtcaccgt ctcctca                                          387


<210> 1474
<211> 129
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region

<400> 1474
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Ile Ile Ser Cys Lys Ala Ser Gly Gly Thr Phe Arg Asn Tyr 
            20                  25                  30          


Gly Phe Thr Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Leu 
        35                  40                  45              


Gly Gly Ile Ile Pro Met Phe Glu Thr Val Arg Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Ala Asp Glu Asn Thr Asn Thr Ala Phe 
65                  70                  75                  80  


Leu Ala Val Ser Ser Leu Arg Ser Glu Asp Thr Gly Val Tyr Phe Cys 
                85                  90                  95      


Ala Arg Asp Leu Gln Thr Gly Ile Met Ser Ser Val Arg Ser Glu Tyr 
            100                 105                 110         


Arg Gly Phe Met Asp Pro Trp Gly Gln Gly Thr Leu Val Thr Val Ser 
        115                 120                 125             


Ser 
    


<210> 1475
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H1

<400> 1475
Gly Thr Phe Arg Asn Tyr Gly Phe Thr 
1               5                   


<210> 1476
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H1

<400> 1476
ggcaccttca gaaactacgg tttcacc                                           27


<210> 1477
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H2

<400> 1477
Gly Ile Ile Pro Met Phe Glu Thr Val Arg Tyr Ala Gln Lys Phe Gln 
1               5                   10                  15      


Gly 
    


<210> 1478
<211> 51
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H2

<400> 1478
gggatcatcc ctatgtttga gacagtcaga tatgcacaga agttccaggg a                51


<210> 1479
<211> 22
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H3

<400> 1479
Ala Arg Asp Leu Gln Thr Gly Ile Met Ser Ser Val Arg Ser Glu Tyr 
1               5                   10                  15      


Arg Gly Phe Met Asp Pro 
            20          


<210> 1480
<211> 66
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H3

<400> 1480
gcgcgagacc tccagacggg gattatgagc agcgtgaggt cggaatatag gggctttatg       60

gacccc                                                                  66


<210> 1481
<211> 330
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region

<400> 1481
cagtctgtgc tgacgcagcc gccctcggtg tctggagccc cccggcagag ggtcaccatc       60

tcctgttctg gaagcagctc caacatcgga actaatgctg taaactggta ccaacagctc      120

ccaggaaagt ctcccaaagt cctcatctac tatgatgagc tggtgccctc aggggtctct      180

gaccgattct ctggctccag gtctggcacc tcagcctccc tggccataag tggactccgg      240

tctgaggatg aggcttacta ttactgtgca gcttgggatg acagtctgaa tggttgggtg      300

ttcggcggag gcacccagct caccgtccta                                       330


<210> 1482
<211> 110
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region

<400> 1482
Gln Ser Val Leu Thr Gln Pro Pro Ser Val Ser Gly Ala Pro Arg Gln 
1               5                   10                  15      


Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Thr Asn 
            20                  25                  30          


Ala Val Asn Trp Tyr Gln Gln Leu Pro Gly Lys Ser Pro Lys Val Leu 
        35                  40                  45              


Ile Tyr Tyr Asp Glu Leu Val Pro Ser Gly Val Ser Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Arg Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Arg 
65                  70                  75                  80  


Ser Glu Asp Glu Ala Tyr Tyr Tyr Cys Ala Ala Trp Asp Asp Ser Leu 
                85                  90                  95      


Asn Gly Trp Val Phe Gly Gly Gly Thr Gln Leu Thr Val Leu 
            100                 105                 110 


<210> 1483
<211> 13
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region CDR L1

<400> 1483
Ser Gly Ser Ser Ser Asn Ile Gly Thr Asn Ala Val Asn 
1               5                   10              


<210> 1484
<211> 39
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region CDR L1

<400> 1484
tctggaagca gctccaacat cggaactaat gctgtaaac                              39


<210> 1485
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region CDR L2

<400> 1485
Tyr Asp Glu Leu Val Pro Ser 
1               5           


<210> 1486
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region CDR L2

<400> 1486
tatgatgagc tggtgccctc a                                                 21


<210> 1487
<211> 11
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region CDR L3

<400> 1487
Ala Ala Trp Asp Asp Ser Leu Asn Gly Trp Val 
1               5                   10      


<210> 1488
<211> 33
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region CDR L3

<400> 1488
gcagcttggg atgacagtct gaatggttgg gtg                                    33


<210> 1489
<211> 366
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region

<400> 1489
gaggtgcagc tggtggagtc ggggggaggc gtggtccagc ctgggaggtc cctgagactc       60

tcctgtgcag tctctggatt cacgttcagt aactttggga tgcactgggt ccgccaggct      120

ccaggcaagg ggctggagtg ggtggcagct atttcatacg atggaagaaa aagattccag      180

gcagactccg tgaagggccg attcaccatc tccagagaca acttgaagaa cacgctgaat      240

ctccaaatga acagcctgaa aactgaggac acggctgtgt attactgtgc gaaatcgtct      300

agacttttgg actggttata caatatggac ttctggggcc aagggaccac ggtcaccgtc      360

tcctca                                                                 366


<210> 1490
<211> 122
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region

<400> 1490
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Val Ser Gly Phe Thr Phe Ser Asn Phe 
            20                  25                  30          


Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Ala Ile Ser Tyr Asp Gly Arg Lys Arg Phe Gln Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Leu Lys Asn Thr Leu Asn 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Thr Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Ser Ser Arg Leu Leu Asp Trp Leu Tyr Asn Met Asp Phe Trp 
            100                 105                 110         


Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120         


<210> 1491
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H1

<400> 1491
Phe Thr Phe Ser Asn Phe Gly Met His 
1               5                   


<210> 1492
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H1

<400> 1492
ttcacgttca gtaactttgg gatgcac                                           27


<210> 1493
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H2

<400> 1493
Ala Ile Ser Tyr Asp Gly Arg Lys Arg Phe Gln Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210> 1494
<211> 51
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H2

<400> 1494
gctatttcat acgatggaag aaaaagattc caggcagact ccgtgaaggg c                51


<210> 1495
<211> 15
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H3

<400> 1495
Ala Lys Ser Ser Arg Leu Leu Asp Trp Leu Tyr Asn Met Asp Phe 
1               5                   10                  15  


<210> 1496
<211> 45
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H3

<400> 1496
gcgaaatcgt ctagactttt ggactggtta tacaatatgg acttc                       45


<210> 1497
<211> 324
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region

<400> 1497
tcctatgtgc tgactcagcc accctcagtg tcagtggccc caggaaagac ggccaggatt       60

acctgtgggg gaaacatcct tgggagttca agtgtccact ggttccagca gaaggcaggc      120

caggcccctg tcctggtcat ctattatgat agcgaccggc cctcagggat ccctgagcga      180

ttctctggct cccattctgg ggacacggcc accctgacca tcagcagggt cgaagtcggg      240

gatgaggccg actattactg tcaggtgtgg gataatagta attcccaggg ggtcttcggc      300

ggaggcaccc agctgaccgt cctc                                             324


<210> 1498
<211> 108
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region

<400> 1498
Ser Tyr Val Leu Thr Gln Pro Pro Ser Val Ser Val Ala Pro Gly Lys 
1               5                   10                  15      


Thr Ala Arg Ile Thr Cys Gly Gly Asn Ile Leu Gly Ser Ser Ser Val 
            20                  25                  30          


His Trp Phe Gln Gln Lys Ala Gly Gln Ala Pro Val Leu Val Ile Tyr 
        35                  40                  45              


Tyr Asp Ser Asp Arg Pro Ser Gly Ile Pro Glu Arg Phe Ser Gly Ser 
    50                  55                  60                  


His Ser Gly Asp Thr Ala Thr Leu Thr Ile Ser Arg Val Glu Val Gly 
65                  70                  75                  80  


Asp Glu Ala Asp Tyr Tyr Cys Gln Val Trp Asp Asn Ser Asn Ser Gln 
                85                  90                  95      


Gly Val Phe Gly Gly Gly Thr Gln Leu Thr Val Leu 
            100                 105             


<210> 1499
<211> 11
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region CDR L1

<400> 1499
Gly Gly Asn Ile Leu Gly Ser Ser Ser Val His 
1               5                   10      


<210> 1500
<211> 33
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region CDR L1

<400> 1500
gggggaaaca tccttgggag ttcaagtgtc cac                                    33


<210> 1501
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region CDR L2

<400> 1501
Tyr Asp Ser Asp Arg Pro Ser 
1               5           


<210> 1502
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region CDR L2

<400> 1502
tatgatagcg accggccctc a                                                 21


<210> 1503
<211> 11
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region CDR L3

<400> 1503
Gln Val Trp Asp Asn Ser Asn Ser Gln Gly Val 
1               5                   10      


<210> 1504
<211> 33
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region CDR L3

<400> 1504
caggtgtggg ataatagtaa ttcccagggg gtc                                    33


<210> 1505
<211> 369
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region

<400> 1505
caggtgcagc tacagcagtg gggcccagga ctggtgaagc cgtcacagac cctgtccctc       60

acctgcagtg tctctggtgc ctcagtcaaa ataggttcta atttctggac gtggatccgc      120

cagcgcccag ggaagggcct ggagtggatt ggggccatcc atgacactgg caccacctac      180

tacaacccgt cccttgagcc tcaagtaatc atttcaactg acacgtctca gaaccaattc      240

tccctgaggc tgacctctgt gactgccgcg gacacggccg tttactactg tgcgaggggg      300

cgtggataca cctatggatg gcgttacttt gactactggg gccagggaac cctggtcacc      360

gtctcctca                                                              369


<210> 1506
<211> 123
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region

<400> 1506
Gln Val Gln Leu Gln Gln Trp Gly Pro Gly Leu Val Lys Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Ser Val Ser Gly Ala Ser Val Lys Ile Gly 
            20                  25                  30          


Ser Asn Phe Trp Thr Trp Ile Arg Gln Arg Pro Gly Lys Gly Leu Glu 
        35                  40                  45              


Trp Ile Gly Ala Ile His Asp Thr Gly Thr Thr Tyr Tyr Asn Pro Ser 
    50                  55                  60                  


Leu Glu Pro Gln Val Ile Ile Ser Thr Asp Thr Ser Gln Asn Gln Phe 
65                  70                  75                  80  


Ser Leu Arg Leu Thr Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr 
                85                  90                  95      


Cys Ala Arg Gly Arg Gly Tyr Thr Tyr Gly Trp Arg Tyr Phe Asp Tyr 
            100                 105                 110         


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120             


<210> 1507
<211> 11
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H1

<400> 1507
Ala Ser Val Lys Ile Gly Ser Asn Phe Trp Thr 
1               5                   10      


<210> 1508
<211> 33
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H1

<400> 1508
gcctcagtca aaataggttc taatttctgg acg                                    33


<210> 1509
<211> 16
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H2

<400> 1509
Ala Ile His Asp Thr Gly Thr Thr Tyr Tyr Asn Pro Ser Leu Glu Pro 
1               5                   10                  15      


<210> 1510
<211> 48
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H2

<400> 1510
gccatccatg acactggcac cacctactac aacccgtccc ttgagcct                    48


<210> 1511
<211> 15
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H3

<400> 1511
Ala Arg Gly Arg Gly Tyr Thr Tyr Gly Trp Arg Tyr Phe Asp Tyr 
1               5                   10                  15  


<210> 1512
<211> 45
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H3

<400> 1512
gcgagggggc gtggatacac ctatggatgg cgttactttg actac                       45


<210> 1513
<211> 324
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region

<400> 1513
tcctatgtgc tgactcagcc accctcggtg tcagtgtccc caggacagac ggccaggatc       60

acctgctctg gagatgcatt gccaaagcaa tatgcctttt ggtatcagca caaggcagga      120

caggcccctg tgttggtcat aaaaaaagac actgagaggc cctcagggat ccctgagcga      180

ttctctggct ccatctcagg gacaacagcc actttgatca tcagtggagt ccaggcagaa      240

gacgaggctg actattactg tcaatcttca gacagtagtg gtaatgttgt cttattcggc      300

ggaggcaccc agctgaccgt cctc                                             324


<210> 1514
<211> 108
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region

<400> 1514
Ser Tyr Val Leu Thr Gln Pro Pro Ser Val Ser Val Ser Pro Gly Gln 
1               5                   10                  15      


Thr Ala Arg Ile Thr Cys Ser Gly Asp Ala Leu Pro Lys Gln Tyr Ala 
            20                  25                  30          


Phe Trp Tyr Gln His Lys Ala Gly Gln Ala Pro Val Leu Val Ile Lys 
        35                  40                  45              


Lys Asp Thr Glu Arg Pro Ser Gly Ile Pro Glu Arg Phe Ser Gly Ser 
    50                  55                  60                  


Ile Ser Gly Thr Thr Ala Thr Leu Ile Ile Ser Gly Val Gln Ala Glu 
65                  70                  75                  80  


Asp Glu Ala Asp Tyr Tyr Cys Gln Ser Ser Asp Ser Ser Gly Asn Val 
                85                  90                  95      


Val Leu Phe Gly Gly Gly Thr Gln Leu Thr Val Leu 
            100                 105             


<210> 1515
<211> 11
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region CDR L1

<400> 1515
Ser Gly Asp Ala Leu Pro Lys Gln Tyr Ala Phe 
1               5                   10      


<210> 1516
<211> 33
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region CDR L1

<400> 1516
tctggagatg cattgccaaa gcaatatgcc ttt                                    33


<210> 1517
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region CDR L2

<400> 1517
Lys Asp Thr Glu Arg Pro Ser 
1               5           


<210> 1518
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region CDR L2

<400> 1518
aaagacactg agaggccctc a                                                 21


<210> 1519
<211> 11
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region CDR L3

<400> 1519
Gln Ser Ser Asp Ser Ser Gly Asn Val Val Leu 
1               5                   10      


<210> 1520
<211> 33
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region CDR L3

<400> 1520
caatcttcag acagtagtgg taatgttgtc tta                                    33


<210> 1521
<211> 372
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region

<400> 1521
caggtgcagc tggtgcaatc tgggggaggc gtggtccagc ctgggaggtc cctgagactc       60

tcctgtgcag cgtctggatt cagcttcagt agttatggca tgcactgggt ccgccaggct      120

ccaggcaagg ggctggagtg ggtggcagct atattttatc atgaaattaa ggactattat      180

gcagactccg tgaacggccg attcagcatc tccagagaca attccaagaa caccctgtat      240

ctggaaatgt acagcctgaa ggtcgaggac acggctgtgt attattgtgc gagagatagt      300

gggaccctca caggactccc gcatgatgcc tttgatatct ggggccaagg gaccacggtc      360

accgtctcct ca                                                          372


<210> 1522
<211> 124
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region

<400> 1522
Gln Val Gln Leu Val Gln Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ser Phe Ser Ser Tyr 
            20                  25                  30          


Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Ala Ile Phe Tyr His Glu Ile Lys Asp Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Asn Gly Arg Phe Ser Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Glu Met Tyr Ser Leu Lys Val Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Ser Gly Thr Leu Thr Gly Leu Pro His Asp Ala Phe Asp 
            100                 105                 110         


Ile Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120                 


<210> 1523
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H1

<400> 1523
Phe Ser Phe Ser Ser Tyr Gly Met His 
1               5                   


<210> 1524
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H1

<400> 1524
ttcagcttca gtagttatgg catgcac                                           27


<210> 1525
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H2

<400> 1525
Ala Ile Phe Tyr His Glu Ile Lys Asp Tyr Tyr Ala Asp Ser Val Asn 
1               5                   10                  15      


Gly 
    


<210> 1526
<211> 51
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H2

<400> 1526
gctatatttt atcatgaaat taaggactat tatgcagact ccgtgaacgg c                51


<210> 1527
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H3

<400> 1527
Ala Arg Asp Ser Gly Thr Leu Thr Gly Leu Pro His Asp Ala Phe Asp 
1               5                   10                  15      


Ile 
    


<210> 1528
<211> 51
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H3

<400> 1528
gcgagagata gtgggaccct cacaggactc ccgcatgatg cctttgatat c                51


<210> 1529
<211> 321
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region

<400> 1529
gacatccaga tgacccagtc tccttccacc ctgagtgcat ctttaggagg cagagtcacc       60

atcacttgcc gggccagtca gagtgttact aacaggttgg cctggtatca acacaaacca      120

gggaaagccc ctaacctcct gatctataag gcgtctactt tagaaatcgg ggtcccatca      180

aggttcagcg gcagtggatc tgggacagag ttcactctca ccatcagcag cctgcagcct      240

gatgattttg cgacttatta ctgccaacag tatagtagtt attcgtggac gttcggccaa      300

gggaccaagg tggaaatcaa a                                                321


<210> 1530
<211> 107
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region

<400> 1530
Asp Ile Gln Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Leu Gly 
1               5                   10                  15      


Gly Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Val Thr Asn Arg 
            20                  25                  30          


Leu Ala Trp Tyr Gln His Lys Pro Gly Lys Ala Pro Asn Leu Leu Ile 
        35                  40                  45              


Tyr Lys Ala Ser Thr Leu Glu Ile Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Asp Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Ser Ser Tyr Ser Trp 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210> 1531
<211> 11
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region CDR L1

<400> 1531
Arg Ala Ser Gln Ser Val Thr Asn Arg Leu Ala 
1               5                   10      


<210> 1532
<211> 33
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region CDR L1

<400> 1532
cgggccagtc agagtgttac taacaggttg gcc                                    33


<210> 1533
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region CDR L2

<400> 1533
Lys Ala Ser Thr Leu Glu Ile 
1               5           


<210> 1534
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region CDR L2

<400> 1534
aaggcgtcta ctttagaaat c                                                 21


<210> 1535
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region CDR L3

<400> 1535
Gln Gln Tyr Ser Ser Tyr Ser Trp Thr 
1               5                   


<210> 1536
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region CDR L3

<400> 1536
caacagtata gtagttattc gtggacg                                           27


<210> 1537
<211> 384
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region

<400> 1537
gaggtgcagc tggtggagtc tgggggaggc ttggtaaagc ctggggggtc cctaagactc       60

tcatgtgcag cctctggatt catcttccgc aacgcctgga tgagctgggt ccgccaggct      120

ccagggaagg ggctggagtg ggttggccgg attaaaagga caagtgaagg tgggtcagtc      180

gactacgcga cacccgtgca aggcagattc tccatctcaa gagatgattc tagaaagacg      240

ctgtatctgc aaatgaacag cctggaaacc gacgacacag ccgtgtatta ctgttccaca      300

ggcccaccct attcttactt tgatagtagt ggttattcgg tcgtggacta ctggggcctg      360

ggaaccctgg tcaccgtctc ctca                                             384


<210> 1538
<211> 128
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region

<400> 1538
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ile Phe Arg Asn Ala 
            20                  25                  30          


Trp Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Gly Arg Ile Lys Arg Thr Ser Glu Gly Gly Ser Val Asp Tyr Ala Thr 
    50                  55                  60                  


Pro Val Gln Gly Arg Phe Ser Ile Ser Arg Asp Asp Ser Arg Lys Thr 
65                  70                  75                  80  


Leu Tyr Leu Gln Met Asn Ser Leu Glu Thr Asp Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Ser Thr Gly Pro Pro Tyr Ser Tyr Phe Asp Ser Ser Gly Tyr 
            100                 105                 110         


Ser Val Val Asp Tyr Trp Gly Leu Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125             


<210> 1539
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H1

<400> 1539
Phe Ile Phe Arg Asn Ala Trp Met Ser 
1               5                   


<210> 1540
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H1

<400> 1540
ttcatcttcc gcaacgcctg gatgagc                                           27


<210> 1541
<211> 19
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H2

<400> 1541
Arg Ile Lys Arg Thr Ser Glu Gly Gly Ser Val Asp Tyr Ala Thr Pro 
1               5                   10                  15      


Val Gln Gly 
            


<210> 1542
<211> 57
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H2

<400> 1542
cggattaaaa ggacaagtga aggtgggtca gtcgactacg cgacacccgt gcaaggc          57


<210> 1543
<211> 19
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H3

<400> 1543
Ser Thr Gly Pro Pro Tyr Ser Tyr Phe Asp Ser Ser Gly Tyr Ser Val 
1               5                   10                  15      


Val Asp Tyr 
            


<210> 1544
<211> 57
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H3

<400> 1544
tccacaggcc caccctattc ttactttgat agtagtggtt attcggtcgt ggactac          57


<210> 1545
<211> 330
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region

<400> 1545
cagccagtgc tgactcagcc cccctcagcg tctgggaccc ccgggcagag ggtcaccatc       60

tcttgttctg caagcagctc caacatcgga gataattatt tctactggta ccaacaactc      120

ccaggaaagg cccccacact cctcatgtat ggtagtgatc aacggtcctc aggggtccct      180

gaccgattct ctggctccca gtctggcacc tctgcctccc tggccatcag tgggctccgg      240

tccgaggatg aagctgatta ttattgtgca gcttgggatg acagcctgag tggtccggtg      300

ttcggcggag ggaccaagct caccgtccta                                       330


<210> 1546
<211> 110
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region

<400> 1546
Gln Pro Val Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln 
1               5                   10                  15      


Arg Val Thr Ile Ser Cys Ser Ala Ser Ser Ser Asn Ile Gly Asp Asn 
            20                  25                  30          


Tyr Phe Tyr Trp Tyr Gln Gln Leu Pro Gly Lys Ala Pro Thr Leu Leu 
        35                  40                  45              


Met Tyr Gly Ser Asp Gln Arg Ser Ser Gly Val Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gln Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Arg 
65                  70                  75                  80  


Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Asp Ser Leu 
                85                  90                  95      


Ser Gly Pro Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 110 


<210> 1547
<211> 13
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region CDR L1

<400> 1547
Ser Ala Ser Ser Ser Asn Ile Gly Asp Asn Tyr Phe Tyr 
1               5                   10              


<210> 1548
<211> 39
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region CDR L1

<400> 1548
tctgcaagca gctccaacat cggagataat tatttctac                              39


<210> 1549
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region CDR L2

<400> 1549
Gly Ser Asp Gln Arg Ser Ser 
1               5           


<210> 1550
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region CDR L2

<400> 1550
ggtagtgatc aacggtcctc a                                                 21


<210> 1551
<211> 11
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region CDR L3

<400> 1551
Ala Ala Trp Asp Asp Ser Leu Ser Gly Pro Val 
1               5                   10      


<210> 1552
<211> 33
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region CDR L3

<400> 1552
gcagcttggg atgacagcct gagtggtccg gtg                                    33


<210> 1553
<211> 366
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region

<400> 1553
gaggtgcagc tggtggagtc ggggggaggc gtggtccagc ctgggaggtc cctgagactc       60

tcctgtgcag tctctggatt cacattcagt aactttggga tgcactgggt ccgccaggct      120

ccaggcaagg ggctggagtg ggtggcagct atttcatacg atggaagaaa aacattccag      180

gcagactccg tgaagggccg attcatcatc tccagagaca acttgaagaa cacgttgaat      240

ctccaaatga acagcctgaa aactgaggac acggctgtgt attactgtgc gaaatcgtct      300

agatttttgg actggttata caatatggac ttctggggcc aagggaccac ggtcaccgtc      360

tcctca                                                                 366


<210> 1554
<211> 122
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region

<400> 1554
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Val Ser Gly Phe Thr Phe Ser Asn Phe 
            20                  25                  30          


Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Ala Ile Ser Tyr Asp Gly Arg Lys Thr Phe Gln Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Ile Ile Ser Arg Asp Asn Leu Lys Asn Thr Leu Asn 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Thr Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Ser Ser Arg Phe Leu Asp Trp Leu Tyr Asn Met Asp Phe Trp 
            100                 105                 110         


Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120         


<210> 1555
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H1

<400> 1555
Phe Thr Phe Ser Asn Phe Gly Met His 
1               5                   


<210> 1556
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H1

<400> 1556
ttcacattca gtaactttgg gatgcac                                           27


<210> 1557
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H2

<400> 1557
Ala Ile Ser Tyr Asp Gly Arg Lys Thr Phe Gln Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210> 1558
<211> 51
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H2

<400> 1558
gctatttcat acgatggaag aaaaacattc caggcagact ccgtgaaggg c                51


<210> 1559
<211> 15
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H3

<400> 1559
Ala Lys Ser Ser Arg Phe Leu Asp Trp Leu Tyr Asn Met Asp Phe 
1               5                   10                  15  


<210> 1560
<211> 45
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H3

<400> 1560
gcgaaatcgt ctagattttt ggactggtta tacaatatgg acttc                       45


<210> 1561
<211> 324
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region

<400> 1561
tcctatgagc tgacacagcc accctcagtg tcagaggccc caggaaagac ggccacgatt       60

acctgtgggg gaatcatcct tgggacttca agtgtccact ggttccagca gaagtcaggc      120

caggcccctg tcctggtcat ctattatgat agcgaccggc cctcagggat ccctgagcga      180

ttctctggct cccattctgg ggacacggcc accctgacca tcagcagggt cgaagtcggg      240

gatgaggccg actattactg tcaggtgtgg gataatagtc attcccaggg ggtcttcggc      300

ggaggcaccc agctgaccgt cctc                                             324


<210> 1562
<211> 108
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region

<400> 1562
Ser Tyr Glu Leu Thr Gln Pro Pro Ser Val Ser Glu Ala Pro Gly Lys 
1               5                   10                  15      


Thr Ala Thr Ile Thr Cys Gly Gly Ile Ile Leu Gly Thr Ser Ser Val 
            20                  25                  30          


His Trp Phe Gln Gln Lys Ser Gly Gln Ala Pro Val Leu Val Ile Tyr 
        35                  40                  45              


Tyr Asp Ser Asp Arg Pro Ser Gly Ile Pro Glu Arg Phe Ser Gly Ser 
    50                  55                  60                  


His Ser Gly Asp Thr Ala Thr Leu Thr Ile Ser Arg Val Glu Val Gly 
65                  70                  75                  80  


Asp Glu Ala Asp Tyr Tyr Cys Gln Val Trp Asp Asn Ser His Ser Gln 
                85                  90                  95      


Gly Val Phe Gly Gly Gly Thr Gln Leu Thr Val Leu 
            100                 105             


<210> 1563
<211> 11
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region CDR L1

<400> 1563
Gly Gly Ile Ile Leu Gly Thr Ser Ser Val His 
1               5                   10      


<210> 1564
<211> 33
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region CDR L1

<400> 1564
gggggaatca tccttgggac ttcaagtgtc cac                                    33


<210> 1565
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region CDR L2

<400> 1565
Tyr Asp Ser Asp Arg Pro Ser 
1               5           


<210> 1566
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region CDR L2

<400> 1566
tatgatagcg accggccctc a                                                 21


<210> 1567
<211> 11
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region CDR L3

<400> 1567
Gln Val Trp Asp Asn Ser His Ser Gln Gly Val 
1               5                   10      


<210> 1568
<211> 33
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region CDR L3

<400> 1568
caggtgtggg ataatagtca ttcccagggg gtc                                    33


<210> 1569
<211> 372
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region

<400> 1569
caggtgcagc tggtggagtc tgggggaggc gtggtccagc ctgggaggtc cctgagactc       60

tcctgtgcag cgtctggatt cgccttccgt gtctatgaca tccactgggt ccgccaggct      120

ccaggcaagg ggctggagtg ggtggcagtt gcctggtctg atggacgtga tgaattctat      180

gcagactccg tgaagggccg aatcaccatc tccagagaca attcaaagaa cactgtatat      240

ctgcagatga gcagcctgag agtcgcggat acggctgtgt attactgtgc gagagatagt      300

gggaccctaa cagggctccc tcatgatgct tttgatgtct ggggccaggg gaccacggtc      360

accgtctcct ca                                                          372


<210> 1570
<211> 124
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region

<400> 1570
Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ala Phe Arg Val Tyr 
            20                  25                  30          


Asp Ile His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Val Ala Trp Ser Asp Gly Arg Asp Glu Phe Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Ile Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Ser Ser Leu Arg Val Ala Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Ser Gly Thr Leu Thr Gly Leu Pro His Asp Ala Phe Asp 
            100                 105                 110         


Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120                 


<210> 1571
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H1

<400> 1571
Phe Ala Phe Arg Val Tyr Asp Ile His 
1               5                   


<210> 1572
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H1

<400> 1572
ttcgccttcc gtgtctatga catccac                                           27


<210> 1573
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H2

<400> 1573
Val Ala Trp Ser Asp Gly Arg Asp Glu Phe Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210> 1574
<211> 51
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H2

<400> 1574
gttgcctggt ctgatggacg tgatgaattc tatgcagact ccgtgaaggg c                51


<210> 1575
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H3

<400> 1575
Ala Arg Asp Ser Gly Thr Leu Thr Gly Leu Pro His Asp Ala Phe Asp 
1               5                   10                  15      


Val 
    


<210> 1576
<211> 51
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H3

<400> 1576
gcgagagata gtgggaccct aacagggctc cctcatgatg cttttgatgt c                51


<210> 1577
<211> 321
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region

<400> 1577
gacatccagt tgacccagtc tccttccacc ctgtctgcat ctgtaggaga cagagtcacc       60

atcacttgcc gggccagtca gagtattacc accaggttgg cctggtatca gcagaaatta      120

gggaaagccc ctaagctcct ggtctataag gcgtcaactt tagaaattgg ggtcccctca      180

aggttcagcg gcaggggatc tgggacagaa ttcactctca ccatcagcag cctgcagcct      240

gatgattttg caacttatta ctgccatcac tacaatagtt attcgtggac gttcggccaa      300

gggaccaaag tggatatcaa a                                                321


<210> 1578
<211> 107
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region

<400> 1578
Asp Ile Gln Leu Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Thr Thr Arg 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Leu Gly Lys Ala Pro Lys Leu Leu Val 
        35                  40                  45              


Tyr Lys Ala Ser Thr Leu Glu Ile Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Arg Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Asp Asp Phe Ala Thr Tyr Tyr Cys His His Tyr Asn Ser Tyr Ser Trp 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Asp Ile Lys 
            100                 105         


<210> 1579
<211> 11
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region CDR L1

<400> 1579
Arg Ala Ser Gln Ser Ile Thr Thr Arg Leu Ala 
1               5                   10      


<210> 1580
<211> 33
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region CDR L1

<400> 1580
cgggccagtc agagtattac caccaggttg gcc                                    33


<210> 1581
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region CDR L2

<400> 1581
Lys Ala Ser Thr Leu Glu Ile 
1               5           


<210> 1582
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region CDR L2

<400> 1582
aaggcgtcaa ctttagaaat t                                                 21


<210> 1583
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region CDR L3

<400> 1583
His His Tyr Asn Ser Tyr Ser Trp Thr 
1               5                   


<210> 1584
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region CDR L3

<400> 1584
catcactaca atagttattc gtggacg                                           27


<210> 1585
<211> 372
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region

<400> 1585
caggtgcagc tggtggagtc tgggggaggc gtggtccagc ctgggaggtc cctgagactc       60

tcctgtgctg cctctggatt cactttcact gactatgcta tgcactgggt ccgccaggct      120

ccaggcaagg gactacagtg ggtggcactt atatcatata acggacgtat acaatattac      180

gcagactccg tgaagggccg attcaccatc tccagagacg attccaagaa cacgctgtat      240

ctgcagatga acagcctgag agctggggac acggctgtct attactgtgc gagagatggg      300

gatcttgtgg ctgtcccagc tgctatcggc ttcgactcct ggggccaggg aaccctggtc      360

accgtctcct ca                                                          372


<210> 1586
<211> 124
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region

<400> 1586
Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Thr Asp Tyr 
            20                  25                  30          


Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Gln Trp Val 
        35                  40                  45              


Ala Leu Ile Ser Tyr Asn Gly Arg Ile Gln Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Gly Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Gly Asp Leu Val Ala Val Pro Ala Ala Ile Gly Phe Asp 
            100                 105                 110         


Ser Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 


<210> 1587
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H1

<400> 1587
Phe Thr Phe Thr Asp Tyr Ala Met His 
1               5                   


<210> 1588
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H1

<400> 1588
ttcactttca ctgactatgc tatgcac                                           27


<210> 1589
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H2

<400> 1589
Leu Ile Ser Tyr Asn Gly Arg Ile Gln Tyr Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210> 1590
<211> 51
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H2

<400> 1590
cttatatcat ataacggacg tatacaatat tacgcagact ccgtgaaggg c                51


<210> 1591
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H3

<400> 1591
Ala Arg Asp Gly Asp Leu Val Ala Val Pro Ala Ala Ile Gly Phe Asp 
1               5                   10                  15      


Ser 
    


<210> 1592
<211> 51
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H3

<400> 1592
gcgagagatg gggatcttgt ggctgtccca gctgctatcg gcttcgactc c                51


<210> 1593
<211> 339
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region

<400> 1593
gacatccagg tgacccagtc tccagactcc ctggctgtgt ctctgggcga gagggccacc       60

atcaactgca agtccagcca gagtgtttta tacacctcca acaacaagaa ctacttagct      120

tggtaccagc agaaatcgag acagcctcct aagctgctca tttactgggc atctacccgg      180

gaatccgggg tccctgagcg attcagtggc agcgggtctg ggacagattt cactctcacc      240

atcagcagcc tgcaggctga agatgtggca gtttattact gtcagcaata ttctagtcct      300

ccgtacactt ttggccaggg gaccaaggtg gagattaaa                             339


<210> 1594
<211> 113
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region

<400> 1594
Asp Ile Gln Val Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Glu Arg Ala Thr Ile Asn Cys Lys Ser Ser Gln Ser Val Leu Tyr Thr 
            20                  25                  30          


Ser Asn Asn Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Ser Arg Gln 
        35                  40                  45              


Pro Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Glu Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Leu Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys Gln Gln 
                85                  90                  95      


Tyr Ser Ser Pro Pro Tyr Thr Phe Gly Gln Gly Thr Lys Val Glu Ile 
            100                 105                 110         


Lys 
    


<210> 1595
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region CDR L1

<400> 1595
Lys Ser Ser Gln Ser Val Leu Tyr Thr Ser Asn Asn Lys Asn Tyr Leu 
1               5                   10                  15      


Ala 
    


<210> 1596
<211> 51
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region CDR L1

<400> 1596
aagtccagcc agagtgtttt atacacctcc aacaacaaga actacttagc t                51


<210> 1597
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region CDR L2

<400> 1597
Trp Ala Ser Thr Arg Glu Ser 
1               5           


<210> 1598
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region CDR L2

<400> 1598
tgggcatcta cccgggaatc c                                                 21


<210> 1599
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region CDR L3

<400> 1599
Gln Gln Tyr Ser Ser Pro Pro Tyr Thr 
1               5                   


<210> 1600
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region CDR L3

<400> 1600
cagcaatatt ctagtcctcc gtacact                                           27


<210> 1601
<211> 366
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region

<400> 1601
gaggtgcagc tggtggagtc tgggggaggc ctggtcaggc cgggggggtc cctgagactc       60

tcctgcgcag cgtctggatt cgccttcagt agctatagtt tacactgggt ccgccaggct      120

ccagggaggg gactggagtg ggtcgcatcg atcagtgcag gtagcagttt cacagattac      180

gcggcctcag tgaggggccg attcactatc tccagaaaca tcgccaactc actgtatctg      240

caaatgaaca ggctgagagc cgaggacacg gctgtctatt actgtgcgag agttatcgga      300

gacgggacga ttcttggagt ggtttttgac tactggggcc cgggaaccct ggtcaccgtc      360

tcctca                                                                 366


<210> 1602
<211> 122
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region

<400> 1602
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Arg Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ala Phe Ser Ser Tyr 
            20                  25                  30          


Ser Leu His Trp Val Arg Gln Ala Pro Gly Arg Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Ser Ile Ser Ala Gly Ser Ser Phe Thr Asp Tyr Ala Ala Ser Val 
    50                  55                  60                  


Arg Gly Arg Phe Thr Ile Ser Arg Asn Ile Ala Asn Ser Leu Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Arg Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Val Ile Gly Asp Gly Thr Ile Leu Gly Val Val Phe Asp Tyr Trp 
            100                 105                 110         


Gly Pro Gly Thr Leu Val Thr Val Ser Ser 
        115                 120         


<210> 1603
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H1

<400> 1603
Phe Ala Phe Ser Ser Tyr Ser Leu His 
1               5                   


<210> 1604
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H1

<400> 1604
ttcgccttca gtagctatag tttacac                                           27


<210> 1605
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H2

<400> 1605
Ser Ile Ser Ala Gly Ser Ser Phe Thr Asp Tyr Ala Ala Ser Val Arg 
1               5                   10                  15      


Gly 
    


<210> 1606
<211> 51
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H2

<400> 1606
tcgatcagtg caggtagcag tttcacagat tacgcggcct cagtgagggg c                51


<210> 1607
<211> 16
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H3

<400> 1607
Ala Arg Val Ile Gly Asp Gly Thr Ile Leu Gly Val Val Phe Asp Tyr 
1               5                   10                  15      


<210> 1608
<211> 48
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H3

<400> 1608
gcgagagtta tcggagacgg gacgattctt ggagtggttt ttgactac                    48


<210> 1609
<211> 330
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region

<400> 1609
cagtctgtcc tgacgcagcc gccctcagtg tctggggccc cagggcagag ggtcaccatc       60

tcctgcactg ggggcaggtc caacatcggg gccggttatg atgtacactg gtaccagcaa      120

cttccaggga cagcccccaa actcctcatc tatggtaaca tcaatcggcc ctcaggggtc      180

cctgaccgat tctctggctc caagtctggc acctcagcct ccctggccat cactgggctc      240

ctggctgagg atgaggctga ttattactgc cagtcctatg acagcagcct gagtgtgatt      300

ttcggcggag ggaccaagct caccgtccta                                       330


<210> 1610
<211> 110
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region

<400> 1610
Gln Ser Val Leu Thr Gln Pro Pro Ser Val Ser Gly Ala Pro Gly Gln 
1               5                   10                  15      


Arg Val Thr Ile Ser Cys Thr Gly Gly Arg Ser Asn Ile Gly Ala Gly 
            20                  25                  30          


Tyr Asp Val His Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu 
        35                  40                  45              


Leu Ile Tyr Gly Asn Ile Asn Arg Pro Ser Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Thr Gly Leu 
65                  70                  75                  80  


Leu Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Gln Ser Tyr Asp Ser Ser 
                85                  90                  95      


Leu Ser Val Ile Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 110 


<210> 1611
<211> 14
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region CDR L1

<400> 1611
Thr Gly Gly Arg Ser Asn Ile Gly Ala Gly Tyr Asp Val His 
1               5                   10                  


<210> 1612
<211> 42
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region CDR L1

<400> 1612
actgggggca ggtccaacat cggggccggt tatgatgtac ac                          42


<210> 1613
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region CDR L2

<400> 1613
Gly Asn Ile Asn Arg Pro Ser 
1               5           


<210> 1614
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region CDR L2

<400> 1614
ggtaacatca atcggccctc a                                                 21


<210> 1615
<211> 10
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region CDR L3

<400> 1615
Gln Ser Tyr Asp Ser Ser Leu Ser Val Ile 
1               5                   10  


<210> 1616
<211> 30
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region CDR L3

<400> 1616
cagtcctatg acagcagcct gagtgtgatt                                        30


<210> 1617
<211> 372
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region

<400> 1617
caggtccagc tggtgcagtc tggagcagag gtgaaaaagc ccggggagtc tctgaagatc       60

tcctgtaagg gttctggata cgtctttagt agttactggg tcgcctgggt gcgccagatg      120

cccgggaaag gcctggagtg gatggggatc atctatcctc atgactctga taccagatac      180

agcccggcct tccaaggcca ggtcaccatt tcagccgata agtccatcaa caccgcctac      240

ctgcagtgga gcagcctgaa ggcctcggac accgccatgt attactgcac cattatacta      300

ataccagctc ctatacgggc ccctgatggt tttgatatct ggggccaagg gaccacggtc      360

accgtctcct ca                                                          372


<210> 1618
<211> 124
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region

<400> 1618
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu 
1               5                   10                  15      


Ser Leu Lys Ile Ser Cys Lys Gly Ser Gly Tyr Val Phe Ser Ser Tyr 
            20                  25                  30          


Trp Val Ala Trp Val Arg Gln Met Pro Gly Lys Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Ile Ile Tyr Pro His Asp Ser Asp Thr Arg Tyr Ser Pro Ala Phe 
    50                  55                  60                  


Gln Gly Gln Val Thr Ile Ser Ala Asp Lys Ser Ile Asn Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Trp Ser Ser Leu Lys Ala Ser Asp Thr Ala Met Tyr Tyr Cys 
                85                  90                  95      


Thr Ile Ile Leu Ile Pro Ala Pro Ile Arg Ala Pro Asp Gly Phe Asp 
            100                 105                 110         


Ile Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120                 


<210> 1619
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H1

<400> 1619
Tyr Val Phe Ser Ser Tyr Trp Val Ala 
1               5                   


<210> 1620
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H1

<400> 1620
tacgtcttta gtagttactg ggtcgcc                                           27


<210> 1621
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H2

<400> 1621
Ile Ile Tyr Pro His Asp Ser Asp Thr Arg Tyr Ser Pro Ala Phe Gln 
1               5                   10                  15      


Gly 
    


<210> 1622
<211> 51
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H2

<400> 1622
atcatctatc ctcatgactc tgataccaga tacagcccgg ccttccaagg c                51


<210> 1623
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H3

<400> 1623
Thr Ile Ile Leu Ile Pro Ala Pro Ile Arg Ala Pro Asp Gly Phe Asp 
1               5                   10                  15      


Ile 
    


<210> 1624
<211> 51
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H3

<400> 1624
accattatac taataccagc tcctatacgg gcccctgatg gttttgatat c                51


<210> 1625
<211> 333
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region

<400> 1625
aattttatgc tgactcagcc ccactctgtg tcggagtctc cggggaagac ggtaaccatc       60

tcctgcaccg gcagcggtgg caccattgcc agcaactatg tgcagtggta ccagcagcgc      120

ccgggcagtg tccccaccac tgtgatctat gagaataacg aaagaccctc tggggtccct      180

gatcggttct ctggctccat cgacaggtcc tccaactctg cctccctcac catctctgga      240

ctgaagactg aggacgaggc tgactactac tgtcagtctt atgatagcag ctatcatgtg      300

gtattcggcg gagggaccaa ggtcaccgtc cta                                   333


<210> 1626
<211> 111
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region

<400> 1626
Asn Phe Met Leu Thr Gln Pro His Ser Val Ser Glu Ser Pro Gly Lys 
1               5                   10                  15      


Thr Val Thr Ile Ser Cys Thr Gly Ser Gly Gly Thr Ile Ala Ser Asn 
            20                  25                  30          


Tyr Val Gln Trp Tyr Gln Gln Arg Pro Gly Ser Val Pro Thr Thr Val 
        35                  40                  45              


Ile Tyr Glu Asn Asn Glu Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Ile Asp Arg Ser Ser Asn Ser Ala Ser Leu Thr Ile Ser Gly 
65                  70                  75                  80  


Leu Lys Thr Glu Asp Glu Ala Asp Tyr Tyr Cys Gln Ser Tyr Asp Ser 
                85                  90                  95      


Ser Tyr His Val Val Phe Gly Gly Gly Thr Lys Val Thr Val Leu 
            100                 105                 110     


<210> 1627
<211> 13
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region CDR L1

<400> 1627
Thr Gly Ser Gly Gly Thr Ile Ala Ser Asn Tyr Val Gln 
1               5                   10              


<210> 1628
<211> 39
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region CDR L1

<400> 1628
accggcagcg gtggcaccat tgccagcaac tatgtgcag                              39


<210> 1629
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region CDR L2

<400> 1629
Glu Asn Asn Glu Arg Pro Ser 
1               5           


<210> 1630
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region CDR L2

<400> 1630
gagaataacg aaagaccctc t                                                 21


<210> 1631
<211> 10
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region CDR L3

<400> 1631
Gln Ser Tyr Asp Ser Ser Tyr His Val Val 
1               5                   10  


<210> 1632
<211> 30
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region CDR L3

<400> 1632
cagtcttatg atagcagcta tcatgtggta                                        30


<210> 1633
<211> 369
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region

<400> 1633
caggtgcagc tggtgcagtc tggggctgag gtgaagaagc ctgggtcctc ggtgaaggtc       60

tcctgcaagg cctctggaga cacgttcagc agctatgcta tcagctgggt gcgacaggcc      120

cctggacaag gacttgagtg gatgggaggg gtcctcccta tgttagggac agcaaactac      180

gcacagaggt tccggggcag agtcacactt accgcggacg gatccacgaa cacagcctac      240

atggagatga gcagcctgag acttgacgac acggccgtgt attactgtgc gagagtggcc      300

ggtctgggaa atagctacgg tcgataccct gacctctggg gccagggaac cctggtcacc      360

gtctcctca                                                              369


<210> 1634
<211> 123
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region

<400> 1634
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Asp Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Gly Val Leu Pro Met Leu Gly Thr Ala Asn Tyr Ala Gln Arg Phe 
    50                  55                  60                  


Arg Gly Arg Val Thr Leu Thr Ala Asp Gly Ser Thr Asn Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Met Ser Ser Leu Arg Leu Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Val Ala Gly Leu Gly Asn Ser Tyr Gly Arg Tyr Pro Asp Leu 
            100                 105                 110         


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120             


<210> 1635
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H1

<400> 1635
Asp Thr Phe Ser Ser Tyr Ala Ile Ser 
1               5                   


<210> 1636
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H1

<400> 1636
gacacgttca gcagctatgc tatcagc                                           27


<210> 1637
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H2

<400> 1637
Gly Val Leu Pro Met Leu Gly Thr Ala Asn Tyr Ala Gln Arg Phe Arg 
1               5                   10                  15      


Gly 
    


<210> 1638
<211> 51
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H2

<400> 1638
ggggtcctcc ctatgttagg gacagcaaac tacgcacaga ggttccgggg c                51


<210> 1639
<211> 16
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H3

<400> 1639
Ala Arg Val Ala Gly Leu Gly Asn Ser Tyr Gly Arg Tyr Pro Asp Leu 
1               5                   10                  15      


<210> 1640
<211> 48
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H3

<400> 1640
gcgagagtgg ccggtctggg aaatagctac ggtcgatacc ctgacctc                    48


<210> 1641
<211> 321
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region

<400> 1641
gatattgtga tgacccagtc tccatcttct ctgtctgcat ctgttggaga cagagtcacc       60

atcacttgtc gggcgagtca gggtattagc agctcgttag cctggtatca gcagaaacca      120

gggaaagccc ctgagctcct gatctatgct gcatccagtt tgcacagtgg ggtcccatcg      180

aggttccggg gcagtggatc tgggacagac ttcactctca ctatcagcag cgtgcagcct      240

gaagattttg caacttacta ttgtcaacag gcaaacagtt tcccgtacac ttttggccag      300

gggaccaagc tggagatcaa a                                                321


<210> 1642
<211> 107
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region

<400> 1642
Asp Ile Val Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Ser Ser Ser 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Glu Leu Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Ser Leu His Ser Gly Val Pro Ser Arg Phe Arg Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Val Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ala Asn Ser Phe Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210> 1643
<211> 11
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region CDR L1

<400> 1643
Arg Ala Ser Gln Gly Ile Ser Ser Ser Leu Ala 
1               5                   10      


<210> 1644
<211> 33
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region CDR L1

<400> 1644
cgggcgagtc agggtattag cagctcgtta gcc                                    33


<210> 1645
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region CDR L2

<400> 1645
Ala Ala Ser Ser Leu His Ser 
1               5           


<210> 1646
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region CDR L2

<400> 1646
gctgcatcca gtttgcacag t                                                 21


<210> 1647
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region CDR L3

<400> 1647
Gln Gln Ala Asn Ser Phe Pro Tyr Thr 
1               5                   


<210> 1648
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region CDR L3

<400> 1648
caacaggcaa acagtttccc gtacact                                           27


<210> 1649
<211> 363
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region

<400> 1649
caggtccagc ttgtacagtc tggagcagag gtgaaaaagc cgggggagtc tctgaagatc       60

tcctgtaagg gtgcaggatt cggctctacc aactcctgga tcggctgggt gcgccagatg      120

cccgggaaag gcctggagtg gatgggggtc atctttccag gtgactctga taccaaatac      180

agcccgacct tccaaggcca ggtcaccatc tcagtcgaca agtccatcaa caccgcctac      240

ctgcagtgga gcagcctgaa ggcctcggac accgccatct attactgtgc gagaatgctg      300

gcttctgttg gtttgtccaa ctttgacgcg tggggccagg gaaccctggt caccgtctcc      360

tca                                                                    363


<210> 1650
<211> 121
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region

<400> 1650
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu 
1               5                   10                  15      


Ser Leu Lys Ile Ser Cys Lys Gly Ala Gly Phe Gly Ser Thr Asn Ser 
            20                  25                  30          


Trp Ile Gly Trp Val Arg Gln Met Pro Gly Lys Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Val Ile Phe Pro Gly Asp Ser Asp Thr Lys Tyr Ser Pro Thr Phe 
    50                  55                  60                  


Gln Gly Gln Val Thr Ile Ser Val Asp Lys Ser Ile Asn Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Trp Ser Ser Leu Lys Ala Ser Asp Thr Ala Ile Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Met Leu Ala Ser Val Gly Leu Ser Asn Phe Asp Ala Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120     


<210> 1651
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H1

<400> 1651
Phe Gly Ser Thr Asn Ser Trp Ile Gly 
1               5                   


<210> 1652
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H1

<400> 1652
ttcggctcta ccaactcctg gatcggc                                           27


<210> 1653
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H2

<400> 1653
Val Ile Phe Pro Gly Asp Ser Asp Thr Lys Tyr Ser Pro Thr Phe Gln 
1               5                   10                  15      


Gly 
    


<210> 1654
<211> 51
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H2

<400> 1654
gtcatctttc caggtgactc tgataccaaa tacagcccga ccttccaagg c                51


<210> 1655
<211> 14
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H3

<400> 1655
Ala Arg Met Leu Ala Ser Val Gly Leu Ser Asn Phe Asp Ala 
1               5                   10                  


<210> 1656
<211> 42
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H3

<400> 1656
gcgagaatgc tggcttctgt tggtttgtcc aactttgacg cg                          42


<210> 1657
<211> 324
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region

<400> 1657
cagcctgtgc tgactcagcc accctcagtg tcactggccc caggaaagac ggccacgatt       60

acctgtgggg gaaacaacat tggaggtaaa agtgtgcact ggtaccagca gaagccaggc      120

caggcccctg tgctggtcat cgattatgat agcgaccggc cctcagggat ccctgagcga      180

ttctctggct ccaactctgg gaacacggcc accctgacca tcaacagggt cgaagccggg      240

gatgaggccg actactactg tcaggtgtgg gatagtatta gtgatcatgt gttattcggt      300

ggagggacca agctgaccgt ccta                                             324


<210> 1658
<211> 108
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region

<400> 1658
Gln Pro Val Leu Thr Gln Pro Pro Ser Val Ser Leu Ala Pro Gly Lys 
1               5                   10                  15      


Thr Ala Thr Ile Thr Cys Gly Gly Asn Asn Ile Gly Gly Lys Ser Val 
            20                  25                  30          


His Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Val Leu Val Ile Asp 
        35                  40                  45              


Tyr Asp Ser Asp Arg Pro Ser Gly Ile Pro Glu Arg Phe Ser Gly Ser 
    50                  55                  60                  


Asn Ser Gly Asn Thr Ala Thr Leu Thr Ile Asn Arg Val Glu Ala Gly 
65                  70                  75                  80  


Asp Glu Ala Asp Tyr Tyr Cys Gln Val Trp Asp Ser Ile Ser Asp His 
                85                  90                  95      


Val Leu Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105             


<210> 1659
<211> 11
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region CDR L1

<400> 1659
Gly Gly Asn Asn Ile Gly Gly Lys Ser Val His 
1               5                   10      


<210> 1660
<211> 33
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region CDR L1

<400> 1660
gggggaaaca acattggagg taaaagtgtg cac                                    33


<210> 1661
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region CDR L2

<400> 1661
Tyr Asp Ser Asp Arg Pro Ser 
1               5           


<210> 1662
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region CDR L2

<400> 1662
tatgatagcg accggccctc a                                                 21


<210> 1663
<211> 11
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region CDR L3

<400> 1663
Gln Val Trp Asp Ser Ile Ser Asp His Val Leu 
1               5                   10      


<210> 1664
<211> 33
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region CDR L3

<400> 1664
caggtgtggg atagtattag tgatcatgtg tta                                    33


<210> 1665
<211> 390
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region

<400> 1665
gaggtgcagc tggtggagtc tgggggaggc ttggttaagc ctggggggtc ccttagactc       60

tcttgtgcag cctctggatt cactttcagt aacgcctgga tgagctgggt ccgccaggct      120

ccagggaagg ggctggagtg ggttggccgt gttaaaagca aatctaaagg tgggacaaca      180

cactacgctg aagccgtgaa gggcagattc accatttcaa gagatgattc aaaaaacacg      240

ctgtacctcc aaatgcagag cctgaaaacc gaggacacag ccgtctatta ctgtacctcc      300

cacgcgtata atagtgactg gttcgtgacg actgactact actactacat ggacgtctgg      360

ggcaaaggga ccacggtcac cgtctcctca                                       390


<210> 1666
<211> 130
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region

<400> 1666
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Ala 
            20                  25                  30          


Trp Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Gly Arg Val Lys Ser Lys Ser Lys Gly Gly Thr Thr His Tyr Ala Glu 
    50                  55                  60                  


Ala Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr 
65                  70                  75                  80  


Leu Tyr Leu Gln Met Gln Ser Leu Lys Thr Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Thr Ser His Ala Tyr Asn Ser Asp Trp Phe Val Thr Thr Asp 
            100                 105                 110         


Tyr Tyr Tyr Tyr Met Asp Val Trp Gly Lys Gly Thr Thr Val Thr Val 
        115                 120                 125             


Ser Ser 
    130 


<210> 1667
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H1

<400> 1667
Phe Thr Phe Ser Asn Ala Trp Met Ser 
1               5                   


<210> 1668
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H1

<400> 1668
ttcactttca gtaacgcctg gatgagc                                           27


<210> 1669
<211> 19
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H2

<400> 1669
Arg Val Lys Ser Lys Ser Lys Gly Gly Thr Thr His Tyr Ala Glu Ala 
1               5                   10                  15      


Val Lys Gly 
            


<210> 1670
<211> 57
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H2

<400> 1670
cgtgttaaaa gcaaatctaa aggtgggaca acacactacg ctgaagccgt gaagggc          57


<210> 1671
<211> 21
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H3

<400> 1671
Thr Ser His Ala Tyr Asn Ser Asp Trp Phe Val Thr Thr Asp Tyr Tyr 
1               5                   10                  15      


Tyr Tyr Met Asp Val 
            20      


<210> 1672
<211> 63
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H3

<400> 1672
acctcccacg cgtataatag tgactggttc gtgacgactg actactacta ctacatggac       60

gtc                                                                     63


<210> 1673
<211> 321
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region

<400> 1673
gatattgtgc tgacccagtc tccatcctcc ctgtctgcat ctgttggaga cagagtcacc       60

ttcacttgcc gggcaagtca gagcattagc aactatttga attggtatca gcagaaacca      120

gggaaagccc ctaaggtcct gatctatggt gcttccaatt tgctaagtgg ggtcccatca      180

aggttcattg gcagcggatc tgggacagat ttcactctca ccatcaacag tctgcaacct      240

gaagattttg caacttacta ctgtcaacag tgttacagtg ccccgatcac cttcggccaa      300

gggacacgac tggagattaa a                                                321


<210> 1674
<211> 107
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region

<400> 1674
Asp Ile Val Leu Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Phe Thr Cys Arg Ala Ser Gln Ser Ile Ser Asn Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Val Leu Ile 
        35                  40                  45              


Tyr Gly Ala Ser Asn Leu Leu Ser Gly Val Pro Ser Arg Phe Ile Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Asn Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Cys Tyr Ser Ala Pro Ile 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Arg Leu Glu Ile Lys 
            100                 105         


<210> 1675
<211> 11
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region CDR L1

<400> 1675
Arg Ala Ser Gln Ser Ile Ser Asn Tyr Leu Asn 
1               5                   10      


<210> 1676
<211> 33
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region CDR L1

<400> 1676
cgggcaagtc agagcattag caactatttg aat                                    33


<210> 1677
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region CDR L2

<400> 1677
Gly Ala Ser Asn Leu Leu Ser 
1               5           


<210> 1678
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region CDR L2

<400> 1678
ggtgcttcca atttgctaag t                                                 21


<210> 1679
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region CDR L3

<400> 1679
Gln Gln Cys Tyr Ser Ala Pro Ile Thr 
1               5                   


<210> 1680
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region CDR L3

<400> 1680
caacagtgtt acagtgcccc gatcacc                                           27


<210> 1681
<211> 390
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region

<400> 1681
caggtccagc tggtgcagtc tggggctgag gtgaagaagc ctgggtcctc ggtgaaggtc       60

tcctgcacgg cctctggagg cagcttcagc accaatagta ttgcctggct gaggcagacc      120

cctagagaag ggctggagtg gatgggagga atcatccctg tctttggtgc agcaaaatac      180

gcacagaagt tccagggcag agtcacgatt agcgcggacg catccacgac cacagcctac      240

ttggagctgc acaacctgag atctgaggac actgccgtct attactgcgc gagaggaatt      300

tcccccagga caaacagtga ctggaaccac aactacttct actactacat ggacgtctgg      360

ggcaaaggga ccacggtcac cgtctcctca                                       390


<210> 1682
<211> 130
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region

<400> 1682
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Thr Ala Ser Gly Gly Ser Phe Ser Thr Asn 
            20                  25                  30          


Ser Ile Ala Trp Leu Arg Gln Thr Pro Arg Glu Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Gly Ile Ile Pro Val Phe Gly Ala Ala Lys Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Ser Ala Asp Ala Ser Thr Thr Thr Ala Tyr 
65                  70                  75                  80  


Leu Glu Leu His Asn Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Ile Ser Pro Arg Thr Asn Ser Asp Trp Asn His Asn Tyr 
            100                 105                 110         


Phe Tyr Tyr Tyr Met Asp Val Trp Gly Lys Gly Thr Thr Val Thr Val 
        115                 120                 125             


Ser Ser 
    130 


<210> 1683
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H1

<400> 1683
Gly Ser Phe Ser Thr Asn Ser Ile Ala 
1               5                   


<210> 1684
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H1

<400> 1684
ggcagcttca gcaccaatag tattgcc                                           27


<210> 1685
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H2

<400> 1685
Gly Ile Ile Pro Val Phe Gly Ala Ala Lys Tyr Ala Gln Lys Phe Gln 
1               5                   10                  15      


Gly 
    


<210> 1686
<211> 51
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H2

<400> 1686
ggaatcatcc ctgtctttgg tgcagcaaaa tacgcacaga agttccaggg c                51


<210> 1687
<211> 23
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H3

<400> 1687
Ala Arg Gly Ile Ser Pro Arg Thr Asn Ser Asp Trp Asn His Asn Tyr 
1               5                   10                  15      


Phe Tyr Tyr Tyr Met Asp Val 
            20              


<210> 1688
<211> 69
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H3

<400> 1688
gcgagaggaa tttcccccag gacaaacagt gactggaacc acaactactt ctactactac       60

atggacgtc                                                               69


<210> 1689
<211> 324
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region

<400> 1689
gaaacgacac tcacgcagtc tccaggcacc ctgtctttgt ctccagggga gagagccacc       60

ctctcctgcc gggccagtca gagtattttc accatctact tagcctggta ccagcagaaa      120

cctggccagg ctcccagact cctcatctat agtgcatcca acagggccac tggcatccca      180

gacaggttca gtggcagtgg gtctgggaca gacttcactc tcaccatcag cagcctggag      240

cctgaagatt ttgcagtcta ttactgccac cactatggta cctcacctca cacttttggc      300

caggggacac gactggagat taaa                                             324


<210> 1690
<211> 108
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region

<400> 1690
Glu Thr Thr Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Ile Phe Thr Ile 
            20                  25                  30          


Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu 
        35                  40                  45              


Ile Tyr Ser Ala Ser Asn Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu 
65                  70                  75                  80  


Pro Glu Asp Phe Ala Val Tyr Tyr Cys His His Tyr Gly Thr Ser Pro 
                85                  90                  95      


His Thr Phe Gly Gln Gly Thr Arg Leu Glu Ile Lys 
            100                 105             


<210> 1691
<211> 12
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region CDR L1

<400> 1691
Arg Ala Ser Gln Ser Ile Phe Thr Ile Tyr Leu Ala 
1               5                   10          


<210> 1692
<211> 36
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region CDR L1

<400> 1692
cgggccagtc agagtatttt caccatctac ttagcc                                 36


<210> 1693
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region CDR L2

<400> 1693
Ser Ala Ser Asn Arg Ala Thr 
1               5           


<210> 1694
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region CDR L2

<400> 1694
agtgcatcca acagggccac t                                                 21


<210> 1695
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region CDR L3

<400> 1695
His His Tyr Gly Thr Ser Pro His Thr 
1               5                   


<210> 1696
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region CDR L3

<400> 1696
caccactatg gtacctcacc tcacact                                           27


<210> 1697
<211> 360
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region

<400> 1697
gaggtgcagc tgttggagtc tggtcctgtg ctggtgaaac ccacagagac cctcacgctg       60

acctgcaccg tctctgggtt ctcactcgcc aatcctgacg tggctgtggc ctggatccgt      120

cagccccccg ggaaggccct ggagtggctt gcacacattt tttcgggcga cgaaacatcc      180

tacaccacat ctctgcagaa cagactcacc atctccaagg acacctccaa aagccaggtt      240

gtccttatca tgaccaagat ggaccctcga gacaccggca catatttctg tgcacgggtg      300

ttgactacct ggcacggacc ggactactgg ggccagggga ccacggtcac cgtctcctca      360


<210> 1698
<211> 120
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region

<400> 1698
Glu Val Gln Leu Leu Glu Ser Gly Pro Val Leu Val Lys Pro Thr Glu 
1               5                   10                  15      


Thr Leu Thr Leu Thr Cys Thr Val Ser Gly Phe Ser Leu Ala Asn Pro 
            20                  25                  30          


Asp Val Ala Val Ala Trp Ile Arg Gln Pro Pro Gly Lys Ala Leu Glu 
        35                  40                  45              


Trp Leu Ala His Ile Phe Ser Gly Asp Glu Thr Ser Tyr Thr Thr Ser 
    50                  55                  60                  


Leu Gln Asn Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Ser Gln Val 
65                  70                  75                  80  


Val Leu Ile Met Thr Lys Met Asp Pro Arg Asp Thr Gly Thr Tyr Phe 
                85                  90                  95      


Cys Ala Arg Val Leu Thr Thr Trp His Gly Pro Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Thr Val Thr Val Ser Ser 
        115                 120 


<210> 1699
<211> 11
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H1

<400> 1699
Phe Ser Leu Ala Asn Pro Asp Val Ala Val Ala 
1               5                   10      


<210> 1700
<211> 33
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H1

<400> 1700
ttctcactcg ccaatcctga cgtggctgtg gcc                                    33


<210> 1701
<211> 16
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H2

<400> 1701
His Ile Phe Ser Gly Asp Glu Thr Ser Tyr Thr Thr Ser Leu Gln Asn 
1               5                   10                  15      


<210> 1702
<211> 48
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H2

<400> 1702
cacatttttt cgggcgacga aacatcctac accacatctc tgcagaac                    48


<210> 1703
<211> 12
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H3

<400> 1703
Ala Arg Val Leu Thr Thr Trp His Gly Pro Asp Tyr 
1               5                   10          


<210> 1704
<211> 36
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H3

<400> 1704
gcacgggtgt tgactacctg gcacggaccg gactac                                 36


<210> 1705
<211> 336
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region

<400> 1705
gaaacgacac tcacgcagtc tccactctcc ctgcccgtca cccttggaca gccggcctcc       60

atctcctgca ggtctgatca aagcctcgta tatcataatg gaaacaccta cgtgagttgg      120

tttcatcaga ggccaggcca atctccaagg cgcctaattt ataaggtttc tatccgggac      180

tctggggtcc cagacagatt cagcggcagt gggtcaggca ctgatttcgc actgaaaatc      240

agcagggtgg aggctgagga tcttggggtt tattactgca tgcaaggttc acactggccg      300

cacacttttg gccaggggac caaagtggat atcaaa                                336


<210> 1706
<211> 112
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region

<400> 1706
Glu Thr Thr Leu Thr Gln Ser Pro Leu Ser Leu Pro Val Thr Leu Gly 
1               5                   10                  15      


Gln Pro Ala Ser Ile Ser Cys Arg Ser Asp Gln Ser Leu Val Tyr His 
            20                  25                  30          


Asn Gly Asn Thr Tyr Val Ser Trp Phe His Gln Arg Pro Gly Gln Ser 
        35                  40                  45              


Pro Arg Arg Leu Ile Tyr Lys Val Ser Ile Arg Asp Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Ala Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Leu Gly Val Tyr Tyr Cys Met Gln Gly 
                85                  90                  95      


Ser His Trp Pro His Thr Phe Gly Gln Gly Thr Lys Val Asp Ile Lys 
            100                 105                 110         


<210> 1707
<211> 16
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region CDR L1

<400> 1707
Arg Ser Asp Gln Ser Leu Val Tyr His Asn Gly Asn Thr Tyr Val Ser 
1               5                   10                  15      


<210> 1708
<211> 48
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region CDR L1

<400> 1708
aggtctgatc aaagcctcgt atatcataat ggaaacacct acgtgagt                    48


<210> 1709
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region CDR L2

<400> 1709
Lys Val Ser Ile Arg Asp Ser 
1               5           


<210> 1710
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region CDR L2

<400> 1710
aaggtttcta tccgggactc t                                                 21


<210> 1711
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region CDR L3

<400> 1711
Met Gln Gly Ser His Trp Pro His Thr 
1               5                   


<210> 1712
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region CDR L3

<400> 1712
atgcaaggtt cacactggcc gcacact                                           27


<210> 1713
<211> 366
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region

<400> 1713
gaggtgcagc tggtggagtc tgggggaggc ttggtccagc ctggggggtc cctgagactc       60

tcctgtgcag cctctggatt ctcgtttagt acctcttgga tgagttgggt ccgccaggct      120

ccagggaaag gtctggagtg gctggccaac ataaaggaag atggaagtaa gaaaatctat      180

gtggactctg tgaagggccg cttctccata tccagggaca acgccaagaa ctcactgtat      240

ctgcaaatga ccagcctaag agccgaggac acggccgtgt attattgtgc gagagatgtg      300

tgggggtggg agctagtcgg atggttggac ccctggggcc agggaaccct ggtcaccgtc      360

tcctca                                                                 366


<210> 1714
<211> 122
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region

<400> 1714
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ser Phe Ser Thr Ser 
            20                  25                  30          


Trp Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Leu 
        35                  40                  45              


Ala Asn Ile Lys Glu Asp Gly Ser Lys Lys Ile Tyr Val Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Ser Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Thr Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Val Trp Gly Trp Glu Leu Val Gly Trp Leu Asp Pro Trp 
            100                 105                 110         


Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120         


<210> 1715
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H1

<400> 1715
Phe Ser Phe Ser Thr Ser Trp Met Ser 
1               5                   


<210> 1716
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H1

<400> 1716
ttctcgttta gtacctcttg gatgagt                                           27


<210> 1717
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H2

<400> 1717
Asn Ile Lys Glu Asp Gly Ser Lys Lys Ile Tyr Val Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210> 1718
<211> 51
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H2

<400> 1718
aacataaagg aagatggaag taagaaaatc tatgtggact ctgtgaaggg c                51


<210> 1719
<211> 15
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H3

<400> 1719
Ala Arg Asp Val Trp Gly Trp Glu Leu Val Gly Trp Leu Asp Pro 
1               5                   10                  15  


<210> 1720
<211> 45
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H3

<400> 1720
gcgagagatg tgtgggggtg ggagctagtc ggatggttgg acccc                       45


<210> 1721
<211> 324
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region

<400> 1721
tcctatgagc tgacacagcc accctcggta tcagtggccc caggaaagac ggccagcatt       60

acctgtgggg gaagcaacat tggaagtaga agtgtgcact ggtaccagca gaagccaggc      120

caggcccctg tgctggtcgt ctatgaggat cacgaccggc cctcagggat ccctgagcga      180

ttctctggct ccaactctgg gaatacggcc accctgacca tcagcagggt cgaagccggg      240

gacgaggccg actattactg tcaggtgtgg gatagtagta gagatcatgt ggtattcggc      300

ggcgggacca aggtcaccgt ccta                                             324


<210> 1722
<211> 108
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region

<400> 1722
Ser Tyr Glu Leu Thr Gln Pro Pro Ser Val Ser Val Ala Pro Gly Lys 
1               5                   10                  15      


Thr Ala Ser Ile Thr Cys Gly Gly Ser Asn Ile Gly Ser Arg Ser Val 
            20                  25                  30          


His Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Val Leu Val Val Tyr 
        35                  40                  45              


Glu Asp His Asp Arg Pro Ser Gly Ile Pro Glu Arg Phe Ser Gly Ser 
    50                  55                  60                  


Asn Ser Gly Asn Thr Ala Thr Leu Thr Ile Ser Arg Val Glu Ala Gly 
65                  70                  75                  80  


Asp Glu Ala Asp Tyr Tyr Cys Gln Val Trp Asp Ser Ser Arg Asp His 
                85                  90                  95      


Val Val Phe Gly Gly Gly Thr Lys Val Thr Val Leu 
            100                 105             


<210> 1723
<211> 11
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region CDR L1

<400> 1723
Gly Gly Ser Asn Ile Gly Ser Arg Ser Val His 
1               5                   10      


<210> 1724
<211> 33
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region CDR L1

<400> 1724
gggggaagca acattggaag tagaagtgtg cac                                    33


<210> 1725
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region CDR L2

<400> 1725
Glu Asp His Asp Arg Pro Ser 
1               5           


<210> 1726
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region CDR L2

<400> 1726
gaggatcacg accggccctc a                                                 21


<210> 1727
<211> 11
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region CDR L3

<400> 1727
Gln Val Trp Asp Ser Ser Arg Asp His Val Val 
1               5                   10      


<210> 1728
<211> 33
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region CDR L3

<400> 1728
caggtgtggg atagtagtag agatcatgtg gta                                    33


<210> 1729
<211> 378
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region

<400> 1729
gaggtgcagc tggtggagtc tggtcctgcg ctggtgaaac ccacacagac cctcacactg       60

acctgcacct tctctgggtt ctcactcagc agtagaagaa tgtgtgtgag ttggatccgt      120

cagcccccag ggaaggccct ggagtggctt gcacgcattg attgggatga tgataaatcc      180

tacagcacat ctctgaagac caggctcacc atcgccaagg acacctccaa aaaccaggtc      240

gtccttacaa tgaccaacat gggccccgcg gacacagcca cgtattactg tgcacggact      300

cctatatatg atagtagtgg ttattacctc tactactttg actcctgggg ccagggaacc      360

ctggtcaccg tctcctca                                                    378


<210> 1730
<211> 126
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region

<400> 1730
Glu Val Gln Leu Val Glu Ser Gly Pro Ala Leu Val Lys Pro Thr Gln 
1               5                   10                  15      


Thr Leu Thr Leu Thr Cys Thr Phe Ser Gly Phe Ser Leu Ser Ser Arg 
            20                  25                  30          


Arg Met Cys Val Ser Trp Ile Arg Gln Pro Pro Gly Lys Ala Leu Glu 
        35                  40                  45              


Trp Leu Ala Arg Ile Asp Trp Asp Asp Asp Lys Ser Tyr Ser Thr Ser 
    50                  55                  60                  


Leu Lys Thr Arg Leu Thr Ile Ala Lys Asp Thr Ser Lys Asn Gln Val 
65                  70                  75                  80  


Val Leu Thr Met Thr Asn Met Gly Pro Ala Asp Thr Ala Thr Tyr Tyr 
                85                  90                  95      


Cys Ala Arg Thr Pro Ile Tyr Asp Ser Ser Gly Tyr Tyr Leu Tyr Tyr 
            100                 105                 110         


Phe Asp Ser Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125     


<210> 1731
<211> 11
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H1

<400> 1731
Phe Ser Leu Ser Ser Arg Arg Met Cys Val Ser 
1               5                   10      


<210> 1732
<211> 33
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H1

<400> 1732
ttctcactca gcagtagaag aatgtgtgtg agt                                    33


<210> 1733
<211> 16
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H2

<400> 1733
Arg Ile Asp Trp Asp Asp Asp Lys Ser Tyr Ser Thr Ser Leu Lys Thr 
1               5                   10                  15      


<210> 1734
<211> 48
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H2

<400> 1734
cgcattgatt gggatgatga taaatcctac agcacatctc tgaagacc                    48


<210> 1735
<211> 18
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H3

<400> 1735
Ala Arg Thr Pro Ile Tyr Asp Ser Ser Gly Tyr Tyr Leu Tyr Tyr Phe 
1               5                   10                  15      


Asp Ser 
        


<210> 1736
<211> 54
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H3

<400> 1736
gcacggactc ctatatatga tagtagtggt tattacctct actactttga ctcc             54


<210> 1737
<211> 321
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region

<400> 1737
gaaacgacac tcacgcagtc tccatcctcc ctgtctgcat ctgtcggaga cagagtcacc       60

atcacttgcc gggcaagtca gagcattagc agctatttaa attggtatca gcagaaacca      120

gggaaagccc ctaagctcct gatctatgct gcatccagtt tgcaaagtgg ggtcccatca      180

aggttcagtg gcagtggatc tgggacagat ttcactctca ccatcagcag tctgcaacct      240

gaagattttg caacttacta ctgtcaacag agttacagta cccctgtgac ttttggccag      300

gggaccaagg tggagatcaa a                                                321


<210> 1738
<211> 107
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region

<400> 1738
Glu Thr Thr Leu Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Tyr Ser Thr Pro Val 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210> 1739
<211> 11
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region CDR L1

<400> 1739
Arg Ala Ser Gln Ser Ile Ser Ser Tyr Leu Asn 
1               5                   10      


<210> 1740
<211> 33
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region CDR L1

<400> 1740
cgggcaagtc agagcattag cagctattta aat                                    33


<210> 1741
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region CDR L2

<400> 1741
Ala Ala Ser Ser Leu Gln Ser 
1               5           


<210> 1742
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region CDR L2

<400> 1742
gctgcatcca gtttgcaaag t                                                 21


<210> 1743
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region CDR L3

<400> 1743
Gln Gln Ser Tyr Ser Thr Pro Val Thr 
1               5                   


<210> 1744
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region CDR L3

<400> 1744
caacagagtt acagtacccc tgtgact                                           27


<210> 1745
<211> 372
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region

<400> 1745
caggtccagc ttgtgcagtc tgggggaggc gtggtccagc ctgggaggtc cctgagactc       60

tcctgtgcag cctctggatt caccttcagt gactatgcta tgcactgggt ccgccaggct      120

ccaggcaagg gcctccagtg ggtgtcactt atatcatata atggacgtaa aaaatattac      180

gcagactccg tgaagggccg attcaccatc tccagagacg attccaagaa cacgctgtat      240

ctgcaaatga accccctgag acctgacgac acggctgtct attactgtgc gagagatggg      300

gatattgtag ctgttccagc tgctatcggg ttggactact ggggccaggg aaccctggtc      360

accgtctcct ca                                                          372


<210> 1746
<211> 124
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region

<400> 1746
Gln Val Gln Leu Val Gln Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp Tyr 
            20                  25                  30          


Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Gln Trp Val 
        35                  40                  45              


Ser Leu Ile Ser Tyr Asn Gly Arg Lys Lys Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Pro Leu Arg Pro Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Gly Asp Ile Val Ala Val Pro Ala Ala Ile Gly Leu Asp 
            100                 105                 110         


Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 


<210> 1747
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H1

<400> 1747
Phe Thr Phe Ser Asp Tyr Ala Met His 
1               5                   


<210> 1748
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H1

<400> 1748
ttcaccttca gtgactatgc tatgcac                                           27


<210> 1749
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H2

<400> 1749
Leu Ile Ser Tyr Asn Gly Arg Lys Lys Tyr Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210> 1750
<211> 51
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H2

<400> 1750
cttatatcat ataatggacg taaaaaatat tacgcagact ccgtgaaggg c                51


<210> 1751
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H3

<400> 1751
Ala Arg Asp Gly Asp Ile Val Ala Val Pro Ala Ala Ile Gly Leu Asp 
1               5                   10                  15      


Tyr 
    


<210> 1752
<211> 51
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H3

<400> 1752
gcgagagatg gggatattgt agctgttcca gctgctatcg ggttggacta c                51


<210> 1753
<211> 339
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region

<400> 1753
gatattgtgc tgacccagtc tccagagtcc ctggctgtgt ctctgggcga gagggccacc       60

atcaactgca actccagcca gagtgtttta tacacctcca acaacaagaa ctacttagct      120

tggtaccagc agaaatcagg acagcctcct aagctgctca tttactgggc atctacccgg      180

gaatccgggg tccctgagcg attcagtggc agcgggtctg ggacagattt cactctcacc      240

atcagcagcc tgcaggctga agatgtggca gtttattact gtcagcaata ttctagtcct      300

ccgtacactt ttggccaggg gaccaagctg gagatcaaa                             339


<210> 1754
<211> 113
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region

<400> 1754
Asp Ile Val Leu Thr Gln Ser Pro Glu Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Glu Arg Ala Thr Ile Asn Cys Asn Ser Ser Gln Ser Val Leu Tyr Thr 
            20                  25                  30          


Ser Asn Asn Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Ser Gly Gln 
        35                  40                  45              


Pro Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Glu Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Leu Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys Gln Gln 
                85                  90                  95      


Tyr Ser Ser Pro Pro Tyr Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile 
            100                 105                 110         


Lys 
    


<210> 1755
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region CDR L1

<400> 1755
Asn Ser Ser Gln Ser Val Leu Tyr Thr Ser Asn Asn Lys Asn Tyr Leu 
1               5                   10                  15      


Ala 
    


<210> 1756
<211> 51
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region CDR L1

<400> 1756
aactccagcc agagtgtttt atacacctcc aacaacaaga actacttagc t                51


<210> 1757
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region CDR L2

<400> 1757
Trp Ala Ser Thr Arg Glu Ser 
1               5           


<210> 1758
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region CDR L2

<400> 1758
tgggcatcta cccgggaatc c                                                 21


<210> 1759
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region CDR L3

<400> 1759
Gln Gln Tyr Ser Ser Pro Pro Tyr Thr 
1               5                   


<210> 1760
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region CDR L3

<400> 1760
cagcaatatt ctagtcctcc gtacact                                           27


<210> 1761
<211> 366
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region

<400> 1761
caggtgcagc tgcaggagtc cggcccagga ctagtgaagc cttcagagac cctgtccctc       60

acttgcagtg tctctggtgg ctccatcaaa agaggtgctt acttctggac ctggatccgc      120

cagcggccag ggaagggcct ggagtggatt gggtccatgc atgacagcgg cgactactac      180

aacccgtccc tcaagacacg cgttaccatt ttgggagaca cgactaagaa ccacttcacc      240

ctgaagttga cctccgtgac tgtcgcggac acggccttat attactgtgc gagggggcgc      300

ggatacagct atggctggcg tttctttgac aactggggcc agggaaccct ggtcaccgtc      360

tcctca                                                                 366


<210> 1762
<211> 122
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region

<400> 1762
Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Ser Val Ser Gly Gly Ser Ile Lys Arg Gly 
            20                  25                  30          


Ala Tyr Phe Trp Thr Trp Ile Arg Gln Arg Pro Gly Lys Gly Leu Glu 
        35                  40                  45              


Trp Ile Gly Ser Met His Asp Ser Gly Asp Tyr Tyr Asn Pro Ser Leu 
    50                  55                  60                  


Lys Thr Arg Val Thr Ile Leu Gly Asp Thr Thr Lys Asn His Phe Thr 
65                  70                  75                  80  


Leu Lys Leu Thr Ser Val Thr Val Ala Asp Thr Ala Leu Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Arg Gly Tyr Ser Tyr Gly Trp Arg Phe Phe Asp Asn Trp 
            100                 105                 110         


Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120         


<210> 1763
<211> 11
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H1

<400> 1763
Gly Ser Ile Lys Arg Gly Ala Tyr Phe Trp Thr 
1               5                   10      


<210> 1764
<211> 33
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H1

<400> 1764
ggctccatca aaagaggtgc ttacttctgg acc                                    33


<210> 1765
<211> 15
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H2

<400> 1765
Ser Met His Asp Ser Gly Asp Tyr Tyr Asn Pro Ser Leu Lys Thr 
1               5                   10                  15  


<210> 1766
<211> 45
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H2

<400> 1766
tccatgcatg acagcggcga ctactacaac ccgtccctca agaca                       45


<210> 1767
<211> 15
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H3

<400> 1767
Ala Arg Gly Arg Gly Tyr Ser Tyr Gly Trp Arg Phe Phe Asp Asn 
1               5                   10                  15  


<210> 1768
<211> 45
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H3

<400> 1768
gcgagggggc gcggatacag ctatggctgg cgtttctttg acaac                       45


<210> 1769
<211> 324
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region

<400> 1769
aattttatgc tgactcagcc cccctcggtg tcagtgtccc caggacactc gaccaggatc       60

acctgctctg gagatgcttt gccaaagcaa tatgcttatt ggtatcagca gaagccaggc      120

caggcccctg tcctgataat gtccaaagac agtgagaggc cctcagggat ccctgagcga      180

ttcactggct ccagctcagg gactacagtc actttgacca tcagtggagt ccaggcagag      240

gacgaggccg actattactg tcaatcagga gacaccagtg gaagttatgt cgtcttcggc      300

ggagggacca aggtcaccgt ccta                                             324


<210> 1770
<211> 108
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region

<400> 1770
Asn Phe Met Leu Thr Gln Pro Pro Ser Val Ser Val Ser Pro Gly His 
1               5                   10                  15      


Ser Thr Arg Ile Thr Cys Ser Gly Asp Ala Leu Pro Lys Gln Tyr Ala 
            20                  25                  30          


Tyr Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Val Leu Ile Met Ser 
        35                  40                  45              


Lys Asp Ser Glu Arg Pro Ser Gly Ile Pro Glu Arg Phe Thr Gly Ser 
    50                  55                  60                  


Ser Ser Gly Thr Thr Val Thr Leu Thr Ile Ser Gly Val Gln Ala Glu 
65                  70                  75                  80  


Asp Glu Ala Asp Tyr Tyr Cys Gln Ser Gly Asp Thr Ser Gly Ser Tyr 
                85                  90                  95      


Val Val Phe Gly Gly Gly Thr Lys Val Thr Val Leu 
            100                 105             


<210> 1771
<211> 11
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region CDR L1

<400> 1771
Ser Gly Asp Ala Leu Pro Lys Gln Tyr Ala Tyr 
1               5                   10      


<210> 1772
<211> 33
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region CDR L1

<400> 1772
tctggagatg ctttgccaaa gcaatatgct tat                                    33


<210> 1773
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region CDR L2

<400> 1773
Lys Asp Ser Glu Arg Pro Ser 
1               5           


<210> 1774
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region CDR L2

<400> 1774
aaagacagtg agaggccctc a                                                 21


<210> 1775
<211> 11
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region CDR L3

<400> 1775
Gln Ser Gly Asp Thr Ser Gly Ser Tyr Val Val 
1               5                   10      


<210> 1776
<211> 33
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region CDR L3

<400> 1776
caatcaggag acaccagtgg aagttatgtc gtc                                    33


<210> 1777
<211> 390
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region

<400> 1777
gaggtgcagc tgttggagtc cgggccagag ttgaagaagc ctgggtcctc ggtgaaggtg       60

tcttgcaagg cctctgcaga cactttcaat ggtcactcaa ttgcttgggt gcggcaggcc      120

cctggacaag ggcttgagtg ggtgggagga ttcatcccca tttttgggaa agcatactac      180

gcacagaact tccagggcac agtcacgatt tccgcggatt cttccacgag aacagtctac      240

atggatctgt tcaacctgag atctgaggac acggccgtct attactgtgc gagatcaagg      300

aaaaatgtta tcggggacac cagtgcctgg gaacatatgt acttctacat ggacgtctgg      360

ggcaccggga ccacggtcac cgtctcctca                                       390


<210> 1778
<211> 130
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region

<400> 1778
Glu Val Gln Leu Leu Glu Ser Gly Pro Glu Leu Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Ala Asp Thr Phe Asn Gly His 
            20                  25                  30          


Ser Ile Ala Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Val 
        35                  40                  45              


Gly Gly Phe Ile Pro Ile Phe Gly Lys Ala Tyr Tyr Ala Gln Asn Phe 
    50                  55                  60                  


Gln Gly Thr Val Thr Ile Ser Ala Asp Ser Ser Thr Arg Thr Val Tyr 
65                  70                  75                  80  


Met Asp Leu Phe Asn Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ser Arg Lys Asn Val Ile Gly Asp Thr Ser Ala Trp Glu His 
            100                 105                 110         


Met Tyr Phe Tyr Met Asp Val Trp Gly Thr Gly Thr Thr Val Thr Val 
        115                 120                 125             


Ser Ser 
    130 


<210> 1779
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H1

<400> 1779
Asp Thr Phe Asn Gly His Ser Ile Ala 
1               5                   


<210> 1780
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H1

<400> 1780
gacactttca atggtcactc aattgct                                           27


<210> 1781
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H2

<400> 1781
Gly Phe Ile Pro Ile Phe Gly Lys Ala Tyr Tyr Ala Gln Asn Phe Gln 
1               5                   10                  15      


Gly 
    


<210> 1782
<211> 51
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H2

<400> 1782
ggattcatcc ccatttttgg gaaagcatac tacgcacaga acttccaggg c                51


<210> 1783
<211> 23
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H3

<400> 1783
Ala Arg Ser Arg Lys Asn Val Ile Gly Asp Thr Ser Ala Trp Glu His 
1               5                   10                  15      


Met Tyr Phe Tyr Met Asp Val 
            20              


<210> 1784
<211> 69
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H3

<400> 1784
gcgagatcaa ggaaaaatgt tatcggggac accagtgcct gggaacatat gtacttctac       60

atggacgtc                                                               69


<210> 1785
<211> 324
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region

<400> 1785
gaaattgtat tgacgcagtc tccaggcacc ctgtctttgt ctccagggga aagagtcact       60

ctctcctgca gggccagtga gagtattaat aagaatacct acttagcctg gtaccaacag      120

aaacctggcc aggctcccag gctcctcatt tatggagcat ccagcagggc cactggcatc      180

ccagacaggt tcagtggcag tgggtctggg acagacttca ctctcaccat cagcagactg      240

gagcctgaag attctgctgt gtattactgt cagcaatatg gtaggtcaat gactttcggc      300

ggagggacca aggtggaaat caaa                                             324


<210> 1786
<211> 108
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region

<400> 1786
Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Val Thr Leu Ser Cys Arg Ala Ser Glu Ser Ile Asn Lys Asn 
            20                  25                  30          


Thr Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu 
        35                  40                  45              


Leu Ile Tyr Gly Ala Ser Ser Arg Ala Thr Gly Ile Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu 
65                  70                  75                  80  


Glu Pro Glu Asp Ser Ala Val Tyr Tyr Cys Gln Gln Tyr Gly Arg Ser 
                85                  90                  95      


Met Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105             


<210> 1787
<211> 13
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region CDR L1

<400> 1787
Arg Ala Ser Glu Ser Ile Asn Lys Asn Thr Tyr Leu Ala 
1               5                   10              


<210> 1788
<211> 39
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region CDR L1

<400> 1788
agggccagtg agagtattaa taagaatacc tacttagcc                              39


<210> 1789
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region CDR L2

<400> 1789
Gly Ala Ser Ser Arg Ala Thr 
1               5           


<210> 1790
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region CDR L2

<400> 1790
ggagcatcca gcagggccac t                                                 21


<210> 1791
<211> 8
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region CDR L3

<400> 1791
Gln Gln Tyr Gly Arg Ser Met Thr 
1               5               


<210> 1792
<211> 24
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region CDR L3

<400> 1792
cagcaatatg gtaggtcaat gact                                              24


<210> 1793
<211> 393
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region

<400> 1793
caggtccagc ttgtacagtc tgggactgag gtgaagaagc ctgggtcctc ggtgaatgtc       60

tcctgcaagg ctgttggagg caagttcacc agttataata ttaactgggt gcgacaggcc      120

cctggacaag gccttgagtg gatgggaagg atcatcccaa cccttggtat aacatacttc      180

gcacagaagt tccagggcag actcacgatt aacgcggaca gatccacgag caccgcctac      240

atggatctga gcagcctgag atctgacgat acggccgttt attattgtgc gagatccaat      300

cccgttgctc gcgatttttg gagtggatat tctgacgact cctcctatgc tatggacgtc      360

tggggccaag ggaccacggt caccgtctcc tca                                   393


<210> 1794
<211> 131
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region

<400> 1794
Gln Val Gln Leu Val Gln Ser Gly Thr Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Asn Val Ser Cys Lys Ala Val Gly Gly Lys Phe Thr Ser Tyr 
            20                  25                  30          


Asn Ile Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Arg Ile Ile Pro Thr Leu Gly Ile Thr Tyr Phe Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Leu Thr Ile Asn Ala Asp Arg Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Asp Leu Ser Ser Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ser Asn Pro Val Ala Arg Asp Phe Trp Ser Gly Tyr Ser Asp 
            100                 105                 110         


Asp Ser Ser Tyr Ala Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr 
        115                 120                 125             


Val Ser Ser 
    130     


<210> 1795
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H1

<400> 1795
Gly Lys Phe Thr Ser Tyr Asn Ile Asn 
1               5                   


<210> 1796
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H1

<400> 1796
ggcaagttca ccagttataa tattaac                                           27


<210> 1797
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H2

<400> 1797
Arg Ile Ile Pro Thr Leu Gly Ile Thr Tyr Phe Ala Gln Lys Phe Gln 
1               5                   10                  15      


Gly 
    


<210> 1798
<211> 51
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H2

<400> 1798
aggatcatcc caacccttgg tataacatac ttcgcacaga agttccaggg c                51


<210> 1799
<211> 24
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H3

<400> 1799
Ala Arg Ser Asn Pro Val Ala Arg Asp Phe Trp Ser Gly Tyr Ser Asp 
1               5                   10                  15      


Asp Ser Ser Tyr Ala Met Asp Val 
            20                  


<210> 1800
<211> 72
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H3

<400> 1800
gcgagatcca atcccgttgc tcgcgatttt tggagtggat attctgacga ctcctcctat       60

gctatggacg tc                                                           72


<210> 1801
<211> 324
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region

<400> 1801
gaaacgacac tcacgcagtc tccaggaacc ctgtctttgt ctccagggga cagagtcagc       60

ctctcctgca gggccagtca gactgttgac aagaactacg tagcctggta ccagcagaag      120

cctggccagg ctcccaggct cctcatctat ggtgcatcca agagggccgc tgacatccca      180

gacaggttca gtggcagtgg ctctggggca gacttcactc tcaccatcag cagactggag      240

cctgaagatt ttgctgtgta tcactgtcag cagtatggag cttcagcgtt cagtttcggc      300

ggcgggacca agctggagat caaa                                             324


<210> 1802
<211> 108
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region

<400> 1802
Glu Thr Thr Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Asp Arg Val Ser Leu Ser Cys Arg Ala Ser Gln Thr Val Asp Lys Asn 
            20                  25                  30          


Tyr Val Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu 
        35                  40                  45              


Ile Tyr Gly Ala Ser Lys Arg Ala Ala Asp Ile Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Ala Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu 
65                  70                  75                  80  


Pro Glu Asp Phe Ala Val Tyr His Cys Gln Gln Tyr Gly Ala Ser Ala 
                85                  90                  95      


Phe Ser Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105             


<210> 1803
<211> 12
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region CDR L1

<400> 1803
Arg Ala Ser Gln Thr Val Asp Lys Asn Tyr Val Ala 
1               5                   10          


<210> 1804
<211> 36
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region CDR L1

<400> 1804
agggccagtc agactgttga caagaactac gtagcc                                 36


<210> 1805
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region CDR L2

<400> 1805
Gly Ala Ser Lys Arg Ala Ala 
1               5           


<210> 1806
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region CDR L2

<400> 1806
ggtgcatcca agagggccgc t                                                 21


<210> 1807
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region CDR L3

<400> 1807
Gln Gln Tyr Gly Ala Ser Ala Phe Ser 
1               5                   


<210> 1808
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region CDR L3

<400> 1808
cagcagtatg gagcttcagc gttcagt                                           27


<210> 1809
<211> 384
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region

<400> 1809
caggtgcagc tggtgcaatc tgggggaggc ttggtaaagc cgggggggtc ccttagactc       60

tcatgtgcag cctctggatt cgctttcagt aacgcctgga tgagctgggt ccgccaggct      120

ccagggaagg ggctggagtg gcttggccgt attaaaagcg aaactgacgg tgggacaaca      180

gactacgctg cacccgtgaa aggcagattc agcatctcaa gagatgattc cagaaacacg      240

ctgtatctgc aaatgaacag cctggaaagc gaggacacag ccgtttatta ctgtaccaca      300

ggcccaccct ataagtattt tgatagtact ggttattcgg tcgttgacta ctggggccag      360

ggaaccctgg tcaccgtctc ctca                                             384


<210> 1810
<211> 128
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region

<400> 1810
Gln Val Gln Leu Val Gln Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ala Phe Ser Asn Ala 
            20                  25                  30          


Trp Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Leu 
        35                  40                  45              


Gly Arg Ile Lys Ser Glu Thr Asp Gly Gly Thr Thr Asp Tyr Ala Ala 
    50                  55                  60                  


Pro Val Lys Gly Arg Phe Ser Ile Ser Arg Asp Asp Ser Arg Asn Thr 
65                  70                  75                  80  


Leu Tyr Leu Gln Met Asn Ser Leu Glu Ser Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Thr Thr Gly Pro Pro Tyr Lys Tyr Phe Asp Ser Thr Gly Tyr 
            100                 105                 110         


Ser Val Val Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125             


<210> 1811
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H1

<400> 1811
Phe Ala Phe Ser Asn Ala Trp Met Ser 
1               5                   


<210> 1812
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H1

<400> 1812
ttcgctttca gtaacgcctg gatgagc                                           27


<210> 1813
<211> 19
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H2

<400> 1813
Arg Ile Lys Ser Glu Thr Asp Gly Gly Thr Thr Asp Tyr Ala Ala Pro 
1               5                   10                  15      


Val Lys Gly 
            


<210> 1814
<211> 57
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H2

<400> 1814
cgtattaaaa gcgaaactga cggtgggaca acagactacg ctgcacccgt gaaaggc          57


<210> 1815
<211> 19
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H3

<400> 1815
Thr Thr Gly Pro Pro Tyr Lys Tyr Phe Asp Ser Thr Gly Tyr Ser Val 
1               5                   10                  15      


Val Asp Tyr 
            


<210> 1816
<211> 57
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H3

<400> 1816
accacaggcc caccctataa gtattttgat agtactggtt attcggtcgt tgactac          57


<210> 1817
<211> 330
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region

<400> 1817
tcctatgagc tgacacagcc accctcagcg tctgggaccc ccgggcagag ggtcaccatc       60

tcttgttctg gaagcagctc caatatcgga agtaattatg tatactggta ccagcagctc      120

ccaggaacgg cccccagact cctcatctat agtactaatc agcggccctc aggggtccct      180

gaccgattct ctggctccca gtctggcacc tcagcctccc tggccatcag tgggctccgg      240

tccgacgatg aggctgatta ttactgtgca gcatgggatg acaggatgag tggtccggtg      300

ttcggcggag ggaccaagct caccgtccta                                       330


<210> 1818
<211> 110
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region

<400> 1818
Ser Tyr Glu Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln 
1               5                   10                  15      


Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn 
            20                  25                  30          


Tyr Val Tyr Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Arg Leu Leu 
        35                  40                  45              


Ile Tyr Ser Thr Asn Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gln Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Arg 
65                  70                  75                  80  


Ser Asp Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Asp Arg Met 
                85                  90                  95      


Ser Gly Pro Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 110 


<210> 1819
<211> 13
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region CDR L1

<400> 1819
Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn Tyr Val Tyr 
1               5                   10              


<210> 1820
<211> 39
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region CDR L1

<400> 1820
tctggaagca gctccaatat cggaagtaat tatgtatac                              39


<210> 1821
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region CDR L2

<400> 1821
Ser Thr Asn Gln Arg Pro Ser 
1               5           


<210> 1822
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region CDR L2

<400> 1822
agtactaatc agcggccctc a                                                 21


<210> 1823
<211> 11
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region CDR L3

<400> 1823
Ala Ala Trp Asp Asp Arg Met Ser Gly Pro Val 
1               5                   10      


<210> 1824
<211> 33
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region CDR L3

<400> 1824
gcagcatggg atgacaggat gagtggtccg gtg                                    33


<210> 1825
<211> 372
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region

<400> 1825
caggtccagc ttgtacagtc tgggggaggc ttggtgcagc ctggggggtc cctaagactc       60

tcctgtgcag cctctggact cacctttagc tcttatgcca tgtcctgggt ccgccaggct      120

ccagggaagg aactggagtg ggtctcatct attagtgaaa gtggtgttga tacatactac      180

gcagactccg tgaagggccg gttcaccgtc tccagagaca attccaaaag cacgctgtat      240

ctgcaaatga gcagcctggg aggcgacgac acggccgtat attattgcgc gaaggcatac      300

tgtagtaata aggcctgcca cgggggctac tttgactact ggggccaggg aaccctggtc      360

accgtctcct ca                                                          372


<210> 1826
<211> 124
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region

<400> 1826
Gln Val Gln Leu Val Gln Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Leu Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Glu Leu Glu Trp Val 
        35                  40                  45              


Ser Ser Ile Ser Glu Ser Gly Val Asp Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Val Ser Arg Asp Asn Ser Lys Ser Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Ser Ser Leu Gly Gly Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Ala Tyr Cys Ser Asn Lys Ala Cys His Gly Gly Tyr Phe Asp 
            100                 105                 110         


Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 


<210> 1827
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H1

<400> 1827
Leu Thr Phe Ser Ser Tyr Ala Met Ser 
1               5                   


<210> 1828
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H1

<400> 1828
ctcaccttta gctcttatgc catgtcc                                           27


<210> 1829
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H2

<400> 1829
Ser Ile Ser Glu Ser Gly Val Asp Thr Tyr Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210> 1830
<211> 51
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H2

<400> 1830
tctattagtg aaagtggtgt tgatacatac tacgcagact ccgtgaaggg c                51


<210> 1831
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H3

<400> 1831
Ala Lys Ala Tyr Cys Ser Asn Lys Ala Cys His Gly Gly Tyr Phe Asp 
1               5                   10                  15      


Tyr 
    


<210> 1832
<211> 51
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H3

<400> 1832
gcgaaggcat actgtagtaa taaggcctgc cacgggggct actttgacta c                51


<210> 1833
<211> 321
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region

<400> 1833
gaaacgacac tcacgcagtc tccagacacc ctgtccttgt ctccagggga aagggccacc       60

ctctcctgca gggccagtca gagtgttagg aactacttag cctggtaccg gcagaaacct      120

ggccaggctc ccaggctcct catctatgat gcatccaacc tggccactgg catcccagcc      180

aggttcagtg gcagcgggtc tgggacagac ttcactctca ccatcagcag cctagagcct      240

gaagattttg cagtttatta ctgtcaccag cgtagcgact ggccgctcac tttcggccct      300

gggaccaagg tggaaatcaa a                                                321


<210> 1834
<211> 107
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region

<400> 1834
Glu Thr Thr Leu Thr Gln Ser Pro Asp Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Arg Asn Tyr 
            20                  25                  30          


Leu Ala Trp Tyr Arg Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 
        35                  40                  45              


Tyr Asp Ala Ser Asn Leu Ala Thr Gly Ile Pro Ala Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Val Tyr Tyr Cys His Gln Arg Ser Asp Trp Pro Leu 
                85                  90                  95      


Thr Phe Gly Pro Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210> 1835
<211> 11
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region CDR L1

<400> 1835
Arg Ala Ser Gln Ser Val Arg Asn Tyr Leu Ala 
1               5                   10      


<210> 1836
<211> 33
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region CDR L1

<400> 1836
agggccagtc agagtgttag gaactactta gcc                                    33


<210> 1837
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region CDR L2

<400> 1837
Asp Ala Ser Asn Leu Ala Thr 
1               5           


<210> 1838
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region CDR L2

<400> 1838
gatgcatcca acctggccac t                                                 21


<210> 1839
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region CDR L3

<400> 1839
His Gln Arg Ser Asp Trp Pro Leu Thr 
1               5                   


<210> 1840
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region CDR L3

<400> 1840
caccagcgta gcgactggcc gctcact                                           27


<210> 1841
<211> 360
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region

<400> 1841
gaggtgcagc tggtggagtc ggggggaggc ttggtccagc ctggggggtc cctgagactc       60

tcctgtgcag cctctggatt cacctttagg agctattgga tgacctgggt ccgccaggct      120

ccagggaaag ggctggagtg ggtggccagc ataaacgatg aggggaatac taaatactat      180

gtggactctc tgaagggccg attcaccatc tccagagaca acgccaagaa ctcactttat      240

ctccaaatga acagcctgcg agccgaggac acggctgttt attactgtgc gagggagtcc      300

ggtctgcccc ggggtgcctt tcaaatctgg ggcccaggga caatggtcac cgtctcttca      360


<210> 1842
<211> 120
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region

<400> 1842
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Arg Ser Tyr 
            20                  25                  30          


Trp Met Thr Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Ser Ile Asn Asp Glu Gly Asn Thr Lys Tyr Tyr Val Asp Ser Leu 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Glu Ser Gly Leu Pro Arg Gly Ala Phe Gln Ile Trp Gly Pro 
            100                 105                 110         


Gly Thr Met Val Thr Val Ser Ser 
        115                 120 


<210> 1843
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H1

<400> 1843
Phe Thr Phe Arg Ser Tyr Trp Met Thr 
1               5                   


<210> 1844
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H1

<400> 1844
ttcaccttta ggagctattg gatgacc                                           27


<210> 1845
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H2

<400> 1845
Ser Ile Asn Asp Glu Gly Asn Thr Lys Tyr Tyr Val Asp Ser Leu Lys 
1               5                   10                  15      


Gly 
    


<210> 1846
<211> 51
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H2

<400> 1846
agcataaacg atgaggggaa tactaaatac tatgtggact ctctgaaggg c                51


<210> 1847
<211> 13
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H3

<400> 1847
Ala Arg Glu Ser Gly Leu Pro Arg Gly Ala Phe Gln Ile 
1               5                   10              


<210> 1848
<211> 39
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H3

<400> 1848
gcgagggagt ccggtctgcc ccggggtgcc tttcaaatc                              39


<210> 1849
<211> 318
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region

<400> 1849
gaaattgtat tgacacagtc tccagtcacc ctgtctttgt ctccagggga aagagccacc       60

ctctcatgca gggccagtca gagtgttggc accttcttag cctggtatca acacaaacct      120

ggccaggctc ccaggctcct catctatgat gcatccaaca gggcctctgc catcccagcc      180

aggttcagtg gcagtgggtc tgggacagac ttcactctca ccatcagcag cctggagcct      240

gaagattttg cagtttatta ctgtcagcat cgtagcgact ggtggacgtt cggccaaggg      300

accaaggtgg aaatcaaa                                                    318


<210> 1850
<211> 106
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region

<400> 1850
Glu Ile Val Leu Thr Gln Ser Pro Val Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Gly Thr Phe 
            20                  25                  30          


Leu Ala Trp Tyr Gln His Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 
        35                  40                  45              


Tyr Asp Ala Ser Asn Arg Ala Ser Ala Ile Pro Ala Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Val Tyr Tyr Cys Gln His Arg Ser Asp Trp Trp Thr 
                85                  90                  95      


Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105     


<210> 1851
<211> 11
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region CDR L1

<400> 1851
Arg Ala Ser Gln Ser Val Gly Thr Phe Leu Ala 
1               5                   10      


<210> 1852
<211> 33
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region CDR L1

<400> 1852
agggccagtc agagtgttgg caccttctta gcc                                    33


<210> 1853
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region CDR L2

<400> 1853
Asp Ala Ser Asn Arg Ala Ser 
1               5           


<210> 1854
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region CDR L2

<400> 1854
gatgcatcca acagggcctc t                                                 21


<210> 1855
<211> 8
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region CDR L3

<400> 1855
Gln His Arg Ser Asp Trp Trp Thr 
1               5               


<210> 1856
<211> 24
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region CDR L3

<400> 1856
cagcatcgta gcgactggtg gacg                                              24


<210> 1857
<211> 366
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region

<400> 1857
caggtgcagc tacagcagtg gggcgcagga ctgttgaagc cttcggagac cctgtccctc       60

acctgccaag tctatggtgt gtccttcagt gattactact ggaactggat ccgccagtcc      120

ccagggaagg gactggagtg gattggggac gtcaatcata ttggaaacac cgactacaac      180

ccgtccctca agagtcgagt ctccatatca gtagacacgt ccaagaacca gttctccctc      240

accctgcgct ctgtgaccgc cgcagacacg gctctatact actgtgcgag aggccgtaaa      300

ctttttgaag tgcctcccaa ggcccccgac tactggggcc agggaaccct ggtcaccgtc      360

tcctca                                                                 366


<210> 1858
<211> 122
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region

<400> 1858
Gln Val Gln Leu Gln Gln Trp Gly Ala Gly Leu Leu Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Gln Val Tyr Gly Val Ser Phe Ser Asp Tyr 
            20                  25                  30          


Tyr Trp Asn Trp Ile Arg Gln Ser Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Asp Val Asn His Ile Gly Asn Thr Asp Tyr Asn Pro Ser Leu Lys 
    50                  55                  60                  


Ser Arg Val Ser Ile Ser Val Asp Thr Ser Lys Asn Gln Phe Ser Leu 
65                  70                  75                  80  


Thr Leu Arg Ser Val Thr Ala Ala Asp Thr Ala Leu Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Gly Arg Lys Leu Phe Glu Val Pro Pro Lys Ala Pro Asp Tyr Trp 
            100                 105                 110         


Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120         


<210> 1859
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H1

<400> 1859
Val Ser Phe Ser Asp Tyr Tyr Trp Asn 
1               5                   


<210> 1860
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H1

<400> 1860
gtgtccttca gtgattacta ctggaac                                           27


<210> 1861
<211> 16
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H2

<400> 1861
Asp Val Asn His Ile Gly Asn Thr Asp Tyr Asn Pro Ser Leu Lys Ser 
1               5                   10                  15      


<210> 1862
<211> 48
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H2

<400> 1862
gacgtcaatc atattggaaa caccgactac aacccgtccc tcaagagt                    48


<210> 1863
<211> 16
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H3

<400> 1863
Ala Arg Gly Arg Lys Leu Phe Glu Val Pro Pro Lys Ala Pro Asp Tyr 
1               5                   10                  15      


<210> 1864
<211> 48
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H3

<400> 1864
gcgagaggcc gtaaactttt tgaagtgcct cccaaggccc ccgactac                    48


<210> 1865
<211> 324
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region

<400> 1865
gatattgtga tgacgcagtc tccaggcacc ctgtctttgt ctccagggga aagagccacc       60

ctctcctgca gggccagtca gagtgtgagc agcacctact tagcctggta ccagcagaag      120

cctggccagg ctcccaggct cctcatctat ggtgcgtcca tcagggccac tggcatccca      180

gacaggttca gtggcgttgg gtctgggaca gacttcactc tcaccatcag cagactggag      240

cctgaagatg ttgcagtgta ttactgtcag cagtatggga gctcacctca gacgttcggc      300

caagggacca aggtggaaat caaa                                             324


<210> 1866
<211> 108
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region

<400> 1866
Asp Ile Val Met Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Thr 
            20                  25                  30          


Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu 
        35                  40                  45              


Ile Tyr Gly Ala Ser Ile Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Val Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu 
65                  70                  75                  80  


Pro Glu Asp Val Ala Val Tyr Tyr Cys Gln Gln Tyr Gly Ser Ser Pro 
                85                  90                  95      


Gln Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105             


<210> 1867
<211> 12
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region CDR L1

<400> 1867
Arg Ala Ser Gln Ser Val Ser Ser Thr Tyr Leu Ala 
1               5                   10          


<210> 1868
<211> 36
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region CDR L1

<400> 1868
agggccagtc agagtgtgag cagcacctac ttagcc                                 36


<210> 1869
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region CDR L2

<400> 1869
Gly Ala Ser Ile Arg Ala Thr 
1               5           


<210> 1870
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region CDR L2

<400> 1870
ggtgcgtcca tcagggccac t                                                 21


<210> 1871
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region CDR L3

<400> 1871
Gln Gln Tyr Gly Ser Ser Pro Gln Thr 
1               5                   


<210> 1872
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region CDR L3

<400> 1872
cagcagtatg ggagctcacc tcagacg                                           27


<210> 1873
<211> 369
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region

<400> 1873
caggtgcagc tggtggagtc tgggggaggc ttgattcagc ctggggcgtc cctgagactc       60

tcctgtggag cctatggatt cagtttcagc agctctgcca tgagctgggt ccgccaggct      120

ccaggtaagg ggctggagtg ggtctcagct attagtgata atggtggtag cacatactac      180

gcagactccg tgcagggccg gttcaccatc tccagagaca attccaagaa cacgctgtat      240

ctgcaactga acaggctgag agccgaggac acggccatat attactgtgc gaaagcatat      300

tgtagtgata gctgccacgg gggctacttt gactactggg gccagggaac cctggtcacc      360

gtctcctca                                                              369


<210> 1874
<211> 123
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region

<400> 1874
Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Ile Gln Pro Gly Ala 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Gly Ala Tyr Gly Phe Ser Phe Ser Ser Ser 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ala Ile Ser Asp Asn Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Gln Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Leu Asn Arg Leu Arg Ala Glu Asp Thr Ala Ile Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Ala Tyr Cys Ser Asp Ser Cys His Gly Gly Tyr Phe Asp Tyr 
            100                 105                 110         


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120             


<210> 1875
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H1

<400> 1875
Phe Ser Phe Ser Ser Ser Ala Met Ser 
1               5                   


<210> 1876
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H1

<400> 1876
ttcagtttca gcagctctgc catgagc                                           27


<210> 1877
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H2

<400> 1877
Ala Ile Ser Asp Asn Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val Gln 
1               5                   10                  15      


Gly 
    


<210> 1878
<211> 51
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H2

<400> 1878
gctattagtg ataatggtgg tagcacatac tacgcagact ccgtgcaggg c                51


<210> 1879
<211> 16
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H3

<400> 1879
Ala Lys Ala Tyr Cys Ser Asp Ser Cys His Gly Gly Tyr Phe Asp Tyr 
1               5                   10                  15      


<210> 1880
<211> 48
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H3

<400> 1880
gcgaaagcat attgtagtga tagctgccac gggggctact ttgactac                    48


<210> 1881
<211> 321
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region

<400> 1881
gaaattgtgt tgacgcagtc tccagccacc ctgtctttgt ctccagggga tagagccacc       60

ctctcctgca gggccagtca gagtgttagc agctccttcg cctggtacca acagaaacct      120

ggccaggctc ccaggctcct catctatgct gtatccaaca gggccactgg catcccagcc      180

aggttcagtg gcagtgggtc tgggacagac ttcactctca ccatcagcac cctagagcct      240

gaagactttg cagtttatta ctgtcagcag cgtagcacct ggccgctcac tttcggccct      300

gggaccaagg tggagatcaa a                                                321


<210> 1882
<211> 107
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region

<400> 1882
Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Asp Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Ser 
            20                  25                  30          


Phe Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 
        35                  40                  45              


Tyr Ala Val Ser Asn Arg Ala Thr Gly Ile Pro Ala Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Thr Leu Glu Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Arg Ser Thr Trp Pro Leu 
                85                  90                  95      


Thr Phe Gly Pro Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210> 1883
<211> 11
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region CDR L1

<400> 1883
Arg Ala Ser Gln Ser Val Ser Ser Ser Phe Ala 
1               5                   10      


<210> 1884
<211> 33
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region CDR L1

<400> 1884
agggccagtc agagtgttag cagctccttc gcc                                    33


<210> 1885
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region CDR L2

<400> 1885
Ala Val Ser Asn Arg Ala Thr 
1               5           


<210> 1886
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region CDR L2

<400> 1886
gctgtatcca acagggccac t                                                 21


<210> 1887
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region CDR L3

<400> 1887
Gln Gln Arg Ser Thr Trp Pro Leu Thr 
1               5                   


<210> 1888
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region CDR L3

<400> 1888
cagcagcgta gcacctggcc gctcact                                           27


<210> 1889
<211> 384
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region

<400> 1889
gaggtgcagc tgttggagtc ggggggaggc ttggtgaagc ctggggggtc cctaagactc       60

tcatgtgcag cctctggatt cattttcact aacgcctgga tgagctgggt ccgccaggct      120

ccagggaagg ggctggagtg ggttggccgt attaaaagga aaactgaaac tgggacaaca      180

gactacgctc cacccgtgaa aggcagattc accatctcaa gagatgattc aagaagcacg      240

ctgtatctgc aaatgaacag cctgaaaacc gaggacacag ccgtgtatta ctgtacgaca      300

ggcccaccct atcagtacta tgacagtact ggttattcgg tcgttgacta ctggggccag      360

ggaaccctgg tcaccgtctc ctca                                             384


<210> 1890
<211> 128
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region

<400> 1890
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ile Phe Thr Asn Ala 
            20                  25                  30          


Trp Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Gly Arg Ile Lys Arg Lys Thr Glu Thr Gly Thr Thr Asp Tyr Ala Pro 
    50                  55                  60                  


Pro Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Arg Ser Thr 
65                  70                  75                  80  


Leu Tyr Leu Gln Met Asn Ser Leu Lys Thr Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Thr Thr Gly Pro Pro Tyr Gln Tyr Tyr Asp Ser Thr Gly Tyr 
            100                 105                 110         


Ser Val Val Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125             


<210> 1891
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H1

<400> 1891
Phe Ile Phe Thr Asn Ala Trp Met Ser 
1               5                   


<210> 1892
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H1

<400> 1892
ttcattttca ctaacgcctg gatgagc                                           27


<210> 1893
<211> 19
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H2

<400> 1893
Arg Ile Lys Arg Lys Thr Glu Thr Gly Thr Thr Asp Tyr Ala Pro Pro 
1               5                   10                  15      


Val Lys Gly 
            


<210> 1894
<211> 57
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H2

<400> 1894
cgtattaaaa ggaaaactga aactgggaca acagactacg ctccacccgt gaaaggc          57


<210> 1895
<211> 19
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H3

<400> 1895
Thr Thr Gly Pro Pro Tyr Gln Tyr Tyr Asp Ser Thr Gly Tyr Ser Val 
1               5                   10                  15      


Val Asp Tyr 
            


<210> 1896
<211> 57
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H3

<400> 1896
acgacaggcc caccctatca gtactatgac agtactggtt attcggtcgt tgactac          57


<210> 1897
<211> 342
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region

<400> 1897
tcctatgagc tgactcagcc accctcagcg tccgggaccc ccgggcagag ggtcaccatc       60

tcttgttctg gaagcagctc caacatcgga agtaacatcg gaattaatta tgtatactgg      120

taccagcagc tcccaggaac ggcccccaaa ctcctcatct acagtactaa tcagcggccc      180

tcaggggtcc ctgaccgatt ctctggctcc cagtctggca cctcagcctc cctggccatc      240

agtgggctcc ggtccgagga tgaggctgat tattactgtg cagcatggga tgacagcctg      300

agtggtccgg tgttcggcgg agggaccaag ctcaccgtcc ta                         342


<210> 1898
<211> 114
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region

<400> 1898
Ser Tyr Glu Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln 
1               5                   10                  15      


Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn 
            20                  25                  30          


Ile Gly Ile Asn Tyr Val Tyr Trp Tyr Gln Gln Leu Pro Gly Thr Ala 
        35                  40                  45              


Pro Lys Leu Leu Ile Tyr Ser Thr Asn Gln Arg Pro Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gln Ser Gly Thr Ser Ala Ser Leu Ala Ile 
65                  70                  75                  80  


Ser Gly Leu Arg Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp 
                85                  90                  95      


Asp Asp Ser Leu Ser Gly Pro Val Phe Gly Gly Gly Thr Lys Leu Thr 
            100                 105                 110         


Val Leu 
        


<210> 1899
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region CDR L1

<400> 1899
Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn Ile Gly Ile Asn Tyr Val 
1               5                   10                  15      


Tyr 
    


<210> 1900
<211> 51
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region CDR L1

<400> 1900
tctggaagca gctccaacat cggaagtaac atcggaatta attatgtata c                51


<210> 1901
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region CDR L2

<400> 1901
Ser Thr Asn Gln Arg Pro Ser 
1               5           


<210> 1902
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region CDR L2

<400> 1902
agtactaatc agcggccctc a                                                 21


<210> 1903
<211> 11
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region CDR L3

<400> 1903
Ala Ala Trp Asp Asp Ser Leu Ser Gly Pro Val 
1               5                   10      


<210> 1904
<211> 33
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region CDR L3

<400> 1904
gcagcatggg atgacagcct gagtggtccg gtg                                    33


<210> 1905
<211> 360
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region

<400> 1905
caggtgcagc tggtgcagtc tggaccagag ttgaaaaagc ccggggagtc tctgaagatc       60

tcctgtaagg cttctggata cagctttacc tccttctgga tcgcttgggt gcgccagatg      120

cccgggaaag gcctggagtt tctggggatc atctatcctg gtgacgctga caccagatac      180

agtccgtcct tccaaggcca agtcaccatc tcagccgaca agtccatcaa caccgcctac      240

ctgcagtgga acaacctgaa ggcctcggac accgccatgt attactgtgc gagacagact      300

acgatgaccc ccgatgcttt tgatctctgg ggccaaggga ccacggtcac cgtctcctca      360


<210> 1906
<211> 120
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region

<400> 1906
Gln Val Gln Leu Val Gln Ser Gly Pro Glu Leu Lys Lys Pro Gly Glu 
1               5                   10                  15      


Ser Leu Lys Ile Ser Cys Lys Ala Ser Gly Tyr Ser Phe Thr Ser Phe 
            20                  25                  30          


Trp Ile Ala Trp Val Arg Gln Met Pro Gly Lys Gly Leu Glu Phe Leu 
        35                  40                  45              


Gly Ile Ile Tyr Pro Gly Asp Ala Asp Thr Arg Tyr Ser Pro Ser Phe 
    50                  55                  60                  


Gln Gly Gln Val Thr Ile Ser Ala Asp Lys Ser Ile Asn Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Trp Asn Asn Leu Lys Ala Ser Asp Thr Ala Met Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gln Thr Thr Met Thr Pro Asp Ala Phe Asp Leu Trp Gly Gln 
            100                 105                 110         


Gly Thr Thr Val Thr Val Ser Ser 
        115                 120 


<210> 1907
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H1

<400> 1907
Tyr Ser Phe Thr Ser Phe Trp Ile Ala 
1               5                   


<210> 1908
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H1

<400> 1908
tacagcttta cctccttctg gatcgct                                           27


<210> 1909
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H2

<400> 1909
Ile Ile Tyr Pro Gly Asp Ala Asp Thr Arg Tyr Ser Pro Ser Phe Gln 
1               5                   10                  15      


Gly 
    


<210> 1910
<211> 51
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H2

<400> 1910
atcatctatc ctggtgacgc tgacaccaga tacagtccgt ccttccaagg c                51


<210> 1911
<211> 13
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H3

<400> 1911
Ala Arg Gln Thr Thr Met Thr Pro Asp Ala Phe Asp Leu 
1               5                   10              


<210> 1912
<211> 39
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H3

<400> 1912
gcgagacaga ctacgatgac ccccgatgct tttgatctc                              39


<210> 1913
<211> 324
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region

<400> 1913
gaaattgtgt tgacacagtc tccagccacc ctgtctttgt ctccagggga aagagccact       60

atctcctgca gggccagtca gagtgttagc agctacttag cctggtacca acagaaacct      120

ggccaggctc ccaggctcct catctatgaa gcatccgaca gggccactgg caccccagcc      180

aggttcagtg gcagtgggtc tgggacagac ttcactctca ccatcagcag cctagagcct      240

gaggattttg cagtttatta ctgtcagcag cgtagtaact ggggggtagg aacgttcggc      300

caagggacca aggtggaaat caaa                                             324


<210> 1914
<211> 108
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region

<400> 1914
Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Ile Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Tyr 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 
        35                  40                  45              


Tyr Glu Ala Ser Asp Arg Ala Thr Gly Thr Pro Ala Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Arg Ser Asn Trp Gly Val 
                85                  90                  95      


Gly Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105             


<210> 1915
<211> 11
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region CDR L1

<400> 1915
Arg Ala Ser Gln Ser Val Ser Ser Tyr Leu Ala 
1               5                   10      


<210> 1916
<211> 33
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region CDR L1

<400> 1916
agggccagtc agagtgttag cagctactta gcc                                    33


<210> 1917
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region CDR L2

<400> 1917
Glu Ala Ser Asp Arg Ala Thr 
1               5           


<210> 1918
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region CDR L2

<400> 1918
gaagcatccg acagggccac t                                                 21


<210> 1919
<211> 10
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region CDR L3

<400> 1919
Gln Gln Arg Ser Asn Trp Gly Val Gly Thr 
1               5                   10  


<210> 1920
<211> 30
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region CDR L3

<400> 1920
cagcagcgta gtaactgggg ggtaggaacg                                        30


<210> 1921
<211> 387
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region

<400> 1921
caggtgcagc tggtgcagtc tggggctgag gtgaagaagc ctgggtcctc ggtgagggtc       60

acctgcaagg cttctggagg caccgtcagc gactatgcaa tcacctgggt ccgacaggcg      120

cctggacaag ggcttgagtg gatgggaggg ttcatcccta tgtttggtgt cgcaaaggac      180

gcagagaagt tccagggcag agtcacgctg actggggaca aatccacgaa cgcagtttac      240

atggagctga gcagcctgac atctgaagac acggccgtct attactgtgc gagatcgaag      300

agactaccag ctggtttatc tacgtctgac tactactact actatttgga cgtctggggc      360

aaagggacca cggtcaccgt ctcctca                                          387


<210> 1922
<211> 129
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region

<400> 1922
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Arg Val Thr Cys Lys Ala Ser Gly Gly Thr Val Ser Asp Tyr 
            20                  25                  30          


Ala Ile Thr Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Gly Phe Ile Pro Met Phe Gly Val Ala Lys Asp Ala Glu Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Leu Thr Gly Asp Lys Ser Thr Asn Ala Val Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Thr Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ser Lys Arg Leu Pro Ala Gly Leu Ser Thr Ser Asp Tyr Tyr 
            100                 105                 110         


Tyr Tyr Tyr Leu Asp Val Trp Gly Lys Gly Thr Thr Val Thr Val Ser 
        115                 120                 125             


Ser 
    


<210> 1923
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H1

<400> 1923
Gly Thr Val Ser Asp Tyr Ala Ile Thr 
1               5                   


<210> 1924
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H1

<400> 1924
ggcaccgtca gcgactatgc aatcacc                                           27


<210> 1925
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H2

<400> 1925
Gly Phe Ile Pro Met Phe Gly Val Ala Lys Asp Ala Glu Lys Phe Gln 
1               5                   10                  15      


Gly 
    


<210> 1926
<211> 51
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H2

<400> 1926
gggttcatcc ctatgtttgg tgtcgcaaag gacgcagaga agttccaggg c                51


<210> 1927
<211> 22
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H3

<400> 1927
Ala Arg Ser Lys Arg Leu Pro Ala Gly Leu Ser Thr Ser Asp Tyr Tyr 
1               5                   10                  15      


Tyr Tyr Tyr Leu Asp Val 
            20          


<210> 1928
<211> 66
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H3

<400> 1928
gcgagatcga agagactacc agctggttta tctacgtctg actactacta ctactatttg       60

gacgtc                                                                  66


<210> 1929
<211> 324
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region

<400> 1929
gaaattgtat tgacacagtc tccaggcacc ctgtctttgt ctccagggga aggagccacc       60

ctctcctgta cggccagtca gaatgttttc cgcacccacg tagcctggta ccagcagact      120

cctggccagg ctcccaggct cctcatctat ggtgggtcca ccagggccac tggcatccca      180

gacaggttca gtggcagcgg gtctgggaca gacttcactc tcatcatcag cagactggaa      240

cctgaagatt ttgcagtcta ttactgtcat cactttggta ccacaccgtg gacgttcggc      300

caagggacca aggtggagat caaa                                             324


<210> 1930
<211> 108
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region

<400> 1930
Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Gly Ala Thr Leu Ser Cys Thr Ala Ser Gln Asn Val Phe Arg Thr 
            20                  25                  30          


His Val Ala Trp Tyr Gln Gln Thr Pro Gly Gln Ala Pro Arg Leu Leu 
        35                  40                  45              


Ile Tyr Gly Gly Ser Thr Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Ile Ile Ser Arg Leu Glu 
65                  70                  75                  80  


Pro Glu Asp Phe Ala Val Tyr Tyr Cys His His Phe Gly Thr Thr Pro 
                85                  90                  95      


Trp Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105             


<210> 1931
<211> 12
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region CDR L1

<400> 1931
Thr Ala Ser Gln Asn Val Phe Arg Thr His Val Ala 
1               5                   10          


<210> 1932
<211> 36
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region CDR L1

<400> 1932
acggccagtc agaatgtttt ccgcacccac gtagcc                                 36


<210> 1933
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region CDR L2

<400> 1933
Gly Gly Ser Thr Arg Ala Thr 
1               5           


<210> 1934
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region CDR L2

<400> 1934
ggtgggtcca ccagggccac t                                                 21


<210> 1935
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region CDR L3

<400> 1935
His His Phe Gly Thr Thr Pro Trp Thr 
1               5                   


<210> 1936
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region CDR L3

<400> 1936
catcactttg gtaccacacc gtggacg                                           27


<210> 1937
<211> 369
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region

<400> 1937
gaggtgcagc tggtggagtc tgggcctgag gtgaaggggc ctgggtcctc ggtgaaagtc       60

tcatgcgagg cttctgcagc caccttcagc aactacgcta tcagctgggt ccgacaggcc      120

cctggacaag ggcttgagtg gatgggaggg ttcgtcccta tgttagggac aaggaactac      180

gcacagaagt tcaagggcag agtcactctg accgcggacg tatccacaca tacattgtac      240

ttggagattg gtagtctgag atttgaggac acggccgtgt attactgtgc gacagtggcc      300

ggtctgggaa ccagctatgg tcgatacctt gagtcttggg gccagggaac cctggtcacc      360

gtctcctca                                                              369


<210> 1938
<211> 123
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region

<400> 1938
Glu Val Gln Leu Val Glu Ser Gly Pro Glu Val Lys Gly Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Glu Ala Ser Ala Ala Thr Phe Ser Asn Tyr 
            20                  25                  30          


Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Gly Phe Val Pro Met Leu Gly Thr Arg Asn Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Lys Gly Arg Val Thr Leu Thr Ala Asp Val Ser Thr His Thr Leu Tyr 
65                  70                  75                  80  


Leu Glu Ile Gly Ser Leu Arg Phe Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Thr Val Ala Gly Leu Gly Thr Ser Tyr Gly Arg Tyr Leu Glu Ser 
            100                 105                 110         


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120             


<210> 1939
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H1

<400> 1939
Ala Thr Phe Ser Asn Tyr Ala Ile Ser 
1               5                   


<210> 1940
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H1

<400> 1940
gccaccttca gcaactacgc tatcagc                                           27


<210> 1941
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H2

<400> 1941
Gly Phe Val Pro Met Leu Gly Thr Arg Asn Tyr Ala Gln Lys Phe Lys 
1               5                   10                  15      


Gly 
    


<210> 1942
<211> 51
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H2

<400> 1942
gggttcgtcc ctatgttagg gacaaggaac tacgcacaga agttcaaggg c                51


<210> 1943
<211> 16
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H3

<400> 1943
Ala Thr Val Ala Gly Leu Gly Thr Ser Tyr Gly Arg Tyr Leu Glu Ser 
1               5                   10                  15      


<210> 1944
<211> 48
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H3

<400> 1944
gcgacagtgg ccggtctggg aaccagctat ggtcgatacc ttgagtct                    48


<210> 1945
<211> 321
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region

<400> 1945
gacatccgga tgacccagtc tccatcttct gtgtctgcgt ctcttggaga cagagtcacc       60

atcacttgtc gggcgagtca ggatattagc accgcgttag cctggtatca gcagatacca      120

gggaaggccc ctaaactcct gatctatgaa gcatccagtt tgcaaagtgg ggtcccatcc      180

aggttcaggg gcagtggatc tgagacagac ttcgctctca ctatcagcag cctgcagcct      240

gaagattttg caacttacta ttgtcaacag gcaaagagtt tcccgtacac ttttggccag      300

gggaccaagg tggagatcaa a                                                321


<210> 1946
<211> 107
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region

<400> 1946
Asp Ile Arg Met Thr Gln Ser Pro Ser Ser Val Ser Ala Ser Leu Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Ile Ser Thr Ala 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Ile Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Glu Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Arg Gly 
    50                  55                  60                  


Ser Gly Ser Glu Thr Asp Phe Ala Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ala Lys Ser Phe Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210> 1947
<211> 11
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region CDR L1

<400> 1947
Arg Ala Ser Gln Asp Ile Ser Thr Ala Leu Ala 
1               5                   10      


<210> 1948
<211> 33
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region CDR L1

<400> 1948
cgggcgagtc aggatattag caccgcgtta gcc                                    33


<210> 1949
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region CDR L2

<400> 1949
Glu Ala Ser Ser Leu Gln Ser 
1               5           


<210> 1950
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region CDR L2

<400> 1950
gaagcatcca gtttgcaaag t                                                 21


<210> 1951
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region CDR L3

<400> 1951
Gln Gln Ala Lys Ser Phe Pro Tyr Thr 
1               5                   


<210> 1952
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region CDR L3

<400> 1952
caacaggcaa agagtttccc gtacact                                           27


<210> 1953
<211> 375
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region

<400> 1953
caggtccagc tggtgcagtc tgggggaggc ttggcgcagc ctggagggtc cctgagactc       60

tcctgtgcag cctccggatt catcttcagt gtttatgaaa tggactgggt ccgccaggct      120

ccagggaagg ggctggagtg gctttcatac attgatatta ctggtaatag tgtaacctat      180

gcagactctg tgaggggccg gttcaccatc tccagagaca acgccaggaa ctcactctac      240

ctgcaaatgg acagcctgag agtcgaggac acggctgtat attattgtgt tagagatagt      300

cgcggcccta caacgcagtg gctcacggga tactttgact tctggggcca ggggaccacg      360

gtcaccgtct cctca                                                       375


<210> 1954
<211> 125
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region

<400> 1954
Gln Val Gln Leu Val Gln Ser Gly Gly Gly Leu Ala Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ile Phe Ser Val Tyr 
            20                  25                  30          


Glu Met Asp Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Leu 
        35                  40                  45              


Ser Tyr Ile Asp Ile Thr Gly Asn Ser Val Thr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Arg Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Arg Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asp Ser Leu Arg Val Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Val Arg Asp Ser Arg Gly Pro Thr Thr Gln Trp Leu Thr Gly Tyr Phe 
            100                 105                 110         


Asp Phe Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120                 125 


<210> 1955
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H1

<400> 1955
Phe Ile Phe Ser Val Tyr Glu Met Asp 
1               5                   


<210> 1956
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H1

<400> 1956
ttcatcttca gtgtttatga aatggac                                           27


<210> 1957
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H2

<400> 1957
Tyr Ile Asp Ile Thr Gly Asn Ser Val Thr Tyr Ala Asp Ser Val Arg 
1               5                   10                  15      


Gly 
    


<210> 1958
<211> 51
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H2

<400> 1958
tacattgata ttactggtaa tagtgtaacc tatgcagact ctgtgagggg c                51


<210> 1959
<211> 18
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H3

<400> 1959
Val Arg Asp Ser Arg Gly Pro Thr Thr Gln Trp Leu Thr Gly Tyr Phe 
1               5                   10                  15      


Asp Phe 
        


<210> 1960
<211> 54
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      heavy chain variable region CDR H3

<400> 1960
gttagagata gtcgcggccc tacaacgcag tggctcacgg gatactttga cttc             54


<210> 1961
<211> 324
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region

<400> 1961
gacatccgga tgacccagtc tccagccacc ctgtctttgt ctccagggga aagagccacc       60

ctctcctgca gggccagtca gagtgttagc aactacttag cctggtacca acagaaacct      120

ggccaggctc ccaggctcct catctatgat gtatccaata gggccactgg catcccagcc      180

aggttcagtg gcagtgggtc cgggacagac ttcactctca ccatcagcag cctggagcct      240

gaagattttg cagtttatta ctgtcagcag cgtcgcaact ggcctccgct cactttcggc      300

ggagggacca aggtggaggt caaa                                             324


<210> 1962
<211> 108
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region

<400> 1962
Asp Ile Arg Met Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Asn Tyr 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 
        35                  40                  45              


Tyr Asp Val Ser Asn Arg Ala Thr Gly Ile Pro Ala Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Arg Arg Asn Trp Pro Pro 
                85                  90                  95      


Leu Thr Phe Gly Gly Gly Thr Lys Val Glu Val Lys 
            100                 105             


<210> 1963
<211> 11
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region CDR L1

<400> 1963
Arg Ala Ser Gln Ser Val Ser Asn Tyr Leu Ala 
1               5                   10      


<210> 1964
<211> 33
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region CDR L1

<400> 1964
agggccagtc agagtgttag caactactta gcc                                    33


<210> 1965
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region CDR L2

<400> 1965
Asp Val Ser Asn Arg Ala Thr 
1               5           


<210> 1966
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region CDR L2

<400> 1966
gatgtatcca atagggccac t                                                 21


<210> 1967
<211> 10
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region CDR L3

<400> 1967
Gln Gln Arg Arg Asn Trp Pro Pro Leu Thr 
1               5                   10  


<210> 1968
<211> 30
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      light chain variable region CDR L3

<400> 1968
cagcagcgtc gcaactggcc tccgctcact                                        30



