                         SEQUENCE LISTING

<110>  California Institute for Biomedical Research
       Young, Travis S.
       Presta, Leonard
       Rodgers, David
       Hampton, Eric
       Wright, Timothy
       Schultz, Peter G.
       Laborda, Eduardo
       Hampton, Eric
       Khialeeva, Elvira
       Viaud, Sophie
 
<120>  CHIMERIC ANTIGEN  RECEPTOR EFFECTOR CELL SWITCHES WITH HUMANIZED 
       TARGETING MOIETIES AND/OR OPTIMIZED CHIMERIC ANTIGEN RECEPTOR 
       INTERACTING DOMAINS AND USES THEREOF

<130>  CIBR-011/01WO  323414-2049

<150>  US 62/410,315
<151>  2016-10-19

<160>  423   

<170>  PatentIn version 3.5

<210>  1
<211>  97
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized heavy chain sequence

<400>  1

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Gly Ser Ile Ser Ser Tyr 
            20                  25                  30          


Tyr Trp Ser Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Tyr Ile Tyr Tyr Ser Gly Ser Thr Asn Tyr Asn Pro Ser Leu Lys 
    50                  55                  60                  


Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe Ser Leu 
65                  70                  75                  80  


Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg 
    


<210>  2
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized heavy chain sequence

<400>  2

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Val Ser Leu Pro Asp Tyr 
            20                  25                  30          


Gly Val Ser Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Val Ile Trp Gly Ser Glu Thr Thr Tyr Tyr Asn Pro Ser Leu Lys 
    50                  55                  60                  


Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe Ser Leu 
65                  70                  75                  80  


Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg His Tyr Tyr Tyr Gly Gly Ser Tyr Ala Met Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser 
        115                 120 


<210>  3
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized heavy chain sequence

<400>  3

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Val Thr Cys Thr Val Ser Gly Val Ser Leu Pro Asp Tyr 
            20                  25                  30          


Gly Val Ser Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Leu 
        35                  40                  45              


Gly Val Ile Trp Gly Ser Glu Thr Thr Tyr Tyr Asn Pro Ser Leu Lys 
    50                  55                  60                  


Ser Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Val Ser Leu 
65                  70                  75                  80  


Lys Met Ser Ser Leu Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg His Tyr Tyr Tyr Gly Gly Ser Tyr Ala Met Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser 
        115                 120 


<210>  4
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized heavy chain sequence

<400>  4

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Val Thr Cys Thr Val Ser Gly Val Ser Leu Pro Asp Tyr 
            20                  25                  30          


Gly Val Ser Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Leu 
        35                  40                  45              


Gly Val Ile Trp Gly Ser Glu Thr Thr Tyr Tyr Asn Pro Ser Leu Lys 
    50                  55                  60                  


Ser Arg Leu Thr Ile Ser Lys Asp Asn Ser Lys Asn Gln Val Ser Leu 
65                  70                  75                  80  


Lys Met Ser Ser Leu Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg His Tyr Tyr Tyr Gly Gly Ser Tyr Ala Met Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser 
        115                 120 


<210>  5
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized heavy chain sequence

<400>  5

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Val Thr Cys Thr Val Ser Gly Val Ser Leu Pro Asp Tyr 
            20                  25                  30          


Gly Val Ser Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Leu 
        35                  40                  45              


Gly Val Ile Trp Gly Ser Glu Thr Thr Tyr Tyr Asn Pro Ser Leu Lys 
    50                  55                  60                  


Ser Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Val Ser Leu 
65                  70                  75                  80  


Lys Met Ser Ser Leu Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Lys His Tyr Tyr Tyr Gly Gly Ser Tyr Ala Met Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser 
        115                 120 


<210>  6
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized heavy chain sequence

<400>  6

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Val Thr Cys Thr Val Ser Gly Val Ser Leu Pro Asp Tyr 
            20                  25                  30          


Gly Val Ser Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Leu 
        35                  40                  45              


Gly Val Ile Trp Gly Ser Glu Thr Thr Tyr Tyr Asn Pro Ser Leu Lys 
    50                  55                  60                  


Ser Arg Leu Thr Ile Ser Lys Asp Asn Ser Lys Asn Gln Val Ser Leu 
65                  70                  75                  80  


Lys Met Ser Ser Leu Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Lys His Tyr Tyr Tyr Gly Gly Ser Tyr Ala Met Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser 
        115                 120 


<210>  7
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized heavy chain sequence

<400>  7

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Val Thr Cys Thr Val Ser Gly Val Ser Leu Pro Asp Tyr 
            20                  25                  30          


Gly Val Ser Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Leu 
        35                  40                  45              


Gly Val Ile Trp Gly Ser Glu Thr Thr Tyr Tyr Asn Ser Ala Leu Lys 
    50                  55                  60                  


Ser Arg Leu Thr Ile Ser Lys Asp Asn Ser Lys Asn Gln Val Ser Leu 
65                  70                  75                  80  


Lys Met Ser Ser Leu Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Lys His Tyr Tyr Tyr Gly Gly Ser Tyr Ala Met Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser 
        115                 120 


<210>  8
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized heavy chain sequence

<400>  8

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Val Thr Cys Thr Val Ser Gly Val Ser Leu Pro Asp Tyr 
            20                  25                  30          


Gly Val Ser Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Leu 
        35                  40                  45              


Gly Val Ile Trp Gly Ser Glu Thr Thr Tyr Tyr Asn Ser Ser Leu Lys 
    50                  55                  60                  


Ser Arg Leu Thr Ile Ser Lys Asp Asn Ser Lys Asn Gln Val Ser Leu 
65                  70                  75                  80  


Lys Met Ser Ser Leu Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Lys His Tyr Tyr Tyr Gly Gly Ser Tyr Ala Met Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser 
        115                 120 


<210>  9
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized heavy chain sequence

<400>  9

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Val Ser Leu Pro Asp Tyr 
            20                  25                  30          


Gly Val Ser Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Val Ile Trp Gly Ser Glu Thr Thr Tyr Tyr Asn Pro Ser Leu Lys 
    50                  55                  60                  


Ser Arg Val Thr Ile Ser Lys Asp Asn Ser Lys Asn Gln Phe Ser Leu 
65                  70                  75                  80  


Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Lys His Tyr Tyr Tyr Gly Gly Ser Tyr Ala Met Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser 
        115                 120 


<210>  10
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized heavy chain sequence

<400>  10

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Val Ser Leu Pro Asp Tyr 
            20                  25                  30          


Gly Val Ser Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Val Ile Trp Gly Ser Glu Thr Thr Tyr Tyr Asn Ser Ala Leu Lys 
    50                  55                  60                  


Ser Arg Val Thr Ile Ser Lys Asp Asn Ser Lys Asn Gln Phe Ser Leu 
65                  70                  75                  80  


Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Lys His Tyr Tyr Tyr Gly Gly Ser Tyr Ala Met Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser 
        115                 120 


<210>  11
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized heavy chain sequence

<400>  11

Glu Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Val Ser Leu Pro Asp Tyr 
            20                  25                  30          


Gly Val Ser Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Leu 
        35                  40                  45              


Gly Val Ile Trp Gly Ser Glu Thr Thr Tyr Tyr Asn Ser Ala Leu Lys 
    50                  55                  60                  


Ser Arg Leu Thr Ile Ser Lys Asp Asn Ser Lys Asn Gln Val Ser Leu 
65                  70                  75                  80  


Lys Met Ser Ser Leu Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Lys His Tyr Tyr Tyr Gly Gly Ser Tyr Ala Met Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser 
        115                 120 


<210>  12
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized heavy chain sequence

<400>  12

Glu Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Val Thr Cys Thr Val Ser Gly Val Ser Leu Pro Asp Tyr 
            20                  25                  30          


Gly Val Ser Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Leu 
        35                  40                  45              


Gly Val Ile Trp Gly Ser Glu Thr Thr Tyr Tyr Asn Pro Ser Leu Lys 
    50                  55                  60                  


Ser Arg Leu Thr Ile Ser Lys Asp Asn Ser Lys Asn Gln Val Ser Leu 
65                  70                  75                  80  


Lys Met Ser Ser Leu Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Lys His Tyr Tyr Tyr Gly Gly Ser Tyr Ala Met Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser 
        115                 120 


<210>  13
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized heavy chain sequence

<400>  13

Glu Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Val Thr Cys Thr Val Ser Gly Val Ser Leu Pro Asp Tyr 
            20                  25                  30          


Gly Val Ser Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Leu 
        35                  40                  45              


Gly Val Ile Trp Gly Ser Glu Thr Thr Tyr Tyr Asn Ser Ala Leu Lys 
    50                  55                  60                  


Ser Arg Leu Thr Ile Ser Lys Asp Asn Ser Lys Asn Gln Val Ser Leu 
65                  70                  75                  80  


Lys Met Ser Ser Leu Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Lys His Tyr Tyr Tyr Gly Gly Ser Tyr Ala Met Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser 
        115                 120 


<210>  14
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized heavy chain sequence

<400>  14

Glu Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Val Ser Leu Pro Asp Tyr 
            20                  25                  30          


Gly Val Ser Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Leu 
        35                  40                  45              


Gly Val Ile Trp Gly Ser Glu Thr Thr Tyr Tyr Asn Pro Ser Leu Lys 
    50                  55                  60                  


Ser Arg Leu Thr Ile Ser Lys Asp Asn Ser Lys Asn Gln Val Ser Leu 
65                  70                  75                  80  


Lys Met Ser Ser Leu Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Lys His Tyr Tyr Tyr Gly Gly Ser Tyr Ala Met Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser 
        115                 120 


<210>  15
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized heavy chain sequence

<400>  15

Glu Val Lys Leu Gln Glu Ser Gly Pro Gly Leu Val Ala Pro Ser Gln 
1               5                   10                  15      


Ser Leu Ser Val Thr Cys Thr Val Ser Gly Val Ser Leu Pro Asp Tyr 
            20                  25                  30          


Gly Val Ser Trp Ile Arg Gln Pro Pro Arg Lys Gly Leu Glu Trp Leu 
        35                  40                  45              


Gly Val Ile Trp Gly Ser Glu Thr Thr Tyr Tyr Asn Ser Ala Leu Lys 
    50                  55                  60                  


Ser Arg Leu Thr Ile Ile Lys Asp Asn Ser Lys Ser Gln Val Phe Leu 
65                  70                  75                  80  


Lys Met Asn Ser Leu Gln Thr Asp Asp Thr Ala Ile Tyr Tyr Cys Ala 
                85                  90                  95      


Lys His Tyr Tyr Tyr Gly Gly Ser Tyr Ala Met Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Ser Val Thr Val Ser Ser 
        115                 120 


<210>  16
<211>  96
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized light chain sequence

<400>  16

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Tyr Ser Thr Pro Pro 
                85                  90                  95      


<210>  17
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized light chain sequence

<400>  17

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Ile Ser Lys Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr His Thr Ser Arg Leu His Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Gly Asn Thr Leu Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  18
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized light chain sequence

<400>  18

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Ile Ser Lys Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr His Thr Ser Arg Leu His Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Tyr Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Gly Ala Thr Leu Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  19
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized light chain sequence

<400>  19

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Ile Ser Lys Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Val Lys Leu Leu Ile 
        35                  40                  45              


Tyr His Thr Ser Arg Leu His Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Tyr Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Gly Ala Thr Leu Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  20
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized light chain sequence

<400>  20

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Ile Ser Lys Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Val Lys Leu Leu Ile 
        35                  40                  45              


Tyr His Thr Ser Arg Leu His Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Tyr Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Phe Cys Gln Gln Gly Ala Thr Leu Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  21
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized light chain sequence

<400>  21

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Ile Ser Lys Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr His Thr Ser Arg Leu His Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Tyr Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Phe Cys Gln Gln Gly Ala Thr Leu Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  22
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized light chain sequence

<400>  22

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Ile Ser Lys Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Leu Lys Leu Leu Ile 
        35                  40                  45              


Tyr His Thr Ser Arg Leu His Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Tyr Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Phe Cys Gln Gln Gly Ala Thr Leu Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  23
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized light chain sequence

<400>  23

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Ile Ser Lys Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Val Lys Leu Leu Ile 
        35                  40                  45              


Tyr His Thr Ser Arg Leu His Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Tyr Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Phe Cys Gln Gln Gly Asn Thr Leu Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  24
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized light chain sequence

<400>  24

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Ile Ser Lys Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Ile Lys Leu Leu Ile 
        35                  40                  45              


Tyr His Thr Ser Arg Leu His Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Tyr Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Phe Cys Gln Gln Gly Ala Thr Leu Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  25
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized light chain sequence

<400>  25

Asp Ile Gln Met Thr Gln Thr Thr Ser Ser Leu Ser Ala Ser Leu Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Ser Cys Arg Ala Ser Gln Asp Ile Ser Lys Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Asp Gly Thr Val Lys Leu Leu Ile 
        35                  40                  45              


Tyr His Thr Ser Arg Leu His Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Tyr Ser Leu Thr Ile Ser Asn Leu Glu Gln 
65                  70                  75                  80  


Glu Asp Ile Ala Thr Tyr Phe Cys Gln Gln Gly Asn Thr Leu Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  26
<211>  14
<212>  PRT
<213>  Saccharomyces cerevisiae

<400>  26

Asn Tyr His Leu Glu Asn Glu Val Ala Arg Leu Lys Lys Leu 
1               5                   10                  


<210>  27
<211>  126
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized light chain sequence

<400>  27

Asn Tyr His Leu Glu Asn Glu Val Ala Arg Leu Lys Lys Leu Gly Gly 
1               5                   10                  15      


Gly Gly Ser Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala 
            20                  25                  30          


Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Ile 
        35                  40                  45              


Ser Lys Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys 
    50                  55                  60                  


Leu Leu Ile Tyr His Thr Ser Arg Leu His Ser Gly Val Pro Ser Arg 
65                  70                  75                  80  


Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser 
                85                  90                  95      


Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Gly Asn Thr 
            100                 105                 110         


Leu Pro Tyr Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
        115                 120                 125     


<210>  28
<211>  126
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized light chain sequence

<400>  28

Asn Tyr His Leu Glu Asn Glu Val Ala Arg Leu Lys Lys Leu Gly Gly 
1               5                   10                  15      


Gly Gly Ser Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala 
            20                  25                  30          


Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Ile 
        35                  40                  45              


Ser Lys Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys 
    50                  55                  60                  


Leu Leu Ile Tyr His Thr Ser Arg Leu His Ser Gly Val Pro Ser Arg 
65                  70                  75                  80  


Phe Ser Gly Ser Gly Ser Gly Thr Asp Tyr Thr Leu Thr Ile Ser Ser 
                85                  90                  95      


Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Gly Ala Thr 
            100                 105                 110         


Leu Pro Tyr Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
        115                 120                 125     


<210>  29
<211>  126
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized light chain sequence

<400>  29

Asn Tyr His Leu Glu Asn Glu Val Ala Arg Leu Lys Lys Leu Gly Gly 
1               5                   10                  15      


Gly Gly Ser Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala 
            20                  25                  30          


Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Ile 
        35                  40                  45              


Ser Lys Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Val Lys 
    50                  55                  60                  


Leu Leu Ile Tyr His Thr Ser Arg Leu His Ser Gly Val Pro Ser Arg 
65                  70                  75                  80  


Phe Ser Gly Ser Gly Ser Gly Thr Asp Tyr Thr Leu Thr Ile Ser Ser 
                85                  90                  95      


Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Gly Ala Thr 
            100                 105                 110         


Leu Pro Tyr Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
        115                 120                 125     


<210>  30
<211>  126
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized light chain sequence

<400>  30

Asn Tyr His Leu Glu Asn Glu Val Ala Arg Leu Lys Lys Leu Gly Gly 
1               5                   10                  15      


Gly Gly Ser Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala 
            20                  25                  30          


Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Ile 
        35                  40                  45              


Ser Lys Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Val Lys 
    50                  55                  60                  


Leu Leu Ile Tyr His Thr Ser Arg Leu His Ser Gly Val Pro Ser Arg 
65                  70                  75                  80  


Phe Ser Gly Ser Gly Ser Gly Thr Asp Tyr Thr Leu Thr Ile Ser Ser 
                85                  90                  95      


Leu Gln Pro Glu Asp Phe Ala Thr Tyr Phe Cys Gln Gln Gly Ala Thr 
            100                 105                 110         


Leu Pro Tyr Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
        115                 120                 125     


<210>  31
<211>  126
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized light chain sequence

<400>  31

Asn Tyr His Leu Glu Asn Glu Val Ala Arg Leu Lys Lys Leu Gly Gly 
1               5                   10                  15      


Gly Gly Ser Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala 
            20                  25                  30          


Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Ile 
        35                  40                  45              


Ser Lys Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys 
    50                  55                  60                  


Leu Leu Ile Tyr His Thr Ser Arg Leu His Ser Gly Val Pro Ser Arg 
65                  70                  75                  80  


Phe Ser Gly Ser Gly Ser Gly Thr Asp Tyr Thr Leu Thr Ile Ser Ser 
                85                  90                  95      


Leu Gln Pro Glu Asp Phe Ala Thr Tyr Phe Cys Gln Gln Gly Ala Thr 
            100                 105                 110         


Leu Pro Tyr Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
        115                 120                 125     


<210>  32
<211>  126
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized light chain sequence

<400>  32

Asn Tyr His Leu Glu Asn Glu Val Ala Arg Leu Lys Lys Leu Gly Gly 
1               5                   10                  15      


Gly Gly Ser Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala 
            20                  25                  30          


Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Ile 
        35                  40                  45              


Ser Lys Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Leu Lys 
    50                  55                  60                  


Leu Leu Ile Tyr His Thr Ser Arg Leu His Ser Gly Val Pro Ser Arg 
65                  70                  75                  80  


Phe Ser Gly Ser Gly Ser Gly Thr Asp Tyr Thr Leu Thr Ile Ser Ser 
                85                  90                  95      


Leu Gln Pro Glu Asp Phe Ala Thr Tyr Phe Cys Gln Gln Gly Ala Thr 
            100                 105                 110         


Leu Pro Tyr Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
        115                 120                 125     


<210>  33
<211>  126
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized light chain sequence

<400>  33

Asn Tyr His Leu Glu Asn Glu Val Ala Arg Leu Lys Lys Leu Gly Gly 
1               5                   10                  15      


Gly Gly Ser Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala 
            20                  25                  30          


Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Ile 
        35                  40                  45              


Ser Lys Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Val Lys 
    50                  55                  60                  


Leu Leu Ile Tyr His Thr Ser Arg Leu His Ser Gly Val Pro Ser Arg 
65                  70                  75                  80  


Phe Ser Gly Ser Gly Ser Gly Thr Asp Tyr Thr Leu Thr Ile Ser Ser 
                85                  90                  95      


Leu Gln Pro Glu Asp Phe Ala Thr Tyr Phe Cys Gln Gln Gly Asn Thr 
            100                 105                 110         


Leu Pro Tyr Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
        115                 120                 125     


<210>  34
<211>  126
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized light chain sequence

<400>  34

Asn Tyr His Leu Glu Asn Glu Val Ala Arg Leu Lys Lys Leu Gly Gly 
1               5                   10                  15      


Gly Gly Ser Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala 
            20                  25                  30          


Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Ile 
        35                  40                  45              


Ser Lys Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Val Lys 
    50                  55                  60                  


Leu Leu Ile Tyr His Thr Ser Arg Leu His Ser Gly Val Pro Ser Arg 
65                  70                  75                  80  


Phe Ser Gly Ser Gly Ser Gly Thr Asp Tyr Thr Leu Thr Ile Ser Ser 
                85                  90                  95      


Leu Gln Pro Glu Asp Phe Ala Thr Tyr Phe Cys Gln Gln Gly Ala Thr 
            100                 105                 110         


Leu Pro Tyr Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
        115                 120                 125     


<210>  35
<211>  126
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized light chain sequence

<400>  35

Asn Tyr His Leu Glu Asn Glu Val Ala Arg Leu Lys Lys Leu Gly Gly 
1               5                   10                  15      


Gly Gly Ser Asp Ile Gln Met Thr Gln Thr Thr Ser Ser Leu Ser Ala 
            20                  25                  30          


Ser Leu Gly Asp Arg Val Thr Ile Ser Cys Arg Ala Ser Gln Asp Ile 
        35                  40                  45              


Ser Lys Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Asp Gly Thr Val Lys 
    50                  55                  60                  


Leu Leu Ile Tyr His Thr Ser Arg Leu His Ser Gly Val Pro Ser Arg 
65                  70                  75                  80  


Phe Ser Gly Ser Gly Ser Gly Thr Asp Tyr Ser Leu Thr Ile Ser Asn 
                85                  90                  95      


Leu Glu Gln Glu Asp Ile Ala Thr Tyr Phe Cys Gln Gln Gly Asn Thr 
            100                 105                 110         


Leu Pro Tyr Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
        115                 120                 125     


<210>  36
<211>  33
<212>  PRT
<213>  Saccharomyces cerevisiae

<400>  36

Arg Met Lys Gln Leu Glu Pro Lys Val Glu Glu Leu Leu Pro Lys Asn 
1               5                   10                  15      


Tyr His Leu Glu Asn Glu Val Ala Arg Leu Lys Lys Leu Val Gly Glu 
            20                  25                  30          


Arg 
    


<210>  37
<211>  24
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct - yeast transcription factor GCN4 truncated 
       binding peptide with linkers

<400>  37

Gly Gly Gly Gly Ser Asn Tyr His Leu Glu Asn Glu Val Ala Arg Leu 
1               5                   10                  15      


Lys Lys Leu Gly Gly Gly Gly Ser 
            20                  


<210>  38
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  38

Gly Gly Gly Gly Ser Asp Tyr Lys Asp Asp Asp Asp Lys 
1               5                   10              


<210>  39
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  39

Gly Gly Gly Gly Ser Asp Tyr Lys Asp Asp Asp Asp Lys Pro 
1               5                   10                  


<210>  40
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  40

Asp Tyr Lys Asp Asp Asp Asp Lys 
1               5               


<210>  41
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  41

Thr Asp Lys Asp Met Thr Ile Thr Phe Thr Asn Lys Lys Asp Ala Glu 
1               5                   10                  15      


<210>  42
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  42

Ala His Ile Val Met Val Asp Ala Tyr Lys Pro Thr Lys 
1               5                   10              


<210>  43
<211>  28
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  43

Lys Val Ala Ala Leu Lys Glu Lys Val Ala Ala Leu Lys Glu Lys Val 
1               5                   10                  15      


Ala Ala Leu Lys Glu Lys Val Ala Ala Leu Lys Glu 
            20                  25              


<210>  44
<211>  28
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  44

Glu Val Ala Ala Leu Glu Lys Glu Val Ala Ala Leu Glu Lys Glu Val 
1               5                   10                  15      


Ala Ala Leu Glu Lys Glu Val Ala Ala Leu Glu Lys 
            20                  25              


<210>  45
<211>  28
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  45

Glu Val Ser Ala Leu Glu Lys Glu Val Ser Ala Leu Glu Lys Glu Val 
1               5                   10                  15      


Ser Ala Leu Glu Lys Glu Val Ser Ala Leu Glu Lys 
            20                  25              


<210>  46
<211>  28
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  46

Lys Val Ser Ala Leu Lys Glu Lys Val Ser Ala Leu Lys Glu Lys Val 
1               5                   10                  15      


Ser Ala Leu Lys Glu Lys Val Ser Ala Leu Lys Glu 
            20                  25              


<210>  47
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  47

Glu Ile Ala Ala Leu Glu Lys Glu Ile Ala Ala Leu Glu Lys Glu Ile 
1               5                   10                  15      


Ala Ala Leu Glu Lys 
            20      


<210>  48
<211>  28
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  48

Glu Ile Ala Ala Leu Glu Lys Glu Ile Ala Ala Leu Glu Lys Glu Ile 
1               5                   10                  15      


Ala Ala Leu Glu Lys Glu Ile Ala Ala Leu Glu Lys 
            20                  25              


<210>  49
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  49

Lys Ile Ala Ala Leu Lys Glu Lys Ile Ala Ala Leu Lys Glu Lys Ile 
1               5                   10                  15      


Ala Ala Leu Lys Glu 
            20      


<210>  50
<211>  28
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  50

Lys Ile Ala Ala Leu Lys Glu Lys Ile Ala Ala Leu Lys Glu Lys Ile 
1               5                   10                  15      


Ala Ala Leu Lys Glu Lys Ile Ala Ala Leu Lys Glu 
            20                  25              


<210>  51
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  51

Glu Ile Ser Ala Leu Glu Lys Glu Ile Ser Ala Leu Glu Lys Glu Ile 
1               5                   10                  15      


Ser Ala Leu Glu Lys 
            20      


<210>  52
<211>  28
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  52

Glu Ile Ser Ala Leu Glu Lys Glu Ile Ser Ala Leu Glu Lys Glu Ile 
1               5                   10                  15      


Ser Ala Leu Glu Lys Glu Ile Ser Ala Leu Glu Lys 
            20                  25              


<210>  53
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  53

Lys Ile Ser Ala Leu Lys Glu Lys Ile Ser Ala Leu Lys Glu Lys Ile 
1               5                   10                  15      


Ser Ala Leu Lys Glu 
            20      


<210>  54
<211>  28
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  54

Lys Ile Ser Ala Leu Lys Glu Lys Ile Ser Ala Leu Lys Glu Lys Ile 
1               5                   10                  15      


Ser Ala Leu Lys Glu Lys Ile Ser Ala Leu Lys Glu 
            20                  25              


<210>  55
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  55

Glu Val Ala Ala Leu Glu Lys Glu Val Ala Ala Leu Glu Lys Glu Val 
1               5                   10                  15      


Ala Ala Leu Glu Lys 
            20      


<210>  56
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  56

Lys Val Ala Ala Leu Lys Glu Lys Val Ala Ala Leu Lys Glu Lys Val 
1               5                   10                  15      


Ala Ala Leu Lys Glu 
            20      


<210>  57
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  57

Glu Val Ser Ala Leu Glu Lys Glu Val Ser Ala Leu Glu Lys Glu Val 
1               5                   10                  15      


Ser Ala Leu Glu Lys 
            20      


<210>  58
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  58

Lys Val Ser Ala Leu Lys Glu Lys Val Ser Ala Leu Lys Glu Lys Val 
1               5                   10                  15      


Ser Ala Leu Lys Glu 
            20      


<210>  59
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  59

Gln Ile Glu Tyr Leu Ala Lys Gln Ile Val Asp Asn Ala Ile Gln Gln 
1               5                   10                  15      


Ala 
    


<210>  60
<211>  44
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  60

Ser His Ile Gln Ile Pro Pro Gly Leu Thr Glu Leu Leu Gln Gly Tyr 
1               5                   10                  15      


Thr Val Glu Val Leu Arg Gln Gln Pro Pro Asp Leu Val Glu Phe Ala 
            20                  25                  30          


Val Glu Tyr Phe Thr Arg Leu Arg Glu Ala Arg Ala 
        35                  40                  


<210>  61
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  61

Cys Gly Gln Ile Glu Tyr Leu Ala Lys Gln Ile Val Asp Asn Ala Ile 
1               5                   10                  15      


Gln Gln Ala Gly Cys 
            20      


<210>  62
<211>  45
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  62

Cys Gly His Ile Gln Ile Pro Pro Gly Leu Thr Glu Leu Leu Gln Gly 
1               5                   10                  15      


Tyr Thr Val Glu Val Leu Arg Gln Gln Pro Pro Asp Leu Val Glu Phe 
            20                  25                  30          


Ala Val Glu Tyr Phe Thr Arg Leu Arg Glu Ala Arg Ala 
        35                  40                  45  


<210>  63
<211>  8835
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic CAR construct

<400>  63
caggtggcac ttttcgggga aatgtgcgcg gaacccctat ttgtttattt ttctaaatac       60

attcaaatat gtatccgctc atgagacaat aaccctgata aatgcttcaa taatattgaa      120

aaaggaagag tatgagtatt caacatttcc gtgtcgccct tattcccttt tttgcggcat      180

tttgccttcc tgtttttgct cacccagaaa cgctggtgaa agtaaaagat gctgaagatc      240

agttgggtgc acgagtgggt tacatcgaac tggatctcaa cagcggtaag atccttgaga      300

gttttcgccc cgaagaacgt tttccaatga tgagcacttt taaagttctg ctatgtggcg      360

cggtattatc ccgtattgac gccgggcaag agcaactcgg tcgccgcata cactattctc      420

agaatgactt ggttgagtac tcaccagtca cagaaaagca tcttacggat ggcatgacag      480

taagagaatt atgcagtgct gccataacca tgagtgataa cactgcggcc aacttacttc      540

tgacaacgat cggaggaccg aaggagctaa ccgctttttt gcacaacatg ggggatcatg      600

taactcgcct tgatcgttgg gaaccggagc tgaatgaagc cataccaaac gacgagcgtg      660

acaccacgat gcctgtagca atggcaacaa cgttgcgcaa actattaact ggcgaactac      720

ttactctagc ttcccggcaa caattaatag actggatgga ggcggataaa gttgcaggac      780

cacttctgcg ctcggccctt ccggctggct ggtttattgc tgataaatct ggagccggtg      840

agcgtgggtc tcgcggtatc attgcagcac tggggccaga tggtaagccc tcccgtatcg      900

tagttatcta cacgacgggg agtcaggcaa ctatggatga acgaaataga cagatcgctg      960

agataggtgc ctcactgatt aagcattggt aactgtcaga ccaagtttac tcatatatac     1020

tttagattga tttaaaactt catttttaat ttaaaaggat ctaggtgaag atcctttttg     1080

ataatctcat gaccaaaatc ccttaacgtg agttttcgtt ccactgagcg tcagaccccg     1140

tagaaaagat caaaggatct tcttgagatc ctttttttct gcgcgtaatc tgctgcttgc     1200

aaacaaaaaa accaccgcta ccagcggtgg tttgtttgcc ggatcaagag ctaccaactc     1260

tttttccgaa ggtaactggc ttcagcagag cgcagatacc aaatactgtc cttctagtgt     1320

agccgtagtt aggccaccac ttcaagaact ctgtagcacc gcctacatac ctcgctctgc     1380

taatcctgtt accagtggct gctgccagtg gcgataagtc gtgtcttacc gggttggact     1440

caagacgata gttaccggat aaggcgcagc ggtcgggctg aacggggggt tcgtgcacac     1500

agcccagctt ggagcgaacg acctacaccg aactgagata cctacagcgt gagctatgag     1560

aaagcgccac gcttcccgaa gggagaaagg cggacaggta tccggtaagc ggcagggtcg     1620

gaacaggaga gcgcacgagg gagcttccag ggggaaacgc ctggtatctt tatagtcctg     1680

tcgggtttcg ccacctctga cttgagcgtc gatttttgtg atgctcgtca ggggggcgga     1740

gcctatggaa aaacgccagc aacgcggcct ttttacggtt cctggccttt tgctggcctt     1800

ttgctcacat gttctttcct gcgttatccc ctgattctgt ggataaccgt attaccgcct     1860

ttgagtgagc tgataccgct cgccgcagcc gaacgaccga gcgcagcgag tcagtgagcg     1920

aggaagcgga agagcgccca atacgcaaac cgcctctccc cgcgcgttgg ccgattcatt     1980

aatgcagctg gcacgacagg tttcccgact ggaaagcggg cagtgagcgc aacgcaatta     2040

atgtgagtta gctcactcat taggcacccc aggctttaca ctttatgctt ccggctcgta     2100

tgttgtgtgg aattgtgagc ggataacaat ttcacacagg aaacagctat gaccatgatt     2160

acgccaagcg cgcaattaac cctcactaaa gggaacaaaa gctggagctg caagcttaat     2220

gtagtcttat gcaatactct tgtagtcttg caacatggta acgatgagtt agcaacatgc     2280

cttacaagga gagaaaaagc accgtgcatg ccgattggtg gaagtaaggt ggtacgatcg     2340

tgccttatta ggaaggcaac agacgggtct gacatggatt ggacgaacca ctgaattgcc     2400

gcattgcaga gatattgtat ttaagtgcct agctcgatac aataaacggg tctctctggt     2460

tagaccagat ctgagcctgg gagctctctg gctaactagg gaacccactg cttaagcctc     2520

aataaagctt gccttgagtg cttcaagtag tgtgtgcccg tctgttgtgt gactctggta     2580

actagagatc cctcagaccc ttttagtcag tgtggaaaat ctctagcagt ggcgcccgaa     2640

cagggacctg aaagcgaaag ggaaaccaga gctctctcga cgcaggactc ggcttgctga     2700

agcgcgcacg gcaagaggcg aggggcggcg actggtgagt acgccaaaaa ttttgactag     2760

cggaggctag aaggagagag atgggtgcga gagcgtcagt attaagcggg ggagaattag     2820

atcgcgatgg gaaaaaattc ggttaaggcc agggggaaag aaaaaatata aattaaaaca     2880

tatagtatgg gcaagcaggg agctagaacg attcgcagtt aatcctggcc tgttagaaac     2940

atcagaaggc tgtagacaaa tactgggaca gctacaacca tcccttcaga caggatcaga     3000

agaacttaga tcattatata atacagtagc aaccctctat tgtgtgcatc aaaggataga     3060

gataaaagac accaaggaag ctttagacaa gatagaggaa gagcaaaaca aaagtaagac     3120

caccgcacag caagcggccg ctgatcttca gacctggagg aggagatatg agggacaatt     3180

ggagaagtga attatataaa tataaagtag taaaaattga accattagga gtagcaccca     3240

ccaaggcaaa gagaagagtg gtgcagagag aaaaaagagc agtgggaata ggagctttgt     3300

tccttgggtt cttgggagca gcaggaagca ctatgggcgc agcctcaatg acgctgacgg     3360

tacaggccag acaattattg tctggtatag tgcagcagca gaacaatttg ctgagggcta     3420

ttgaggcgca acagcatctg ttgcaactca cagtctgggg catcaagcag ctccaggcaa     3480

gaatcctggc tgtggaaaga tacctaaagg atcaacagct cctggggatt tggggttgct     3540

ctggaaaact catttgcacc actgctgtgc cttggaatgc tagttggagt aataaatctc     3600

tggaacagat tggaatcaca cgacctggat ggagtgggac agagaaatta acaattacac     3660

aagcttaata cactccttaa ttgaagaatc gcaaaaccag caagaaaaga atgaacaaga     3720

attattggaa ttagataaat gggcaagttt gtggaattgg tttaacataa caaattggct     3780

gtggtatata aaattattca taatgatagt aggaggcttg gtaggtttaa gaatagtttt     3840

tgctgtactt tctatagtga atagagttag gcagggatat tcaccattat cgtttcagac     3900

ccacctccca accccgaggg gacccgacag gcccgaagga atagaagaag aaggtggaga     3960

gagagacaga gacagatcca ttcgattagt gaacggatct cgacggttaa cttttaaaag     4020

aaaagggggg attggggggt acagtgcagg ggaaagaata gtagacataa tagcaacaga     4080

catacaaact aaagaattac aaaaacaaat tacaaaaatt caaaatttta tcgagctttg     4140

caaagatgga taaagtttta aacagagagg aatctttgca gctaatggac cttctaggtc     4200

ttgaaaggag tgcctcgtga ggctccggtg cccgtcagtg ggcagagcgc acatcgccca     4260

cagtccccga gaagttgggg ggaggggtcg gcaattgaac cggtgcctag agaaggtggc     4320

gcggggtaaa ctgggaaagt gatgtcgtgt actggctccg cctttttccc gagggtgggg     4380

gagaaccgta tataagtgca gtagtcgccg tgaacgttct ttttcgcaac gggtttgccg     4440

ccagaacaca ggtaagtgcc gtgtgtggtt cccgcgggcc tggcctcttt acgggttatg     4500

gcccttgcgt gccttgaatt acttccacct ggctgcagta cgtgattctt gatcccgagc     4560

ttcgggttgg aagtgggtgg gagagttcga ggccttgcgc ttaaggagcc ccttcgcctc     4620

gtgcttgagt tgaggcctgg cctgggcgct ggggccgccg cgtgcgaatc tggtggcacc     4680

ttcgcgcctg tctcgctgct ttcgataagt ctctagccat ttaaaatttt tgatgacctg     4740

ctgcgacgct ttttttctgg caagatagtc ttgtaaatgc gggccaagat ctgcacactg     4800

gtatttcggt ttttggggcc gcgggcggcg acggggcccg tgcgtcccag cgcacatgtt     4860

cggcgaggcg gggcctgcga gcgcggccac cgagaatcgg acgggggtag tctcaagctg     4920

gccggcctgc tctggtgcct ggcctcgcgc cgccgtgtat cgccccgccc tgggcggcaa     4980

ggctggcccg gtcggcacca gttgcgtgag cggaaagatg gccgcttccc ggccctgctg     5040

cagggagctc aaaatggagg acgcggcgct cgggagagcg ggcgggtgag tcacccacac     5100

aaaggaaaag ggcctttccg tcctcagccg tcgcttcatg tgactccacg gagtaccggg     5160

cgccgtccag gcacctcgat tagttctcga gcttttggag tacgtcgtct ttaggttggg     5220

gggaggggtt ttatgcgatg gagtttcccc acactgagtg ggtggagact gaagttaggc     5280

cagcttggca cttgatgtaa ttctccttgg aatttgccct ttttgagttt ggatcttggt     5340

tcattctcaa gcctcagaca gtggttcaaa gtttttttct tccatttcag gtgtcgtgag     5400

gaattcggta ccgcggccgc ccggggatcc atggccttac cagtgaccgc cttgctcctg     5460

ccgctggcct tgctgctcca cgccgccagg ccggacgccg ttgtgaccca ggaatccgct     5520

ctgacctctt ctccaggcga aaccgtgact ctgacttgcc gtagtagcac cggggctgtg     5580

accacatcta actatgccag ttgggtccag gaaaaaccgg atcacctgtt tactggcctg     5640

attggcggca ccaacaatcg cgcaccgggt gtgcccgctc gtttcagcgg ttccctgatt     5700

ggggacaagg cagcactgac tatcaccggc gcccagaccg aagatgaggc gatctatttt     5760

tgcgtcctgt ggtacagcga ccattgggtg ttcgggggag gcaccaaact gacagtgctg     5820

ggcggaggag gaggttcagg aggaggaggt agcgggggag gcggttccgg gggaggcggt     5880

tctgatgtgc agctgcaaga atccgggcca ggactggttg cgccttctca gagtctgtca     5940

attacatgta ctgttagtgg ctttctgctg accgactatg gtgtgaactg ggttcgtcag     6000

agcccaggca agggtctgga gtggctggga gtgatttggg gggatggaat cacagactac     6060

aatagcgcac tgaaatctcg gctgagtgtt accaaagata acagcaagtc ccaggtcttc     6120

ctgaagatga acagcctgca aagcggcgac tccgctcgct attactgcgt taccggactg     6180

tttgattatt gggggcaggg gacaactctg actgtttcct ccaccacgac gccagcgccg     6240

cgaccaccaa caccggcgcc caccatcgcg tcgcagcccc tgtccctgcg cccagaggcg     6300

tgccggccag cggcgggggg cgcagtgcac acgagggggc tggacttcgc ctgtgatatc     6360

tacatctggg cgcccttggc cgggacttgt ggggtccttc tcctgtcact ggttatcacc     6420

ctttactgca aacggggcag aaagaaactc ctgtatatat tcaaacaacc atttatgaga     6480

ccagtacaaa ctactcaaga ggaagatggc tgtagctgcc gatttccaga agaagaagaa     6540

ggaggatgtg aactgagagt gaagttcagc aggagcgcag acgcccccgc gtacaagcag     6600

ggccagaacc agctctataa cgagctcaat ctaggacgaa gagaggagta cgatgttttg     6660

gacaagagac gtggccggga ccctgagatg gggggaaagc cgagaaggaa gaaccctcag     6720

gaaggcctgt acaatgaact gcagaaagat aagatggcgg aggcctacag tgagattggg     6780

atgaaaggcg agcgccggag gggcaagggg cacgatggcc tttaccaggg tctcagtaca     6840

gccaccaagg acacctacga cgcccttcac atgcaggccc tgccccctcg ctaagtcgac     6900

aatcaacctc tggattacaa aatttgtgaa agattgactg gtattcttaa ctatgttgct     6960

ccttttacgc tatgtggata cgctgcttta atgcctttgt atcatgctat tgcttcccgt     7020

atggctttca ttttctcctc cttgtataaa tcctggttgc tgtctcttta tgaggagttg     7080

tggcccgttg tcaggcaacg tggcgtggtg tgcactgtgt ttgctgacgc aacccccact     7140

ggttggggca ttgccaccac ctgtcagctc ctttccggga ctttcgcttt ccccctccct     7200

attgccacgg cggaactcat cgccgcctgc cttgcccgct gctggacagg ggctcggctg     7260

ttgggcactg acaattccgt ggtgttgtcg gggaagctga cgtcctttcc atggctgctc     7320

gcctgtgttg ccacctggat tctgcgcggg acgtccttct gctacgtccc ttcggccctc     7380

aatccagcgg accttccttc ccgcggcctg ctgccggctc tgcggcctct tccgcgtctt     7440

cgccttcgcc ctcagacgag tcggatctcc ctttgggccg cctccccgcc tggaattcga     7500

gctcggtacc tttaagacca atgacttaca aggcagctgt agatcttagc cactttttaa     7560

aagaaaaggg gggactggaa gggctaattc actcccaacg aagacaagat ctgctttttg     7620

cttgtactgg gtctctctgg ttagaccaga tctgagcctg ggagctctct ggctaactag     7680

ggaacccact gcttaagcct caataaagct tgccttgagt gcttcaagta gtgtgtgccc     7740

gtctgttgtg tgactctggt aactagagat ccctcagacc cttttagtca gtgtggaaaa     7800

tctctagcag tagtagttca tgtcatctta ttattcagta tttataactt gcaaagaaat     7860

gaatatcaga gagtgagagg aacttgttta ttgcagctta taatggttac aaataaagca     7920

atagcatcac aaatttcaca aataaagcat ttttttcact gcattctagt tgtggtttgt     7980

ccaaactcat caatgtatct tatcatgtct ggctctagct atcccgcccc taactccgcc     8040

cagttccgcc cattctccgc cccatggctg actaattttt tttatttatg cagaggccga     8100

ggccgcctcg gcctctgagc tattccagaa gtagtgagga ggcttttttg gaggcctagg     8160

cttttgcgtc gagacgtacc caattcgccc tatagtgagt cgtattacgc gcgctcactg     8220

gccgtcgttt tacaacgtcg tgactgggaa aaccctggcg ttacccaact taatcgcctt     8280

gcagcacatc cccctttcgc cagctggcgt aatagcgaag aggcccgcac cgatcgccct     8340

tcccaacagt tgcgcagcct gaatggcgaa tggcgcgacg cgccctgtag cggcgcatta     8400

agcgcggcgg gtgtggtggt tacgcgcagc gtgaccgcta cacttgccag cgccctagcg     8460

cccgctcctt tcgctttctt cccttccttt ctcgccacgt tcgccggctt tccccgtcaa     8520

gctctaaatc gggggctccc tttagggttc cgatttagtg ctttacggca cctcgacccc     8580

aaaaaacttg attagggtga tggttcacgt agtgggccat cgccctgata gacggttttt     8640

cgccctttga cgttggagtc cacgttcttt aatagtggac tcttgttcca aactggaaca     8700

acactcaacc ctatctcggt ctattctttt gatttataag ggattttgcc gatttcggcc     8760

tattggttaa aaaatgagct gatttaacaa aaatttaacg cgaattttaa caaaatatta     8820

acgtttacaa tttcc                                                      8835


<210>  64
<211>  723
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  64
atggccttac cagtgaccgc cttgctcctg ccgctggcct tgctgctcca cgccgccagg       60

ccggaggttg ctgccctgga gaaggaggtg gctgcactgg agaaagaggt ggccgccctg      120

gaaaaagaag tggcagcctt ggagaaggaa agcaagtatg gcccaccttg tccaccttgt      180

cccgatatct acatctgggc gcccttggcc gggacttgtg gggtccttct cctgtcactg      240

gttatcaccc tttactgcaa acggggcaga aagaaactcc tgtatatatt caaacaacca      300

tttatgagac cagtacaaac tactcaagag gaagatggct gtagctgccg atttccagaa      360

gaagaagaag gaggatgtga actgagagtg aagttcagca ggagcgcaga cgcccccgcg      420

tacaagcagg gccagaacca gctctataac gagctcaatc taggacgaag agaggagtac      480

gatgttttgg acaagagacg tggccgggac cctgagatgg ggggaaagcc gagaaggaag      540

aaccctcagg aaggcctgta caatgaactg cagaaagata agatggcgga ggcctacagt      600

gagattggga tgaaaggcga gcgccggagg ggcaaggggc acgatggcct ttaccagggt      660

ctcagtacag ccaccaagga cacctacgac gcccttcaca tgcaggccct gccccctcgc      720

taa                                                                    723


<210>  65
<211>  723
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  65
atggccttac cagtgaccgc cttgctcctg ccgctggcct tgctgctcca cgccgccagg       60

ccgaaagtgg cagccctgaa ggagaaagtt gcggctctca aagagaaagt ggctgcactg      120

aaagaaaagg ttgccgccct caaggaggaa agcaagtatg gcccaccttg tccaccttgt      180

cccgatatct acatctgggc gcccttggcc gggacttgtg gggtccttct cctgtcactg      240

gttatcaccc tttactgcaa acggggcaga aagaaactcc tgtatatatt caaacaacca      300

tttatgagac cagtacaaac tactcaagag gaagatggct gtagctgccg atttccagaa      360

gaagaagaag gaggatgtga actgagagtg aagttcagca ggagcgcaga cgcccccgcg      420

tacaagcagg gccagaacca gctctataac gagctcaatc taggacgaag agaggagtac      480

gatgttttgg acaagagacg tggccgggac cctgagatgg ggggaaagcc gagaaggaag      540

aaccctcagg aaggcctgta caatgaactg cagaaagata agatggcgga ggcctacagt      600

gagattggga tgaaaggcga gcgccggagg ggcaaggggc acgatggcct ttaccagggt      660

ctcagtacag ccaccaagga cacctacgac gcccttcaca tgcaggccct gccccctcgc      720

taa                                                                    723


<210>  66
<211>  464
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic CAR construct

<400>  66

Asp Ile Val Met Thr Gln Thr Pro Leu Thr Leu Ser Val Thr Phe Gly 
1               5                   10                  15      


Gln Pro Ala Ser Ile Ser Cys Lys Ser Ser Gln Ser Leu Leu Asp Ser 
            20                  25                  30          


Asp Gly Gln Thr Tyr Leu Asn Trp Leu Leu Gln Arg Pro Gly Gln Ser 
        35                  40                  45              


Pro Lys Arg Leu Ile Tyr Leu Val Ser Lys Leu Asp Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Leu Gly Val Tyr Tyr Cys Trp Gln Gly 
                85                  90                  95      


Thr His Phe Pro Trp Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu 
        115                 120                 125             


Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Val Lys Pro Gly Ala Ser 
    130                 135                 140                 


Val Lys Leu Ser Cys Thr Ala Ser Gly Phe Asn Ile Lys Asp Tyr Tyr 
145                 150                 155                 160 


Met His Trp Val Lys Gln Arg Thr Glu Gln Gly Leu Glu Trp Ile Gly 
                165                 170                 175     


Arg Ile Asp Pro Glu Asp Gly Glu Thr Lys Tyr Ala Pro Lys Phe Gln 
            180                 185                 190         


Gly Lys Ala Thr Ile Thr Ala Asp Thr Ser Ser Lys Thr Ala Tyr Leu 
        195                 200                 205             


Gln Leu Ser Ser Leu Thr Ser Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
    210                 215                 220                 


Arg Leu Lys Gly Gly Tyr Trp Gly Gln Gly Thr Thr Leu Thr Val Ser 
225                 230                 235                 240 


Ser Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile 
                245                 250                 255     


Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala 
            260                 265                 270         


Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr 
        275                 280                 285             


Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu 
    290                 295                 300                 


Val Ile Thr Leu Tyr Cys Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile 
305                 310                 315                 320 


Phe Lys Gln Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp 
                325                 330                 335     


Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu 
            340                 345                 350         


Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Lys Gln Gly 
        355                 360                 365             


Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr 
    370                 375                 380                 


Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys 
385                 390                 395                 400 


Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys 
                405                 410                 415     


Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg 
            420                 425                 430         


Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala 
        435                 440                 445             


Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
    450                 455                 460                 


<210>  67
<211>  432
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic CAR construct

<400>  67

Asp Ile Val Met Thr Gln Thr Pro Leu Thr Leu Ser Val Thr Phe Gly 
1               5                   10                  15      


Gln Pro Ala Ser Ile Ser Cys Lys Ser Ser Gln Ser Leu Leu Asp Ser 
            20                  25                  30          


Asp Gly Gln Thr Tyr Leu Asn Trp Leu Leu Gln Arg Pro Gly Gln Ser 
        35                  40                  45              


Pro Lys Arg Leu Ile Tyr Leu Val Ser Lys Leu Asp Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Leu Gly Val Tyr Tyr Cys Trp Gln Gly 
                85                  90                  95      


Thr His Phe Pro Trp Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu 
        115                 120                 125             


Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Val Lys Pro Gly Ala Ser 
    130                 135                 140                 


Val Lys Leu Ser Cys Thr Ala Ser Gly Phe Asn Ile Lys Asp Tyr Tyr 
145                 150                 155                 160 


Met His Trp Val Lys Gln Arg Thr Glu Gln Gly Leu Glu Trp Ile Gly 
                165                 170                 175     


Arg Ile Asp Pro Glu Asp Gly Glu Thr Lys Tyr Ala Pro Lys Phe Gln 
            180                 185                 190         


Gly Lys Ala Thr Ile Thr Ala Asp Thr Ser Ser Lys Thr Ala Tyr Leu 
        195                 200                 205             


Gln Leu Ser Ser Leu Thr Ser Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
    210                 215                 220                 


Arg Leu Lys Gly Gly Tyr Trp Gly Gln Gly Thr Thr Leu Thr Val Ser 
225                 230                 235                 240 


Ser Glu Ser Lys Tyr Gly Pro Pro Cys Pro Pro Cys Pro Asp Ile Tyr 
                245                 250                 255     


Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu 
            260                 265                 270         


Val Ile Thr Leu Tyr Cys Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile 
        275                 280                 285             


Phe Lys Gln Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp 
    290                 295                 300                 


Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu 
305                 310                 315                 320 


Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Lys Gln Gly 
                325                 330                 335     


Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr 
            340                 345                 350         


Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys 
        355                 360                 365             


Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys 
    370                 375                 380                 


Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg 
385                 390                 395                 400 


Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala 
                405                 410                 415     


Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
            420                 425                 430         


<210>  68
<211>  1365
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic CAR construct

<400>  68
atggccttac cagtgaccgc cttgctcctg ccgctggcct tgctgctcca cgccgccagg       60

ccggacgccg ttgtgaccca ggaatccgct ctgacctctt ctccaggcga aaccgtgact      120

ctgacttgcc gtagtagcac cggggctgtg accacatcta actatgccag ttgggtccag      180

gaaaaaccgg atcacctgtt tactggcctg attggcggca ccaacaatcg cgcaccgggt      240

gtgcccgctc gtttcagcgg ttccctgatt ggggacaagg cagcactgac tatcaccggc      300

gcccagaccg aagatgaggc gatctatttt tgcgtcctgt ggtacagcga ccattgggtg      360

ttcgggggag gcaccaaact gacagtgctg ggcggaggag gaggttcagg aggaggaggt      420

agcgggggag gcggttccgg gggaggcggt tctgatgtgc agctgcaaga atccgggcca      480

ggactggttg cgccttctca gagtctgtca attacatgta ctgttagtgg ctttctgctg      540

accgactatg gtgtgaactg ggttcgtcag agcccaggca agggtctgga gtggctggga      600

gtgatttggg gggatggaat cacagactac aatagcgcac tgaaatctcg gctgagtgtt      660

accaaagata acagcaagtc ccaggtcttc ctgaagatga acagcctgca aagcggcgac      720

tccgctcgct attactgcgt taccggactg tttgattatt gggggcaggg gacaactctg      780

actgtttcct ccgaaagcaa gtatggccca ccttgtccaa gctgtcccga tatctacatc      840

tgggcgccct tggccgggac ttgtggggtc cttctcctgt cactggttat caccctttac      900

tgcaaacggg gcagaaagaa actcctgtat atattcaaac aaccatttat gagaccagta      960

caaactactc aagaggaaga tggctgtagc tgccgatttc cagaagaaga agaaggagga     1020

tgtgaactga gagtgaagtt cagcaggagc gcagacgccc ccgcgtacaa gcagggccag     1080

aaccagctct ataacgagct caatctagga cgaagagagg agtacgatgt tttggacaag     1140

agacgtggcc gggaccctga gatgggggga aagccgagaa ggaagaaccc tcaggaaggc     1200

ctgtacaatg aactgcagaa agataagatg gcggaggcct acagtgagat tgggatgaaa     1260

ggcgagcgcc ggaggggcaa ggggcacgat ggcctttacc agggtctcag tacagccacc     1320

aaggacacct acgacgccct tcacatgcag gccctgcccc ctcgc                     1365


<210>  69
<211>  1365
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic CAR construct

<400>  69
atggccttac cagtgaccgc cttgctcctg ccgctggcct tgctgctcca cgccgccagg       60

ccggacgccg ttgtgaccca ggaatccgct ctgacctctt ctccaggcga aaccgtgact      120

ctgacttgcc gtagtagcac cggggctgtg accacatcta actatgccag ttgggtccag      180

gaaaaaccgg atcacctgtt tactggcctg attggcggca ccaacaatcg cgcaccgggt      240

gtgcccgctc gtttcagcgg ttccctgatt ggggacaagg cagcactgac tatcaccggc      300

gcccagaccg aagatgaggc gatctatttt tgcgtcctgt ggtacagcga ccattgggtg      360

ttcgggggag gcaccaaact gacagtgctg ggcggaggag gaggttcagg aggaggaggt      420

agcgggggag gcggttccgg gggaggcggt tctgatgtgc agctgcaaga atccgggcca      480

ggactggttg cgccttctca gagtctgtca attacatgta ctgttagtgg ctttctgctg      540

accgactatg gtgtgaactg ggttcgtcag agcccaggca agggtctgga gtggctggga      600

gtgatttggg gggatggaat cacagactac aatagcgcac tgaaatctcg gctgagtgtt      660

accaaagata acagcaagtc ccaggtcttc ctgaagatga acagcctgca aagcggcgac      720

tccgctcgct attactgcgt taccggactg tttgattatt gggggcaggg gacaactctg      780

actgtttcct ccgaaagcaa gtatggccca ccttgtccac cttgtcccga tatctacatc      840

tgggcgccct tggccgggac ttgtggggtc cttctcctgt cactggttat caccctttac      900

tgcaaacggg gcagaaagaa actcctgtat atattcaaac aaccatttat gagaccagta      960

caaactactc aagaggaaga tggctgtagc tgccgatttc cagaagaaga agaaggagga     1020

tgtgaactga gagtgaagtt cagcaggagc gcagacgccc ccgcgtacaa gcagggccag     1080

aaccagctct ataacgagct caatctagga cgaagagagg agtacgatgt tttggacaag     1140

agacgtggcc gggaccctga gatgggggga aagccgagaa ggaagaaccc tcaggaaggc     1200

ctgtacaatg aactgcagaa agataagatg gcggaggcct acagtgagat tgggatgaaa     1260

ggcgagcgcc ggaggggcaa ggggcacgat ggcctttacc agggtctcag tacagccacc     1320

aaggacacct acgacgccct tcacatgcag gccctgcccc ctcgc                     1365


<210>  70
<211>  1443
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic CAR construct

<400>  70
atggccttac cagtgaccgc cttgctcctg ccgctggcct tgctgctcca cgccgccagg       60

ccgcaggcgg tagtcaccca ggagccaagt ctcacggtga gccccggcgg taccgtcaca      120

cttacatgcg gaagctctac cggggctgtg accacaagca actacgcatc ctgggtccag      180

cagaaacccg gtcaggctcc tcggggcctc attggtggga caaataacag agccccgggt      240

gttcccgccc gattttctgg cagtcttctg ggaggaaagg ccgctctgac aatatctggc      300

gcacagcccg aagacgaggc cgagtactat tgcgtgttgt ggtatagcga ccactgggta      360

ttcggtggag gaacaaagct gacagtgctc ggcggtggag ggagtggtgg cggtggcagc      420

ggagggggcg gatcacaagt gcaattgcag gagagtggac ctggactcgt gaaaccatct      480

gaaacactct ccctgacttg tacggtttca gggttcctgc tgacagacta tggagtaaac      540

tggatcaggc agccacccgg caagggcttg gagtggattg gcgtcatttg gggcgacgga      600

atcaccgact ataacccatc actcaaatct cgggtgacca tttccaagga taccagtaag      660

aatcagttca gcctgaaact ttcatccgtg acagctgcgg acaccgccgt gtactactgt      720

gtgacaggac tttttgacta ctggggccag gggaccctgg tgacagttag ctccaccacg      780

acgccagcgc cgcgaccacc aacaccggcg cccaccatcg cgtcgcagcc cctgtccctg      840

cgcccagagg cgtgccggcc agcggcgggg ggcgcagtgc acacgagggg gctggacttc      900

gcctgtgata tctacatctg ggcgcccttg gccgggactt gtggggtcct tctcctgtca      960

ctggttatca ccctttactg caaacggggc agaaagaaac tcctgtatat attcaaacaa     1020

ccatttatga gaccagtaca aactactcaa gaggaagatg gctgtagctg ccgatttcca     1080

gaagaagaag aaggaggatg tgaactgaga gtgaagttca gcaggagcgc agacgccccc     1140

gcgtacaagc agggccagaa ccagctctat aacgagctca atctaggacg aagagaggag     1200

tacgatgttt tggacaagag acgtggccgg gaccctgaga tggggggaaa gccgagaagg     1260

aagaaccctc aggaaggcct gtacaatgaa ctgcagaaag ataagatggc ggaggcctac     1320

agtgagattg ggatgaaagg cgagcgccgg aggggcaagg ggcacgatgg cctttaccag     1380

ggtctcagta cagccaccaa ggacacctac gacgcccttc acatgcaggc cctgccccct     1440

cgc                                                                   1443


<210>  71
<211>  1443
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic CAR construct

<400>  71
atggccttac cagtgaccgc cttgctcctg ccgctggcct tgctgctcca cgccgccagg       60

ccgcaggcgg tagtcaccca ggagccaagt ctcacggtga gccccggcgg taccgtcaca      120

cttacatgcg gaagctctac cggggctgtg accacaagca actacgcatc ctgggtccag      180

cagaaacccg gtcaggcgcc ccggggcctc attggtggga caaataacag agccccgggt      240

gttcccgccc gattttctgg cagtcttctg ggaggaaagg ccgctctgac aatatctggc      300

gcacagcccg aagacgaggc cgagtactat tgcgtgttgt ggtatagcga ccactgggta      360

ttcggtggag gaacaaagct gacagtgctc ggcggtggag ggagtggtgg cggtggcagc      420

ggagggggcg gatcacaagt gcaattgcag gagagtggac ctggactcgt gaaaccatct      480

gaaacactct ccataacttg tacggtttca gggttcctgc tgacagacta tggagtaaac      540

tgggttaggc agccacccgg caagggcttg gagtggctgg gcgtcatttg gggcgacgga      600

atcaccgact ataacccatc actcaaatct cggcttaccg tctccaagga tacgagtaag      660

aatcaggtca gcctgaaaat gtcatccctc acagctgcgg acaccgccgt gtactactgt      720

gtgacaggac tttttgacta ctggggccag gggaccctgc tcacagttag ctccaccacg      780

acgccagcgc cgcgaccacc aacaccggcg cccaccatcg cgtcgcagcc cctgtccctg      840

cgcccagagg cgtgccggcc agcggcgggg ggcgcagtgc acacgagggg gctggacttc      900

gcctgtgata tctacatctg ggcgcccttg gccgggactt gtggggtcct tctcctgtca      960

ctggttatca ccctttactg caaacggggc agaaagaaac tcctgtatat attcaaacaa     1020

ccatttatga gaccagtaca aactactcaa gaggaagatg gctgtagctg ccgatttcca     1080

gaagaagaag aaggaggatg tgaactgaga gtgaagttca gcaggagcgc agacgccccc     1140

gcgtacaagc agggccagaa ccagctctat aacgagctca atctaggacg aagagaggag     1200

tacgatgttt tggacaagag acgtggccgg gaccctgaga tggggggaaa gccgagaagg     1260

aagaaccctc aggaaggcct gtacaatgaa ctgcagaaag ataagatggc ggaggcctac     1320

agtgagattg ggatgaaagg cgagcgccgg aggggcaagg ggcacgatgg cctttaccag     1380

ggtctcagta cagccaccaa ggacacctac gacgcccttc acatgcaggc cctgccccct     1440

cgc                                                                   1443


<210>  72
<211>  1443
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic CAR construct

<400>  72
atggccttac cagtgaccgc cttgctcctg ccgctggcct tgctgctcca cgccgccagg       60

ccgcaggcgg tagtcaccca ggagccaagt ctcacggtga gccccggcgg taccgtcaca      120

cttacatgcg gaagctctac cggggctgtg accacaagca actacgcatc ctgggtccag      180

cagaaacccg gacaagcgtt ccggggcctc attggtggga caaataacag agccccgggt      240

gttcccgccc gattttctgg cagtcttctg ggaggaaagg ccgctctgac aatatctggc      300

gcacagcccg aagacgaggc cgagtactat tgcgtgttgt ggtatagcga ccactgggta      360

ttcggtggag gaacaaagct gacagtgctc ggcggtggag ggagtggtgg cggtggcagc      420

ggagggggcg gatcacaagt gcaattgcag gagagtggac ctggactcgt gaaaccatct      480

gaaacactct ccctcacttg tacggtttca gggttcctgc tgacagacta tggagtaaac      540

tggattaggc agccacccgg caagggcttg gagtggatcg gcgtcatttg gggcgacgga      600

atcaccgact ataacccatc actcaaatct cgggtcacca tctccaagga taccagtaag      660

aatcagttca gcctgaaact gtcatccgtc acagctgcgg acaccgccgt gtactactgt      720

gtgacaggac tttttgacta ctggggccag gggaccctgg taacagttag ctccaccacg      780

acgccagcgc cgcgaccacc aacaccggcg cccaccatcg cgtcgcagcc cctgtccctg      840

cgcccagagg cgtgccggcc agcggcgggg ggcgcagtgc acacgagggg gctggacttc      900

gcctgtgata tctacatctg ggcgcccttg gccgggactt gtggggtcct tctcctgtca      960

ctggttatca ccctttactg caaacggggc agaaagaaac tcctgtatat attcaaacaa     1020

ccatttatga gaccagtaca aactactcaa gaggaagatg gctgtagctg ccgatttcca     1080

gaagaagaag aaggaggatg tgaactgaga gtgaagttca gcaggagcgc agacgccccc     1140

gcgtacaagc agggccagaa ccagctctat aacgagctca atctaggacg aagagaggag     1200

tacgatgttt tggacaagag acgtggccgg gaccctgaga tggggggaaa gccgagaagg     1260

aagaaccctc aggaaggcct gtacaatgaa ctgcagaaag ataagatggc ggaggcctac     1320

agtgagattg ggatgaaagg cgagcgccgg aggggcaagg ggcacgatgg cctttaccag     1380

ggtctcagta cagccaccaa ggacacctac gacgcccttc acatgcaggc cctgccccct     1440

cgc                                                                   1443


<210>  73
<211>  1443
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic CAR construct

<400>  73
atggccttac cagtgaccgc cttgctcctg ccgctggcct tgctgctcca cgccgccagg       60

ccgcaggcgg tagtcaccca ggagccaagt ctcacggtga gccccggcgg taccgtcaca      120

cttacatgcg gaagctctac cggggctgtg accacaagca actacgcatc ctgggtccag      180

cagaaacccg gtcaggcatt ccggggcctc attggtggga caaataacag agccccgggt      240

gttcccgccc gattttctgg cagtcttctg ggaggaaagg ccgctctgac aatatctggc      300

gcacagcccg aagacgaggc cgagtactat tgcgtgttgt ggtatagcga ccactgggta      360

ttcggtggag gaacaaagct gacagtgctc ggcggtggag ggagtggtgg cggtggcagc      420

ggagggggcg gatcacaagt gcaattgcag gagagtggac ctggactcgt gaaaccatct      480

gaaacactct ccataacttg tacggtttca gggttcctgc tgacagacta tggagtaaac      540

tgggtcaggc agccacccgg caagggcttg gagtggctcg gcgtcatttg gggcgacgga      600

atcaccgact ataacccatc actcaaatct cggttgaccg tgtccaagga taccagtaag      660

aatcaggtca gcctgaaaat gtcatccctg acagctgcgg acaccgccgt gtactactgt      720

gtgacaggac tttttgacta ctggggccag gggaccctgt tgacagttag ctccaccacg      780

acgccagcgc cgcgaccacc aacaccggcg cccaccatcg cgtcgcagcc cctgtccctg      840

cgcccagagg cgtgccggcc agcggcgggg ggcgcagtgc acacgagggg gctggacttc      900

gcctgtgata tctacatctg ggcgcccttg gccgggactt gtggggtcct tctcctgtca      960

ctggttatca ccctttactg caaacggggc agaaagaaac tcctgtatat attcaaacaa     1020

ccatttatga gaccagtaca aactactcaa gaggaagatg gctgtagctg ccgatttcca     1080

gaagaagaag aaggaggatg tgaactgaga gtgaagttca gcaggagcgc agacgccccc     1140

gcgtacaagc agggccagaa ccagctctat aacgagctca atctaggacg aagagaggag     1200

tacgatgttt tggacaagag acgtggccgg gaccctgaga tggggggaaa gccgagaagg     1260

aagaaccctc aggaaggcct gtacaatgaa ctgcagaaag ataagatggc ggaggcctac     1320

agtgagattg ggatgaaagg cgagcgccgg aggggcaagg ggcacgatgg cctttaccag     1380

ggtctcagta cagccaccaa ggacacctac gacgcccttc acatgcaggc cctgccccct     1440

cgc                                                                   1443


<210>  74
<211>  1443
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic CAR construct

<400>  74
atggccttac cagtgaccgc cttgctcctg ccgctggcct tgctgctcca cgccgccagg       60

ccgcaggcgg tagtcaccca ggagccaagt ctcacggtga gccccggcgg taccgtcaca      120

cttacatgcg gaagctctac cggggctgtg accacaagca actacgcatc ctgggtccag      180

cagaaacccg atcacctgtt ccggggcctc attggtggga caaataacag agccccgggt      240

gttcccgccc gattttctgg cagtcttctg ggaggaaagg ccgctctgac aatatctggc      300

gcacagcccg aagacgaggc cgagtactat tgcgtgttgt ggtatagcga ccactgggta      360

ttcggtggag gaacaaagct gacagtgctc ggcggtggag ggagtggtgg cggtggcagc      420

ggagggggcg gatcacaagt gcaattgcag gagagtggac ctggactcgt gaaaccatct      480

gaaacactct cccttacttg tacggtttca gggttcctgc tgacagacta tggagtaaac      540

tggatcaggc agccacccgg caagggcttg gagtggatcg gcgtcatttg gggcgacgga      600

atcaccgact ataacccatc actcaaatct cgggtcacca tctccaagga tacgagtaag      660

aatcagttca gcctgaaact ctcatccgtt acagctgcgg acaccgccgt gtactactgt      720

gtgacaggac tttttgacta ctggggccag gggaccctgg taacagttag ctccaccacg      780

acgccagcgc cgcgaccacc aacaccggcg cccaccatcg cgtcgcagcc cctgtccctg      840

cgcccagagg cgtgccggcc agcggcgggg ggcgcagtgc acacgagggg gctggacttc      900

gcctgtgata tctacatctg ggcgcccttg gccgggactt gtggggtcct tctcctgtca      960

ctggttatca ccctttactg caaacggggc agaaagaaac tcctgtatat attcaaacaa     1020

ccatttatga gaccagtaca aactactcaa gaggaagatg gctgtagctg ccgatttcca     1080

gaagaagaag aaggaggatg tgaactgaga gtgaagttca gcaggagcgc agacgccccc     1140

gcgtacaagc agggccagaa ccagctctat aacgagctca atctaggacg aagagaggag     1200

tacgatgttt tggacaagag acgtggccgg gaccctgaga tggggggaaa gccgagaagg     1260

aagaaccctc aggaaggcct gtacaatgaa ctgcagaaag ataagatggc ggaggcctac     1320

agtgagattg ggatgaaagg cgagcgccgg aggggcaagg ggcacgatgg cctttaccag     1380

ggtctcagta cagccaccaa ggacacctac gacgcccttc acatgcaggc cctgccccct     1440

cgc                                                                   1443


<210>  75
<211>  1443
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic CAR construct

<400>  75
atggccttac cagtgaccgc cttgctcctg ccgctggcct tgctgctcca cgccgccagg       60

ccgcaggcgg tagtcaccca ggagccaagt ctcacggtga gccccggcgg taccgtcaca      120

cttacatgcg gaagctctac cggggctgtg accacaagca actacgcatc ctgggtccag      180

cagaaacccg accatctgtt tcggggcctc attggtggga caaataacag agccccgggt      240

gttcccgccc gattttctgg cagtcttctg ggaggaaagg ccgctctgac aatatctggc      300

gcacagcccg aagacgaggc cgagtactat tgcgtgttgt ggtatagcga ccactgggta      360

ttcggtggag gaacaaagct gacagtgctc ggcggtggag ggagtggtgg cggtggcagc      420

ggagggggcg gatcacaagt gcaattgcag gagagtggac ctggactcgt gaaaccatct      480

gaaacactct ccattacttg tacggtttca gggttcctgc tgacagacta tggagtaaac      540

tgggtgaggc agccacccgg caagggcttg gagtggctcg gcgtcatttg gggcgacgga      600

atcaccgact ataacccatc actcaaatct cggttgaccg tgtccaagga taccagtaag      660

aatcaggtga gcctgaaaat gtcatccctg acagctgcgg acaccgccgt gtactactgt      720

gtgacaggac tttttgacta ctggggccag gggaccctgc tgacagttag ctccaccacg      780

acgccagcgc cgcgaccacc aacaccggcg cccaccatcg cgtcgcagcc cctgtccctg      840

cgcccagagg cgtgccggcc agcggcgggg ggcgcagtgc acacgagggg gctggacttc      900

gcctgtgata tctacatctg ggcgcccttg gccgggactt gtggggtcct tctcctgtca      960

ctggttatca ccctttactg caaacggggc agaaagaaac tcctgtatat attcaaacaa     1020

ccatttatga gaccagtaca aactactcaa gaggaagatg gctgtagctg ccgatttcca     1080

gaagaagaag aaggaggatg tgaactgaga gtgaagttca gcaggagcgc agacgccccc     1140

gcgtacaagc agggccagaa ccagctctat aacgagctca atctaggacg aagagaggag     1200

tacgatgttt tggacaagag acgtggccgg gaccctgaga tggggggaaa gccgagaagg     1260

aagaaccctc aggaaggcct gtacaatgaa ctgcagaaag ataagatggc ggaggcctac     1320

agtgagattg ggatgaaagg cgagcgccgg aggggcaagg ggcacgatgg cctttaccag     1380

ggtctcagta cagccaccaa ggacacctac gacgcccttc acatgcaggc cctgccccct     1440

cgc                                                                   1443


<210>  76
<211>  1461
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic CAR construct

<400>  76
atggccttac cagtgaccgc cttgctcctg ccgctggcct tgctgctcca cgccgccagg       60

ccggacgccg ttgtgaccca ggaatccgct ctgacctctt ctccaggcga aaccgtgact      120

ctgacttgcc gtagtagcac cggggctgtg accacatcta actatgccag ttgggtccag      180

gaaaaaccgg atcacctgtt tactggcctg attggcggca ccaacaatcg cgcaccgggt      240

gtgcccgctc gtttcagcgg ttccctgatt ggggacaagg cagcactgac tatcaccggc      300

gcccagaccg aagatgaggc gatctatttt tgcgtcctgt ggtacagcga ccattgggtg      360

ttcgggggag gcaccaaact gacagtgctg ggcggaggag gaggttcagg aggaggaggt      420

agcgggggag gcggttccgg gggaggcggt tctgatgtgc agctgcaaga atccgggcca      480

ggactggttg cgccttctca gagtctgtca attacatgta ctgttagtgg ctttctgctg      540

accgactatg gtgtgaactg ggttcgtcag agcccaggca agggtctgga gtggctggga      600

gtgatttggg gggatggaat cacagactac aatagcgcac tgaaatctcg gctgagtgtt      660

accaaagata acagcaagtc ccaggtcttc ctgaagatga acagcctgca aagcggcgac      720

tccgctcgct attactgcgt taccggactg tttgattatt gggggcaggg gacaactctg      780

actgtttcct ccaccacgac gccagcgccg cgaccaccaa caccggcgcc caccatcgcg      840

tcgcagcccc tgtccctgcg cccagaggcg tgccggccag cggcgggggg cgcagtgcac      900

acgagggggc tggacttcgc ctgtgatatc tacatctggg cgcccttggc cgggacttgt      960

ggggtccttc tcctgtcact ggttatcacc ctttactgca aacggggcag aaagaaactc     1020

ctgtatatat tcaaacaacc atttatgaga ccagtacaaa ctactcaaga ggaagatggc     1080

tgtagctgcc gatttccaga agaagaagaa ggaggatgtg aactgagagt gaagttcagc     1140

aggagcgcag acgcccccgc gtacaagcag ggccagaacc agctctataa cgagctcaat     1200

ctaggacgaa gagaggagta cgatgttttg gacaagagac gtggccggga ccctgagatg     1260

gggggaaagc cgagaaggaa gaaccctcag gaaggcctgt acaatgaact gcagaaagat     1320

aagatggcgg aggcctacag tgagattggg atgaaaggcg agcgccggag gggcaagggg     1380

cacgatggcc tttaccaggg tctcagtaca gccaccaagg acacctacga cgcccttcac     1440

atgcaggccc tgccccctcg c                                               1461


<210>  77
<211>  1329
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic CAR construct

<400>  77
atggccttac cagtgaccgc cttgctcctg ccgctggcct tgctgctcca cgccgccagg       60

ccggacgccg ttgtgaccca ggaatccgct ctgacctctt ctccaggcga aaccgtgact      120

ctgacttgcc gtagtagcac cggggctgtg accacatcta actatgccag ttgggtccag      180

gaaaaaccgg atcacctgtt tactggcctg attggcggca ccaacaatcg cgcaccgggt      240

gtgcccgctc gtttcagcgg ttccctgatt ggggacaagg cagcactgac tatcaccggc      300

gcccagaccg aagatgaggc gatctatttt tgcgtcctgt ggtacagcga ccattgggtg      360

ttcgggggag gcaccaaact gacagtgctg ggcggaggag gaggttcagg aggaggaggt      420

agcgggggag gcggttccgg gggaggcggt tctgatgtgc agctgcaaga atccgggcca      480

ggactggttg cgccttctca gagtctgtca attacatgta ctgttagtgg ctttctgctg      540

accgactatg gtgtgaactg ggttcgtcag agcccaggca agggtctgga gtggctggga      600

gtgatttggg gggatggaat cacagactac aatagcgcac tgaaatctcg gctgagtgtt      660

accaaagata acagcaagtc ccaggtcttc ctgaagatga acagcctgca aagcggcgac      720

tccgctcgct attactgcgt taccggactg tttgattatt gggggcaggg gacaactctg      780

actgtttcct ccgatatcta catctgggcg cccttggccg ggacttgtgg ggtccttctc      840

ctgtcactgg ttatcaccct ttactgcaaa cggggcagaa agaaactcct gtatatattc      900

aaacaaccat ttatgagacc agtacaaact actcaagagg aagatggctg tagctgccga      960

tttccagaag aagaagaagg aggatgtgaa ctgagagtga agttcagcag gagcgcagac     1020

gcccccgcgt acaagcaggg ccagaaccag ctctataacg agctcaatct aggacgaaga     1080

gaggagtacg atgttttgga caagagacgt ggccgggacc ctgagatggg gggaaagccg     1140

agaaggaaga accctcagga aggcctgtac aatgaactgc agaaagataa gatggcggag     1200

gcctacagtg agattgggat gaaaggcgag cgccggaggg gcaaggggca cgatggcctt     1260

taccagggtc tcagtacagc caccaaggac acctacgacg cccttcacat gcaggccctg     1320

ccccctcgc                                                             1329


<210>  78
<211>  1374
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic CAR construct

<400>  78
atgggtgtcc ctacccagct cctgggactg ctcctgctgt ggatcaccga cgccatctgc       60

gacgccgttg tgacccagga atccgctctg acctcttctc caggcgaaac cgtgactctg      120

acttgccgta gtagcaccgg ggctgtgacc acatctaact atgccagttg ggtccaggaa      180

aaaccggatc acctgtttac tggcctgatt ggcggcacca acaatcgcgc accgggtgtg      240

cccgctcgtt tcagcggttc cctgattggg gacaaggcag cactgactat caccggcgcc      300

cagaccgaag atgaggcgat ctatttttgc gtcctgtggt acagcgacca ttgggtgttc      360

gggggaggca ccaaactgac agtgctgggc ggaggaggag gttcaggagg aggaggtagc      420

gggggaggcg gttccggggg aggcggttct gatgtgcagc tgcaagaatc cgggccagga      480

ctggttgcgc cttctcagag tctgtcaatt acatgtactg ttagtggctt tctgctgacc      540

gactatggtg tgaactgggt tcgtcagagc ccaggcaagg gtctggagtg gctgggagtg      600

atttgggggg atggaatcac agactacaat agcgcactga aatctcggct gagtgttacc      660

aaagataaca gcaagtccca ggtcttcctg aagatgaatt ccctgcaaag cggcgactcc      720

gctcgctatt actgcgttac cggactgttt gattattggg ggcaggggac aactctgact      780

gtttcctccg aaagcaagta tggcccacct tgtccacctt gtcccattta catctgggca      840

cccttggccg gaatctgcgt ggcccttctg ctgtccttga tcatcactct catctgcaaa      900

tggatcagga aaaaattccc ccacatattc aagcaaccat ttaagaagac cactggagca      960

gctcaagagg aagatgcttg tagctgccga tgtccacagg aagaagaagg aggaggagga     1020

ggctatgagc tgagagccaa gttcagcaga tccgccgaga cagccgccaa cctgcaggat     1080

cccaaccagc tgttcaacga gctgaacctg ggcagacggg aggaattcga cgtgctggaa     1140

aagaagagag ccagggaccc cgagatgggc ggcaagcagc agagaagaag aaaccctcag     1200

gaaggcgtct acaacgccct gcagaaagac aagatggccg aggcctacag cgagatcggc     1260

accaagggcg agagaagaag gggcaagggc cacgatggcc tgttccaggg cctgtccacc     1320

gccaccaagg acaccttcga cgccctgcac atgcagaccc tggcccccag atga           1374


<210>  79
<211>  1374
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic CAR construct

<400>  79
atgggtgtcc ctacccagct cctgggactg ctcctgctgt ggatcaccga cgccatctgc       60

gacgccgttg tgacccagga atccgctctg acctcttctc caggcgaaac cgtgactctg      120

acttgccgta gtagcaccgg ggctgtgacc acatctaact atgccagttg ggtccaggaa      180

aaaccggatc acctgtttac tggcctgatt ggcggcacca acaatcgcgc accgggtgtg      240

cccgctcgtt tcagcggttc cctgattggg gacaaggcag cactgactat caccggcgcc      300

cagaccgaag atgaggcgat ctatttttgc gtcctgtggt acagcgacca ttgggtgttc      360

gggggaggca ccaaactgac agtgctgggc ggaggaggag gttcaggagg aggaggtagc      420

gggggaggcg gttccggggg aggcggttct gatgtgcagc tgcaagaatc cgggccagga      480

ctggttgcgc cttctcagag tctgtcaatt acatgtactg ttagtggctt tctgctgacc      540

gactatggtg tgaactgggt tcgtcagagc ccaggcaagg gtctggagtg gctgggagtg      600

atttgggggg atggaatcac agactacaat agcgcactga aatctcggct gagtgttacc      660

aaagataaca gcaagtccca ggtcttcctg aagatgaatt ccctgcaaag cggcgactcc      720

gctcgctatt actgcgttac cggactgttt gattattggg ggcaggggac aactctgact      780

gtttcctccg aaagcaagta tggcccacct tgtccacctt gtcccattta catctgggca      840

cccttggccg gaatctgcgt ggcccttctg ctgtccttga tcatcactct catctgcaaa      900

tggatcagga aaaaattccc ccacatattc aagcaaccat ttaagaagac cactggagca      960

gctcaagagg aagatgcttg tagctgccga tgtccacagg aagaagaagg aggaggagga     1020

ggctatgagc tgagagcaaa attcagcagg agtgcagaga ctgctgccaa cctgcaggac     1080

cccaaccagc tctacaatga gctcaatcta gggcgaagag aggaatatga cgtcttggag     1140

aagaagcggg ctcgggatcc agagatggga ggcaaacagc agaggaggag gaacccccag     1200

gaaggcgtat acaatgcact gcagaaagac aagatggcag aagcctacag tgagatcggc     1260

acaaaaggcg agaggcggag aggcaagggg cacgatggcc tttaccaggg tctcagcact     1320

gccaccaagg acacctatga tgccctgcat atgcagaccc tggcccctcg ctaa           1374


<210>  80
<211>  1467
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic CAR construct

<400>  80
atgggtgtcc ctacccagct cctgggactg ctcctgctgt ggatcaccga cgccatctgc       60

gacgccgttg tgacccagga atccgctctg acctcttctc caggcgaaac cgtgactctg      120

acttgccgta gtagcaccgg ggctgtgacc acatctaact atgccagttg ggtccaggaa      180

aaaccggatc acctgtttac tggcctgatt ggcggcacca acaatcgcgc accgggtgtg      240

cccgctcgtt tcagcggttc cctgattggg gacaaggcag cactgactat caccggcgcc      300

cagaccgaag atgaggcgat ctatttttgc gtcctgtggt acagcgacca ttgggtgttc      360

gggggaggca ccaaactgac agtgctgggc ggaggaggag gttcaggagg aggaggtagc      420

gggggaggcg gttccggggg aggcggttct gatgtgcagc tgcaagaatc cgggccagga      480

ctggttgcgc cttctcagag tctgtcaatt acatgtactg ttagtggctt tctgctgacc      540

gactatggtg tgaactgggt tcgtcagagc ccaggcaagg gtctggagtg gctgggagtg      600

atttgggggg atggaatcac agactacaat agcgcactga aatctcggct gagtgttacc      660

aaagataaca gcaagtccca ggtcttcctg aagatgaatt ccctgcaaag cggcgactcc      720

gctcgctatt actgcgttac cggactgttt gattattggg ggcaggggac aactctgact      780

gtttcctcca ctactaccaa gccagtgctg cgaactccct cacctgtgca ccctaccggg      840

acatctcagc cccagagacc agaagattgt cggccccgtg gctcagtgaa ggggaccgga      900

ttggacttcg cctgtgatat ttacatctgg gcacccttgg ccggaatctg cgtggccctt      960

ctgctgtcct tgatcatcac tctcatctgc aaatggatca ggaaaaaatt cccccacata     1020

ttcaagcaac catttaagaa gaccactgga gcagctcaag aggaagatgc ttgtagctgc     1080

cgatgtccac aggaagaaga aggaggagga ggaggctatg agctgagagc caagttcagc     1140

agatccgccg agacagccgc caacctgcag gatcccaacc agctgttcaa cgagctgaac     1200

ctgggcagac gggaggaatt cgacgtgctg gaaaagaaga gagccaggga ccccgagatg     1260

ggcggcaagc agcagagaag aagaaaccct caggaaggcg tctacaacgc cctgcagaaa     1320

gacaagatgg ccgaggccta cagcgagatc ggcaccaagg gcgagagaag aaggggcaag     1380

ggccacgatg gcctgttcca gggcctgtcc accgccacca aggacacctt cgacgccctg     1440

cacatgcaga ccctggcccc cagatga                                         1467


<210>  81
<211>  1467
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic CAR construct

<400>  81
atgggtgtcc ctacccagct cctgggactg ctcctgctgt ggatcaccga cgccatctgc       60

gacgccgttg tgacccagga atccgctctg acctcttctc caggcgaaac cgtgactctg      120

acttgccgta gtagcaccgg ggctgtgacc acatctaact atgccagttg ggtccaggaa      180

aaaccggatc acctgtttac tggcctgatt ggcggcacca acaatcgcgc accgggtgtg      240

cccgctcgtt tcagcggttc cctgattggg gacaaggcag cactgactat caccggcgcc      300

cagaccgaag atgaggcgat ctatttttgc gtcctgtggt acagcgacca ttgggtgttc      360

gggggaggca ccaaactgac agtgctgggc ggaggaggag gttcaggagg aggaggtagc      420

gggggaggcg gttccggggg aggcggttct gatgtgcagc tgcaagaatc cgggccagga      480

ctggttgcgc cttctcagag tctgtcaatt acatgtactg ttagtggctt tctgctgacc      540

gactatggtg tgaactgggt tcgtcagagc ccaggcaagg gtctggagtg gctgggagtg      600

atttgggggg atggaatcac agactacaat agcgcactga aatctcggct gagtgttacc      660

aaagataaca gcaagtccca ggtcttcctg aagatgaatt ccctgcaaag cggcgactcc      720

gctcgctatt actgcgttac cggactgttt gattattggg ggcaggggac aactctgact      780

gtttcctcca ctactaccaa gccagtgctg cgaactccct cacctgtgca ccctaccggg      840

acatctcagc cccagagacc agaagattgt cggccccgtg gctcagtgaa ggggaccgga      900

ttggacttcg cctgtgatat ttacatctgg gcacccttgg ccggaatctg cgtggccctt      960

ctgctgtcct tgatcatcac tctcatctgc aaatggatca ggaaaaaatt cccccacata     1020

ttcaagcaac catttaagaa gaccactgga gcagctcaag aggaagatgc ttgtagctgc     1080

cgatgtccac aggaagaaga aggaggagga ggaggctatg agctgagagc aaaattcagc     1140

aggagtgcag agactgctgc caacctgcag gaccccaacc agctctacaa tgagctcaat     1200

ctagggcgaa gagaggaata tgacgtcttg gagaagaagc gggctcggga tccagagatg     1260

ggaggcaaac agcagaggag gaggaacccc caggaaggcg tatacaatgc actgcagaaa     1320

gacaagatgg cagaagccta cagtgagatc ggcacaaaag gcgagaggcg gagaggcaag     1380

gggcacgatg gcctttacca gggtctcagc actgccacca aggacaccta tgatgccctg     1440

catatgcaga ccctggcccc tcgctaa                                         1467


<210>  82
<211>  1371
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic CAR construct

<400>  82
atgggtgtcc ctacccagct cctgggactg ctcctgctgt ggatcaccga cgccatctgc       60

gacgccgttg tgacccagga atccgctctg acctcttctc caggcgaaac cgtgactctg      120

acttgccgta gtagcaccgg ggctgtgacc acatctaact atgccagttg ggtccaggaa      180

aaaccggatc acctgtttac tggcctgatt ggcggcacca acaatcgcgc accgggtgtg      240

cccgctcgtt tcagcggttc cctgattggg gacaaggcag cactgactat caccggcgcc      300

cagaccgaag atgaggcgat ctatttttgc gtcctgtggt acagcgacca ttgggtgttc      360

gggggaggca ccaaactgac agtgctgggc ggaggaggag gttcaggagg aggaggtagc      420

gggggaggcg gttccggggg aggcggttct gatgtgcagc tgcaagaatc cgggccagga      480

ctggttgcgc cttctcagag tctgtcaatt acatgtactg ttagtggctt tctgctgacc      540

gactatggtg tgaactgggt tcgtcagagc ccaggcaagg gtctggagtg gctgggagtg      600

atttgggggg atggaatcac agactacaat agcgcactga aatctcggct gagtgttacc      660

aaagataaca gcaagtccca ggtcttcctg aagatgaaca gcctgcaaag cggcgactcc      720

gctcgctatt actgcgttac cggactgttt gattattggg ggcaggggac aactctgact      780

gtttcctccg aaagcaagta tggcccacct tgtccacctt gtcccttctg ggccctggtg      840

gtggtggccg gcgtgctgtt ctgttacggc ctgctggtca cagtggccct gtgcgtgatc      900

tggaccaaca gcagaagaaa cagaggcggc cagagcgact acatgaacat gacccccaga      960

aggccaggcc tgaccagaaa gccctaccag ccctacgccc ctgccagaga cttcgccgcc     1020

tacagaccca gagccaagtt cagcagatcc gccgagacag ccgccaacct gcaggatccc     1080

aaccagctgt tcaacgagct gaacctgggc agacgggagg aattcgacgt gctggaaaag     1140

aagagagcca gggaccccga gatgggcggc aagcagcaga gaagaagaaa ccctcaggaa     1200

ggcgtctaca acgccctgca gaaagacaag atggccgagg cctacagcga gatcggcacc     1260

aagggcgaga gaagaagggg caagggccac gatggcctgt tccagggcct gtccaccgcc     1320

accaaggaca ccttcgacgc cctgcacatg cagaccctgg cccccagatg a              1371


<210>  83
<211>  1371
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic CAR construct

<400>  83
atgggtgtcc ctacccagct cctgggactg ctcctgctgt ggatcaccga cgccatctgc       60

gatgtgcagc tgcaagaatc cgggccagga ctggttgcgc cttctcagag tctgtcaatt      120

acatgtactg ttagtggctt tctgctgacc gactatggtg tgaactgggt tcgtcagagc      180

ccaggcaagg gtctggagtg gctgggagtg atttgggggg atggaatcac agactacaat      240

agcgcactga aatctcggct gagtgttacc aaagataaca gcaagtccca ggtcttcctg      300

aagatgaaca gcctgcaaag cggcgactcc gctcgctatt actgcgttac cggactgttt      360

gattattggg ggcaggggac aactctgact gtttcctccg gaggaggagg ttcaggagga      420

ggaggtagcg ggggaggcgg ttccggggga ggcggttctg acgccgttgt gacccaggaa      480

tccgctctga cctcttctcc aggcgaaacc gtgactctga cttgccgtag tagcaccggg      540

gctgtgacca catctaacta tgccagttgg gtccaggaaa aaccggatca cctgtttact      600

ggcctgattg gcggcaccaa caatcgcgca ccgggtgtgc ccgctcgttt cagcggttcc      660

ctgattgggg acaaggcagc actgactatc accggcgccc agaccgaaga tgaggcgatc      720

tatttttgcg tcctgtggta cagcgaccat tgggtgttcg ggggaggcac caaactgaca      780

gtgctgggcg aaagcaagta tggcccacct tgtccacctt gtcccttctg ggccctggtg      840

gtggtggccg gcgtgctgtt ctgttacggc ctgctggtca cagtggccct gtgcgtgatc      900

tggaccaaca gcagaagaaa cagaggcggc cagagcgact acatgaacat gacccccaga      960

aggccaggcc tgaccagaaa gccctaccag ccctacgccc ctgccagaga cttcgccgcc     1020

tacagaccca gagccaagtt cagcagatcc gccgagacag ccgccaacct gcaggatccc     1080

aaccagctgt tcaacgagct gaacctgggc agacgggagg aattcgacgt gctggaaaag     1140

aagagagcca gggaccccga gatgggcggc aagcagcaga gaagaagaaa ccctcaggaa     1200

ggcgtctaca acgccctgca gaaagacaag atggccgagg cctacagcga gatcggcacc     1260

aagggcgaga gaagaagggg caagggccac gatggcctgt tccagggcct gtccaccgcc     1320

accaaggaca ccttcgacgc cctgcacatg cagaccctgg cccccagatg a              1371


<210>  84
<211>  1365
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic CAR construct

<400>  84
atgggtgtcc ctacccagct cctgggactg ctcctgctgt ggatcaccga cgccatctgc       60

gacgccgttg tgacccagga atccgctctg acctcttctc caggcgaaac cgtgactctg      120

acttgccgta gtagcaccgg ggctgtgacc acatctaact atgccagttg ggtccaggaa      180

aaaccggatc acctgtttac tggcctgatt ggcggcacca acaatcgcgc accgggtgtg      240

cccgctcgtt tcagcggttc cctgattggg gacaaggcag cactgactat caccggcgcc      300

cagaccgaag atgaggcgat ctatttttgc gtcctgtggt acagcgacca ttgggtgttc      360

gggggaggca ccaaactgac agtgctgggc ggaggaggag gttcaggagg aggaggtagc      420

gggggaggcg gttccggggg aggcggttct gatgtgcagc tgcaagaatc cgggccagga      480

ctggttgcgc cttctcagag tctgtcaatt acatgtactg ttagtggctt tctgctgacc      540

gactatggtg tgaactgggt tcgtcagagc ccaggcaagg gtctggagtg gctgggagtg      600

atttgggggg atggaatcac agactacaat agcgcactga aatctcggct gagtgttacc      660

aaagataaca gcaagtccca ggtcttcctg aagatgaaca gcctgcaaag cggcgactcc      720

gctcgctatt actgcgttac cggactgttt gattattggg ggcaggggac aactctgact      780

gtttcctccg aaagcaagta tggcccacct tgtccacctt gtcccgatat ctacatctgg      840

gcgcccttgg ccgggacttg tggggtcctt ctcctgtcac tggttatcac cctttactgc      900

aaacggggca gaaagaaact cctgtatata ttcaaacaac catttatgag accagtacaa      960

actactcaag aggaagatgg ctgtagctgc cgatttccag aagaagaaga aggaggatgt     1020

gaactgagag tgaagttcag caggagcgca gacgcccccg cgtacaagca gggccagaac     1080

cagctctata acgagctcaa tctaggacga agagaggagt acgatgtttt ggacaagaga     1140

cgtggccggg accctgagat ggggggaaag ccgagaagga agaaccctca ggaaggcctg     1200

tacaatgaac tgcagaaaga taagatggcg gaggcctaca gtgagattgg gatgaaaggc     1260

gagcgccgga ggggcaaggg gcacgatggc ctttaccagg gtctcagtac agccaccaag     1320

gacacctacg acgcccttca catgcaggcc ctgccccctc gctaa                     1365


<210>  85
<211>  326
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic CAR construct


<220>
<221>  misc_feature
<222>  (27)..(27)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (41)..(42)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (123)..(123)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (141)..(141)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (152)..(152)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (159)..(159)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (262)..(262)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (264)..(265)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (286)..(286)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (289)..(289)
<223>  n is a, c, g, or t

<400>  85
davvtsatss gtvttcrsst gavttsnyas wvkdhtgggt nnragvarsg sgdkaattga       60

tdaycvwysd hwvgggtktv gggggsgggg sggggsgggg sdvsggvass stctvsgtdy      120

gvnwvrsgkg wgvwgdgtdy nsaksrsvtk dnsksvkmns sgdsaryycv tgdywggttt      180

vsstttarta tassracraa ggavhtrgda cdywaagtcg vsvtyckrgr kkykmrvttd      240

gcscrggcrv ksrsadaayk gnynngrryd vdkrrgrdmg gkrrkngynk dkmaaysgmk      300

grrrgkghdg ygstatkdty dahmar                                           326


<210>  86
<211>  304
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic CAR construct


<220>
<221>  misc_feature
<222>  (27)..(27)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (41)..(42)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (123)..(123)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (141)..(141)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (152)..(152)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (159)..(159)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (240)..(240)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (242)..(243)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (264)..(264)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (267)..(267)
<223>  n is a, c, g, or t

<400>  86
davvtsatss gtvttcrsst gavttsnyas wvkdhtgggt nnragvarsg sgdkaattga       60

tdaycvwysd hwvgggtktv gggggsgggg sggggsgggg sdvsggvass stctvsgtdy      120

gvnwvrsgkg wgvwgdgtdy nsaksrsvtk dnsksvkmns sgdsaryycv tgdywggttt      180

vssskygccd ywaagtcgvs vtyckrgrkk ykmrvttdgc scrggcrvks rsadaaykgn      240

ynngrrydvd krrgrdmggk rrkngynkdk maaysgmkgr rrgkghdgyg statkdtyda      300

hmar                                                                   304


<210>  87
<211>  8892
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic CAR construct

<400>  87
caggtggcac ttttcgggga aatgtgcgcg gaacccctat ttgtttattt ttctaaatac       60

attcaaatat gtatccgctc atgagacaat aaccctgata aatgcttcaa taatattgaa      120

aaaggaagag tatgagtatt caacatttcc gtgtcgccct tattcccttt tttgcggcat      180

tttgccttcc tgtttttgct cacccagaaa cgctggtgaa agtaaaagat gctgaagatc      240

agttgggtgc acgagtgggt tacatcgaac tggatctcaa cagcggtaag atccttgaga      300

gttttcgccc cgaagaacgt tttccaatga tgagcacttt taaagttctg ctatgtggcg      360

cggtattatc ccgtattgac gccgggcaag agcaactcgg tcgccgcata cactattctc      420

agaatgactt ggttgagtac tcaccagtca cagaaaagca tcttacggat ggcatgacag      480

taagagaatt atgcagtgct gccataacca tgagtgataa cactgcggcc aacttacttc      540

tgacaacgat cggaggaccg aaggagctaa ccgctttttt gcacaacatg ggggatcatg      600

taactcgcct tgatcgttgg gaaccggagc tgaatgaagc cataccaaac gacgagcgtg      660

acaccacgat gcctgtagca atggcaacaa cgttgcgcaa actattaact ggcgaactac      720

ttactctagc ttcccggcaa caattaatag actggatgga ggcggataaa gttgcaggac      780

cacttctgcg ctcggccctt ccggctggct ggtttattgc tgataaatct ggagccggtg      840

agcgtgggtc tcgcggtatc attgcagcac tggggccaga tggtaagccc tcccgtatcg      900

tagttatcta cacgacgggg agtcaggcaa ctatggatga acgaaataga cagatcgctg      960

agataggtgc ctcactgatt aagcattggt aactgtcaga ccaagtttac tcatatatac     1020

tttagattga tttaaaactt catttttaat ttaaaaggat ctaggtgaag atcctttttg     1080

ataatctcat gaccaaaatc ccttaacgtg agttttcgtt ccactgagcg tcagaccccg     1140

tagaaaagat caaaggatct tcttgagatc ctttttttct gcgcgtaatc tgctgcttgc     1200

aaacaaaaaa accaccgcta ccagcggtgg tttgtttgcc ggatcaagag ctaccaactc     1260

tttttccgaa ggtaactggc ttcagcagag cgcagatacc aaatactgtc cttctagtgt     1320

agccgtagtt aggccaccac ttcaagaact ctgtagcacc gcctacatac ctcgctctgc     1380

taatcctgtt accagtggct gctgccagtg gcgataagtc gtgtcttacc gggttggact     1440

caagacgata gttaccggat aaggcgcagc ggtcgggctg aacggggggt tcgtgcacac     1500

agcccagctt ggagcgaacg acctacaccg aactgagata cctacagcgt gagctatgag     1560

aaagcgccac gcttcccgaa gggagaaagg cggacaggta tccggtaagc ggcagggtcg     1620

gaacaggaga gcgcacgagg gagcttccag ggggaaacgc ctggtatctt tatagtcctg     1680

tcgggtttcg ccacctctga cttgagcgtc gatttttgtg atgctcgtca ggggggcgga     1740

gcctatggaa aaacgccagc aacgcggcct ttttacggtt cctggccttt tgctggcctt     1800

ttgctcacat gttctttcct gcgttatccc ctgattctgt ggataaccgt attaccgcct     1860

ttgagtgagc tgataccgct cgccgcagcc gaacgaccga gcgcagcgag tcagtgagcg     1920

aggaagcgga agagcgccca atacgcaaac cgcctctccc cgcgcgttgg ccgattcatt     1980

aatgcagctg gcacgacagg tttcccgact ggaaagcggg cagtgagcgc aacgcaatta     2040

atgtgagtta gctcactcat taggcacccc aggctttaca ctttatgctt ccggctcgta     2100

tgttgtgtgg aattgtgagc ggataacaat ttcacacagg aaacagctat gaccatgatt     2160

acgccaagcg cgcaattaac cctcactaaa gggaacaaaa gctggagctg caagcttaat     2220

gtagtcttat gcaatactct tgtagtcttg caacatggta acgatgagtt agcaacatgc     2280

cttacaagga gagaaaaagc accgtgcatg ccgattggtg gaagtaaggt ggtacgatcg     2340

tgccttatta ggaaggcaac agacgggtct gacatggatt ggacgaacca ctgaattgcc     2400

gcattgcaga gatattgtat ttaagtgcct agctcgatac aataaacggg tctctctggt     2460

tagaccagat ctgagcctgg gagctctctg gctaactagg gaacccactg cttaagcctc     2520

aataaagctt gccttgagtg cttcaagtag tgtgtgcccg tctgttgtgt gactctggta     2580

actagagatc cctcagaccc ttttagtcag tgtggaaaat ctctagcagt ggcgcccgaa     2640

cagggacctg aaagcgaaag ggaaaccaga gctctctcga cgcaggactc ggcttgctga     2700

agcgcgcacg gcaagaggcg aggggcggcg actggtgagt acgccaaaaa ttttgactag     2760

cggaggctag aaggagagag atgggtgcga gagcgtcagt attaagcggg ggagaattag     2820

atcgcgatgg gaaaaaattc ggttaaggcc agggggaaag aaaaaatata aattaaaaca     2880

tatagtatgg gcaagcaggg agctagaacg attcgcagtt aatcctggcc tgttagaaac     2940

atcagaaggc tgtagacaaa tactgggaca gctacaacca tcccttcaga caggatcaga     3000

agaacttaga tcattatata atacagtagc aaccctctat tgtgtgcatc aaaggataga     3060

gataaaagac accaaggaag ctttagacaa gatagaggaa gagcaaaaca aaagtaagac     3120

caccgcacag caagcggccg ctgatcttca gacctggagg aggagatatg agggacaatt     3180

ggagaagtga attatataaa tataaagtag taaaaattga accattagga gtagcaccca     3240

ccaaggcaaa gagaagagtg gtgcagagag aaaaaagagc agtgggaata ggagctttgt     3300

tccttgggtt cttgggagca gcaggaagca ctatgggcgc agcctcaatg acgctgacgg     3360

tacaggccag acaattattg tctggtatag tgcagcagca gaacaatttg ctgagggcta     3420

ttgaggcgca acagcatctg ttgcaactca cagtctgggg catcaagcag ctccaggcaa     3480

gaatcctggc tgtggaaaga tacctaaagg atcaacagct cctggggatt tggggttgct     3540

ctggaaaact catttgcacc actgctgtgc cttggaatgc tagttggagt aataaatctc     3600

tggaacagat tggaatcaca cgacctggat ggagtgggac agagaaatta acaattacac     3660

aagcttaata cactccttaa ttgaagaatc gcaaaaccag caagaaaaga atgaacaaga     3720

attattggaa ttagataaat gggcaagttt gtggaattgg tttaacataa caaattggct     3780

gtggtatata aaattattca taatgatagt aggaggcttg gtaggtttaa gaatagtttt     3840

tgctgtactt tctatagtga atagagttag gcagggatat tcaccattat cgtttcagac     3900

ccacctccca accccgaggg gacccgacag gcccgaagga atagaagaag aaggtggaga     3960

gagagacaga gacagatcca ttcgattagt gaacggatct cgacggttaa cttttaaaag     4020

aaaagggggg attggggggt acagtgcagg ggaaagaata gtagacataa tagcaacaga     4080

catacaaact aaagaattac aaaaacaaat tacaaaaatt caaaatttta tcgagctttg     4140

caaagatgga taaagtttta aacagagagg aatctttgca gctaatggac cttctaggtc     4200

ttgaaaggag tgcctcgtga ggctccggtg cccgtcagtg ggcagagcgc acatcgccca     4260

cagtccccga gaagttgggg ggaggggtcg gcaattgaac cggtgcctag agaaggtggc     4320

gcggggtaaa ctgggaaagt gatgtcgtgt actggctccg cctttttccc gagggtgggg     4380

gagaaccgta tataagtgca gtagtcgccg tgaacgttct ttttcgcaac gggtttgccg     4440

ccagaacaca ggtaagtgcc gtgtgtggtt cccgcgggcc tggcctcttt acgggttatg     4500

gcccttgcgt gccttgaatt acttccacct ggctgcagta cgtgattctt gatcccgagc     4560

ttcgggttgg aagtgggtgg gagagttcga ggccttgcgc ttaaggagcc ccttcgcctc     4620

gtgcttgagt tgaggcctgg cctgggcgct ggggccgccg cgtgcgaatc tggtggcacc     4680

ttcgcgcctg tctcgctgct ttcgataagt ctctagccat ttaaaatttt tgatgacctg     4740

ctgcgacgct ttttttctgg caagatagtc ttgtaaatgc gggccaagat ctgcacactg     4800

gtatttcggt ttttggggcc gcgggcggcg acggggcccg tgcgtcccag cgcacatgtt     4860

cggcgaggcg gggcctgcga gcgcggccac cgagaatcgg acgggggtag tctcaagctg     4920

gccggcctgc tctggtgcct ggcctcgcgc cgccgtgtat cgccccgccc tgggcggcaa     4980

ggctggcccg gtcggcacca gttgcgtgag cggaaagatg gccgcttccc ggccctgctg     5040

cagggagctc aaaatggagg acgcggcgct cgggagagcg ggcgggtgag tcacccacac     5100

aaaggaaaag ggcctttccg tcctcagccg tcgcttcatg tgactccacg gagtaccggg     5160

cgccgtccag gcacctcgat tagttctcga gcttttggag tacgtcgtct ttaggttggg     5220

gggaggggtt ttatgcgatg gagtttcccc acactgagtg ggtggagact gaagttaggc     5280

cagcttggca cttgatgtaa ttctccttgg aatttgccct ttttgagttt ggatcttggt     5340

tcattctcaa gcctcagaca gtggttcaaa gtttttttct tccatttcag gtgtcgtgag     5400

gaattcggta ccgcggccgc ccggggatcc atggccttac cagtgaccgc cttgctcctg     5460

ccgctggcct tgctgctcca cgccgccagg ccggatgttg ttatgaccca gaccccgctg     5520

tccctgcccg tttccctggg tgaccaggcg agtatctctt gccgttcctc tcagtccctg     5580

gttcacagtc agggtaacac ctatctgcgc tggtatctgc aaaaaccagg ccagagccct     5640

aaagtgctga tttataaggt ttcaaatcgg tttagcggcg tcccggatcg cttctctggg     5700

agtggatcag ggaccgactt tacactgaaa attagccgcg tggaagcaga ggatctgggc     5760

gtgtactttt gcagccagtc cactcatgtg ccgtggacct tcggcggtgg gacaaaactg     5820

gaaattaagc gtgcaggagg cggtgggagc ggaggcggtg ggtccggagg cggtgggtct     5880

ggaggcggtg ggagtggagg cggtgggtca ggcggtggtg ggagcgaagt gaaactggat     5940

gagacaggag gaggtctggt tcagccaggt cggcccatga agctgtcctg tgtggcctct     6000

ggctttacct tctccgacta ttggatgaac tgggtccgtc agtctccgga aaaaggtctg     6060

gagtgggtgg cgcagattcg gaacaagccc tacaactacg aaacttacta ctctgatagt     6120

gttaaaggcc gcttcaccat cagtcgtgat gactcaaaaa gcagcgttta cctgcaaatg     6180

aacaatctgc gtgtcgagga catgggcatc tattactgca caggctccta ctatgggatg     6240

gattattggg ggcaggggac ttcagttaca gtttcctcaa ccacgacgcc agcgccgcga     6300

ccaccaacac cggcgcccac catcgcgtcg cagcccctgt ccctgcgccc agaggcgtgc     6360

cggccagcgg cggggggcgc agtgcacacg agggggctgg acttcgcctg tgatatctac     6420

atctgggcgc ccttggccgg gacttgtggg gtccttctcc tgtcactggt tatcaccctt     6480

tactgcaaac ggggcagaaa gaaactcctg tatatattca aacaaccatt tatgagacca     6540

gtacaaacta ctcaagagga agatggctgt agctgccgat ttccagaaga agaagaagga     6600

ggatgtgaac tgagagtgaa gttcagcagg agcgcagacg cccccgcgta caagcagggc     6660

cagaaccagc tctataacga gctcaatcta ggacgaagag aggagtacga tgttttggac     6720

aagagacgtg gccgggaccc tgagatgggg ggaaagccga gaaggaagaa ccctcaggaa     6780

ggcctgtaca atgaactgca gaaagataag atggcggagg cctacagtga gattgggatg     6840

aaaggcgagc gccggagggg caaggggcac gatggccttt accagggtct cagtacagcc     6900

accaaggaca cctacgacgc ccttcacatg caggccctgc cccctcgcta agtcgacaat     6960

caacctctgg attacaaaat ttgtgaaaga ttgactggta ttcttaacta tgttgctcct     7020

tttacgctat gtggatacgc tgctttaatg cctttgtatc atgctattgc ttcccgtatg     7080

gctttcattt tctcctcctt gtataaatcc tggttgctgt ctctttatga ggagttgtgg     7140

cccgttgtca ggcaacgtgg cgtggtgtgc actgtgtttg ctgacgcaac ccccactggt     7200

tggggcattg ccaccacctg tcagctcctt tccgggactt tcgctttccc cctccctatt     7260

gccacggcgg aactcatcgc cgcctgcctt gcccgctgct ggacaggggc tcggctgttg     7320

ggcactgaca attccgtggt gttgtcgggg aagctgacgt cctttccatg gctgctcgcc     7380

tgtgttgcca cctggattct gcgcgggacg tccttctgct acgtcccttc ggccctcaat     7440

ccagcggacc ttccttcccg cggcctgctg ccggctctgc ggcctcttcc gcgtcttcgc     7500

cttcgccctc agacgagtcg gatctccctt tgggccgcct ccccgcctgg aattcgagct     7560

cggtaccttt aagaccaatg acttacaagg cagctgtaga tcttagccac tttttaaaag     7620

aaaagggggg actggaaggg ctaattcact cccaacgaag acaagatctg ctttttgctt     7680

gtactgggtc tctctggtta gaccagatct gagcctggga gctctctggc taactaggga     7740

acccactgct taagcctcaa taaagcttgc cttgagtgct tcaagtagtg tgtgcccgtc     7800

tgttgtgtga ctctggtaac tagagatccc tcagaccctt ttagtcagtg tggaaaatct     7860

ctagcagtag tagttcatgt catcttatta ttcagtattt ataacttgca aagaaatgaa     7920

tatcagagag tgagaggaac ttgtttattg cagcttataa tggttacaaa taaagcaata     7980

gcatcacaaa tttcacaaat aaagcatttt tttcactgca ttctagttgt ggtttgtcca     8040

aactcatcaa tgtatcttat catgtctggc tctagctatc ccgcccctaa ctccgcccag     8100

ttccgcccat tctccgcccc atggctgact aatttttttt atttatgcag aggccgaggc     8160

cgcctcggcc tctgagctat tccagaagta gtgaggaggc ttttttggag gcctaggctt     8220

ttgcgtcgag acgtacccaa ttcgccctat agtgagtcgt attacgcgcg ctcactggcc     8280

gtcgttttac aacgtcgtga ctgggaaaac cctggcgtta cccaacttaa tcgccttgca     8340

gcacatcccc ctttcgccag ctggcgtaat agcgaagagg cccgcaccga tcgcccttcc     8400

caacagttgc gcagcctgaa tggcgaatgg cgcgacgcgc cctgtagcgg cgcattaagc     8460

gcggcgggtg tggtggttac gcgcagcgtg accgctacac ttgccagcgc cctagcgccc     8520

gctcctttcg ctttcttccc ttcctttctc gccacgttcg ccggctttcc ccgtcaagct     8580

ctaaatcggg ggctcccttt agggttccga tttagtgctt tacggcacct cgaccccaaa     8640

aaacttgatt agggtgatgg ttcacgtagt gggccatcgc cctgatagac ggtttttcgc     8700

cctttgacgt tggagtccac gttctttaat agtggactct tgttccaaac tggaacaaca     8760

ctcaacccta tctcggtcta ttcttttgat ttataaggga ttttgccgat ttcggcctat     8820

tggttaaaaa atgagctgat ttaacaaaaa tttaacgcga attttaacaa aatattaacg     8880

tttacaattt cc                                                         8892


<210>  88
<211>  8892
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic CAR construct

<400>  88
caggtggcac ttttcgggga aatgtgcgcg gaacccctat ttgtttattt ttctaaatac       60

attcaaatat gtatccgctc atgagacaat aaccctgata aatgcttcaa taatattgaa      120

aaaggaagag tatgagtatt caacatttcc gtgtcgccct tattcccttt tttgcggcat      180

tttgccttcc tgtttttgct cacccagaaa cgctggtgaa agtaaaagat gctgaagatc      240

agttgggtgc acgagtgggt tacatcgaac tggatctcaa cagcggtaag atccttgaga      300

gttttcgccc cgaagaacgt tttccaatga tgagcacttt taaagttctg ctatgtggcg      360

cggtattatc ccgtattgac gccgggcaag agcaactcgg tcgccgcata cactattctc      420

agaatgactt ggttgagtac tcaccagtca cagaaaagca tcttacggat ggcatgacag      480

taagagaatt atgcagtgct gccataacca tgagtgataa cactgcggcc aacttacttc      540

tgacaacgat cggaggaccg aaggagctaa ccgctttttt gcacaacatg ggggatcatg      600

taactcgcct tgatcgttgg gaaccggagc tgaatgaagc cataccaaac gacgagcgtg      660

acaccacgat gcctgtagca atggcaacaa cgttgcgcaa actattaact ggcgaactac      720

ttactctagc ttcccggcaa caattaatag actggatgga ggcggataaa gttgcaggac      780

cacttctgcg ctcggccctt ccggctggct ggtttattgc tgataaatct ggagccggtg      840

agcgtgggtc tcgcggtatc attgcagcac tggggccaga tggtaagccc tcccgtatcg      900

tagttatcta cacgacgggg agtcaggcaa ctatggatga acgaaataga cagatcgctg      960

agataggtgc ctcactgatt aagcattggt aactgtcaga ccaagtttac tcatatatac     1020

tttagattga tttaaaactt catttttaat ttaaaaggat ctaggtgaag atcctttttg     1080

ataatctcat gaccaaaatc ccttaacgtg agttttcgtt ccactgagcg tcagaccccg     1140

tagaaaagat caaaggatct tcttgagatc ctttttttct gcgcgtaatc tgctgcttgc     1200

aaacaaaaaa accaccgcta ccagcggtgg tttgtttgcc ggatcaagag ctaccaactc     1260

tttttccgaa ggtaactggc ttcagcagag cgcagatacc aaatactgtc cttctagtgt     1320

agccgtagtt aggccaccac ttcaagaact ctgtagcacc gcctacatac ctcgctctgc     1380

taatcctgtt accagtggct gctgccagtg gcgataagtc gtgtcttacc gggttggact     1440

caagacgata gttaccggat aaggcgcagc ggtcgggctg aacggggggt tcgtgcacac     1500

agcccagctt ggagcgaacg acctacaccg aactgagata cctacagcgt gagctatgag     1560

aaagcgccac gcttcccgaa gggagaaagg cggacaggta tccggtaagc ggcagggtcg     1620

gaacaggaga gcgcacgagg gagcttccag ggggaaacgc ctggtatctt tatagtcctg     1680

tcgggtttcg ccacctctga cttgagcgtc gatttttgtg atgctcgtca ggggggcgga     1740

gcctatggaa aaacgccagc aacgcggcct ttttacggtt cctggccttt tgctggcctt     1800

ttgctcacat gttctttcct gcgttatccc ctgattctgt ggataaccgt attaccgcct     1860

ttgagtgagc tgataccgct cgccgcagcc gaacgaccga gcgcagcgag tcagtgagcg     1920

aggaagcgga agagcgccca atacgcaaac cgcctctccc cgcgcgttgg ccgattcatt     1980

aatgcagctg gcacgacagg tttcccgact ggaaagcggg cagtgagcgc aacgcaatta     2040

atgtgagtta gctcactcat taggcacccc aggctttaca ctttatgctt ccggctcgta     2100

tgttgtgtgg aattgtgagc ggataacaat ttcacacagg aaacagctat gaccatgatt     2160

acgccaagcg cgcaattaac cctcactaaa gggaacaaaa gctggagctg caagcttaat     2220

gtagtcttat gcaatactct tgtagtcttg caacatggta acgatgagtt agcaacatgc     2280

cttacaagga gagaaaaagc accgtgcatg ccgattggtg gaagtaaggt ggtacgatcg     2340

tgccttatta ggaaggcaac agacgggtct gacatggatt ggacgaacca ctgaattgcc     2400

gcattgcaga gatattgtat ttaagtgcct agctcgatac aataaacggg tctctctggt     2460

tagaccagat ctgagcctgg gagctctctg gctaactagg gaacccactg cttaagcctc     2520

aataaagctt gccttgagtg cttcaagtag tgtgtgcccg tctgttgtgt gactctggta     2580

actagagatc cctcagaccc ttttagtcag tgtggaaaat ctctagcagt ggcgcccgaa     2640

cagggacctg aaagcgaaag ggaaaccaga gctctctcga cgcaggactc ggcttgctga     2700

agcgcgcacg gcaagaggcg aggggcggcg actggtgagt acgccaaaaa ttttgactag     2760

cggaggctag aaggagagag atgggtgcga gagcgtcagt attaagcggg ggagaattag     2820

atcgcgatgg gaaaaaattc ggttaaggcc agggggaaag aaaaaatata aattaaaaca     2880

tatagtatgg gcaagcaggg agctagaacg attcgcagtt aatcctggcc tgttagaaac     2940

atcagaaggc tgtagacaaa tactgggaca gctacaacca tcccttcaga caggatcaga     3000

agaacttaga tcattatata atacagtagc aaccctctat tgtgtgcatc aaaggataga     3060

gataaaagac accaaggaag ctttagacaa gatagaggaa gagcaaaaca aaagtaagac     3120

caccgcacag caagcggccg ctgatcttca gacctggagg aggagatatg agggacaatt     3180

ggagaagtga attatataaa tataaagtag taaaaattga accattagga gtagcaccca     3240

ccaaggcaaa gagaagagtg gtgcagagag aaaaaagagc agtgggaata ggagctttgt     3300

tccttgggtt cttgggagca gcaggaagca ctatgggcgc agcctcaatg acgctgacgg     3360

tacaggccag acaattattg tctggtatag tgcagcagca gaacaatttg ctgagggcta     3420

ttgaggcgca acagcatctg ttgcaactca cagtctgggg catcaagcag ctccaggcaa     3480

gaatcctggc tgtggaaaga tacctaaagg atcaacagct cctggggatt tggggttgct     3540

ctggaaaact catttgcacc actgctgtgc cttggaatgc tagttggagt aataaatctc     3600

tggaacagat tggaatcaca cgacctggat ggagtgggac agagaaatta acaattacac     3660

aagcttaata cactccttaa ttgaagaatc gcaaaaccag caagaaaaga atgaacaaga     3720

attattggaa ttagataaat gggcaagttt gtggaattgg tttaacataa caaattggct     3780

gtggtatata aaattattca taatgatagt aggaggcttg gtaggtttaa gaatagtttt     3840

tgctgtactt tctatagtga atagagttag gcagggatat tcaccattat cgtttcagac     3900

ccacctccca accccgaggg gacccgacag gcccgaagga atagaagaag aaggtggaga     3960

gagagacaga gacagatcca ttcgattagt gaacggatct cgacggttaa cttttaaaag     4020

aaaagggggg attggggggt acagtgcagg ggaaagaata gtagacataa tagcaacaga     4080

catacaaact aaagaattac aaaaacaaat tacaaaaatt caaaatttta tcgagctttg     4140

caaagatgga taaagtttta aacagagagg aatctttgca gctaatggac cttctaggtc     4200

ttgaaaggag tgcctcgtga ggctccggtg cccgtcagtg ggcagagcgc acatcgccca     4260

cagtccccga gaagttgggg ggaggggtcg gcaattgaac cggtgcctag agaaggtggc     4320

gcggggtaaa ctgggaaagt gatgtcgtgt actggctccg cctttttccc gagggtgggg     4380

gagaaccgta tataagtgca gtagtcgccg tgaacgttct ttttcgcaac gggtttgccg     4440

ccagaacaca ggtaagtgcc gtgtgtggtt cccgcgggcc tggcctcttt acgggttatg     4500

gcccttgcgt gccttgaatt acttccacct ggctgcagta cgtgattctt gatcccgagc     4560

ttcgggttgg aagtgggtgg gagagttcga ggccttgcgc ttaaggagcc ccttcgcctc     4620

gtgcttgagt tgaggcctgg cctgggcgct ggggccgccg cgtgcgaatc tggtggcacc     4680

ttcgcgcctg tctcgctgct ttcgataagt ctctagccat ttaaaatttt tgatgacctg     4740

ctgcgacgct ttttttctgg caagatagtc ttgtaaatgc gggccaagat ctgcacactg     4800

gtatttcggt ttttggggcc gcgggcggcg acggggcccg tgcgtcccag cgcacatgtt     4860

cggcgaggcg gggcctgcga gcgcggccac cgagaatcgg acgggggtag tctcaagctg     4920

gccggcctgc tctggtgcct ggcctcgcgc cgccgtgtat cgccccgccc tgggcggcaa     4980

ggctggcccg gtcggcacca gttgcgtgag cggaaagatg gccgcttccc ggccctgctg     5040

cagggagctc aaaatggagg acgcggcgct cgggagagcg ggcgggtgag tcacccacac     5100

aaaggaaaag ggcctttccg tcctcagccg tcgcttcatg tgactccacg gagtaccggg     5160

cgccgtccag gcacctcgat tagttctcga gcttttggag tacgtcgtct ttaggttggg     5220

gggaggggtt ttatgcgatg gagtttcccc acactgagtg ggtggagact gaagttaggc     5280

cagcttggca cttgatgtaa ttctccttgg aatttgccct ttttgagttt ggatcttggt     5340

tcattctcaa gcctcagaca gtggttcaaa gtttttttct tccatttcag gtgtcgtgag     5400

gaattcggta ccgcggccgc ccggggatcc atggccttac cagtgaccgc cttgctcctg     5460

ccgctggcct tgctgctcca cgccgccagg ccggacattc agatgactca gagcccgtct     5520

tccctgtccg cttcagtggg tgaccgtgtt accattacct gccgtgcttc tcagagcctg     5580

gtgcactccc agggtaacac ctatctgcgg tggtatcagc agaaaccggg caaggccccc     5640

aaagttctga tttataaggt ctctaatcgg tttagtggcg ttccgtcacg cttctcaggt     5700

agcgggtccg gaacagattt taccctgaca attagcagcc tgcaaccgga agacttcgca     5760

acctattact gccagcagtc tacccatgtg ccctggacat ttggccaggg tactaaggtt     5820

gagctgaaac gtgctggagg tggaggaagc ggaggtggag gcagcggcgg tgggggatct     5880

ggcggtgggg gaagtggcgg tgggggatca ggcggtgggg gaagcgaagt ccagctggtg     5940

gagagtggag gtggactggt gcagccagga ggcagcctgc gtctgtcctg tgccgcgtct     6000

ggctttacct tcagcgatta ctggatgaac tgggtccgtc aggcaccagg aaagggcctg     6060

gaatgggtgg cgcagattcg gaacaagcct tacaactacg agacttacta cgcggatagc     6120

gtgaagggtc gcttcaccat cagtcgtgac acatcaaaga acactgttta cctgcaaatg     6180

aacagcctgc gtgcagaaga taccgctgtc tattactgca caggctctta ttacggcatg     6240

gactactggg gccagggtac tctggtgacc gtttctagta ccacgacgcc agcgccgcga     6300

ccaccaacac cggcgcccac catcgcgtcg cagcccctgt ccctgcgccc agaggcgtgc     6360

cggccagcgg cggggggcgc agtgcacacg agggggctgg acttcgcctg tgatatctac     6420

atctgggcgc ccttggccgg gacttgtggg gtccttctcc tgtcactggt tatcaccctt     6480

tactgcaaac ggggcagaaa gaaactcctg tatatattca aacaaccatt tatgagacca     6540

gtacaaacta ctcaagagga agatggctgt agctgccgat ttccagaaga agaagaagga     6600

ggatgtgaac tgagagtgaa gttcagcagg agcgcagacg cccccgcgta caagcagggc     6660

cagaaccagc tctataacga gctcaatcta ggacgaagag aggagtacga tgttttggac     6720

aagagacgtg gccgggaccc tgagatgggg ggaaagccga gaaggaagaa ccctcaggaa     6780

ggcctgtaca atgaactgca gaaagataag atggcggagg cctacagtga gattgggatg     6840

aaaggcgagc gccggagggg caaggggcac gatggccttt accagggtct cagtacagcc     6900

accaaggaca cctacgacgc ccttcacatg caggccctgc cccctcgcta agtcgacaat     6960

caacctctgg attacaaaat ttgtgaaaga ttgactggta ttcttaacta tgttgctcct     7020

tttacgctat gtggatacgc tgctttaatg cctttgtatc atgctattgc ttcccgtatg     7080

gctttcattt tctcctcctt gtataaatcc tggttgctgt ctctttatga ggagttgtgg     7140

cccgttgtca ggcaacgtgg cgtggtgtgc actgtgtttg ctgacgcaac ccccactggt     7200

tggggcattg ccaccacctg tcagctcctt tccgggactt tcgctttccc cctccctatt     7260

gccacggcgg aactcatcgc cgcctgcctt gcccgctgct ggacaggggc tcggctgttg     7320

ggcactgaca attccgtggt gttgtcgggg aagctgacgt cctttccatg gctgctcgcc     7380

tgtgttgcca cctggattct gcgcgggacg tccttctgct acgtcccttc ggccctcaat     7440

ccagcggacc ttccttcccg cggcctgctg ccggctctgc ggcctcttcc gcgtcttcgc     7500

cttcgccctc agacgagtcg gatctccctt tgggccgcct ccccgcctgg aattcgagct     7560

cggtaccttt aagaccaatg acttacaagg cagctgtaga tcttagccac tttttaaaag     7620

aaaagggggg actggaaggg ctaattcact cccaacgaag acaagatctg ctttttgctt     7680

gtactgggtc tctctggtta gaccagatct gagcctggga gctctctggc taactaggga     7740

acccactgct taagcctcaa taaagcttgc cttgagtgct tcaagtagtg tgtgcccgtc     7800

tgttgtgtga ctctggtaac tagagatccc tcagaccctt ttagtcagtg tggaaaatct     7860

ctagcagtag tagttcatgt catcttatta ttcagtattt ataacttgca aagaaatgaa     7920

tatcagagag tgagaggaac ttgtttattg cagcttataa tggttacaaa taaagcaata     7980

gcatcacaaa tttcacaaat aaagcatttt tttcactgca ttctagttgt ggtttgtcca     8040

aactcatcaa tgtatcttat catgtctggc tctagctatc ccgcccctaa ctccgcccag     8100

ttccgcccat tctccgcccc atggctgact aatttttttt atttatgcag aggccgaggc     8160

cgcctcggcc tctgagctat tccagaagta gtgaggaggc ttttttggag gcctaggctt     8220

ttgcgtcgag acgtacccaa ttcgccctat agtgagtcgt attacgcgcg ctcactggcc     8280

gtcgttttac aacgtcgtga ctgggaaaac cctggcgtta cccaacttaa tcgccttgca     8340

gcacatcccc ctttcgccag ctggcgtaat agcgaagagg cccgcaccga tcgcccttcc     8400

caacagttgc gcagcctgaa tggcgaatgg cgcgacgcgc cctgtagcgg cgcattaagc     8460

gcggcgggtg tggtggttac gcgcagcgtg accgctacac ttgccagcgc cctagcgccc     8520

gctcctttcg ctttcttccc ttcctttctc gccacgttcg ccggctttcc ccgtcaagct     8580

ctaaatcggg ggctcccttt agggttccga tttagtgctt tacggcacct cgaccccaaa     8640

aaacttgatt agggtgatgg ttcacgtagt gggccatcgc cctgatagac ggtttttcgc     8700

cctttgacgt tggagtccac gttctttaat agtggactct tgttccaaac tggaacaaca     8760

ctcaacccta tctcggtcta ttcttttgat ttataaggga ttttgccgat ttcggcctat     8820

tggttaaaaa atgagctgat ttaacaaaaa tttaacgcga attttaacaa aatattaacg     8880

tttacaattt cc                                                         8892


<210>  89
<211>  8868
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic CAR construct

<400>  89
caggtggcac ttttcgggga aatgtgcgcg gaacccctat ttgtttattt ttctaaatac       60

attcaaatat gtatccgctc atgagacaat aaccctgata aatgcttcaa taatattgaa      120

aaaggaagag tatgagtatt caacatttcc gtgtcgccct tattcccttt tttgcggcat      180

tttgccttcc tgtttttgct cacccagaaa cgctggtgaa agtaaaagat gctgaagatc      240

agttgggtgc acgagtgggt tacatcgaac tggatctcaa cagcggtaag atccttgaga      300

gttttcgccc cgaagaacgt tttccaatga tgagcacttt taaagttctg ctatgtggcg      360

cggtattatc ccgtattgac gccgggcaag agcaactcgg tcgccgcata cactattctc      420

agaatgactt ggttgagtac tcaccagtca cagaaaagca tcttacggat ggcatgacag      480

taagagaatt atgcagtgct gccataacca tgagtgataa cactgcggcc aacttacttc      540

tgacaacgat cggaggaccg aaggagctaa ccgctttttt gcacaacatg ggggatcatg      600

taactcgcct tgatcgttgg gaaccggagc tgaatgaagc cataccaaac gacgagcgtg      660

acaccacgat gcctgtagca atggcaacaa cgttgcgcaa actattaact ggcgaactac      720

ttactctagc ttcccggcaa caattaatag actggatgga ggcggataaa gttgcaggac      780

cacttctgcg ctcggccctt ccggctggct ggtttattgc tgataaatct ggagccggtg      840

agcgtgggtc tcgcggtatc attgcagcac tggggccaga tggtaagccc tcccgtatcg      900

tagttatcta cacgacgggg agtcaggcaa ctatggatga acgaaataga cagatcgctg      960

agataggtgc ctcactgatt aagcattggt aactgtcaga ccaagtttac tcatatatac     1020

tttagattga tttaaaactt catttttaat ttaaaaggat ctaggtgaag atcctttttg     1080

ataatctcat gaccaaaatc ccttaacgtg agttttcgtt ccactgagcg tcagaccccg     1140

tagaaaagat caaaggatct tcttgagatc ctttttttct gcgcgtaatc tgctgcttgc     1200

aaacaaaaaa accaccgcta ccagcggtgg tttgtttgcc ggatcaagag ctaccaactc     1260

tttttccgaa ggtaactggc ttcagcagag cgcagatacc aaatactgtc cttctagtgt     1320

agccgtagtt aggccaccac ttcaagaact ctgtagcacc gcctacatac ctcgctctgc     1380

taatcctgtt accagtggct gctgccagtg gcgataagtc gtgtcttacc gggttggact     1440

caagacgata gttaccggat aaggcgcagc ggtcgggctg aacggggggt tcgtgcacac     1500

agcccagctt ggagcgaacg acctacaccg aactgagata cctacagcgt gagctatgag     1560

aaagcgccac gcttcccgaa gggagaaagg cggacaggta tccggtaagc ggcagggtcg     1620

gaacaggaga gcgcacgagg gagcttccag ggggaaacgc ctggtatctt tatagtcctg     1680

tcgggtttcg ccacctctga cttgagcgtc gatttttgtg atgctcgtca ggggggcgga     1740

gcctatggaa aaacgccagc aacgcggcct ttttacggtt cctggccttt tgctggcctt     1800

ttgctcacat gttctttcct gcgttatccc ctgattctgt ggataaccgt attaccgcct     1860

ttgagtgagc tgataccgct cgccgcagcc gaacgaccga gcgcagcgag tcagtgagcg     1920

aggaagcgga agagcgccca atacgcaaac cgcctctccc cgcgcgttgg ccgattcatt     1980

aatgcagctg gcacgacagg tttcccgact ggaaagcggg cagtgagcgc aacgcaatta     2040

atgtgagtta gctcactcat taggcacccc aggctttaca ctttatgctt ccggctcgta     2100

tgttgtgtgg aattgtgagc ggataacaat ttcacacagg aaacagctat gaccatgatt     2160

acgccaagcg cgcaattaac cctcactaaa gggaacaaaa gctggagctg caagcttaat     2220

gtagtcttat gcaatactct tgtagtcttg caacatggta acgatgagtt agcaacatgc     2280

cttacaagga gagaaaaagc accgtgcatg ccgattggtg gaagtaaggt ggtacgatcg     2340

tgccttatta ggaaggcaac agacgggtct gacatggatt ggacgaacca ctgaattgcc     2400

gcattgcaga gatattgtat ttaagtgcct agctcgatac aataaacggg tctctctggt     2460

tagaccagat ctgagcctgg gagctctctg gctaactagg gaacccactg cttaagcctc     2520

aataaagctt gccttgagtg cttcaagtag tgtgtgcccg tctgttgtgt gactctggta     2580

actagagatc cctcagaccc ttttagtcag tgtggaaaat ctctagcagt ggcgcccgaa     2640

cagggacctg aaagcgaaag ggaaaccaga gctctctcga cgcaggactc ggcttgctga     2700

agcgcgcacg gcaagaggcg aggggcggcg actggtgagt acgccaaaaa ttttgactag     2760

cggaggctag aaggagagag atgggtgcga gagcgtcagt attaagcggg ggagaattag     2820

atcgcgatgg gaaaaaattc ggttaaggcc agggggaaag aaaaaatata aattaaaaca     2880

tatagtatgg gcaagcaggg agctagaacg attcgcagtt aatcctggcc tgttagaaac     2940

atcagaaggc tgtagacaaa tactgggaca gctacaacca tcccttcaga caggatcaga     3000

agaacttaga tcattatata atacagtagc aaccctctat tgtgtgcatc aaaggataga     3060

gataaaagac accaaggaag ctttagacaa gatagaggaa gagcaaaaca aaagtaagac     3120

caccgcacag caagcggccg ctgatcttca gacctggagg aggagatatg agggacaatt     3180

ggagaagtga attatataaa tataaagtag taaaaattga accattagga gtagcaccca     3240

ccaaggcaaa gagaagagtg gtgcagagag aaaaaagagc agtgggaata ggagctttgt     3300

tccttgggtt cttgggagca gcaggaagca ctatgggcgc agcctcaatg acgctgacgg     3360

tacaggccag acaattattg tctggtatag tgcagcagca gaacaatttg ctgagggcta     3420

ttgaggcgca acagcatctg ttgcaactca cagtctgggg catcaagcag ctccaggcaa     3480

gaatcctggc tgtggaaaga tacctaaagg atcaacagct cctggggatt tggggttgct     3540

ctggaaaact catttgcacc actgctgtgc cttggaatgc tagttggagt aataaatctc     3600

tggaacagat tggaatcaca cgacctggat ggagtgggac agagaaatta acaattacac     3660

aagcttaata cactccttaa ttgaagaatc gcaaaaccag caagaaaaga atgaacaaga     3720

attattggaa ttagataaat gggcaagttt gtggaattgg tttaacataa caaattggct     3780

gtggtatata aaattattca taatgatagt aggaggcttg gtaggtttaa gaatagtttt     3840

tgctgtactt tctatagtga atagagttag gcagggatat tcaccattat cgtttcagac     3900

ccacctccca accccgaggg gacccgacag gcccgaagga atagaagaag aaggtggaga     3960

gagagacaga gacagatcca ttcgattagt gaacggatct cgacggttaa cttttaaaag     4020

aaaagggggg attggggggt acagtgcagg ggaaagaata gtagacataa tagcaacaga     4080

catacaaact aaagaattac aaaaacaaat tacaaaaatt caaaatttta tcgagctttg     4140

caaagatgga taaagtttta aacagagagg aatctttgca gctaatggac cttctaggtc     4200

ttgaaaggag tgcctcgtga ggctccggtg cccgtcagtg ggcagagcgc acatcgccca     4260

cagtccccga gaagttgggg ggaggggtcg gcaattgaac cggtgcctag agaaggtggc     4320

gcggggtaaa ctgggaaagt gatgtcgtgt actggctccg cctttttccc gagggtgggg     4380

gagaaccgta tataagtgca gtagtcgccg tgaacgttct ttttcgcaac gggtttgccg     4440

ccagaacaca ggtaagtgcc gtgtgtggtt cccgcgggcc tggcctcttt acgggttatg     4500

gcccttgcgt gccttgaatt acttccacct ggctgcagta cgtgattctt gatcccgagc     4560

ttcgggttgg aagtgggtgg gagagttcga ggccttgcgc ttaaggagcc ccttcgcctc     4620

gtgcttgagt tgaggcctgg cctgggcgct ggggccgccg cgtgcgaatc tggtggcacc     4680

ttcgcgcctg tctcgctgct ttcgataagt ctctagccat ttaaaatttt tgatgacctg     4740

ctgcgacgct ttttttctgg caagatagtc ttgtaaatgc gggccaagat ctgcacactg     4800

gtatttcggt ttttggggcc gcgggcggcg acggggcccg tgcgtcccag cgcacatgtt     4860

cggcgaggcg gggcctgcga gcgcggccac cgagaatcgg acgggggtag tctcaagctg     4920

gccggcctgc tctggtgcct ggcctcgcgc cgccgtgtat cgccccgccc tgggcggcaa     4980

ggctggcccg gtcggcacca gttgcgtgag cggaaagatg gccgcttccc ggccctgctg     5040

cagggagctc aaaatggagg acgcggcgct cgggagagcg ggcgggtgag tcacccacac     5100

aaaggaaaag ggcctttccg tcctcagccg tcgcttcatg tgactccacg gagtaccggg     5160

cgccgtccag gcacctcgat tagttctcga gcttttggag tacgtcgtct ttaggttggg     5220

gggaggggtt ttatgcgatg gagtttcccc acactgagtg ggtggagact gaagttaggc     5280

cagcttggca cttgatgtaa ttctccttgg aatttgccct ttttgagttt ggatcttggt     5340

tcattctcaa gcctcagaca gtggttcaaa gtttttttct tccatttcag gtgtcgtgag     5400

gaattcggta ccgcggccgc ccggggatcc atggccttac cagtgaccgc cttgctcctg     5460

ccgctggcct tgctgctcca cgccgccagg ccggatgttg ttatgacaca gaccccgctg     5520

agtctgcccg tctccctggg cgaccaggcc tccatttctt gccgtagttc acagtccctg     5580

gtgcactcta acggaaatac ctatctgcgc tggtacctgc agaaaccggg ccagagcccc     5640

aaagtcctga tctataaggt gtccaaccgg gtgtctggtg ttccggatcg cttttcaggg     5700

agcggcagcg gcaccgactt cacactgaag atcaatcgtg ttgaagcaga ggatctgggc     5760

gtctactttt gctctcagag tacacatgtg ccatggactt tcggcggtgg gaccaaactg     5820

gaaattaaga gctccgcaga tgacgctaaa aaggacgccg cgaaaaagga tgacgccaaa     5880

aaggatgacg cgaaaaagga tggaggcgtc aaactggacg agaccggtgg gggactggtg     5940

cagccgggcg gtgcaatgaa gctgagttgt gtgacttcag gttttacctt cgggcactat     6000

tggatgaact gggttcgtca gagtccagaa aaaggtctgg agtgggtcgc tcagtttcgg     6060

aacaagcctt acaactacga aacatactac tcagatagcg ttaaagggcg cttcactatt     6120

agccgtgatg actccaagtc tagtgtgtac ctgcagatga acaatctgcg ggttgaggac     6180

acaggcatct attactgcac aggggcgtcc tatggtatgg agtatctggg gcagggaaca     6240

agcgtcaccg tctcaaccac gacgccagcg ccgcgaccac caacaccggc gcccaccatc     6300

gcgtcgcagc ccctgtccct gcgcccagag gcgtgccggc cagcggcggg gggcgcagtg     6360

cacacgaggg ggctggactt cgcctgtgat atctacatct gggcgccctt ggccgggact     6420

tgtggggtcc ttctcctgtc actggttatc accctttact gcaaacgggg cagaaagaaa     6480

ctcctgtata tattcaaaca accatttatg agaccagtac aaactactca agaggaagat     6540

ggctgtagct gccgatttcc agaagaagaa gaaggaggat gtgaactgag agtgaagttc     6600

agcaggagcg cagacgcccc cgcgtacaag cagggccaga accagctcta taacgagctc     6660

aatctaggac gaagagagga gtacgatgtt ttggacaaga gacgtggccg ggaccctgag     6720

atggggggaa agccgagaag gaagaaccct caggaaggcc tgtacaatga actgcagaaa     6780

gataagatgg cggaggccta cagtgagatt gggatgaaag gcgagcgccg gaggggcaag     6840

gggcacgatg gcctttacca gggtctcagt acagccacca aggacaccta cgacgccctt     6900

cacatgcagg ccctgccccc tcgctaagtc gacaatcaac ctctggatta caaaatttgt     6960

gaaagattga ctggtattct taactatgtt gctcctttta cgctatgtgg atacgctgct     7020

ttaatgcctt tgtatcatgc tattgcttcc cgtatggctt tcattttctc ctccttgtat     7080

aaatcctggt tgctgtctct ttatgaggag ttgtggcccg ttgtcaggca acgtggcgtg     7140

gtgtgcactg tgtttgctga cgcaaccccc actggttggg gcattgccac cacctgtcag     7200

ctcctttccg ggactttcgc tttccccctc cctattgcca cggcggaact catcgccgcc     7260

tgccttgccc gctgctggac aggggctcgg ctgttgggca ctgacaattc cgtggtgttg     7320

tcggggaagc tgacgtcctt tccatggctg ctcgcctgtg ttgccacctg gattctgcgc     7380

gggacgtcct tctgctacgt cccttcggcc ctcaatccag cggaccttcc ttcccgcggc     7440

ctgctgccgg ctctgcggcc tcttccgcgt cttcgccttc gccctcagac gagtcggatc     7500

tccctttggg ccgcctcccc gcctggaatt cgagctcggt acctttaaga ccaatgactt     7560

acaaggcagc tgtagatctt agccactttt taaaagaaaa ggggggactg gaagggctaa     7620

ttcactccca acgaagacaa gatctgcttt ttgcttgtac tgggtctctc tggttagacc     7680

agatctgagc ctgggagctc tctggctaac tagggaaccc actgcttaag cctcaataaa     7740

gcttgccttg agtgcttcaa gtagtgtgtg cccgtctgtt gtgtgactct ggtaactaga     7800

gatccctcag acccttttag tcagtgtgga aaatctctag cagtagtagt tcatgtcatc     7860

ttattattca gtatttataa cttgcaaaga aatgaatatc agagagtgag aggaacttgt     7920

ttattgcagc ttataatggt tacaaataaa gcaatagcat cacaaatttc acaaataaag     7980

catttttttc actgcattct agttgtggtt tgtccaaact catcaatgta tcttatcatg     8040

tctggctcta gctatcccgc ccctaactcc gcccagttcc gcccattctc cgccccatgg     8100

ctgactaatt ttttttattt atgcagaggc cgaggccgcc tcggcctctg agctattcca     8160

gaagtagtga ggaggctttt ttggaggcct aggcttttgc gtcgagacgt acccaattcg     8220

ccctatagtg agtcgtatta cgcgcgctca ctggccgtcg ttttacaacg tcgtgactgg     8280

gaaaaccctg gcgttaccca acttaatcgc cttgcagcac atcccccttt cgccagctgg     8340

cgtaatagcg aagaggcccg caccgatcgc ccttcccaac agttgcgcag cctgaatggc     8400

gaatggcgcg acgcgccctg tagcggcgca ttaagcgcgg cgggtgtggt ggttacgcgc     8460

agcgtgaccg ctacacttgc cagcgcccta gcgcccgctc ctttcgcttt cttcccttcc     8520

tttctcgcca cgttcgccgg ctttccccgt caagctctaa atcgggggct ccctttaggg     8580

ttccgattta gtgctttacg gcacctcgac cccaaaaaac ttgattaggg tgatggttca     8640

cgtagtgggc catcgccctg atagacggtt tttcgccctt tgacgttgga gtccacgttc     8700

tttaatagtg gactcttgtt ccaaactgga acaacactca accctatctc ggtctattct     8760

tttgatttat aagggatttt gccgatttcg gcctattggt taaaaaatga gctgatttaa     8820

caaaaattta acgcgaattt taacaaaata ttaacgttta caatttcc                  8868


<210>  90
<211>  8859
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic CAR construct

<400>  90
caggtggcac ttttcgggga aatgtgcgcg gaacccctat ttgtttattt ttctaaatac       60

attcaaatat gtatccgctc atgagacaat aaccctgata aatgcttcaa taatattgaa      120

aaaggaagag tatgagtatt caacatttcc gtgtcgccct tattcccttt tttgcggcat      180

tttgccttcc tgtttttgct cacccagaaa cgctggtgaa agtaaaagat gctgaagatc      240

agttgggtgc acgagtgggt tacatcgaac tggatctcaa cagcggtaag atccttgaga      300

gttttcgccc cgaagaacgt tttccaatga tgagcacttt taaagttctg ctatgtggcg      360

cggtattatc ccgtattgac gccgggcaag agcaactcgg tcgccgcata cactattctc      420

agaatgactt ggttgagtac tcaccagtca cagaaaagca tcttacggat ggcatgacag      480

taagagaatt atgcagtgct gccataacca tgagtgataa cactgcggcc aacttacttc      540

tgacaacgat cggaggaccg aaggagctaa ccgctttttt gcacaacatg ggggatcatg      600

taactcgcct tgatcgttgg gaaccggagc tgaatgaagc cataccaaac gacgagcgtg      660

acaccacgat gcctgtagca atggcaacaa cgttgcgcaa actattaact ggcgaactac      720

ttactctagc ttcccggcaa caattaatag actggatgga ggcggataaa gttgcaggac      780

cacttctgcg ctcggccctt ccggctggct ggtttattgc tgataaatct ggagccggtg      840

agcgtgggtc tcgcggtatc attgcagcac tggggccaga tggtaagccc tcccgtatcg      900

tagttatcta cacgacgggg agtcaggcaa ctatggatga acgaaataga cagatcgctg      960

agataggtgc ctcactgatt aagcattggt aactgtcaga ccaagtttac tcatatatac     1020

tttagattga tttaaaactt catttttaat ttaaaaggat ctaggtgaag atcctttttg     1080

ataatctcat gaccaaaatc ccttaacgtg agttttcgtt ccactgagcg tcagaccccg     1140

tagaaaagat caaaggatct tcttgagatc ctttttttct gcgcgtaatc tgctgcttgc     1200

aaacaaaaaa accaccgcta ccagcggtgg tttgtttgcc ggatcaagag ctaccaactc     1260

tttttccgaa ggtaactggc ttcagcagag cgcagatacc aaatactgtc cttctagtgt     1320

agccgtagtt aggccaccac ttcaagaact ctgtagcacc gcctacatac ctcgctctgc     1380

taatcctgtt accagtggct gctgccagtg gcgataagtc gtgtcttacc gggttggact     1440

caagacgata gttaccggat aaggcgcagc ggtcgggctg aacggggggt tcgtgcacac     1500

agcccagctt ggagcgaacg acctacaccg aactgagata cctacagcgt gagctatgag     1560

aaagcgccac gcttcccgaa gggagaaagg cggacaggta tccggtaagc ggcagggtcg     1620

gaacaggaga gcgcacgagg gagcttccag ggggaaacgc ctggtatctt tatagtcctg     1680

tcgggtttcg ccacctctga cttgagcgtc gatttttgtg atgctcgtca ggggggcgga     1740

gcctatggaa aaacgccagc aacgcggcct ttttacggtt cctggccttt tgctggcctt     1800

ttgctcacat gttctttcct gcgttatccc ctgattctgt ggataaccgt attaccgcct     1860

ttgagtgagc tgataccgct cgccgcagcc gaacgaccga gcgcagcgag tcagtgagcg     1920

aggaagcgga agagcgccca atacgcaaac cgcctctccc cgcgcgttgg ccgattcatt     1980

aatgcagctg gcacgacagg tttcccgact ggaaagcggg cagtgagcgc aacgcaatta     2040

atgtgagtta gctcactcat taggcacccc aggctttaca ctttatgctt ccggctcgta     2100

tgttgtgtgg aattgtgagc ggataacaat ttcacacagg aaacagctat gaccatgatt     2160

acgccaagcg cgcaattaac cctcactaaa gggaacaaaa gctggagctg caagcttaat     2220

gtagtcttat gcaatactct tgtagtcttg caacatggta acgatgagtt agcaacatgc     2280

cttacaagga gagaaaaagc accgtgcatg ccgattggtg gaagtaaggt ggtacgatcg     2340

tgccttatta ggaaggcaac agacgggtct gacatggatt ggacgaacca ctgaattgcc     2400

gcattgcaga gatattgtat ttaagtgcct agctcgatac aataaacggg tctctctggt     2460

tagaccagat ctgagcctgg gagctctctg gctaactagg gaacccactg cttaagcctc     2520

aataaagctt gccttgagtg cttcaagtag tgtgtgcccg tctgttgtgt gactctggta     2580

actagagatc cctcagaccc ttttagtcag tgtggaaaat ctctagcagt ggcgcccgaa     2640

cagggacctg aaagcgaaag ggaaaccaga gctctctcga cgcaggactc ggcttgctga     2700

agcgcgcacg gcaagaggcg aggggcggcg actggtgagt acgccaaaaa ttttgactag     2760

cggaggctag aaggagagag atgggtgcga gagcgtcagt attaagcggg ggagaattag     2820

atcgcgatgg gaaaaaattc ggttaaggcc agggggaaag aaaaaatata aattaaaaca     2880

tatagtatgg gcaagcaggg agctagaacg attcgcagtt aatcctggcc tgttagaaac     2940

atcagaaggc tgtagacaaa tactgggaca gctacaacca tcccttcaga caggatcaga     3000

agaacttaga tcattatata atacagtagc aaccctctat tgtgtgcatc aaaggataga     3060

gataaaagac accaaggaag ctttagacaa gatagaggaa gagcaaaaca aaagtaagac     3120

caccgcacag caagcggccg ctgatcttca gacctggagg aggagatatg agggacaatt     3180

ggagaagtga attatataaa tataaagtag taaaaattga accattagga gtagcaccca     3240

ccaaggcaaa gagaagagtg gtgcagagag aaaaaagagc agtgggaata ggagctttgt     3300

tccttgggtt cttgggagca gcaggaagca ctatgggcgc agcctcaatg acgctgacgg     3360

tacaggccag acaattattg tctggtatag tgcagcagca gaacaatttg ctgagggcta     3420

ttgaggcgca acagcatctg ttgcaactca cagtctgggg catcaagcag ctccaggcaa     3480

gaatcctggc tgtggaaaga tacctaaagg atcaacagct cctggggatt tggggttgct     3540

ctggaaaact catttgcacc actgctgtgc cttggaatgc tagttggagt aataaatctc     3600

tggaacagat tggaatcaca cgacctggat ggagtgggac agagaaatta acaattacac     3660

aagcttaata cactccttaa ttgaagaatc gcaaaaccag caagaaaaga atgaacaaga     3720

attattggaa ttagataaat gggcaagttt gtggaattgg tttaacataa caaattggct     3780

gtggtatata aaattattca taatgatagt aggaggcttg gtaggtttaa gaatagtttt     3840

tgctgtactt tctatagtga atagagttag gcagggatat tcaccattat cgtttcagac     3900

ccacctccca accccgaggg gacccgacag gcccgaagga atagaagaag aaggtggaga     3960

gagagacaga gacagatcca ttcgattagt gaacggatct cgacggttaa cttttaaaag     4020

aaaagggggg attggggggt acagtgcagg ggaaagaata gtagacataa tagcaacaga     4080

catacaaact aaagaattac aaaaacaaat tacaaaaatt caaaatttta tcgagctttg     4140

caaagatgga taaagtttta aacagagagg aatctttgca gctaatggac cttctaggtc     4200

ttgaaaggag tgcctcgtga ggctccggtg cccgtcagtg ggcagagcgc acatcgccca     4260

cagtccccga gaagttgggg ggaggggtcg gcaattgaac cggtgcctag agaaggtggc     4320

gcggggtaaa ctgggaaagt gatgtcgtgt actggctccg cctttttccc gagggtgggg     4380

gagaaccgta tataagtgca gtagtcgccg tgaacgttct ttttcgcaac gggtttgccg     4440

ccagaacaca ggtaagtgcc gtgtgtggtt cccgcgggcc tggcctcttt acgggttatg     4500

gcccttgcgt gccttgaatt acttccacct ggctgcagta cgtgattctt gatcccgagc     4560

ttcgggttgg aagtgggtgg gagagttcga ggccttgcgc ttaaggagcc ccttcgcctc     4620

gtgcttgagt tgaggcctgg cctgggcgct ggggccgccg cgtgcgaatc tggtggcacc     4680

ttcgcgcctg tctcgctgct ttcgataagt ctctagccat ttaaaatttt tgatgacctg     4740

ctgcgacgct ttttttctgg caagatagtc ttgtaaatgc gggccaagat ctgcacactg     4800

gtatttcggt ttttggggcc gcgggcggcg acggggcccg tgcgtcccag cgcacatgtt     4860

cggcgaggcg gggcctgcga gcgcggccac cgagaatcgg acgggggtag tctcaagctg     4920

gccggcctgc tctggtgcct ggcctcgcgc cgccgtgtat cgccccgccc tgggcggcaa     4980

ggctggcccg gtcggcacca gttgcgtgag cggaaagatg gccgcttccc ggccctgctg     5040

cagggagctc aaaatggagg acgcggcgct cgggagagcg ggcgggtgag tcacccacac     5100

aaaggaaaag ggcctttccg tcctcagccg tcgcttcatg tgactccacg gagtaccggg     5160

cgccgtccag gcacctcgat tagttctcga gcttttggag tacgtcgtct ttaggttggg     5220

gggaggggtt ttatgcgatg gagtttcccc acactgagtg ggtggagact gaagttaggc     5280

cagcttggca cttgatgtaa ttctccttgg aatttgccct ttttgagttt ggatcttggt     5340

tcattctcaa gcctcagaca gtggttcaaa gtttttttct tccatttcag gtgtcgtgag     5400

gaattcggta ccgcggccgc ccggggatcc atggccttac cagtgaccgc cttgctcctg     5460

ccgctggcct tgctgctcca cgccgccagg ccgcaggttc agctggttga gagcggaggc     5520

aatctggttc agcccggtgg tagtctgcgt ctgtcttgtg cggcgtcagg gttcactttc     5580

ggtagttttt caatgagctg ggtccgtcag gcaccaggcg gtgggctgga atgggtggca     5640

ggtctgtctg cacgtagctc cctgacccac tatgcagata gtgttaaagg gcggttcaca     5700

atttcacgcg acaacgctaa gaatagcgtc tacctgcaaa tgaactccct gcgggtcgag     5760

gataccgcag tgtattactg cgctcgccgt tcttatgact ctagtggata ctggggccat     5820

ttttatagct acatggatgt gtggggacag ggcactctgg tgaccgtttc cggaggcggt     5880

gggtctggag gcggtgggag tggaggcggt gggtcaagcg ttctgaccca gccgtcctct     5940

gtcagcgccg cgccaggcca gaaagtgaca atttcctgtt ctggaagtac ttcaaacatc     6000

ggcaacaatt atgtttcctg gtatcagcag cacccgggca aagcgcccaa gctgatgatt     6060

tatgatgtgt ctaaacgtcc aagtggtgtt cctgaccggt tcagcggttc caagtctggg     6120

aatagtgcct cactggacat ctcaggcctg caaagcgaag atgaggcgga ctattactgc     6180

gcagcttggg atgacagcct gtccgaattt ctgttcggca ccgggacaaa gctgaccgtg     6240

ctgggcacca cgacgccagc gccgcgacca ccaacaccgg cgcccaccat cgcgtcgcag     6300

cccctgtccc tgcgcccaga ggcgtgccgg ccagcggcgg ggggcgcagt gcacacgagg     6360

gggctggact tcgcctgtga tatctacatc tgggcgccct tggccgggac ttgtggggtc     6420

cttctcctgt cactggttat caccctttac tgcaaacggg gcagaaagaa actcctgtat     6480

atattcaaac aaccatttat gagaccagta caaactactc aagaggaaga tggctgtagc     6540

tgccgatttc cagaagaaga agaaggagga tgtgaactga gagtgaagtt cagcaggagc     6600

gcagacgccc ccgcgtacaa gcagggccag aaccagctct ataacgagct caatctagga     6660

cgaagagagg agtacgatgt tttggacaag agacgtggcc gggaccctga gatgggggga     6720

aagccgagaa ggaagaaccc tcaggaaggc ctgtacaatg aactgcagaa agataagatg     6780

gcggaggcct acagtgagat tgggatgaaa ggcgagcgcc ggaggggcaa ggggcacgat     6840

ggcctttacc agggtctcag tacagccacc aaggacacct acgacgccct tcacatgcag     6900

gccctgcccc ctcgctaagt cgacaatcaa cctctggatt acaaaatttg tgaaagattg     6960

actggtattc ttaactatgt tgctcctttt acgctatgtg gatacgctgc tttaatgcct     7020

ttgtatcatg ctattgcttc ccgtatggct ttcattttct cctccttgta taaatcctgg     7080

ttgctgtctc tttatgagga gttgtggccc gttgtcaggc aacgtggcgt ggtgtgcact     7140

gtgtttgctg acgcaacccc cactggttgg ggcattgcca ccacctgtca gctcctttcc     7200

gggactttcg ctttccccct ccctattgcc acggcggaac tcatcgccgc ctgccttgcc     7260

cgctgctgga caggggctcg gctgttgggc actgacaatt ccgtggtgtt gtcggggaag     7320

ctgacgtcct ttccatggct gctcgcctgt gttgccacct ggattctgcg cgggacgtcc     7380

ttctgctacg tcccttcggc cctcaatcca gcggaccttc cttcccgcgg cctgctgccg     7440

gctctgcggc ctcttccgcg tcttcgcctt cgccctcaga cgagtcggat ctccctttgg     7500

gccgcctccc cgcctggaat tcgagctcgg tacctttaag accaatgact tacaaggcag     7560

ctgtagatct tagccacttt ttaaaagaaa aggggggact ggaagggcta attcactccc     7620

aacgaagaca agatctgctt tttgcttgta ctgggtctct ctggttagac cagatctgag     7680

cctgggagct ctctggctaa ctagggaacc cactgcttaa gcctcaataa agcttgcctt     7740

gagtgcttca agtagtgtgt gcccgtctgt tgtgtgactc tggtaactag agatccctca     7800

gaccctttta gtcagtgtgg aaaatctcta gcagtagtag ttcatgtcat cttattattc     7860

agtatttata acttgcaaag aaatgaatat cagagagtga gaggaacttg tttattgcag     7920

cttataatgg ttacaaataa agcaatagca tcacaaattt cacaaataaa gcattttttt     7980

cactgcattc tagttgtggt ttgtccaaac tcatcaatgt atcttatcat gtctggctct     8040

agctatcccg cccctaactc cgcccagttc cgcccattct ccgccccatg gctgactaat     8100

tttttttatt tatgcagagg ccgaggccgc ctcggcctct gagctattcc agaagtagtg     8160

aggaggcttt tttggaggcc taggcttttg cgtcgagacg tacccaattc gccctatagt     8220

gagtcgtatt acgcgcgctc actggccgtc gttttacaac gtcgtgactg ggaaaaccct     8280

ggcgttaccc aacttaatcg ccttgcagca catccccctt tcgccagctg gcgtaatagc     8340

gaagaggccc gcaccgatcg cccttcccaa cagttgcgca gcctgaatgg cgaatggcgc     8400

gacgcgccct gtagcggcgc attaagcgcg gcgggtgtgg tggttacgcg cagcgtgacc     8460

gctacacttg ccagcgccct agcgcccgct cctttcgctt tcttcccttc ctttctcgcc     8520

acgttcgccg gctttccccg tcaagctcta aatcgggggc tccctttagg gttccgattt     8580

agtgctttac ggcacctcga ccccaaaaaa cttgattagg gtgatggttc acgtagtggg     8640

ccatcgccct gatagacggt ttttcgccct ttgacgttgg agtccacgtt ctttaatagt     8700

ggactcttgt tccaaactgg aacaacactc aaccctatct cggtctattc ttttgattta     8760

taagggattt tgccgatttc ggcctattgg ttaaaaaatg agctgattta acaaaaattt     8820

aacgcgaatt ttaacaaaat attaacgttt acaatttcc                            8859


<210>  91
<211>  474
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic CAR construct

<400>  91

Gln Val Gln Leu Val Glu Ser Gly Gly Asn Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Gly Ser Phe 
            20                  25                  30          


Ser Met Ser Trp Val Arg Gln Ala Pro Gly Gly Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Gly Leu Ser Ala Arg Ser Ser Leu Thr His Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Val Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Arg Ser Tyr Asp Ser Ser Gly Tyr Trp Gly His Phe Tyr Ser 
            100                 105                 110         


Tyr Met Asp Val Trp Gly Gln Gly Thr Leu Val Thr Val Ser Gly Gly 
        115                 120                 125             


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ser Val Leu 
    130                 135                 140                 


Thr Gln Pro Ser Ser Val Ser Ala Ala Pro Gly Gln Lys Val Thr Ile 
145                 150                 155                 160 


Ser Cys Ser Gly Ser Thr Ser Asn Ile Gly Asn Asn Tyr Val Ser Trp 
                165                 170                 175     


Tyr Gln Gln His Pro Gly Lys Ala Pro Lys Leu Met Ile Tyr Asp Val 
            180                 185                 190         


Ser Lys Arg Pro Ser Gly Val Pro Asp Arg Phe Ser Gly Ser Lys Ser 
        195                 200                 205             


Gly Asn Ser Ala Ser Leu Asp Ile Ser Gly Leu Gln Ser Glu Asp Glu 
    210                 215                 220                 


Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Asp Ser Leu Ser Glu Phe Leu 
225                 230                 235                 240 


Phe Gly Thr Gly Thr Lys Leu Thr Val Leu Gly Thr Thr Thr Pro Ala 
                245                 250                 255     


Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser 
            260                 265                 270         


Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr 
        275                 280                 285             


Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala 
    290                 295                 300                 


Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys 
305                 310                 315                 320 


Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met 
                325                 330                 335     


Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe 
            340                 345                 350         


Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg Val Lys Phe Ser Arg 
        355                 360                 365             


Ser Ala Asp Ala Pro Ala Tyr Lys Gln Gly Gln Asn Gln Leu Tyr Asn 
    370                 375                 380                 


Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg 
385                 390                 395                 400 


Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro 
                405                 410                 415     


Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala 
            420                 425                 430         


Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His 
        435                 440                 445             


Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp 
    450                 455                 460                 


Ala Leu His Met Gln Ala Leu Pro Pro Arg 
465                 470                 


<210>  92
<211>  442
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic CAR construct

<400>  92

Gln Val Gln Leu Val Glu Ser Gly Gly Asn Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Gly Ser Phe 
            20                  25                  30          


Ser Met Ser Trp Val Arg Gln Ala Pro Gly Gly Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Gly Leu Ser Ala Arg Ser Ser Leu Thr His Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Val Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Arg Ser Tyr Asp Ser Ser Gly Tyr Trp Gly His Phe Tyr Ser 
            100                 105                 110         


Tyr Met Asp Val Trp Gly Gln Gly Thr Leu Val Thr Val Ser Gly Gly 
        115                 120                 125             


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ser Val Leu 
    130                 135                 140                 


Thr Gln Pro Ser Ser Val Ser Ala Ala Pro Gly Gln Lys Val Thr Ile 
145                 150                 155                 160 


Ser Cys Ser Gly Ser Thr Ser Asn Ile Gly Asn Asn Tyr Val Ser Trp 
                165                 170                 175     


Tyr Gln Gln His Pro Gly Lys Ala Pro Lys Leu Met Ile Tyr Asp Val 
            180                 185                 190         


Ser Lys Arg Pro Ser Gly Val Pro Asp Arg Phe Ser Gly Ser Lys Ser 
        195                 200                 205             


Gly Asn Ser Ala Ser Leu Asp Ile Ser Gly Leu Gln Ser Glu Asp Glu 
    210                 215                 220                 


Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Asp Ser Leu Ser Glu Phe Leu 
225                 230                 235                 240 


Phe Gly Thr Gly Thr Lys Leu Thr Val Leu Gly Glu Ser Lys Tyr Gly 
                245                 250                 255     


Pro Pro Cys Pro Pro Cys Pro Asp Ile Tyr Ile Trp Ala Pro Leu Ala 
            260                 265                 270         


Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys 
        275                 280                 285             


Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met 
    290                 295                 300                 


Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe 
305                 310                 315                 320 


Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg Val Lys Phe Ser Arg 
                325                 330                 335     


Ser Ala Asp Ala Pro Ala Tyr Lys Gln Gly Gln Asn Gln Leu Tyr Asn 
            340                 345                 350         


Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg 
        355                 360                 365             


Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro 
    370                 375                 380                 


Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala 
385                 390                 395                 400 


Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His 
                405                 410                 415     


Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp 
            420                 425                 430         


Ala Leu His Met Gln Ala Leu Pro Pro Arg 
        435                 440         


<210>  93
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic linker sequence

<400>  93

Gly Gly Gly Gly Ser 
1               5   


<210>  94
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic linker sequence

<400>  94

Gly Gly Gly Ser 
1               


<210>  95
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic linker sequence

<400>  95

Gly Gly Ser 
1           


<210>  96
<211>  2
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic linker sequence

<400>  96

Gly Ser 
1       


<210>  97
<211>  2
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic linker sequence


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  any amino acid

<400>  97

Xaa Ser 
1       


<210>  98
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic linker sequence

<400>  98

Leu Val Gly Glu Ala Ala Ala Lys Glu Ala Ala Ala Lys Ala 
1               5                   10                  


<210>  99
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic linker sequence

<400>  99

Ala Glu Ala Ala Ala Lys Glu Ala Ala Ala Lys Ala 
1               5                   10          


<210>  100
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic linker sequence

<400>  100

Glu Ala Ala Ala Lys Glu Ala Ala Ala Lys Glu Ala Ala Ala Lys Ala 
1               5                   10                  15      


<210>  101
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic linker sequence

<400>  101

Glu Gly Lys Ser Ser Gly Ser Gly Ser Glu Ser Lys Ser Thr 
1               5                   10                  


<210>  102
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic linker sequence

<400>  102

Gly Ser Ala Gly Ser Ala Ala Gly Ser Gly Glu Phe 
1               5                   10          


<210>  103
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic linker sequence

<400>  103

Ala Pro Ala Pro Ala Pro Ala Pro Ala Pro Ala Pro Ala Pro 
1               5                   10                  


<210>  104
<211>  7028
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic CAR construct

<400>  104
tcgagaagct tgccaccatg ggtgtcccta cccagctcct gggactgctc ctgctgtgga       60

tcaccgacgc catctgcgac gccgttgtga cccaggaatc cgctctgacc tcttctccag      120

gcgaaaccgt gactctgact tgccgtagta gcaccggggc tgtgaccaca tctaactatg      180

ccagttgggt ccaggaaaaa ccggatcacc tgtttactgg cctgattggc ggcaccaaca      240

atcgcgcacc gggtgtgccc gctcgtttca gcggttccct gattggggac aaggcagcac      300

tgactatcac cggcgcccag accgaagatg aggcgatcta tttttgcgtc ctgtggtaca      360

gcgaccattg ggtgttcggg ggaggcacca aactgacagt gctgggcgga ggaggaggtt      420

caggaggagg aggtagcggg ggaggcggtt ccgggggagg cggttctgat gtgcagctgc      480

aagaatccgg gccaggactg gttgcgcctt ctcagagtct gtcaattaca tgtactgtta      540

gtggctttct gctgaccgac tatggtgtga actgggttcg tcagagccca ggcaagggtc      600

tggagtggct gggagtgatt tggggggatg gaatcacaga ctacaatagc gcactgaaat      660

ctcggctgag tgttaccaaa gataacagca agtcccaggt cttcctgaag atgaacagcc      720

tgcaaagcgg cgactccgct cgctattact gcgttaccgg actgtttgat tattgggggc      780

aggggacaac tctgactgtt tcctccatcg agttcatgta cccccctccc tacctggaca      840

acgagagaag caacggcacc atcatccaca tcaaagaaaa gcacctgtgc cacacccaga      900

gcagccccaa gctgttctgg gccctggtgg tggtggccgg cgtgctgttc tgttacggcc      960

tgctggtcac agtggccctg tgcgtgatct ggaccaacag cagaagaaac agaggcggcc     1020

agagcgacta catgaacatg acccccagaa ggccaggcct gaccagaaag ccctaccagc     1080

cctacgcccc tgccagagac ttcgccgcct acagacccag agccaagttc agcagatccg     1140

ccgagacagc cgccaacctg caggatccca accagctgtt caacgagctg aacctgggca     1200

gacgggagga attcgacgtg ctggaaaaga agagagccag ggaccccgag atgggcggca     1260

agcagcagag aagaagaaac cctcaggaag gcgtctacaa cgccctgcag aaagacaaga     1320

tggccgaggc ctacagcgag atcggcacca agggcgagag aagaaggggc aagggccacg     1380

atggcctgtt ccagggcctg tccaccgcca ccaaggacac cttcgacgcc ctgcacatgc     1440

agaccctggc ccccagatga gtcgacggta ccgcgggccc gggatccgat aaaataaaag     1500

attttattta gtctccagaa aaagggggga atgaaagacc ccacctgtag gtttggcaag     1560

ctagcttaag taacgccatt ttgcaaggca tggaaaatac ataactgaga atagagaagt     1620

tcagatcaag gttaggaaca gagagacagc agaatatggg ccaaacagga tatctgtggt     1680

aagcagttcc tgccccggct cagggccaag aacagatggt ccccagatgc ggtcccgccc     1740

tcagcagttt ctagagaacc atcagatgtt tccagggtgc cccaaggacc tgaaaatgac     1800

cctgtgcctt atttgaacta accaatcagt tcgcttctcg cttctgttcg cgcgcttctg     1860

ctccccgagc tcaataaaag agcccacaac ccctcactcg gcgcgccagt cctccgatag     1920

actgcgtcgc ccgggtaccc gtgtatccaa taaaccctct tgcagttgca tccgacttgt     1980

ggtctcgctg ttccttggga gggtctcctc tgagtgattg actacccgtc agcgggggtc     2040

tttcatgggt aacagtttct tgaagttgga gaacaacatt ctgagggtag gagtcgaata     2100

ttaagtaatc ctgactcaat tagccactgt tttgaatcca catactccaa tactcctgaa     2160

atccatcgat ggagttcatt atggacagcg cagaaagagc tggggagaat tgtgaaattg     2220

ttatccgctc acaattccac acaacatacg agccggaagc ataaagtgta aagcctgggg     2280

tgcctaatga gtgagctaac tcacattaat tgcgttgcgc tcactgcccg ctttccagtc     2340

gggaaacctg tcgtgccagc tgcattaatg aatcggccaa cgcgcgggga gaggcggttt     2400

gcgtattggg cgctcttccg cttcctcgct cactgactcg ctgcgctcgg tcgttcggct     2460

gcggcgagcg gtatcagctc actcaaaggc ggtaatacgg ttatccacag aatcagggga     2520

taacgcagga aagaacatgt gagcaaaagg ccagcaaaag gccaggaacc gtaaaaaggc     2580

cgcgttgctg gcgtttttcc ataggctccg cccccctgac gagcatcaca aaaatcgacg     2640

ctcaagtcag aggtggcgaa acccgacagg actataaaga taccaggcgt ttccccctgg     2700

aagctccctc gtgcgctctc ctgttccgac cctgccgctt accggatacc tgtccgcctt     2760

tctcccttcg ggaagcgtgg cgctttctca tagctcacgc tgtaggtatc tcagttcggt     2820

gtaggtcgtt cgctccaagc tgggctgtgt gcacgaaccc cccgttcagc ccgaccgctg     2880

cgccttatcc ggtaactatc gtcttgagtc caacccggta agacacgact tatcgccact     2940

ggcagcagcc actggtaaca ggattagcag agcgaggtat gtaggcggtg ctacagagtt     3000

cttgaagtgg tggcctaact acggctacac tagaaggaca gtatttggta tctgcgctct     3060

gctgaagcca gttaccttcg gaaaaagagt tggtagctct tgatccggca aacaaaccac     3120

cgctggtagc ggtggttttt ttgtttgcaa gcagcagatt acgcgcagaa aaaaaggatc     3180

tcaagaagat cctttgatct tttctacggg gtctgacgct cagtggaacg aaaactcacg     3240

ttaagggatt ttggtcatga gattatcaaa aaggatcttc acctagatcc ttttaaatta     3300

aaaatgaagt tttaaatcaa tctaaagtat atatgagtaa acttggtctg acagttacca     3360

atgcttaatc agtgaggcac ctatctcagc gatctgtcta tttcgttcat ccatagttgc     3420

ctgactcccc gtcgtgtaga taactacgat acgggagggc ttaccatctg gccccagtgc     3480

tgcaatgata ccgcgagacc cacgctcacc ggctccagat ttatcagcaa taaaccagcc     3540

agccggaagg gccgagcgca gaagtggtcc tgcaacttta tccgcctcca tccagtctat     3600

taattgttgc cgggaagcta gagtaagtag ttcgccagtt aatagtttgc gcaacgttgt     3660

tgccattgct acaggcatcg tggtgtcacg ctcgtcgttt ggtatggctt cattcagctc     3720

cggttcccaa cgatcaaggc gagttacatg atcccccatg ttgtgcaaaa aagcggttag     3780

ctccttcggt cctccgatcg ttgtcagaag taagttggcc gcagtgttat cactcatggt     3840

tatggcagca ctgcataatt ctcttactgt catgccatcc gtaagatgct tttctgtgac     3900

tggtgagtac tcaaccaagt cattctgaga atagtgtatg cggcgaccga gttgctcttg     3960

cccggcgtca atacgggata ataccgcgcc acatagcaga actttaaaag tgctcatcat     4020

tggaaaacgt tcttcggggc gaaaactctc aaggatctta ccgctgttga gatccagttc     4080

gatgtaaccc actcgtgcac ccaactgatc ttcagcatct tttactttca ccagcgtttc     4140

tgggtgagca aaaacaggaa ggcaaaatgc cgcaaaaaag ggaataaggg cgacacggaa     4200

atgttgaata ctcatactct tcctttttca atattattga agcatttatc agggttattg     4260

tctcatgagc ggatacatat ttgaatgtat ttagaaaaat aaacaaatag gggttccgcg     4320

cacatttccc cgaaaagtgc cacctgacgt ctaagaaacc attattatca tgacattaac     4380

ctataaaaat aggcgtatca cgaggccctt tcgtctcgcg cgtttcggtg atgacggtga     4440

aaacctctga cacatgcagc tcccggagac ggtcacagct tgtctgtaag cggatgccgg     4500

gagcagacaa gcccgtcagg gcgcgtcagc gggtgttggc gggtgtcggg gctggcttaa     4560

ctatgcggca tcagagcaga ttgtactgag agtgcaccat atgcggtgtg aaataccgca     4620

cagatgcgta aggagaaaat accgcatcag gcgccattcg ccattcaggc tgcgcaactg     4680

ttgggaaggg cgatcggtgc gggcctcttc gctattacgc cagctggcga aagggggatg     4740

tgctgcaagg cgattaagtt gggtaacgcc agggttttcc cagtcacgac gttgtaaaac     4800

gacggccagt gccacgctct cccttatgcg actcctgcat taggaagcag cccagtagta     4860

ggttgaggcc gttgagcacc gccgccgcaa ggaatggtgc atgcaaggag atggcgccca     4920

acagtccccc ggccacgggg cctgccacca tacccacgcc gaaacaagcg ctcatgagcc     4980

cgaagtggcg agcccgatct tccccatcgg tgatgtcggc gatataggcg ccagcaaccg     5040

cacctgtggc gccggtgatg ccggccacga tgcgtccggc gtagaggcga tttaaagaca     5100

ggatatcagt ggtccaggct ctagttttga ctcaacaata tcaccagctg aagcctatag     5160

agtacgagcc atagataaaa taaaagattt tatttagtct ccagaaaaag gggggaatga     5220

aagaccccac ctgtaggttt ggcaagctag cttaagtaac gccattttgc aaggcatgga     5280

aaatacataa ctgagaatag agaagttcag atcaaggtta ggaacagaga gacagcagaa     5340

tatgggccaa acaggatatc tgtggtaagc agttcctgcc ccggctcagg gccaagaaca     5400

gatggtcccc agatgcggtc ccgccctcag cagtttctag agaaccatca gatgtttcca     5460

gggtgcccca aggacctgaa aatgaccctg tgccttattt gaactaacca atcagttcgc     5520

ttctcgcttc tgttcgcgcg cttctgctcc ccgagctcaa taaaagagcc cacaacccct     5580

cactcggcgc gccagtcctc cgatagactg cgtcgcccgg gtacccgtat tcccaataaa     5640

gcctcttgct gtttgcatcc gaatcgtgga ctcgctgatc cttgggaggg tctcctcaga     5700

ttgattgact gcccacctcg ggggtctttc atttggaggt tccaccgaga tttggagacc     5760

cctgcctagg gaccaccgac ccccccgccg ggaggtaagc tggccagcgg tcgtttcgtg     5820

tctgtctctg tctttgtgcg tgtttgtgcc ggcatctaat gtttgcgcct gcgtctgtac     5880

tagttagcta actagctctg tatctggcgg acccgtggtg gaactgacga gttcggaaca     5940

cccggccgca accctgggag acgtcccagg gacttcgggg gccgtttttg tggcccgacc     6000

tgagtccaaa aatcccgatc gttttggact ctttggtgca ccccccttag aggagggata     6060

tgtggttctg gtaggagacg agaacctaaa acagttcccg cctccgtctg aatttttgct     6120

ttcggtttgg gaccgaagcc gcgccgcgcg tcttgtctgc tgcagcatcg ttctgtgttg     6180

tctctgtctg actgtgtttc tgtatttgtc tgagaatatg ggcccgggct agcctgttac     6240

cactccctta agtttgacct taggtcactg gaaagatgtc gagcggatcg ctcacaacca     6300

gtcggtagat gtcaagaaga gacgttgggt taccttctgc tctgcagaat ggccaacctt     6360

taacgtcgga tggccgcgag acggcacctt taaccgagac ctcatcaccc aggttaagat     6420

caaggtcttt tcacctggcc cgcatggaca cccagaccag gtcccctaca tcgtgacctg     6480

ggaagccttg gcttttgacc cccctccctg ggtcaagccc tttgtacacc ctaagcctcc     6540

gcctcctctt cctccatccg ccccgtctct cccccttgaa cctcctcgtt cgaccccgcc     6600

tcgatcctcc ctttatccag ccctcactcc ttctctaggc gcccccatat ggccatatga     6660

gatcttatat ggggcacccc cgccccttgt aaacttccct gaccctgaca tgacaagagt     6720

tactaacagc ccctctctcc aagctcactt acaggctctc tacttagtcc agcacgaagt     6780

ctggagacct ctggcggcag cctaccaaga acaactggac cgaccggtgg tacctcaccc     6840

ttaccgagtc ggcgacacag tgtgggtccg ccgacaccag actaagaacc tagaacctcg     6900

ctggaaagga ccttacacag tcctgctgac cacccccacc gccctcaaag tagacggcat     6960

cgcagcttgg atacacgccg cccacgtgaa ggctgccgac cccgggggtg gaccatcctc     7020

tagactgc                                                              7028


<210>  105
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic GCN4 mutant

<400>  105

Ala Tyr His Leu Glu Asn Glu Val Ala Arg Leu Lys Lys Leu 
1               5                   10                  


<210>  106
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic GCN4 mutant

<400>  106

Ala Ala His Leu Glu Asn Glu Val Ala Arg Leu Lys Lys Leu 
1               5                   10                  


<210>  107
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic GCN4 mutant

<400>  107

Ala Ala Ala Leu Glu Asn Glu Val Ala Arg Leu Lys Lys Leu 
1               5                   10                  


<210>  108
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic GCN4 mutant

<400>  108

Ala Ala Ala Ala Glu Asn Glu Val Ala Arg Leu Lys Lys Leu 
1               5                   10                  


<210>  109
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic GCN4 mutant

<400>  109

Asn Tyr His Leu Glu Asn Glu Val Ala Arg Leu Lys Lys Ala 
1               5                   10                  


<210>  110
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic GCN4 mutant

<400>  110

Asn Tyr His Leu Glu Asn Glu Val Ala Arg Leu Lys Ala Ala 
1               5                   10                  


<210>  111
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic GCN4 mutant

<400>  111

Asn Tyr His Leu Glu Asn Glu Val Ala Arg Leu Ala Ala Ala 
1               5                   10                  


<210>  112
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic GCN4 mutant

<400>  112

Asn Tyr His Leu Glu Asn Glu Val Ala Arg Ala Ala Ala Ala 
1               5                   10                  


<210>  113
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic GCN4 mutant

<400>  113

Leu Leu Pro Lys Asn Tyr His Leu Glu Asn Glu Val Ala Arg Leu Lys 
1               5                   10                  15      


Lys Leu 
        


<210>  114
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic GCN4 mutant

<400>  114

Asp Leu Pro Gln Lys Tyr His Leu Glu Asn Glu Val Ala Arg Leu Lys 
1               5                   10                  15      


Lys Leu 
        


<210>  115
<211>  487
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic CAR construct

<400>  115

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Asp Ala Val Val Thr Gln Glu Ser Ala Leu Thr 
            20                  25                  30          


Ser Ser Pro Gly Glu Thr Val Thr Leu Thr Cys Arg Ser Ser Thr Gly 
        35                  40                  45              


Ala Val Thr Thr Ser Asn Tyr Ala Ser Trp Val Gln Glu Lys Pro Asp 
    50                  55                  60                  


His Leu Phe Thr Gly Leu Ile Gly Gly Thr Asn Asn Arg Ala Pro Gly 
65                  70                  75                  80  


Val Pro Ala Arg Phe Ser Gly Ser Leu Ile Gly Asp Lys Ala Ala Leu 
                85                  90                  95      


Thr Ile Thr Gly Ala Gln Thr Glu Asp Glu Ala Ile Tyr Phe Cys Val 
            100                 105                 110         


Leu Trp Tyr Ser Asp His Trp Val Phe Gly Gly Gly Thr Lys Leu Thr 
        115                 120                 125             


Val Leu Gly Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
    130                 135                 140                 


Gly Ser Gly Gly Gly Gly Ser Asp Val Gln Leu Gln Glu Ser Gly Pro 
145                 150                 155                 160 


Gly Leu Val Ala Pro Ser Gln Ser Leu Ser Ile Thr Cys Thr Val Ser 
                165                 170                 175     


Gly Phe Leu Leu Thr Asp Tyr Gly Val Asn Trp Val Arg Gln Ser Pro 
            180                 185                 190         


Gly Lys Gly Leu Glu Trp Leu Gly Val Ile Trp Gly Asp Gly Ile Thr 
        195                 200                 205             


Asp Tyr Asn Ser Ala Leu Lys Ser Arg Leu Ser Val Thr Lys Asp Asn 
    210                 215                 220                 


Ser Lys Ser Gln Val Phe Leu Lys Met Asn Ser Leu Gln Ser Gly Asp 
225                 230                 235                 240 


Ser Ala Arg Tyr Tyr Cys Val Thr Gly Leu Phe Asp Tyr Trp Gly Gln 
                245                 250                 255     


Gly Thr Thr Leu Thr Val Ser Ser Thr Thr Thr Pro Ala Pro Arg Pro 
            260                 265                 270         


Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro 
        275                 280                 285             


Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu 
    290                 295                 300                 


Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys 
305                 310                 315                 320 


Gly Val Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys Lys Arg Gly 
                325                 330                 335     


Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro Val 
            340                 345                 350         


Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu 
        355                 360                 365             


Glu Glu Gly Gly Cys Glu Leu Arg Val Lys Phe Ser Arg Ser Ala Asp 
    370                 375                 380                 


Ala Pro Ala Tyr Lys Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn 
385                 390                 395                 400 


Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg 
                405                 410                 415     


Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly 
            420                 425                 430         


Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu 
        435                 440                 445             


Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu 
    450                 455                 460                 


Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His 
465                 470                 475                 480 


Met Gln Ala Leu Pro Pro Arg 
                485         


<210>  116
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic linker sequence

<400>  116

Leu Val Gly Glu Ala Ala Ala Lys Glu Ala Ala Ala Lys Ala 
1               5                   10                  


<210>  117
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic linker sequence

<400>  117

Ala Glu Ala Ala Ala Lys Glu Ala Ala Ala Lys Ala 
1               5                   10          


<210>  118
<211>  15
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic linker sequence

<400>  118
ggcgggggcg gaagt                                                        15


<210>  119
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic linker sequence

<400>  119
ggtgggggag ggagcggtgg aggtggttct                                        30


<210>  120
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic linker sequence

<400>  120

Ala Glu Ala Ala Ala Lys Glu Ala Ala Ala Lys Ala 
1               5                   10          


<210>  121
<211>  36
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic linker sequence

<400>  121
gcggaagcag ccgccaaaga ggctgccgcg aaagcg                                 36


<210>  122
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic linker sequence

<400>  122

Gly Ser Ala Gly Ser Ala Ala Gly Ser Gly Glu Phe 
1               5                   10          


<210>  123
<211>  36
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic linker sequence

<400>  123
ggttccgccg gttccgcagc cggctccgga gagttc                                 36


<210>  124
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic linker sequence

<400>  124

Lys Glu Ser Gly Ser Val Ser Ser Glu Gln Leu Ala Gln Phe Arg Ser 
1               5                   10                  15      


Leu Asp 
        


<210>  125
<211>  54
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic linker sequence

<400>  125
aaggaatccg ggagcgtgtc ttccgaacag ctggctcagt tccgcagcct ggat             54


<210>  126
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic linker sequence

<400>  126

Glu Gly Lys Ser Ser Gly Ser Gly Ser Glu Ser Lys Ser Thr 
1               5                   10                  


<210>  127
<211>  42
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic linker sequence

<400>  127
gaggggaagt cctccggctc tgggtccgag tccaagtcca ca                          42


<210>  128
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic linker sequence

<400>  128

Ala Pro Ala Pro Ala Pro Ala Pro Ala Pro Ala Pro Ala Pro 
1               5                   10                  


<210>  129
<211>  42
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic linker sequence

<400>  129
gctcccgccc ctgccccagc tcctgccccc gcacccgcac cc                          42


<210>  130
<211>  2
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic linker sequence

<400>  130

Gly Gly 
1       


<210>  131
<211>  6
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic linker sequence

<400>  131
ggcggg                                                                   6


<210>  132
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic linker sequence

<400>  132

Gly Ser Thr Ser Gly Ser Gly Lys Pro Gly Ser Gly Glu Gly Ser Thr 
1               5                   10                  15      


Lys Gly 
        


<210>  133
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic linker sequence

<400>  133

Gly Ser Thr Ser Gly Ser Gly Lys Pro Gly Ser Gly Glu Gly Ser Thr 
1               5                   10                  15      


Lys Gly 
        


<210>  134
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic linker sequence

<400>  134

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro 
1               5                   10              


<210>  135
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic linker sequence

<400>  135

Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro 
1               5                   10          


<210>  136
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic linker sequence

<400>  136

Ala Ser Thr Lys Gly Pro 
1               5       


<210>  137
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic linker sequence

<400>  137

Thr Val Ala Ala Pro 
1               5   


<210>  138
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic GNC4 variant

<400>  138

Asn Tyr His Leu Glu Asn Glu Val Ala Arg Leu Lys Lys Leu 
1               5                   10                  


<210>  139
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic GNC4 variant

<400>  139

Leu Leu Pro Lys Asn Tyr His Leu Glu Asn Glu Val Ala Arg Leu Lys 
1               5                   10                  15      


Lys Leu 
        


<210>  140
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic GNC4 variant

<400>  140

Asp Leu Pro Lys Gln Tyr His Leu Glu Asn Glu Val Ala Arg Leu Lys 
1               5                   10                  15      


Lys Leu 
        


<210>  141
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic GNC4 variant

<400>  141

Leu Leu Pro Lys Asn Tyr His Leu Glu Asn Glu Val Ala Arg Leu Lys 
1               5                   10                  15      


<210>  142
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic GNC4 variant

<400>  142

Leu Pro Lys Asn Tyr His Leu Glu Asn Glu Val Ala Arg Leu Lys 
1               5                   10                  15  


<210>  143
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic GNC4 variant

<400>  143

Pro Lys Asn Tyr His Leu Glu Asn Glu Val Ala Arg Leu Lys 
1               5                   10                  


<210>  144
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic GNC4 variant

<400>  144

Lys Asn Tyr His Leu Glu Asn Glu Val Ala Arg Leu Lys 
1               5                   10              


<210>  145
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic GNC4 variant

<400>  145

Asn Tyr His Leu Glu Asn Glu Val Ala Arg Leu Lys 
1               5                   10          


<210>  146
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic GNC4 variant

<400>  146

Asn Tyr His Leu Glu Asn Glu Val Ala Arg Leu Lys Ala 
1               5                   10              


<210>  147
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic GNC4 variant

<400>  147

Leu Leu Pro Lys Asn Tyr His Leu Glu Asn Glu Val Ala Arg Leu Lys 
1               5                   10                  15      


Ala Leu 
        


<210>  148
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic GNC4 variant

<400>  148

Lys Asn Tyr His Leu Glu Asn Glu Val Ala Arg Leu Lys Ala Leu 
1               5                   10                  15  


<210>  149
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic GNC4 variant

<400>  149

Asn Tyr His Leu Glu Asn Glu Val Ala Arg Leu Lys Ala Leu 
1               5                   10                  


<210>  150
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic GNC4 variant

<400>  150

Asn Tyr His Leu Glu Asn Glu Val Ala Arg Leu Lys Gly Leu 
1               5                   10                  


<210>  151
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic GNC4 variant

<400>  151

Asn Tyr His Leu Glu Asn Glu Val Ala Arg Leu Lys Ala Ala 
1               5                   10                  


<210>  152
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic GNC4 variant

<400>  152

Lys Asn Tyr His Leu Glu Asn Glu Val Ala Arg Leu Lys Gly Leu 
1               5                   10                  15  


<210>  153
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic GNC4 variant

<400>  153

Lys Asn Tyr His Leu Glu Asn Glu Val Ala Arg Leu Lys Ala Ala 
1               5                   10                  15  


<210>  154
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic GNC4 variant

<400>  154

Lys Asn Tyr His Leu Glu Asn Glu Val Ala Arg Leu Lys Lys Leu 
1               5                   10                  15  


<210>  155
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic GNC4 variant

<400>  155

Lys Asn Tyr His Leu Glu Asn Glu Val Ala Arg Leu Lys Ala Leu 
1               5                   10                  15  


<210>  156
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic GNC4 variant

<400>  156

Lys Asn Tyr His Leu Glu Asn Glu Val Ala Arg Leu Lys Gly Leu 
1               5                   10                  15  


<210>  157
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic GNC4 variant

<400>  157

Lys Asn Tyr His Leu Glu Asn Glu Val Ala Arg Leu Lys Ala Ala 
1               5                   10                  15  


<210>  158
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic GNC4 variant

<400>  158

Lys Asn Tyr His Leu Glu Asn Glu Val Ala Arg Leu Lys Gly Gly 
1               5                   10                  15  


<210>  159
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic GNC4 variant

<400>  159

Asn Tyr His Leu Glu Asn Glu Val Ala Arg Leu Lys Lys Leu 
1               5                   10                  


<210>  160
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic GNC4 variant

<400>  160

Asn Tyr His Leu Glu Asn Glu Val Ala Arg Leu Lys Ala Leu 
1               5                   10                  


<210>  161
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic GNC4 variant

<400>  161

Asn Tyr His Leu Glu Asn Glu Val Ala Arg Leu Lys Gly Leu 
1               5                   10                  


<210>  162
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic GNC4 variant

<400>  162

Asn Tyr His Leu Glu Asn Glu Val Ala Arg Leu Lys Ala Ala 
1               5                   10                  


<210>  163
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic GNC4 variant

<400>  163

Asn Tyr His Leu Glu Asn Glu Val Ala Arg Leu Lys Gly Gly 
1               5                   10                  


<210>  164
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic linker sequence

<400>  164

Glu Ala Ala Ala Lys Glu Ala Ala Ala Lys Glu Ala Ala Ala Lys Ala 
1               5                   10                  15      


<210>  165
<211>  45
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic hinge sequence

<400>  165

Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala 
1               5                   10                  15      


Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly 
            20                  25                  30          


Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp 
        35                  40                  45  


<210>  166
<211>  1
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic hinge sequence

<400>  166

Asp 
1   


<210>  167
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic hinge sequence

<400>  167

Glu Ser Lys Tyr Gly Pro Pro Cys Pro Ser Cys Pro 
1               5                   10          


<210>  168
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic hinge sequence

<400>  168

Glu Ser Lys Tyr Gly Pro Pro Cys Pro Pro Cys Pro 
1               5                   10          


<210>  169
<211>  237
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in lab - humanized GCN4 scFv

<400>  169

Gln Ala Val Val Thr Gln Glu Pro Ser Leu Thr Val Ser Pro Gly Gly 
1               5                   10                  15      


Thr Val Thr Leu Thr Cys Gly Ser Ser Thr Gly Ala Val Thr Thr Ser 
            20                  25                  30          


Asn Tyr Ala Ser Trp Val Gln Gln Lys Pro Gly Gln Ala Pro Arg Gly 
        35                  40                  45              


Leu Ile Gly Gly Thr Asn Asn Arg Ala Pro Gly Val Pro Ala Arg Phe 
    50                  55                  60                  


Ser Gly Ser Leu Leu Gly Gly Lys Ala Ala Leu Thr Ile Ser Gly Ala 
65                  70                  75                  80  


Gln Pro Glu Asp Glu Ala Glu Tyr Tyr Cys Val Leu Trp Tyr Ser Asp 
                85                  90                  95      


His Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Gly Gly 
            100                 105                 110         


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Val Gln Leu 
        115                 120                 125             


Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu Thr Leu Ser Leu 
    130                 135                 140                 


Thr Cys Thr Val Ser Gly Phe Leu Leu Thr Asp Tyr Gly Val Asn Trp 
145                 150                 155                 160 


Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile Gly Val Ile Trp 
                165                 170                 175     


Gly Asp Gly Ile Thr Asp Tyr Asn Pro Ser Leu Lys Ser Arg Val Thr 
            180                 185                 190         


Ile Ser Lys Asp Thr Ser Lys Asn Gln Phe Ser Leu Lys Leu Ser Ser 
        195                 200                 205             


Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Val Thr Gly Leu Phe 
    210                 215                 220                 


Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
225                 230                 235         


<210>  170
<211>  237
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in lab - humanized GCN4 scFv

<400>  170

Gln Ala Val Val Thr Gln Glu Pro Ser Leu Thr Val Ser Pro Gly Gly 
1               5                   10                  15      


Thr Val Thr Leu Thr Cys Gly Ser Ser Thr Gly Ala Val Thr Thr Ser 
            20                  25                  30          


Asn Tyr Ala Ser Trp Val Gln Gln Lys Pro Gly Gln Ala Pro Arg Gly 
        35                  40                  45              


Leu Ile Gly Gly Thr Asn Asn Arg Ala Pro Gly Val Pro Ala Arg Phe 
    50                  55                  60                  


Ser Gly Ser Leu Leu Gly Gly Lys Ala Ala Leu Thr Ile Ser Gly Ala 
65                  70                  75                  80  


Gln Pro Glu Asp Glu Ala Glu Tyr Tyr Cys Val Leu Trp Tyr Ser Asp 
                85                  90                  95      


His Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Gly Gly 
            100                 105                 110         


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Val Gln Leu 
        115                 120                 125             


Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu Thr Leu Ser Ile 
    130                 135                 140                 


Thr Cys Thr Val Ser Gly Phe Leu Leu Thr Asp Tyr Gly Val Asn Trp 
145                 150                 155                 160 


Val Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Leu Gly Val Ile Trp 
                165                 170                 175     


Gly Asp Gly Ile Thr Asp Tyr Asn Pro Ser Leu Lys Ser Arg Leu Thr 
            180                 185                 190         


Val Ser Lys Asp Thr Ser Lys Asn Gln Val Ser Leu Lys Met Ser Ser 
        195                 200                 205             


Leu Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Val Thr Gly Leu Phe 
    210                 215                 220                 


Asp Tyr Trp Gly Gln Gly Thr Leu Leu Thr Val Ser Ser 
225                 230                 235         


<210>  171
<211>  237
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in lab - humanized GCN4 scFv

<400>  171

Gln Ala Val Val Thr Gln Glu Pro Ser Leu Thr Val Ser Pro Gly Gly 
1               5                   10                  15      


Thr Val Thr Leu Thr Cys Gly Ser Ser Thr Gly Ala Val Thr Thr Ser 
            20                  25                  30          


Asn Tyr Ala Ser Trp Val Gln Gln Lys Pro Gly Gln Ala Phe Arg Gly 
        35                  40                  45              


Leu Ile Gly Gly Thr Asn Asn Arg Ala Pro Gly Val Pro Ala Arg Phe 
    50                  55                  60                  


Ser Gly Ser Leu Leu Gly Gly Lys Ala Ala Leu Thr Ile Ser Gly Ala 
65                  70                  75                  80  


Gln Pro Glu Asp Glu Ala Glu Tyr Tyr Cys Val Leu Trp Tyr Ser Asp 
                85                  90                  95      


His Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Gly Gly 
            100                 105                 110         


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Val Gln Leu 
        115                 120                 125             


Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu Thr Leu Ser Leu 
    130                 135                 140                 


Thr Cys Thr Val Ser Gly Phe Leu Leu Thr Asp Tyr Gly Val Asn Trp 
145                 150                 155                 160 


Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile Gly Val Ile Trp 
                165                 170                 175     


Gly Asp Gly Ile Thr Asp Tyr Asn Pro Ser Leu Lys Ser Arg Val Thr 
            180                 185                 190         


Ile Ser Lys Asp Thr Ser Lys Asn Gln Phe Ser Leu Lys Leu Ser Ser 
        195                 200                 205             


Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Val Thr Gly Leu Phe 
    210                 215                 220                 


Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
225                 230                 235         


<210>  172
<211>  237
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in lab - humanized GCN4 scFv

<400>  172

Gln Ala Val Val Thr Gln Glu Pro Ser Leu Thr Val Ser Pro Gly Gly 
1               5                   10                  15      


Thr Val Thr Leu Thr Cys Gly Ser Ser Thr Gly Ala Val Thr Thr Ser 
            20                  25                  30          


Asn Tyr Ala Ser Trp Val Gln Gln Lys Pro Gly Gln Ala Phe Arg Gly 
        35                  40                  45              


Leu Ile Gly Gly Thr Asn Asn Arg Ala Pro Gly Val Pro Ala Arg Phe 
    50                  55                  60                  


Ser Gly Ser Leu Leu Gly Gly Lys Ala Ala Leu Thr Ile Ser Gly Ala 
65                  70                  75                  80  


Gln Pro Glu Asp Glu Ala Glu Tyr Tyr Cys Val Leu Trp Tyr Ser Asp 
                85                  90                  95      


His Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Gly Gly 
            100                 105                 110         


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Val Gln Leu 
        115                 120                 125             


Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu Thr Leu Ser Ile 
    130                 135                 140                 


Thr Cys Thr Val Ser Gly Phe Leu Leu Thr Asp Tyr Gly Val Asn Trp 
145                 150                 155                 160 


Val Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Leu Gly Val Ile Trp 
                165                 170                 175     


Gly Asp Gly Ile Thr Asp Tyr Asn Pro Ser Leu Lys Ser Arg Leu Thr 
            180                 185                 190         


Val Ser Lys Asp Thr Ser Lys Asn Gln Val Ser Leu Lys Met Ser Ser 
        195                 200                 205             


Leu Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Val Thr Gly Leu Phe 
    210                 215                 220                 


Asp Tyr Trp Gly Gln Gly Thr Leu Leu Thr Val Ser Ser 
225                 230                 235         


<210>  173
<211>  237
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in lab - humanized GCN4 scFv

<400>  173

Gln Ala Val Val Thr Gln Glu Pro Ser Leu Thr Val Ser Pro Gly Gly 
1               5                   10                  15      


Thr Val Thr Leu Thr Cys Gly Ser Ser Thr Gly Ala Val Thr Thr Ser 
            20                  25                  30          


Asn Tyr Ala Ser Trp Val Gln Gln Lys Pro Asp His Leu Phe Arg Gly 
        35                  40                  45              


Leu Ile Gly Gly Thr Asn Asn Arg Ala Pro Gly Val Pro Ala Arg Phe 
    50                  55                  60                  


Ser Gly Ser Leu Leu Gly Gly Lys Ala Ala Leu Thr Ile Ser Gly Ala 
65                  70                  75                  80  


Gln Pro Glu Asp Glu Ala Glu Tyr Tyr Cys Val Leu Trp Tyr Ser Asp 
                85                  90                  95      


His Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Gly Gly 
            100                 105                 110         


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Val Gln Leu 
        115                 120                 125             


Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu Thr Leu Ser Leu 
    130                 135                 140                 


Thr Cys Thr Val Ser Gly Phe Leu Leu Thr Asp Tyr Gly Val Asn Trp 
145                 150                 155                 160 


Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile Gly Val Ile Trp 
                165                 170                 175     


Gly Asp Gly Ile Thr Asp Tyr Asn Pro Ser Leu Lys Ser Arg Val Thr 
            180                 185                 190         


Ile Ser Lys Asp Thr Ser Lys Asn Gln Phe Ser Leu Lys Leu Ser Ser 
        195                 200                 205             


Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Val Thr Gly Leu Phe 
    210                 215                 220                 


Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
225                 230                 235         


<210>  174
<211>  237
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in lab - humanized GCN4 scFv

<400>  174

Gln Ala Val Val Thr Gln Glu Pro Ser Leu Thr Val Ser Pro Gly Gly 
1               5                   10                  15      


Thr Val Thr Leu Thr Cys Gly Ser Ser Thr Gly Ala Val Thr Thr Ser 
            20                  25                  30          


Asn Tyr Ala Ser Trp Val Gln Gln Lys Pro Asp His Leu Phe Arg Gly 
        35                  40                  45              


Leu Ile Gly Gly Thr Asn Asn Arg Ala Pro Gly Val Pro Ala Arg Phe 
    50                  55                  60                  


Ser Gly Ser Leu Leu Gly Gly Lys Ala Ala Leu Thr Ile Ser Gly Ala 
65                  70                  75                  80  


Gln Pro Glu Asp Glu Ala Glu Tyr Tyr Cys Val Leu Trp Tyr Ser Asp 
                85                  90                  95      


His Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Gly Gly 
            100                 105                 110         


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Val Gln Leu 
        115                 120                 125             


Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu Thr Leu Ser Ile 
    130                 135                 140                 


Thr Cys Thr Val Ser Gly Phe Leu Leu Thr Asp Tyr Gly Val Asn Trp 
145                 150                 155                 160 


Val Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Leu Gly Val Ile Trp 
                165                 170                 175     


Gly Asp Gly Ile Thr Asp Tyr Asn Pro Ser Leu Lys Ser Arg Leu Thr 
            180                 185                 190         


Val Ser Lys Asp Thr Ser Lys Asn Gln Val Ser Leu Lys Met Ser Ser 
        195                 200                 205             


Leu Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Val Thr Gly Leu Phe 
    210                 215                 220                 


Asp Tyr Trp Gly Gln Gly Thr Leu Leu Thr Val Ser Ser 
225                 230                 235         


<210>  175
<211>  1443
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Made in lab - humanized GCN4 scFv

<400>  175
atggccttac cagtgaccgc cttgctcctg ccgctggcct tgctgctcca cgccgccagg       60

ccgcaggcgg tagtcaccca ggagccaagt ctcacggtga gccccggcgg taccgtcaca      120

cttacatgcg gaagctctac cggggctgtg accacaagca actacgcatc ctgggtccag      180

cagaaacccg gtcaggctcc tcggggcctc attggtggga caaataacag agccccgggt      240

gttcccgccc gattttctgg cagtcttctg ggaggaaagg ccgctctgac aatatctggc      300

gcacagcccg aagacgaggc cgagtactat tgcgtgttgt ggtatagcga ccactgggta      360

ttcggtggag gaacaaagct gacagtgctc ggcggtggag ggagtggtgg cggtggcagc      420

ggagggggcg gatcacaagt gcaattgcag gagagtggac ctggactcgt gaaaccatct      480

gaaacactct ccctgacttg tacggtttca gggttcctgc tgacagacta tggagtaaac      540

tggatcaggc agccacccgg caagggcttg gagtggattg gcgtcatttg gggcgacgga      600

atcaccgact ataacccatc actcaaatct cgggtgacca tttccaagga taccagtaag      660

aatcagttca gcctgaaact ttcatccgtg acagctgcgg acaccgccgt gtactactgt      720

gtgacaggac tttttgacta ctggggccag gggaccctgg tgacagttag ctccaccacg      780

acgccagcgc cgcgaccacc aacaccggcg cccaccatcg cgtcgcagcc cctgtccctg      840

cgcccagagg cgtgccggcc agcggcgggg ggcgcagtgc acacgagggg gctggacttc      900

gcctgtgata tctacatctg ggcgcccttg gccgggactt gtggggtcct tctcctgtca      960

ctggttatca ccctttactg caaacggggc agaaagaaac tcctgtatat attcaaacaa     1020

ccatttatga gaccagtaca aactactcaa gaggaagatg gctgtagctg ccgatttcca     1080

gaagaagaag aaggaggatg tgaactgaga gtgaagttca gcaggagcgc agacgccccc     1140

gcgtacaagc agggccagaa ccagctctat aacgagctca atctaggacg aagagaggag     1200

tacgatgttt tggacaagag acgtggccgg gaccctgaga tggggggaaa gccgagaagg     1260

aagaaccctc aggaaggcct gtacaatgaa ctgcagaaag ataagatggc ggaggcctac     1320

agtgagattg ggatgaaagg cgagcgccgg aggggcaagg ggcacgatgg cctttaccag     1380

ggtctcagta cagccaccaa ggacacctac gacgcccttc acatgcaggc cctgccccct     1440

cgc                                                                   1443


<210>  176
<211>  1443
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Made in lab - humanized GCN4 scFv

<400>  176
atggccttac cagtgaccgc cttgctcctg ccgctggcct tgctgctcca cgccgccagg       60

ccgcaggcgg tagtcaccca ggagccaagt ctcacggtga gccccggcgg taccgtcaca      120

cttacatgcg gaagctctac cggggctgtg accacaagca actacgcatc ctgggtccag      180

cagaaacccg gtcaggcgcc ccggggcctc attggtggga caaataacag agccccgggt      240

gttcccgccc gattttctgg cagtcttctg ggaggaaagg ccgctctgac aatatctggc      300

gcacagcccg aagacgaggc cgagtactat tgcgtgttgt ggtatagcga ccactgggta      360

ttcggtggag gaacaaagct gacagtgctc ggcggtggag ggagtggtgg cggtggcagc      420

ggagggggcg gatcacaagt gcaattgcag gagagtggac ctggactcgt gaaaccatct      480

gaaacactct ccataacttg tacggtttca gggttcctgc tgacagacta tggagtaaac      540

tgggttaggc agccacccgg caagggcttg gagtggctgg gcgtcatttg gggcgacgga      600

atcaccgact ataacccatc actcaaatct cggcttaccg tctccaagga tacgagtaag      660

aatcaggtca gcctgaaaat gtcatccctc acagctgcgg acaccgccgt gtactactgt      720

gtgacaggac tttttgacta ctggggccag gggaccctgc tcacagttag ctccaccacg      780

acgccagcgc cgcgaccacc aacaccggcg cccaccatcg cgtcgcagcc cctgtccctg      840

cgcccagagg cgtgccggcc agcggcgggg ggcgcagtgc acacgagggg gctggacttc      900

gcctgtgata tctacatctg ggcgcccttg gccgggactt gtggggtcct tctcctgtca      960

ctggttatca ccctttactg caaacggggc agaaagaaac tcctgtatat attcaaacaa     1020

ccatttatga gaccagtaca aactactcaa gaggaagatg gctgtagctg ccgatttcca     1080

gaagaagaag aaggaggatg tgaactgaga gtgaagttca gcaggagcgc agacgccccc     1140

gcgtacaagc agggccagaa ccagctctat aacgagctca atctaggacg aagagaggag     1200

tacgatgttt tggacaagag acgtggccgg gaccctgaga tggggggaaa gccgagaagg     1260

aagaaccctc aggaaggcct gtacaatgaa ctgcagaaag ataagatggc ggaggcctac     1320

agtgagattg ggatgaaagg cgagcgccgg aggggcaagg ggcacgatgg cctttaccag     1380

ggtctcagta cagccaccaa ggacacctac gacgcccttc acatgcaggc cctgccccct     1440

cgc                                                                   1443


<210>  177
<211>  1443
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Made in lab - humanized GCN4 scFv

<400>  177
atggccttac cagtgaccgc cttgctcctg ccgctggcct tgctgctcca cgccgccagg       60

ccgcaggcgg tagtcaccca ggagccaagt ctcacggtga gccccggcgg taccgtcaca      120

cttacatgcg gaagctctac cggggctgtg accacaagca actacgcatc ctgggtccag      180

cagaaacccg gacaagcgtt ccggggcctc attggtggga caaataacag agccccgggt      240

gttcccgccc gattttctgg cagtcttctg ggaggaaagg ccgctctgac aatatctggc      300

gcacagcccg aagacgaggc cgagtactat tgcgtgttgt ggtatagcga ccactgggta      360

ttcggtggag gaacaaagct gacagtgctc ggcggtggag ggagtggtgg cggtggcagc      420

ggagggggcg gatcacaagt gcaattgcag gagagtggac ctggactcgt gaaaccatct      480

gaaacactct ccctcacttg tacggtttca gggttcctgc tgacagacta tggagtaaac      540

tggattaggc agccacccgg caagggcttg gagtggatcg gcgtcatttg gggcgacgga      600

atcaccgact ataacccatc actcaaatct cgggtcacca tctccaagga taccagtaag      660

aatcagttca gcctgaaact gtcatccgtc acagctgcgg acaccgccgt gtactactgt      720

gtgacaggac tttttgacta ctggggccag gggaccctgg taacagttag ctccaccacg      780

acgccagcgc cgcgaccacc aacaccggcg cccaccatcg cgtcgcagcc cctgtccctg      840

cgcccagagg cgtgccggcc agcggcgggg ggcgcagtgc acacgagggg gctggacttc      900

gcctgtgata tctacatctg ggcgcccttg gccgggactt gtggggtcct tctcctgtca      960

ctggttatca ccctttactg caaacggggc agaaagaaac tcctgtatat attcaaacaa     1020

ccatttatga gaccagtaca aactactcaa gaggaagatg gctgtagctg ccgatttcca     1080

gaagaagaag aaggaggatg tgaactgaga gtgaagttca gcaggagcgc agacgccccc     1140

gcgtacaagc agggccagaa ccagctctat aacgagctca atctaggacg aagagaggag     1200

tacgatgttt tggacaagag acgtggccgg gaccctgaga tggggggaaa gccgagaagg     1260

aagaaccctc aggaaggcct gtacaatgaa ctgcagaaag ataagatggc ggaggcctac     1320

agtgagattg ggatgaaagg cgagcgccgg aggggcaagg ggcacgatgg cctttaccag     1380

ggtctcagta cagccaccaa ggacacctac gacgcccttc acatgcaggc cctgccccct     1440

cgc                                                                   1443


<210>  178
<211>  1443
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Made in lab - humanized GCN4 scFv

<400>  178
atggccttac cagtgaccgc cttgctcctg ccgctggcct tgctgctcca cgccgccagg       60

ccgcaggcgg tagtcaccca ggagccaagt ctcacggtga gccccggcgg taccgtcaca      120

cttacatgcg gaagctctac cggggctgtg accacaagca actacgcatc ctgggtccag      180

cagaaacccg gtcaggcatt ccggggcctc attggtggga caaataacag agccccgggt      240

gttcccgccc gattttctgg cagtcttctg ggaggaaagg ccgctctgac aatatctggc      300

gcacagcccg aagacgaggc cgagtactat tgcgtgttgt ggtatagcga ccactgggta      360

ttcggtggag gaacaaagct gacagtgctc ggcggtggag ggagtggtgg cggtggcagc      420

ggagggggcg gatcacaagt gcaattgcag gagagtggac ctggactcgt gaaaccatct      480

gaaacactct ccataacttg tacggtttca gggttcctgc tgacagacta tggagtaaac      540

tgggtcaggc agccacccgg caagggcttg gagtggctcg gcgtcatttg gggcgacgga      600

atcaccgact ataacccatc actcaaatct cggttgaccg tgtccaagga taccagtaag      660

aatcaggtca gcctgaaaat gtcatccctg acagctgcgg acaccgccgt gtactactgt      720

gtgacaggac tttttgacta ctggggccag gggaccctgt tgacagttag ctccaccacg      780

acgccagcgc cgcgaccacc aacaccggcg cccaccatcg cgtcgcagcc cctgtccctg      840

cgcccagagg cgtgccggcc agcggcgggg ggcgcagtgc acacgagggg gctggacttc      900

gcctgtgata tctacatctg ggcgcccttg gccgggactt gtggggtcct tctcctgtca      960

ctggttatca ccctttactg caaacggggc agaaagaaac tcctgtatat attcaaacaa     1020

ccatttatga gaccagtaca aactactcaa gaggaagatg gctgtagctg ccgatttcca     1080

gaagaagaag aaggaggatg tgaactgaga gtgaagttca gcaggagcgc agacgccccc     1140

gcgtacaagc agggccagaa ccagctctat aacgagctca atctaggacg aagagaggag     1200

tacgatgttt tggacaagag acgtggccgg gaccctgaga tggggggaaa gccgagaagg     1260

aagaaccctc aggaaggcct gtacaatgaa ctgcagaaag ataagatggc ggaggcctac     1320

agtgagattg ggatgaaagg cgagcgccgg aggggcaagg ggcacgatgg cctttaccag     1380

ggtctcagta cagccaccaa ggacacctac gacgcccttc acatgcaggc cctgccccct     1440

cgc                                                                   1443


<210>  179
<211>  1443
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Made in lab - humanized GCN4 scFv

<400>  179
atggccttac cagtgaccgc cttgctcctg ccgctggcct tgctgctcca cgccgccagg       60

ccgcaggcgg tagtcaccca ggagccaagt ctcacggtga gccccggcgg taccgtcaca      120

cttacatgcg gaagctctac cggggctgtg accacaagca actacgcatc ctgggtccag      180

cagaaacccg atcacctgtt ccggggcctc attggtggga caaataacag agccccgggt      240

gttcccgccc gattttctgg cagtcttctg ggaggaaagg ccgctctgac aatatctggc      300

gcacagcccg aagacgaggc cgagtactat tgcgtgttgt ggtatagcga ccactgggta      360

ttcggtggag gaacaaagct gacagtgctc ggcggtggag ggagtggtgg cggtggcagc      420

ggagggggcg gatcacaagt gcaattgcag gagagtggac ctggactcgt gaaaccatct      480

gaaacactct cccttacttg tacggtttca gggttcctgc tgacagacta tggagtaaac      540

tggatcaggc agccacccgg caagggcttg gagtggatcg gcgtcatttg gggcgacgga      600

atcaccgact ataacccatc actcaaatct cgggtcacca tctccaagga tacgagtaag      660

aatcagttca gcctgaaact ctcatccgtt acagctgcgg acaccgccgt gtactactgt      720

gtgacaggac tttttgacta ctggggccag gggaccctgg taacagttag ctccaccacg      780

acgccagcgc cgcgaccacc aacaccggcg cccaccatcg cgtcgcagcc cctgtccctg      840

cgcccagagg cgtgccggcc agcggcgggg ggcgcagtgc acacgagggg gctggacttc      900

gcctgtgata tctacatctg ggcgcccttg gccgggactt gtggggtcct tctcctgtca      960

ctggttatca ccctttactg caaacggggc agaaagaaac tcctgtatat attcaaacaa     1020

ccatttatga gaccagtaca aactactcaa gaggaagatg gctgtagctg ccgatttcca     1080

gaagaagaag aaggaggatg tgaactgaga gtgaagttca gcaggagcgc agacgccccc     1140

gcgtacaagc agggccagaa ccagctctat aacgagctca atctaggacg aagagaggag     1200

tacgatgttt tggacaagag acgtggccgg gaccctgaga tggggggaaa gccgagaagg     1260

aagaaccctc aggaaggcct gtacaatgaa ctgcagaaag ataagatggc ggaggcctac     1320

agtgagattg ggatgaaagg cgagcgccgg aggggcaagg ggcacgatgg cctttaccag     1380

ggtctcagta cagccaccaa ggacacctac gacgcccttc acatgcaggc cctgccccct     1440

cgc                                                                   1443


<210>  180
<211>  1443
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Made in lab - humanized GCN4 scFv

<400>  180
atggccttac cagtgaccgc cttgctcctg ccgctggcct tgctgctcca cgccgccagg       60

ccgcaggcgg tagtcaccca ggagccaagt ctcacggtga gccccggcgg taccgtcaca      120

cttacatgcg gaagctctac cggggctgtg accacaagca actacgcatc ctgggtccag      180

cagaaacccg accatctgtt tcggggcctc attggtggga caaataacag agccccgggt      240

gttcccgccc gattttctgg cagtcttctg ggaggaaagg ccgctctgac aatatctggc      300

gcacagcccg aagacgaggc cgagtactat tgcgtgttgt ggtatagcga ccactgggta      360

ttcggtggag gaacaaagct gacagtgctc ggcggtggag ggagtggtgg cggtggcagc      420

ggagggggcg gatcacaagt gcaattgcag gagagtggac ctggactcgt gaaaccatct      480

gaaacactct ccattacttg tacggtttca gggttcctgc tgacagacta tggagtaaac      540

tgggtgaggc agccacccgg caagggcttg gagtggctcg gcgtcatttg gggcgacgga      600

atcaccgact ataacccatc actcaaatct cggttgaccg tgtccaagga taccagtaag      660

aatcaggtga gcctgaaaat gtcatccctg acagctgcgg acaccgccgt gtactactgt      720

gtgacaggac tttttgacta ctggggccag gggaccctgc tgacagttag ctccaccacg      780

acgccagcgc cgcgaccacc aacaccggcg cccaccatcg cgtcgcagcc cctgtccctg      840

cgcccagagg cgtgccggcc agcggcgggg ggcgcagtgc acacgagggg gctggacttc      900

gcctgtgata tctacatctg ggcgcccttg gccgggactt gtggggtcct tctcctgtca      960

ctggttatca ccctttactg caaacggggc agaaagaaac tcctgtatat attcaaacaa     1020

ccatttatga gaccagtaca aactactcaa gaggaagatg gctgtagctg ccgatttcca     1080

gaagaagaag aaggaggatg tgaactgaga gtgaagttca gcaggagcgc agacgccccc     1140

gcgtacaagc agggccagaa ccagctctat aacgagctca atctaggacg aagagaggag     1200

tacgatgttt tggacaagag acgtggccgg gaccctgaga tggggggaaa gccgagaagg     1260

aagaaccctc aggaaggcct gtacaatgaa ctgcagaaag ataagatggc ggaggcctac     1320

agtgagattg ggatgaaagg cgagcgccgg aggggcaagg ggcacgatgg cctttaccag     1380

ggtctcagta cagccaccaa ggacacctac gacgcccttc acatgcaggc cctgccccct     1440

cgc                                                                   1443


<210>  181
<211>  1329
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic CAR construct

<400>  181
atggccttac cagtgaccgc cttgctcctg ccgctggcct tgctgctcca cgccgccagg       60

ccggacgccg ttgtgaccca ggaatccgct ctgacctctt ctccaggcga aaccgtgact      120

ctgacttgcc gtagtagcac cggggctgtg accacatcta actatgccag ttgggtccag      180

gaaaaaccgg atcacctgtt tactggcctg attggcggca ccaacaatcg cgcaccgggt      240

gtgcccgctc gtttcagcgg ttccctgatt ggggacaagg cagcactgac tatcaccggc      300

gcccagaccg aagatgaggc gatctatttt tgcgtcctgt ggtacagcga ccattgggtg      360

ttcgggggag gcaccaaact gacagtgctg ggcggaggag gaggttcagg aggaggaggt      420

agcgggggag gcggttccgg gggaggcggt tctgatgtgc agctgcaaga atccgggcca      480

ggactggttg cgccttctca gagtctgtca attacatgta ctgttagtgg ctttctgctg      540

accgactatg gtgtgaactg ggttcgtcag agcccaggca agggtctgga gtggctggga      600

gtgatttggg gggatggaat cacagactac aatagcgcac tgaaatctcg gctgagtgtt      660

accaaagata acagcaagtc ccaggtcttc ctgaagatga acagcctgca aagcggcgac      720

tccgctcgct attactgcgt taccggactg tttgattatt gggggcaggg gacaactctg      780

actgtttcct ccgatatcta catctgggcg cccttggccg ggacttgtgg ggtccttctc      840

ctgtcactgg ttatcaccct ttactgcaaa cggggcagaa agaaactcct gtatatattc      900

aaacaaccat ttatgagacc agtacaaact actcaagagg aagatggctg tagctgccga      960

tttccagaag aagaagaagg aggatgtgaa ctgagagtga agttcagcag gagcgcagac     1020

gcccccgcgt acaagcaggg ccagaaccag ctctataacg agctcaatct aggacgaaga     1080

gaggagtacg atgttttgga caagagacgt ggccgggacc ctgagatggg gggaaagccg     1140

agaaggaaga accctcagga aggcctgtac aatgaactgc agaaagataa gatggcggag     1200

gcctacagtg agattgggat gaaaggcgag cgccggaggg gcaaggggca cgatggcctt     1260

taccagggtc tcagtacagc caccaaggac acctacgacg cccttcacat gcaggccctg     1320

ccccctcgc                                                             1329


<210>  182
<211>  1365
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic CAR construct

<400>  182
atggccttac cagtgaccgc cttgctcctg ccgctggcct tgctgctcca cgccgccagg       60

ccggacgccg ttgtgaccca ggaatccgct ctgacctctt ctccaggcga aaccgtgact      120

ctgacttgcc gtagtagcac cggggctgtg accacatcta actatgccag ttgggtccag      180

gaaaaaccgg atcacctgtt tactggcctg attggcggca ccaacaatcg cgcaccgggt      240

gtgcccgctc gtttcagcgg ttccctgatt ggggacaagg cagcactgac tatcaccggc      300

gcccagaccg aagatgaggc gatctatttt tgcgtcctgt ggtacagcga ccattgggtg      360

ttcgggggag gcaccaaact gacagtgctg ggcggaggag gaggttcagg aggaggaggt      420

agcgggggag gcggttccgg gggaggcggt tctgatgtgc agctgcaaga atccgggcca      480

ggactggttg cgccttctca gagtctgtca attacatgta ctgttagtgg ctttctgctg      540

accgactatg gtgtgaactg ggttcgtcag agcccaggca agggtctgga gtggctggga      600

gtgatttggg gggatggaat cacagactac aatagcgcac tgaaatctcg gctgagtgtt      660

accaaagata acagcaagtc ccaggtcttc ctgaagatga acagcctgca aagcggcgac      720

tccgctcgct attactgcgt taccggactg tttgattatt gggggcaggg gacaactctg      780

actgtttcct ccgaaagcaa gtatggccca ccttgtccaa gctgtcccga tatctacatc      840

tgggcgccct tggccgggac ttgtggggtc cttctcctgt cactggttat caccctttac      900

tgcaaacggg gcagaaagaa actcctgtat atattcaaac aaccatttat gagaccagta      960

caaactactc aagaggaaga tggctgtagc tgccgatttc cagaagaaga agaaggagga     1020

tgtgaactga gagtgaagtt cagcaggagc gcagacgccc ccgcgtacaa gcagggccag     1080

aaccagctct ataacgagct caatctagga cgaagagagg agtacgatgt tttggacaag     1140

agacgtggcc gggaccctga gatgggggga aagccgagaa ggaagaaccc tcaggaaggc     1200

ctgtacaatg aactgcagaa agataagatg gcggaggcct acagtgagat tgggatgaaa     1260

ggcgagcgcc ggaggggcaa ggggcacgat ggcctttacc agggtctcag tacagccacc     1320

aaggacacct acgacgccct tcacatgcag gccctgcccc ctcgc                     1365


<210>  183
<211>  1365
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic CAR construct

<400>  183
atggccttac cagtgaccgc cttgctcctg ccgctggcct tgctgctcca cgccgccagg       60

ccggacgccg ttgtgaccca ggaatccgct ctgacctctt ctccaggcga aaccgtgact      120

ctgacttgcc gtagtagcac cggggctgtg accacatcta actatgccag ttgggtccag      180

gaaaaaccgg atcacctgtt tactggcctg attggcggca ccaacaatcg cgcaccgggt      240

gtgcccgctc gtttcagcgg ttccctgatt ggggacaagg cagcactgac tatcaccggc      300

gcccagaccg aagatgaggc gatctatttt tgcgtcctgt ggtacagcga ccattgggtg      360

ttcgggggag gcaccaaact gacagtgctg ggcggaggag gaggttcagg aggaggaggt      420

agcgggggag gcggttccgg gggaggcggt tctgatgtgc agctgcaaga atccgggcca      480

ggactggttg cgccttctca gagtctgtca attacatgta ctgttagtgg ctttctgctg      540

accgactatg gtgtgaactg ggttcgtcag agcccaggca agggtctgga gtggctggga      600

gtgatttggg gggatggaat cacagactac aatagcgcac tgaaatctcg gctgagtgtt      660

accaaagata acagcaagtc ccaggtcttc ctgaagatga acagcctgca aagcggcgac      720

tccgctcgct attactgcgt taccggactg tttgattatt gggggcaggg gacaactctg      780

actgtttcct ccgaaagcaa gtatggccca ccttgtccac cttgtcccga tatctacatc      840

tgggcgccct tggccgggac ttgtggggtc cttctcctgt cactggttat caccctttac      900

tgcaaacggg gcagaaagaa actcctgtat atattcaaac aaccatttat gagaccagta      960

caaactactc aagaggaaga tggctgtagc tgccgatttc cagaagaaga agaaggagga     1020

tgtgaactga gagtgaagtt cagcaggagc gcagacgccc ccgcgtacaa gcagggccag     1080

aaccagctct ataacgagct caatctagga cgaagagagg agtacgatgt tttggacaag     1140

agacgtggcc gggaccctga gatgggggga aagccgagaa ggaagaaccc tcaggaaggc     1200

ctgtacaatg aactgcagaa agataagatg gcggaggcct acagtgagat tgggatgaaa     1260

ggcgagcgcc ggaggggcaa ggggcacgat ggcctttacc agggtctcag tacagccacc     1320

aaggacacct acgacgccct tcacatgcag gccctgcccc ctcgc                     1365


<210>  184
<211>  642
<212>  DNA
<213>  Artificial Sequene

<220>
<223>  Made in Lab - antibody fragment

<400>  184
gacatccaga tgacacagac tacatcctcc ctgtctgcct ctctgggaga cagagtcacc       60

atcagttgca gggcaagtca ggacattagt aaatatttaa attggtatca gcagaaacca      120

gatggaactg ttaaactcct gatctaccat acatcaagat tacactcagg agtcccatca      180

aggttcagtg gcagtgggtc tggaacagat tattctctca ccattagcaa cctggagcaa      240

gaagatattg ccacttactt ttgccaacag ggtaatacgc ttccgtacac gttcggaggg      300

gggaccaagc ttgagatcaa acgaactgtg gctgcaccat ctgtcttcat cttcccgcca      360

tctgatgagc agttgaaatc tggaactgcc tctgtcgtgt gcctgctgaa taacttctat      420

cccagagagg ccaaagtaca gtggaaggtg gataacgccc tccaatcggg taactcccag      480

gagagtgtca cagagcagga cagcaaggac agcacctaca gcctcagcag caccctgacg      540

ctgagcaaag cagactacga gaaacacaaa gtctacgcct gcgaagtcac ccatcagggc      600

ctgtcctcgc ccgtcacaaa gagcttcaac aggggagagt gt                         642


<210>  185
<211>  669
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Made in Lab - antibody fragment

<400>  185
gaggtgaaac tgcaggagtc aggacctggc ctggtggcgc cctcacagag cctgtccgtc       60

acatgcactg tctcaggggt ctcattaccc gactatggtg taagctggat tcgccagcct      120

ccacgaaagg gtctggagtg gctgggagta atatggggta gtgaaaccac atactataat      180

tcagctctca aatccagact gaccatcatc aaggacaact ccaagagcca agttttctta      240

aaaatgaaca gtctgcaaac tgatgacaca gccatttact actgtgccaa acattattac      300

tacggtggta gctatgctat ggactactgg ggccaaggaa cctcagtcac cgtctcctca      360

gcctccacca agggcccatc ggtcttcccc ctggcaccct cctccaagag cacctctggg      420

ggcacagcgg ccctgggctg cctggtcaag gactacttcc ccgaaccggt gacggtgtcg      480

tggaactcag gcgccctgac cagcggcgtg cacaccttcc cggctgtcct acagtcctca      540

ggactctact ccctcagcag cgtggtgact gtgccctcta gcagcttggg cacccagacc      600

tacatctgca acgtgaatca caagcccagc aacaccaagg tggacaagaa agttgagccc      660

aaatcttgt                                                              669


<210>  186
<211>  1347
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Made in Lab - antibody fragment

<400>  186
gaggtgaaac tgcaggagtc aggacctggc ctggtggcgc cctcacagag cctgtccgtc       60

acatgcactg tctcaggggt ctcattaccc gactatggtg taagctggat tcgccagcct      120

ccacgaaagg gtctggagtg gctgggagta atatggggta gtgaaaccac atactataat      180

tcagctctca aatccagact gaccatcatc aaggacaact ccaagagcca agttttctta      240

aaaatgaaca gtctgcaaac tgatgacaca gccatttact actgtgccaa acattattac      300

tacggtggta gctatgctat ggactactgg ggccaaggaa cctcagtcac cgtctcctca      360

gcctccacca agggcccatc ggtcttcccc ctggcaccct cctccaagag cacctctggg      420

ggcacagcgg ccctgggctg cctggtcaag gactacttcc ccgaaccggt gacggtgtcg      480

tggaactcag gcgccctgac cagcggcgtg cacaccttcc cggctgtcct acagtcctca      540

ggactctact ccctcagcag cgtggtgact gtgccctcta gcagcttggg cacccagacc      600

tacatctgca acgtgaatca caagcccagc aacaccaagg tggacaagaa agttgagccc      660

aaatcttgtg acaaaactca cacatgccca ccgtgcccag cacctccagt cgccggaccg      720

tcagtcttcc tcttccctcc aaaacccaag gacaccctca tgatctcccg gacccctgag      780

gtcacatgcg tggtggtgga cgtgagccac gaagaccctg aggtcaagtt caactggtac      840

gtggacggcg tggaggtgca taatgccaag acaaagccgc gggaggagca gtacaacagc      900

acgtaccgtg tggtcagcgt cctcaccgtc ctgcaccagg actggctgaa tggcaaggag      960

tacaagtgca aggtctccaa caaaggcctc ccaagctcca tcgagaaaac catctccaaa     1020

gccaaagggc agccccgaga accacaggtg tacaccctgc ctccatcccg ggatgagctg     1080

accaagaacc aggtcagcct gacctgcctg gtcaaaggct tctatcccag cgacatcgcc     1140

gtggagtggg agagcaatgg gcagccggag aacaactaca agaccacgcc tcccgtgctg     1200

gactccgacg gctccttctt cctctacagc aagctcaccg tggacaagag caggtggcag     1260

caggggaacg tcttctcatg ctccgtgatg catgaggctc tgcacaacca ctacacgcag     1320

aagagcctct ccctgtctcc gggtaaa                                         1347


<210>  187
<211>  711
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Made in Lab - antibody fragment

<400>  187
atgaaaaaga atatcgcatt tcttcttgct agcatgttcg ttttttctat tgctacaaac       60

gcatacgctg acatccagat gacccagtct ccatcctccc tgtctgcatc tgtaggagac      120

agagtcacca tcacttgccg ggcaagtcag gatgtgaata ccgcggtcgc atggtatcag      180

cagaaaccag ggaaagcccc taagctcctg atctattctg catccttctt gtatagtggg      240

gtcccatcaa ggttcagtgg cagtagatct gggacagatt tcactctcac catcagcagt      300

ctgcaacctg aagattttgc aacttactac tgtcaacagc attacactac ccctccgacg      360

ttcggccaag gtaccaagct tgagatcaaa cgaactgtgg ctgcaccatc tgtcttcatc      420

ttcccgccat ctgatgagca gttgaaatct ggaactgcct ctgtcgtgtg cctgctgaat      480

aacttctatc ccagagaggc caaagtacag tggaaggtgg ataacgccct ccaatcgggt      540

aactcccagg agagtgtcac agagcaggac agcaaggaca gcacctacag cctcagcagc      600

accctgacgc tgagcaaagc agactacgag aaacacaaag tctacgcctg cgaagtcacc      660

catcagggcc tgtcctcgcc cgtcacaaag agcttcaaca ggggagagtg t               711


<210>  188
<211>  753
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Made in Lab - antibody fragment

<400>  188
atgaaaaaga atatcgcatt tcttcttgca tctatgttcg ttttttctat tgctacaaac       60

gcgtacgctg aggtgcagct ggtggagtct ggaggaggct tggtccagcc tggggggtcc      120

ctgagactct cctgtgcagc ctctgggttc aatattaagg acacttacat ccactgggtc      180

cgccaggctc cagggaaggg gctggagtgg gtcgcacgta tttatcctac caatggttac      240

acacgctacg cagactccgt gaagggccga ttcaccatct ccgcagacac ttccaagaac      300

acggcgtatc ttcaaatgaa cagcctgaga gccgaggaca cggccgtgta ttactgttcg      360

agatggggcg gtgacggctt ctatgccatg gactactggg gccaaggaac cctggtcacc      420

gtctcctcag cctccaccaa gggcccatcg gtcttccccc tggcaccctc ctccaagagc      480

acctctgggg gcacagcggc cctgggctgc ctggtcaagg actacttccc cgaaccggtg      540

acggtgtcgt ggaactcagg cgccctgacc agcggcgtgc acaccttccc ggctgtccta      600

cagtcctcag gactctactc cctcagcagc gtggtgactg tgccctctag cagcttgggc      660

acccagacct acatctgcaa cgtgaatcac aagcccagca acaccaaggt ggacaagaaa      720

gttgagccca aatcttgtga caaaactcac aca                                   753


<210>  189
<211>  708
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Made in Lab - antibody fragment

<400>  189
atgaaaaaga atatcgcatt tcttcttgct agcatgttcg ttttttctat tgctacaaac       60

gcatacgctc agattgtgct gagccagagc ccggcgattc tgagcgcgag cccgggcgaa      120

aaagtgacca tgacctgccg cgcgagcagc agcgtgagct atattcattg gtttcagcag      180

aaaccgggca gcagcccgaa accgtggatt tatgcgacca gcaacctggc gagcggcgtg      240

ccggtgcgct ttagcggcag cggcagcggc accagctata gcctgaccat tagccgcgtg      300

gaagcggaag atgcggcgac ctattattgc cagcagtgga ccagcaaccc gccgaccttt      360

ggcggcggca ccaagcttga gatcaaacga actgtggctg caccatctgt cttcatcttc      420

ccgccatctg atgagcagtt gaaatctgga actgcctctg tcgtgtgcct gctgaataac      480

ttctatccca gagaggccaa agtacagtgg aaggtggata acgccctcca atcgggtaac      540

tcccaggaga gtgtcacaga gcaggacagc aaggacagca cctacagcct cagcagcacc      600

ctgacgctga gcaaagcaga ctacgagaaa cacaaagtct acgcctgcga agtcacccat      660

cagggcctgt cctcgcccgt cacaaagagc ttcaacaggg gagagtgt                   708


<210>  190
<211>  756
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Made in Lab - antibody fragment

<400>  190
atgaaaaaga atatcgcatt tcttcttgca tctatgttcg ttttttctat tgctacaaac       60

gcgtacgctc aggtgcagct gcagcagccg ggcgcggaac tggtgaaacc gggcgcgagc      120

gtgaaaatga gctgcaaagc gagcggctat acctttacca gctataacat gcattgggtg      180

aaacagaccc cgggccgcgg cctggaatgg attggcgcga tttatccggg caacggcgat      240

accagctata accagaaatt taaaggcaaa gcgaccctga ccgcggataa aagcagcagc      300

accgcgtata tgcagctgag cagcctgacc agcgaagata gcgcggtgta ttattgcgcg      360

cgcagcacct attatggcgg cgattggtat tttaacgtgt ggggcgcggg caccaccgtg      420

accgtgagcg cggcgagcac caagggccca tcggtcttcc ccctggcacc ctcctccaag      480

agcacctctg ggggcacagc ggccctgggc tgcctggtca aggactactt ccccgaaccg      540

gtgacggtgt cgtggaactc aggcgccctg accagcggcg tgcacacctt cccggctgtc      600

ctacagtcct caggactcta ctccctcagc agcgtggtga ctgtgccctc tagcagcttg      660

ggcacccaga cctacatctg caacgtgaat cacaagccca gcaacaccaa ggtggacaag      720

aaagttgagc ccaaatcttg tgacaaaact cacaca                                756


<210>  191
<211>  708
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Made in Lab - antibody fragment

<400>  191
atgagggtcc ccgctcagct cctggggctc ctgctgctct ggctcccagg tgcacgatgt       60

gacatcctgc tgacccagtc ccccgtgatc ctgtccgtgt cccctggcga gcgggtgtcc      120

ttctcctgcc gggcctccca gtccatcggc accaacatcc actggtatca gcagcggacc      180

aacggctccc ctcggctgct gatcaagtac gcctccgagt ctatctccgg catcccttcc      240

cggttctccg gctccggctc tggcaccgac ttcaccctgt ccatcaactc cgtggagtcc      300

gaggatatcg ccgactacta ctgccagcag aacaacaact ggcctaccac cttcggcgct      360

ggaaccaagc tggagctgaa gcgtacggtg gctgcaccat ctgtcttcat cttcccgcca      420

tctgatgagc agttgaaatc tggaactgcc tctgttgtgt gcctgctgaa taacttctat      480

cccagagagg ccaaagtaca gtggaaggtg gataacgccc tccaatcggg taactcccag      540

gagagtgtca cagagcagga cagcaaggac agcacctaca gcctcagcag caccctgacg      600

ctgagcaaag cagactacga gaaacacaaa gtctacgcct gcgaagtcac ccatcagggc      660

ctgagctcgc ccgtcacaaa gagcttcaac aggggagagt gttgatga                   708


<210>  192
<211>  753
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Made in Lab - antibody fragment

<400>  192
atgggttgga gcctcatctt gctcttcctt gtcgctgttg ctacgcgtgt ccactcccag       60

gtgcagctga agcagtccgg ccctggcctg gtgcagcctt cccagtccct gtccatcacc      120

tgcaccgtgt ccggcttctc cctgaccaac tacggcgtgc actgggtgcg ccagtccccc      180

ggcaagggcc tggagtggct gggcgtgatc tggtccggcg gcaacaccga ctacaacacc      240

cctttcacct cccggctgtc catcaacaag gacaactcca agtcccaggt gttcttcaag      300

atgaactccc tgcagtccaa cgacaccgcc atctactact gcgccagagc cctgacctac      360

tatgactacg agttcgccta ctggggccag ggcaccctgg tgaccgtgtc cgccgctagc      420

accaagggcc catcggtctt ccccctggca ccctcctcca agagcacctc tgggggcaca      480

gcggccctgg gctgcctggt caaggactac ttccccgaac cggtgacggt gtcgtggaac      540

tcaggcgccc tgaccagcgg cgtgcacacc ttcccggctg tcctacagtc ctcaggactc      600

tactccctca gcagcgtggt gaccgtgccc tccagcagct tgggcaccca gacctacatc      660

tgcaacgtga atcacaagcc cagcaacacc aaggtggaca agaaagttga gcccaaatct      720

tgtgacaaaa ctcacacatg cccaccgtgc cca                                   753


<210>  193
<211>  678
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Made in Lab - antibody fragment

<400>  193
gatatccagc tgcaggagtc cggaccaggt ctggtgaagc ccagccagtc cctgtctctg       60

acctgcagcg tcactggcta ttccatcacc agtgcatact attggaactg gatcagacag      120

ttccctggaa acaaactgga gtggatgggg tacatctctt acgacggtag aaacaactac      180

aaccccagcc tcaaaaacag gattagcatt acccgcgaca ctagtaagaa ccagtttttc      240

ctgaagctca acagtgtgac aactgaggac actgctactt attattgtgc caaggagggc      300

gactatgatg tcggcaatta ttacgctatg gactattggg gtcaggggac tagcgtgacc      360

gtcagttctg ccaggaccaa aggaccgtcc gtctttcctc tggccccttc ctctaagtcc      420

acaagcggtg ggaccgcagc actgggatgc ctggtgaagg attacttccc tgagccggtg      480

accgtgtcct ggaactccgg agctctcacc tccggtgtcc atacctttcc tgccgtcctg      540

cagtcctccg gcctgtacag cctctctagc gtcgtgactg tgccctccag ctccctgggc      600

acccaaactt atatctgcaa tgttaaccac aagccttcta ataccaaggt cgacaagaaa      660

gtggagccga agagctgt                                                    678


<210>  194
<211>  645
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Made in Lab - antibody fragment

<400>  194
gaaaacgtgc tcacccagag tcccgccatc atgagcgcca gtcccggcga gaaggtgacc       60

atgacctgta gggcctcttc caatgtgatc tctagctacg tgcattggta ccagcagcgt      120

agtggggcca gccctaagct ctggatttac tccacctcca acctggcctc cggggtcccc      180

gcccgtttct ctggcagtgg ctctggtacc tcttactccc tgactatcag cagcgtcgag      240

gccgaggatg ccgctacata ctactgtcag cagtacagtg gataccctct gaccttcggg      300

gctggcacca agctggagct gaagcgcgct gccgccgccc ccagtgtctt cattttcccc      360

ccttccgatg agcagctgaa gagcggtaca gcctctgttg tttgtctgct gaacaacttc      420

tatccacgcg aggccaaggt gcagtggaaa gttgataacg cgctgcagag tggcaactcc      480

caggagtctg tgacagagca ggacagtaaa gacagcacat attccctgtc tagcacactg      540

actctgtcca aggctgacta tgagaagcac aaggtgtacg cttgcgaggt cacccaccag      600

ggactgagtt ctcctgtgac caagtccttc aatcgcggcg agtgt                      645


<210>  195
<211>  654
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Made in Lab - antibody fragment

<400>  195
gatattcaga tgacccagag cccgagcagc ctgagcgcga gcgtgggcga tcgcgtgacc       60

attacctgcc gcgcgagcga aagcgtggat aactatggca ttagctttat gaactggttt      120

cagcagaaac cgggcaaagc gccgaaactg ctgatttatg cggcgagcaa ccagggcagc      180

ggcgtgccga gccgctttag cggcagcggc agcggcaccg attttaccct gaacattagc      240

agcctgcagc cggatgattt tgcgacctat tattgccagc agagcaaaga agtgccgtgg      300

acctttggcc agggcaccaa agtggaaatt aaacgaactg tggctgcacc atctgtcttc      360

atcttcccgc catctgatga gcagttgaaa tctggaactg cctctgttgt gtgcctgctg      420

aataacttct atcccagaga ggccaaagta cagtggaagg tggataacgc cctccaatcg      480

ggtaactccc aggagagtgt cacagagcag gacagcaagg acagcaccta cagcctcagc      540

agcaccctga cgctgagcaa agcagactac gagaaacaca aagtctacgc ctgcgaagtc      600

acccatcagg gcctgagctc gcccgtcaca aagagcttca acaggggaga gtgt            654


<210>  196
<211>  690
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Made in Lab - antibody fragment

<400>  196
caggtgcagc tggtgcagag cggcgcggaa gtgaaaaaac cgggcagcag cgtgaaagtg       60

agctgcaaag cgagcggcta tacctttacc gattataaca tgcattgggt gcgccaggcg      120

ccgggccagg gcctggaatg gattggctat atttatccgt ataacggcgg caccggctat      180

aaccagaaat ttaaaagcaa agcgaccatt accgcggatg aaagcaccaa caccgcgtat      240

atggaactga gcagcctgcg cagcgaagat accgcggtgt attattgcgc gcgcggccgc      300

ccggcgatgg attattgggg ccagggcacc ctggtgaccg tgagcagcgc ctccaccaag      360

ggcccatcgg tcttccccct ggcaccctcc tcctagagca cctctggggg cacagcggcc      420

ctgggctgcc tggtcaagga ctacttcccc gaaccggtga cggtgtcgtg gaactcaggc      480

gccctgacca gcggcgtgca caccttcccg gctgtcctac agtcctcagg actctactcc      540

ctcagcagcg tggtgaccgt gccctccagc agcttgggca cccagaccta catctgcaac      600

gtgaatcaca agcccagcaa caccaaggtc gacaagaaag ttgagcccaa atcttgtggt      660

ggcggtcacc atcaccatca tcaccaccac                                       690


<210>  197
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - antibody fragment

<400>  197

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Lys Ala Ser Gln Asp Val Gly Ile Ala 
            20                  25                  30          


Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Val Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Trp Ala Ser Thr Arg His Thr Gly Val Pro Asp Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Val Ala Thr Tyr Tyr Cys Gln Gln Tyr Ser Ser Tyr Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  198
<211>  222
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - antibody fragment

<400>  198

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Asp Phe Ser Arg Tyr 
            20                  25                  30          


Trp Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Glu Ile Asn Pro Asp Ser Ser Thr Ile Asn Tyr Ala Pro Ser Leu 
    50                  55                  60                  


Lys Asp Lys Phe Ile Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Pro Asp Gly Asn Tyr Trp Tyr Phe Asp Val Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe 
        115                 120                 125             


Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu 
    130                 135                 140                 


Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp 
145                 150                 155                 160 


Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu 
                165                 170                 175     


Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser 
            180                 185                 190         


Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro 
        195                 200                 205             


Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys 
    210                 215                 220         


<210>  199
<211>  214
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - antibody fragment

<400>  199

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Met Ser Val Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys His Ser Ser Gln Asp Ile Asn Ser Asn 
            20                  25                  30          


Ile Gly Trp Leu Gln Gln Lys Pro Gly Lys Ser Phe Lys Gly Leu Ile 
        35                  40                  45              


Tyr His Gly Thr Asn Leu Asp Asp Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Tyr Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Val Gln Tyr Ala Gln Phe Pro Trp 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg Thr Val Ala Ala 
            100                 105                 110         


Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             


Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 


Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 


Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     


Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         


Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             


Phe Asn Arg Gly Glu Cys 
    210                 


<210>  200
<211>  217
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - antibody fragment

<400>  200

Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gln Thr Leu 
1               5                   10                  15      


Ser Leu Thr Cys Thr Val Ser Gly Tyr Ser Ile Ser Ser Asp Phe Ala 
            20                  25                  30          


Trp Asn Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Met Gly 
        35                  40                  45              


Tyr Ile Ser Tyr Ser Gly Asn Thr Arg Tyr Gln Pro Ser Leu Lys Ser 
    50                  55                  60                  


Arg Ile Thr Ile Ser Arg Asp Thr Ser Lys Asn Gln Phe Phe Leu Lys 
65                  70                  75                  80  


Leu Asn Ser Val Thr Ala Ala Asp Thr Ala Thr Tyr Tyr Cys Val Thr 
                85                  90                  95      


Ala Gly Arg Gly Phe Pro Tyr Trp Gly Gln Gly Thr Leu Val Thr Val 
            100                 105                 110         


Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser 
        115                 120                 125             


Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys 
    130                 135                 140                 


Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu 
145                 150                 155                 160 


Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu 
                165                 170                 175     


Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr 
            180                 185                 190         


Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val 
        195                 200                 205             


Asp Lys Lys Val Glu Pro Lys Ser Cys 
    210                 215         


<210>  201
<211>  214
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - antibody fragment

<400>  201

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Asn Gln Gly Ile Ser Asn Asn 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Pro Leu Ile 
        35                  40                  45              


Tyr Tyr Thr Ser Asn Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Tyr Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Phe Thr Ser Leu Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys Arg Thr Val Ala Ala 
            100                 105                 110         


Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             


Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 


Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 


Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     


Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         


Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             


Phe Asn Arg Gly Glu Cys 
    210                 


<210>  202
<211>  224
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - antibody fragment

<400>  202

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Phe 
            20                  25                  30          


Asp Met Ala Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Val Trp Val 
        35                  40                  45              


Ser Ser Ile Thr Thr Gly Gly Gly Asp Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Ser Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asp Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Val Arg His Gly Tyr Tyr Asp Gly Tyr His Leu Phe Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser 
        115                 120                 125             


Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala 
    130                 135                 140                 


Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val 
145                 150                 155                 160 


Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala 
                165                 170                 175     


Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val 
            180                 185                 190         


Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His 
        195                 200                 205             


Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys 
    210                 215                 220                 


<210>  203
<211>  214
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - antibody fragment

<400>  203

Asp Ile Gln Met Thr Gln Thr Thr Ser Ser Leu Ser Ala Ser Leu Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Ser Cys Arg Ala Ser Gln Asp Ile Ser Lys Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Asp Gly Thr Val Lys Leu Leu Ile 
        35                  40                  45              


Tyr His Thr Ser Arg Leu His Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Tyr Ser Leu Thr Ile Ser Asn Leu Glu Gln 
65                  70                  75                  80  


Glu Asp Ile Ala Thr Tyr Phe Cys Gln Gln Gly Asn Thr Leu Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg Thr Val Ala Ala 
            100                 105                 110         


Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             


Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 


Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 


Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     


Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         


Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             


Phe Asn Arg Gly Glu Cys 
    210                 


<210>  204
<211>  449
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - antibody fragment

<400>  204

Glu Val Lys Leu Gln Glu Ser Gly Pro Gly Leu Val Ala Pro Ser Gln 
1               5                   10                  15      


Ser Leu Ser Val Thr Cys Thr Val Ser Gly Val Ser Leu Pro Asp Tyr 
            20                  25                  30          


Gly Val Ser Trp Ile Arg Gln Pro Pro Arg Lys Gly Leu Glu Trp Leu 
        35                  40                  45              


Gly Val Ile Trp Gly Ser Glu Thr Thr Tyr Tyr Asn Ser Ala Leu Lys 
    50                  55                  60                  


Ser Arg Leu Thr Ile Ile Lys Asp Asn Ser Lys Ser Gln Val Phe Leu 
65                  70                  75                  80  


Lys Met Asn Ser Leu Gln Thr Asp Asp Thr Ala Ile Tyr Tyr Cys Ala 
                85                  90                  95      


Lys His Tyr Tyr Tyr Gly Gly Ser Tyr Ala Met Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Ser Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val 
        115                 120                 125             


Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala 
    130                 135                 140                 


Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser 
145                 150                 155                 160 


Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val 
                165                 170                 175     


Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro 
            180                 185                 190         


Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys 
        195                 200                 205             


Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp 
    210                 215                 220                 


Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Pro Val Ala Gly Pro 
225                 230                 235                 240 


Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser 
                245                 250                 255     


Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp 
            260                 265                 270         


Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn 
        275                 280                 285             


Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val 
    290                 295                 300                 


Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu 
305                 310                 315                 320 


Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys 
                325                 330                 335     


Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr 
            340                 345                 350         


Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr 
        355                 360                 365             


Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu 
    370                 375                 380                 


Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu 
385                 390                 395                 400 


Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys 
                405                 410                 415     


Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu 
            420                 425                 430         


Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
        435                 440                 445             


Lys 
    


<210>  205
<211>  223
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - antibody fragment

<400>  205

Glu Val Lys Leu Gln Glu Ser Gly Pro Gly Leu Val Ala Pro Ser Gln 
1               5                   10                  15      


Ser Leu Ser Val Thr Cys Thr Val Ser Gly Val Ser Leu Pro Asp Tyr 
            20                  25                  30          


Gly Val Ser Trp Ile Arg Gln Pro Pro Arg Lys Gly Leu Glu Trp Leu 
        35                  40                  45              


Gly Val Ile Trp Gly Ser Glu Thr Thr Tyr Tyr Asn Ser Ala Leu Lys 
    50                  55                  60                  


Ser Arg Leu Thr Ile Ile Lys Asp Asn Ser Lys Ser Gln Val Phe Leu 
65                  70                  75                  80  


Lys Met Asn Ser Leu Gln Thr Asp Asp Thr Ala Ile Tyr Tyr Cys Ala 
                85                  90                  95      


Lys His Tyr Tyr Tyr Gly Gly Ser Tyr Ala Met Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Ser Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val 
        115                 120                 125             


Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala 
    130                 135                 140                 


Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser 
145                 150                 155                 160 


Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val 
                165                 170                 175     


Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro 
            180                 185                 190         


Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys 
        195                 200                 205             


Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys 
    210                 215                 220             


<210>  206
<211>  450
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - antibody fragment

<400>  206

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Phe 
            20                  25                  30          


Asp Met Ala Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Val Trp Val 
        35                  40                  45              


Ser Ser Ile Thr Thr Gly Gly Gly Asp Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Ser Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asp Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Val Arg His Gly Tyr Tyr Asp Gly Tyr His Leu Phe Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser 
        115                 120                 125             


Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala 
    130                 135                 140                 


Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val 
145                 150                 155                 160 


Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala 
                165                 170                 175     


Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val 
            180                 185                 190         


Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His 
        195                 200                 205             


Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys 
    210                 215                 220                 


Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Pro Val Ala Gly 
225                 230                 235                 240 


Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile 
                245                 250                 255     


Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu 
            260                 265                 270         


Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His 
        275                 280                 285             


Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg 
    290                 295                 300                 


Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys 
305                 310                 315                 320 


Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu 
                325                 330                 335     


Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr 
            340                 345                 350         


Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu 
        355                 360                 365             


Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp 
    370                 375                 380                 


Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val 
385                 390                 395                 400 


Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp 
                405                 410                 415     


Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His 
            420                 425                 430         


Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro 
        435                 440                 445             


Gly Lys 
    450 


<210>  207
<211>  4137
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Made in Lab - antibody fragment

<400>  207
ggatctgcga tcgctccggt gcccgtcagt gggcagagcg cacatcgccc acagtccccg       60

agaagttggg gggaggggtc ggcaattgaa cgggtgccta gagaaggtgg cgcggggtaa      120

actgggaaag tgatgtcgtg tactggctcc gcctttttcc cgagggtggg ggagaaccgt      180

atataagtgc agtagtcgcc gtgaacgttc tttttcgcaa cgggtttgcc gccagaacac      240

agctgaagct tcgaggggct cgcatctctc cttcacgcgc ccgccgccct acctgaggcc      300

gccatccacg ccggttgagt cgcgttctgc cgcctcccgc ctgtggtgcc tcctgaactg      360

cgtccgccgt ctaggtaagt ttaaagctca ggtcgagacc gggcctttgt ccggcgctcc      420

cttggagcct acctagactc agccggctct ccacgctttg cctgaccctg cttgctcaac      480

tctacgtctt tgtttcgttt tctgttctgc gccgttacag atccaagctg tgaccggcgc      540

ctacctgaga tcaccggcga aggagggcca ccatgtacag gatgcaactc ctgtcttgca      600

ttgcactaag tcttgcactt gtcacgaatt cggacattca gctgacccag tctccagctt      660

ccctgtctac atctctggga gaaactgtca ccatccaatg tcaagcaagt gaggacattt      720

acagtggttt agcgtggtat cagcagaagc cagggaaatc tcctcagctc ctgatctatg      780

gtgcaagtga cttacaagac ggcgtcccat cacgattcag tggcagtgga tctggcacac      840

agtattctct caagatcacc agcatgcaaa ctgaagatga aggggtttat ttctgtcaac      900

agggtttaac gtatcctcgg acgttcggtg gcggcaccaa gctggaaatc aaacgaactg      960

tggctgcacc atctgtcttc atcttcccgc catctgatga gcagttgaaa tctggaactg     1020

cctctgtcgt gtgcctgctg aataacttct atcccagaga ggccaaagta cagtggaagg     1080

tggataacgc cctccaatcg ggtaactccc aggagagtgt cacagagcag gacagcaagg     1140

acagcaccta cagcctcagc agcaccctga cgctgagcaa agcagactac gagaaacaca     1200

aagtctacgc ctgcgaagtc acccatcagg gcctgtcctc gcccgtcaca aagagcttca     1260

acaggggaga gtgttgataa gtgctagctg gccagacatg ataagataca ttgatgagtt     1320

tggacaaacc acaactagaa tgcagtgaaa aaaatgcttt atttgtgaaa tttgtgatgc     1380

tattgcttta tttgtaacca ttataagctg caataaacaa gttaacaaca acaattgcat     1440

tcattttatg tttcaggttc agggggaggt gtgggaggtt ttttaaagca agtaaaacct     1500

ctacaaatgt ggtatggaat taattctaaa atacagcata gcaaaacttt aacctccaaa     1560

tcaagcctct acttgaatcc ttttctgagg gatgaataag gcataggcat caggggctgt     1620

tgccaatgtg cattagctgt ttgcagcctc accttctttc atggagttta agatatagtg     1680

tattttccca aggtttgaac tagctcttca tttctttatg ttttaaatgc actgacctcc     1740

cacattccct ttttagtaaa atattcagaa ataatttaaa tacatcattg caatgaaaat     1800

aaatgttttt tattaggcag aatccagatg ctcaaggccc ttcataatat cccccagttt     1860

agtagttgga cttagggaac aaaggaacct ttaatagaaa ttggacagca agaaagcgag     1920

cttctagctt atcctcagtc ctgctcctct gccacaaagt gcacgcagtt gccggccggg     1980

tcgcgcaggg cgaactcccg cccccacggc tgctcgccga tctcggtcat ggccggcccg     2040

gaggcgtccc ggaagttcgt ggacacgacc tccgaccact cggcgtacag ctcgtccagg     2100

ccgcgcaccc acacccaggc cagggtgttg tccggcacca cctggtcctg gaccgcgctg     2160

atgaacaggg tcacgtcgtc ccggaccaca ccggcgaagt cgtcctccac gaagtcccgg     2220

gagaacccga gccggtcggt ccagaactcg accgctccgg cgacgtcgcg cgcggtgagc     2280

accggaacgg cactggtcaa cttggccatg atggctcctc ctgtcaggag aggaaagaga     2340

agaaggttag tacaattgct atagtgagtt gtattatact atgcagatat actatgccaa     2400

tgattaattg tcaaactagg gctgcagggt tcatagtgcc acttttcctg cactgcccca     2460

tctcctgccc accctttccc aggcatagac agtcagtgac ttaccaaact cacaggaggg     2520

agaaggcaga agcttgagac agacccgcgg gaccgccgaa ctgcgagggg acgtggctag     2580

ggcggcttct tttatggtgc gccggccctc ggaggcaggg cgctcgggga ggcctagcgg     2640

ccaatctgcg gtggcaggag gcggggccga aggccgtgcc tgaccaatcc ggagcacata     2700

ggagtctcag ccccccgccc caaagcaagg ggaagtcacg cgcctgtagc gccagcgtgt     2760

tgtgaaatgg gggcttgggg gggttggggc cctgactagt caaaacaaac tcccattgac     2820

gtcaatgggg tggagacttg gaaatccccg tgagtcaaac cgctatccac gcccattgat     2880

gtactgccaa aaccgcatca tcatggtaat agcgatgact aatacgtaga tgtactgcca     2940

agtaggaaag tcccataagg tcatgtactg ggcataatgc caggcgggcc atttaccgtc     3000

attgacgtca atagggggcg tacttggcat atgatacact tgatgtactg ccaagtgggc     3060

agtttaccgt aaatactcca cccattgacg tcaatggaaa gtccctattg gcgttactat     3120

gggaacatac gtcattattg acgtcaatgg gcgggggtcg ttgggcggtc agccaggcgg     3180

gccatttacc gtaagttatg taacgcctgc aggttaatta agaacatgtg agcaaaaggc     3240

cagcaaaagg ccaggaaccg taaaaaggcc gcgttgctgg cgtttttcca taggctccgc     3300

ccccctgacg agcatcacaa aaatcgacgc tcaagtcaga ggtggcgaaa cccgacagga     3360

ctataaagat accaggcgtt tccccctgga agctccctcg tgcgctctcc tgttccgacc     3420

ctgccgctta ccggatacct gtccgccttt ctcccttcgg gaagcgtggc gctttctcat     3480

agctcacgct gtaggtatct cagttcggtg taggtcgttc gctccaagct gggctgtgtg     3540

cacgaacccc ccgttcagcc cgaccgctgc gccttatccg gtaactatcg tcttgagtcc     3600

aacccggtaa gacacgactt atcgccactg gcagcagcca ctggtaacag gattagcaga     3660

gcgaggtatg taggcggtgc tacagagttc ttgaagtggt ggcctaacta cggctacact     3720

agaagaacag tatttggtat ctgcgctctg ctgaagccag ttaccttcgg aaaaagagtt     3780

ggtagctctt gatccggcaa acaaaccacc gctggtagcg gtggtttttt tgtttgcaag     3840

cagcagatta cgcgcagaaa aaaaggatct caagaagatc ctttgatctt ttctacgggg     3900

tctgacgctc agtggaacga aaactcacgt taagggattt tggtcatggc tagttaatta     3960

acatttaaat cagcggccgc aataaaatat ctttattttc attacatctg tgtgttggtt     4020

ttttgtgtga atcgtaacta acatacgctc tccatcaaaa caaaacgaaa caaaacaaac     4080

tagcaaaata ggctgtcccc agtgcaagtg caggtgccag aacatttctc tatcgaa        4137


<210>  208
<211>  4152
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Made in Lab - antibody fragment

<400>  208
ggatctgcga tcgctccggt gcccgtcagt gggcagagcg cacatcgccc acagtccccg       60

agaagttggg gggaggggtc ggcaattgaa cgggtgccta gagaaggtgg cgcggggtaa      120

actgggaaag tgatgtcgtg tactggctcc gcctttttcc cgagggtggg ggagaaccgt      180

atataagtgc agtagtcgcc gtgaacgttc tttttcgcaa cgggtttgcc gccagaacac      240

agctgaagct tcgaggggct cgcatctctc cttcacgcgc ccgccgccct acctgaggcc      300

gccatccacg ccggttgagt cgcgttctgc cgcctcccgc ctgtggtgcc tcctgaactg      360

cgtccgccgt ctaggtaagt ttaaagctca ggtcgagacc gggcctttgt ccggcgctcc      420

cttggagcct acctagactc agccggctct ccacgctttg cctgaccctg cttgctcaac      480

tctacgtctt tgtttcgttt tctgttctgc gccgttacag atccaagctg tgaccggcgc      540

ctacctgaga tcaccggcga aggagggcca ccatgtacag gatgcaactc ctgtcttgca      600

ttgcactaag tcttgcactt gtcacgaatt cgcaagtgca gctggtgcag tctggggctg      660

agcttgtgag acctgggacc tctgtgaagt tatcttgcaa agtttctggc gataccatta      720

cattttacta catgcacttt gtgaagcaaa ggcctggaca gggtctggaa tggataggaa      780

ggattgatcc tgaggatgaa agtactaaat attctgagaa gttcaaaaac aaggcgacac      840

tcactgcaga tacatcttcc aacacagcct acctgaagct cagcagcctg acctctgagg      900

acactgcaac ctatttttgt atctacggag gatactactt tgattactgg ggcccaggaa      960

ccatggtcac cgtgtcctca gcctccacca agggcccatc ggtcttcccc ctggcaccct     1020

cctccaagag cacctctggg ggcacagcgg ccctgggctg cctggtcaag gactacttcc     1080

ccgaaccggt gacggtgtcg tggaactcag gcgccctgac cagcggcgtg cacaccttcc     1140

cggctgtcct acagtcctca ggactctact ccctcagcag cgtggtgact gtgccctcta     1200

gcagcttggg cacccagacc tacatctgca acgtgaatca caagcccagc aacaccaagg     1260

tggacaagaa agttgagccc aaatcttgtt gataagtgct agctggccag acatgataag     1320

atacattgat gagtttggac aaaccacaac tagaatgcag tgaaaaaaat gctttatttg     1380

tgaaatttgt gatgctattg ctttatttgt aaccattata agctgcaata aacaagttaa     1440

caacaacaat tgcattcatt ttatgtttca ggttcagggg gaggtgtggg aggtttttta     1500

aagcaagtaa aacctctaca aatgtggtat ggaattaatt ctaaaataca gcatagcaaa     1560

actttaacct ccaaatcaag cctctacttg aatccttttc tgagggatga ataaggcata     1620

ggcatcaggg gctgttgcca atgtgcatta gctgtttgca gcctcacctt ctttcatgga     1680

gtttaagata tagtgtattt tcccaaggtt tgaactagct cttcatttct ttatgtttta     1740

aatgcactga cctcccacat tcccttttta gtaaaatatt cagaaataat ttaaatacat     1800

cattgcaatg aaaataaatg ttttttatta ggcagaatcc agatgctcaa ggcccttcat     1860

aatatccccc agtttagtag ttggacttag ggaacaaagg aacctttaat agaaattgga     1920

cagcaagaaa gcgagcttct agcttatcct cagtcctgct cctctgccac aaagtgcacg     1980

cagttgccgg ccgggtcgcg cagggcgaac tcccgccccc acggctgctc gccgatctcg     2040

gtcatggccg gcccggaggc gtcccggaag ttcgtggaca cgacctccga ccactcggcg     2100

tacagctcgt ccaggccgcg cacccacacc caggccaggg tgttgtccgg caccacctgg     2160

tcctggaccg cgctgatgaa cagggtcacg tcgtcccgga ccacaccggc gaagtcgtcc     2220

tccacgaagt cccgggagaa cccgagccgg tcggtccaga actcgaccgc tccggcgacg     2280

tcgcgcgcgg tgagcaccgg aacggcactg gtcaacttgg ccatgatggc tcctcctgtc     2340

aggagaggaa agagaagaag gttagtacaa ttgctatagt gagttgtatt atactatgca     2400

gatatactat gccaatgatt aattgtcaaa ctagggctgc agggttcata gtgccacttt     2460

tcctgcactg ccccatctcc tgcccaccct ttcccaggca tagacagtca gtgacttacc     2520

aaactcacag gagggagaag gcagaagctt gagacagacc cgcgggaccg ccgaactgcg     2580

aggggacgtg gctagggcgg cttcttttat ggtgcgccgg ccctcggagg cagggcgctc     2640

ggggaggcct agcggccaat ctgcggtggc aggaggcggg gccgaaggcc gtgcctgacc     2700

aatccggagc acataggagt ctcagccccc cgccccaaag caaggggaag tcacgcgcct     2760

gtagcgccag cgtgttgtga aatgggggct tgggggggtt ggggccctga ctagtcaaaa     2820

caaactccca ttgacgtcaa tggggtggag acttggaaat ccccgtgagt caaaccgcta     2880

tccacgccca ttgatgtact gccaaaaccg catcatcatg gtaatagcga tgactaatac     2940

gtagatgtac tgccaagtag gaaagtccca taaggtcatg tactgggcat aatgccaggc     3000

gggccattta ccgtcattga cgtcaatagg gggcgtactt ggcatatgat acacttgatg     3060

tactgccaag tgggcagttt accgtaaata ctccacccat tgacgtcaat ggaaagtccc     3120

tattggcgtt actatgggaa catacgtcat tattgacgtc aatgggcggg ggtcgttggg     3180

cggtcagcca ggcgggccat ttaccgtaag ttatgtaacg cctgcaggtt aattaagaac     3240

atgtgagcaa aaggccagca aaaggccagg aaccgtaaaa aggccgcgtt gctggcgttt     3300

ttccataggc tccgcccccc tgacgagcat cacaaaaatc gacgctcaag tcagaggtgg     3360

cgaaacccga caggactata aagataccag gcgtttcccc ctggaagctc cctcgtgcgc     3420

tctcctgttc cgaccctgcc gcttaccgga tacctgtccg cctttctccc ttcgggaagc     3480

gtggcgcttt ctcatagctc acgctgtagg tatctcagtt cggtgtaggt cgttcgctcc     3540

aagctgggct gtgtgcacga accccccgtt cagcccgacc gctgcgcctt atccggtaac     3600

tatcgtcttg agtccaaccc ggtaagacac gacttatcgc cactggcagc agccactggt     3660

aacaggatta gcagagcgag gtatgtaggc ggtgctacag agttcttgaa gtggtggcct     3720

aactacggct acactagaag aacagtattt ggtatctgcg ctctgctgaa gccagttacc     3780

ttcggaaaaa gagttggtag ctcttgatcc ggcaaacaaa ccaccgctgg tagcggtggt     3840

ttttttgttt gcaagcagca gattacgcgc agaaaaaaag gatctcaaga agatcctttg     3900

atcttttcta cggggtctga cgctcagtgg aacgaaaact cacgttaagg gattttggtc     3960

atggctagtt aattaacatt taaatcagcg gccgcaataa aatatcttta ttttcattac     4020

atctgtgtgt tggttttttg tgtgaatcgt aactaacata cgctctccat caaaacaaaa     4080

cgaaacaaaa caaactagca aaataggctg tccccagtgc aagtgcaggt gccagaacat     4140

ttctctatcg aa                                                         4152


<210>  209
<211>  681
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Made in Lab - antibody fragment

<400>  209
caggtacagc tgcagcagtc aggtccagga ctggtgaagc cctcgcagac cctctcactc       60

acctgtgcca tctccgggga cagtgtctct agcaacagtg ctgcttggaa ctggatcagg      120

cagtccccat cgagaggcct tgagtggctg ggaaggacat actacaggtc caagtggtat      180

aatgattatg cagtatctgt gaaaagtcga ataaccatca acccagacac atccaagaac      240

cagttctccc tgcagctgaa ctctgtgact cccgaggaca cggctgtgta ttactgtgca      300

agagaagtga ctggggatct cgaggatgct tttgatatct ggggccaagg gacaatggtc      360

accgtctcct cagcctccac caagggccca tcggtcttcc ccctggcacc ctcctccaag      420

agcacctctg ggggcacagc ggccctgggc tgcctggtca aggactactt ccccgaaccg      480

gtgacggtgt cgtggaactc aggcgccctg accagcggcg tgcacacctt cccggctgtc      540

ctacagtcct caggactcta ctccctcagc agcgtggtga ctgtgccctc tagcagcttg      600

ggcacccaga cctacatctg caacgtgaat cacaagccca gcaacaccaa ggtggacaag      660

aaagttgagc ccaaatcttg t                                                681


<210>  210
<211>  642
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Made in Lab - antibody fragment

<400>  210
gacatccaga tgacccagtc tccatcgtcc ctgtctgcat ctgtaggaga cagagtcacc       60

atcacttgcc gggcaagcca gaccatttgg agctacttaa attggtatca gcagagacca      120

gggaaagccc ctaacctcct gatctatgct gcatccagtt tgcaaagtgg ggtcccatca      180

aggttcagtg gcaggggatc tgggacagat ttcactctca ccatcagcag tctgcaagct      240

gaagattttg caacttacta ctgtcaacag agttacagta tccctcagac ttttggccag      300

gggaccaagc tggagatcaa acgaactgtg gctgcaccat ctgtcttcat cttcccgcca      360

tctgatgagc agttgaaatc tggaactgcc tctgtcgtgt gcctgctgaa taacttctat      420

cccagagagg ccaaagtaca gtggaaggtg gataacgccc tccaatcggg taactcccag      480

gagagtgtca cagagcagga cagcaaggac agcacctaca gcctcagcag caccctgacg      540

ctgagcaaag cagactacga gaaacacaaa gtctacgcct gcgaagtcac ccatcagggc      600

ctgtcctcgc ccgtcacaaa gagcttcaac aggggagagt gt                         642


<210>  211
<211>  660
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Made in Lab - antibody fragment

<400>  211
gaggtgcaac tcgttcagag cgggggcggc gtcgtcaggc ctggcggctc cctccgtctg       60

ccttgtgctg cctccggctt taccttcgac gattacggaa tgtcctgggt tcgccaggct      120

cctggcaagg gtctggagtg ggtctctggc atcaactgga atggcggcag caccggttat      180

gctgacagtg tgaaggggag gttcacaatt agccgggaca atgccaagaa cagcctgtac      240

ctgcagatga actccctgcg tgctgaggac accgctctgt atcactgcgc gagaggcggt      300

gacgacgcct ttgacatttg gggccagggt accatggtta cagtgagctc tgctagcacc      360

aagggcccga gcgtcttccc tctggccccc agctctaaat ctacttccgg gggcaccgcc      420

gccctcgggt gcctggtgaa ggactatttc cctgagcctg tgacagtgag ctggaactcc      480

ggagcattga cttctggtgt gcacactttc cccgctgtgc tgcagtcctc tggactgtat      540

tccctgtcct ccgtggtgac tgtcccaagc tcctctctgg ggacacagac atacatctgt      600

aatgtgaacc acaaaccgtc caacactaag gtggacaaga aagtggaacc aaagtcttgt      660


<210>  212
<211>  645
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Made in Lab - antibody fragment

<400>  212
cggatcgtta tgacacagtc cccgggcacc ctgagcgtca gccccggaga gaccgctaca       60

ctctcctgca gggcctccca gtcttttagc aacatgctcg cgtggtacca acagaagagc      120

ggacaaccac ctcgcctgct catttatggc gtttctaccc gggcagctgg ggtgcctgcg      180

cggttctctg gctccgggtc cggaactgag tttactctga caattagcaa cctccaatcc      240

gaggactttg ctgtctacta ctgtcaacaa tacggagact ggccgcgcta cacctttggc      300

caagggacta aagtggaaag aaagcgtaca gttgccgctc ctagcgtctt catcttcccc      360

ccctctgatg agcagttgaa gtccggaacc gcctccgtgg tgtgtctgct gaacaacttc      420

tacccccgcg aggctaaggt gcagtggaag gtcgataacg ccttgcaatc tgggaactct      480

caggaaagcg tgacagagca ggactccaaa gacagcacct atagcctgag ctctactctg      540

accctgagca aggctgacta cgagaaacat aaggtttacg catgcgaggt gacccaccag      600

ggactgagta gtcctgtcac caagagtttc aatcgtggcg aatgt                      645


<210>  213
<211>  672
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Made in Lab - antibody fragment

<400>  213
gaagtgcaac tgcagcagtc cgggactgtg ctggcccgtc ccggagcaag cgtcaagatg       60

agctgtaagg cgtctgggta caggttcacc aattactgga tccactgggt gaaacaaagg      120

ccaggtcagg gtctggaatg gattggtggc atcaacccag gaaataacta taccacttac      180

aaacgtaacc tgaaaggcaa ggccaccctg actgccgtta caagcgccag cactgcttat      240

atggatctga gcagtctcac ctccgaggat tccgctgtgt actactgcac acgcgaaggc      300

tacggtaact atggcgcctg gttcgcctac tggggccagg gcaccttggt taccgtgtcc      360

tctgcgtcca ccaagggacc aagcgtgttt cccctcgccc caagcagcaa gagcacttct      420

ggcggcactg cggctttggg ctgcctggtc aaagattact ttcccgagcc cgttaccgtg      480

agctggaact ccggagctct gacctccggc gttcatacct ttccggcggt gctgcagtcc      540

tctggcctgt attctctgtc ctctgtcgtc accgttcctt cctcctccct cggaacccaa      600

acctacatct gtaacgtgaa ccacaaaccc tctaacacaa aggttgacaa gaaggttgag      660

ccaaaatcct gt                                                          672


<210>  214
<211>  657
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Made in Lab - antibody fragment

<400>  214
gatgtggtcg tgacccagac tccactgtct ctgcctgtga gtttcggtga ccaagtcagc       60

atttcttgca gaagttctca atccctggct aactcttacg gtaacacctt tctgtcttgg      120

tatctggaca aacctggcga gagccctcag ctgctgatct acggcatcag caaccggttc      180

agcggtgtcc ccgaccgctt caccggttct ggctccggca ctgacttcac actgaagatc      240

tctactatca aaccagaaga cttgggcatg tactattgtt tggaaggcac ccaccagcca      300

tatactttcg gtggcggcac aaagctggag atcaaacgca ccgtcgccgc cccttccgtg      360

ttcatctttc ctccttccga cgaacagctg aagagtggca cagcatctgt ggtctgcctg      420

ctgaacaatt tctaccctag agaggccaag gtccagtgga aggtggacaa tgcactccag      480

tccgggaact ctcaggagag tgtgacagag caggattcta aggattccac ttactccctg      540

agctctacat tgactctgtc caaagccgac tacgaaaagc ataaggttta cgcgtgtgaa      600

gtgacccacc agggcctgtc cagccctgtg accaagagtt ttaaccgggg ggagtgc         657


<210>  215
<211>  672
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Made in Lab - antibody fragment

<400>  215
caggtgcagc tgcagcagcc gggcgcggaa ctggtgaaac cgggcgcgag cgtgaaaatg       60

agctgcaaag cgagcggcta tacctttacc agctataaca tgcattgggt gaaacagacc      120

ccgggccgcg gcctggaatg gattggcgcg atttatccgg gcaacggcga taccagctat      180

aaccagaaat ttaaaggcaa agcgaccctg accgcggata aaagcagcag caccgcgtat      240

atgcagctga gcagcctgac cagcgaagat agcgcggtgt attattgcgc gcgcagcacc      300

tattatggcg gcgattggta ttttaacgtg tggggcgcgg gcaccaccgt gaccgtgagc      360

gcggcgagca ccaagggccc atcggtcttc cccctggcac cctcctccaa gagcacctct      420

gggggcacag cggccctggg ctgcctggtc aaggactact tccccgaacc ggtgacggtg      480

tcgtggaact caggcgccct gaccagcggc gtgcacacct tcccggctgt cctacagtcc      540

tcaggactct actccctcag cagcgtggtg actgtgccct ctagcagctt gggcacccag      600

acctacatct gcaacgtgaa tcacaagccc agcaacacca aggtggacaa gaaagttgag      660

cccaaatctt gt                                                          672


<210>  216
<211>  639
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Made in Lab - antibody fragment

<400>  216
cagattgtgc tgagccagag cccggcgatt ctgagcgcga gcccgggcga aaaagtgacc       60

atgacctgcc gcgcgagcag cagcgtgagc tatattcatt ggtttcagca gaaaccgggc      120

agcagcccga aaccgtggat ttatgcgacc agcaacctgg cgagcggcgt gccggtgcgc      180

tttagcggca gcggcagcgg caccagctat agcctgacca ttagccgcgt ggaagcggaa      240

gatgcggcga cctattattg ccagcagtgg accagcaacc cgccgacctt tggcggcggc      300

accaagcttg agatcaaacg aactgtggct gcaccatctg tcttcatctt cccgccatct      360

gatgagcagt tgaaatctgg aactgcctct gtcgtgtgcc tgctgaataa cttctatccc      420

agagaggcca aagtacagtg gaaggtggat aacgccctcc aatcgggtaa ctcccaggag      480

agtgtcacag agcaggacag caaggacagc acctacagcc tcagcagcac cctgacgctg      540

agcaaagcag actacgagaa acacaaagtc tacgcctgcg aagtcaccca tcagggcctg      600

tcctcgcccg tcacaaagag cttcaacagg ggagagtgt                             639


<210>  217
<211>  666
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Made in Lab - antibody fragment

<400>  217
caagtgcagc tcgtgcagag tggcgcagag gtgaagaaac ctggctcaag tgttaaggtg       60

tcctgtaagg ctagtggcta cgctttttct tacagttgga tcaactgggt tcgccaagcc      120

cccgggcagg gattggaatg gatgggcagg atctttccag gcgatggaga cactgactat      180

aacggcaagt ttaagggcag ggtgacaatc acggcggaca aaagcacaag cactgcctac      240

atggagctga gctcactgcg gtcagaggac acggctgtat attactgcgc caggaacgtg      300

ttcgatggct actggctggt gtattggggg cagggcacgc ttgtgactgt tagcagcgca      360

agtactaagg gtccatcagt gttcccactg gctccatcct ctaagtcaac gtctggcggt      420

acagcagctc ttggctgtct cgttaaggac tattttccgg agcctgtgac cgtcagttgg      480

aattctggcg cactgacgtc aggagtgcat acttttcctg ccgtcctgca gagttccgga      540

ctgtacagcc tttcctccgt cgtgactgtt ccatccagca gcctgggaac ccagacctat      600

atttgtaacg tgaaccacaa gccctcaaac accaaggttg acaagaaggt ggagcctaag      660

agttgt                                                                 666


<210>  218
<211>  666
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Made in Lab - antibody fragment

<400>  218
gatatagtaa tgacacaaac gcctctgtct cttcctgtca cgcccggcga accagcctcc       60

atatcctgca gatcatctaa aagtcttctc cactccaacg gaattacgta tttgtactgg      120

tatttgcaga agcctgggca gtctccccaa ctgctgattt atcagatgtc taacttggta      180

agcggggtgc ccgataggtt ttcagggtcc ggaagcggca cagatttcac gctgaagatc      240

agcagagtgg aagccgagga cgtgggcgtg tattattgcg cgcagaattt ggagctccca      300

tataccttcg gaggtgggac caaggtagaa atcaagcgaa ctgtcaggac tgtcgctgcc      360

ccgagcgttt tcatcttccc cccgtctgac gaacagctta aaagcggcac tgcaagcgtg      420

gtgtgcctgc ttaacaattt ctatcccaga gaagcgaagg ttcagtggaa ggtggataac      480

gccctgcaat ctggcaatag ccaggagtcc gttacagaac aagattcaaa agactcaacg      540

tactctctgt cctccacact gaccctgagc aaagctgatt acgaaaaaca taaggtttac      600

gcctgcgagg tcacacacca ggggctttct agtccggtga ctaaatcttt taaccgcggg      660

gaatgt                                                                 666


<210>  219
<211>  675
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Made in Lab - antibody fragment

<400>  219
gaggtgcagc tggtcgagtc aggcggaggc ctggttcagc cagggagatc cctcaggctt       60

tcctgcgccg cctccggttt taccttcaac gactacgcta tgcactgggt tcgccaggct      120

cccggaaagg gacttgaatg ggtgagcact atcagctgga attctggaag cattgggtat      180

gccgactccg tcaagggccg ctttactatt tctcgggata atgcgaagaa gtctctgtac      240

ctgcagatga acagtcttcg ggcagaagac acggctcttt actattgcgc aaaagacatc      300

cagtacggaa actattatta cggaatggat gtgtggggtc agggcaccac tgtgacagta      360

agcagtgcta gtacaaaggg accttctgtg tttccacttg ctcctagctc caaatccacg      420

tccgggggca ctgccgctct gggctgcctc gttaaagatt acttcccaga gcctgtcact      480

gtgtcctgga attccggcgc ccttacgtca ggggtacaca catttcccgc ggtactccag      540

tcaagcggct tgtacagcct gtcctccgta gtgacagtgc cttcctcttc tctcggcact      600

caaacttaca tctgcaatgt caatcacaaa ccgagtaaca ctaaggttga caagaaagtt      660

gaacctaaga gctgt                                                       675


<210>  220
<211>  642
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Made in Lab - antibody fragment

<400>  220
gaaatcgtcc tgacgcagtc acctgcaacc ctgagtctca gccctggtga gcgggccacc       60

ctgagctgca gggccagcca gagtgtatct tcttacctgg cttggtatca gcagaaacca      120

ggacaggccc caagactgct gatctacgac gcttccaata gagccacggg catccctgcc      180

cgattttccg gatcagggtc cggtacagat ttcacgctga ccatcagctc cctcgagccc      240

gaagattttg ctgtgtatta ttgccagcag cggtccaatt ggcccattac cttcggtcag      300

gggaccaggc tggagattaa acggaccgtg gctgctccct cagttttcat ctttccccca      360

tctgatgagc agctgaagtc cgggaccgca agcgtcgtgt gcctccttaa caatttttac      420

ccacgagaag ctaaggttca gtggaaggtg gataatgctc tccagtccgg taattctcag      480

gaatcagtga ccgaacagga tagcaaagat tctacctata gcttgtcatc aactctgacc      540

ctctccaaag ccgactacga gaaacacaaa gtctacgcat gcgaggtgac tcaccaaggt      600

ctgagttcac ccgttactaa aagctttaac agaggagaat gt                         642


<210>  221
<211>  672
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Made in Lab - antibody fragment

<400>  221
gaagttcagc tggttgaatc tggtggtggt ctggttcagc cgggtggttc tctgcgtctg       60

tcttgcgctg cttctggttt caccttctct aacttcgaca tggcttgggt tcgtcaggct      120

ccgggtaaag gtctggtttg ggtttcttct atcaccaccg gtggtggtga cacctactac      180

gctgactctg ttaaaggtcg tttcaccatc tctcgtgaca acgctaaatc taccctgtac      240

ctgcagatgg actctctgcg ttctgaagac accgctgttt actactgcgt tcgtcacggt      300

tactacgacg gttaccacct gttcgactac tggggtcagg gtaccctggt taccgtttct      360

tctgcctcca ccaagggccc atcggtcttc cccctggcac cctcctccaa gagcacctct      420

gggggcacag cggccctggg ctgcctggtc aaggactact tccccgaacc ggtgacggtg      480

tcgtggaact caggcgccct gaccagcggc gtgcacacct tcccggctgt cctacagtcc      540

tcaggactct actccctcag cagcgtggtg actgtgccct ctagcagctt gggcacccag      600

acctacatct gcaacgtgaa tcacaagccc agcaacacca aggtggacaa gaaagttgag      660

cccaaatctt gt                                                          672


<210>  222
<211>  642
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Made in Lab - antibody fragment

<400>  222
gacatccaga tgacccagtc tccgtcttct ctgtctgctt ctgttggtga ccgtgttacc       60

atcacctgcc gtgctaacca gggtatctct aacaacctga actggtacca gcagaaaccg      120

ggtaaagctc cgaaaccgct gatctactac acctctaacc tgcagtctgg tgttccgtct      180

cgtttctctg gttctggttc tggtaccgac tacaccctga ccatctcttc tctgcagccg      240

gaagacttcg ctacctacta ctgccagcag ttcacctctc tgccgtacac cttcggtcag      300

ggtaccaaac tggaaatcaa acgaactgtg gctgcaccat ctgtcttcat cttcccgcca      360

tctgatgagc agttgaaatc tggaactgcc tctgtcgtgt gcctgctgaa taacttctat      420

cccagagagg ccaaagtaca gtggaaggtg gataacgccc tccaatcggg taactcccag      480

gagagtgtca cagagcagga cagcaaagac agcacctaca gcctcagcag caccctgacg      540

ctgagcaaag cagactacga gaaacacaaa gtctacgcct gcgaagtcac ccatcagggc      600

ctgtcctcgc ccgtcacaaa gagcttcaac aggggagagt gt                         642


<210>  223
<211>  633
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Made in Lab - antibody fragment

<400>  223
gagattgtcc tgacccagtc ccctgctatt atgtctgctt cccccggcga aagagtgacc       60

atgacctgta gtgcctccag cggcgtcaac tacatgcact ggtatcagca gaagccaggg      120

acctctcccc ggagatggat ctacgacaca tcaaagctgg ccagcggagt gcctgcacgg      180

ttctccggat ctggcagtgg gactgactat agcctgacca tcagcagcat ggagccagaa      240

gatgccgcta cctactattg ccatcagagg ggctcctaca catttggcgg gggaactaag      300

ctggagatca aacgcacagt ggcagccccc agcgtcttca tttttccccc ttccgatgaa      360

cagctgaagt ccggcactgc ttctgtggtc tgtctgctga acaatttcta tcccagagag      420

gccaaggtgc agtggaaagt ggacaacgct ctgcagtccg gcaacagcca ggagagtgtg      480

accgaacagg atagtaagga cagcacatat tctctgtcta gtaccctgac actgagtaag      540

gcagattacg agaagcacaa agtgtatgcc tgcgaagtca ctcatcaggg actgtcaagc      600

cccgtgacca agagcttcaa ccggggcgag tgt                                   633


<210>  224
<211>  669
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Made in Lab - antibody fragment

<400>  224
caggtgcagc tggtccagcc aggggcagag gtcgtcaagc caggagcatc cgtcaaactg       60

tcatgtaaaa caagcgggta tactttcacc agcaattgga tgcactgggt gaagcaggcc      120

cccggacagg gcctggagtg gatcggggaa attgacccta gtgattcata cactaactac      180

aaccagaact tccagggaaa ggccaaactg accgtggaca aaagcacctc cacagcttat      240

atggaggtga gcagcctgcg gtccgacgat actgcagtct actattgcgc cagaggctct      300

aacccttact attacgctat ggattactgg gggcagggaa caagcgtgac tgtctctagt      360

gcatcaacaa agggaccaag cgtgtttcca ctggccccct caagcaagag cacctccgga      420

gggacagccg ctctgggatg tctggtgaaa gactacttcc ccgagcctgt gactgtctct      480

tggaatagtg gcgctctgac ctccggggtg cacacatttc cagcagtcct gcagtcctct      540

ggactgtatt ctctgagttc agtggtcacc gtgcccagct cctctctggg cactcagacc      600

tacatctgca atgtcaacca taagcctagt aacacaaaag tggataagaa agtcgaacca      660

aagagctgt                                                              669


<210>  225
<211>  672
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Made in Lab - antibody fragment

<400>  225
caggtccaac tgcaggagtc aggaggaggc ttggtacagc ctgggggttc tctgagactc       60

tcctgtgcaa cttctgggtt caccttcact gattactaca tgaactgggt ccgccagcct      120

ccaggaaagg cacttgagtg gttgggtttt attggaaaca aagctaatgg ttacacaaca      180

gagtacagtg catctgtgaa gggtcggttc accatctcca gagataaatc ccaaagcatc      240

ctctatcttc aaatgaacac cctgagagct gaggacagtg ccacttatta ctgtaccaga      300

gatagggggc tacggttcta ctttgactac tggggccaag ggaccacggt caccgtctcc      360

tcagcctcca ccaagggccc atcggtcttc cccctggcac cctcctccaa gagcacctct      420

gggggcacag cggccctggg ctgcctggtc aaggactact tccccgaacc ggtgacggtg      480

tcgtggaact caggcgccct gaccagcggc gtgcacacct tcccggctgt cctacagtcc      540

tcaggactct actccctcag cagcgtggtg actgtgccct ctagcagctt gggcacccag      600

acctacatct gcaacgtgaa tcacaagccc agcaacacca aggtggacaa gaaagttgag      660

cccaaatctt gt                                                          672


<210>  226
<211>  642
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Made in Lab - antibody fragment

<400>  226
gacattgagc tcacccagtc tccagcaatc ctgtctgcat ctccagggga gaaggtcaca       60

atgacttgca gggccagctc aagtgtaact tacattcact ggtaccagca gaagccagga      120

tcctccccca aatcctggat ttatgccaca tccaacctgg cttctggagt ccctgctcgc      180

ttcagtggca gtgggtctgg gacctcttac tctctcacaa tcagcagagt ggaggctgaa      240

gatgctgcca cttattactg ccaacattgg agtagtaaac caccgacgtt cggtggaggg      300

accaagctcg agatcaaaaa acgaactgtg gctgcaccat ctgtcttcat cttcccgcca      360

tctgatgagc agttgaaatc tggaactgcc tctgtcgtgt gcctgctgaa taacttctat      420

cccagagagg ccaaagtaca gtggaaggtg gataacgccc tccaatcggg taactcccag      480

gagagtgtca cagagcagga cagcaaggac agcacctaca gcctcagcag caccctgacg      540

ctgagcaaag cagactacga gaaacacaaa gtctacgcct gcgaagtcac ccatcagggc      600

ctgtcctcgc ccgtcacaaa gagcttcaac aggggagagt gt                         642


<210>  227

<400>  227
000

<210>  228

<400>  228
000

<210>  229

<400>  229
000

<210>  230

<400>  230
000

<210>  231

<400>  231
000

<210>  232

<400>  232
000

<210>  233
<211>  660
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Made in Lab - antibody fragment

<400>  233
gacatccagc tgacccagtc cccctcctcc ctgtccgcct ccgtgggcga ccgggtgacc       60

atgagctgca agtcctccca gtccgtgctg tactccgcca accacaagaa ctacctggcc      120

tggtaccagc agaagcccgg caaggccccc aagctgctga tctactgggc cagcacccgc      180

gagagcggcg tgccctcccg gttctccggc tccggctccg gcaccgactt caccttcacc      240

atctcctccc tgcagcccga ggacatcgcc acctactact gccaccagta cctgtcctcc      300

tggaccttcg gcggcggcac caagctggag atcaagcgca cggtggccgc ccccagtgtc      360

ttcattttcc ccccttccga tgagcagctg aagagcggta cagcctctgt tgtttgtctg      420

ctgaacaact tctatccacg cgaggccaag gtgcagtgga aagttgataa cgcgctgcag      480

agtggcaact cccaggagtc tgtgacagag caggacagta aagacagcac atattccctg      540

tctagcacac tgactctgtc caaggctgac tatgagaagc acaaggtgta cgcttgcgag      600

gtcacccacc agggactgag ttctcctgtg accaagtcct tcaatcgcgg cgagtgttaa      660


<210>  234
<211>  660
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Made in Lab - antibody fragment

<400>  234
caggtgcagc tggtgcagtc cggcgccgag gtgaagaagc ccggctcctc cgtgaaggtg       60

tcctgcaagg cctccggcta caccttcacc tcctactggc tgcactgggt gcggcaggcc      120

cccggccagg gcctggagtg gatcggctac atcaaccccc ggaacgacta caccgagtac      180

aaccagaact tcaaggacaa ggccaccatc accgccgacg agtccaccaa caccgcctac      240

atggagctgt cctccctgcg gtccgaggac accgccttct acttctgcgc ccggcgggac      300

atcaccacct tctactgggg ccagggcacc actgtgaccg tgtcctccgc caggaccaaa      360

ggaccgtccg tctttcctct ggccccttcc tctaagtcca caagcggtgg gaccgcagca      420

ctgggatgcc tggtgaagga ttacttccct gagccggtga ccgtgtcctg gaactccgga      480

gctctcacct ccggtgtcca tacctttcct gccgtcctgc agtcctccgg cctgtacagc      540

ctctctagcg tcgtgactgt gccctccagc tccctgggca cccaaactta tatctgcaat      600

gttaaccaca agccttctaa taccaaggtc gacaagaaag tggagccgaa gagctgttaa      660


<210>  235
<211>  1338
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Made in Lab - antibody fragment

<400>  235
caggtgcagc tggtgcagtc cggcgccgag gtgaagaagc ccggctcctc cgtgaaggtg       60

tcctgcaagg cctccggcta caccttcacc tcctactggc tgcactgggt gcggcaggcc      120

cccggccagg gcctggagtg gatcggctac atcaaccccc ggaacgacta caccgagtac      180

aaccagaact tcaaggacaa ggccaccatc accgccgacg agtccaccaa caccgcctac      240

atggagctgt cctccctgcg gtccgaggac accgccttct acttctgcgc ccggcgggac      300

atcaccacct tctactgggg ccagggcacc actgtgaccg tgtcctccgc caggaccaaa      360

ggaccgtccg tctttcctct ggccccttcc tctaagtcca caagcggtgg gaccgcagca      420

ctgggatgcc tggtgaagga ttacttccct gagccggtga ccgtgtcctg gaactccgga      480

gctctcacct ccggtgtcca tacctttcct gccgtcctgc agtcctccgg cctgtacagc      540

ctctctagcg tcgtgactgt gccctccagc tccctgggca cccaaactta tatctgcaat      600

gttaaccaca agccttctaa taccaaggtc gacaagaaag tggagccgaa gagctgtgac      660

aaaactcaca catgcccacc gtgcccagca cctccagtcg ccggaccgtc agtcttcctc      720

ttccctccaa aacccaagga caccctcatg atctcccgga cccctgaggt cacatgcgtg      780

gtggtggacg tgagccacga agaccctgag gtcaagttca actggtacgt ggacggcgtg      840

gaggtgcata atgccaagac aaagccgcgg gaggagcagt acaacagcac gtaccgtgtg      900

gtcagcgtcc tcaccgtcct gcaccaggac tggctgaatg gcaaggagta caagtgcaag      960

gtctccaaca aaggcctccc aagctccatc gagaaaacca tctccaaagc caaagggcag     1020

ccccgagaac cacaggtgta caccctgcct ccatcccggg atgagctgac caagaaccag     1080

gtcagcctga cctgcctggt caaaggcttc tatcccagcg acatcgccgt ggagtgggag     1140

agcaatgggc agccggagaa caactacaag accacgcctc ccgtgctgga ctccgacggc     1200

tccttcttcc tctacagcaa gctcaccgtg gacaagagca ggtggcagca ggggaacgtc     1260

ttctcatgct ccgtgatgca tgaggctctg cacaaccact acacgcagaa gagcctctcc     1320

ctgtctccgg gtaaataa                                                   1338


<210>  236
<211>  1362
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Made in Lab - antibody fragment

<400>  236
caggtacagc tgcagcagtc aggtccagga ctggtgaagc cctcgcagac cctctcactc       60

acctgtgcca tctccgggga cagtgtctct agcaacagtg ctgcttggaa ctggatcagg      120

cagtccccat cgagaggcct tgagtggctg ggaaggacat actacaggtc caagtggtat      180

aatgattatg cagtatctgt gaaaagtcga ataaccatca acccagacac atccaagaac      240

cagttctccc tgcagctgaa ctctgtgact cccgaggaca cggctgtgta ttactgtgca      300

agagaagtga ctggggatct cgaggatgct tttgatatct ggggccaagg gacaatggtc      360

accgtctcct cagcctccac caagggccca tcggtcttcc ccctggcacc ctcctccaag      420

agcacctctg ggggcacagc ggccctgggc tgcctggtca aggactactt ccccgaaccg      480

gtgacggtgt cgtggaactc aggcgccctg accagcggcg tgcacacctt cccggctgtc      540

ctacagtcct caggactcta ctccctcagc agcgtggtga ctgtgccctc tagcagcttg      600

ggcacccaga cctacatctg caacgtgaat cacaagccca gcaacaccaa ggtggacaag      660

aaagttgagc ccaaatcttg tgacaaaact cacacatgcc caccgtgccc agcacctcca      720

gtcgccggac cgtcagtctt cctcttccct ccaaaaccca aggacaccct catgatctcc      780

cggacccctg aggtcacatg cgtggtggtg gacgtgagcc acgaagaccc tgaggtcaag      840

ttcaactggt acgtggacgg cgtggaggtg cataatgcca agacaaagcc gcgggaggag      900

cagtacaaca gcacgtaccg tgtggtcagc gtcctcaccg tcctgcacca ggactggctg      960

aatggcaagg agtacaagtg caaggtctcc aacaaaggcc tcccaagctc catcgagaaa     1020

accatctcca aagccaaagg gcagccccga gaaccacagg tgtacaccct gcctccatcc     1080

cgggatgagc tgaccaagaa ccaggtcagc ctgacctgcc tggtcaaagg cttctatccc     1140

agcgacatcg ccgtggagtg ggagagcaat gggcagccgg agaacaacta caagaccacg     1200

cctcccgtgc tggactccga cggctccttc ttcctctaca gcaagctcac cgtggacaag     1260

agcaggtggc agcaggggaa cgtcttctca tgctccgtga tgcatgaggc tctgcacaac     1320

cactacacgc agaagagcct ctccctgtct ccgggtaaat aa                        1362


<210>  237
<211>  218
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - antibody fragment

<400>  237

Asp Ile Gln Leu Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Glu Ser Leu Asp Asn Tyr 
            20                  25                  30          


Gly Ile Arg Phe Leu Thr Trp Phe Gln Gln Lys Pro Gly Lys Ala Pro 
        35                  40                  45              


Lys Leu Leu Met Tyr Ala Ala Ser Asn Gln Gly Ser Gly Val Pro Ser 
    50                  55                  60                  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser 
65                  70                  75                  80  


Ser Leu Gln Pro Asp Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Thr Lys 
                85                  90                  95      


Glu Val Pro Trp Ser Phe Gly Gln Gly Thr Lys Val Glu Val Lys Arg 
            100                 105                 110         


Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln 
        115                 120                 125             


Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr 
    130                 135                 140                 


Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser 
145                 150                 155                 160 


Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr 
                165                 170                 175     


Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys 
            180                 185                 190         


His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro 
        195                 200                 205             


Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
    210                 215             


<210>  238
<211>  224
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - antibody fragment

<400>  238

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Ile Thr Asp Ser 
            20                  25                  30          


Asn Ile His Trp Val Arg Gln Ala Pro Gly Gln Ser Leu Glu Trp Ile 
        35                  40                  45              


Gly Tyr Ile Tyr Pro Tyr Asn Gly Gly Thr Asp Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Asn Arg Ala Thr Leu Thr Val Asp Asn Pro Thr Asn Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Phe Tyr Tyr Cys 
                85                  90                  95      


Val Asn Gly Asn Pro Trp Leu Ala Tyr Trp Gly Gln Gly Thr Leu Val 
            100                 105                 110         


Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala 
        115                 120                 125             


Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu 
    130                 135                 140                 


Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly 
145                 150                 155                 160 


Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser 
                165                 170                 175     


Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu 
            180                 185                 190         


Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr 
        195                 200                 205             


Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr 
    210                 215                 220                 


<210>  239
<211>  217
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - antibody fragment

<400>  239

Asp Ile Val Leu Thr Gln Ser Pro Ala Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Gln Arg Ala Thr Ile Ser Cys Arg Ala Ser Glu Ser Val Asp Asn Tyr 
            20                  25                  30          


Gly Asn Thr Phe Met His Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro 
        35                  40                  45              


Lys Leu Leu Ile Tyr Arg Ala Ser Asn Leu Glu Ser Gly Ile Pro Ala 
    50                  55                  60                  


Arg Phe Ser Gly Ser Gly Ser Arg Thr Asp Phe Thr Leu Thr Ile Asn 
65                  70                  75                  80  


Pro Val Glu Ala Asp Asp Val Ala Thr Tyr Tyr Cys Gln Gln Ser Asn 
                85                  90                  95      


Glu Asp Pro Pro Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Arg Thr 
            100                 105                 110         


Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu 
        115                 120                 125             


Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro 
    130                 135                 140                 


Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly 
145                 150                 155                 160 


Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr 
                165                 170                 175     


Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His 
            180                 185                 190         


Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val 
        195                 200                 205             


Thr Lys Ser Phe Asn Arg Gly Glu Cys 
    210                 215         


<210>  240
<211>  221
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - antibody fragment

<400>  240

Gln Ile Gln Leu Val Gln Ser Gly Pro Glu Leu Lys Lys Pro Gly Glu 
1               5                   10                  15      


Thr Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Ile Phe Thr Asn Tyr 
            20                  25                  30          


Gly Met Asn Trp Val Lys Gln Ala Pro Gly Lys Ser Phe Lys Trp Met 
        35                  40                  45              


Gly Trp Ile Asn Thr Tyr Thr Gly Glu Ser Thr Tyr Ser Ala Asp Phe 
    50                  55                  60                  


Lys Gly Arg Phe Ala Phe Ser Leu Glu Thr Ser Ala Ser Thr Ala Tyr 
65                  70                  75                  80  


Leu His Ile Asn Asp Leu Lys Asn Glu Asp Thr Ala Thr Tyr Phe Cys 
                85                  90                  95      


Ala Arg Ser Gly Gly Tyr Asp Pro Met Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Ser Val Thr Val Ser Ser Ala Arg Thr Lys Gly Pro Ser Val Phe Pro 
        115                 120                 125             


Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly 
    130                 135                 140                 


Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn 
145                 150                 155                 160 


Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln 
                165                 170                 175     


Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser 
            180                 185                 190         


Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser 
        195                 200                 205             


Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys 
    210                 215                 220     


<210>  241
<211>  213
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - antibody fragment

<400>  241

Asp Val Gln Ile Thr Gln Ser Pro Ser Tyr Leu Ala Ala Ser Pro Gly 
1               5                   10                  15      


Glu Thr Ile Thr Ile Asn Cys Arg Ala Ser Lys Ser Ile Ser Lys Asp 
            20                  25                  30          


Leu Ala Trp Tyr Gln Glu Lys Pro Gly Lys Thr Asn Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ser Gly Ser Thr Leu Gln Ser Gly Ile Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Met Tyr Tyr Cys Gln Gln His Asn Lys Tyr Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Arg Thr Val Ala Ala Pro 
            100                 105                 110         


Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly Thr 
        115                 120                 125             


Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala Lys 
    130                 135                 140                 


Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln Glu 
145                 150                 155                 160 


Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser Ser 
                165                 170                 175     


Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr Ala 
            180                 185                 190         


Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser Phe 
        195                 200                 205             


Asn Arg Gly Glu Cys 
    210             


<210>  242
<211>  218
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - antibody fragment

<400>  242

Gln Val Gln Leu Gln Gln Pro Gly Ala Glu Leu Val Arg Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Trp Met Asn Trp Val Lys Gln Arg Pro Asp Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Arg Ile Asp Pro Tyr Asp Ser Glu Thr His Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Asp Lys Ala Ile Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Asn Trp Asp Asp Tyr Trp Gly Gln Gly Thr Thr Leu Thr 
            100                 105                 110         


Val Ser Ser Ala Arg Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro 
        115                 120                 125             


Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val 
    130                 135                 140                 


Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala 
145                 150                 155                 160 


Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly 
                165                 170                 175     


Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly 
            180                 185                 190         


Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys 
        195                 200                 205             


Val Asp Lys Lys Val Glu Pro Lys Ser Cys 
    210                 215             


<210>  243
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - antibody fragment

<400>  243

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Lys Ala Ser Gln Asp Val Gly Ile Ala 
            20                  25                  30          


Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Val Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Trp Ala Ser Thr Arg His Thr Gly Val Pro Asp Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Val Ala Thr Tyr Tyr Cys Gln Gln Tyr Ser Ser Tyr Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  244
<211>  222
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - antibody fragment

<400>  244

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Asp Phe Ser Arg Tyr 
            20                  25                  30          


Trp Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Glu Ile Asn Pro Asp Ser Ser Thr Ile Asn Tyr Ala Pro Ser Leu 
    50                  55                  60                  


Lys Asp Lys Phe Ile Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Pro Asp Gly Asn Tyr Trp Tyr Phe Asp Val Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe 
        115                 120                 125             


Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu 
    130                 135                 140                 


Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp 
145                 150                 155                 160 


Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu 
                165                 170                 175     


Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser 
            180                 185                 190         


Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro 
        195                 200                 205             


Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys 
    210                 215                 220         


<210>  245
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - antibody fragment

<400>  245

Asn Tyr His Leu Glu Asn Glu Val Ala Arg Leu Lys Lys 
1               5                   10              


<210>  246
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - antibody fragment

<400>  246

Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly 
            20  


<210>  247
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - antibody fragment

<400>  247

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Lys Ala Ser Gln Asp Val Gly Ile Ala 
            20                  25                  30          


Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Val Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Trp Ala Ser Thr Arg His Thr Gly Val Pro Asp Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Val Ala Thr Tyr Tyr Cys Gln Gln Tyr Ser Ser Tyr Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  248
<211>  119
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - antibody fragment

<400>  248

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Asp Phe Ser Arg Tyr 
            20                  25                  30          


Trp Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Glu Ile Asn Pro Asp Ser Ser Thr Ile Asn Tyr Ala Pro Ser Leu 
    50                  55                  60                  


Lys Asp Lys Phe Ile Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Pro Asp Gly Asn Tyr Trp Tyr Phe Asp Val Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210>  249
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - antibody fragment

<400>  249

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Val Asn Thr Ala 
            20                  25                  30          


Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ser Ala Ser Phe Leu Tyr Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Arg Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln His Tyr Thr Thr Pro Pro 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  250
<211>  114
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - antibody fragment

<400>  250

Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gln Thr Leu 
1               5                   10                  15      


Ser Leu Thr Cys Thr Val Ser Gly Tyr Ser Ile Ser Ser Asp Phe Ala 
            20                  25                  30          


Trp Asn Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Met Gly 
        35                  40                  45              


Tyr Ile Ser Tyr Ser Gly Asn Thr Arg Tyr Gln Pro Ser Leu Lys Ser 
    50                  55                  60                  


Arg Ile Thr Ile Ser Arg Asp Thr Ser Lys Asn Gln Phe Phe Leu Lys 
65                  70                  75                  80  


Leu Asn Ser Val Thr Ala Ala Asp Thr Ala Thr Tyr Tyr Cys Val Thr 
                85                  90                  95      


Ala Gly Arg Gly Phe Pro Tyr Trp Gly Gln Gly Thr Leu Val Thr Val 
            100                 105                 110         


Ser Ser 
        


<210>  251
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - antibody fragment

<400>  251

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Asn Gln Gly Ile Ser Asn Asn 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Pro Leu Ile 
        35                  40                  45              


Tyr Tyr Thr Ser Asn Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Tyr Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Phe Thr Ser Leu Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  252
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - antibody fragment

<400>  252

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Phe 
            20                  25                  30          


Asp Met Ala Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Val Trp Val 
        35                  40                  45              


Ser Ser Ile Thr Thr Gly Gly Gly Asp Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Ser Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asp Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Val Arg His Gly Tyr Tyr Asp Gly Tyr His Leu Phe Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120     


<210>  253
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - antibody fragment

<400>  253

Asp Ile Gln Met Thr Gln Thr Thr Ser Ser Leu Ser Ala Ser Leu Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Ser Cys Arg Ala Ser Gln Asp Ile Ser Lys Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Asp Gly Thr Val Lys Leu Leu Ile 
        35                  40                  45              


Tyr His Thr Ser Arg Leu His Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Tyr Ser Leu Thr Ile Ser Asn Leu Glu Gln 
65                  70                  75                  80  


Glu Asp Ile Ala Thr Tyr Phe Cys Gln Gln Gly Asn Thr Leu Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  254
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - antibody fragment

<400>  254

Glu Val Lys Leu Gln Glu Ser Gly Pro Gly Leu Val Ala Pro Ser Gln 
1               5                   10                  15      


Ser Leu Ser Val Thr Cys Thr Val Ser Gly Val Ser Leu Pro Asp Tyr 
            20                  25                  30          


Gly Val Ser Trp Ile Arg Gln Pro Pro Arg Lys Gly Leu Glu Trp Leu 
        35                  40                  45              


Gly Val Ile Trp Gly Ser Glu Thr Thr Tyr Tyr Asn Ser Ala Leu Lys 
    50                  55                  60                  


Ser Arg Leu Thr Ile Ile Lys Asp Asn Ser Lys Ser Gln Val Phe Leu 
65                  70                  75                  80  


Lys Met Asn Ser Leu Gln Thr Asp Asp Thr Ala Ile Tyr Tyr Cys Ala 
                85                  90                  95      


Lys His Tyr Tyr Tyr Gly Gly Ser Tyr Ala Met Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Ser Val Thr Val Ser Ser 
        115                 120 


<210>  255
<211>  108
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - antibody fragment

<400>  255

Glu Asn Val Leu Thr Gln Ser Pro Ala Ile Met Ser Ala Ser Pro Gly 
1               5                   10                  15      


Glu Lys Val Thr Met Thr Cys Arg Ala Ser Ser Asn Val Ile Ser Ser 
            20                  25                  30          


Tyr Val His Trp Tyr Gln Gln Arg Ser Gly Ala Ser Pro Lys Leu Trp 
        35                  40                  45              


Ile Tyr Ser Thr Ser Asn Leu Ala Ser Gly Val Pro Ala Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Ser Val Glu 
65                  70                  75                  80  


Ala Glu Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Tyr Ser Gly Tyr Pro 
                85                  90                  95      


Leu Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys 
            100                 105             


<210>  256
<211>  123
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - antibody fragment

<400>  256

Asp Ile Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gln 
1               5                   10                  15      


Ser Leu Ser Leu Thr Cys Ser Val Thr Gly Tyr Ser Ile Thr Ser Ala 
            20                  25                  30          


Tyr Tyr Trp Asn Trp Ile Arg Gln Phe Pro Gly Asn Lys Leu Glu Trp 
        35                  40                  45              


Met Gly Tyr Ile Ser Tyr Asp Gly Arg Asn Asn Tyr Asn Pro Ser Leu 
    50                  55                  60                  


Lys Asn Arg Ile Ser Ile Thr Arg Asp Thr Ser Lys Asn Gln Phe Phe 
65                  70                  75                  80  


Leu Lys Leu Asn Ser Val Thr Thr Glu Asp Thr Ala Thr Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Glu Gly Asp Tyr Asp Val Gly Asn Tyr Tyr Ala Met Asp Tyr 
            100                 105                 110         


Trp Gly Gln Gly Thr Ser Val Thr Val Ser Ser 
        115                 120             


<210>  257
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - antibody fragment

<400>  257

Asp Ile Gln Leu Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Glu Ser Leu Asp Asn Tyr 
            20                  25                  30          


Gly Ile Arg Phe Leu Thr Trp Phe Gln Gln Lys Pro Gly Lys Ala Pro 
        35                  40                  45              


Lys Leu Leu Met Tyr Ala Ala Ser Asn Gln Gly Ser Gly Val Pro Ser 
    50                  55                  60                  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser 
65                  70                  75                  80  


Ser Leu Gln Pro Asp Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Thr Lys 
                85                  90                  95      


Glu Val Pro Trp Ser Phe Gly Gln Gly Thr Lys Val Glu Val Lys 
            100                 105                 110     


<210>  258
<211>  116
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - antibody fragment

<400>  258

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Ile Thr Asp Ser 
            20                  25                  30          


Asn Ile His Trp Val Arg Gln Ala Pro Gly Gln Ser Leu Glu Trp Ile 
        35                  40                  45              


Gly Tyr Ile Tyr Pro Tyr Asn Gly Gly Thr Asp Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Asn Arg Ala Thr Leu Thr Val Asp Asn Pro Thr Asn Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Phe Tyr Tyr Cys 
                85                  90                  95      


Val Asn Gly Asn Pro Trp Leu Ala Tyr Trp Gly Gln Gly Thr Leu Val 
            100                 105                 110         


Thr Val Ser Ser 
        115     


<210>  259
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - antibody fragment

<400>  259

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Glu Ser Val Asp Asn Tyr 
            20                  25                  30          


Gly Ile Ser Phe Met Asn Trp Phe Gln Gln Lys Pro Gly Lys Ala Pro 
        35                  40                  45              


Lys Leu Leu Ile Tyr Ala Ala Ser Asn Gln Gly Ser Gly Val Pro Ser 
    50                  55                  60                  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Asn Ile Ser 
65                  70                  75                  80  


Ser Leu Gln Pro Asp Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Lys 
                85                  90                  95      


Glu Val Pro Trp Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105                 110     


<210>  260
<211>  116
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - antibody fragment

<400>  260

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Tyr 
            20                  25                  30          


Asn Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Tyr Ile Tyr Pro Tyr Asn Gly Gly Thr Gly Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Ser Lys Ala Thr Ile Thr Ala Asp Glu Ser Thr Asn Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Arg Pro Ala Met Asp Tyr Trp Gly Gln Gly Thr Leu Val 
            100                 105                 110         


Thr Val Ser Ser 
        115     


<210>  261
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - antibody fragment

<400>  261

Asp Ile Val Leu Thr Gln Ser Pro Ala Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Gln Arg Ala Thr Ile Ser Cys Arg Ala Ser Glu Ser Val Asp Asn Tyr 
            20                  25                  30          


Gly Asn Thr Phe Met His Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro 
        35                  40                  45              


Lys Leu Leu Ile Tyr Arg Ala Ser Asn Leu Glu Ser Gly Ile Pro Ala 
    50                  55                  60                  


Arg Phe Ser Gly Ser Gly Ser Arg Thr Asp Phe Thr Leu Thr Ile Asn 
65                  70                  75                  80  


Pro Val Glu Ala Asp Asp Val Ala Thr Tyr Tyr Cys Gln Gln Ser Asn 
                85                  90                  95      


Glu Asp Pro Pro Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys 
            100                 105                 110     


<210>  262
<211>  118
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - antibody fragment

<400>  262

Gln Ile Gln Leu Val Gln Ser Gly Pro Glu Leu Lys Lys Pro Gly Glu 
1               5                   10                  15      


Thr Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Ile Phe Thr Asn Tyr 
            20                  25                  30          


Gly Met Asn Trp Val Lys Gln Ala Pro Gly Lys Ser Phe Lys Trp Met 
        35                  40                  45              


Gly Trp Ile Asn Thr Tyr Thr Gly Glu Ser Thr Tyr Ser Ala Asp Phe 
    50                  55                  60                  


Lys Gly Arg Phe Ala Phe Ser Leu Glu Thr Ser Ala Ser Thr Ala Tyr 
65                  70                  75                  80  


Leu His Ile Asn Asp Leu Lys Asn Glu Asp Thr Ala Thr Tyr Phe Cys 
                85                  90                  95      


Ala Arg Ser Gly Gly Tyr Asp Pro Met Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Ser Val Thr Val Ser Ser 
        115             


<210>  263
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - antibody fragment

<400>  263

Asp Val Gln Ile Thr Gln Ser Pro Ser Tyr Leu Ala Ala Ser Pro Gly 
1               5                   10                  15      


Glu Thr Ile Thr Ile Asn Cys Arg Ala Ser Lys Ser Ile Ser Lys Asp 
            20                  25                  30          


Leu Ala Trp Tyr Gln Glu Lys Pro Gly Lys Thr Asn Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ser Gly Ser Thr Leu Gln Ser Gly Ile Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Met Tyr Tyr Cys Gln Gln His Asn Lys Tyr Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  264
<211>  115
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - antibody fragment

<400>  264

Gln Val Gln Leu Gln Gln Pro Gly Ala Glu Leu Val Arg Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Trp Met Asn Trp Val Lys Gln Arg Pro Asp Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Arg Ile Asp Pro Tyr Asp Ser Glu Thr His Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Asp Lys Ala Ile Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Asn Trp Asp Asp Tyr Trp Gly Gln Gly Thr Thr Leu Thr 
            100                 105                 110         


Val Ser Ser 
        115 


<210>  265
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - antibody fragment

<400>  265

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Thr Ile Trp Ser Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Arg Pro Gly Lys Ala Pro Asn Leu Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Arg Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Ala 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Tyr Ser Ile Pro Gln 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  266
<211>  124
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - antibody fragment

<400>  266

Gln Val Gln Leu Gln Gln Ser Gly Pro Gly Leu Val Lys Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Ala Ile Ser Gly Asp Ser Val Ser Ser Asn 
            20                  25                  30          


Ser Ala Ala Trp Asn Trp Ile Arg Gln Ser Pro Ser Arg Gly Leu Glu 
        35                  40                  45              


Trp Leu Gly Arg Thr Tyr Tyr Arg Ser Lys Trp Tyr Asn Asp Tyr Ala 
    50                  55                  60                  


Val Ser Val Lys Ser Arg Ile Thr Ile Asn Pro Asp Thr Ser Lys Asn 
65                  70                  75                  80  


Gln Phe Ser Leu Gln Leu Asn Ser Val Thr Pro Glu Asp Thr Ala Val 
                85                  90                  95      


Tyr Tyr Cys Ala Arg Glu Val Thr Gly Asp Leu Glu Asp Ala Phe Asp 
            100                 105                 110         


Ile Trp Gly Gln Gly Thr Met Val Thr Val Ser Ser 
        115                 120                 


<210>  267
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - antibody fragment

<400>  267

Asp Ile Gln Leu Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Met Ser Cys Lys Ser Ser Gln Ser Val Leu Tyr Ser 
            20                  25                  30          


Ala Asn His Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys 
        35                  40                  45              


Ala Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Phe Thr 
65                  70                  75                  80  


Ile Ser Ser Leu Gln Pro Glu Asp Ile Ala Thr Tyr Tyr Cys His Gln 
                85                  90                  95      


Tyr Leu Ser Ser Trp Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


<210>  268
<211>  116
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - antibody fragment

<400>  268

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Trp Leu His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Tyr Ile Asn Pro Arg Asn Asp Tyr Thr Glu Tyr Asn Gln Asn Phe 
    50                  55                  60                  


Lys Asp Lys Ala Thr Ile Thr Ala Asp Glu Ser Thr Asn Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Phe Tyr Phe Cys 
                85                  90                  95      


Ala Arg Arg Asp Ile Thr Thr Phe Tyr Trp Gly Gln Gly Thr Thr Val 
            100                 105                 110         


Thr Val Ser Ser 
        115     


<210>  269
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Motif of GNC4 peptide derivatives


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Any amino acid or absent

<220>
<221>  MOD_RES
<222>  (14)..(15)
<223>  Any amino acid or absent

<400>  269

Xaa Asn Tyr His Leu Glu Asn Glu Val Ala Arg Leu Lys Xaa Xaa 
1               5                   10                  15  


<210>  270
<211>  475
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - CAR construct

<400>  270

Met Gly Val Pro Thr Gln Leu Leu Gly Leu Leu Leu Leu Trp Ile Thr 
1               5                   10                  15      


Asp Ala Ile Cys Asp Ile Gln Met Thr Gln Ser Pro Ala Ser Leu Ser 
            20                  25                  30          


Thr Ser Leu Gly Glu Thr Val Thr Ile Gln Cys Gln Ala Ser Glu Asp 
        35                  40                  45              


Ile Tyr Ser Gly Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ser Pro 
    50                  55                  60                  


Gln Leu Leu Ile Tyr Gly Ala Ser Asp Leu Gln Asp Gly Val Pro Ser 
65                  70                  75                  80  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Gln Tyr Ser Leu Lys Ile Thr 
                85                  90                  95      


Ser Met Gln Thr Glu Asp Glu Gly Val Tyr Phe Cys Gln Gln Gly Leu 
            100                 105                 110         


Thr Tyr Pro Arg Thr Phe Gly Gly Gly Thr Lys Leu Glu Leu Lys Gly 
        115                 120                 125             


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val 
    130                 135                 140                 


Gln Leu Gln Gln Ser Gly Ala Glu Leu Val Arg Pro Gly Thr Ser Val 
145                 150                 155                 160 


Lys Leu Ser Cys Lys Val Ser Gly Asp Thr Ile Thr Phe Tyr Tyr Met 
                165                 170                 175     


His Phe Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile Gly Arg 
            180                 185                 190         


Ile Asp Pro Glu Asp Glu Ser Thr Lys Tyr Ser Glu Lys Phe Lys Asn 
        195                 200                 205             


Lys Ala Thr Leu Thr Ala Asp Thr Ser Ser Asn Thr Ala Tyr Leu Lys 
    210                 215                 220                 


Leu Ser Ser Leu Thr Ser Glu Asp Thr Ala Thr Tyr Phe Cys Ile Tyr 
225                 230                 235                 240 


Gly Gly Tyr Tyr Phe Asp Tyr Trp Gly Gln Gly Val Met Val Thr Val 
                245                 250                 255     


Ser Ser Ile Glu Phe Met Tyr Pro Pro Pro Tyr Leu Asp Asn Glu Arg 
            260                 265                 270         


Ser Asn Gly Thr Ile Ile His Ile Lys Glu Lys His Leu Cys His Thr 
        275                 280                 285             


Gln Ser Ser Pro Lys Leu Phe Trp Ala Leu Val Val Val Ala Gly Val 
    290                 295                 300                 


Leu Phe Cys Tyr Gly Leu Leu Val Thr Val Ala Leu Cys Val Ile Trp 
305                 310                 315                 320 


Thr Asn Ser Arg Arg Asn Arg Gly Gly Gln Ser Asp Tyr Met Asn Met 
                325                 330                 335     


Thr Pro Arg Arg Pro Gly Leu Thr Arg Lys Pro Tyr Gln Pro Tyr Ala 
            340                 345                 350         


Pro Ala Arg Asp Phe Ala Ala Tyr Arg Pro Arg Ala Lys Phe Ser Arg 
        355                 360                 365             


Ser Ala Glu Thr Ala Ala Asn Leu Gln Asp Pro Asn Gln Leu Phe Asn 
    370                 375                 380                 


Glu Leu Asn Leu Gly Arg Arg Glu Glu Phe Asp Val Leu Glu Lys Lys 
385                 390                 395                 400 


Arg Ala Arg Asp Pro Glu Met Gly Gly Lys Gln Gln Arg Arg Arg Asn 
                405                 410                 415     


Pro Gln Glu Gly Val Tyr Asn Ala Leu Gln Lys Asp Lys Met Ala Glu 
            420                 425                 430         


Ala Tyr Ser Glu Ile Gly Thr Lys Gly Glu Arg Arg Arg Gly Lys Gly 
        435                 440                 445             


His Asp Gly Leu Phe Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Phe 
    450                 455                 460                 


Asp Ala Leu His Met Gln Thr Leu Ala Pro Arg 
465                 470                 475 


<210>  271
<211>  460
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - CAR construct

<400>  271

Asp Ala Val Val Thr Gln Glu Ser Ala Leu Thr Ser Ser Pro Gly Glu 
1               5                   10                  15      


Thr Val Thr Leu Thr Cys Arg Ser Ser Thr Gly Ala Val Thr Thr Ser 
            20                  25                  30          


Asn Tyr Ala Ser Trp Val Gln Glu Lys Pro Asp His Leu Phe Thr Gly 
        35                  40                  45              


Leu Ile Gly Gly Thr Asn Asn Arg Ala Pro Gly Val Pro Ala Arg Phe 
    50                  55                  60                  


Ser Gly Ser Leu Ile Gly Asp Lys Ala Ala Leu Thr Ile Thr Gly Ala 
65                  70                  75                  80  


Gln Thr Glu Asp Glu Ala Ile Tyr Phe Cys Val Leu Trp Tyr Ser Asp 
                85                  90                  95      


His Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Gly Gly 
            100                 105                 110         


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Asp Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Ala Pro 
    130                 135                 140                 


Ser Gln Ser Leu Ser Ile Thr Cys Thr Val Ser Gly Phe Leu Leu Thr 
145                 150                 155                 160 


Asp Tyr Gly Val Asn Trp Val Arg Gln Ser Pro Gly Lys Gly Leu Glu 
                165                 170                 175     


Trp Leu Gly Val Ile Trp Gly Asp Gly Ile Thr Asp Tyr Asn Ser Ala 
            180                 185                 190         


Leu Lys Ser Arg Leu Ser Val Thr Lys Asp Asn Ser Lys Ser Gln Val 
        195                 200                 205             


Phe Leu Lys Met Asn Ser Leu Gln Ser Gly Asp Ser Ala Arg Tyr Tyr 
    210                 215                 220                 


Cys Val Thr Gly Leu Phe Asp Tyr Trp Gly Gln Gly Thr Thr Leu Thr 
225                 230                 235                 240 


Val Ser Ser Ile Glu Phe Met Tyr Pro Pro Pro Tyr Leu Asp Asn Glu 
                245                 250                 255     


Arg Ser Asn Gly Thr Ile Ile His Ile Lys Glu Lys His Leu Cys His 
            260                 265                 270         


Thr Gln Ser Ser Pro Lys Leu Phe Trp Ala Leu Val Val Val Ala Gly 
        275                 280                 285             


Val Leu Phe Cys Tyr Gly Leu Leu Val Thr Val Ala Leu Cys Val Ile 
    290                 295                 300                 


Trp Thr Asn Ser Arg Arg Asn Arg Gly Gly Gln Ser Asp Tyr Met Asn 
305                 310                 315                 320 


Met Thr Pro Arg Arg Pro Gly Leu Thr Arg Lys Pro Tyr Gln Pro Tyr 
                325                 330                 335     


Ala Pro Ala Arg Asp Phe Ala Ala Tyr Arg Pro Arg Ala Lys Phe Ser 
            340                 345                 350         


Arg Ser Ala Glu Thr Ala Ala Asn Leu Gln Asp Pro Asn Gln Leu Phe 
        355                 360                 365             


Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Phe Asp Val Leu Glu Lys 
    370                 375                 380                 


Lys Arg Ala Arg Asp Pro Glu Met Gly Gly Lys Gln Gln Arg Arg Arg 
385                 390                 395                 400 


Asn Pro Gln Glu Gly Val Tyr Asn Ala Leu Gln Lys Asp Lys Met Ala 
                405                 410                 415     


Glu Ala Tyr Ser Glu Ile Gly Thr Lys Gly Glu Arg Arg Arg Gly Lys 
            420                 425                 430         


Gly His Asp Gly Leu Phe Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr 
        435                 440                 445             


Phe Asp Ala Leu His Met Gln Thr Leu Ala Pro Arg 
    450                 455                 460 


<210>  272
<211>  436
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - CAR construct

<400>  272

Asp Ala Val Val Thr Gln Glu Ser Ala Leu Thr Ser Ser Pro Gly Glu 
1               5                   10                  15      


Thr Val Thr Leu Thr Cys Arg Ser Ser Thr Gly Ala Val Thr Thr Ser 
            20                  25                  30          


Asn Tyr Ala Ser Trp Val Gln Glu Lys Pro Asp His Leu Phe Thr Gly 
        35                  40                  45              


Leu Ile Gly Gly Thr Asn Asn Arg Ala Pro Gly Val Pro Ala Arg Phe 
    50                  55                  60                  


Ser Gly Ser Leu Ile Gly Asp Lys Ala Ala Leu Thr Ile Thr Gly Ala 
65                  70                  75                  80  


Gln Thr Glu Asp Glu Ala Ile Tyr Phe Cys Val Leu Trp Tyr Ser Asp 
                85                  90                  95      


His Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Gly Gly 
            100                 105                 110         


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Asp Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Ala Pro 
    130                 135                 140                 


Ser Gln Ser Leu Ser Ile Thr Cys Thr Val Ser Gly Phe Leu Leu Thr 
145                 150                 155                 160 


Asp Tyr Gly Val Asn Trp Val Arg Gln Ser Pro Gly Lys Gly Leu Glu 
                165                 170                 175     


Trp Leu Gly Val Ile Trp Gly Asp Gly Ile Thr Asp Tyr Asn Ser Ala 
            180                 185                 190         


Leu Lys Ser Arg Leu Ser Val Thr Lys Asp Asn Ser Lys Ser Gln Val 
        195                 200                 205             


Phe Leu Lys Met Asn Ser Leu Gln Ser Gly Asp Ser Ala Arg Tyr Tyr 
    210                 215                 220                 


Cys Val Thr Gly Leu Phe Asp Tyr Trp Gly Gln Gly Thr Thr Leu Thr 
225                 230                 235                 240 


Val Ser Ser Glu Ser Lys Tyr Gly Pro Pro Cys Pro Pro Cys Pro Phe 
                245                 250                 255     


Trp Ala Leu Val Val Val Ala Gly Val Leu Phe Cys Tyr Gly Leu Leu 
            260                 265                 270         


Val Thr Val Ala Leu Cys Val Ile Trp Thr Asn Ser Arg Arg Asn Arg 
        275                 280                 285             


Gly Gly Gln Ser Asp Tyr Met Asn Met Thr Pro Arg Arg Pro Gly Leu 
    290                 295                 300                 


Thr Arg Lys Pro Tyr Gln Pro Tyr Ala Pro Ala Arg Asp Phe Ala Ala 
305                 310                 315                 320 


Tyr Arg Pro Arg Ala Lys Phe Ser Arg Ser Ala Glu Thr Ala Ala Asn 
                325                 330                 335     


Leu Gln Asp Pro Asn Gln Leu Phe Asn Glu Leu Asn Leu Gly Arg Arg 
            340                 345                 350         


Glu Glu Phe Asp Val Leu Glu Lys Lys Arg Ala Arg Asp Pro Glu Met 
        355                 360                 365             


Gly Gly Lys Gln Gln Arg Arg Arg Asn Pro Gln Glu Gly Val Tyr Asn 
    370                 375                 380                 


Ala Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Thr 
385                 390                 395                 400 


Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Phe Gln Gly 
                405                 410                 415     


Leu Ser Thr Ala Thr Lys Asp Thr Phe Asp Ala Leu His Met Gln Thr 
            420                 425                 430         


Leu Ala Pro Arg 
        435     


<210>  273
<211>  440
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - CAR construct

<400>  273

Asp Ala Val Val Thr Gln Glu Ser Ala Leu Thr Ser Ser Pro Gly Glu 
1               5                   10                  15      


Thr Val Thr Leu Thr Cys Arg Ser Ser Thr Gly Ala Val Thr Thr Ser 
            20                  25                  30          


Asn Tyr Ala Ser Trp Val Gln Glu Lys Pro Asp His Leu Phe Thr Gly 
        35                  40                  45              


Leu Ile Gly Gly Thr Asn Asn Arg Ala Pro Gly Val Pro Ala Arg Phe 
    50                  55                  60                  


Ser Gly Ser Leu Ile Gly Asp Lys Ala Ala Leu Thr Ile Thr Gly Ala 
65                  70                  75                  80  


Gln Thr Glu Asp Glu Ala Ile Tyr Phe Cys Val Leu Trp Tyr Ser Asp 
                85                  90                  95      


His Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Gly Gly 
            100                 105                 110         


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Asp Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Ala Pro 
    130                 135                 140                 


Ser Gln Ser Leu Ser Ile Thr Cys Thr Val Ser Gly Phe Leu Leu Thr 
145                 150                 155                 160 


Asp Tyr Gly Val Asn Trp Val Arg Gln Ser Pro Gly Lys Gly Leu Glu 
                165                 170                 175     


Trp Leu Gly Val Ile Trp Gly Asp Gly Ile Thr Asp Tyr Asn Ser Ala 
            180                 185                 190         


Leu Lys Ser Arg Leu Ser Val Thr Lys Asp Asn Ser Lys Ser Gln Val 
        195                 200                 205             


Phe Leu Lys Met Asn Ser Leu Gln Ser Gly Asp Ser Ala Arg Tyr Tyr 
    210                 215                 220                 


Cys Val Thr Gly Leu Phe Asp Tyr Trp Gly Gln Gly Thr Thr Leu Thr 
225                 230                 235                 240 


Val Ser Ser Glu Ser Lys Tyr Gly Pro Pro Cys Pro Pro Cys Pro Phe 
                245                 250                 255     


Trp Ala Leu Val Val Val Ala Gly Val Leu Phe Cys Tyr Gly Leu Leu 
            260                 265                 270         


Val Thr Val Ala Leu Cys Val Ile Trp Thr Lys Trp Ile Arg Lys Lys 
        275                 280                 285             


Phe Pro His Ile Phe Lys Gln Pro Phe Lys Lys Thr Thr Gly Ala Ala 
    290                 295                 300                 


Gln Glu Glu Asp Ala Cys Ser Cys Arg Cys Pro Gln Glu Glu Glu Gly 
305                 310                 315                 320 


Gly Gly Gly Gly Tyr Glu Leu Arg Ala Lys Phe Ser Arg Ser Ala Glu 
                325                 330                 335     


Thr Ala Ala Asn Leu Gln Asp Pro Asn Gln Leu Phe Asn Glu Leu Asn 
            340                 345                 350         


Leu Gly Arg Arg Glu Glu Phe Asp Val Leu Glu Lys Lys Arg Ala Arg 
        355                 360                 365             


Asp Pro Glu Met Gly Gly Lys Gln Gln Arg Arg Arg Asn Pro Gln Glu 
    370                 375                 380                 


Gly Val Tyr Asn Ala Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser 
385                 390                 395                 400 


Glu Ile Gly Thr Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly 
                405                 410                 415     


Leu Phe Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Phe Asp Ala Leu 
            420                 425                 430         


His Met Gln Thr Leu Ala Pro Arg 
        435                 440 


<210>  274
<211>  481
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - CAR construct

<400>  274

Asp Ala Val Val Thr Gln Glu Ser Ala Leu Thr Ser Ser Pro Gly Glu 
1               5                   10                  15      


Thr Val Thr Leu Thr Cys Arg Ser Ser Thr Gly Ala Val Thr Thr Ser 
            20                  25                  30          


Asn Tyr Ala Ser Trp Val Gln Glu Lys Pro Asp His Leu Phe Thr Gly 
        35                  40                  45              


Leu Ile Gly Gly Thr Asn Asn Arg Ala Pro Gly Val Pro Ala Arg Phe 
    50                  55                  60                  


Ser Gly Ser Leu Ile Gly Asp Lys Ala Ala Leu Thr Ile Thr Gly Ala 
65                  70                  75                  80  


Gln Thr Glu Asp Glu Ala Ile Tyr Phe Cys Val Leu Trp Tyr Ser Asp 
                85                  90                  95      


His Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Gly Gly 
            100                 105                 110         


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Asp Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Ala Pro 
    130                 135                 140                 


Ser Gln Ser Leu Ser Ile Thr Cys Thr Val Ser Gly Phe Leu Leu Thr 
145                 150                 155                 160 


Asp Tyr Gly Val Asn Trp Val Arg Gln Ser Pro Gly Lys Gly Leu Glu 
                165                 170                 175     


Trp Leu Gly Val Ile Trp Gly Asp Gly Ile Thr Asp Tyr Asn Ser Ala 
            180                 185                 190         


Leu Lys Ser Arg Leu Ser Val Thr Lys Asp Asn Ser Lys Ser Gln Val 
        195                 200                 205             


Phe Leu Lys Met Asn Ser Leu Gln Ser Gly Asp Ser Ala Arg Tyr Tyr 
    210                 215                 220                 


Cys Val Thr Gly Leu Phe Asp Tyr Trp Gly Gln Gly Thr Thr Leu Thr 
225                 230                 235                 240 


Val Ser Ser Glu Ser Lys Tyr Gly Pro Pro Cys Pro Pro Cys Pro Phe 
                245                 250                 255     


Trp Ala Leu Val Val Val Ala Gly Val Leu Phe Cys Tyr Gly Leu Leu 
            260                 265                 270         


Val Thr Val Ala Leu Cys Val Ile Trp Thr Asn Ser Arg Arg Asn Arg 
        275                 280                 285             


Gly Gly Gln Ser Asp Tyr Met Asn Met Thr Pro Arg Arg Pro Gly Leu 
    290                 295                 300                 


Thr Arg Lys Pro Tyr Gln Pro Tyr Ala Pro Ala Arg Asp Phe Ala Ala 
305                 310                 315                 320 


Tyr Arg Pro Lys Trp Ile Arg Lys Lys Phe Pro His Ile Phe Lys Gln 
                325                 330                 335     


Pro Phe Lys Lys Thr Thr Gly Ala Ala Gln Glu Glu Asp Ala Cys Ser 
            340                 345                 350         


Cys Arg Cys Pro Gln Glu Glu Glu Gly Gly Gly Gly Gly Tyr Glu Leu 
        355                 360                 365             


Arg Ala Lys Phe Ser Arg Ser Ala Glu Thr Ala Ala Asn Leu Gln Asp 
    370                 375                 380                 


Pro Asn Gln Leu Phe Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Phe 
385                 390                 395                 400 


Asp Val Leu Glu Lys Lys Arg Ala Arg Asp Pro Glu Met Gly Gly Lys 
                405                 410                 415     


Gln Gln Arg Arg Arg Asn Pro Gln Glu Gly Val Tyr Asn Ala Leu Gln 
            420                 425                 430         


Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Thr Lys Gly Glu 
        435                 440                 445             


Arg Arg Arg Gly Lys Gly His Asp Gly Leu Phe Gln Gly Leu Ser Thr 
    450                 455                 460                 


Ala Thr Lys Asp Thr Phe Asp Ala Leu His Met Gln Thr Leu Ala Pro 
465                 470                 475                 480 


Arg 
    


<210>  275
<211>  436
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - CAR construct

<400>  275

Asp Ala Val Val Thr Gln Glu Ser Ala Leu Thr Ser Ser Pro Gly Glu 
1               5                   10                  15      


Thr Val Thr Leu Thr Cys Arg Ser Ser Thr Gly Ala Val Thr Thr Ser 
            20                  25                  30          


Asn Tyr Ala Ser Trp Val Gln Glu Lys Pro Asp His Leu Phe Thr Gly 
        35                  40                  45              


Leu Ile Gly Gly Thr Asn Asn Arg Ala Pro Gly Val Pro Ala Arg Phe 
    50                  55                  60                  


Ser Gly Ser Leu Ile Gly Asp Lys Ala Ala Leu Thr Ile Thr Gly Ala 
65                  70                  75                  80  


Gln Thr Glu Asp Glu Ala Ile Tyr Phe Cys Val Leu Trp Tyr Ser Asp 
                85                  90                  95      


His Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Gly Gly 
            100                 105                 110         


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Asp Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Ala Pro 
    130                 135                 140                 


Ser Gln Ser Leu Ser Ile Thr Cys Thr Val Ser Gly Phe Leu Leu Thr 
145                 150                 155                 160 


Asp Tyr Gly Val Asn Trp Val Arg Gln Ser Pro Gly Lys Gly Leu Glu 
                165                 170                 175     


Trp Leu Gly Val Ile Trp Gly Asp Gly Ile Thr Asp Tyr Asn Ser Ala 
            180                 185                 190         


Leu Lys Ser Arg Leu Ser Val Thr Lys Asp Asn Ser Lys Ser Gln Val 
        195                 200                 205             


Phe Leu Lys Met Asn Ser Leu Gln Ser Gly Asp Ser Ala Arg Tyr Tyr 
    210                 215                 220                 


Cys Val Thr Gly Leu Phe Asp Tyr Trp Gly Gln Gly Thr Thr Leu Thr 
225                 230                 235                 240 


Val Ser Ser Glu Ser Lys Tyr Gly Pro Pro Cys Pro Pro Cys Pro Phe 
                245                 250                 255     


Trp Ala Leu Val Val Val Ala Gly Val Leu Phe Cys Tyr Gly Leu Leu 
            260                 265                 270         


Val Thr Val Ala Leu Cys Val Ile Trp Thr Asn Ser Arg Arg Asn Arg 
        275                 280                 285             


Gly Gly Gln Ser Asp Tyr Met Asn Met Thr Pro Arg Arg Pro Gly Leu 
    290                 295                 300                 


Thr Arg Lys Pro Tyr Gln Pro Tyr Ala Pro Ala Arg Asp Phe Ala Ala 
305                 310                 315                 320 


Tyr Arg Pro Arg Ala Lys Phe Ser Arg Ser Ala Glu Thr Ala Ala Asn 
                325                 330                 335     


Leu Gln Asp Pro Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg 
            340                 345                 350         


Glu Glu Tyr Asp Val Leu Glu Lys Lys Arg Ala Arg Asp Pro Glu Met 
        355                 360                 365             


Gly Gly Lys Gln Gln Arg Arg Arg Asn Pro Gln Glu Gly Val Tyr Asn 
    370                 375                 380                 


Ala Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Thr 
385                 390                 395                 400 


Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly 
                405                 410                 415     


Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Thr 
            420                 425                 430         


Leu Ala Pro Arg 
        435     


<210>  276
<211>  440
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - CAR construct

<400>  276

Asp Ala Val Val Thr Gln Glu Ser Ala Leu Thr Ser Ser Pro Gly Glu 
1               5                   10                  15      


Thr Val Thr Leu Thr Cys Arg Ser Ser Thr Gly Ala Val Thr Thr Ser 
            20                  25                  30          


Asn Tyr Ala Ser Trp Val Gln Glu Lys Pro Asp His Leu Phe Thr Gly 
        35                  40                  45              


Leu Ile Gly Gly Thr Asn Asn Arg Ala Pro Gly Val Pro Ala Arg Phe 
    50                  55                  60                  


Ser Gly Ser Leu Ile Gly Asp Lys Ala Ala Leu Thr Ile Thr Gly Ala 
65                  70                  75                  80  


Gln Thr Glu Asp Glu Ala Ile Tyr Phe Cys Val Leu Trp Tyr Ser Asp 
                85                  90                  95      


His Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Gly Gly 
            100                 105                 110         


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Asp Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Ala Pro 
    130                 135                 140                 


Ser Gln Ser Leu Ser Ile Thr Cys Thr Val Ser Gly Phe Leu Leu Thr 
145                 150                 155                 160 


Asp Tyr Gly Val Asn Trp Val Arg Gln Ser Pro Gly Lys Gly Leu Glu 
                165                 170                 175     


Trp Leu Gly Val Ile Trp Gly Asp Gly Ile Thr Asp Tyr Asn Ser Ala 
            180                 185                 190         


Leu Lys Ser Arg Leu Ser Val Thr Lys Asp Asn Ser Lys Ser Gln Val 
        195                 200                 205             


Phe Leu Lys Met Asn Ser Leu Gln Ser Gly Asp Ser Ala Arg Tyr Tyr 
    210                 215                 220                 


Cys Val Thr Gly Leu Phe Asp Tyr Trp Gly Gln Gly Thr Thr Leu Thr 
225                 230                 235                 240 


Val Ser Ser Glu Ser Lys Tyr Gly Pro Pro Cys Pro Pro Cys Pro Phe 
                245                 250                 255     


Trp Ala Leu Val Val Val Ala Gly Val Leu Phe Cys Tyr Gly Leu Leu 
            260                 265                 270         


Val Thr Val Ala Leu Cys Val Ile Trp Thr Lys Trp Ile Arg Lys Lys 
        275                 280                 285             


Phe Pro His Ile Phe Lys Gln Pro Phe Lys Lys Thr Thr Gly Ala Ala 
    290                 295                 300                 


Gln Glu Glu Asp Ala Cys Ser Cys Arg Cys Pro Gln Glu Glu Glu Gly 
305                 310                 315                 320 


Gly Gly Gly Gly Tyr Glu Leu Arg Ala Lys Phe Ser Arg Ser Ala Glu 
                325                 330                 335     


Thr Ala Ala Asn Leu Gln Asp Pro Asn Gln Leu Tyr Asn Glu Leu Asn 
            340                 345                 350         


Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Glu Lys Lys Arg Ala Arg 
        355                 360                 365             


Asp Pro Glu Met Gly Gly Lys Gln Gln Arg Arg Arg Asn Pro Gln Glu 
    370                 375                 380                 


Gly Val Tyr Asn Ala Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser 
385                 390                 395                 400 


Glu Ile Gly Thr Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly 
                405                 410                 415     


Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu 
            420                 425                 430         


His Met Gln Thr Leu Ala Pro Arg 
        435                 440 


<210>  277
<211>  481
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - CAR construct

<400>  277

Asp Ala Val Val Thr Gln Glu Ser Ala Leu Thr Ser Ser Pro Gly Glu 
1               5                   10                  15      


Thr Val Thr Leu Thr Cys Arg Ser Ser Thr Gly Ala Val Thr Thr Ser 
            20                  25                  30          


Asn Tyr Ala Ser Trp Val Gln Glu Lys Pro Asp His Leu Phe Thr Gly 
        35                  40                  45              


Leu Ile Gly Gly Thr Asn Asn Arg Ala Pro Gly Val Pro Ala Arg Phe 
    50                  55                  60                  


Ser Gly Ser Leu Ile Gly Asp Lys Ala Ala Leu Thr Ile Thr Gly Ala 
65                  70                  75                  80  


Gln Thr Glu Asp Glu Ala Ile Tyr Phe Cys Val Leu Trp Tyr Ser Asp 
                85                  90                  95      


His Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Gly Gly 
            100                 105                 110         


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Asp Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Ala Pro 
    130                 135                 140                 


Ser Gln Ser Leu Ser Ile Thr Cys Thr Val Ser Gly Phe Leu Leu Thr 
145                 150                 155                 160 


Asp Tyr Gly Val Asn Trp Val Arg Gln Ser Pro Gly Lys Gly Leu Glu 
                165                 170                 175     


Trp Leu Gly Val Ile Trp Gly Asp Gly Ile Thr Asp Tyr Asn Ser Ala 
            180                 185                 190         


Leu Lys Ser Arg Leu Ser Val Thr Lys Asp Asn Ser Lys Ser Gln Val 
        195                 200                 205             


Phe Leu Lys Met Asn Ser Leu Gln Ser Gly Asp Ser Ala Arg Tyr Tyr 
    210                 215                 220                 


Cys Val Thr Gly Leu Phe Asp Tyr Trp Gly Gln Gly Thr Thr Leu Thr 
225                 230                 235                 240 


Val Ser Ser Glu Ser Lys Tyr Gly Pro Pro Cys Pro Pro Cys Pro Phe 
                245                 250                 255     


Trp Ala Leu Val Val Val Ala Gly Val Leu Phe Cys Tyr Gly Leu Leu 
            260                 265                 270         


Val Thr Val Ala Leu Cys Val Ile Trp Thr Asn Ser Arg Arg Asn Arg 
        275                 280                 285             


Gly Gly Gln Ser Asp Tyr Met Asn Met Thr Pro Arg Arg Pro Gly Leu 
    290                 295                 300                 


Thr Arg Lys Pro Tyr Gln Pro Tyr Ala Pro Ala Arg Asp Phe Ala Ala 
305                 310                 315                 320 


Tyr Arg Pro Lys Trp Ile Arg Lys Lys Phe Pro His Ile Phe Lys Gln 
                325                 330                 335     


Pro Phe Lys Lys Thr Thr Gly Ala Ala Gln Glu Glu Asp Ala Cys Ser 
            340                 345                 350         


Cys Arg Cys Pro Gln Glu Glu Glu Gly Gly Gly Gly Gly Tyr Glu Leu 
        355                 360                 365             


Arg Ala Lys Phe Ser Arg Ser Ala Glu Thr Ala Ala Asn Leu Gln Asp 
    370                 375                 380                 


Pro Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr 
385                 390                 395                 400 


Asp Val Leu Glu Lys Lys Arg Ala Arg Asp Pro Glu Met Gly Gly Lys 
                405                 410                 415     


Gln Gln Arg Arg Arg Asn Pro Gln Glu Gly Val Tyr Asn Ala Leu Gln 
            420                 425                 430         


Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Thr Lys Gly Glu 
        435                 440                 445             


Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr 
    450                 455                 460                 


Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Thr Leu Ala Pro 
465                 470                 475                 480 


Arg 
    


<210>  278
<211>  464
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - CAR construct

<400>  278

Asp Ala Val Val Thr Gln Glu Ser Ala Leu Thr Ser Ser Pro Gly Glu 
1               5                   10                  15      


Thr Val Thr Leu Thr Cys Arg Ser Ser Thr Gly Ala Val Thr Thr Ser 
            20                  25                  30          


Asn Tyr Ala Ser Trp Val Gln Glu Lys Pro Asp His Leu Phe Thr Gly 
        35                  40                  45              


Leu Ile Gly Gly Thr Asn Asn Arg Ala Pro Gly Val Pro Ala Arg Phe 
    50                  55                  60                  


Ser Gly Ser Leu Ile Gly Asp Lys Ala Ala Leu Thr Ile Thr Gly Ala 
65                  70                  75                  80  


Gln Thr Glu Asp Glu Ala Ile Tyr Phe Cys Val Leu Trp Tyr Ser Asp 
                85                  90                  95      


His Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Gly Gly 
            100                 105                 110         


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Asp Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Ala Pro 
    130                 135                 140                 


Ser Gln Ser Leu Ser Ile Thr Cys Thr Val Ser Gly Phe Leu Leu Thr 
145                 150                 155                 160 


Asp Tyr Gly Val Asn Trp Val Arg Gln Ser Pro Gly Lys Gly Leu Glu 
                165                 170                 175     


Trp Leu Gly Val Ile Trp Gly Asp Gly Ile Thr Asp Tyr Asn Ser Ala 
            180                 185                 190         


Leu Lys Ser Arg Leu Ser Val Thr Lys Asp Asn Ser Lys Ser Gln Val 
        195                 200                 205             


Phe Leu Lys Met Asn Ser Leu Gln Ser Gly Asp Ser Ala Arg Tyr Tyr 
    210                 215                 220                 


Cys Val Thr Gly Leu Phe Asp Tyr Trp Gly Gln Gly Thr Thr Leu Thr 
225                 230                 235                 240 


Val Ser Ser Thr Thr Thr Lys Pro Val Leu Arg Thr Pro Ser Pro Val 
                245                 250                 255     


His Pro Thr Gly Thr Ser Gln Pro Gln Arg Pro Glu Asp Cys Arg Pro 
            260                 265                 270         


Arg Gly Ser Val Lys Gly Thr Gly Leu Asp Phe Ala Cys Asp Ile Tyr 
        275                 280                 285             


Ile Trp Ala Pro Leu Ala Gly Ile Cys Val Ala Leu Leu Leu Ser Leu 
    290                 295                 300                 


Ile Ile Thr Leu Ile Cys Asn Ser Arg Arg Asn Arg Gly Gly Gln Ser 
305                 310                 315                 320 


Asp Tyr Met Asn Met Thr Pro Arg Arg Pro Gly Leu Thr Arg Lys Pro 
                325                 330                 335     


Tyr Gln Pro Tyr Ala Pro Ala Arg Asp Phe Ala Ala Tyr Arg Pro Arg 
            340                 345                 350         


Ala Lys Phe Ser Arg Ser Ala Glu Thr Ala Ala Asn Leu Gln Asp Pro 
        355                 360                 365             


Asn Gln Leu Phe Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Phe Asp 
    370                 375                 380                 


Val Leu Glu Lys Lys Arg Ala Arg Asp Pro Glu Met Gly Gly Lys Gln 
385                 390                 395                 400 


Gln Arg Arg Arg Asn Pro Gln Glu Gly Val Tyr Asn Ala Leu Gln Lys 
                405                 410                 415     


Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Thr Lys Gly Glu Arg 
            420                 425                 430         


Arg Arg Gly Lys Gly His Asp Gly Leu Phe Gln Gly Leu Ser Thr Ala 
        435                 440                 445             


Thr Lys Asp Thr Phe Asp Ala Leu His Met Gln Thr Leu Ala Pro Arg 
    450                 455                 460                 


<210>  279
<211>  468
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - CAR construct

<400>  279

Asp Ala Val Val Thr Gln Glu Ser Ala Leu Thr Ser Ser Pro Gly Glu 
1               5                   10                  15      


Thr Val Thr Leu Thr Cys Arg Ser Ser Thr Gly Ala Val Thr Thr Ser 
            20                  25                  30          


Asn Tyr Ala Ser Trp Val Gln Glu Lys Pro Asp His Leu Phe Thr Gly 
        35                  40                  45              


Leu Ile Gly Gly Thr Asn Asn Arg Ala Pro Gly Val Pro Ala Arg Phe 
    50                  55                  60                  


Ser Gly Ser Leu Ile Gly Asp Lys Ala Ala Leu Thr Ile Thr Gly Ala 
65                  70                  75                  80  


Gln Thr Glu Asp Glu Ala Ile Tyr Phe Cys Val Leu Trp Tyr Ser Asp 
                85                  90                  95      


His Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Gly Gly 
            100                 105                 110         


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Asp Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Ala Pro 
    130                 135                 140                 


Ser Gln Ser Leu Ser Ile Thr Cys Thr Val Ser Gly Phe Leu Leu Thr 
145                 150                 155                 160 


Asp Tyr Gly Val Asn Trp Val Arg Gln Ser Pro Gly Lys Gly Leu Glu 
                165                 170                 175     


Trp Leu Gly Val Ile Trp Gly Asp Gly Ile Thr Asp Tyr Asn Ser Ala 
            180                 185                 190         


Leu Lys Ser Arg Leu Ser Val Thr Lys Asp Asn Ser Lys Ser Gln Val 
        195                 200                 205             


Phe Leu Lys Met Asn Ser Leu Gln Ser Gly Asp Ser Ala Arg Tyr Tyr 
    210                 215                 220                 


Cys Val Thr Gly Leu Phe Asp Tyr Trp Gly Gln Gly Thr Thr Leu Thr 
225                 230                 235                 240 


Val Ser Ser Thr Thr Thr Lys Pro Val Leu Arg Thr Pro Ser Pro Val 
                245                 250                 255     


His Pro Thr Gly Thr Ser Gln Pro Gln Arg Pro Glu Asp Cys Arg Pro 
            260                 265                 270         


Arg Gly Ser Val Lys Gly Thr Gly Leu Asp Phe Ala Cys Asp Ile Tyr 
        275                 280                 285             


Ile Trp Ala Pro Leu Ala Gly Ile Cys Val Ala Leu Leu Leu Ser Leu 
    290                 295                 300                 


Ile Ile Thr Leu Ile Cys Lys Trp Ile Arg Lys Lys Phe Pro His Ile 
305                 310                 315                 320 


Phe Lys Gln Pro Phe Lys Lys Thr Thr Gly Ala Ala Gln Glu Glu Asp 
                325                 330                 335     


Ala Cys Ser Cys Arg Cys Pro Gln Glu Glu Glu Gly Gly Gly Gly Gly 
            340                 345                 350         


Tyr Glu Leu Arg Ala Lys Phe Ser Arg Ser Ala Glu Thr Ala Ala Asn 
        355                 360                 365             


Leu Gln Asp Pro Asn Gln Leu Phe Asn Glu Leu Asn Leu Gly Arg Arg 
    370                 375                 380                 


Glu Glu Phe Asp Val Leu Glu Lys Lys Arg Ala Arg Asp Pro Glu Met 
385                 390                 395                 400 


Gly Gly Lys Gln Gln Arg Arg Arg Asn Pro Gln Glu Gly Val Tyr Asn 
                405                 410                 415     


Ala Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Thr 
            420                 425                 430         


Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Phe Gln Gly 
        435                 440                 445             


Leu Ser Thr Ala Thr Lys Asp Thr Phe Asp Ala Leu His Met Gln Thr 
    450                 455                 460                 


Leu Ala Pro Arg 
465             


<210>  280
<211>  509
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - CAR construct

<400>  280

Asp Ala Val Val Thr Gln Glu Ser Ala Leu Thr Ser Ser Pro Gly Glu 
1               5                   10                  15      


Thr Val Thr Leu Thr Cys Arg Ser Ser Thr Gly Ala Val Thr Thr Ser 
            20                  25                  30          


Asn Tyr Ala Ser Trp Val Gln Glu Lys Pro Asp His Leu Phe Thr Gly 
        35                  40                  45              


Leu Ile Gly Gly Thr Asn Asn Arg Ala Pro Gly Val Pro Ala Arg Phe 
    50                  55                  60                  


Ser Gly Ser Leu Ile Gly Asp Lys Ala Ala Leu Thr Ile Thr Gly Ala 
65                  70                  75                  80  


Gln Thr Glu Asp Glu Ala Ile Tyr Phe Cys Val Leu Trp Tyr Ser Asp 
                85                  90                  95      


His Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Gly Gly 
            100                 105                 110         


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Asp Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Ala Pro 
    130                 135                 140                 


Ser Gln Ser Leu Ser Ile Thr Cys Thr Val Ser Gly Phe Leu Leu Thr 
145                 150                 155                 160 


Asp Tyr Gly Val Asn Trp Val Arg Gln Ser Pro Gly Lys Gly Leu Glu 
                165                 170                 175     


Trp Leu Gly Val Ile Trp Gly Asp Gly Ile Thr Asp Tyr Asn Ser Ala 
            180                 185                 190         


Leu Lys Ser Arg Leu Ser Val Thr Lys Asp Asn Ser Lys Ser Gln Val 
        195                 200                 205             


Phe Leu Lys Met Asn Ser Leu Gln Ser Gly Asp Ser Ala Arg Tyr Tyr 
    210                 215                 220                 


Cys Val Thr Gly Leu Phe Asp Tyr Trp Gly Gln Gly Thr Thr Leu Thr 
225                 230                 235                 240 


Val Ser Ser Thr Thr Thr Lys Pro Val Leu Arg Thr Pro Ser Pro Val 
                245                 250                 255     


His Pro Thr Gly Thr Ser Gln Pro Gln Arg Pro Glu Asp Cys Arg Pro 
            260                 265                 270         


Arg Gly Ser Val Lys Gly Thr Gly Leu Asp Phe Ala Cys Asp Ile Tyr 
        275                 280                 285             


Ile Trp Ala Pro Leu Ala Gly Ile Cys Val Ala Leu Leu Leu Ser Leu 
    290                 295                 300                 


Ile Ile Thr Leu Ile Cys Asn Ser Arg Arg Asn Arg Gly Gly Gln Ser 
305                 310                 315                 320 


Asp Tyr Met Asn Met Thr Pro Arg Arg Pro Gly Leu Thr Arg Lys Pro 
                325                 330                 335     


Tyr Gln Pro Tyr Ala Pro Ala Arg Asp Phe Ala Ala Tyr Arg Pro Lys 
            340                 345                 350         


Trp Ile Arg Lys Lys Phe Pro His Ile Phe Lys Gln Pro Phe Lys Lys 
        355                 360                 365             


Thr Thr Gly Ala Ala Gln Glu Glu Asp Ala Cys Ser Cys Arg Cys Pro 
    370                 375                 380                 


Gln Glu Glu Glu Gly Gly Gly Gly Gly Tyr Glu Leu Arg Ala Lys Phe 
385                 390                 395                 400 


Ser Arg Ser Ala Glu Thr Ala Ala Asn Leu Gln Asp Pro Asn Gln Leu 
                405                 410                 415     


Phe Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Phe Asp Val Leu Glu 
            420                 425                 430         


Lys Lys Arg Ala Arg Asp Pro Glu Met Gly Gly Lys Gln Gln Arg Arg 
        435                 440                 445             


Arg Asn Pro Gln Glu Gly Val Tyr Asn Ala Leu Gln Lys Asp Lys Met 
    450                 455                 460                 


Ala Glu Ala Tyr Ser Glu Ile Gly Thr Lys Gly Glu Arg Arg Arg Gly 
465                 470                 475                 480 


Lys Gly His Asp Gly Leu Phe Gln Gly Leu Ser Thr Ala Thr Lys Asp 
                485                 490                 495     


Thr Phe Asp Ala Leu His Met Gln Thr Leu Ala Pro Arg 
            500                 505                 


<210>  281
<211>  464
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - CAR construct

<400>  281

Asp Ala Val Val Thr Gln Glu Ser Ala Leu Thr Ser Ser Pro Gly Glu 
1               5                   10                  15      


Thr Val Thr Leu Thr Cys Arg Ser Ser Thr Gly Ala Val Thr Thr Ser 
            20                  25                  30          


Asn Tyr Ala Ser Trp Val Gln Glu Lys Pro Asp His Leu Phe Thr Gly 
        35                  40                  45              


Leu Ile Gly Gly Thr Asn Asn Arg Ala Pro Gly Val Pro Ala Arg Phe 
    50                  55                  60                  


Ser Gly Ser Leu Ile Gly Asp Lys Ala Ala Leu Thr Ile Thr Gly Ala 
65                  70                  75                  80  


Gln Thr Glu Asp Glu Ala Ile Tyr Phe Cys Val Leu Trp Tyr Ser Asp 
                85                  90                  95      


His Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Gly Gly 
            100                 105                 110         


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Asp Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Ala Pro 
    130                 135                 140                 


Ser Gln Ser Leu Ser Ile Thr Cys Thr Val Ser Gly Phe Leu Leu Thr 
145                 150                 155                 160 


Asp Tyr Gly Val Asn Trp Val Arg Gln Ser Pro Gly Lys Gly Leu Glu 
                165                 170                 175     


Trp Leu Gly Val Ile Trp Gly Asp Gly Ile Thr Asp Tyr Asn Ser Ala 
            180                 185                 190         


Leu Lys Ser Arg Leu Ser Val Thr Lys Asp Asn Ser Lys Ser Gln Val 
        195                 200                 205             


Phe Leu Lys Met Asn Ser Leu Gln Ser Gly Asp Ser Ala Arg Tyr Tyr 
    210                 215                 220                 


Cys Val Thr Gly Leu Phe Asp Tyr Trp Gly Gln Gly Thr Thr Leu Thr 
225                 230                 235                 240 


Val Ser Ser Thr Thr Thr Lys Pro Val Leu Arg Thr Pro Ser Pro Val 
                245                 250                 255     


His Pro Thr Gly Thr Ser Gln Pro Gln Arg Pro Glu Asp Cys Arg Pro 
            260                 265                 270         


Arg Gly Ser Val Lys Gly Thr Gly Leu Asp Phe Ala Cys Asp Ile Tyr 
        275                 280                 285             


Ile Trp Ala Pro Leu Ala Gly Ile Cys Val Ala Leu Leu Leu Ser Leu 
    290                 295                 300                 


Ile Ile Thr Leu Ile Cys Asn Ser Arg Arg Asn Arg Gly Gly Gln Ser 
305                 310                 315                 320 


Asp Tyr Met Asn Met Thr Pro Arg Arg Pro Gly Leu Thr Arg Lys Pro 
                325                 330                 335     


Tyr Gln Pro Tyr Ala Pro Ala Arg Asp Phe Ala Ala Tyr Arg Pro Arg 
            340                 345                 350         


Ala Lys Phe Ser Arg Ser Ala Glu Thr Ala Ala Asn Leu Gln Asp Pro 
        355                 360                 365             


Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp 
    370                 375                 380                 


Val Leu Glu Lys Lys Arg Ala Arg Asp Pro Glu Met Gly Gly Lys Gln 
385                 390                 395                 400 


Gln Arg Arg Arg Asn Pro Gln Glu Gly Val Tyr Asn Ala Leu Gln Lys 
                405                 410                 415     


Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Thr Lys Gly Glu Arg 
            420                 425                 430         


Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala 
        435                 440                 445             


Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Thr Leu Ala Pro Arg 
    450                 455                 460                 


<210>  282
<211>  468
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - CAR construct

<400>  282

Asp Ala Val Val Thr Gln Glu Ser Ala Leu Thr Ser Ser Pro Gly Glu 
1               5                   10                  15      


Thr Val Thr Leu Thr Cys Arg Ser Ser Thr Gly Ala Val Thr Thr Ser 
            20                  25                  30          


Asn Tyr Ala Ser Trp Val Gln Glu Lys Pro Asp His Leu Phe Thr Gly 
        35                  40                  45              


Leu Ile Gly Gly Thr Asn Asn Arg Ala Pro Gly Val Pro Ala Arg Phe 
    50                  55                  60                  


Ser Gly Ser Leu Ile Gly Asp Lys Ala Ala Leu Thr Ile Thr Gly Ala 
65                  70                  75                  80  


Gln Thr Glu Asp Glu Ala Ile Tyr Phe Cys Val Leu Trp Tyr Ser Asp 
                85                  90                  95      


His Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Gly Gly 
            100                 105                 110         


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Asp Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Ala Pro 
    130                 135                 140                 


Ser Gln Ser Leu Ser Ile Thr Cys Thr Val Ser Gly Phe Leu Leu Thr 
145                 150                 155                 160 


Asp Tyr Gly Val Asn Trp Val Arg Gln Ser Pro Gly Lys Gly Leu Glu 
                165                 170                 175     


Trp Leu Gly Val Ile Trp Gly Asp Gly Ile Thr Asp Tyr Asn Ser Ala 
            180                 185                 190         


Leu Lys Ser Arg Leu Ser Val Thr Lys Asp Asn Ser Lys Ser Gln Val 
        195                 200                 205             


Phe Leu Lys Met Asn Ser Leu Gln Ser Gly Asp Ser Ala Arg Tyr Tyr 
    210                 215                 220                 


Cys Val Thr Gly Leu Phe Asp Tyr Trp Gly Gln Gly Thr Thr Leu Thr 
225                 230                 235                 240 


Val Ser Ser Thr Thr Thr Lys Pro Val Leu Arg Thr Pro Ser Pro Val 
                245                 250                 255     


His Pro Thr Gly Thr Ser Gln Pro Gln Arg Pro Glu Asp Cys Arg Pro 
            260                 265                 270         


Arg Gly Ser Val Lys Gly Thr Gly Leu Asp Phe Ala Cys Asp Ile Tyr 
        275                 280                 285             


Ile Trp Ala Pro Leu Ala Gly Ile Cys Val Ala Leu Leu Leu Ser Leu 
    290                 295                 300                 


Ile Ile Thr Leu Ile Cys Lys Trp Ile Arg Lys Lys Phe Pro His Ile 
305                 310                 315                 320 


Phe Lys Gln Pro Phe Lys Lys Thr Thr Gly Ala Ala Gln Glu Glu Asp 
                325                 330                 335     


Ala Cys Ser Cys Arg Cys Pro Gln Glu Glu Glu Gly Gly Gly Gly Gly 
            340                 345                 350         


Tyr Glu Leu Arg Ala Lys Phe Ser Arg Ser Ala Glu Thr Ala Ala Asn 
        355                 360                 365             


Leu Gln Asp Pro Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg 
    370                 375                 380                 


Glu Glu Tyr Asp Val Leu Glu Lys Lys Arg Ala Arg Asp Pro Glu Met 
385                 390                 395                 400 


Gly Gly Lys Gln Gln Arg Arg Arg Asn Pro Gln Glu Gly Val Tyr Asn 
                405                 410                 415     


Ala Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Thr 
            420                 425                 430         


Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly 
        435                 440                 445             


Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Thr 
    450                 455                 460                 


Leu Ala Pro Arg 
465             


<210>  283
<211>  509
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - CAR construct

<400>  283

Asp Ala Val Val Thr Gln Glu Ser Ala Leu Thr Ser Ser Pro Gly Glu 
1               5                   10                  15      


Thr Val Thr Leu Thr Cys Arg Ser Ser Thr Gly Ala Val Thr Thr Ser 
            20                  25                  30          


Asn Tyr Ala Ser Trp Val Gln Glu Lys Pro Asp His Leu Phe Thr Gly 
        35                  40                  45              


Leu Ile Gly Gly Thr Asn Asn Arg Ala Pro Gly Val Pro Ala Arg Phe 
    50                  55                  60                  


Ser Gly Ser Leu Ile Gly Asp Lys Ala Ala Leu Thr Ile Thr Gly Ala 
65                  70                  75                  80  


Gln Thr Glu Asp Glu Ala Ile Tyr Phe Cys Val Leu Trp Tyr Ser Asp 
                85                  90                  95      


His Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Gly Gly 
            100                 105                 110         


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Asp Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Ala Pro 
    130                 135                 140                 


Ser Gln Ser Leu Ser Ile Thr Cys Thr Val Ser Gly Phe Leu Leu Thr 
145                 150                 155                 160 


Asp Tyr Gly Val Asn Trp Val Arg Gln Ser Pro Gly Lys Gly Leu Glu 
                165                 170                 175     


Trp Leu Gly Val Ile Trp Gly Asp Gly Ile Thr Asp Tyr Asn Ser Ala 
            180                 185                 190         


Leu Lys Ser Arg Leu Ser Val Thr Lys Asp Asn Ser Lys Ser Gln Val 
        195                 200                 205             


Phe Leu Lys Met Asn Ser Leu Gln Ser Gly Asp Ser Ala Arg Tyr Tyr 
    210                 215                 220                 


Cys Val Thr Gly Leu Phe Asp Tyr Trp Gly Gln Gly Thr Thr Leu Thr 
225                 230                 235                 240 


Val Ser Ser Thr Thr Thr Lys Pro Val Leu Arg Thr Pro Ser Pro Val 
                245                 250                 255     


His Pro Thr Gly Thr Ser Gln Pro Gln Arg Pro Glu Asp Cys Arg Pro 
            260                 265                 270         


Arg Gly Ser Val Lys Gly Thr Gly Leu Asp Phe Ala Cys Asp Ile Tyr 
        275                 280                 285             


Ile Trp Ala Pro Leu Ala Gly Ile Cys Val Ala Leu Leu Leu Ser Leu 
    290                 295                 300                 


Ile Ile Thr Leu Ile Cys Asn Ser Arg Arg Asn Arg Gly Gly Gln Ser 
305                 310                 315                 320 


Asp Tyr Met Asn Met Thr Pro Arg Arg Pro Gly Leu Thr Arg Lys Pro 
                325                 330                 335     


Tyr Gln Pro Tyr Ala Pro Ala Arg Asp Phe Ala Ala Tyr Arg Pro Lys 
            340                 345                 350         


Trp Ile Arg Lys Lys Phe Pro His Ile Phe Lys Gln Pro Phe Lys Lys 
        355                 360                 365             


Thr Thr Gly Ala Ala Gln Glu Glu Asp Ala Cys Ser Cys Arg Cys Pro 
    370                 375                 380                 


Gln Glu Glu Glu Gly Gly Gly Gly Gly Tyr Glu Leu Arg Ala Lys Phe 
385                 390                 395                 400 


Ser Arg Ser Ala Glu Thr Ala Ala Asn Leu Gln Asp Pro Asn Gln Leu 
                405                 410                 415     


Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Glu 
            420                 425                 430         


Lys Lys Arg Ala Arg Asp Pro Glu Met Gly Gly Lys Gln Gln Arg Arg 
        435                 440                 445             


Arg Asn Pro Gln Glu Gly Val Tyr Asn Ala Leu Gln Lys Asp Lys Met 
    450                 455                 460                 


Ala Glu Ala Tyr Ser Glu Ile Gly Thr Lys Gly Glu Arg Arg Arg Gly 
465                 470                 475                 480 


Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp 
                485                 490                 495     


Thr Tyr Asp Ala Leu His Met Gln Thr Leu Ala Pro Arg 
            500                 505                 


<210>  284
<211>  433
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - CAR construct

<400>  284

Asp Ala Val Val Thr Gln Glu Ser Ala Leu Thr Ser Ser Pro Gly Glu 
1               5                   10                  15      


Thr Val Thr Leu Thr Cys Arg Ser Ser Thr Gly Ala Val Thr Thr Ser 
            20                  25                  30          


Asn Tyr Ala Ser Trp Val Gln Glu Lys Pro Asp His Leu Phe Thr Gly 
        35                  40                  45              


Leu Ile Gly Gly Thr Asn Asn Arg Ala Pro Gly Val Pro Ala Arg Phe 
    50                  55                  60                  


Ser Gly Ser Leu Ile Gly Asp Lys Ala Ala Leu Thr Ile Thr Gly Ala 
65                  70                  75                  80  


Gln Thr Glu Asp Glu Ala Ile Tyr Phe Cys Val Leu Trp Tyr Ser Asp 
                85                  90                  95      


His Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Gly Gly 
            100                 105                 110         


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Asp Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Ala Pro 
    130                 135                 140                 


Ser Gln Ser Leu Ser Ile Thr Cys Thr Val Ser Gly Phe Leu Leu Thr 
145                 150                 155                 160 


Asp Tyr Gly Val Asn Trp Val Arg Gln Ser Pro Gly Lys Gly Leu Glu 
                165                 170                 175     


Trp Leu Gly Val Ile Trp Gly Asp Gly Ile Thr Asp Tyr Asn Ser Ala 
            180                 185                 190         


Leu Lys Ser Arg Leu Ser Val Thr Lys Asp Asn Ser Lys Ser Gln Val 
        195                 200                 205             


Phe Leu Lys Met Asn Ser Leu Gln Ser Gly Asp Ser Ala Arg Tyr Tyr 
    210                 215                 220                 


Cys Val Thr Gly Leu Phe Asp Tyr Trp Gly Gln Gly Thr Thr Leu Thr 
225                 230                 235                 240 


Val Ser Ser Glu Ser Lys Tyr Gly Pro Pro Cys Pro Pro Cys Pro Ile 
                245                 250                 255     


Tyr Ile Trp Ala Pro Leu Ala Gly Ile Cys Val Ala Leu Leu Leu Ser 
            260                 265                 270         


Leu Ile Ile Thr Leu Ile Cys Asn Ser Arg Arg Asn Arg Gly Gly Gln 
        275                 280                 285             


Ser Asp Tyr Met Asn Met Thr Pro Arg Arg Pro Gly Leu Thr Arg Lys 
    290                 295                 300                 


Pro Tyr Gln Pro Tyr Ala Pro Ala Arg Asp Phe Ala Ala Tyr Arg Pro 
305                 310                 315                 320 


Arg Ala Lys Phe Ser Arg Ser Ala Glu Thr Ala Ala Asn Leu Gln Asp 
                325                 330                 335     


Pro Asn Gln Leu Phe Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Phe 
            340                 345                 350         


Asp Val Leu Glu Lys Lys Arg Ala Arg Asp Pro Glu Met Gly Gly Lys 
        355                 360                 365             


Gln Gln Arg Arg Arg Asn Pro Gln Glu Gly Val Tyr Asn Ala Leu Gln 
    370                 375                 380                 


Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Thr Lys Gly Glu 
385                 390                 395                 400 


Arg Arg Arg Gly Lys Gly His Asp Gly Leu Phe Gln Gly Leu Ser Thr 
                405                 410                 415     


Ala Thr Lys Asp Thr Phe Asp Ala Leu His Met Gln Thr Leu Ala Pro 
            420                 425                 430         


Arg 
    


<210>  285
<211>  437
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - CAR construct

<400>  285

Asp Ala Val Val Thr Gln Glu Ser Ala Leu Thr Ser Ser Pro Gly Glu 
1               5                   10                  15      


Thr Val Thr Leu Thr Cys Arg Ser Ser Thr Gly Ala Val Thr Thr Ser 
            20                  25                  30          


Asn Tyr Ala Ser Trp Val Gln Glu Lys Pro Asp His Leu Phe Thr Gly 
        35                  40                  45              


Leu Ile Gly Gly Thr Asn Asn Arg Ala Pro Gly Val Pro Ala Arg Phe 
    50                  55                  60                  


Ser Gly Ser Leu Ile Gly Asp Lys Ala Ala Leu Thr Ile Thr Gly Ala 
65                  70                  75                  80  


Gln Thr Glu Asp Glu Ala Ile Tyr Phe Cys Val Leu Trp Tyr Ser Asp 
                85                  90                  95      


His Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Gly Gly 
            100                 105                 110         


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Asp Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Ala Pro 
    130                 135                 140                 


Ser Gln Ser Leu Ser Ile Thr Cys Thr Val Ser Gly Phe Leu Leu Thr 
145                 150                 155                 160 


Asp Tyr Gly Val Asn Trp Val Arg Gln Ser Pro Gly Lys Gly Leu Glu 
                165                 170                 175     


Trp Leu Gly Val Ile Trp Gly Asp Gly Ile Thr Asp Tyr Asn Ser Ala 
            180                 185                 190         


Leu Lys Ser Arg Leu Ser Val Thr Lys Asp Asn Ser Lys Ser Gln Val 
        195                 200                 205             


Phe Leu Lys Met Asn Ser Leu Gln Ser Gly Asp Ser Ala Arg Tyr Tyr 
    210                 215                 220                 


Cys Val Thr Gly Leu Phe Asp Tyr Trp Gly Gln Gly Thr Thr Leu Thr 
225                 230                 235                 240 


Val Ser Ser Glu Ser Lys Tyr Gly Pro Pro Cys Pro Pro Cys Pro Ile 
                245                 250                 255     


Tyr Ile Trp Ala Pro Leu Ala Gly Ile Cys Val Ala Leu Leu Leu Ser 
            260                 265                 270         


Leu Ile Ile Thr Leu Ile Cys Lys Trp Ile Arg Lys Lys Phe Pro His 
        275                 280                 285             


Ile Phe Lys Gln Pro Phe Lys Lys Thr Thr Gly Ala Ala Gln Glu Glu 
    290                 295                 300                 


Asp Ala Cys Ser Cys Arg Cys Pro Gln Glu Glu Glu Gly Gly Gly Gly 
305                 310                 315                 320 


Gly Tyr Glu Leu Arg Ala Lys Phe Ser Arg Ser Ala Glu Thr Ala Ala 
                325                 330                 335     


Asn Leu Gln Asp Pro Asn Gln Leu Phe Asn Glu Leu Asn Leu Gly Arg 
            340                 345                 350         


Arg Glu Glu Phe Asp Val Leu Glu Lys Lys Arg Ala Arg Asp Pro Glu 
        355                 360                 365             


Met Gly Gly Lys Gln Gln Arg Arg Arg Asn Pro Gln Glu Gly Val Tyr 
    370                 375                 380                 


Asn Ala Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly 
385                 390                 395                 400 


Thr Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Phe Gln 
                405                 410                 415     


Gly Leu Ser Thr Ala Thr Lys Asp Thr Phe Asp Ala Leu His Met Gln 
            420                 425                 430         


Thr Leu Ala Pro Arg 
        435         


<210>  286
<211>  478
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - CAR construct

<400>  286

Asp Ala Val Val Thr Gln Glu Ser Ala Leu Thr Ser Ser Pro Gly Glu 
1               5                   10                  15      


Thr Val Thr Leu Thr Cys Arg Ser Ser Thr Gly Ala Val Thr Thr Ser 
            20                  25                  30          


Asn Tyr Ala Ser Trp Val Gln Glu Lys Pro Asp His Leu Phe Thr Gly 
        35                  40                  45              


Leu Ile Gly Gly Thr Asn Asn Arg Ala Pro Gly Val Pro Ala Arg Phe 
    50                  55                  60                  


Ser Gly Ser Leu Ile Gly Asp Lys Ala Ala Leu Thr Ile Thr Gly Ala 
65                  70                  75                  80  


Gln Thr Glu Asp Glu Ala Ile Tyr Phe Cys Val Leu Trp Tyr Ser Asp 
                85                  90                  95      


His Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Gly Gly 
            100                 105                 110         


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Asp Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Ala Pro 
    130                 135                 140                 


Ser Gln Ser Leu Ser Ile Thr Cys Thr Val Ser Gly Phe Leu Leu Thr 
145                 150                 155                 160 


Asp Tyr Gly Val Asn Trp Val Arg Gln Ser Pro Gly Lys Gly Leu Glu 
                165                 170                 175     


Trp Leu Gly Val Ile Trp Gly Asp Gly Ile Thr Asp Tyr Asn Ser Ala 
            180                 185                 190         


Leu Lys Ser Arg Leu Ser Val Thr Lys Asp Asn Ser Lys Ser Gln Val 
        195                 200                 205             


Phe Leu Lys Met Asn Ser Leu Gln Ser Gly Asp Ser Ala Arg Tyr Tyr 
    210                 215                 220                 


Cys Val Thr Gly Leu Phe Asp Tyr Trp Gly Gln Gly Thr Thr Leu Thr 
225                 230                 235                 240 


Val Ser Ser Glu Ser Lys Tyr Gly Pro Pro Cys Pro Pro Cys Pro Ile 
                245                 250                 255     


Tyr Ile Trp Ala Pro Leu Ala Gly Ile Cys Val Ala Leu Leu Leu Ser 
            260                 265                 270         


Leu Ile Ile Thr Leu Ile Cys Asn Ser Arg Arg Asn Arg Gly Gly Gln 
        275                 280                 285             


Ser Asp Tyr Met Asn Met Thr Pro Arg Arg Pro Gly Leu Thr Arg Lys 
    290                 295                 300                 


Pro Tyr Gln Pro Tyr Ala Pro Ala Arg Asp Phe Ala Ala Tyr Arg Pro 
305                 310                 315                 320 


Lys Trp Ile Arg Lys Lys Phe Pro His Ile Phe Lys Gln Pro Phe Lys 
                325                 330                 335     


Lys Thr Thr Gly Ala Ala Gln Glu Glu Asp Ala Cys Ser Cys Arg Cys 
            340                 345                 350         


Pro Gln Glu Glu Glu Gly Gly Gly Gly Gly Tyr Glu Leu Arg Ala Lys 
        355                 360                 365             


Phe Ser Arg Ser Ala Glu Thr Ala Ala Asn Leu Gln Asp Pro Asn Gln 
    370                 375                 380                 


Leu Phe Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Phe Asp Val Leu 
385                 390                 395                 400 


Glu Lys Lys Arg Ala Arg Asp Pro Glu Met Gly Gly Lys Gln Gln Arg 
                405                 410                 415     


Arg Arg Asn Pro Gln Glu Gly Val Tyr Asn Ala Leu Gln Lys Asp Lys 
            420                 425                 430         


Met Ala Glu Ala Tyr Ser Glu Ile Gly Thr Lys Gly Glu Arg Arg Arg 
        435                 440                 445             


Gly Lys Gly His Asp Gly Leu Phe Gln Gly Leu Ser Thr Ala Thr Lys 
    450                 455                 460                 


Asp Thr Phe Asp Ala Leu His Met Gln Thr Leu Ala Pro Arg 
465                 470                 475             


<210>  287
<211>  433
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - CAR construct

<400>  287

Asp Ala Val Val Thr Gln Glu Ser Ala Leu Thr Ser Ser Pro Gly Glu 
1               5                   10                  15      


Thr Val Thr Leu Thr Cys Arg Ser Ser Thr Gly Ala Val Thr Thr Ser 
            20                  25                  30          


Asn Tyr Ala Ser Trp Val Gln Glu Lys Pro Asp His Leu Phe Thr Gly 
        35                  40                  45              


Leu Ile Gly Gly Thr Asn Asn Arg Ala Pro Gly Val Pro Ala Arg Phe 
    50                  55                  60                  


Ser Gly Ser Leu Ile Gly Asp Lys Ala Ala Leu Thr Ile Thr Gly Ala 
65                  70                  75                  80  


Gln Thr Glu Asp Glu Ala Ile Tyr Phe Cys Val Leu Trp Tyr Ser Asp 
                85                  90                  95      


His Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Gly Gly 
            100                 105                 110         


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Asp Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Ala Pro 
    130                 135                 140                 


Ser Gln Ser Leu Ser Ile Thr Cys Thr Val Ser Gly Phe Leu Leu Thr 
145                 150                 155                 160 


Asp Tyr Gly Val Asn Trp Val Arg Gln Ser Pro Gly Lys Gly Leu Glu 
                165                 170                 175     


Trp Leu Gly Val Ile Trp Gly Asp Gly Ile Thr Asp Tyr Asn Ser Ala 
            180                 185                 190         


Leu Lys Ser Arg Leu Ser Val Thr Lys Asp Asn Ser Lys Ser Gln Val 
        195                 200                 205             


Phe Leu Lys Met Asn Ser Leu Gln Ser Gly Asp Ser Ala Arg Tyr Tyr 
    210                 215                 220                 


Cys Val Thr Gly Leu Phe Asp Tyr Trp Gly Gln Gly Thr Thr Leu Thr 
225                 230                 235                 240 


Val Ser Ser Glu Ser Lys Tyr Gly Pro Pro Cys Pro Pro Cys Pro Ile 
                245                 250                 255     


Tyr Ile Trp Ala Pro Leu Ala Gly Ile Cys Val Ala Leu Leu Leu Ser 
            260                 265                 270         


Leu Ile Ile Thr Leu Ile Cys Asn Ser Arg Arg Asn Arg Gly Gly Gln 
        275                 280                 285             


Ser Asp Tyr Met Asn Met Thr Pro Arg Arg Pro Gly Leu Thr Arg Lys 
    290                 295                 300                 


Pro Tyr Gln Pro Tyr Ala Pro Ala Arg Asp Phe Ala Ala Tyr Arg Pro 
305                 310                 315                 320 


Arg Ala Lys Phe Ser Arg Ser Ala Glu Thr Ala Ala Asn Leu Gln Asp 
                325                 330                 335     


Pro Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr 
            340                 345                 350         


Asp Val Leu Glu Lys Lys Arg Ala Arg Asp Pro Glu Met Gly Gly Lys 
        355                 360                 365             


Gln Gln Arg Arg Arg Asn Pro Gln Glu Gly Val Tyr Asn Ala Leu Gln 
    370                 375                 380                 


Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Thr Lys Gly Glu 
385                 390                 395                 400 


Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr 
                405                 410                 415     


Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Thr Leu Ala Pro 
            420                 425                 430         


Arg 
    


<210>  288
<211>  437
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - CAR construct

<400>  288

Asp Ala Val Val Thr Gln Glu Ser Ala Leu Thr Ser Ser Pro Gly Glu 
1               5                   10                  15      


Thr Val Thr Leu Thr Cys Arg Ser Ser Thr Gly Ala Val Thr Thr Ser 
            20                  25                  30          


Asn Tyr Ala Ser Trp Val Gln Glu Lys Pro Asp His Leu Phe Thr Gly 
        35                  40                  45              


Leu Ile Gly Gly Thr Asn Asn Arg Ala Pro Gly Val Pro Ala Arg Phe 
    50                  55                  60                  


Ser Gly Ser Leu Ile Gly Asp Lys Ala Ala Leu Thr Ile Thr Gly Ala 
65                  70                  75                  80  


Gln Thr Glu Asp Glu Ala Ile Tyr Phe Cys Val Leu Trp Tyr Ser Asp 
                85                  90                  95      


His Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Gly Gly 
            100                 105                 110         


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Asp Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Ala Pro 
    130                 135                 140                 


Ser Gln Ser Leu Ser Ile Thr Cys Thr Val Ser Gly Phe Leu Leu Thr 
145                 150                 155                 160 


Asp Tyr Gly Val Asn Trp Val Arg Gln Ser Pro Gly Lys Gly Leu Glu 
                165                 170                 175     


Trp Leu Gly Val Ile Trp Gly Asp Gly Ile Thr Asp Tyr Asn Ser Ala 
            180                 185                 190         


Leu Lys Ser Arg Leu Ser Val Thr Lys Asp Asn Ser Lys Ser Gln Val 
        195                 200                 205             


Phe Leu Lys Met Asn Ser Leu Gln Ser Gly Asp Ser Ala Arg Tyr Tyr 
    210                 215                 220                 


Cys Val Thr Gly Leu Phe Asp Tyr Trp Gly Gln Gly Thr Thr Leu Thr 
225                 230                 235                 240 


Val Ser Ser Glu Ser Lys Tyr Gly Pro Pro Cys Pro Pro Cys Pro Ile 
                245                 250                 255     


Tyr Ile Trp Ala Pro Leu Ala Gly Ile Cys Val Ala Leu Leu Leu Ser 
            260                 265                 270         


Leu Ile Ile Thr Leu Ile Cys Lys Trp Ile Arg Lys Lys Phe Pro His 
        275                 280                 285             


Ile Phe Lys Gln Pro Phe Lys Lys Thr Thr Gly Ala Ala Gln Glu Glu 
    290                 295                 300                 


Asp Ala Cys Ser Cys Arg Cys Pro Gln Glu Glu Glu Gly Gly Gly Gly 
305                 310                 315                 320 


Gly Tyr Glu Leu Arg Ala Lys Phe Ser Arg Ser Ala Glu Thr Ala Ala 
                325                 330                 335     


Asn Leu Gln Asp Pro Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg 
            340                 345                 350         


Arg Glu Glu Tyr Asp Val Leu Glu Lys Lys Arg Ala Arg Asp Pro Glu 
        355                 360                 365             


Met Gly Gly Lys Gln Gln Arg Arg Arg Asn Pro Gln Glu Gly Val Tyr 
    370                 375                 380                 


Asn Ala Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly 
385                 390                 395                 400 


Thr Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln 
                405                 410                 415     


Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln 
            420                 425                 430         


Thr Leu Ala Pro Arg 
        435         


<210>  289
<211>  478
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - CAR construct

<400>  289

Asp Ala Val Val Thr Gln Glu Ser Ala Leu Thr Ser Ser Pro Gly Glu 
1               5                   10                  15      


Thr Val Thr Leu Thr Cys Arg Ser Ser Thr Gly Ala Val Thr Thr Ser 
            20                  25                  30          


Asn Tyr Ala Ser Trp Val Gln Glu Lys Pro Asp His Leu Phe Thr Gly 
        35                  40                  45              


Leu Ile Gly Gly Thr Asn Asn Arg Ala Pro Gly Val Pro Ala Arg Phe 
    50                  55                  60                  


Ser Gly Ser Leu Ile Gly Asp Lys Ala Ala Leu Thr Ile Thr Gly Ala 
65                  70                  75                  80  


Gln Thr Glu Asp Glu Ala Ile Tyr Phe Cys Val Leu Trp Tyr Ser Asp 
                85                  90                  95      


His Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Gly Gly 
            100                 105                 110         


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Asp Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Ala Pro 
    130                 135                 140                 


Ser Gln Ser Leu Ser Ile Thr Cys Thr Val Ser Gly Phe Leu Leu Thr 
145                 150                 155                 160 


Asp Tyr Gly Val Asn Trp Val Arg Gln Ser Pro Gly Lys Gly Leu Glu 
                165                 170                 175     


Trp Leu Gly Val Ile Trp Gly Asp Gly Ile Thr Asp Tyr Asn Ser Ala 
            180                 185                 190         


Leu Lys Ser Arg Leu Ser Val Thr Lys Asp Asn Ser Lys Ser Gln Val 
        195                 200                 205             


Phe Leu Lys Met Asn Ser Leu Gln Ser Gly Asp Ser Ala Arg Tyr Tyr 
    210                 215                 220                 


Cys Val Thr Gly Leu Phe Asp Tyr Trp Gly Gln Gly Thr Thr Leu Thr 
225                 230                 235                 240 


Val Ser Ser Glu Ser Lys Tyr Gly Pro Pro Cys Pro Pro Cys Pro Ile 
                245                 250                 255     


Tyr Ile Trp Ala Pro Leu Ala Gly Ile Cys Val Ala Leu Leu Leu Ser 
            260                 265                 270         


Leu Ile Ile Thr Leu Ile Cys Asn Ser Arg Arg Asn Arg Gly Gly Gln 
        275                 280                 285             


Ser Asp Tyr Met Asn Met Thr Pro Arg Arg Pro Gly Leu Thr Arg Lys 
    290                 295                 300                 


Pro Tyr Gln Pro Tyr Ala Pro Ala Arg Asp Phe Ala Ala Tyr Arg Pro 
305                 310                 315                 320 


Lys Trp Ile Arg Lys Lys Phe Pro His Ile Phe Lys Gln Pro Phe Lys 
                325                 330                 335     


Lys Thr Thr Gly Ala Ala Gln Glu Glu Asp Ala Cys Ser Cys Arg Cys 
            340                 345                 350         


Pro Gln Glu Glu Glu Gly Gly Gly Gly Gly Tyr Glu Leu Arg Ala Lys 
        355                 360                 365             


Phe Ser Arg Ser Ala Glu Thr Ala Ala Asn Leu Gln Asp Pro Asn Gln 
    370                 375                 380                 


Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu 
385                 390                 395                 400 


Glu Lys Lys Arg Ala Arg Asp Pro Glu Met Gly Gly Lys Gln Gln Arg 
                405                 410                 415     


Arg Arg Asn Pro Gln Glu Gly Val Tyr Asn Ala Leu Gln Lys Asp Lys 
            420                 425                 430         


Met Ala Glu Ala Tyr Ser Glu Ile Gly Thr Lys Gly Glu Arg Arg Arg 
        435                 440                 445             


Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys 
    450                 455                 460                 


Asp Thr Tyr Asp Ala Leu His Met Gln Thr Leu Ala Pro Arg 
465                 470                 475             


<210>  290
<211>  243
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - Humanized scFv fragments

<400>  290

Asp Ala Val Val Thr Gln Glu Ser Ala Leu Thr Ser Ser Pro Gly Glu 
1               5                   10                  15      


Thr Val Thr Leu Thr Cys Arg Ser Ser Thr Gly Ala Val Thr Thr Ser 
            20                  25                  30          


Asn Tyr Ala Ser Trp Val Gln Glu Lys Pro Asp His Leu Phe Thr Gly 
        35                  40                  45              


Leu Ile Gly Gly Thr Asn Asn Arg Ala Pro Gly Val Pro Ala Arg Phe 
    50                  55                  60                  


Ser Gly Ser Leu Ile Gly Asp Lys Ala Ala Leu Thr Ile Thr Gly Ala 
65                  70                  75                  80  


Gln Thr Glu Asp Glu Ala Ile Tyr Phe Cys Val Leu Trp Tyr Ser Asp 
                85                  90                  95      


His Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Gly Gly 
            100                 105                 110         


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Asp Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Ala Pro 
    130                 135                 140                 


Ser Gln Ser Leu Ser Ile Thr Cys Thr Val Ser Gly Phe Leu Leu Thr 
145                 150                 155                 160 


Asp Tyr Gly Val Asn Trp Val Arg Gln Ser Pro Gly Lys Gly Leu Glu 
                165                 170                 175     


Trp Leu Gly Val Ile Trp Gly Asp Gly Ile Thr Asp Tyr Asn Ser Ala 
            180                 185                 190         


Leu Lys Ser Arg Leu Ser Val Thr Lys Asp Asn Ser Lys Ser Gln Val 
        195                 200                 205             


Phe Leu Lys Met Asn Ser Leu Gln Ser Gly Asp Ser Ala Arg Tyr Tyr 
    210                 215                 220                 


Cys Val Thr Gly Leu Phe Asp Tyr Trp Gly Gln Gly Thr Thr Leu Thr 
225                 230                 235                 240 


Val Ser Ser 
            


<210>  291
<211>  243
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - Humanized scFv fragments

<400>  291

Gln Ala Val Val Thr Gln Glu Pro Ser Leu Thr Val Ser Pro Gly Gly 
1               5                   10                  15      


Thr Val Thr Leu Thr Cys Arg Ser Ser Thr Gly Ala Val Thr Thr Ser 
            20                  25                  30          


Asn Tyr Ala Ser Trp Phe Gln Gln Lys Pro Gly Gln Ala Pro Arg Thr 
        35                  40                  45              


Leu Ile Tyr Gly Thr Asn Asn Arg Ala Pro Trp Thr Pro Ala Arg Phe 
    50                  55                  60                  


Ser Gly Ser Leu Leu Gly Gly Lys Ala Ala Leu Thr Leu Ser Gly Ala 
65                  70                  75                  80  


Gln Pro Glu Asp Glu Ala Glu Tyr Tyr Cys Val Leu Trp Tyr Ser Asp 
                85                  90                  95      


His Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Gly Gly 
            100                 105                 110         


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro 
    130                 135                 140                 


Ser Glu Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Phe Leu Leu Thr 
145                 150                 155                 160 


Asp Tyr Gly Val Asn Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu 
                165                 170                 175     


Trp Ile Gly Val Ile Trp Gly Asp Gly Ile Thr Asp Tyr Asn Pro Ser 
            180                 185                 190         


Leu Lys Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe 
        195                 200                 205             


Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr 
    210                 215                 220                 


Cys Ala Arg Gly Leu Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr 
225                 230                 235                 240 


Val Ser Ser 
            


<210>  292
<211>  243
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - Humanized scFv fragments

<400>  292

Gln Ala Val Val Thr Gln Glu Pro Ser Leu Thr Val Ser Pro Gly Gly 
1               5                   10                  15      


Thr Val Thr Leu Thr Cys Gly Ser Ser Thr Gly Ala Val Thr Thr Ser 
            20                  25                  30          


Asn Tyr Ala Ser Trp Val Gln Gln Lys Pro Gly Gln Ala Pro Arg Gly 
        35                  40                  45              


Leu Ile Gly Gly Thr Asn Asn Arg Ala Pro Gly Val Pro Ala Arg Phe 
    50                  55                  60                  


Ser Gly Ser Leu Leu Gly Gly Lys Ala Ala Leu Thr Ile Ser Gly Ala 
65                  70                  75                  80  


Gln Pro Glu Asp Glu Ala Glu Tyr Tyr Cys Val Leu Trp Tyr Ser Asp 
                85                  90                  95      


His Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Gly Gly 
            100                 105                 110         


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro 
    130                 135                 140                 


Ser Glu Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Phe Leu Leu Thr 
145                 150                 155                 160 


Asp Tyr Gly Val Asn Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu 
                165                 170                 175     


Trp Ile Gly Val Ile Trp Gly Asp Gly Ile Thr Asp Tyr Asn Pro Ser 
            180                 185                 190         


Leu Lys Ser Arg Val Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Phe 
        195                 200                 205             


Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr 
    210                 215                 220                 


Cys Val Thr Gly Leu Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr 
225                 230                 235                 240 


Val Ser Ser 
            


<210>  293
<211>  243
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - Humanized scFv fragments

<400>  293

Gln Ala Val Val Thr Gln Glu Pro Ser Leu Thr Val Ser Pro Gly Gly 
1               5                   10                  15      


Thr Val Thr Leu Thr Cys Gly Ser Ser Thr Gly Ala Val Thr Thr Ser 
            20                  25                  30          


Asn Tyr Ala Ser Trp Val Gln Gln Lys Pro Gly Gln Ala Pro Arg Gly 
        35                  40                  45              


Leu Ile Gly Gly Thr Asn Asn Arg Ala Pro Gly Val Pro Ala Arg Phe 
    50                  55                  60                  


Ser Gly Ser Leu Leu Gly Gly Lys Ala Ala Leu Thr Ile Ser Gly Ala 
65                  70                  75                  80  


Gln Pro Glu Asp Glu Ala Glu Tyr Tyr Cys Val Leu Trp Tyr Ser Asp 
                85                  90                  95      


His Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Gly Gly 
            100                 105                 110         


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro 
    130                 135                 140                 


Ser Glu Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Phe Leu Leu Thr 
145                 150                 155                 160 


Asp Tyr Gly Val Asn Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu 
                165                 170                 175     


Trp Ile Gly Val Ile Trp Gly Asp Gly Ile Thr Asp Tyr Asn Pro Ser 
            180                 185                 190         


Leu Lys Ser Arg Val Thr Ile Ser Lys Asp Asn Ser Lys Asn Gln Phe 
        195                 200                 205             


Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr 
    210                 215                 220                 


Cys Val Thr Gly Leu Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr 
225                 230                 235                 240 


Val Ser Ser 
            


<210>  294
<211>  243
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - Humanized scFv fragments

<400>  294

Gln Ala Val Val Thr Gln Glu Pro Ser Leu Thr Val Ser Pro Gly Gly 
1               5                   10                  15      


Thr Val Thr Leu Thr Cys Gly Ser Ser Thr Gly Ala Val Thr Thr Ser 
            20                  25                  30          


Asn Tyr Ala Ser Trp Val Gln Gln Lys Pro Gly Gln Ala Pro Arg Gly 
        35                  40                  45              


Leu Ile Gly Gly Thr Asn Asn Arg Ala Pro Gly Val Pro Ala Arg Phe 
    50                  55                  60                  


Ser Gly Ser Leu Leu Gly Gly Lys Ala Ala Leu Thr Ile Ser Gly Ala 
65                  70                  75                  80  


Gln Pro Glu Asp Glu Ala Glu Tyr Tyr Cys Val Leu Trp Tyr Ser Asp 
                85                  90                  95      


His Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Gly Gly 
            100                 105                 110         


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro 
    130                 135                 140                 


Ser Glu Thr Leu Ser Ile Thr Cys Thr Val Ser Gly Phe Leu Leu Thr 
145                 150                 155                 160 


Asp Tyr Gly Val Asn Trp Val Arg Gln Pro Pro Gly Lys Gly Leu Glu 
                165                 170                 175     


Trp Leu Gly Val Ile Trp Gly Asp Gly Ile Thr Asp Tyr Asn Pro Ser 
            180                 185                 190         


Leu Lys Ser Arg Leu Thr Val Ser Lys Asp Thr Ser Lys Asn Gln Val 
        195                 200                 205             


Ser Leu Lys Met Ser Ser Leu Thr Ala Ala Asp Thr Ala Val Tyr Tyr 
    210                 215                 220                 


Cys Val Thr Gly Leu Phe Asp Tyr Trp Gly Gln Gly Thr Leu Leu Thr 
225                 230                 235                 240 


Val Ser Ser 
            


<210>  295
<211>  243
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - Humanized scFv fragments

<400>  295

Gln Ala Val Val Thr Gln Glu Pro Ser Leu Thr Val Ser Pro Gly Gly 
1               5                   10                  15      


Thr Val Thr Leu Thr Cys Gly Ser Ser Thr Gly Ala Val Thr Thr Ser 
            20                  25                  30          


Asn Tyr Ala Ser Trp Val Gln Gln Lys Pro Gly Gln Ala Pro Arg Gly 
        35                  40                  45              


Leu Ile Gly Gly Thr Asn Asn Arg Ala Pro Gly Val Pro Ala Arg Phe 
    50                  55                  60                  


Ser Gly Ser Leu Leu Gly Gly Lys Ala Ala Leu Thr Ile Ser Gly Ala 
65                  70                  75                  80  


Gln Pro Glu Asp Glu Ala Glu Tyr Tyr Cys Val Leu Trp Tyr Ser Asp 
                85                  90                  95      


His Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Gly Gly 
            100                 105                 110         


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro 
    130                 135                 140                 


Ser Glu Thr Leu Ser Ile Thr Cys Thr Val Ser Gly Phe Leu Leu Thr 
145                 150                 155                 160 


Asp Tyr Gly Val Asn Trp Val Arg Gln Pro Pro Gly Lys Gly Leu Glu 
                165                 170                 175     


Trp Leu Gly Val Ile Trp Gly Asp Gly Ile Thr Asp Tyr Asn Pro Ser 
            180                 185                 190         


Leu Lys Ser Arg Leu Thr Val Ser Lys Asp Asn Ser Lys Asn Gln Val 
        195                 200                 205             


Ser Leu Lys Met Ser Ser Leu Thr Ala Ala Asp Thr Ala Val Tyr Tyr 
    210                 215                 220                 


Cys Val Thr Gly Leu Phe Asp Tyr Trp Gly Gln Gly Thr Leu Leu Thr 
225                 230                 235                 240 


Val Ser Ser 
            


<210>  296
<211>  243
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - Humanized scFv fragments

<400>  296

Gln Ala Val Val Thr Gln Glu Pro Ser Leu Thr Val Ser Pro Gly Gly 
1               5                   10                  15      


Thr Val Thr Leu Thr Cys Gly Ser Ser Thr Gly Ala Val Thr Thr Ser 
            20                  25                  30          


Asn Tyr Ala Ser Trp Val Gln Gln Lys Pro Gly Gln Ala Pro Arg Gly 
        35                  40                  45              


Leu Ile Gly Gly Thr Asn Asn Arg Ala Pro Gly Val Pro Ala Arg Phe 
    50                  55                  60                  


Ser Gly Ser Leu Leu Gly Gly Lys Ala Ala Leu Thr Ile Ser Gly Ala 
65                  70                  75                  80  


Gln Pro Glu Asp Glu Ala Glu Tyr Tyr Cys Val Leu Trp Tyr Ser Asp 
                85                  90                  95      


His Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Gly Gly 
            100                 105                 110         


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro 
    130                 135                 140                 


Ser Glu Thr Leu Ser Ile Thr Cys Thr Val Ser Gly Phe Leu Leu Thr 
145                 150                 155                 160 


Asp Tyr Gly Val Asn Trp Val Arg Gln Pro Pro Gly Lys Gly Leu Glu 
                165                 170                 175     


Trp Leu Gly Val Ile Trp Gly Asp Gly Ile Thr Asp Tyr Asn Pro Ser 
            180                 185                 190         


Leu Lys Ser Arg Leu Thr Val Ser Lys Asp Thr Ser Lys Asn Gln Val 
        195                 200                 205             


Ser Leu Lys Met Ser Ser Leu Thr Ala Ala Asp Thr Ala Arg Tyr Tyr 
    210                 215                 220                 


Cys Val Thr Gly Leu Phe Asp Tyr Trp Gly Gln Gly Thr Thr Leu Thr 
225                 230                 235                 240 


Val Ser Ser 
            


<210>  297
<211>  243
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - Humanized scFv fragments

<400>  297

Gln Ala Val Val Thr Gln Glu Pro Ser Leu Thr Val Ser Pro Gly Gly 
1               5                   10                  15      


Thr Val Thr Leu Thr Cys Gly Ser Ser Thr Gly Ala Val Thr Thr Ser 
            20                  25                  30          


Asn Tyr Ala Ser Trp Val Gln Gln Lys Pro Gly Gln Ala Pro Arg Gly 
        35                  40                  45              


Leu Ile Gly Gly Thr Asn Asn Arg Ala Pro Gly Val Pro Ala Arg Phe 
    50                  55                  60                  


Ser Gly Ser Leu Leu Gly Gly Lys Ala Ala Leu Thr Ile Ser Gly Ala 
65                  70                  75                  80  


Gln Pro Glu Asp Glu Ala Glu Tyr Tyr Cys Val Leu Trp Tyr Ser Asp 
                85                  90                  95      


His Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Gly Gly 
            100                 105                 110         


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro 
    130                 135                 140                 


Ser Glu Thr Leu Ser Ile Thr Cys Thr Val Ser Gly Phe Leu Leu Thr 
145                 150                 155                 160 


Asp Tyr Gly Val Asn Trp Val Arg Gln Pro Pro Gly Lys Gly Leu Glu 
                165                 170                 175     


Trp Leu Gly Val Ile Trp Gly Asp Gly Ile Thr Asp Tyr Asn Pro Ser 
            180                 185                 190         


Leu Lys Ser Arg Leu Thr Val Ser Lys Asp Thr Ser Lys Asn Gln Val 
        195                 200                 205             


Ser Leu Lys Met Ser Ser Leu Thr Asp Ala Asp Thr Ala Arg Tyr Tyr 
    210                 215                 220                 


Cys Val Thr Gly Leu Phe Asp Tyr Trp Gly Gln Gly Thr Thr Leu Thr 
225                 230                 235                 240 


Val Ser Ser 
            


<210>  298
<211>  243
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - Humanized scFv fragments

<400>  298

Gln Ala Val Val Thr Gln Glu Pro Ser Leu Thr Val Ser Pro Gly Gly 
1               5                   10                  15      


Thr Val Thr Leu Thr Cys Gly Ser Ser Thr Gly Ala Val Thr Thr Ser 
            20                  25                  30          


Asn Tyr Ala Ser Trp Val Gln Gln Lys Pro Gly Gln Ala Pro Arg Gly 
        35                  40                  45              


Leu Ile Gly Gly Thr Asn Asn Arg Ala Pro Gly Val Pro Ala Arg Phe 
    50                  55                  60                  


Ser Gly Ser Leu Leu Gly Gly Lys Ala Ala Leu Thr Ile Ser Gly Ala 
65                  70                  75                  80  


Gln Pro Glu Asp Glu Ala Glu Tyr Tyr Cys Val Leu Trp Tyr Ser Asp 
                85                  90                  95      


His Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Gly Gly 
            100                 105                 110         


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Gln Val Gln Leu Gln Gln Ser Gly Pro Gly Leu Val Lys Pro 
    130                 135                 140                 


Ser Glu Thr Leu Ser Ile Thr Cys Thr Val Ser Gly Phe Leu Leu Thr 
145                 150                 155                 160 


Asp Tyr Gly Val Asn Trp Val Arg Gln Pro Pro Gly Lys Gly Leu Glu 
                165                 170                 175     


Trp Leu Gly Val Ile Trp Gly Asp Gly Ile Thr Asp Tyr Asn Pro Ser 
            180                 185                 190         


Leu Lys Ser Arg Leu Thr Val Ser Lys Asp Asn Ser Lys Asn Gln Val 
        195                 200                 205             


Ser Leu Lys Met Ser Ser Leu Thr Ala Ala Asp Thr Ala Val Tyr Tyr 
    210                 215                 220                 


Cys Val Thr Gly Leu Phe Asp Tyr Trp Gly Gln Gly Thr Leu Leu Thr 
225                 230                 235                 240 


Val Ser Ser 
            


<210>  299
<211>  243
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - Humanized scFv fragments

<400>  299

Gln Ala Val Val Thr Gln Glu Pro Ser Leu Thr Val Ser Pro Gly Gly 
1               5                   10                  15      


Thr Val Thr Leu Thr Cys Gly Ser Ser Thr Gly Ala Val Thr Thr Ser 
            20                  25                  30          


Asn Tyr Ala Ser Trp Val Gln Gln Lys Pro Gly Gln Ala Pro Arg Gly 
        35                  40                  45              


Leu Ile Gly Gly Thr Asn Asn Arg Ala Pro Gly Val Pro Ala Arg Phe 
    50                  55                  60                  


Ser Gly Ser Leu Leu Gly Gly Lys Ala Ala Leu Thr Ile Ser Gly Ala 
65                  70                  75                  80  


Gln Pro Glu Asp Glu Ala Glu Tyr Tyr Cys Val Leu Trp Tyr Ser Asp 
                85                  90                  95      


His Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Gly Gly 
            100                 105                 110         


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Gln Val Gln Leu Gln Gln Ser Gly Pro Gly Leu Val Lys Pro 
    130                 135                 140                 


Ser Glu Thr Leu Ser Ile Thr Cys Thr Val Ser Gly Phe Ser Leu Thr 
145                 150                 155                 160 


Asp Tyr Gly Val Asn Trp Val Arg Gln Pro Pro Gly Lys Gly Leu Glu 
                165                 170                 175     


Trp Leu Gly Val Ile Trp Gly Asp Gly Ser Thr Asp Tyr Asn Pro Ser 
            180                 185                 190         


Leu Lys Ser Arg Leu Thr Val Ser Lys Asp Asn Ser Lys Asn Gln Val 
        195                 200                 205             


Ser Leu Lys Met Ser Ser Leu Thr Ala Ala Asp Thr Ala Val Tyr Tyr 
    210                 215                 220                 


Cys Val Thr Gly Leu Phe Asp Tyr Trp Gly Gln Gly Thr Leu Leu Thr 
225                 230                 235                 240 


Val Ser Ser 
            


<210>  300
<211>  243
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - Humanized scFv fragments

<400>  300

Gln Ala Val Val Thr Gln Glu Pro Ser Leu Thr Val Ser Pro Gly Gly 
1               5                   10                  15      


Thr Val Thr Leu Thr Cys Arg Ser Ser Thr Gly Ala Val Thr Thr Ser 
            20                  25                  30          


Asn Tyr Ala Ser Trp Val Gln Gln Lys Pro Gly Gln Ala Pro Arg Gly 
        35                  40                  45              


Leu Ile Gly Gly Thr Asn Asn Arg Ala Pro Gly Val Pro Ala Arg Phe 
    50                  55                  60                  


Ser Gly Ser Leu Leu Gly Gly Lys Ala Ala Leu Thr Ile Ser Gly Ala 
65                  70                  75                  80  


Gln Pro Glu Asp Glu Ala Glu Tyr Tyr Cys Val Leu Trp Tyr Ser Asp 
                85                  90                  95      


His Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Gly Gly 
            100                 105                 110         


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro 
    130                 135                 140                 


Ser Glu Thr Leu Ser Ile Thr Cys Thr Val Ser Gly Phe Leu Leu Thr 
145                 150                 155                 160 


Asp Tyr Gly Val Asn Trp Val Arg Gln Pro Pro Gly Lys Gly Leu Glu 
                165                 170                 175     


Trp Leu Gly Val Ile Trp Gly Asp Gly Ile Thr Asp Tyr Asn Pro Ser 
            180                 185                 190         


Leu Lys Ser Arg Leu Thr Val Ser Lys Asp Asn Ser Lys Asn Gln Val 
        195                 200                 205             


Ser Leu Lys Met Ser Ser Leu Thr Ala Ala Asp Thr Ala Val Tyr Tyr 
    210                 215                 220                 


Cys Val Thr Gly Leu Phe Asp Tyr Trp Gly Gln Gly Thr Leu Leu Thr 
225                 230                 235                 240 


Val Ser Ser 
            


<210>  301
<211>  243
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - Humanized scFv fragments

<400>  301

Gln Ala Val Val Thr Gln Glu Pro Ser Leu Thr Val Ser Pro Gly Gly 
1               5                   10                  15      


Thr Val Thr Leu Thr Cys Arg Ser Ser Thr Gly Ala Val Thr Thr Ser 
            20                  25                  30          


Asn Tyr Ala Ser Trp Val Gln Gln Lys Pro Gly Gln Ala Pro Arg Gly 
        35                  40                  45              


Leu Ile Gly Gly Thr Asn Asn Arg Ala Pro Gly Val Pro Ala Arg Phe 
    50                  55                  60                  


Ser Gly Ser Leu Leu Gly Gly Lys Ala Ala Leu Thr Ile Ser Gly Ala 
65                  70                  75                  80  


Gln Pro Glu Asp Glu Ala Glu Tyr Tyr Cys Val Leu Trp Tyr Ser Asp 
                85                  90                  95      


His Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Gly Gly 
            100                 105                 110         


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Gln Val Gln Leu Gln Gln Ser Gly Pro Gly Leu Val Lys Pro 
    130                 135                 140                 


Ser Glu Thr Leu Ser Ile Thr Cys Thr Val Ser Gly Phe Leu Leu Thr 
145                 150                 155                 160 


Asp Tyr Gly Val Asn Trp Val Arg Gln Pro Pro Gly Lys Gly Leu Glu 
                165                 170                 175     


Trp Leu Gly Val Ile Trp Gly Asp Gly Ile Thr Asp Tyr Asn Pro Ser 
            180                 185                 190         


Leu Lys Ser Arg Leu Thr Val Ser Lys Asp Asn Ser Lys Asn Gln Val 
        195                 200                 205             


Ser Leu Lys Met Ser Ser Leu Thr Ala Ala Asp Thr Ala Val Tyr Tyr 
    210                 215                 220                 


Cys Val Thr Gly Leu Phe Asp Tyr Trp Gly Gln Gly Thr Leu Leu Thr 
225                 230                 235                 240 


Val Ser Ser 
            


<210>  302
<211>  243
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - Humanized scFv fragments

<400>  302

Gln Ala Val Val Thr Gln Glu Pro Ser Leu Thr Val Ser Pro Gly Gly 
1               5                   10                  15      


Thr Val Thr Leu Thr Cys Arg Ser Ser Thr Gly Ala Val Thr Thr Ser 
            20                  25                  30          


Asn Tyr Ala Ser Trp Val Gln Gln Lys Pro Gly Gln Ala Pro Arg Gly 
        35                  40                  45              


Leu Ile Gly Gly Thr Asn Asn Arg Ala Pro Gly Val Pro Ala Arg Phe 
    50                  55                  60                  


Ser Gly Ser Leu Leu Gly Gly Lys Ala Ala Leu Thr Ile Ser Gly Ala 
65                  70                  75                  80  


Gln Pro Glu Asp Glu Ala Glu Tyr Tyr Cys Val Leu Trp Tyr Ser Asp 
                85                  90                  95      


His Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Gly Gly 
            100                 105                 110         


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Gln Val Gln Leu Gln Gln Ser Gly Pro Gly Leu Val Lys Pro 
    130                 135                 140                 


Ser Glu Thr Leu Ser Ile Thr Cys Thr Val Ser Gly Phe Ser Leu Thr 
145                 150                 155                 160 


Asp Tyr Gly Val Asn Trp Val Arg Gln Pro Pro Gly Lys Gly Leu Glu 
                165                 170                 175     


Trp Leu Gly Val Ile Trp Gly Asp Gly Ser Thr Asp Tyr Asn Pro Ser 
            180                 185                 190         


Leu Lys Ser Arg Leu Thr Val Ser Lys Asp Asn Ser Lys Asn Gln Val 
        195                 200                 205             


Ser Leu Lys Met Ser Ser Leu Thr Ala Ala Asp Thr Ala Val Tyr Tyr 
    210                 215                 220                 


Cys Val Thr Gly Leu Phe Asp Tyr Trp Gly Gln Gly Thr Leu Leu Thr 
225                 230                 235                 240 


Val Ser Ser 
            


<210>  303
<211>  243
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - Humanized scFv fragments

<400>  303

Gln Ala Val Val Thr Gln Glu Pro Ser Leu Thr Val Ser Pro Gly Gly 
1               5                   10                  15      


Thr Val Thr Leu Thr Cys Gly Ser Ser Thr Gly Ala Val Thr Thr Ser 
            20                  25                  30          


Asn Tyr Ala Ser Trp Val Gln Gln Lys Pro Gly Gln Ala Phe Arg Gly 
        35                  40                  45              


Leu Ile Gly Gly Thr Asn Asn Arg Ala Pro Gly Val Pro Ala Arg Phe 
    50                  55                  60                  


Ser Gly Ser Leu Leu Gly Gly Lys Ala Ala Leu Thr Ile Ser Gly Ala 
65                  70                  75                  80  


Gln Pro Glu Asp Glu Ala Glu Tyr Tyr Cys Val Leu Trp Tyr Ser Asp 
                85                  90                  95      


His Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Gly Gly 
            100                 105                 110         


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro 
    130                 135                 140                 


Ser Glu Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Phe Leu Leu Thr 
145                 150                 155                 160 


Asp Tyr Gly Val Asn Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu 
                165                 170                 175     


Trp Ile Gly Val Ile Trp Gly Asp Gly Ile Thr Asp Tyr Asn Pro Ser 
            180                 185                 190         


Leu Lys Ser Arg Val Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Phe 
        195                 200                 205             


Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr 
    210                 215                 220                 


Cys Val Thr Gly Leu Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr 
225                 230                 235                 240 


Val Ser Ser 
            


<210>  304
<211>  243
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - Humanized scFv fragments

<400>  304

Gln Ala Val Val Thr Gln Glu Pro Ser Leu Thr Val Ser Pro Gly Gly 
1               5                   10                  15      


Thr Val Thr Leu Thr Cys Gly Ser Ser Thr Gly Ala Val Thr Thr Ser 
            20                  25                  30          


Asn Tyr Ala Ser Trp Val Gln Gln Lys Pro Gly Gln Ala Phe Arg Gly 
        35                  40                  45              


Leu Ile Gly Gly Thr Asn Asn Arg Ala Pro Gly Val Pro Ala Arg Phe 
    50                  55                  60                  


Ser Gly Ser Leu Leu Gly Gly Lys Ala Ala Leu Thr Ile Ser Gly Ala 
65                  70                  75                  80  


Gln Pro Glu Asp Glu Ala Glu Tyr Tyr Cys Val Leu Trp Tyr Ser Asp 
                85                  90                  95      


His Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Gly Gly 
            100                 105                 110         


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro 
    130                 135                 140                 


Ser Glu Thr Leu Ser Ile Thr Cys Thr Val Ser Gly Phe Leu Leu Thr 
145                 150                 155                 160 


Asp Tyr Gly Val Asn Trp Val Arg Gln Pro Pro Gly Lys Gly Leu Glu 
                165                 170                 175     


Trp Leu Gly Val Ile Trp Gly Asp Gly Ile Thr Asp Tyr Asn Pro Ser 
            180                 185                 190         


Leu Lys Ser Arg Leu Thr Val Ser Lys Asp Thr Ser Lys Asn Gln Val 
        195                 200                 205             


Ser Leu Lys Met Ser Ser Leu Thr Ala Ala Asp Thr Ala Val Tyr Tyr 
    210                 215                 220                 


Cys Val Thr Gly Leu Phe Asp Tyr Trp Gly Gln Gly Thr Leu Leu Thr 
225                 230                 235                 240 


Val Ser Ser 
            


<210>  305
<211>  243
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - Humanized scFv fragments

<400>  305

Gln Ala Val Val Thr Gln Glu Pro Ser Leu Thr Val Ser Pro Gly Gly 
1               5                   10                  15      


Thr Val Thr Leu Thr Cys Gly Ser Ser Thr Gly Ala Val Thr Thr Ser 
            20                  25                  30          


Asn Tyr Ala Ser Trp Val Gln Gln Lys Pro Gly Gln Ala Phe Arg Gly 
        35                  40                  45              


Leu Ile Gly Gly Thr Asn Asn Arg Ala Pro Gly Val Pro Ala Arg Phe 
    50                  55                  60                  


Ser Gly Ser Leu Leu Gly Gly Lys Ala Ala Leu Thr Ile Ser Gly Ala 
65                  70                  75                  80  


Gln Pro Glu Asp Glu Ala Glu Tyr Tyr Cys Val Leu Trp Tyr Ser Asp 
                85                  90                  95      


His Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Gly Gly 
            100                 105                 110         


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro 
    130                 135                 140                 


Ser Glu Thr Leu Ser Ile Thr Cys Thr Val Ser Gly Phe Leu Leu Thr 
145                 150                 155                 160 


Asp Tyr Gly Val Asn Trp Val Arg Gln Pro Pro Gly Lys Gly Leu Glu 
                165                 170                 175     


Trp Leu Gly Val Ile Trp Gly Asp Gly Ile Thr Asp Tyr Asn Pro Ser 
            180                 185                 190         


Leu Lys Ser Arg Leu Thr Val Ser Lys Asp Thr Ser Lys Asn Gln Val 
        195                 200                 205             


Ser Leu Lys Met Ser Ser Leu Thr Asp Ala Asp Thr Ala Arg Tyr Tyr 
    210                 215                 220                 


Cys Val Thr Gly Leu Phe Asp Tyr Trp Gly Gln Gly Thr Thr Leu Thr 
225                 230                 235                 240 


Val Ser Ser 
            


<210>  306
<211>  243
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - Humanized scFv fragments

<400>  306

Gln Ala Val Val Thr Gln Glu Pro Ser Leu Thr Val Ser Pro Gly Gly 
1               5                   10                  15      


Thr Val Thr Leu Thr Cys Gly Ser Ser Thr Gly Ala Val Thr Thr Ser 
            20                  25                  30          


Asn Tyr Ala Ser Trp Val Gln Gln Lys Pro Asp His Leu Phe Arg Gly 
        35                  40                  45              


Leu Ile Gly Gly Thr Asn Asn Arg Ala Pro Gly Val Pro Ala Arg Phe 
    50                  55                  60                  


Ser Gly Ser Leu Leu Gly Gly Lys Ala Ala Leu Thr Ile Ser Gly Ala 
65                  70                  75                  80  


Gln Pro Glu Asp Glu Ala Glu Tyr Tyr Cys Val Leu Trp Tyr Ser Asp 
                85                  90                  95      


His Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Gly Gly 
            100                 105                 110         


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro 
    130                 135                 140                 


Ser Glu Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Phe Leu Leu Thr 
145                 150                 155                 160 


Asp Tyr Gly Val Asn Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu 
                165                 170                 175     


Trp Ile Gly Val Ile Trp Gly Asp Gly Ile Thr Asp Tyr Asn Pro Ser 
            180                 185                 190         


Leu Lys Ser Arg Val Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Phe 
        195                 200                 205             


Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr 
    210                 215                 220                 


Cys Val Thr Gly Leu Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr 
225                 230                 235                 240 


Val Ser Ser 
            


<210>  307
<211>  243
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - Humanized scFv fragments

<400>  307

Gln Ala Val Val Thr Gln Glu Pro Ser Leu Thr Val Ser Pro Gly Gly 
1               5                   10                  15      


Thr Val Thr Leu Thr Cys Gly Ser Ser Thr Gly Ala Val Thr Thr Ser 
            20                  25                  30          


Asn Tyr Ala Ser Trp Val Gln Gln Lys Pro Asp His Leu Phe Arg Gly 
        35                  40                  45              


Leu Ile Gly Gly Thr Asn Asn Arg Ala Pro Gly Val Pro Ala Arg Phe 
    50                  55                  60                  


Ser Gly Ser Leu Leu Gly Gly Lys Ala Ala Leu Thr Ile Ser Gly Ala 
65                  70                  75                  80  


Gln Pro Glu Asp Glu Ala Glu Tyr Tyr Cys Val Leu Trp Tyr Ser Asp 
                85                  90                  95      


His Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Gly Gly 
            100                 105                 110         


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro 
    130                 135                 140                 


Ser Glu Thr Leu Ser Ile Thr Cys Thr Val Ser Gly Phe Leu Leu Thr 
145                 150                 155                 160 


Asp Tyr Gly Val Asn Trp Val Arg Gln Pro Pro Gly Lys Gly Leu Glu 
                165                 170                 175     


Trp Leu Gly Val Ile Trp Gly Asp Gly Ile Thr Asp Tyr Asn Pro Ser 
            180                 185                 190         


Leu Lys Ser Arg Leu Thr Val Ser Lys Asp Thr Ser Lys Asn Gln Val 
        195                 200                 205             


Ser Leu Lys Met Ser Ser Leu Thr Ala Ala Asp Thr Ala Val Tyr Tyr 
    210                 215                 220                 


Cys Val Thr Gly Leu Phe Asp Tyr Trp Gly Gln Gly Thr Leu Leu Thr 
225                 230                 235                 240 


Val Ser Ser 
            


<210>  308
<211>  243
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - Humanized scFv fragments

<400>  308

Gln Ala Val Val Thr Gln Glu Pro Ser Leu Thr Val Ser Pro Gly Gly 
1               5                   10                  15      


Thr Val Thr Leu Thr Cys Gly Ser Ser Thr Gly Ala Val Thr Thr Ser 
            20                  25                  30          


Asn Tyr Ala Ser Trp Val Gln Gln Lys Pro Asp His Leu Phe Arg Gly 
        35                  40                  45              


Leu Ile Gly Gly Thr Asn Asn Arg Ala Pro Gly Val Pro Ala Arg Phe 
    50                  55                  60                  


Ser Gly Ser Leu Leu Gly Gly Lys Ala Ala Leu Thr Ile Ser Gly Ala 
65                  70                  75                  80  


Gln Pro Glu Asp Glu Ala Glu Tyr Tyr Cys Val Leu Trp Tyr Ser Asp 
                85                  90                  95      


His Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Gly Gly 
            100                 105                 110         


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro 
    130                 135                 140                 


Ser Glu Thr Leu Ser Ile Thr Cys Thr Val Ser Gly Phe Leu Leu Thr 
145                 150                 155                 160 


Asp Tyr Gly Val Asn Trp Val Arg Gln Pro Pro Gly Lys Gly Leu Glu 
                165                 170                 175     


Trp Leu Gly Val Ile Trp Gly Asp Gly Ile Thr Asp Tyr Asn Pro Ser 
            180                 185                 190         


Leu Lys Ser Arg Leu Thr Val Ser Lys Asp Thr Ser Lys Asn Gln Val 
        195                 200                 205             


Ser Leu Lys Met Ser Ser Leu Thr Ala Ala Asp Thr Ala Arg Tyr Tyr 
    210                 215                 220                 


Cys Val Thr Gly Leu Phe Asp Tyr Trp Gly Gln Gly Thr Thr Leu Thr 
225                 230                 235                 240 


Val Ser Ser 
            


<210>  309
<211>  243
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - Humanized scFv fragments

<400>  309

Gln Ala Val Val Thr Gln Glu Pro Ser Leu Thr Val Ser Pro Gly Gly 
1               5                   10                  15      


Thr Val Thr Leu Thr Cys Gly Ser Ser Thr Gly Ala Val Thr Thr Ser 
            20                  25                  30          


Asn Tyr Ala Ser Trp Val Gln Gln Lys Pro Asp His Leu Phe Arg Gly 
        35                  40                  45              


Leu Ile Gly Gly Thr Asn Asn Arg Ala Pro Gly Val Pro Ala Arg Phe 
    50                  55                  60                  


Ser Gly Ser Leu Leu Gly Gly Lys Ala Ala Leu Thr Ile Ser Gly Ala 
65                  70                  75                  80  


Gln Pro Glu Asp Glu Ala Glu Tyr Tyr Cys Val Leu Trp Tyr Ser Asp 
                85                  90                  95      


His Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Gly Gly 
            100                 105                 110         


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro 
    130                 135                 140                 


Ser Glu Thr Leu Ser Ile Thr Cys Thr Val Ser Gly Phe Leu Leu Thr 
145                 150                 155                 160 


Asp Tyr Gly Val Asn Trp Val Arg Gln Pro Pro Gly Lys Gly Leu Glu 
                165                 170                 175     


Trp Leu Gly Val Ile Trp Gly Asp Gly Ile Thr Asp Tyr Asn Pro Ser 
            180                 185                 190         


Leu Lys Ser Arg Leu Thr Val Ser Lys Asp Thr Ser Lys Asn Gln Val 
        195                 200                 205             


Ser Leu Lys Met Ser Ser Leu Thr Asp Ala Asp Thr Ala Arg Tyr Tyr 
    210                 215                 220                 


Cys Val Thr Gly Leu Phe Asp Tyr Trp Gly Gln Gly Thr Thr Leu Thr 
225                 230                 235                 240 


Val Ser Ser 
            


<210>  310
<211>  243
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - Humanized scFv fragments

<400>  310

Gln Ala Val Val Thr Gln Glu Pro Ser Leu Thr Val Ser Pro Gly Gly 
1               5                   10                  15      


Thr Val Thr Leu Thr Cys Gly Ser Ser Thr Gly Ala Val Thr Thr Ser 
            20                  25                  30          


Asn Tyr Ala Ser Trp Val Gln Gln Lys Pro Asp His Leu Phe Arg Gly 
        35                  40                  45              


Leu Ile Gly Gly Thr Asn Asn Arg Ala Pro Gly Val Pro Ala Arg Phe 
    50                  55                  60                  


Ser Gly Ser Leu Ile Gly Asp Lys Ala Ala Leu Thr Ile Ser Gly Ala 
65                  70                  75                  80  


Gln Pro Glu Asp Glu Ala Glu Tyr Tyr Cys Val Leu Trp Tyr Ser Asp 
                85                  90                  95      


His Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Gly Gly 
            100                 105                 110         


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro 
    130                 135                 140                 


Ser Glu Thr Leu Ser Ile Thr Cys Thr Val Ser Gly Phe Leu Leu Thr 
145                 150                 155                 160 


Asp Tyr Gly Val Asn Trp Val Arg Gln Pro Pro Gly Lys Gly Leu Glu 
                165                 170                 175     


Trp Leu Gly Val Ile Trp Gly Asp Gly Ile Thr Asp Tyr Asn Pro Ser 
            180                 185                 190         


Leu Lys Ser Arg Leu Thr Val Ser Lys Asp Thr Ser Lys Asn Gln Val 
        195                 200                 205             


Ser Leu Lys Met Ser Ser Leu Thr Ala Ala Asp Thr Ala Arg Tyr Tyr 
    210                 215                 220                 


Cys Val Thr Gly Leu Phe Asp Tyr Trp Gly Gln Gly Thr Thr Leu Thr 
225                 230                 235                 240 


Val Ser Ser 
            


<210>  311
<211>  243
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - Humanized scFv fragments

<400>  311

Gln Ala Val Val Thr Gln Glu Pro Ser Leu Thr Val Ser Pro Gly Gly 
1               5                   10                  15      


Thr Val Thr Leu Thr Cys Arg Ser Ser Thr Gly Ala Val Thr Thr Ser 
            20                  25                  30          


Asn Tyr Ala Ser Trp Val Gln Gln Lys Pro Asp His Leu Phe Arg Gly 
        35                  40                  45              


Leu Ile Gly Gly Thr Asn Asn Arg Ala Pro Gly Val Pro Ala Arg Phe 
    50                  55                  60                  


Ser Gly Ser Leu Ile Gly Asp Lys Ala Ala Leu Thr Ile Ser Gly Ala 
65                  70                  75                  80  


Gln Pro Glu Asp Glu Ala Glu Tyr Tyr Cys Val Leu Trp Tyr Ser Asp 
                85                  90                  95      


His Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Gly Gly 
            100                 105                 110         


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro 
    130                 135                 140                 


Ser Glu Thr Leu Ser Ile Thr Cys Thr Val Ser Gly Phe Leu Leu Thr 
145                 150                 155                 160 


Asp Tyr Gly Val Asn Trp Val Arg Gln Pro Pro Gly Lys Gly Leu Glu 
                165                 170                 175     


Trp Leu Gly Val Ile Trp Gly Asp Gly Ile Thr Asp Tyr Asn Pro Ser 
            180                 185                 190         


Leu Lys Ser Arg Leu Thr Val Ser Lys Asp Thr Ser Lys Asn Gln Val 
        195                 200                 205             


Ser Leu Lys Met Ser Ser Leu Thr Ala Ala Asp Thr Ala Arg Tyr Tyr 
    210                 215                 220                 


Cys Val Thr Gly Leu Phe Asp Tyr Trp Gly Gln Gly Thr Thr Leu Thr 
225                 230                 235                 240 


Val Ser Ser 
            


<210>  312
<211>  243
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - Humanized scFv fragments

<400>  312

Gln Ala Val Val Thr Gln Glu Pro Ser Leu Thr Val Ser Pro Gly Gly 
1               5                   10                  15      


Thr Val Thr Leu Thr Cys Arg Ser Ser Thr Gly Ala Val Thr Thr Ser 
            20                  25                  30          


Asn Tyr Ala Ser Trp Val Gln Gln Lys Pro Asp His Leu Phe Arg Gly 
        35                  40                  45              


Leu Ile Gly Gly Thr Asn Asn Arg Ala Pro Gly Val Pro Ala Arg Phe 
    50                  55                  60                  


Ser Gly Ser Leu Leu Gly Gly Lys Ala Ala Leu Thr Ile Ser Gly Ala 
65                  70                  75                  80  


Gln Pro Glu Asp Glu Ala Glu Tyr Tyr Cys Val Leu Trp Tyr Ser Asp 
                85                  90                  95      


His Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Gly Gly 
            100                 105                 110         


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro 
    130                 135                 140                 


Ser Glu Thr Leu Ser Ile Thr Cys Thr Val Ser Gly Phe Leu Leu Thr 
145                 150                 155                 160 


Asp Tyr Gly Val Asn Trp Val Arg Gln Pro Pro Gly Lys Gly Leu Glu 
                165                 170                 175     


Trp Leu Gly Val Ile Trp Gly Asp Gly Ile Thr Asp Tyr Asn Pro Ser 
            180                 185                 190         


Leu Lys Ser Arg Leu Thr Val Ser Lys Asp Thr Ser Lys Asn Gln Val 
        195                 200                 205             


Ser Leu Lys Met Ser Ser Leu Thr Ala Ala Asp Thr Ala Arg Tyr Tyr 
    210                 215                 220                 


Cys Val Thr Gly Leu Phe Asp Tyr Trp Gly Gln Gly Thr Thr Leu Thr 
225                 230                 235                 240 


Val Ser Ser 
            


<210>  313
<211>  243
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - Humanized scFv fragments

<400>  313

Gln Ala Val Val Thr Gln Glu Pro Ser Leu Thr Val Ser Pro Gly Gly 
1               5                   10                  15      


Thr Val Thr Leu Thr Cys Arg Ser Ser Thr Gly Ala Val Thr Thr Ser 
            20                  25                  30          


Asn Tyr Ala Ser Trp Val Gln Gln Lys Pro Asp His Leu Phe Arg Gly 
        35                  40                  45              


Leu Ile Gly Gly Thr Asn Asn Arg Ala Pro Gly Val Pro Ala Arg Phe 
    50                  55                  60                  


Ser Gly Ser Leu Leu Gly Gly Lys Ala Ala Leu Thr Ile Ser Gly Ala 
65                  70                  75                  80  


Gln Pro Glu Asp Glu Ala Glu Tyr Tyr Cys Val Leu Trp Tyr Ser Asp 
                85                  90                  95      


His Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Gly Gly 
            100                 105                 110         


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Gln Val Gln Leu Gln Gln Ser Gly Pro Gly Leu Val Lys Pro 
    130                 135                 140                 


Ser Glu Thr Leu Ser Ile Thr Cys Thr Val Ser Gly Phe Leu Leu Thr 
145                 150                 155                 160 


Asp Tyr Gly Val Asn Trp Val Arg Gln Pro Pro Gly Lys Gly Leu Glu 
                165                 170                 175     


Trp Leu Gly Val Ile Trp Gly Asp Gly Ile Thr Asp Tyr Asn Pro Ser 
            180                 185                 190         


Leu Lys Ser Arg Leu Thr Val Ser Lys Asp Thr Ser Lys Asn Gln Val 
        195                 200                 205             


Ser Leu Lys Met Ser Ser Leu Thr Ala Ala Asp Thr Ala Arg Tyr Tyr 
    210                 215                 220                 


Cys Val Thr Gly Leu Phe Asp Tyr Trp Gly Gln Gly Thr Thr Leu Thr 
225                 230                 235                 240 


Val Ser Ser 
            


<210>  314
<211>  243
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - Humanized scFv fragments

<400>  314

Gln Ala Val Val Thr Gln Glu Pro Ser Leu Thr Val Ser Pro Gly Gly 
1               5                   10                  15      


Thr Val Thr Leu Thr Cys Gly Ser Ser Thr Gly Ala Val Thr Thr Ser 
            20                  25                  30          


Asn Tyr Ala Ser Trp Val Gln Glu Lys Pro Asp His Leu Phe Arg Gly 
        35                  40                  45              


Leu Ile Gly Gly Thr Asn Asn Arg Ala Pro Gly Val Pro Ala Arg Phe 
    50                  55                  60                  


Ser Gly Ser Leu Leu Gly Gly Lys Ala Ala Leu Thr Ile Ser Gly Ala 
65                  70                  75                  80  


Gln Pro Glu Asp Glu Ala Ile Tyr Phe Cys Val Leu Trp Tyr Ser Asp 
                85                  90                  95      


His Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Gly Gly 
            100                 105                 110         


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro 
    130                 135                 140                 


Ser Glu Thr Leu Ser Ile Thr Cys Thr Val Ser Gly Phe Leu Leu Thr 
145                 150                 155                 160 


Asp Tyr Gly Val Asn Trp Val Arg Gln Pro Pro Gly Lys Gly Leu Glu 
                165                 170                 175     


Trp Leu Gly Val Ile Trp Gly Asp Gly Ile Thr Asp Tyr Asn Pro Ser 
            180                 185                 190         


Leu Lys Ser Arg Leu Thr Val Ser Lys Asp Thr Ser Lys Asn Gln Val 
        195                 200                 205             


Ser Leu Lys Met Ser Ser Leu Thr Ala Ala Asp Thr Ala Arg Tyr Tyr 
    210                 215                 220                 


Cys Val Thr Gly Leu Phe Asp Tyr Trp Gly Gln Gly Thr Thr Leu Thr 
225                 230                 235                 240 


Val Ser Ser 
            


<210>  315
<211>  243
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - Humanized scFv fragments

<400>  315

Gln Ala Val Val Thr Gln Glu Pro Ser Leu Thr Val Ser Pro Gly Gly 
1               5                   10                  15      


Thr Val Thr Leu Thr Cys Gly Ser Ser Thr Gly Ala Val Thr Thr Ser 
            20                  25                  30          


Asn Tyr Ala Ser Trp Val Gln Glu Lys Pro Asp His Leu Phe Arg Gly 
        35                  40                  45              


Leu Ile Gly Gly Thr Asn Asn Arg Ala Pro Gly Val Pro Ala Arg Phe 
    50                  55                  60                  


Ser Gly Ser Leu Leu Gly Gly Lys Ala Ala Leu Thr Ile Ser Gly Ala 
65                  70                  75                  80  


Gln Pro Glu Asp Glu Ala Ile Tyr Phe Cys Val Leu Trp Tyr Ser Asp 
                85                  90                  95      


His Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Gly Gly 
            100                 105                 110         


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Gln Val Gln Leu Gln Gln Ser Gly Pro Gly Leu Val Lys Pro 
    130                 135                 140                 


Ser Glu Thr Leu Ser Ile Thr Cys Thr Val Ser Gly Phe Leu Leu Thr 
145                 150                 155                 160 


Asp Tyr Gly Val Asn Trp Val Arg Gln Pro Pro Gly Lys Gly Leu Glu 
                165                 170                 175     


Trp Leu Gly Val Ile Trp Gly Asp Gly Ile Thr Asp Tyr Asn Pro Ser 
            180                 185                 190         


Leu Lys Ser Arg Leu Thr Val Ser Lys Asp Thr Ser Lys Asn Gln Val 
        195                 200                 205             


Ser Leu Lys Met Ser Ser Leu Thr Ala Ala Asp Thr Ala Arg Tyr Tyr 
    210                 215                 220                 


Cys Val Thr Gly Leu Phe Asp Tyr Trp Gly Gln Gly Thr Thr Leu Thr 
225                 230                 235                 240 


Val Ser Ser 
            


<210>  316
<211>  243
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - Humanized scFv fragments

<400>  316

Gln Ala Val Val Thr Gln Glu Pro Ser Leu Thr Val Ser Pro Gly Gly 
1               5                   10                  15      


Thr Val Thr Leu Thr Cys Gly Ser Ser Thr Gly Ala Val Thr Thr Ser 
            20                  25                  30          


Asn Tyr Ala Ser Trp Val Gln Glu Lys Pro Asp His Leu Phe Arg Gly 
        35                  40                  45              


Leu Ile Gly Gly Thr Asn Asn Arg Ala Pro Gly Val Pro Ala Arg Phe 
    50                  55                  60                  


Ser Gly Ser Leu Leu Gly Gly Lys Ala Ala Leu Thr Ile Ser Gly Ala 
65                  70                  75                  80  


Gln Pro Glu Asp Glu Ala Ile Tyr Phe Cys Val Leu Trp Tyr Ser Asp 
                85                  90                  95      


His Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Gly Gly 
            100                 105                 110         


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro 
    130                 135                 140                 


Ser Glu Thr Leu Ser Ile Thr Cys Thr Val Ser Gly Phe Leu Leu Thr 
145                 150                 155                 160 


Asp Tyr Gly Val Asn Trp Val Arg Gln Pro Pro Gly Lys Gly Leu Glu 
                165                 170                 175     


Trp Leu Gly Val Ile Trp Gly Asp Gly Ile Thr Asp Tyr Asn Pro Ser 
            180                 185                 190         


Leu Lys Ser Arg Leu Thr Val Ser Lys Asp Thr Ser Lys Asn Gln Val 
        195                 200                 205             


Ser Leu Lys Met Ser Ser Leu Thr Asp Ala Asp Thr Ala Arg Tyr Tyr 
    210                 215                 220                 


Cys Val Thr Gly Leu Phe Asp Tyr Trp Gly Gln Gly Thr Thr Leu Thr 
225                 230                 235                 240 


Val Ser Ser 
            


<210>  317
<211>  243
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - Humanized scFv fragments

<400>  317

Gln Ala Val Val Thr Gln Glu Pro Ser Leu Thr Val Ser Pro Gly Gly 
1               5                   10                  15      


Thr Val Thr Leu Thr Cys Gly Ser Ser Thr Gly Ala Val Thr Thr Ser 
            20                  25                  30          


Asn Tyr Ala Ser Trp Val Gln Glu Lys Pro Asp His Leu Phe Arg Gly 
        35                  40                  45              


Leu Ile Gly Gly Thr Asn Asn Arg Ala Pro Gly Val Pro Ala Arg Phe 
    50                  55                  60                  


Ser Gly Ser Leu Leu Gly Gly Lys Ala Ala Leu Thr Ile Ser Gly Ala 
65                  70                  75                  80  


Gln Pro Glu Asp Glu Ala Ile Tyr Phe Cys Val Leu Trp Tyr Ser Asp 
                85                  90                  95      


His Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Gly Gly 
            100                 105                 110         


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Gln Val Gln Leu Gln Gln Ser Gly Pro Gly Leu Val Lys Pro 
    130                 135                 140                 


Ser Glu Thr Leu Ser Ile Thr Cys Thr Val Ser Gly Phe Leu Leu Thr 
145                 150                 155                 160 


Asp Tyr Gly Val Asn Trp Val Arg Gln Pro Pro Gly Lys Gly Leu Glu 
                165                 170                 175     


Trp Leu Gly Val Ile Trp Gly Asp Gly Ile Thr Asp Tyr Asn Pro Ser 
            180                 185                 190         


Leu Lys Ser Arg Leu Thr Val Ser Lys Asp Thr Ser Lys Asn Gln Val 
        195                 200                 205             


Ser Leu Lys Met Ser Ser Leu Thr Asp Ala Asp Thr Ala Arg Tyr Tyr 
    210                 215                 220                 


Cys Val Thr Gly Leu Phe Asp Tyr Trp Gly Gln Gly Thr Thr Leu Thr 
225                 230                 235                 240 


Val Ser Ser 
            


<210>  318
<211>  243
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - Humanized scFv fragments

<400>  318

Gln Ala Val Val Thr Gln Glu Pro Ser Leu Thr Ser Ser Pro Gly Gly 
1               5                   10                  15      


Thr Val Thr Leu Thr Cys Gly Ser Ser Thr Gly Ala Val Thr Thr Ser 
            20                  25                  30          


Asn Tyr Ala Ser Trp Val Gln Glu Lys Pro Asp His Leu Phe Arg Gly 
        35                  40                  45              


Leu Ile Gly Gly Thr Asn Asn Arg Ala Pro Gly Val Pro Ala Arg Phe 
    50                  55                  60                  


Ser Gly Ser Leu Leu Gly Gly Lys Ala Ala Leu Thr Ile Ser Gly Ala 
65                  70                  75                  80  


Gln Pro Glu Asp Glu Ala Ile Tyr Phe Cys Val Leu Trp Tyr Ser Asp 
                85                  90                  95      


His Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Gly Gly 
            100                 105                 110         


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro 
    130                 135                 140                 


Ser Glu Thr Leu Ser Ile Thr Cys Thr Val Ser Gly Phe Leu Leu Thr 
145                 150                 155                 160 


Asp Tyr Gly Val Asn Trp Val Arg Gln Pro Pro Gly Lys Gly Leu Glu 
                165                 170                 175     


Trp Leu Gly Val Ile Trp Gly Asp Gly Ile Thr Asp Tyr Asn Pro Ser 
            180                 185                 190         


Leu Lys Ser Arg Leu Thr Val Ser Lys Asp Thr Ser Lys Asn Gln Val 
        195                 200                 205             


Ser Leu Lys Met Ser Ser Leu Thr Ala Ala Asp Thr Ala Arg Tyr Tyr 
    210                 215                 220                 


Cys Val Thr Gly Leu Phe Asp Tyr Trp Gly Gln Gly Thr Thr Leu Thr 
225                 230                 235                 240 


Val Ser Ser 
            


<210>  319
<211>  243
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - Humanized scFv fragments

<400>  319

Gln Ala Val Val Thr Gln Glu Pro Ser Leu Thr Ser Ser Pro Gly Gly 
1               5                   10                  15      


Thr Val Thr Leu Thr Cys Gly Ser Ser Thr Gly Ala Val Thr Thr Ser 
            20                  25                  30          


Asn Tyr Ala Ser Trp Val Gln Glu Lys Pro Asp His Leu Phe Arg Gly 
        35                  40                  45              


Leu Ile Gly Gly Thr Asn Asn Arg Ala Pro Gly Val Pro Ala Arg Phe 
    50                  55                  60                  


Ser Gly Ser Leu Leu Gly Gly Lys Ala Ala Leu Thr Ile Ser Gly Ala 
65                  70                  75                  80  


Gln Pro Glu Asp Glu Ala Ile Tyr Phe Cys Val Leu Trp Tyr Ser Asp 
                85                  90                  95      


His Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Gly Gly 
            100                 105                 110         


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro 
    130                 135                 140                 


Ser Glu Thr Leu Ser Ile Thr Cys Thr Val Ser Gly Phe Leu Leu Thr 
145                 150                 155                 160 


Asp Tyr Gly Val Asn Trp Val Arg Gln Pro Pro Gly Lys Gly Leu Glu 
                165                 170                 175     


Trp Leu Gly Val Ile Trp Gly Asp Gly Ile Thr Asp Tyr Asn Pro Ser 
            180                 185                 190         


Leu Lys Ser Arg Leu Thr Val Ser Lys Asp Thr Ser Lys Asn Gln Val 
        195                 200                 205             


Ser Leu Lys Met Ser Ser Leu Thr Asp Ala Asp Thr Ala Arg Tyr Tyr 
    210                 215                 220                 


Cys Val Thr Gly Leu Phe Asp Tyr Trp Gly Gln Gly Thr Thr Leu Thr 
225                 230                 235                 240 


Val Ser Ser 
            


<210>  320
<211>  243
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - Humanized scFv fragments

<400>  320

Gln Ala Val Val Thr Gln Glu Pro Ser Leu Thr Val Ser Pro Gly Gly 
1               5                   10                  15      


Thr Val Thr Leu Thr Cys Gly Ser Ser Thr Gly Ala Val Thr Thr Ser 
            20                  25                  30          


Asn Tyr Ala Ser Trp Val Gln Glu Lys Pro Asp His Leu Phe Arg Gly 
        35                  40                  45              


Leu Ile Gly Gly Thr Asn Asn Arg Ala Pro Gly Val Pro Ala Arg Phe 
    50                  55                  60                  


Ser Gly Ser Leu Leu Gly Gly Lys Ala Ala Leu Thr Ile Ser Gly Ala 
65                  70                  75                  80  


Gln Pro Glu Asp Glu Ala Ile Tyr Phe Cys Val Leu Trp Tyr Ser Asp 
                85                  90                  95      


His Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Asp Gly Gly Gly 
            100                 105                 110         


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro 
    130                 135                 140                 


Ser Glu Thr Leu Ser Ile Thr Cys Thr Val Ser Gly Phe Leu Leu Thr 
145                 150                 155                 160 


Asp Tyr Gly Val Asn Trp Val Arg Gln Pro Pro Gly Lys Gly Leu Glu 
                165                 170                 175     


Trp Leu Gly Val Ile Trp Gly Asp Gly Ile Thr Asp Tyr Asn Pro Ser 
            180                 185                 190         


Leu Lys Ser Arg Leu Thr Val Ser Lys Asp Thr Ser Lys Asn Gln Val 
        195                 200                 205             


Ser Leu Lys Met Ser Ser Leu Thr Ala Ala Asp Thr Ala Arg Tyr Tyr 
    210                 215                 220                 


Cys Val Thr Gly Leu Phe Asp Tyr Trp Gly Gln Gly Thr Thr Leu Thr 
225                 230                 235                 240 


Val Ser Ser 
            


<210>  321
<211>  243
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - Humanized scFv fragments

<400>  321

Gln Ala Val Val Thr Gln Glu Pro Ser Leu Thr Val Ser Pro Gly Gly 
1               5                   10                  15      


Thr Val Thr Leu Thr Cys Gly Ser Ser Thr Gly Ala Val Thr Thr Ser 
            20                  25                  30          


Asn Tyr Ala Ser Trp Val Gln Glu Lys Pro Asp His Leu Phe Arg Gly 
        35                  40                  45              


Leu Ile Gly Gly Thr Asn Asn Arg Ala Pro Gly Val Pro Ala Arg Phe 
    50                  55                  60                  


Ser Gly Ser Leu Leu Gly Gly Lys Ala Ala Leu Thr Ile Ser Gly Ala 
65                  70                  75                  80  


Gln Pro Glu Asp Glu Ala Ile Tyr Phe Cys Val Leu Trp Tyr Ser Asp 
                85                  90                  95      


His Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Asp Gly Gly Gly 
            100                 105                 110         


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro 
    130                 135                 140                 


Ser Glu Thr Leu Ser Ile Thr Cys Thr Val Ser Gly Phe Leu Leu Thr 
145                 150                 155                 160 


Asp Tyr Gly Val Asn Trp Val Arg Gln Pro Pro Gly Lys Gly Leu Glu 
                165                 170                 175     


Trp Leu Gly Val Ile Trp Gly Asp Gly Ile Thr Asp Tyr Asn Pro Ser 
            180                 185                 190         


Leu Lys Ser Arg Leu Thr Val Ser Lys Asp Thr Ser Lys Asn Gln Val 
        195                 200                 205             


Ser Leu Lys Met Ser Ser Leu Thr Asp Ala Asp Thr Ala Arg Tyr Tyr 
    210                 215                 220                 


Cys Val Thr Gly Leu Phe Asp Tyr Trp Gly Gln Gly Thr Thr Leu Thr 
225                 230                 235                 240 


Val Ser Ser 
            


<210>  322
<211>  243
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - Humanized scFv fragments

<400>  322

Gln Ala Val Val Thr Gln Glu Pro Ser Leu Thr Val Ser Pro Gly Gly 
1               5                   10                  15      


Thr Val Thr Leu Thr Cys Gly Ser Ser Thr Gly Ala Val Thr Thr Ser 
            20                  25                  30          


Asn Tyr Ala Ser Trp Val Gln Glu Lys Pro Asp His Leu Phe Arg Gly 
        35                  40                  45              


Leu Ile Gly Gly Thr Asn Asn Arg Ala Pro Gly Val Pro Ala Arg Phe 
    50                  55                  60                  


Ser Gly Ser Leu Leu Gly Gly Lys Ala Ala Leu Thr Ile Ser Gly Ala 
65                  70                  75                  80  


Gln Pro Glu Asp Glu Ala Ile Tyr Phe Cys Val Leu Trp Tyr Ser Asp 
                85                  90                  95      


His Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Asp Gly Gly Gly 
            100                 105                 110         


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Gln Val Gln Leu Gln Gln Ser Gly Pro Gly Leu Val Lys Pro 
    130                 135                 140                 


Ser Glu Thr Leu Ser Ile Thr Cys Thr Val Ser Gly Phe Leu Leu Thr 
145                 150                 155                 160 


Asp Tyr Gly Val Asn Trp Val Arg Gln Pro Pro Gly Lys Gly Leu Glu 
                165                 170                 175     


Trp Leu Gly Val Ile Trp Gly Asp Gly Ile Thr Asp Tyr Asn Pro Ser 
            180                 185                 190         


Leu Lys Ser Arg Leu Thr Val Ser Lys Asp Thr Ser Lys Asn Gln Val 
        195                 200                 205             


Ser Leu Lys Met Ser Ser Leu Thr Asp Ala Asp Thr Ala Arg Tyr Tyr 
    210                 215                 220                 


Cys Val Thr Gly Leu Phe Asp Tyr Trp Gly Gln Gly Thr Thr Leu Thr 
225                 230                 235                 240 


Val Ser Ser 
            


<210>  323
<211>  243
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - Humanized scFv fragments

<400>  323

Gln Ala Val Val Thr Gln Glu Pro Ser Leu Thr Ser Ser Pro Gly Gly 
1               5                   10                  15      


Thr Val Thr Leu Thr Cys Gly Ser Ser Thr Gly Ala Val Thr Thr Ser 
            20                  25                  30          


Asn Tyr Ala Ser Trp Val Gln Glu Lys Pro Asp His Leu Phe Arg Gly 
        35                  40                  45              


Leu Ile Gly Gly Thr Asn Asn Arg Ala Pro Gly Val Pro Ala Arg Phe 
    50                  55                  60                  


Ser Gly Ser Leu Leu Gly Gly Lys Ala Ala Leu Thr Ile Ser Gly Ala 
65                  70                  75                  80  


Gln Pro Glu Asp Glu Ala Ile Tyr Phe Cys Val Leu Trp Tyr Ser Asp 
                85                  90                  95      


His Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Asp Gly Gly Gly 
            100                 105                 110         


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro 
    130                 135                 140                 


Ser Glu Thr Leu Ser Ile Thr Cys Thr Val Ser Gly Phe Leu Leu Thr 
145                 150                 155                 160 


Asp Tyr Gly Val Asn Trp Val Arg Gln Pro Pro Gly Lys Gly Leu Glu 
                165                 170                 175     


Trp Leu Gly Val Ile Trp Gly Asp Gly Ile Thr Asp Tyr Asn Pro Ser 
            180                 185                 190         


Leu Lys Ser Arg Leu Thr Val Ser Lys Asp Thr Ser Lys Asn Gln Val 
        195                 200                 205             


Ser Leu Lys Met Ser Ser Leu Thr Asp Ala Asp Thr Ala Arg Tyr Tyr 
    210                 215                 220                 


Cys Val Thr Gly Leu Phe Asp Tyr Trp Gly Gln Gly Thr Thr Leu Thr 
225                 230                 235                 240 


Val Ser Ser 
            


<210>  324
<211>  243
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - Humanized scFv fragments

<400>  324

Gln Ala Val Val Thr Gln Glu Pro Ser Leu Thr Ser Ser Pro Gly Gly 
1               5                   10                  15      


Thr Val Thr Leu Thr Cys Gly Ser Ser Thr Gly Ala Val Thr Thr Ser 
            20                  25                  30          


Asn Tyr Ala Ser Trp Val Gln Glu Lys Pro Asp His Leu Phe Arg Gly 
        35                  40                  45              


Leu Ile Gly Gly Thr Asn Asn Arg Ala Pro Gly Val Pro Ala Arg Phe 
    50                  55                  60                  


Ser Gly Ser Leu Leu Gly Gly Lys Ala Ala Leu Thr Ile Ser Gly Ala 
65                  70                  75                  80  


Gln Pro Glu Asp Glu Ala Ile Tyr Phe Cys Val Leu Trp Tyr Ser Asp 
                85                  90                  95      


His Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Asp Gly Gly Gly 
            100                 105                 110         


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Gln Val Gln Leu Gln Gln Ser Gly Pro Gly Leu Val Lys Pro 
    130                 135                 140                 


Ser Glu Thr Leu Ser Ile Thr Cys Thr Val Ser Gly Phe Leu Leu Thr 
145                 150                 155                 160 


Asp Tyr Gly Val Asn Trp Val Arg Gln Pro Pro Gly Lys Gly Leu Glu 
                165                 170                 175     


Trp Leu Gly Val Ile Trp Gly Asp Gly Ile Thr Asp Tyr Asn Pro Ser 
            180                 185                 190         


Leu Lys Ser Arg Leu Thr Val Ser Lys Asp Thr Ser Lys Asn Gln Val 
        195                 200                 205             


Ser Leu Lys Met Ser Ser Leu Thr Asp Ala Asp Thr Ala Arg Tyr Tyr 
    210                 215                 220                 


Cys Val Thr Gly Leu Phe Asp Tyr Trp Gly Gln Gly Thr Thr Leu Thr 
225                 230                 235                 240 


Val Ser Ser 
            


<210>  325
<211>  243
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - Humanized scFv fragments

<400>  325

Gln Ala Val Val Thr Gln Glu Pro Ser Leu Thr Ser Ser Pro Gly Gly 
1               5                   10                  15      


Thr Val Thr Leu Thr Cys Gly Ser Ser Thr Gly Ala Val Thr Thr Ser 
            20                  25                  30          


Asn Tyr Ala Ser Trp Val Gln Gln Lys Pro Asp His Leu Phe Arg Gly 
        35                  40                  45              


Leu Ile Gly Gly Thr Asn Asn Arg Ala Pro Gly Val Pro Ala Arg Phe 
    50                  55                  60                  


Ser Gly Ser Leu Leu Gly Gly Lys Ala Ala Leu Thr Ile Ser Gly Ala 
65                  70                  75                  80  


Gln Pro Glu Asp Glu Ala Ile Tyr Phe Cys Val Leu Trp Tyr Ser Asp 
                85                  90                  95      


His Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Asp Gly Gly Gly 
            100                 105                 110         


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Gln Val Gln Leu Gln Gln Ser Gly Pro Gly Leu Val Lys Pro 
    130                 135                 140                 


Ser Glu Thr Leu Ser Ile Thr Cys Thr Val Ser Gly Phe Leu Leu Thr 
145                 150                 155                 160 


Asp Tyr Gly Val Asn Trp Val Arg Gln Pro Pro Gly Lys Gly Leu Glu 
                165                 170                 175     


Trp Leu Gly Val Ile Trp Gly Asp Gly Ile Thr Asp Tyr Asn Pro Ser 
            180                 185                 190         


Leu Lys Ser Arg Leu Thr Val Ser Lys Asp Thr Ser Lys Asn Gln Val 
        195                 200                 205             


Ser Leu Lys Met Ser Ser Leu Thr Asp Ala Asp Thr Ala Arg Tyr Tyr 
    210                 215                 220                 


Cys Val Thr Gly Leu Phe Asp Tyr Trp Gly Gln Gly Thr Thr Leu Thr 
225                 230                 235                 240 


Val Ser Ser 
            


<210>  326
<211>  243
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - Humanized scFv fragments

<400>  326

Gln Ala Val Val Thr Gln Glu Pro Ser Leu Thr Ser Ser Pro Gly Gly 
1               5                   10                  15      


Thr Val Thr Leu Thr Cys Gly Ser Ser Thr Gly Ala Val Thr Thr Ser 
            20                  25                  30          


Asn Tyr Ala Ser Trp Val Gln Glu Lys Pro Asp His Leu Phe Arg Gly 
        35                  40                  45              


Leu Ile Gly Gly Thr Asn Asn Arg Ala Pro Gly Val Pro Ala Arg Phe 
    50                  55                  60                  


Ser Gly Ser Leu Leu Gly Gly Lys Ala Ala Leu Thr Ile Ser Gly Ala 
65                  70                  75                  80  


Gln Pro Glu Asp Glu Ala Glu Tyr Phe Cys Val Leu Trp Tyr Ser Asp 
                85                  90                  95      


His Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Asp Gly Gly Gly 
            100                 105                 110         


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Gln Val Gln Leu Gln Gln Ser Gly Pro Gly Leu Val Lys Pro 
    130                 135                 140                 


Ser Glu Thr Leu Ser Ile Thr Cys Thr Val Ser Gly Phe Leu Leu Thr 
145                 150                 155                 160 


Asp Tyr Gly Val Asn Trp Val Arg Gln Pro Pro Gly Lys Gly Leu Glu 
                165                 170                 175     


Trp Leu Gly Val Ile Trp Gly Asp Gly Ile Thr Asp Tyr Asn Pro Ser 
            180                 185                 190         


Leu Lys Ser Arg Leu Thr Val Ser Lys Asp Thr Ser Lys Asn Gln Val 
        195                 200                 205             


Ser Leu Lys Met Ser Ser Leu Thr Asp Ala Asp Thr Ala Arg Tyr Tyr 
    210                 215                 220                 


Cys Val Thr Gly Leu Phe Asp Tyr Trp Gly Gln Gly Thr Thr Leu Thr 
225                 230                 235                 240 


Val Ser Ser 
            


<210>  327
<211>  243
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - Humanized scFv fragments

<400>  327

Gln Ala Val Val Thr Gln Glu Pro Ser Leu Thr Ser Ser Pro Gly Gly 
1               5                   10                  15      


Thr Val Thr Leu Thr Cys Gly Ser Ser Thr Gly Ala Val Thr Thr Ser 
            20                  25                  30          


Asn Tyr Ala Ser Trp Val Gln Glu Lys Pro Asp His Leu Phe Arg Gly 
        35                  40                  45              


Leu Ile Gly Gly Thr Asn Asn Arg Ala Pro Gly Val Pro Ala Arg Phe 
    50                  55                  60                  


Ser Gly Ser Leu Leu Gly Gly Lys Ala Ala Leu Thr Ile Ser Gly Ala 
65                  70                  75                  80  


Gln Pro Glu Asp Glu Ala Ile Tyr Tyr Cys Val Leu Trp Tyr Ser Asp 
                85                  90                  95      


His Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Asp Gly Gly Gly 
            100                 105                 110         


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Gln Val Gln Leu Gln Gln Ser Gly Pro Gly Leu Val Lys Pro 
    130                 135                 140                 


Ser Glu Thr Leu Ser Ile Thr Cys Thr Val Ser Gly Phe Leu Leu Thr 
145                 150                 155                 160 


Asp Tyr Gly Val Asn Trp Val Arg Gln Pro Pro Gly Lys Gly Leu Glu 
                165                 170                 175     


Trp Leu Gly Val Ile Trp Gly Asp Gly Ile Thr Asp Tyr Asn Pro Ser 
            180                 185                 190         


Leu Lys Ser Arg Leu Thr Val Ser Lys Asp Thr Ser Lys Asn Gln Val 
        195                 200                 205             


Ser Leu Lys Met Ser Ser Leu Thr Asp Ala Asp Thr Ala Arg Tyr Tyr 
    210                 215                 220                 


Cys Val Thr Gly Leu Phe Asp Tyr Trp Gly Gln Gly Thr Thr Leu Thr 
225                 230                 235                 240 


Val Ser Ser 
            


<210>  328
<211>  243
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - Humanized scFv fragments

<400>  328

Gln Ala Val Val Thr Gln Glu Pro Ser Leu Thr Ser Ser Pro Gly Gly 
1               5                   10                  15      


Thr Val Thr Leu Thr Cys Gly Ser Ser Thr Gly Ala Val Thr Thr Ser 
            20                  25                  30          


Asn Tyr Ala Ser Trp Val Gln Gln Lys Pro Asp His Leu Phe Arg Gly 
        35                  40                  45              


Leu Ile Gly Gly Thr Asn Asn Arg Ala Pro Gly Val Pro Ala Arg Phe 
    50                  55                  60                  


Ser Gly Ser Leu Leu Gly Gly Lys Ala Ala Leu Thr Ile Ser Gly Ala 
65                  70                  75                  80  


Gln Pro Glu Asp Glu Ala Glu Tyr Phe Cys Val Leu Trp Tyr Ser Asp 
                85                  90                  95      


His Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Asp Gly Gly Gly 
            100                 105                 110         


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Gln Val Gln Leu Gln Gln Ser Gly Pro Gly Leu Val Lys Pro 
    130                 135                 140                 


Ser Glu Thr Leu Ser Ile Thr Cys Thr Val Ser Gly Phe Leu Leu Thr 
145                 150                 155                 160 


Asp Tyr Gly Val Asn Trp Val Arg Gln Pro Pro Gly Lys Gly Leu Glu 
                165                 170                 175     


Trp Leu Gly Val Ile Trp Gly Asp Gly Ile Thr Asp Tyr Asn Pro Ser 
            180                 185                 190         


Leu Lys Ser Arg Leu Thr Val Ser Lys Asp Thr Ser Lys Asn Gln Val 
        195                 200                 205             


Ser Leu Lys Met Ser Ser Leu Thr Asp Ala Asp Thr Ala Arg Tyr Tyr 
    210                 215                 220                 


Cys Val Thr Gly Leu Phe Asp Tyr Trp Gly Gln Gly Thr Thr Leu Thr 
225                 230                 235                 240 


Val Ser Ser 
            


<210>  329
<211>  243
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - Humanized scFv fragments

<400>  329

Gln Ala Val Val Thr Gln Glu Pro Ser Leu Thr Ser Ser Pro Gly Gly 
1               5                   10                  15      


Thr Val Thr Leu Thr Cys Gly Ser Ser Thr Gly Ala Val Thr Thr Ser 
            20                  25                  30          


Asn Tyr Ala Ser Trp Val Gln Gln Lys Pro Asp His Leu Phe Arg Gly 
        35                  40                  45              


Leu Ile Gly Gly Thr Asn Asn Arg Ala Pro Gly Val Pro Ala Arg Phe 
    50                  55                  60                  


Ser Gly Ser Leu Leu Gly Gly Lys Ala Ala Leu Thr Ile Ser Gly Ala 
65                  70                  75                  80  


Gln Pro Glu Asp Glu Ala Ile Tyr Tyr Cys Val Leu Trp Tyr Ser Asp 
                85                  90                  95      


His Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Asp Gly Gly Gly 
            100                 105                 110         


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Gln Val Gln Leu Gln Gln Ser Gly Pro Gly Leu Val Lys Pro 
    130                 135                 140                 


Ser Glu Thr Leu Ser Ile Thr Cys Thr Val Ser Gly Phe Leu Leu Thr 
145                 150                 155                 160 


Asp Tyr Gly Val Asn Trp Val Arg Gln Pro Pro Gly Lys Gly Leu Glu 
                165                 170                 175     


Trp Leu Gly Val Ile Trp Gly Asp Gly Ile Thr Asp Tyr Asn Pro Ser 
            180                 185                 190         


Leu Lys Ser Arg Leu Thr Val Ser Lys Asp Thr Ser Lys Asn Gln Val 
        195                 200                 205             


Ser Leu Lys Met Ser Ser Leu Thr Asp Ala Asp Thr Ala Arg Tyr Tyr 
    210                 215                 220                 


Cys Val Thr Gly Leu Phe Asp Tyr Trp Gly Gln Gly Thr Thr Leu Thr 
225                 230                 235                 240 


Val Ser Ser 
            


<210>  330
<211>  243
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - Humanized scFv fragments

<400>  330

Gln Ala Val Val Thr Gln Glu Pro Ser Leu Thr Ser Ser Pro Gly Gly 
1               5                   10                  15      


Thr Val Thr Leu Thr Cys Gly Ser Ser Thr Gly Ala Val Thr Thr Ser 
            20                  25                  30          


Asn Tyr Ala Ser Trp Val Gln Glu Lys Pro Asp His Leu Phe Arg Gly 
        35                  40                  45              


Leu Ile Gly Gly Thr Asn Asn Arg Ala Pro Gly Val Pro Ala Arg Phe 
    50                  55                  60                  


Ser Gly Ser Leu Leu Gly Gly Lys Ala Ala Leu Thr Ile Ser Gly Ala 
65                  70                  75                  80  


Gln Pro Glu Asp Glu Ala Glu Tyr Tyr Cys Val Leu Trp Tyr Ser Asp 
                85                  90                  95      


His Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Asp Gly Gly Gly 
            100                 105                 110         


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Gln Val Gln Leu Gln Gln Ser Gly Pro Gly Leu Val Lys Pro 
    130                 135                 140                 


Ser Glu Thr Leu Ser Ile Thr Cys Thr Val Ser Gly Phe Leu Leu Thr 
145                 150                 155                 160 


Asp Tyr Gly Val Asn Trp Val Arg Gln Pro Pro Gly Lys Gly Leu Glu 
                165                 170                 175     


Trp Leu Gly Val Ile Trp Gly Asp Gly Ile Thr Asp Tyr Asn Pro Ser 
            180                 185                 190         


Leu Lys Ser Arg Leu Thr Val Ser Lys Asp Thr Ser Lys Asn Gln Val 
        195                 200                 205             


Ser Leu Lys Met Ser Ser Leu Thr Asp Ala Asp Thr Ala Arg Tyr Tyr 
    210                 215                 220                 


Cys Val Thr Gly Leu Phe Asp Tyr Trp Gly Gln Gly Thr Thr Leu Thr 
225                 230                 235                 240 


Val Ser Ser 
            


<210>  331
<211>  243
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - Humanized scFv fragments

<400>  331

Gln Ala Val Val Thr Gln Glu Pro Ser Leu Thr Ser Ser Pro Gly Gly 
1               5                   10                  15      


Thr Val Thr Leu Thr Cys Gly Ser Ser Thr Gly Ala Val Thr Thr Ser 
            20                  25                  30          


Asn Tyr Ala Ser Trp Val Gln Gln Lys Pro Asp His Leu Phe Arg Gly 
        35                  40                  45              


Leu Ile Gly Gly Thr Asn Asn Arg Ala Pro Gly Val Pro Ala Arg Phe 
    50                  55                  60                  


Ser Gly Ser Leu Leu Gly Gly Lys Ala Ala Leu Thr Ile Ser Gly Ala 
65                  70                  75                  80  


Gln Pro Glu Asp Glu Ala Glu Tyr Tyr Cys Val Leu Trp Tyr Ser Asp 
                85                  90                  95      


His Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Asp Gly Gly Gly 
            100                 105                 110         


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Gln Val Gln Leu Gln Gln Ser Gly Pro Gly Leu Val Lys Pro 
    130                 135                 140                 


Ser Glu Thr Leu Ser Ile Thr Cys Thr Val Ser Gly Phe Leu Leu Thr 
145                 150                 155                 160 


Asp Tyr Gly Val Asn Trp Val Arg Gln Pro Pro Gly Lys Gly Leu Glu 
                165                 170                 175     


Trp Leu Gly Val Ile Trp Gly Asp Gly Ile Thr Asp Tyr Asn Pro Ser 
            180                 185                 190         


Leu Lys Ser Arg Leu Thr Val Ser Lys Asp Thr Ser Lys Asn Gln Val 
        195                 200                 205             


Ser Leu Lys Met Ser Ser Leu Thr Asp Ala Asp Thr Ala Arg Tyr Tyr 
    210                 215                 220                 


Cys Val Thr Gly Leu Phe Asp Tyr Trp Gly Gln Gly Thr Thr Leu Thr 
225                 230                 235                 240 


Val Ser Ser 
            


<210>  332
<211>  243
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - Humanized scFv fragments

<400>  332

Gln Ala Val Val Thr Gln Glu Pro Ser Leu Thr Val Ser Pro Gly Gly 
1               5                   10                  15      


Thr Val Thr Leu Thr Cys Gly Ser Ser Thr Gly Ala Val Thr Thr Ser 
            20                  25                  30          


Asn Tyr Ala Ser Trp Val Gln Glu Lys Pro Asp His Leu Phe Arg Gly 
        35                  40                  45              


Leu Ile Gly Gly Thr Asn Asn Arg Ala Pro Gly Val Pro Ala Arg Phe 
    50                  55                  60                  


Ser Gly Ser Leu Leu Gly Gly Lys Ala Ala Leu Thr Ile Ser Gly Ala 
65                  70                  75                  80  


Gln Pro Glu Asp Glu Ala Ile Tyr Phe Cys Val Leu Trp Tyr Ser Asp 
                85                  90                  95      


His Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Asp Gly Gly Gly 
            100                 105                 110         


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Asp Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Ala Pro 
    130                 135                 140                 


Ser Gln Ser Leu Ser Ile Thr Cys Thr Val Ser Gly Phe Leu Leu Thr 
145                 150                 155                 160 


Asp Tyr Gly Val Asn Trp Val Arg Gln Ser Pro Gly Lys Gly Leu Glu 
                165                 170                 175     


Trp Leu Gly Val Ile Trp Gly Asp Gly Ile Thr Asp Tyr Asn Ser Ala 
            180                 185                 190         


Leu Lys Ser Arg Leu Ser Val Thr Lys Asp Asn Ser Lys Ser Gln Val 
        195                 200                 205             


Phe Leu Lys Met Asn Ser Leu Gln Ser Gly Asp Ser Ala Arg Tyr Tyr 
    210                 215                 220                 


Cys Val Thr Gly Leu Phe Asp Tyr Trp Gly Gln Gly Thr Thr Leu Thr 
225                 230                 235                 240 


Val Ser Ser 
            


<210>  333
<211>  243
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - Humanized scFv fragments

<400>  333

Gln Ala Val Val Thr Gln Glu Pro Ser Leu Thr Ser Ser Pro Gly Gly 
1               5                   10                  15      


Thr Val Thr Leu Thr Cys Gly Ser Ser Thr Gly Ala Val Thr Thr Ser 
            20                  25                  30          


Asn Tyr Ala Ser Trp Val Gln Glu Lys Pro Asp His Leu Phe Arg Gly 
        35                  40                  45              


Leu Ile Gly Gly Thr Asn Asn Arg Ala Pro Gly Val Pro Ala Arg Phe 
    50                  55                  60                  


Ser Gly Ser Leu Leu Gly Gly Lys Ala Ala Leu Thr Ile Ser Gly Ala 
65                  70                  75                  80  


Gln Pro Glu Asp Glu Ala Ile Tyr Phe Cys Val Leu Trp Tyr Ser Asp 
                85                  90                  95      


His Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Asp Gly Gly Gly 
            100                 105                 110         


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Asp Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Ala Pro 
    130                 135                 140                 


Ser Gln Ser Leu Ser Ile Thr Cys Thr Val Ser Gly Phe Leu Leu Thr 
145                 150                 155                 160 


Asp Tyr Gly Val Asn Trp Val Arg Gln Ser Pro Gly Lys Gly Leu Glu 
                165                 170                 175     


Trp Leu Gly Val Ile Trp Gly Asp Gly Ile Thr Asp Tyr Asn Ser Ala 
            180                 185                 190         


Leu Lys Ser Arg Leu Ser Val Thr Lys Asp Asn Ser Lys Ser Gln Val 
        195                 200                 205             


Phe Leu Lys Met Asn Ser Leu Gln Ser Gly Asp Ser Ala Arg Tyr Tyr 
    210                 215                 220                 


Cys Val Thr Gly Leu Phe Asp Tyr Trp Gly Gln Gly Thr Thr Leu Thr 
225                 230                 235                 240 


Val Ser Ser 
            


<210>  334
<211>  243
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - Humanized scFv fragments

<400>  334

Gln Ala Val Val Thr Gln Glu Pro Ser Leu Thr Ser Ser Pro Gly Gly 
1               5                   10                  15      


Thr Val Thr Leu Thr Cys Gly Ser Ser Thr Gly Ala Val Thr Thr Ser 
            20                  25                  30          


Asn Tyr Ala Ser Trp Val Gln Glu Lys Pro Asp His Leu Phe Arg Gly 
        35                  40                  45              


Leu Ile Gly Gly Thr Asn Asn Arg Ala Pro Gly Val Pro Ala Arg Phe 
    50                  55                  60                  


Ser Gly Ser Leu Asp Gly Gly Lys Ala Ala Leu Thr Ile Ser Gly Ala 
65                  70                  75                  80  


Gln Pro Glu Asp Glu Ala Ile Tyr Phe Cys Val Leu Trp Tyr Ser Asp 
                85                  90                  95      


His Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Ser Gly Gly Gly 
            100                 105                 110         


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro 
    130                 135                 140                 


Ser Glu Thr Leu Ser Ile Thr Cys Thr Val Ser Gly Phe Leu Leu Thr 
145                 150                 155                 160 


Asp Tyr Gly Val Asn Trp Val Arg Gln Pro Pro Gly Lys Gly Leu Glu 
                165                 170                 175     


Trp Leu Gly Val Ile Trp Gly Asp Gly Ile Thr Asp Tyr Asn Pro Ser 
            180                 185                 190         


Leu Lys Ser Arg Leu Thr Val Ser Lys Asp Thr Ser Lys Asn Gln Val 
        195                 200                 205             


Ser Leu Lys Met Ser Ser Leu Thr Asp Ala Asp Thr Ala Arg Tyr Tyr 
    210                 215                 220                 


Cys Val Thr Gly Leu Phe Asp Tyr Trp Gly Gln Gly Thr Thr Leu Thr 
225                 230                 235                 240 


Val Ser Ser 
            


<210>  335
<211>  243
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - Humanized scFv fragments

<400>  335

Gln Ala Val Val Thr Gln Glu Pro Ser Leu Thr Ser Ser Pro Gly Gly 
1               5                   10                  15      


Thr Val Thr Leu Thr Cys Arg Ser Ser Thr Gly Ala Val Thr Thr Ser 
            20                  25                  30          


Asn Tyr Ala Ser Trp Val Gln Glu Lys Pro Asp His Leu Phe Arg Gly 
        35                  40                  45              


Leu Ile Gly Gly Thr Asn Asn Arg Ala Pro Gly Val Pro Ala Arg Phe 
    50                  55                  60                  


Ser Gly Ser Leu Leu Gly Gly Lys Ala Ala Leu Thr Ile Ser Gly Ala 
65                  70                  75                  80  


Gln Pro Glu Asp Glu Ala Ile Tyr Phe Cys Val Leu Trp Tyr Ser Asp 
                85                  90                  95      


His Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Gly Gly 
            100                 105                 110         


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro 
    130                 135                 140                 


Ser Glu Thr Leu Ser Ile Thr Cys Thr Val Ser Gly Phe Leu Leu Thr 
145                 150                 155                 160 


Asp Tyr Gly Val Asn Trp Val Arg Gln Pro Pro Gly Lys Gly Leu Glu 
                165                 170                 175     


Trp Leu Gly Val Ile Trp Gly Asp Gly Ile Thr Asp Tyr Asn Pro Ser 
            180                 185                 190         


Leu Lys Ser Arg Leu Thr Val Ser Lys Asp Thr Ser Lys Asn Gln Val 
        195                 200                 205             


Ser Leu Lys Met Ser Ser Leu Thr Ala Ala Asp Thr Ala Arg Tyr Tyr 
    210                 215                 220                 


Cys Val Thr Gly Leu Phe Asp Tyr Trp Gly Gln Gly Thr Thr Leu Thr 
225                 230                 235                 240 


Val Ser Ser 
            


<210>  336
<211>  243
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - Humanized scFv fragments

<400>  336

Gln Ala Val Val Thr Gln Glu Pro Ser Leu Thr Ser Ser Pro Gly Gly 
1               5                   10                  15      


Thr Val Thr Leu Thr Cys Arg Ser Ser Thr Gly Ala Val Thr Thr Ser 
            20                  25                  30          


Asn Tyr Ala Ser Trp Val Gln Glu Lys Pro Asp His Leu Phe Arg Gly 
        35                  40                  45              


Leu Ile Gly Gly Thr Asn Asn Arg Ala Pro Gly Val Pro Ala Arg Phe 
    50                  55                  60                  


Ser Gly Ser Leu Leu Gly Gly Lys Ala Ala Leu Thr Ile Ser Gly Ala 
65                  70                  75                  80  


Gln Pro Glu Asp Glu Ala Ile Tyr Phe Cys Val Leu Trp Tyr Ser Asp 
                85                  90                  95      


His Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Gly Gly 
            100                 105                 110         


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro 
    130                 135                 140                 


Ser Glu Thr Leu Ser Ile Thr Cys Thr Val Ser Gly Phe Leu Leu Thr 
145                 150                 155                 160 


Asp Tyr Gly Val Asn Trp Val Arg Gln Pro Pro Gly Lys Gly Leu Glu 
                165                 170                 175     


Trp Leu Gly Val Ile Trp Gly Asp Gly Ile Thr Asp Tyr Asn Pro Ser 
            180                 185                 190         


Leu Lys Ser Arg Leu Thr Val Ser Lys Asp Thr Ser Lys Asn Gln Val 
        195                 200                 205             


Ser Leu Lys Met Ser Ser Leu Thr Asp Ala Asp Thr Ala Arg Tyr Tyr 
    210                 215                 220                 


Cys Val Thr Gly Leu Phe Asp Tyr Trp Gly Gln Gly Thr Thr Leu Thr 
225                 230                 235                 240 


Val Ser Ser 
            


<210>  337
<211>  243
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - Humanized scFv fragments

<400>  337

Gln Ala Val Val Thr Gln Glu Pro Ser Leu Thr Ser Ser Pro Gly Gly 
1               5                   10                  15      


Thr Val Thr Leu Thr Cys Gly Ser Ser Thr Gly Ala Val Thr Thr Ser 
            20                  25                  30          


Asn Tyr Ala Ser Trp Val Gln Glu Lys Pro Asp His Leu Phe Arg Gly 
        35                  40                  45              


Leu Ile Gly Gly Thr Asn Asn Arg Ala Pro Gly Val Pro Ala Arg Phe 
    50                  55                  60                  


Ser Gly Ser Leu Asp Gly Gly Lys Ala Ala Leu Thr Ile Ser Gly Ala 
65                  70                  75                  80  


Gln Pro Glu Asp Glu Ala Ile Tyr Phe Cys Val Leu Trp Tyr Ser Asp 
                85                  90                  95      


His Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Gly Gly 
            100                 105                 110         


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro 
    130                 135                 140                 


Ser Glu Thr Leu Ser Ile Thr Cys Thr Val Ser Gly Phe Leu Leu Thr 
145                 150                 155                 160 


Asp Tyr Gly Val Asn Trp Val Arg Gln Pro Pro Gly Lys Gly Leu Glu 
                165                 170                 175     


Trp Leu Gly Val Ile Trp Gly Asp Gly Ile Thr Asp Tyr Asn Pro Ser 
            180                 185                 190         


Leu Lys Ser Arg Leu Thr Val Ser Lys Asp Thr Ser Lys Asn Gln Val 
        195                 200                 205             


Ser Leu Lys Met Ser Ser Leu Thr Asp Ala Asp Thr Ala Arg Tyr Tyr 
    210                 215                 220                 


Cys Val Thr Gly Leu Phe Asp Tyr Trp Gly Gln Gly Thr Thr Leu Thr 
225                 230                 235                 240 


Val Ser Ser 
            


<210>  338
<211>  242
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - Humanized scFv fragments

<400>  338

Gln Ala Val Val Thr Gln Glu Pro Ser Leu Thr Val Ser Pro Gly Gly 
1               5                   10                  15      


Thr Val Thr Leu Thr Cys Gly Ser Ser Thr Gly Ala Val Thr Thr Ser 
            20                  25                  30          


Asn Tyr Ala Ser Trp Val Gln Glu Lys Pro Asp His Leu Phe Arg Gly 
        35                  40                  45              


Leu Ile Gly Gly Thr Asn Asn Arg Ala Pro Gly Val Pro Ala Arg Phe 
    50                  55                  60                  


Ser Gly Ser Leu Leu Gly Gly Lys Ala Ala Leu Thr Ile Ser Gly Ala 
65                  70                  75                  80  


Gln Pro Glu Asp Glu Ala Ile Tyr Phe Cys Val Leu Trp Tyr Ser Asp 
                85                  90                  95      


His Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Gly Gly Gly Gly 
            100                 105                 110         


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
        115                 120                 125             


Ser Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser 
    130                 135                 140                 


Glu Thr Leu Ser Ile Thr Cys Thr Val Ser Gly Phe Leu Leu Thr Asp 
145                 150                 155                 160 


Tyr Gly Val Asn Trp Val Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp 
                165                 170                 175     


Leu Gly Val Ile Trp Gly Asp Gly Ile Thr Asp Tyr Asn Pro Ser Leu 
            180                 185                 190         


Lys Ser Arg Leu Thr Val Ser Lys Asp Thr Ser Lys Asn Gln Val Ser 
        195                 200                 205             


Leu Lys Met Ser Ser Leu Thr Ala Ala Asp Thr Ala Arg Tyr Tyr Cys 
    210                 215                 220                 


Val Thr Gly Leu Phe Asp Tyr Trp Gly Gln Gly Thr Thr Leu Thr Val 
225                 230                 235                 240 


Ser Ser 
        


<210>  339
<211>  242
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - Humanized scFv fragments

<400>  339

Gln Ala Val Val Thr Gln Glu Pro Ser Leu Thr Val Ser Pro Gly Gly 
1               5                   10                  15      


Thr Val Thr Leu Thr Cys Gly Ser Ser Thr Gly Ala Val Thr Thr Ser 
            20                  25                  30          


Asn Tyr Ala Ser Trp Val Gln Glu Lys Pro Asp His Leu Phe Arg Gly 
        35                  40                  45              


Leu Ile Gly Gly Thr Asn Asn Arg Ala Pro Gly Val Pro Ala Arg Phe 
    50                  55                  60                  


Ser Gly Ser Leu Leu Gly Gly Lys Ala Ala Leu Thr Ile Ser Gly Ala 
65                  70                  75                  80  


Gln Pro Glu Asp Glu Ala Ile Tyr Phe Cys Val Leu Trp Tyr Ser Asp 
                85                  90                  95      


His Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Gly Gly Gly Gly 
            100                 105                 110         


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
        115                 120                 125             


Ser Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser 
    130                 135                 140                 


Glu Thr Leu Ser Ile Thr Cys Thr Val Ser Gly Phe Leu Leu Thr Asp 
145                 150                 155                 160 


Tyr Gly Val Asn Trp Val Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp 
                165                 170                 175     


Leu Gly Val Ile Trp Gly Asp Gly Ile Thr Asp Tyr Asn Pro Ser Leu 
            180                 185                 190         


Lys Ser Arg Leu Thr Val Ser Lys Asp Thr Ser Lys Asn Gln Val Ser 
        195                 200                 205             


Leu Lys Met Ser Ser Leu Thr Asp Ala Asp Thr Ala Arg Tyr Tyr Cys 
    210                 215                 220                 


Val Thr Gly Leu Phe Asp Tyr Trp Gly Gln Gly Thr Thr Leu Thr Val 
225                 230                 235                 240 


Ser Ser 
        


<210>  340
<211>  243
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - Humanized scFv fragments

<400>  340

Gln Ala Val Val Thr Gln Glu Pro Ser Leu Thr Ser Ser Pro Gly Gly 
1               5                   10                  15      


Thr Val Thr Leu Thr Cys Gly Ser Ser Thr Gly Ala Val Thr Thr Ser 
            20                  25                  30          


Asn Tyr Ala Ser Trp Val Gln Glu Lys Pro Asp His Leu Phe Arg Gly 
        35                  40                  45              


Leu Ile Gly Gly Thr Asn Asn Arg Ala Pro Gly Val Pro Ala Arg Phe 
    50                  55                  60                  


Ser Gly Ser Leu Asp Gly Gly Lys Ala Ala Leu Thr Ile Ser Gly Ala 
65                  70                  75                  80  


Gln Pro Glu Asp Glu Ala Ile Tyr Phe Cys Val Leu Trp Tyr Ser Asp 
                85                  90                  95      


His Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Ser Gly Gly Gly 
            100                 105                 110         


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Asp Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Ala Pro 
    130                 135                 140                 


Ser Gln Ser Leu Ser Ile Thr Cys Thr Val Ser Gly Phe Leu Leu Thr 
145                 150                 155                 160 


Asp Tyr Gly Val Asn Trp Val Arg Gln Ser Pro Gly Lys Gly Leu Glu 
                165                 170                 175     


Trp Leu Gly Val Ile Trp Gly Asp Gly Ile Thr Asp Tyr Asn Ser Ala 
            180                 185                 190         


Leu Lys Ser Arg Leu Ser Val Thr Lys Asp Asn Ser Lys Ser Gln Val 
        195                 200                 205             


Phe Leu Lys Met Asn Ser Leu Gln Ser Gly Asp Ser Ala Arg Tyr Tyr 
    210                 215                 220                 


Cys Val Thr Gly Leu Phe Asp Tyr Trp Gly Gln Gly Thr Thr Leu Thr 
225                 230                 235                 240 


Val Ser Ser 
            


<210>  341
<211>  243
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - Humanized scFv fragments

<400>  341

Gln Ala Val Val Thr Gln Glu Pro Ser Leu Thr Ser Ser Pro Gly Gly 
1               5                   10                  15      


Thr Val Thr Leu Thr Cys Gly Ser Ser Thr Gly Ala Val Thr Thr Ser 
            20                  25                  30          


Asn Tyr Ala Ser Trp Val Gln Glu Lys Pro Asp His Leu Phe Arg Gly 
        35                  40                  45              


Leu Ile Gly Gly Thr Asn Asn Arg Ala Pro Gly Val Pro Ala Arg Phe 
    50                  55                  60                  


Ser Gly Ser Leu Leu Gly Gly Lys Ala Ala Leu Thr Ile Ser Gly Ala 
65                  70                  75                  80  


Gln Pro Glu Asp Glu Ala Ile Tyr Phe Cys Val Leu Trp Tyr Ser Asp 
                85                  90                  95      


His Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Gly Gly 
            100                 105                 110         


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Asp Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Ala Pro 
    130                 135                 140                 


Ser Gln Ser Leu Ser Ile Thr Cys Thr Val Ser Gly Phe Leu Leu Thr 
145                 150                 155                 160 


Asp Tyr Gly Val Asn Trp Val Arg Gln Ser Pro Gly Lys Gly Leu Glu 
                165                 170                 175     


Trp Leu Gly Val Ile Trp Gly Asp Gly Ile Thr Asp Tyr Asn Ser Ala 
            180                 185                 190         


Leu Lys Ser Arg Leu Ser Val Thr Lys Asp Asn Ser Lys Ser Gln Val 
        195                 200                 205             


Phe Leu Lys Met Asn Ser Leu Gln Ser Gly Asp Ser Ala Arg Tyr Tyr 
    210                 215                 220                 


Cys Val Thr Gly Leu Phe Asp Tyr Trp Gly Gln Gly Thr Thr Leu Thr 
225                 230                 235                 240 


Val Ser Ser 
            


<210>  342
<211>  243
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - Humanized scFv fragments

<400>  342

Gln Ala Val Val Thr Gln Glu Pro Ser Leu Thr Ser Ser Pro Gly Gly 
1               5                   10                  15      


Thr Val Thr Leu Thr Cys Gly Ser Ser Thr Gly Ala Val Thr Thr Ser 
            20                  25                  30          


Asn Tyr Ala Ser Trp Val Gln Glu Lys Pro Asp His Leu Phe Arg Gly 
        35                  40                  45              


Leu Ile Gly Gly Thr Asn Asn Arg Ala Pro Gly Val Pro Ala Arg Phe 
    50                  55                  60                  


Ser Gly Ser Leu Leu Gly Gly Lys Ala Ala Leu Thr Ile Ser Gly Ala 
65                  70                  75                  80  


Gln Pro Glu Asp Glu Ala Ile Tyr Phe Cys Val Leu Trp Tyr Ser Asp 
                85                  90                  95      


His Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Gly Gly 
            100                 105                 110         


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Gln Val Gln Leu Gln Gln Ser Gly Pro Gly Leu Val Lys Pro 
    130                 135                 140                 


Ser Glu Thr Leu Ser Ile Thr Cys Thr Val Ser Gly Phe Leu Leu Thr 
145                 150                 155                 160 


Asp Tyr Gly Val Asn Trp Val Arg Gln Pro Pro Gly Lys Gly Leu Glu 
                165                 170                 175     


Trp Leu Gly Val Ile Trp Gly Asp Gly Ile Thr Asp Tyr Asn Pro Ser 
            180                 185                 190         


Leu Lys Ser Arg Leu Thr Val Ser Lys Asp Thr Ser Lys Asn Gln Val 
        195                 200                 205             


Ser Leu Lys Met Ser Ser Leu Thr Ala Ala Asp Thr Ala Arg Tyr Tyr 
    210                 215                 220                 


Cys Val Thr Gly Leu Phe Asp Tyr Trp Gly Gln Gly Thr Thr Leu Thr 
225                 230                 235                 240 


Val Ser Ser 
            


<210>  343
<211>  243
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - Humanized scFv fragments

<400>  343

Gln Ala Val Val Thr Gln Glu Pro Ser Leu Thr Ser Ser Pro Gly Gly 
1               5                   10                  15      


Thr Val Thr Leu Thr Cys Gly Ser Ser Thr Gly Ala Val Thr Thr Ser 
            20                  25                  30          


Asn Tyr Ala Ser Trp Val Gln Glu Lys Pro Asp His Leu Phe Arg Gly 
        35                  40                  45              


Leu Ile Gly Gly Thr Asn Asn Arg Ala Pro Gly Val Pro Ala Arg Phe 
    50                  55                  60                  


Ser Gly Ser Leu Asp Gly Gly Lys Ala Ala Leu Thr Ile Ser Gly Ala 
65                  70                  75                  80  


Gln Pro Glu Asp Glu Ala Ile Tyr Phe Cys Val Leu Trp Tyr Ser Asp 
                85                  90                  95      


His Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Ser Gly Gly Gly 
            100                 105                 110         


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro 
    130                 135                 140                 


Ser Glu Thr Leu Ser Ile Thr Cys Thr Val Ser Gly Phe Leu Leu Thr 
145                 150                 155                 160 


Asp Tyr Gly Val Asn Trp Val Arg Gln Pro Pro Gly Lys Gly Leu Glu 
                165                 170                 175     


Trp Leu Gly Val Ile Trp Gly Asp Gly Ile Thr Asp Tyr Asn Pro Ser 
            180                 185                 190         


Leu Lys Ser Arg Leu Thr Val Ser Lys Asp Thr Ser Lys Asn Gln Val 
        195                 200                 205             


Ser Leu Lys Met Ser Ser Leu Thr Ser Ala Asp Thr Ala Arg Tyr Tyr 
    210                 215                 220                 


Cys Val Thr Gly Leu Phe Asp Tyr Trp Gly Gln Gly Thr Thr Leu Thr 
225                 230                 235                 240 


Val Ser Ser 
            


<210>  344
<211>  243
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - Humanized scFv fragments

<400>  344

Gln Ala Val Val Thr Gln Glu Pro Ser Leu Thr Ser Ser Pro Gly Gly 
1               5                   10                  15      


Thr Val Thr Leu Thr Cys Gly Ser Ser Thr Gly Ala Val Thr Thr Ser 
            20                  25                  30          


Asn Tyr Ala Ser Trp Val Gln Glu Lys Pro Asp His Leu Phe Arg Gly 
        35                  40                  45              


Leu Ile Gly Gly Thr Asn Asn Arg Ala Pro Gly Val Pro Ala Arg Phe 
    50                  55                  60                  


Ser Gly Ser Leu Leu Gly Gly Lys Ala Ala Leu Thr Ile Ser Gly Ala 
65                  70                  75                  80  


Gln Pro Glu Asp Glu Ala Ile Tyr Phe Cys Val Leu Trp Tyr Ser Asp 
                85                  90                  95      


His Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Ser Gly Gly Gly 
            100                 105                 110         


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro 
    130                 135                 140                 


Ser Glu Thr Leu Ser Ile Thr Cys Thr Val Ser Gly Phe Leu Leu Thr 
145                 150                 155                 160 


Asp Tyr Gly Val Asn Trp Val Arg Gln Pro Pro Gly Lys Gly Leu Glu 
                165                 170                 175     


Trp Leu Gly Val Ile Trp Gly Asp Gly Ile Thr Asp Tyr Asn Pro Ser 
            180                 185                 190         


Leu Lys Ser Arg Leu Thr Val Ser Lys Asp Thr Ser Lys Asn Gln Val 
        195                 200                 205             


Ser Leu Lys Met Ser Ser Leu Thr Ala Ala Asp Thr Ala Arg Tyr Tyr 
    210                 215                 220                 


Cys Val Thr Gly Leu Phe Asp Tyr Trp Gly Gln Gly Thr Thr Leu Thr 
225                 230                 235                 240 


Val Ser Ser 
            


<210>  345
<211>  243
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - Humanized scFv fragments

<400>  345

Gln Ala Val Val Thr Gln Glu Pro Ser Leu Thr Ser Ser Pro Gly Gly 
1               5                   10                  15      


Thr Val Thr Leu Thr Cys Gly Ser Ser Thr Gly Ala Val Thr Thr Ser 
            20                  25                  30          


Asn Tyr Ala Ser Trp Val Gln Glu Lys Pro Asp His Leu Phe Arg Gly 
        35                  40                  45              


Leu Ile Gly Gly Thr Asn Asn Arg Ala Pro Gly Val Pro Ala Arg Phe 
    50                  55                  60                  


Ser Gly Ser Leu Leu Gly Gly Lys Ala Ala Leu Thr Ile Ser Gly Ala 
65                  70                  75                  80  


Gln Pro Glu Asp Glu Ala Ile Tyr Phe Cys Val Leu Trp Tyr Ser Asp 
                85                  90                  95      


His Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Gly Gly 
            100                 105                 110         


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro 
    130                 135                 140                 


Ser Glu Thr Leu Ser Ile Thr Cys Thr Val Ser Gly Phe Leu Leu Thr 
145                 150                 155                 160 


Asp Tyr Gly Val Asn Trp Val Arg Gln Pro Pro Gly Lys Gly Leu Glu 
                165                 170                 175     


Trp Leu Gly Val Ile Trp Gly Asp Gly Ile Thr Asp Tyr Asn Pro Ser 
            180                 185                 190         


Leu Lys Ser Arg Leu Thr Val Ser Lys Asp Thr Ser Lys Asn Gln Val 
        195                 200                 205             


Ser Leu Lys Met Ser Ser Leu Thr Ala Ala Asp Thr Ala Arg Tyr Tyr 
    210                 215                 220                 


Cys Val Thr Gly Leu Phe Asp Tyr Trp Gly Gln Gly Thr Thr Leu Thr 
225                 230                 235                 240 


Val Ser Ser 
            


<210>  346
<211>  243
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - Humanized scFv fragments

<400>  346

Gln Ala Val Val Thr Gln Glu Pro Ser Leu Thr Ser Ser Pro Gly Gly 
1               5                   10                  15      


Thr Val Thr Leu Thr Cys Gly Ser Ser Thr Gly Ala Val Thr Thr Ser 
            20                  25                  30          


Asn Tyr Ala Ser Trp Val Gln Glu Lys Pro Asp His Leu Phe Arg Gly 
        35                  40                  45              


Leu Ile Gly Gly Thr Asn Asn Arg Ala Pro Gly Val Pro Ala Arg Phe 
    50                  55                  60                  


Ser Gly Ser Leu Leu Gly Gly Lys Ala Ala Leu Thr Ile Ser Gly Ala 
65                  70                  75                  80  


Gln Pro Glu Asp Glu Ala Ile Tyr Phe Cys Val Leu Trp Tyr Ser Asp 
                85                  90                  95      


His Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Gly Gly 
            100                 105                 110         


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro 
    130                 135                 140                 


Ser Glu Thr Leu Ser Ile Thr Cys Thr Val Ser Gly Phe Leu Leu Thr 
145                 150                 155                 160 


Asp Tyr Gly Val Asn Trp Val Arg Gln Pro Pro Gly Lys Gly Leu Glu 
                165                 170                 175     


Trp Leu Gly Val Ile Trp Gly Asp Gly Ile Thr Asp Tyr Asn Pro Ser 
            180                 185                 190         


Leu Lys Ser Arg Leu Thr Val Ser Lys Asp Thr Ser Lys Asn Gln Val 
        195                 200                 205             


Ser Leu Lys Met Ser Ser Leu Thr Ser Ala Asp Thr Ala Arg Tyr Tyr 
    210                 215                 220                 


Cys Val Thr Gly Leu Phe Asp Tyr Trp Gly Gln Gly Thr Thr Leu Thr 
225                 230                 235                 240 


Val Ser Ser 
            


<210>  347
<211>  243
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - Humanized scFv fragments

<400>  347

Gln Ala Val Val Thr Gln Glu Pro Ser Leu Thr Val Ser Pro Gly Gly 
1               5                   10                  15      


Thr Val Thr Leu Thr Cys Arg Ser Ser Thr Gly Ala Val Thr Thr Ser 
            20                  25                  30          


Asn Tyr Ala Ser Trp Val Gln Glu Lys Pro Asp His Leu Phe Arg Gly 
        35                  40                  45              


Leu Ile Gly Gly Thr Asn Asn Arg Ala Pro Gly Val Pro Ala Arg Phe 
    50                  55                  60                  


Ser Gly Ser Leu Leu Gly Gly Lys Ala Ala Leu Thr Ile Ser Gly Ala 
65                  70                  75                  80  


Gln Pro Glu Asp Glu Ala Ile Tyr Phe Cys Val Leu Trp Tyr Ser Asp 
                85                  90                  95      


His Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Gly Gly 
            100                 105                 110         


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro 
    130                 135                 140                 


Ser Glu Thr Leu Ser Ile Thr Cys Thr Val Ser Gly Phe Leu Leu Thr 
145                 150                 155                 160 


Asp Tyr Gly Val Asn Trp Val Arg Gln Pro Pro Gly Lys Gly Leu Glu 
                165                 170                 175     


Trp Leu Gly Val Ile Trp Gly Asp Gly Ile Thr Asp Tyr Asn Pro Ser 
            180                 185                 190         


Leu Lys Ser Arg Leu Thr Val Ser Lys Asp Thr Ser Lys Asn Gln Val 
        195                 200                 205             


Ser Leu Lys Met Ser Ser Leu Thr Ala Ala Asp Thr Ala Arg Tyr Tyr 
    210                 215                 220                 


Cys Val Thr Gly Leu Phe Asp Tyr Trp Gly Gln Gly Thr Thr Leu Thr 
225                 230                 235                 240 


Val Ser Ser 
            


<210>  348
<211>  243
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - Humanized scFv fragments

<400>  348

Gln Ala Val Val Thr Gln Glu Pro Ser Leu Thr Val Ser Pro Gly Gly 
1               5                   10                  15      


Thr Val Thr Leu Thr Cys Gly Ser Ser Thr Gly Ala Val Thr Thr Ser 
            20                  25                  30          


Asn Tyr Ala Ser Trp Val Gln Glu Lys Pro Asp His Leu Phe Arg Gly 
        35                  40                  45              


Leu Ile Gly Gly Thr Asn Asn Arg Ala Pro Gly Val Pro Ala Arg Phe 
    50                  55                  60                  


Ser Gly Ser Leu Leu Gly Gly Lys Ala Ala Leu Thr Ile Ser Gly Ala 
65                  70                  75                  80  


Gln Pro Glu Asp Glu Ala Ile Tyr Phe Cys Val Leu Trp Tyr Ser Asp 
                85                  90                  95      


His Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Gly Gly 
            100                 105                 110         


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Gln Val Gln Leu Gln Gln Ser Gly Pro Gly Leu Val Lys Pro 
    130                 135                 140                 


Ser Glu Thr Leu Ser Ile Thr Cys Thr Val Ser Gly Phe Ser Leu Thr 
145                 150                 155                 160 


Asp Tyr Gly Val Asn Trp Val Arg Gln Pro Pro Gly Lys Gly Leu Glu 
                165                 170                 175     


Trp Leu Gly Val Ile Trp Gly Asp Gly Ser Thr Asp Tyr Asn Pro Ser 
            180                 185                 190         


Leu Lys Ser Arg Leu Thr Val Ser Lys Asp Asn Ser Lys Asn Gln Val 
        195                 200                 205             


Ser Leu Lys Met Ser Ser Leu Thr Ala Ala Asp Thr Ala Val Tyr Tyr 
    210                 215                 220                 


Cys Val Thr Gly Leu Phe Asp Tyr Trp Gly Gln Gly Thr Leu Leu Thr 
225                 230                 235                 240 


Val Ser Ser 
            


<210>  349
<211>  243
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - Humanized scFv fragments

<400>  349

Gln Ala Val Val Thr Gln Glu Pro Ser Leu Thr Val Ser Pro Gly Gly 
1               5                   10                  15      


Thr Val Thr Leu Thr Cys Gly Ser Ser Thr Gly Ala Val Thr Thr Ser 
            20                  25                  30          


Asn Tyr Ala Ser Trp Val Gln Glu Lys Pro Asp His Leu Phe Arg Gly 
        35                  40                  45              


Leu Ile Gly Gly Thr Asn Asn Arg Ala Pro Gly Val Pro Ala Arg Phe 
    50                  55                  60                  


Ser Gly Ser Leu Leu Gly Gly Lys Ala Ala Leu Thr Ile Ser Gly Ala 
65                  70                  75                  80  


Gln Pro Glu Asp Glu Ala Ile Tyr Phe Cys Val Leu Trp Tyr Ser Asp 
                85                  90                  95      


His Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Gly Gly 
            100                 105                 110         


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Gln Val Gln Leu Gln Gln Ser Gly Pro Gly Leu Val Lys Pro 
    130                 135                 140                 


Ser Glu Thr Leu Ser Ile Thr Cys Thr Val Ser Gly Phe Ser Leu Thr 
145                 150                 155                 160 


Asp Tyr Gly Val Asn Trp Val Arg Gln Pro Pro Gly Lys Gly Leu Glu 
                165                 170                 175     


Trp Leu Gly Val Ile Trp Gly Asp Gly Ser Thr Asp Tyr Asn Pro Ser 
            180                 185                 190         


Leu Lys Ser Arg Leu Thr Val Ser Lys Asp Thr Ser Lys Asn Gln Val 
        195                 200                 205             


Ser Leu Lys Met Ser Ser Leu Thr Ala Ala Asp Thr Ala Val Tyr Tyr 
    210                 215                 220                 


Cys Val Thr Gly Leu Phe Asp Tyr Trp Gly Gln Gly Thr Leu Leu Thr 
225                 230                 235                 240 


Val Ser Ser 
            


<210>  350
<211>  243
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - Humanized scFv fragments

<400>  350

Gln Ala Val Val Thr Gln Glu Pro Ser Leu Thr Val Ser Pro Gly Gly 
1               5                   10                  15      


Thr Val Thr Leu Thr Cys Gly Ser Ser Thr Gly Ala Val Thr Thr Ser 
            20                  25                  30          


Asn Tyr Ala Ser Trp Val Gln Glu Lys Pro Gly Gln Ala Phe Arg Gly 
        35                  40                  45              


Leu Ile Gly Gly Thr Asn Asn Arg Ala Pro Gly Val Pro Ala Arg Phe 
    50                  55                  60                  


Ser Gly Ser Leu Leu Gly Gly Lys Ala Ala Leu Thr Ile Ser Gly Ala 
65                  70                  75                  80  


Gln Pro Glu Asp Glu Ala Ile Tyr Phe Cys Val Leu Trp Tyr Ser Asp 
                85                  90                  95      


His Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Gly Gly 
            100                 105                 110         


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro 
    130                 135                 140                 


Ser Glu Thr Leu Ser Ile Thr Cys Thr Val Ser Gly Phe Leu Leu Thr 
145                 150                 155                 160 


Asp Tyr Gly Val Asn Trp Val Arg Gln Pro Pro Gly Lys Gly Leu Glu 
                165                 170                 175     


Trp Leu Gly Val Ile Trp Gly Asp Gly Ile Thr Asp Tyr Asn Pro Ser 
            180                 185                 190         


Leu Lys Ser Arg Leu Thr Val Ser Lys Asp Thr Ser Lys Asn Gln Val 
        195                 200                 205             


Ser Leu Lys Met Ser Ser Leu Thr Ala Ala Asp Thr Ala Arg Tyr Tyr 
    210                 215                 220                 


Cys Val Thr Gly Leu Phe Asp Tyr Trp Gly Gln Gly Thr Thr Leu Thr 
225                 230                 235                 240 


Val Ser Ser 
            


<210>  351
<211>  243
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - Humanized scFv fragments

<400>  351

Gln Ala Val Val Thr Gln Glu Pro Ser Leu Thr Val Ser Pro Gly Gly 
1               5                   10                  15      


Thr Val Thr Leu Thr Cys Gly Ser Ser Thr Gly Ala Val Thr Thr Ser 
            20                  25                  30          


Asn Tyr Ala Ser Trp Val Gln Glu Lys Pro Gly Gln Ala Phe Arg Gly 
        35                  40                  45              


Leu Ile Gly Gly Thr Asn Asn Arg Ala Pro Gly Val Pro Ala Arg Phe 
    50                  55                  60                  


Ser Gly Ser Leu Leu Gly Gly Lys Ala Ala Leu Thr Ile Ser Gly Ala 
65                  70                  75                  80  


Gln Pro Glu Asp Glu Ala Ile Tyr Phe Cys Val Leu Trp Tyr Ser Asp 
                85                  90                  95      


His Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Gly Gly 
            100                 105                 110         


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Gln Val Gln Leu Gln Gln Ser Gly Pro Gly Leu Val Lys Pro 
    130                 135                 140                 


Ser Glu Thr Leu Ser Ile Thr Cys Thr Val Ser Gly Phe Leu Leu Thr 
145                 150                 155                 160 


Asp Tyr Gly Val Asn Trp Val Arg Gln Pro Pro Gly Lys Gly Leu Glu 
                165                 170                 175     


Trp Leu Gly Val Ile Trp Gly Asp Gly Ile Thr Asp Tyr Asn Pro Ser 
            180                 185                 190         


Leu Lys Ser Arg Leu Thr Val Ser Lys Asp Thr Ser Lys Asn Gln Val 
        195                 200                 205             


Ser Leu Lys Met Ser Ser Leu Thr Ala Ala Asp Thr Ala Arg Tyr Tyr 
    210                 215                 220                 


Cys Val Thr Gly Leu Phe Asp Tyr Trp Gly Gln Gly Thr Thr Leu Thr 
225                 230                 235                 240 


Val Ser Ser 
            


<210>  352
<211>  243
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - Humanized scFv fragments

<400>  352

Gln Ala Val Val Thr Gln Glu Pro Ser Leu Thr Val Ser Pro Gly Gly 
1               5                   10                  15      


Thr Val Thr Leu Thr Cys Gly Ser Ser Thr Gly Ala Val Thr Thr Ser 
            20                  25                  30          


Asn Tyr Ala Ser Trp Val Gln Glu Lys Pro Gly Gln Ala Pro Arg Gly 
        35                  40                  45              


Leu Ile Gly Gly Thr Asn Asn Arg Ala Pro Gly Val Pro Ala Arg Phe 
    50                  55                  60                  


Ser Gly Ser Leu Leu Gly Gly Lys Ala Ala Leu Thr Ile Ser Gly Ala 
65                  70                  75                  80  


Gln Pro Glu Asp Glu Ala Ile Tyr Phe Cys Val Leu Trp Tyr Ser Asp 
                85                  90                  95      


His Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Gly Gly 
            100                 105                 110         


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro 
    130                 135                 140                 


Ser Glu Thr Leu Ser Ile Thr Cys Thr Val Ser Gly Phe Leu Leu Thr 
145                 150                 155                 160 


Asp Tyr Gly Val Asn Trp Val Arg Gln Pro Pro Gly Lys Gly Leu Glu 
                165                 170                 175     


Trp Leu Gly Val Ile Trp Gly Asp Gly Ile Thr Asp Tyr Asn Pro Ser 
            180                 185                 190         


Leu Lys Ser Arg Leu Thr Val Ser Lys Asp Thr Ser Lys Asn Gln Val 
        195                 200                 205             


Ser Leu Lys Met Ser Ser Leu Thr Asp Ala Asp Thr Ala Arg Tyr Tyr 
    210                 215                 220                 


Cys Val Thr Gly Leu Phe Asp Tyr Trp Gly Gln Gly Thr Thr Leu Thr 
225                 230                 235                 240 


Val Ser Ser 
            


<210>  353
<211>  243
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - Humanized scFv fragments

<400>  353

Gln Ala Val Val Thr Gln Glu Pro Ser Leu Thr Val Ser Pro Gly Gly 
1               5                   10                  15      


Thr Val Thr Leu Thr Cys Gly Ser Ser Thr Gly Ala Val Thr Thr Ser 
            20                  25                  30          


Asn Tyr Ala Ser Trp Val Gln Glu Lys Pro Gly Gln Ala Phe Arg Gly 
        35                  40                  45              


Leu Ile Gly Gly Thr Asn Asn Arg Ala Pro Gly Val Pro Ala Arg Phe 
    50                  55                  60                  


Ser Gly Ser Leu Leu Gly Gly Lys Ala Ala Leu Thr Ile Ser Gly Ala 
65                  70                  75                  80  


Gln Pro Glu Asp Glu Ala Ile Tyr Phe Cys Val Leu Trp Tyr Ser Asp 
                85                  90                  95      


His Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Gly Gly 
            100                 105                 110         


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro 
    130                 135                 140                 


Ser Glu Thr Leu Ser Ile Thr Cys Thr Val Ser Gly Phe Leu Leu Thr 
145                 150                 155                 160 


Asp Tyr Gly Val Asn Trp Val Arg Gln Pro Pro Gly Lys Gly Leu Glu 
                165                 170                 175     


Trp Leu Gly Val Ile Trp Gly Asp Gly Ile Thr Asp Tyr Asn Pro Ser 
            180                 185                 190         


Leu Lys Ser Arg Leu Thr Val Ser Lys Asp Thr Ser Lys Asn Gln Val 
        195                 200                 205             


Ser Leu Lys Met Ser Ser Leu Thr Asp Ala Asp Thr Ala Arg Tyr Tyr 
    210                 215                 220                 


Cys Val Thr Gly Leu Phe Asp Tyr Trp Gly Gln Gly Thr Thr Leu Thr 
225                 230                 235                 240 


Val Ser Ser 
            


<210>  354
<211>  243
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - Humanized scFv fragments

<400>  354

Gln Ala Val Val Thr Gln Glu Pro Ser Leu Thr Val Ser Pro Gly Gly 
1               5                   10                  15      


Thr Val Thr Leu Thr Cys Gly Ser Ser Thr Gly Ala Val Thr Thr Ser 
            20                  25                  30          


Asn Tyr Ala Ser Trp Val Gln Glu Lys Pro Gly Gln Ala Pro Arg Gly 
        35                  40                  45              


Leu Ile Gly Gly Thr Asn Asn Arg Ala Pro Gly Val Pro Ala Arg Phe 
    50                  55                  60                  


Ser Gly Ser Leu Leu Gly Gly Lys Ala Ala Leu Thr Ile Ser Gly Ala 
65                  70                  75                  80  


Gln Pro Glu Asp Glu Ala Ile Tyr Phe Cys Val Leu Trp Tyr Ser Asp 
                85                  90                  95      


His Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Gly Gly 
            100                 105                 110         


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Gln Val Gln Leu Gln Gln Ser Gly Pro Gly Leu Val Lys Pro 
    130                 135                 140                 


Ser Glu Thr Leu Ser Ile Thr Cys Thr Val Ser Gly Phe Ser Leu Thr 
145                 150                 155                 160 


Asp Tyr Gly Val Asn Trp Val Arg Gln Pro Pro Gly Lys Gly Leu Glu 
                165                 170                 175     


Trp Leu Gly Val Ile Trp Gly Asp Gly Ser Thr Asp Tyr Asn Pro Ser 
            180                 185                 190         


Leu Lys Ser Arg Leu Thr Val Ser Lys Asp Asn Ser Lys Asn Gln Val 
        195                 200                 205             


Ser Leu Lys Met Ser Ser Leu Thr Ala Ala Asp Thr Ala Val Tyr Tyr 
    210                 215                 220                 


Cys Val Thr Gly Leu Phe Asp Tyr Trp Gly Gln Gly Thr Leu Leu Thr 
225                 230                 235                 240 


Val Ser Ser 
            


<210>  355
<211>  243
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - Humanized scFv fragments

<400>  355

Asp Ala Val Val Thr Gln Glu Ser Ala Leu Thr Thr Ser Pro Gly Glu 
1               5                   10                  15      


Thr Val Thr Leu Thr Cys Arg Ser Ser Thr Gly Ala Val Thr Thr Ser 
            20                  25                  30          


Asn Tyr Ala Asn Trp Val Gln Glu Lys Pro Asp His Leu Phe Thr Gly 
        35                  40                  45              


Leu Ile Gly Gly Thr Asn Asn Arg Ala Pro Gly Val Pro Ala Arg Phe 
    50                  55                  60                  


Ser Gly Ser Leu Ile Gly Asp Lys Ala Ala Leu Thr Ile Thr Gly Ala 
65                  70                  75                  80  


Gln Thr Glu Asp Glu Ala Ile Tyr Phe Cys Ala Leu Trp Tyr Ser Asn 
                85                  90                  95      


His Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Gly Gly 
            100                 105                 110         


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Asp Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Ala Pro 
    130                 135                 140                 


Ser Gln Ser Leu Ser Ile Thr Cys Thr Val Ser Gly Phe Ser Leu Thr 
145                 150                 155                 160 


Asp Tyr Gly Val Asn Trp Val Arg Gln Ser Pro Gly Lys Gly Leu Glu 
                165                 170                 175     


Trp Leu Gly Val Ile Trp Gly Asp Gly Ile Thr Asp Tyr Asn Ser Ala 
            180                 185                 190         


Leu Lys Ser Arg Leu Ser Val Thr Lys Asp Asn Ser Lys Ser Gln Val 
        195                 200                 205             


Phe Leu Lys Met Asn Ser Leu Gln Ser Gly Asp Ser Ala Arg Tyr Tyr 
    210                 215                 220                 


Cys Val Thr Gly Leu Phe Asp Tyr Trp Gly Gln Gly Thr Thr Leu Thr 
225                 230                 235                 240 


Val Ser Ser 
            


<210>  356
<211>  243
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - Humanized scFv fragments

<400>  356

Asp Ala Val Val Thr Gln Glu Ser Ala Leu Thr Ser Ser Pro Gly Glu 
1               5                   10                  15      


Thr Val Thr Leu Thr Cys Arg Ser Ser Thr Gly Ala Val Thr Thr Ser 
            20                  25                  30          


Asn Tyr Ala Ser Trp Val Gln Glu Lys Pro Asp His Leu Phe Thr Gly 
        35                  40                  45              


Leu Ile Gly Gly Thr Asn Asn Arg Ala Pro Gly Val Pro Ala Arg Phe 
    50                  55                  60                  


Ser Gly Ser Leu Ile Gly Asp Lys Ala Ala Leu Thr Ile Thr Gly Ala 
65                  70                  75                  80  


Gln Thr Glu Asp Glu Ala Ile Tyr Phe Cys Val Leu Trp Tyr Ser Asp 
                85                  90                  95      


His Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Gly Gly 
            100                 105                 110         


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro 
    130                 135                 140                 


Ser Glu Thr Leu Ser Ile Thr Cys Thr Val Ser Gly Phe Leu Leu Thr 
145                 150                 155                 160 


Asp Tyr Gly Val Asn Trp Val Arg Gln Pro Pro Gly Lys Gly Leu Glu 
                165                 170                 175     


Trp Leu Gly Val Ile Trp Gly Asp Gly Ile Thr Asp Tyr Asn Pro Ser 
            180                 185                 190         


Leu Lys Ser Arg Leu Thr Val Ser Lys Asp Thr Ser Lys Asn Gln Val 
        195                 200                 205             


Ser Leu Lys Met Ser Ser Leu Thr Asp Ala Asp Thr Ala Arg Tyr Tyr 
    210                 215                 220                 


Cys Val Thr Gly Leu Phe Asp Tyr Trp Gly Gln Gly Thr Thr Leu Thr 
225                 230                 235                 240 


Val Ser Ser 
            


<210>  357
<211>  243
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - Humanized scFv fragments

<400>  357

Asp Ala Val Val Thr Gln Glu Ser Ala Leu Thr Ser Ser Pro Gly Glu 
1               5                   10                  15      


Thr Val Thr Leu Thr Cys Arg Ser Ser Thr Gly Ala Val Thr Thr Ser 
            20                  25                  30          


Asn Tyr Ala Ser Trp Val Gln Glu Lys Pro Asp His Leu Phe Thr Gly 
        35                  40                  45              


Leu Ile Gly Gly Thr Asn Asn Arg Ala Pro Gly Val Pro Ala Arg Phe 
    50                  55                  60                  


Ser Gly Ser Leu Ile Gly Asp Lys Ala Ala Leu Thr Ile Thr Gly Ala 
65                  70                  75                  80  


Gln Thr Glu Asp Glu Ala Ile Tyr Phe Cys Val Leu Trp Tyr Ser Asp 
                85                  90                  95      


His Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Gly Gly 
            100                 105                 110         


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Gln Val Gln Leu Gln Gln Ser Gly Pro Gly Leu Val Lys Pro 
    130                 135                 140                 


Ser Glu Thr Leu Ser Ile Thr Cys Thr Val Ser Gly Phe Leu Leu Thr 
145                 150                 155                 160 


Asp Tyr Gly Val Asn Trp Val Arg Gln Pro Pro Gly Lys Gly Leu Glu 
                165                 170                 175     


Trp Leu Gly Val Ile Trp Gly Asp Gly Ile Thr Asp Tyr Asn Pro Ser 
            180                 185                 190         


Leu Lys Ser Arg Leu Thr Val Ser Lys Asp Thr Ser Lys Asn Gln Val 
        195                 200                 205             


Ser Leu Lys Met Ser Ser Leu Thr Asp Ala Asp Thr Ala Arg Tyr Tyr 
    210                 215                 220                 


Cys Val Thr Gly Leu Phe Asp Tyr Trp Gly Gln Gly Thr Thr Leu Thr 
225                 230                 235                 240 


Val Ser Ser 
            


<210>  358
<211>  243
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - Humanized scFv fragments

<400>  358

Asp Ala Val Val Thr Gln Glu Ser Ala Leu Thr Ser Ser Pro Gly Glu 
1               5                   10                  15      


Thr Val Thr Leu Thr Cys Arg Ser Ser Thr Gly Ala Val Thr Thr Ser 
            20                  25                  30          


Asn Tyr Ala Ser Trp Val Gln Glu Lys Pro Asp His Leu Phe Thr Gly 
        35                  40                  45              


Leu Ile Gly Gly Thr Asn Asn Arg Ala Pro Gly Val Pro Ala Arg Phe 
    50                  55                  60                  


Ser Gly Ser Leu Ile Gly Asp Lys Ala Ala Leu Thr Ile Thr Gly Ala 
65                  70                  75                  80  


Gln Thr Glu Asp Glu Ala Ile Tyr Phe Cys Val Leu Trp Tyr Ser Asp 
                85                  90                  95      


His Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Gly Gly 
            100                 105                 110         


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro 
    130                 135                 140                 


Ser Glu Thr Leu Ser Ile Thr Cys Thr Val Ser Gly Phe Leu Leu Thr 
145                 150                 155                 160 


Asp Tyr Gly Val Asn Trp Val Arg Gln Pro Pro Gly Lys Gly Leu Glu 
                165                 170                 175     


Trp Leu Gly Val Ile Trp Gly Asp Gly Ile Thr Asp Tyr Asn Pro Ser 
            180                 185                 190         


Leu Lys Ser Arg Leu Thr Val Ser Lys Asp Thr Ser Lys Asn Gln Val 
        195                 200                 205             


Ser Leu Lys Met Ser Ser Leu Thr Ser Ala Asp Thr Ala Arg Tyr Tyr 
    210                 215                 220                 


Cys Val Thr Gly Leu Phe Asp Tyr Trp Gly Gln Gly Thr Thr Leu Thr 
225                 230                 235                 240 


Val Ser Ser 
            


<210>  359
<211>  243
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - Humanized scFv fragments

<400>  359

Asp Ala Val Val Thr Gln Glu Ser Ala Leu Thr Ser Ser Pro Gly Glu 
1               5                   10                  15      


Thr Val Thr Leu Thr Cys Arg Ser Ser Thr Gly Ala Val Thr Thr Ser 
            20                  25                  30          


Asn Tyr Ala Ser Trp Val Gln Glu Lys Pro Asp His Leu Phe Thr Gly 
        35                  40                  45              


Leu Ile Gly Gly Thr Asn Asn Arg Ala Pro Gly Val Pro Ala Arg Phe 
    50                  55                  60                  


Ser Gly Ser Leu Ile Gly Asp Lys Ala Ala Leu Thr Ile Thr Gly Ala 
65                  70                  75                  80  


Gln Thr Glu Asp Glu Ala Ile Tyr Phe Cys Val Leu Trp Tyr Ser Asp 
                85                  90                  95      


His Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Gly Gly 
            100                 105                 110         


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro 
    130                 135                 140                 


Ser Glu Thr Leu Ser Ile Thr Cys Thr Val Ser Gly Phe Leu Leu Thr 
145                 150                 155                 160 


Asp Tyr Gly Val Asn Trp Val Arg Gln Pro Pro Gly Lys Gly Leu Glu 
                165                 170                 175     


Trp Leu Gly Val Ile Trp Gly Asp Gly Ile Thr Asp Tyr Asn Pro Ser 
            180                 185                 190         


Leu Lys Ser Arg Leu Thr Val Ser Lys Asp Thr Ser Lys Asn Gln Val 
        195                 200                 205             


Ser Leu Lys Met Ser Ser Leu Thr Ala Ala Asp Thr Ala Arg Tyr Tyr 
    210                 215                 220                 


Cys Val Thr Gly Leu Phe Asp Tyr Trp Gly Gln Gly Thr Thr Leu Thr 
225                 230                 235                 240 


Val Ser Ser 
            


<210>  360
<211>  243
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - Humanized scFv fragments

<400>  360

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Ile Thr Cys Thr Val Ser Gly Phe Leu Leu Thr Asp Tyr 
            20                  25                  30          


Gly Val Asn Trp Val Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Leu 
        35                  40                  45              


Gly Val Ile Trp Gly Asp Gly Ile Thr Asp Tyr Asn Pro Ser Leu Lys 
    50                  55                  60                  


Ser Arg Leu Thr Val Ser Lys Asp Thr Ser Lys Asn Gln Val Ser Leu 
65                  70                  75                  80  


Lys Met Ser Ser Leu Thr Ala Ala Asp Thr Ala Arg Tyr Tyr Cys Val 
                85                  90                  95      


Thr Gly Leu Phe Asp Tyr Trp Gly Gln Gly Thr Thr Leu Thr Val Ser 
            100                 105                 110         


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
        115                 120                 125             


Gly Gly Gly Gly Ser Gln Ala Val Val Thr Gln Glu Pro Ser Leu Thr 
    130                 135                 140                 


Val Ser Pro Gly Gly Thr Val Thr Leu Thr Cys Gly Ser Ser Thr Gly 
145                 150                 155                 160 


Ala Val Thr Thr Ser Asn Tyr Ala Ser Trp Val Gln Glu Lys Pro Asp 
                165                 170                 175     


His Leu Phe Arg Gly Leu Ile Gly Gly Thr Asn Asn Arg Ala Pro Gly 
            180                 185                 190         


Val Pro Ala Arg Phe Ser Gly Ser Leu Leu Gly Gly Lys Ala Ala Leu 
        195                 200                 205             


Thr Ile Ser Gly Ala Gln Pro Glu Asp Glu Ala Ile Tyr Phe Cys Val 
    210                 215                 220                 


Leu Trp Tyr Ser Asp His Trp Val Phe Gly Gly Gly Thr Lys Leu Thr 
225                 230                 235                 240 


Val Leu Gly 
            


<210>  361
<211>  243
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - Humanized scFv fragments

<400>  361

Gln Val Gln Leu Gln Gln Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Ile Thr Cys Thr Val Ser Gly Phe Leu Leu Thr Asp Tyr 
            20                  25                  30          


Gly Val Asn Trp Val Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Leu 
        35                  40                  45              


Gly Val Ile Trp Gly Asp Gly Ile Thr Asp Tyr Asn Pro Ser Leu Lys 
    50                  55                  60                  


Ser Arg Leu Thr Val Ser Lys Asp Thr Ser Lys Asn Gln Val Ser Leu 
65                  70                  75                  80  


Lys Met Ser Ser Leu Thr Ser Ala Asp Thr Ala Arg Tyr Tyr Cys Val 
                85                  90                  95      


Thr Gly Leu Phe Asp Tyr Trp Gly Gln Gly Thr Thr Leu Thr Val Ser 
            100                 105                 110         


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
        115                 120                 125             


Gly Gly Gly Gly Ser Gln Ala Val Val Thr Gln Glu Pro Ser Leu Thr 
    130                 135                 140                 


Val Ser Pro Gly Gly Thr Val Thr Leu Thr Cys Gly Ser Ser Thr Gly 
145                 150                 155                 160 


Ala Val Thr Thr Ser Asn Tyr Ala Ser Trp Val Gln Glu Lys Pro Asp 
                165                 170                 175     


His Leu Phe Arg Gly Leu Ile Gly Gly Thr Asn Asn Arg Ala Pro Gly 
            180                 185                 190         


Val Pro Ala Arg Phe Ser Gly Ser Leu Leu Gly Gly Lys Ala Ala Leu 
        195                 200                 205             


Thr Ile Ser Gly Ala Gln Pro Glu Asp Glu Ala Ile Tyr Phe Cys Val 
    210                 215                 220                 


Leu Trp Tyr Ser Asp His Trp Val Phe Gly Gly Gly Thr Lys Leu Thr 
225                 230                 235                 240 


Val Leu Gly 
            


<210>  362
<211>  243
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - Humanized scFv fragments

<400>  362

Gln Val Gln Leu Gln Gln Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Ile Thr Cys Thr Val Ser Gly Phe Leu Leu Thr Asp Tyr 
            20                  25                  30          


Gly Val Asn Trp Val Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Leu 
        35                  40                  45              


Gly Val Ile Trp Gly Asp Gly Ile Thr Asp Tyr Asn Pro Ser Leu Lys 
    50                  55                  60                  


Ser Arg Leu Thr Val Ser Lys Asp Thr Ser Lys Asn Gln Val Ser Leu 
65                  70                  75                  80  


Lys Met Ser Ser Leu Thr Ser Ala Asp Thr Ala Arg Tyr Tyr Cys Val 
                85                  90                  95      


Thr Gly Leu Phe Asp Tyr Trp Gly Gln Gly Thr Thr Leu Thr Val Ser 
            100                 105                 110         


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
        115                 120                 125             


Gly Gly Gly Gly Ser Gln Ala Val Val Thr Gln Glu Pro Ser Leu Thr 
    130                 135                 140                 


Val Ser Pro Gly Gly Thr Val Thr Leu Thr Cys Arg Ser Ser Thr Gly 
145                 150                 155                 160 


Ala Val Thr Thr Ser Asn Tyr Ala Ser Trp Val Gln Glu Lys Pro Asp 
                165                 170                 175     


His Leu Phe Arg Gly Leu Ile Gly Gly Thr Asn Asn Arg Ala Pro Gly 
            180                 185                 190         


Val Pro Ala Arg Phe Ser Gly Ser Leu Leu Gly Gly Lys Ala Ala Leu 
        195                 200                 205             


Thr Ile Ser Gly Ala Gln Pro Glu Asp Glu Ala Ile Tyr Phe Cys Val 
    210                 215                 220                 


Leu Trp Tyr Ser Asp His Trp Val Phe Gly Gly Gly Thr Lys Leu Thr 
225                 230                 235                 240 


Val Leu Gly 
            


<210>  363
<211>  243
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - Humanized scFv fragments

<400>  363

Gln Val Gln Leu Gln Gln Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Ile Thr Cys Thr Val Ser Gly Phe Ser Leu Thr Asp Tyr 
            20                  25                  30          


Gly Val Asn Trp Val Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Leu 
        35                  40                  45              


Gly Val Ile Trp Gly Asp Gly Ser Thr Asp Tyr Asn Pro Ser Leu Lys 
    50                  55                  60                  


Ser Arg Leu Thr Val Ser Lys Asp Asn Ser Lys Asn Gln Val Ser Leu 
65                  70                  75                  80  


Lys Met Ser Ser Leu Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Val 
                85                  90                  95      


Thr Gly Leu Phe Asp Tyr Trp Gly Gln Gly Thr Leu Leu Thr Val Ser 
            100                 105                 110         


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
        115                 120                 125             


Gly Gly Gly Gly Ser Gln Ala Val Val Thr Gln Glu Pro Ser Leu Thr 
    130                 135                 140                 


Val Ser Pro Gly Gly Thr Val Thr Leu Thr Cys Gly Ser Ser Thr Gly 
145                 150                 155                 160 


Ala Val Thr Thr Ser Asn Tyr Ala Ser Trp Val Gln Gln Lys Pro Gly 
                165                 170                 175     


Gln Ala Pro Arg Gly Leu Ile Gly Gly Thr Asn Asn Arg Ala Pro Gly 
            180                 185                 190         


Val Pro Ala Arg Phe Ser Gly Ser Leu Leu Gly Gly Lys Ala Ala Leu 
        195                 200                 205             


Thr Ile Ser Gly Ala Gln Pro Glu Asp Glu Ala Glu Tyr Tyr Cys Val 
    210                 215                 220                 


Leu Trp Tyr Ser Asp His Trp Val Phe Gly Gly Gly Thr Lys Leu Thr 
225                 230                 235                 240 


Val Leu Gly 
            


<210>  364
<211>  243
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - Humanized scFv fragments

<400>  364

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Ile Thr Cys Thr Val Ser Gly Phe Leu Leu Thr Asp Tyr 
            20                  25                  30          


Gly Val Asn Trp Val Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Leu 
        35                  40                  45              


Gly Val Ile Trp Gly Asp Gly Ile Thr Asp Tyr Asn Pro Ser Leu Lys 
    50                  55                  60                  


Ser Arg Leu Thr Val Ser Lys Asp Asn Ser Lys Asn Gln Val Ser Leu 
65                  70                  75                  80  


Lys Met Ser Ser Leu Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Val 
                85                  90                  95      


Thr Gly Leu Phe Asp Tyr Trp Gly Gln Gly Thr Leu Leu Thr Val Ser 
            100                 105                 110         


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
        115                 120                 125             


Gly Gly Gly Gly Ser Gln Ala Val Val Thr Gln Glu Pro Ser Leu Thr 
    130                 135                 140                 


Val Ser Pro Gly Gly Thr Val Thr Leu Thr Cys Gly Ser Ser Thr Gly 
145                 150                 155                 160 


Ala Val Thr Thr Ser Asn Tyr Ala Ser Trp Val Gln Gln Lys Pro Gly 
                165                 170                 175     


Gln Ala Pro Arg Gly Leu Ile Gly Gly Thr Asn Asn Arg Ala Pro Gly 
            180                 185                 190         


Val Pro Ala Arg Phe Ser Gly Ser Leu Leu Gly Gly Lys Ala Ala Leu 
        195                 200                 205             


Thr Ile Ser Gly Ala Gln Pro Glu Asp Glu Ala Glu Tyr Tyr Cys Val 
    210                 215                 220                 


Leu Trp Tyr Ser Asp His Trp Val Phe Gly Gly Gly Thr Lys Leu Thr 
225                 230                 235                 240 


Val Leu Gly 
            


<210>  365
<211>  243
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - Humanized scFv fragments

<400>  365

Gln Val Gln Leu Gln Gln Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Ile Thr Cys Thr Val Ser Gly Phe Leu Leu Thr Asp Tyr 
            20                  25                  30          


Gly Val Asn Trp Val Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Leu 
        35                  40                  45              


Gly Val Ile Trp Gly Asp Gly Ile Thr Asp Tyr Asn Pro Ser Leu Lys 
    50                  55                  60                  


Ser Arg Leu Thr Val Ser Lys Asp Asn Ser Lys Asn Gln Val Ser Leu 
65                  70                  75                  80  


Lys Met Ser Ser Leu Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Val 
                85                  90                  95      


Thr Gly Leu Phe Asp Tyr Trp Gly Gln Gly Thr Leu Leu Thr Val Ser 
            100                 105                 110         


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
        115                 120                 125             


Gly Gly Gly Gly Ser Gln Ala Val Val Thr Gln Glu Pro Ser Leu Thr 
    130                 135                 140                 


Val Ser Pro Gly Gly Thr Val Thr Leu Thr Cys Gly Ser Ser Thr Gly 
145                 150                 155                 160 


Ala Val Thr Thr Ser Asn Tyr Ala Ser Trp Val Gln Gln Lys Pro Gly 
                165                 170                 175     


Gln Ala Pro Arg Gly Leu Ile Gly Gly Thr Asn Asn Arg Ala Pro Gly 
            180                 185                 190         


Val Pro Ala Arg Phe Ser Gly Ser Leu Leu Gly Gly Lys Ala Ala Leu 
        195                 200                 205             


Thr Ile Ser Gly Ala Gln Pro Glu Asp Glu Ala Glu Tyr Tyr Cys Val 
    210                 215                 220                 


Leu Trp Tyr Ser Asp His Trp Val Phe Gly Gly Gly Thr Lys Leu Thr 
225                 230                 235                 240 


Val Leu Gly 
            


<210>  366
<211>  243
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - Humanized scFv fragments

<400>  366

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Ile Thr Cys Thr Val Ser Gly Phe Leu Leu Thr Asp Tyr 
            20                  25                  30          


Gly Val Asn Trp Val Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Leu 
        35                  40                  45              


Gly Val Ile Trp Gly Asp Gly Ile Thr Asp Tyr Asn Pro Ser Leu Lys 
    50                  55                  60                  


Ser Arg Leu Thr Val Ser Lys Asp Thr Ser Lys Asn Gln Val Ser Leu 
65                  70                  75                  80  


Lys Met Ser Ser Leu Thr Ala Ala Asp Thr Ala Arg Tyr Tyr Cys Val 
                85                  90                  95      


Thr Gly Leu Phe Asp Tyr Trp Gly Gln Gly Thr Thr Leu Thr Val Ser 
            100                 105                 110         


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
        115                 120                 125             


Gly Gly Gly Gly Ser Gln Ala Val Val Thr Gln Glu Pro Ser Leu Thr 
    130                 135                 140                 


Val Ser Pro Gly Gly Thr Val Thr Leu Thr Cys Arg Ser Ser Thr Gly 
145                 150                 155                 160 


Ala Val Thr Thr Ser Asn Tyr Ala Ser Trp Val Gln Glu Lys Pro Asp 
                165                 170                 175     


His Leu Phe Arg Gly Leu Ile Gly Gly Thr Asn Asn Arg Ala Pro Gly 
            180                 185                 190         


Val Pro Ala Arg Phe Ser Gly Ser Leu Leu Gly Gly Lys Ala Ala Leu 
        195                 200                 205             


Thr Ile Ser Gly Ala Gln Pro Glu Asp Glu Ala Ile Tyr Phe Cys Val 
    210                 215                 220                 


Leu Trp Tyr Ser Asp His Trp Val Phe Gly Gly Gly Thr Lys Leu Thr 
225                 230                 235                 240 


Val Leu Gly 
            


<210>  367
<211>  243
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - Humanized scFv fragments

<400>  367

Gln Val Gln Leu Gln Gln Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Ile Thr Cys Thr Val Ser Gly Phe Ser Leu Thr Asp Tyr 
            20                  25                  30          


Gly Val Asn Trp Val Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Leu 
        35                  40                  45              


Gly Val Ile Trp Gly Asp Gly Ser Thr Asp Tyr Asn Pro Ser Leu Lys 
    50                  55                  60                  


Ser Arg Leu Thr Val Ser Lys Asp Asn Ser Lys Asn Gln Val Ser Leu 
65                  70                  75                  80  


Lys Met Ser Ser Leu Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Val 
                85                  90                  95      


Thr Gly Leu Phe Asp Tyr Trp Gly Gln Gly Thr Leu Leu Thr Val Ser 
            100                 105                 110         


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
        115                 120                 125             


Gly Gly Gly Gly Ser Gln Ala Val Val Thr Gln Glu Pro Ser Leu Thr 
    130                 135                 140                 


Val Ser Pro Gly Gly Thr Val Thr Leu Thr Cys Arg Ser Ser Thr Gly 
145                 150                 155                 160 


Ala Val Thr Thr Ser Asn Tyr Ala Ser Trp Val Gln Gln Lys Pro Gly 
                165                 170                 175     


Gln Ala Pro Arg Gly Leu Ile Gly Gly Thr Asn Asn Arg Ala Pro Gly 
            180                 185                 190         


Val Pro Ala Arg Phe Ser Gly Ser Leu Leu Gly Gly Lys Ala Ala Leu 
        195                 200                 205             


Thr Ile Ser Gly Ala Gln Pro Glu Asp Glu Ala Glu Tyr Tyr Cys Val 
    210                 215                 220                 


Leu Trp Tyr Ser Asp His Trp Val Phe Gly Gly Gly Thr Lys Leu Thr 
225                 230                 235                 240 


Val Leu Gly 
            


<210>  368
<211>  243
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - Humanized scFv fragments

<400>  368

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Ile Thr Cys Thr Val Ser Gly Phe Leu Leu Thr Asp Tyr 
            20                  25                  30          


Gly Val Asn Trp Val Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Leu 
        35                  40                  45              


Gly Val Ile Trp Gly Asp Gly Ile Thr Asp Tyr Asn Pro Ser Leu Lys 
    50                  55                  60                  


Ser Arg Leu Thr Val Ser Lys Asp Asn Ser Lys Asn Gln Val Ser Leu 
65                  70                  75                  80  


Lys Met Ser Ser Leu Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Val 
                85                  90                  95      


Thr Gly Leu Phe Asp Tyr Trp Gly Gln Gly Thr Leu Leu Thr Val Ser 
            100                 105                 110         


Ser Gly Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
        115                 120                 125             


Ser Gly Gly Gly Gly Ser Gln Ala Val Val Thr Gln Glu Pro Ser Leu 
    130                 135                 140                 


Thr Val Ser Pro Gly Gly Thr Val Thr Leu Thr Cys Arg Ser Ser Thr 
145                 150                 155                 160 


Gly Ala Val Thr Thr Ser Asn Tyr Ala Ser Trp Val Gln Gln Lys Pro 
                165                 170                 175     


Gly Gln Ala Pro Arg Gly Leu Ile Gly Gly Thr Asn Asn Arg Ala Pro 
            180                 185                 190         


Gly Val Pro Ala Arg Phe Ser Gly Ser Leu Leu Gly Gly Lys Ala Ala 
        195                 200                 205             


Leu Thr Ile Ser Gly Ala Gln Pro Glu Asp Glu Ala Glu Tyr Tyr Cys 
    210                 215                 220                 


Val Leu Trp Tyr Ser Asp His Trp Val Phe Gly Gly Gly Thr Lys Leu 
225                 230                 235                 240 


Thr Val Leu 
            


<210>  369
<211>  243
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - Humanized scFv fragments

<400>  369

Gln Val Gln Leu Gln Gln Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Ile Thr Cys Thr Val Ser Gly Phe Leu Leu Thr Asp Tyr 
            20                  25                  30          


Gly Val Asn Trp Val Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Leu 
        35                  40                  45              


Gly Val Ile Trp Gly Asp Gly Ile Thr Asp Tyr Asn Pro Ser Leu Lys 
    50                  55                  60                  


Ser Arg Leu Thr Val Ser Lys Asp Asn Ser Lys Asn Gln Val Ser Leu 
65                  70                  75                  80  


Lys Met Ser Ser Leu Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Val 
                85                  90                  95      


Thr Gly Leu Phe Asp Tyr Trp Gly Gln Gly Thr Leu Leu Thr Val Ser 
            100                 105                 110         


Ser Gly Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
        115                 120                 125             


Ser Gly Gly Gly Gly Ser Gln Ala Val Val Thr Gln Glu Pro Ser Leu 
    130                 135                 140                 


Thr Val Ser Pro Gly Gly Thr Val Thr Leu Thr Cys Arg Ser Ser Thr 
145                 150                 155                 160 


Gly Ala Val Thr Thr Ser Asn Tyr Ala Ser Trp Val Gln Gln Lys Pro 
                165                 170                 175     


Gly Gln Ala Pro Arg Gly Leu Ile Gly Gly Thr Asn Asn Arg Ala Pro 
            180                 185                 190         


Gly Val Pro Ala Arg Phe Ser Gly Ser Leu Leu Gly Gly Lys Ala Ala 
        195                 200                 205             


Leu Thr Ile Ser Gly Ala Gln Pro Glu Asp Glu Ala Glu Tyr Tyr Cys 
    210                 215                 220                 


Val Leu Trp Tyr Ser Asp His Trp Val Phe Gly Gly Gly Thr Lys Leu 
225                 230                 235                 240 


Thr Val Leu 
            


<210>  370
<211>  243
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - Humanized scFv fragments

<400>  370

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Ile Thr Cys Thr Val Ser Gly Phe Leu Leu Thr Asp Tyr 
            20                  25                  30          


Gly Val Asn Trp Val Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Leu 
        35                  40                  45              


Gly Val Ile Trp Gly Asp Gly Ile Thr Asp Tyr Asn Pro Ser Leu Lys 
    50                  55                  60                  


Ser Arg Leu Thr Val Ser Lys Asp Thr Ser Lys Asn Gln Val Ser Leu 
65                  70                  75                  80  


Lys Met Ser Ser Leu Thr Ser Ala Asp Thr Ala Arg Tyr Tyr Cys Val 
                85                  90                  95      


Thr Gly Leu Phe Asp Tyr Trp Gly Gln Gly Thr Thr Leu Thr Val Ser 
            100                 105                 110         


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
        115                 120                 125             


Gly Gly Gly Gly Ser Gln Ala Val Val Thr Gln Glu Pro Ser Leu Thr 
    130                 135                 140                 


Ser Ser Pro Gly Gly Thr Val Thr Leu Thr Cys Gly Ser Ser Thr Gly 
145                 150                 155                 160 


Ala Val Thr Thr Ser Asn Tyr Ala Ser Trp Val Gln Glu Lys Pro Asp 
                165                 170                 175     


His Leu Phe Arg Gly Leu Ile Gly Gly Thr Asn Asn Arg Ala Pro Gly 
            180                 185                 190         


Val Pro Ala Arg Phe Ser Gly Ser Leu Asp Gly Gly Lys Ala Ala Leu 
        195                 200                 205             


Thr Ile Ser Gly Ala Gln Pro Glu Asp Glu Ala Ile Tyr Phe Cys Val 
    210                 215                 220                 


Leu Trp Tyr Ser Asp His Trp Val Phe Gly Gly Gly Thr Lys Leu Thr 
225                 230                 235                 240 


Val Ser Gly 
            


<210>  371
<211>  243
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - Humanized scFv fragments

<400>  371

Gln Val Gln Leu Gln Gln Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Ile Thr Cys Thr Val Ser Gly Phe Leu Leu Thr Asp Tyr 
            20                  25                  30          


Gly Val Asn Trp Val Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Leu 
        35                  40                  45              


Gly Val Ile Trp Gly Asp Gly Ile Thr Asp Tyr Asn Pro Ser Leu Lys 
    50                  55                  60                  


Ser Arg Leu Thr Val Ser Lys Asp Thr Ser Lys Asn Gln Val Ser Leu 
65                  70                  75                  80  


Lys Met Ser Ser Leu Thr Ala Ala Asp Thr Ala Arg Tyr Tyr Cys Val 
                85                  90                  95      


Thr Gly Leu Phe Asp Tyr Trp Gly Gln Gly Thr Thr Leu Thr Val Ser 
            100                 105                 110         


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
        115                 120                 125             


Gly Gly Gly Gly Ser Gln Ala Val Val Thr Gln Glu Pro Ser Leu Thr 
    130                 135                 140                 


Val Ser Pro Gly Gly Thr Val Thr Leu Thr Cys Gly Ser Ser Thr Gly 
145                 150                 155                 160 


Ala Val Thr Thr Ser Asn Tyr Ala Ser Trp Val Gln Glu Lys Pro Asp 
                165                 170                 175     


His Leu Phe Arg Gly Leu Ile Gly Gly Thr Asn Asn Arg Ala Pro Gly 
            180                 185                 190         


Val Pro Ala Arg Phe Ser Gly Ser Leu Leu Gly Gly Lys Ala Ala Leu 
        195                 200                 205             


Thr Ile Ser Gly Ala Gln Pro Glu Asp Glu Ala Ile Tyr Phe Cys Val 
    210                 215                 220                 


Leu Trp Tyr Ser Asp His Trp Val Phe Gly Gly Gly Thr Lys Leu Thr 
225                 230                 235                 240 


Val Leu Gly 
            


<210>  372
<211>  243
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - Humanized scFv fragments

<400>  372

Gln Val Gln Leu Gln Gln Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Ile Thr Cys Thr Val Ser Gly Phe Leu Leu Thr Asp Tyr 
            20                  25                  30          


Gly Val Asn Trp Val Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Leu 
        35                  40                  45              


Gly Val Ile Trp Gly Asp Gly Ile Thr Asp Tyr Asn Pro Ser Leu Lys 
    50                  55                  60                  


Ser Arg Leu Thr Val Ser Lys Asp Thr Ser Lys Asn Gln Val Ser Leu 
65                  70                  75                  80  


Lys Met Ser Ser Leu Thr Ala Ala Asp Thr Ala Arg Tyr Tyr Cys Val 
                85                  90                  95      


Thr Gly Leu Phe Asp Tyr Trp Gly Gln Gly Thr Thr Leu Thr Val Ser 
            100                 105                 110         


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
        115                 120                 125             


Gly Gly Gly Gly Ser Gln Ala Val Val Thr Gln Glu Pro Ser Leu Thr 
    130                 135                 140                 


Val Ser Pro Gly Gly Thr Val Thr Leu Thr Cys Gly Ser Ser Thr Gly 
145                 150                 155                 160 


Ala Val Thr Thr Ser Asn Tyr Ala Ser Trp Val Gln Glu Lys Pro Asp 
                165                 170                 175     


His Leu Phe Arg Gly Leu Ile Gly Gly Thr Asn Asn Arg Ala Pro Gly 
            180                 185                 190         


Val Pro Ala Arg Phe Ser Gly Ser Leu Leu Gly Gly Lys Ala Ala Leu 
        195                 200                 205             


Thr Ile Ser Gly Ala Gln Pro Glu Asp Glu Ala Ile Tyr Phe Cys Val 
    210                 215                 220                 


Leu Trp Tyr Ser Asp His Trp Val Phe Gly Gly Gly Thr Lys Leu Thr 
225                 230                 235                 240 


Val Asp Gly 
            


<210>  373
<211>  243
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - Humanized scFv fragments

<400>  373

Asp Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Ala Pro Ser Gln 
1               5                   10                  15      


Ser Leu Ser Ile Thr Cys Thr Val Ser Gly Phe Leu Leu Thr Asp Tyr 
            20                  25                  30          


Gly Val Asn Trp Val Arg Gln Ser Pro Gly Lys Gly Leu Glu Trp Leu 
        35                  40                  45              


Gly Val Ile Trp Gly Asp Gly Ile Thr Asp Tyr Asn Ser Ala Leu Lys 
    50                  55                  60                  


Ser Arg Leu Ser Val Thr Lys Asp Asn Ser Lys Ser Gln Val Phe Leu 
65                  70                  75                  80  


Lys Met Asn Ser Leu Gln Ser Gly Asp Ser Ala Arg Tyr Tyr Cys Val 
                85                  90                  95      


Thr Gly Leu Phe Asp Tyr Trp Gly Gln Gly Thr Thr Leu Thr Val Ser 
            100                 105                 110         


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
        115                 120                 125             


Gly Gly Gly Gly Ser Asp Ala Val Val Thr Gln Glu Ser Ala Leu Thr 
    130                 135                 140                 


Ser Ser Pro Gly Glu Thr Val Thr Leu Thr Cys Arg Ser Ser Thr Gly 
145                 150                 155                 160 


Ala Val Thr Thr Ser Asn Tyr Ala Ser Trp Val Gln Glu Lys Pro Asp 
                165                 170                 175     


His Leu Phe Thr Gly Leu Ile Gly Gly Thr Asn Asn Arg Ala Pro Gly 
            180                 185                 190         


Val Pro Ala Arg Phe Ser Gly Ser Leu Ile Gly Asp Lys Ala Ala Leu 
        195                 200                 205             


Thr Ile Thr Gly Ala Gln Thr Glu Asp Glu Ala Ile Tyr Phe Cys Val 
    210                 215                 220                 


Leu Trp Tyr Ser Asp His Trp Val Phe Gly Gly Gly Thr Lys Leu Thr 
225                 230                 235                 240 


Val Leu Gly 
            


<210>  374
<211>  243
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - Humanized scFv fragments

<400>  374

Gln Val Gln Leu Gln Gln Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Ile Thr Cys Thr Val Ser Gly Phe Leu Leu Thr Asp Tyr 
            20                  25                  30          


Gly Val Asn Trp Val Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Leu 
        35                  40                  45              


Gly Val Ile Trp Gly Asp Gly Ile Thr Asp Tyr Asn Pro Ser Leu Lys 
    50                  55                  60                  


Ser Arg Leu Thr Val Ser Lys Asp Thr Ser Lys Asn Gln Val Ser Leu 
65                  70                  75                  80  


Lys Met Ser Ser Leu Thr Ala Ala Asp Thr Ala Arg Tyr Tyr Cys Val 
                85                  90                  95      


Thr Gly Leu Phe Asp Tyr Trp Gly Gln Gly Thr Thr Leu Thr Val Ser 
            100                 105                 110         


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
        115                 120                 125             


Gly Gly Gly Gly Ser Asp Ala Val Val Thr Gln Glu Ser Ala Leu Thr 
    130                 135                 140                 


Ser Ser Pro Gly Glu Thr Val Thr Leu Thr Cys Arg Ser Ser Thr Gly 
145                 150                 155                 160 


Ala Val Thr Thr Ser Asn Tyr Ala Ser Trp Val Gln Glu Lys Pro Asp 
                165                 170                 175     


His Leu Phe Thr Gly Leu Ile Gly Gly Thr Asn Asn Arg Ala Pro Gly 
            180                 185                 190         


Val Pro Ala Arg Phe Ser Gly Ser Leu Ile Gly Asp Lys Ala Ala Leu 
        195                 200                 205             


Thr Ile Thr Gly Ala Gln Thr Glu Asp Glu Ala Ile Tyr Phe Cys Val 
    210                 215                 220                 


Leu Trp Tyr Ser Asp His Trp Val Phe Gly Gly Gly Thr Lys Leu Thr 
225                 230                 235                 240 


Val Leu Gly 
            


<210>  375
<211>  243
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - Humanized scFv fragments

<400>  375

Asp Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Ala Pro Ser Gln 
1               5                   10                  15      


Ser Leu Ser Ile Thr Cys Thr Val Ser Gly Phe Leu Leu Thr Asp Tyr 
            20                  25                  30          


Gly Val Asn Trp Val Arg Gln Ser Pro Gly Lys Gly Leu Glu Trp Leu 
        35                  40                  45              


Gly Val Ile Trp Gly Asp Gly Ile Thr Asp Tyr Asn Ser Ala Leu Lys 
    50                  55                  60                  


Ser Arg Leu Ser Val Thr Lys Asp Asn Ser Lys Ser Gln Val Phe Leu 
65                  70                  75                  80  


Lys Met Asn Ser Leu Gln Ser Gly Asp Ser Ala Arg Tyr Tyr Cys Val 
                85                  90                  95      


Thr Gly Leu Phe Asp Tyr Trp Gly Gln Gly Thr Thr Leu Thr Val Ser 
            100                 105                 110         


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
        115                 120                 125             


Gly Gly Gly Gly Ser Gln Ala Val Val Thr Gln Glu Pro Ser Leu Thr 
    130                 135                 140                 


Val Ser Pro Gly Gly Thr Val Thr Leu Thr Cys Gly Ser Ser Thr Gly 
145                 150                 155                 160 


Ala Val Thr Thr Ser Asn Tyr Ala Ser Trp Val Gln Glu Lys Pro Asp 
                165                 170                 175     


His Leu Phe Arg Gly Leu Ile Gly Gly Thr Asn Asn Arg Ala Pro Gly 
            180                 185                 190         


Val Pro Ala Arg Phe Ser Gly Ser Leu Leu Gly Gly Lys Ala Ala Leu 
        195                 200                 205             


Thr Ile Ser Gly Ala Gln Pro Glu Asp Glu Ala Ile Tyr Phe Cys Val 
    210                 215                 220                 


Leu Trp Tyr Ser Asp His Trp Val Phe Gly Gly Gly Thr Lys Leu Thr 
225                 230                 235                 240 


Val Leu Gly 
            


<210>  376
<211>  245
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - Humanized scFv fragments

<400>  376

Asp Ile Val Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ser Ser Thr Gly Ala Val Thr Thr 
            20                  25                  30          


Ser Asn Tyr Ala Ser Trp Val Gln Glu Lys Pro Gly Lys Leu Phe Lys 
        35                  40                  45              


Gly Leu Ile Gly Gly Thr Asn Asn Arg Ala Pro Gly Val Pro Ser Arg 
    50                  55                  60                  


Phe Ser Gly Ser Leu Ile Gly Asp Lys Ala Thr Leu Thr Ile Ser Ser 
65                  70                  75                  80  


Leu Gln Pro Glu Asp Phe Ala Thr Tyr Phe Cys Ala Leu Trp Tyr Ser 
                85                  90                  95      


Asn His Trp Val Phe Gly Gln Gly Thr Lys Val Glu Leu Lys Arg Gly 
            100                 105                 110         


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
        115                 120                 125             


Gly Gly Gly Ser Glu Val Lys Leu Leu Glu Ser Gly Gly Gly Leu Val 
    130                 135                 140                 


Gln Pro Gly Gly Ser Leu Lys Leu Ser Cys Ala Val Ser Gly Phe Ser 
145                 150                 155                 160 


Leu Thr Asp Tyr Gly Val Asn Trp Val Arg Gln Ala Pro Gly Arg Gly 
                165                 170                 175     


Leu Glu Trp Ile Gly Val Ile Trp Gly Asp Gly Ile Thr Asp Tyr Asn 
            180                 185                 190         


Ser Ala Leu Lys Asp Arg Phe Ile Ile Ser Lys Asp Asn Gly Lys Asn 
        195                 200                 205             


Thr Val Tyr Leu Gln Met Ser Lys Val Arg Ser Asp Asp Thr Ala Leu 
    210                 215                 220                 


Tyr Tyr Cys Val Thr Gly Leu Phe Asp Tyr Trp Gly Gln Gly Thr Leu 
225                 230                 235                 240 


Val Thr Val Ser Ser 
                245 


<210>  377
<211>  245
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - Humanized scFv fragments

<400>  377

Asp Ile Val Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ser Ser Thr Gly Ala Val Thr Thr 
            20                  25                  30          


Ser Asn Tyr Ala Ser Trp Val Gln Glu Lys Pro Gly Lys Leu Phe Lys 
        35                  40                  45              


Gly Leu Ile Gly Gly Thr Asn Asn Arg Ala Pro Gly Val Pro Ser Arg 
    50                  55                  60                  


Phe Ser Gly Ser Leu Ile Gly Asp Lys Ala Thr Leu Thr Ile Ser Ser 
65                  70                  75                  80  


Leu Gln Pro Glu Asp Phe Ala Thr Tyr Phe Cys Ala Leu Trp Tyr Ser 
                85                  90                  95      


Asn His Trp Val Phe Gly Gln Gly Thr Lys Val Glu Leu Lys Arg Gly 
            100                 105                 110         


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
        115                 120                 125             


Gly Gly Gly Ser Glu Val Lys Leu Leu Glu Ser Gly Gly Gly Leu Val 
    130                 135                 140                 


Gln Pro Gly Gly Ser Leu Lys Leu Ser Cys Ala Val Ser Gly Phe Ser 
145                 150                 155                 160 


Leu Thr Asp Tyr Gly Val Asn Trp Val Arg Gln Ala Pro Gly Arg Gly 
                165                 170                 175     


Leu Glu Trp Ile Gly Val Ile Trp Gly Asp Gly Ile Thr Asp Tyr Asn 
            180                 185                 190         


Ser Ala Leu Lys Asp Arg Phe Ile Ile Ser Lys Asp Asp Cys Glu Asn 
        195                 200                 205             


Thr Val Tyr Leu Gln Met Ser Lys Val Arg Ser Asp Asp Thr Ala Leu 
    210                 215                 220                 


Tyr Tyr Cys Val Thr Gly Leu Phe Asp Tyr Trp Gly Gln Gly Thr Leu 
225                 230                 235                 240 


Val Thr Val Ser Ser 
                245 


<210>  378
<211>  245
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - Humanized scFv fragments

<400>  378

Asp Ile Val Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ser Ser Thr Gly Ala Val Thr Thr 
            20                  25                  30          


Ser Asn Tyr Ala Ser Trp Val Gln Glu Lys Pro Gly Lys Leu Phe Lys 
        35                  40                  45              


Gly Leu Ile Gly Gly Thr Asn Asn Arg Ala Pro Gly Val Pro Ser Arg 
    50                  55                  60                  


Phe Ser Gly Ser Leu Ile Gly Asp Lys Ala Thr Leu Thr Ile Ser Ser 
65                  70                  75                  80  


Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Ala Leu Trp Tyr Ser 
                85                  90                  95      


Asn His Trp Val Phe Gly Gln Gly Thr Lys Val Glu Leu Lys Arg Gly 
            100                 105                 110         


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
        115                 120                 125             


Gly Gly Gly Ser Glu Val Lys Leu Leu Glu Ser Gly Gly Gly Leu Val 
    130                 135                 140                 


Gln Pro Gly Gly Ser Leu Lys Leu Ser Cys Ala Val Ser Gly Phe Ser 
145                 150                 155                 160 


Leu Thr Asp Tyr Gly Val Asn Trp Val Arg Gln Ala Pro Gly Arg Gly 
                165                 170                 175     


Leu Glu Trp Ile Gly Val Ile Trp Gly Asp Gly Thr Thr Asp Tyr Asn 
            180                 185                 190         


Ser Ala Leu Lys Asp Arg Phe Ile Ile Ser Lys Asp Asp Cys Glu Asn 
        195                 200                 205             


Thr Val Tyr Leu Gln Met Ser Lys Val Arg Ser Asp Asp Thr Ala Leu 
    210                 215                 220                 


Tyr Tyr Cys Val Thr Gly Leu Phe Asp Tyr Trp Gly Gln Gly Thr Leu 
225                 230                 235                 240 


Val Thr Val Ser Ser 
                245 


<210>  379
<211>  245
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - Humanized scFv fragments

<400>  379

Asp Ile Val Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ser Ser Thr Gly Ala Val Thr Thr 
            20                  25                  30          


Ser Asn Tyr Ala Ser Trp Val Gln Glu Lys Pro Gly Lys Leu Phe Lys 
        35                  40                  45              


Gly Leu Ile Gly Gly Thr Asn Asn Arg Ala Pro Gly Val Pro Ser Arg 
    50                  55                  60                  


Phe Ser Gly Ser Leu Ile Gly Asp Lys Ala Thr Leu Thr Ile Ser Ser 
65                  70                  75                  80  


Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Ala Leu Trp Tyr Ser 
                85                  90                  95      


Asn His Trp Val Phe Gly Gln Gly Thr Lys Val Glu Leu Lys Arg Gly 
            100                 105                 110         


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
        115                 120                 125             


Gly Gly Gly Ser Glu Val Lys Leu Leu Glu Ser Gly Gly Gly Leu Val 
    130                 135                 140                 


Gln Pro Gly Gly Ser Leu Lys Leu Ser Cys Ala Val Ser Gly Phe Ser 
145                 150                 155                 160 


Leu Thr Asp Tyr Gly Val Asn Trp Val Arg Gln Ala Pro Gly Arg Gly 
                165                 170                 175     


Leu Glu Trp Ile Gly Val Ile Trp Gly Asp Gly Thr Thr Asp Tyr Asn 
            180                 185                 190         


Ser Ala Leu Lys Asp Arg Phe Ile Ile Ser Lys Asp Asp Ser Glu Asn 
        195                 200                 205             


Thr Val Tyr Leu Gln Met Ser Lys Val Arg Ser Asp Asp Thr Ala Leu 
    210                 215                 220                 


Tyr Tyr Cys Val Thr Gly Leu Phe Asp Tyr Trp Gly Gln Gly Thr Leu 
225                 230                 235                 240 


Val Thr Val Ser Ser 
                245 


<210>  380
<211>  243
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - Humanized scFv fragments

<400>  380

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ser Ser Thr Gly Ala Val Thr Thr 
            20                  25                  30          


Ser Asn Tyr Ala Ser Trp Val Gln Gln Lys Pro Gly Lys Ala Phe Lys 
        35                  40                  45              


Gly Leu Ile Gly Gly Thr Asn Asn Arg Ala Pro Gly Val Pro Ser Arg 
    50                  55                  60                  


Phe Ser Gly Ser Gly Ser Gly Thr Asp Ala Thr Leu Thr Ile Ser Ser 
65                  70                  75                  80  


Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Ala Leu Trp Tyr Ser 
                85                  90                  95      


Asn His Trp Val Phe Gly Gln Gly Thr Lys Val Glu Leu Lys Gly Gly 
            100                 105                 110         


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ser Gly Gly 
        115                 120                 125             


Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro 
    130                 135                 140                 


Gly Gly Ser Leu Arg Leu Ser Cys Ala Val Ser Gly Phe Ser Leu Thr 
145                 150                 155                 160 


Asp Tyr Gly Val Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu 
                165                 170                 175     


Trp Ile Gly Val Ile Trp Gly Asp Gly Thr Thr Asp Tyr Ala Asp Ser 
            180                 185                 190         


Leu Lys Gly Arg Phe Thr Ile Ser Lys Asp Asp Ser Lys Asn Thr Val 
        195                 200                 205             


Tyr Leu Gln Met Asn Ser Val Arg Ala Glu Asp Thr Ala Val Tyr Tyr 
    210                 215                 220                 


Cys Val Thr Gly Leu Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr 
225                 230                 235                 240 


Val Ser Ser 
            


<210>  381
<211>  243
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - Humanized scFv fragments

<400>  381

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ser Ser Thr Gly Ala Val Thr Thr 
            20                  25                  30          


Ser Asn Tyr Ala Ser Trp Val Gln Gln Lys Pro Gly Lys Ala Phe Lys 
        35                  40                  45              


Gly Leu Ile Gly Gly Thr Asn Asn Arg Ala Pro Gly Val Pro Ser Arg 
    50                  55                  60                  


Phe Ser Gly Ser Leu Ile Gly Asp Lys Ala Thr Leu Thr Ile Ser Ser 
65                  70                  75                  80  


Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Ala Leu Trp Tyr Ser 
                85                  90                  95      


Asn His Trp Val Phe Gly Gln Gly Thr Lys Val Glu Leu Lys Gly Gly 
            100                 105                 110         


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ser Gly Gly 
        115                 120                 125             


Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro 
    130                 135                 140                 


Gly Gly Ser Leu Arg Leu Ser Cys Ala Val Ser Gly Phe Ser Leu Thr 
145                 150                 155                 160 


Asp Tyr Gly Val Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu 
                165                 170                 175     


Trp Ile Gly Val Ile Trp Gly Asp Gly Thr Thr Asp Tyr Ala Asp Ser 
            180                 185                 190         


Leu Lys Gly Arg Phe Thr Ile Ser Lys Asp Asp Ser Lys Asn Thr Val 
        195                 200                 205             


Tyr Leu Gln Met Asn Ser Val Arg Ala Glu Asp Thr Ala Val Tyr Tyr 
    210                 215                 220                 


Cys Val Thr Gly Leu Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr 
225                 230                 235                 240 


Val Ser Ser 
            


<210>  382
<211>  243
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - Humanized scFv fragments

<400>  382

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ser Ser Thr Gly Ala Val Thr Thr 
            20                  25                  30          


Ser Asn Tyr Ala Ser Trp Val Gln Gln Lys Pro Gly Lys Ala Phe Lys 
        35                  40                  45              


Gly Leu Ile Gly Gly Thr Asn Asn Arg Ala Pro Gly Val Pro Ser Arg 
    50                  55                  60                  


Phe Ser Gly Ser Leu Leu Gly Gly Lys Ala Thr Leu Thr Ile Ser Ser 
65                  70                  75                  80  


Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Ala Leu Trp Tyr Ser 
                85                  90                  95      


Asn His Trp Val Phe Gly Gln Gly Thr Lys Val Glu Leu Lys Gly Gly 
            100                 105                 110         


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ser Gly Gly 
        115                 120                 125             


Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro 
    130                 135                 140                 


Gly Gly Ser Leu Arg Leu Ser Cys Ala Val Ser Gly Phe Ser Leu Thr 
145                 150                 155                 160 


Asp Tyr Gly Val Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu 
                165                 170                 175     


Trp Ile Gly Val Ile Trp Gly Asp Gly Thr Thr Asp Tyr Ala Asp Ser 
            180                 185                 190         


Leu Lys Gly Arg Phe Thr Ile Ser Lys Asp Asp Ser Lys Asn Thr Val 
        195                 200                 205             


Tyr Leu Gln Met Asn Ser Val Arg Ala Glu Asp Thr Ala Val Tyr Tyr 
    210                 215                 220                 


Cys Val Thr Gly Leu Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr 
225                 230                 235                 240 


Val Ser Ser 
            


<210>  383
<211>  243
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - Humanized scFv fragments

<400>  383

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ser Ser Thr Gly Ala Val Thr Thr 
            20                  25                  30          


Ser Asn Tyr Ala Ser Trp Val Gln Gln Lys Pro Gly Lys Ala Phe Lys 
        35                  40                  45              


Gly Leu Ile Gly Gly Thr Asn Asn Arg Ala Pro Gly Val Pro Ser Arg 
    50                  55                  60                  


Phe Ser Gly Ser Leu Ser Gly Gly Lys Ala Thr Leu Thr Ile Ser Ser 
65                  70                  75                  80  


Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Ala Leu Trp Tyr Ser 
                85                  90                  95      


Asn His Trp Val Phe Gly Gln Gly Thr Lys Val Glu Leu Lys Gly Gly 
            100                 105                 110         


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ser Gly Gly 
        115                 120                 125             


Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro 
    130                 135                 140                 


Gly Gly Ser Leu Arg Leu Ser Cys Ala Val Ser Gly Phe Ser Leu Thr 
145                 150                 155                 160 


Asp Tyr Gly Val Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu 
                165                 170                 175     


Trp Ile Gly Val Ile Trp Gly Asp Gly Thr Thr Asp Tyr Ala Asp Ser 
            180                 185                 190         


Leu Lys Gly Arg Phe Thr Ile Ser Lys Asp Asp Ser Lys Asn Thr Val 
        195                 200                 205             


Tyr Leu Gln Met Asn Ser Val Arg Ala Glu Asp Thr Ala Val Tyr Tyr 
    210                 215                 220                 


Cys Val Thr Gly Leu Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr 
225                 230                 235                 240 


Val Ser Ser 
            


<210>  384
<211>  243
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - Humanized scFv fragments

<400>  384

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ser Ser Thr Gly Ala Val Thr Thr 
            20                  25                  30          


Ser Asn Tyr Ala Ser Trp Val Gln Gln Lys Pro Gly Lys Ala Phe Lys 
        35                  40                  45              


Gly Leu Ile Gly Gly Thr Asn Asn Arg Ala Pro Gly Val Pro Ser Arg 
    50                  55                  60                  


Phe Ser Gly Ser Gly Ser Gly Thr Asp Ala Thr Leu Thr Ile Ser Ser 
65                  70                  75                  80  


Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Ala Leu Trp Tyr Ser 
                85                  90                  95      


Asn His Trp Val Phe Gly Gln Gly Thr Lys Val Glu Leu Lys Gly Gly 
            100                 105                 110         


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ser Gly Gly 
        115                 120                 125             


Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro 
    130                 135                 140                 


Gly Gly Ser Leu Arg Leu Ser Cys Ala Val Ser Gly Phe Ser Leu Thr 
145                 150                 155                 160 


Asp Tyr Gly Val Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu 
                165                 170                 175     


Trp Leu Gly Val Ile Trp Gly Asp Gly Thr Thr Asp Tyr Ala Asp Ser 
            180                 185                 190         


Leu Lys Gly Arg Phe Thr Ile Ser Lys Asp Asn Ser Lys Asn Thr Val 
        195                 200                 205             


Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr 
    210                 215                 220                 


Cys Val Thr Gly Leu Phe Asp Tyr Trp Gly Gln Gly Thr Leu Leu Thr 
225                 230                 235                 240 


Val Ser Ser 
            


<210>  385
<211>  243
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - Humanized scFv fragments

<400>  385

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ser Ser Thr Gly Ala Val Thr Thr 
            20                  25                  30          


Ser Asn Tyr Ala Ser Trp Val Gln Gln Lys Pro Gly Lys Ala Phe Lys 
        35                  40                  45              


Gly Leu Ile Gly Gly Thr Asn Asn Arg Ala Pro Gly Val Pro Ser Arg 
    50                  55                  60                  


Phe Ser Gly Ser Leu Ile Gly Asp Lys Ala Thr Leu Thr Ile Ser Ser 
65                  70                  75                  80  


Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Ala Leu Trp Tyr Ser 
                85                  90                  95      


Asn His Trp Val Phe Gly Gln Gly Thr Lys Val Glu Leu Lys Gly Gly 
            100                 105                 110         


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ser Gly Gly 
        115                 120                 125             


Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro 
    130                 135                 140                 


Gly Gly Ser Leu Arg Leu Ser Cys Ala Val Ser Gly Phe Ser Leu Thr 
145                 150                 155                 160 


Asp Tyr Gly Val Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu 
                165                 170                 175     


Trp Leu Gly Val Ile Trp Gly Asp Gly Thr Thr Asp Tyr Ala Asp Ser 
            180                 185                 190         


Leu Lys Gly Arg Phe Thr Ile Ser Lys Asp Asn Ser Lys Asn Thr Val 
        195                 200                 205             


Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr 
    210                 215                 220                 


Cys Val Thr Gly Leu Phe Asp Tyr Trp Gly Gln Gly Thr Leu Leu Thr 
225                 230                 235                 240 


Val Ser Ser 
            


<210>  386
<211>  243
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - Humanized scFv fragments

<400>  386

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ser Ser Thr Gly Ala Val Thr Thr 
            20                  25                  30          


Ser Asn Tyr Ala Ser Trp Val Gln Gln Lys Pro Gly Lys Ala Phe Lys 
        35                  40                  45              


Gly Leu Ile Gly Gly Thr Asn Asn Arg Ala Pro Gly Val Pro Ser Arg 
    50                  55                  60                  


Phe Ser Gly Ser Leu Leu Gly Gly Lys Ala Thr Leu Thr Ile Ser Ser 
65                  70                  75                  80  


Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Ala Leu Trp Tyr Ser 
                85                  90                  95      


Asn His Trp Val Phe Gly Gln Gly Thr Lys Val Glu Leu Lys Gly Gly 
            100                 105                 110         


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ser Gly Gly 
        115                 120                 125             


Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro 
    130                 135                 140                 


Gly Gly Ser Leu Arg Leu Ser Cys Ala Val Ser Gly Phe Ser Leu Thr 
145                 150                 155                 160 


Asp Tyr Gly Val Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu 
                165                 170                 175     


Trp Leu Gly Val Ile Trp Gly Asp Gly Thr Thr Asp Tyr Ala Asp Ser 
            180                 185                 190         


Leu Lys Gly Arg Phe Thr Ile Ser Lys Asp Asn Ser Lys Asn Thr Val 
        195                 200                 205             


Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr 
    210                 215                 220                 


Cys Val Thr Gly Leu Phe Asp Tyr Trp Gly Gln Gly Thr Leu Leu Thr 
225                 230                 235                 240 


Val Ser Ser 
            


<210>  387
<211>  243
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - Humanized scFv fragments

<400>  387

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ser Ser Thr Gly Ala Val Thr Thr 
            20                  25                  30          


Ser Asn Tyr Ala Ser Trp Val Gln Gln Lys Pro Gly Lys Ala Phe Lys 
        35                  40                  45              


Gly Leu Ile Gly Gly Thr Asn Asn Arg Ala Pro Gly Val Pro Ser Arg 
    50                  55                  60                  


Phe Ser Gly Ser Leu Ser Gly Gly Lys Ala Thr Leu Thr Ile Ser Ser 
65                  70                  75                  80  


Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Ala Leu Trp Tyr Ser 
                85                  90                  95      


Asn His Trp Val Phe Gly Gln Gly Thr Lys Val Glu Leu Lys Gly Gly 
            100                 105                 110         


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ser Gly Gly 
        115                 120                 125             


Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro 
    130                 135                 140                 


Gly Gly Ser Leu Arg Leu Ser Cys Ala Val Ser Gly Phe Ser Leu Thr 
145                 150                 155                 160 


Asp Tyr Gly Val Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu 
                165                 170                 175     


Trp Leu Gly Val Ile Trp Gly Asp Gly Thr Thr Asp Tyr Ala Asp Ser 
            180                 185                 190         


Leu Lys Gly Arg Phe Thr Ile Ser Lys Asp Asn Ser Lys Asn Thr Val 
        195                 200                 205             


Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr 
    210                 215                 220                 


Cys Val Thr Gly Leu Phe Asp Tyr Trp Gly Gln Gly Thr Leu Leu Thr 
225                 230                 235                 240 


Val Ser Ser 
            


<210>  388
<211>  243
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - Humanized scFv fragments

<400>  388

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ser Leu Thr Asp Tyr 
            20                  25                  30          


Gly Val Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Val Ile Trp Gly Asp Gly Thr Thr Asp Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Gly Leu Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser 
            100                 105                 110         


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
        115                 120                 125             


Ser Gly Gly Gly Ser Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu 
    130                 135                 140                 


Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ser Ser Thr 
145                 150                 155                 160 


Gly Ala Val Thr Thr Ser Asn Tyr Ala Ser Trp Tyr Gln Gln Lys Pro 
                165                 170                 175     


Gly Lys Ala Pro Lys Leu Leu Ile Tyr Gly Thr Asn Asn Arg Ala Pro 
            180                 185                 190         


Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr 
        195                 200                 205             


Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys 
    210                 215                 220                 


Ala Leu Trp Tyr Ser Asn His Trp Val Phe Gly Gln Gly Thr Lys Val 
225                 230                 235                 240 


Glu Ile Lys 
            


<210>  389
<211>  434
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - CAR construct

<400>  389

Asp Ala Val Val Thr Gln Glu Ser Ala Leu Thr Ser Ser Pro Gly Glu 
1               5                   10                  15      


Thr Val Thr Leu Thr Cys Arg Ser Ser Thr Gly Ala Val Thr Thr Ser 
            20                  25                  30          


Asn Tyr Ala Ser Trp Val Gln Glu Lys Pro Asp His Leu Phe Thr Gly 
        35                  40                  45              


Leu Ile Gly Gly Thr Asn Asn Arg Ala Pro Gly Val Pro Ala Arg Phe 
    50                  55                  60                  


Ser Gly Ser Leu Ile Gly Asp Lys Ala Ala Leu Thr Ile Thr Gly Ala 
65                  70                  75                  80  


Gln Thr Glu Asp Glu Ala Ile Tyr Phe Cys Val Leu Trp Tyr Ser Asp 
                85                  90                  95      


His Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Gly Gly 
            100                 105                 110         


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Asp Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Ala Pro 
    130                 135                 140                 


Ser Gln Ser Leu Ser Ile Thr Cys Thr Val Ser Gly Phe Leu Leu Thr 
145                 150                 155                 160 


Asp Tyr Gly Val Asn Trp Val Arg Gln Ser Pro Gly Lys Gly Leu Glu 
                165                 170                 175     


Trp Leu Gly Val Ile Trp Gly Asp Gly Ile Thr Asp Tyr Asn Ser Ala 
            180                 185                 190         


Leu Lys Ser Arg Leu Ser Val Thr Lys Asp Asn Ser Lys Ser Gln Val 
        195                 200                 205             


Phe Leu Lys Met Asn Ser Leu Gln Ser Gly Asp Ser Ala Arg Tyr Tyr 
    210                 215                 220                 


Cys Val Thr Gly Leu Phe Asp Tyr Trp Gly Gln Gly Thr Thr Leu Thr 
225                 230                 235                 240 


Val Ser Ser Glu Ser Lys Tyr Gly Pro Pro Cys Pro Pro Cys Pro Asp 
                245                 250                 255     


Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu 
            260                 265                 270         


Ser Leu Val Ile Thr Leu Tyr Cys Lys Arg Gly Arg Lys Lys Leu Leu 
        275                 280                 285             


Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu 
    290                 295                 300                 


Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys 
305                 310                 315                 320 


Glu Leu Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Lys 
                325                 330                 335     


Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu 
            340                 345                 350         


Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly 
        355                 360                 365             


Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu 
    370                 375                 380                 


Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly 
385                 390                 395                 400 


Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser 
                405                 410                 415     


Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro 
            420                 425                 430         


Pro Arg 
        


<210>  390
<211>  437
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - CAR construct

<400>  390

Asp Ala Val Val Thr Gln Glu Ser Ala Leu Thr Ser Ser Pro Gly Glu 
1               5                   10                  15      


Thr Val Thr Leu Thr Cys Arg Ser Ser Thr Gly Ala Val Thr Thr Ser 
            20                  25                  30          


Asn Tyr Ala Ser Trp Val Gln Glu Lys Pro Asp His Leu Phe Thr Gly 
        35                  40                  45              


Leu Ile Gly Gly Thr Asn Asn Arg Ala Pro Gly Val Pro Ala Arg Phe 
    50                  55                  60                  


Ser Gly Ser Leu Ile Gly Asp Lys Ala Ala Leu Thr Ile Thr Gly Ala 
65                  70                  75                  80  


Gln Thr Glu Asp Glu Ala Ile Tyr Phe Cys Val Leu Trp Tyr Ser Asp 
                85                  90                  95      


His Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Gly Gly 
            100                 105                 110         


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Asp Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Ala Pro 
    130                 135                 140                 


Ser Gln Ser Leu Ser Ile Thr Cys Thr Val Ser Gly Phe Leu Leu Thr 
145                 150                 155                 160 


Asp Tyr Gly Val Asn Trp Val Arg Gln Ser Pro Gly Lys Gly Leu Glu 
                165                 170                 175     


Trp Leu Gly Val Ile Trp Gly Asp Gly Ile Thr Asp Tyr Asn Ser Ala 
            180                 185                 190         


Leu Lys Ser Arg Leu Ser Val Thr Lys Asp Asn Ser Lys Ser Gln Val 
        195                 200                 205             


Phe Leu Lys Met Asn Ser Leu Gln Ser Gly Asp Ser Ala Arg Tyr Tyr 
    210                 215                 220                 


Cys Val Thr Gly Leu Phe Asp Tyr Trp Gly Gln Gly Thr Thr Leu Thr 
225                 230                 235                 240 


Val Ser Ser Glu Ser Lys Tyr Gly Pro Pro Cys Pro Pro Cys Pro Asp 
                245                 250                 255     


Phe Trp Val Leu Val Val Val Gly Gly Val Leu Ala Cys Tyr Ser Leu 
            260                 265                 270         


Leu Val Thr Val Ala Phe Ile Ile Phe Trp Val Lys Arg Gly Arg Lys 
        275                 280                 285             


Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro Val Gln Thr 
    290                 295                 300                 


Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu 
305                 310                 315                 320 


Gly Gly Cys Glu Leu Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro 
                325                 330                 335     


Ala Tyr Lys Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly 
            340                 345                 350         


Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro 
        355                 360                 365             


Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr 
    370                 375                 380                 


Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly 
385                 390                 395                 400 


Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln 
                405                 410                 415     


Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln 
            420                 425                 430         


Ala Leu Pro Pro Arg 
        435         


<210>  391
<211>  436
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - CAR construct

<400>  391

Asp Ala Val Val Thr Gln Glu Ser Ala Leu Thr Ser Ser Pro Gly Glu 
1               5                   10                  15      


Thr Val Thr Leu Thr Cys Arg Ser Ser Thr Gly Ala Val Thr Thr Ser 
            20                  25                  30          


Asn Tyr Ala Ser Trp Val Gln Glu Lys Pro Asp His Leu Phe Thr Gly 
        35                  40                  45              


Leu Ile Gly Gly Thr Asn Asn Arg Ala Pro Gly Val Pro Ala Arg Phe 
    50                  55                  60                  


Ser Gly Ser Leu Ile Gly Asp Lys Ala Ala Leu Thr Ile Thr Gly Ala 
65                  70                  75                  80  


Gln Thr Glu Asp Glu Ala Ile Tyr Phe Cys Val Leu Trp Tyr Ser Asp 
                85                  90                  95      


His Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Gly Gly 
            100                 105                 110         


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Asp Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Ala Pro 
    130                 135                 140                 


Ser Gln Ser Leu Ser Ile Thr Cys Thr Val Ser Gly Phe Leu Leu Thr 
145                 150                 155                 160 


Asp Tyr Gly Val Asn Trp Val Arg Gln Ser Pro Gly Lys Gly Leu Glu 
                165                 170                 175     


Trp Leu Gly Val Ile Trp Gly Asp Gly Ile Thr Asp Tyr Asn Ser Ala 
            180                 185                 190         


Leu Lys Ser Arg Leu Ser Val Thr Lys Asp Asn Ser Lys Ser Gln Val 
        195                 200                 205             


Phe Leu Lys Met Asn Ser Leu Gln Ser Gly Asp Ser Ala Arg Tyr Tyr 
    210                 215                 220                 


Cys Val Thr Gly Leu Phe Asp Tyr Trp Gly Gln Gly Thr Thr Leu Thr 
225                 230                 235                 240 


Val Ser Ser Glu Ser Lys Tyr Gly Pro Pro Cys Pro Pro Cys Pro Asp 
                245                 250                 255     


Phe Trp Val Leu Val Val Val Gly Gly Val Leu Ala Cys Tyr Ser Leu 
            260                 265                 270         


Leu Val Thr Val Ala Phe Ile Ile Phe Trp Val Arg Ser Lys Arg Ser 
        275                 280                 285             


Arg Leu Leu His Ser Asp Tyr Met Asn Met Thr Pro Arg Arg Pro Gly 
    290                 295                 300                 


Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro Pro Arg Asp Phe Ala 
305                 310                 315                 320 


Ala Tyr Arg Ser Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala 
                325                 330                 335     


Tyr Lys Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg 
            340                 345                 350         


Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu 
        355                 360                 365             


Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn 
    370                 375                 380                 


Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met 
385                 390                 395                 400 


Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly 
                405                 410                 415     


Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala 
            420                 425                 430         


Leu Pro Pro Arg 
        435     


<210>  392
<211>  462
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - CAR construct

<400>  392

Asp Ala Val Val Thr Gln Glu Ser Ala Leu Thr Ser Ser Pro Gly Glu 
1               5                   10                  15      


Thr Val Thr Leu Thr Cys Arg Ser Ser Thr Gly Ala Val Thr Thr Ser 
            20                  25                  30          


Asn Tyr Ala Ser Trp Val Gln Glu Lys Pro Asp His Leu Phe Thr Gly 
        35                  40                  45              


Leu Ile Gly Gly Thr Asn Asn Arg Ala Pro Gly Val Pro Ala Arg Phe 
    50                  55                  60                  


Ser Gly Ser Leu Ile Gly Asp Lys Ala Ala Leu Thr Ile Thr Gly Ala 
65                  70                  75                  80  


Gln Thr Glu Asp Glu Ala Ile Tyr Phe Cys Val Leu Trp Tyr Ser Asp 
                85                  90                  95      


His Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Gly Gly 
            100                 105                 110         


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Asp Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Ala Pro 
    130                 135                 140                 


Ser Gln Ser Leu Ser Ile Thr Cys Thr Val Ser Gly Phe Leu Leu Thr 
145                 150                 155                 160 


Asp Tyr Gly Val Asn Trp Val Arg Gln Ser Pro Gly Lys Gly Leu Glu 
                165                 170                 175     


Trp Leu Gly Val Ile Trp Gly Asp Gly Ile Thr Asp Tyr Asn Ser Ala 
            180                 185                 190         


Leu Lys Ser Arg Leu Ser Val Thr Lys Asp Asn Ser Lys Ser Gln Val 
        195                 200                 205             


Phe Leu Lys Met Asn Ser Leu Gln Ser Gly Asp Ser Ala Arg Tyr Tyr 
    210                 215                 220                 


Cys Val Thr Gly Leu Phe Asp Tyr Trp Gly Gln Gly Thr Thr Leu Thr 
225                 230                 235                 240 


Val Ser Ser Ile Glu Val Met Tyr Pro Pro Pro Tyr Leu Asp Asn Glu 
                245                 250                 255     


Lys Ser Asn Gly Thr Ile Ile His Val Lys Gly Lys His Leu Cys Pro 
            260                 265                 270         


Ser Pro Leu Phe Pro Gly Pro Ser Lys Pro Phe Trp Val Leu Val Val 
        275                 280                 285             


Val Gly Gly Val Leu Ala Cys Tyr Ser Leu Leu Val Thr Val Ala Phe 
    290                 295                 300                 


Ile Ile Phe Trp Val Arg Ser Lys Arg Ser Arg Leu Leu His Ser Asp 
305                 310                 315                 320 


Tyr Met Asn Met Thr Pro Arg Arg Pro Gly Pro Thr Arg Lys His Tyr 
                325                 330                 335     


Gln Pro Tyr Ala Pro Pro Arg Asp Phe Ala Ala Tyr Arg Ser Arg Val 
            340                 345                 350         


Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Lys Gln Gly Gln Asn 
        355                 360                 365             


Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val 
    370                 375                 380                 


Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg 
385                 390                 395                 400 


Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys 
                405                 410                 415     


Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg 
            420                 425                 430         


Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys 
        435                 440                 445             


Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
    450                 455                 460         


<210>  393
<211>  478
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - CAR construct

<400>  393

Asp Ala Val Val Thr Gln Glu Ser Ala Leu Thr Ser Ser Pro Gly Glu 
1               5                   10                  15      


Thr Val Thr Leu Thr Cys Arg Ser Ser Thr Gly Ala Val Thr Thr Ser 
            20                  25                  30          


Asn Tyr Ala Ser Trp Val Gln Glu Lys Pro Asp His Leu Phe Thr Gly 
        35                  40                  45              


Leu Ile Gly Gly Thr Asn Asn Arg Ala Pro Gly Val Pro Ala Arg Phe 
    50                  55                  60                  


Ser Gly Ser Leu Ile Gly Asp Lys Ala Ala Leu Thr Ile Thr Gly Ala 
65                  70                  75                  80  


Gln Thr Glu Asp Glu Ala Ile Tyr Phe Cys Val Leu Trp Tyr Ser Asp 
                85                  90                  95      


His Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Gly Gly 
            100                 105                 110         


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Asp Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Ala Pro 
    130                 135                 140                 


Ser Gln Ser Leu Ser Ile Thr Cys Thr Val Ser Gly Phe Leu Leu Thr 
145                 150                 155                 160 


Asp Tyr Gly Val Asn Trp Val Arg Gln Ser Pro Gly Lys Gly Leu Glu 
                165                 170                 175     


Trp Leu Gly Val Ile Trp Gly Asp Gly Ile Thr Asp Tyr Asn Ser Ala 
            180                 185                 190         


Leu Lys Ser Arg Leu Ser Val Thr Lys Asp Asn Ser Lys Ser Gln Val 
        195                 200                 205             


Phe Leu Lys Met Asn Ser Leu Gln Ser Gly Asp Ser Ala Arg Tyr Tyr 
    210                 215                 220                 


Cys Val Thr Gly Leu Phe Asp Tyr Trp Gly Gln Gly Thr Thr Leu Thr 
225                 230                 235                 240 


Val Ser Ser Glu Ser Lys Tyr Gly Pro Pro Cys Pro Pro Cys Pro Asp 
                245                 250                 255     


Phe Trp Val Leu Val Val Val Gly Gly Val Leu Ala Cys Tyr Ser Leu 
            260                 265                 270         


Leu Val Thr Val Ala Phe Ile Ile Phe Trp Val Arg Ser Lys Arg Ser 
        275                 280                 285             


Arg Leu Leu His Ser Asp Tyr Met Asn Met Thr Pro Arg Arg Pro Gly 
    290                 295                 300                 


Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro Pro Arg Asp Phe Ala 
305                 310                 315                 320 


Ala Tyr Arg Ser Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys 
                325                 330                 335     


Gln Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys 
            340                 345                 350         


Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg Val 
        355                 360                 365             


Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Lys Gln Gly Gln Asn 
    370                 375                 380                 


Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val 
385                 390                 395                 400 


Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg 
                405                 410                 415     


Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys 
            420                 425                 430         


Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg 
        435                 440                 445             


Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys 
    450                 455                 460                 


Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
465                 470                 475             


<210>  394
<211>  504
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - CAR construct

<400>  394

Asp Ala Val Val Thr Gln Glu Ser Ala Leu Thr Ser Ser Pro Gly Glu 
1               5                   10                  15      


Thr Val Thr Leu Thr Cys Arg Ser Ser Thr Gly Ala Val Thr Thr Ser 
            20                  25                  30          


Asn Tyr Ala Ser Trp Val Gln Glu Lys Pro Asp His Leu Phe Thr Gly 
        35                  40                  45              


Leu Ile Gly Gly Thr Asn Asn Arg Ala Pro Gly Val Pro Ala Arg Phe 
    50                  55                  60                  


Ser Gly Ser Leu Ile Gly Asp Lys Ala Ala Leu Thr Ile Thr Gly Ala 
65                  70                  75                  80  


Gln Thr Glu Asp Glu Ala Ile Tyr Phe Cys Val Leu Trp Tyr Ser Asp 
                85                  90                  95      


His Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Gly Gly 
            100                 105                 110         


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Asp Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Ala Pro 
    130                 135                 140                 


Ser Gln Ser Leu Ser Ile Thr Cys Thr Val Ser Gly Phe Leu Leu Thr 
145                 150                 155                 160 


Asp Tyr Gly Val Asn Trp Val Arg Gln Ser Pro Gly Lys Gly Leu Glu 
                165                 170                 175     


Trp Leu Gly Val Ile Trp Gly Asp Gly Ile Thr Asp Tyr Asn Ser Ala 
            180                 185                 190         


Leu Lys Ser Arg Leu Ser Val Thr Lys Asp Asn Ser Lys Ser Gln Val 
        195                 200                 205             


Phe Leu Lys Met Asn Ser Leu Gln Ser Gly Asp Ser Ala Arg Tyr Tyr 
    210                 215                 220                 


Cys Val Thr Gly Leu Phe Asp Tyr Trp Gly Gln Gly Thr Thr Leu Thr 
225                 230                 235                 240 


Val Ser Ser Ile Glu Val Met Tyr Pro Pro Pro Tyr Leu Asp Asn Glu 
                245                 250                 255     


Lys Ser Asn Gly Thr Ile Ile His Val Lys Gly Lys His Leu Cys Pro 
            260                 265                 270         


Ser Pro Leu Phe Pro Gly Pro Ser Lys Pro Phe Trp Val Leu Val Val 
        275                 280                 285             


Val Gly Gly Val Leu Ala Cys Tyr Ser Leu Leu Val Thr Val Ala Phe 
    290                 295                 300                 


Ile Ile Phe Trp Val Arg Ser Lys Arg Ser Arg Leu Leu His Ser Asp 
305                 310                 315                 320 


Tyr Met Asn Met Thr Pro Arg Arg Pro Gly Pro Thr Arg Lys His Tyr 
                325                 330                 335     


Gln Pro Tyr Ala Pro Pro Arg Asp Phe Ala Ala Tyr Arg Ser Lys Arg 
            340                 345                 350         


Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro 
        355                 360                 365             


Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu 
    370                 375                 380                 


Glu Glu Glu Gly Gly Cys Glu Leu Arg Val Lys Phe Ser Arg Ser Ala 
385                 390                 395                 400 


Asp Ala Pro Ala Tyr Lys Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu 
                405                 410                 415     


Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly 
            420                 425                 430         


Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu 
        435                 440                 445             


Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser 
    450                 455                 460                 


Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly 
465                 470                 475                 480 


Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu 
                485                 490                 495     


His Met Gln Ala Leu Pro Pro Arg 
            500                 


<210>  395
<211>  467
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - CAR construct

<400>  395

Asp Ile Gln Met Thr Gln Thr Thr Ser Ser Leu Ser Ala Ser Leu Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Ser Cys Arg Ala Ser Gln Asp Ile Ser Lys Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Asp Gly Thr Val Lys Leu Leu Ile 
        35                  40                  45              


Tyr His Thr Ser Arg Leu His Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Tyr Ser Leu Thr Ile Ser Asn Leu Glu Gln 
65                  70                  75                  80  


Glu Asp Ile Ala Thr Tyr Phe Cys Gln Gln Gly Asn Thr Leu Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Thr Gly Gly Gly Gly Ser 
            100                 105                 110         


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Lys Leu Gln Glu 
        115                 120                 125             


Ser Gly Pro Gly Leu Val Ala Pro Ser Gln Ser Leu Ser Val Thr Cys 
    130                 135                 140                 


Thr Val Ser Gly Val Ser Leu Pro Asp Tyr Gly Val Ser Trp Ile Arg 
145                 150                 155                 160 


Gln Pro Pro Arg Lys Gly Leu Glu Trp Leu Gly Val Ile Trp Gly Ser 
                165                 170                 175     


Glu Thr Thr Tyr Tyr Asn Ser Ala Leu Lys Ser Arg Leu Thr Ile Ile 
            180                 185                 190         


Lys Asp Asn Ser Lys Ser Gln Val Phe Leu Lys Met Asn Ser Leu Gln 
        195                 200                 205             


Thr Asp Asp Thr Ala Ile Tyr Tyr Cys Ala Lys His Tyr Tyr Tyr Gly 
    210                 215                 220                 


Gly Ser Tyr Ala Met Asp Tyr Trp Gly Gln Gly Thr Ser Val Thr Val 
225                 230                 235                 240 


Ser Ser Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr 
                245                 250                 255     


Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala 
            260                 265                 270         


Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp Phe 
        275                 280                 285             


Trp Val Leu Val Val Val Gly Gly Val Leu Ala Cys Tyr Ser Leu Leu 
    290                 295                 300                 


Val Thr Val Ala Phe Ile Ile Phe Trp Val Arg Ser Lys Arg Ser Arg 
305                 310                 315                 320 


Leu Leu His Ser Asp Tyr Met Asn Met Thr Pro Arg Arg Pro Gly Pro 
                325                 330                 335     


Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro Pro Arg Asp Phe Ala Ala 
            340                 345                 350         


Tyr Arg Ser Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr 
        355                 360                 365             


Lys Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg 
    370                 375                 380                 


Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met 
385                 390                 395                 400 


Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu 
                405                 410                 415     


Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys 
            420                 425                 430         


Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu 
        435                 440                 445             


Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu 
    450                 455                 460                 


Pro Pro Arg 
465         


<210>  396
<211>  509
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - CAR construct

<400>  396

Asp Ile Gln Met Thr Gln Thr Thr Ser Ser Leu Ser Ala Ser Leu Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Ser Cys Arg Ala Ser Gln Asp Ile Ser Lys Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Asp Gly Thr Val Lys Leu Leu Ile 
        35                  40                  45              


Tyr His Thr Ser Arg Leu His Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Tyr Ser Leu Thr Ile Ser Asn Leu Glu Gln 
65                  70                  75                  80  


Glu Asp Ile Ala Thr Tyr Phe Cys Gln Gln Gly Asn Thr Leu Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Thr Gly Gly Gly Gly Ser 
            100                 105                 110         


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Lys Leu Gln Glu 
        115                 120                 125             


Ser Gly Pro Gly Leu Val Ala Pro Ser Gln Ser Leu Ser Val Thr Cys 
    130                 135                 140                 


Thr Val Ser Gly Val Ser Leu Pro Asp Tyr Gly Val Ser Trp Ile Arg 
145                 150                 155                 160 


Gln Pro Pro Arg Lys Gly Leu Glu Trp Leu Gly Val Ile Trp Gly Ser 
                165                 170                 175     


Glu Thr Thr Tyr Tyr Asn Ser Ala Leu Lys Ser Arg Leu Thr Ile Ile 
            180                 185                 190         


Lys Asp Asn Ser Lys Ser Gln Val Phe Leu Lys Met Asn Ser Leu Gln 
        195                 200                 205             


Thr Asp Asp Thr Ala Ile Tyr Tyr Cys Ala Lys His Tyr Tyr Tyr Gly 
    210                 215                 220                 


Gly Ser Tyr Ala Met Asp Tyr Trp Gly Gln Gly Thr Ser Val Thr Val 
225                 230                 235                 240 


Ser Ser Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr 
                245                 250                 255     


Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala 
            260                 265                 270         


Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp Phe 
        275                 280                 285             


Trp Val Leu Val Val Val Gly Gly Val Leu Ala Cys Tyr Ser Leu Leu 
    290                 295                 300                 


Val Thr Val Ala Phe Ile Ile Phe Trp Val Arg Ser Lys Arg Ser Arg 
305                 310                 315                 320 


Leu Leu His Ser Asp Tyr Met Asn Met Thr Pro Arg Arg Pro Gly Pro 
                325                 330                 335     


Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro Pro Arg Asp Phe Ala Ala 
            340                 345                 350         


Tyr Arg Ser Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln 
        355                 360                 365             


Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser 
    370                 375                 380                 


Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg Val Lys 
385                 390                 395                 400 


Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Lys Gln Gly Gln Asn Gln 
                405                 410                 415     


Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu 
            420                 425                 430         


Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg 
        435                 440                 445             


Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met 
    450                 455                 460                 


Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly 
465                 470                 475                 480 


Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp 
                485                 490                 495     


Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
            500                 505                 


<210>  397
<211>  465
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - CAR construct

<400>  397

Asp Ile Gln Met Thr Gln Thr Thr Ser Ser Leu Ser Ala Ser Leu Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Ser Cys Arg Ala Ser Gln Asp Ile Ser Lys Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Asp Gly Thr Val Lys Leu Leu Ile 
        35                  40                  45              


Tyr His Thr Ser Arg Leu His Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Tyr Ser Leu Thr Ile Ser Asn Leu Glu Gln 
65                  70                  75                  80  


Glu Asp Ile Ala Thr Tyr Phe Cys Gln Gln Gly Asn Thr Leu Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Thr Gly Gly Gly Gly Ser 
            100                 105                 110         


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Lys Leu Gln Glu 
        115                 120                 125             


Ser Gly Pro Gly Leu Val Ala Pro Ser Gln Ser Leu Ser Val Thr Cys 
    130                 135                 140                 


Thr Val Ser Gly Val Ser Leu Pro Asp Tyr Gly Val Ser Trp Ile Arg 
145                 150                 155                 160 


Gln Pro Pro Arg Lys Gly Leu Glu Trp Leu Gly Val Ile Trp Gly Ser 
                165                 170                 175     


Glu Thr Thr Tyr Tyr Asn Ser Ala Leu Lys Ser Arg Leu Thr Ile Ile 
            180                 185                 190         


Lys Asp Asn Ser Lys Ser Gln Val Phe Leu Lys Met Asn Ser Leu Gln 
        195                 200                 205             


Thr Asp Asp Thr Ala Ile Tyr Tyr Cys Ala Lys His Tyr Tyr Tyr Gly 
    210                 215                 220                 


Gly Ser Tyr Ala Met Asp Tyr Trp Gly Gln Gly Thr Ser Val Thr Val 
225                 230                 235                 240 


Ser Ser Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr 
                245                 250                 255     


Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala 
            260                 265                 270         


Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile 
        275                 280                 285             


Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser 
    290                 295                 300                 


Leu Val Ile Thr Leu Tyr Cys Lys Arg Gly Arg Lys Lys Leu Leu Tyr 
305                 310                 315                 320 


Ile Phe Lys Gln Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu 
                325                 330                 335     


Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu 
            340                 345                 350         


Leu Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Lys Gln 
        355                 360                 365             


Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu 
    370                 375                 380                 


Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly 
385                 390                 395                 400 


Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln 
                405                 410                 415     


Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu 
            420                 425                 430         


Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr 
        435                 440                 445             


Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro 
    450                 455                 460                 


Arg 
465 


<210>  398
<211>  24
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - CAR construct fragment

<400>  398

Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu 
1               5                   10                  15      


Ser Leu Val Ile Thr Leu Tyr Cys 
            20                  


<210>  399
<211>  478
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - CAR construct

<400>  399

Asp Ala Val Val Thr Gln Glu Ser Ala Leu Thr Ser Ser Pro Gly Glu 
1               5                   10                  15      


Thr Val Thr Leu Thr Cys Arg Ser Ser Thr Gly Ala Val Thr Thr Ser 
            20                  25                  30          


Asn Tyr Ala Ser Trp Val Gln Glu Lys Pro Asp His Leu Phe Thr Gly 
        35                  40                  45              


Leu Ile Gly Gly Thr Asn Asn Arg Ala Pro Gly Val Pro Ala Arg Phe 
    50                  55                  60                  


Ser Gly Ser Leu Ile Gly Asp Lys Ala Ala Leu Thr Ile Thr Gly Ala 
65                  70                  75                  80  


Gln Thr Glu Asp Glu Ala Ile Tyr Phe Cys Val Leu Trp Tyr Ser Asp 
                85                  90                  95      


His Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Gly Gly 
            100                 105                 110         


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Asp Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Ala Pro 
    130                 135                 140                 


Ser Gln Ser Leu Ser Ile Thr Cys Thr Val Ser Gly Phe Leu Leu Thr 
145                 150                 155                 160 


Asp Tyr Gly Val Asn Trp Val Arg Gln Ser Pro Gly Lys Gly Leu Glu 
                165                 170                 175     


Trp Leu Gly Val Ile Trp Gly Asp Gly Ile Thr Asp Tyr Asn Ser Ala 
            180                 185                 190         


Leu Lys Ser Arg Leu Ser Val Thr Lys Asp Asn Ser Lys Ser Gln Val 
        195                 200                 205             


Phe Leu Lys Met Asn Ser Leu Gln Ser Gly Asp Ser Ala Arg Tyr Tyr 
    210                 215                 220                 


Cys Val Thr Gly Leu Phe Asp Tyr Trp Gly Gln Gly Thr Thr Leu Thr 
225                 230                 235                 240 


Val Ser Ser Glu Ser Lys Tyr Gly Pro Pro Cys Pro Pro Cys Pro Asp 
                245                 250                 255     


Phe Trp Val Leu Val Val Val Gly Gly Val Leu Ala Cys Tyr Ser Leu 
            260                 265                 270         


Leu Val Thr Val Ala Phe Ile Ile Phe Trp Val Arg Ser Lys Arg Ser 
        275                 280                 285             


Arg Leu Leu His Ser Asp Tyr Met Asn Met Thr Pro Arg Arg Pro Gly 
    290                 295                 300                 


Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro Pro Arg Asp Phe Ala 
305                 310                 315                 320 


Ala Tyr Arg Ser Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys 
                325                 330                 335     


Gln Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys 
            340                 345                 350         


Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg Val 
        355                 360                 365             


Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Lys Gln Gly Gln Asn 
    370                 375                 380                 


Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val 
385                 390                 395                 400 


Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg 
                405                 410                 415     


Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys 
            420                 425                 430         


Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg 
        435                 440                 445             


Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys 
    450                 455                 460                 


Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
465                 470                 475             


<210>  400
<211>  1434
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Made in Lab - CAR construct

<400>  400
gacgccgttg tgacccagga atccgctctg acctcttctc caggcgaaac cgtgactctg       60

acttgccgta gtagcaccgg ggctgtgacc acatctaact atgccagttg ggtccaggaa      120

aaaccggatc acctgtttac tggcctgatt ggcggcacca acaatcgcgc accgggtgtg      180

cccgctcgtt tcagcggttc cctgattggg gacaaggcag cactgactat caccggcgcc      240

cagaccgaag atgaggcgat ctatttttgc gtcctgtggt acagcgacca ttgggtgttc      300

gggggaggca ccaaactgac agtgctgggc ggaggaggag gttcaggagg aggaggtagc      360

gggggaggcg gttccggggg aggcggttct gatgtgcagc tgcaagaatc cgggccagga      420

ctggttgcgc cttctcagag tctgtcaatt acatgtactg ttagtggctt tctgctgacc      480

gactatggtg tgaactgggt tcgtcagagc ccaggcaagg gtctggagtg gctgggagtg      540

atttgggggg atggaatcac agactacaat agcgcactga aatctcggct gagtgttacc      600

aaagataaca gcaagtccca ggtcttcctg aagatgaaca gcctgcaaag cggcgactcc      660

gctcgctatt actgcgttac cggactgttt gattattggg ggcaggggac aactctgact      720

gtttcctccg aaagcaagta tggcccacct tgtccacctt gtcccgattt ttgggttctg      780

gtagttgtgg gaggtgttct cgcctgttat agtctcctcg ttactgtagc gttcatcatt      840

ttttgggtaa ggagtaagag gagcaggctc ctgcacagtg actacatgaa catgactccc      900

cgccgccccg ggcccacccg caagcattac cagccctatg ccccaccacg cgacttcgca      960

gcctatcgct ccaaacgggg cagaaagaaa ctcctgtata tattcaaaca accatttatg     1020

agaccagtac aaactactca agaggaagat ggctgtagct gccgatttcc agaagaagaa     1080

gaaggaggat gtgaactgag agtgaagttc agcaggagcg cagacgcccc cgcgtacaag     1140

cagggccaga accagctcta taacgagctc aatctaggac gaagagagga gtacgatgtt     1200

ttggacaaga gacgtggccg ggaccctgag atggggggaa agccgagaag gaagaaccct     1260

caggaaggcc tgtacaatga actgcagaaa gataagatgg cggaggccta cagtgagatt     1320

gggatgaaag gcgagcgccg gaggggcaag gggcacgatg gcctttacca gggtctcagt     1380

acagccacca aggacaccta cgacgccctt cacatgcagg ccctgccccc tcgc           1434


<210>  401
<211>  478
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - CAR construct

<400>  401

Gln Ala Val Val Thr Gln Glu Pro Ser Leu Thr Val Ser Pro Gly Gly 
1               5                   10                  15      


Thr Val Thr Leu Thr Cys Gly Ser Ser Thr Gly Ala Val Thr Thr Ser 
            20                  25                  30          


Asn Tyr Ala Ser Trp Val Gln Gln Lys Pro Gly Gln Ala Pro Arg Gly 
        35                  40                  45              


Leu Ile Gly Gly Thr Asn Asn Arg Ala Pro Gly Val Pro Ala Arg Phe 
    50                  55                  60                  


Ser Gly Ser Leu Leu Gly Gly Lys Ala Ala Leu Thr Ile Ser Gly Ala 
65                  70                  75                  80  


Gln Pro Glu Asp Glu Ala Glu Tyr Tyr Cys Val Leu Trp Tyr Ser Asp 
                85                  90                  95      


His Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Gly Gly 
            100                 105                 110         


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro 
    130                 135                 140                 


Ser Glu Thr Leu Ser Ile Thr Cys Thr Val Ser Gly Phe Leu Leu Thr 
145                 150                 155                 160 


Asp Tyr Gly Val Asn Trp Val Arg Gln Pro Pro Gly Lys Gly Leu Glu 
                165                 170                 175     


Trp Leu Gly Val Ile Trp Gly Asp Gly Ile Thr Asp Tyr Asn Pro Ser 
            180                 185                 190         


Leu Lys Ser Arg Leu Thr Val Ser Lys Asp Thr Ser Lys Asn Gln Val 
        195                 200                 205             


Ser Leu Lys Met Ser Ser Leu Thr Ala Ala Asp Thr Ala Val Tyr Tyr 
    210                 215                 220                 


Cys Val Thr Gly Leu Phe Asp Tyr Trp Gly Gln Gly Thr Leu Leu Thr 
225                 230                 235                 240 


Val Ser Ser Glu Ser Lys Tyr Gly Pro Pro Cys Pro Pro Cys Pro Asp 
                245                 250                 255     


Phe Trp Val Leu Val Val Val Gly Gly Val Leu Ala Cys Tyr Ser Leu 
            260                 265                 270         


Leu Val Thr Val Ala Phe Ile Ile Phe Trp Val Arg Ser Lys Arg Ser 
        275                 280                 285             


Arg Leu Leu His Ser Asp Tyr Met Asn Met Thr Pro Arg Arg Pro Gly 
    290                 295                 300                 


Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro Pro Arg Asp Phe Ala 
305                 310                 315                 320 


Ala Tyr Arg Ser Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys 
                325                 330                 335     


Gln Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys 
            340                 345                 350         


Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg Val 
        355                 360                 365             


Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Lys Gln Gly Gln Asn 
    370                 375                 380                 


Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val 
385                 390                 395                 400 


Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg 
                405                 410                 415     


Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys 
            420                 425                 430         


Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg 
        435                 440                 445             


Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys 
    450                 455                 460                 


Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
465                 470                 475             


<210>  402
<211>  1434
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Made in Lab - CAR construct

<400>  402
caggcggtag tcacccagga gccaagtctc acggtgagcc ccggcggtac cgtcacactt       60

acatgcggaa gctctaccgg ggctgtgacc acaagcaact acgcatcctg ggtccagcag      120

aaacccggtc aggcgccccg gggcctcatt ggtgggacaa ataacagagc cccgggtgtt      180

cccgcccgat tttctggcag tcttctggga ggaaaggccg ctctgacaat atctggcgca      240

cagcccgaag acgaggccga gtactattgc gtgttgtggt atagcgacca ctgggtattc      300

ggtggaggaa caaagctgac agtgctcggc ggaggaggag gttcaggagg aggaggtagc      360

gggggaggcg gttccggggg aggcggttct caagtgcaat tgcaggagag tggacctgga      420

ctcgtgaaac catctgaaac actctccata acttgtacgg tttcagggtt cctgctgaca      480

gactatggag taaactgggt taggcagcca cccggcaagg gcttggagtg gctgggcgtc      540

atttggggcg acggaatcac cgactataac ccatcactca aatctcggct taccgtctcc      600

aaggatacga gtaagaatca ggtcagcctg aaaatgtcat ccctcacagc tgcggacacc      660

gccgtgtact actgtgtgac aggacttttt gactactggg gccaggggac cctgctcaca      720

gttagctccg aaagcaagta tggcccacct tgtccacctt gtcccgattt ttgggttctg      780

gtagttgtgg gaggtgttct cgcctgttat agtctcctcg ttactgtagc gttcatcatt      840

ttttgggtaa ggagtaagag gagcaggctc ctgcacagtg actacatgaa catgactcca      900

cgccgcccag gtcctacacg caagcattac cagccctatg ccccaccacg cgacttcgca      960

gcctatcgct ccaaacgggg cagaaagaaa ctcctgtata tattcaaaca accatttatg     1020

agaccagtac aaactactca agaggaagat ggctgtagct gccgatttcc agaagaagaa     1080

gaaggaggat gtgaactgag agtgaagttc agcaggagcg cagacgcccc cgcgtacaag     1140

cagggccaga accagctcta taacgagctc aatctaggac gaagagagga gtacgatgtt     1200

ttggacaaga gacgtggccg ggaccctgag atggggggaa agccgagaag gaagaaccct     1260

caggaaggcc tgtacaatga actgcagaaa gataagatgg cggaggccta cagtgagatt     1320

gggatgaaag gcgagcgccg gaggggcaag gggcacgatg gcctttacca gggtctcagt     1380

acagccacca aggacaccta cgacgccctt cacatgcagg ccctgccccc tcgc           1434


<210>  403
<211>  478
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - CAR construct

<400>  403

Gln Ala Val Val Thr Gln Glu Pro Ser Leu Thr Val Ser Pro Gly Gly 
1               5                   10                  15      


Thr Val Thr Leu Thr Cys Gly Ser Ser Thr Gly Ala Val Thr Thr Ser 
            20                  25                  30          


Asn Tyr Ala Ser Trp Val Gln Glu Lys Pro Asp His Leu Phe Arg Gly 
        35                  40                  45              


Leu Ile Gly Gly Thr Asn Asn Arg Ala Pro Gly Val Pro Ala Arg Phe 
    50                  55                  60                  


Ser Gly Ser Leu Leu Gly Gly Lys Ala Ala Leu Thr Ile Ser Gly Ala 
65                  70                  75                  80  


Gln Pro Glu Asp Glu Ala Ile Tyr Phe Cys Val Leu Trp Tyr Ser Asp 
                85                  90                  95      


His Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Gly Gly 
            100                 105                 110         


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro 
    130                 135                 140                 


Ser Glu Thr Leu Ser Ile Thr Cys Thr Val Ser Gly Phe Leu Leu Thr 
145                 150                 155                 160 


Asp Tyr Gly Val Asn Trp Val Arg Gln Pro Pro Gly Lys Gly Leu Glu 
                165                 170                 175     


Trp Leu Gly Val Ile Trp Gly Asp Gly Ile Thr Asp Tyr Asn Pro Ser 
            180                 185                 190         


Leu Lys Ser Arg Leu Thr Val Ser Lys Asp Thr Ser Lys Asn Gln Val 
        195                 200                 205             


Ser Leu Lys Met Ser Ser Leu Thr Ala Ala Asp Thr Ala Arg Tyr Tyr 
    210                 215                 220                 


Cys Val Thr Gly Leu Phe Asp Tyr Trp Gly Gln Gly Thr Thr Leu Thr 
225                 230                 235                 240 


Val Ser Ser Glu Ser Lys Tyr Gly Pro Pro Cys Pro Pro Cys Pro Asp 
                245                 250                 255     


Phe Trp Val Leu Val Val Val Gly Gly Val Leu Ala Cys Tyr Ser Leu 
            260                 265                 270         


Leu Val Thr Val Ala Phe Ile Ile Phe Trp Val Arg Ser Lys Arg Ser 
        275                 280                 285             


Arg Leu Leu His Ser Asp Tyr Met Asn Met Thr Pro Arg Arg Pro Gly 
    290                 295                 300                 


Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro Pro Arg Asp Phe Ala 
305                 310                 315                 320 


Ala Tyr Arg Ser Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys 
                325                 330                 335     


Gln Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys 
            340                 345                 350         


Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg Val 
        355                 360                 365             


Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Lys Gln Gly Gln Asn 
    370                 375                 380                 


Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val 
385                 390                 395                 400 


Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg 
                405                 410                 415     


Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys 
            420                 425                 430         


Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg 
        435                 440                 445             


Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys 
    450                 455                 460                 


Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
465                 470                 475             


<210>  404
<211>  1434
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Made in Lab - CAR construct

<400>  404
caggctgtgg tgactcaaga gccctcactg actgtgtccc caggagggac agtcactctc       60

acctgtggct ccagcactgg agctgtcacc acttccaact atgcctcatg ggtgcaggag      120

aagcctgacc acctcttcag ggggctgatt ggtggcacaa acaacagggc tcctggggtg      180

cctgcccggt tctcaggctc cctccttggg ggcaaagctg ccctgaccat ttcgggtgcg      240

cagcctgagg atgaggctat ttatttctgc gtgctctggt atagtgacca ttgggtgttc      300

ggcggaggga ccaagctgac cgtcctaggc ggcggaggag gttcaggagg aggaggtagc      360

ggcggaggcg gttccggggg aggaggttct caggtgcaac tgcaggagtc gggcccagga      420

ctggtgaagc cttcggagac cctgtccatc acctgcactg tctctggttt cctgctgacc      480

gactacggcg taaactgggt gcggcagccc ccagggaagg gactggagtg gctgggggtg      540

atctggggtg acgggatcac cgactacaac ccctccctca agagtcgact gaccgtgtcc      600

aaggacacat ccaagaacca ggtgtccctg aagatgagct ctctgaccgc cgcagacacg      660

gcccggtatt actgtgtcac cggcctgttc gactactggg gccagggcac caccctgacc      720

gtctcctcag aaagcaagta tggcccgcct tgtccacctt gtcccgattt ttgggttctg      780

gtagttgtgg gaggtgttct cgcctgttat agtctcctcg ttactgtagc gttcatcatt      840

ttttgggtaa ggagtaagag gagcaggctc ctgcacagtg actacatgaa catgactcca      900

cgccgcccag gtcctacacg caagcattac cagccctatg ccccaccacg cgacttcgca      960

gcctatcgct ccaaacgggg cagaaagaaa ctcctgtata tattcaaaca accatttatg     1020

agaccagtac aaactactca agaggaagat ggctgtagct gccgatttcc agaagaagaa     1080

gaaggaggat gtgaactgag agtgaagttc agcaggagcg cagacgcccc cgcgtacaag     1140

cagggccaga accagctcta taacgagctc aatctaggac gaagagagga gtacgatgtt     1200

ttggacaaga gacgtggccg ggaccctgag atggggggaa agccgagaag gaagaaccct     1260

caggaaggcc tgtacaatga actgcagaaa gataagatgg cggaggccta cagtgagatt     1320

gggatgaaag gcgagcgccg gaggggcaag gggcacgatg gcctttacca gggtctcagt     1380

acagccacca aggacaccta cgacgccctt cacatgcagg ccctgccccc tcgc           1434


<210>  405
<211>  478
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - CAR construct

<400>  405

Gln Ala Val Val Thr Gln Glu Pro Ser Leu Thr Val Ser Pro Gly Gly 
1               5                   10                  15      


Thr Val Thr Leu Thr Cys Gly Ser Ser Thr Gly Ala Val Thr Thr Ser 
            20                  25                  30          


Asn Tyr Ala Ser Trp Val Gln Glu Lys Pro Asp His Leu Phe Arg Gly 
        35                  40                  45              


Leu Ile Gly Gly Thr Asn Asn Arg Ala Pro Gly Val Pro Ala Arg Phe 
    50                  55                  60                  


Ser Gly Ser Leu Leu Gly Gly Lys Ala Ala Leu Thr Ile Ser Gly Ala 
65                  70                  75                  80  


Gln Pro Glu Asp Glu Ala Ile Tyr Phe Cys Val Leu Trp Tyr Ser Asp 
                85                  90                  95      


His Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Gly Gly 
            100                 105                 110         


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro 
    130                 135                 140                 


Ser Glu Thr Leu Ser Ile Thr Cys Thr Val Ser Gly Phe Leu Leu Thr 
145                 150                 155                 160 


Asp Tyr Gly Val Asn Trp Val Arg Gln Pro Pro Gly Lys Gly Leu Glu 
                165                 170                 175     


Trp Leu Gly Val Ile Trp Gly Asp Gly Ile Thr Asp Tyr Asn Pro Ser 
            180                 185                 190         


Leu Lys Ser Arg Leu Thr Val Ser Lys Asp Thr Ser Lys Asn Gln Val 
        195                 200                 205             


Ser Leu Lys Met Ser Ser Leu Thr Asp Ala Asp Thr Ala Arg Tyr Tyr 
    210                 215                 220                 


Cys Val Thr Gly Leu Phe Asp Tyr Trp Gly Gln Gly Thr Thr Leu Thr 
225                 230                 235                 240 


Val Ser Ser Glu Ser Lys Tyr Gly Pro Pro Cys Pro Pro Cys Pro Asp 
                245                 250                 255     


Phe Trp Val Leu Val Val Val Gly Gly Val Leu Ala Cys Tyr Ser Leu 
            260                 265                 270         


Leu Val Thr Val Ala Phe Ile Ile Phe Trp Val Arg Ser Lys Arg Ser 
        275                 280                 285             


Arg Leu Leu His Ser Asp Tyr Met Asn Met Thr Pro Arg Arg Pro Gly 
    290                 295                 300                 


Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro Pro Arg Asp Phe Ala 
305                 310                 315                 320 


Ala Tyr Arg Ser Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys 
                325                 330                 335     


Gln Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys 
            340                 345                 350         


Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg Val 
        355                 360                 365             


Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Lys Gln Gly Gln Asn 
    370                 375                 380                 


Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val 
385                 390                 395                 400 


Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg 
                405                 410                 415     


Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys 
            420                 425                 430         


Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg 
        435                 440                 445             


Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys 
    450                 455                 460                 


Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
465                 470                 475             


<210>  406
<211>  1434
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Made in Lab - CAR construct

<400>  406
caggctgtgg tgactcagga gccctcactg actgtgtccc caggagggac agtcactctc       60

acctgtggct ccagcactgg agctgtcacc acttccaact atgcctcatg ggtgcaggag      120

aagcctgacc acctcttcag ggggctgatt ggtggcacaa acaacagggc tcctggggtg      180

cctgcccggt tctcaggctc cctccttggg ggcaaagctg ccctgaccat ttcgggtgcg      240

cagcctgagg atgaggctat ttatttctgc gtgctctggt atagtgacca ttgggtgttc      300

ggcggaggga ccaagctgac cgtcctaggc ggtggaggag gtagcggcgg tgggggatct      360

ggaggcgggg gttcaggtgg tggtgggtct caggtgcagc tgcaggagtc gggcccagga      420

ctggtgaagc cttcggagac cctgtccatc acctgcactg tctctggttt cctgctgacc      480

gactacggcg taaactgggt gcggcagccc ccagggaagg gactggagtg gctgggggtg      540

atctggggtg acgggatcac cgactacaac ccctccctca agagtcgact gaccgtgtcc      600

aaggacacat ccaagaacca ggtgtccctg aagatgagct ctctgaccga cgcagacacg      660

gcccggtatt actgtgtcac cggcctgttc gactactggg gccagggcac caccctgacc      720

gtctcctcag aaagcaagta tggcccacct tgtccacctt gtcccgattt ttgggttctg      780

gtagttgtgg gaggtgttct cgcctgttat agtctcctcg ttactgtagc gttcatcatt      840

ttttgggtaa ggagtaagag gagcaggctc ctgcacagtg actacatgaa catgactcca      900

cgccgcccag gtcctacacg caagcattac cagccctatg ccccaccacg cgacttcgca      960

gcctatcgct ccaaacgggg cagaaagaaa ctcctgtata tattcaaaca accatttatg     1020

agaccagtac aaactactca agaggaagat ggctgtagct gccgatttcc agaagaagaa     1080

gaaggaggat gtgaactgag agtgaagttc agcaggagcg cagacgcccc cgcgtacaag     1140

cagggccaga accagctcta taacgagctc aatctaggac gaagagagga gtacgatgtt     1200

ttggacaaga gacgtggccg ggaccctgag atggggggaa agccgagaag gaagaaccct     1260

caggaaggcc tgtacaatga actgcagaaa gataagatgg cggaggccta cagtgagatt     1320

gggatgaaag gcgagcgccg gaggggcaag gggcacgatg gcctttacca gggtctcagt     1380

acagccacca aggacaccta cgacgccctt cacatgcagg ccctgccccc tcgc           1434


<210>  407
<211>  478
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - CAR construct

<400>  407

Gln Ala Val Val Thr Gln Glu Pro Ser Leu Thr Val Ser Pro Gly Gly 
1               5                   10                  15      


Thr Val Thr Leu Thr Cys Gly Ser Ser Thr Gly Ala Val Thr Thr Ser 
            20                  25                  30          


Asn Tyr Ala Ser Trp Val Gln Glu Lys Pro Asp His Leu Phe Arg Gly 
        35                  40                  45              


Leu Ile Gly Gly Thr Asn Asn Arg Ala Pro Gly Val Pro Ala Arg Phe 
    50                  55                  60                  


Ser Gly Ser Leu Leu Gly Gly Lys Ala Ala Leu Thr Ile Ser Gly Ala 
65                  70                  75                  80  


Gln Pro Glu Asp Glu Ala Ile Tyr Phe Cys Val Leu Trp Tyr Ser Asp 
                85                  90                  95      


His Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Gly Gly 
            100                 105                 110         


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Gln Val Gln Leu Gln Gln Ser Gly Pro Gly Leu Val Lys Pro 
    130                 135                 140                 


Ser Glu Thr Leu Ser Ile Thr Cys Thr Val Ser Gly Phe Leu Leu Thr 
145                 150                 155                 160 


Asp Tyr Gly Val Asn Trp Val Arg Gln Pro Pro Gly Lys Gly Leu Glu 
                165                 170                 175     


Trp Leu Gly Val Ile Trp Gly Asp Gly Ile Thr Asp Tyr Asn Pro Ser 
            180                 185                 190         


Leu Lys Ser Arg Leu Thr Val Ser Lys Asp Thr Ser Lys Asn Gln Val 
        195                 200                 205             


Ser Leu Lys Met Ser Ser Leu Thr Asp Ala Asp Thr Ala Arg Tyr Tyr 
    210                 215                 220                 


Cys Val Thr Gly Leu Phe Asp Tyr Trp Gly Gln Gly Thr Thr Leu Thr 
225                 230                 235                 240 


Val Ser Ser Glu Ser Lys Tyr Gly Pro Pro Cys Pro Pro Cys Pro Asp 
                245                 250                 255     


Phe Trp Val Leu Val Val Val Gly Gly Val Leu Ala Cys Tyr Ser Leu 
            260                 265                 270         


Leu Val Thr Val Ala Phe Ile Ile Phe Trp Val Arg Ser Lys Arg Ser 
        275                 280                 285             


Arg Leu Leu His Ser Asp Tyr Met Asn Met Thr Pro Arg Arg Pro Gly 
    290                 295                 300                 


Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro Pro Arg Asp Phe Ala 
305                 310                 315                 320 


Ala Tyr Arg Ser Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys 
                325                 330                 335     


Gln Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys 
            340                 345                 350         


Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg Val 
        355                 360                 365             


Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Lys Gln Gly Gln Asn 
    370                 375                 380                 


Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val 
385                 390                 395                 400 


Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg 
                405                 410                 415     


Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys 
            420                 425                 430         


Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg 
        435                 440                 445             


Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys 
    450                 455                 460                 


Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
465                 470                 475             


<210>  408
<211>  1434
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Made in Lab - CAR construct

<400>  408
caggctgtgg tgactcagga gccctcactg actgtgtccc caggagggac agtcactctc       60

acctgtggct ccagcactgg agctgtcacc acttccaact atgcctcatg ggtgcaggag      120

aagcctgacc acctcttcag ggggctgatt ggtggcacaa acaacagggc tcctggggtg      180

cctgcccggt tctcaggctc cctccttggg ggcaaagctg ccctgaccat ttcgggtgcg      240

cagcctgagg atgaggctat ttatttctgc gtgctctggt atagtgacca ttgggtgttc      300

ggcggaggga ccaagctgac cgtcctaggc ggtggaggag gtagcggcgg tgggggatct      360

ggaggcgggg gttcaggtgg tggtgggtct caggtgcagc tgcagcagtc gggcccagga      420

ctggtgaagc cttcggagac cctgtccatc acctgcactg tctctggttt cctgctgacc      480

gactacggcg taaactgggt gcggcagccc ccagggaagg gactggagtg gctgggggtg      540

atctggggtg acgggatcac cgactacaac ccctccctca agagtcgact gaccgtgtcc      600

aaggacacat ccaagaacca ggtgtccctg aagatgagct ctctgaccga cgcagacacg      660

gcccggtatt actgtgtcac cggcctgttc gactactggg gccagggcac caccctgacc      720

gtctcctcag aaagcaagta tggcccacct tgtccacctt gtcccgattt ttgggttctg      780

gtagttgtgg gaggtgttct cgcctgttat agtctcctcg ttactgtagc gttcatcatt      840

ttttgggtaa ggagtaagag gagcaggctc ctgcacagtg actacatgaa catgactcca      900

cgccgcccag gtcctacacg caagcattac cagccctatg ccccaccacg cgacttcgca      960

gcctatcgct ccaaacgggg cagaaagaaa ctcctgtata tattcaaaca accatttatg     1020

agaccagtac aaactactca agaggaagat ggctgtagct gccgatttcc agaagaagaa     1080

gaaggaggat gtgaactgag agtgaagttc agcaggagcg cagacgcccc cgcgtacaag     1140

cagggccaga accagctcta taacgagctc aatctaggac gaagagagga gtacgatgtt     1200

ttggacaaga gacgtggccg ggaccctgag atggggggaa agccgagaag gaagaaccct     1260

caggaaggcc tgtacaatga actgcagaaa gataagatgg cggaggccta cagtgagatt     1320

gggatgaaag gcgagcgccg gaggggcaag gggcacgatg gcctttacca gggtctcagt     1380

acagccacca aggacaccta cgacgccctt cacatgcagg ccctgccccc tcgc           1434


<210>  409
<211>  478
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - CAR construct

<400>  409

Gln Ala Val Val Thr Gln Glu Pro Ser Leu Thr Val Ser Pro Gly Gly 
1               5                   10                  15      


Thr Val Thr Leu Thr Cys Gly Ser Ser Thr Gly Ala Val Thr Thr Ser 
            20                  25                  30          


Asn Tyr Ala Ser Trp Val Gln Glu Lys Pro Asp His Leu Phe Arg Gly 
        35                  40                  45              


Leu Ile Gly Gly Thr Asn Asn Arg Ala Pro Gly Val Pro Ala Arg Phe 
    50                  55                  60                  


Ser Gly Ser Leu Leu Gly Gly Lys Ala Ala Leu Thr Ile Ser Gly Ala 
65                  70                  75                  80  


Gln Pro Glu Asp Glu Ala Ile Tyr Phe Cys Val Leu Trp Tyr Ser Asp 
                85                  90                  95      


His Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Asp Gly Gly Gly 
            100                 105                 110         


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro 
    130                 135                 140                 


Ser Glu Thr Leu Ser Ile Thr Cys Thr Val Ser Gly Phe Leu Leu Thr 
145                 150                 155                 160 


Asp Tyr Gly Val Asn Trp Val Arg Gln Pro Pro Gly Lys Gly Leu Glu 
                165                 170                 175     


Trp Leu Gly Val Ile Trp Gly Asp Gly Ile Thr Asp Tyr Asn Pro Ser 
            180                 185                 190         


Leu Lys Ser Arg Leu Thr Val Ser Lys Asp Thr Ser Lys Asn Gln Val 
        195                 200                 205             


Ser Leu Lys Met Ser Ser Leu Thr Asp Ala Asp Thr Ala Arg Tyr Tyr 
    210                 215                 220                 


Cys Val Thr Gly Leu Phe Asp Tyr Trp Gly Gln Gly Thr Thr Leu Thr 
225                 230                 235                 240 


Val Ser Ser Glu Ser Lys Tyr Gly Pro Pro Cys Pro Pro Cys Pro Asp 
                245                 250                 255     


Phe Trp Val Leu Val Val Val Gly Gly Val Leu Ala Cys Tyr Ser Leu 
            260                 265                 270         


Leu Val Thr Val Ala Phe Ile Ile Phe Trp Val Arg Ser Lys Arg Ser 
        275                 280                 285             


Arg Leu Leu His Ser Asp Tyr Met Asn Met Thr Pro Arg Arg Pro Gly 
    290                 295                 300                 


Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro Pro Arg Asp Phe Ala 
305                 310                 315                 320 


Ala Tyr Arg Ser Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys 
                325                 330                 335     


Gln Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys 
            340                 345                 350         


Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg Val 
        355                 360                 365             


Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Lys Gln Gly Gln Asn 
    370                 375                 380                 


Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val 
385                 390                 395                 400 


Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg 
                405                 410                 415     


Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys 
            420                 425                 430         


Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg 
        435                 440                 445             


Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys 
    450                 455                 460                 


Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
465                 470                 475             


<210>  410
<211>  1434
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Made in Lab - CAR construct

<400>  410
caggctgtgg tgactcagga gccctcactg actgtgtccc caggagggac agtcactctc       60

acctgtggct ccagcactgg agctgtcacc acttccaact atgcctcatg ggtgcaggag      120

aagcctgacc acctcttcag ggggctgatt ggtggcacaa acaacagggc tcctggggtg      180

cctgcccggt tctcaggctc cctccttggg ggcaaagctg ccctgaccat ttcgggtgcg      240

cagcctgagg atgaggctat ttatttctgc gtgctctggt atagtgacca ttgggtgttc      300

ggcggaggga ccaagctgac cgtcgacggc ggtggaggag gtagcggcgg tgggggatct      360

ggaggcgggg gttcaggtgg tggtgggtct caggtgcagc tgcaggagtc gggcccagga      420

ctggtgaagc cttcggagac cctgtccatc acctgcactg tctctggttt cctgctgacc      480

gactacggcg taaactgggt gcggcagccc ccagggaagg gactggagtg gctgggggtg      540

atctggggtg acgggatcac cgactacaac ccctccctca agagtcgact gaccgtgtcc      600

aaggacacat ccaagaacca ggtgtccctg aagatgagct ctctgaccga cgcagacacg      660

gcccggtatt actgtgtcac cggcctgttc gactactggg gccagggcac caccctgacc      720

gtctcctcag aaagcaagta tggcccacct tgtccacctt gtcccgattt ttgggttctg      780

gtagttgtgg gaggtgttct cgcctgttat agtctcctcg ttactgtagc gttcatcatt      840

ttttgggtaa ggagtaagag gagcaggctc ctgcacagtg actacatgaa catgactcca      900

cgccgcccag gtcctacacg caagcattac cagccctatg ccccaccacg cgacttcgca      960

gcctatcgct ccaaacgggg cagaaagaaa ctcctgtata tattcaaaca accatttatg     1020

agaccagtac aaactactca agaggaagat ggctgtagct gccgatttcc agaagaagaa     1080

gaaggaggat gtgaactgag agtgaagttc agcaggagcg cagacgcccc cgcgtacaag     1140

cagggccaga accagctcta taacgagctc aatctaggac gaagagagga gtacgatgtt     1200

ttggacaaga gacgtggccg ggaccctgag atggggggaa agccgagaag gaagaaccct     1260

caggaaggcc tgtacaatga actgcagaaa gataagatgg cggaggccta cagtgagatt     1320

gggatgaaag gcgagcgccg gaggggcaag gggcacgatg gcctttacca gggtctcagt     1380

acagccacca aggacaccta cgacgccctt cacatgcagg ccctgccccc tcgc           1434


<210>  411
<211>  478
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - CAR construct

<400>  411

Gln Ala Val Val Thr Gln Glu Pro Ser Leu Thr Val Ser Pro Gly Gly 
1               5                   10                  15      


Thr Val Thr Leu Thr Cys Gly Ser Ser Thr Gly Ala Val Thr Thr Ser 
            20                  25                  30          


Asn Tyr Ala Ser Trp Val Gln Glu Lys Pro Asp His Leu Phe Arg Gly 
        35                  40                  45              


Leu Ile Gly Gly Thr Asn Asn Arg Ala Pro Gly Val Pro Ala Arg Phe 
    50                  55                  60                  


Ser Gly Ser Leu Leu Gly Gly Lys Ala Ala Leu Thr Ile Ser Gly Ala 
65                  70                  75                  80  


Gln Pro Glu Asp Glu Ala Ile Tyr Phe Cys Val Leu Trp Tyr Ser Asp 
                85                  90                  95      


His Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Asp Gly Gly Gly 
            100                 105                 110         


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Gln Val Gln Leu Gln Gln Ser Gly Pro Gly Leu Val Lys Pro 
    130                 135                 140                 


Ser Glu Thr Leu Ser Ile Thr Cys Thr Val Ser Gly Phe Leu Leu Thr 
145                 150                 155                 160 


Asp Tyr Gly Val Asn Trp Val Arg Gln Pro Pro Gly Lys Gly Leu Glu 
                165                 170                 175     


Trp Leu Gly Val Ile Trp Gly Asp Gly Ile Thr Asp Tyr Asn Pro Ser 
            180                 185                 190         


Leu Lys Ser Arg Leu Thr Val Ser Lys Asp Thr Ser Lys Asn Gln Val 
        195                 200                 205             


Ser Leu Lys Met Ser Ser Leu Thr Asp Ala Asp Thr Ala Arg Tyr Tyr 
    210                 215                 220                 


Cys Val Thr Gly Leu Phe Asp Tyr Trp Gly Gln Gly Thr Thr Leu Thr 
225                 230                 235                 240 


Val Ser Ser Glu Ser Lys Tyr Gly Pro Pro Cys Pro Pro Cys Pro Asp 
                245                 250                 255     


Phe Trp Val Leu Val Val Val Gly Gly Val Leu Ala Cys Tyr Ser Leu 
            260                 265                 270         


Leu Val Thr Val Ala Phe Ile Ile Phe Trp Val Arg Ser Lys Arg Ser 
        275                 280                 285             


Arg Leu Leu His Ser Asp Tyr Met Asn Met Thr Pro Arg Arg Pro Gly 
    290                 295                 300                 


Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro Pro Arg Asp Phe Ala 
305                 310                 315                 320 


Ala Tyr Arg Ser Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys 
                325                 330                 335     


Gln Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys 
            340                 345                 350         


Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg Val 
        355                 360                 365             


Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Lys Gln Gly Gln Asn 
    370                 375                 380                 


Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val 
385                 390                 395                 400 


Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg 
                405                 410                 415     


Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys 
            420                 425                 430         


Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg 
        435                 440                 445             


Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys 
    450                 455                 460                 


Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
465                 470                 475             


<210>  412
<211>  1434
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Made in Lab - CAR construct

<400>  412
caggctgtgg tgactcagga gccctcactg actgtgtccc caggagggac agtcactctc       60

acctgtggct ccagcactgg agctgtcacc acttccaact atgcctcatg ggtgcaggag      120

aagcctgacc acctcttcag ggggctgatt ggtggcacaa acaacagggc tcctggggtg      180

cctgcccggt tctcaggctc cctccttggg ggcaaagctg ccctgaccat ttcgggtgcg      240

cagcctgagg atgaggctat ttatttctgc gtgctctggt atagtgacca ttgggtgttc      300

ggcggaggga ccaagctgac cgtcgacggc ggaggaggag gttcaggagg cggaggtagc      360

gggggaggcg gttccggggg aggcggttct caggtgcagc tgcagcagtc gggcccagga      420

ctggtgaagc cttcggagac cctgtccatc acctgcactg tctctggttt cctgctgacc      480

gactacggcg taaactgggt gcggcagccc ccagggaagg gactggagtg gctgggggtg      540

atctggggtg acgggatcac cgactacaac ccctccctca agagtcgact gaccgtgtcc      600

aaggacacat ccaagaacca ggtgtccctg aagatgagct ctctgaccga tgcagacacg      660

gcccggtatt actgtgtcac cggcctgttc gactactggg gccagggcac caccctgacc      720

gtctcctcag aaagcaagta tggcccacct tgtccacctt gtcccgattt ttgggttctg      780

gtagttgtgg gaggtgttct cgcctgttat agtctcctcg ttactgtagc gttcatcatt      840

ttttgggtaa ggagtaagag gagcaggctc ctgcacagtg actacatgaa catgactcca      900

cgccgcccag gtcctacacg caagcattac cagccctatg ccccaccacg cgacttcgca      960

gcctatcgct ccaaacgggg cagaaagaaa ctcctgtata tattcaaaca accatttatg     1020

agaccagtac aaactactca agaggaagat ggctgtagct gccgatttcc agaagaagaa     1080

gaaggaggat gtgaactgag agtgaagttc agcaggagcg cagacgcccc cgcgtacaag     1140

cagggccaga accagctcta taacgagctc aatctaggac gaagagagga gtacgatgtt     1200

ttggacaaga gacgtggccg ggaccctgag atggggggaa agccgagaag gaagaaccct     1260

caggaaggcc tgtacaatga actgcagaaa gataagatgg cggaggccta cagtgagatt     1320

gggatgaaag gcgagcgccg gaggggcaag gggcacgatg gcctttacca gggtctcagt     1380

acagccacca aggacaccta cgacgccctt cacatgcagg ccctgccccc tcgc           1434


<210>  413
<211>  478
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - CAR construct

<400>  413

Gln Ala Val Val Thr Gln Glu Pro Ser Leu Thr Ser Ser Pro Gly Gly 
1               5                   10                  15      


Thr Val Thr Leu Thr Cys Gly Ser Ser Thr Gly Ala Val Thr Thr Ser 
            20                  25                  30          


Asn Tyr Ala Ser Trp Val Gln Glu Lys Pro Asp His Leu Phe Arg Gly 
        35                  40                  45              


Leu Ile Gly Gly Thr Asn Asn Arg Ala Pro Gly Val Pro Ala Arg Phe 
    50                  55                  60                  


Ser Gly Ser Leu Leu Gly Gly Lys Ala Ala Leu Thr Ile Ser Gly Ala 
65                  70                  75                  80  


Gln Pro Glu Asp Glu Ala Ile Tyr Phe Cys Val Leu Trp Tyr Ser Asp 
                85                  90                  95      


His Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Asp Gly Gly Gly 
            100                 105                 110         


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro 
    130                 135                 140                 


Ser Glu Thr Leu Ser Ile Thr Cys Thr Val Ser Gly Phe Leu Leu Thr 
145                 150                 155                 160 


Asp Tyr Gly Val Asn Trp Val Arg Gln Pro Pro Gly Lys Gly Leu Glu 
                165                 170                 175     


Trp Leu Gly Val Ile Trp Gly Asp Gly Ile Thr Asp Tyr Asn Pro Ser 
            180                 185                 190         


Leu Lys Ser Arg Leu Thr Val Ser Lys Asp Thr Ser Lys Asn Gln Val 
        195                 200                 205             


Ser Leu Lys Met Ser Ser Leu Thr Asp Ala Asp Thr Ala Arg Tyr Tyr 
    210                 215                 220                 


Cys Val Thr Gly Leu Phe Asp Tyr Trp Gly Gln Gly Thr Thr Leu Thr 
225                 230                 235                 240 


Val Ser Ser Glu Ser Lys Tyr Gly Pro Pro Cys Pro Pro Cys Pro Asp 
                245                 250                 255     


Phe Trp Val Leu Val Val Val Gly Gly Val Leu Ala Cys Tyr Ser Leu 
            260                 265                 270         


Leu Val Thr Val Ala Phe Ile Ile Phe Trp Val Arg Ser Lys Arg Ser 
        275                 280                 285             


Arg Leu Leu His Ser Asp Tyr Met Asn Met Thr Pro Arg Arg Pro Gly 
    290                 295                 300                 


Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro Pro Arg Asp Phe Ala 
305                 310                 315                 320 


Ala Tyr Arg Ser Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys 
                325                 330                 335     


Gln Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys 
            340                 345                 350         


Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg Val 
        355                 360                 365             


Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Lys Gln Gly Gln Asn 
    370                 375                 380                 


Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val 
385                 390                 395                 400 


Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg 
                405                 410                 415     


Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys 
            420                 425                 430         


Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg 
        435                 440                 445             


Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys 
    450                 455                 460                 


Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
465                 470                 475             


<210>  414
<211>  1434
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Made in Lab - CAR construct

<400>  414
caggctgtgg tgactcagga gccctcactg actagctccc caggagggac agtcactctc       60

acctgtggct ccagcactgg agctgtcacc acttccaact atgcctcatg ggtgcaggag      120

aagcctgacc acctcttcag ggggctgatt ggtggcacaa acaacagggc tcctggggtg      180

cctgcccggt tctcaggctc cctccttggg ggcaaagctg ccctgaccat ttcgggtgcg      240

cagcctgagg atgaggctat ttatttctgc gtgctctggt atagtgacca ttgggtgttc      300

ggcggaggga ccaagctgac cgtcgacggc ggaggaggag gttcaggagg cggaggtagc      360

gggggaggcg gttccggggg aggcggttct caggtgcagc tgcaggagtc gggcccagga      420

ctggtgaagc cttcggagac cctgtccatc acctgcactg tctctggttt cctgctgacc      480

gactacggcg taaactgggt gcggcagccc ccagggaagg gactggagtg gctgggggtg      540

atctggggtg acgggatcac cgactacaac ccctccctca agagtcgact gaccgtgtcc      600

aaggacacat ccaagaacca ggtgtccctg aagatgagct ctctgaccga tgcagacacg      660

gcccggtatt actgtgtcac cggcctgttc gactactggg gccagggcac caccctgacc      720

gtctcctcag aaagcaagta tggcccacct tgtccacctt gtcccgattt ttgggttctg      780

gtagttgtgg gaggtgttct cgcctgttat agtctcctcg ttactgtagc gttcatcatt      840

ttttgggtaa ggagtaagag gagcaggctc ctgcacagtg actacatgaa catgactcca      900

cgccgcccag gtcctacacg caagcattac cagccctatg ccccaccacg cgacttcgca      960

gcctatcgct ccaaacgggg cagaaagaaa ctcctgtata tattcaaaca accatttatg     1020

agaccagtac aaactactca agaggaagat ggctgtagct gccgatttcc agaagaagaa     1080

gaaggaggat gtgaactgag agtgaagttc agcaggagcg cagacgcccc cgcgtacaag     1140

cagggccaga accagctcta taacgagctc aatctaggac gaagagagga gtacgatgtt     1200

ttggacaaga gacgtggccg ggaccctgag atggggggaa agccgagaag gaagaaccct     1260

caggaaggcc tgtacaatga actgcagaaa gataagatgg cggaggccta cagtgagatt     1320

gggatgaaag gcgagcgccg gaggggcaag gggcacgatg gcctttacca gggtctcagt     1380

acagccacca aggacaccta cgacgccctt cacatgcagg ccctgccccc tcgc           1434


<210>  415
<211>  478
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - CAR construct

<400>  415

Gln Ala Val Val Thr Gln Glu Pro Ser Leu Thr Ser Ser Pro Gly Gly 
1               5                   10                  15      


Thr Val Thr Leu Thr Cys Gly Ser Ser Thr Gly Ala Val Thr Thr Ser 
            20                  25                  30          


Asn Tyr Ala Ser Trp Val Gln Glu Lys Pro Asp His Leu Phe Arg Gly 
        35                  40                  45              


Leu Ile Gly Gly Thr Asn Asn Arg Ala Pro Gly Val Pro Ala Arg Phe 
    50                  55                  60                  


Ser Gly Ser Leu Leu Gly Gly Lys Ala Ala Leu Thr Ile Ser Gly Ala 
65                  70                  75                  80  


Gln Pro Glu Asp Glu Ala Ile Tyr Phe Cys Val Leu Trp Tyr Ser Asp 
                85                  90                  95      


His Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Asp Gly Gly Gly 
            100                 105                 110         


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Gln Val Gln Leu Gln Gln Ser Gly Pro Gly Leu Val Lys Pro 
    130                 135                 140                 


Ser Glu Thr Leu Ser Ile Thr Cys Thr Val Ser Gly Phe Leu Leu Thr 
145                 150                 155                 160 


Asp Tyr Gly Val Asn Trp Val Arg Gln Pro Pro Gly Lys Gly Leu Glu 
                165                 170                 175     


Trp Leu Gly Val Ile Trp Gly Asp Gly Ile Thr Asp Tyr Asn Pro Ser 
            180                 185                 190         


Leu Lys Ser Arg Leu Thr Val Ser Lys Asp Thr Ser Lys Asn Gln Val 
        195                 200                 205             


Ser Leu Lys Met Ser Ser Leu Thr Asp Ala Asp Thr Ala Arg Tyr Tyr 
    210                 215                 220                 


Cys Val Thr Gly Leu Phe Asp Tyr Trp Gly Gln Gly Thr Thr Leu Thr 
225                 230                 235                 240 


Val Ser Ser Glu Ser Lys Tyr Gly Pro Pro Cys Pro Pro Cys Pro Asp 
                245                 250                 255     


Phe Trp Val Leu Val Val Val Gly Gly Val Leu Ala Cys Tyr Ser Leu 
            260                 265                 270         


Leu Val Thr Val Ala Phe Ile Ile Phe Trp Val Arg Ser Lys Arg Ser 
        275                 280                 285             


Arg Leu Leu His Ser Asp Tyr Met Asn Met Thr Pro Arg Arg Pro Gly 
    290                 295                 300                 


Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro Pro Arg Asp Phe Ala 
305                 310                 315                 320 


Ala Tyr Arg Ser Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys 
                325                 330                 335     


Gln Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys 
            340                 345                 350         


Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg Val 
        355                 360                 365             


Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Lys Gln Gly Gln Asn 
    370                 375                 380                 


Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val 
385                 390                 395                 400 


Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg 
                405                 410                 415     


Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys 
            420                 425                 430         


Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg 
        435                 440                 445             


Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys 
    450                 455                 460                 


Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
465                 470                 475             


<210>  416
<211>  1434
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Made in Lab - CAR construct

<400>  416
caggctgtgg tgactcagga gccctcactg actagctccc caggagggac agtcactctc       60

acctgtggct ccagcactgg agctgtcacc acttccaact atgcctcatg ggtgcaggag      120

aagcctgacc acctcttcag ggggctgatt ggtggcacaa acaacagggc tcctggggtg      180

cctgcccggt tctcaggctc cctccttggg ggcaaagctg ccctgaccat ttcgggtgcg      240

cagcctgagg atgaggctat ttatttctgc gtgctctggt atagtgacca ttgggtgttc      300

ggcggaggga ccaagctgac cgtcgacggc ggaggaggag gttcaggagg cggaggtagc      360

gggggaggcg gttccggggg aggcggttct caggtgcagc tgcagcagtc gggcccagga      420

ctggtgaagc cttcggagac cctgtccatc acctgcactg tctctggttt cctgctgacc      480

gactacggcg taaactgggt gcggcagccc ccagggaagg gactggagtg gctgggggtg      540

atctggggtg acgggatcac cgactacaac ccctccctca agagtcgact gaccgtgtcc      600

aaggacacat ccaagaacca ggtgtccctg aagatgagct ctctgaccga tgcagacacg      660

gcccggtatt actgtgtcac cggcctgttc gactactggg gccagggcac caccctgacc      720

gtctcctcag aaagcaagta tggcccacct tgtccacctt gtcccgattt ttgggttctg      780

gtagttgtgg gaggtgttct cgcctgttat agtctcctcg ttactgtagc gttcatcatt      840

ttttgggtaa ggagtaagag gagcaggctc ctgcacagtg actacatgaa catgactcca      900

cgccgcccag gtcctacacg caagcattac cagccctatg ccccaccacg cgacttcgca      960

gcctatcgct ccaaacgggg cagaaagaaa ctcctgtata tattcaaaca accatttatg     1020

agaccagtac aaactactca agaggaagat ggctgtagct gccgatttcc agaagaagaa     1080

gaaggaggat gtgaactgag agtgaagttc agcaggagcg cagacgcccc cgcgtacaag     1140

cagggccaga accagctcta taacgagctc aatctaggac gaagagagga gtacgatgtt     1200

ttggacaaga gacgtggccg ggaccctgag atggggggaa agccgagaag gaagaaccct     1260

caggaaggcc tgtacaatga actgcagaaa gataagatgg cggaggccta cagtgagatt     1320

gggatgaaag gcgagcgccg gaggggcaag gggcacgatg gcctttacca gggtctcagt     1380

acagccacca aggacaccta cgacgccctt cacatgcagg ccctgccccc tcgc           1434


<210>  417
<211>  27
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - CAR construct fragment

<400>  417

Phe Trp Val Leu Val Val Val Gly Gly Val Leu Ala Cys Tyr Ser Leu 
1               5                   10                  15      


Leu Val Thr Val Ala Phe Ile Ile Phe Trp Val 
            20                  25          


<210>  418
<211>  41
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - CAR construct fragment

<400>  418

Arg Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met Asn Met Thr 
1               5                   10                  15      


Pro Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro 
            20                  25                  30          


Pro Arg Asp Phe Ala Ala Tyr Arg Ser 
        35                  40      


<210>  419
<211>  42
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - CAR construct fragment

<400>  419

Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met 
1               5                   10                  15      


Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe 
            20                  25                  30          


Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu 
        35                  40          


<210>  420
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - CAR construct fragment

<400>  420

Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Lys Gln Gly 
1               5                   10                  15      


Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr 
            20                  25                  30          


Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys 
        35                  40                  45              


Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys 
    50                  55                  60                  


Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg 
65                  70                  75                  80  


Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala 
                85                  90                  95      


Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
            100                 105                 110         


<210>  421
<211>  39
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - CAR construct fragment

<400>  421

Ile Glu Val Met Tyr Pro Pro Pro Tyr Leu Asp Asn Glu Lys Ser Asn 
1               5                   10                  15      


Gly Thr Ile Ile His Val Lys Gly Lys His Leu Cys Pro Ser Pro Leu 
            20                  25                  30          


Phe Pro Gly Pro Ser Lys Pro 
        35                  


<210>  422
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - CAR construct fragment

<400>  422

Glu Ser Lys Tyr Gly Pro Pro Cys Pro Pro Cys Pro Asp 
1               5                   10              


<210>  423
<211>  243
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - Humanized scFv fragments

<400>  423

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Ile Thr Cys Thr Val Ser Gly Phe Leu Leu Thr Asp Tyr 
            20                  25                  30          


Gly Val Asn Trp Val Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Leu 
        35                  40                  45              


Gly Val Ile Trp Gly Asp Gly Ile Thr Asp Tyr Asn Pro Ser Leu Lys 
    50                  55                  60                  


Ser Arg Leu Thr Val Ser Lys Asp Thr Ser Lys Asn Gln Val Ser Leu 
65                  70                  75                  80  


Lys Met Ser Ser Leu Thr Ala Ala Asp Thr Ala Arg Tyr Tyr Cys Val 
                85                  90                  95      


Thr Gly Leu Phe Asp Tyr Trp Gly Gln Gly Thr Thr Leu Thr Val Ser 
            100                 105                 110         


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
        115                 120                 125             


Gly Gly Gly Gly Ser Gln Ala Val Val Thr Gln Glu Pro Ser Leu Thr 
    130                 135                 140                 


Ser Ser Pro Gly Gly Thr Val Thr Leu Thr Cys Gly Ser Ser Thr Gly 
145                 150                 155                 160 


Ala Val Thr Thr Ser Asn Tyr Ala Ser Trp Val Gln Glu Lys Pro Asp 
                165                 170                 175     


His Leu Phe Arg Gly Leu Ile Gly Gly Thr Asn Asn Arg Ala Pro Gly 
            180                 185                 190         


Val Pro Ala Arg Phe Ser Gly Ser Leu Leu Gly Gly Lys Ala Ala Leu 
        195                 200                 205             


Thr Ile Ser Gly Ala Gln Pro Glu Asp Glu Ala Ile Tyr Phe Cys Val 
    210                 215                 220                 


Leu Trp Tyr Ser Asp His Trp Val Phe Gly Gly Gly Thr Lys Leu Thr 
225                 230                 235                 240 


Val Leu Gly 
            


