                         SEQUENCE LISTING

<110>  City of Hope
 
<120>  USE OF TRIPLEX CMV VACCINE IN CAR T CELL THERAPY

<130>  40056-0030WO1

<140>  PCT/US2017/057433
<141>  2017-10-19

<150>  US 62/410,372
<151>  2016-10-19

<160>  31    

<170>  PatentIn version 3.5

<210>  1
<400>  1
000

<210>  2
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  linker

<400>  2

Gly Gly Gly Ser Ser Gly Gly Gly Ser Gly 
1               5                   10  


<210>  3
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IgG4 hinge with mutation (S228P)

<400>  3

Glu Ser Lys Tyr Gly Pro Pro Cys Pro Pro Cys Pro 
1               5                   10          


<210>  4
<211>  12
<212>  PRT
<213>  Homo sapiens

<400>  4

Glu Ser Lys Tyr Gly Pro Pro Cys Pro Ser Cys Pro 
1               5                   10          


<210>  5
<211>  22
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IgG4 hinge with mutation (S228P) + linker

<400>  5

Glu Ser Lys Tyr Gly Pro Pro Cys Pro Pro Cys Pro Gly Gly Gly Ser 
1               5                   10                  15      


Ser Gly Gly Gly Ser Gly 
            20          


<210>  6
<211>  39
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD28 hinge

<400>  6

Ile Glu Val Met Tyr Pro Pro Pro Tyr Leu Asp Asn Glu Lys Ser Asn 
1               5                   10                  15      


Gly Thr Ile Ile His Val Lys Gly Lys His Leu Cys Pro Ser Pro Leu 
            20                  25                  30          


Phe Pro Gly Pro Ser Lys Pro 
        35                  


<210>  7
<211>  48
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD8 hinge

<400>  7

Ala Lys Pro Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro 
1               5                   10                  15      


Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro 
            20                  25                  30          


Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp 
        35                  40                  45              


<210>  8
<211>  45
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD8 hinge

<400>  8

Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala 
1               5                   10                  15      


Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly 
            20                  25                  30          


Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp 
        35                  40                  45  


<210>  9
<211>  129
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IgG4(HL-CH3)(includes S228P in hinge)

<400>  9

Glu Ser Lys Tyr Gly Pro Pro Cys Pro Pro Cys Pro Gly Gly Gly Ser 
1               5                   10                  15      


Ser Gly Gly Gly Ser Gly Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr 
            20                  25                  30          


Leu Pro Pro Ser Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr 
        35                  40                  45              


Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu 
    50                  55                  60                  


Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu 
65                  70                  75                  80  


Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys 
                85                  90                  95      


Ser Arg Trp Gln Glu Gly Asn Val Phe Ser Cys Ser Val Met His Glu 
            100                 105                 110         


Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly 
        115                 120                 125             


Lys 
    


<210>  10
<211>  229
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IgG4(L235E,N297Q)

<400>  10

Glu Ser Lys Tyr Gly Pro Pro Cys Pro Ser Cys Pro Ala Pro Glu Phe 
1               5                   10                  15      


Glu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr 
            20                  25                  30          


Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val 
        35                  40                  45              


Ser Gln Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val 
    50                  55                  60                  


Glu Val His Gln Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Gln Ser 
65                  70                  75                  80  


Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu 
                85                  90                  95      


Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ser 
            100                 105                 110         


Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro 
        115                 120                 125             


Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met Thr Lys Asn Gln 
    130                 135                 140                 


Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala 
145                 150                 155                 160 


Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr 
                165                 170                 175     


Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu 
            180                 185                 190         


Thr Val Asp Lys Ser Arg Trp Gln Glu Gly Asn Val Phe Ser Cys Ser 
        195                 200                 205             


Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser 
    210                 215                 220                 


Leu Ser Leu Gly Lys 
225                 


<210>  11
<211>  229
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IgG4(S228P, L235E,N297Q)

<400>  11

Glu Ser Lys Tyr Gly Pro Pro Cys Pro Pro Cys Pro Ala Pro Glu Phe 
1               5                   10                  15      


Glu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr 
            20                  25                  30          


Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val 
        35                  40                  45              


Ser Gln Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val 
    50                  55                  60                  


Glu Val His Gln Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Gln Ser 
65                  70                  75                  80  


Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu 
                85                  90                  95      


Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ser 
            100                 105                 110         


Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro 
        115                 120                 125             


Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met Thr Lys Asn Gln 
    130                 135                 140                 


Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala 
145                 150                 155                 160 


Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr 
                165                 170                 175     


Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu 
            180                 185                 190         


Thr Val Asp Lys Ser Arg Trp Gln Glu Gly Asn Val Phe Ser Cys Ser 
        195                 200                 205             


Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser 
    210                 215                 220                 


Leu Ser Leu Gly Lys 
225                 


<210>  12
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IgG4(CH3)

<400>  12

Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu 
1               5                   10                  15      


Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe 
            20                  25                  30          


Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu 
        35                  40                  45              


Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe 
    50                  55                  60                  


Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg Trp Gln Glu Gly 
65                  70                  75                  80  


Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr 
                85                  90                  95      


Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly Lys 
            100                 105         


<210>  13
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD3z     J04132.1

<400>  13

Leu Cys Tyr Leu Leu Asp Gly Ile Leu Phe Ile Tyr Gly Val Ile Leu 
1               5                   10                  15      


Thr Ala Leu Phe Leu 
            20      


<210>  14
<211>  27
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD28    NM_006139

<400>  14

Phe Trp Val Leu Val Val Val Gly Gly Val Leu Ala Cys Tyr Ser Leu 
1               5                   10                  15      


Leu Val Thr Val Ala Phe Ile Ile Phe Trp Val 
            20                  25          


<210>  15
<211>  28
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD28(M)  NM_006139

<400>  15

Met Phe Trp Val Leu Val Val Val Gly Gly Val Leu Ala Cys Tyr Ser 
1               5                   10                  15      


Leu Leu Val Thr Val Ala Phe Ile Ile Phe Trp Val 
            20                  25              


<210>  16
<211>  22
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD4   M35160

<400>  16

Met Ala Leu Ile Val Leu Gly Gly Val Ala Gly Leu Leu Leu Phe Ile 
1               5                   10                  15      


Gly Leu Gly Ile Phe Phe 
            20          


<210>  17
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD8tm  NM_001768

<400>  17

Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu 
1               5                   10                  15      


Ser Leu Val Ile Thr 
            20      


<210>  18
<211>  23
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD8tm2 - NM_001768

<400>  18

Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu 
1               5                   10                  15      


Ser Leu Val Ile Thr Leu Tyr 
            20              


<210>  19
<211>  24
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD8tm3 - NM_001768

<400>  19

Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu 
1               5                   10                  15      


Ser Leu Val Ile Thr Leu Tyr Cys 
            20                  


<210>  20
<211>  27
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  41BB - NM_001561

<400>  20

Ile Ile Ser Phe Phe Leu Ala Leu Thr Ser Thr Ala Leu Leu Phe Leu 
1               5                   10                  15      


Leu Phe Phe Leu Thr Leu Arg Phe Ser Val Val 
            20                  25          


<210>  21
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD3    J04132.1

<400>  21

Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly 
1               5                   10                  15      


Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr 
            20                  25                  30          


Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys 
        35                  40                  45              


Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys 
    50                  55                  60                  


Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg 
65                  70                  75                  80  


Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala 
                85                  90                  95      


Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
            100                 105                 110         


<210>  22
<211>  41
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD28   NM_006139

<400>  22

Arg Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met Asn Met Thr 
1               5                   10                  15      


Pro Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro 
            20                  25                  30          


Pro Arg Asp Phe Ala Ala Tyr Arg Ser 
        35                  40      


<210>  23
<211>  41
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD28gg*  NM_006139

<400>  23

Arg Ser Lys Arg Ser Arg Gly Gly His Ser Asp Tyr Met Asn Met Thr 
1               5                   10                  15      


Pro Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro 
            20                  25                  30          


Pro Arg Asp Phe Ala Ala Tyr Arg Ser 
        35                  40      


<210>  24
<211>  42
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  41BB   NM_001561

<400>  24

Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met 
1               5                   10                  15      


Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe 
            20                  25                  30          


Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu 
        35                  40          


<210>  25
<211>  42
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  OX40

<400>  25

Ala Leu Tyr Leu Leu Arg Arg Asp Gln Arg Leu Pro Pro Asp Ala His 
1               5                   10                  15      


Lys Pro Pro Gly Gly Gly Ser Phe Arg Thr Pro Ile Gln Glu Glu Gln 
            20                  25                  30          


Ala Asp Ala His Ser Thr Leu Ala Lys Ile 
        35                  40          


<210>  26
<400>  26
000


<210>  27
<211>  24
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ribosomal skip sequence

<400>  27

Leu Glu Gly Gly Gly Glu Gly Arg Gly Ser Leu Leu Thr Cys Gly Asp 
1               5                   10                  15      


Val Glu Glu Asn Pro Gly Pro Arg 
            20                  


<210>  28
<211>  354
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  truncated EGFR

<400>  28

Leu Val Thr Ser Leu Leu Leu Cys Glu Leu Pro His Pro Ala Phe Leu 
1               5                   10                  15      


Leu Ile Pro Arg Lys Val Cys Asn Gly Ile Gly Ile Gly Glu Phe Lys 
            20                  25                  30          


Asp Ser Leu Ser Ile Asn Ala Thr Asn Ile Lys His Phe Lys Asn Cys 
        35                  40                  45              


Thr Ser Ile Ser Gly Asp Leu His Ile Leu Pro Val Ala Phe Arg Gly 
    50                  55                  60                  


Asp Ser Phe Thr His Thr Pro Pro Leu Asp Pro Gln Glu Leu Asp Ile 
65                  70                  75                  80  


Leu Lys Thr Val Lys Glu Ile Thr Gly Phe Leu Leu Ile Gln Ala Trp 
                85                  90                  95      


Pro Glu Asn Arg Thr Asp Leu His Ala Phe Glu Asn Leu Glu Ile Ile 
            100                 105                 110         


Arg Gly Arg Thr Lys Gln His Gly Gln Phe Ser Leu Ala Val Val Ser 
        115                 120                 125             


Leu Asn Ile Thr Ser Leu Gly Leu Arg Ser Leu Lys Glu Ile Ser Asp 
    130                 135                 140                 


Gly Asp Val Ile Ile Ser Gly Asn Lys Asn Leu Cys Tyr Ala Asn Thr 
145                 150                 155                 160 


Ile Asn Trp Lys Lys Leu Phe Gly Thr Ser Gly Gln Lys Thr Lys Ile 
                165                 170                 175     


Ile Ser Asn Arg Gly Glu Asn Ser Cys Lys Ala Thr Gly Gln Val Cys 
            180                 185                 190         


His Ala Leu Cys Ser Pro Glu Gly Cys Trp Gly Pro Glu Pro Arg Asp 
        195                 200                 205             


Cys Val Ser Cys Arg Asn Val Ser Arg Gly Arg Glu Cys Val Asp Lys 
    210                 215                 220                 


Cys Asn Leu Leu Glu Gly Glu Pro Arg Glu Phe Val Glu Asn Ser Glu 
225                 230                 235                 240 


Cys Ile Gln Cys His Pro Glu Cys Leu Pro Gln Ala Met Asn Ile Thr 
                245                 250                 255     


Cys Thr Gly Arg Gly Pro Asp Asn Cys Ile Gln Cys Ala His Tyr Ile 
            260                 265                 270         


Asp Gly Pro His Cys Val Lys Thr Cys Pro Ala Gly Val Met Gly Glu 
        275                 280                 285             


Asn Asn Thr Leu Val Trp Lys Tyr Ala Asp Ala Gly His Val Cys His 
    290                 295                 300                 


Leu Cys His Pro Asn Cys Thr Tyr Gly Cys Thr Gly Pro Gly Leu Glu 
305                 310                 315                 320 


Gly Cys Pro Thr Asn Gly Pro Lys Ile Pro Ser Ile Ala Thr Gly Met 
                325                 330                 335     


Val Gly Ala Leu Leu Leu Leu Leu Val Val Ala Leu Gly Ile Gly Leu 
            340                 345                 350         


Phe Met 
        


<210>  29
<211>  9388
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  mH5-IEfusion-pZWIIA (GUS) plasmid (SEQ ID NO:A)

<400>  29
cctcctgaaa aactggaatt taatacacca tttgtgttca tcatcagaca tgatattact       60

ggatttatat tgtttatggg taaggtagaa tctccttaat atgggtacgg tgtaaggaat      120

cattatttta tttatattga tgggtacgtg aaatctgaat tttcttaata aatattattt      180

ttattaaatg tgtatatgtt gttttgcgat agccatgtat ctactaatca gatctattag      240

agatattatt aattctggtg caatatgaca aaaattatac actaattagc gtctcgtttc      300

agacatggat ctgtcacgaa ttaatacttg gaagtctaag cagctgaaaa gctttctctc      360

tagcaaagat gcatttaagg cggatgtcca tggacatagt gccttgtatt atgcaatagc      420

tgataataac gtgcgtctag tatgtacgtt gttgaacgct ggagcattga aaaatcttct      480

agagaatgaa tttccattac atcaggcagc cacattggaa gataccaaaa tagtaaagat      540

tttggctatt cagtggactg gatgattcga ggtaccgact attgttctat attatatatg      600

gttgttgatg gatctgtgat gcatgcaata gctgataata gaacttacgc aaatattagc      660

aaaaatatat tagacaatac tacaattaac gatgagtgta gatgctgtta ttttgaacca      720

cagattagga ttcttgatag agatgagatg ctcaatggat catcgtgtga tatgaacaga      780

cattgtatta tgatgaattt acctgatgta ggcgaatttg gatctagtat gttggggaaa      840

tatgaacctg acatgattaa gattgctctt tcggtggctg ggtaccaggc gcgcatttca      900

ttttgttttt ttctatgcta taaatggtac gtcctgtaga aaccccaacc cgtgaaatca      960

aaaaactcga cggcctgtgg gcattcagtc tggatcgcga aaactgtgga attgatcagc     1020

gttggtggga aagcgcgtta caagaaagcc gggcaattgc tgtgccaggc agttttaacg     1080

atcagttcgc cgatgcagat attcgtaatt atgcgggcaa cgtctggtat cagcgcgaag     1140

tctttatacc gaaaggttgg gcaggccagc gtatcgtgct gcgtttcgat gcggtcactc     1200

attacggcaa agtgtgggtc aataatcagg aagtgatgga gcatcagggc ggctatacgc     1260

catttgaagc cgatgtcacg ccgtatgtta ttgccgggaa aagtgtacgt atcaccgttt     1320

gtgtgaacaa cgaactgaac tggcagacta tcccgccggg aatggtgatt accgacgaaa     1380

acggcaagaa aaagcagtct tacttccatg atttctttaa ctatgccgga atccatcgca     1440

gcgtaatgct ctacaccacg ccgaacacct gggtggacga tatcaccgtg gtgacgcatg     1500

tcgcgcaaga ctgtaaccac gcgtctgttg actggcaggt ggtggccaat ggtgatgtca     1560

gcgttgaact gcgtgatgcg gatcaacagg tggttgcaac tggacaaggc actagcggga     1620

ctttgcaagt ggtgaatccg cacctctggc aaccgggtga aggttatctc tatgaactgt     1680

gcgtcacagc caaaagccag acagagtgtg atatctaccc gcttcgcgtc ggcatccggt     1740

cagtggcagt gaagggcgaa cagttcctga ttaaccacaa accgttctac tttactggct     1800

ttggtcgtca tgaagatgcg gacttgcgtg gcaaaggatt cgataacgtg ctgatggtgc     1860

acgaccacgc attaatggac tggattgggg ccaactccta ccgtacctcg cattaccctt     1920

acgctgaaga gatgctcgac tgggcagatg aacatggcat cgtggtgatt gatgaaactg     1980

ctgctgtcgg ctttaacctc tctttaggca ttggtttcga agcgggcaac aagccgaaag     2040

aactgtacag cgaagaggca gtcaacgggg aaactcagca agcgcactta caggcgatta     2100

aagagctgat agcgcgtgac aaaaaccacc caagcgtggt gatgtggagt attgccaacg     2160

aaccggatac ccgtccgcaa ggtgcacggg aatatttcgc gccactggcg gaagcaacgc     2220

gtaaactcga cccgacgcgt ccgatcacct gcgtcaatgt aatgttctgc gacgctcaca     2280

ccgataccat cagcgatctc tttgatgtgc tgtgcctgaa ccgttattac ggatggtatg     2340

tccaaagcgg cgatttggaa acggcagaga aggtactgga aaaagaactt ctggcctggc     2400

aggagaaact gcatcagccg attatcatca ccgaatacgg cgtggatacg ttagccgggc     2460

tgcactcaat gtacaccgac atgtggagtg aagagtatca gtgtgcatgg ctggatatgt     2520

atcaccgcgt ctttgatcgc gtcagcgccg tcgtcggtga acaggtatgg aatttcgccg     2580

attttgcgac ctcgcaaggc atattgcgcg ttggcggtaa caagaaaggg atcttcactc     2640

gcgaccgcaa accgaagtcg gcggcttttc tgctgcaaaa acgctggact ggcatgaact     2700

tcggtgaaaa accgcagcag ggaggcaaac aatgagagct cggttgttga tggatctgtg     2760

atgcatgcaa tagctgataa tagaacttac gcaaatatta gcaaaaatat attagacaat     2820

actacaatta acgatgagtg tagatgctgt tattttgaac cacagattag gattcttgat     2880

agagatgaga tgctcaatgg atcatcgtgt gatatgaaca gacattgtat tatgatgaat     2940

ttacctgatg taggcgaatt tggatctagt atgttgggga aatatgaacc tgacatgatt     3000

aagattgctc tttcggtggc tggcggcccg ctcgagaaaa attgaaaata aatacaaagg     3060

ttcttgaggg ttgtgttaaa ttgaaagcga gaaataatca taaataagcc accaccgttt     3120

aaacgccacc acaatggtca aacagattaa ggttcgagtg gacatggtgc ggcatagaat     3180

caaggagcac atgctgaaaa aatataccca gacggaagag aaattcactg gcgcctttaa     3240

tatgatggga ggatgtttgc agaatgcctt agatatctta gataaggttc atgagccttt     3300

cgaggagatg aagtgtattg ggctaactat gcagagcatg tatgagaact acattgtacc     3360

tgaggataag cgggagatgt ggatggcttg tattaaggag ctgcatgatg tgagcaaggg     3420

cgccgctaac aagttggggg gtgcactgca ggctaaggcc cgtgctaaaa aggatgaact     3480

taggagaaag atgatgtata tgtgctacag gaatatagag ttctttacca agaactcagc     3540

cttccctaag accaccaatg gctgcagtca ggccatggcg gcactgcaga acttgcctca     3600

gtgctcccct gatgagatta tggcttatgc ccagaaaata tttaagattt tggatgagga     3660

gagagacaag gtgctcacgc acattgatca catatttatg gatatcctca ctacatgtgt     3720

ggaaacaatg tgtaatgagt acaaggtcac tagtgacgct tgtatgatga ccatgtacgg     3780

gggcatctct ctcttaagtg agttctgtcg ggtgctgtgc tgctatgtct tagaggagac     3840

tagtgtgatg ctggccaagc ggcctctgat aaccaagcct gaggttatca gtgtaatgaa     3900

gcgccgcatt gaggagatct gcatgaaggt ctttgcccag tacattctgg gggccgatcc     3960

tctgagagtc tgctctccta gtgtggatga cctacgggcc atcgccgagg agtcagatga     4020

ggaagaggct attgtagcct acactttggc caccgctggt gtcagctcct ctgattctct     4080

ggtgtcaccc ccagagtccc ctgtacccgc gactatccct ctgtcctcag taattgtggc     4140

tgagaacagt gatcaggaag aaagtgagca gagtgatgag gaagaggagg agggtgctca     4200

ggaggagcgg gaggacactg tgtctgtcaa gtctgagcca gtgtctgaga tagaggaagt     4260

tgccccagag gaagaggagg atggtgctga ggaacccacc gcctctggag gcaagagcac     4320

ccaccctatg gtgactagaa gcaaggctga ccagggtgac atcctcgccc aggctgtcaa     4380

tcatgccggt atcgattcca gtagcaccgg ccccacgctg acaacccact cttgcagcgt     4440

tagcagcgcc cctcttaaca agccgacccc caccagcgtc gcggttacta acactcctct     4500

ccccggggca tccgctactc ccgagctcag cccgcgtaag aaaccgcgca aaaccacgcg     4560

tcctttcaag gtgattatta aaccgcccgt gcctcccgcg cctatcatgc tgcccctcat     4620

caaacaggaa gacatcaagc ccgagcccga ctttaccatc cagtaccgca acaagattat     4680

cgataccgcc ggctgtatcg tgatctctga tagcgaggaa gaacagggtg aagaagtcga     4740

aacccgcggt gctaccgcgt cttccccttc caccggcagc ggcacgccgc gagtgacctc     4800

tcccacgcac ccgctctccc agatgaacca ccctcctctt cccgatccct tgggccggcc     4860

cgatgaagat agttcctctt cgtcttcctc ctcctgcagt tcggcttcgg actcggagag     4920

tgagtccgag gagatgaaat gcagcagtgg cggaggagca tccgtgacct cgagccacca     4980

tgggcgcggc ggttttggtg gcgcggcctc ctcctctctg ctgagctgcg gccatcagag     5040

cagcggcggg gcgagcaccg gaccccgcaa gaagaagagc aaacgcatct ccgagttgga     5100

caacgagaag gtgcgcaata tcatgaaaga taagaacacc cccttctgca cacccaacgt     5160

gcagactcgg cggggtcgcg tcaagattga cgaggtgagc cgcatgttcc gcaacaccaa     5220

tcgctctctt gagtacaaga acctgccctt cacgattccc agtatgcacc aggtgttaga     5280

tgaggccatc aaagcctgca aaaccatgca ggtgaacaac aagggcatcc agattatcta     5340

cacccgcaat catgaggtga agagtgaggt ggatgcggtg cggtgtcgcc tgggcaccat     5400

gtgcaacctg gccctctcca ctcccttcct catggagcac accatgcccg tgacacatcc     5460

acccgaagtg gcgcagcgca cagccgatgc ttgtaacgaa ggcgtcaagg ccgcgtggag     5520

cctcaaagaa ttgcacaccc accaattatg cccccgttcc tccgattacc gcaacatgat     5580

catccacgct gccacccccg tggacctgtt gggcgctctc aacctgtgcc tgcccctgat     5640

gcaaaagttt cccaaacagg tcatggtgcg catcttctcc accaaccagg gtgggttcat     5700

gctgcctatc tacgagacgg ccgcgaaggc ctacgccgtg gggcagtttg agcagcccac     5760

cgagacccct cccgaagacc tggacaccct gagcctggcc atcgaggcag ccatccagga     5820

cctgaggaac aagtctcagt aaaataaagg cgcgccataa aaatttttat actagtgtac     5880

cgcggtcgaa tcgatttaat taacgatgct agcattgtcg acggtggtgg cgcggccgcc     5940

agtgtgatgg atatctgcag aattcggctt ggggggctgc aggtggatgc gatcatgacg     6000

tcctctgcaa tggataacaa tgaacctaaa gtactagaaa tggtatatga tgctacaatt     6060

ttacccgaag gtagtagcat ggattgtata aacagacaca tcaatatgtg tatacaacgc     6120

acctatagtt ctagtataat tgccatattg gatagattcc taatgatgaa caaggatgaa     6180

ctaaataata cacagtgtca tataattaaa gaatttatga catacgaaca aatggcgatt     6240

gaccattatg gagaatatgt aaacgctatt ctatatcaaa ttcgtaaaag acctaatcaa     6300

catcacacca ttaatctgtt taaaaaaata aaaagaaccc ggtatgacac ttttaaagtg     6360

gatcccgtag aattcgtaaa aaaagttatc ggatttgtat ctatcttgaa caaatataaa     6420

ccggtttata gttacgtcct gtacgagaac gtcctgtacg atgagttcaa atgtttcatt     6480

gactacgtgg aaactaagta tttctaaaat taatgatgca ttaatttttg tattgattct     6540

caatcctaaa aactaaaata tgaataagta ttaaacatag cggtgtacta attgatttaa     6600

cataaaaaat agttgttaac taatcatgag gactctactt attagatata ttctttggag     6660

aaatgacaac gatcaaaccg ggcatgcaag cttgtctccc tatagtgagt cgtattagag     6720

cttggcgtaa tcatggtcat agctgtttcc tgtgtgaaat tgttatccgc tcacaattcc     6780

acacaacata cgagccggaa gcataaagtg taaagcctgg ggtgcctaat gagtgagcta     6840

actcacatta attgcgttgc gctcactgcc cgctttcgag tcgggaaacc tgtcgtgcca     6900

gctgcattaa tgaatcggcc aacgcgcggg gagaggcggt ttgcgtattg ggcgctcttc     6960

cgcttcctcg ctcactgact cgctgcgctc ggtcgttcgg ctgcggcgag cggtatcagc     7020

tcactcaaag gcggtaatac ggttatccac agaatcaggg gataacgcag gaaagaacat     7080

gtgagcaaaa ggccagcaaa aggccaggaa ccgtaaaaag gccgcgttgc tggcgttttt     7140

cgataggctc cgcccccctg acgagcatca caaaaatcga cgctcaagtc agaggtggcg     7200

aaacccgaca ggactataaa gataccaggc gtttccccct ggaagctccc tcgtgcgctc     7260

tcctgttccg accctgccgc ttaccggata cctgtccgcc tttctccctt cgggaagcgt     7320

ggcgctttct catagctcac gctgtaggta tctcagttcg gtgtaggtcg ttcgctccaa     7380

gctgggctgt gtgcacgaac cccccgttca gcccgaccgc tgcgccttat ccggtaacta     7440

tcgtcttgag tccaacccgg taagacacga cttatcgcca ctggcagcag ccactggtaa     7500

caggattagc agagcgaggt atgtaggcgg tgctacagag ttcttgaagt ggtggcctaa     7560

ctacggctac actagaagga cagtatttgg tatctgcgct ctgctgaagc cagttacctt     7620

cggaaaaaga gttggtagct cttgatccgg caaacaaacc accgctggta gcggtggttt     7680

ttttgtttgc aagcagcaga ttacgcgcag aaaaaaagga tctcaagaag atcctttgat     7740

cttttctacg gggtctgacg ctcagtggaa cgaaaactca cgttaaggga ttttggtcat     7800

gagattatca aaaaggatct tcacctagat ccttttaaat taaaaatgaa gttttaaatc     7860

aatctaaagt atatatgagt aaacttggtc tgacagttac caatgcttaa tcagtgaggc     7920

acctatctca gcgatctgtc tatttcgttc atccatagtt gcctgactcc ccgtcgtgta     7980

gataactacg atacgggagg gcttaccatc tggccccagt gctgcaatga taccgcgaga     8040

cccacgctca ccggctccag atttatcagc aataaaccag ccagccggaa gggccgagcg     8100

cagaagtggt cctgcaactt tatccgcctc catccagtct attaattgtt gccgggaagc     8160

tagagtaagt agttcgccag ttaatagttt gcgcaacgtt gttggcattg ctacaggcat     8220

cgtggtgtca cgctcgtcgt ttggtatggc ttcattcagc tccggttccc aacgatcaag     8280

gcgagttaca tgatccccca tgttgtgcaa aaaagcggtt agctccttcg gtcctccgat     8340

cgttgtcaga agtaagttgg ccgcagtgtt atcactcatg gttatggcag cactgcataa     8400

ttctcttact gtcatgccat ccgtaagatg cttttctgtg actggtgagt actcaaccaa     8460

gtcattctga gaatagtgta tgcggcgacc gagttgctct tgcccggcgt caatacggga     8520

taataccgcg ccacatagca gaactttaaa agtgctcatc attggaaaac gttcttcggg     8580

gcgaaaactc tcaaggatct taccgctgtt gagatccagt tcgatgtaac ccactcgtgc     8640

acccaactga tcttcagcat cttttacttt caccagcgtt tctgggtgag caaaaacagg     8700

aaggcaaaat gccgcaaaaa agggaataag ggcgacacgg aaatgttgaa tactcatact     8760

cttccttttt caatattatt gaagcattta tcagggttat tgtctcatga gcggatacat     8820

atttgaatgt atttagaaaa ataaacaaat aggggttccg cgcacatttc cccgaaaagt     8880

gccacctgac gtctaagaaa ccattattat catgacatta acctataaaa ataggcgtat     8940

cacgaggccc tttcgtctcg cgcgtttcgg tgatgacggt gaaaacctct gacacatgca     9000

gctcccggag acggtcacag cttgtctgta agcggatgcc gggagcagac aagcccgtca     9060

gggcgcgtca gcgggtgttg gcgggtgtcg gggctggctt aactatgcgg catcagagca     9120

gattgtactg agagtgcacc atatgcggtg tgaaataccg cacagatgcg taaggagaaa     9180

ataccgcatc aggcgccatt cgccattcag gctgcgcaac tgttgggaag ggcgatcggt     9240

gcgggcctct tcgctattac gccagctggc gaaaggggga tgtgctgcaa ggcgattaag     9300

ttgggtaacg ccagggtttt cccagtcacg acgttgtaaa acgacggcca gtgaattgga     9360

tttaggtgac actatagaat acgaattc                                        9388


<210>  30
<211>  8152
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  mH5-pp65-pLW51(GUS) plasmid (SEQ ID NO:B)

<400>  30
gaattcgttg gtggtcgcca tggatggtgt tattgtatac tgtctaaacg cgttagtaaa       60

acatggcgag gaaataaatc atataaaaaa tgatttcatg attaaaccat gttgtgaaaa      120

agtcaagaac gttcacattg gcggacaatc taaaaacaat acagtgattg cagatttgcc      180

atatatggat aatgcggtat ccgatgtatg caattcactg tataaaaaga atgtatcaag      240

aatatccaga tttgctaatt tgataaagat agatgacgat gacaagactc ctactggtgt      300

atataattat tttaaaccta aagatgccat tcctgttatt atatccatag gaaaggatag      360

agatgtttgt gaactattaa tctcatctga taaagcgtgt gcgtgtatag agttaaattc      420

atataaagta gccattcttc ccatggatgt ttcctttttt accaaaggaa atgcatcatt      480

gattattctc ctgtttgatt tctctatcga tgcggcacct ctcttaagaa gtgtaaccga      540

taataatgtt attatatcta gacaccagcg tctacatgac gagcttccga gttccaattg      600

gttcaagttt tacataagta taaagtccga ctattgttct atattatata tggttgttga      660

tggatctgtg atgcatgcaa tagctgataa tagaacttac gcaaatatta gcaaaaatat      720

attagacaat actacaatta acgatgagtg tagatgctgt tattttgaac cacagattag      780

gattcttgat agagatgaga tgctcaatgg atcatcgtgt gatatgaaca gacattgtat      840

tatgatgaat ttacctgatg taggcgaatt tggatctagt atgttgggga aatatgaacc      900

tgacatgatt aagattgctc tttcggtggc tgggtaccag gcgcgcattt cattttgttt      960

ttttctatgc tataaatggt acgtcctgta gaaaccccaa cccgtgaaat caaaaaactc     1020

gacggcctgt gggcattcag tctggatcgc gaaaactgtg gaattgatca gcgttggtgg     1080

gaaagcgcgt tacaagaaag ccgggcaatt gctgtgccag gcagttttaa cgatcagttc     1140

gccgatgcag atattcgtaa ttatgcgggc aacgtctggt atcagcgcga agtctttata     1200

ccgaaaggtt gggcaggcca gcgtatcgtg ctgcgtttcg atgcggtcac tcattacggc     1260

aaagtgtggg tcaataatca ggaagtgatg gagcatcagg gcggctatac gccatttgaa     1320

gccgatgtca cgccgtatgt tattgccggg aaaagtgtac gtatcaccgt ttgtgtgaac     1380

aacgaactga actggcagac tatcccgccg ggaatggtga ttaccgacga aaacggcaag     1440

aaaaagcagt cttacttcca tgatttcttt aactatgccg gaatccatcg cagcgtaatg     1500

ctctacacca cgccgaacac ctgggtggac gatatcaccg tggtgacgca tgtcgcgcaa     1560

gactgtaacc acgcgtctgt tgactggcag gtggtggcca atggtgatgt cagcgttgaa     1620

ctgcgtgatg cggatcaaca ggtggttgca actggacaag gcactagcgg gactttgcaa     1680

gtggtgaatc cgcacctctg gcaaccgggt gaaggttatc tctatgaact gtgcgtcaca     1740

gccaaaagcc agacagagtg tgatatctac ccgcttcgcg tcggcatccg gtcagtggca     1800

gtgaagggcg aacagttcct gattaaccac aaaccgttct actttactgg ctttggtcgt     1860

catgaagatg cggacttgcg tggcaaagga ttcgataacg tgctgatggt gcacgaccac     1920

gcattaatgg actggattgg ggccaactcc taccgtacct cgcattaccc ttacgctgaa     1980

gagatgctcg actgggcaga tgaacatggc atcgtggtga ttgatgaaac tgctgctgtc     2040

ggctttaacc tctctttagg cattggtttc gaagcgggca acaagccgaa agaactgtac     2100

agcgaagagg cagtcaacgg ggaaactcag caagcgcact tacaggcgat taaagagctg     2160

atagcgcgtg acaaaaacca cccaagcgtg gtgatgtgga gtattgccaa cgaaccggat     2220

acccgtccgc aaggtgcacg ggaatatttc gcgccactgg cggaagcaac gcgtaaactc     2280

gacccgacgc gtccgatcac ctgcgtcaat gtaatgttct gcgacgctca caccgatacc     2340

atcagcgatc tctttgatgt gctgtgcctg aaccgttatt acggatggta tgtccaaagc     2400

ggcgatttgg aaacggcaga gaaggtactg gaaaaagaac ttctggcctg gcaggagaaa     2460

ctgcatcagc cgattatcat caccgaatac ggcgtggata cgttagccgg gctgcactca     2520

atgtacaccg acatgtggag tgaagagtat cagtgtgcat ggctggatat gtatcaccgc     2580

gtctttgatc gcgtcagcgc cgtcgtcggt gaacaggtat ggaatttcgc cgattttgcg     2640

acctcgcaag gcatattgcg cgttggcggt aacaagaaag ggatcttcac tcgcgaccgc     2700

aaaccgaagt cggcggcttt tctgctgcaa aaacgctgga ctggcatgaa cttcggtgaa     2760

aaaccgcagc agggaggcaa acaatgagag ctcggttgtt gatggatctg tgatgcatgc     2820

aatagctgat aatagaactt acgcaaatat tagcaaaaat atattagaca atactacaat     2880

taacgatgag tgtagatgct gttattttga accacagatt aggattcttg atagagatga     2940

gatgctcaat ggatcatcgt gtgatatgaa cagacattgt attatgatga atttacctga     3000

tgtaggcgaa tttggatcta gtatgttggg gaaatatgaa cctgacatga ttaagattgc     3060

tctttcggtg gctggcggcc cgctcgagaa aaattgaaaa taaatacaaa ggttcttgag     3120

ggttgtgtta aattgaaagc gagaaataat cataaataag ccaccaccgt ttaaacagtc     3180

gacggtatcg ataagcttga tatcgaattc ctgcagcccg tacgcgcagg cagcatggag     3240

tcgcgcggtc gccgttgtcc cgaaatgata tccgtactgg gtcccatttc ggggcacgtg     3300

ctgaaagccg tgtttagtcg cggcgacacg ccggtgctgc cgcacgagac gcgactcctg     3360

cagacgggta tccacgtgcg cgtgagccag ccctcgctga tcctggtgtc gcagtacacg     3420

cccgactcga cgccatgcca ccgcggcgac aatcagctgc aggtgcagca cacgtacttt     3480

acgggcagcg aggtggagaa cgtgtcggtc aacgtgcaca accccacggg ccggagcatc     3540

tgccccagcc aagagcccat gtcgatctat gtgtacgcgc tgccgctcaa gatgctgaac     3600

atccccagca tcaacgtgca ccactacccg tcggcggccg agcgcaaaca ccgacacctg     3660

cccgtagctg acgctgtgat tcacgcgtcg ggcaagcaga tgtggcaggc gcgtctcacg     3720

gtctcgggac tggcctggac gcgtcagcag aaccagtgga aagagcccga cgtctactac     3780

acgtcagcgt tcgtgtttcc caccaaggac gtggcactgc ggcacgtggt gtgcgcgcac     3840

gagctggttt gctccatgga gaacacgcgc gcaaccaaga tgcaggtgat aggtgaccag     3900

tacgtcaagg tgtacctgga gtccttctgc gaggacgtgc cctccggcaa gctctttatg     3960

cacgtcacgc tgggctctga cgtggaagag gacctgacga tgacccgcaa cccgcaaccc     4020

ttcatgcgcc cccacgagcg caacggcttt acggtgttgt gtcccaaaaa tatgataatc     4080

aaaccgggca agatctcgca catcatgctg gatgtggctt ttacctcaca cgagcatttt     4140

gggctgctgt gtcccaagag catcccgggc ctgagcatct caggtaacct attgatgaac     4200

gggcagcaga tcttcctgga ggtgcaagcg atacgcgaga ccgtggaact gcgtcagtac     4260

gatcccgtgg ctgcgctctt ctttttcgat atcgacttgc tgctgcagcg cgggcctcag     4320

tacagcgaac accccacctt caccagccag tatcgcatcc agggcaagct tgagtaccga     4380

cacacctggg accggcacga cgagggtgcc gcccagggcg acgacgacgt ctggaccagc     4440

ggatcggact ccgacgagga actcgtaacc accgagcgca agacgccccg cgttaccggc     4500

ggcggcgcca tggcgggcgc ctccacttcc gcgggccgca aacgcaaatc agcatcctcg     4560

gcgacggcgt gcacggcggg cgttatgaca cgcggccgcc ttaaggccga gtccaccgtc     4620

gcgcccgaag aggacaccga cgaggattcc gacaacgaaa tccacaatcc ggccgtgttc     4680

acctggccgc cctggcaggc cggcatcctg gcccgcaacc tggtgcccat ggtggctacg     4740

gttcagggtc agaatctgaa gtaccaggag ttcttctggg acgccaacga catctaccgc     4800

atcttcgccg aattggaagg cgtatggcag cccgctgcgc aacccaaacg tcgccgccac     4860

cggcaagacg ccttgcccgg gccatgcatc gcctcgacgc ccaaaaagca ccgaggttga     4920

tttttatggc gcgccctgca gggaaagttt tataggtagt tgatagaaca aaatacataa     4980

ttttgtaaaa ataaatcact ttttatacta atatgacacg attaccaata cttttgttac     5040

taatatcatt agtatacgct acaccttttc ctcagacatc taaaaaaata ggtgatgatg     5100

caactttatc atgtaatcga aataatacaa atgactacgt tgttatgagt gcttggtata     5160

aggagcccaa ttccattatt cttttagctg ctaaaagcga cgtcttgtat tttgataatt     5220

ataccaagga taaaatatct tacgactctc catacgatga tctagttaca actatcacaa     5280

ttaaatcatt gactgctaga gatgccggta cttatgtatg tgcattcttt atgacatcgc     5340

ctacaaatga cactgataaa gtagattatg aagaatactc cacagagttg attgtaaata     5400

cagatagtga atcgactata gacataatac tatctggatc tacacattca ccagaaacta     5460

gttaagcttg tctccctata gtgagtcgta ttagagcttg gcgtaatcat ggtcatagct     5520

gtttcctgtg tgaaattgtt atccgctcac aattccacac aacatacgag ccggaagcat     5580

aaagtgtaaa gcctggggtg cctaatgagt gagctaactc acattaattg cgttgcgctc     5640

actgcccgct ttcgagtcgg gaaacctgtc gtgccagctg cattaatgaa tcggccaacg     5700

cgcggggaga ggcggtttgc gtattgggcg ctcttccgct tcctcgctca ctgactcgct     5760

gcgctcggtc gttcggctgc ggcgagcggt atcagctcac tcaaaggcgg taatacggtt     5820

atccacagaa tcaggggata acgcaggaaa gaacatgtga gcaaaaggcc agcaaaaggc     5880

caggaaccgt aaaaaggccg cgttgctggc gtttttcgat aggctccgcc cccctgacga     5940

gcatcacaaa aatcgacgct caagtcagag gtggcgaaac ccgacaggac tataaagata     6000

ccaggcgttt ccccctggaa gctccctcgt gcgctctcct gttccgaccc tgccgcttac     6060

cggatacctg tccgcctttc tcccttcggg aagcgtggcg ctttctcata gctcacgctg     6120

taggtatctc agttcggtgt aggtcgttcg ctccaagctg ggctgtgtgc acgaaccccc     6180

cgttcagccc gaccgctgcg ccttatccgg taactatcgt cttgagtcca acccggtaag     6240

acacgactta tcgccactgg cagcagccac tggtaacagg attagcagag cgaggtatgt     6300

aggcggtgct acagagttct tgaagtggtg gcctaactac ggctacacta gaaggacagt     6360

atttggtatc tgcgctctgc tgaagccagt taccttcgga aaaagagttg gtagctcttg     6420

atccggcaaa caaaccaccg ctggtagcgg tggttttttt gtttgcaagc agcagattac     6480

gcgcagaaaa aaaggatctc aagaagatcc tttgatcttt tctacggggt ctgacgctca     6540

gtggaacgaa aactcacgtt aagggatttt ggtcatgaga ttatcaaaaa ggatcttcac     6600

ctagatcctt ttaaattaaa aatgaagttt taaatcaatc taaagtatat atgagtaaac     6660

ttggtctgac agttaccaat gcttaatcag tgaggcacct atctcagcga tctgtctatt     6720

tcgttcatcc atagttgcct gactccccgt cgtgtagata actacgatac gggagggctt     6780

accatctggc cccagtgctg caatgatacc gcgagaccca cgctcaccgg ctccagattt     6840

atcagcaata aaccagccag ccggaagggc cgagcgcaga agtggtcctg caactttatc     6900

cgcctccatc cagtctatta attgttgccg ggaagctaga gtaagtagtt cgccagttaa     6960

tagtttgcgc aacgttgttg gcattgctac aggcatcgtg gtgtcacgct cgtcgtttgg     7020

tatggcttca ttcagctccg gttcccaacg atcaaggcga gttacatgat cccccatgtt     7080

gtgcaaaaaa gcggttagct ccttcggtcc tccgatcgtt gtcagaagta agttggccgc     7140

agtgttatca ctcatggtta tggcagcact gcataattct cttactgtca tgccatccgt     7200

aagatgcttt tctgtgactg gtgagtactc aaccaagtca ttctgagaat agtgtatgcg     7260

gcgaccgagt tgctcttgcc cggcgtcaat acgggataat accgcgccac atagcagaac     7320

tttaaaagtg ctcatcattg gaaaacgttc ttcggggcga aaactctcaa ggatcttacc     7380

gctgttgaga tccagttcga tgtaacccac tcgtgcaccc aactgatctt cagcatcttt     7440

tactttcacc agcgtttctg ggtgagcaaa aacaggaagg caaaatgccg caaaaaaggg     7500

aataagggcg acacggaaat gttgaatact catactcttc ctttttcaat attattgaag     7560

catttatcag ggttattgtc tcatgagcgg atacatattt gaatgtattt agaaaaataa     7620

acaaataggg gttccgcgca catttccccg aaaagtgcca cctgacgtct aagaaaccat     7680

tattatcatg acattaacct ataaaaatag gcgtatcacg aggccctttc gtctcgcgcg     7740

tttcggtgat gacggtgaaa acctctgaca catgcagctc ccggagacgg tcacagcttg     7800

tctgtaagcg gatgccggga gcagacaagc ccgtcagggc gcgtcagcgg gtgttggcgg     7860

gtgtcggggc tggcttaact atgcggcatc agagcagatt gtactgagag tgcaccatat     7920

gcggtgtgaa ataccgcaca gatgcgtaag gagaaaatac cgcatcaggc gccattcgcc     7980

attcaggctg cgcaactgtt gggaagggcg atcggtgcgg gcctcttcgc tattacgcca     8040

gctggcgaaa gggggatgtg ctgcaaggcg attaagttgg gtaacgccag ggttttccca     8100

gtcacgacgt tgtaaaacga cggccagtga attggattta ggtgacacta ta             8152


<210>  31
<211>  2709
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  IE1 antigen and the IE2 antigen fusion protein ((SEQ ID NO:C)

<400>  31
atggtcaaac agattaaggt tcgagtggac atggtgcggc atagaatcaa ggagcacatg       60

ctgaaaaaat atacccagac ggaagagaaa ttcactggcg cctttaatat gatgggagga      120

tgtttgcaga atgccttaga tatcttagat aaggttcatg agcctttcga ggagatgaag      180

tgtattgggc taactatgca gagcatgtat gagaactaca ttgtacctga ggataagcgg      240

gagatgtgga tggcttgtat taaggagctg catgatgtga gcaagggcgc cgctaacaag      300

ttggggggtg cactgcaggc taaggcccgt gctaaaaagg atgaacttag gagaaagatg      360

atgtatatgt gctacaggaa tatagagttc tttaccaaga actcagcctt ccctaagacc      420

accaatggct gcagtcaggc catggcggca ctgcagaact tgcctcagtg ctcccctgat      480

gagattatgg cttatgccca gaaaatattt aagattttgg atgaggagag agacaaggtg      540

ctcacgcaca ttgatcacat atttatggat atcctcacta catgtgtgga aacaatgtgt      600

aatgagtaca aggtcactag tgacgcttgt atgatgacca tgtacggggc atctctctct      660

taagtgagtt ctgtcgggtg ctgtgctgct atgtcttaga ggagactagt gtgatgctgg      720

ccaagcggcc tctgataacc aagcctgagg ttatcagtgt aatgaagcgc cgcattgagg      780

agatctgcat gaaggtcttt gcccagtaca ttctgggggc cgatcctctg agagtctgct      840

ctcctagtgt ggatgaccta cgggccatcg ccgaggagtc agatgaggaa gaggctattg      900

tagcctacac tttggccacc gctggtgtca gctcctctga ttctctggtg tcacccccag      960

agtcccctgt acccgcgact atccctctgt cctcagtaat tgtggctgag aacagtgatc     1020

aggaagaaag tgagcagagt gatgaggaag aggaggaggg tgctcaggag gagcgggagg     1080

acactgtgtc tgtcaagtct gagccagtgt ctgagataga ggaagttgcc ccagaggaag     1140

aggaggatgg tgctgaggaa cccaccgcct ctggaggcaa gagcacccac cctatggtga     1200

ctagaagcaa ggctgaccag ggtgacatcc tcgcccaggc tgtcaatcat gccggtatcg     1260

attccagtag caccggcccc acgctgacaa cccactcttg cagcgttagc agcgcccctc     1320

ttaacaagcc gacccccacc agcgtcgcgg ttactaacac tcctctcccc ggggcatccg     1380

ctactcccga gctcagcccg cgtaagaaac cgcgcaaaac cacgcgtcct ttcaaggtga     1440

ttattaaacc gcccgtgcct cccgcgccta tcatgctgcc cctcatcaaa caggaagaca     1500

tcaagcccga gcccgacttt accatccagt accgcaacaa gattatcgat accgccggct     1560

gtatcgtgat ctctgatagc gaggaagaac agggtgaaga agtcgaaacc cgcggtgcta     1620

ccgcgtcttc cccttccacc ggcagcggca cgccgcgagt gacctctccc acgcacccgc     1680

tctcccagat gaaccaccct cctcttcccg atcccttggg ccggcccgat gaagatagtt     1740

cctcttcgtc ttcctcctcc tgcagttcgg cttcggactc ggagagtgag tccgaggaga     1800

tgaaatgcag cagtggcgga ggagcatccg tgacctcgag ccaccatggg cgcggcggtt     1860

ttggtggcgc ggcctcctcc tctctgctga gctgcggcca tcagagcagc ggcggggcga     1920

gcaccggacc ccgcaagaag aagagcaaac gcatctccga gttggacaac gagaaggtgc     1980

gcaatatcat gaaagataag aacaccccct tctgcacacc caacgtgcag actcggcggg     2040

gtccgcgtca agattgacga ggtgagccgc atgttccgca acaccaatcg ctctcttgag     2100

tacaagaacc tgcccttcac gattcccagt atgcaccagg tgttagatga ggccatcaaa     2160

gcctgcaaaa ccatgcaggt gaacaacaag ggcatccaga ttatctacac ccgcaatcat     2220

gaggtgaaga gtgaggtgga tgcggtgcgg tgtcgcctgg gcaccatgtg caacctggcc     2280

ctctccactc ccttcctcat ggagcacacc atgcccgtga cacatccacc cgaagtggcg     2340

cagcgaacag ccgatgcttg taacgaaggc gtcaaggccg cgtggagcct caaagaattg     2400

cacacccacc aattatgccc ccgttcctcc gattaccgca acatgatcat ccacgctgcc     2460

acccccgtgg acctgttggg cgctctcaac ctgtgcctgc ccctgatgca aaagtttccc     2520

aaacaggtca tggtgcgcat cttctccacc aaccagggtg ggttcatgct gcctatctac     2580

gagacggccg cgaaggccta cgccgtgggg cagtttgagc agcccaccga gacccctccc     2640

gaagacctgg acaccctgag cctggccatc gaggcagcca tccaggacct gaggaacaag     2700

tctcagtaa                                                             2709


