                         SEQUENCE LISTING

<110>  AliveGen USA
 
<120>  NOVEL HYBRID ACTRIIB LIGAND TRAP PROTEINS FOR TREATING MUSCLE WASTING AND BONE DISEASE

<130>  CACAG1.0004

<160>  118   

<170>  PatentIn version 3.5

<210>  1
<211>  110
<212>  PRT
<213>  Homo sapiens

<400>  1

Glu Thr Arg Glu Cys Ile Tyr Tyr Asn Ala Asn Trp Glu Leu Glu Arg 
1               5                   10                  15      


Thr Asn Gln Ser Gly Leu Glu Arg Cys Glu Gly Glu Gln Asp Lys Arg 
            20                  25                  30          


Leu His Cys Tyr Ala Ser Trp Arg Asn Ser Ser Gly Thr Ile Glu Leu 
        35                  40                  45              


Val Lys Lys Gly Cys Trp Leu Asp Asp Phe Asn Cys Tyr Asp Arg Gln 
    50                  55                  60                  


Glu Cys Val Ala Thr Glu Glu Asn Pro Gln Val Tyr Phe Cys Cys Cys 
65                  70                  75                  80  


Glu Gly Asn Phe Cys Asn Glu Arg Phe Thr His Leu Pro Glu Ala Gly 
                85                  90                  95      


Gly Pro Glu Val Thr Tyr Glu Pro Pro Pro Thr Ala Pro Thr 
            100                 105                 110 


<210>  2
<211>  110
<212>  PRT
<213>  Homo sapiens

<400>  2

Glu Thr Gln Glu Cys Leu Phe Phe Asn Ala Asn Trp Glu Lys Asp Arg 
1               5                   10                  15      


Thr Asn Gln Thr Gly Val Glu Pro Cys Tyr Gly Asp Lys Asp Lys Arg 
            20                  25                  30          


Arg His Cys Phe Ala Thr Trp Lys Asn Ile Ser Gly Ser Ile Glu Ile 
        35                  40                  45              


Val Lys Gln Gly Cys Trp Leu Asp Asp Ile Asn Cys Tyr Asp Arg Thr 
    50                  55                  60                  


Asp Cys Val Glu Lys Lys Asp Ser Pro Glu Val Tyr Phe Cys Cys Cys 
65                  70                  75                  80  


Glu Gly Asn Met Cys Asn Glu Lys Phe Ser Tyr Phe Pro Glu Met Glu 
                85                  90                  95      


Val Thr Gln Pro Thr Ser Asn Pro Val Thr Pro Lys Pro Pro 
            100                 105                 110 


<210>  3
<211>  110
<212>  PRT
<213>  Artificial

<220>
<223>  Hybrid Human ActRIIB ECD

<400>  3

Glu Thr Arg Glu Cys Ile Tyr Tyr Asn Ala Asn Trp Glu Leu Glu Arg 
1               5                   10                  15      


Thr Asn Gln Ser Gly Leu Glu Arg Cys Tyr Gly Asp Lys Asp Lys Arg 
            20                  25                  30          


Arg His Cys Tyr Ala Ser Trp Arg Asn Ser Ser Gly Thr Ile Glu Leu 
        35                  40                  45              


Val Lys Lys Gly Cys Trp Leu Asp Asp Ile Asn Cys Tyr Asp Arg Thr 
    50                  55                  60                  


Asp Cys Val Glu Lys Lys Asp Ser Pro Glu Val Tyr Phe Cys Cys Cys 
65                  70                  75                  80  


Glu Gly Asn Phe Cys Asn Glu Arg Phe Thr His Leu Pro Glu Ala Gly 
                85                  90                  95      


Gly Pro Glu Val Thr Tyr Glu Pro Pro Pro Thr Ala Pro Thr 
            100                 105                 110 


<210>  4
<211>  110
<212>  PRT
<213>  Artificial

<220>
<223>  Hybrid Human ActRIIB ECD

<400>  4

Glu Thr Arg Glu Cys Ile Tyr Tyr Asn Ala Asn Trp Glu Leu Glu Arg 
1               5                   10                  15      


Thr Asn Gln Ser Gly Leu Glu Arg Cys Tyr Gly Asp Lys Asp Lys Arg 
            20                  25                  30          


Arg His Cys Tyr Ala Ser Trp Arg Asn Ser Ser Gly Thr Ile Glu Leu 
        35                  40                  45              


Val Lys Lys Gly Cys Trp Leu Asp Asp Phe Asn Cys Tyr Asp Arg Thr 
    50                  55                  60                  


Asp Cys Val Glu Lys Lys Asp Ser Pro Glu Val Tyr Phe Cys Cys Cys 
65                  70                  75                  80  


Glu Gly Asn Phe Cys Asn Glu Arg Phe Thr His Leu Pro Glu Ala Gly 
                85                  90                  95      


Gly Pro Glu Val Thr Tyr Glu Pro Pro Pro Thr Ala Pro Thr 
            100                 105                 110 


<210>  5
<211>  110
<212>  PRT
<213>  Artificial

<220>
<223>  Hybrid Human ActRIIB ECD

<400>  5

Glu Thr Arg Glu Cys Ile Tyr Tyr Asn Ala Asn Trp Glu Leu Glu Arg 
1               5                   10                  15      


Thr Asn Gln Ser Gly Leu Glu Arg Cys Glu Gly Glu Gln Asp Lys Arg 
            20                  25                  30          


Leu His Cys Tyr Ala Ser Trp Arg Asn Ser Ser Gly Thr Ile Glu Leu 
        35                  40                  45              


Val Lys Lys Gly Cys Trp Leu Asp Asp Ile Asn Cys Tyr Asp Arg Thr 
    50                  55                  60                  


Asp Cys Val Glu Lys Lys Asp Ser Pro Glu Val Tyr Phe Cys Cys Cys 
65                  70                  75                  80  


Glu Gly Asn Phe Cys Asn Glu Arg Phe Thr His Leu Pro Glu Ala Gly 
                85                  90                  95      


Gly Pro Glu Val Thr Tyr Glu Pro Pro Pro Thr Ala Pro Thr 
            100                 105                 110 


<210>  6
<211>  110
<212>  PRT
<213>  Artificial

<220>
<223>  Hybrid Human ActRIIB ECD

<400>  6

Glu Thr Arg Glu Cys Ile Tyr Tyr Asn Ala Asn Trp Glu Leu Glu Arg 
1               5                   10                  15      


Thr Asn Gln Ser Gly Leu Glu Arg Cys Glu Gly Glu Gln Asp Lys Arg 
            20                  25                  30          


Leu His Cys Tyr Ala Ser Trp Arg Asn Ser Ser Gly Thr Ile Glu Leu 
        35                  40                  45              


Val Lys Lys Gly Cys Trp Leu Asp Asp Ile Asn Cys Tyr Asp Arg Thr 
    50                  55                  60                  


Asp Cys Val Glu Lys Lys Asp Ser Pro Gln Val Tyr Phe Cys Cys Cys 
65                  70                  75                  80  


Glu Gly Asn Phe Cys Asn Glu Arg Phe Thr His Leu Pro Glu Ala Gly 
                85                  90                  95      


Gly Pro Glu Val Thr Tyr Glu Pro Pro Pro Thr Ala Pro Thr 
            100                 105                 110 


<210>  7
<211>  110
<212>  PRT
<213>  Artificial

<220>
<223>  Hybrid Human ActRIIB ECD

<400>  7

Glu Thr Arg Glu Cys Ile Tyr Tyr Asn Ala Asn Trp Glu Leu Glu Arg 
1               5                   10                  15      


Thr Asn Gln Ser Gly Leu Glu Arg Cys Glu Gly Glu Gln Asp Lys Arg 
            20                  25                  30          


Leu His Cys Tyr Ala Ser Trp Arg Asn Ser Ser Gly Thr Ile Glu Leu 
        35                  40                  45              


Val Lys Lys Gly Cys Trp Leu Asp Asp Phe Asn Cys Tyr Asp Arg Thr 
    50                  55                  60                  


Asp Cys Val Glu Lys Lys Asp Ser Pro Gln Val Tyr Phe Cys Cys Cys 
65                  70                  75                  80  


Glu Gly Asn Phe Cys Asn Glu Arg Phe Thr His Leu Pro Glu Ala Gly 
                85                  90                  95      


Gly Pro Glu Val Thr Tyr Glu Pro Pro Pro Thr Ala Pro Thr 
            100                 105                 110 


<210>  8
<211>  110
<212>  PRT
<213>  Artificial

<220>
<223>  Hybrid Human ActRIIB ECD

<400>  8

Glu Thr Arg Glu Cys Ile Tyr Tyr Asn Ala Asn Trp Glu Leu Glu Arg 
1               5                   10                  15      


Thr Asn Gln Ser Gly Leu Glu Arg Cys Glu Gly Glu Gln Asp Lys Arg 
            20                  25                  30          


Leu His Cys Tyr Ala Ser Trp Arg Asn Ser Ser Gly Thr Ile Glu Leu 
        35                  40                  45              


Val Lys Lys Gly Cys Trp Leu Asp Asp Phe Asn Cys Tyr Asp Arg Thr 
    50                  55                  60                  


Asp Cys Val Glu Lys Lys Asp Ser Pro Glu Val Tyr Phe Cys Cys Cys 
65                  70                  75                  80  


Glu Gly Asn Phe Cys Asn Glu Arg Phe Thr His Leu Pro Glu Ala Gly 
                85                  90                  95      


Gly Pro Glu Val Thr Tyr Glu Pro Pro Pro Thr Ala Pro Thr 
            100                 105                 110 


<210>  9
<211>  110
<212>  PRT
<213>  Artificial

<220>
<223>  Hybrid Human ActRIIB ECD

<400>  9

Glu Thr Arg Glu Cys Ile Tyr Tyr Asn Ala Asn Trp Glu Leu Glu Arg 
1               5                   10                  15      


Thr Asn Gln Ser Gly Leu Glu Arg Cys Glu Gly Glu Gln Asp Lys Arg 
            20                  25                  30          


Leu His Cys Tyr Ala Ser Trp Arg Asn Ser Ser Gly Thr Ile Glu Leu 
        35                  40                  45              


Val Lys Lys Gly Cys Trp Leu Asp Asp Phe Asn Cys Tyr Asp Arg Gln 
    50                  55                  60                  


Glu Cys Val Glu Lys Lys Asp Ser Pro Glu Val Tyr Phe Cys Cys Cys 
65                  70                  75                  80  


Glu Gly Asn Phe Cys Asn Glu Arg Phe Thr His Leu Pro Glu Ala Gly 
                85                  90                  95      


Gly Pro Glu Val Thr Tyr Glu Pro Pro Pro Thr Ala Pro Thr 
            100                 105                 110 


<210>  10
<211>  110
<212>  PRT
<213>  Artificial

<220>
<223>  Hybrid Human ActRIIB ECD

<400>  10

Glu Thr Arg Glu Cys Ile Tyr Tyr Asn Ala Asn Trp Glu Leu Glu Arg 
1               5                   10                  15      


Thr Asn Gln Ser Gly Leu Glu Arg Cys Glu Gly Glu Gln Asp Lys Arg 
            20                  25                  30          


Leu His Cys Tyr Ala Ser Trp Arg Asn Ser Ser Gly Thr Ile Glu Leu 
        35                  40                  45              


Val Lys Lys Gly Cys Trp Leu Asp Asp Phe Asn Cys Tyr Asp Arg Gln 
    50                  55                  60                  


Glu Cys Val Glu Lys Lys Asp Ser Pro Gln Val Tyr Phe Cys Cys Cys 
65                  70                  75                  80  


Glu Gly Asn Phe Cys Asn Glu Arg Phe Thr His Leu Pro Glu Ala Gly 
                85                  90                  95      


Gly Pro Glu Val Thr Tyr Glu Pro Pro Pro Thr Ala Pro Thr 
            100                 105                 110 


<210>  11
<211>  110
<212>  PRT
<213>  Artificial

<220>
<223>  Hybrid Human ActRIIB ECD

<400>  11

Glu Thr Arg Glu Cys Ile Tyr Tyr Asn Ala Asn Trp Glu Leu Glu Arg 
1               5                   10                  15      


Thr Asn Gln Ser Gly Leu Glu Arg Cys Glu Gly Glu Gln Asp Lys Arg 
            20                  25                  30          


Leu His Cys Tyr Ala Ser Trp Arg Asn Ser Ser Gly Thr Ile Glu Leu 
        35                  40                  45              


Val Lys Lys Gly Cys Trp Leu Asp Asp Ile Asn Cys Tyr Asp Arg Gln 
    50                  55                  60                  


Glu Cys Val Glu Lys Lys Asp Ser Pro Glu Val Tyr Phe Cys Cys Cys 
65                  70                  75                  80  


Glu Gly Asn Phe Cys Asn Glu Arg Phe Thr His Leu Pro Glu Ala Gly 
                85                  90                  95      


Gly Pro Glu Val Thr Tyr Glu Pro Pro Pro Thr Ala Pro Thr 
            100                 105                 110 


<210>  12
<211>  110
<212>  PRT
<213>  Artificial

<220>
<223>  Hybrid Human ActRIIB ECD

<400>  12

Glu Thr Arg Glu Cys Ile Tyr Tyr Asn Ala Asn Trp Glu Leu Glu Arg 
1               5                   10                  15      


Thr Asn Gln Ser Gly Leu Glu Arg Cys Glu Gly Glu Gln Asp Lys Arg 
            20                  25                  30          


Leu His Cys Tyr Ala Ser Trp Arg Asn Ser Ser Gly Thr Ile Glu Leu 
        35                  40                  45              


Val Lys Lys Gly Cys Trp Leu Asp Asp Phe Asn Cys Tyr Asp Arg Thr 
    50                  55                  60                  


Asp Cys Val Glu Lys Lys Asp Ser Pro Glu Val Tyr Phe Cys Cys Cys 
65                  70                  75                  80  


Glu Gly Asn Met Cys Asn Glu Arg Phe Thr His Leu Pro Glu Ala Gly 
                85                  90                  95      


Gly Pro Glu Val Thr Tyr Glu Pro Pro Pro Thr Ala Pro Thr 
            100                 105                 110 


<210>  13
<211>  110
<212>  PRT
<213>  Artificial

<220>
<223>  Hybrid Human ActRIIB ECD

<400>  13

Glu Thr Arg Glu Cys Ile Tyr Tyr Asn Ala Asn Trp Glu Leu Glu Arg 
1               5                   10                  15      


Thr Asn Gln Ser Gly Leu Glu Arg Cys Glu Gly Asp Gln Asp Lys Arg 
            20                  25                  30          


Leu His Cys Tyr Ala Ser Trp Arg Asn Ser Ser Gly Thr Ile Glu Leu 
        35                  40                  45              


Val Lys Lys Gly Cys Trp Leu Asp Asp Phe Asn Cys Tyr Asp Arg Gln 
    50                  55                  60                  


Glu Cys Val Glu Lys Lys Asp Ser Pro Glu Val Tyr Phe Cys Cys Cys 
65                  70                  75                  80  


Glu Gly Asn Met Cys Asn Glu Arg Phe Thr His Leu Pro Glu Ala Gly 
                85                  90                  95      


Gly Pro Glu Val Thr Tyr Glu Pro Pro Pro Thr Ala Pro Thr 
            100                 105                 110 


<210>  14
<211>  110
<212>  PRT
<213>  Artificial

<220>
<223>  Hybrid Human ActRIIB ECD

<400>  14

Glu Thr Gln Glu Cys Ile Tyr Tyr Asn Ala Asn Trp Glu Lys Asp Arg 
1               5                   10                  15      


Thr Asn Gln Thr Gly Val Glu Pro Cys Tyr Gly Asp Lys Asp Lys Arg 
            20                  25                  30          


Arg His Cys Tyr Ala Ser Trp Arg Asn Ser Ser Gly Thr Ile Glu Leu 
        35                  40                  45              


Val Lys Lys Gly Cys Trp Leu Asp Asp Phe Asn Cys Tyr Asp Arg Gln 
    50                  55                  60                  


Glu Cys Val Ala Thr Glu Glu Asn Pro Gln Val Tyr Phe Cys Cys Cys 
65                  70                  75                  80  


Glu Gly Asn Phe Cys Asn Glu Arg Phe Thr His Leu Pro Glu Ala Gly 
                85                  90                  95      


Gly Pro Glu Val Thr Tyr Glu Pro Pro Pro Thr Ala Pro Thr 
            100                 105                 110 


<210>  15
<211>  110
<212>  PRT
<213>  Artificial

<220>
<223>  Hybrid Human ActRIIB ECD

<400>  15

Glu Thr Gln Glu Cys Ile Tyr Tyr Asn Ala Asn Trp Glu Lys Asp Arg 
1               5                   10                  15      


Thr Asn Gln Thr Gly Val Glu Pro Cys Glu Gly Asp Gln Asp Lys Arg 
            20                  25                  30          


Leu His Cys Tyr Ala Ser Trp Arg Asn Ser Ser Gly Thr Ile Glu Leu 
        35                  40                  45              


Val Lys Lys Gly Cys Trp Leu Asp Asp Phe Asn Cys Tyr Asp Arg Gln 
    50                  55                  60                  


Glu Cys Val Ala Thr Glu Glu Asn Pro Gln Val Tyr Phe Cys Cys Cys 
65                  70                  75                  80  


Glu Gly Asn Phe Cys Asn Glu Arg Phe Thr His Leu Pro Glu Ala Gly 
                85                  90                  95      


Gly Pro Glu Val Thr Tyr Glu Pro Pro Pro Thr Ala Pro Thr 
            100                 105                 110 


<210>  16
<211>  110
<212>  PRT
<213>  Artificial

<220>
<223>  Hybrid Human ActRIIB ECD

<400>  16

Glu Thr Arg Glu Cys Ile Tyr Tyr Asn Ala Asn Trp Glu Leu Glu Arg 
1               5                   10                  15      


Thr Asn Gln Ser Gly Leu Glu Arg Cys Tyr Gly Asp Lys Asp Lys Arg 
            20                  25                  30          


Arg His Cys Tyr Ala Ser Trp Arg Asn Ser Ser Gly Thr Ile Glu Leu 
        35                  40                  45              


Val Lys Lys Gly Cys Trp Leu Asp Asp Phe Asn Cys Tyr Asp Arg Gln 
    50                  55                  60                  


Glu Cys Val Ala Thr Glu Glu Asn Pro Gln Val Tyr Phe Cys Cys Cys 
65                  70                  75                  80  


Glu Gly Asn Phe Cys Asn Glu Arg Phe Thr His Leu Pro Glu Ala Gly 
                85                  90                  95      


Gly Pro Glu Val Thr Tyr Glu Pro Pro Pro Thr Ala Pro Thr 
            100                 105                 110 


<210>  17
<211>  110
<212>  PRT
<213>  Artificial

<220>
<223>  Hybrid Human ActRIIB ECD

<400>  17

Glu Thr Arg Glu Cys Ile Tyr Tyr Asn Ala Asn Trp Glu Lys Asp Arg 
1               5                   10                  15      


Thr Asn Gln Thr Gly Val Glu Pro Cys Glu Gly Asp Gln Asp Lys Arg 
            20                  25                  30          


Leu His Cys Tyr Ala Ser Trp Arg Asn Ser Ser Gly Thr Ile Glu Leu 
        35                  40                  45              


Val Lys Lys Gly Cys Trp Leu Asp Asp Phe Asn Cys Tyr Asp Arg Gln 
    50                  55                  60                  


Glu Cys Val Ala Thr Glu Glu Asn Pro Gln Val Tyr Phe Cys Cys Cys 
65                  70                  75                  80  


Glu Gly Asn Phe Cys Asn Glu Arg Phe Thr His Leu Pro Glu Ala Gly 
                85                  90                  95      


Gly Pro Glu Val Thr Tyr Glu Pro Pro Pro Thr Ala Pro Thr 
            100                 105                 110 


<210>  18
<211>  110
<212>  PRT
<213>  Artificial

<220>
<223>  Hybrid Human ActRIIB ECD

<400>  18

Glu Thr Gln Glu Cys Ile Tyr Tyr Asn Ala Asn Trp Glu Lys Asp Arg 
1               5                   10                  15      


Thr Asn Gln Thr Gly Val Glu Pro Cys Glu Gly Asp Gln Asp Lys Arg 
            20                  25                  30          


Leu His Cys Tyr Ala Ser Trp Arg Asn Ser Ser Gly Thr Ile Glu Leu 
        35                  40                  45              


Val Lys Lys Gly Cys Trp Leu Asp Asp Phe Asn Cys Tyr Asp Arg Gln 
    50                  55                  60                  


Glu Cys Val Ala Thr Glu Glu Asn Pro Gln Val Tyr Phe Cys Cys Cys 
65                  70                  75                  80  


Glu Gly Asn Phe Cys Asn Glu Arg Phe Thr His Leu Pro Glu Ala Gly 
                85                  90                  95      


Gly Pro Glu Val Thr Tyr Glu Pro Pro Pro Thr Ala Pro Thr 
            100                 105                 110 


<210>  19
<211>  110
<212>  PRT
<213>  Artificial

<220>
<223>  Hybrid Human ActRIIB ECD

<400>  19

Glu Thr Gln Glu Cys Ile Tyr Tyr Asn Ala Asn Trp Glu Lys Asp Arg 
1               5                   10                  15      


Thr Asn Gln Thr Gly Leu Glu Arg Cys Glu Gly Glu Gln Asp Lys Arg 
            20                  25                  30          


Leu His Cys Tyr Ala Ser Trp Arg Asn Ser Ser Gly Thr Ile Glu Leu 
        35                  40                  45              


Val Lys Lys Gly Cys Trp Leu Asp Asp Phe Asn Cys Tyr Asp Arg Gln 
    50                  55                  60                  


Glu Cys Val Ala Thr Glu Glu Asn Pro Gln Val Tyr Phe Cys Cys Cys 
65                  70                  75                  80  


Glu Gly Asn Phe Cys Asn Glu Arg Phe Thr His Leu Pro Glu Ala Gly 
                85                  90                  95      


Gly Pro Glu Val Thr Tyr Glu Pro Pro Pro Thr Ala Pro Thr 
            100                 105                 110 


<210>  20
<211>  110
<212>  PRT
<213>  Artificial

<220>
<223>  Hybrid Human ActRIIB ECD

<400>  20

Glu Thr Gln Glu Cys Ile Tyr Tyr Asn Ala Asn Trp Glu Lys Asp Arg 
1               5                   10                  15      


Thr Asn Gln Ser Gly Leu Glu Arg Cys Glu Gly Glu Gln Asp Lys Arg 
            20                  25                  30          


Leu His Cys Tyr Ala Ser Trp Arg Asn Ser Ser Gly Thr Ile Glu Leu 
        35                  40                  45              


Val Lys Lys Gly Cys Trp Leu Asp Asp Phe Asn Cys Tyr Asp Arg Gln 
    50                  55                  60                  


Glu Cys Val Ala Thr Glu Glu Asn Pro Gln Val Tyr Phe Cys Cys Cys 
65                  70                  75                  80  


Glu Gly Asn Phe Cys Asn Glu Arg Phe Thr His Leu Pro Glu Ala Gly 
                85                  90                  95      


Gly Pro Glu Val Thr Tyr Glu Pro Pro Pro Thr Ala Pro Thr 
            100                 105                 110 


<210>  21
<211>  110
<212>  PRT
<213>  Artificial

<220>
<223>  Hybrid Human ActRIIB ECD

<400>  21

Glu Thr Arg Glu Cys Ile Tyr Tyr Asn Ala Asn Trp Glu Lys Asp Arg 
1               5                   10                  15      


Thr Asn Gln Ser Gly Leu Glu Arg Cys Glu Gly Glu Gln Asp Lys Arg 
            20                  25                  30          


Leu His Cys Tyr Ala Ser Trp Arg Asn Ser Ser Gly Thr Ile Glu Leu 
        35                  40                  45              


Val Lys Lys Gly Cys Trp Leu Asp Asp Phe Asn Cys Tyr Asp Arg Gln 
    50                  55                  60                  


Glu Cys Val Ala Thr Glu Glu Asn Pro Gln Val Tyr Phe Cys Cys Cys 
65                  70                  75                  80  


Glu Gly Asn Phe Cys Asn Glu Arg Phe Thr His Leu Pro Glu Ala Gly 
                85                  90                  95      


Gly Pro Glu Val Thr Tyr Glu Pro Pro Pro Thr Ala Pro Thr 
            100                 105                 110 


<210>  22
<211>  110
<212>  PRT
<213>  Artificial

<220>
<223>  Hybrid Human ActRIIB ECD

<400>  22

Glu Thr Gln Glu Cys Ile Tyr Tyr Asn Ala Asn Trp Glu Leu Glu Arg 
1               5                   10                  15      


Thr Asn Gln Ser Gly Leu Glu Arg Cys Glu Gly Glu Gln Asp Lys Arg 
            20                  25                  30          


Leu His Cys Tyr Ala Ser Trp Arg Asn Ser Ser Gly Thr Ile Glu Leu 
        35                  40                  45              


Val Lys Lys Gly Cys Trp Leu Asp Asp Phe Asn Cys Tyr Asp Arg Gln 
    50                  55                  60                  


Glu Cys Val Ala Thr Glu Glu Asn Pro Gln Val Tyr Phe Cys Cys Cys 
65                  70                  75                  80  


Glu Gly Asn Phe Cys Asn Glu Arg Phe Thr His Leu Pro Glu Ala Gly 
                85                  90                  95      


Gly Pro Glu Val Thr Tyr Glu Pro Pro Pro Thr Ala Pro Thr 
            100                 105                 110 


<210>  23
<211>  110
<212>  PRT
<213>  Artificial

<220>
<223>  Hybrid Human ActRIIB ECD

<400>  23

Glu Thr Arg Glu Cys Ile Tyr Tyr Asn Ala Asn Trp Glu Leu Glu Arg 
1               5                   10                  15      


Thr Asn Gln Ser Gly Leu Glu Arg Cys Glu Gly Glu Gln Asp Lys Arg 
            20                  25                  30          


Leu His Cys Phe Ala Thr Trp Arg Asn Ser Ser Gly Thr Ile Glu Leu 
        35                  40                  45              


Val Lys Gln Gly Cys Trp Leu Asp Asp Phe Asn Cys Tyr Asp Arg Gln 
    50                  55                  60                  


Glu Cys Val Ala Thr Glu Glu Asn Pro Gln Val Tyr Phe Cys Cys Cys 
65                  70                  75                  80  


Glu Gly Asn Phe Cys Asn Glu Arg Phe Thr His Leu Pro Glu Ala Gly 
                85                  90                  95      


Gly Pro Glu Val Thr Tyr Glu Pro Pro Pro Thr Ala Pro Thr 
            100                 105                 110 


<210>  24
<211>  110
<212>  PRT
<213>  Artificial

<220>
<223>  Hybrid Human ActRIIB ECD

<400>  24

Glu Thr Arg Glu Cys Ile Tyr Tyr Asn Ala Asn Trp Glu Leu Glu Arg 
1               5                   10                  15      


Thr Asn Gln Ser Gly Leu Glu Arg Cys Tyr Gly Asp Lys Asp Lys Arg 
            20                  25                  30          


Arg His Cys Tyr Ala Ser Trp Arg Asn Ser Ser Gly Thr Ile Glu Leu 
        35                  40                  45              


Val Lys Lys Gly Cys Trp Leu Asp Asp Ile Asn Cys Tyr Asp Arg Gln 
    50                  55                  60                  


Glu Cys Val Ala Thr Glu Glu Asn Pro Gln Val Tyr Phe Cys Cys Cys 
65                  70                  75                  80  


Glu Gly Asn Phe Cys Asn Glu Arg Phe Thr His Leu Pro Glu Ala Gly 
                85                  90                  95      


Gly Pro Glu Val Thr Tyr Glu Pro Pro Pro Thr Ala Pro Thr 
            100                 105                 110 


<210>  25
<211>  110
<212>  PRT
<213>  Artificial

<220>
<223>  Hybrid Human ActRIIB ECD

<400>  25

Glu Thr Arg Glu Cys Ile Tyr Tyr Asn Ala Asn Trp Glu Leu Glu Arg 
1               5                   10                  15      


Thr Asn Gln Ser Gly Leu Glu Arg Cys Glu Gly Glu Gln Asp Lys Arg 
            20                  25                  30          


Leu His Cys Tyr Ala Ser Trp Arg Asn Ser Ser Gly Thr Ile Glu Leu 
        35                  40                  45              


Val Lys Lys Gly Cys Trp Leu Asp Asp Phe Asn Cys Tyr Asp Arg Gln 
    50                  55                  60                  


Glu Cys Val Ala Thr Lys Glu Asn Pro Gln Val Tyr Phe Cys Cys Cys 
65                  70                  75                  80  


Glu Gly Asn Phe Cys Asn Glu Arg Phe Thr His Leu Pro Glu Ala Gly 
                85                  90                  95      


Gly Pro Glu Val Thr Tyr Glu Pro Pro Pro Thr Ala Pro Thr 
            100                 105                 110 


<210>  26
<211>  110
<212>  PRT
<213>  Artificial

<220>
<223>  Hybrid Human ActRIIB ECD

<400>  26

Glu Thr Arg Glu Cys Ile Tyr Tyr Asn Ala Asn Trp Glu Leu Glu Arg 
1               5                   10                  15      


Thr Asn Gln Ser Gly Leu Glu Arg Cys Glu Gly Glu Gln Asp Lys Arg 
            20                  25                  30          


Leu His Cys Tyr Ala Ser Trp Arg Asn Ser Ser Gly Thr Ile Glu Leu 
        35                  40                  45              


Val Lys Lys Gly Cys Trp Leu Asp Asp Ile Asn Cys Tyr Asp Arg Gln 
    50                  55                  60                  


Glu Cys Val Ala Thr Glu Glu Asn Pro Gln Val Tyr Phe Cys Cys Cys 
65                  70                  75                  80  


Glu Gly Asn Phe Cys Asn Glu Arg Phe Thr His Leu Pro Glu Ala Gly 
                85                  90                  95      


Gly Pro Glu Val Thr Tyr Glu Pro Pro Pro Thr Ala Pro Thr 
            100                 105                 110 


<210>  27
<211>  110
<212>  PRT
<213>  Artificial

<220>
<223>  Hybrid Human ActRIIB ECD

<400>  27

Glu Thr Arg Glu Cys Ile Tyr Tyr Asn Ala Asn Trp Glu Leu Glu Arg 
1               5                   10                  15      


Thr Asn Gln Ser Gly Leu Glu Arg Cys Glu Gly Glu Gln Asp Lys Arg 
            20                  25                  30          


Leu His Cys Tyr Ala Ser Trp Arg Asn Ser Ser Gly Thr Ile Glu Leu 
        35                  40                  45              


Val Lys Lys Gly Cys Trp Leu Asp Asp Ile Asn Cys Tyr Asp Arg Gln 
    50                  55                  60                  


Glu Cys Val Ala Thr Lys Glu Asn Pro Gln Val Tyr Phe Cys Cys Cys 
65                  70                  75                  80  


Glu Gly Asn Phe Cys Asn Glu Arg Phe Thr His Leu Pro Glu Ala Gly 
                85                  90                  95      


Gly Pro Glu Val Thr Tyr Glu Pro Pro Pro Thr Ala Pro Thr 
            100                 105                 110 


<210>  28
<211>  110
<212>  PRT
<213>  Artificial

<220>
<223>  Hybrid Human ActRIIB ECD

<400>  28

Glu Thr Arg Glu Cys Ile Tyr Tyr Asn Ala Asn Trp Glu Leu Glu Arg 
1               5                   10                  15      


Thr Asn Gln Ser Gly Leu Glu Arg Cys Glu Gly Asp Lys Asp Lys Arg 
            20                  25                  30          


Leu His Cys Tyr Ala Ser Trp Arg Asn Ser Ser Gly Thr Ile Glu Leu 
        35                  40                  45              


Val Lys Lys Gly Cys Trp Leu Asp Asp Ile Asn Cys Tyr Asp Arg Gln 
    50                  55                  60                  


Glu Cys Val Ala Thr Lys Glu Asn Pro Gln Val Tyr Phe Cys Cys Cys 
65                  70                  75                  80  


Glu Gly Asn Phe Cys Asn Glu Arg Phe Thr His Leu Pro Glu Ala Gly 
                85                  90                  95      


Gly Pro Glu Val Thr Tyr Glu Pro Pro Pro Thr Ala Pro Thr 
            100                 105                 110 


<210>  29
<211>  110
<212>  PRT
<213>  Artificial

<220>
<223>  Hybrid Human ActRIIB ECD

<400>  29

Glu Thr Arg Glu Cys Ile Tyr Tyr Asn Ala Asn Trp Glu Leu Glu Arg 
1               5                   10                  15      


Thr Asn Gln Ser Gly Leu Glu Arg Cys Glu Gly Asp Gln Asp Lys Arg 
            20                  25                  30          


Leu His Cys Tyr Ala Ser Trp Arg Asn Ser Ser Gly Thr Ile Glu Leu 
        35                  40                  45              


Val Lys Lys Gly Cys Trp Leu Asp Asp Ile Asn Cys Tyr Asp Arg Gln 
    50                  55                  60                  


Glu Cys Val Ala Thr Lys Glu Asn Pro Gln Val Tyr Phe Cys Cys Cys 
65                  70                  75                  80  


Glu Gly Asn Phe Cys Asn Glu Arg Phe Thr His Leu Pro Glu Ala Gly 
                85                  90                  95      


Gly Pro Glu Val Thr Tyr Glu Pro Pro Pro Thr Ala Pro Thr 
            100                 105                 110 


<210>  30
<211>  110
<212>  PRT
<213>  Artificial

<220>
<223>  Hybrid Human ActRIIB ECD

<400>  30

Glu Thr Arg Glu Cys Ile Tyr Tyr Asn Ala Asn Trp Glu Leu Glu Arg 
1               5                   10                  15      


Thr Asn Gln Ser Gly Leu Glu Arg Cys Glu Gly Asp Gln Asp Lys Arg 
            20                  25                  30          


Leu His Cys Tyr Ala Ser Trp Arg Asn Ser Ser Gly Thr Ile Glu Leu 
        35                  40                  45              


Val Lys Lys Gly Cys Trp Leu Asp Asp Phe Asn Cys Tyr Asp Arg Gln 
    50                  55                  60                  


Glu Cys Val Ala Thr Lys Glu Asn Pro Gln Val Tyr Phe Cys Cys Cys 
65                  70                  75                  80  


Glu Gly Asn Phe Cys Asn Glu Arg Phe Thr His Leu Pro Glu Ala Gly 
                85                  90                  95      


Gly Pro Glu Val Thr Tyr Glu Pro Pro Pro Thr Ala Pro Thr 
            100                 105                 110 


<210>  31
<211>  110
<212>  PRT
<213>  Artificial

<220>
<223>  Hybrid Human ActRIIB ECD

<400>  31

Glu Thr Arg Glu Cys Ile Tyr Tyr Asn Ala Asn Trp Glu Leu Glu Arg 
1               5                   10                  15      


Thr Asn Gln Ser Gly Leu Glu Arg Cys Glu Gly Asp Gln Asp Lys Arg 
            20                  25                  30          


Leu His Cys Tyr Ala Ser Trp Arg Asn Ser Ser Gly Thr Ile Glu Leu 
        35                  40                  45              


Val Lys Lys Gly Cys Trp Leu Asp Asp Phe Asn Cys Tyr Asp Arg Gln 
    50                  55                  60                  


Glu Cys Val Ala Thr Glu Glu Asn Pro Gln Val Tyr Phe Cys Cys Cys 
65                  70                  75                  80  


Glu Gly Asn Phe Cys Asn Glu Arg Phe Thr His Leu Pro Glu Ala Gly 
                85                  90                  95      


Gly Pro Glu Val Thr Tyr Glu Pro Pro Pro Thr Ala Pro Thr 
            100                 105                 110 


<210>  32
<211>  110
<212>  PRT
<213>  Artificial

<220>
<223>  Hybrid Human ActRIIB ECD

<400>  32

Glu Thr Arg Glu Cys Ile Tyr Tyr Asn Ala Asn Trp Glu Leu Glu Arg 
1               5                   10                  15      


Thr Asn Gln Ser Gly Leu Glu Arg Cys Tyr Gly Asp Lys Asp Lys Arg 
            20                  25                  30          


Arg His Cys Tyr Ala Ser Trp Arg Asn Ser Ser Gly Thr Ile Glu Leu 
        35                  40                  45              


Val Lys Lys Gly Cys Trp Leu Asp Asp Ile Asn Cys Tyr Asp Arg Gln 
    50                  55                  60                  


Glu Cys Val Glu Lys Lys Asp Ser Pro Glu Val Tyr Phe Cys Cys Cys 
65                  70                  75                  80  


Glu Gly Asn Phe Cys Asn Glu Arg Phe Thr His Leu Pro Glu Ala Gly 
                85                  90                  95      


Gly Pro Glu Val Thr Tyr Glu Pro Pro Pro Thr Ala Pro Thr 
            100                 105                 110 


<210>  33
<211>  110
<212>  PRT
<213>  Artificial

<220>
<223>  Hybrid Human ActRIIB ECD

<400>  33

Glu Thr Arg Glu Cys Ile Phe Phe Asn Ala Asn Trp Glu Lys Asp Arg 
1               5                   10                  15      


Thr Asn Gln Thr Gly Val Glu Pro Cys Glu Gly Glu Gln Asp Lys Arg 
            20                  25                  30          


Leu His Cys Tyr Ala Ser Trp Arg Asn Ser Ser Gly Thr Ile Glu Leu 
        35                  40                  45              


Val Lys Lys Gly Cys Trp Leu Asp Asp Phe Asn Cys Tyr Asp Arg Gln 
    50                  55                  60                  


Glu Cys Val Ala Thr Glu Glu Asn Pro Gln Val Tyr Phe Cys Cys Cys 
65                  70                  75                  80  


Glu Gly Asn Phe Cys Asn Glu Arg Phe Thr His Leu Pro Glu Ala Gly 
                85                  90                  95      


Gly Pro Glu Val Thr Tyr Glu Pro Pro Pro Thr Ala Pro Thr 
            100                 105                 110 


<210>  34
<211>  110
<212>  PRT
<213>  Artificial

<220>
<223>  Hybrid Human ActRIIB ECD

<400>  34

Glu Thr Arg Glu Cys Ile Tyr Tyr Asn Ala Asn Trp Glu Leu Glu Arg 
1               5                   10                  15      


Thr Asn Gln Ser Gly Leu Glu Arg Cys Glu Gly Glu Gln Asp Lys Arg 
            20                  25                  30          


Leu His Cys Phe Ala Thr Trp Lys Asn Ile Ser Gly Ser Ile Glu Leu 
        35                  40                  45              


Val Lys Gln Gly Cys Trp Leu Asp Asp Phe Asn Cys Tyr Asp Arg Gln 
    50                  55                  60                  


Glu Cys Val Ala Thr Glu Glu Asn Pro Gln Val Tyr Phe Cys Cys Cys 
65                  70                  75                  80  


Glu Gly Asn Phe Cys Asn Glu Arg Phe Thr His Leu Pro Glu Ala Gly 
                85                  90                  95      


Gly Pro Glu Val Thr Tyr Glu Pro Pro Pro Thr Ala Pro Thr 
            100                 105                 110 


<210>  35
<211>  110
<212>  PRT
<213>  Artificial

<220>
<223>  Hybrid Human ActRIIB ECD

<400>  35

Glu Thr Arg Glu Cys Ile Tyr Tyr Asn Ala Asn Trp Glu Leu Glu Arg 
1               5                   10                  15      


Thr Asn Gln Ser Gly Leu Glu Arg Cys Glu Gly Glu Gln Asp Lys Arg 
            20                  25                  30          


Leu His Cys Tyr Ala Ser Trp Arg Asn Ser Ser Gly Thr Ile Glu Leu 
        35                  40                  45              


Val Lys Lys Gly Cys Trp Leu Asp Asp Phe Asn Cys Tyr Asp Arg Thr 
    50                  55                  60                  


Asp Cys Val Ala Thr Glu Glu Asn Pro Gln Val Tyr Phe Cys Cys Cys 
65                  70                  75                  80  


Glu Gly Asn Phe Cys Asn Glu Arg Phe Thr His Leu Pro Glu Ala Gly 
                85                  90                  95      


Gly Pro Glu Val Thr Tyr Glu Pro Pro Pro Thr Ala Pro Thr 
            100                 105                 110 


<210>  36
<211>  110
<212>  PRT
<213>  Artificial

<220>
<223>  Hybrid Human ActRIIB ECD

<400>  36

Glu Thr Arg Glu Cys Ile Tyr Tyr Asn Ala Asn Trp Glu Leu Glu Arg 
1               5                   10                  15      


Thr Asn Gln Ser Gly Leu Glu Arg Cys Glu Gly Glu Gln Asp Lys Arg 
            20                  25                  30          


Leu His Cys Tyr Ala Ser Trp Arg Asn Ser Ser Gly Thr Ile Glu Leu 
        35                  40                  45              


Val Lys Lys Gly Cys Trp Leu Asp Asp Phe Asn Cys Tyr Asp Arg Gln 
    50                  55                  60                  


Glu Cys Val Ala Thr Glu Glu Asn Pro Gln Val Tyr Phe Cys Cys Cys 
65                  70                  75                  80  


Glu Gly Asn Met Cys Asn Glu Arg Phe Thr His Leu Pro Glu Ala Gly 
                85                  90                  95      


Gly Pro Glu Val Thr Tyr Glu Pro Pro Pro Thr Ala Pro Thr 
            100                 105                 110 


<210>  37
<211>  110
<212>  PRT
<213>  Artificial

<220>
<223>  Hybrid Human ActRIIB ECD

<400>  37

Glu Thr Arg Glu Cys Ile Tyr Tyr Asn Ala Asn Trp Glu Leu Glu Arg 
1               5                   10                  15      


Thr Asn Gln Ser Gly Leu Glu Arg Cys Glu Gly Asp Gln Asp Lys Arg 
            20                  25                  30          


Leu His Cys Tyr Ala Ser Trp Arg Asn Ser Ser Gly Thr Ile Glu Leu 
        35                  40                  45              


Val Lys Lys Gly Cys Trp Leu Asp Asp Ile Asn Cys Tyr Asp Arg Gln 
    50                  55                  60                  


Glu Cys Val Ala Thr Glu Glu Asn Pro Gln Val Tyr Phe Cys Cys Cys 
65                  70                  75                  80  


Glu Gly Asn Phe Cys Asn Glu Arg Phe Thr His Leu Pro Glu Ala Gly 
                85                  90                  95      


Gly Pro Glu Val Thr Tyr Glu Pro Pro Pro Thr Ala Pro Thr 
            100                 105                 110 


<210>  38
<211>  330
<212>  PRT
<213>  Homo sapiens

<400>  38

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys 
1               5                   10                  15      


Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 
65                  70                  75                  80  


Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys 
            100                 105                 110         


Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 
        115                 120                 125             


Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
    130                 135                 140                 


Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 
145                 150                 155                 160 


Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
                165                 170                 175     


Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
            180                 185                 190         


His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
        195                 200                 205             


Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
    210                 215                 220                 


Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu 
225                 230                 235                 240 


Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 
                245                 250                 255     


Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
            260                 265                 270         


Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
        275                 280                 285             


Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 
    290                 295                 300                 


Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
305                 310                 315                 320 


Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
                325                 330 


<210>  39
<211>  208
<212>  PRT
<213>  Homo sapiens

<400>  39

Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg 
1               5                   10                  15      


Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro 
            20                  25                  30          


Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala 
        35                  40                  45              


Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val 
    50                  55                  60                  


Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr 
65                  70                  75                  80  


Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr 
                85                  90                  95      


Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu 
            100                 105                 110         


Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys 
        115                 120                 125             


Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser 
    130                 135                 140                 


Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp 
145                 150                 155                 160 


Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser 
                165                 170                 175     


Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala 
            180                 185                 190         


Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
        195                 200                 205             


<210>  40
<211>  326
<212>  PRT
<213>  Homo sapiens

<400>  40

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Cys Ser Arg 
1               5                   10                  15      


Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Asn Phe Gly Thr Gln Thr 
65                  70                  75                  80  


Tyr Thr Cys Asn Val Asp His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Thr Val Glu Arg Lys Cys Cys Val Glu Cys Pro Pro Cys Pro Ala Pro 
            100                 105                 110         


Pro Val Ala Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp 
        115                 120                 125             


Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp 
    130                 135                 140                 


Val Ser His Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly 
145                 150                 155                 160 


Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn 
                165                 170                 175     


Ser Thr Phe Arg Val Val Ser Val Leu Thr Val Val His Gln Asp Trp 
            180                 185                 190         


Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro 
        195                 200                 205             


Ala Pro Ile Glu Lys Thr Ile Ser Lys Thr Lys Gly Gln Pro Arg Glu 
    210                 215                 220                 


Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn 
225                 230                 235                 240 


Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile 
                245                 250                 255     


Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr 
            260                 265                 270         


Thr Pro Pro Met Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys 
        275                 280                 285             


Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys 
    290                 295                 300                 


Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu 
305                 310                 315                 320 


Ser Leu Ser Pro Gly Lys 
                325     


<210>  41
<211>  207
<212>  PRT
<213>  Homo sapiens

<400>  41

Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg 
1               5                   10                  15      


Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro 
            20                  25                  30          


Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala 
        35                  40                  45              


Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Phe Arg Val Val 
    50                  55                  60                  


Ser Val Leu Thr Val Val His Gln Asp Trp Leu Asn Gly Lys Glu Tyr 
65                  70                  75                  80  


Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ala Pro Ile Glu Lys Thr 
                85                  90                  95      


Ile Ser Lys Thr Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu 
            100                 105                 110         


Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys 
        115                 120                 125             


Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser 
    130                 135                 140                 


Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Met Leu Asp 
145                 150                 155                 160 


Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser 
                165                 170                 175     


Arg Trp Gln Gln Gly Asn Val Phe Cys Ser Val Met His Glu Ala Leu 
            180                 185                 190         


His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
        195                 200                 205         


<210>  42
<211>  327
<212>  PRT
<213>  Homo sapiens

<400>  42

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Cys Ser Arg 
1               5                   10                  15      


Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Lys Thr 
65                  70                  75                  80  


Tyr Thr Cys Asn Val Asp His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Arg Val Glu Ser Lys Tyr Gly Pro Pro Cys Pro Ser Cys Pro Ala Pro 
            100                 105                 110         


Glu Phe Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys 
        115                 120                 125             


Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val 
    130                 135                 140                 


Asp Val Ser Gln Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp 
145                 150                 155                 160 


Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe 
                165                 170                 175     


Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp 
            180                 185                 190         


Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu 
        195                 200                 205             


Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg 
    210                 215                 220                 


Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met Thr Lys 
225                 230                 235                 240 


Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp 
                245                 250                 255     


Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys 
            260                 265                 270         


Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser 
        275                 280                 285             


Arg Leu Thr Val Asp Lys Ser Arg Trp Gln Glu Gly Asn Val Phe Ser 
    290                 295                 300                 


Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser 
305                 310                 315                 320 


Leu Ser Leu Ser Leu Gly Lys 
                325         


<210>  43
<211>  217
<212>  PRT
<213>  Homo sapiens

<400>  43

Ala Pro Glu Phe Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys 
1               5                   10                  15      


Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val 
            20                  25                  30          


Val Val Asp Val Ser Gln Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr 
        35                  40                  45              


Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu 
    50                  55                  60                  


Gln Phe Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His 
65                  70                  75                  80  


Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys 
                85                  90                  95      


Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln 
            100                 105                 110         


Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met 
        115                 120                 125             


Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro 
    130                 135                 140                 


Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn 
145                 150                 155                 160 


Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu 
                165                 170                 175     


Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg Trp Gln Glu Gly Asn Val 
            180                 185                 190         


Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln 
        195                 200                 205             


Lys Ser Leu Ser Leu Ser Leu Gly Lys 
    210                 215         


<210>  44
<211>  5
<212>  PRT
<213>  Artificial

<220>
<223>  Peptide linker

<400>  44

Gly Gly Gly Gly Ser 
1               5   


<210>  45
<211>  512
<212>  PRT
<213>  Homo sapiens

<400>  45

Met Thr Ala Pro Trp Val Ala Leu Ala Leu Leu Trp Gly Ser Leu Cys 
1               5                   10                  15      


Ala Gly Ser Gly Arg Gly Glu Ala Glu Thr Arg Glu Cys Ile Tyr Tyr 
            20                  25                  30          


Asn Ala Asn Trp Glu Leu Glu Arg Thr Asn Gln Ser Gly Leu Glu Arg 
        35                  40                  45              


Cys Glu Gly Glu Gln Asp Lys Arg Leu His Cys Tyr Ala Ser Trp Arg 
    50                  55                  60                  


Asn Ser Ser Gly Thr Ile Glu Leu Val Lys Lys Gly Cys Trp Leu Asp 
65                  70                  75                  80  


Asp Phe Asn Cys Tyr Asp Arg Gln Glu Cys Val Ala Thr Glu Glu Asn 
                85                  90                  95      


Pro Gln Val Tyr Phe Cys Cys Cys Glu Gly Asn Phe Cys Asn Glu Arg 
            100                 105                 110         


Phe Thr His Leu Pro Glu Ala Gly Gly Pro Glu Val Thr Tyr Glu Pro 
        115                 120                 125             


Pro Pro Thr Ala Pro Thr Leu Leu Thr Val Leu Ala Tyr Ser Leu Leu 
    130                 135                 140                 


Pro Ile Gly Gly Leu Ser Leu Ile Val Leu Leu Ala Phe Trp Met Tyr 
145                 150                 155                 160 


Arg His Arg Lys Pro Pro Tyr Gly His Val Asp Ile His Glu Asp Pro 
                165                 170                 175     


Gly Pro Pro Pro Pro Ser Pro Leu Val Gly Leu Lys Pro Leu Gln Leu 
            180                 185                 190         


Leu Glu Ile Lys Ala Arg Gly Arg Phe Gly Cys Val Trp Lys Ala Gln 
        195                 200                 205             


Leu Met Asn Asp Phe Val Ala Val Lys Ile Phe Pro Leu Gln Asp Lys 
    210                 215                 220                 


Gln Ser Trp Gln Ser Glu Arg Glu Ile Phe Ser Thr Pro Gly Met Lys 
225                 230                 235                 240 


His Glu Asn Leu Leu Gln Phe Ile Ala Ala Glu Lys Arg Gly Ser Asn 
                245                 250                 255     


Leu Glu Val Glu Leu Trp Leu Ile Thr Ala Phe His Asp Lys Gly Ser 
            260                 265                 270         


Leu Thr Asp Tyr Leu Lys Gly Asn Ile Ile Thr Trp Asn Glu Leu Cys 
        275                 280                 285             


His Val Ala Glu Thr Met Ser Arg Gly Leu Ser Tyr Leu His Glu Asp 
    290                 295                 300                 


Val Pro Trp Cys Arg Gly Glu Gly His Lys Pro Ser Ile Ala His Arg 
305                 310                 315                 320 


Asp Phe Lys Ser Lys Asn Val Leu Leu Lys Ser Asp Leu Thr Ala Val 
                325                 330                 335     


Leu Ala Asp Phe Gly Leu Ala Val Arg Phe Glu Pro Gly Lys Pro Pro 
            340                 345                 350         


Gly Asp Thr His Gly Gln Val Gly Thr Arg Arg Tyr Met Ala Pro Glu 
        355                 360                 365             


Val Leu Glu Gly Ala Ile Asn Phe Gln Arg Asp Ala Phe Leu Arg Ile 
    370                 375                 380                 


Asp Met Tyr Ala Met Gly Leu Val Leu Trp Glu Leu Val Ser Arg Cys 
385                 390                 395                 400 


Lys Ala Ala Asp Gly Pro Val Asp Glu Tyr Met Leu Pro Phe Glu Glu 
                405                 410                 415     


Glu Ile Gly Gln His Pro Ser Leu Glu Glu Leu Gln Glu Val Val Val 
            420                 425                 430         


His Lys Lys Met Arg Pro Thr Ile Lys Asp His Trp Leu Lys His Pro 
        435                 440                 445             


Gly Leu Ala Gln Leu Cys Val Thr Ile Glu Glu Cys Trp Asp His Asp 
    450                 455                 460                 


Ala Glu Ala Arg Leu Ser Ala Gly Cys Val Glu Glu Arg Val Ser Leu 
465                 470                 475                 480 


Ile Arg Arg Ser Val Asn Gly Thr Thr Ser Asp Cys Leu Val Ser Leu 
                485                 490                 495     


Val Thr Ser Val Thr Asn Val Asp Leu Pro Pro Lys Glu Ser Ser Ile 
            500                 505                 510         


<210>  46
<211>  116
<212>  PRT
<213>  Homo sapiens

<400>  46

Ser Gly Arg Gly Glu Ala Glu Thr Arg Glu Cys Ile Tyr Tyr Asn Ala 
1               5                   10                  15      


Asn Trp Glu Leu Glu Arg Thr Asn Gln Ser Gly Leu Glu Arg Cys Glu 
            20                  25                  30          


Gly Glu Gln Asp Lys Arg Leu His Cys Tyr Ala Ser Trp Arg Asn Ser 
        35                  40                  45              


Ser Gly Thr Ile Glu Leu Val Lys Lys Gly Cys Trp Leu Asp Asp Phe 
    50                  55                  60                  


Asn Cys Tyr Asp Arg Gln Glu Cys Val Ala Thr Glu Glu Asn Pro Gln 
65                  70                  75                  80  


Val Tyr Phe Cys Cys Cys Glu Gly Asn Phe Cys Asn Glu Arg Phe Thr 
                85                  90                  95      


His Leu Pro Glu Ala Gly Gly Pro Glu Val Thr Tyr Glu Pro Pro Pro 
            100                 105                 110         


Thr Ala Pro Thr 
        115     


<210>  47
<211>  513
<212>  PRT
<213>  Homo sapiens

<400>  47

Met Gly Ala Ala Thr Lys Leu Ala Phe Ala Val Phe Leu Ile Ser Cys 
1               5                   10                  15      


Ser Ser Gly Ala Ile Leu Gly Arg Ser Glu Thr Gln Glu Cys Ile Tyr 
            20                  25                  30          


Tyr Asn Ala Asn Trp Glu Lys Asp Lys Thr Asn Arg Ser Gly Ile Glu 
        35                  40                  45              


Pro Cys Tyr Gly Asp Lys Asp Lys Arg Arg His Cys Phe Ala Thr Trp 
    50                  55                  60                  


Lys Asn Ile Ser Gly Ser Ile Glu Ile Val Lys Gln Gly Cys Trp Leu 
65                  70                  75                  80  


Asp Asp Ile Asn Cys Tyr Asp Arg Asn Asp Cys Ile Glu Lys Lys Asp 
                85                  90                  95      


Ser Pro Glu Val Phe Phe Cys Cys Cys Glu Gly Asn Met Cys Asn Glu 
            100                 105                 110         


Arg Phe Phe Tyr Phe Pro Glu Met Glu Val Thr Gln Pro Thr Ser Asn 
        115                 120                 125             


Pro Val Thr Pro Lys Pro Pro Leu Phe Asn Thr Leu Leu Tyr Ser Leu 
    130                 135                 140                 


Val Pro Ile Met Gly Ile Ala Val Ile Val Leu Phe Ser Phe Trp Met 
145                 150                 155                 160 


Tyr Arg His His Lys Leu Ala Tyr Pro Pro Val Leu Val Pro Thr Gln 
                165                 170                 175     


Asp Pro Gly Pro Pro Pro Pro Ser Pro Leu Met Gly Leu Lys Pro Leu 
            180                 185                 190         


Gln Leu Leu Glu Ile Lys Ala Arg Gly Arg Phe Gly Cys Val Trp Lys 
        195                 200                 205             


Ala Gln Leu Leu Asn Glu Tyr Val Ala Val Lys Ile Phe Pro Ile Gln 
    210                 215                 220                 


Asp Lys Gln Ser Trp Gln Asn Glu Tyr Glu Ile Tyr Ser Leu Pro Gly 
225                 230                 235                 240 


Met Lys His Asp Asn Ile Leu Gln Phe Ile Gly Ala Glu Lys Arg Gly 
                245                 250                 255     


Thr Ser Ile Asp Val Asp Leu Trp Leu Ile Thr Ala Phe His Glu Lys 
            260                 265                 270         


Gly Ser Leu Thr Asp Phe Leu Lys Ala Asn Val Val Ser Trp Asn Glu 
        275                 280                 285             


Leu Cys His Ile Ala Gln Thr Met Ala Arg Gly Leu Ala Tyr Leu His 
    290                 295                 300                 


Glu Asp Ile Pro Gly Leu Lys Asp Gly His Lys Pro Ala Ile Ser His 
305                 310                 315                 320 


Arg Asp Ile Lys Ser Lys Asn Val Leu Leu Lys Asn Asn Leu Thr Ala 
                325                 330                 335     


Cys Ile Ala Asp Phe Gly Leu Ala Leu Lys Phe Glu Ala Gly Lys Ser 
            340                 345                 350         


Ala Gly Asp Thr His Gly Gln Val Gly Thr Arg Arg Tyr Met Ala Pro 
        355                 360                 365             


Glu Val Leu Glu Gly Ala Ile Asn Phe Gln Arg Asp Ala Phe Leu Arg 
    370                 375                 380                 


Ile Asp Met Tyr Ala Met Gly Leu Val Leu Trp Glu Leu Ala Ser Arg 
385                 390                 395                 400 


Cys Thr Ala Ser Asp Gly Pro Val Asp Glu Tyr Met Leu Pro Phe Glu 
                405                 410                 415     


Glu Glu Ile Gly Gln His Pro Ser Leu Glu Asp Met Gln Glu Val Val 
            420                 425                 430         


Val His Lys Lys Lys Arg Pro Val Leu Arg Glu Cys Trp Gln Lys His 
        435                 440                 445             


Ser Gly Met Ala Met Leu Cys Glu Thr Ile Glu Glu Cys Trp Asp His 
    450                 455                 460                 


Asp Ala Glu Ala Arg Leu Ser Ala Gly Cys Val Glu Glu Arg Ile Ile 
465                 470                 475                 480 


Gln Met Gln Lys Leu Thr Asn Ile Ile Thr Thr Glu Asp Ile Val Thr 
                485                 490                 495     


Val Val Thr Met Val Thr Asn Val Asp Phe Pro Pro Lys Glu Ser Ser 
            500                 505                 510         


Leu 
    


<210>  48
<211>  116
<212>  PRT
<213>  Homo sapiens

<400>  48

Ala Ile Leu Gly Arg Ser Glu Thr Gln Glu Cys Leu Phe Phe Asn Ala 
1               5                   10                  15      


Asn Trp Glu Lys Asp Arg Thr Asn Gln Thr Gly Val Glu Pro Cys Tyr 
            20                  25                  30          


Gly Asp Lys Asp Lys Arg Arg His Cys Phe Ala Thr Trp Lys Asn Ile 
        35                  40                  45              


Ser Gly Ser Ile Glu Ile Val Lys Gln Gly Cys Trp Leu Asp Asp Ile 
    50                  55                  60                  


Asn Cys Tyr Asp Arg Thr Asp Cys Val Glu Lys Lys Asp Ser Pro Glu 
65                  70                  75                  80  


Val Tyr Phe Cys Cys Cys Glu Gly Asn Met Cys Asn Glu Lys Phe Ser 
                85                  90                  95      


Tyr Phe Pro Glu Met Glu Val Thr Gln Pro Thr Ser Asn Pro Val Thr 
            100                 105                 110         


Pro Lys Pro Pro 
        115     


<210>  49
<211>  18
<212>  PRT
<213>  Artificial

<220>
<223>  ActRIIB signal peptide

<400>  49

Met Thr Ala Pro Trp Val Ala Leu Ala Leu Leu Trp Gly Ser Leu Cys 
1               5                   10                  15      


Ala Gly 
        


<210>  50
<211>  22
<212>  PRT
<213>  Artificial

<220>
<223>  Immunoglobulin light chain signal peptide

<400>  50

Met Asp Met Arg Val Pro Ala Gln Leu Leu Gly Leu Leu Leu Leu Trp 
1               5                   10                  15      


Leu Arg Gly Ala Arg Cys 
            20          


<210>  51
<211>  110
<212>  PRT
<213>  Artificial

<220>
<223>  Hybrid Human ActRIIB ECD

<400>  51

Glu Thr Gln Glu Cys Leu Phe Phe Asn Ala Asn Trp Glu Lys Asp Arg 
1               5                   10                  15      


Thr Asn Gln Ser Gly Val Glu Pro Cys Tyr Gly Asp Lys Asp Lys Arg 
            20                  25                  30          


Arg His Cys Tyr Ala Ser Trp Arg Asn Ser Ser Gly Thr Ile Glu Leu 
        35                  40                  45              


Val Lys Lys Gly Cys Trp Leu Asp Asp Phe Asn Cys Tyr Asp Arg Gln 
    50                  55                  60                  


Glu Cys Val Ala Thr Glu Glu Asn Pro Gln Val Tyr Phe Cys Cys Cys 
65                  70                  75                  80  


Glu Gly Asn Phe Cys Asn Glu Arg Phe Thr His Leu Pro Glu Ala Gly 
                85                  90                  95      


Gly Pro Glu Val Thr Tyr Glu Pro Pro Pro Thr Ala Pro Thr 
            100                 105                 110 


<210>  52
<211>  110
<212>  PRT
<213>  Artificial

<220>
<223>  Hybrid Human ActRIIB ECD

<400>  52

Glu Thr Gln Glu Cys Leu Phe Phe Asn Ala Asn Trp Glu Lys Asp Arg 
1               5                   10                  15      


Thr Asn Gln Ser Gly Val Glu Pro Cys Glu Gly Glu Gln Asp Lys Arg 
            20                  25                  30          


Leu His Cys Tyr Ala Ser Trp Arg Asn Ser Ser Gly Thr Ile Glu Leu 
        35                  40                  45              


Val Lys Lys Gly Cys Trp Leu Asp Asp Phe Asn Cys Tyr Asp Arg Gln 
    50                  55                  60                  


Glu Cys Val Ala Thr Glu Glu Asn Pro Gln Val Tyr Phe Cys Cys Cys 
65                  70                  75                  80  


Glu Gly Asn Phe Cys Asn Glu Arg Phe Thr His Leu Pro Glu Ala Gly 
                85                  90                  95      


Gly Pro Glu Val Thr Tyr Glu Pro Pro Pro Thr Ala Pro Thr 
            100                 105                 110 


<210>  53
<211>  110
<212>  PRT
<213>  Artificial

<220>
<223>  Hybrid Human ActRIIB ECD

<400>  53

Glu Thr Arg Glu Cys Leu Phe Phe Asn Ala Asn Trp Glu Lys Asp Arg 
1               5                   10                  15      


Thr Asn Gln Ser Gly Val Glu Pro Cys Glu Gly Glu Gln Asp Lys Arg 
            20                  25                  30          


Leu His Cys Tyr Ala Ser Trp Arg Asn Ser Ser Gly Thr Ile Glu Leu 
        35                  40                  45              


Val Lys Lys Gly Cys Trp Leu Asp Asp Phe Asn Cys Tyr Asp Arg Gln 
    50                  55                  60                  


Glu Cys Val Ala Thr Glu Glu Asn Pro Gln Val Tyr Phe Cys Cys Cys 
65                  70                  75                  80  


Glu Gly Asn Phe Cys Asn Glu Arg Phe Thr His Leu Pro Glu Ala Gly 
                85                  90                  95      


Gly Pro Glu Val Thr Tyr Glu Pro Pro Pro Thr Ala Pro Thr 
            100                 105                 110 


<210>  54
<211>  110
<212>  PRT
<213>  Artificial

<220>
<223>  Hybrid Human ActRIIB ECD

<400>  54

Glu Thr Gln Glu Cys Leu Phe Phe Asn Ala Asn Trp Glu Lys Asp Arg 
1               5                   10                  15      


Thr Asn Gln Ser Gly Val Glu Pro Cys Tyr Gly Glu Gln Asp Lys Arg 
            20                  25                  30          


Leu His Cys Tyr Ala Ser Trp Arg Asn Ser Ser Gly Thr Ile Glu Leu 
        35                  40                  45              


Val Lys Lys Gly Cys Trp Leu Asp Asp Phe Asn Cys Tyr Asp Arg Gln 
    50                  55                  60                  


Glu Cys Val Ala Thr Glu Glu Asn Pro Gln Val Tyr Phe Cys Cys Cys 
65                  70                  75                  80  


Glu Gly Asn Phe Cys Asn Glu Arg Phe Thr His Leu Pro Glu Ala Gly 
                85                  90                  95      


Gly Pro Glu Val Thr Tyr Glu Pro Pro Pro Thr Ala Pro Thr 
            100                 105                 110 


<210>  55
<211>  110
<212>  PRT
<213>  Artificial

<220>
<223>  Hybrid Human ActRIIB ECD

<400>  55

Glu Thr Arg Glu Cys Leu Phe Phe Asn Ala Asn Trp Glu Lys Asp Arg 
1               5                   10                  15      


Thr Asn Gln Ser Gly Val Glu Pro Cys Tyr Gly Asp Lys Asp Lys Arg 
            20                  25                  30          


Arg His Cys Tyr Ala Ser Trp Arg Asn Ser Ser Gly Thr Ile Glu Leu 
        35                  40                  45              


Val Lys Lys Gly Cys Trp Leu Asp Asp Phe Asn Cys Tyr Asp Arg Gln 
    50                  55                  60                  


Glu Cys Val Ala Thr Glu Glu Asn Pro Gln Val Tyr Phe Cys Cys Cys 
65                  70                  75                  80  


Glu Gly Asn Phe Cys Asn Glu Arg Phe Thr His Leu Pro Glu Ala Gly 
                85                  90                  95      


Gly Pro Glu Val Thr Tyr Glu Pro Pro Pro Thr Ala Pro Thr 
            100                 105                 110 


<210>  56
<211>  110
<212>  PRT
<213>  Artificial

<220>
<223>  Hybrid Human ActRIIB ECD

<400>  56

Glu Thr Arg Glu Cys Leu Phe Phe Asn Ala Asn Trp Glu Lys Asp Arg 
1               5                   10                  15      


Thr Asn Gln Thr Gly Val Glu Pro Cys Tyr Gly Asp Lys Asp Lys Arg 
            20                  25                  30          


Arg His Cys Phe Ala Thr Trp Lys Asn Ile Ser Gly Ser Ile Glu Ile 
        35                  40                  45              


Val Lys Gln Gly Cys Trp Leu Asp Asp Phe Asn Cys Tyr Asp Arg Gln 
    50                  55                  60                  


Glu Cys Val Ala Thr Glu Glu Asn Pro Gln Val Tyr Phe Cys Cys Cys 
65                  70                  75                  80  


Glu Gly Asn Phe Cys Asn Glu Arg Phe Thr His Leu Pro Glu Ala Gly 
                85                  90                  95      


Gly Pro Glu Val Thr Tyr Glu Pro Pro Pro Thr Ala Pro Thr 
            100                 105                 110 


<210>  57
<211>  110
<212>  PRT
<213>  Artificial

<220>
<223>  Hybrid Human ActRIIB ECD

<400>  57

Glu Thr Arg Glu Cys Leu Phe Phe Asn Ala Asn Trp Glu Lys Asp Arg 
1               5                   10                  15      


Thr Asn Gln Thr Gly Val Glu Pro Cys Tyr Gly Asp Lys Asp Lys Arg 
            20                  25                  30          


Arg His Cys Phe Ala Thr Trp Lys Asn Ile Ser Gly Ser Ile Glu Ile 
        35                  40                  45              


Val Lys Gln Gly Cys Trp Leu Asp Asp Ile Asn Cys Tyr Asp Arg Gln 
    50                  55                  60                  


Glu Cys Val Ala Thr Glu Glu Asn Pro Gln Val Tyr Phe Cys Cys Cys 
65                  70                  75                  80  


Glu Gly Asn Phe Cys Asn Glu Arg Phe Thr His Leu Pro Glu Ala Gly 
                85                  90                  95      


Gly Pro Glu Val Thr Tyr Glu Pro Pro Pro Thr Ala Pro Thr 
            100                 105                 110 


<210>  58
<211>  110
<212>  PRT
<213>  Artificial

<220>
<223>  Hybrid Human ActRIIB ECD

<400>  58

Glu Thr Arg Glu Cys Leu Phe Phe Asn Ala Asn Trp Glu Lys Asp Arg 
1               5                   10                  15      


Thr Asn Gln Thr Gly Val Glu Pro Cys Tyr Gly Asp Lys Asp Lys Arg 
            20                  25                  30          


Arg His Cys Phe Ala Thr Trp Lys Asn Ile Ser Gly Ser Ile Glu Ile 
        35                  40                  45              


Val Lys Gln Gly Cys Trp Leu Asp Asp Ile Asn Cys Tyr Asp Arg Thr 
    50                  55                  60                  


Asp Cys Val Glu Lys Lys Asp Ser Pro Glu Val Tyr Phe Cys Cys Cys 
65                  70                  75                  80  


Glu Gly Asn Phe Cys Asn Glu Arg Phe Thr His Leu Pro Glu Ala Gly 
                85                  90                  95      


Gly Pro Glu Val Thr Tyr Glu Pro Pro Pro Thr Ala Pro Thr 
            100                 105                 110 


<210>  59
<211>  110
<212>  PRT
<213>  Artificial

<220>
<223>  Hybrid Human ActRIIB ECD

<400>  59

Glu Thr Gln Glu Cys Ile Tyr Tyr Asn Ala Asn Trp Glu Leu Glu Arg 
1               5                   10                  15      


Thr Asn Gln Ser Gly Leu Glu Arg Cys Tyr Gly Asp Lys Asp Lys Arg 
            20                  25                  30          


Arg His Cys Phe Ala Thr Trp Lys Asn Ile Ser Gly Ser Ile Glu Ile 
        35                  40                  45              


Val Lys Gln Gly Cys Trp Leu Asp Asp Ile Asn Cys Tyr Asp Arg Gln 
    50                  55                  60                  


Glu Cys Val Ala Thr Glu Glu Asn Pro Gln Val Tyr Phe Cys Cys Cys 
65                  70                  75                  80  


Glu Gly Asn Phe Cys Asn Glu Arg Phe Thr His Leu Pro Glu Ala Gly 
                85                  90                  95      


Gly Pro Glu Val Thr Tyr Glu Pro Pro Pro Thr Ala Pro Thr 
            100                 105                 110 


<210>  60
<211>  110
<212>  PRT
<213>  Artificial

<220>
<223>  Hybrid Human ActRIIB ECD

<400>  60

Glu Thr Arg Glu Cys Ile Tyr Tyr Asn Ala Asn Trp Glu Leu Glu Arg 
1               5                   10                  15      


Thr Asn Gln Ser Gly Leu Glu Arg Cys Tyr Gly Asp Lys Asp Lys Arg 
            20                  25                  30          


Arg His Cys Phe Ala Thr Trp Lys Asn Ile Ser Gly Ser Ile Glu Ile 
        35                  40                  45              


Val Lys Gln Gly Cys Trp Leu Asp Asp Ile Asn Cys Tyr Asp Arg Thr 
    50                  55                  60                  


Asp Cys Val Glu Lys Lys Asp Ser Pro Glu Val Tyr Phe Cys Cys Cys 
65                  70                  75                  80  


Glu Gly Asn Phe Cys Asn Glu Arg Phe Thr His Leu Pro Glu Ala Gly 
                85                  90                  95      


Gly Pro Glu Val Thr Tyr Glu Pro Pro Pro Thr Ala Pro Thr 
            100                 105                 110 


<210>  61
<211>  110
<212>  PRT
<213>  Artificial

<220>
<223>  Hybrid Human ActRIIB ECD

<400>  61

Glu Thr Arg Glu Cys Ile Tyr Tyr Asn Ala Asn Trp Glu Leu Glu Arg 
1               5                   10                  15      


Thr Asn Gln Ser Gly Leu Glu Arg Cys Tyr Gly Asp Lys Asp Lys Arg 
            20                  25                  30          


Arg His Cys Phe Ala Thr Trp Lys Asn Ile Ser Gly Ser Ile Glu Ile 
        35                  40                  45              


Val Lys Gln Gly Cys Trp Leu Asp Asp Ile Asn Cys Tyr Asp Arg Thr 
    50                  55                  60                  


Asp Cys Val Glu Lys Lys Asp Ser Pro Glu Val Tyr Phe Cys Cys Cys 
65                  70                  75                  80  


Glu Gly Asn Met Cys Asn Glu Arg Phe Thr His Leu Pro Glu Ala Gly 
                85                  90                  95      


Gly Pro Glu Val Thr Tyr Glu Pro Pro Pro Thr Ala Pro Thr 
            100                 105                 110 


<210>  62
<211>  110
<212>  PRT
<213>  Artificial

<220>
<223>  Hybrid Human ActRIIB ECD

<400>  62

Glu Thr Arg Glu Cys Ile Tyr Tyr Asn Ala Asn Trp Glu Leu Glu Arg 
1               5                   10                  15      


Thr Asn Gln Ser Gly Leu Glu Arg Cys Glu Gly Glu Gln Asp Lys Arg 
            20                  25                  30          


Leu His Cys Phe Ala Thr Trp Lys Asn Ile Ser Gly Ser Ile Glu Ile 
        35                  40                  45              


Val Lys Gln Gly Cys Trp Leu Asp Asp Ile Asn Cys Tyr Asp Arg Thr 
    50                  55                  60                  


Asp Cys Val Glu Lys Lys Asp Ser Pro Glu Val Tyr Phe Cys Cys Cys 
65                  70                  75                  80  


Glu Gly Asn Phe Cys Asn Glu Arg Phe Thr His Leu Pro Glu Ala Gly 
                85                  90                  95      


Gly Pro Glu Val Thr Tyr Glu Pro Pro Pro Thr Ala Pro Thr 
            100                 105                 110 


<210>  63
<211>  110
<212>  PRT
<213>  Artificial

<220>
<223>  Hybrid Human ActRIIB ECD

<400>  63

Glu Thr Arg Glu Cys Ile Tyr Tyr Asn Ala Asn Trp Glu Leu Glu Arg 
1               5                   10                  15      


Thr Asn Gln Ser Gly Leu Glu Arg Cys Glu Gly Glu Gln Asp Lys Arg 
            20                  25                  30          


Leu His Cys Phe Ala Thr Trp Lys Asn Ile Ser Gly Ser Ile Glu Ile 
        35                  40                  45              


Val Lys Gln Gly Cys Trp Leu Asp Asp Ile Asn Cys Tyr Asp Arg Thr 
    50                  55                  60                  


Asp Cys Val Ala Thr Glu Glu Asn Pro Gln Val Tyr Phe Cys Cys Cys 
65                  70                  75                  80  


Glu Gly Asn Phe Cys Asn Glu Arg Phe Thr His Leu Pro Glu Ala Gly 
                85                  90                  95      


Gly Pro Glu Val Thr Tyr Glu Pro Pro Pro Thr Ala Pro Thr 
            100                 105                 110 


<210>  64
<211>  110
<212>  PRT
<213>  Artificial

<220>
<223>  Hybrid Human ActRIIB ECD

<400>  64

Glu Thr Arg Glu Cys Ile Tyr Tyr Asn Ala Asn Trp Glu Leu Glu Arg 
1               5                   10                  15      


Thr Asn Gln Ser Gly Leu Glu Arg Cys Glu Gly Glu Gln Asp Lys Arg 
            20                  25                  30          


Leu His Cys Phe Ala Thr Trp Lys Asn Ile Ser Gly Ser Ile Glu Ile 
        35                  40                  45              


Val Lys Gln Gly Cys Trp Leu Asp Asp Phe Asn Cys Tyr Asp Arg Thr 
    50                  55                  60                  


Asp Cys Val Ala Thr Glu Glu Asn Pro Gln Val Tyr Phe Cys Cys Cys 
65                  70                  75                  80  


Glu Gly Asn Phe Cys Asn Glu Arg Phe Thr His Leu Pro Glu Ala Gly 
                85                  90                  95      


Gly Pro Glu Val Thr Tyr Glu Pro Pro Pro Thr Ala Pro Thr 
            100                 105                 110 


<210>  65
<211>  110
<212>  PRT
<213>  Artificial

<220>
<223>  Hybrid Human ActRIIB ECD

<400>  65

Glu Thr Arg Glu Cys Ile Tyr Tyr Asn Ala Asn Trp Glu Leu Glu Arg 
1               5                   10                  15      


Thr Asn Gln Ser Gly Leu Glu Arg Cys Glu Gly Glu Gln Asp Lys Arg 
            20                  25                  30          


Leu His Cys Phe Ala Thr Trp Lys Asn Ile Ser Gly Ser Ile Glu Ile 
        35                  40                  45              


Val Lys Gln Gly Cys Trp Leu Asp Asp Phe Asn Cys Tyr Asp Arg Gln 
    50                  55                  60                  


Glu Cys Val Ala Thr Glu Glu Asn Pro Gln Val Tyr Phe Cys Cys Cys 
65                  70                  75                  80  


Glu Gly Asn Phe Cys Asn Glu Arg Phe Thr His Leu Pro Glu Ala Gly 
                85                  90                  95      


Gly Pro Glu Val Thr Tyr Glu Pro Pro Pro Thr Ala Pro Thr 
            100                 105                 110 


<210>  66
<211>  110
<212>  PRT
<213>  Artificial

<220>
<223>  Hybrid Human ActRIIB ECD

<400>  66

Glu Thr Gln Glu Cys Ile Tyr Tyr Asn Ala Asn Trp Glu Leu Glu Arg 
1               5                   10                  15      


Thr Asn Gln Ser Gly Leu Glu Arg Cys Tyr Gly Asp Lys Asp Lys Arg 
            20                  25                  30          


Arg His Cys Tyr Ala Ser Trp Arg Asn Ser Ser Gly Thr Ile Glu Leu 
        35                  40                  45              


Val Lys Lys Gly Cys Trp Leu Asp Asp Ile Asn Cys Tyr Asp Arg Thr 
    50                  55                  60                  


Asp Cys Val Glu Lys Lys Asp Ser Pro Glu Val Tyr Phe Cys Cys Cys 
65                  70                  75                  80  


Glu Gly Asn Phe Cys Asn Glu Arg Phe Thr His Leu Pro Glu Ala Gly 
                85                  90                  95      


Gly Pro Glu Val Thr Tyr Glu Pro Pro Pro Thr Ala Pro Thr 
            100                 105                 110 


<210>  67
<211>  110
<212>  PRT
<213>  Artificial

<220>
<223>  Hybrid Human ActRIIB ECD

<400>  67

Glu Thr Gln Glu Cys Ile Tyr Tyr Asn Ala Asn Trp Glu Leu Glu Arg 
1               5                   10                  15      


Thr Asn Gln Ser Gly Leu Glu Arg Cys Tyr Gly Asp Lys Asp Lys Arg 
            20                  25                  30          


Arg His Cys Tyr Ala Ser Trp Arg Asn Ser Ser Gly Thr Ile Glu Leu 
        35                  40                  45              


Val Lys Lys Gly Cys Trp Leu Asp Asp Ile Asn Cys Tyr Asp Arg Thr 
    50                  55                  60                  


Asp Cys Val Glu Lys Lys Asp Ser Pro Glu Val Tyr Phe Cys Cys Cys 
65                  70                  75                  80  


Glu Gly Asn Met Cys Asn Glu Arg Phe Thr His Leu Pro Glu Ala Gly 
                85                  90                  95      


Gly Pro Glu Val Thr Tyr Glu Pro Pro Pro Thr Ala Pro Thr 
            100                 105                 110 


<210>  68
<211>  110
<212>  PRT
<213>  Artificial

<220>
<223>  Hybrid Human ActRIIB ECD

<400>  68

Glu Thr Gln Glu Cys Ile Tyr Tyr Asn Ala Asn Trp Glu Leu Glu Arg 
1               5                   10                  15      


Thr Asn Gln Ser Gly Leu Glu Arg Cys Tyr Gly Asp Lys Asp Lys Arg 
            20                  25                  30          


Arg His Cys Phe Ala Thr Trp Lys Asn Ile Ser Gly Ser Ile Glu Ile 
        35                  40                  45              


Val Lys Gln Gly Cys Trp Leu Asp Asp Ile Asn Cys Tyr Asp Arg Thr 
    50                  55                  60                  


Asp Cys Val Glu Lys Lys Asp Ser Pro Glu Val Tyr Phe Cys Cys Cys 
65                  70                  75                  80  


Glu Gly Asn Met Cys Asn Glu Arg Phe Thr His Leu Pro Glu Ala Gly 
                85                  90                  95      


Gly Pro Glu Val Thr Tyr Glu Pro Pro Pro Thr Ala Pro Thr 
            100                 105                 110 


<210>  69
<211>  110
<212>  PRT
<213>  Artificial

<220>
<223>  Hybrid Human ActRIIB ECD

<400>  69

Glu Thr Gln Glu Cys Ile Tyr Tyr Asn Ala Asn Trp Glu Leu Glu Arg 
1               5                   10                  15      


Thr Asn Gln Ser Gly Leu Glu Arg Cys Tyr Gly Asp Lys Asp Lys Arg 
            20                  25                  30          


Arg His Cys Phe Ala Thr Trp Lys Asn Ile Ser Gly Ser Ile Glu Ile 
        35                  40                  45              


Val Lys Gln Gly Cys Trp Leu Asp Asp Ile Asn Cys Tyr Asp Arg Thr 
    50                  55                  60                  


Asp Cys Val Glu Lys Lys Asp Ser Pro Glu Val Tyr Phe Cys Cys Cys 
65                  70                  75                  80  


Glu Gly Asn Phe Cys Asn Glu Arg Phe Thr His Leu Pro Glu Ala Gly 
                85                  90                  95      


Gly Pro Glu Val Thr Tyr Glu Pro Pro Pro Thr Ala Pro Thr 
            100                 105                 110 


<210>  70
<211>  110
<212>  PRT
<213>  Artificial

<220>
<223>  Hybrid Human ActRIIB ECD

<400>  70

Glu Thr Arg Glu Cys Leu Phe Phe Asn Ala Asn Trp Glu Lys Asp Arg 
1               5                   10                  15      


Thr Asn Gln Thr Gly Val Glu Pro Cys Glu Gly Glu Gln Asp Lys Arg 
            20                  25                  30          


Leu His Cys Phe Ala Thr Trp Lys Asn Ile Ser Gly Ser Ile Glu Ile 
        35                  40                  45              


Val Lys Gln Gly Cys Trp Leu Asp Asp Ile Asn Cys Tyr Asp Arg Thr 
    50                  55                  60                  


Asp Cys Val Glu Lys Lys Asp Ser Pro Glu Val Tyr Phe Cys Cys Cys 
65                  70                  75                  80  


Glu Gly Asn Phe Cys Asn Glu Arg Phe Thr His Leu Pro Glu Ala Gly 
                85                  90                  95      


Gly Pro Glu Val Thr Tyr Glu Pro Pro Pro Thr Ala Pro Thr 
            100                 105                 110 


<210>  71
<211>  110
<212>  PRT
<213>  Artificial

<220>
<223>  Hybrid Human ActRIIB ECD

<400>  71

Glu Thr Arg Glu Cys Leu Phe Phe Asn Ala Asn Trp Glu Lys Asp Arg 
1               5                   10                  15      


Thr Asn Gln Ser Gly Val Glu Pro Cys Glu Gly Glu Gln Asp Lys Arg 
            20                  25                  30          


Leu His Cys Tyr Ala Ser Trp Arg Asn Ser Ser Gly Thr Ile Glu Leu 
        35                  40                  45              


Val Lys Lys Gly Cys Trp Leu Asp Asp Ile Asn Cys Tyr Asp Arg Thr 
    50                  55                  60                  


Asp Cys Val Glu Lys Lys Asp Ser Pro Glu Val Tyr Phe Cys Cys Cys 
65                  70                  75                  80  


Glu Gly Asn Phe Cys Asn Glu Arg Phe Thr His Leu Pro Glu Ala Gly 
                85                  90                  95      


Gly Pro Glu Val Thr Tyr Glu Pro Pro Pro Thr Ala Pro Thr 
            100                 105                 110 


<210>  72
<211>  110
<212>  PRT
<213>  Artificial

<220>
<223>  Hybrid Human ActRIIB ECD

<400>  72

Glu Thr Arg Glu Cys Leu Phe Phe Asn Ala Asn Trp Glu Lys Asp Arg 
1               5                   10                  15      


Thr Asn Gln Ser Gly Val Glu Pro Cys Tyr Gly Asp Lys Asp Lys Arg 
            20                  25                  30          


Arg His Cys Tyr Ala Ser Trp Arg Asn Ser Ser Gly Thr Ile Glu Leu 
        35                  40                  45              


Val Lys Lys Gly Cys Trp Leu Asp Asp Ile Asn Cys Tyr Asp Arg Thr 
    50                  55                  60                  


Asp Cys Val Glu Lys Lys Asp Ser Pro Glu Val Tyr Phe Cys Cys Cys 
65                  70                  75                  80  


Glu Gly Asn Phe Cys Asn Glu Arg Phe Thr His Leu Pro Glu Ala Gly 
                85                  90                  95      


Gly Pro Glu Val Thr Tyr Glu Pro Pro Pro Thr Ala Pro Thr 
            100                 105                 110 


<210>  73
<211>  110
<212>  PRT
<213>  Artificial

<220>
<223>  Hybrid Human ActRIIB ECD

<400>  73

Glu Thr Arg Glu Cys Ile Tyr Tyr Asn Ala Asn Trp Glu Leu Glu Arg 
1               5                   10                  15      


Thr Asn Gln Ser Gly Leu Glu Arg Cys Tyr Gly Asp Lys Asp Lys Arg 
            20                  25                  30          


Arg His Cys Tyr Ala Ser Trp Arg Asn Ser Ser Gly Thr Ile Glu Leu 
        35                  40                  45              


Val Lys Lys Gly Cys Trp Leu Asp Asp Phe Asn Cys Tyr Asp Arg Thr 
    50                  55                  60                  


Asp Cys Val Ala Thr Glu Glu Asn Pro Gln Val Tyr Phe Cys Cys Cys 
65                  70                  75                  80  


Glu Gly Asn Phe Cys Asn Glu Arg Phe Thr His Leu Pro Glu Ala Gly 
                85                  90                  95      


Gly Pro Glu Val Thr Tyr Glu Pro Pro Pro Thr Ala Pro Thr 
            100                 105                 110 


<210>  74
<211>  110
<212>  PRT
<213>  Artificial

<220>
<223>  Hybrid Human ActRIIB ECD

<400>  74

Glu Thr Arg Glu Cys Ile Tyr Tyr Asn Ala Asn Trp Glu Leu Glu Arg 
1               5                   10                  15      


Thr Asn Gln Ser Gly Leu Glu Arg Cys Tyr Gly Asp Lys Asp Lys Arg 
            20                  25                  30          


Arg His Cys Tyr Ala Ser Trp Arg Asn Ser Ser Gly Thr Ile Glu Leu 
        35                  40                  45              


Val Lys Gln Gly Cys Trp Leu Asp Asp Phe Asn Cys Tyr Asp Arg Thr 
    50                  55                  60                  


Asp Cys Val Ala Thr Glu Glu Asn Pro Gln Val Tyr Phe Cys Cys Cys 
65                  70                  75                  80  


Glu Gly Asn Phe Cys Asn Glu Arg Phe Thr His Leu Pro Glu Ala Gly 
                85                  90                  95      


Gly Pro Glu Val Thr Tyr Glu Pro Pro Pro Thr Ala Pro Thr 
            100                 105                 110 


<210>  75
<211>  110
<212>  PRT
<213>  Artificial

<220>
<223>  Hybrid Human ActRIIB ECD

<400>  75

Glu Thr Arg Glu Cys Ile Tyr Tyr Asn Ala Asn Trp Glu Leu Glu Arg 
1               5                   10                  15      


Thr Asn Gln Ser Gly Leu Glu Arg Cys Tyr Gly Asp Lys Asp Lys Arg 
            20                  25                  30          


Arg His Cys Tyr Ala Ser Trp Arg Asn Ser Ser Gly Thr Ile Glu Ile 
        35                  40                  45              


Val Lys Lys Gly Cys Trp Leu Asp Asp Phe Asn Cys Tyr Asp Arg Thr 
    50                  55                  60                  


Asp Cys Val Ala Thr Glu Glu Asn Pro Gln Val Tyr Phe Cys Cys Cys 
65                  70                  75                  80  


Glu Gly Asn Phe Cys Asn Glu Arg Phe Thr His Leu Pro Glu Ala Gly 
                85                  90                  95      


Gly Pro Glu Val Thr Tyr Glu Pro Pro Pro Thr Ala Pro Thr 
            100                 105                 110 


<210>  76
<211>  110
<212>  PRT
<213>  Artificial

<220>
<223>  Hybrid Human ActRIIB ECD

<400>  76

Glu Thr Arg Glu Cys Ile Tyr Tyr Asn Ala Asn Trp Glu Leu Glu Arg 
1               5                   10                  15      


Thr Asn Gln Ser Gly Leu Glu Arg Cys Tyr Gly Asp Lys Asp Lys Arg 
            20                  25                  30          


Arg His Cys Tyr Ala Ser Trp Arg Asn Ser Ser Gly Ser Ile Glu Leu 
        35                  40                  45              


Val Lys Lys Gly Cys Trp Leu Asp Asp Phe Asn Cys Tyr Asp Arg Thr 
    50                  55                  60                  


Asp Cys Val Ala Thr Glu Glu Asn Pro Gln Val Tyr Phe Cys Cys Cys 
65                  70                  75                  80  


Glu Gly Asn Phe Cys Asn Glu Arg Phe Thr His Leu Pro Glu Ala Gly 
                85                  90                  95      


Gly Pro Glu Val Thr Tyr Glu Pro Pro Pro Thr Ala Pro Thr 
            100                 105                 110 


<210>  77
<211>  110
<212>  PRT
<213>  Artificial

<220>
<223>  Hybrid Human ActRIIB ECD

<400>  77

Glu Thr Arg Glu Cys Ile Tyr Tyr Asn Ala Asn Trp Glu Leu Glu Arg 
1               5                   10                  15      


Thr Asn Gln Ser Gly Leu Glu Arg Cys Tyr Gly Asp Lys Asp Lys Arg 
            20                  25                  30          


Arg His Cys Tyr Ala Ser Trp Arg Asn Ser Ser Gly Ser Ile Glu Ile 
        35                  40                  45              


Val Lys Lys Gly Cys Trp Leu Asp Asp Phe Asn Cys Tyr Asp Arg Thr 
    50                  55                  60                  


Asp Cys Val Ala Thr Glu Glu Asn Pro Gln Val Tyr Phe Cys Cys Cys 
65                  70                  75                  80  


Glu Gly Asn Phe Cys Asn Glu Arg Phe Thr His Leu Pro Glu Ala Gly 
                85                  90                  95      


Gly Pro Glu Val Thr Tyr Glu Pro Pro Pro Thr Ala Pro Thr 
            100                 105                 110 


<210>  78
<211>  110
<212>  PRT
<213>  Artificial

<220>
<223>  Hybrid Human ActRIIB ECD

<400>  78

Glu Thr Arg Glu Cys Ile Tyr Tyr Asn Ala Asn Trp Glu Leu Glu Arg 
1               5                   10                  15      


Thr Asn Gln Ser Gly Leu Glu Arg Cys Tyr Gly Asp Lys Asp Lys Arg 
            20                  25                  30          


Arg His Cys Tyr Ala Ser Trp Arg Asn Ser Ser Gly Ser Ile Glu Ile 
        35                  40                  45              


Val Lys Gln Gly Cys Trp Leu Asp Asp Phe Asn Cys Tyr Asp Arg Thr 
    50                  55                  60                  


Asp Cys Val Ala Thr Glu Glu Asn Pro Gln Val Tyr Phe Cys Cys Cys 
65                  70                  75                  80  


Glu Gly Asn Phe Cys Asn Glu Arg Phe Thr His Leu Pro Glu Ala Gly 
                85                  90                  95      


Gly Pro Glu Val Thr Tyr Glu Pro Pro Pro Thr Ala Pro Thr 
            100                 105                 110 


<210>  79
<211>  110
<212>  PRT
<213>  Artificial

<220>
<223>  Hybrid Human ActRIIB ECD

<400>  79

Glu Thr Arg Glu Cys Ile Tyr Tyr Asn Ala Asn Trp Glu Leu Glu Arg 
1               5                   10                  15      


Thr Asn Gln Ser Gly Leu Glu Arg Cys Glu Gly Glu Gln Asp Lys Arg 
            20                  25                  30          


Leu His Cys Tyr Ala Ser Trp Arg Asn Ser Ser Gly Thr Ile Glu Leu 
        35                  40                  45              


Val Lys Lys Gly Cys Trp Leu Asp Asp Phe Asn Cys Tyr Asp Arg Thr 
    50                  55                  60                  


Asp Cys Val Ala Thr Glu Glu Asn Pro Gln Val Tyr Phe Cys Cys Cys 
65                  70                  75                  80  


Glu Gly Asn Phe Cys Asn Glu Arg Phe Thr His Leu Pro Glu Ala Gly 
                85                  90                  95      


Gly Pro Glu Val Thr Tyr Glu Pro Pro Pro Thr Ala Pro Thr 
            100                 105                 110 


<210>  80
<211>  110
<212>  PRT
<213>  Artificial

<220>
<223>  Hybrid Human ActRIIB ECD

<400>  80

Glu Thr Arg Glu Cys Ile Tyr Tyr Asn Ala Asn Trp Glu Leu Glu Arg 
1               5                   10                  15      


Thr Asn Gln Ser Gly Leu Glu Arg Cys Glu Gly Glu Gln Asp Lys Arg 
            20                  25                  30          


Leu His Cys Tyr Ala Ser Trp Arg Asn Ser Ser Gly Thr Ile Glu Leu 
        35                  40                  45              


Val Lys Lys Gly Cys Trp Leu Asp Asp Phe Asn Cys Tyr Asp Arg Gln 
    50                  55                  60                  


Glu Cys Val Ala Thr Glu Glu Asn Pro Gln Val Tyr Phe Cys Cys Cys 
65                  70                  75                  80  


Glu Gly Asn Phe Cys Asn Glu Lys Phe Ser Tyr Phe Pro Glu Met Glu 
                85                  90                  95      


Val Thr Gln Pro Thr Ser Asn Pro Val Thr Pro Lys Pro Pro 
            100                 105                 110 


<210>  81
<211>  110
<212>  PRT
<213>  Artificial

<220>
<223>  Hybrid Human ActRIIB ECD

<400>  81

Glu Thr Arg Glu Cys Ile Tyr Tyr Asn Ala Asn Trp Glu Leu Glu Arg 
1               5                   10                  15      


Thr Asn Gln Ser Gly Leu Glu Arg Cys Glu Gly Glu Gln Asp Lys Arg 
            20                  25                  30          


Leu His Cys Tyr Ala Ser Trp Arg Asn Ser Ser Gly Thr Ile Glu Leu 
        35                  40                  45              


Val Lys Lys Gly Cys Trp Leu Asp Asp Phe Asn Cys Tyr Asp Arg Gln 
    50                  55                  60                  


Glu Cys Val Ala Thr Glu Glu Asn Pro Gln Val Tyr Phe Cys Cys Cys 
65                  70                  75                  80  


Glu Gly Asn Phe Cys Asn Glu Lys Phe Ser Tyr Phe Pro Gln Met Glu 
                85                  90                  95      


Val Thr Gln Pro Thr Ser Asn Pro Val Thr Pro Lys Pro Pro 
            100                 105                 110 


<210>  82
<211>  110
<212>  PRT
<213>  Artificial

<220>
<223>  Hybrid Human ActRIIB ECD

<400>  82

Glu Thr Arg Glu Cys Ile Tyr Tyr Asn Ala Asn Trp Glu Leu Glu Arg 
1               5                   10                  15      


Thr Asn Gln Ser Gly Leu Glu Arg Cys Tyr Gly Asp Lys Asp Lys Arg 
            20                  25                  30          


Arg His Cys Tyr Ala Ser Trp Arg Asn Ser Ser Gly Thr Ile Glu Leu 
        35                  40                  45              


Val Lys Lys Gly Cys Trp Leu Asp Asp Ile Asn Cys Tyr Asp Arg Thr 
    50                  55                  60                  


Asp Cys Val Glu Lys Lys Asp Ser Pro Glu Val Tyr Phe Cys Cys Cys 
65                  70                  75                  80  


Glu Gly Asn Phe Cys Asn Glu Lys Phe Ser Tyr Phe Pro Glu Met Glu 
                85                  90                  95      


Val Thr Gln Pro Thr Ser Asn Pro Val Thr Pro Lys Pro Pro 
            100                 105                 110 


<210>  83
<211>  110
<212>  PRT
<213>  Artificial

<220>
<223>  Hybrid Human ActRIIB ECD

<400>  83

Glu Thr Arg Glu Cys Ile Tyr Tyr Asn Ala Asn Trp Glu Leu Glu Arg 
1               5                   10                  15      


Thr Asn Gln Ser Gly Leu Glu Arg Cys Tyr Gly Asp Lys Asp Lys Arg 
            20                  25                  30          


Arg His Cys Tyr Ala Ser Trp Arg Asn Ser Ser Gly Thr Ile Glu Leu 
        35                  40                  45              


Val Lys Lys Gly Cys Trp Leu Asp Asp Ile Asn Cys Tyr Asp Arg Thr 
    50                  55                  60                  


Asp Cys Val Glu Lys Lys Asp Ser Pro Glu Val Tyr Phe Cys Cys Cys 
65                  70                  75                  80  


Glu Gly Asn Phe Cys Asn Glu Lys Phe Ser Tyr Phe Pro Gln Met Glu 
                85                  90                  95      


Val Thr Gln Pro Thr Ser Asn Pro Val Thr Pro Lys Pro Pro 
            100                 105                 110 


<210>  84
<211>  110
<212>  PRT
<213>  Artificial

<220>
<223>  Hybrid Human ActRIIB ECD

<400>  84

Glu Thr Arg Glu Cys Ile Tyr Tyr Asn Ala Asn Trp Glu Leu Glu Arg 
1               5                   10                  15      


Thr Asn Gln Ser Gly Leu Glu Arg Cys Tyr Gly Asp Lys Asp Lys Arg 
            20                  25                  30          


Arg His Cys Tyr Ala Ser Trp Arg Asn Ser Ser Gly Thr Ile Glu Leu 
        35                  40                  45              


Val Lys Lys Gly Cys Trp Leu Asp Asp Phe Asn Cys Tyr Asp Arg Gln 
    50                  55                  60                  


Glu Cys Val Ala Thr Glu Glu Asn Pro Gln Val Tyr Phe Cys Cys Cys 
65                  70                  75                  80  


Glu Gly Asn Phe Cys Asn Glu Lys Phe Ser Tyr Phe Pro Gln Met Glu 
                85                  90                  95      


Val Thr Gln Pro Thr Ser Asn Pro Val Thr Pro Lys Pro Pro 
            100                 105                 110 


<210>  85
<211>  110
<212>  PRT
<213>  Artificial

<220>
<223>  Hybrid Human ActRIIB ECD

<400>  85

Glu Thr Arg Glu Cys Ile Tyr Tyr Asn Ala Asn Trp Glu Leu Glu Arg 
1               5                   10                  15      


Thr Asn Gln Ser Gly Leu Glu Arg Cys Tyr Gly Asp Lys Asp Lys Arg 
            20                  25                  30          


Arg His Cys Tyr Ala Ser Trp Arg Asn Ser Ser Gly Thr Ile Glu Leu 
        35                  40                  45              


Val Lys Gln Gly Cys Trp Leu Asp Asp Phe Asn Cys Tyr Asp Arg Gln 
    50                  55                  60                  


Glu Cys Val Ala Thr Glu Glu Asn Pro Gln Val Tyr Phe Cys Cys Cys 
65                  70                  75                  80  


Glu Gly Asn Phe Cys Asn Glu Lys Phe Ser Tyr Phe Pro Gln Met Glu 
                85                  90                  95      


Val Thr Gln Pro Thr Ser Asn Pro Val Thr Pro Lys Pro Pro 
            100                 105                 110 


<210>  86
<211>  110
<212>  PRT
<213>  Artificial

<220>
<223>  Hybrid Human ActRIIB ECD

<400>  86

Glu Thr Arg Glu Cys Ile Tyr Tyr Asn Ala Asn Trp Glu Leu Glu Arg 
1               5                   10                  15      


Thr Asn Gln Ser Gly Leu Glu Arg Cys Tyr Gly Asp Lys Asp Lys Arg 
            20                  25                  30          


Arg His Cys Tyr Ala Ser Trp Arg Asn Ser Ser Gly Thr Ile Glu Ile 
        35                  40                  45              


Val Lys Lys Gly Cys Trp Leu Asp Asp Phe Asn Cys Tyr Asp Arg Gln 
    50                  55                  60                  


Glu Cys Val Ala Thr Lys Glu Asn Pro Gln Val Tyr Phe Cys Cys Cys 
65                  70                  75                  80  


Glu Gly Asn Phe Cys Asn Glu Lys Phe Ser Tyr Phe Pro Gln Met Glu 
                85                  90                  95      


Val Thr Gln Pro Thr Ser Asn Pro Val Thr Pro Lys Pro Pro 
            100                 105                 110 


<210>  87
<211>  110
<212>  PRT
<213>  Artificial

<220>
<223>  Hybrid Human ActRIIB ECD

<400>  87

Glu Thr Arg Glu Cys Ile Tyr Tyr Asn Ala Asn Trp Glu Leu Glu Arg 
1               5                   10                  15      


Thr Asn Gln Ser Gly Leu Glu Arg Cys Tyr Gly Asp Lys Asp Lys Arg 
            20                  25                  30          


Arg His Cys Tyr Ala Ser Trp Arg Asn Ser Ser Gly Ser Ile Glu Leu 
        35                  40                  45              


Val Lys Lys Gly Cys Trp Leu Asp Asp Phe Asn Cys Tyr Asp Arg Gln 
    50                  55                  60                  


Glu Cys Val Ala Thr Lys Glu Asn Pro Gln Val Tyr Phe Cys Cys Cys 
65                  70                  75                  80  


Glu Gly Asn Phe Cys Asn Glu Lys Phe Ser Tyr Phe Pro Gln Met Glu 
                85                  90                  95      


Val Thr Gln Pro Thr Ser Asn Pro Val Thr Pro Lys Pro Pro 
            100                 105                 110 


<210>  88
<211>  110
<212>  PRT
<213>  Artificial

<220>
<223>  Hybrid Human ActRIIB ECD

<400>  88

Glu Thr Arg Glu Cys Ile Tyr Tyr Asn Ala Asn Trp Glu Leu Glu Arg 
1               5                   10                  15      


Thr Asn Gln Ser Gly Leu Glu Arg Cys Glu Gly Glu Gln Asp Lys Arg 
            20                  25                  30          


Leu His Cys Tyr Ala Ser Trp Arg Asn Ser Ser Gly Ser Ile Glu Leu 
        35                  40                  45              


Val Lys Lys Gly Cys Trp Leu Asp Asp Phe Asn Cys Tyr Asp Arg Gln 
    50                  55                  60                  


Glu Cys Val Ala Thr Glu Glu Asn Pro Gln Val Tyr Phe Cys Cys Cys 
65                  70                  75                  80  


Glu Gly Asn Phe Cys Asn Glu Lys Phe Ser Tyr Phe Pro Gln Met Glu 
                85                  90                  95      


Val Thr Gln Pro Thr Ser Asn Pro Val Thr Pro Lys Pro Pro 
            100                 105                 110 


<210>  89
<211>  110
<212>  PRT
<213>  Artificial

<220>
<223>  Hybrid Human ActRIIB ECD

<400>  89

Glu Thr Arg Glu Cys Ile Tyr Tyr Asn Ala Asn Trp Glu Leu Glu Arg 
1               5                   10                  15      


Thr Asn Gln Ser Gly Leu Glu Arg Cys Glu Gly Glu Gln Asp Lys Arg 
            20                  25                  30          


Leu His Cys Tyr Ala Ser Trp Arg Asn Ser Ser Gly Thr Ile Glu Ile 
        35                  40                  45              


Val Lys Lys Gly Cys Trp Leu Asp Asp Phe Asn Cys Tyr Asp Arg Gln 
    50                  55                  60                  


Glu Cys Val Ala Thr Glu Glu Asn Pro Gln Val Tyr Phe Cys Cys Cys 
65                  70                  75                  80  


Glu Gly Asn Phe Cys Asn Glu Lys Phe Ser Tyr Phe Pro Gln Met Glu 
                85                  90                  95      


Val Thr Gln Pro Thr Ser Asn Pro Val Thr Pro Lys Pro Pro 
            100                 105                 110 


<210>  90
<211>  110
<212>  PRT
<213>  Artificial

<220>
<223>  Hybrid Human ActRIIB ECD

<400>  90

Glu Thr Arg Glu Cys Ile Tyr Tyr Asn Ala Asn Trp Glu Leu Glu Arg 
1               5                   10                  15      


Thr Asn Gln Ser Gly Leu Glu Arg Cys Glu Gly Glu Gln Asp Lys Arg 
            20                  25                  30          


Leu His Cys Tyr Ala Ser Trp Arg Asn Ser Ser Gly Thr Ile Glu Leu 
        35                  40                  45              


Val Lys Gln Gly Cys Trp Leu Asp Asp Phe Asn Cys Tyr Asp Arg Gln 
    50                  55                  60                  


Glu Cys Val Ala Thr Glu Glu Asn Pro Gln Val Tyr Phe Cys Cys Cys 
65                  70                  75                  80  


Glu Gly Asn Phe Cys Asn Glu Lys Phe Ser Tyr Phe Pro Gln Met Glu 
                85                  90                  95      


Val Thr Gln Pro Thr Ser Asn Pro Val Thr Pro Lys Pro Pro 
            100                 105                 110 


<210>  91
<211>  110
<212>  PRT
<213>  Artificial

<220>
<223>  Hybrid Human ActRIIB ECD

<400>  91

Glu Thr Arg Glu Cys Ile Tyr Tyr Asn Ala Asn Trp Glu Leu Glu Arg 
1               5                   10                  15      


Thr Asn Gln Ser Gly Leu Glu Arg Cys Glu Gly Glu Gln Asp Lys Arg 
            20                  25                  30          


Leu His Cys Tyr Ala Ser Trp Arg Asn Ser Ser Gly Thr Ile Glu Leu 
        35                  40                  45              


Val Lys Lys Gly Cys Trp Leu Asp Asp Phe Asn Cys Tyr Asp Arg Gln 
    50                  55                  60                  


Glu Cys Val Glu Thr Glu Glu Asn Pro Gln Val Tyr Phe Cys Cys Cys 
65                  70                  75                  80  


Glu Gly Asn Phe Cys Asn Glu Lys Phe Ser Tyr Phe Pro Gln Met Glu 
                85                  90                  95      


Val Thr Gln Pro Thr Ser Asn Pro Val Thr Pro Lys Pro Pro 
            100                 105                 110 


<210>  92
<211>  110
<212>  PRT
<213>  Artificial

<220>
<223>  Hybrid Human ActRIIB ECD

<400>  92

Glu Thr Arg Glu Cys Ile Tyr Tyr Asn Ala Asn Trp Glu Leu Glu Arg 
1               5                   10                  15      


Thr Asn Gln Ser Gly Leu Glu Arg Cys Glu Gly Glu Gln Asp Lys Arg 
            20                  25                  30          


Leu His Cys Tyr Ala Ser Trp Arg Asn Ser Ser Gly Thr Ile Glu Leu 
        35                  40                  45              


Val Lys Lys Gly Cys Trp Leu Asp Asp Phe Asn Cys Tyr Asp Arg Gln 
    50                  55                  60                  


Glu Cys Val Ala Lys Glu Glu Asn Pro Gln Val Tyr Phe Cys Cys Cys 
65                  70                  75                  80  


Glu Gly Asn Phe Cys Asn Glu Lys Phe Ser Tyr Phe Pro Gln Met Glu 
                85                  90                  95      


Val Thr Gln Pro Thr Ser Asn Pro Val Thr Pro Lys Pro Pro 
            100                 105                 110 


<210>  93
<211>  110
<212>  PRT
<213>  Artificial

<220>
<223>  Hybrid Human ActRIIB ECD

<400>  93

Glu Thr Arg Glu Cys Ile Tyr Tyr Asn Ala Asn Trp Glu Leu Glu Arg 
1               5                   10                  15      


Thr Asn Gln Ser Gly Leu Glu Arg Cys Glu Gly Glu Gln Asp Lys Arg 
            20                  25                  30          


Leu His Cys Tyr Ala Ser Trp Arg Asn Ser Ser Gly Thr Ile Glu Leu 
        35                  40                  45              


Val Lys Lys Gly Cys Trp Leu Asp Asp Phe Asn Cys Tyr Asp Arg Gln 
    50                  55                  60                  


Glu Cys Val Ala Thr Lys Glu Asn Pro Gln Val Tyr Phe Cys Cys Cys 
65                  70                  75                  80  


Glu Gly Asn Phe Cys Asn Glu Lys Phe Ser Tyr Phe Pro Gln Met Glu 
                85                  90                  95      


Val Thr Gln Pro Thr Ser Asn Pro Val Thr Pro Lys Pro Pro 
            100                 105                 110 


<210>  94
<211>  110
<212>  PRT
<213>  Artificial

<220>
<223>  Hybrid Human ActRIIB ECD

<400>  94

Glu Thr Arg Glu Cys Ile Tyr Tyr Asn Ala Asn Trp Glu Leu Glu Arg 
1               5                   10                  15      


Thr Asn Gln Ser Gly Leu Glu Arg Cys Glu Gly Glu Gln Asp Lys Arg 
            20                  25                  30          


Leu His Cys Tyr Ala Ser Trp Arg Asn Ser Ser Gly Thr Ile Glu Leu 
        35                  40                  45              


Val Lys Lys Gly Cys Trp Leu Asp Asp Phe Asn Cys Tyr Asp Arg Gln 
    50                  55                  60                  


Glu Cys Val Ala Thr Glu Asp Asn Pro Gln Val Tyr Phe Cys Cys Cys 
65                  70                  75                  80  


Glu Gly Asn Phe Cys Asn Glu Lys Phe Ser Tyr Phe Pro Gln Met Glu 
                85                  90                  95      


Val Thr Gln Pro Thr Ser Asn Pro Val Thr Pro Lys Pro Pro 
            100                 105                 110 


<210>  95
<211>  110
<212>  PRT
<213>  Artificial

<220>
<223>  Hybrid Human ActRIIB ECD

<400>  95

Glu Thr Arg Glu Cys Ile Tyr Tyr Asn Ala Asn Trp Glu Leu Glu Arg 
1               5                   10                  15      


Thr Asn Gln Ser Gly Leu Glu Arg Cys Glu Gly Glu Gln Asp Lys Arg 
            20                  25                  30          


Leu His Cys Tyr Ala Ser Trp Arg Asn Ser Ser Gly Thr Ile Glu Leu 
        35                  40                  45              


Val Lys Lys Gly Cys Trp Leu Asp Asp Phe Asn Cys Tyr Asp Arg Gln 
    50                  55                  60                  


Glu Cys Val Ala Thr Glu Glu Ser Pro Gln Val Tyr Phe Cys Cys Cys 
65                  70                  75                  80  


Glu Gly Asn Phe Cys Asn Glu Lys Phe Ser Tyr Phe Pro Gln Met Glu 
                85                  90                  95      


Val Thr Gln Pro Thr Ser Asn Pro Val Thr Pro Lys Pro Pro 
            100                 105                 110 


<210>  96
<211>  110
<212>  PRT
<213>  Artificial

<220>
<223>  Hybrid Human ActRIIB ECD

<400>  96

Glu Thr Arg Glu Cys Ile Tyr Tyr Asn Ala Asn Trp Glu Leu Glu Arg 
1               5                   10                  15      


Thr Asn Gln Ser Gly Leu Glu Arg Cys Glu Gly Glu Gln Asp Lys Arg 
            20                  25                  30          


Leu His Cys Tyr Ala Ser Trp Arg Asn Ser Ser Gly Thr Ile Glu Leu 
        35                  40                  45              


Val Lys Lys Gly Cys Trp Leu Asp Asp Phe Asn Cys Tyr Asp Arg Gln 
    50                  55                  60                  


Glu Cys Val Ala Thr Glu Glu Asn Pro Glu Val Tyr Phe Cys Cys Cys 
65                  70                  75                  80  


Glu Gly Asn Phe Cys Asn Glu Lys Phe Ser Tyr Phe Pro Gln Met Glu 
                85                  90                  95      


Val Thr Gln Pro Thr Ser Asn Pro Val Thr Pro Lys Pro Pro 
            100                 105                 110 


<210>  97
<211>  110
<212>  PRT
<213>  Artificial

<220>
<223>  Hybrid Human ActRIIB ECD

<400>  97

Glu Thr Arg Glu Cys Ile Tyr Tyr Asn Ala Asn Trp Glu Leu Glu Arg 
1               5                   10                  15      


Thr Asn Gln Ser Gly Leu Glu Arg Cys Glu Gly Asp Lys Asp Lys Arg 
            20                  25                  30          


Leu His Cys Tyr Ala Ser Trp Arg Asn Ser Ser Gly Thr Ile Glu Leu 
        35                  40                  45              


Val Lys Lys Gly Cys Trp Leu Asp Asp Phe Asn Cys Tyr Asp Arg Gln 
    50                  55                  60                  


Glu Cys Val Glu Thr Glu Glu Asn Pro Gln Val Tyr Phe Cys Cys Cys 
65                  70                  75                  80  


Glu Gly Asn Phe Cys Asn Glu Lys Phe Ser Tyr Phe Pro Gln Met Glu 
                85                  90                  95      


Val Thr Gln Pro Thr Ser Asn Pro Val Thr Pro Lys Pro Pro 
            100                 105                 110 


<210>  98
<211>  110
<212>  PRT
<213>  Artificial

<220>
<223>  Hybrid Human ActRIIB ECD

<400>  98

Glu Thr Arg Glu Cys Ile Tyr Tyr Asn Ala Asn Trp Glu Leu Glu Arg 
1               5                   10                  15      


Thr Asn Gln Ser Gly Leu Glu Arg Cys Glu Gly Glu Lys Asp Lys Arg 
            20                  25                  30          


Leu His Cys Tyr Ala Ser Trp Arg Asn Ser Ser Gly Thr Ile Glu Leu 
        35                  40                  45              


Val Lys Lys Gly Cys Trp Leu Asp Asp Phe Asn Cys Tyr Asp Arg Gln 
    50                  55                  60                  


Glu Cys Val Ala Lys Glu Glu Asn Pro Gln Val Tyr Phe Cys Cys Cys 
65                  70                  75                  80  


Glu Gly Asn Phe Cys Asn Glu Lys Phe Ser Tyr Phe Pro Gln Met Glu 
                85                  90                  95      


Val Thr Gln Pro Thr Ser Asn Pro Val Thr Pro Lys Pro Pro 
            100                 105                 110 


<210>  99
<211>  110
<212>  PRT
<213>  Artificial

<220>
<223>  Hybrid Human ActRIIB ECD

<400>  99

Glu Thr Arg Glu Cys Ile Tyr Tyr Asn Ala Asn Trp Glu Leu Glu Arg 
1               5                   10                  15      


Thr Asn Gln Ser Gly Leu Glu Arg Cys Glu Gly Asp Gln Asp Lys Arg 
            20                  25                  30          


Leu His Cys Tyr Ala Ser Trp Arg Asn Ser Ser Gly Thr Ile Glu Leu 
        35                  40                  45              


Val Lys Lys Gly Cys Trp Leu Asp Asp Phe Asn Cys Tyr Asp Arg Gln 
    50                  55                  60                  


Glu Cys Val Ala Thr Lys Glu Asn Pro Gln Val Tyr Phe Cys Cys Cys 
65                  70                  75                  80  


Glu Gly Asn Phe Cys Asn Glu Lys Phe Ser Tyr Phe Pro Gln Met Glu 
                85                  90                  95      


Val Thr Gln Pro Thr Ser Asn Pro Val Thr Pro Lys Pro Pro 
            100                 105                 110 


<210>  100
<211>  110
<212>  PRT
<213>  Artificial

<220>
<223>  Hybrid Human ActRIIB ECD

<400>  100

Glu Thr Arg Glu Cys Ile Tyr Tyr Asn Ala Asn Trp Glu Leu Glu Arg 
1               5                   10                  15      


Thr Asn Gln Ser Gly Leu Glu Arg Cys Glu Gly Asp Lys Asp Lys Arg 
            20                  25                  30          


Leu His Cys Tyr Ala Ser Trp Arg Asn Ser Ser Gly Thr Ile Glu Leu 
        35                  40                  45              


Val Lys Gln Gly Cys Trp Leu Asp Asp Phe Asn Cys Tyr Asp Arg Gln 
    50                  55                  60                  


Glu Cys Val Ala Lys Lys Glu Asn Pro Gln Val Tyr Phe Cys Cys Cys 
65                  70                  75                  80  


Glu Gly Asn Phe Cys Asn Glu Lys Phe Ser Tyr Phe Pro Gln Met Glu 
                85                  90                  95      


Val Thr Gln Pro Thr Ser Asn Pro Val Thr Pro Lys Pro Pro 
            100                 105                 110 


<210>  101
<211>  110
<212>  PRT
<213>  Artificial

<220>
<223>  Hybrid Human ActRIIB ECD

<400>  101

Glu Thr Arg Glu Cys Ile Tyr Tyr Asn Ala Asn Trp Glu Leu Glu Arg 
1               5                   10                  15      


Thr Asn Gln Ser Gly Leu Glu Arg Cys Glu Gly Asp Lys Asp Lys Arg 
            20                  25                  30          


Leu His Cys Tyr Ala Ser Trp Arg Asn Ser Ser Gly Thr Ile Glu Ile 
        35                  40                  45              


Val Lys Gln Gly Cys Trp Leu Asp Asp Phe Asn Cys Tyr Asp Arg Gln 
    50                  55                  60                  


Glu Cys Val Ala Glu Lys Glu Asn Pro Gln Val Tyr Phe Cys Cys Cys 
65                  70                  75                  80  


Glu Gly Asn Phe Cys Asn Glu Lys Phe Ser Tyr Phe Pro Gln Met Glu 
                85                  90                  95      


Val Thr Gln Pro Thr Ser Asn Pro Val Thr Pro Lys Pro Pro 
            100                 105                 110 


<210>  102
<211>  110
<212>  PRT
<213>  Artificial

<220>
<223>  Hybrid Human ActRIIB ECD

<400>  102

Glu Thr Arg Glu Cys Ile Tyr Tyr Asn Ala Asn Trp Glu Leu Glu Arg 
1               5                   10                  15      


Thr Asn Gln Ser Gly Leu Glu Arg Cys Tyr Gly Asp Gln Asp Lys Arg 
            20                  25                  30          


Leu His Cys Tyr Ala Ser Trp Arg Asn Ser Ser Gly Ser Ile Glu Ile 
        35                  40                  45              


Val Lys Gln Gly Cys Trp Leu Asp Asp Phe Asn Cys Tyr Asp Arg Gln 
    50                  55                  60                  


Glu Cys Val Ala Lys Lys Glu Asn Pro Gln Val Tyr Phe Cys Cys Cys 
65                  70                  75                  80  


Glu Gly Asn Phe Cys Asn Glu Lys Phe Ser Tyr Phe Pro Gln Met Glu 
                85                  90                  95      


Val Thr Gln Pro Thr Ser Asn Pro Val Thr Pro Lys Pro Pro 
            100                 105                 110 


<210>  103
<211>  110
<212>  PRT
<213>  Artificial

<220>
<223>  Hybrid Human ActRIIB ECD

<400>  103

Glu Thr Arg Glu Cys Ile Tyr Tyr Asn Ala Asn Trp Glu Leu Glu Arg 
1               5                   10                  15      


Thr Asn Gln Ser Gly Leu Glu Arg Cys Glu Gly Glu Lys Asp Lys Arg 
            20                  25                  30          


Arg His Cys Tyr Ala Ser Trp Arg Asn Ser Ser Gly Thr Ile Glu Ile 
        35                  40                  45              


Val Lys Lys Gly Cys Trp Leu Asp Asp Phe Asn Cys Tyr Asp Arg Gln 
    50                  55                  60                  


Glu Cys Val Ala Thr Lys Glu Asn Pro Gln Val Tyr Phe Cys Cys Cys 
65                  70                  75                  80  


Glu Gly Asn Phe Cys Asn Glu Lys Phe Ser Tyr Phe Pro Gln Met Glu 
                85                  90                  95      


Val Thr Gln Pro Thr Ser Asn Pro Val Thr Pro Lys Pro Pro 
            100                 105                 110 


<210>  104
<211>  110
<212>  PRT
<213>  Artificial

<220>
<223>  Hybrid Human ActRIIB ECD

<400>  104

Glu Thr Arg Glu Cys Ile Tyr Tyr Asn Ala Asn Trp Glu Leu Glu Arg 
1               5                   10                  15      


Thr Asn Gln Ser Gly Leu Glu Arg Cys Tyr Gly Asp Gln Asp Lys Arg 
            20                  25                  30          


Arg His Cys Tyr Ala Ser Trp Arg Asn Ser Ser Gly Thr Ile Glu Leu 
        35                  40                  45              


Val Lys Lys Gly Cys Trp Leu Asp Asp Phe Asn Cys Tyr Asp Arg Gln 
    50                  55                  60                  


Glu Cys Val Ala Thr Glu Glu Asn Pro Glu Val Tyr Phe Cys Cys Cys 
65                  70                  75                  80  


Glu Gly Asn Phe Cys Asn Glu Lys Phe Ser Tyr Phe Pro Gln Met Glu 
                85                  90                  95      


Val Thr Gln Pro Thr Ser Asn Pro Val Thr Pro Lys Pro Pro 
            100                 105                 110 


<210>  105
<211>  110
<212>  PRT
<213>  Artificial

<220>
<223>  Hybrid Human ActRIIB ECD

<400>  105

Glu Thr Arg Glu Cys Ile Tyr Tyr Asn Ala Asn Trp Glu Leu Glu Arg 
1               5                   10                  15      


Thr Asn Gln Ser Gly Leu Glu Arg Cys Glu Gly Glu Gln Asp Lys Arg 
            20                  25                  30          


Arg His Cys Tyr Ala Ser Trp Arg Asn Ser Ser Gly Thr Ile Glu Leu 
        35                  40                  45              


Val Lys Lys Gly Cys Trp Leu Asp Asp Phe Asn Cys Tyr Asp Arg Gln 
    50                  55                  60                  


Glu Cys Val Ala Thr Glu Glu Asn Pro Gln Val Tyr Phe Cys Cys Cys 
65                  70                  75                  80  


Glu Gly Asn Phe Cys Asn Glu Lys Phe Ser Tyr Phe Pro Gln Met Glu 
                85                  90                  95      


Val Thr Gln Pro Thr Ser Asn Pro Val Thr Pro Lys Pro Pro 
            100                 105                 110 


<210>  106
<211>  110
<212>  PRT
<213>  Artificial

<220>
<223>  Hybrid Human ActRIIB ECD

<400>  106

Glu Thr Arg Glu Cys Ile Tyr Tyr Asn Ala Asn Trp Glu Leu Glu Arg 
1               5                   10                  15      


Thr Asn Gln Ser Gly Leu Glu Arg Cys Tyr Gly Glu Gln Asp Lys Arg 
            20                  25                  30          


Leu His Cys Tyr Ala Ser Trp Arg Asn Ser Ser Gly Ser Ile Glu Ile 
        35                  40                  45              


Val Lys Lys Gly Cys Trp Leu Asp Asp Phe Asn Cys Tyr Asp Arg Thr 
    50                  55                  60                  


Asp Cys Val Ala Thr Glu Glu Asn Pro Gln Val Tyr Phe Cys Cys Cys 
65                  70                  75                  80  


Glu Gly Asn Phe Cys Asn Glu Lys Phe Ser Tyr Phe Pro Gln Met Glu 
                85                  90                  95      


Val Thr Gln Pro Thr Ser Asn Pro Val Thr Pro Lys Pro Pro 
            100                 105                 110 


<210>  107
<211>  110
<212>  PRT
<213>  Artificial

<220>
<223>  Hybrid Human ActRIIB ECD

<400>  107

Glu Thr Arg Glu Cys Ile Tyr Tyr Asn Ala Asn Trp Glu Leu Glu Arg 
1               5                   10                  15      


Thr Asn Gln Ser Gly Leu Glu Arg Cys Glu Gly Glu Gln Asp Lys Arg 
            20                  25                  30          


Arg His Cys Tyr Ala Ser Trp Arg Asn Ser Ser Gly Ser Ile Glu Leu 
        35                  40                  45              


Val Lys Lys Gly Cys Trp Leu Asp Asp Phe Asn Cys Tyr Asp Arg Gln 
    50                  55                  60                  


Glu Cys Val Ala Lys Glu Glu Asn Pro Gln Val Tyr Phe Cys Cys Cys 
65                  70                  75                  80  


Glu Gly Asn Phe Cys Asn Glu Lys Phe Ser Tyr Phe Pro Gln Met Glu 
                85                  90                  95      


Val Thr Gln Pro Thr Ser Asn Pro Val Thr Pro Lys Pro Pro 
            100                 105                 110 


<210>  108
<211>  110
<212>  PRT
<213>  Artificial

<220>
<223>  Hybrid Human ActRIIB ECD

<400>  108

Glu Thr Arg Glu Cys Ile Tyr Tyr Asn Ala Asn Trp Glu Leu Glu Arg 
1               5                   10                  15      


Thr Asn Gln Ser Gly Leu Glu Arg Cys Glu Gly Glu Gln Asp Lys Arg 
            20                  25                  30          


Arg His Cys Tyr Ala Ser Trp Arg Asn Ser Ser Gly Thr Ile Glu Ile 
        35                  40                  45              


Val Lys Lys Gly Cys Trp Leu Asp Asp Phe Asn Cys Tyr Asp Arg Gln 
    50                  55                  60                  


Glu Cys Val Ala Lys Glu Glu Asn Pro Gln Val Tyr Phe Cys Cys Cys 
65                  70                  75                  80  


Glu Gly Asn Phe Cys Asn Glu Lys Phe Ser Tyr Phe Pro Gln Met Glu 
                85                  90                  95      


Val Thr Gln Pro Thr Ser Asn Pro Val Thr Pro Lys Pro Pro 
            100                 105                 110 


<210>  109
<211>  110
<212>  PRT
<213>  Artificial

<220>
<223>  Hybrid Human ActRIIB ECD

<400>  109

Glu Thr Arg Glu Cys Ile Tyr Tyr Asn Ala Asn Trp Glu Leu Glu Arg 
1               5                   10                  15      


Thr Asn Gln Ser Gly Leu Glu Arg Cys Glu Gly Glu Gln Asp Lys Arg 
            20                  25                  30          


Arg His Cys Tyr Ala Ser Trp Arg Asn Ser Ser Gly Ser Ile Glu Ile 
        35                  40                  45              


Val Lys Lys Gly Cys Trp Leu Asp Asp Phe Asn Cys Tyr Asp Arg Gln 
    50                  55                  60                  


Glu Cys Val Ala Thr Lys Glu Asn Pro Gln Val Tyr Phe Cys Cys Cys 
65                  70                  75                  80  


Glu Gly Asn Phe Cys Asn Glu Lys Phe Ser Tyr Phe Pro Gln Met Glu 
                85                  90                  95      


Val Thr Gln Pro Thr Ser Asn Pro Val Thr Pro Lys Pro Pro 
            100                 105                 110 


<210>  110
<211>  110
<212>  PRT
<213>  Artificial

<220>
<223>  Hybrid Human ActRIIB ECD

<400>  110

Glu Thr Arg Glu Cys Ile Tyr Tyr Asn Ala Asn Trp Glu Leu Glu Arg 
1               5                   10                  15      


Thr Asn Gln Ser Gly Leu Glu Arg Cys Glu Gly Asp Gln Asp Lys Arg 
            20                  25                  30          


Leu His Cys Tyr Ala Ser Trp Arg Asn Ser Ser Gly Thr Ile Glu Ile 
        35                  40                  45              


Val Lys Lys Gly Cys Trp Leu Asp Asp Phe Asn Cys Tyr Asp Arg Gln 
    50                  55                  60                  


Glu Cys Val Ala Thr Lys Glu Asn Pro Gln Val Tyr Phe Cys Cys Cys 
65                  70                  75                  80  


Glu Gly Asn Phe Cys Asn Glu Lys Phe Ser Tyr Phe Pro Gln Met Glu 
                85                  90                  95      


Val Thr Gln Pro Thr Ser Asn Pro Val Thr Pro Lys Pro Pro 
            100                 105                 110 


<210>  111
<211>  110
<212>  PRT
<213>  Artificial

<220>
<223>  Hybrid Human ActRIIB ECD

<400>  111

Glu Thr Arg Glu Cys Ile Tyr Tyr Asn Ala Asn Trp Glu Leu Glu Arg 
1               5                   10                  15      


Thr Asn Gln Ser Gly Leu Glu Arg Cys Glu Gly Asp Gln Asp Lys Arg 
            20                  25                  30          


Leu His Cys Tyr Ala Ser Trp Arg Asn Ser Ser Gly Ser Ile Glu Leu 
        35                  40                  45              


Val Lys Lys Gly Cys Trp Leu Asp Asp Phe Asn Cys Tyr Asp Arg Gln 
    50                  55                  60                  


Glu Cys Val Ala Thr Lys Glu Asn Pro Gln Val Tyr Phe Cys Cys Cys 
65                  70                  75                  80  


Glu Gly Asn Phe Cys Asn Glu Lys Phe Ser Tyr Phe Pro Gln Met Glu 
                85                  90                  95      


Val Thr Gln Pro Thr Ser Asn Pro Val Thr Pro Lys Pro Pro 
            100                 105                 110 


<210>  112
<211>  110
<212>  PRT
<213>  Artificial

<220>
<223>  Hybrid Human ActRIIB ECD

<400>  112

Glu Thr Arg Glu Cys Ile Tyr Tyr Asn Ala Asn Trp Glu Leu Glu Arg 
1               5                   10                  15      


Thr Asn Gln Ser Gly Leu Glu Arg Cys Glu Gly Asp Gln Asp Lys Arg 
            20                  25                  30          


Leu His Cys Tyr Ala Ser Trp Arg Asn Ser Ser Gly Thr Ile Glu Leu 
        35                  40                  45              


Val Lys Lys Gly Cys Trp Leu Asp Asp Phe Asn Cys Tyr Asp Arg Gln 
    50                  55                  60                  


Glu Cys Val Ala Thr Lys Glu Asn Pro Gln Val Tyr Phe Cys Cys Cys 
65                  70                  75                  80  


Glu Gly Asn Phe Cys Asn Glu Lys Phe Ser Tyr Phe Pro Gln Met Glu 
                85                  90                  95      


Val Thr Gln Pro Thr Ser Asn Pro Val Thr Pro Lys Pro Pro 
            100                 105                 110 


<210>  113
<211>  110
<212>  PRT
<213>  Artificial

<220>
<223>  Hybrid Human ActRIIB ECD

<400>  113

Glu Thr Arg Glu Cys Ile Tyr Tyr Asn Ala Asn Trp Glu Leu Glu Arg 
1               5                   10                  15      


Thr Asn Gln Ser Gly Leu Glu Arg Cys Glu Gly Glu Gln Asp Lys Arg 
            20                  25                  30          


Leu His Cys Tyr Ala Ser Trp Arg Asn Ser Ser Gly Thr Ile Glu Ile 
        35                  40                  45              


Val Lys Lys Gly Cys Trp Leu Asp Asp Phe Asn Cys Tyr Asp Arg Gln 
    50                  55                  60                  


Glu Cys Val Ala Thr Lys Glu Asn Pro Gln Val Tyr Phe Cys Cys Cys 
65                  70                  75                  80  


Glu Gly Asn Phe Cys Asn Glu Lys Phe Ser Tyr Phe Pro Gln Met Glu 
                85                  90                  95      


Val Thr Gln Pro Thr Ser Asn Pro Val Thr Pro Lys Pro Pro 
            100                 105                 110 


<210>  114
<211>  110
<212>  PRT
<213>  Artificial

<220>
<223>  Hybrid Human ActRIIB ECD

<400>  114

Glu Thr Arg Glu Cys Ile Tyr Tyr Asn Ala Asn Trp Glu Leu Glu Arg 
1               5                   10                  15      


Thr Asn Gln Ser Gly Leu Glu Arg Cys Glu Gly Glu Gln Asp Lys Arg 
            20                  25                  30          


Leu His Cys Tyr Ala Ser Trp Arg Asn Ser Ser Gly Thr Ile Glu Leu 
        35                  40                  45              


Val Lys Lys Gly Cys Trp Leu Asp Asp Phe Asn Cys Tyr Asp Arg Gln 
    50                  55                  60                  


Glu Cys Val Ala Thr Lys Glu Asn Pro Gln Val Tyr Phe Cys Cys Cys 
65                  70                  75                  80  


Glu Gly Asn Phe Cys Asn Glu Lys Phe Ser Tyr Phe Pro Gln Met Glu 
                85                  90                  95      


Val Thr Gln Pro Thr Ser Asn Pro Val Thr Pro Lys Pro Pro 
            100                 105                 110 


<210>  115
<211>  110
<212>  PRT
<213>  Artificial

<220>
<223>  Hybrid Human ActRIIB ECD

<400>  115

Glu Thr Arg Glu Cys Ile Tyr Tyr Asn Ala Asn Trp Glu Leu Glu Arg 
1               5                   10                  15      


Thr Asn Gln Ser Gly Leu Glu Arg Cys Glu Gly Asp Gln Asp Lys Arg 
            20                  25                  30          


Leu His Cys Tyr Ala Ser Trp Arg Asn Ser Ser Gly Thr Ile Glu Ile 
        35                  40                  45              


Val Lys Lys Gly Cys Trp Leu Asp Asp Phe Asn Cys Tyr Asp Arg Gln 
    50                  55                  60                  


Glu Cys Val Ala Lys Lys Glu Asn Pro Gln Val Tyr Phe Cys Cys Cys 
65                  70                  75                  80  


Glu Gly Asn Phe Cys Asn Glu Lys Phe Ser Tyr Phe Pro Gln Met Glu 
                85                  90                  95      


Val Thr Gln Pro Thr Ser Asn Pro Val Thr Pro Lys Pro Pro 
            100                 105                 110 


<210>  116
<211>  110
<212>  PRT
<213>  Artificial

<220>
<223>  Hybrid Human ActRIIB ECD

<400>  116

Glu Thr Gln Glu Cys Leu Phe Phe Asn Ala Asn Trp Glu Lys Asp Arg 
1               5                   10                  15      


Thr Asn Gln Thr Gly Val Glu Pro Cys Tyr Gly Asp Lys Asp Lys Arg 
            20                  25                  30          


Arg His Cys Phe Ala Thr Trp Lys Asn Ile Ser Gly Ser Ile Glu Ile 
        35                  40                  45              


Val Lys Gln Gly Cys Trp Leu Asp Asp Ile Asn Cys Tyr Asp Arg Thr 
    50                  55                  60                  


Asp Cys Val Glu Lys Lys Asp Ser Pro Glu Val Tyr Phe Cys Cys Cys 
65                  70                  75                  80  


Glu Gly Asn Met Cys Asn Glu Arg Phe Thr His Leu Pro Glu Ala Gly 
                85                  90                  95      


Gly Pro Glu Val Thr Tyr Glu Pro Pro Pro Thr Ala Pro Thr 
            100                 105                 110 


<210>  117
<211>  110
<212>  PRT
<213>  Artificial

<220>
<223>  Hybrid Human ActRIIB ECD

<400>  117

Glu Thr Arg Glu Cys Ile Tyr Tyr Asn Ala Asn Trp Glu Leu Glu Arg 
1               5                   10                  15      


Thr Asn Gln Ser Gly Leu Glu Arg Cys Tyr Gly Asp Lys Asp Lys Arg 
            20                  25                  30          


Arg His Cys Tyr Ala Ser Trp Arg Asn Ser Ser Gly Thr Ile Glu Leu 
        35                  40                  45              


Val Lys Lys Gly Cys Trp Leu Asp Asp Ile Asn Cys Tyr Asp Arg Gln 
    50                  55                  60                  


Glu Cys Val Ala Thr Lys Glu Asn Pro Gln Val Tyr Phe Cys Cys Cys 
65                  70                  75                  80  


Glu Gly Asn Phe Cys Asn Glu Arg Phe Thr His Leu Pro Glu Ala Gly 
                85                  90                  95      


Gly Pro Glu Val Thr Tyr Glu Pro Pro Pro Thr Ala Pro Thr 
            100                 105                 110 


<210>  118
<211>  12
<212>  PRT
<213>  Artificial

<220>
<223>  Peptide linker

<400>  118

Glu Ser Lys Tyr Gly Pro Pro Cys Pro Pro Cys Pro 
1               5                   10          


