                         SEQUENCE LISTING

<110>  THE J. DAVID GLADSTONE INSTITUTES
       LINSLEY, Jeremy
       SHAH, Kevan
       FINKBEINER, Steven M.
 
<120>  GENETICALLY ENCODED CELL DEATH INDICATORS AND METHODS OF USE

<130>  120902-8007.WO00

<150>  US 62/409,941
<151>  2016-10-19

<160>  12    

<170>  PatentIn version 3.5

<210>  1
<211>  1353
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  GCaMP

<400>  1
atgggttctc atcatcatca tcatcatggt atggctagca tgactggtgg acagcaaatg       60

ggtcgggatc tgtacgacga tgacgataag gatctcgcca ccatggtcga ctcatcacgt      120

cgtaagtgga ataagacagg tcacgcagtc agagctatag gtcggctgag ctcactcgag      180

aacgtctata tcaaggccga caagcagaag aacggcatca aggcgaactt caagatccgc      240

cacaacatcg aggacggcgg cgtgcagctc gcctaccact accagcagaa cacccccatc      300

ggcgacggcc ccgtgctgct gcccgacaac cactacctga gcgtgcagtc caaactttcg      360

aaagacccca acgagaagcg cgatcacatg gtcctgctgg agttcgtgac cgccgccggg      420

atcactctcg gcatggacga gctgtacaag ggcggtaccg gagggagcat ggtgagcaag      480

ggcgaggagc tgttcaccgg ggtggtgccc atcctggtcg agctggacgg cgacgtaaac      540

ggccacaagt tcagcgtgtc cggcgagggt gagggcgatg ccacctacgg caagctgacc      600

ctgaagttca tctgcaccac cggcaagctg cccgtgccct ggcccaccct cgtgaccacc      660

ctgacctacg gcgtgcagtg cttcagccgc taccccgacc acatgaagca gcacgacttc      720

ttcaagtccg ccatgcccga aggctacatc caggagcgca ccatcttctt caaggacgac      780

ggcaactaca agacccgcgc cgaggtgaag ttcgagggcg acaccctggt gaaccgcatc      840

gagctgaagg gcatcgactt caaggaggac ggcaacatcc tggggcacaa gctggagtac      900

aacctgccgg accaactgac tgaagagcag atcgcagaat ttaaagagga attctcccta      960

tttgacaagg acggggatgg gacaataaca accaaggagc tggggacggt gatgcggtct     1020

ctggggcaga accccacaga agcagagctg caggacatga tcaatgaagt agatgccgac     1080

ggtgacggca caatcgactt ccctgagttc ctgacaatga tggcaagaaa aatgaaatac     1140

agggacacgg aagaagaaat tagagaagcg ttcggtgtgt ttgataagga tggcaatggc     1200

tacatcagtg cagcagagct tcgccacgtg atgacaaacc ttggagagaa gttaacagat     1260

gaagaggttg atgaaatgat cagggaagca gacatcgatg gggatggtca ggtaaactac     1320

gaagagtttg tacaaatgat gacagcgaag tga                                  1353


<210>  2
<211>  1251
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CEPIA - Suzuki

<400>  2
atggtcgact cttcacgtcg taagtggaat aagacaggtc acgcagtcag agctataggt       60

cggctgagct caccagagaa cgtgtatata aaggccgacg agcagaagaa cggcatcaag      120

gcgtacttca agatccgcca caacatcgag ggcggcggcg tgcagctcgc ctaccactac      180

cagcagatca cccccatagg cgacggcccc gtgctgctgc ccgacaacca ctacctgagc      240

gtgcagtcca tactttcgaa agaccccaac gagaagcgcg atcacatggt cctgctggag      300

ttcgtgaccg ccgccgggat cactctcggc atggacgagc tgtacaaggg tggcagcggt      360

ggcatggtga gcaagggcga ggagctgttc accggggtgg tgcccatcca ggtcgagctg      420

gacggcgacg taaacggcca caagttcagc gtgtccggcg agggtgaggg cgatgccacc      480

tacggcaagc tgaccctgaa gttcatctgc accaccggca agctgcccgt gccctggccc      540

accctcgtga ccaccctgtc ctacggcgtg cagtgcttca gccgctaccc cgaccacatg      600

aagcagcacg acttcttcaa gtccgccatg cccgaaggct acatccagga gcgcaccatc      660

ttcttcaagg acgacggcaa ctacaagacc cgcgccgagg tgaagttcga gggcgacacc      720

ctggtgaacc gcatcgagct gaagggcatc gacttcaagg aggacggcaa catcctgggg      780

cacaagctgg agtacagcac gcgtgaccaa ctgactgaag agcagatcgc agaatttaaa      840

gaggctttct ccctatttga caaggacggg gatgggacga taacaaccaa ggatctgggg      900

acggtgatgc ggtctctggg gcagaacccc acagaagcag agctccagga catgatcaat      960

gaagtagatg ccgacggtga cggcacaatc gacttccctg agttcctgac aatgatggca     1020

cctaaaatgc aggacacaga cagtgaagag gaaattcgcg aagcgttccg tgtgtgggat     1080

aaggatggca atggctacat cggcgcagca gagcttcgcc acgtgatgac aaaccttgga     1140

gagaagttaa cagatgaaga ggttgatgaa atgatcaggg tagcagacat cgatggagaa     1200

ggtcaggtaa actacgaaga ctttgtacaa atgatgacag cgaaggcggc c              1251


<210>  3
<211>  450
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GCaMP

<400>  3

Met Gly Ser His His His His His His Gly Met Ala Ser Met Thr Gly 
1               5                   10                  15      


Gly Gln Gln Met Gly Arg Asp Leu Tyr Asp Asp Asp Asp Lys Asp Leu 
            20                  25                  30          


Ala Thr Met Val Asp Ser Ser Arg Arg Lys Trp Asn Lys Thr Gly His 
        35                  40                  45              


Ala Val Arg Ala Ile Gly Arg Leu Ser Ser Leu Glu Asn Val Tyr Ile 
    50                  55                  60                  


Lys Ala Asp Lys Gln Lys Asn Gly Ile Lys Ala Asn Phe Lys Ile Arg 
65                  70                  75                  80  


His Asn Ile Glu Asp Gly Gly Val Gln Leu Ala Tyr His Tyr Gln Gln 
                85                  90                  95      


Asn Thr Pro Ile Gly Asp Gly Pro Val Leu Leu Pro Asp Asn His Tyr 
            100                 105                 110         


Leu Ser Val Gln Ser Lys Leu Ser Lys Asp Pro Asn Glu Lys Arg Asp 
        115                 120                 125             


His Met Val Leu Leu Glu Phe Val Thr Ala Ala Gly Ile Thr Leu Gly 
    130                 135                 140                 


Met Asp Glu Leu Tyr Lys Gly Gly Thr Gly Gly Ser Met Val Ser Lys 
145                 150                 155                 160 


Gly Glu Glu Leu Phe Thr Gly Val Val Pro Ile Leu Val Glu Leu Asp 
                165                 170                 175     


Gly Asp Val Asn Gly His Lys Phe Ser Val Ser Gly Glu Gly Glu Gly 
            180                 185                 190         


Asp Ala Thr Tyr Gly Lys Leu Thr Leu Lys Phe Ile Cys Thr Thr Gly 
        195                 200                 205             


Lys Leu Pro Val Pro Trp Pro Thr Leu Val Thr Thr Leu Thr Tyr Gly 
    210                 215                 220                 


Val Gln Cys Phe Ser Arg Tyr Pro Asp His Met Lys Gln His Asp Phe 
225                 230                 235                 240 


Phe Lys Ser Ala Met Pro Glu Gly Tyr Ile Gln Glu Arg Thr Ile Phe 
                245                 250                 255     


Phe Lys Asp Asp Gly Asn Tyr Lys Thr Arg Ala Glu Val Lys Phe Glu 
            260                 265                 270         


Gly Asp Thr Leu Val Asn Arg Ile Glu Leu Lys Gly Ile Asp Phe Lys 
        275                 280                 285             


Glu Asp Gly Asn Ile Leu Gly His Lys Leu Glu Tyr Asn Thr Arg Asp 
    290                 295                 300                 


Gln Leu Thr Glu Glu Gln Ile Ala Glu Phe Lys Glu Ala Phe Ser Leu 
305                 310                 315                 320 


Phe Asp Lys Asp Gly Asp Gly Thr Ile Thr Thr Lys Glu Leu Gly Thr 
                325                 330                 335     


Val Met Arg Ser Leu Gly Gln Asn Pro Thr Glu Ala Glu Leu Gln Asp 
            340                 345                 350         


Met Ile Asn Glu Val Asp Ala Asp Gly Asp Gly Thr Ile Asp Phe Pro 
        355                 360                 365             


Glu Phe Leu Thr Met Met Ala Arg Lys Met Lys Asp Thr Asp Ser Glu 
    370                 375                 380                 


Glu Glu Ile Arg Glu Ala Phe Arg Val Phe Asp Lys Asp Gly Asn Gly 
385                 390                 395                 400 


Tyr Ile Ser Ala Ala Glu Leu Arg His Val Met Thr Asn Leu Gly Glu 
                405                 410                 415     


Lys Leu Thr Asp Glu Glu Val Asp Glu Met Ile Arg Glu Ala Asp Ile 
            420                 425                 430         


Asp Gly Asp Gly Gln Val Asn Tyr Glu Glu Phe Val Gln Met Met Thr 
        435                 440                 445             


Ala Lys 
    450 


<210>  4
<211>  417
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CEPIA Sequence - Suzuki

<400>  4

Met Val Asp Ser Ser Arg Arg Lys Trp Asn Lys Thr Gly His Ala Val 
1               5                   10                  15      


Arg Ala Ile Gly Arg Leu Ser Ser Pro Glu Asn Val Tyr Ile Lys Ala 
            20                  25                  30          


Asp Glu Gln Lys Asn Gly Ile Lys Ala Tyr Phe Lys Ile Arg His Asn 
        35                  40                  45              


Ile Glu Gly Gly Gly Val Gln Leu Ala Tyr His Tyr Gln Gln Ile Thr 
    50                  55                  60                  


Pro Ile Gly Asp Gly Pro Val Leu Leu Pro Asp Asn His Tyr Leu Ser 
65                  70                  75                  80  


Val Gln Ser Ile Leu Ser Lys Asp Pro Asn Glu Lys Arg Asp His Met 
                85                  90                  95      


Val Leu Leu Glu Phe Val Thr Ala Ala Gly Ile Thr Leu Gly Met Asp 
            100                 105                 110         


Glu Leu Tyr Lys Gly Gly Ser Gly Gly Met Val Ser Lys Gly Glu Glu 
        115                 120                 125             


Leu Phe Thr Gly Val Val Pro Ile Gln Val Glu Leu Asp Gly Asp Val 
    130                 135                 140                 


Asn Gly His Lys Phe Ser Val Ser Gly Glu Gly Glu Gly Asp Ala Thr 
145                 150                 155                 160 


Tyr Gly Lys Leu Thr Leu Lys Phe Ile Cys Thr Thr Gly Lys Leu Pro 
                165                 170                 175     


Val Pro Trp Pro Thr Leu Val Thr Thr Leu Ser Tyr Gly Val Gln Cys 
            180                 185                 190         


Phe Ser Arg Tyr Pro Asp His Met Lys Gln His Asp Phe Phe Lys Ser 
        195                 200                 205             


Ala Met Pro Glu Gly Tyr Ile Gln Glu Arg Thr Ile Phe Phe Lys Asp 
    210                 215                 220                 


Asp Gly Asn Tyr Lys Thr Arg Ala Glu Val Lys Phe Glu Gly Asp Thr 
225                 230                 235                 240 


Leu Val Asn Arg Ile Glu Leu Lys Gly Ile Asp Phe Lys Glu Asp Gly 
                245                 250                 255     


Asn Ile Leu Gly His Lys Leu Glu Tyr Ser Thr Arg Asp Gln Leu Thr 
            260                 265                 270         


Glu Glu Gln Ile Ala Glu Phe Lys Glu Ala Phe Ser Leu Phe Asp Lys 
        275                 280                 285             


Asp Gly Asp Gly Thr Ile Thr Thr Lys Asp Leu Gly Thr Val Met Arg 
    290                 295                 300                 


Ser Leu Gly Gln Asn Pro Thr Glu Ala Glu Leu Gln Asp Met Ile Asn 
305                 310                 315                 320 


Glu Val Asp Ala Asp Gly Asp Gly Thr Ile Asp Phe Pro Glu Phe Leu 
                325                 330                 335     


Thr Met Met Ala Pro Lys Met Gln Asp Thr Asp Ser Glu Glu Glu Ile 
            340                 345                 350         


Arg Glu Ala Phe Arg Val Trp Asp Lys Asp Gly Asn Gly Tyr Ile Gly 
        355                 360                 365             


Ala Ala Glu Leu Arg His Val Met Thr Asn Leu Gly Glu Lys Leu Thr 
    370                 375                 380                 


Asp Glu Glu Val Asp Glu Met Ile Arg Val Ala Asp Ile Asp Gly Glu 
385                 390                 395                 400 


Gly Gln Val Asn Tyr Glu Asp Phe Val Gln Met Met Thr Ala Lys Ala 
                405                 410                 415     


Ala 
    


<210>  5
<211>  148
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Calmodulin

<400>  5

Ala Asp Gln Leu Thr Glu Glu Gln Ile Ala Glu Phe Lys Glu Ala Phe 
1               5                   10                  15      


Ser Leu Phe Asp Lys Asp Gly Asp Gly Thr Ile Thr Thr Lys Glu Leu 
            20                  25                  30          


Gly Thr Val Met Arg Ser Leu Gly Gln Asn Pro Thr Glu Ala Glu Leu 
        35                  40                  45              


Gln Asp Met Ile Asn Glu Val Asp Ala Asp Gly Asn Gly Thr Ile Asp 
    50                  55                  60                  


Phe Pro Glu Phe Leu Thr Met Met Ala Arg Lys Met Lys Asp Thr Asp 
65                  70                  75                  80  


Ser Glu Glu Glu Ile Arg Glu Ala Phe Arg Val Phe Asp Lys Asp Gly 
                85                  90                  95      


Asn Gly Tyr Ile Ser Ala Ala Glu Leu Arg His Val Met Thr Asn Leu 
            100                 105                 110         


Gly Glu Lys Leu Thr Asp Glu Glu Val Asp Glu Met Ile Arg Glu Ala 
        115                 120                 125             


Asp Ile Asp Gly Asp Gly Gln Val Asn Tyr Glu Glu Phe Val Gln Met 
    130                 135                 140                 


Met Thr Ala Lys 
145             


<210>  6
<211>  6213
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Hsyn1:RGEDI-P2a-EGFP

<400>  6
ctaaattgta agcgttaata ttttgttaaa attcgcgtta aatttttgtt aaatcagctc       60

attttttaac caataggccg aaatcggcaa aatcccttat aaatcaaaag aatagaccga      120

gatagggttg agtgttgttc cagtttggaa caagagtcca ctattaaaga acgtggactc      180

caacgtcaaa gggcgaaaaa ccgtctatca gggcgatggc ccactacgtg aaccatcacc      240

ctaatcaagt tttttggggt cgaggtgccg taaagcacta aatcggaacc ctaaagggag      300

cccccgattt agagcttgac ggggaaagcc ggcgaacgtg gcgagaaagg aagggaagaa      360

agcgaaagga gcgggcgcta gggcgctggc aagtgtagcg gtcacgctgc gcgtaaccac      420

cacacccgcc gcgcttaatg cgccgctaca gggcgcgtcc cattcgccat tcaggctgcg      480

caactgttgg gaagggcgat cggtgcgggc ctcttcgcta ttacgccagc tggcgaaagg      540

gggatgtgct gcaaggcgat taagttgggt aacgccaggg ttttcccagt cacgacgttg      600

taaaacgacg gccagtgagc gcgcgtaata cgactcacta tagggcgaat tgggtaccgg      660

gctgcagagg gccctgcgta tgagtgcaag tgggttttag gaccaggatg aggcggggtg      720

ggggtgccta cctgacgacc gaccccgacc cactggacaa gcacccaacc cccattcccc      780

aaattgcgca tcccctatca gagaggggga ggggaaacag gatgcggcga ggcgcgtgcg      840

cactgccagc ttcagcaccg cggacagtgc cttcgccccc gcctggcggc gcgcgccacc      900

gccgcctcag cactgaaggc gcgctgacgt cactcgccgg tcccccgcaa actccccttc      960

ccggccacct tggtcgcgtc cgcgccgccg ccggcccagc cggaccgcac cacgcgaggc     1020

gcgagatagg ggggcacggg cgcgaccatc tgcgctgcgg cgccggcgac tcagcgctgc     1080

ctcagtctgc ggtgggcagc ggaggagtcg tgtcgtgcct gagagcgcag tcgaattcaa     1140

gctgctagct agtaccggtc ctagggcccc ccccctcgag gtcgacggta tcgataagct     1200

tgccgccacc atgggtgaca atgacatcca ctttgccttt ctctccacag gcgcgcactc     1260

ccaggtccaa ctgcagggat ccatggtcga ctcttcacgt cgtaagtgga ataaggcagg     1320

tcacgcagtc agagctatag gtcggctgag ctcacccgtg gtttccgagc ggatgtaccc     1380

cgaggacggc gccctgaaga gcgagatcaa gaaggggctg aggctgaagg acggcggcca     1440

ctacgccgcc gaggtcaaga ccacctacaa ggccaagaag cccgtgcagc tgcccggcgc     1500

ctacatcgtc gacatcaagt tggacatcgt gtcccacaac gaggactaca ccatcgtgga     1560

acagtgcgaa cgcgccgagg gccgccactc caccggcggc atggacgagc tgtacaaggg     1620

aggtacaggc gggagtctgg tgagcaaggg cgaggaggat aacatggcca tcatcaagga     1680

gttcatgcgc ttcaaggtgc acatggaggg ctccgtgaac ggccacgagt tcgagatcga     1740

gggcgagggc gagggccgcc cctacgaggc ctttcagacc gctaagctga aggtgaccaa     1800

gggtggcccc ctgcccttcg cctgggacat cctgtcccct cagttcatgt acggctccaa     1860

ggcctacatt aagcacccag ccgacatccc cgactacttc aagctgtcct tccccgaggg     1920

cttcaggtgg gagcgcgtga tgaacttcga ggacggcggc attattcacg ttaaccagga     1980

ctcctccctg caggacggcg tattcatcta caaggtgaag ctgcgcggca ccaacttccc     2040

ccccgacggc cccgtaatgc agaagaagac catgggctgg gaggctactc gagaccaact     2100

gactgaagag cagatcgcag aatttaaaga ggctttctcc ctatttgaca aggacgggga     2160

tgggacaata acaaccaagg atctggggac ggtgctgcgg tctctggggc agaaccccac     2220

agaagcagag ctccaggaca tgatcaatga agtagatgcc gacggtaatg gcacaatcga     2280

cttccctgat ttcctgacaa tgatggcaag aaaaatgaaa gacacagaca gtgaagaaga     2340

aattcgcgaa gcgttccgtg tgtgggataa ggatggcaat ggctacatct ctgcagcaga     2400

ccttcgccac gtgatgacaa accttggaga gaagttaaca gatgaagagg ttgatgaaat     2460

gatcagggaa gcagatatcg atggagaagg tcaggtaaac tacgaagagt ttgtacaaat     2520

gatgacagcg aaggcggccg cagaacaaaa actcatctca gaagaggatc tgaatggggc     2580

cgcaagcgag ggatccggat ccggagccac gaacttctct ctgttaaagc aagcaggaga     2640

cgtggaagaa aaccccggtc ctatggtgag caagggcgag gagctgttca ccggggtggt     2700

gcccatcctg gtcgagctgg acggcgacgt aaacggccac aagttcagcg tgtccggcga     2760

gggcgagggc gatgccacct acggcaagct gaccctgaag ttcatctgca ccaccggcaa     2820

gctgcccgtg ccctggccca ccctcgtgac caccctgacc tacggcgtgc agtgcttcag     2880

ccgctacccc gaccacatga agcagcacga cttcttcaag tccgccatgc ccgaaggcta     2940

cgtccaggag cgcaccatct tcttcaagga cgacggcaac tacaagaccc gcgccgaggt     3000

gaagttcgag ggcgacaccc tggtgaaccg catcgagctg aagggcatcg acttcaagga     3060

ggacggcaac atcctggggc acaagctgga gtacaactac aacagccaca acgtctatat     3120

catggccgac aagcagaaga acggcatcaa ggtgaacttc aagatccgcc acaacatcga     3180

ggacggcagc gtgcagctcg ccgaccacta ccagcagaac acccccatcg gcgacggccc     3240

cgtgctgctg cccgacaacc actacctgag cacccagtcc gccctgagca aagaccccaa     3300

cgagaagcgc gatcacatgg tcctgctgga gttcgtgacc gccgccggga tcactctcgg     3360

catggacgag ctgtacaagt aaactagttc tagagcggcc gccaccgcgg tgtcgataat     3420

caacctctgg attacaaaat ttgtgaaaga ttgactggta ttcttaacta tgttgctcct     3480

tttacgctat gtggatacgc tgctttaatg cctttgtatc atgctattgc ttcccgtatg     3540

gctttcattt tctcctcctt gtataaatcc tggttgctgt ctctttatga ggagttgtgg     3600

cccgttgtca ggcaacgtgg cgtggtgtgc actgtgtttg ctgacgcaac ccccactggt     3660

tggggcattg ccaccacctg tcagctcctt tccgggactt tcgctttccc cctccctatt     3720

gccacggcgg aactcatcgc cgcctgcctt gcccgctgct ggacaggggc tcggctgttg     3780

ggcactgaca attccgtggt gttgtcgggg aaatcatcgt cctttccttg gctgctcgcc     3840

tgtgttgcca cctggattct gcgcgggacg tccttctgct acgtcccttc ggccctcaat     3900

ccagcggacc ttccttcccg cggcctgctg ccggctctgc ggcctcttcc gcgtcttcgc     3960

cttcgccctc agacgagtcg gatctccctt tgggccgcct ccccgcgagc tccagctttt     4020

gttcccttta gtgagggtta attgcgcgct tggcgtaatc atggtcatag ctgtttcctg     4080

tgtgaaattg ttatccgctc acaattccac acaacatacg agccggaagc ataaagtgta     4140

aagcctgggg tgcctaatga gtgagctaac tcacattaat tgcgttgcgc tcactgcccg     4200

ctttccagtc gggaaacctg tcgtgccagc tgcattaatg aatcggccaa cgcgcgggga     4260

gaggcggttt gcgtattggg cgctcttccg cttcctcgct cactgactcg ctgcgctcgg     4320

tcgttcggct gcggcgagcg gtatcagctc actcaaaggc ggtaatacgg ttatccacag     4380

aatcagggga taacgcagga aagaacatgt gagcaaaagg ccagcaaaag gccaggaacc     4440

gtaaaaaggc cgcgttgctg gcgtttttcc ataggctccg cccccctgac gagcatcaca     4500

aaaatcgacg ctcaagtcag aggtggcgaa acccgacagg actataaaga taccaggcgt     4560

ttccccctgg aagctccctc gtgcgctctc ctgttccgac cctgccgctt accggatacc     4620

tgtccgcctt tctcccttcg ggaagcgtgg cgctttctca tagctcacgc tgtaggtatc     4680

tcagttcggt gtaggtcgtt cgctccaagc tgggctgtgt gcacgaaccc cccgttcagc     4740

ccgaccgctg cgccttatcc ggtaactatc gtcttgagtc caacccggta agacacgact     4800

tatcgccact ggcagcagcc actggtaaca ggattagcag agcgaggtat gtaggcggtg     4860

ctacagagtt cttgaagtgg tggcctaact acggctacac tagaaggaca gtatttggta     4920

tctgcgctct gctgaagcca gttaccttcg gaaaaagagt tggtagctct tgatccggca     4980

aacaaaccac cgctggtagc ggtggttttt ttgtttgcaa gcagcagatt acgcgcagaa     5040

aaaaaggatc tcaagaagat cctttgatct tttctacggg gtctgacgct cagtggaacg     5100

aaaactcacg ttaagggatt ttggtcatga gattatcaaa aaggatcttc acctagatcc     5160

ttttaaatta aaaatgaagt tttaaatcaa tctaaagtat atatgagtaa acttggtctg     5220

acagttacca atgcttaatc agtgaggcac ctatctcagc gatctgtcta tttcgttcat     5280

ccatagttgc ctgactcccc gtcgtgtaga taactacgat acgggagggc ttaccatctg     5340

gccccagtgc tgcaatgata ccgcgagacc cacgctcacc ggctccagat ttatcagcaa     5400

taaaccagcc agccggaagg gccgagcgca gaagtggtcc tgcaacttta tccgcctcca     5460

tccagtctat taattgttgc cgggaagcta gagtaagtag ttcgccagtt aatagtttgc     5520

gcaacgttgt tgccattgct acaggcatcg tggtgtcacg ctcgtcgttt ggtatggctt     5580

cattcagctc cggttcccaa cgatcaaggc gagttacatg atcccccatg ttgtgcaaaa     5640

aagcggttag ctccttcggt cctccgatcg ttgtcagaag taagttggcc gcagtgttat     5700

cactcatggt tatggcagca ctgcataatt ctcttactgt catgccatcc gtaagatgct     5760

tttctgtgac tggtgagtac tcaaccaagt cattctgaga atagtgtatg cggcgaccga     5820

gttgctcttg cccggcgtca atacgggata ataccgcgcc acatagcaga actttaaaag     5880

tgctcatcat tggaaaacgt tcttcggggc gaaaactctc aaggatctta ccgctgttga     5940

gatccagttc gatgtaaccc actcgtgcac ccaactgatc ttcagcatct tttactttca     6000

ccagcgtttc tgggtgagca aaaacaggaa ggcaaaatgc cgcaaaaaag ggaataaggg     6060

cgacacggaa atgttgaata ctcatactct tcctttttca atattattga agcatttatc     6120

agggttattg tctcatgagc ggatacatat ttgaatgtat ttagaaaaat aaacaaatag     6180

gggttccgcg cacatttccc cgaaaagtgc cac                                  6213


<210>  7
<211>  6228
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Hsyn1:RGEDI-P2a-TagBFP2

<400>  7
ctaaattgta agcgttaata ttttgttaaa attcgcgtta aatttttgtt aaatcagctc       60

attttttaac caataggccg aaatcggcaa aatcccttat aaatcaaaag aatagaccga      120

gatagggttg agtgttgttc cagtttggaa caagagtcca ctattaaaga acgtggactc      180

caacgtcaaa gggcgaaaaa ccgtctatca gggcgatggc ccactacgtg aaccatcacc      240

ctaatcaagt tttttggggt cgaggtgccg taaagcacta aatcggaacc ctaaagggag      300

cccccgattt agagcttgac ggggaaagcc ggcgaacgtg gcgagaaagg aagggaagaa      360

agcgaaagga gcgggcgcta gggcgctggc aagtgtagcg gtcacgctgc gcgtaaccac      420

cacacccgcc gcgcttaatg cgccgctaca gggcgcgtcc cattcgccat tcaggctgcg      480

caactgttgg gaagggcgat cggtgcgggc ctcttcgcta ttacgccagc tggcgaaagg      540

gggatgtgct gcaaggcgat taagttgggt aacgccaggg ttttcccagt cacgacgttg      600

taaaacgacg gccagtgagc gcgcgtaata cgactcacta tagggcgaat tgggtaccgg      660

gctgcagagg gccctgcgta tgagtgcaag tgggttttag gaccaggatg aggcggggtg      720

ggggtgccta cctgacgacc gaccccgacc cactggacaa gcacccaacc cccattcccc      780

aaattgcgca tcccctatca gagaggggga ggggaaacag gatgcggcga ggcgcgtgcg      840

cactgccagc ttcagcaccg cggacagtgc cttcgccccc gcctggcggc gcgcgccacc      900

gccgcctcag cactgaaggc gcgctgacgt cactcgccgg tcccccgcaa actccccttc      960

ccggccacct tggtcgcgtc cgcgccgccg ccggcccagc cggaccgcac cacgcgaggc     1020

gcgagatagg ggggcacggg cgcgaccatc tgcgctgcgg cgccggcgac tcagcgctgc     1080

ctcagtctgc ggtgggcagc ggaggagtcg tgtcgtgcct gagagcgcag tcgaattcaa     1140

gctgctagct agtaccggtc ctagggcccc ccccctcgag gtcgacggta tcgataagct     1200

tgccgccacc atgggtgaca atgacatcca ctttgccttt ctctccacag gcgcgcactc     1260

ccaggtccaa ctgcagggat ccatggtcga ctcttcacgt cgtaagtgga ataaggcagg     1320

tcacgcagtc agagctatag gtcggctgag ctcacccgtg gtttccgagc ggatgtaccc     1380

cgaggacggc gccctgaaga gcgagatcaa gaaggggctg aggctgaagg acggcggcca     1440

ctacgccgcc gaggtcaaga ccacctacaa ggccaagaag cccgtgcagc tgcccggcgc     1500

ctacatcgtc gacatcaagt tggacatcgt gtcccacaac gaggactaca ccatcgtgga     1560

acagtgcgaa cgcgccgagg gccgccactc caccggcggc atggacgagc tgtacaaggg     1620

aggtacaggc gggagtctgg tgagcaaggg cgaggaggat aacatggcca tcatcaagga     1680

gttcatgcgc ttcaaggtgc acatggaggg ctccgtgaac ggccacgagt tcgagatcga     1740

gggcgagggc gagggccgcc cctacgaggc ctttcagacc gctaagctga aggtgaccaa     1800

gggtggcccc ctgcccttcg cctgggacat cctgtcccct cagttcatgt acggctccaa     1860

ggcctacatt aagcacccag ccgacatccc cgactacttc aagctgtcct tccccgaggg     1920

cttcaggtgg gagcgcgtga tgaacttcga ggacggcggc attattcacg ttaaccagga     1980

ctcctccctg caggacggcg tattcatcta caaggtgaag ctgcgcggca ccaacttccc     2040

ccccgacggc cccgtaatgc agaagaagac catgggctgg gaggctactc gagaccaact     2100

gactgaagag cagatcgcag aatttaaaga ggctttctcc ctatttgaca aggacgggga     2160

tgggacaata acaaccaagg atctggggac ggtgctgcgg tctctggggc agaaccccac     2220

agaagcagag ctccaggaca tgatcaatga agtagatgcc gacggtaatg gcacaatcga     2280

cttccctgat ttcctgacaa tgatggcaag aaaaatgaaa gacacagaca gtgaagaaga     2340

aattcgcgaa gcgttccgtg tgtgggataa ggatggcaat ggctacatct ctgcagcaga     2400

ccttcgccac gtgatgacaa accttggaga gaagttaaca gatgaagagg ttgatgaaat     2460

gatcagggaa gcagatatcg atggagaagg tcaggtaaac tacgaagagt ttgtacaaat     2520

gatgacagcg aaggcggccg cagaacaaaa actcatctca gaagaggatc tgaatggggc     2580

cgcaagcgag ggatccggat ccggagccac gaacttctct ctgttaaagc aagcaggaga     2640

cgtggaagaa aaccccggtc ctgggagcca ccatcaccat caccatggca gatctatgag     2700

cgagctgatt aaggagaaca tgcacatgaa gctgtacatg gagggcaccg tggacaacca     2760

tcacttcaag tgcacatccg agggcgaagg caagccctac gagggcaccc agaccatgag     2820

aatcaaggtg gtcgagggcg gccctctccc cttcgccttc gacatcctgg ctactagctt     2880

cctctacggc agcaagacct tcatcaacca cacccagggc atccccgact tcttcaagca     2940

gtccttccct gagggcttca catgggagag agtcaccaca tacgaagacg ggggcgtgct     3000

gaccgctacc caggacacca gcctccagga cggctgcctc atctacaacg tcaagatcag     3060

aggggtgaac ttcacatcca acggccctgt gatgcagaag aaaacactcg gctgggaggc     3120

cttcaccgag acgctgtacc ccgctgacgg cggcctggaa ggcagaaacg acatggccct     3180

gaagctcgtg ggcgggagcc atctgatcgc aaacgccaag accacatata gatccaagaa     3240

acccgctaag aacctcaaga tgcctggcgt ctactatgtg gactacagac tggaaagaat     3300

caaggaggcc aacaacgaga cctacgtcga gcagcacgag gtggcagtgg ccagatactg     3360

cgacctccct agcaaactgg ggcacaagct taattaaact agttctagag cggccgccac     3420

cgcggtgtcg ataatcaacc tctggattac aaaatttgtg aaagattgac tggtattctt     3480

aactatgttg ctccttttac gctatgtgga tacgctgctt taatgccttt gtatcatgct     3540

attgcttccc gtatggcttt cattttctcc tccttgtata aatcctggtt gctgtctctt     3600

tatgaggagt tgtggcccgt tgtcaggcaa cgtggcgtgg tgtgcactgt gtttgctgac     3660

gcaaccccca ctggttgggg cattgccacc acctgtcagc tcctttccgg gactttcgct     3720

ttccccctcc ctattgccac ggcggaactc atcgccgcct gccttgcccg ctgctggaca     3780

ggggctcggc tgttgggcac tgacaattcc gtggtgttgt cggggaaatc atcgtccttt     3840

ccttggctgc tcgcctgtgt tgccacctgg attctgcgcg ggacgtcctt ctgctacgtc     3900

ccttcggccc tcaatccagc ggaccttcct tcccgcggcc tgctgccggc tctgcggcct     3960

cttccgcgtc ttcgccttcg ccctcagacg agtcggatct ccctttgggc cgcctccccg     4020

cgagctccag cttttgttcc ctttagtgag ggttaattgc gcgcttggcg taatcatggt     4080

catagctgtt tcctgtgtga aattgttatc cgctcacaat tccacacaac atacgagccg     4140

gaagcataaa gtgtaaagcc tggggtgcct aatgagtgag ctaactcaca ttaattgcgt     4200

tgcgctcact gcccgctttc cagtcgggaa acctgtcgtg ccagctgcat taatgaatcg     4260

gccaacgcgc ggggagaggc ggtttgcgta ttgggcgctc ttccgcttcc tcgctcactg     4320

actcgctgcg ctcggtcgtt cggctgcggc gagcggtatc agctcactca aaggcggtaa     4380

tacggttatc cacagaatca ggggataacg caggaaagaa catgtgagca aaaggccagc     4440

aaaaggccag gaaccgtaaa aaggccgcgt tgctggcgtt tttccatagg ctccgccccc     4500

ctgacgagca tcacaaaaat cgacgctcaa gtcagaggtg gcgaaacccg acaggactat     4560

aaagatacca ggcgtttccc cctggaagct ccctcgtgcg ctctcctgtt ccgaccctgc     4620

cgcttaccgg atacctgtcc gcctttctcc cttcgggaag cgtggcgctt tctcatagct     4680

cacgctgtag gtatctcagt tcggtgtagg tcgttcgctc caagctgggc tgtgtgcacg     4740

aaccccccgt tcagcccgac cgctgcgcct tatccggtaa ctatcgtctt gagtccaacc     4800

cggtaagaca cgacttatcg ccactggcag cagccactgg taacaggatt agcagagcga     4860

ggtatgtagg cggtgctaca gagttcttga agtggtggcc taactacggc tacactagaa     4920

ggacagtatt tggtatctgc gctctgctga agccagttac cttcggaaaa agagttggta     4980

gctcttgatc cggcaaacaa accaccgctg gtagcggtgg tttttttgtt tgcaagcagc     5040

agattacgcg cagaaaaaaa ggatctcaag aagatccttt gatcttttct acggggtctg     5100

acgctcagtg gaacgaaaac tcacgttaag ggattttggt catgagatta tcaaaaagga     5160

tcttcaccta gatcctttta aattaaaaat gaagttttaa atcaatctaa agtatatatg     5220

agtaaacttg gtctgacagt taccaatgct taatcagtga ggcacctatc tcagcgatct     5280

gtctatttcg ttcatccata gttgcctgac tccccgtcgt gtagataact acgatacggg     5340

agggcttacc atctggcccc agtgctgcaa tgataccgcg agacccacgc tcaccggctc     5400

cagatttatc agcaataaac cagccagccg gaagggccga gcgcagaagt ggtcctgcaa     5460

ctttatccgc ctccatccag tctattaatt gttgccggga agctagagta agtagttcgc     5520

cagttaatag tttgcgcaac gttgttgcca ttgctacagg catcgtggtg tcacgctcgt     5580

cgtttggtat ggcttcattc agctccggtt cccaacgatc aaggcgagtt acatgatccc     5640

ccatgttgtg caaaaaagcg gttagctcct tcggtcctcc gatcgttgtc agaagtaagt     5700

tggccgcagt gttatcactc atggttatgg cagcactgca taattctctt actgtcatgc     5760

catccgtaag atgcttttct gtgactggtg agtactcaac caagtcattc tgagaatagt     5820

gtatgcggcg accgagttgc tcttgcccgg cgtcaatacg ggataatacc gcgccacata     5880

gcagaacttt aaaagtgctc atcattggaa aacgttcttc ggggcgaaaa ctctcaagga     5940

tcttaccgct gttgagatcc agttcgatgt aacccactcg tgcacccaac tgatcttcag     6000

catcttttac tttcaccagc gtttctgggt gagcaaaaac aggaaggcaa aatgccgcaa     6060

aaaagggaat aagggcgaca cggaaatgtt gaatactcat actcttcctt tttcaatatt     6120

attgaagcat ttatcagggt tattgtctca tgagcggata catatttgaa tgtatttaga     6180

aaaataaaca aataggggtt ccgcgcacat ttccccgaaa agtgccac                  6228


<210>  8
<211>  2827
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Hsyn1:GGEDI-P2a-mApple

<400>  8
ctaaattgta agcgttaata ttttgttaaa attcgcgtta aatttttgtt aaatcagctc       60

attttttaac caataggccg aaatcggcaa aatcccttat aaatcaaaag aatagaccga      120

gatagggttg agtgttgttc cagtttggaa caagagtcca ctattaaaga acgtggactc      180

caacgtcaaa gggcgaaaaa ccgtctatca gggcgatggc ccactacgtg aaccatcacc      240

ctaatcaagt tttttggggt cgaggtgccg taaagcacta aatcggaacc ctaaagggag      300

cccccgattt agagcttgac ggggaaagcc ggcgaacgtg gcgagaaagg aagggaagaa      360

agcgaaagga gcgggcgcta gggcgctggc aagtgtagcg gtcacgctgc gcgtaaccac      420

cacacccgcc gcgcttaatg cgccgctaca gggcgcgtcc cattcgccat tcaggctgcg      480

caactgttgg gaagggcgat cggtgcgggc ctcttcgcta ttacgccagc tggcgaaagg      540

gggatgtgct gcaaggcgat taagttgggt aacgccaggg ttttcccagt cacgacgttg      600

taaaacgacg gccagtgagc gcgcgtaata cgactcacta tagggcgaat tgggtaccgc      660

cgccaccatg ggtgacaatg acatccactt tgcctttctc tccacaggcg cgcactccca      720

ggtccaactg cagggatcca tggtcgactc ttcacgtcgt aagtggaata agacaggtca      780

cgcagtcaga gctataggtc ggctgagctc actcgagaac gtctatatca aggccgacga      840

gcagaagaac ggcatcaagg cgtacttcaa gatccgccac aacatcgagg gcggcggcgt      900

gcagctcgcc taccactacc agcagaacac ccccatcggc gacggccccg tgctgctgcc      960

cgacaaccac tacctgagcg tgcagtccat actttcgaaa gaccccaacg agaagcgcga     1020

tcacatggtc ctgctggagt tcgtgaccgc cgccgggatc actctcggca tggacgagct     1080

gtacaagggc ggtaccggag ggagcatggt gagcaagggc gaggagctgt tcaccggggt     1140

ggtgcccatc caggtcgagc tggacggcga cgtaaacggc cacaagttca gcgtgtccgg     1200

cgagggtgag ggcgatgcca cctacggcaa gctgaccctg aagttcatct gcaccaccgg     1260

caagctgccc gtgccctggc ccaccctcgt gaccaccctg acctacggcg tgcagtgctt     1320

cagccgctac cccgaccaca tgaagcagca cgacttcttc aagtccgcca tgcccgaagg     1380

ctacatccag gagcgcacca tcttcttcaa ggacgacggc aactacaaga cccgcgccga     1440

ggtgaagttc gagggcgaca ccctggtgaa ccgcatcgag ctgaagggca tcgacttcaa     1500

ggaggacggc aacatcctgg ggcacaagct ggagtacaac acgcgtgacc aactgactga     1560

agagcagatc gcagaattta aagaggcttt ctccctattt gacaaggacg gggatgggac     1620

gataacaacc aaggatctgg ggacggtgct gcggtctctg gggcagaacc ccacagaagc     1680

agagctccag gacatgatca atgaagtaga tgccgacggt aatggcacaa tcgacttccc     1740

tgagttcctg acaatgatgg caagaaaaat gaaagacaca gacagtgaag aagaaattcg     1800

cgaagcgttc cgtgtgtggg ataaggatgg caatggctac atctctgcag cagaccttcg     1860

ccacgtgatg acaaaccttg gagagaagtt aacagatgaa gaggttgatg aaatgatcag     1920

ggaagcagat atcgatggag aaggtcaggt aaactacgaa gagtttgtac aaatgatgac     1980

agcgaaggcg gccgcagaac aaaaactcat ctcagaagag gatctgaatg gggccgcaag     2040

cgagggatcc ggatccggag ccacgaactt ctctctgtta aagcaagcag gagacgtgga     2100

agaaaacccc ggtcctatgg tgagcaaggg cgaggagaat aacatggcca tcatcaagga     2160

gttcatgcgc ttcaaggtgc acatggaggg ctccgtgaac ggccacgagt tcgagatcga     2220

gggcgagggc gagggccgcc cctacgaggc ctttcagacc gctaagctga aggtgaccaa     2280

gggtggcccc ctgcccttcg cctgggacat cctgtcccct cagttcatgt acggctccaa     2340

ggtctacatt aagcacccag ccgacatccc cgactacttc aagctgtcct tccccgaggg     2400

cttcaggtgg gagcgcgtga tgaacttcga ggacggcggc attattcacg ttaaccagga     2460

ctcctccctg caggacggcg tgttcatcta caaggtgaag ctgcgcggca ccaacttccc     2520

ctccgacggc cccgtaatgc agaagaagac catgggctgg gaggcctccg aggagcggat     2580

gtaccccgag gacggcgccc tgaagagcga gatcaagaag aggctgaagc tgaaggacgg     2640

cggccactac gccgccgagg tcaagaccac ctacaaggcc aagaagcccg tgcagctgcc     2700

cggcgcctac atcgtcgaca tcaagttgga catcgtgtcc cacaacgagg actacaccat     2760

cgtggaacag tacgaacgcg ccgagggccg ccactccacc ggcggcatgg acgagctgta     2820

caagtaa                                                               2827


<210>  9
<211>  6756
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  pAAV-hSyn1-mRuby2-GSG-P2A-GCaMP6f-WPRE-pA

<400>  9
ctgcagaggg ccctgcgtat gagtgcaagt gggttttagg accaggatga ggcggggtgg       60

gggtgcctac ctgacgaccg accccgaccc actggacaag cacccaaccc ccattcccca      120

aattgcgcat cccctatcag agagggggag gggaaacagg atgcggcgag gcgcgtgcgc      180

actgccagct tcagcaccgc ggacagtgcc ttcgcccccg cctggcggcg cgcgccaccg      240

ccgcctcagc actgaaggcg cgctgacgtc actcgccggt cccccgcaaa ctccccttcc      300

cggccacctt ggtcgcgtcc gcgccgccgc cggcccagcc ggaccgcacc acgcgaggcg      360

cgagataggg gggcacgggc gcgaccatct gcgctgcggc gccggcgact cagcgctgcc      420

tcagtctgcg gtgggcagcg gaggagtcgt gtcgtgcctg agagcgcagt cgaattcaag      480

ctgctagcaa ggatccaccc gccacctacc ggtcctaggg ccaccatggt gtctaagggc      540

gaagagctga tcaaggaaaa tatgcgtatg aaggtggtca tggaaggttc ggtcaacggc      600

caccaattca aatgcacagg tgaaggagaa ggcaatccgt acatgggaac tcaaaccatg      660

aggatcaaag tcatcgaggg aggacccctg ccatttgcct ttgacattct tgccacgtcg      720

ttcatgtatg gcagccgtac ttttatcaag tacccgaaag gcattcctga tttctttaaa      780

cagtcctttc ctgagggttt tacttgggaa agagttacga gatacgaaga tggtggagtc      840

gtcaccgtca tgcaggacac cagccttgag gatggctgtc tcgtttacca cgtccaagtc      900

agaggggtaa actttccctc caatggtccc gtgatgcaga agaagaccaa gggttgggag      960

cctaatacag agatgatgta tccagcagat ggtggtctga ggggatacac tcatatggca     1020

ctgaaagttg atggtggtgg ccatctgtct tgctctttcg taacaactta caggtcaaaa     1080

aagaccgtcg ggaacatcaa gatgcccggt atccatgccg ttgatcaccg cctggaaagg     1140

ttagaggaaa gtgacaatga aatgttcgta gtacaacgcg aacacgcagt tgccaagttc     1200

gccgggcttg gtggtgggat ggacgagctg tacaagggat ccggagccac gaacttctct     1260

ctgttaaagc aagcaggaga cgtggaagaa aaccccggtc ctggttctca tcatcatcat     1320

catcatggta tggctagcat gactggtgga cagcaaatgg gtcgggatct gtacgacgat     1380

gacgataagg atctcgccac catggtcgac tcatcacgtc gtaagtggaa taagacaggt     1440

cacgcagtca gagctatagg tcggctgagc tcactcgaga acgtctatat caaggccgac     1500

aagcagaaga acggcatcaa ggcgaacttc aagatccgcc acaacatcga ggacggcggc     1560

gtgcagctcg cctaccacta ccagcagaac acccccatcg gcgacggccc cgtgctgctg     1620

cccgacaacc actacctgag cgtgcagtcc aaactttcga aagaccccaa cgagaagcgc     1680

gatcacatgg tcctgctgga gttcgtgacc gccgccggga tcactctcgg catggacgag     1740

ctgtacaagg gcggtaccgg agggagcatg gtgagcaagg gcgaggagct gttcaccggg     1800

gtggtgccca tcctggtcga gctggacggc gacgtaaacg gccacaagtt cagcgtgtcc     1860

ggcgagggtg agggcgatgc cacctacggc aagctgaccc tgaagttcat ctgcaccacc     1920

ggcaagctgc ccgtgccctg gcccaccctc gtgaccaccc tgacctacgg cgtgcagtgc     1980

ttcagccgct accccgacca catgaagcag cacgacttct tcaagtccgc catgcccgaa     2040

ggctacatcc aggagcgcac catcttcttc aaggacgacg gcaactacaa gacccgcgcc     2100

gaggtgaagt tcgagggcga caccctggtg aaccgcatcg agctgaaggg catcgacttc     2160

aaggaggacg gcaacatcct ggggcacaag ctggagtaca acctgccgga ccaactgact     2220

gaagagcaga tcgcagaatt taaagaggaa ttctccctat ttgacaagga cggggatggg     2280

acaataacaa ccaaggagct ggggacggtg atgcggtctc tggggcagaa ccccacagaa     2340

gcagagctgc aggacatgat caatgaagta gatgccgacg gtgacggcac aatcgacttc     2400

cctgagttcc tgacaatgat ggcaagaaaa atgaaataca gggacacgga agaagaaatt     2460

agagaagcgt tcggtgtgtt tgataaggat ggcaatggct acatcagtgc agcagagctt     2520

cgccacgtga tgacaaacct tggagagaag ttaacagatg aagaggttga tgaaatgatc     2580

agggaagcag acatcgatgg ggatggtcag gtaaactacg aagagtttgt acaaatgatg     2640

acagcgaagt aagcggccgc actagctagt gcggccgctt atgaaagcta tcgataatca     2700

acctctggat tacaaaattt gtgaaagatt gactggtatt cttaactatg ttgctccttt     2760

tacgctatgt ggatacgctg ctttaatgcc tttgtatcat gctattgctt cccgtatggc     2820

tttcattttc tcctccttgt ataaatcctg gttgctgtct ctttatgagg agttgtggcc     2880

cgttgtcagg caacgtggcg tggtgtgcac tgtgtttgct gacgcaaccc ccactggttg     2940

gggcattgcc accacctgtc agctcctttc cgggactttc gctttccccc tccctattgc     3000

cacggcggaa ctcatcgccg cctgccttgc ccgctgctgg acaggggctc ggctgttggg     3060

cactgacaat tccgtggtgt tgtcggggaa atcatcgtcc tttccttggc tgctcgcctg     3120

tgttgccacc tggattctgc gcgggacgtc cttctgctac gtcccttcgg ccctcaatcc     3180

agcggacctt ccttcccgcg gcctgctgcc ggctctgcgg cctcttccgc gtcttcgcct     3240

tcgccctcag acgagtcgga tctccctttg ggccgcctcc ccgcatcgat accgtcgacc     3300

tcgacccggg cggccgcttc gagcagacat gataagatac attgatgagt ttggacaaac     3360

cacaactaga atgcagtgaa aaaaatgctt tatttgtgaa atttgtgatg ctattgcttt     3420

atttgtaacc attataagct gcaataaaca agttaacaac aacaattgca ttcattttat     3480

gtttcaggtt cagggggaga tgtgggaggt tttttaaagc aagtaaaacc tctacaaatg     3540

tggtaaaatc gataaggatc ttcctagagc atggctacgt agataagtag catggcgggt     3600

taatcattaa ctacaaggaa cccctagtga tggagttggc cactccctct ctgcgcgctc     3660

gctcgctcac tgaggccggg cgaccaaagg tcgcccgacg cccgggcttt gcccgggcgg     3720

cctcagtgag cgagcgagcg cgcagcctta attaacctaa ttcactggcc gtcgttttac     3780

aacgtcgtga ctgggaaaac cctggcgtta cccaacttaa tcgccttgca gcacatcccc     3840

ctttcgccag ctggcgtaat agcgaagagg cccgcaccga tcgcccttcc caacagttgc     3900

gcagcctgaa tggcgaatgg gacgcgccct gtagcggcgc attaagcgcg gcgggtgtgg     3960

tggttacgcg cagcgtgacc gctacacttg ccagcgccct agcgcccgct cctttcgctt     4020

tcttcccttc ctttctcgcc acgttcgccg gctttccccg tcaagctcta aatcgggggc     4080

tccctttagg gttccgattt agtgctttac ggcacctcga ccccaaaaaa cttgattagg     4140

gtgatggttc acgtagtggg ccatcgccct gatagacggt ttttcgccct ttgacgttgg     4200

agtccacgtt ctttaatagt ggactcttgt tccaaactgg aacaacactc aaccctatct     4260

cggtctattc ttttgattta taagggattt tgccgatttc ggcctattgg ttaaaaaatg     4320

agctgattta acaaaaattt aacgcgaatt ttaacaaaat attaacgctt acaatttagg     4380

tggcactttt cggggaaatg tgcgcggaac ccctatttgt ttatttttct aaatacattc     4440

aaatatgtat ccgctcatga gacaataacc ctgataaatg cttcaataat attgaaaaag     4500

gaagagtatg agtattcaac atttccgtgt cgcccttatt cccttttttg cggcattttg     4560

ccttcctgtt tttgctcacc cagaaacgct ggtgaaagta aaagatgctg aagatcagtt     4620

gggtgcacga gtgggttaca tcgaactgga tctcaacagc ggtaagatcc ttgagagttt     4680

tcgccccgaa gaacgttttc caatgatgag cacttttaaa gttctgctat gtggcgcggt     4740

attatcccgt attgacgccg ggcaagagca actcggtcgc cgcatacact attctcagaa     4800

tgacttggtt gagtactcac cagtcacaga aaagcatctt acggatggca tgacagtaag     4860

agaattatgc agtgctgcca taaccatgag tgataacact gcggccaact tacttctgac     4920

aacgatcgga ggaccgaagg agctaaccgc ttttttgcac aacatggggg atcatgtaac     4980

tcgccttgat cgttgggaac cggagctgaa tgaagccata ccaaacgacg agcgtgacac     5040

cacgatgcct gtagcaatgg caacaacgtt gcgcaaacta ttaactggcg aactacttac     5100

tctagcttcc cggcaacaat taatagactg gatggaggcg gataaagttg caggaccact     5160

tctgcgctcg gcccttccgg ctggctggtt tattgctgat aaatctggag ccggtgagcg     5220

tgggtctcgc ggtatcattg cagcactggg gccagatggt aagccctccc gtatcgtagt     5280

tatctacacg acggggagtc aggcaactat ggatgaacga aatagacaga tcgctgagat     5340

aggtgcctca ctgattaagc attggtaact gtcagaccaa gtttactcat atatacttta     5400

gattgattta aaacttcatt tttaatttaa aaggatctag gtgaagatcc tttttgataa     5460

tctcatgacc aaaatccctt aacgtgagtt ttcgttccac tgagcgtcag accccgtaga     5520

aaagatcaaa ggatcttctt gagatccttt ttttctgcgc gtaatctgct gcttgcaaac     5580

aaaaaaacca ccgctaccag cggtggtttg tttgccggat caagagctac caactctttt     5640

tccgaaggta actggcttca gcagagcgca gataccaaat actgttcttc tagtgtagcc     5700

gtagttaggc caccacttca agaactctgt agcaccgcct acatacctcg ctctgctaat     5760

cctgttacca gtggctgctg ccagtggcga taagtcgtgt cttaccgggt tggactcaag     5820

acgatagtta ccggataagg cgcagcggtc gggctgaacg gggggttcgt gcacacagcc     5880

cagcttggag cgaacgacct acaccgaact gagataccta cagcgtgagc tatgagaaag     5940

cgccacgctt cccgaaggga gaaaggcgga caggtatccg gtaagcggca gggtcggaac     6000

aggagagcgc acgagggagc ttccaggggg aaacgcctgg tatctttata gtcctgtcgg     6060

gtttcgccac ctctgacttg agcgtcgatt tttgtgatgc tcgtcagggg ggcggagcct     6120

atggaaaaac gccagcaacg cggccttttt acggttcctg gccttttgct ggccttttgc     6180

tcacatgttc tttcctgcgt tatcccctga ttctgtggat aaccgtatta ccgcctttga     6240

gtgagctgat accgctcgcc gcagccgaac gaccgagcgc agcgagtcag tgagcgagga     6300

agcggaagag cgcccaatac gcaaaccgcc tctccccgcg cgttggccga ttcattaatg     6360

cagctggcac gacaggtttc ccgactggaa agcgggcagt gagcgcaacg caattaatgt     6420

gagttagctc actcattagg caccccaggc tttacacttt atgcttccgg ctcgtatgtt     6480

gtgtggaatt gtgagcggat aacaatttca cacaggaaac agctatgacc atgattacgc     6540

cagatttaat taaggcctta attaggctgc gcgctcgctc gctcactgag gccgcccggg     6600

caaagcccgg gcgtcgggcg acctttggtc gcccggcctc agtgagcgag cgagcgcgca     6660

gagagggagt ggccaactcc atcactaggg gttccttgta gttaatgatt aacccgccat     6720

gctacttatc tacgtagcca tgctctagga agatct                               6756


<210>  10
<211>  4324
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Hsyn1:RGEDI-P2a-3xTagBFP2

<400>  10
ctaaattgta agcgttaata ttttgttaaa attcgcgtta aatttttgtt aaatcagctc       60

attttttaac caataggccg aaatcggcaa aatcccttat aaatcaaaag aatagaccga      120

gatagggttg agtgttgttc cagtttggaa caagagtcca ctattaaaga acgtggactc      180

caacgtcaaa gggcgaaaaa ccgtctatca gggcgatggc ccactacgtg aaccatcacc      240

ctaatcaagt tttttggggt cgaggtgccg taaagcacta aatcggaacc ctaaagggag      300

cccccgattt agagcttgac ggggaaagcc ggcgaacgtg gcgagaaagg aagggaagaa      360

agcgaaagga gcgggcgcta gggcgctggc aagtgtagcg gtcacgctgc gcgtaaccac      420

cacacccgcc gcgcttaatg cgccgctaca gggcgcgtcc cattcgccat tcaggctgcg      480

caactgttgg gaagggcgat cggtgcgggc ctcttcgcta ttacgccagc tggcgaaagg      540

gggatgtgct gcaaggcgat taagttgggt aacgccaggg ttttcccagt cacgacgttg      600

taaaacgacg gccagtgagc gcgcgtaata cgactcacta tagggcgaat tgggtaccaa      660

gcttgccgcc accatgggtg acaatgacat ccactttgcc tttctctcca caggcgcgca      720

ctcccaggtc caactgcagg gatccatggt cgactcttca cgtcgtaagt ggaataaggc      780

aggtcacgca gtcagagcta taggtcggct gagctcaccc gtggtttccg agcggatgta      840

ccccgaggac ggcgccctga agagcgagat caagaagggg ctgaggctga aggacggcgg      900

ccactacgcc gccgaggtca agaccaccta caaggccaag aagcccgtgc agctgcccgg      960

cgcctacatc gtcgacatca agttggacat cgtgtcccac aacgaggact acaccatcgt     1020

ggaacagtgc gaacgcgccg agggccgcca ctccaccggc ggcatggacg agctgtacaa     1080

gggaggtaca ggcgggagtc tggtgagcaa gggcgaggag gataacatgg ccatcatcaa     1140

ggagttcatg cgcttcaagg tgcacatgga gggctccgtg aacggccacg agttcgagat     1200

cgagggcgag ggcgagggcc gcccctacga ggcctttcag accgctaagc tgaaggtgac     1260

caagggtggc cccctgccct tcgcctggga catcctgtcc cctcagttca tgtacggctc     1320

caaggcctac attaagcacc cagccgacat ccccgactac ttcaagctgt ccttccccga     1380

gggcttcagg tgggagcgcg tgatgaactt cgaggacggc ggcattattc acgttaacca     1440

ggactcctcc ctgcaggacg gcgtattcat ctacaaggtg aagctgcgcg gcaccaactt     1500

cccccccgac ggccccgtaa tgcagaagaa gaccatgggc tgggaggcta ctcgagacca     1560

actgactgaa gagcagatcg cagaatttaa agaggctttc tccctatttg acaaggacgg     1620

ggatgggaca ataacaacca aggatctggg gacggtgctg cggtctctgg ggcagaaccc     1680

cacagaagca gagctccagg acatgatcaa tgaagtagat gccgacggta atggcacaat     1740

cgacttccct gatttcctga caatgatggc aagaaaaatg aaagacacag acagtgaaga     1800

agaaattcgc gaagcgttcc gtgtgtggga taaggatggc aatggctaca tctctgcagc     1860

agaccttcgc cacgtgatga caaaccttgg agagaagtta acagatgaag aggttgatga     1920

aatgatcagg gaagcagata tcgatggaga aggtcaggta aactacgaag agtttgtaca     1980

aatgatgaca gcgaaggcgg ccgcagaaca aaaactcatc tcagaagagg atctgaatgg     2040

ggccgcaagc gagggatccg gatccggagc cacgaacttc tctctgttaa agcaagcagg     2100

agacgtggaa gaaaaccccg gtcctgggag ccaccatcac catcaccatg gcagatctat     2160

gagcgagctg attaaggaga acatgcacat gaagctgtac atggagggca ccgtggacaa     2220

ccatcacttc aagtgcacat ccgagggcga aggcaagccc tacgagggca cccagaccat     2280

gagaatcaag gtggtcgagg gcggccctct ccccttcgcc ttcgacatcc tggctactag     2340

cttcctctac ggcagcaaga ccttcatcaa ccacacccag ggcatccccg acttcttcaa     2400

gcagtccttc cctgagggct tcacatggga gagagtcacc acatacgaag acgggggcgt     2460

gctgaccgct acccaggaca ccagcctcca ggacggctgc ctcatctaca acgtcaagat     2520

cagaggggtg aacttcacat ccaacggccc tgtgatgcag aagaaaacac tcggctggga     2580

ggccttcacc gagacgctgt accccgctga cggcggcctg gaaggcagaa acgacatggc     2640

cctgaagctc gtgggcggga gccatctgat cgcaaacgcc aagaccacat atagatccaa     2700

gaaacccgct aagaacctca agatgcctgg cgtctactat gtggactaca gactggaaag     2760

aatcaaggag gccaacaacg agacctacgt cgagcagcac gaggtggcag tggccagata     2820

ctgcgacctc cctagcaaac tggggcacaa gcttaatggg agccaccatc accatcacca     2880

tggcagatct atgagcgagc tgattaagga gaacatgcac atgaagctgt acatggaggg     2940

caccgtggac aaccatcact tcaagtgcac atccgagggc gaaggcaagc cctacgaggg     3000

cacccagacc atgagaatca aggtggtcga gggcggccct ctccccttcg ccttcgacat     3060

cctggctact agcttcctct acggcagcaa gaccttcatc aaccacaccc agggcatccc     3120

cgacttcttc aagcagtcct tccctgaggg cttcacatgg gagagagtca ccacatacga     3180

agacgggggc gtgctgaccg ctacccagga caccagcctc caggacggct gcctcatcta     3240

caacgtcaag atcagagggg tgaacttcac atccaacggc cctgtgatgc agaagaaaac     3300

actcggctgg gaggccttca ccgagacgct gtaccccgct gacggcggcc tggaaggcag     3360

aaacgacatg gccctgaagc tcgtgggcgg gagccatctg atcgcaaacg ccaagaccac     3420

atatagatcc aagaaacccg ctaagaacct caagatgcct ggcgtctact atgtggacta     3480

cagactggaa agaatcaagg aggccaacaa cgagacctac gtcgagcagc acgaggtggc     3540

agtggccaga tactgcgacc tccctagcaa actggggcac aagcttaatg ggagccacca     3600

tcaccatcac catggcagat ctatgagcga gctgattaag gagaacatgc acatgaagct     3660

gtacatggag ggcaccgtgg acaaccatca cttcaagtgc acatccgagg gcgaaggcaa     3720

gccctacgag ggcacccaga ccatgagaat caaggtggtc gagggcggcc ctctcccctt     3780

cgccttcgac atcctggcta ctagcttcct ctacggcagc aagaccttca tcaaccacac     3840

ccagggcatc cccgacttct tcaagcagtc cttccctgag ggcttcacat gggagagagt     3900

caccacatac gaagacgggg gcgtgctgac cgctacccag gacaccagcc tccaggacgg     3960

ctgcctcatc tacaacgtca agatcagagg ggtgaacttc acatccaacg gccctgtgat     4020

gcagaagaaa acactcggct gggaggcctt caccgagacg ctgtaccccg ctgacggcgg     4080

cctggaaggc agaaacgaca tggccctgaa gctcgtgggc gggagccatc tgatcgcaaa     4140

cgccaagacc acatatagat ccaagaaacc cgctaagaac ctcaagatgc ctggcgtcta     4200

ctatgtggac tacagactgg aaagaatcaa ggaggccaac aacgagacct acgtcgagca     4260

gcacgaggtg gcagtggcca gatactgcga cctccctagc aaactggggc acaagcttaa     4320

ttaa                                                                  4324


<210>  11
<211>  2881
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Hsyn1:RGEDInls-P2a-EGFPnls

<400>  11
ctaaattgta agcgttaata ttttgttaaa attcgcgtta aatttttgtt aaatcagctc       60

attttttaac caataggccg aaatcggcaa aatcccttat aaatcaaaag aatagaccga      120

gatagggttg agtgttgttc cagtttggaa caagagtcca ctattaaaga acgtggactc      180

caacgtcaaa gggcgaaaaa ccgtctatca gggcgatggc ccactacgtg aaccatcacc      240

ctaatcaagt tttttggggt cgaggtgccg taaagcacta aatcggaacc ctaaagggag      300

cccccgattt agagcttgac ggggaaagcc ggcgaacgtg gcgagaaagg aagggaagaa      360

agcgaaagga gcgggcgcta gggcgctggc aagtgtagcg gtcacgctgc gcgtaaccac      420

cacacccgcc gcgcttaatg cgccgctaca gggcgcgtcc cattcgccat tcaggctgcg      480

caactgttgg gaagggcgat cggtgcgggc ctcttcgcta ttacgccagc tggcgaaagg      540

gggatgtgct gcaaggcgat taagttgggt aacgccaggg ttttcccagt cacgacgttg      600

taaaacgacg gccagtgagc gcgcgtaata cgactcacta tagggcgaat tgggtaccaa      660

gcttgccgcc accatgggtg acaatgacat ccactttgcc tttctctcca caggcgcgca      720

ctcccaggtc caactgcagg gatccatggt cgactcttca cgtcgtaagt ggaataaggc      780

aggtcacgca gtcagagcta taggtcggct gagctcaccc gtggtttccg agcggatgta      840

ccccgaggac ggcgccctga agagcgagat caagaagggg ctgaggctga aggacggcgg      900

ccactacgcc gccgaggtca agaccaccta caaggccaag aagcccgtgc agctgcccgg      960

cgcctacatc gtcgacatca agttggacat cgtgtcccac aacgaggact acaccatcgt     1020

ggaacagtgc gaacgcgccg agggccgcca ctccaccggc ggcatggacg agctgtacaa     1080

gggaggtaca ggcgggagtc tggtgagcaa gggcgaggag gataacatgg ccatcatcaa     1140

ggagttcatg cgcttcaagg tgcacatgga gggctccgtg aacggccacg agttcgagat     1200

cgagggcgag ggcgagggcc gcccctacga ggcctttcag accgctaagc tgaaggtgac     1260

caagggtggc cccctgccct tcgcctggga catcctgtcc cctcagttca tgtacggctc     1320

caaggcctac attaagcacc cagccgacat ccccgactac ttcaagctgt ccttccccga     1380

gggcttcagg tgggagcgcg tgatgaactt cgaggacggc ggcattattc acgttaacca     1440

ggactcctcc ctgcaggacg gcgtattcat ctacaaggtg aagctgcgcg gcaccaactt     1500

cccccccgac ggccccgtaa tgcagaagaa gaccatgggc tgggaggcta ctcgagacca     1560

actgactgaa gagcagatcg cagaatttaa agaggctttc tccctatttg acaaggacgg     1620

ggatgggaca ataacaacca aggatctggg gacggtgctg cggtctctgg ggcagaaccc     1680

cacagaagca gagctccagg acatgatcaa tgaagtagat gccgacggta atggcacaat     1740

cgacttccct gatttcctga caatgatggc aagaaaaatg aaagacacag acagtgaaga     1800

agaaattcgc gaagcgttcc gtgtgtggga taaggatggc aatggctaca tctctgcagc     1860

agaccttcgc cacgtgatga caaaccttgg agagaagtta acagatgaag aggttgatga     1920

aatgatcagg gaagcagata tcgatggaga aggtcaggta aactacgaag agtttgtaca     1980

aatgatgaca gcgaaggcgg ccgcagaaca aaaactcatc tcagaagagg atctgaatgg     2040

ggccgcaagc gagcaccttc ctcttcttgg atccggatcc ggagccacga acttctctct     2100

gttaaagcaa gcaggagacg tggaagaaaa ccccggtcct atggtgagca agggcgagga     2160

gctgttcacc ggggtggtgc ccatcctggt cgagctggac ggcgacgtaa acggccacaa     2220

gttcagcgtg tccggcgagg gcgagggcga tgccacctac ggcaagctga ccctgaagtt     2280

catctgcacc accggcaagc tgcccgtgcc ctggcccacc ctcgtgacca ccctgaccta     2340

cggcgtgcag tgcttcagcc gctaccccga ccacatgaag cagcacgact tcttcaagtc     2400

cgccatgccc gaaggctacg tccaggagcg caccatcttc ttcaaggacg acggcaacta     2460

caagacccgc gccgaggtga agttcgaggg cgacaccctg gtgaaccgca tcgagctgaa     2520

gggcatcgac ttcaaggagg acggcaacat cctggggcac aagctggagt acaactacaa     2580

cagccacaac gtctatatca tggccgacaa gcagaagaac ggcatcaagg tgaacttcaa     2640

gatccgccac aacatcgagg acggcagcgt gcagctcgcc gaccactacc agcagaacac     2700

ccccatcggc gacggccccg tgctgctgcc cgacaaccac tacctgagca cccagtccgc     2760

cctgagcaaa gaccccaacg agaagcgcga tcacatggtc ctgctggagt tcgtgaccgc     2820

cgccgggatc actctcggca tggacgagct gtacaagcac cttcctcttc tttaaactag     2880

t                                                                     2881


<210>  12
<211>  6876
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Hsyn1:GGEDI-P2a-jRCAMP1a

<400>  12
ctaaattgta agcgttaata ttttgttaaa attcgcgtta aatttttgtt aaatcagctc       60

attttttaac caataggccg aaatcggcaa aatcccttat aaatcaaaag aatagaccga      120

gatagggttg agtgttgttc cagtttggaa caagagtcca ctattaaaga acgtggactc      180

caacgtcaaa gggcgaaaaa ccgtctatca gggcgatggc ccactacgtg aaccatcacc      240

ctaatcaagt tttttggggt cgaggtgccg taaagcacta aatcggaacc ctaaagggag      300

cccccgattt agagcttgac ggggaaagcc ggcgaacgtg gcgagaaagg aagggaagaa      360

agcgaaagga gcgggcgcta gggcgctggc aagtgtagcg gtcacgctgc gcgtaaccac      420

cacacccgcc gcgcttaatg cgccgctaca gggcgcgtcc cattcgccat tcaggctgcg      480

caactgttgg gaagggcgat cggtgcgggc ctcttcgcta ttacgccagc tggcgaaagg      540

gggatgtgct gcaaggcgat taagttgggt aacgccaggg ttttcccagt cacgacgttg      600

taaaacgacg gccagtgagc gcgcgtaata cgactcacta tagggcgaat tgggtaccgg      660

gctgcagagg gccctgcgta tgagtgcaag tgggttttag gaccaggatg aggcggggtg      720

ggggtgccta cctgacgacc gaccccgacc cactggacaa gcacccaacc cccattcccc      780

aaattgcgca tcccctatca gagaggggga ggggaaacag gatgcggcga ggcgcgtgcg      840

cactgccagc ttcagcaccg cggacagtgc cttcgccccc gcctggcggc gcgcgccacc      900

gccgcctcag cactgaaggc gcgctgacgt cactcgccgg tcccccgcaa actccccttc      960

ccggccacct tggtcgcgtc cgcgccgccg ccggcccagc cggaccgcac cacgcgaggc     1020

gcgagatagg ggggcacggg cgcgaccatc tgcgctgcgg cgccggcgac tcagcgctgc     1080

ctcagtctgc ggtgggcagc ggaggagtcg tgtcgtgcct gagagcgcag tcgaattcaa     1140

gctgctagct agtaccggtc ctagggcccc ccccctcgag gtcgacggta tcgataagct     1200

tgccgccacc atgggtgaca atgacatcca ctttgccttt ctctccacag gcgcgcactc     1260

ccaggtccaa ctgcagggat ccatggtcga ctcttcacgt cgtaagtgga ataagacagg     1320

tcacgcagtc agagctatag gtcggctgag ctcactcgag aacgtctata tcaaggccga     1380

cgagcagaag aacggcatca aggcgtactt caagatccgc cacaacatcg agggcggcgg     1440

cgtgcagctc gcctaccact accagcagaa cacccccatc ggcgacggcc ccgtgctgct     1500

gcccgacaac cactacctga gcgtgcagtc catactttcg aaagacccca acgagaagcg     1560

cgatcacatg gtcctgctgg agttcgtgac cgccgccggg atcactctcg gcatggacga     1620

gctgtacaag ggcggtaccg gagggagcat ggtgagcaag ggcgaggagc tgttcaccgg     1680

ggtggtgccc atccaggtcg agctggacgg cgacgtaaac ggccacaagt tcagcgtgtc     1740

cggcgagggt gagggcgatg ccacctacgg caagctgacc ctgaagttca tctgcaccac     1800

cggcaagctg cccgtgccct ggcccaccct cgtgaccacc ctgacctacg gcgtgcagtg     1860

cttcagccgc taccccgacc acatgaagca gcacgacttc ttcaagtccg ccatgcccga     1920

aggctacatc caggagcgca ccatcttctt caaggacgac ggcaactaca agacccgcgc     1980

cgaggtgaag ttcgagggcg acaccctggt gaaccgcatc gagctgaagg gcatcgactt     2040

caaggaggac ggcaacatcc tggggcacaa gctggagtac aacacgcgtg accaactgac     2100

tgaagagcag atcgcagaat ttaaagaggc tttctcccta tttgacaagg acggggatgg     2160

gacgataaca accaaggatc tggggacggt gctgcggtct ctggggcaga accccacaga     2220

agcagagctc caggacatga tcaatgaagt agatgccgac ggtaatggca caatcgactt     2280

ccctgagttc ctgacaatga tggcaagaaa aatgaaagac acagacagtg aagaagaaat     2340

tcgcgaagcg ttccgtgtgt gggataagga tggcaatggc tacatctctg cagcagacct     2400

tcgccacgtg atgacaaacc ttggagagaa gttaacagat gaagaggttg atgaaatgat     2460

cagggaagca gatatcgatg gagaaggtca ggtaaactac gaagagtttg tacaaatgat     2520

gacagcgaag gcggccgcag aacaaaaact catctcagaa gaggatctga atggggccgc     2580

aagcgaggga tccggatccg gagccacgaa cttctctctg ttaaagcaag caggagacgt     2640

ggaagaaaac cccggtccta tgctgcagaa cgagcttgct cttaagttgg ctggacttga     2700

tattaacaag actggaggag gttctcatca tcatcatcat catggtatgg ctagcatgac     2760

tggtggacag caaatgggtc gggatctgta cgacgatgac gataaggatc tcgcaacaat     2820

ggtcgactca tcacgtcgta agtggaataa gacaggtcac gcagtcagag ctataggtcg     2880

gctgagctca gcgatcaact gcgaaatgat gtacccagcg gatggtggtc tgcgtggtta     2940

cactcacatg gcgctgaaag ttgatggcgg cggtcacctg tcctgttctt tcgtgaccac     3000

ctaccgctcc aaaaagactg tcggcaacat taagatgcct gccattcata gcgtcagcca     3060

ccgtctggag cgcctggagg agagcgataa cgaaatgttt gtcgtacagc gtgaacacgc     3120

agttgccaag tttgtgggcc tgggtggtgg cggcggtacc ggagggagca tgaactccct     3180

gatcaaggag aacatgcgta tgaaagtggt tctggaaggc tccgtaaacg gccaccagtt     3240

caaatgcact ggtgaaggcg aaggcaaccc gtatatgggc acccagacta tgcgtatcaa     3300

agtgatcgag ggtggtccgc tgccgtttgc gttcgacatc ctggcgacgt cctttatgta     3360

tggctcccgt accttcatca aatatccgaa aggcatcccg gatttcttta agcagtcctt     3420

cccggaaggt tttacctggg aacgtgtgac ccgttacgaa gacggcggcg taattaccgt     3480

tatgcaagac acgtctctgg aggatggctg cctggtgtat cacgtgcagg ttcgcggtgt     3540

gaacttcccg agcaatggtg ctgtaatgca aaagaaaacc aaaggttggg agcctacgga     3600

ctcccaaacc actgaagagc agatcgcaga atttaaagag gctttctccc tatttgacaa     3660

ggacggggat gggacaataa caaccaagga gctggggacg gtgatgcggt ctctggggca     3720

gaaccccaca gaagcagagc tgcaggacat gatcaatgaa gtagatgccg acggtgacgg     3780

cacaatcgac ttccctgagt tcctgattat gatggcaaga aaaatgaaat acacagacag     3840

tgaagaagaa attagagaag cgttcggcgt gtttgataag gatggcaatg gctacatcag     3900

tgcagcagag cttcgccacg tgatgacaaa ccttggagag aagttaacag atgaagaggt     3960

tgatgaaatg atcagggaag cagacagcga tggggatggt caggtaaact acgaagagtt     4020

tgtacaaatg atgacagcga agtagactag ttctagagcg gccgccaccg cggtgtcgat     4080

aatcaacctc tggattacaa aatttgtgaa agattgactg gtattcttaa ctatgttgct     4140

ccttttacgc tatgtggata cgctgcttta atgcctttgt atcatgctat tgcttcccgt     4200

atggctttca ttttctcctc cttgtataaa tcctggttgc tgtctcttta tgaggagttg     4260

tggcccgttg tcaggcaacg tggcgtggtg tgcactgtgt ttgctgacgc aacccccact     4320

ggttggggca ttgccaccac ctgtcagctc ctttccggga ctttcgcttt ccccctccct     4380

attgccacgg cggaactcat cgccgcctgc cttgcccgct gctggacagg ggctcggctg     4440

ttgggcactg acaattccgt ggtgttgtcg gggaaatcat cgtcctttcc ttggctgctc     4500

gcctgtgttg ccacctggat tctgcgcggg acgtccttct gctacgtccc ttcggccctc     4560

aatccagcgg accttccttc ccgcggcctg ctgccggctc tgcggcctct tccgcgtctt     4620

cgccttcgcc ctcagacgag tcggatctcc ctttgggccg cctccccgcg agctccagct     4680

tttgttccct ttagtgaggg ttaattgcgc gcttggcgta atcatggtca tagctgtttc     4740

ctgtgtgaaa ttgttatccg ctcacaattc cacacaacat acgagccgga agcataaagt     4800

gtaaagcctg gggtgcctaa tgagtgagct aactcacatt aattgcgttg cgctcactgc     4860

ccgctttcca gtcgggaaac ctgtcgtgcc agctgcatta atgaatcggc caacgcgcgg     4920

ggagaggcgg tttgcgtatt gggcgctctt ccgcttcctc gctcactgac tcgctgcgct     4980

cggtcgttcg gctgcggcga gcggtatcag ctcactcaaa ggcggtaata cggttatcca     5040

cagaatcagg ggataacgca ggaaagaaca tgtgagcaaa aggccagcaa aaggccagga     5100

accgtaaaaa ggccgcgttg ctggcgtttt tccataggct ccgcccccct gacgagcatc     5160

acaaaaatcg acgctcaagt cagaggtggc gaaacccgac aggactataa agataccagg     5220

cgtttccccc tggaagctcc ctcgtgcgct ctcctgttcc gaccctgccg cttaccggat     5280

acctgtccgc ctttctccct tcgggaagcg tggcgctttc tcatagctca cgctgtaggt     5340

atctcagttc ggtgtaggtc gttcgctcca agctgggctg tgtgcacgaa ccccccgttc     5400

agcccgaccg ctgcgcctta tccggtaact atcgtcttga gtccaacccg gtaagacacg     5460

acttatcgcc actggcagca gccactggta acaggattag cagagcgagg tatgtaggcg     5520

gtgctacaga gttcttgaag tggtggccta actacggcta cactagaagg acagtatttg     5580

gtatctgcgc tctgctgaag ccagttacct tcggaaaaag agttggtagc tcttgatccg     5640

gcaaacaaac caccgctggt agcggtggtt tttttgtttg caagcagcag attacgcgca     5700

gaaaaaaagg atctcaagaa gatcctttga tcttttctac ggggtctgac gctcagtgga     5760

acgaaaactc acgttaaggg attttggtca tgagattatc aaaaaggatc ttcacctaga     5820

tccttttaaa ttaaaaatga agttttaaat caatctaaag tatatatgag taaacttggt     5880

ctgacagtta ccaatgctta atcagtgagg cacctatctc agcgatctgt ctatttcgtt     5940

catccatagt tgcctgactc cccgtcgtgt agataactac gatacgggag ggcttaccat     6000

ctggccccag tgctgcaatg ataccgcgag acccacgctc accggctcca gatttatcag     6060

caataaacca gccagccgga agggccgagc gcagaagtgg tcctgcaact ttatccgcct     6120

ccatccagtc tattaattgt tgccgggaag ctagagtaag tagttcgcca gttaatagtt     6180

tgcgcaacgt tgttgccatt gctacaggca tcgtggtgtc acgctcgtcg tttggtatgg     6240

cttcattcag ctccggttcc caacgatcaa ggcgagttac atgatccccc atgttgtgca     6300

aaaaagcggt tagctccttc ggtcctccga tcgttgtcag aagtaagttg gccgcagtgt     6360

tatcactcat ggttatggca gcactgcata attctcttac tgtcatgcca tccgtaagat     6420

gcttttctgt gactggtgag tactcaacca agtcattctg agaatagtgt atgcggcgac     6480

cgagttgctc ttgcccggcg tcaatacggg ataataccgc gccacatagc agaactttaa     6540

aagtgctcat cattggaaaa cgttcttcgg ggcgaaaact ctcaaggatc ttaccgctgt     6600

tgagatccag ttcgatgtaa cccactcgtg cacccaactg atcttcagca tcttttactt     6660

tcaccagcgt ttctgggtga gcaaaaacag gaaggcaaaa tgccgcaaaa aagggaataa     6720

gggcgacacg gaaatgttga atactcatac tcttcctttt tcaatattat tgaagcattt     6780

atcagggtta ttgtctcatg agcggataca tatttgaatg tatttagaaa aataaacaaa     6840

taggggttcc gcgcacattt ccccgaaaag tgccac                               6876


