                         SEQUENCE LISTING

<110>  Flynn, Jessica Anne
       Babaoglu, Kerim
       Fridman, Arthur
       Nickle, David
       Zhang, Lan
 
<120>  INFLUENZA HEMAGGLUTININ PROTEIN VACCINES

<130>  24378

<140>  62/490,086
<141>  2017-04-26

<150>  62/411,240
<151>  2016-10-21

<160>  88    

<170>  PatentIn version 3.5

<210>  1
<211>  191
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BHA10-2: HA10

<400>  1

Met Glu Thr Pro Ala Gln Leu Leu Phe Leu Leu Leu Leu Trp Leu Pro 
1               5                   10                  15      


Asp Thr Thr Gly His Val Val Lys Thr Ala Thr Gln Gly Glu Val Asn 
            20                  25                  30          


Val Thr Gly Val Ile Pro Leu Thr Thr Thr Pro Thr Gly Ser Ala Asn 
        35                  40                  45              


Lys Ser Lys Pro Tyr Tyr Thr Gly Glu His Ala Lys Ala Thr Gly Asn 
    50                  55                  60                  


Cys Pro Ile Trp Val Lys Thr Pro Leu Lys Leu Ala Asn Gly Thr Lys 
65                  70                  75                  80  


Tyr Gly Ser Ala Gly Ser Ala Thr Gln Glu Ala Ile Asn Lys Ile Thr 
                85                  90                  95      


Lys Asn Leu Asn Ser Leu Ser Glu Leu Glu Val Lys Asn Leu Gln Arg 
            100                 105                 110         


Leu Ser Gly Ala Ser Asp Glu Thr His Asn Glu Ile Leu Glu Leu Asp 
        115                 120                 125             


Glu Lys Val Asp Asp Leu Arg Ala Asp Thr Ile Ser Ser Gln Ile Glu 
    130                 135                 140                 


Leu Ala Val Leu Leu Ser Asn Glu Gly Ile Ile Asn Ser Glu Asp Glu 
145                 150                 155                 160 


Gly Thr Gly Gly Gly Tyr Ile Pro Glu Ala Pro Arg Asp Gly Gln Ala 
                165                 170                 175     


Tyr Val Arg Lys Asp Gly Glu Trp Val Leu Leu Ser Thr Phe Leu 
            180                 185                 190     


<210>  2
<211>  160
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BHA10-3:BHA10-2

<400>  2

Met Glu Thr Pro Ala Gln Leu Leu Phe Leu Leu Leu Leu Trp Leu Pro 
1               5                   10                  15      


Asp Thr Thr Gly His Val Val Lys Thr Ala Thr Gln Gly Glu Val Asn 
            20                  25                  30          


Val Thr Gly Val Ile Pro Leu Thr Thr Thr Pro Thr Gly Ser Ala Asn 
        35                  40                  45              


Lys Ser Lys Pro Tyr Tyr Thr Gly Glu His Ala Lys Ala Thr Gly Asn 
    50                  55                  60                  


Cys Pro Ile Trp Val Lys Thr Pro Leu Lys Leu Ala Asn Gly Thr Lys 
65                  70                  75                  80  


Tyr Gly Ser Ala Gly Ser Ala Thr Gln Glu Ala Ile Asn Lys Ile Thr 
                85                  90                  95      


Lys Asn Leu Asn Ser Leu Ser Glu Leu Glu Val Lys Asn Leu Gln Arg 
            100                 105                 110         


Leu Ser Cys Ala Ser Asp Glu Thr His Asn Cys Ile Leu Glu Leu Asp 
        115                 120                 125             


Glu Lys Val Asp Asp Leu Arg Ala Asp Thr Ile Ser Ser Leu Ile Glu 
    130                 135                 140                 


Leu Ala Val Leu Leu Ser Asn Glu Gly Ile Ile Asn Ser Glu Asp Glu 
145                 150                 155                 160 


<210>  3
<211>  260
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  NIHGen6HASS-TM

<400>  3

Met Glu Thr Pro Ala Gln Leu Leu Phe Leu Leu Leu Leu Trp Leu Pro 
1               5                   10                  15      


Asp Thr Thr Gly Asp Thr Ile Cys Ile Gly Tyr His Ala Asn Asn Ser 
            20                  25                  30          


Thr Asp Thr Val Asp Thr Val Leu Glu Lys Asn Val Thr Val Thr His 
        35                  40                  45              


Ser Val Asn Leu Gly Ser Gly Leu Arg Met Val Thr Gly Leu Arg Asn 
    50                  55                  60                  


Ile Pro Gln Arg Glu Thr Arg Gly Leu Phe Gly Ala Ile Ala Gly Phe 
65                  70                  75                  80  


Ile Glu Gly Gly Trp Thr Gly Met Val Asp Gly Trp Tyr Gly Tyr His 
                85                  90                  95      


His Gln Asn Glu Gln Gly Ser Gly Tyr Ala Ala Asp Gln Lys Ser Thr 
            100                 105                 110         


Gln Asn Ala Ile Asn Gly Ile Thr Asn Met Val Asn Ser Val Ile Glu 
        115                 120                 125             


Lys Met Gly Ser Gly Gly Ser Gly Thr Asp Leu Ala Glu Leu Leu Val 
    130                 135                 140                 


Leu Leu Leu Asn Glu Arg Thr Leu Asp Phe His Asp Ser Asn Val Lys 
145                 150                 155                 160 


Asn Leu Tyr Glu Lys Val Lys Ser Gln Leu Lys Asn Asn Ala Lys Glu 
                165                 170                 175     


Ile Gly Asn Gly Cys Phe Glu Phe Tyr His Lys Cys Asn Asn Glu Cys 
            180                 185                 190         


Met Glu Ser Val Lys Asn Gly Thr Tyr Asp Tyr Pro Lys Tyr Ser Glu 
        195                 200                 205             


Glu Ser Lys Leu Asn Arg Glu Lys Ile Asp Gln Gly Thr Gly Gly Ile 
    210                 215                 220                 


Leu Ala Ile Tyr Ser Thr Val Ala Ser Ser Leu Val Leu Leu Val Ser 
225                 230                 235                 240 


Leu Gly Ala Ile Ser Phe Trp Met Cys Ser Asn Gly Ser Leu Gln Cys 
                245                 250                 255     


Arg Ile Cys Ile 
            260 


<210>  4
<211>  266
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  NIHGen6HASS-TM2

<400>  4

Met Glu Thr Pro Ala Gln Leu Leu Phe Leu Leu Leu Leu Trp Leu Pro 
1               5                   10                  15      


Asp Thr Thr Gly Asp Thr Ile Cys Ile Gly Tyr His Ala Asn Asn Ser 
            20                  25                  30          


Thr Asp Thr Val Asp Thr Val Leu Glu Lys Asn Val Thr Val Thr His 
        35                  40                  45              


Ser Val Asn Leu Gly Ser Gly Leu Arg Met Val Thr Gly Leu Arg Asn 
    50                  55                  60                  


Ile Pro Gln Arg Glu Thr Arg Gly Leu Phe Gly Ala Ile Ala Gly Phe 
65                  70                  75                  80  


Ile Glu Gly Gly Trp Thr Gly Met Val Asp Gly Trp Tyr Gly Tyr His 
                85                  90                  95      


His Gln Asn Glu Gln Gly Ser Gly Tyr Ala Ala Asp Gln Lys Ser Thr 
            100                 105                 110         


Gln Asn Ala Ile Asn Gly Ile Thr Asn Met Val Asn Ser Val Ile Glu 
        115                 120                 125             


Lys Met Gly Ser Gly Gly Ser Gly Thr Asp Leu Ala Glu Leu Leu Val 
    130                 135                 140                 


Leu Leu Leu Asn Glu Arg Thr Leu Asp Phe His Asp Ser Asn Val Lys 
145                 150                 155                 160 


Asn Leu Tyr Glu Lys Val Lys Ser Gln Leu Lys Asn Asn Ala Lys Glu 
                165                 170                 175     


Ile Gly Asn Gly Cys Phe Glu Phe Tyr His Lys Cys Asn Asn Glu Cys 
            180                 185                 190         


Met Glu Ser Val Lys Asn Gly Thr Tyr Asp Tyr Pro Lys Tyr Ser Glu 
        195                 200                 205             


Glu Ser Lys Leu Asn Arg Glu Lys Ile Asp Gly Val Lys Leu Glu Ser 
    210                 215                 220                 


Met Gly Val Tyr Gln Ile Leu Ala Ile Tyr Ser Thr Val Ala Ser Ser 
225                 230                 235                 240 


Leu Val Leu Leu Val Ser Leu Gly Ala Ile Ser Phe Trp Met Cys Ser 
                245                 250                 255     


Asn Gly Ser Leu Gln Cys Arg Ile Cys Ile 
            260                 265     


<210>  5
<211>  248
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  NIHGen6HASS

<400>  5

Met Glu Thr Pro Ala Gln Leu Leu Phe Leu Leu Leu Leu Trp Leu Pro 
1               5                   10                  15      


Asp Thr Thr Gly Asp Thr Ile Cys Ile Gly Tyr His Ala Asn Asn Ser 
            20                  25                  30          


Thr Asp Thr Val Asp Thr Val Leu Glu Lys Asn Val Thr Val Thr His 
        35                  40                  45              


Ser Val Asn Leu Gly Ser Gly Leu Arg Met Val Thr Gly Leu Arg Asn 
    50                  55                  60                  


Ile Pro Gln Arg Glu Thr Arg Gly Leu Phe Gly Ala Ile Ala Gly Phe 
65                  70                  75                  80  


Ile Glu Gly Gly Trp Thr Gly Met Val Asp Gly Trp Tyr Gly Tyr His 
                85                  90                  95      


His Gln Asn Glu Gln Gly Ser Gly Tyr Ala Ala Asp Gln Lys Ser Thr 
            100                 105                 110         


Gln Asn Ala Ile Asn Gly Ile Thr Asn Met Val Asn Ser Val Ile Glu 
        115                 120                 125             


Lys Met Gly Ser Gly Gly Ser Gly Thr Asp Leu Ala Glu Leu Leu Val 
    130                 135                 140                 


Leu Leu Leu Asn Glu Arg Thr Leu Asp Phe His Asp Ser Asn Val Lys 
145                 150                 155                 160 


Asn Leu Tyr Glu Lys Val Lys Ser Gln Leu Lys Asn Asn Ala Lys Glu 
                165                 170                 175     


Ile Gly Asn Gly Cys Phe Glu Phe Tyr His Lys Cys Asn Asn Glu Cys 
            180                 185                 190         


Met Glu Ser Val Lys Asn Gly Thr Tyr Asp Tyr Pro Lys Tyr Ser Glu 
        195                 200                 205             


Glu Ser Lys Leu Asn Arg Glu Lys Ile Asp Pro Gly Ser Gly Tyr Ile 
    210                 215                 220                 


Pro Glu Ala Pro Arg Asp Gly Gln Ala Tyr Val Arg Lys Asp Gly Glu 
225                 230                 235                 240 


Trp Val Leu Leu Ser Thr Phe Leu 
                245             


<210>  6
<211>  566
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ConH1

<400>  6

Met Lys Ala Lys Leu Leu Val Leu Leu Cys Ala Phe Thr Ala Thr Asp 
1               5                   10                  15      


Ala Asp Thr Ile Cys Ile Gly Tyr His Ala Asn Asn Ser Thr Asp Thr 
            20                  25                  30          


Val Asp Thr Val Leu Glu Lys Asn Val Thr Val Thr His Ser Val Asn 
        35                  40                  45              


Leu Leu Glu Asp Ser His Asn Gly Lys Leu Cys Lys Leu Lys Gly Ile 
    50                  55                  60                  


Ala Pro Leu Gln Leu Gly Lys Cys Asn Ile Ala Gly Trp Ile Leu Gly 
65                  70                  75                  80  


Asn Pro Glu Cys Glu Ser Leu Ile Ser Lys Arg Ser Trp Ser Tyr Ile 
                85                  90                  95      


Val Glu Thr Pro Asn Ser Glu Asn Gly Thr Cys Tyr Pro Gly Asp Phe 
            100                 105                 110         


Ala Asp Tyr Glu Glu Leu Arg Glu Gln Leu Ser Ser Val Ser Ser Phe 
        115                 120                 125             


Glu Arg Phe Glu Ile Phe Pro Lys Glu Ser Ser Trp Pro Asn His Asn 
    130                 135                 140                 


Val Thr Lys Gly Val Thr Ala Ala Cys Ser His Ala Gly Lys Ser Ser 
145                 150                 155                 160 


Phe Tyr Arg Asn Leu Leu Trp Leu Thr Glu Lys Asn Gly Ser Tyr Pro 
                165                 170                 175     


Lys Leu Ser Lys Ser Tyr Val Asn Asn Lys Glu Lys Glu Val Leu Val 
            180                 185                 190         


Leu Trp Gly Val His His Pro Ser Asn Ile Thr Asp Gln Arg Thr Leu 
        195                 200                 205             


Tyr Gln Asn Glu Asn Ala Tyr Val Ser Val Val Ser Ser His Tyr Asn 
    210                 215                 220                 


Arg Arg Phe Thr Pro Glu Ile Ala Lys Arg Pro Lys Val Arg Gly Gln 
225                 230                 235                 240 


Ala Gly Arg Ile Asn Tyr Tyr Trp Thr Leu Leu Glu Pro Gly Asp Thr 
                245                 250                 255     


Ile Ile Phe Glu Ala Asn Gly Asn Leu Ile Ala Pro Trp Tyr Ala Phe 
            260                 265                 270         


Ala Leu Ser Arg Gly Phe Gly Ser Gly Ile Ile Thr Ser Asn Ala Pro 
        275                 280                 285             


Met His Glu Cys Asp Thr Lys Cys Gln Thr Pro Gln Gly Ala Ile Asn 
    290                 295                 300                 


Ser Ser Leu Pro Phe Gln Asn Val His Pro Val Thr Ile Gly Glu Cys 
305                 310                 315                 320 


Pro Lys Tyr Val Arg Ser Thr Lys Leu Arg Met Val Thr Gly Leu Arg 
                325                 330                 335     


Asn Ile Pro Ser Ile Gln Ser Arg Gly Leu Phe Gly Ala Ile Ala Gly 
            340                 345                 350         


Phe Ile Glu Gly Gly Trp Thr Gly Met Ile Asp Gly Trp Tyr Gly Tyr 
        355                 360                 365             


His His Gln Asn Glu Gln Gly Ser Gly Tyr Ala Ala Asp Gln Lys Ser 
    370                 375                 380                 


Thr Gln Asn Ala Ile Asn Gly Ile Thr Asn Lys Val Asn Ser Val Ile 
385                 390                 395                 400 


Glu Lys Met Asn Thr Gln Phe Thr Ala Val Gly Lys Glu Phe Asn Lys 
                405                 410                 415     


Leu Glu Lys Arg Met Glu Asn Leu Asn Lys Lys Val Asp Asp Gly Phe 
            420                 425                 430         


Leu Asp Ile Trp Thr Tyr Asn Ala Glu Leu Leu Val Leu Leu Glu Asn 
        435                 440                 445             


Glu Arg Thr Leu Asp Phe His Asp Ser Asn Val Lys Asn Leu Tyr Glu 
    450                 455                 460                 


Lys Val Lys Ser Gln Leu Lys Asn Asn Ala Lys Glu Ile Gly Asn Gly 
465                 470                 475                 480 


Cys Phe Glu Phe Tyr His Lys Cys Asn Asn Glu Cys Met Glu Ser Val 
                485                 490                 495     


Lys Asn Gly Thr Tyr Asp Tyr Pro Lys Tyr Ser Glu Glu Ser Lys Leu 
            500                 505                 510         


Asn Arg Glu Lys Ile Asp Gly Val Lys Leu Glu Ser Met Gly Val Tyr 
        515                 520                 525             


Gln Ile Leu Ala Ile Tyr Ser Thr Val Ala Ser Ser Leu Val Leu Leu 
    530                 535                 540                 


Val Ser Leu Gly Ala Ile Ser Phe Trp Met Cys Ser Asn Gly Ser Leu 
545                 550                 555                 560 


Gln Cys Arg Ile Cys Ile 
                565     


<210>  7
<211>  566
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ConH3

<400>  7

Met Lys Thr Ile Ile Ala Leu Ser Tyr Ile Phe Cys Leu Val Phe Ala 
1               5                   10                  15      


Gln Lys Leu Pro Gly Asn Asp Asn Ser Thr Ala Thr Leu Cys Leu Gly 
            20                  25                  30          


His His Ala Val Pro Asn Gly Thr Leu Val Lys Thr Ile Thr Asn Asp 
        35                  40                  45              


Gln Ile Glu Val Thr Asn Ala Thr Glu Leu Val Gln Ser Ser Ser Thr 
    50                  55                  60                  


Gly Arg Ile Cys Asp Ser Pro His Arg Ile Leu Asp Gly Thr Asn Cys 
65                  70                  75                  80  


Thr Leu Ile Asp Ala Leu Leu Gly Asp Pro His Cys Asp Gly Phe Gln 
                85                  90                  95      


Asn Lys Glu Trp Asp Leu Phe Val Glu Arg Ser Lys Ala Tyr Ser Asn 
            100                 105                 110         


Cys Tyr Pro Tyr Asp Val Pro Asp Tyr Ala Ser Leu Arg Ser Leu Val 
        115                 120                 125             


Ala Ser Ser Gly Thr Leu Glu Phe Asn Asn Glu Gly Phe Asn Trp Thr 
    130                 135                 140                 


Gly Val Thr Gln Asn Gly Gly Ser Ser Ala Cys Lys Arg Gly Ser Asp 
145                 150                 155                 160 


Lys Ser Phe Phe Ser Arg Leu Asn Trp Leu His Lys Leu Lys Tyr Lys 
                165                 170                 175     


Tyr Pro Ala Leu Asn Val Thr Met Pro Asn Asn Asp Lys Phe Asp Lys 
            180                 185                 190         


Leu Tyr Ile Trp Gly Val His His Pro Ser Thr Asp Ser Asp Gln Thr 
        195                 200                 205             


Ser Leu Tyr Val Gln Ala Ser Gly Arg Val Thr Val Ser Thr Lys Arg 
    210                 215                 220                 


Ser Gln Gln Thr Val Ile Pro Asn Ile Gly Ser Arg Pro Trp Val Arg 
225                 230                 235                 240 


Gly Leu Ser Ser Arg Ile Ser Ile Tyr Trp Thr Ile Val Lys Pro Gly 
                245                 250                 255     


Asp Ile Leu Leu Ile Asn Ser Thr Gly Asn Leu Ile Ala Pro Arg Gly 
            260                 265                 270         


Tyr Phe Lys Ile Arg Ser Gly Lys Ser Ser Ile Met Arg Ser Asp Ala 
        275                 280                 285             


Pro Ile Gly Thr Cys Asn Ser Glu Cys Ile Thr Pro Asn Gly Ser Ile 
    290                 295                 300                 


Pro Asn Asp Lys Pro Phe Gln Asn Val Asn Arg Ile Thr Tyr Gly Ala 
305                 310                 315                 320 


Cys Pro Arg Tyr Val Lys Gln Asn Thr Leu Lys Leu Ala Thr Gly Met 
                325                 330                 335     


Arg Asn Val Pro Glu Lys Gln Thr Arg Gly Ile Phe Gly Ala Ile Ala 
            340                 345                 350         


Gly Phe Ile Glu Asn Gly Trp Glu Gly Met Val Asp Gly Trp Tyr Gly 
        355                 360                 365             


Phe Arg His Gln Asn Ser Glu Gly Thr Gly Gln Ala Ala Asp Leu Lys 
    370                 375                 380                 


Ser Thr Gln Ala Ala Ile Asp Gln Ile Asn Gly Lys Leu Asn Arg Leu 
385                 390                 395                 400 


Ile Glu Lys Thr Asn Glu Lys Phe His Gln Ile Glu Lys Glu Phe Ser 
                405                 410                 415     


Glu Val Glu Gly Arg Ile Gln Asp Leu Glu Lys Tyr Val Glu Asp Thr 
            420                 425                 430         


Lys Ile Asp Leu Trp Ser Tyr Asn Ala Glu Leu Leu Val Ala Leu Glu 
        435                 440                 445             


Asn Gln His Thr Ile Asp Leu Thr Asp Ser Glu Met Asn Lys Leu Phe 
    450                 455                 460                 


Glu Arg Thr Arg Lys Gln Leu Arg Glu Asn Ala Glu Asp Met Gly Asn 
465                 470                 475                 480 


Gly Cys Phe Lys Ile Tyr His Lys Cys Asp Asn Ala Cys Ile Gly Ser 
                485                 490                 495     


Ile Arg Asn Gly Thr Tyr Asp His Asp Val Tyr Arg Asp Glu Ala Leu 
            500                 505                 510         


Asn Asn Arg Phe Gln Ile Lys Gly Val Glu Leu Lys Ser Gly Tyr Lys 
        515                 520                 525             


Asp Trp Ile Leu Trp Ile Ser Phe Ala Ile Ser Cys Phe Leu Leu Cys 
    530                 535                 540                 


Val Val Leu Leu Gly Phe Ile Met Trp Ala Cys Gln Lys Gly Asn Ile 
545                 550                 555                 560 


Arg Cys Asn Ile Cys Ile 
                565     


<210>  8
<211>  566
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MRK_pH1_Con

<400>  8

Met Lys Ala Ile Leu Val Val Leu Leu Tyr Thr Phe Ala Thr Ala Asn 
1               5                   10                  15      


Ala Asp Thr Leu Cys Ile Gly Tyr His Ala Asn Asn Ser Thr Asp Thr 
            20                  25                  30          


Val Asp Thr Val Leu Glu Lys Asn Val Thr Val Thr His Ser Val Asn 
        35                  40                  45              


Leu Leu Glu Asp Lys His Asn Gly Lys Leu Cys Lys Leu Arg Gly Val 
    50                  55                  60                  


Ala Pro Leu His Leu Gly Lys Cys Asn Ile Ala Gly Trp Ile Leu Gly 
65                  70                  75                  80  


Asn Pro Glu Cys Glu Ser Leu Ser Thr Ala Ser Ser Trp Ser Tyr Ile 
                85                  90                  95      


Val Glu Thr Ser Ser Ser Asp Asn Gly Thr Cys Tyr Pro Gly Asp Phe 
            100                 105                 110         


Ile Asp Tyr Glu Glu Leu Arg Glu Gln Leu Ser Ser Val Ser Ser Phe 
        115                 120                 125             


Glu Arg Phe Glu Ile Phe Pro Lys Thr Ser Ser Trp Pro Asn His Asp 
    130                 135                 140                 


Ser Asn Lys Gly Val Thr Ala Ala Cys Pro His Ala Gly Ala Lys Ser 
145                 150                 155                 160 


Phe Tyr Lys Asn Leu Ile Trp Leu Val Lys Lys Gly Asn Ser Tyr Pro 
                165                 170                 175     


Lys Leu Ser Lys Ser Tyr Ile Asn Asp Lys Gly Lys Glu Val Leu Val 
            180                 185                 190         


Leu Trp Gly Ile His His Pro Ser Thr Ser Ala Asp Gln Gln Ser Leu 
        195                 200                 205             


Tyr Gln Asn Ala Asp Ala Tyr Val Phe Val Gly Thr Ser Arg Tyr Ser 
    210                 215                 220                 


Lys Lys Phe Lys Pro Glu Ile Ala Ile Arg Pro Lys Val Arg Asp Gln 
225                 230                 235                 240 


Glu Gly Arg Met Asn Tyr Tyr Trp Thr Leu Val Glu Pro Gly Asp Lys 
                245                 250                 255     


Ile Thr Phe Glu Ala Thr Gly Asn Leu Val Val Pro Arg Tyr Ala Phe 
            260                 265                 270         


Ala Met Glu Arg Asn Ala Gly Ser Gly Ile Ile Ile Ser Asp Thr Pro 
        275                 280                 285             


Val His Asp Cys Asn Thr Thr Cys Gln Thr Pro Lys Gly Ala Ile Asn 
    290                 295                 300                 


Thr Ser Leu Pro Phe Gln Asn Ile His Pro Ile Thr Ile Gly Lys Cys 
305                 310                 315                 320 


Pro Lys Tyr Val Lys Ser Thr Lys Leu Arg Leu Ala Thr Gly Leu Arg 
                325                 330                 335     


Asn Val Pro Ser Ile Gln Ser Arg Gly Leu Phe Gly Ala Ile Ala Gly 
            340                 345                 350         


Phe Ile Glu Gly Gly Trp Thr Gly Met Val Asp Gly Trp Tyr Gly Tyr 
        355                 360                 365             


His His Gln Asn Glu Gln Gly Ser Gly Tyr Ala Ala Asp Leu Lys Ser 
    370                 375                 380                 


Thr Gln Asn Ala Ile Asp Lys Ile Thr Asn Lys Val Asn Ser Val Ile 
385                 390                 395                 400 


Glu Lys Met Asn Thr Gln Phe Thr Ala Val Gly Lys Glu Phe Asn His 
                405                 410                 415     


Leu Glu Lys Arg Ile Glu Asn Leu Asn Lys Lys Val Asp Asp Gly Phe 
            420                 425                 430         


Leu Asp Ile Trp Thr Tyr Asn Ala Glu Leu Leu Val Leu Leu Glu Asn 
        435                 440                 445             


Glu Arg Thr Leu Asp Tyr His Asp Ser Asn Val Lys Asn Leu Tyr Glu 
    450                 455                 460                 


Lys Val Arg Ser Gln Leu Lys Asn Asn Ala Lys Glu Ile Gly Asn Gly 
465                 470                 475                 480 


Cys Phe Glu Phe Tyr His Lys Cys Asp Asn Thr Cys Met Glu Ser Val 
                485                 490                 495     


Lys Asn Gly Thr Tyr Asp Tyr Pro Lys Tyr Ser Glu Glu Ala Lys Leu 
            500                 505                 510         


Asn Arg Glu Glu Ile Asp Gly Val Lys Leu Glu Ser Thr Arg Ile Tyr 
        515                 520                 525             


Gln Ile Leu Ala Ile Tyr Ser Thr Val Ala Ser Ser Leu Val Leu Val 
    530                 535                 540                 


Val Ser Leu Gly Ala Ile Ser Phe Trp Met Cys Ser Asn Gly Ser Leu 
545                 550                 555                 560 


Gln Cys Arg Ile Cys Ile 
                565     


<210>  9
<211>  529
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MRK_pH1_Con

<400>  9

Met Lys Ala Ile Leu Val Val Leu Leu Tyr Thr Phe Ala Thr Ala Asn 
1               5                   10                  15      


Ala Asp Thr Leu Cys Ile Gly Tyr His Ala Asn Asn Ser Thr Asp Thr 
            20                  25                  30          


Val Asp Thr Val Leu Glu Lys Asn Val Thr Val Thr His Ser Val Asn 
        35                  40                  45              


Leu Leu Glu Asp Lys His Asn Gly Lys Leu Cys Lys Leu Arg Gly Val 
    50                  55                  60                  


Ala Pro Leu His Leu Gly Lys Cys Asn Ile Ala Gly Trp Ile Leu Gly 
65                  70                  75                  80  


Asn Pro Glu Cys Glu Ser Leu Ser Thr Ala Ser Ser Trp Ser Tyr Ile 
                85                  90                  95      


Val Glu Thr Ser Ser Ser Asp Asn Gly Thr Cys Tyr Pro Gly Asp Phe 
            100                 105                 110         


Ile Asp Tyr Glu Glu Leu Arg Glu Gln Leu Ser Ser Val Ser Ser Phe 
        115                 120                 125             


Glu Arg Phe Glu Ile Phe Pro Lys Thr Ser Ser Trp Pro Asn His Asp 
    130                 135                 140                 


Ser Asn Lys Gly Val Thr Ala Ala Cys Pro His Ala Gly Ala Lys Ser 
145                 150                 155                 160 


Phe Tyr Lys Asn Leu Ile Trp Leu Val Lys Lys Gly Asn Ser Tyr Pro 
                165                 170                 175     


Lys Leu Ser Lys Ser Tyr Ile Asn Asp Lys Gly Lys Glu Val Leu Val 
            180                 185                 190         


Leu Trp Gly Ile His His Pro Ser Thr Ser Ala Asp Gln Gln Ser Leu 
        195                 200                 205             


Tyr Gln Asn Ala Asp Ala Tyr Val Phe Val Gly Thr Ser Arg Tyr Ser 
    210                 215                 220                 


Lys Lys Phe Lys Pro Glu Ile Ala Ile Arg Pro Lys Val Arg Asp Gln 
225                 230                 235                 240 


Glu Gly Arg Met Asn Tyr Tyr Trp Thr Leu Val Glu Pro Gly Asp Lys 
                245                 250                 255     


Ile Thr Phe Glu Ala Thr Gly Asn Leu Val Val Pro Arg Tyr Ala Phe 
            260                 265                 270         


Ala Met Glu Arg Asn Ala Gly Ser Gly Ile Ile Ile Ser Asp Thr Pro 
        275                 280                 285             


Val His Asp Cys Asn Thr Thr Cys Gln Thr Pro Lys Gly Ala Ile Asn 
    290                 295                 300                 


Thr Ser Leu Pro Phe Gln Asn Ile His Pro Ile Thr Ile Gly Lys Cys 
305                 310                 315                 320 


Pro Lys Tyr Val Lys Ser Thr Lys Leu Arg Leu Ala Thr Gly Leu Arg 
                325                 330                 335     


Asn Val Pro Ser Ile Gln Ser Arg Gly Leu Phe Gly Ala Ile Ala Gly 
            340                 345                 350         


Phe Ile Glu Gly Gly Trp Thr Gly Met Val Asp Gly Trp Tyr Gly Tyr 
        355                 360                 365             


His His Gln Asn Glu Gln Gly Ser Gly Tyr Ala Ala Asp Leu Lys Ser 
    370                 375                 380                 


Thr Gln Asn Ala Ile Asp Lys Ile Thr Asn Lys Val Asn Ser Val Ile 
385                 390                 395                 400 


Glu Lys Met Asn Thr Gln Phe Thr Ala Val Gly Lys Glu Phe Asn His 
                405                 410                 415     


Leu Glu Lys Arg Ile Glu Asn Leu Asn Lys Lys Val Asp Asp Gly Phe 
            420                 425                 430         


Leu Asp Ile Trp Thr Tyr Asn Ala Glu Leu Leu Val Leu Leu Glu Asn 
        435                 440                 445             


Glu Arg Thr Leu Asp Tyr His Asp Ser Asn Val Lys Asn Leu Tyr Glu 
    450                 455                 460                 


Lys Val Arg Ser Gln Leu Lys Asn Asn Ala Lys Glu Ile Gly Asn Gly 
465                 470                 475                 480 


Cys Phe Glu Phe Tyr His Lys Cys Asp Asn Thr Cys Met Glu Ser Val 
                485                 490                 495     


Lys Asn Gly Thr Tyr Asp Tyr Pro Lys Tyr Ser Glu Glu Ala Lys Leu 
            500                 505                 510         


Asn Arg Glu Glu Ile Asp Gly Val Lys Leu Glu Ser Thr Arg Ile Tyr 
        515                 520                 525             


Gln 
    


<210>  10
<211>  565
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MRK_sH1_Con

<400>  10

Met Lys Val Lys Leu Leu Val Leu Leu Cys Thr Phe Thr Ala Thr Tyr 
1               5                   10                  15      


Ala Asp Thr Ile Cys Ile Gly Tyr His Ala Asn Asn Ser Thr Asp Thr 
            20                  25                  30          


Val Asp Thr Val Leu Glu Lys Asn Val Thr Val Thr His Ser Val Asn 
        35                  40                  45              


Leu Leu Glu Asp Ser His Asn Gly Lys Leu Cys Leu Leu Lys Gly Ile 
    50                  55                  60                  


Ala Pro Leu Gln Leu Gly Asn Cys Ser Val Ala Gly Trp Ile Leu Gly 
65                  70                  75                  80  


Asn Pro Glu Cys Glu Leu Leu Ile Ser Lys Glu Ser Trp Ser Tyr Ile 
                85                  90                  95      


Val Glu Thr Pro Asn Pro Glu Asn Gly Thr Cys Tyr Pro Gly Tyr Phe 
            100                 105                 110         


Ala Asp Tyr Glu Glu Leu Arg Glu Gln Leu Ser Ser Val Ser Ser Phe 
        115                 120                 125             


Glu Arg Phe Glu Ile Phe Pro Lys Glu Ser Ser Trp Pro Asn His Thr 
    130                 135                 140                 


Val Thr Gly Val Ser Ala Ser Cys Ser His Asn Gly Lys Ser Ser Phe 
145                 150                 155                 160 


Tyr Arg Asn Leu Leu Trp Leu Thr Gly Lys Asn Gly Leu Tyr Pro Asn 
                165                 170                 175     


Leu Ser Lys Ser Tyr Ala Asn Asn Lys Glu Lys Glu Val Leu Val Leu 
            180                 185                 190         


Trp Gly Val His His Pro Pro Asn Ile Gly Asp Gln Arg Ala Leu Tyr 
        195                 200                 205             


His Thr Glu Asn Ala Tyr Val Ser Val Val Ser Ser His Tyr Ser Arg 
    210                 215                 220                 


Arg Phe Thr Pro Glu Ile Ala Lys Arg Pro Lys Val Arg Asp Gln Glu 
225                 230                 235                 240 


Gly Arg Ile Asn Tyr Tyr Trp Thr Leu Leu Glu Pro Gly Asp Thr Ile 
                245                 250                 255     


Ile Phe Glu Ala Asn Gly Asn Leu Ile Ala Pro Arg Tyr Ala Phe Ala 
            260                 265                 270         


Leu Ser Arg Gly Phe Gly Ser Gly Ile Ile Thr Ser Asn Ala Pro Met 
        275                 280                 285             


Asp Glu Cys Asp Ala Lys Cys Gln Thr Pro Gln Gly Ala Ile Asn Ser 
    290                 295                 300                 


Ser Leu Pro Phe Gln Asn Val His Pro Val Thr Ile Gly Glu Cys Pro 
305                 310                 315                 320 


Lys Tyr Val Arg Ser Ala Lys Leu Arg Met Val Thr Gly Leu Arg Asn 
                325                 330                 335     


Ile Pro Ser Ile Gln Ser Arg Gly Leu Phe Gly Ala Ile Ala Gly Phe 
            340                 345                 350         


Ile Glu Gly Gly Trp Thr Gly Met Val Asp Gly Trp Tyr Gly Tyr His 
        355                 360                 365             


His Gln Asn Glu Gln Gly Ser Gly Tyr Ala Ala Asp Gln Lys Ser Thr 
    370                 375                 380                 


Gln Asn Ala Ile Asn Gly Ile Thr Asn Lys Val Asn Ser Val Ile Glu 
385                 390                 395                 400 


Lys Met Asn Thr Gln Phe Thr Ala Val Gly Lys Glu Phe Asn Lys Leu 
                405                 410                 415     


Glu Arg Arg Met Glu Asn Leu Asn Lys Lys Val Asp Asp Gly Phe Leu 
            420                 425                 430         


Asp Ile Trp Thr Tyr Asn Ala Glu Leu Leu Val Leu Leu Glu Asn Glu 
        435                 440                 445             


Arg Thr Leu Asp Phe His Asp Ser Asn Val Lys Asn Leu Tyr Glu Lys 
    450                 455                 460                 


Val Lys Ser Gln Leu Lys Asn Asn Ala Lys Glu Ile Gly Asn Gly Cys 
465                 470                 475                 480 


Phe Glu Phe Tyr His Lys Cys Asn Asp Glu Cys Met Glu Ser Val Lys 
                485                 490                 495     


Asn Gly Thr Tyr Asp Tyr Pro Lys Tyr Ser Glu Glu Ser Lys Leu Asn 
            500                 505                 510         


Arg Glu Lys Ile Asp Gly Val Lys Leu Glu Ser Met Gly Val Tyr Gln 
        515                 520                 525             


Ile Leu Ala Ile Tyr Ser Thr Val Ala Ser Ser Leu Val Leu Leu Val 
    530                 535                 540                 


Ser Leu Gly Ala Ile Ser Phe Trp Met Cys Ser Asn Gly Ser Leu Gln 
545                 550                 555                 560 


Cys Arg Ile Cys Ile 
                565 


<210>  11
<211>  528
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MRK_sH1_Con

<400>  11

Met Lys Val Lys Leu Leu Val Leu Leu Cys Thr Phe Thr Ala Thr Tyr 
1               5                   10                  15      


Ala Asp Thr Ile Cys Ile Gly Tyr His Ala Asn Asn Ser Thr Asp Thr 
            20                  25                  30          


Val Asp Thr Val Leu Glu Lys Asn Val Thr Val Thr His Ser Val Asn 
        35                  40                  45              


Leu Leu Glu Asp Ser His Asn Gly Lys Leu Cys Leu Leu Lys Gly Ile 
    50                  55                  60                  


Ala Pro Leu Gln Leu Gly Asn Cys Ser Val Ala Gly Trp Ile Leu Gly 
65                  70                  75                  80  


Asn Pro Glu Cys Glu Leu Leu Ile Ser Lys Glu Ser Trp Ser Tyr Ile 
                85                  90                  95      


Val Glu Thr Pro Asn Pro Glu Asn Gly Thr Cys Tyr Pro Gly Tyr Phe 
            100                 105                 110         


Ala Asp Tyr Glu Glu Leu Arg Glu Gln Leu Ser Ser Val Ser Ser Phe 
        115                 120                 125             


Glu Arg Phe Glu Ile Phe Pro Lys Glu Ser Ser Trp Pro Asn His Thr 
    130                 135                 140                 


Val Thr Gly Val Ser Ala Ser Cys Ser His Asn Gly Lys Ser Ser Phe 
145                 150                 155                 160 


Tyr Arg Asn Leu Leu Trp Leu Thr Gly Lys Asn Gly Leu Tyr Pro Asn 
                165                 170                 175     


Leu Ser Lys Ser Tyr Ala Asn Asn Lys Glu Lys Glu Val Leu Val Leu 
            180                 185                 190         


Trp Gly Val His His Pro Pro Asn Ile Gly Asp Gln Arg Ala Leu Tyr 
        195                 200                 205             


His Thr Glu Asn Ala Tyr Val Ser Val Val Ser Ser His Tyr Ser Arg 
    210                 215                 220                 


Arg Phe Thr Pro Glu Ile Ala Lys Arg Pro Lys Val Arg Asp Gln Glu 
225                 230                 235                 240 


Gly Arg Ile Asn Tyr Tyr Trp Thr Leu Leu Glu Pro Gly Asp Thr Ile 
                245                 250                 255     


Ile Phe Glu Ala Asn Gly Asn Leu Ile Ala Pro Arg Tyr Ala Phe Ala 
            260                 265                 270         


Leu Ser Arg Gly Phe Gly Ser Gly Ile Ile Thr Ser Asn Ala Pro Met 
        275                 280                 285             


Asp Glu Cys Asp Ala Lys Cys Gln Thr Pro Gln Gly Ala Ile Asn Ser 
    290                 295                 300                 


Ser Leu Pro Phe Gln Asn Val His Pro Val Thr Ile Gly Glu Cys Pro 
305                 310                 315                 320 


Lys Tyr Val Arg Ser Ala Lys Leu Arg Met Val Thr Gly Leu Arg Asn 
                325                 330                 335     


Ile Pro Ser Ile Gln Ser Arg Gly Leu Phe Gly Ala Ile Ala Gly Phe 
            340                 345                 350         


Ile Glu Gly Gly Trp Thr Gly Met Val Asp Gly Trp Tyr Gly Tyr His 
        355                 360                 365             


His Gln Asn Glu Gln Gly Ser Gly Tyr Ala Ala Asp Gln Lys Ser Thr 
    370                 375                 380                 


Gln Asn Ala Ile Asn Gly Ile Thr Asn Lys Val Asn Ser Val Ile Glu 
385                 390                 395                 400 


Lys Met Asn Thr Gln Phe Thr Ala Val Gly Lys Glu Phe Asn Lys Leu 
                405                 410                 415     


Glu Arg Arg Met Glu Asn Leu Asn Lys Lys Val Asp Asp Gly Phe Leu 
            420                 425                 430         


Asp Ile Trp Thr Tyr Asn Ala Glu Leu Leu Val Leu Leu Glu Asn Glu 
        435                 440                 445             


Arg Thr Leu Asp Phe His Asp Ser Asn Val Lys Asn Leu Tyr Glu Lys 
    450                 455                 460                 


Val Lys Ser Gln Leu Lys Asn Asn Ala Lys Glu Ile Gly Asn Gly Cys 
465                 470                 475                 480 


Phe Glu Phe Tyr His Lys Cys Asn Asp Glu Cys Met Glu Ser Val Lys 
                485                 490                 495     


Asn Gly Thr Tyr Asp Tyr Pro Lys Tyr Ser Glu Glu Ser Lys Leu Asn 
            500                 505                 510         


Arg Glu Lys Ile Asp Gly Val Lys Leu Glu Ser Met Gly Val Tyr Gln 
        515                 520                 525             


<210>  12
<211>  566
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Cobra_P1

<400>  12

Met Lys Ala Arg Leu Leu Val Leu Leu Cys Ala Leu Ala Ala Thr Asp 
1               5                   10                  15      


Ala Asp Thr Ile Cys Ile Gly Tyr His Ala Asn Asn Ser Thr Asp Thr 
            20                  25                  30          


Val Asp Thr Val Leu Glu Lys Asn Val Thr Val Thr His Ser Val Asn 
        35                  40                  45              


Leu Leu Glu Asp Ser His Asn Gly Lys Leu Cys Lys Leu Lys Gly Ile 
    50                  55                  60                  


Ala Pro Leu Gln Leu Gly Lys Cys Asn Ile Ala Gly Trp Leu Leu Gly 
65                  70                  75                  80  


Asn Pro Glu Cys Glu Ser Leu Leu Ser Ala Arg Ser Trp Ser Tyr Ile 
                85                  90                  95      


Val Glu Thr Pro Asn Ser Glu Asn Gly Thr Cys Tyr Pro Gly Asp Phe 
            100                 105                 110         


Ile Asp Tyr Glu Glu Leu Arg Glu Gln Leu Ser Ser Val Ser Ser Phe 
        115                 120                 125             


Glu Arg Phe Glu Ile Phe Pro Lys Glu Ser Ser Trp Pro Asn His Asn 
    130                 135                 140                 


Thr Thr Lys Gly Val Thr Ala Ala Cys Ser His Ala Gly Lys Ser Ser 
145                 150                 155                 160 


Phe Tyr Arg Asn Leu Leu Trp Leu Thr Lys Lys Gly Gly Ser Tyr Pro 
                165                 170                 175     


Lys Leu Ser Lys Ser Tyr Val Asn Asn Lys Gly Lys Glu Val Leu Val 
            180                 185                 190         


Leu Trp Gly Val His His Pro Ser Thr Ser Thr Asp Gln Gln Ser Leu 
        195                 200                 205             


Tyr Gln Asn Glu Asn Ala Tyr Val Ser Val Val Ser Ser Asn Tyr Asn 
    210                 215                 220                 


Arg Arg Phe Thr Pro Glu Ile Ala Glu Arg Pro Lys Val Arg Gly Gln 
225                 230                 235                 240 


Ala Gly Arg Met Asn Tyr Tyr Trp Thr Leu Leu Glu Pro Gly Asp Thr 
                245                 250                 255     


Ile Ile Phe Glu Ala Thr Gly Asn Leu Ile Ala Pro Trp Tyr Ala Phe 
            260                 265                 270         


Ala Leu Ser Arg Gly Ser Gly Ser Gly Ile Ile Thr Ser Asn Ala Ser 
        275                 280                 285             


Met His Glu Cys Asn Thr Lys Cys Gln Thr Pro Gln Gly Ala Ile Asn 
    290                 295                 300                 


Ser Ser Leu Pro Phe Gln Asn Ile His Pro Val Thr Ile Gly Glu Cys 
305                 310                 315                 320 


Pro Lys Tyr Val Arg Ser Thr Lys Leu Arg Met Val Thr Gly Leu Arg 
                325                 330                 335     


Asn Ile Pro Ser Ile Gln Ser Arg Gly Leu Phe Gly Ala Ile Ala Gly 
            340                 345                 350         


Phe Ile Glu Gly Gly Trp Thr Gly Met Ile Asp Gly Trp Tyr Gly Tyr 
        355                 360                 365             


His His Gln Asn Glu Gln Gly Ser Gly Tyr Ala Ala Asp Gln Lys Ser 
    370                 375                 380                 


Thr Gln Asn Ala Ile Asn Gly Ile Thr Asn Lys Val Asn Ser Val Ile 
385                 390                 395                 400 


Glu Lys Met Asn Thr Gln Phe Thr Ala Val Gly Lys Glu Phe Asn Asn 
                405                 410                 415     


Leu Glu Lys Arg Met Glu Asn Leu Asn Lys Lys Val Asp Asp Gly Phe 
            420                 425                 430         


Leu Asp Ile Trp Thr Tyr Asn Ala Glu Leu Leu Val Leu Leu Glu Asn 
        435                 440                 445             


Glu Arg Thr Leu Asp Phe His Asp Ser Asn Val Lys Asn Leu Tyr Glu 
    450                 455                 460                 


Lys Val Lys Ser Gln Leu Arg Asn Asn Ala Lys Glu Ile Gly Asn Gly 
465                 470                 475                 480 


Cys Phe Glu Phe Tyr His Lys Cys Asp Asn Glu Cys Met Glu Ser Val 
                485                 490                 495     


Lys Asn Gly Thr Tyr Asp Tyr Pro Lys Tyr Ser Glu Glu Ser Lys Leu 
            500                 505                 510         


Asn Arg Glu Lys Ile Asp Gly Val Lys Leu Glu Ser Met Gly Val Tyr 
        515                 520                 525             


Gln Ile Leu Ala Ile Tyr Ser Thr Val Ala Ser Ser Leu Val Leu Leu 
    530                 535                 540                 


Val Ser Leu Gly Ala Ile Ser Phe Trp Met Cys Ser Asn Gly Ser Leu 
545                 550                 555                 560 


Gln Cys Arg Ile Cys Ile 
                565     


<210>  13
<211>  566
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Cobra_X3

<400>  13

Met Glu Ala Arg Leu Leu Val Leu Leu Cys Ala Phe Ala Ala Thr Asn 
1               5                   10                  15      


Ala Asp Thr Ile Cys Ile Gly Tyr His Ala Asn Asn Ser Thr Asp Thr 
            20                  25                  30          


Val Asp Thr Val Leu Glu Lys Asn Val Thr Val Thr His Ser Val Asn 
        35                  40                  45              


Leu Leu Glu Asp Ser His Asn Gly Lys Leu Cys Arg Leu Lys Gly Ile 
    50                  55                  60                  


Ala Pro Leu Gln Leu Gly Asn Cys Ser Val Ala Gly Trp Ile Leu Gly 
65                  70                  75                  80  


Asn Pro Glu Cys Glu Ser Leu Phe Ser Lys Glu Ser Trp Ser Tyr Ile 
                85                  90                  95      


Ala Glu Thr Pro Asn Pro Glu Asn Gly Thr Cys Tyr Pro Gly Tyr Phe 
            100                 105                 110         


Ala Asp Tyr Glu Glu Leu Arg Glu Gln Leu Ser Ser Val Ser Ser Phe 
        115                 120                 125             


Glu Arg Phe Glu Ile Phe Pro Lys Glu Ser Ser Trp Pro Asn His Thr 
    130                 135                 140                 


Val Thr Lys Gly Val Thr Ala Ser Cys Ser His Asn Gly Lys Ser Ser 
145                 150                 155                 160 


Phe Tyr Arg Asn Leu Leu Trp Leu Thr Glu Lys Asn Gly Leu Tyr Pro 
                165                 170                 175     


Asn Leu Ser Lys Ser Tyr Val Asn Asn Lys Glu Lys Glu Val Leu Val 
            180                 185                 190         


Leu Trp Gly Val His His Pro Ser Asn Ile Gly Asp Gln Arg Ala Ile 
        195                 200                 205             


Tyr His Thr Glu Asn Ala Tyr Val Ser Val Val Ser Ser His Tyr Ser 
    210                 215                 220                 


Arg Arg Phe Thr Pro Glu Ile Ala Lys Arg Pro Lys Val Arg Asp Gln 
225                 230                 235                 240 


Glu Gly Arg Ile Asn Tyr Tyr Trp Thr Leu Leu Glu Pro Gly Asp Thr 
                245                 250                 255     


Ile Ile Phe Glu Ala Asn Gly Asn Leu Ile Ala Pro Trp Tyr Ala Phe 
            260                 265                 270         


Ala Leu Ser Arg Gly Phe Gly Ser Gly Ile Ile Thr Ser Asn Ala Ser 
        275                 280                 285             


Met Asp Glu Cys Asp Ala Lys Cys Gln Thr Pro Gln Gly Ala Ile Asn 
    290                 295                 300                 


Ser Ser Leu Pro Phe Gln Asn Val His Pro Val Thr Ile Gly Glu Cys 
305                 310                 315                 320 


Pro Lys Tyr Val Arg Ser Thr Lys Leu Arg Met Val Thr Gly Leu Arg 
                325                 330                 335     


Asn Ile Pro Ser Ile Gln Ser Arg Gly Leu Phe Gly Ala Ile Ala Gly 
            340                 345                 350         


Phe Ile Glu Gly Gly Trp Thr Gly Met Ile Asp Gly Trp Tyr Gly Tyr 
        355                 360                 365             


His His Gln Asn Glu Gln Gly Ser Gly Tyr Ala Ala Asp Gln Lys Ser 
    370                 375                 380                 


Thr Gln Asn Ala Ile Asn Gly Ile Thr Asn Lys Val Asn Ser Val Ile 
385                 390                 395                 400 


Glu Lys Met Asn Thr Gln Phe Thr Ala Val Gly Lys Glu Phe Asn Lys 
                405                 410                 415     


Leu Glu Arg Arg Met Glu Asn Leu Asn Lys Lys Val Asp Asp Gly Phe 
            420                 425                 430         


Leu Asp Ile Trp Thr Tyr Asn Ala Glu Leu Leu Val Leu Leu Glu Asn 
        435                 440                 445             


Glu Arg Thr Leu Asp Phe His Asp Ser Asn Val Lys Asn Leu Tyr Glu 
    450                 455                 460                 


Lys Val Lys Ser Gln Leu Lys Asn Asn Ala Lys Glu Ile Gly Asn Gly 
465                 470                 475                 480 


Cys Phe Glu Phe Tyr His Lys Cys Asn Asn Glu Cys Met Glu Ser Val 
                485                 490                 495     


Lys Asn Gly Thr Tyr Asp Tyr Pro Lys Tyr Ser Glu Glu Ser Lys Leu 
            500                 505                 510         


Asn Arg Glu Lys Ile Asp Gly Val Lys Leu Glu Ser Met Gly Val Tyr 
        515                 520                 525             


Gln Ile Leu Ala Ile Tyr Ser Thr Val Ala Ser Ser Leu Val Leu Leu 
    530                 535                 540                 


Val Ser Leu Gly Ala Ile Ser Phe Trp Met Cys Ser Asn Gly Ser Leu 
545                 550                 555                 560 


Gln Cys Arg Ile Cys Ile 
                565     


<210>  14
<211>  684
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ConH1_ferritin

<400>  14

Met Lys Ala Lys Leu Leu Val Leu Leu Cys Ala Phe Thr Ala Thr Asp 
1               5                   10                  15      


Ala Asp Thr Ile Cys Ile Gly Tyr His Ala Asn Asn Ser Thr Asp Thr 
            20                  25                  30          


Val Asp Thr Val Leu Glu Lys Asn Val Thr Val Thr His Ser Val Asn 
        35                  40                  45              


Leu Leu Glu Asp Ser His Asn Gly Lys Leu Cys Lys Leu Lys Gly Ile 
    50                  55                  60                  


Ala Pro Leu Gln Leu Gly Lys Cys Asn Ile Ala Gly Trp Ile Leu Gly 
65                  70                  75                  80  


Asn Pro Glu Cys Glu Ser Leu Ile Ser Lys Arg Ser Trp Ser Tyr Ile 
                85                  90                  95      


Val Glu Thr Pro Asn Ser Glu Asn Gly Thr Cys Tyr Pro Gly Asp Phe 
            100                 105                 110         


Ala Asp Tyr Glu Glu Leu Arg Glu Gln Leu Ser Ser Val Ser Ser Phe 
        115                 120                 125             


Glu Arg Phe Glu Ile Phe Pro Lys Glu Ser Ser Trp Pro Asn His Asn 
    130                 135                 140                 


Val Thr Lys Gly Val Thr Ala Ala Cys Ser His Ala Gly Lys Ser Ser 
145                 150                 155                 160 


Phe Tyr Arg Asn Leu Leu Trp Leu Thr Glu Lys Asn Gly Ser Tyr Pro 
                165                 170                 175     


Lys Leu Ser Lys Ser Tyr Val Asn Asn Lys Glu Lys Glu Val Leu Val 
            180                 185                 190         


Leu Trp Gly Val His His Pro Ser Asn Ile Thr Asp Gln Arg Thr Leu 
        195                 200                 205             


Tyr Gln Asn Glu Asn Ala Tyr Val Ser Val Val Ser Ser His Tyr Asn 
    210                 215                 220                 


Arg Arg Phe Thr Pro Glu Ile Ala Lys Arg Pro Lys Val Arg Gly Gln 
225                 230                 235                 240 


Ala Gly Arg Ile Asn Tyr Tyr Trp Thr Leu Leu Glu Pro Gly Asp Thr 
                245                 250                 255     


Ile Ile Phe Glu Ala Asn Gly Asn Leu Ile Ala Pro Trp Tyr Ala Phe 
            260                 265                 270         


Ala Leu Ser Arg Gly Phe Gly Ser Gly Ile Ile Thr Ser Asn Ala Pro 
        275                 280                 285             


Met His Glu Cys Asp Thr Lys Cys Gln Thr Pro Gln Gly Ala Ile Asn 
    290                 295                 300                 


Ser Ser Leu Pro Phe Gln Asn Val His Pro Val Thr Ile Gly Glu Cys 
305                 310                 315                 320 


Pro Lys Tyr Val Arg Ser Thr Lys Leu Arg Met Val Thr Gly Leu Arg 
                325                 330                 335     


Asn Ile Pro Ser Ile Gln Ser Arg Gly Leu Phe Gly Ala Ile Ala Gly 
            340                 345                 350         


Phe Ile Glu Gly Gly Trp Thr Gly Met Ile Asp Gly Trp Tyr Gly Tyr 
        355                 360                 365             


His His Gln Asn Glu Gln Gly Ser Gly Tyr Ala Ala Asp Gln Lys Ser 
    370                 375                 380                 


Thr Gln Asn Ala Ile Asn Gly Ile Thr Asn Lys Val Asn Ser Val Ile 
385                 390                 395                 400 


Glu Lys Met Asn Thr Gln Phe Thr Ala Val Gly Lys Glu Phe Asn Lys 
                405                 410                 415     


Leu Glu Lys Arg Met Glu Asn Leu Asn Lys Lys Val Asp Asp Gly Phe 
            420                 425                 430         


Leu Asp Ile Trp Thr Tyr Asn Ala Glu Leu Leu Val Leu Leu Glu Asn 
        435                 440                 445             


Glu Arg Thr Leu Asp Phe His Asp Ser Asn Val Lys Asn Leu Tyr Glu 
    450                 455                 460                 


Lys Val Lys Ser Gln Leu Lys Asn Asn Ala Lys Glu Ile Gly Asn Gly 
465                 470                 475                 480 


Cys Phe Glu Phe Tyr His Lys Cys Asn Asn Glu Cys Met Glu Ser Val 
                485                 490                 495     


Lys Asn Gly Thr Tyr Asp Tyr Pro Lys Tyr Ser Glu Glu Ser Lys Leu 
            500                 505                 510         


Asn Arg Glu Lys Ile Asp Ser Gly Gly Asp Ile Ile Lys Leu Leu Asn 
        515                 520                 525             


Glu Gln Val Asn Lys Glu Met Gln Ser Ser Asn Leu Tyr Met Ser Met 
    530                 535                 540                 


Ser Ser Trp Cys Tyr Thr His Ser Leu Asp Gly Ala Gly Leu Phe Leu 
545                 550                 555                 560 


Phe Asp His Ala Ala Glu Glu Tyr Glu His Ala Lys Lys Leu Ile Ile 
                565                 570                 575     


Phe Leu Asn Glu Asn Asn Val Pro Val Gln Leu Thr Ser Ile Ser Ala 
            580                 585                 590         


Pro Glu His Lys Phe Glu Gly Leu Thr Gln Ile Phe Gln Lys Ala Tyr 
        595                 600                 605             


Glu His Glu Gln His Ile Ser Glu Ser Ile Asn Asn Ile Val Asp His 
    610                 615                 620                 


Ala Ile Lys Ser Lys Asp His Ala Thr Phe Asn Phe Leu Gln Trp Tyr 
625                 630                 635                 640 


Val Ala Glu Gln His Glu Glu Glu Val Leu Phe Lys Asp Ile Leu Asp 
                645                 650                 655     


Lys Ile Glu Leu Ile Gly Asn Glu Asn His Gly Leu Tyr Leu Ala Asp 
            660                 665                 670         


Gln Tyr Val Lys Gly Ile Ala Lys Ser Arg Lys Ser 
        675                 680                 


<210>  15
<211>  685
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ConH3_ferritin

<400>  15

Met Lys Thr Ile Ile Ala Leu Ser Tyr Ile Phe Cys Leu Val Phe Ala 
1               5                   10                  15      


Gln Lys Leu Pro Gly Asn Asp Asn Ser Thr Ala Thr Leu Cys Leu Gly 
            20                  25                  30          


His His Ala Val Pro Asn Gly Thr Leu Val Lys Thr Ile Thr Asn Asp 
        35                  40                  45              


Gln Ile Glu Val Thr Asn Ala Thr Glu Leu Val Gln Ser Ser Ser Thr 
    50                  55                  60                  


Gly Arg Ile Cys Asp Ser Pro His Arg Ile Leu Asp Gly Thr Asn Cys 
65                  70                  75                  80  


Thr Leu Ile Asp Ala Leu Leu Gly Asp Pro His Cys Asp Gly Phe Gln 
                85                  90                  95      


Asn Lys Glu Trp Asp Leu Phe Val Glu Arg Ser Lys Ala Tyr Ser Asn 
            100                 105                 110         


Cys Tyr Pro Tyr Asp Val Pro Asp Tyr Ala Ser Leu Arg Ser Leu Val 
        115                 120                 125             


Ala Ser Ser Gly Thr Leu Glu Phe Asn Asn Glu Gly Phe Asn Trp Thr 
    130                 135                 140                 


Gly Val Thr Gln Asn Gly Gly Ser Ser Ala Cys Lys Arg Gly Ser Asp 
145                 150                 155                 160 


Lys Ser Phe Phe Ser Arg Leu Asn Trp Leu His Lys Leu Lys Tyr Lys 
                165                 170                 175     


Tyr Pro Ala Leu Asn Val Thr Met Pro Asn Asn Asp Lys Phe Asp Lys 
            180                 185                 190         


Leu Tyr Ile Trp Gly Val His His Pro Ser Thr Asp Ser Asp Gln Thr 
        195                 200                 205             


Ser Leu Tyr Val Gln Ala Ser Gly Arg Val Thr Val Ser Thr Lys Arg 
    210                 215                 220                 


Ser Gln Gln Thr Val Ile Pro Asn Ile Gly Ser Arg Pro Trp Val Arg 
225                 230                 235                 240 


Gly Leu Ser Ser Arg Ile Ser Ile Tyr Trp Thr Ile Val Lys Pro Gly 
                245                 250                 255     


Asp Ile Leu Leu Ile Asn Ser Thr Gly Asn Leu Ile Ala Pro Arg Gly 
            260                 265                 270         


Tyr Phe Lys Ile Arg Ser Gly Lys Ser Ser Ile Met Arg Ser Asp Ala 
        275                 280                 285             


Pro Ile Gly Thr Cys Asn Ser Glu Cys Ile Thr Pro Asn Gly Ser Ile 
    290                 295                 300                 


Pro Asn Asp Lys Pro Phe Gln Asn Val Asn Arg Ile Thr Tyr Gly Ala 
305                 310                 315                 320 


Cys Pro Arg Tyr Val Lys Gln Asn Thr Leu Lys Leu Ala Thr Gly Met 
                325                 330                 335     


Arg Asn Val Pro Glu Lys Gln Thr Arg Gly Ile Phe Gly Ala Ile Ala 
            340                 345                 350         


Gly Phe Ile Glu Asn Gly Trp Glu Gly Met Val Asp Gly Trp Tyr Gly 
        355                 360                 365             


Phe Arg His Gln Asn Ser Glu Gly Thr Gly Gln Ala Ala Asp Leu Lys 
    370                 375                 380                 


Ser Thr Gln Ala Ala Ile Asp Gln Ile Asn Gly Lys Leu Asn Arg Leu 
385                 390                 395                 400 


Ile Glu Lys Thr Asn Glu Lys Phe His Gln Ile Glu Lys Glu Phe Ser 
                405                 410                 415     


Glu Val Glu Gly Arg Ile Gln Asp Leu Glu Lys Tyr Val Glu Asp Thr 
            420                 425                 430         


Lys Ile Asp Leu Trp Ser Tyr Asn Ala Glu Leu Leu Val Ala Leu Glu 
        435                 440                 445             


Asn Gln His Thr Ile Asp Leu Thr Asp Ser Glu Met Asn Lys Leu Phe 
    450                 455                 460                 


Glu Arg Thr Arg Lys Gln Leu Arg Glu Asn Ala Glu Asp Met Gly Asn 
465                 470                 475                 480 


Gly Cys Phe Lys Ile Tyr His Lys Cys Asp Asn Ala Cys Ile Gly Ser 
                485                 490                 495     


Ile Arg Asn Gly Thr Tyr Asp His Asp Val Tyr Arg Asp Glu Ala Leu 
            500                 505                 510         


Asn Asn Arg Phe Gln Ile Lys Ser Gly Gly Asp Ile Ile Lys Leu Leu 
        515                 520                 525             


Asn Glu Gln Val Asn Lys Glu Met Gln Ser Ser Asn Leu Tyr Met Ser 
    530                 535                 540                 


Met Ser Ser Trp Cys Tyr Thr His Ser Leu Asp Gly Ala Gly Leu Phe 
545                 550                 555                 560 


Leu Phe Asp His Ala Ala Glu Glu Tyr Glu His Ala Lys Lys Leu Ile 
                565                 570                 575     


Ile Phe Leu Asn Glu Asn Asn Val Pro Val Gln Leu Thr Ser Ile Ser 
            580                 585                 590         


Ala Pro Glu His Lys Phe Glu Gly Leu Thr Gln Ile Phe Gln Lys Ala 
        595                 600                 605             


Tyr Glu His Glu Gln His Ile Ser Glu Ser Ile Asn Asn Ile Val Asp 
    610                 615                 620                 


His Ala Ile Lys Ser Lys Asp His Ala Thr Phe Asn Phe Leu Gln Trp 
625                 630                 635                 640 


Tyr Val Ala Glu Gln His Glu Glu Glu Val Leu Phe Lys Asp Ile Leu 
                645                 650                 655     


Asp Lys Ile Glu Leu Ile Gly Asn Glu Asn His Gly Leu Tyr Leu Ala 
            660                 665                 670         


Asp Gln Tyr Val Lys Gly Ile Ala Lys Ser Arg Lys Ser 
        675                 680                 685 


<210>  16
<211>  684
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Merck_pH1_Con_ferritin

<400>  16

Met Lys Ala Ile Leu Val Val Leu Leu Tyr Thr Phe Ala Thr Ala Asn 
1               5                   10                  15      


Ala Asp Thr Leu Cys Ile Gly Tyr His Ala Asn Asn Ser Thr Asp Thr 
            20                  25                  30          


Val Asp Thr Val Leu Glu Lys Asn Val Thr Val Thr His Ser Val Asn 
        35                  40                  45              


Leu Leu Glu Asp Lys His Asn Gly Lys Leu Cys Lys Leu Arg Gly Val 
    50                  55                  60                  


Ala Pro Leu His Leu Gly Lys Cys Asn Ile Ala Gly Trp Ile Leu Gly 
65                  70                  75                  80  


Asn Pro Glu Cys Glu Ser Leu Ser Thr Ala Ser Ser Trp Ser Tyr Ile 
                85                  90                  95      


Val Glu Thr Ser Ser Ser Asp Asn Gly Thr Cys Tyr Pro Gly Asp Phe 
            100                 105                 110         


Ile Asp Tyr Glu Glu Leu Arg Glu Gln Leu Ser Ser Val Ser Ser Phe 
        115                 120                 125             


Glu Arg Phe Glu Ile Phe Pro Lys Thr Ser Ser Trp Pro Asn His Asp 
    130                 135                 140                 


Ser Asn Lys Gly Val Thr Ala Ala Cys Pro His Ala Gly Ala Lys Ser 
145                 150                 155                 160 


Phe Tyr Lys Asn Leu Ile Trp Leu Val Lys Lys Gly Asn Ser Tyr Pro 
                165                 170                 175     


Lys Leu Ser Lys Ser Tyr Ile Asn Asp Lys Gly Lys Glu Val Leu Val 
            180                 185                 190         


Leu Trp Gly Ile His His Pro Ser Thr Ser Ala Asp Gln Gln Ser Leu 
        195                 200                 205             


Tyr Gln Asn Ala Asp Ala Tyr Val Phe Val Gly Thr Ser Arg Tyr Ser 
    210                 215                 220                 


Lys Lys Phe Lys Pro Glu Ile Ala Ile Arg Pro Lys Val Arg Asp Gln 
225                 230                 235                 240 


Glu Gly Arg Met Asn Tyr Tyr Trp Thr Leu Val Glu Pro Gly Asp Lys 
                245                 250                 255     


Ile Thr Phe Glu Ala Thr Gly Asn Leu Val Val Pro Arg Tyr Ala Phe 
            260                 265                 270         


Ala Met Glu Arg Asn Ala Gly Ser Gly Ile Ile Ile Ser Asp Thr Pro 
        275                 280                 285             


Val His Asp Cys Asn Thr Thr Cys Gln Thr Pro Lys Gly Ala Ile Asn 
    290                 295                 300                 


Thr Ser Leu Pro Phe Gln Asn Ile His Pro Ile Thr Ile Gly Lys Cys 
305                 310                 315                 320 


Pro Lys Tyr Val Lys Ser Thr Lys Leu Arg Leu Ala Thr Gly Leu Arg 
                325                 330                 335     


Asn Val Pro Ser Ile Gln Ser Arg Gly Leu Phe Gly Ala Ile Ala Gly 
            340                 345                 350         


Phe Ile Glu Gly Gly Trp Thr Gly Met Val Asp Gly Trp Tyr Gly Tyr 
        355                 360                 365             


His His Gln Asn Glu Gln Gly Ser Gly Tyr Ala Ala Asp Leu Lys Ser 
    370                 375                 380                 


Thr Gln Asn Ala Ile Asp Lys Ile Thr Asn Lys Val Asn Ser Val Ile 
385                 390                 395                 400 


Glu Lys Met Asn Thr Gln Phe Thr Ala Val Gly Lys Glu Phe Asn His 
                405                 410                 415     


Leu Glu Lys Arg Ile Glu Asn Leu Asn Lys Lys Val Asp Asp Gly Phe 
            420                 425                 430         


Leu Asp Ile Trp Thr Tyr Asn Ala Glu Leu Leu Val Leu Leu Glu Asn 
        435                 440                 445             


Glu Arg Thr Leu Asp Tyr His Asp Ser Asn Val Lys Asn Leu Tyr Glu 
    450                 455                 460                 


Lys Val Arg Ser Gln Leu Lys Asn Asn Ala Lys Glu Ile Gly Asn Gly 
465                 470                 475                 480 


Cys Phe Glu Phe Tyr His Lys Cys Asp Asn Thr Cys Met Glu Ser Val 
                485                 490                 495     


Lys Asn Gly Thr Tyr Asp Tyr Pro Lys Tyr Ser Glu Glu Ala Lys Leu 
            500                 505                 510         


Asn Arg Glu Glu Ile Asp Ser Gly Gly Asp Ile Ile Lys Leu Leu Asn 
        515                 520                 525             


Glu Gln Val Asn Lys Glu Met Gln Ser Ser Asn Leu Tyr Met Ser Met 
    530                 535                 540                 


Ser Ser Trp Cys Tyr Thr His Ser Leu Asp Gly Ala Gly Leu Phe Leu 
545                 550                 555                 560 


Phe Asp His Ala Ala Glu Glu Tyr Glu His Ala Lys Lys Leu Ile Ile 
                565                 570                 575     


Phe Leu Asn Glu Asn Asn Val Pro Val Gln Leu Thr Ser Ile Ser Ala 
            580                 585                 590         


Pro Glu His Lys Phe Glu Gly Leu Thr Gln Ile Phe Gln Lys Ala Tyr 
        595                 600                 605             


Glu His Glu Gln His Ile Ser Glu Ser Ile Asn Asn Ile Val Asp His 
    610                 615                 620                 


Ala Ile Lys Ser Lys Asp His Ala Thr Phe Asn Phe Leu Gln Trp Tyr 
625                 630                 635                 640 


Val Ala Glu Gln His Glu Glu Glu Val Leu Phe Lys Asp Ile Leu Asp 
                645                 650                 655     


Lys Ile Glu Leu Ile Gly Asn Glu Asn His Gly Leu Tyr Leu Ala Asp 
            660                 665                 670         


Gln Tyr Val Lys Gly Ile Ala Lys Ser Arg Lys Ser 
        675                 680                 


<210>  17
<211>  683
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Merck_sH1_Con_ferritin

<400>  17

Met Lys Val Lys Leu Leu Val Leu Leu Cys Thr Phe Thr Ala Thr Tyr 
1               5                   10                  15      


Ala Asp Thr Ile Cys Ile Gly Tyr His Ala Asn Asn Ser Thr Asp Thr 
            20                  25                  30          


Val Asp Thr Val Leu Glu Lys Asn Val Thr Val Thr His Ser Val Asn 
        35                  40                  45              


Leu Leu Glu Asp Ser His Asn Gly Lys Leu Cys Leu Leu Lys Gly Ile 
    50                  55                  60                  


Ala Pro Leu Gln Leu Gly Asn Cys Ser Val Ala Gly Trp Ile Leu Gly 
65                  70                  75                  80  


Asn Pro Glu Cys Glu Leu Leu Ile Ser Lys Glu Ser Trp Ser Tyr Ile 
                85                  90                  95      


Val Glu Thr Pro Asn Pro Glu Asn Gly Thr Cys Tyr Pro Gly Tyr Phe 
            100                 105                 110         


Ala Asp Tyr Glu Glu Leu Arg Glu Gln Leu Ser Ser Val Ser Ser Phe 
        115                 120                 125             


Glu Arg Phe Glu Ile Phe Pro Lys Glu Ser Ser Trp Pro Asn His Thr 
    130                 135                 140                 


Val Thr Gly Val Ser Ala Ser Cys Ser His Asn Gly Lys Ser Ser Phe 
145                 150                 155                 160 


Tyr Arg Asn Leu Leu Trp Leu Thr Gly Lys Asn Gly Leu Tyr Pro Asn 
                165                 170                 175     


Leu Ser Lys Ser Tyr Ala Asn Asn Lys Glu Lys Glu Val Leu Val Leu 
            180                 185                 190         


Trp Gly Val His His Pro Pro Asn Ile Gly Asp Gln Arg Ala Leu Tyr 
        195                 200                 205             


His Thr Glu Asn Ala Tyr Val Ser Val Val Ser Ser His Tyr Ser Arg 
    210                 215                 220                 


Arg Phe Thr Pro Glu Ile Ala Lys Arg Pro Lys Val Arg Asp Gln Glu 
225                 230                 235                 240 


Gly Arg Ile Asn Tyr Tyr Trp Thr Leu Leu Glu Pro Gly Asp Thr Ile 
                245                 250                 255     


Ile Phe Glu Ala Asn Gly Asn Leu Ile Ala Pro Arg Tyr Ala Phe Ala 
            260                 265                 270         


Leu Ser Arg Gly Phe Gly Ser Gly Ile Ile Thr Ser Asn Ala Pro Met 
        275                 280                 285             


Asp Glu Cys Asp Ala Lys Cys Gln Thr Pro Gln Gly Ala Ile Asn Ser 
    290                 295                 300                 


Ser Leu Pro Phe Gln Asn Val His Pro Val Thr Ile Gly Glu Cys Pro 
305                 310                 315                 320 


Lys Tyr Val Arg Ser Ala Lys Leu Arg Met Val Thr Gly Leu Arg Asn 
                325                 330                 335     


Ile Pro Ser Ile Gln Ser Arg Gly Leu Phe Gly Ala Ile Ala Gly Phe 
            340                 345                 350         


Ile Glu Gly Gly Trp Thr Gly Met Val Asp Gly Trp Tyr Gly Tyr His 
        355                 360                 365             


His Gln Asn Glu Gln Gly Ser Gly Tyr Ala Ala Asp Gln Lys Ser Thr 
    370                 375                 380                 


Gln Asn Ala Ile Asn Gly Ile Thr Asn Lys Val Asn Ser Val Ile Glu 
385                 390                 395                 400 


Lys Met Asn Thr Gln Phe Thr Ala Val Gly Lys Glu Phe Asn Lys Leu 
                405                 410                 415     


Glu Arg Arg Met Glu Asn Leu Asn Lys Lys Val Asp Asp Gly Phe Leu 
            420                 425                 430         


Asp Ile Trp Thr Tyr Asn Ala Glu Leu Leu Val Leu Leu Glu Asn Glu 
        435                 440                 445             


Arg Thr Leu Asp Phe His Asp Ser Asn Val Lys Asn Leu Tyr Glu Lys 
    450                 455                 460                 


Val Lys Ser Gln Leu Lys Asn Asn Ala Lys Glu Ile Gly Asn Gly Cys 
465                 470                 475                 480 


Phe Glu Phe Tyr His Lys Cys Asn Asp Glu Cys Met Glu Ser Val Lys 
                485                 490                 495     


Asn Gly Thr Tyr Asp Tyr Pro Lys Tyr Ser Glu Glu Ser Lys Leu Asn 
            500                 505                 510         


Arg Glu Lys Ile Asp Ser Gly Gly Asp Ile Ile Lys Leu Leu Asn Glu 
        515                 520                 525             


Gln Val Asn Lys Glu Met Gln Ser Ser Asn Leu Tyr Met Ser Met Ser 
    530                 535                 540                 


Ser Trp Cys Tyr Thr His Ser Leu Asp Gly Ala Gly Leu Phe Leu Phe 
545                 550                 555                 560 


Asp His Ala Ala Glu Glu Tyr Glu His Ala Lys Lys Leu Ile Ile Phe 
                565                 570                 575     


Leu Asn Glu Asn Asn Val Pro Val Gln Leu Thr Ser Ile Ser Ala Pro 
            580                 585                 590         


Glu His Lys Phe Glu Gly Leu Thr Gln Ile Phe Gln Lys Ala Tyr Glu 
        595                 600                 605             


His Glu Gln His Ile Ser Glu Ser Ile Asn Asn Ile Val Asp His Ala 
    610                 615                 620                 


Ile Lys Ser Lys Asp His Ala Thr Phe Asn Phe Leu Gln Trp Tyr Val 
625                 630                 635                 640 


Ala Glu Gln His Glu Glu Glu Val Leu Phe Lys Asp Ile Leu Asp Lys 
                645                 650                 655     


Ile Glu Leu Ile Gly Asn Glu Asn His Gly Leu Tyr Leu Ala Asp Gln 
            660                 665                 670         


Tyr Val Lys Gly Ile Ala Lys Ser Arg Lys Ser 
        675                 680             


<210>  18
<211>  684
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Cobra_P1_ferritin

<400>  18

Met Lys Ala Arg Leu Leu Val Leu Leu Cys Ala Leu Ala Ala Thr Asp 
1               5                   10                  15      


Ala Asp Thr Ile Cys Ile Gly Tyr His Ala Asn Asn Ser Thr Asp Thr 
            20                  25                  30          


Val Asp Thr Val Leu Glu Lys Asn Val Thr Val Thr His Ser Val Asn 
        35                  40                  45              


Leu Leu Glu Asp Ser His Asn Gly Lys Leu Cys Lys Leu Lys Gly Ile 
    50                  55                  60                  


Ala Pro Leu Gln Leu Gly Lys Cys Asn Ile Ala Gly Trp Leu Leu Gly 
65                  70                  75                  80  


Asn Pro Glu Cys Glu Ser Leu Leu Ser Ala Arg Ser Trp Ser Tyr Ile 
                85                  90                  95      


Val Glu Thr Pro Asn Ser Glu Asn Gly Thr Cys Tyr Pro Gly Asp Phe 
            100                 105                 110         


Ile Asp Tyr Glu Glu Leu Arg Glu Gln Leu Ser Ser Val Ser Ser Phe 
        115                 120                 125             


Glu Arg Phe Glu Ile Phe Pro Lys Glu Ser Ser Trp Pro Asn His Asn 
    130                 135                 140                 


Thr Thr Lys Gly Val Thr Ala Ala Cys Ser His Ala Gly Lys Ser Ser 
145                 150                 155                 160 


Phe Tyr Arg Asn Leu Leu Trp Leu Thr Lys Lys Gly Gly Ser Tyr Pro 
                165                 170                 175     


Lys Leu Ser Lys Ser Tyr Val Asn Asn Lys Gly Lys Glu Val Leu Val 
            180                 185                 190         


Leu Trp Gly Val His His Pro Ser Thr Ser Thr Asp Gln Gln Ser Leu 
        195                 200                 205             


Tyr Gln Asn Glu Asn Ala Tyr Val Ser Val Val Ser Ser Asn Tyr Asn 
    210                 215                 220                 


Arg Arg Phe Thr Pro Glu Ile Ala Glu Arg Pro Lys Val Arg Gly Gln 
225                 230                 235                 240 


Ala Gly Arg Met Asn Tyr Tyr Trp Thr Leu Leu Glu Pro Gly Asp Thr 
                245                 250                 255     


Ile Ile Phe Glu Ala Thr Gly Asn Leu Ile Ala Pro Trp Tyr Ala Phe 
            260                 265                 270         


Ala Leu Ser Arg Gly Ser Gly Ser Gly Ile Ile Thr Ser Asn Ala Ser 
        275                 280                 285             


Met His Glu Cys Asn Thr Lys Cys Gln Thr Pro Gln Gly Ala Ile Asn 
    290                 295                 300                 


Ser Ser Leu Pro Phe Gln Asn Ile His Pro Val Thr Ile Gly Glu Cys 
305                 310                 315                 320 


Pro Lys Tyr Val Arg Ser Thr Lys Leu Arg Met Val Thr Gly Leu Arg 
                325                 330                 335     


Asn Ile Pro Ser Ile Gln Ser Arg Gly Leu Phe Gly Ala Ile Ala Gly 
            340                 345                 350         


Phe Ile Glu Gly Gly Trp Thr Gly Met Ile Asp Gly Trp Tyr Gly Tyr 
        355                 360                 365             


His His Gln Asn Glu Gln Gly Ser Gly Tyr Ala Ala Asp Gln Lys Ser 
    370                 375                 380                 


Thr Gln Asn Ala Ile Asn Gly Ile Thr Asn Lys Val Asn Ser Val Ile 
385                 390                 395                 400 


Glu Lys Met Asn Thr Gln Phe Thr Ala Val Gly Lys Glu Phe Asn Asn 
                405                 410                 415     


Leu Glu Lys Arg Met Glu Asn Leu Asn Lys Lys Val Asp Asp Gly Phe 
            420                 425                 430         


Leu Asp Ile Trp Thr Tyr Asn Ala Glu Leu Leu Val Leu Leu Glu Asn 
        435                 440                 445             


Glu Arg Thr Leu Asp Phe His Asp Ser Asn Val Lys Asn Leu Tyr Glu 
    450                 455                 460                 


Lys Val Lys Ser Gln Leu Arg Asn Asn Ala Lys Glu Ile Gly Asn Gly 
465                 470                 475                 480 


Cys Phe Glu Phe Tyr His Lys Cys Asp Asn Glu Cys Met Glu Ser Val 
                485                 490                 495     


Lys Asn Gly Thr Tyr Asp Tyr Pro Lys Tyr Ser Glu Glu Ser Lys Leu 
            500                 505                 510         


Asn Arg Glu Lys Ile Asp Ser Gly Gly Asp Ile Ile Lys Leu Leu Asn 
        515                 520                 525             


Glu Gln Val Asn Lys Glu Met Gln Ser Ser Asn Leu Tyr Met Ser Met 
    530                 535                 540                 


Ser Ser Trp Cys Tyr Thr His Ser Leu Asp Gly Ala Gly Leu Phe Leu 
545                 550                 555                 560 


Phe Asp His Ala Ala Glu Glu Tyr Glu His Ala Lys Lys Leu Ile Ile 
                565                 570                 575     


Phe Leu Asn Glu Asn Asn Val Pro Val Gln Leu Thr Ser Ile Ser Ala 
            580                 585                 590         


Pro Glu His Lys Phe Glu Gly Leu Thr Gln Ile Phe Gln Lys Ala Tyr 
        595                 600                 605             


Glu His Glu Gln His Ile Ser Glu Ser Ile Asn Asn Ile Val Asp His 
    610                 615                 620                 


Ala Ile Lys Ser Lys Asp His Ala Thr Phe Asn Phe Leu Gln Trp Tyr 
625                 630                 635                 640 


Val Ala Glu Gln His Glu Glu Glu Val Leu Phe Lys Asp Ile Leu Asp 
                645                 650                 655     


Lys Ile Glu Leu Ile Gly Asn Glu Asn His Gly Leu Tyr Leu Ala Asp 
            660                 665                 670         


Gln Tyr Val Lys Gly Ile Ala Lys Ser Arg Lys Ser 
        675                 680                 


<210>  19
<211>  684
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Cobra_X3_ferritin

<400>  19

Met Glu Ala Arg Leu Leu Val Leu Leu Cys Ala Phe Ala Ala Thr Asn 
1               5                   10                  15      


Ala Asp Thr Ile Cys Ile Gly Tyr His Ala Asn Asn Ser Thr Asp Thr 
            20                  25                  30          


Val Asp Thr Val Leu Glu Lys Asn Val Thr Val Thr His Ser Val Asn 
        35                  40                  45              


Leu Leu Glu Asp Ser His Asn Gly Lys Leu Cys Arg Leu Lys Gly Ile 
    50                  55                  60                  


Ala Pro Leu Gln Leu Gly Asn Cys Ser Val Ala Gly Trp Ile Leu Gly 
65                  70                  75                  80  


Asn Pro Glu Cys Glu Ser Leu Phe Ser Lys Glu Ser Trp Ser Tyr Ile 
                85                  90                  95      


Ala Glu Thr Pro Asn Pro Glu Asn Gly Thr Cys Tyr Pro Gly Tyr Phe 
            100                 105                 110         


Ala Asp Tyr Glu Glu Leu Arg Glu Gln Leu Ser Ser Val Ser Ser Phe 
        115                 120                 125             


Glu Arg Phe Glu Ile Phe Pro Lys Glu Ser Ser Trp Pro Asn His Thr 
    130                 135                 140                 


Val Thr Lys Gly Val Thr Ala Ser Cys Ser His Asn Gly Lys Ser Ser 
145                 150                 155                 160 


Phe Tyr Arg Asn Leu Leu Trp Leu Thr Glu Lys Asn Gly Leu Tyr Pro 
                165                 170                 175     


Asn Leu Ser Lys Ser Tyr Val Asn Asn Lys Glu Lys Glu Val Leu Val 
            180                 185                 190         


Leu Trp Gly Val His His Pro Ser Asn Ile Gly Asp Gln Arg Ala Ile 
        195                 200                 205             


Tyr His Thr Glu Asn Ala Tyr Val Ser Val Val Ser Ser His Tyr Ser 
    210                 215                 220                 


Arg Arg Phe Thr Pro Glu Ile Ala Lys Arg Pro Lys Val Arg Asp Gln 
225                 230                 235                 240 


Glu Gly Arg Ile Asn Tyr Tyr Trp Thr Leu Leu Glu Pro Gly Asp Thr 
                245                 250                 255     


Ile Ile Phe Glu Ala Asn Gly Asn Leu Ile Ala Pro Trp Tyr Ala Phe 
            260                 265                 270         


Ala Leu Ser Arg Gly Phe Gly Ser Gly Ile Ile Thr Ser Asn Ala Ser 
        275                 280                 285             


Met Asp Glu Cys Asp Ala Lys Cys Gln Thr Pro Gln Gly Ala Ile Asn 
    290                 295                 300                 


Ser Ser Leu Pro Phe Gln Asn Val His Pro Val Thr Ile Gly Glu Cys 
305                 310                 315                 320 


Pro Lys Tyr Val Arg Ser Thr Lys Leu Arg Met Val Thr Gly Leu Arg 
                325                 330                 335     


Asn Ile Pro Ser Ile Gln Ser Arg Gly Leu Phe Gly Ala Ile Ala Gly 
            340                 345                 350         


Phe Ile Glu Gly Gly Trp Thr Gly Met Ile Asp Gly Trp Tyr Gly Tyr 
        355                 360                 365             


His His Gln Asn Glu Gln Gly Ser Gly Tyr Ala Ala Asp Gln Lys Ser 
    370                 375                 380                 


Thr Gln Asn Ala Ile Asn Gly Ile Thr Asn Lys Val Asn Ser Val Ile 
385                 390                 395                 400 


Glu Lys Met Asn Thr Gln Phe Thr Ala Val Gly Lys Glu Phe Asn Lys 
                405                 410                 415     


Leu Glu Arg Arg Met Glu Asn Leu Asn Lys Lys Val Asp Asp Gly Phe 
            420                 425                 430         


Leu Asp Ile Trp Thr Tyr Asn Ala Glu Leu Leu Val Leu Leu Glu Asn 
        435                 440                 445             


Glu Arg Thr Leu Asp Phe His Asp Ser Asn Val Lys Asn Leu Tyr Glu 
    450                 455                 460                 


Lys Val Lys Ser Gln Leu Lys Asn Asn Ala Lys Glu Ile Gly Asn Gly 
465                 470                 475                 480 


Cys Phe Glu Phe Tyr His Lys Cys Asn Asn Glu Cys Met Glu Ser Val 
                485                 490                 495     


Lys Asn Gly Thr Tyr Asp Tyr Pro Lys Tyr Ser Glu Glu Ser Lys Leu 
            500                 505                 510         


Asn Arg Glu Lys Ile Asp Ser Gly Gly Asp Ile Ile Lys Leu Leu Asn 
        515                 520                 525             


Glu Gln Val Asn Lys Glu Met Gln Ser Ser Asn Leu Tyr Met Ser Met 
    530                 535                 540                 


Ser Ser Trp Cys Tyr Thr His Ser Leu Asp Gly Ala Gly Leu Phe Leu 
545                 550                 555                 560 


Phe Asp His Ala Ala Glu Glu Tyr Glu His Ala Lys Lys Leu Ile Ile 
                565                 570                 575     


Phe Leu Asn Glu Asn Asn Val Pro Val Gln Leu Thr Ser Ile Ser Ala 
            580                 585                 590         


Pro Glu His Lys Phe Glu Gly Leu Thr Gln Ile Phe Gln Lys Ala Tyr 
        595                 600                 605             


Glu His Glu Gln His Ile Ser Glu Ser Ile Asn Asn Ile Val Asp His 
    610                 615                 620                 


Ala Ile Lys Ser Lys Asp His Ala Thr Phe Asn Phe Leu Gln Trp Tyr 
625                 630                 635                 640 


Val Ala Glu Gln His Glu Glu Glu Val Leu Phe Lys Asp Ile Leu Asp 
                645                 650                 655     


Lys Ile Glu Leu Ile Gly Asn Glu Asn His Gly Leu Tyr Leu Ala Asp 
            660                 665                 670         


Gln Tyr Val Lys Gly Ile Ala Lys Ser Arg Lys Ser 
        675                 680                 


<210>  20
<211>  498
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Wildtype Sequence of Nucleoprotein

<400>  20

Met Ala Ser Gln Gly Thr Lys Arg Ser Tyr Glu Gln Met Glu Thr Asp 
1               5                   10                  15      


Gly Glu Arg Gln Asn Ala Thr Glu Ile Arg Ala Ser Val Gly Lys Met 
            20                  25                  30          


Ile Asp Gly Ile Gly Arg Phe Tyr Ile Gln Met Cys Thr Glu Leu Lys 
        35                  40                  45              


Leu Ser Asp Tyr Glu Gly Arg Leu Ile Gln Asn Ser Leu Thr Ile Glu 
    50                  55                  60                  


Arg Met Val Leu Ser Ala Phe Asp Glu Arg Arg Asn Arg Tyr Leu Glu 
65                  70                  75                  80  


Glu His Pro Ser Ala Gly Lys Asp Pro Lys Lys Thr Gly Gly Pro Ile 
                85                  90                  95      


Tyr Lys Arg Val Asp Gly Arg Trp Met Arg Glu Leu Val Leu Tyr Asp 
            100                 105                 110         


Lys Glu Glu Ile Arg Arg Ile Trp Arg Gln Ala Asn Asn Gly Asp Asp 
        115                 120                 125             


Ala Thr Ala Gly Leu Thr His Met Met Ile Trp His Ser Asn Leu Asn 
    130                 135                 140                 


Asp Thr Thr Tyr Gln Arg Thr Arg Ala Leu Val Arg Thr Gly Met Asp 
145                 150                 155                 160 


Pro Arg Met Cys Ser Leu Met Gln Gly Ser Thr Leu Pro Arg Arg Ser 
                165                 170                 175     


Gly Ala Ala Gly Ala Ala Val Lys Gly Ile Gly Thr Met Val Met Glu 
            180                 185                 190         


Leu Ile Arg Met Ile Lys Arg Gly Ile Asn Asp Arg Asn Phe Trp Arg 
        195                 200                 205             


Gly Glu Asn Gly Arg Lys Thr Arg Ser Ala Tyr Glu Arg Met Cys Asn 
    210                 215                 220                 


Ile Leu Lys Gly Lys Phe Gln Thr Ala Ala Gln Arg Ala Met Met Asp 
225                 230                 235                 240 


Gln Val Arg Glu Ser Arg Asn Pro Gly Asn Ala Glu Ile Glu Asp Leu 
                245                 250                 255     


Ile Phe Ser Ala Arg Ser Ala Leu Ile Leu Arg Gly Ser Val Ala His 
            260                 265                 270         


Lys Ser Cys Leu Pro Ala Cys Val Tyr Gly Pro Ala Val Ser Ser Gly 
        275                 280                 285             


Tyr Asn Phe Glu Lys Glu Gly Tyr Ser Leu Val Gly Ile Asp Pro Phe 
    290                 295                 300                 


Lys Leu Leu Gln Asn Ser Gln Val Tyr Ser Leu Ile Arg Pro Asn Glu 
305                 310                 315                 320 


Asn Pro Ala His Lys Ser Gln Leu Val Trp Met Ala Cys His Ser Ala 
                325                 330                 335     


Ala Phe Glu Asp Leu Arg Leu Leu Ser Phe Ile Arg Gly Thr Lys Val 
            340                 345                 350         


Ser Pro Arg Gly Lys Leu Ser Thr Arg Gly Val Gln Ile Ala Ser Asn 
        355                 360                 365             


Glu Asn Met Asp Asn Met Glu Ser Ser Thr Leu Glu Leu Arg Ser Arg 
    370                 375                 380                 


Tyr Trp Ala Ile Arg Thr Arg Ser Gly Gly Asn Thr Asn Gln Gln Arg 
385                 390                 395                 400 


Ala Ser Ala Gly Gln Ile Ser Val Gln Pro Thr Phe Ser Val Gln Arg 
                405                 410                 415     


Asn Leu Pro Phe Glu Lys Ser Thr Val Met Ala Ala Phe Thr Gly Asn 
            420                 425                 430         


Thr Glu Gly Arg Thr Ser Asp Met Arg Ala Glu Ile Ile Arg Met Met 
        435                 440                 445             


Glu Gly Ala Lys Pro Glu Glu Val Ser Phe Arg Gly Arg Gly Val Phe 
    450                 455                 460                 


Glu Leu Ser Asp Glu Lys Ala Thr Asn Pro Ile Val Pro Ser Phe Asp 
465                 470                 475                 480 


Met Ser Asn Glu Gly Ser Tyr Phe Phe Gly Asp Asn Ala Glu Glu Tyr 
                485                 490                 495     


Asp Asn 
        


<210>  21
<211>  573
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  BHA10-2

<400>  21
atggagaccc ccgcccagct gctgttcctg ctgctgctgt ggctgcccga caccaccggc       60

cacgtggtga agaccgccac ccagggcgag gtgaacgtga ccggcgtgat ccccctgacc      120

accaccccca ccggcagcgc caacaagagc aagccctact acaccggcga gcacgccaag      180

gccaccggca actgccccat ctgggtgaag acccccctga agctggccaa cggcaccaag      240

tacggcagcg ccggcagcgc cacccaggag gccatcaaca agatcaccaa gaacctgaac      300

agcctgagcg agctggaggt gaagaacctg cagaggctga gcggcgccag cgacgagacc      360

cacaacgaga tcctggagct ggacgagaag gtggacgacc tgagggccga caccatcagc      420

agccagatcg agctggccgt gctgctgagc aacgagggca tcatcaacag cgaggacgag      480

ggcaccggcg gcggctacat ccccgaggcc cccagggacg gccaggccta cgtgaggaag      540

gacggcgagt gggtgctgct gagcaccttc ctg                                   573


<210>  22
<211>  480
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  BHA10-3

<400>  22
atggagaccc ccgcccagct gctgttcctg ctgctgctgt ggctgcccga caccaccggc       60

cacgtggtga agaccgccac ccagggcgag gtgaacgtga ccggcgtgat ccccctgacc      120

accaccccca ccggcagcgc caacaagagc aagccctact acaccggcga gcacgccaag      180

gccaccggca actgccccat ctgggtgaag acccccctga agctggccaa cggcaccaag      240

tacggcagcg ccggcagcgc cacccaggag gccatcaaca agatcaccaa gaacctgaac      300

agcctgagcg agctggaggt gaagaacctg cagaggctga gctgcgccag cgacgagacc      360

cacaactgca tcctggagct ggacgagaag gtggacgacc tgagggccga caccatcagc      420

agcctgatcg agctggccgt gctgctgagc aacgagggca tcatcaacag cgaggacgag      480


<210>  23
<211>  780
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  NIHGen6HASS-TM

<400>  23
atggagaccc ccgcccagct gctgttcctg ctgctgctgt ggctgcccga caccaccggc       60

gacaccatct gcatcggcta ccacgccaac aacagcaccg acaccgtgga caccgtgctg      120

gagaagaacg tgaccgtgac ccacagcgtg aacctgggca gcggcctgag gatggtgacc      180

ggcctgagga acatccccca gagggagacc aggggcctgt tcggcgccat cgccggcttc      240

atcgagggcg gctggaccgg catggtggac ggctggtacg gctaccacca ccagaacgag      300

cagggcagcg gctacgccgc cgaccagaag agcacccaga acgccatcaa cggcatcacc      360

aacatggtga acagcgtgat cgagaagatg ggcagcggcg gcagcggcac cgacctggcc      420

gagctgctgg tgctgctgct gaacgagagg accctggact tccacgacag caacgtgaag      480

aacctgtacg agaaggtgaa gagccagctg aagaacaacg ccaaggagat cggcaacggc      540

tgcttcgagt tctaccacaa gtgcaacaac gagtgcatgg agagcgtgaa gaacggcacc      600

tacgactacc ccaagtacag cgaggagagc aagctgaaca gggagaagat cgaccagggc      660

accggcggca tcctggccat ctacagcacc gtggccagca gcctggtgct gctggtgagc      720

ctgggcgcca tcagcttctg gatgtgcagc aacggcagcc tgcagtgcag aatctgcatc      780


<210>  24
<211>  798
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  NIHGen6HASS-TM2

<400>  24
atggagaccc ccgcccagct gctgttcctg ctgctgctgt ggctgcccga caccaccggc       60

gacaccatct gcatcggcta ccacgccaac aacagcaccg acaccgtgga caccgtgctg      120

gagaagaacg tgaccgtgac ccacagcgtg aacctgggca gcggcctgag gatggtgacc      180

ggcctgagga acatccccca gagggagacc aggggcctgt tcggcgccat cgccggcttc      240

atcgagggcg gctggaccgg catggtggac ggctggtacg gctaccacca ccagaacgag      300

cagggcagcg gctacgccgc cgaccagaag agcacccaga acgccatcaa cggcatcacc      360

aacatggtga acagcgtgat cgagaagatg ggcagcggcg gcagcggcac cgacctggcc      420

gagctgctgg tgctgctgct gaacgagagg accctggact tccacgacag caacgtgaag      480

aacctgtacg agaaggtgaa gagccagctg aagaacaacg ccaaggagat cggcaacggc      540

tgcttcgagt tctaccacaa gtgcaacaac gagtgcatgg agagcgtgaa gaacggcacc      600

tacgactacc ccaagtacag cgaggagagc aagctgaaca gggagaagat cgacggagtg      660

aaattggaat caatgggggt ctatcagatc ctggccatct acagcaccgt ggccagcagc      720

ctggtgctgc tggtgagcct gggcgccatc agcttctgga tgtgcagcaa cggcagcctg      780

cagtgcagaa tctgcatc                                                    798


<210>  25
<211>  744
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  NIHGen6HASS-foldon

<400>  25
atggagaccc ccgcccagct gctgttcctg ctgctgctgt ggctgcccga caccaccggc       60

gacaccatct gcatcggcta ccacgccaac aacagcaccg acaccgtgga caccgtgctg      120

gagaagaacg tgaccgtgac ccacagcgtg aacctgggca gcggcctgag gatggtgacc      180

ggcctgagga acatccccca gagggagacc aggggcctgt tcggcgccat cgccggcttc      240

atcgagggcg gctggaccgg catggtggac ggctggtacg gctaccacca ccagaacgag      300

cagggcagcg gctacgccgc cgaccagaag agcacccaga acgccatcaa cggcatcacc      360

aacatggtga acagcgtgat cgagaagatg ggcagcggcg gcagcggcac cgacctggcc      420

gagctgctgg tgctgctgct gaacgagagg accctggact tccacgacag caacgtgaag      480

aacctgtacg agaaggtgaa gagccagctg aagaacaacg ccaaggagat cggcaacggc      540

tgcttcgagt tctaccacaa gtgcaacaac gagtgcatgg agagcgtgaa gaacggcacc      600

tacgactacc ccaagtacag cgaggagagc aagctgaaca gggagaagat cgaccccggc      660

agcggctaca tccccgaggc ccccagggac ggccaggcct acgtgaggaa ggacggcgag      720

tgggtgctgc tgagcacctt cctg                                             744


<210>  26
<211>  1698
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ConH1

<400>  26
atgaaggcca agctgctggt gctgctgtgc gccttcaccg ccaccgacgc cgacaccatc       60

tgcattggct accatgccaa caacagcacc gacaccgtgg acaccgtgct cgagaagaac      120

gtgaccgtga cccactccgt gaatttgttg gaggacagcc acaacggcaa gctgtgtaag      180

ctgaagggca tcgcccccct gcagctgggc aagtgcaaca tcgccggctg gatcttgggc      240

aatcccgagt gcgaaagcct gatctccaag agaagctgga gctacatcgt ggagactccc      300

aacagcgaaa acggcacctg ctaccccggc gacttcgctg actacgagga actgagagag      360

cagctgagca gcgtgagcag ctttgagaga ttcgagatct tccccaaaga gagcagctgg      420

cccaaccaca acgtaaccaa gggcgtgaca gccgcctgca gccacgccgg taagagcagc      480

ttctacagaa acctgctgtg gctgacagag aagaacggca gctaccccaa gctgagcaag      540

agctatgtga acaacaagga gaaggaggtg ctggtcctgt ggggcgtaca ccaccccagc      600

aacattaccg atcagagaac cctgtaccag aacgagaatg cctacgtgag cgtggtgagc      660

agccactaca acagaagatt cacccccgag attgccaaga gaccgaaagt gagaggccag      720

gccggaagaa tcaactacta ctggaccctg ctggagcccg gcgacaccat catcttcgag      780

gccaacggca acctgatcgc cccctggtat gccttcgccc tgagcagagg cttcggaagc      840

ggcatcatca catccaacgc ccccatgcat gaatgcgaca caaagtgtca gaccccccag      900

ggcgccatca acagcagcct gcccttccag aacgtgcacc ctgtgaccat cggcgagtgc      960

cccaagtacg tgagaagcac caagctgaga atggtgaccg gcctgagaaa tatccccagt     1020

atccagagca gaggcctgtt cggcgccatc gccggcttca tcgagggcgg ctggaccggc     1080

atgatcgacg gctggtacgg ctaccaccac cagaacgagc agggcagcgg ctacgccgcc     1140

gaccagaaga gcactcagaa cgccatcaac ggcatcacca acaaggtgaa cagcgtgatc     1200

gagaagatga acacacagtt caccgccgtg ggcaaagagt tcaataagct cgagaagaga     1260

atggaaaacc tgaacaagaa ggttgacgac ggtttcctgg atatctggac ctacaacgcc     1320

gagctgcttg tgctgctgga gaacgagcgt accctggact ttcacgactc gaacgtgaag     1380

aacctgtacg aaaaggtgaa gtcccagctg aagaacaacg ccaaagaaat tggcaacggc     1440

tgcttcgagt tctaccacaa gtgtaacaac gagtgcatgg agagcgtgaa gaacggcacc     1500

tacgactatc ccaagtacag cgaggagagc aagctaaaca gagagaagat tgacggcgtg     1560

aaactggagt caatgggcgt gtaccagatc ctggccatct acagcaccgt ggccagcagc     1620

ctcgtgctgc tggtgagcct gggcgccata agcttctgga tgtgtagcaa cggcagcctg     1680

cagtgcagaa tctgcatc                                                   1698


<210>  27
<211>  1698
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ConH3

<400>  27
atgaagacca tcatcgctct gagctacata ttctgcctgg tgttcgccca gaagctgccc       60

ggcaacgaca acagcaccgc caccctgtgc ctgggccatc acgcagtgcc aaacggcacc      120

ttagttaaga ccatcaccaa cgaccagatc gaggtgacca acgccaccga gctggtgcag      180

agcagtagca ccggcagaat ctgcgacagc ccccaccgga tccttgacgg cactaactgc      240

accctgatcg acgccctgct gggcgacccc cactgcgacg ggttccagaa caaggagtgg      300

gacctgttcg tggagagaag caaggcctac agcaactgct acccctacga tgtgcccgac      360

tacgccagcc tgagatctct tgtggctagc agcggcaccc tggagttcaa caatgagggc      420

ttcaattgga caggcgtgac ccagaacggc ggcagcagcg cctgcaagag aggcagcgac      480

aagagcttct tcagcagact gaactggctg cacaagctga agtacaagta tcccgccctg      540

aacgtgacca tgcccaataa cgacaagttc gataagctgt atatttgggg cgtgcaccac      600

cccagcaccg acagcgacca gacctccctg tacgtccagg cgagcggcag agtgaccgtg      660

agcaccaaac ggagccagca aaccgtgatc cccaacatcg gcagcagacc ttgggtcaga      720

ggactgagca gcagaatcag catctactgg accatcgtga agcctggcga catcttgctg      780

atcaatagca ccggcaacct gatcgccccc agaggctact tcaagatcag aagcggcaag      840

agctcaatca tgagaagcga cgcccccata ggcacctgca acagcgagtg catcaccccg      900

aacggcagca tccccaacga caagcccttc cagaacgtga acagaatcac atacggcgcc      960

tgccccaggt acgtaaagca aaacaccctg aagctggcca ccggcatgag aaacgtaccc     1020

gagaagcaga ccagaggcat cttcggcgcc atcgcgggct tcatcgagaa tggctgggaa     1080

ggcatggtgg acggctggta cggcttcaga catcagaaca gcgagggcac cggccaggcc     1140

gccgacctga aaagcaccca ggccgccatc gaccagatca acggcaagct gaacagactg     1200

atcgaaaaga ccaacgagaa gttccaccag atcgagaagg agttcagcga agtggaggga     1260

agaatacagg acctggagaa atacgtggag gacaccaaga tcgacctgtg gtcgtacaac     1320

gccgagctgc tggtggccct ggaaaaccag cacaccattg acctgaccga tagcgagatg     1380

aacaagctgt tcgagagaac cagaaaacag ctgagagaga acgccgagga catgggcaac     1440

ggctgcttta agatctacca caagtgcgac aacgcctgca tcggcagcat cagaaacggc     1500

acctacgacc acgacgtgta cagagacgag gccctgaaca acagattcca gatcaagggc     1560

gtggagctga agagcggcta caaggactgg atcctgtgga tcagcttcgc catcagctgt     1620

ttcctgcttt gcgtagtgct gctgggcttc atcatgtggg cctgccagaa gggcaatatc     1680

agatgcaaca tttgcatc                                                   1698


<210>  28
<211>  1698
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  MRK_pH1_Con

<400>  28
atgaaggcca tcctggtggt gctgctgtac accttcgcca cggccaacgc tgacaccctg       60

tgcatcggat accacgcgaa caacagcacc gacaccgttg acaccgtgct ggagaagaac      120

gtgaccgtga cccacagcgt gaacctcctg gaagacaagc acaacggcaa gctgtgcaag      180

ctgagaggcg tggcccccct gcacctgggc aagtgcaaca tcgccggctg gatcttaggc      240

aaccccgagt gcgagagcct gagcaccgcc agcagctgga gctacattgt ggagaccagc      300

agcagcgaca acggcacctg ctaccccggc gacttcatcg actacgagga gctgagagag      360

cagctgagca gcgtgagcag cttcgagaga ttcgagatct tccccaagac ctcaagctgg      420

cccaaccacg acagcaataa gggcgtgact gccgcctgcc cccacgccgg cgccaagagc      480

ttctacaaga acctgatctg gctggtgaag aaaggcaata gctaccccaa gctgagcaag      540

tcctatatca acgacaaggg caaggaggtg ttggttctgt ggggcatcca tcaccccagc      600

accagtgctg atcagcaaag cctgtaccaa aacgccgatg cctacgtgtt cgtgggcacc      660

tcaagataca gcaagaagtt caagcccgag atcgccatca gacccaaggt gagagaccag      720

gagggtagaa tgaactacta ctggaccctc gtggagccgg gcgacaagat caccttcgag      780

gccaccggca acctggtggt gcccagatac gccttcgcca tggagagaaa tgccggcagc      840

gggatcatca tctcggacac ccccgtgcac gattgtaaca ccacctgcca gacccccaag      900

ggcgccatca acacctccct gcccttccag aacatccacc ccatcaccat cggcaagtgc      960

cccaagtacg tgaagagcac caagctgaga ctggcgaccg gactgagaaa cgtgcccagc     1020

atccagtcaa gaggcctgtt cggcgccatc gccggcttca tcgagggcgg ctggacaggc     1080

atggtggacg gctggtacgg ctaccaccac cagaacgagc agggcagcgg atacgccgcc     1140

gacctgaaga gcacacaaaa cgccatcgac aagatcacca acaaggtgaa cagcgtgatc     1200

gaaaagatga acacccagtt caccgccgtg ggcaaggagt tcaaccacct ggagaagaga     1260

atcgagaacc tgaacaagaa agtggacgac ggcttcctgg acatctggac ctacaacgcc     1320

gagctgctgg tcctgctgga gaacgagaga accctggact accatgacag caacgtgaag     1380

aacctgtacg agaaggtgag aagccagctg aagaacaacg ccaaggagat aggcaacggc     1440

tgcttcgagt tctaccacaa gtgcgacaac acctgcatgg agagcgtgaa gaacggcacc     1500

tacgactacc caaagtatag cgaggaggca aagctgaaca gagaggagat cgacggcgtg     1560

aagctggaga gcaccaggat ctatcaaatc ctggccatat acagcaccgt ggccagcagc     1620

ctggtgttag tggtgagcct gggcgccatc agcttctgga tgtgtagcaa cggcagcctg     1680

cagtgcagaa tctgcatc                                                   1698


<210>  29
<211>  1587
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  MRK_pH1_Con

<400>  29
atgaaggcca tcctggtggt gctgctgtac accttcgcca cggccaacgc tgacaccctg       60

tgcatcggat accacgcgaa caacagcacc gacaccgttg acaccgtgct ggagaagaac      120

gtgaccgtga cccacagcgt gaacctcctg gaagacaagc acaacggcaa gctgtgcaag      180

ctgagaggcg tggcccccct gcacctgggc aagtgcaaca tcgccggctg gatcttaggc      240

aaccccgagt gcgagagcct gagcaccgcc agcagctgga gctacattgt ggagaccagc      300

agcagcgaca acggcacctg ctaccccggc gacttcatcg actacgagga gctgagagag      360

cagctgagca gcgtgagcag cttcgagaga ttcgagatct tccccaagac ctcaagctgg      420

cccaaccacg acagcaataa gggcgtgact gccgcctgcc cccacgccgg cgccaagagc      480

ttctacaaga acctgatctg gctggtgaag aaaggcaata gctaccccaa gctgagcaag      540

tcctatatca acgacaaggg caaggaggtg ttggttctgt ggggcatcca tcaccccagc      600

accagtgctg atcagcaaag cctgtaccaa aacgccgatg cctacgtgtt cgtgggcacc      660

tcaagataca gcaagaagtt caagcccgag atcgccatca gacccaaggt gagagaccag      720

gagggtagaa tgaactacta ctggaccctc gtggagccgg gcgacaagat caccttcgag      780

gccaccggca acctggtggt gcccagatac gccttcgcca tggagagaaa tgccggcagc      840

gggatcatca tctcggacac ccccgtgcac gattgtaaca ccacctgcca gacccccaag      900

ggcgccatca acacctccct gcccttccag aacatccacc ccatcaccat cggcaagtgc      960

cccaagtacg tgaagagcac caagctgaga ctggcgaccg gactgagaaa cgtgcccagc     1020

atccagtcaa gaggcctgtt cggcgccatc gccggcttca tcgagggcgg ctggacaggc     1080

atggtggacg gctggtacgg ctaccaccac cagaacgagc agggcagcgg atacgccgcc     1140

gacctgaaga gcacacaaaa cgccatcgac aagatcacca acaaggtgaa cagcgtgatc     1200

gaaaagatga acacccagtt caccgccgtg ggcaaggagt tcaaccacct ggagaagaga     1260

atcgagaacc tgaacaagaa agtggacgac ggcttcctgg acatctggac ctacaacgcc     1320

gagctgctgg tcctgctgga gaacgagaga accctggact accatgacag caacgtgaag     1380

aacctgtacg agaaggtgag aagccagctg aagaacaacg ccaaggagat aggcaacggc     1440

tgcttcgagt tctaccacaa gtgcgacaac acctgcatgg agagcgtgaa gaacggcacc     1500

tacgactacc caaagtatag cgaggaggca aagctgaaca gagaggagat cgacggcgtg     1560

aagctggaga gcaccaggat ctatcaa                                         1587


<210>  30
<211>  1695
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  MRK_sH1_Con

<400>  30
atgaaggtga agctgctggt gctgctgtgt accttcactg ccacttacgc cgacaccatt       60

tgcatcggct accacgccaa caacagcacc gataccgtgg acaccgtgct ggagaagaac      120

gtcaccgtga cccacagcgt gaacctgctg gaggatagcc ataacggcaa gctgtgcctg      180

ctgaagggaa tcgcccccct gcagctcggc aactgcagcg tggccggctg gattctgggc      240

aaccccgagt gcgaactgct gattagcaaa gagtcctgga gctacatcgt ggaaaccccg      300

aatcccgaga acggcacctg ctaccccggc tacttcgccg actacgaaga gctaagagag      360

cagctgagta gcgtgagctc attcgagaga ttcgagatct ttcccaagga gtctagctgg      420

cccaatcaca ccgtgaccgg cgtgagcgcc agctgtagcc acaacggcaa gagcagcttc      480

tacagaaacc tgctgtggct gaccggcaag aacggactgt accctaacct gagcaagagc      540

tacgcgaaca ataaggagaa ggaggtgcta gtgctgtggg gcgtgcacca cccccccaac      600

atcggcgacc agagagccct gtaccacacc gagaacgcct acgtgagcgt ggtgagcagc      660

cactatagca gaagattcac ccccgagatc gccaagagac caaaggtgag agatcaggaa      720

ggaagaataa actactactg gaccctcctg gagcccggcg acaccatcat cttcgaggct      780

aacggcaacc tgatcgcccc cagatacgcc ttcgccctga gcagaggctt cggcagcggc      840

atcatcacca gcaatgcccc catggatgag tgcgacgcca agtgccagac cccccagggc      900

gccatcaact cgagcctgcc cttccagaat gtgcaccccg tgaccatcgg cgagtgcccc      960

aagtacgtga gaagcgccaa gctgagaatg gtgaccggcc tgagaaacat cccaagcatc     1020

cagagcagag ggctgttcgg cgccatcgct ggcttcatcg agggcggctg gaccggcatg     1080

gtggacggct ggtacggtta tcaccaccag aacgagcagg gcagcggcta cgccgccgac     1140

cagaagagca cccagaacgc catcaacggc attacaaaca aggtgaacag cgttatcgag     1200

aagatgaaca cccaattcac cgccgtgggc aaggagttca acaagctgga gagaagaatg     1260

gagaacctga acaagaaggt ggacgacggc ttcctggaca tctggaccta caacgccgag     1320

ctgctggtgc tgctggagaa cgagagaacc ctggacttcc acgactccaa cgtgaagaac     1380

ttatacgaga aggtgaagag ccagctgaag aacaacgcca aagaaatcgg aaacggctgc     1440

ttcgaattct accacaagtg caacgacgaa tgcatggaga gcgtgaagaa cggaacctac     1500

gactacccca agtacagcga ggaaagcaaa ctgaacagag agaagatcga cggcgtgaag     1560

ttagagagca tgggcgtgta tcagatcctg gccatttata gcacggtggc cagcagcctg     1620

gtgctgctgg tgagcctggg cgccatcagc ttctggatgt gcagcaacgg cagcctgcag     1680

tgcagaatct gcatc                                                      1695


<210>  31
<211>  1584
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  MRK_sH1_Con

<400>  31
atgaaggtga agctgctggt gctgctgtgt accttcactg ccacttacgc cgacaccatt       60

tgcatcggct accacgccaa caacagcacc gataccgtgg acaccgtgct ggagaagaac      120

gtcaccgtga cccacagcgt gaacctgctg gaggatagcc ataacggcaa gctgtgcctg      180

ctgaagggaa tcgcccccct gcagctcggc aactgcagcg tggccggctg gattctgggc      240

aaccccgagt gcgaactgct gattagcaaa gagtcctgga gctacatcgt ggaaaccccg      300

aatcccgaga acggcacctg ctaccccggc tacttcgccg actacgaaga gctaagagag      360

cagctgagta gcgtgagctc attcgagaga ttcgagatct ttcccaagga gtctagctgg      420

cccaatcaca ccgtgaccgg cgtgagcgcc agctgtagcc acaacggcaa gagcagcttc      480

tacagaaacc tgctgtggct gaccggcaag aacggactgt accctaacct gagcaagagc      540

tacgcgaaca ataaggagaa ggaggtgcta gtgctgtggg gcgtgcacca cccccccaac      600

atcggcgacc agagagccct gtaccacacc gagaacgcct acgtgagcgt ggtgagcagc      660

cactatagca gaagattcac ccccgagatc gccaagagac caaaggtgag agatcaggaa      720

ggaagaataa actactactg gaccctcctg gagcccggcg acaccatcat cttcgaggct      780

aacggcaacc tgatcgcccc cagatacgcc ttcgccctga gcagaggctt cggcagcggc      840

atcatcacca gcaatgcccc catggatgag tgcgacgcca agtgccagac cccccagggc      900

gccatcaact cgagcctgcc cttccagaat gtgcaccccg tgaccatcgg cgagtgcccc      960

aagtacgtga gaagcgccaa gctgagaatg gtgaccggcc tgagaaacat cccaagcatc     1020

cagagcagag ggctgttcgg cgccatcgct ggcttcatcg agggcggctg gaccggcatg     1080

gtggacggct ggtacggtta tcaccaccag aacgagcagg gcagcggcta cgccgccgac     1140

cagaagagca cccagaacgc catcaacggc attacaaaca aggtgaacag cgttatcgag     1200

aagatgaaca cccaattcac cgccgtgggc aaggagttca acaagctgga gagaagaatg     1260

gagaacctga acaagaaggt ggacgacggc ttcctggaca tctggaccta caacgccgag     1320

ctgctggtgc tgctggagaa cgagagaacc ctggacttcc acgactccaa cgtgaagaac     1380

ttatacgaga aggtgaagag ccagctgaag aacaacgcca aagaaatcgg aaacggctgc     1440

ttcgaattct accacaagtg caacgacgaa tgcatggaga gcgtgaagaa cggaacctac     1500

gactacccca agtacagcga ggaaagcaaa ctgaacagag agaagatcga cggcgtgaag     1560

ttagagagca tgggcgtgta tcag                                            1584


<210>  32
<211>  1698
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Cobra_P1

<400>  32
atgaaggccc gcctcttggt gctgctgtgc gccctggcgg ccacagacgc cgacacaatc       60

tgtatcggct accacgccaa taatagcacc gataccgtgg ataccgtgct cgagaagaac      120

gtcaccgtta cacactccgt gaatttactg gaggacagcc acaatggcaa gctctgcaaa      180

ctgaagggta tcgccccact ccaactgggc aagtgcaaca tcgcaggctg gctgctgggc      240

aaccctgagt gtgagagcct gctgagcgct agaagctgga gctacatagt ggagacacct      300

aacagcgaaa acggcacatg ctaccccggc gacttcatcg attacgagga actgcgggag      360

cagctgagta gcgtgagctc ctttgagaga tttgagatct tccccaaaga gagcagctgg      420

cccaaccata ataccaccaa aggcgtgacc gccgcttgca gtcatgcagg gaaaagtagc      480

ttctaccgga acctgctctg gttgaccaag aagggaggga gctacccaaa gttgagcaaa      540

agctacgtga ataacaaggg caaggaggtg ctcgtgctgt ggggagtcca ccatcccagc      600

acatccactg atcagcagtc cctgtatcag aacgaaaacg cctacgtgag tgtggtgagc      660

tctaactaca acagacggtt cacccctgaa attgctgaga ggccaaaggt gagaggccag      720

gccggcagaa tgaactacta ttggaccctc ctggagcctg gggacacgat catcttcgag      780

gcgaccggga acctcatcgc tccctggtat gccttcgccc tgagcagggg cagtggcagc      840

ggaatcatca ccagcaacgc cagcatgcat gagtgcaaca ctaaatgcca gaccccccag      900

ggggccatca acagctccct gcccttccag aacatccatc ctgtgaccat tggggagtgc      960

cccaagtacg tgaggtccac caagctgagg atggtgactg gactgaggaa catccccagc     1020

atccagagcc gggggctgtt tggcgccatt gccggcttta tcgagggtgg ctggacaggt     1080

atgattgatg gctggtacgg ataccaccac cagaacgagc aggggagtgg gtatgctgcc     1140

gaccagaaat ctactcagaa cgccatcaat ggcatcacca ataaggtgaa cagcgtcatc     1200

gagaagatga acacccagtt caccgctgtg ggcaaggagt tcaacaacct ggaaaagcgc     1260

atggagaacc tgaacaagaa ggtggacgac ggcttcctgg acatctggac ctacaacgcc     1320

gagctgcttg tcctcctgga gaacgagagg accttggact tccatgacag caatgtgaag     1380

aacctctacg agaaagtgaa gagccagctg agaaacaatg ctaaggagat cggcaacggc     1440

tgcttcgagt tttaccacaa gtgcgacaat gagtgcatgg agagcgtgaa gaatggcact     1500

tatgactacc ccaagtactc agaggagtcc aaactgaata gagagaagat tgatggcgtc     1560

aagctagagt ccatgggcgt ttaccagatc ctggcaatct atagcaccgt ggccagctcc     1620

ctggtgctgc tggtgtcact gggagccata tccttctgga tgtgctccaa cggcagcctt     1680

cagtgtagaa tctgcatc                                                   1698


<210>  33
<211>  1698
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Cobra_X3

<400>  33
atggaggccc gcctgctcgt gcttctgtgc gcctttgccg ccactaacgc cgacaccatc       60

tgtatcggct accacgccaa caatagtaca gataccgtgg acactgtgct ggagaagaac      120

gtaacagtga cacattctgt caacctgctc gaggactctc ataatggcaa gctgtgccgc      180

ctgaagggca tcgcccctct gcagctggga aattgctccg tggccggctg gatcctgggc      240

aatccggaat gcgaaagcct gttcagcaag gagagctgga gctacatcgc cgagacacct      300

aaccctgaga acgggacctg ctaccctgga tacttcgccg actacgaaga gctgcgggag      360

cagctcagct cagtgtcatc cttcgagcgg ttcgagatct tccccaagga gagctcttgg      420

cccaaccaca ccgtgaccaa gggcgtcaca gcaagctgta gccacaacgg caagagctcc      480

ttctatagaa acctgctgtg gctgaccgag aagaacggcc tgtaccccaa tctgagtaag      540

tcctacgtga acaacaagga aaaggaagtg ctggtgctgt ggggcgtgca ccacccctcc      600

aacatcggcg accagcgcgc catctaccac actgagaatg catacgtaag cgttgtcagc      660

tcccactata gtaggagatt cacacccgag atcgctaaga ggcccaaggt gagagaccag      720

gagggcagaa tcaattatta ctggaccctg ctggagcccg gagacaccat tatcttcgaa      780

gctaacggca atttgatcgc cccttggtat gcctttgccc tctcaagggg tttcgggagc      840

ggaattatca cctccaatgc cagcatggat gagtgcgacg ccaagtgcca gacgcctcag      900

ggcgccatta attcctccct gcccttccag aacgtgcacc ccgtgaccat cggggagtgc      960

cccaagtatg ttagatccac taagctcagg atggtgacag gactgcgcaa catcccgagc     1020

attcagagca ggggcctctt cggggccatt gctgggttca tcgagggcgg gtggaccggc     1080

atgatcgacg gctggtatgg ctaccaccac cagaacgagc agggcagcgg gtacgctgct     1140

gaccaaaagt ccacccaaaa tgctatcaac ggcatcacca acaaggttaa tagcgtcatc     1200

gaaaagatga atacccagtt cacagccgtg ggaaaggaat tcaacaagct ggaacgacgg     1260

atggagaacc tgaataagaa ggtggacgac gggttcctgg acatctggac ttataacgct     1320

gagctgctcg tgctgttaga gaacgagaga accctggact ttcacgacag caacgtgaag     1380

aacctgtacg agaaggtgaa gtctcagctg aaaaataacg ctaaggaaat tggcaacggg     1440

tgcttcgaat tctatcacaa gtgcaacaac gaatgcatgg agagtgttaa gaacggaacc     1500

tatgactacc ccaagtacag tgaggaaagt aaactgaata gggagaagat cgacggcgtg     1560

aaactggagt ccatgggggt ttaccagatt ctggccatct atagcaccgt ggccagcagc     1620

ttagtgctgc tggtgtccct cggcgctatt agcttctgga tgtgcagcaa cggaagcctg     1680

cagtgtcgga tatgcatc                                                   1698


<210>  34
<211>  2052
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ConH1_ferritin

<400>  34
atgaaggcga agctccttgt gctgctctgc gcgttcaccg ccaccgacgc agatacaatt       60

tgcatcggat accacgccaa caattccacc gacaccgtgg acaccgttct ggagaaaaac      120

gtgacggtga cccacagcgt gaacctcctg gaggatagcc ataacggcaa gctgtgtaag      180

ctgaaaggca tcgcccccct gcagctggga aagtgcaaca ttgctggatg gatcctggga      240

aatcccgagt gtgaaagcct cattagcaaa cgcagctgga gctacattgt ggagacccca      300

aattctgaga atgggacctg ttaccctggc gactttgccg actacgagga gctgagagag      360

cagttgagca gcgtcagctc cttcgagaga ttcgaaatct ttccaaagga gtcttcgtgg      420

cccaaccaca acgtgactaa gggcgtcacc gcagcttgta gccacgcggg caaatcttcc      480

ttctacagaa acctactgtg gctcaccgag aaaaacggca gctaccccaa gctgagcaag      540

agctacgtga ataacaaaga gaaggaagtg ctggtgctgt ggggcgtcca ccaccccagc      600

aacatcacag accaaagaac actctaccag aacgagaacg cctacgtgag tgtggtgtcc      660

agccattaca accgccgatt cacccccgag atcgccaaac ggcccaaagt gcggggccag      720

gccggaagaa ttaactacta ctggaccctc ctggaaccag gagacaccat tatcttcgaa      780

gccaatggca atctgatcgc tccctggtac gccttcgcac tgtcgagagg gtttggcagc      840

ggcatcatca cctccaacgc cccaatgcat gaatgtgata ccaagtgcca gaccccacag      900

ggcgccatta acagcagcct gccattccag aacgtccatc ccgtgacaat cggcgagtgt      960

cctaagtacg tgcgctcaac gaaactgagg atggtgacag gactgagaaa cattccctca     1020

atccagagca gagggctgtt cggcgccata gccggattca ttgagggcgg atggacaggc     1080

atgattgacg gctggtatgg ctaccaccat cagaacgagc aaggcagtgg ctacgcagcc     1140

gaccagaaga gcacacagaa cgccattaac gggatcacca acaaggtgaa tagcgtgatc     1200

gagaagatga atacccagtt cactgccgtg ggtaaggagt tcaacaagct ggagaagcgg     1260

atggagaacc tcaacaagaa agtcgatgat ggcttcctgg acatctggac ctataatgct     1320

gaactgctcg tgctacttga gaatgagagg acgcttgact ttcacgactc caacgtaaaa     1380

aacctgtacg agaaggtgaa gtcgcagctg aaaaataacg ccaaggaaat cggcaacggc     1440

tgttttgagt tttaccataa atgcaataac gagtgcatgg agagcgtgaa gaatggcacc     1500

tacgactatc ccaaatactc cgaggagagc aagctcaacc gggagaaaat cgatagcggc     1560

ggggatatca ttaagctgct taacgagcag gtcaacaagg agatgcagtc aagcaacctt     1620

tacatgagca tgagcagctg gtgttacaca cacagcctgg acggagccgg actgttcctg     1680

ttcgaccacg ctgcagagga atatgagcac gctaagaagc ttataatttt cctcaacgag     1740

aataacgtgc ccgtccagct gacctccatc agcgcccccg agcacaagtt tgagggcctg     1800

acccagatct tccagaaggc ctacgagcac gagcagcaca tcagcgagtc tatcaacaac     1860

atcgtagacc atgcaatcaa gtctaaggac cacgctacat ttaactttct gcaatggtac     1920

gtggctgaac aacacgagga ggaggtactg ttcaaggata ttctcgacaa gatcgaactc     1980

atcgggaatg agaaccacgg cctgtacctg gccgaccagt acgtgaaagg aattgccaaa     2040

tccagaaagt cc                                                         2052


<210>  35
<211>  2055
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ConH3_ferritin

<400>  35
atgaagacaa tcattgccct gagctacatt ttttgcttag tgtttgctca gaaactgcca       60

ggcaacgata attcaacagc caccttgtgc ctcggccacc acgctgtgcc taacggcact      120

ctggtgaaga ccatcaccaa cgaccagatc gaggtgacca acgccacgga gctggtgcag      180

tcaagctcca ccggaagaat ctgcgatagc ccccatagga ttctggatgg caccaactgc      240

accctgattg acgccctgct cggcgatccc cactgcgacg gtttccaaaa caaggagtgg      300

gacctgtttg tggagagaag caaggcctat tcaaattgct acccttacga cgtccctgat      360

tacgcctcac tcaggtccct ggtggccagc agcgggaccc tggaattcaa caatgagggg      420

ttcaactgga ccggggtgac ccaaaacggc ggctccagcg cctgtaagag gggcagcgac      480

aagtccttct tctctaggct gaactggttg cacaaactga agtacaagta ccctgcatta      540

aacgtgacca tgcccaacaa cgataaattc gacaagctgt acatctgggg agtgcatcac      600

cccagcacag actcagacca gaccagtctg tatgtgcagg caagcgggag ggtgacggtc      660

tccaccaagc ggagccagca gaccgtgatc cccaacatcg gctccagacc atgggtcagg      720

ggcctgagca gccggatctc catctactgg accatagtga agcctggcga catcctgctg      780

atcaacagca ccggcaacct catcgcccct cgcggttact tcaagatccg tagtggcaaa      840

tcaagcatca tgagatccga cgcacccatc gggacctgca atagcgagtg catcaccccc      900

aacggatcta tccctaatga caagcctttt cagaacgtga accggattac ctatggtgcc      960

tgccccagat acgtgaagca gaacaccctg aagctggcga ccggcatgcg caacgtgccg     1020

gaaaagcaga cccggggcat cttcggcgcc attgccgggt ttattgagaa tggctgggaa     1080

ggcatggtgg atgggtggta cggctttagg catcagaact ctgagggtac tggtcaggcc     1140

gccgacctga aatccaccca ggccgccatt gaccagatta acgggaaact taacagactg     1200

attgagaaga ccaatgagaa gttccaccag atcgaaaagg aattctccga agtggagggc     1260

aggattcagg acttagagaa atatgtggag gataccaaga tcgacctgtg gagctataac     1320

gccgagctgc ttgtggctct ggagaaccag cacaccatcg atctgaccga cagcgagatg     1380

aataagctgt tcgagaggac acgcaagcag ctgagggaga acgccgagga catggggaac     1440

gggtgcttta agatctatca caagtgcgac aatgcctgca tcgggtctat cagaaatggc     1500

acttatgatc atgacgtgta cagagatgag gccctgaata atagatttca aattaagtcc     1560

gggggtgaca tcattaaact gctgaacgaa caagtgaata aagagatgca gagctctaac     1620

ttgtacatga gcatgagcag ttggtgctac acacactctc tggacggggc tggcctgttc     1680

ctgttcgatc acgcagcaga ggagtatgag cacgccaaaa aactgattat cttcctcaac     1740

gagaacaacg tgcccgtcca gctcacctcc atctcagccc ccgagcacaa gttcgagggc     1800

ctcacccaga tcttccagaa agcatatgag catgaacagc atatcagtga aagcatcaac     1860

aatatcgtgg accacgctat taaatcaaag gatcacgcca ccttcaactt tctgcagtgg     1920

tatgtcgccg agcagcatga ggaggaggtg ctttttaaag acatcctgga caagatcgag     1980

ctgatcggca acgaaaacca tggcctgtac ctggctgacc agtatgtgaa gggaattgcc     2040

aagtccagaa aatcc                                                      2055


<210>  36
<211>  2052
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  MRK_pH1_Con_ferritin

<400>  36
atgaaggcga ttctggttgt gctgctgtac accttcgcca ccgccaacgc cgacacactg       60

tgcattggct accacgccaa taacagcacg gacaccgtgg acacggtgct ggagaaaaac      120

gtgaccgtga cccacagcgt gaacctgctg gaggacaagc acaacggtaa gttgtgcaag      180

ctcaggggag tggcaccact gcacttgggc aagtgtaata tcgctggctg gatattggga      240

aatccagagt gcgaaagcct gagtactgcc tccagctgga gctacattgt ggagaccagc      300

agcagcgaca acggcacctg ctaccccggc gacttcatcg actatgagga attgagggaa      360

cagctgagtt cagtttccag cttcgagcga tttgagatat ttcccaagac gtcctcttgg      420

cccaaccacg acagcaacaa gggcgtgaca gccgcctgcc cccacgccgg ggcgaagagc      480

ttctacaaga acctgatctg gctggtgaag aagggcaaca gctacccaaa gctatccaag      540

tcctatatta acgacaaagg caaggaggtg ttggtgctct ggggcattca ccacccctcc      600

acctccgccg accagcaaag tctttaccag aacgcggacg cctacgtctt tgtcggcacc      660

agcagataca gcaagaagtt taagcccgag attgctatca gacccaaggt gagagaccag      720

gaaggcagaa tgaactatta ttggaccctg gtggaacccg gcgacaaaat aacattcgaa      780

gccaccggga atctggtggt gcccagatat gcctttgcca tggagcgcaa tgccggcagc      840

ggcattatta tctctgacac ccccgtgcac gactgcaaca ccacctgtca gacccctaag      900

ggggctatca acaccagcct gcccttccag aatattcacc ccatcactat cggcaagtgc      960

cccaagtacg tcaagagcac aaaactgaga ctggccacag ggctgaggaa tgtacctagc     1020

atccagtcca gagggctgtt cggggccatc gctggcttca tcgaaggagg ctggaccggc     1080

atggtcgatg gatggtacgg atatcaccac caaaacgagc aggggtcagg atacgccgct     1140

gacctgaaga gcacccagaa cgccatcgac aagatcacca acaaggtgaa tagcgtgatc     1200

gagaagatga acacccagtt caccgcagtg ggcaaggagt tcaaccacct ggagaagaga     1260

atcgagaacc tgaacaagaa agtggatgac gggttcctgg acatctggac ctacaacgcc     1320

gagcttctgg tgctcttgga gaatgagaga accctggatt atcatgacag caatgtcaaa     1380

aacctctacg agaaggtgcg gagccagctg aagaacaacg caaaggagat tggcaacggc     1440

tgcttcgagt tttatcacaa gtgcgacaac acttgtatgg agagcgttaa gaatggcact     1500

tacgattacc ccaagtactc cgaggaagcc aagctgaaca gagaagaaat cgactccggc     1560

ggcgacataa tcaagctcct gaacgaacag gtgaacaagg agatgcaaag ctccaacctc     1620

tacatgagca tgagctcatg gtgctacact cacagcctgg acggagctgg actgttcttg     1680

ttcgaccacg cggccgagga gtacgagcac gccaagaagc tcatcatctt ccttaacgag     1740

aataacgtgc cagtgcagct cacctccatc agcgcccccg agcataagtt cgagggtctg     1800

acccaaatct tccagaaggc ttacgagcat gagcagcaca tcagcgagag cattaacaac     1860

atcgtggatc acgctattaa atctaaagac cacgccacct tcaacttcct gcagtggtac     1920

gtggcagaac agcacgagga ggaggtcctg ttcaaggata tactggacaa aatcgagctg     1980

atcggcaacg agaaccacgg cctgtacctg gccgatcagt acgtcaaagg tattgccaag     2040

tctcgcaaga gc                                                         2052


<210>  37
<211>  2049
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  MRK_sH1_Con_ferritin

<400>  37
atgaaggtga agctgcttgt gctgctgtgc accttcaccg ctacctacgc agacacaatc       60

tgtatcggat accacgccaa taactcaacc gatacagtgg acaccgtgct cgagaagaac      120

gtgacagtga cgcacagcgt gaacctgctt gaggattccc ataacggtaa gctctgtctg      180

ctgaagggca tcgcccctct tcagctggga aactgctccg ttgccggctg gatcctgggc      240

aaccccgagt gtgagcttct gatcagcaag gagtcgtggt catatatcgt ggagacccct      300

aatccagaga acggaacctg ttaccccggc tactttgccg actacgagga gctcagagag      360

cagctgagca gcgtgagcag cttcgagaga ttcgagatct tccccaagga gagcagttgg      420

cctaatcaca ccgtgaccgg cgtgagcgcc tcctgcagcc acaacggcaa gtcttccttt      480

tacagaaacc tgctgtggct gacaggcaaa aacgggttgt accctaacct gagcaagtcc      540

tatgctaaca ataaggagaa ggaagtcctg gtgttgtggg gcgttcacca tcccccaaac      600

atcggagacc aacgcgccct atatcacact gagaacgcct acgtgagcgt ggtgtcaagc      660

cactatagca gacggttcac ccccgaaatc gcaaagagac cgaaggtgcg ggaccaggag      720

ggaaggatta actattactg gacactcctg gagcccgggg acactatcat ctttgaagcc      780

aacgggaacc tcatcgcacc caggtacgct ttcgctctgt ccaggggatt cgggagcggt      840

atcattacct cgaacgcccc gatggatgag tgcgacgcca aatgccaaac cccccagggc      900

gctattaact ctagcctccc ttttcagaac gtgcaccccg tgaccatcgg agagtgcccc      960

aagtacgtgc ggagcgctaa gctcaggatg gtgaccggcc tgcggaacat cccctctatc     1020

caatccaggg gtctgttcgg cgccattgcc ggatttatcg agggcgggtg gaccgggatg     1080

gtggatggat ggtatggata ccaccatcag aatgaacaag gcagcggata cgccgccgat     1140

cagaagtcaa cacaaaacgc catcaacgga attaccaaca aagtcaactc cgtgatcgag     1200

aagatgaaca cccagttcac ggccgtgggc aaagagttca acaagctcga gcggcgaatg     1260

gagaacctca acaagaaggt ggacgatgga ttcctggaca tctggacgta caatgccgaa     1320

ctgctcgtgc tgctggaaaa cgagagaaca ctcgatttcc acgacagcaa cgtgaagaat     1380

ctgtatgaga aggtcaaatc ccagttgaag aacaacgcca aggagatcgg caatggctgt     1440

ttcgagttct atcacaagtg taatgacgag tgcatggaga gcgttaagaa cggcacctac     1500

gactacccca aatacagcga agagagcaag ctgaaccgtg agaagatcga cagcggaggc     1560

gatatcatca agctgctgaa cgaacaggtg aacaaggaga tgcagtccag caatctctac     1620

atgagtatgt cctcgtggtg ctacacccac agcctggatg gagccggact gtttctgttc     1680

gaccacgccg ccgaggagta cgagcatgcc aaaaagctga tcatcttcct caatgaaaac     1740

aacgtgcccg tgcagttgac cagcatcagc gcccccgagc ataaattcga gggactgaca     1800

cagatctttc agaaggccta tgagcacgag cagcacatca gcgaaagcat caacaacatc     1860

gtggaccacg ccatcaagtc caaggatcac gccaccttca acttcctgca gtggtacgtt     1920

gccgaacagc acgaggagga ggtgctgttt aaggacatcc tggacaaaat cgaactgatc     1980

ggaaacgaga accatggtct gtacctcgcc gaccagtacg tgaagggaat cgccaagagc     2040

aggaagtcg                                                             2049


<210>  38
<211>  2052
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Cobra_P1_ferritin

<400>  38
atgaaggcca gactgttggt gctgctgtgt gcccttgccg ccacagacgc cgacaccatc       60

tgtatcggct accacgctaa taacagcacc gacaccgtgg acacagtgct tgaaaagaac      120

gtgacagtga cccacagcgt taacctgctt gaggactctc acaacgggaa gctgtgtaaa      180

ctgaagggga tcgcccctct gcagctgggc aagtgcaaca tcgctggctg gctgctggga      240

aatcccgagt gtgagagcct gctgtccgct cgtagctgga gctacatagt tgaaacccct      300

aacagcgaga atggcacctg ctaccctgga gacttcatcg actacgagga gctcagagag      360

cagctgagca gcgtgagctc gtttgaaaga tttgagatct ttcccaagga gtcctcatgg      420

cccaaccaca acactaccaa aggcgtgacc gctgcttgtt cacacgctgg caaatcctcc      480

ttctaccgga acctgctgtg gctgaccaag aaaggcggat cctaccccaa actgagcaag      540

tcatacgtga ataacaaggg caaagaggtg ctggtgctgt ggggcgtgca ccacccctcc      600

accagcaccg atcagcaaag cctgtaccag aacgagaacg cctacgtcag cgttgtgagc      660

agcaactaca accggagatt cacccccgag attgccgaga gacctaaggt gagagggcag      720

gctggcagaa tgaactacta ttggactctg ctggagcccg gagacacaat tatcttcgag      780

gccactggca atctgatcgc accctggtac gccttcgcct taagcagggg cagcgggtct      840

ggaattatca cttccaatgc cagcatgcac gagtgcaaca ccaagtgcca gaccccccag      900

ggcgccatta acagcagcct gcccttccag aacatccacc ccgtcactat cggcgagtgc      960

cccaagtatg tgaggagcac taagctgagg atggtgaccg ggcttagaaa catccccagc     1020

atccagtcaa gaggcctatt cggcgcaata gccggcttca ttgaaggcgg ctggaccggg     1080

atgatcgatg gctggtatgg ctatcaccat cagaacgagc aaggctccgg gtacgccgcc     1140

gaccagaaat ccacacagaa tgccatcaat ggaattacta acaaggttaa ttccgtcatc     1200

gagaagatga atacccagtt taccgccgtg ggaaaggagt tcaacaatct ggagaagcgg     1260

atggagaacc tcaacaagaa ggtagatgat ggattcctcg acatctggac atacaatgct     1320

gaactgctgg tgctgctcga gaacgagaga accttagact tccacgacag caacgtgaag     1380

aatctgtacg agaaggttaa gtctcaactg agaaataacg ctaaggagat tggcaatggc     1440

tgtttcgagt tctaccacaa gtgtgacaac gaatgtatgg aatctgtgaa gaacgggacc     1500

tacgactacc ccaagtacag cgaggagagc aagctgaaca gagagaagat cgactcaggc     1560

ggcgacatca ttaagctgct gaatgagcag gttaataagg agatgcagag ctccaatctg     1620

tatatgagta tgagcagctg gtgttacact cactccctgg acggcgccgg actgttcctg     1680

ttcgaccacg ctgcagagga gtacgaacac gcaaaaaagc tgataatctt tctgaatgaa     1740

aacaacgtgc ccgtccagct gacctctatt tctgccccag agcacaagtt cgagggcctg     1800

acacagatct tccaaaaggc ctacgaacac gagcagcaca tcagcgagtc aatcaacaac     1860

atagtcgatc acgccattaa gtctaaggac cacgccacct tcaacttcct ccagtggtat     1920

gtggccgagc agcacgagga ggaggttctt tttaaggata ttctcgataa aatcgagttg     1980

atcggcaacg agaatcatgg cctgtacctg gcagaccaat atgtgaaggg gatcgccaag     2040

tcaaggaaga gc                                                         2052


<210>  39
<211>  2052
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Cobra_X3_ferritin

<400>  39
atggaggcca gactgctggt gctgctgtgc gccttcgccg ccaccaacgc agacaccatc       60

tgcattggct accacgccaa caacagcacc gataccgtgg acacagtgct cgaaaagaac      120

gtgacagtga ctcacagcgt gaacctcctg gaggacagcc acaacggcaa gctgtgccgg      180

ctgaagggta tcgccccctt gcagctggga aactgcagcg tggcagggtg gatcttgggc      240

aatcccgagt gcgaaagtct gttttctaag gagtcctggt cctacatcgc cgagacaccg      300

aaccccgaaa acggaacatg ctatcctggc tacttcgctg actacgaaga gctgcgggag      360

cagcttagct ccgtctccag ctttgagcgg tttgagatct tcccgaaaga gtctagctgg      420

cccaatcaca cagtcaccaa gggggtgacc gcatcctgca gccacaacgg caagtcctct      480

ttctacagaa acctgctgtg gctgaccgag aaaaacgggc tgtaccctaa cctttccaag      540

agctatgtca acaacaagga gaaggaggtg ctggtgctgt ggggggttca ccaccccagc      600

aacatcggag accagagagc tatctatcac accgaaaacg cctacgtgag cgtggtgagc      660

agccattata gcagacgctt cacccctgag attgccaaac ggcccaaagt gcgggaccag      720

gagggcagaa tcaactatta ctggaccctc ctggaacctg gcgataccat tatctttgag      780

gccaacggca acctgatcgc cccatggtac gcctttgctc tgagccgggg ctttggctca      840

ggcatcatta ccagcaacgc cagcatggac gagtgcgatg ccaagtgcca gacaccccag      900

ggcgccatca acagctccct gccctttcaa aatgtccatc ccgtgaccat cggcgagtgt      960

cccaagtacg tccggtccac taaactgcgg atggtgaccg gactcagaaa tatcccaagc     1020

atccagagca gaggcctgtt tggcgccatc gctggattta tcgagggagg ctggactggc     1080

atgatcgatg gctggtacgg ctatcatcat cagaacgagc agggcagcgg atatgccgca     1140

gaccagaagt cgacccagaa cgccatcaat ggaattacca acaaggtgaa cagcgtgatc     1200

gagaagatga acacccagtt cactgccgtc ggcaaggaat tcaacaagct ggaacgtcgg     1260

atggaaaacc tcaacaaaaa ggtggatgac ggcttcctgg atatctggac ctacaacgcc     1320

gagctcctgg tgctccttga gaacgagaga accctcgatt tccacgatag caacgtgaaa     1380

aatctctacg aaaaggtgaa gagccagctg aaaaataacg ccaaggagat agggaatggc     1440

tgcttcgagt tctaccataa gtgcaacaac gagtgcatgg agagcgtcaa aaacggcact     1500

tacgattacc ccaagtattc agaagagagc aaactgaaca gggaaaaaat tgactccggc     1560

ggagacatta tcaagctgct gaatgaacag gtgaacaaag agatgcagag ctccaacctt     1620

tacatgagca tgagcagctg gtgctatacc cattccctcg acggggccgg gctgttcctg     1680

ttcgaccatg ccgctgaaga atacgagcac gccaagaaac tgatcatctt cttaaacgag     1740

aacaatgtgc cagtgcagct gacctcaatc agcgcccccg agcacaagtt cgagggactc     1800

actcagattt tccagaaggc ctacgagcac gagcaacaca ttagcgaatc catcaacaat     1860

atcgtggacc acgccataaa gagcaaggac catgccacct ttaacttcct tcaatggtac     1920

gtggccgagc agcacgagga ggaggtcctg ttcaaggaca tcctcgacaa aatcgagctg     1980

atcggcaatg aaaaccatgg cctctacctg gctgaccagt atgtgaaagg tatcgctaag     2040

tcaagaaaaa gc                                                         2052


<210>  40
<211>  1494
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Wildtype Sequence of Nucleoprotein

<400>  40
atggccagcc agggcaccaa gagaagctac gagcagatgg agaccgacgg cgagagacag       60

aacgccaccg agatcagagc cagcgtgggc aagatgatcg acggcatcgg cagattctac      120

atccagatgt gcaccgagct caagctgagc gactacgagg gcagactgat ccagaacagc      180

ctgaccatcg aaagaatggt tctgagcgcc ttcgacgaga gaagaaacag atacctggag      240

gagcacccca gcgccggcaa ggaccccaag aagaccggcg gccccatcta caagagagtg      300

gacggcagat ggatgagaga gctggtgctg tacgacaagg aggagatcag aagaatctgg      360

agacaggcca acaacggcga cgacgccacc gccggcctga cccacatgat gatctggcac      420

agcaacctga acgacaccac ctaccagaga accagagccc tggtgagaac cggcatggac      480

cccagaatgt gcagcttaat gcagggcagc accctgccca gaagatccgg cgccgctggt      540

gccgccgtca agggcatcgg caccatggtg atggagctga tccgcatgat caagcgcggc      600

atcaacgaca gaaacttctg gagaggcgaa aacggcagaa agaccagaag cgcctacgag      660

agaatgtgca acatcctgaa gggcaagttc cagaccgccg cccaaagagc catgatggac      720

caggtgagag agagcagaaa ccccggcaac gccgagatcg aagacctgat cttcagcgcc      780

agatcggccc tgatcctgag aggcagcgtg gcccacaaga gctgcctgcc cgcctgcgtg      840

tatggccccg ccgtgagcag cggctacaac ttcgagaagg agggctacag cctggtgggc      900

atcgacccct tcaagctgct gcagaactct caggtgtata gcctgatcag acccaacgag      960

aaccccgccc acaagagcca gctggtgtgg atggcctgcc acagcgccgc cttcgaggac     1020

ctgagactgc tgagcttcat cagaggtacc aaggtgtccc ccagaggcaa gctgagcacc     1080

agaggtgtgc agatcgccag caatgagaac atggacaata tggagagcag caccctggag     1140

ctaagaagca ggtactgggc catccggacc agaagcggcg gcaataccaa ccagcagaga     1200

gccagcgccg gccagatcag cgtgcagccc accttcagcg tgcagagaaa cctgcccttt     1260

gagaagagca ccgtgatggc cgccttcacc ggcaacaccg agggcagaac cagcgacatg     1320

agagccgaga tcatcagaat gatggagggc gccaagcccg aggaggtgag ctttagaggc     1380

agaggcgtgt tcgagctgag cgacgagaag gccaccaacc caattgtgcc cagcttcgac     1440

atgtcgaacg agggcagcta cttcttcggc gacaacgccg aggagtacga caac           1494


<210>  41
<211>  566
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MRK_H3_consUnique

<400>  41

Met Lys Thr Ile Ile Ala Leu Ser Tyr Ile Leu Cys Leu Val Phe Ala 
1               5                   10                  15      


Gln Lys Leu Pro Gly Asn Asp Asn Ser Thr Ala Thr Leu Cys Leu Gly 
            20                  25                  30          


His His Ala Val Pro Asn Gly Thr Ile Val Lys Thr Ile Thr Asn Asp 
        35                  40                  45              


Gln Ile Glu Val Thr Asn Ala Thr Glu Leu Val Gln Ser Ser Ser Thr 
    50                  55                  60                  


Gly Glu Ile Cys Asp Ser Pro His Gln Ile Leu Asp Gly Glu Asn Cys 
65                  70                  75                  80  


Thr Leu Ile Asp Ala Leu Leu Gly Asp Pro Gln Cys Asp Gly Phe Gln 
                85                  90                  95      


Asn Lys Lys Trp Asp Leu Phe Val Glu Arg Ser Lys Ala Tyr Ser Asn 
            100                 105                 110         


Cys Tyr Pro Tyr Asp Val Pro Asp Tyr Ala Ser Leu Arg Ser Leu Val 
        115                 120                 125             


Ala Ser Ser Gly Thr Leu Glu Phe Asn Asn Glu Ser Phe Asn Trp Thr 
    130                 135                 140                 


Gly Val Thr Gln Asn Gly Thr Ser Ser Ala Cys Ile Arg Arg Ser Asn 
145                 150                 155                 160 


Ser Ser Phe Phe Ser Arg Leu Asn Trp Leu Thr His Leu Asn Phe Lys 
                165                 170                 175     


Tyr Pro Ala Leu Asn Val Thr Met Pro Asn Asn Glu Gln Phe Asp Lys 
            180                 185                 190         


Leu Tyr Ile Trp Gly Val His His Pro Gly Thr Asp Lys Asp Gln Ile 
        195                 200                 205             


Phe Leu Tyr Ala Gln Ala Ser Gly Arg Ile Thr Val Ser Thr Lys Arg 
    210                 215                 220                 


Ser Gln Gln Ala Val Ile Pro Asn Ile Gly Ser Arg Pro Arg Val Arg 
225                 230                 235                 240 


Asn Ile Pro Ser Arg Ile Ser Ile Tyr Trp Thr Ile Val Lys Pro Gly 
                245                 250                 255     


Asp Ile Leu Leu Ile Asn Ser Thr Gly Asn Leu Ile Ala Pro Arg Gly 
            260                 265                 270         


Tyr Phe Lys Ile Arg Ser Gly Lys Ser Ser Ile Met Arg Ser Asp Ala 
        275                 280                 285             


Pro Ile Gly Lys Cys Asn Ser Glu Cys Ile Thr Pro Asn Gly Ser Ile 
    290                 295                 300                 


Pro Asn Asp Lys Pro Phe Gln Asn Val Asn Arg Ile Thr Tyr Gly Ala 
305                 310                 315                 320 


Cys Pro Arg Tyr Val Lys Gln Asn Thr Leu Lys Leu Ala Thr Gly Met 
                325                 330                 335     


Arg Asn Val Pro Glu Lys Gln Thr Arg Gly Ile Phe Gly Ala Ile Ala 
            340                 345                 350         


Gly Phe Ile Glu Asn Gly Trp Glu Gly Met Val Asp Gly Trp Tyr Gly 
        355                 360                 365             


Phe Arg His Gln Asn Ser Glu Gly Arg Gly Gln Ala Ala Asp Leu Lys 
    370                 375                 380                 


Ser Thr Gln Ala Ala Ile Asp Gln Ile Asn Gly Lys Leu Asn Arg Leu 
385                 390                 395                 400 


Ile Gly Lys Thr Asn Glu Lys Phe His Gln Ile Glu Lys Glu Phe Ser 
                405                 410                 415     


Glu Val Glu Gly Arg Ile Gln Asp Leu Glu Lys Tyr Val Glu Asp Thr 
            420                 425                 430         


Lys Ile Asp Leu Trp Ser Tyr Asn Ala Glu Leu Leu Val Ala Leu Glu 
        435                 440                 445             


Asn Gln His Thr Ile Asp Leu Thr Asp Ser Glu Met Asn Lys Leu Phe 
    450                 455                 460                 


Glu Lys Thr Lys Lys Gln Leu Arg Glu Asn Ala Glu Asp Met Gly Asn 
465                 470                 475                 480 


Gly Cys Phe Lys Ile Tyr His Lys Cys Asp Asn Ala Cys Ile Gly Ser 
                485                 490                 495     


Ile Arg Asn Gly Thr Tyr Asp His Asp Val Tyr Arg Asp Glu Ala Leu 
            500                 505                 510         


Asn Asn Arg Phe Gln Ile Lys Gly Val Glu Leu Lys Ser Gly Tyr Lys 
        515                 520                 525             


Asp Trp Ile Leu Trp Ile Ser Phe Ala Ile Ser Cys Phe Leu Leu Cys 
    530                 535                 540                 


Val Ala Leu Leu Gly Phe Ile Met Trp Ala Cys Gln Lys Gly Asn Ile 
545                 550                 555                 560 


Arg Cys Asn Ile Cys Ile 
                565     


<210>  42
<211>  566
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MRK_H3_ConsensusA

<400>  42

Met Lys Thr Ile Ile Ala Leu Ser Tyr Ile Leu Cys Leu Val Phe Ala 
1               5                   10                  15      


Gln Lys Leu Pro Gly Asn Asp Asn Ser Thr Ala Thr Leu Cys Leu Gly 
            20                  25                  30          


His His Ala Val Pro Asn Gly Thr Leu Val Lys Thr Ile Thr Asn Asp 
        35                  40                  45              


Gln Ile Glu Val Thr Asn Ala Thr Glu Leu Val Gln Ser Ser Ser Thr 
    50                  55                  60                  


Gly Arg Ile Cys Asp Ser Pro His Arg Ile Leu Asp Gly Glu Asn Cys 
65                  70                  75                  80  


Thr Leu Ile Asp Ala Leu Leu Gly Asp Pro His Cys Asp Gly Phe Gln 
                85                  90                  95      


Asn Lys Glu Trp Asp Leu Phe Val Glu Arg Ser Lys Ala Tyr Ser Asn 
            100                 105                 110         


Cys Tyr Pro Tyr Asp Val Pro Asp Tyr Ala Ser Leu Arg Ser Leu Val 
        115                 120                 125             


Ala Ser Ser Gly Thr Leu Glu Phe Asn Asn Glu Ser Phe Asn Trp Thr 
    130                 135                 140                 


Gly Val Ala Gln Asn Gly Thr Ser Tyr Ala Cys Lys Arg Gly Ser Val 
145                 150                 155                 160 


Lys Ser Phe Phe Ser Arg Leu Asn Trp Leu His Gln Leu Lys Tyr Lys 
                165                 170                 175     


Tyr Pro Ala Leu Asn Val Thr Met Pro Asn Asn Asp Lys Phe Asp Lys 
            180                 185                 190         


Leu Tyr Ile Trp Gly Val His His Pro Ser Thr Asp Ser Asp Gln Thr 
        195                 200                 205             


Ser Leu Tyr Val Gln Ala Ser Gly Arg Val Thr Val Ser Thr Lys Arg 
    210                 215                 220                 


Ser Gln Gln Thr Val Ile Pro Asn Ile Gly Ser Arg Pro Trp Val Arg 
225                 230                 235                 240 


Gly Val Ser Ser Arg Ile Ser Ile Tyr Trp Thr Ile Val Lys Pro Gly 
                245                 250                 255     


Asp Ile Leu Leu Ile Asn Ser Thr Gly Asn Leu Ile Ala Pro Arg Gly 
            260                 265                 270         


Tyr Phe Lys Ile Arg Ser Gly Lys Ser Ser Ile Met Arg Ser Asp Ala 
        275                 280                 285             


Pro Ile Gly Lys Cys Asn Ser Glu Cys Ile Thr Pro Asn Gly Ser Ile 
    290                 295                 300                 


Pro Asn Asp Lys Pro Phe Gln Asn Val Asn Arg Ile Thr Tyr Gly Ala 
305                 310                 315                 320 


Cys Pro Arg Tyr Val Lys Gln Asn Thr Leu Lys Leu Ala Thr Gly Met 
                325                 330                 335     


Arg Asn Val Pro Glu Lys Gln Thr Arg Gly Ile Phe Gly Ala Ile Ala 
            340                 345                 350         


Gly Phe Ile Glu Asn Gly Trp Glu Gly Met Val Asp Gly Trp Tyr Gly 
        355                 360                 365             


Phe Arg His Gln Asn Ser Glu Gly Thr Gly Gln Ala Ala Asp Leu Lys 
    370                 375                 380                 


Ser Thr Gln Ala Ala Ile Asn Gln Ile Asn Gly Lys Leu Asn Arg Leu 
385                 390                 395                 400 


Ile Glu Lys Thr Asn Glu Lys Phe His Gln Ile Glu Lys Glu Phe Ser 
                405                 410                 415     


Glu Val Glu Gly Arg Ile Gln Asp Leu Glu Lys Tyr Val Glu Asp Thr 
            420                 425                 430         


Lys Ile Asp Leu Trp Ser Tyr Asn Ala Glu Leu Leu Val Ala Leu Glu 
        435                 440                 445             


Asn Gln His Thr Ile Asp Leu Thr Asp Ser Glu Met Asn Lys Leu Phe 
    450                 455                 460                 


Glu Arg Thr Arg Lys Gln Leu Arg Glu Asn Ala Glu Asp Met Gly Asn 
465                 470                 475                 480 


Gly Cys Phe Lys Ile Tyr His Lys Cys Asp Asn Ala Cys Ile Gly Ser 
                485                 490                 495     


Ile Arg Asn Gly Thr Tyr Asp His Asp Val Tyr Arg Asp Glu Ala Leu 
            500                 505                 510         


Asn Asn Arg Phe Gln Ile Lys Gly Val Glu Leu Lys Ser Gly Tyr Lys 
        515                 520                 525             


Asp Trp Ile Leu Trp Ile Ser Phe Ala Ile Ser Cys Phe Leu Leu Cys 
    530                 535                 540                 


Val Val Leu Leu Gly Phe Ile Met Trp Ala Cys Gln Lys Gly Asn Ile 
545                 550                 555                 560 


Arg Cys Asn Ile Cys Ile 
                565     


<210>  43
<211>  566
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MRK_H3_ConsensusB

<400>  43

Met Lys Thr Ile Ile Ala Leu Ser Tyr Ile Leu Cys Leu Val Phe Ala 
1               5                   10                  15      


Gln Lys Leu Pro Gly Asn Asp Asn Ser Thr Ala Thr Leu Cys Leu Gly 
            20                  25                  30          


His His Ala Val Pro Asn Gly Thr Ile Val Lys Thr Ile Thr Asn Asp 
        35                  40                  45              


Gln Ile Glu Val Thr Asn Ala Thr Glu Leu Val Gln Asn Ser Ser Thr 
    50                  55                  60                  


Gly Glu Ile Cys Asp Ser Pro His Gln Ile Leu Asp Gly Glu Asn Cys 
65                  70                  75                  80  


Thr Leu Ile Asp Ala Leu Leu Gly Asp Pro Gln Cys Asp Gly Phe Gln 
                85                  90                  95      


Asn Lys Lys Trp Asp Leu Phe Val Glu Arg Ser Lys Ala Tyr Ser Asn 
            100                 105                 110         


Cys Tyr Pro Tyr Asp Val Pro Asp Tyr Ala Ser Leu Arg Ser Leu Val 
        115                 120                 125             


Ala Ser Ser Gly Thr Leu Glu Phe Asn Asn Glu Ser Phe Asn Trp Thr 
    130                 135                 140                 


Gly Val Thr Gln Asn Gly Thr Ser Ser Ala Cys Ile Arg Arg Ser Asn 
145                 150                 155                 160 


Ser Ser Phe Phe Ser Arg Leu Asn Trp Leu Thr His Leu Asn Phe Lys 
                165                 170                 175     


Tyr Pro Ala Leu Asn Val Thr Met Pro Asn Asn Glu Gln Phe Asp Lys 
            180                 185                 190         


Leu Tyr Ile Trp Gly Val His His Pro Gly Thr Asp Lys Asp Gln Ile 
        195                 200                 205             


Phe Leu Tyr Ala Gln Ser Ser Gly Arg Ile Thr Val Ser Thr Lys Arg 
    210                 215                 220                 


Ser Gln Gln Ala Val Ile Pro Asn Ile Gly Ser Arg Pro Arg Ile Arg 
225                 230                 235                 240 


Asn Ile Pro Ser Arg Ile Ser Ile Tyr Trp Thr Ile Val Lys Pro Gly 
                245                 250                 255     


Asp Ile Leu Leu Ile Asn Ser Thr Gly Asn Leu Ile Ala Pro Arg Gly 
            260                 265                 270         


Tyr Phe Lys Ile Arg Ser Gly Lys Ser Ser Ile Met Arg Ser Asp Ala 
        275                 280                 285             


Pro Ile Gly Lys Cys Asn Ser Glu Cys Ile Thr Pro Asn Gly Ser Ile 
    290                 295                 300                 


Pro Asn Asp Lys Pro Phe Gln Asn Val Asn Arg Ile Thr Tyr Gly Ala 
305                 310                 315                 320 


Cys Pro Arg Tyr Val Lys Gln Ser Thr Leu Lys Leu Ala Thr Gly Met 
                325                 330                 335     


Arg Asn Val Pro Glu Lys Gln Thr Arg Gly Ile Phe Gly Ala Ile Ala 
            340                 345                 350         


Gly Phe Ile Glu Asn Gly Trp Glu Gly Met Val Asp Gly Trp Tyr Gly 
        355                 360                 365             


Phe Arg His Gln Asn Ser Glu Gly Arg Gly Gln Ala Ala Asp Leu Lys 
    370                 375                 380                 


Ser Thr Gln Ala Ala Ile Asp Gln Ile Asn Gly Lys Leu Asn Arg Leu 
385                 390                 395                 400 


Ile Gly Lys Thr Asn Glu Lys Phe His Gln Ile Glu Lys Glu Phe Ser 
                405                 410                 415     


Glu Val Glu Gly Arg Ile Gln Asp Leu Glu Lys Tyr Val Glu Asp Thr 
            420                 425                 430         


Lys Ile Asp Leu Trp Ser Tyr Asn Ala Glu Leu Leu Val Ala Leu Glu 
        435                 440                 445             


Asn Gln His Thr Ile Asp Leu Thr Asp Ser Glu Met Asn Lys Leu Phe 
    450                 455                 460                 


Glu Lys Thr Lys Lys Gln Leu Arg Glu Asn Ala Glu Asp Met Gly Asn 
465                 470                 475                 480 


Gly Cys Phe Lys Ile Tyr His Lys Cys Asp Asn Ala Cys Ile Gly Ser 
                485                 490                 495     


Ile Arg Asn Gly Thr Tyr Asp His Asp Val Tyr Arg Asp Glu Ala Leu 
            500                 505                 510         


Asn Asn Arg Phe Gln Ile Lys Gly Val Glu Leu Lys Ser Gly Tyr Lys 
        515                 520                 525             


Asp Trp Ile Leu Trp Ile Ser Phe Ala Ile Ser Cys Phe Leu Leu Cys 
    530                 535                 540                 


Val Ala Leu Leu Gly Phe Ile Met Trp Ala Cys Gln Lys Gly Asn Ile 
545                 550                 555                 560 


Arg Cys Asn Ile Cys Ile 
                565     


<210>  44
<211>  566
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MRK_H1_cot_all

<400>  44

Met Lys Ala Ile Leu Val Val Leu Leu Tyr Thr Phe Ala Thr Ala Asn 
1               5                   10                  15      


Ala Asp Thr Leu Cys Ile Gly Tyr His Ala Asn Asn Ser Thr Asp Thr 
            20                  25                  30          


Val Asp Thr Val Leu Glu Lys Asn Val Thr Val Thr His Ser Val Asn 
        35                  40                  45              


Leu Leu Glu Asp Lys His Asn Gly Lys Leu Cys Lys Leu Arg Gly Val 
    50                  55                  60                  


Ala Pro Leu His Leu Gly Lys Cys Asn Ile Ala Gly Trp Ile Leu Gly 
65                  70                  75                  80  


Asn Pro Glu Cys Glu Ser Leu Ser Thr Ala Ser Ser Trp Ser Tyr Ile 
                85                  90                  95      


Val Glu Thr Ser Ser Ser Asp Asn Gly Thr Cys Tyr Pro Gly Asp Phe 
            100                 105                 110         


Ile Asn Tyr Glu Glu Leu Arg Glu Gln Leu Ser Ser Val Ser Ser Phe 
        115                 120                 125             


Glu Arg Phe Glu Ile Phe Pro Lys Thr Ser Ser Trp Pro Asn His Asp 
    130                 135                 140                 


Ser Asn Lys Gly Val Thr Ala Ala Cys Pro His Ala Gly Ala Lys Ser 
145                 150                 155                 160 


Phe Tyr Lys Asn Leu Ile Trp Leu Val Lys Lys Gly Asn Ser Tyr Pro 
                165                 170                 175     


Lys Leu Ser Lys Ser Tyr Ile Asn Asp Lys Gly Lys Glu Val Leu Val 
            180                 185                 190         


Leu Trp Gly Ile His His Pro Ser Thr Thr Ala Asp Gln Gln Ser Leu 
        195                 200                 205             


Tyr Gln Asn Ala Asp Ala Tyr Val Phe Val Gly Thr Ser Arg Tyr Ser 
    210                 215                 220                 


Lys Lys Phe Lys Pro Glu Ile Ala Ile Arg Pro Lys Val Arg Asp Gln 
225                 230                 235                 240 


Glu Gly Arg Met Asn Tyr Tyr Trp Thr Leu Val Glu Pro Gly Asp Lys 
                245                 250                 255     


Ile Thr Phe Glu Ala Thr Gly Asn Leu Val Val Pro Arg Tyr Ala Phe 
            260                 265                 270         


Ala Met Glu Arg Asn Ala Gly Ser Gly Ile Ile Ile Ser Asp Thr Pro 
        275                 280                 285             


Val His Asp Cys Asn Thr Thr Cys Gln Thr Pro Lys Gly Ala Ile Asn 
    290                 295                 300                 


Thr Ser Leu Pro Phe Gln Asn Ile His Pro Ile Thr Ile Gly Lys Cys 
305                 310                 315                 320 


Pro Lys Tyr Val Lys Ser Thr Lys Leu Arg Leu Ala Thr Gly Leu Arg 
                325                 330                 335     


Asn Val Pro Ser Ile Gln Ser Arg Gly Leu Phe Gly Ala Ile Ala Gly 
            340                 345                 350         


Phe Ile Glu Gly Gly Trp Thr Gly Met Val Asp Gly Trp Tyr Gly Tyr 
        355                 360                 365             


His His Gln Asn Glu Gln Gly Ser Gly Tyr Ala Ala Asp Leu Lys Ser 
    370                 375                 380                 


Thr Gln Asn Ala Ile Asp Lys Ile Thr Asn Lys Val Asn Ser Val Ile 
385                 390                 395                 400 


Glu Lys Met Asn Thr Gln Phe Thr Ala Val Gly Lys Glu Phe Asn His 
                405                 410                 415     


Leu Glu Lys Arg Ile Glu Asn Leu Asn Lys Lys Val Asp Asp Gly Phe 
            420                 425                 430         


Leu Asp Ile Trp Thr Tyr Asn Ala Glu Leu Leu Val Leu Leu Glu Asn 
        435                 440                 445             


Glu Arg Thr Leu Asp Tyr His Asp Ser Asn Val Lys Asn Leu Tyr Glu 
    450                 455                 460                 


Lys Val Arg Asn Gln Leu Lys Asn Asn Ala Lys Glu Ile Gly Asn Gly 
465                 470                 475                 480 


Cys Phe Glu Phe Tyr His Lys Cys Asp Asn Thr Cys Met Glu Ser Val 
                485                 490                 495     


Lys Asn Gly Thr Tyr Asp Tyr Pro Lys Tyr Ser Glu Glu Ala Lys Leu 
            500                 505                 510         


Asn Arg Glu Lys Ile Asp Gly Val Lys Leu Glu Ser Thr Arg Ile Tyr 
        515                 520                 525             


Gln Ile Leu Ala Ile Tyr Ser Thr Val Ala Ser Ser Leu Val Leu Val 
    530                 535                 540                 


Val Ser Leu Gly Ala Ile Ser Phe Trp Met Cys Ser Asn Gly Ser Leu 
545                 550                 555                 560 


Gln Cys Arg Ile Cys Ile 
                565     


<210>  45
<211>  566
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MRK_H3_cot_all

<400>  45

Met Lys Thr Ile Ile Ala Leu Ser Tyr Ile Leu Cys Leu Val Phe Ala 
1               5                   10                  15      


Gln Lys Leu Pro Gly Asn Asp Asn Ser Thr Ala Thr Leu Cys Leu Gly 
            20                  25                  30          


His His Ala Val Pro Asn Gly Thr Ile Val Lys Thr Ile Thr Asn Asp 
        35                  40                  45              


Arg Ile Glu Val Thr Asn Ala Thr Glu Leu Val Gln Asn Ser Ser Ile 
    50                  55                  60                  


Gly Glu Ile Cys Asp Ser Pro His Gln Ile Leu Asp Gly Glu Asn Cys 
65                  70                  75                  80  


Thr Leu Ile Asp Ala Leu Leu Gly Asp Pro Gln Cys Asp Gly Phe Gln 
                85                  90                  95      


Asn Lys Lys Trp Asp Leu Phe Val Glu Arg Ser Lys Ala Tyr Ser Asn 
            100                 105                 110         


Cys Tyr Pro Tyr Asp Val Pro Asp Tyr Ala Ser Leu Arg Ser Leu Val 
        115                 120                 125             


Ala Ser Ser Gly Thr Leu Glu Phe Asn Asn Glu Ser Phe Asn Trp Thr 
    130                 135                 140                 


Gly Val Thr Gln Asn Gly Thr Ser Ser Ala Cys Ile Arg Arg Ser Asn 
145                 150                 155                 160 


Ser Ser Phe Phe Ser Arg Leu Asn Trp Leu Thr His Leu Asn Phe Lys 
                165                 170                 175     


Tyr Pro Ala Leu Asn Val Thr Met Pro Asn Asn Glu Gln Phe Asp Lys 
            180                 185                 190         


Leu Tyr Ile Trp Gly Val His His Pro Gly Thr Asp Lys Asp Gln Ile 
        195                 200                 205             


Phe Leu Tyr Ala Gln Ser Ser Gly Arg Ile Thr Val Ser Thr Lys Arg 
    210                 215                 220                 


Ser Gln Gln Ala Val Ile Pro Asn Ile Gly Ser Arg Pro Arg Ile Arg 
225                 230                 235                 240 


Asn Ile Pro Ser Arg Ile Ser Ile Tyr Trp Thr Ile Val Lys Pro Gly 
                245                 250                 255     


Asp Ile Leu Leu Ile Asn Ser Thr Gly Asn Leu Ile Ala Pro Arg Gly 
            260                 265                 270         


Tyr Phe Lys Ile Arg Ser Gly Lys Ser Ser Ile Met Arg Ser Asp Ala 
        275                 280                 285             


Pro Ile Gly Lys Cys Lys Ser Glu Cys Ile Thr Pro Asn Gly Ser Ile 
    290                 295                 300                 


Pro Asn Asp Lys Pro Phe Gln Asn Val Asn Arg Ile Thr Tyr Gly Ala 
305                 310                 315                 320 


Cys Pro Arg Tyr Val Lys Gln Ser Thr Leu Lys Leu Ala Thr Gly Met 
                325                 330                 335     


Arg Asn Val Pro Glu Lys Gln Thr Arg Gly Ile Phe Gly Ala Ile Ala 
            340                 345                 350         


Gly Phe Ile Glu Asn Gly Trp Glu Gly Met Val Asp Gly Trp Tyr Gly 
        355                 360                 365             


Phe Arg His Gln Asn Ser Glu Gly Arg Gly Gln Ala Ala Asp Leu Lys 
    370                 375                 380                 


Ser Thr Gln Ala Ala Ile Asp Gln Ile Asn Gly Lys Leu Asn Arg Leu 
385                 390                 395                 400 


Ile Gly Lys Thr Asn Glu Lys Phe His Gln Ile Glu Lys Glu Phe Ser 
                405                 410                 415     


Glu Val Glu Gly Arg Ile Gln Asp Leu Glu Lys Tyr Val Glu Asp Thr 
            420                 425                 430         


Lys Ile Asp Leu Trp Ser Tyr Asn Ala Glu Leu Leu Val Ala Leu Glu 
        435                 440                 445             


Asn Gln His Thr Ile Asp Leu Thr Asp Ser Glu Met Asn Lys Leu Phe 
    450                 455                 460                 


Glu Lys Thr Lys Lys Gln Leu Arg Glu Asn Ala Glu Asp Met Gly Asn 
465                 470                 475                 480 


Gly Cys Phe Lys Ile Tyr His Lys Cys Asp Asn Ala Cys Ile Gly Ser 
                485                 490                 495     


Ile Arg Asn Gly Thr Tyr Asp His Asp Val Tyr Arg Asp Glu Ala Leu 
            500                 505                 510         


Asn Asn Arg Phe Gln Ile Lys Gly Val Glu Leu Lys Ser Gly Tyr Lys 
        515                 520                 525             


Asp Trp Ile Leu Trp Ile Ser Phe Ala Ile Ser Cys Phe Leu Leu Cys 
    530                 535                 540                 


Val Ala Leu Leu Gly Phe Ile Met Trp Ala Cys Gln Lys Gly Asn Ile 
545                 550                 555                 560 


Arg Cys Asn Ile Cys Ile 
                565     


<210>  46
<211>  565
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MRK_sH1_Con_v2

<400>  46

Met Lys Val Lys Leu Leu Val Leu Leu Cys Thr Phe Thr Ala Thr Tyr 
1               5                   10                  15      


Ala Asp Thr Ile Cys Ile Gly Tyr His Ala Asn Asn Ser Thr Asp Thr 
            20                  25                  30          


Val Asp Thr Val Leu Glu Lys Asn Val Thr Val Thr His Ser Val Asn 
        35                  40                  45              


Leu Leu Glu Asn Ser His Asn Gly Lys Leu Cys Leu Leu Lys Gly Ile 
    50                  55                  60                  


Ala Pro Leu Gln Leu Gly Asn Cys Ser Val Ala Gly Trp Ile Leu Gly 
65                  70                  75                  80  


Asn Pro Glu Cys Glu Leu Leu Ile Ser Lys Glu Ser Trp Ser Tyr Ile 
                85                  90                  95      


Val Glu Lys Pro Asn Pro Glu Asn Gly Thr Cys Tyr Pro Gly His Phe 
            100                 105                 110         


Ala Asp Tyr Glu Glu Leu Arg Glu Gln Leu Ser Ser Val Ser Ser Phe 
        115                 120                 125             


Glu Arg Phe Glu Ile Phe Pro Lys Glu Ser Ser Trp Pro Asn His Thr 
    130                 135                 140                 


Val Thr Gly Val Ser Ala Ser Cys Ser His Asn Gly Glu Ser Ser Phe 
145                 150                 155                 160 


Tyr Arg Asn Leu Leu Trp Leu Thr Gly Lys Asn Gly Leu Tyr Pro Asn 
                165                 170                 175     


Leu Ser Lys Ser Tyr Ala Asn Asn Lys Glu Lys Glu Val Leu Val Leu 
            180                 185                 190         


Trp Gly Val His His Pro Pro Asn Ile Gly Asp Gln Lys Ala Leu Tyr 
        195                 200                 205             


His Thr Glu Asn Ala Tyr Val Ser Val Val Ser Ser His Tyr Ser Arg 
    210                 215                 220                 


Lys Phe Thr Pro Glu Ile Ala Lys Arg Pro Lys Val Arg Asp Gln Glu 
225                 230                 235                 240 


Gly Arg Ile Asn Tyr Tyr Trp Thr Leu Leu Glu Pro Gly Asp Thr Ile 
                245                 250                 255     


Ile Phe Glu Ala Asn Gly Asn Leu Ile Ala Pro Arg Tyr Ala Phe Ala 
            260                 265                 270         


Leu Ser Arg Gly Phe Gly Ser Gly Ile Ile Asn Ser Asn Ala Pro Met 
        275                 280                 285             


Asp Lys Cys Asp Ala Lys Cys Gln Thr Pro Gln Gly Ala Ile Asn Ser 
    290                 295                 300                 


Ser Leu Pro Phe Gln Asn Val His Pro Val Thr Ile Gly Glu Cys Pro 
305                 310                 315                 320 


Lys Tyr Val Arg Ser Ala Lys Leu Arg Met Val Thr Gly Leu Arg Asn 
                325                 330                 335     


Ile Pro Ser Ile Gln Ser Arg Gly Leu Phe Gly Ala Ile Ala Gly Phe 
            340                 345                 350         


Ile Glu Gly Gly Trp Thr Gly Met Val Asp Gly Trp Tyr Gly Tyr His 
        355                 360                 365             


His Gln Asn Glu Gln Gly Ser Gly Tyr Ala Ala Asp Gln Lys Ser Thr 
    370                 375                 380                 


Gln Asn Ala Ile Asn Gly Ile Thr Asn Lys Val Asn Ser Val Ile Glu 
385                 390                 395                 400 


Lys Met Asn Thr Gln Phe Thr Ala Val Gly Lys Glu Phe Asn Lys Leu 
                405                 410                 415     


Glu Arg Arg Met Glu Asn Leu Asn Lys Lys Val Asp Asp Gly Phe Ile 
            420                 425                 430         


Asp Ile Trp Thr Tyr Asn Ala Glu Leu Leu Val Leu Leu Glu Asn Glu 
        435                 440                 445             


Arg Thr Leu Asp Phe His Asp Ser Asn Val Lys Asn Leu Tyr Glu Lys 
    450                 455                 460                 


Val Lys Ser Gln Leu Lys Asn Asn Ala Lys Glu Ile Gly Asn Gly Cys 
465                 470                 475                 480 


Phe Glu Phe Tyr His Lys Cys Asn Asp Glu Cys Met Glu Ser Val Lys 
                485                 490                 495     


Asn Gly Thr Tyr Asp Tyr Pro Lys Tyr Ser Glu Glu Ser Lys Leu Asn 
            500                 505                 510         


Arg Glu Lys Ile Asp Gly Val Lys Leu Glu Ser Met Gly Val Tyr Gln 
        515                 520                 525             


Ile Leu Ala Ile Tyr Ser Thr Val Ala Ser Ser Leu Val Leu Leu Val 
    530                 535                 540                 


Ser Leu Gly Ala Ile Ser Phe Trp Met Cys Ser Asn Gly Ser Leu Gln 
545                 550                 555                 560 


Cys Arg Ile Cys Ile 
                565 


<210>  47
<211>  558
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MRK_sH1_Con_ecto

<400>  47

Met Lys Val Lys Leu Leu Val Leu Leu Cys Thr Phe Thr Ala Thr Tyr 
1               5                   10                  15      


Ala Asp Thr Ile Cys Ile Gly Tyr His Ala Asn Asn Ser Thr Asp Thr 
            20                  25                  30          


Val Asp Thr Val Leu Glu Lys Asn Val Thr Val Thr His Ser Val Asn 
        35                  40                  45              


Leu Leu Glu Asp Ser His Asn Gly Lys Leu Cys Leu Leu Lys Gly Ile 
    50                  55                  60                  


Ala Pro Leu Gln Leu Gly Asn Cys Ser Val Ala Gly Trp Ile Leu Gly 
65                  70                  75                  80  


Asn Pro Glu Cys Glu Leu Leu Ile Ser Lys Glu Ser Trp Ser Tyr Ile 
                85                  90                  95      


Val Glu Thr Pro Asn Pro Glu Asn Gly Thr Cys Tyr Pro Gly Tyr Phe 
            100                 105                 110         


Ala Asp Tyr Glu Glu Leu Arg Glu Gln Leu Ser Ser Val Ser Ser Phe 
        115                 120                 125             


Glu Arg Phe Glu Ile Phe Pro Lys Glu Ser Ser Trp Pro Asn His Thr 
    130                 135                 140                 


Val Thr Gly Val Ser Ala Ser Cys Ser His Asn Gly Lys Ser Ser Phe 
145                 150                 155                 160 


Tyr Arg Asn Leu Leu Trp Leu Thr Gly Lys Asn Gly Leu Tyr Pro Asn 
                165                 170                 175     


Leu Ser Lys Ser Tyr Ala Asn Asn Lys Glu Lys Glu Val Leu Val Leu 
            180                 185                 190         


Trp Gly Val His His Pro Pro Asn Ile Gly Asp Gln Arg Ala Leu Tyr 
        195                 200                 205             


His Thr Glu Asn Ala Tyr Val Ser Val Val Ser Ser His Tyr Ser Arg 
    210                 215                 220                 


Arg Phe Thr Pro Glu Ile Ala Lys Arg Pro Lys Val Arg Asp Gln Glu 
225                 230                 235                 240 


Gly Arg Ile Asn Tyr Tyr Trp Thr Leu Leu Glu Pro Gly Asp Thr Ile 
                245                 250                 255     


Ile Phe Glu Ala Asn Gly Asn Leu Ile Ala Pro Arg Tyr Ala Phe Ala 
            260                 265                 270         


Leu Ser Arg Gly Phe Gly Ser Gly Ile Ile Thr Ser Asn Ala Pro Met 
        275                 280                 285             


Asp Glu Cys Asp Ala Lys Cys Gln Thr Pro Gln Gly Ala Ile Asn Ser 
    290                 295                 300                 


Ser Leu Pro Phe Gln Asn Val His Pro Val Thr Ile Gly Glu Cys Pro 
305                 310                 315                 320 


Lys Tyr Val Arg Ser Ala Lys Leu Arg Met Val Thr Gly Leu Arg Asn 
                325                 330                 335     


Ile Pro Ser Ile Gln Ser Arg Gly Leu Phe Gly Ala Ile Ala Gly Phe 
            340                 345                 350         


Ile Glu Gly Gly Trp Thr Gly Met Val Asp Gly Trp Tyr Gly Tyr His 
        355                 360                 365             


His Gln Asn Glu Gln Gly Ser Gly Tyr Ala Ala Asp Gln Lys Ser Thr 
    370                 375                 380                 


Gln Asn Ala Ile Asn Gly Ile Thr Asn Lys Val Asn Ser Val Ile Glu 
385                 390                 395                 400 


Lys Met Asn Thr Gln Phe Thr Ala Val Gly Lys Glu Phe Asn Lys Leu 
                405                 410                 415     


Glu Arg Arg Met Glu Asn Leu Asn Lys Lys Val Asp Asp Gly Phe Leu 
            420                 425                 430         


Asp Ile Trp Thr Tyr Asn Ala Glu Leu Leu Val Leu Leu Glu Asn Glu 
        435                 440                 445             


Arg Thr Leu Asp Phe His Asp Ser Asn Val Lys Asn Leu Tyr Glu Lys 
    450                 455                 460                 


Val Lys Ser Gln Leu Lys Asn Asn Ala Lys Glu Ile Gly Asn Gly Cys 
465                 470                 475                 480 


Phe Glu Phe Tyr His Lys Cys Asn Asp Glu Cys Met Glu Ser Val Lys 
                485                 490                 495     


Asn Gly Thr Tyr Asp Tyr Pro Lys Tyr Ser Glu Glu Ser Lys Leu Asn 
            500                 505                 510         


Arg Glu Lys Ile Asp Gly Val Lys Leu Glu Ser Met Gly Val Gly Ser 
        515                 520                 525             


Ala Gly Ser Ala Gly Tyr Ile Pro Glu Ala Pro Arg Asp Gly Gln Ala 
    530                 535                 540                 


Tyr Val Arg Lys Asp Gly Glu Trp Val Leu Ser Thr Phe Leu 
545                 550                 555             


<210>  48
<211>  231
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MRK_sH1_Con_RBD

<400>  48

Met Lys Val Lys Leu Leu Val Leu Leu Cys Thr Phe Thr Ala Thr Tyr 
1               5                   10                  15      


Ala Gly Ile Ala Pro Leu Gln Leu Gly Asn Cys Ser Val Ala Gly Trp 
            20                  25                  30          


Ile Leu Gly Asn Pro Glu Cys Glu Leu Leu Ile Ser Lys Glu Ser Trp 
        35                  40                  45              


Ser Tyr Ile Val Glu Thr Pro Asn Pro Glu Asn Gly Thr Cys Tyr Pro 
    50                  55                  60                  


Gly Tyr Phe Ala Asp Tyr Glu Glu Leu Arg Glu Gln Leu Ser Ser Val 
65                  70                  75                  80  


Ser Ser Phe Glu Arg Phe Glu Ile Phe Pro Lys Glu Ser Ser Trp Pro 
                85                  90                  95      


Asn His Thr Val Thr Gly Val Ser Ala Ser Cys Ser His Asn Gly Lys 
            100                 105                 110         


Ser Ser Phe Tyr Arg Asn Leu Leu Trp Leu Thr Gly Lys Asn Gly Leu 
        115                 120                 125             


Tyr Pro Asn Leu Ser Lys Ser Tyr Ala Asn Asn Lys Glu Lys Glu Val 
    130                 135                 140                 


Leu Val Leu Trp Gly Val His His Pro Pro Asn Ile Gly Asp Gln Arg 
145                 150                 155                 160 


Ala Leu Tyr His Thr Glu Asn Ala Tyr Val Ser Val Val Ser Ser His 
                165                 170                 175     


Tyr Ser Arg Arg Phe Thr Pro Glu Ile Ala Lys Arg Pro Lys Val Arg 
            180                 185                 190         


Asp Gln Glu Gly Arg Ile Asn Tyr Tyr Trp Thr Leu Leu Glu Pro Gly 
        195                 200                 205             


Asp Thr Ile Ile Phe Glu Ala Asn Gly Asn Leu Ile Ala Pro Arg Tyr 
    210                 215                 220                 


Ala Phe Ala Leu Ser Arg Gly 
225                 230     


<210>  49
<211>  560
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MRK_pH1_Con_ecto

<400>  49

Met Lys Ala Ile Leu Val Val Leu Leu Tyr Thr Phe Ala Thr Ala Asn 
1               5                   10                  15      


Ala Asp Thr Leu Cys Ile Gly Tyr His Ala Asn Asn Ser Thr Asp Thr 
            20                  25                  30          


Val Asp Thr Val Leu Glu Lys Asn Val Thr Val Thr His Ser Val Asn 
        35                  40                  45              


Leu Leu Glu Asp Lys His Asn Gly Lys Leu Cys Lys Leu Arg Gly Val 
    50                  55                  60                  


Ala Pro Leu His Leu Gly Lys Cys Asn Ile Ala Gly Trp Ile Leu Gly 
65                  70                  75                  80  


Asn Pro Glu Cys Glu Ser Leu Ser Thr Ala Ser Ser Trp Ser Tyr Ile 
                85                  90                  95      


Val Glu Thr Ser Ser Ser Asp Asn Gly Thr Cys Tyr Pro Gly Asp Phe 
            100                 105                 110         


Ile Asp Tyr Glu Glu Leu Arg Glu Gln Leu Ser Ser Val Ser Ser Phe 
        115                 120                 125             


Glu Arg Phe Glu Ile Phe Pro Lys Thr Ser Ser Trp Pro Asn His Asp 
    130                 135                 140                 


Ser Asn Lys Gly Val Thr Ala Ala Cys Pro His Ala Gly Ala Lys Ser 
145                 150                 155                 160 


Phe Tyr Lys Asn Leu Ile Trp Leu Val Lys Lys Gly Asn Ser Tyr Pro 
                165                 170                 175     


Lys Leu Ser Lys Ser Tyr Ile Asn Asp Lys Gly Lys Glu Val Leu Val 
            180                 185                 190         


Leu Trp Gly Ile His His Pro Ser Thr Ser Ala Asp Gln Gln Ser Leu 
        195                 200                 205             


Tyr Gln Asn Ala Asp Ala Tyr Val Phe Val Gly Thr Ser Arg Tyr Ser 
    210                 215                 220                 


Lys Lys Phe Lys Pro Glu Ile Ala Ile Arg Pro Lys Val Arg Asp Gln 
225                 230                 235                 240 


Glu Gly Arg Met Asn Tyr Tyr Trp Thr Leu Val Glu Pro Gly Asp Lys 
                245                 250                 255     


Ile Thr Phe Glu Ala Thr Gly Asn Leu Val Val Pro Arg Tyr Ala Phe 
            260                 265                 270         


Ala Met Glu Arg Asn Ala Gly Ser Gly Ile Ile Ile Ser Asp Thr Pro 
        275                 280                 285             


Val His Asp Cys Asn Thr Thr Cys Gln Thr Pro Lys Gly Ala Ile Asn 
    290                 295                 300                 


Thr Ser Leu Pro Phe Gln Asn Ile His Pro Ile Thr Ile Gly Lys Cys 
305                 310                 315                 320 


Pro Lys Tyr Val Lys Ser Thr Lys Leu Arg Leu Ala Thr Gly Leu Arg 
                325                 330                 335     


Asn Val Pro Ser Ile Gln Ser Arg Gly Leu Phe Gly Ala Ile Ala Gly 
            340                 345                 350         


Phe Ile Glu Gly Gly Trp Thr Gly Met Val Asp Gly Trp Tyr Gly Tyr 
        355                 360                 365             


His His Gln Asn Glu Gln Gly Ser Gly Tyr Ala Ala Asp Leu Lys Ser 
    370                 375                 380                 


Thr Gln Asn Ala Ile Asp Lys Ile Thr Asn Lys Val Asn Ser Val Ile 
385                 390                 395                 400 


Glu Lys Met Asn Thr Gln Phe Thr Ala Val Gly Lys Glu Phe Asn His 
                405                 410                 415     


Leu Glu Lys Arg Ile Glu Asn Leu Asn Lys Lys Val Asp Asp Gly Phe 
            420                 425                 430         


Leu Asp Ile Trp Thr Tyr Asn Ala Glu Leu Leu Val Leu Leu Glu Asn 
        435                 440                 445             


Glu Arg Thr Leu Asp Tyr His Asp Ser Asn Val Lys Asn Leu Tyr Glu 
    450                 455                 460                 


Lys Val Arg Ser Gln Leu Lys Asn Asn Ala Lys Glu Ile Gly Asn Gly 
465                 470                 475                 480 


Cys Phe Glu Phe Tyr His Lys Cys Asp Asn Thr Cys Met Glu Ser Val 
                485                 490                 495     


Lys Asn Gly Thr Tyr Asp Tyr Pro Lys Tyr Ser Glu Glu Ala Lys Leu 
            500                 505                 510         


Asn Arg Glu Glu Ile Asp Gly Val Lys Leu Glu Ser Thr Arg Ile Gly 
        515                 520                 525             


Ser Ala Gly Ser Ala Gly Tyr Ile Pro Glu Ala Pro Arg Asp Gly Gln 
    530                 535                 540                 


Ala Tyr Val Arg Lys Asp Gly Glu Trp Val Leu Leu Ser Thr Phe Leu 
545                 550                 555                 560 


<210>  50
<211>  233
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MRK_pH1_Con_RBD

<400>  50

Met Lys Val Lys Leu Leu Val Leu Leu Cys Thr Phe Thr Ala Thr Tyr 
1               5                   10                  15      


Ala Gly Val Ala Pro Leu His Leu Gly Lys Cys Asn Ile Ala Gly Trp 
            20                  25                  30          


Ile Leu Gly Asn Pro Glu Cys Glu Ser Leu Ser Thr Ala Ser Ser Trp 
        35                  40                  45              


Ser Tyr Ile Val Glu Thr Ser Ser Ser Asp Asn Gly Thr Cys Tyr Pro 
    50                  55                  60                  


Gly Asp Phe Ile Asp Tyr Glu Glu Leu Arg Glu Gln Leu Ser Ser Val 
65                  70                  75                  80  


Ser Ser Phe Glu Arg Phe Glu Ile Phe Pro Lys Thr Ser Ser Trp Pro 
                85                  90                  95      


Asn His Asp Ser Asn Lys Gly Val Thr Ala Ala Cys Pro His Ala Gly 
            100                 105                 110         


Ala Lys Ser Phe Tyr Lys Asn Leu Ile Trp Leu Val Lys Lys Gly Asn 
        115                 120                 125             


Ser Tyr Pro Lys Leu Ser Lys Ser Tyr Ile Asn Asp Lys Gly Lys Glu 
    130                 135                 140                 


Val Leu Val Leu Trp Gly Ile His His Pro Ser Thr Ser Ala Asp Gln 
145                 150                 155                 160 


Gln Ser Leu Tyr Gln Asn Ala Asp Ala Tyr Val Phe Val Gly Thr Ser 
                165                 170                 175     


Arg Tyr Ser Lys Lys Phe Lys Pro Glu Ile Ala Ile Arg Pro Lys Val 
            180                 185                 190         


Arg Asp Gln Glu Gly Arg Met Asn Tyr Tyr Trp Thr Leu Val Glu Pro 
        195                 200                 205             


Gly Asp Lys Ile Thr Phe Glu Ala Thr Gly Asn Leu Val Val Pro Arg 
    210                 215                 220                 


Tyr Ala Phe Ala Met Glu Arg Asn Ala 
225                 230             


<210>  51
<211>  562
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  eH1HA_d5v1

<400>  51

Met Glu Thr Pro Ala Gln Leu Leu Phe Leu Leu Leu Leu Trp Leu Pro 
1               5                   10                  15      


Asp Thr Thr Gly Asp Thr Ile Cys Ile Gly Tyr His Ala Asn Asn Ser 
            20                  25                  30          


Thr Asp Thr Val Asp Thr Val Leu Glu Lys Asn Val Thr Val Thr His 
        35                  40                  45              


Ser Val Asn Leu Leu Glu Asp Ser His Asn Gly Lys Leu Cys Arg Leu 
    50                  55                  60                  


Lys Gly Ile Ala Pro Leu Gln Leu Gly Lys Cys Asn Ile Ala Gly Trp 
65                  70                  75                  80  


Leu Leu Gly Asn Pro Glu Cys Asp Pro Leu Pro Pro Met Lys Ser Trp 
                85                  90                  95      


Ser Tyr Ile Val Glu Thr Pro Asn Ser Glu Asn Gly Ile Cys Tyr Pro 
            100                 105                 110         


Gly Asp Phe Ile Asp Tyr Glu Glu Leu Arg Glu Gln Leu Ser Ser Val 
        115                 120                 125             


Ser Ser Phe Glu Arg Phe Glu Ile Phe Pro Lys Gly Ser Ser Trp Pro 
    130                 135                 140                 


Asn His Asn Thr Asn Gly Val Thr Ala Ala Cys Ser His Glu Gly Lys 
145                 150                 155                 160 


Asn Ser Phe Tyr Arg Asn Leu Leu Trp Leu Thr Lys Lys Glu Gly Leu 
                165                 170                 175     


Tyr Pro Asn Leu Glu Asn Ser Tyr Val Asn Lys Lys Glu Lys Glu Val 
            180                 185                 190         


Leu Val Leu Trp Gly Ile His His Pro Ser Asn Asn Lys Glu Gln Gln 
        195                 200                 205             


Asn Leu Tyr Gln Asn Glu Asn Ala Tyr Val Ser Val Val Thr Ser Asn 
    210                 215                 220                 


Tyr Asn Arg Arg Phe Thr Pro Glu Ile Ala Glu Arg Pro Lys Val Arg 
225                 230                 235                 240 


Asp Gln Ala Gly Arg Met Asn Tyr Tyr Trp Thr Leu Leu Lys Pro Gly 
                245                 250                 255     


Asp Thr Ile Ile Phe Glu Ala Asn Gly Asn Leu Ile Ala Pro Met Tyr 
            260                 265                 270         


Ala Phe Ala Leu Ser Arg Gly Phe Gly Ser Gly Ile Ile Thr Ser Asn 
        275                 280                 285             


Ala Ser Met His Glu Cys Asn Thr Lys Cys Gln Thr Pro Leu Gly Ala 
    290                 295                 300                 


Ile Asn Ser Ser Leu Pro Tyr Gln Asn Ile His Pro Val Thr Ile Gly 
305                 310                 315                 320 


Glu Cys Pro Lys Tyr Val Arg Ser Ala Lys Leu Arg Met Val Thr Gly 
                325                 330                 335     


Leu Arg Asn Ile Pro Ser Ile Gln Ser Arg Gly Leu Phe Gly Ala Ile 
            340                 345                 350         


Ala Gly Phe Ile Glu Gly Gly Trp Thr Gly Met Ile Asp Gly Trp Tyr 
        355                 360                 365             


Gly Tyr His His Gln Asn Glu Gln Gly Ser Gly Tyr Ala Ala Asp Gln 
    370                 375                 380                 


Lys Ser Thr Gln Asn Ala Ile Asn Gly Ile Thr Asn Lys Val Asn Thr 
385                 390                 395                 400 


Val Ile Glu Lys Met Asn Ile Gln Phe Thr Ala Val Gly Lys Glu Phe 
                405                 410                 415     


Asn Lys Leu Glu Lys Arg Met Glu Asn Leu Asn Lys Lys Val Asp Asp 
            420                 425                 430         


Gly Phe Leu Asp Ile Trp Thr Tyr Asn Ala Glu Leu Leu Val Leu Leu 
        435                 440                 445             


Glu Asn Glu Arg Thr Leu Asp Phe His Asp Ser Asn Val Lys Asn Leu 
    450                 455                 460                 


Tyr Glu Lys Val Lys Ser Gln Leu Lys Asn Asn Ala Lys Glu Ile Gly 
465                 470                 475                 480 


Asn Gly Cys Phe Glu Phe Tyr His Lys Cys Asp Asn Glu Cys Met Glu 
                485                 490                 495     


Ser Val Arg Asn Gly Thr Tyr Asp Tyr Pro Lys Tyr Ser Glu Glu Ser 
            500                 505                 510         


Lys Leu Asn Arg Glu Lys Val Asp Gly Val Lys Leu Glu Ser Met Gly 
        515                 520                 525             


Ile Gly Ser Ala Gly Ser Ala Gly Tyr Ile Pro Glu Ala Pro Arg Asp 
    530                 535                 540                 


Gly Gln Ala Tyr Val Arg Lys Asp Gly Glu Trp Val Leu Leu Ser Thr 
545                 550                 555                 560 


Phe Leu 
        


<210>  52
<211>  562
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  eH1HA_d5v2

<400>  52

Met Glu Thr Pro Ala Gln Leu Leu Phe Leu Leu Leu Leu Trp Leu Pro 
1               5                   10                  15      


Asp Arg Arg Gly Asp Thr Ile Cys Ile Gly Tyr His Ala Asn Asn Ser 
            20                  25                  30          


Thr Asp Thr Val Asp Thr Val Leu Glu Lys Asn Val Thr Val Thr His 
        35                  40                  45              


Ser Val Asn Leu Leu Glu Asp Ser His Asn Gly Lys Leu Cys Arg Leu 
    50                  55                  60                  


Lys Gly Ile Ala Pro Leu Gln Leu Gly Lys Cys Asn Ile Ala Gly Trp 
65                  70                  75                  80  


Leu Leu Gly Asn Pro Glu Cys Asp Pro Leu Pro Pro Met Lys Ser Trp 
                85                  90                  95      


Ser Tyr Ile Val Glu Thr Pro Asn Ser Glu Asn Gly Ile Cys Tyr Pro 
            100                 105                 110         


Gly Asp Phe Ile Asp Tyr Glu Glu Leu Arg Glu Gln Leu Ser Ser Val 
        115                 120                 125             


Ser Ser Phe Glu Arg Phe Glu Ile Phe Pro Lys Gly Ser Ser Trp Pro 
    130                 135                 140                 


Asn His Thr Thr Asn Gly Val Thr Ala Ala Cys Ser His Glu Gly Lys 
145                 150                 155                 160 


Asn Ser Phe Tyr Arg Asn Leu Leu Trp Leu Thr Lys Lys Glu Gly Ser 
                165                 170                 175     


Tyr Pro Asn Leu Lys Asn Ser Tyr Val Asn Lys Lys Glu Lys Glu Val 
            180                 185                 190         


Leu Val Leu Trp Gly Ile His His Pro Ser Asn Ser Lys Glu Gln Gln 
        195                 200                 205             


Asn Leu Tyr Gln Asn Glu Asn Ala His Val Ser Val Val Thr Ser Asn 
    210                 215                 220                 


Tyr Asn Arg Arg Phe Thr Pro Glu Ile Ala Glu Arg Pro Lys Val Arg 
225                 230                 235                 240 


Asp Gln Ala Gly Arg Met Asn Tyr Tyr Trp Thr Leu Leu Lys Pro Gly 
                245                 250                 255     


Asp Thr Ile Ile Phe Glu Ala Asp Gly Asn Leu Ile Ala Pro Met Tyr 
            260                 265                 270         


Ala Phe Ala Leu Ser Arg Gly Phe Gly Ser Gly Ile Ile Thr Ser Asn 
        275                 280                 285             


Ala Ser Met His Glu Cys Asn Thr Lys Cys Gln Thr Pro Leu Gly Ala 
    290                 295                 300                 


Ile Asn Ser Ser Leu Pro Tyr Gln Asn Ile His Pro Val Thr Ile Gly 
305                 310                 315                 320 


Glu Cys Pro Lys Tyr Val Arg Ser Ala Lys Leu Arg Met Val Thr Gly 
                325                 330                 335     


Leu Arg Asn Ile Pro Ser Ile Gln Ser Arg Gly Leu Phe Gly Ala Ile 
            340                 345                 350         


Ala Gly Phe Ile Glu Gly Gly Trp Thr Gly Met Ile Asp Gly Trp Tyr 
        355                 360                 365             


Gly Tyr His His Gln Asn Glu Gln Gly Ser Gly Tyr Ala Ala Asp Gln 
    370                 375                 380                 


Lys Ser Thr Gln Asn Ala Ile Asn Gly Ile Thr Asn Lys Val Asn Thr 
385                 390                 395                 400 


Val Ile Glu Lys Met Asn Ile Gln Phe Thr Ala Val Gly Lys Glu Phe 
                405                 410                 415     


Asn Lys Leu Glu Lys Arg Met Glu Asn Leu Asn Lys Lys Val Asp Asp 
            420                 425                 430         


Gly Phe Leu Asp Ile Trp Thr Tyr Asn Ala Glu Leu Leu Val Leu Leu 
        435                 440                 445             


Glu Asn Glu Arg Thr Leu Asp Phe His Asp Ser Asn Val Lys Asn Leu 
    450                 455                 460                 


Tyr Glu Lys Val Lys Ser Gln Leu Lys Asn Asn Ala Lys Glu Ile Gly 
465                 470                 475                 480 


Asn Gly Cys Phe Glu Phe Tyr His Lys Cys Asp Asn Glu Cys Met Glu 
                485                 490                 495     


Ser Val Arg Asn Gly Thr Tyr Asp Tyr Pro Lys Tyr Ser Glu Glu Ser 
            500                 505                 510         


Lys Leu Asn Arg Glu Lys Val Asp Gly Val Lys Leu Glu Ser Met Gly 
        515                 520                 525             


Ile Gly Ser Ala Gly Ser Ala Gly Tyr Ile Pro Glu Ala Pro Arg Asp 
    530                 535                 540                 


Gly Gln Ala Tyr Val Arg Lys Asp Gly Glu Trp Val Leu Leu Ser Thr 
545                 550                 555                 560 


Phe Leu 
        


<210>  53
<211>  562
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  eH1HA_d5v3

<400>  53

Met Glu Thr Pro Ala Gln Leu Leu Phe Leu Leu Leu Leu Trp Leu Pro 
1               5                   10                  15      


Asp Thr Thr Gly Asp Thr Ile Cys Ile Gly Tyr His Ala Asn Asn Ser 
            20                  25                  30          


Thr Asp Thr Val Asp Thr Val Leu Glu Lys Asn Val Thr Val Thr His 
        35                  40                  45              


Ser Val Asn Leu Leu Glu Asp Ser His Asn Gly Lys Leu Cys Arg Leu 
    50                  55                  60                  


Lys Gly Ile Ala Pro Leu Gln Leu Gly Lys Cys Asn Ile Ala Gly Trp 
65                  70                  75                  80  


Leu Leu Gly Asn Pro Glu Cys Asp Pro Leu Pro Pro Met Lys Ser Trp 
                85                  90                  95      


Ser Tyr Ile Val Glu Thr Pro Asn Ser Glu Asn Gly Ile Cys Tyr Pro 
            100                 105                 110         


Gly Asp Phe Ile Asp Tyr Glu Glu Leu Arg Glu Gln Leu Ser Ser Val 
        115                 120                 125             


Ser Ser Phe Glu Arg Phe Glu Ile Phe Pro Lys Gly Ser Ser Trp Pro 
    130                 135                 140                 


Asp His Asn Thr Asn Gly Val Thr Ala Ala Cys Ser His Glu Gly Lys 
145                 150                 155                 160 


Asn Ser Phe Tyr Arg Asn Leu Leu Trp Leu Thr Glu Lys Lys Gly Ser 
                165                 170                 175     


Tyr Pro Asn Leu Lys Asn Pro Tyr Val Asn Lys Lys Glu Lys Glu Val 
            180                 185                 190         


Leu Val Leu Trp Gly Ile His His Pro Ser Asn Ser Lys Glu Gln Gln 
        195                 200                 205             


Asn Leu Tyr Arg Asn Glu Asn Ala Tyr Val Ser Val Val Thr Ser Asn 
    210                 215                 220                 


Tyr Asn Arg Arg Phe Thr Pro Glu Ile Ala Glu Arg Pro Lys Val Arg 
225                 230                 235                 240 


Asp Gln Ala Gly Arg Met Asn Tyr Tyr Trp Thr Leu Leu Lys Pro Gly 
                245                 250                 255     


Asp Thr Ile Ile Phe Glu Ala Asn Gly Asn Leu Ile Ala Pro Met Tyr 
            260                 265                 270         


Ala Phe Ala Leu Ser Arg Gly Phe Gly Ser Gly Ile Ile Thr Ser Asn 
        275                 280                 285             


Ala Ser Met His Glu Cys Asn Thr Lys Cys Gln Thr Pro Leu Gly Ala 
    290                 295                 300                 


Ile Asn Ser Ser Leu Pro Tyr Gln Asn Ile His Pro Val Thr Ile Gly 
305                 310                 315                 320 


Glu Cys Pro Lys Tyr Val Arg Ser Ala Lys Leu Arg Met Val Thr Gly 
                325                 330                 335     


Leu Arg Asn Ile Pro Ser Ile Gln Ser Arg Gly Leu Phe Gly Ala Ile 
            340                 345                 350         


Ala Gly Phe Ile Glu Gly Gly Trp Thr Gly Met Ile Asp Gly Trp Tyr 
        355                 360                 365             


Gly Tyr His His Gln Asn Glu Gln Gly Ser Gly Tyr Ala Ala Asp Gln 
    370                 375                 380                 


Lys Ser Thr Gln Asn Ala Ile Asn Gly Ile Thr Asn Lys Val Asn Thr 
385                 390                 395                 400 


Val Ile Glu Lys Met Asn Ile Gln Phe Thr Ala Val Gly Lys Glu Phe 
                405                 410                 415     


Asn Lys Leu Glu Lys Arg Met Glu Asn Leu Asn Lys Lys Val Asp Asp 
            420                 425                 430         


Gly Phe Leu Asp Ile Trp Thr Tyr Asn Ala Glu Leu Leu Val Leu Leu 
        435                 440                 445             


Glu Asn Glu Arg Thr Leu Asp Phe His Asp Ser Asn Val Lys Asn Leu 
    450                 455                 460                 


Tyr Glu Lys Val Lys Ser Gln Leu Lys Asn Asn Ala Lys Glu Ile Gly 
465                 470                 475                 480 


Asn Gly Cys Phe Glu Phe Tyr His Lys Cys Asp Asn Glu Cys Met Glu 
                485                 490                 495     


Ser Val Arg Asn Gly Thr Tyr Asp Tyr Pro Lys Tyr Ser Glu Glu Ser 
            500                 505                 510         


Lys Leu Asn Arg Glu Lys Val Asp Gly Val Lys Leu Glu Ser Met Gly 
        515                 520                 525             


Ile Gly Ser Ala Gly Ser Ala Gly Tyr Ile Pro Glu Ala Pro Arg Asp 
    530                 535                 540                 


Gly Gln Ala Tyr Val Arg Lys Asp Gly Glu Trp Val Leu Leu Ser Thr 
545                 550                 555                 560 


Phe Leu 
        


<210>  54
<211>  562
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  eH1HA_d5v4

<400>  54

Met Glu Thr Pro Ala Gln Leu Leu Phe Leu Leu Leu Leu Trp Leu Pro 
1               5                   10                  15      


Asp Thr Thr Gly Asp Thr Ile Cys Ile Gly Tyr His Ala Asn Asn Ser 
            20                  25                  30          


Thr Asp Thr Val Asp Thr Val Leu Glu Lys Asn Val Thr Val Thr His 
        35                  40                  45              


Ser Val Asn Leu Leu Glu Asp Ser His Asn Gly Lys Leu Cys Lys Leu 
    50                  55                  60                  


Lys Gly Ile Ala Pro Leu Gln Leu Gly Lys Cys Asn Ile Ala Gly Trp 
65                  70                  75                  80  


Leu Leu Gly Asn Pro Gly Cys Asp Pro Leu Leu Pro Val Gly Ser Trp 
                85                  90                  95      


Ser Tyr Ile Val Glu Thr Pro Asn Ser Glu Asn Gly Ile Cys Tyr Pro 
            100                 105                 110         


Gly Asp Phe Ile Asp Tyr Glu Glu Leu Arg Glu Gln Leu Ser Ser Val 
        115                 120                 125             


Ser Ser Phe Glu Arg Phe Lys Ile Phe Pro Lys Glu Ser Ser Trp Pro 
    130                 135                 140                 


Asp His Asn Thr Asn Gly Val Thr Ala Ala Cys Ser His Glu Gly Lys 
145                 150                 155                 160 


Asn Ser Phe Tyr Arg Asn Leu Leu Trp Leu Thr Lys Lys Glu Ser Ser 
                165                 170                 175     


Tyr Pro Asn Leu Glu Asn Ser Tyr Val Asn Lys Lys Arg Lys Glu Val 
            180                 185                 190         


Leu Val Leu Trp Gly Ile His His Pro Ser Asn Ser Lys Glu Gln Gln 
        195                 200                 205             


Asn Leu Tyr Gln Asn Glu Asn Ala Tyr Val Ser Val Val Thr Ser Asn 
    210                 215                 220                 


Tyr Asn Arg Arg Phe Thr Pro Glu Ile Ala Glu Arg Pro Lys Val Lys 
225                 230                 235                 240 


Gly Gln Ala Gly Arg Met Asn Tyr Tyr Trp Thr Leu Leu Lys Pro Gly 
                245                 250                 255     


Asp Thr Ile Ile Phe Glu Ala Asn Gly Asn Leu Ile Ala Pro Met Tyr 
            260                 265                 270         


Ala Phe Ala Leu Ser Arg Gly Phe Gly Ser Gly Ile Ile Thr Ser Asn 
        275                 280                 285             


Ala Ser Met His Glu Cys Asn Thr Lys Cys Gln Thr Pro Leu Gly Ala 
    290                 295                 300                 


Ile Asn Ser Ser Leu Pro Tyr Gln Asn Ile His Pro Val Thr Ile Gly 
305                 310                 315                 320 


Glu Cys Pro Lys Tyr Val Arg Ser Ala Lys Leu Arg Met Val Thr Gly 
                325                 330                 335     


Leu Arg Asn Ile Pro Ser Ile Gln Ser Arg Gly Leu Phe Gly Ala Ile 
            340                 345                 350         


Ala Gly Phe Ile Glu Gly Gly Trp Thr Gly Met Ile Asp Gly Trp Tyr 
        355                 360                 365             


Gly Tyr His His Gln Asn Glu Gln Gly Ser Gly Tyr Ala Ala Asp Gln 
    370                 375                 380                 


Lys Ser Thr Gln Asn Ala Ile Asn Gly Ile Thr Asn Lys Val Asn Thr 
385                 390                 395                 400 


Val Ile Glu Lys Met Asn Ile Gln Phe Thr Ala Val Gly Lys Glu Phe 
                405                 410                 415     


Asn Lys Leu Glu Lys Arg Met Glu Asn Leu Asn Lys Lys Val Asp Asp 
            420                 425                 430         


Gly Phe Leu Asp Ile Trp Thr Tyr Asn Ala Glu Leu Leu Val Leu Leu 
        435                 440                 445             


Glu Asn Glu Arg Thr Leu Asp Phe His Asp Ser Asn Val Lys Asn Leu 
    450                 455                 460                 


Tyr Glu Lys Val Lys Ser Gln Leu Lys Asn Asn Ala Lys Glu Ile Gly 
465                 470                 475                 480 


Asn Gly Cys Phe Glu Phe Tyr His Lys Cys Asp Asn Glu Cys Met Glu 
                485                 490                 495     


Ser Val Arg Asn Gly Thr Tyr Asp Tyr Pro Lys Tyr Ser Glu Glu Ser 
            500                 505                 510         


Lys Leu Asn Arg Glu Lys Val Asp Gly Val Lys Leu Glu Ser Met Gly 
        515                 520                 525             


Ile Gly Ser Ala Gly Ser Ala Gly Tyr Ile Pro Glu Ala Pro Arg Asp 
    530                 535                 540                 


Gly Gln Ala Tyr Val Arg Lys Asp Gly Glu Trp Val Leu Leu Ser Thr 
545                 550                 555                 560 


Phe Leu 
        


<210>  55
<211>  233
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MRK_RBS_HA129

<400>  55

Met Lys Val Lys Leu Leu Val Leu Leu Cys Thr Phe Thr Ala Thr Tyr 
1               5                   10                  15      


Ala Gly Val Ala Pro Leu His Leu Gly Lys Cys Asn Ile Ala Gly Trp 
            20                  25                  30          


Leu Leu Gly Asn Pro Glu Cys Glu Leu Leu Leu Thr Val Ser Ser Trp 
        35                  40                  45              


Ser Tyr Ile Val Glu Thr Ser Asn Ser Asp Asn Gly Thr Cys Tyr Pro 
    50                  55                  60                  


Gly Asp Phe Ile Asn Tyr Glu Glu Leu Arg Glu Gln Leu Ser Ser Val 
65                  70                  75                  80  


Ser Ser Phe Glu Arg Phe Glu Ile Phe Pro Lys Thr Ser Ser Trp Pro 
                85                  90                  95      


Asp His Glu Thr Asn Arg Gly Val Thr Ala Ala Cys Pro Tyr Ala Gly 
            100                 105                 110         


Ala Asn Ser Phe Tyr Arg Asn Leu Ile Trp Leu Val Lys Lys Gly Asn 
        115                 120                 125             


Ser Tyr Pro Lys Leu Ser Lys Ser Tyr Val Asn Asn Lys Gly Lys Glu 
    130                 135                 140                 


Val Leu Val Leu Trp Gly Ile His His Pro Pro Thr Ser Thr Asp Gln 
145                 150                 155                 160 


Gln Ser Leu Tyr Gln Asn Ala Asp Ala Tyr Val Phe Val Gly Ser Ser 
                165                 170                 175     


Arg Tyr Ser Lys Lys Phe Lys Pro Glu Ile Ala Ile Arg Pro Lys Val 
            180                 185                 190         


Arg Asp Gln Glu Gly Arg Met Asn Tyr Tyr Trp Thr Leu Val Glu Pro 
        195                 200                 205             


Gly Asp Lys Ile Thr Phe Glu Ala Thr Gly Asn Leu Val Val Pro Arg 
    210                 215                 220                 


Tyr Ala Phe Ala Met Glu Arg Asn Ala 
225                 230             


<210>  56
<211>  233
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  RBD1-Cal09-PC-Cb

<400>  56

Met Lys Val Lys Leu Leu Val Leu Leu Cys Thr Phe Thr Ala Thr Tyr 
1               5                   10                  15      


Ala Gly Val Ala Pro Leu His Leu Gly Lys Cys Asn Ile Ala Gly Trp 
            20                  25                  30          


Ile Leu Gly Asn Pro Glu Cys Glu Ser Leu Ser Thr Ala Ser Ser Trp 
        35                  40                  45              


Ser Asn Ile Thr Glu Thr Pro Ser Ser Asp Asn Gly Thr Cys Tyr Pro 
    50                  55                  60                  


Gly Asp Phe Ile Asp Tyr Glu Glu Leu Arg Glu Gln Leu Ser Ser Val 
65                  70                  75                  80  


Ser Ser Phe Glu Arg Phe Glu Ile Phe Pro Lys Thr Ser Ser Trp Pro 
                85                  90                  95      


Asn His Ser Ser Asn Lys Gly Val Thr Ala Ala Cys Pro His Ala Gly 
            100                 105                 110         


Ala Lys Ser Phe Tyr Lys Asn Leu Ile Trp Leu Val Lys Lys Asn Gly 
        115                 120                 125             


Ser Tyr Pro Lys Leu Asn Lys Ser Tyr Ile Asn Asp Ser Gly Lys Glu 
    130                 135                 140                 


Val Leu Val Leu Trp Gly Ile His His Pro Ser Asn Ser Thr Asp Gln 
145                 150                 155                 160 


Gln Ser Leu Tyr Gln Asn Ala Asp Thr Tyr Val Phe Val Gly Ser Ser 
                165                 170                 175     


Asn Tyr Ser Lys Lys Phe Lys Pro Glu Ile Ala Ile Arg Pro Lys Val 
            180                 185                 190         


Arg Asp Gln Glu Gly Arg Met Asn Tyr Tyr Trp Thr Leu Val Glu Pro 
        195                 200                 205             


Gly Asp Lys Ile Thr Phe Glu Ala Thr Gly Asn Leu Val Val Pro Arg 
    210                 215                 220                 


Tyr Ala Phe Ala Met Glu Arg Asn Ala 
225                 230             


<210>  57
<211>  233
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  RBD1-Cal09-PC

<400>  57

Met Lys Val Lys Leu Leu Val Leu Leu Cys Thr Phe Thr Ala Thr Tyr 
1               5                   10                  15      


Ala Gly Val Ala Pro Leu His Leu Gly Lys Cys Asn Ile Ala Gly Trp 
            20                  25                  30          


Ile Leu Gly Asn Pro Glu Cys Glu Ser Asn Ser Thr Ala Ser Ser Trp 
        35                  40                  45              


Ser Asn Ile Thr Glu Thr Pro Ser Ser Asp Asn Gly Thr Cys Tyr Pro 
    50                  55                  60                  


Gly Asp Phe Ile Asp Tyr Glu Glu Leu Arg Glu Gln Leu Ser Ser Val 
65                  70                  75                  80  


Ser Ser Phe Glu Arg Phe Glu Ile Phe Pro Lys Thr Ser Ser Trp Pro 
                85                  90                  95      


Asn His Ser Ser Asn Lys Gly Val Thr Ala Ala Cys Pro His Ala Gly 
            100                 105                 110         


Ala Lys Ser Phe Tyr Lys Asn Leu Ile Trp Leu Val Lys Lys Asn Gly 
        115                 120                 125             


Ser Tyr Pro Lys Leu Asn Lys Ser Tyr Ile Asn Asp Ser Gly Lys Glu 
    130                 135                 140                 


Val Leu Val Leu Trp Gly Ile His His Pro Ser Asn Ser Thr Asp Gln 
145                 150                 155                 160 


Gln Ser Leu Tyr Gln Asn Ala Asp Thr Tyr Val Phe Val Gly Ser Ser 
                165                 170                 175     


Asn Tyr Ser Lys Lys Phe Lys Pro Glu Ile Ala Ile Arg Pro Lys Val 
            180                 185                 190         


Arg Asp Gln Glu Gly Arg Met Asn Tyr Tyr Trp Thr Leu Val Glu Pro 
        195                 200                 205             


Gly Asp Lys Ile Thr Phe Glu Ala Thr Gly Asn Leu Val Val Pro Arg 
    210                 215                 220                 


Tyr Ala Phe Ala Met Glu Arg Asn Ala 
225                 230             


<210>  58
<211>  233
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  RBD1-Cal09

<400>  58

Met Lys Val Lys Leu Leu Val Leu Leu Cys Thr Phe Thr Ala Thr Tyr 
1               5                   10                  15      


Ala Gly Val Ala Pro Leu His Leu Gly Lys Cys Asn Ile Ala Gly Trp 
            20                  25                  30          


Ile Leu Gly Asn Pro Glu Cys Glu Ser Leu Ser Thr Ala Ser Ser Trp 
        35                  40                  45              


Ser Asn Ile Thr Glu Thr Pro Ser Ser Asp Asn Gly Thr Cys Tyr Pro 
    50                  55                  60                  


Gly Asp Phe Ile Asp Tyr Glu Glu Leu Arg Glu Gln Leu Ser Ser Val 
65                  70                  75                  80  


Ser Ser Phe Glu Arg Phe Glu Ile Phe Pro Lys Thr Ser Ser Trp Pro 
                85                  90                  95      


Asn His Asp Ser Asn Lys Gly Val Thr Ala Ala Cys Pro His Ala Gly 
            100                 105                 110         


Ala Lys Ser Phe Tyr Lys Asn Leu Ile Trp Leu Val Lys Lys Gly Asn 
        115                 120                 125             


Ser Tyr Pro Lys Leu Ser Lys Ser Tyr Ile Asn Asp Lys Gly Lys Glu 
    130                 135                 140                 


Val Leu Val Leu Trp Gly Ile His His Pro Ser Thr Ser Ala Asp Gln 
145                 150                 155                 160 


Gln Ser Leu Tyr Gln Asn Ala Asp Thr Tyr Val Phe Val Gly Ser Ser 
                165                 170                 175     


Arg Tyr Ser Lys Lys Phe Lys Pro Glu Ile Ala Ile Arg Pro Lys Val 
            180                 185                 190         


Arg Asp Gln Glu Gly Arg Met Asn Tyr Tyr Trp Thr Leu Val Glu Pro 
        195                 200                 205             


Gly Asp Lys Ile Thr Phe Glu Ala Thr Gly Asn Leu Val Val Pro Arg 
    210                 215                 220                 


Tyr Ala Phe Ala Met Glu Arg Asn Ala 
225                 230             


<210>  59
<211>  233
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MRK_RBD-Cal09-PC-Cb

<400>  59

Met Lys Val Lys Leu Leu Val Leu Leu Cys Thr Phe Thr Ala Thr Tyr 
1               5                   10                  15      


Ala Gly Val Ala Pro Leu His Leu Gly Lys Cys Asn Ile Ala Gly Trp 
            20                  25                  30          


Ile Leu Gly Asn Pro Glu Cys Glu Ser Leu Ser Thr Ala Ser Ser Trp 
        35                  40                  45              


Ser Tyr Ile Val Glu Thr Pro Ser Ser Asp Asn Gly Thr Cys Tyr Pro 
    50                  55                  60                  


Gly Asp Phe Ile Asp Tyr Glu Glu Leu Arg Glu Gln Leu Ser Ser Val 
65                  70                  75                  80  


Ser Ser Phe Glu Arg Phe Glu Ile Phe Pro Lys Thr Ser Ser Trp Pro 
                85                  90                  95      


Asn His Ser Ser Asn Lys Gly Val Thr Ala Ala Cys Pro His Ala Gly 
            100                 105                 110         


Ala Lys Ser Phe Tyr Lys Asn Leu Ile Trp Leu Val Lys Lys Asn Gly 
        115                 120                 125             


Ser Tyr Pro Lys Leu Asn Lys Ser Tyr Ile Asn Asp Ser Gly Lys Glu 
    130                 135                 140                 


Val Leu Val Leu Trp Gly Ile His His Pro Ser Asn Ser Thr Asp Gln 
145                 150                 155                 160 


Gln Ser Leu Tyr Gln Asn Ala Asp Thr Tyr Val Phe Val Gly Ser Ser 
                165                 170                 175     


Asn Tyr Ser Lys Lys Phe Lys Pro Glu Ile Ala Ile Arg Pro Lys Val 
            180                 185                 190         


Arg Asp Gln Glu Gly Arg Met Asn Tyr Tyr Trp Thr Leu Val Glu Pro 
        195                 200                 205             


Gly Asp Lys Ile Thr Phe Glu Ala Thr Gly Asn Leu Val Val Pro Arg 
    210                 215                 220                 


Tyr Ala Phe Ala Met Glu Arg Asn Ala 
225                 230             


<210>  60
<211>  233
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MRK_RBD-Cal09-PC

<400>  60

Met Lys Val Lys Leu Leu Val Leu Leu Cys Thr Phe Thr Ala Thr Tyr 
1               5                   10                  15      


Ala Gly Val Ala Pro Leu His Leu Gly Lys Cys Asn Ile Ala Gly Trp 
            20                  25                  30          


Ile Leu Gly Asn Pro Glu Cys Glu Ser Asn Ser Thr Ala Ser Ser Trp 
        35                  40                  45              


Ser Tyr Ile Val Glu Thr Pro Ser Ser Asp Asn Gly Thr Cys Tyr Pro 
    50                  55                  60                  


Gly Asp Phe Ile Asp Tyr Glu Glu Leu Arg Glu Gln Leu Ser Ser Val 
65                  70                  75                  80  


Ser Ser Phe Glu Arg Phe Glu Ile Phe Pro Lys Thr Ser Ser Trp Pro 
                85                  90                  95      


Asn His Ser Ser Asn Lys Gly Val Thr Ala Ala Cys Pro His Ala Gly 
            100                 105                 110         


Ala Lys Ser Phe Tyr Lys Asn Leu Ile Trp Leu Val Lys Lys Asn Gly 
        115                 120                 125             


Ser Tyr Pro Lys Leu Asn Lys Ser Tyr Ile Asn Asp Ser Gly Lys Glu 
    130                 135                 140                 


Val Leu Val Leu Trp Gly Ile His His Pro Ser Asn Ser Thr Asp Gln 
145                 150                 155                 160 


Gln Ser Leu Tyr Gln Asn Ala Asp Thr Tyr Val Phe Val Gly Ser Ser 
                165                 170                 175     


Asn Tyr Ser Lys Lys Phe Lys Pro Glu Ile Ala Ile Arg Pro Lys Val 
            180                 185                 190         


Arg Asp Gln Glu Gly Arg Met Asn Tyr Tyr Trp Thr Leu Val Glu Pro 
        195                 200                 205             


Gly Asp Lys Ile Thr Phe Glu Ala Thr Gly Asn Leu Val Val Pro Arg 
    210                 215                 220                 


Tyr Ala Phe Ala Met Glu Arg Asn Ala 
225                 230             


<210>  61
<211>  233
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MRKRBD-Cal09

<400>  61

Met Lys Val Lys Leu Leu Val Leu Leu Cys Thr Phe Thr Ala Thr Tyr 
1               5                   10                  15      


Ala Gly Val Ala Pro Leu His Leu Gly Lys Cys Asn Ile Ala Gly Trp 
            20                  25                  30          


Ile Leu Gly Asn Pro Glu Cys Glu Ser Leu Ser Thr Ala Ser Ser Trp 
        35                  40                  45              


Ser Tyr Ile Val Glu Thr Pro Ser Ser Asp Asn Gly Thr Cys Tyr Pro 
    50                  55                  60                  


Gly Asp Phe Ile Asp Tyr Glu Glu Leu Arg Glu Gln Leu Ser Ser Val 
65                  70                  75                  80  


Ser Ser Phe Glu Arg Phe Glu Ile Phe Pro Lys Thr Ser Ser Trp Pro 
                85                  90                  95      


Asn His Asp Ser Asn Lys Gly Val Thr Ala Ala Cys Pro His Ala Gly 
            100                 105                 110         


Ala Lys Ser Phe Tyr Lys Asn Leu Ile Trp Leu Val Lys Lys Gly Asn 
        115                 120                 125             


Ser Tyr Pro Lys Leu Ser Lys Ser Tyr Ile Asn Asp Lys Gly Lys Glu 
    130                 135                 140                 


Val Leu Val Leu Trp Gly Ile His His Pro Ser Thr Ser Ala Asp Gln 
145                 150                 155                 160 


Gln Ser Leu Tyr Gln Asn Ala Asp Thr Tyr Val Phe Val Gly Ser Ser 
                165                 170                 175     


Arg Tyr Ser Lys Lys Phe Lys Pro Glu Ile Ala Ile Arg Pro Lys Val 
            180                 185                 190         


Arg Asp Gln Glu Gly Arg Met Asn Tyr Tyr Trp Thr Leu Val Glu Pro 
        195                 200                 205             


Gly Asp Lys Ile Thr Phe Glu Ala Thr Gly Asn Leu Val Val Pro Arg 
    210                 215                 220                 


Tyr Ala Phe Ala Met Glu Arg Asn Ala 
225                 230             


<210>  62
<211>  565
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FLHA_PR8

<400>  62

Met Lys Ala Asn Leu Leu Val Leu Leu Cys Ala Leu Ala Ala Ala Asp 
1               5                   10                  15      


Ala Asp Thr Ile Cys Ile Gly Tyr His Ala Asn Asn Ser Thr Asp Thr 
            20                  25                  30          


Val Asp Thr Val Leu Glu Lys Asn Val Thr Val Thr His Ser Val Asn 
        35                  40                  45              


Leu Leu Glu Asp Ser His Asn Gly Lys Leu Cys Arg Leu Lys Gly Ile 
    50                  55                  60                  


Ala Pro Leu Gln Leu Gly Lys Cys Asn Ile Ala Gly Trp Leu Leu Gly 
65                  70                  75                  80  


Asn Pro Glu Cys Asp Pro Leu Leu Pro Val Arg Ser Trp Ser Tyr Ile 
                85                  90                  95      


Val Glu Thr Pro Asn Ser Glu Asn Gly Ile Cys Tyr Pro Gly Asp Phe 
            100                 105                 110         


Ile Asp Tyr Glu Glu Leu Arg Glu Gln Leu Ser Ser Val Ser Ser Phe 
        115                 120                 125             


Glu Arg Phe Glu Ile Phe Pro Lys Glu Ser Ser Trp Pro Asn His Asn 
    130                 135                 140                 


Thr Asn Gly Val Thr Ala Ala Cys Ser His Glu Gly Lys Ser Ser Phe 
145                 150                 155                 160 


Tyr Arg Asn Leu Leu Trp Leu Thr Glu Lys Glu Gly Ser Tyr Pro Lys 
                165                 170                 175     


Leu Lys Asn Ser Tyr Val Asn Lys Lys Gly Lys Glu Val Leu Val Leu 
            180                 185                 190         


Trp Gly Ile His His Pro Pro Asn Ser Lys Glu Gln Gln Asn Leu Tyr 
        195                 200                 205             


Gln Asn Glu Asn Ala Tyr Val Ser Val Val Thr Ser Asn Tyr Asn Arg 
    210                 215                 220                 


Arg Phe Thr Pro Glu Ile Ala Glu Arg Pro Lys Val Arg Asp Gln Ala 
225                 230                 235                 240 


Gly Arg Met Asn Tyr Tyr Trp Thr Leu Leu Lys Pro Gly Asp Thr Ile 
                245                 250                 255     


Ile Phe Glu Ala Asn Gly Asn Leu Ile Ala Pro Met Tyr Ala Phe Ala 
            260                 265                 270         


Leu Ser Arg Gly Phe Gly Ser Gly Ile Ile Thr Ser Asn Ala Ser Met 
        275                 280                 285             


His Glu Cys Asn Thr Lys Cys Gln Thr Pro Leu Gly Ala Ile Asn Ser 
    290                 295                 300                 


Ser Leu Pro Tyr Gln Asn Ile His Pro Val Thr Ile Gly Glu Cys Pro 
305                 310                 315                 320 


Lys Tyr Val Arg Ser Ala Lys Leu Arg Met Val Thr Gly Leu Arg Asn 
                325                 330                 335     


Ile Pro Ser Ile Gln Ser Arg Gly Leu Phe Gly Ala Ile Ala Gly Phe 
            340                 345                 350         


Ile Glu Gly Gly Trp Thr Gly Met Ile Asp Gly Trp Tyr Gly Tyr His 
        355                 360                 365             


His Gln Asn Glu Gln Gly Ser Gly Tyr Ala Ala Asp Gln Lys Ser Thr 
    370                 375                 380                 


Gln Asn Ala Ile Asn Gly Ile Thr Asn Lys Val Asn Thr Val Ile Glu 
385                 390                 395                 400 


Lys Met Asn Ile Gln Phe Thr Ala Val Gly Lys Glu Phe Asn Lys Leu 
                405                 410                 415     


Glu Lys Arg Met Glu Asn Leu Asn Lys Lys Val Asp Asp Gly Phe Leu 
            420                 425                 430         


Asp Ile Trp Thr Tyr Asn Ala Glu Leu Leu Val Leu Leu Glu Asn Glu 
        435                 440                 445             


Arg Thr Leu Asp Phe His Asp Ser Asn Val Lys Asn Leu Tyr Glu Lys 
    450                 455                 460                 


Val Lys Ser Gln Leu Lys Asn Asn Ala Lys Glu Ile Gly Asn Gly Cys 
465                 470                 475                 480 


Phe Glu Phe Tyr His Lys Cys Asp Asn Glu Cys Met Glu Ser Val Arg 
                485                 490                 495     


Asn Gly Thr Tyr Asp Tyr Pro Lys Tyr Ser Glu Glu Ser Lys Leu Asn 
            500                 505                 510         


Arg Glu Lys Val Asp Gly Val Lys Leu Glu Ser Met Gly Ile Tyr Gln 
        515                 520                 525             


Ile Leu Ala Ile Tyr Ser Thr Val Ala Ser Ser Leu Val Leu Leu Val 
    530                 535                 540                 


Ser Leu Gly Ala Ile Ser Phe Trp Met Cys Ser Asn Gly Ser Leu Gln 
545                 550                 555                 560 


Cys Arg Ile Cys Ile 
                565 


<210>  63
<211>  566
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FLHA_Cal09

<400>  63

Met Lys Ala Ile Leu Val Val Leu Leu Tyr Thr Phe Ala Thr Ala Asn 
1               5                   10                  15      


Ala Asp Thr Leu Cys Ile Gly Tyr His Ala Asn Asn Ser Thr Asp Thr 
            20                  25                  30          


Val Asp Thr Val Leu Glu Lys Asn Val Thr Val Thr His Ser Val Asn 
        35                  40                  45              


Leu Leu Glu Asp Lys His Asn Gly Lys Leu Cys Lys Leu Arg Gly Val 
    50                  55                  60                  


Ala Pro Leu His Leu Gly Lys Cys Asn Ile Ala Gly Trp Ile Leu Gly 
65                  70                  75                  80  


Asn Pro Glu Cys Glu Ser Leu Ser Thr Ala Ser Ser Trp Ser Tyr Ile 
                85                  90                  95      


Val Glu Thr Pro Ser Ser Asp Asn Gly Thr Cys Tyr Pro Gly Asp Phe 
            100                 105                 110         


Ile Asp Tyr Glu Glu Leu Arg Glu Gln Leu Ser Ser Val Ser Ser Phe 
        115                 120                 125             


Glu Arg Phe Glu Ile Phe Pro Lys Thr Ser Ser Trp Pro Asn His Asp 
    130                 135                 140                 


Ser Asn Lys Gly Val Thr Ala Ala Cys Pro His Ala Gly Ala Lys Ser 
145                 150                 155                 160 


Phe Tyr Lys Asn Leu Ile Trp Leu Val Lys Lys Gly Asn Ser Tyr Pro 
                165                 170                 175     


Lys Leu Ser Lys Ser Tyr Ile Asn Asp Lys Gly Lys Glu Val Leu Val 
            180                 185                 190         


Leu Trp Gly Ile His His Pro Ser Thr Ser Ala Asp Gln Gln Ser Leu 
        195                 200                 205             


Tyr Gln Asn Ala Asp Thr Tyr Val Phe Val Gly Ser Ser Arg Tyr Ser 
    210                 215                 220                 


Lys Lys Phe Lys Pro Glu Ile Ala Ile Arg Pro Lys Val Arg Asp Gln 
225                 230                 235                 240 


Glu Gly Arg Met Asn Tyr Tyr Trp Thr Leu Val Glu Pro Gly Asp Lys 
                245                 250                 255     


Ile Thr Phe Glu Ala Thr Gly Asn Leu Val Val Pro Arg Tyr Ala Phe 
            260                 265                 270         


Ala Met Glu Arg Asn Ala Gly Ser Gly Ile Ile Ile Ser Asp Thr Pro 
        275                 280                 285             


Val His Asp Cys Asn Thr Thr Cys Gln Thr Pro Lys Gly Ala Ile Asn 
    290                 295                 300                 


Thr Ser Leu Pro Phe Gln Asn Ile His Pro Ile Thr Ile Gly Lys Cys 
305                 310                 315                 320 


Pro Lys Tyr Val Lys Ser Thr Lys Leu Arg Leu Ala Thr Gly Leu Arg 
                325                 330                 335     


Asn Ile Pro Ser Ile Gln Ser Arg Gly Leu Phe Gly Ala Ile Ala Gly 
            340                 345                 350         


Phe Ile Glu Gly Gly Trp Thr Gly Met Val Asp Gly Trp Tyr Gly Tyr 
        355                 360                 365             


His His Gln Asn Glu Gln Gly Ser Gly Tyr Ala Ala Asp Leu Lys Ser 
    370                 375                 380                 


Thr Gln Asn Ala Ile Asp Glu Ile Thr Asn Lys Val Asn Ser Val Ile 
385                 390                 395                 400 


Glu Lys Met Asn Thr Gln Phe Thr Ala Val Gly Lys Glu Phe Asn His 
                405                 410                 415     


Leu Glu Lys Arg Ile Glu Asn Leu Asn Lys Lys Val Asp Asp Gly Phe 
            420                 425                 430         


Leu Asp Ile Trp Thr Tyr Asn Ala Glu Leu Leu Val Leu Leu Glu Asn 
        435                 440                 445             


Glu Arg Thr Leu Asp Tyr His Asp Ser Asn Val Lys Asn Leu Tyr Glu 
    450                 455                 460                 


Lys Val Arg Ser Gln Leu Lys Asn Asn Ala Lys Glu Ile Gly Asn Gly 
465                 470                 475                 480 


Cys Phe Glu Phe Tyr His Lys Cys Asp Asn Thr Cys Met Glu Ser Val 
                485                 490                 495     


Lys Asn Gly Thr Tyr Asp Tyr Pro Lys Tyr Ser Glu Glu Ala Lys Leu 
            500                 505                 510         


Asn Arg Glu Glu Ile Asp Gly Val Lys Leu Glu Ser Thr Arg Ile Tyr 
        515                 520                 525             


Gln Ile Leu Ala Ile Tyr Ser Thr Val Ala Ser Ser Leu Val Leu Val 
    530                 535                 540                 


Val Ser Leu Gly Ala Ile Ser Phe Trp Met Cys Ser Asn Gly Ser Leu 
545                 550                 555                 560 


Gln Cys Arg Ile Cys Ile 
                565     


<210>  64
<211>  699
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  MRK_pH1_Con_RBD

<400>  64
atgaaggtga agctgctggt gctgctgtgc accttcaccg ccacctacgc cggcgtggcc       60

cctctgcacc tgggcaagtg caacatcgcc ggctggatcc tgggcaaccc tgagtgcgag      120

agccttagca cagcctcctc ctggagctac atcgtggaga cgagcagcag cgataacggg      180

acctgctacc ctggcgactt catcgactac gaggagctga gagagcagct gagcagcgtg      240

agcagcttcg agagattcga gatcttccct aagaccagca gctggcctaa ccacgacagc      300

aacaagggcg tgaccgccgc ctgcccacac gccggggcca agagcttcta caagaacctg      360

atctggctgg tgaagaaggg caacagctac cctaaactga gcaagtccta catcaacgac      420

aaaggcaagg aggtcctcgt gctctggggc atccaccacc ctagcaccag cgccgatcag      480

cagagcctgt accagaacgc cgacgcgtac gtgttcgtgg gcaccagcag atacagcaag      540

aagttcaagc ctgagatcgc catcagacct aaggtgaggg accaggaggg cagaatgaac      600

tactactgga ccctggtgga gcccggagat aagatcacat ttgaggccac cggcaacctg      660

gtggtgccta gatacgcctt cgccatggag agaaacgcc                             699


<210>  65
<211>  1680
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  MRK_pH1_Con_ecto

<400>  65
atgaaggcca tcctcgtggt gctgctgtac acctttgcca ccgccaacgc cgataccctg       60

tgtatcggct accacgccaa caacagcacc gacaccgtgg atactgtcct ggagaagaac      120

gtgaccgtga cccacagcgt gaacctgctg gaggacaagc acaacggcaa gctgtgcaag      180

ctgagaggcg tggcccctct gcacctgggc aagtgcaaca tcgccggctg gatcctgggc      240

aaccctgagt gcgagagcct tagcacagcc tcctcctgga gctacatcgt ggagacgagc      300

agcagcgata acgggacctg ctaccctggc gacttcatcg actacgagga gctgagagag      360

cagctgagca gcgtgagcag cttcgagaga ttcgagatct tccctaagac cagcagctgg      420

cctaaccacg acagcaacaa gggcgtgacc gccgcctgcc cacacgccgg ggccaagagc      480

ttctacaaga acctgatctg gctggtgaag aagggcaaca gctaccctaa actgagcaag      540

tcctacatca acgacaaagg caaggaggtc ctcgtgctct ggggcatcca ccaccctagc      600

accagcgccg atcagcagag cctgtaccag aacgccgacg cgtacgtgtt cgtgggcacc      660

agcagataca gcaagaagtt caagcctgag atcgccatca gacctaaggt gagggaccag      720

gagggcagaa tgaactacta ctggaccctg gtggagcccg gagataagat cacatttgag      780

gccaccggca acctggtggt gcctagatac gccttcgcca tggagagaaa cgccggcagc      840

ggcatcatca tcagcgacac ccctgtgcac gactgcaaca ccacctgcca gacccctaag      900

ggcgccatca acacgagcct gcctttccag aacatccacc ctatcaccat cggcaagtgc      960

cctaagtacg tgaagtcaac caaactgaga ctcgccaccg gcctcagaaa cgtgcctagc     1020

atccagagca gaggcctctt cggcgccatc gcgggattca tcgagggcgg ctggaccggc     1080

atggtggacg gctggtacgg ctaccaccat cagaacgagc agggcagcgg gtacgcggcc     1140

gacctcaaga gcacccagaa cgccatcgac aagatcacca acaaggtgaa cagcgtgatc     1200

gagaagatga acacccagtt caccgccgtg ggcaaggagt tcaaccacct ggagaagaga     1260

atcgagaacc tgaacaagaa ggtggacgac ggcttcctgg acatctggac ctacaacgca     1320

gaactgctcg tgcttctgga gaacgagaga accctggact accacgactc caacgtgaag     1380

aacctgtacg agaaggtgag aagccagctg aagaacaacg ccaaggagat cggcaacggc     1440

tgcttcgagt tctaccacaa gtgcgacaac acctgcatgg agagcgtgaa gaacggcacc     1500

tacgactacc ctaagtacag cgaggaggcc aagctgaaca gagaggagat cgacggcgtg     1560

aagctggaga gcaccagaat cggctcagcc gggagcgccg gctacatccc tgaggcccct     1620

agagacggcc aggcctacgt gagaaaggac ggcgagtggg tgctgctgag caccttcctg     1680


<210>  66
<211>  693
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  MRK_sH1_Con_RBD

<400>  66
atgaaggtga agctgctggt gctgctgtgc accttcaccg ccacctacgc cggaatcgct       60

cccctgcagc tcggcaactg cagcgtggcc ggctggattc tgggcaaccc cgagtgcgaa      120

ctgctgatta gcaaagagtc ctggagctac atcgtggaaa ccccgaatcc cgagaacggc      180

acctgctacc ccggctactt cgccgactac gaggagctaa gagagcagct gagtagcgtg      240

agctcattcg agagattcga gatctttccc aaggagtcta gctggcccaa tcacaccgtc      300

accggcgtgt ccgccagctg tagccacaac ggcaagagca gcttctacag aaacctgctg      360

tggctgaccg gcaagaacgg actgtaccct aacctgagca agagctacgc gaacaataag      420

gagaaggagg tgctagtgct gtggggcgtg caccatccgc ccaacatcgg cgaccagaga      480

gccctgtacc acaccgagaa cgcctacgtg agcgtggtga gcagccacta tagcagaaga      540

ttcacccctg agatcgccaa gaggccaaag gtgagagatc aggaaggaag aataaactac      600

tactggaccc tcctggagcc cggcgacacc atcatcttcg aggctaacgg caacctgatc      660

gcccctagat acgccttcgc cctgagcaga ggc                                   693


<210>  67
<211>  1677
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  MRK_sH1_Con_ecto

<400>  67
atgaaggtga agctgctggt gctgctgtgt accttcactg ccacttacgc cgacaccatt       60

tgcatcggct accacgccaa caacagcacc gataccgtgg acaccgtgct ggagaagaac      120

gtcaccgtga cccacagcgt gaacctgctg gaggatagcc ataacggcaa gctgtgcctg      180

ctgaagggaa tcgctcccct gcagctcggc aactgcagcg tggccggctg gattctgggc      240

aaccccgagt gcgaactgct gattagcaaa gagtcctgga gctacatcgt ggaaaccccg      300

aatcccgaga acggcacctg ctaccccggc tacttcgccg actacgagga gctaagagag      360

cagctgagta gcgtgagctc attcgagaga ttcgagatct ttcccaagga gtctagctgg      420

cccaatcaca ccgtcaccgg cgtgtccgcc agctgtagcc acaacggcaa gagcagcttc      480

tacagaaacc tgctgtggct gaccggcaag aacggactgt accctaacct gagcaagagc      540

tacgcgaaca ataaggagaa ggaggtgcta gtgctgtggg gcgtgcacca tccgcccaac      600

atcggcgacc agagagccct gtaccacacc gagaacgcct acgtgagcgt ggtgagcagc      660

cactatagca gaagattcac ccctgagatc gccaagaggc caaaggtgag agatcaggaa      720

ggaagaataa actactactg gaccctcctg gagcccggcg acaccatcat cttcgaggct      780

aacggcaacc tgatcgcccc tagatacgcc ttcgccctga gcagaggctt cggcagcggc      840

atcatcacca gcaacgctcc catggacgag tgcgacgcca agtgccagac cccgcagggc      900

gccatcaact cgagcctgcc cttccagaac gtgcaccccg tgaccatcgg cgagtgcccc      960

aagtacgtga gaagcgccaa gctgagaatg gtgaccggcc tgagaaacat cccaagcatc     1020

cagagcagag ggctgttcgg cgccatcgct ggcttcatcg agggcggctg gaccggcatg     1080

gtggacggct ggtacggtta tcaccaccag aacgagcagg gcagcggcta cgccgccgac     1140

cagaagtcca cccagaacgc catcaacggc attacaaaca aggtgaacag cgttatcgag     1200

aagatgaaca cccaattcac cgccgtgggc aaggagttca acaagctgga gagaagaatg     1260

gagaacctga acaagaaggt ggacgacggc ttcctggaca tctggaccta caacgccgaa     1320

ctgctggtcc tgctggagaa cgagagaacc ctggacttcc acgactccaa cgtgaagaac     1380

ttatacgaga aggtcaaatc ccagctgaag aacaacgcca aagaaatcgg aaacggctgc     1440

ttcgaattct accacaagtg caacgacgag tgcatggaga gcgtgaagaa cggaacctac     1500

gactacccca agtacagcga ggaaagcaaa ctgaacagag agaagatcga cggcgtgaag     1560

ttagagagca tgggcgtggg cagcgccggc tctgctggat acatccctga ggcccctaga     1620

gacggccagg cctacgtgag aaaggacggc gagtgggtgc tgctgagcac cttcctg        1677


<210>  68
<211>  1695
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  MRK_sH1_Con_v2

<400>  68
atgaaggtga aactcctcgt cctgctgtgc accttcaccg ccacctacgc cgataccatc       60

tgtattggct accacgccaa caactccacc gacaccgtgg ataccgtgct cgagaagaac      120

gtgaccgtga cccacagcgt gaacctgctg gagaacagcc acaacggcaa gctgtgcctg      180

ctgaagggca tcgcgcccct gcagttgggt aactgctccg tggccggctg gatcctgggc      240

aaccctgagt gcgagctgct gatcagcaag gagagctgga gctacatcgt ggagaagcct      300

aaccccgaga acggcacctg ctaccctggc cacttcgccg actacgagga gctgagagag      360

caactcagca gcgtgagcag cttcgagaga ttcgagatct tccctaagga gagcagctgg      420

cccaatcaca ctgtgaccgg cgtgtccgct tcttgcagcc ataacgggga aagctccttc      480

tacagaaatc tcctttggct gacggggaag aacggcctgt accctaacct gagcaagagc      540

tacgccaaca acaaggagaa ggaggtgctg gtgctgtggg gcgtgcacca ccctcctaac      600

atcggcgacc agaaggccct gtaccacacc gagaacgcct acgtcagcgt ggtgtccagc      660

cactacagca gaaagttcac ccctgagatc gccaagaggc ctaaggtgcg ggaccaggag      720

ggcagaatca actactactg gaccctgctg gagcctggcg acaccatcat cttcgaggcc      780

aacggcaacc tgatcgcccc tagatacgcc ttcgccctga gcagaggctt cggcagcggc      840

atcatcaaca gcaacgcccc tatggacaag tgcgacgcca agtgccagac tccgcagggc      900

gctatcaaca gctccctgcc tttccagaac gtgcaccctg tgaccatcgg cgagtgccct      960

aagtacgtga gaagcgccaa gctgagaatg gtgaccggcc tgagaaacat ccctagcatc     1020

cagagcagag gcctgttcgg cgccatcgcc gggtttatcg agggcggctg gaccggcatg     1080

gtggacggct ggtacggcta ccaccaccag aacgagcagg gctccggcta cgccgccgac     1140

cagaaatcca cccagaacgc catcaacggc atcaccaaca aggtgaacag cgtcatcgag     1200

aagatgaaca cccagttcac cgccgtgggc aaggagttca acaagctgga gagaagaatg     1260

gagaacctga acaagaaggt ggacgacggc ttcatcgaca tctggaccta caacgccgag     1320

cttctggtgc tcctggagaa cgagagaacc ctggacttcc acgacagcaa cgtgaagaac     1380

ctgtacgaga aggtgaagtc ccagctgaag aacaacgcca aggagatcgg caacggctgc     1440

ttcgagttct accacaagtg caacgacgag tgcatggaga gcgtgaagaa cggcacctac     1500

gattacccca agtacagcga ggagagcaag ctgaacagag agaagatcga cggcgtgaag     1560

ctggagagca tgggcgtgta ccagatcctg gccatctact ccaccgtggc cagtagcctg     1620

gtgctgctgg tgagcctggg cgcaatcagc ttctggatgt gcagcaacgg cagcctgcag     1680

tgcagaatct gcatc                                                      1695


<210>  69
<211>  699
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  MRK_RBS_HA129

<400>  69
atgaaggtca aacttctcgt gctcctgtgc accttcaccg ccacctacgc gggcgtggct       60

ccgcttcacc tgggcaagtg caacatcgcc ggttggctgc tgggtaaccc agagtgcgag      120

ctactgctga ccgtgagcag ctggagctac atcgtggaaa ccagcaacag cgacaacggc      180

acctgctacc ctggcgactt catcaactac gaggagctga gagagcagct cagcagcgtg      240

tccagcttcg agagattcga gatcttccct aagactagca gctggcccga ccacgaaaca      300

aacagaggcg tgaccgccgc ttgtccatac gccggcgcca acagcttcta cagaaacctg      360

atctggctgg tgaagaaggg caacagctac cctaagctga gcaagagcta cgtgaacaac      420

aagggcaagg aggtgcttgt gctgtggggc atccaccacc ctcctaccag caccgaccag      480

cagagcctgt accagaacgc cgacgcctac gtgttcgtgg gcagcagcag atacagcaag      540

aagttcaagc ctgagatcgc catcagacct aaggtgaggg accaggaggg cagaatgaac      600

tactactgga ctctggtgga gcccggcgac aagatcacct tcgaggccac cggcaacctg      660

gtggtgccta gatacgcctt cgccatggag agaaacgcc                             699


<210>  70
<211>  1698
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  MRK_H1_cot_all

<400>  70
atgaaggcca tcctggtcgt gctgctctac acattcgcca ccgccaacgc agacactctg       60

tgcatcggct accacgccaa caacagcacc gacaccgtgg ataccgtgct ggagaagaac      120

gtgaccgtga cccacagcgt gaacctgctg gaggacaagc acaacggcaa gctgtgcaag      180

ctgagaggcg tggcccctct gcacctgggc aagtgcaaca tcgccggctg gatcctggga      240

aaccccgagt gcgagagcct gtcaaccgcc tcgagctggt cctacatcgt ggaaaccagc      300

agcagcgata acgggacgtg ctacccgggc gacttcatca actacgagga gctgagagaa      360

cagctgagca gcgtcagtag cttcgagaga ttcgagatct tccctaagac cagcagctgg      420

cctaaccacg acagcaacaa gggcgtgacc gccgcttgcc cgcacgcagg cgccaagagc      480

ttctacaaga acctgatctg gctggtgaag aagggcaaca gctaccctaa gctgagcaag      540

agctacatca acgacaaggg gaaggaggtg ctagtcctgt ggggcatcca tcaccctagc      600

accacagccg accagcaaag cctgtaccag aacgcggacg cctacgtgtt cgtcggcacc      660

agcagataca gcaagaagtt caagcctgag atcgccatca gacctaaggt gcgagatcag      720

gagggcagaa tgaactacta ctggaccctg gtggagcccg gagacaagat tactttcgaa      780

gcgaccggca acctggtggt gcctagatac gccttcgcca tggagagaaa cgccggcagc      840

ggcatcatca tcagcgacac ccctgtgcac gactgcaaca ccacctgcca gacccctaaa      900

ggcgccatca acacaagcct gccttttcag aacatccacc ctatcaccat cggcaagtgc      960

cctaagtacg tgaagtccac caagctccgc ctggcaaccg gcctcaggaa cgtgcctagc     1020

atccagagca gaggcctgtt cggggccata gccggcttca tagagggtgg ctggaccggc     1080

atggttgacg ggtggtacgg ataccatcac cagaacgagc aaggcagcgg ctacgccgca     1140

gacctgaagt caacccagaa cgccatcgac aagatcacca acaaggtgaa cagcgtgatc     1200

gagaagatga acacccagtt caccgccgtg ggcaaggagt tcaaccacct agagaagagg     1260

atcgagaacc tgaataagaa ggtggacgac ggcttcctgg acatctggac ctacaacgcc     1320

gagctgctcg tcctcctgga gaacgagaga accctggact accacgatag caacgtgaag     1380

aacctgtacg agaaggtgag aaaccagctg aagaataacg ccaaggagat cggcaacggc     1440

tgcttcgagt tctaccacaa gtgcgacaac acctgcatgg agagcgtgaa gaacggcacc     1500

tacgactacc ctaagtacag cgaggaggcc aagctgaaca gagagaagat cgacggcgtg     1560

aagctggaga gcaccagaat ctaccagatc ctggccatct acagcaccgt ggccagcagc     1620

ctcgtgctcg tggtgagcct gggcgccatc tccttctgga tgtgcagcaa cggcagcctg     1680

cagtgcagaa tctgcatc                                                   1698


<210>  71
<211>  1698
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  MRK_H3_cot_all

<400>  71
atgaagacca tcatcgccct gagctacatc ctgtgcctgg tgttcgcgca gaaactcccc       60

ggcaacgaca atagcactgc caccctgtgt ctgggccatc acgccgtgcc taacggaacc      120

atcgtgaaga cgatcaccaa cgacagaatc gaggtgacca acgccaccga gctggtccag      180

aattcgagca tcggcgaaat ctgcgacagc cctcaccaga tcctggacgg cgagaactgc      240

accctgattg acgcactgct aggcgaccca cagtgtgacg gcttccagaa caagaagtgg      300

gacctgttcg tggagagaag caaggcctac agcaactgct acccttacga cgtgcctgac      360

tacgccagcc tgagatccct cgtggcctcc agcggcaccc tcgagttcaa taacgagagc      420

ttcaactgga ccggagtcac ccagaacggg acatccagcg cctgcatcag aagaagcaac      480

agcagcttct tcagcagact gaactggctg acccacctga acttcaagta ccctgccctg      540

aacgtgacca tgcctaacaa cgagcagttc gacaagctgt acatctgggg cgtgcaccat      600

cccggcaccg acaaggacca gatcttcctg tacgcccaga gctccggcag gatcaccgtg      660

agcaccaaga gaagccagca ggccgtgatc cctaacatcg gcagcagacc tagaatcaga      720

aacatcccta gcagaatcag catctactgg accatagtga agcccggcga catcctgctg      780

atcaactcga ccggcaacct gatcgctcct aggggctact tcaagatcag aagcggcaag      840

agcagcatca tgagaagcga cgcgcccatc gggaagtgca agtccgagtg catcacccct      900

aacggcagca tccccaacga caagcctttc cagaacgtga acagaatcac ctacggcgcc      960

tgccctagat acgtgaagca gagcacactg aagctggcca ccggcatgag gaacgtgcct     1020

gagaagcaga ccagaggcat cttcggggct attgccggct tcatcgagaa cggttgggag     1080

ggaatggtcg acgggtggta cggcttcaga caccagaaca gcgaaggcag gggacaggcc     1140

gccgacctca agtccaccca ggctgccatc gatcagatca acgggaagct gaacagactg     1200

atcggcaaga ccaacgagaa gttccaccag atcgagaagg agttcagcga ggtggagggc     1260

agaatccagg acctggagaa gtacgtggag gacacgaaga tcgacctgtg gagctacaac     1320

gcagagctgt tggtggcact ggagaaccag cacaccatcg acctgaccga cagcgagatg     1380

aacaagctgt tcgagaagac caagaagcag ttacgagaga acgccgagga catgggaaac     1440

ggctgtttta agatctacca caagtgcgac aacgcctgca tcgggagcat caggaacggg     1500

acctacgacc acgacgtgta cagagacgag gccctgaaca acagattcca gatcaagggc     1560

gtggagctga agtccggcta caaggactgg atcctgtgga tcagcttcgc catcagctgc     1620

ttcctgctgt gcgtggccct cctgggcttt ataatgtggg cctgccagaa gggcaacatc     1680

aggtgcaaca tctgcatc                                                   1698


<210>  72
<211>  1698
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  MRK_H3_ConsensusA

<400>  72
atgaagacca tcatcgccct gagctacatc ctgtgcctgg tgttcgcgca gaaactcccc       60

ggcaacgaca atagcactgc caccctgtgt ctgggccatc acgccgtgcc taacggaacc      120

ctcgtgaaga cgatcaccaa cgaccagatc gaggtgacca acgccaccga gctggtccag      180

agttcgagca ccggcagaat ctgcgacagc cctcaccgga tcctggacgg cgagaactgc      240

accctgattg acgcactgct aggcgaccca cactgtgacg gcttccagaa caaggagtgg      300

gacctgttcg tggagagaag caaggcctac agcaactgct acccttacga cgtgcctgac      360

tacgccagcc tgagatccct cgtggcctcc agcggcaccc tcgagttcaa taacgagagc      420

ttcaactgga ccggagtcgc ccagaacggg acatcctacg cctgcaagag aggaagcgtc      480

aagagcttct tcagcagact gaactggctg caccagctga agtacaagta ccctgccctg      540

aacgtgacca tgcctaacaa cgacaagttc gacaagctgt acatctgggg cgtgcaccat      600

cccagcaccg acagcgacca gacctccctg tacgtccagg catccggcag ggtcaccgtg      660

agcaccaaga gaagccagca gaccgtgatc cctaacatcg gcagcagacc ttgggtcaga      720

ggcgtctcta gcagaatcag catctactgg accatagtga agcccggcga catcctgctg      780

atcaactcga ccggcaacct gatcgctcct aggggctact tcaagatcag aagcggcaag      840

agcagcatca tgagaagcga cgcgcccatc gggaagtgca actccgagtg catcacccct      900

aacggcagca tccccaacga caagcctttc cagaacgtga acagaatcac ctacggcgcc      960

tgccctagat acgtgaagca gaacacactg aagctggcca ccggcatgag gaacgtgcct     1020

gagaagcaga ccagaggcat cttcggggct attgccggct tcatcgagaa cggttgggag     1080

ggaatggtcg acgggtggta cggcttcaga caccagaaca gcgaaggcac gggacaggcc     1140

gccgacctca agtccaccca ggctgccatc aatcagatca acgggaagct gaacagactg     1200

atcgagaaga ccaacgagaa gttccaccag atcgagaagg agttcagcga ggtggagggc     1260

agaatccagg acctggagaa gtacgtggag gacacgaaga tcgacctgtg gagctacaac     1320

gcagagctgt tggtggcact ggagaaccag cacaccatcg acctgaccga cagcgagatg     1380

aacaagctgt tcgagaggac caggaagcag ttacgagaga acgccgagga catgggaaac     1440

ggctgtttta agatctacca caagtgcgac aacgcctgca tcgggagcat caggaacggg     1500

acctacgacc acgacgtgta cagagacgag gccctgaaca acagattcca gatcaagggc     1560

gtggagctga agtccggcta caaggactgg atcctgtgga tcagcttcgc catcagctgc     1620

ttcctgctgt gcgtggtcct cctgggcttt ataatgtggg cctgccagaa gggcaacatc     1680

aggtgcaaca tctgcatc                                                   1698


<210>  73
<211>  1698
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  MRK_H3_ConsensusB

<400>  73
atgaagacca tcatcgccct gagctacatc ctgtgcctgg tgttcgcgca gaaactcccc       60

ggcaacgaca atagcactgc caccctgtgt ctgggccatc acgccgtgcc taacggaacc      120

atcgtgaaga cgatcaccaa cgaccagatc gaggtgacca acgccaccga gctggtccag      180

aattcgagca ccggcgaaat ctgcgacagc cctcaccaga tcctggacgg cgagaactgc      240

accctgattg acgcactgct aggcgaccca cagtgtgacg gcttccagaa caagaagtgg      300

gacctgttcg tggagagaag caaggcctac agcaactgct acccttacga cgtgcctgac      360

tacgccagcc tgagatccct cgtggcctcc agcggcaccc tcgagttcaa taacgagagc      420

ttcaactgga ccggagtcac ccagaacggg acatccagcg cctgcatcag aagaagcaac      480

agcagcttct tcagcagact gaactggctg acccacctga acttcaagta ccctgccctg      540

aacgtgacca tgcctaacaa cgagcagttc gacaagctgt acatctgggg cgtgcaccat      600

cccggcaccg acaaggacca gatcttcctg tacgcccaga gctccggcag gatcaccgtg      660

agcaccaaga gaagccagca ggccgtgatc cctaacatcg gcagcagacc tagaatcaga      720

aacatcccta gcagaatcag catctactgg accatagtga agcccggcga catcctgctg      780

atcaactcga ccggcaacct gatcgctcct aggggctact tcaagatcag aagcggcaag      840

agcagcatca tgagaagcga cgcgcccatc gggaagtgca actccgagtg catcacccct      900

aacggcagca tccccaacga caagcctttc cagaacgtga acagaatcac ctacggcgcc      960

tgccctagat acgtgaagca gagcacactg aagctggcca ccggcatgag gaacgtgcct     1020

gagaagcaga ccagaggcat cttcggggct attgccggct tcatcgagaa cggttgggag     1080

ggaatggtcg acgggtggta cggcttcaga caccagaaca gcgaaggcag gggacaggcc     1140

gccgacctca agtccaccca ggctgccatc gatcagatca acgggaagct gaacagactg     1200

atcggcaaga ccaacgagaa gttccaccag atcgagaagg agttcagcga ggtggagggc     1260

agaatccagg acctggagaa gtacgtggag gacacgaaga tcgacctgtg gagctacaac     1320

gcagagctgt tggtggcact ggagaaccag cacaccatcg acctgaccga cagcgagatg     1380

aacaagctgt tcgagaagac caagaagcag ttacgagaga acgccgagga catgggaaac     1440

ggctgtttta agatctacca caagtgcgac aacgcctgca tcgggagcat caggaacggg     1500

acctacgacc acgacgtgta cagagacgag gccctgaaca acagattcca gatcaagggc     1560

gtggagctga agtccggcta caaggactgg atcctgtgga tcagcttcgc catcagctgc     1620

ttcctgctgt gcgtggccct cctgggcttt ataatgtggg cctgccagaa gggcaacatc     1680

aggtgcaaca tctgcatc                                                   1698


<210>  74
<211>  1698
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  MRK_H3_consUnique

<400>  74
atgaagacca tcatcgccct gagctacatc ctgtgcctgg tgttcgcgca gaaactcccc       60

ggcaacgaca atagcactgc caccctgtgt ctgggccatc acgccgtgcc taacggaacc      120

atcgtgaaga cgatcaccaa cgaccagatc gaggtgacca acgccaccga gctggtccag      180

agttcgagca ccggcgaaat ctgcgacagc cctcaccaga tcctggacgg cgagaactgc      240

accctgattg acgcactgct aggcgaccca cagtgtgacg gcttccagaa caagaagtgg      300

gacctgttcg tggagagaag caaggcctac agcaactgct acccttacga cgtgcctgac      360

tacgccagcc tgagatccct cgtggcctcc agcggcaccc tcgagttcaa taacgagagc      420

ttcaactgga ccggagtcac ccagaacggg acatccagcg cctgcatcag aagaagcaac      480

agcagcttct tcagcagact gaactggctg acccacctga acttcaagta ccctgccctg      540

aacgtgacca tgcctaacaa cgagcagttc gacaagctgt acatctgggg cgtgcaccat      600

cccggcaccg acaaggacca gatcttcctg tacgcccagg catccggcag gatcaccgtg      660

agcaccaaga gaagccagca ggccgtgatc cctaacatcg gcagcagacc tagagtcaga      720

aacatcccta gcagaatcag catctactgg accatagtga agcccggcga catcctgctg      780

atcaactcga ccggcaacct gatcgctcct aggggctact tcaagatcag aagcggcaag      840

agcagcatca tgagaagcga cgcgcccatc gggaagtgca actccgagtg catcacccct      900

aacggcagca tccccaacga caagcctttc cagaacgtga acagaatcac ctacggcgcc      960

tgccctagat acgtgaagca gaacacactg aagctggcca ccggcatgag gaacgtgcct     1020

gagaagcaga ccagaggcat cttcggggct attgccggct tcatcgagaa cggttgggag     1080

ggaatggtcg acgggtggta cggcttcaga caccagaaca gcgaaggcag gggacaggcc     1140

gccgacctca agtccaccca ggctgccatc gatcagatca acgggaagct gaacagactg     1200

atcggcaaga ccaacgagaa gttccaccag atcgagaagg agttcagcga ggtggagggc     1260

agaatccagg acctggagaa gtacgtggag gacacgaaga tcgacctgtg gagctacaac     1320

gcagagctgt tggtggcact ggagaaccag cacaccatcg acctgaccga cagcgagatg     1380

aacaagctgt tcgagaagac caagaagcag ttacgagaga acgccgagga catgggaaac     1440

ggctgtttta agatctacca caagtgcgac aacgcctgca tcgggagcat caggaacggg     1500

acctacgacc acgacgtgta cagagacgag gccctgaaca acagattcca gatcaagggc     1560

gtggagctga agtccggcta caaggactgg atcctgtgga tcagcttcgc catcagctgc     1620

ttcctgctgt gcgtggccct cctgggcttt ataatgtggg cctgccagaa gggcaacatc     1680

aggtgcaaca tctgcatc                                                   1698


<210>  75
<211>  699
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  RBD1-Cal09-PC-Cb

<400>  75
atgaaggtga agcttctcgt gctcttatgc accttcaccg ccacctacgc cggcgtggct       60

ccgcttcacc ttggcaagtg caacatcgcc ggctggatct tgggaaaccc cgagtgcgag      120

agcttgagca ccgccagcag ctggagcaac atcacggaaa cccctagcag cgacaacggc      180

acctgctacc ccggcgactt catcgactac gaggagctgc gggagcagct gagcagcgtg      240

agcagcttcg agcggttcga gatcttcccc aagaccagct cttggcccaa ccacagcagc      300

aacaagggcg tgaccgccgc ctgccctcac gctggcgcca agagcttcta caagaacctg      360

atctggctgg tgaagaagaa cggcagctac cccaagctga acaagtctta cattaacgac      420

tcaggcaagg aggtgctggt cctgtggggc atccaccacc ccagcaacag caccgaccaa      480

cagagcctgt accagaacgc cgacacctac gtgttcgtgg gcagcagcaa ctacagcaag      540

aagttcaagc ccgagatcgc catccggccc aaggtgcggg accaggaggg ccggatgaac      600

tactactgga ccctggtgga gcctggcgac aagatcacct tcgaggccac cggcaacctg      660

gtggtgcccc ggtacgcctt cgccatggag cggaacgcc                             699


<210>  76
<211>  699
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  RBD1-Cal09-PC

<400>  76
atgaaggtga agcttctcgt gctcttatgc accttcaccg ccacctacgc cggcgtggct       60

ccgcttcacc ttggcaagtg caacatcgcc ggctggatct tgggaaaccc cgagtgcgag      120

agcaacagca ccgccagcag ctggagcaac atcacggaaa cccctagcag cgacaacggc      180

acctgctacc ccggcgactt catcgactac gaggagctgc gggagcagct gagcagcgtg      240

agcagcttcg agcggttcga gatcttcccc aagaccagct cttggcccaa ccacagcagc      300

aacaagggcg tgaccgccgc ctgccctcac gctggcgcca agagcttcta caagaacctg      360

atctggctgg tgaagaagaa cggcagctac cccaagctga acaagtctta cattaacgac      420

tcaggcaagg aggtgctggt cctgtggggc atccaccacc ccagcaacag caccgaccaa      480

cagagcctgt accagaacgc cgacacctac gtgttcgtgg gcagcagcaa ctacagcaag      540

aagttcaagc ccgagatcgc catccggccc aaggtgcggg accaggaggg ccggatgaac      600

tactactgga ccctggtgga gcctggcgac aagatcacct tcgaggccac cggcaacctg      660

gtggtgcccc ggtacgcctt cgccatggag cggaacgcc                             699


<210>  77
<211>  699
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  RBD1-Cal09

<400>  77
atgaaggtga agcttctcgt gctcttatgc accttcaccg ccacctacgc cggcgtggct       60

ccgcttcacc ttggcaagtg caacatcgcc ggctggatct tgggaaaccc cgagtgcgag      120

agcttgagca ccgccagcag ctggagcaac atcacggaaa cccctagcag cgacaacggc      180

acctgctacc ccggcgactt catcgactac gaggagctgc gggagcagct gagcagcgtg      240

agcagcttcg agcggttcga gatcttcccc aagaccagct cttggcccaa ccacgacagc      300

aacaagggcg tgaccgccgc ctgccctcac gctggcgcca agagcttcta caagaacctg      360

atctggctgg tgaagaaggg caacagctac cccaagctgt ccaagtctta cattaacgac      420

aagggcaagg aggtgctggt cctgtggggc atccaccacc ccagcaccag cgccgaccaa      480

cagagcctgt accagaacgc cgacacctac gtgttcgtgg gcagcagccg gtacagcaag      540

aagttcaagc ccgagatcgc catccggccc aaggtgcggg accaggaggg ccggatgaac      600

tactactgga ccctggtgga gcctggcgac aagatcacct tcgaggccac cggcaacctg      660

gtggtgcccc ggtacgcctt cgccatggag cggaacgcc                             699


<210>  78
<211>  699
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  MRK_RBD-Cal09-PC-Cb

<400>  78
atgaaggtga agcttctcgt gctcttatgc accttcaccg ccacctacgc cggcgtggct       60

ccgcttcacc ttggcaagtg caacatcgcc ggctggatct tgggaaaccc cgagtgcgag      120

agcttgagca ccgccagcag ctggagctac atcgtggaaa cccctagcag cgacaacggc      180

acctgctacc ccggcgactt catcgactac gaggagctgc gggagcagct gagcagcgtg      240

agcagcttcg agcggttcga gatcttcccc aagaccagct cttggcccaa ccacagcagc      300

aacaagggcg tgaccgccgc ctgccctcac gctggcgcca agagcttcta caagaacctg      360

atctggctgg tgaagaagaa cggcagctac cccaagctga acaagtctta cattaacgac      420

tcaggcaagg aggtgctggt cctgtggggc atccaccacc ccagcaacag caccgaccaa      480

cagagcctgt accagaacgc cgacacctac gtgttcgtgg gcagcagcaa ctacagcaag      540

aagttcaagc ccgagatcgc catccggccc aaggtgcggg accaggaggg ccggatgaac      600

tactactgga ccctggtgga gcctggcgac aagatcacct tcgaggccac cggcaacctg      660

gtggtgcccc ggtacgcctt cgccatggag cggaacgcc                             699


<210>  79
<211>  699
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  MRK_RBD-Cal09-PC

<400>  79
atgaaggtga agcttctcgt gctcttatgc accttcaccg ccacctacgc cggcgtggct       60

ccgcttcacc ttggcaagtg caacatcgcc ggctggatct tgggaaaccc cgagtgcgag      120

agcaacagca ccgccagcag ctggagctac atcgtggaaa cccctagcag cgacaacggc      180

acctgctacc ccggcgactt catcgactac gaggagctgc gggagcagct gagcagcgtg      240

agcagcttcg agcggttcga gatcttcccc aagaccagct cttggcccaa ccacagcagc      300

aacaagggcg tgaccgccgc ctgccctcac gctggcgcca agagcttcta caagaacctg      360

atctggctgg tgaagaagaa cggcagctac cccaagctga acaagtctta cattaacgac      420

tcaggcaagg aggtgctggt cctgtggggc atccaccacc ccagcaacag caccgaccaa      480

cagagcctgt accagaacgc cgacacctac gtgttcgtgg gcagcagcaa ctacagcaag      540

aagttcaagc ccgagatcgc catccggccc aaggtgcggg accaggaggg ccggatgaac      600

tactactgga ccctggtgga gcctggcgac aagatcacct tcgaggccac cggcaacctg      660

gtggtgcccc ggtacgcctt cgccatggag cggaacgcc                             699


<210>  80
<211>  699
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  MRKRBD-Cal09

<400>  80
atgaaggtga agcttctcgt gctcttatgc accttcaccg ccacctacgc cggcgtggct       60

ccgcttcacc ttggcaagtg caacatcgcc ggctggatct tgggaaaccc cgagtgcgag      120

agcttgagca ccgccagcag ctggagctac atcgtggaaa cccctagcag cgacaacggc      180

acctgctacc ccggcgactt catcgactac gaggagctgc gggagcagct gagcagcgtg      240

agcagcttcg agcggttcga gatcttcccc aagaccagct cttggcccaa ccacgacagc      300

aacaagggcg tgaccgccgc ctgccctcac gctggcgcca agagcttcta caagaacctg      360

atctggctgg tgaagaaggg caacagctac cccaagctgt ccaagtctta cattaacgac      420

aagggcaagg aggtgctggt cctgtggggc atccaccacc ccagcaccag cgccgaccaa      480

cagagcctgt accagaacgc cgacacctac gtgttcgtgg gcagcagccg gtacagcaag      540

aagttcaagc ccgagatcgc catccggccc aaggtgcggg accaggaggg ccggatgaac      600

tactactgga ccctggtgga gcctggcgac aagatcacct tcgaggccac cggcaacctg      660

gtggtgcccc ggtacgcctt cgccatggag cggaacgcc                             699


<210>  81
<211>  1695
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  FLHA_PR8

<400>  81
atgaaggcca atttgttggt ccttctatgt gccctagccg ccgccgacgc cgacacaatc       60

tgcatcggat atcacgcaaa caacagcacc gacaccgtgg atacggtctt ggagaagaac      120

gtgaccgtga cccattccgt gaaccttctc gaggatagcc acaatggcaa gctgtgtaga      180

ctcaagggca ttgccccgct gcagctggga aagtgcaata ttgctggctg gctgttgggc      240

aaccctgagt gtgaccctct gttaccagtg agatcttgga gctatatcgt cgaaacccct      300

aacagcgaga acggcatatg ctacccaggc gacttcatcg actacgagga actgcgcgag      360

cagctgagct ctgtgtcgag cttcgagcgg ttcgagatct tccctaagga atctagctgg      420

cctaatcata acacaaatgg cgttactgct gcctgtagcc acgagggaaa gagcagtttc      480

taccggaatc tgctgtggct gacagagaag gagggctcct accctaagct gaagaatagc      540

tatgtgaaca agaagggcaa ggaggtgctg gtgctgtggg gaatacacca cccacctaac      600

tcgaaggagc agcagaatct gtaccagaat gagaatgcct acgtgtccgt cgtgacctcc      660

aactacaacc ggcggttcac gcctgagatc gccgagaggc ctaaggtgag ggaccaggcc      720

ggacgcatga actactactg gaccctgctg aagcctggcg atacaatcat cttcgaggct      780

aatggaaacc tgatcgcgcc aatgtacgcc ttcgccctgt ccagaggatt cggcagcggc      840

atcatcacat ccaacgcctc catgcacgaa tgcaacacca agtgccagac gcctctggga      900

gctatcaata gcagcttgcc ttaccagaat atccaccctg tgaccattgg agagtgtcca      960

aagtacgtgc gcagcgcaaa gctgcggatg gtcacaggcc tgcggaatat accttctatc     1020

cagagccgag gcctgttcgg tgccattgcc ggcttcatcg agggtggctg gaccggaatg     1080

atcgacggct ggtatggata ccaccaccag aatgaacagg gcagcggcta cgccgccgat     1140

cagaagtcca cccagaacgc aatcaatggt atcacaaaca aggtgaacac tgtaatcgag     1200

aagatgaaca tccaattcac agccgtgggc aaggagttca ataagctgga gaagcggatg     1260

gagaacctca acaagaaggt ggacgacggc ttcctggata tctggaccta caacgcagag     1320

ctgctggtgt tgctggagaa cgagagaacc ctcgacttcc atgatagcaa cgttaagaac     1380

ctatacgaga aggtgaagtc acagctgaag aataacgcca aggagattgg caacggctgc     1440

ttcgaattct accacaagtg cgacaacgag tgtatggaga gcgtccggaa tggcacctac     1500

gactatccta agtatagcga ggagagcaag cttaatagag agaaggtcga tggcgtgaag     1560

ctggagtcaa tgggaatcta ccagatcctg gctatttatt caaccgtggc atcaagtctg     1620

gtgcttctgg tcagcctggg cgccatcagc ttctggatgt gctccaatgg cagcctgcaa     1680

tgccgcatct gcata                                                      1695


<210>  82
<211>  1698
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  FLHA_Cal09

<400>  82
atgaaggcta tcttggtggt gttgttgtac acattcgcca ccgccaacgc cgacaccctc       60

tgcatcggct accacgcgaa caattcaacc gacaccgttg acaccgtcct cgagaagaac      120

gtgaccgtga ctcatagcgt caacctcctc gaggacaagc ataacggcaa gctctgtaag      180

cttagaggag tggcccctct ccacctgggc aagtgtaaca ttgcaggctg gatcctgggc      240

aaccctgagt gcgagagcct gtcaaccgct agcagctgga gctacatcgt ggaaacccca      300

tccagcgata acggcacctg ctaccctggc gatttcatcg actacgagga gctgcgcgag      360

cagttgagca gcgtctccag cttcgagaga ttcgagatct tccctaagac tagcagctgg      420

cctaatcatg actccaataa gggcgtgacg gccgcctgtc ctcacgctgg agccaagtcg      480

ttctacaaga acctgatctg gctggtaaag aagggcaaca gctacccaaa gctgagcaag      540

tcctacatca acgacaaggg caaggaagtg ctggtgctgt ggggaatcca tcacccaagc      600

acctctgcgg accagcagtc tctgtatcag aacgccgaca cctatgtgtt cgtaggctcc      660

tccagatact ccaagaagtt caagccagag attgctatcc gcccaaaggt gcgggatcaa      720

gagggtcgca tgaattatta ctggaccctg gtcgagccag gcgataagat cacattcgaa      780

gccacgggaa atctggtggt gcctagatac gctttcgcca tggagagaaa cgccggcagc      840

ggcatcatca tatccgacac acctgtgcac gactgcaaca caacatgcca gacgccaaag      900

ggagccatca acacatctct tccattccag aacattcacc caatcacaat cggcaagtgt      960

ccaaagtacg tgaagtccac caagcttaga ctggccaccg gcctgcgtaa catccctagc     1020

atccagtcga gaggcctctt cggcgccatc gccggattca ttgaaggtgg ctggaccggc     1080

atggtggacg gttggtatgg ctaccaccac cagaacgagc agggcagcgg ctacgccgcg     1140

gacctgaagt ccacccagaa cgctattgac gagatcacca acaaggtgaa cagcgtgatc     1200

gagaagatga atacccagtt caccgccgtc ggcaaggagt tcaaccatct ggagaagaga     1260

atcgagaacc tcaacaagaa ggtcgacgac ggcttcctgg acatttggac ttacaacgct     1320

gagttgttgg tgcttcttga gaatgagcgg accctggact atcacgactc aaatgtgaag     1380

aacctgtacg agaaggtgag atcccagctg aagaacaatg ctaaggaaat cggcaacggc     1440

tgcttcgagt tctatcataa gtgtgacaac acctgcatgg agtctgttaa gaacggcaca     1500

tacgactacc cgaagtactc tgaggaggcc aagctgaacc gagaggagat agacggcgtt     1560

aagctagaaa gtacaaggat ctaccagatc cttgccatct actccaccgt ggcctccagc     1620

ctggtgttgg tggtgagcct gggcgccatc agcttctgga tgtgcagtaa cggaagccta     1680

cagtgccgaa tctgcatc                                                   1698


<210>  83
<211>  585
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MRK_B_consUnique

<400>  83

Met Lys Ala Ile Ile Val Leu Leu Met Val Val Thr Ser Asn Ala Asp 
1               5                   10                  15      


Arg Ile Cys Thr Gly Ile Thr Ser Ser Asn Ser Pro His Val Val Lys 
            20                  25                  30          


Thr Ala Thr Gln Gly Glu Val Asn Val Thr Gly Val Ile Pro Leu Thr 
        35                  40                  45              


Thr Thr Pro Thr Lys Ser His Phe Ala Asn Leu Lys Gly Thr Arg Thr 
    50                  55                  60                  


Arg Gly Lys Leu Cys Pro Asp Cys Leu Asn Cys Thr Asp Leu Asp Val 
65                  70                  75                  80  


Ala Leu Gly Arg Pro Met Cys Val Gly Thr Thr Pro Ser Ala Lys Ala 
                85                  90                  95      


Ser Ile Leu His Glu Val Arg Pro Val Thr Ser Gly Cys Phe Pro Ile 
            100                 105                 110         


Met His Asp Arg Thr Lys Ile Arg Gln Leu Pro Asn Leu Leu Arg Gly 
        115                 120                 125             


Tyr Glu His Ile Arg Leu Ser Thr Gln Asn Val Ile Asp Ala Glu Lys 
    130                 135                 140                 


Ala Pro Gly Gly Pro Tyr Arg Leu Gly Thr Ser Gly Ser Cys Pro Asn 
145                 150                 155                 160 


Ala Thr Ser Lys Asn Gly Phe Phe Ala Thr Met Ala Trp Ala Val Pro 
                165                 170                 175     


Lys Asn Asp Asn Asn Lys Asn Ala Thr Asn Pro Leu Thr Val Glu Val 
            180                 185                 190         


Pro Tyr Ile Cys Thr Glu Gly Glu Asp Gln Ile Thr Val Trp Gly Phe 
        195                 200                 205             


His Ser Asp Asn Lys Thr Gln Met Lys Lys Leu Tyr Gly Asp Ser Asn 
    210                 215                 220                 


Pro Gln Lys Phe Thr Ser Ser Ala Asn Gly Val Thr Thr His Tyr Val 
225                 230                 235                 240 


Ser Gln Ile Gly Gly Phe Pro Asp Gln Thr Glu Asp Gly Gly Leu Pro 
                245                 250                 255     


Gln Ser Gly Arg Ile Val Val Asp Tyr Met Val Gln Lys Pro Gly Lys 
            260                 265                 270         


Thr Gly Thr Ile Val Tyr Gln Arg Gly Val Leu Leu Pro Gln Lys Val 
        275                 280                 285             


Trp Cys Ala Ser Gly Arg Ser Lys Val Ile Lys Gly Ser Leu Pro Leu 
    290                 295                 300                 


Ile Gly Glu Ala Asp Cys Leu His Glu Lys Tyr Gly Gly Leu Asn Lys 
305                 310                 315                 320 


Ser Lys Pro Tyr Tyr Thr Gly Glu His Ala Lys Ala Ile Gly Asn Cys 
                325                 330                 335     


Pro Ile Trp Val Lys Thr Pro Leu Lys Leu Ala Asn Gly Thr Lys Tyr 
            340                 345                 350         


Arg Pro Pro Ala Lys Leu Leu Lys Glu Arg Gly Phe Phe Gly Ala Ile 
        355                 360                 365             


Ala Gly Phe Leu Glu Gly Gly Trp Glu Gly Met Ile Ala Gly Trp His 
    370                 375                 380                 


Gly Tyr Thr Ser His Gly Ala His Gly Val Ala Val Ala Ala Asp Leu 
385                 390                 395                 400 


Lys Ser Thr Gln Glu Ala Ile Asn Lys Ile Thr Lys Asn Leu Asn Ser 
                405                 410                 415     


Leu Ser Glu Leu Glu Val Lys Asn Leu Gln Arg Leu Ser Gly Ala Met 
            420                 425                 430         


Asp Glu Leu His Asn Glu Ile Leu Glu Leu Asp Glu Lys Val Asp Asp 
        435                 440                 445             


Leu Arg Ala Asp Thr Ile Ser Ser Gln Ile Glu Leu Ala Val Leu Leu 
    450                 455                 460                 


Ser Asn Glu Gly Ile Ile Asn Ser Glu Asp Glu His Leu Leu Ala Leu 
465                 470                 475                 480 


Glu Arg Lys Leu Lys Lys Met Leu Gly Pro Ser Ala Val Asp Ile Gly 
                485                 490                 495     


Asn Gly Cys Phe Glu Thr Lys His Lys Cys Asn Gln Thr Cys Leu Asp 
            500                 505                 510         


Arg Ile Ala Ala Gly Thr Phe Asn Ala Gly Glu Phe Ser Leu Pro Thr 
        515                 520                 525             


Phe Asp Ser Leu Asn Ile Thr Ala Ala Ser Leu Asn Asp Asp Gly Leu 
    530                 535                 540                 


Asp Asn His Thr Ile Leu Leu Tyr Tyr Ser Thr Ala Ala Ser Ser Leu 
545                 550                 555                 560 


Ala Val Thr Leu Met Ile Ala Ile Phe Ile Val Tyr Met Val Ser Arg 
                565                 570                 575     


Asp Asn Val Ser Cys Ser Ile Cys Leu 
            580                 585 


<210>  84
<211>  584
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MRK_B_ConsensusA

<400>  84

Met Lys Ala Ile Ile Val Leu Leu Met Val Val Thr Ser Asn Ala Asp 
1               5                   10                  15      


Arg Ile Cys Thr Gly Ile Thr Ser Ser Asn Ser Pro His Val Val Lys 
            20                  25                  30          


Thr Ala Thr Gln Gly Glu Val Asn Val Thr Gly Val Ile Pro Leu Thr 
        35                  40                  45              


Thr Thr Pro Thr Lys Ser Tyr Phe Ala Asn Leu Lys Gly Thr Arg Thr 
    50                  55                  60                  


Arg Gly Lys Leu Cys Pro Asp Cys Leu Asn Cys Thr Asp Leu Asp Val 
65                  70                  75                  80  


Ala Leu Gly Arg Pro Met Cys Val Gly Thr Thr Pro Ser Ala Lys Ala 
                85                  90                  95      


Ser Ile Leu His Glu Val Arg Pro Val Thr Ser Gly Cys Phe Pro Ile 
            100                 105                 110         


Met His Asp Arg Thr Lys Ile Arg Gln Leu Pro Asn Leu Leu Arg Gly 
        115                 120                 125             


Tyr Glu Asn Ile Arg Leu Ser Thr Gln Asn Val Ile Asp Ala Glu Lys 
    130                 135                 140                 


Ala Pro Gly Gly Pro Tyr Arg Leu Gly Thr Ser Gly Ser Cys Pro Asn 
145                 150                 155                 160 


Ala Thr Ser Lys Ile Gly Phe Phe Ala Thr Met Ala Trp Ala Val Pro 
                165                 170                 175     


Lys Asp Asn Tyr Lys Asn Ala Thr Asn Pro Leu Thr Val Glu Val Pro 
            180                 185                 190         


Tyr Ile Cys Thr Glu Gly Glu Asp Gln Ile Thr Val Trp Gly Phe His 
        195                 200                 205             


Ser Asp Asn Lys Thr Gln Met Lys Asn Leu Tyr Gly Asp Ser Asn Pro 
    210                 215                 220                 


Gln Lys Phe Thr Ser Ser Ala Asn Gly Val Thr Thr His Tyr Val Ser 
225                 230                 235                 240 


Gln Ile Gly Asp Phe Pro Asp Gln Thr Glu Asp Gly Gly Leu Pro Gln 
                245                 250                 255     


Ser Gly Arg Ile Val Val Asp Tyr Met Met Gln Lys Pro Gly Lys Thr 
            260                 265                 270         


Gly Thr Ile Val Tyr Gln Arg Gly Val Leu Leu Pro Gln Lys Val Trp 
        275                 280                 285             


Cys Ala Ser Gly Arg Ser Lys Val Ile Lys Gly Ser Leu Pro Leu Ile 
    290                 295                 300                 


Gly Glu Ala Asp Cys Leu His Glu Lys Tyr Gly Gly Leu Asn Lys Ser 
305                 310                 315                 320 


Lys Pro Tyr Tyr Thr Gly Glu His Ala Lys Ala Ile Gly Asn Cys Pro 
                325                 330                 335     


Ile Trp Val Lys Thr Pro Leu Lys Leu Ala Asn Gly Thr Lys Tyr Arg 
            340                 345                 350         


Pro Pro Ala Lys Leu Leu Lys Glu Arg Gly Phe Phe Gly Ala Ile Ala 
        355                 360                 365             


Gly Phe Leu Glu Gly Gly Trp Glu Gly Met Ile Ala Gly Trp His Gly 
    370                 375                 380                 


Tyr Thr Ser His Gly Ala His Gly Val Ala Val Ala Ala Asp Leu Lys 
385                 390                 395                 400 


Ser Thr Gln Glu Ala Ile Asn Lys Ile Thr Lys Asn Leu Asn Ser Leu 
                405                 410                 415     


Ser Glu Leu Glu Val Lys Asn Leu Gln Arg Leu Ser Gly Ala Met Asp 
            420                 425                 430         


Glu Leu His Asn Glu Ile Leu Glu Leu Asp Glu Lys Val Asp Asp Leu 
        435                 440                 445             


Arg Ala Asp Thr Ile Ser Ser Gln Ile Glu Leu Ala Val Leu Leu Ser 
    450                 455                 460                 


Asn Glu Gly Ile Ile Asn Ser Glu Asp Glu His Leu Leu Ala Leu Glu 
465                 470                 475                 480 


Arg Lys Leu Lys Lys Met Leu Gly Pro Ser Ala Val Asp Ile Gly Asn 
                485                 490                 495     


Gly Cys Phe Glu Thr Lys His Lys Cys Asn Gln Thr Cys Leu Asp Arg 
            500                 505                 510         


Ile Ala Ala Gly Thr Phe Asn Ala Gly Glu Phe Ser Leu Pro Thr Phe 
        515                 520                 525             


Asp Ser Leu Asn Ile Thr Ala Ala Ser Leu Asn Asp Asp Gly Leu Asp 
    530                 535                 540                 


Asn His Thr Ile Leu Leu Tyr Tyr Ser Thr Ala Ala Ser Ser Leu Ala 
545                 550                 555                 560 


Val Thr Leu Met Leu Ala Ile Phe Ile Val Tyr Met Val Ser Arg Asp 
                565                 570                 575     


Asn Val Ser Cys Ser Ile Cys Leu 
            580                 


<210>  85
<211>  585
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MRK_B_ConsensusB

<400>  85

Met Lys Ala Ile Ile Val Leu Leu Met Val Val Thr Ser Asn Ala Asp 
1               5                   10                  15      


Arg Ile Cys Thr Gly Ile Thr Ser Ser Asn Ser Pro His Val Val Lys 
            20                  25                  30          


Thr Ala Thr Gln Gly Glu Val Asn Val Thr Gly Val Ile Pro Leu Thr 
        35                  40                  45              


Thr Thr Pro Thr Lys Ser His Phe Ala Asn Leu Lys Gly Thr Glu Thr 
    50                  55                  60                  


Arg Gly Lys Leu Cys Pro Lys Cys Leu Asn Cys Thr Asp Leu Asp Val 
65                  70                  75                  80  


Ala Leu Gly Arg Pro Lys Cys Thr Gly Lys Ile Pro Ser Ala Arg Val 
                85                  90                  95      


Ser Ile Leu His Glu Val Arg Pro Val Thr Ser Gly Cys Phe Pro Ile 
            100                 105                 110         


Met His Asp Arg Thr Lys Ile Arg Gln Leu Pro Asn Leu Leu Arg Gly 
        115                 120                 125             


Tyr Glu His Ile Arg Leu Ser Thr His Asn Val Ile Asn Ala Glu Asn 
    130                 135                 140                 


Ala Pro Gly Gly Pro Tyr Lys Ile Gly Thr Ser Gly Ser Cys Pro Asn 
145                 150                 155                 160 


Val Thr Asn Gly Asn Gly Phe Phe Ala Thr Met Ala Trp Ala Val Pro 
                165                 170                 175     


Lys Asn Asp Lys Asn Lys Thr Ala Thr Asn Pro Leu Thr Ile Glu Val 
            180                 185                 190         


Pro Tyr Ile Cys Thr Glu Gly Glu Asp Gln Ile Thr Val Trp Gly Phe 
        195                 200                 205             


His Ser Asp Asn Glu Thr Gln Met Ala Lys Leu Tyr Gly Asp Ser Lys 
    210                 215                 220                 


Pro Gln Lys Phe Thr Ser Ser Ala Asn Gly Val Thr Thr His Tyr Val 
225                 230                 235                 240 


Ser Gln Ile Gly Gly Phe Pro Asn Gln Thr Glu Asp Gly Gly Leu Pro 
                245                 250                 255     


Gln Ser Gly Arg Ile Val Val Asp Tyr Met Val Gln Lys Ser Gly Lys 
            260                 265                 270         


Thr Gly Thr Ile Thr Tyr Gln Arg Gly Ile Leu Leu Pro Gln Lys Val 
        275                 280                 285             


Trp Cys Ala Ser Gly Arg Ser Lys Val Ile Lys Gly Ser Leu Pro Leu 
    290                 295                 300                 


Ile Gly Glu Ala Asp Cys Leu His Glu Lys Tyr Gly Gly Leu Asn Lys 
305                 310                 315                 320 


Ser Lys Pro Tyr Tyr Thr Gly Glu His Ala Lys Ala Ile Gly Asn Cys 
                325                 330                 335     


Pro Ile Trp Val Lys Thr Pro Leu Lys Leu Ala Asn Gly Thr Lys Tyr 
            340                 345                 350         


Arg Pro Pro Ala Lys Leu Leu Lys Glu Arg Gly Phe Phe Gly Ala Ile 
        355                 360                 365             


Ala Gly Phe Leu Glu Gly Gly Trp Glu Gly Met Ile Ala Gly Trp His 
    370                 375                 380                 


Gly Tyr Thr Ser His Gly Ala His Gly Val Ala Val Ala Ala Asp Leu 
385                 390                 395                 400 


Lys Ser Thr Gln Glu Ala Ile Asn Lys Ile Thr Lys Asn Leu Asn Ser 
                405                 410                 415     


Leu Ser Glu Leu Glu Val Lys Asn Leu Gln Arg Leu Ser Gly Ala Met 
            420                 425                 430         


Asp Glu Leu His Asn Glu Ile Leu Glu Leu Asp Glu Lys Val Asp Asp 
        435                 440                 445             


Leu Arg Ala Asp Thr Ile Ser Ser Gln Ile Glu Leu Ala Val Leu Leu 
    450                 455                 460                 


Ser Asn Glu Gly Ile Ile Asn Ser Glu Asp Glu His Leu Leu Ala Leu 
465                 470                 475                 480 


Glu Arg Lys Leu Lys Lys Met Leu Gly Pro Ser Ala Val Glu Ile Gly 
                485                 490                 495     


Asn Gly Cys Phe Glu Thr Lys His Lys Cys Asn Gln Thr Cys Leu Asp 
            500                 505                 510         


Arg Ile Ala Ala Gly Thr Phe Asp Ala Gly Glu Phe Ser Leu Pro Thr 
        515                 520                 525             


Phe Asp Ser Leu Asn Ile Thr Ala Ala Ser Leu Asn Asp Asp Gly Leu 
    530                 535                 540                 


Asp Asn His Thr Ile Leu Leu Tyr Tyr Ser Thr Ala Ala Ser Ser Leu 
545                 550                 555                 560 


Ala Val Thr Leu Met Ile Ala Ile Phe Val Val Tyr Met Val Ser Arg 
                565                 570                 575     


Asp Asn Val Ser Cys Ser Ile Cys Leu 
            580                 585 


<210>  86
<211>  585
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MRK_B_cot_AA

<400>  86

Met Lys Ala Ile Ile Val Leu Leu Met Val Val Thr Ser Asn Ala Asp 
1               5                   10                  15      


Arg Ile Cys Thr Gly Ile Thr Ser Ser Asn Ser Pro His Val Val Lys 
            20                  25                  30          


Thr Ala Thr Gln Gly Glu Val Asn Val Thr Gly Val Ile Pro Leu Thr 
        35                  40                  45              


Thr Thr Pro Thr Lys Ser Tyr Phe Ala Asn Leu Lys Gly Thr Arg Thr 
    50                  55                  60                  


Arg Gly Lys Leu Cys Pro Asp Cys Leu Asn Cys Thr Asp Leu Asp Val 
65                  70                  75                  80  


Ala Leu Gly Arg Pro Met Cys Val Gly Thr Thr Pro Ser Ala Lys Ala 
                85                  90                  95      


Ser Ile Leu His Glu Val Arg Pro Val Thr Ser Gly Cys Phe Pro Ile 
            100                 105                 110         


Met His Asp Arg Thr Lys Ile Arg Gln Leu Pro Asn Leu Leu Arg Gly 
        115                 120                 125             


Tyr Glu Asn Ile Arg Leu Ser Thr Gln Asn Val Ile Asp Ala Glu Lys 
    130                 135                 140                 


Ala Pro Gly Gly Pro Tyr Arg Leu Gly Thr Ser Gly Ser Cys Pro Asn 
145                 150                 155                 160 


Ala Thr Ser Lys Ser Gly Phe Phe Ala Thr Met Ala Trp Ala Val Pro 
                165                 170                 175     


Lys Asn Asp Asn Asn Lys Asn Ala Thr Asn Pro Leu Thr Val Glu Val 
            180                 185                 190         


Pro Tyr Ile Cys Thr Glu Gly Glu Asp Gln Ile Thr Val Trp Gly Phe 
        195                 200                 205             


His Ser Asp Asn Lys Thr Gln Met Lys Asn Leu Tyr Gly Asp Ser Asn 
    210                 215                 220                 


Pro Gln Lys Phe Thr Ser Ser Ala Asn Gly Val Thr Thr His Tyr Val 
225                 230                 235                 240 


Ser Gln Ile Gly Gly Phe Pro Asp Gln Thr Glu Asp Gly Gly Leu Pro 
                245                 250                 255     


Gln Ser Gly Arg Ile Val Val Asp Tyr Met Met Gln Lys Pro Gly Lys 
            260                 265                 270         


Thr Gly Thr Ile Val Tyr Gln Arg Gly Val Leu Leu Pro Gln Lys Val 
        275                 280                 285             


Trp Cys Ala Ser Gly Arg Ser Lys Val Ile Lys Gly Ser Leu Pro Leu 
    290                 295                 300                 


Ile Gly Glu Ala Asp Cys Leu His Glu Lys Tyr Gly Gly Leu Asn Lys 
305                 310                 315                 320 


Ser Lys Pro Tyr Tyr Thr Gly Glu His Ala Lys Ala Ile Gly Asn Cys 
                325                 330                 335     


Pro Ile Trp Val Lys Thr Pro Leu Lys Leu Ala Asn Gly Thr Lys Tyr 
            340                 345                 350         


Arg Pro Pro Ala Lys Leu Leu Lys Glu Arg Gly Phe Phe Gly Ala Ile 
        355                 360                 365             


Ala Gly Phe Leu Glu Gly Gly Trp Glu Gly Met Ile Ala Gly Trp His 
    370                 375                 380                 


Gly Tyr Thr Ser His Gly Ala His Gly Val Ala Val Ala Ala Asp Leu 
385                 390                 395                 400 


Lys Ser Thr Gln Glu Ala Ile Asn Lys Ile Thr Lys Asn Leu Asn Ser 
                405                 410                 415     


Leu Ser Glu Leu Glu Val Lys Asn Leu Gln Arg Leu Ser Gly Ala Met 
            420                 425                 430         


Asp Glu Leu His Asn Glu Ile Leu Glu Leu Asp Glu Lys Val Asp Asp 
        435                 440                 445             


Leu Arg Ala Asp Thr Ile Ser Ser Gln Ile Glu Leu Ala Val Leu Leu 
    450                 455                 460                 


Ser Asn Glu Gly Ile Ile Asn Ser Glu Asp Glu His Leu Leu Ala Leu 
465                 470                 475                 480 


Glu Arg Lys Leu Lys Lys Met Leu Gly Pro Ser Ala Val Asp Ile Gly 
                485                 490                 495     


Asn Gly Cys Phe Glu Thr Lys His Lys Cys Asn Gln Thr Cys Leu Asp 
            500                 505                 510         


Arg Ile Ala Ala Gly Thr Phe Asn Ala Gly Glu Phe Ser Leu Pro Thr 
        515                 520                 525             


Phe Asp Ser Leu Asn Ile Thr Ala Ala Ser Leu Asn Asp Asp Gly Leu 
    530                 535                 540                 


Asp Asn His Thr Ile Leu Leu Tyr Tyr Ser Thr Ala Ala Ser Ser Leu 
545                 550                 555                 560 


Ala Val Thr Leu Met Leu Ala Ile Phe Ile Val Tyr Met Val Ser Arg 
                565                 570                 575     


Asp Asn Val Ser Cys Ser Ile Cys Leu 
            580                 585 


<210>  87
<211>  585
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MRK_B_COT_A

<400>  87

Met Lys Ala Ile Ile Val Leu Leu Met Val Val Thr Ser Asn Ala Asp 
1               5                   10                  15      


Arg Ile Cys Thr Gly Ile Thr Ser Ser Asn Ser Pro His Val Val Lys 
            20                  25                  30          


Thr Ala Thr Gln Gly Glu Val Asn Val Thr Gly Val Ile Pro Leu Thr 
        35                  40                  45              


Thr Thr Pro Thr Lys Ser His Phe Ala Asn Leu Lys Gly Thr Glu Thr 
    50                  55                  60                  


Arg Gly Lys Leu Cys Pro Lys Cys Leu Asn Cys Thr Asp Leu Asp Val 
65                  70                  75                  80  


Ala Leu Gly Arg Pro Lys Cys Thr Gly Lys Ile Pro Ser Ala Arg Val 
                85                  90                  95      


Ser Ile Leu His Glu Val Arg Pro Val Thr Ser Gly Cys Phe Pro Ile 
            100                 105                 110         


Met His Asp Arg Thr Lys Ile Arg Gln Leu Pro Asn Leu Leu Arg Gly 
        115                 120                 125             


Tyr Glu His Ile Arg Leu Ser Thr His Asn Val Ile Asn Ala Glu Asn 
    130                 135                 140                 


Ala Pro Gly Gly Pro Tyr Lys Ile Gly Thr Ser Gly Ser Cys Pro Asn 
145                 150                 155                 160 


Val Thr Asn Gly Asn Gly Phe Phe Ala Thr Met Ala Trp Ala Val Pro 
                165                 170                 175     


Lys Asn Asp Lys Asn Lys Thr Ala Thr Asn Pro Leu Thr Ile Glu Val 
            180                 185                 190         


Pro Tyr Ile Cys Thr Glu Gly Glu Asp Gln Ile Thr Val Trp Gly Phe 
        195                 200                 205             


His Ser Asp Asn Glu Thr Gln Met Ala Lys Leu Tyr Gly Asp Ser Lys 
    210                 215                 220                 


Pro Gln Lys Phe Thr Ser Ser Ala Asn Gly Val Thr Thr His Tyr Val 
225                 230                 235                 240 


Ser Gln Ile Gly Gly Phe Pro Asn Gln Thr Glu Asp Gly Gly Leu Pro 
                245                 250                 255     


Gln Ser Gly Arg Ile Val Val Asp Tyr Met Val Gln Lys Ser Gly Lys 
            260                 265                 270         


Thr Gly Thr Ile Thr Tyr Gln Arg Gly Ile Leu Leu Pro Gln Lys Val 
        275                 280                 285             


Trp Cys Ala Ser Gly Arg Ser Lys Val Ile Lys Gly Ser Leu Pro Leu 
    290                 295                 300                 


Ile Gly Glu Ala Asp Cys Leu His Glu Lys Tyr Gly Gly Leu Asn Lys 
305                 310                 315                 320 


Ser Lys Pro Tyr Tyr Thr Gly Glu His Ala Lys Ala Ile Gly Asn Cys 
                325                 330                 335     


Pro Ile Trp Val Lys Thr Pro Leu Lys Leu Ala Asn Gly Thr Lys Tyr 
            340                 345                 350         


Arg Pro Pro Ala Lys Leu Leu Lys Glu Arg Gly Phe Phe Gly Ala Ile 
        355                 360                 365             


Ala Gly Phe Leu Glu Gly Gly Trp Glu Gly Met Ile Ala Gly Trp His 
    370                 375                 380                 


Gly Tyr Thr Ser His Gly Ala His Gly Val Ala Val Ala Ala Asp Leu 
385                 390                 395                 400 


Lys Ser Thr Gln Glu Ala Ile Asn Lys Ile Thr Lys Asn Leu Asn Ser 
                405                 410                 415     


Leu Ser Glu Leu Glu Val Lys Asn Leu Gln Arg Leu Ser Gly Ala Met 
            420                 425                 430         


Asp Glu Leu His Asn Glu Ile Leu Glu Leu Asp Glu Lys Val Asp Asp 
        435                 440                 445             


Leu Arg Ala Asp Thr Ile Ser Ser Gln Ile Glu Leu Ala Val Leu Leu 
    450                 455                 460                 


Ser Asn Glu Gly Ile Ile Asn Ser Glu Asp Glu His Leu Leu Ala Leu 
465                 470                 475                 480 


Glu Arg Lys Leu Lys Lys Met Leu Gly Pro Ser Ala Val Glu Ile Gly 
                485                 490                 495     


Asn Gly Cys Phe Glu Thr Lys His Lys Cys Asn Gln Thr Cys Leu Asp 
            500                 505                 510         


Arg Ile Ala Ala Gly Thr Phe Asp Ala Gly Glu Phe Ser Leu Pro Thr 
        515                 520                 525             


Phe Asp Ser Leu Asn Ile Thr Ala Ala Ser Leu Asn Asp Asp Gly Leu 
    530                 535                 540                 


Asp Asn His Thr Ile Leu Leu Tyr Tyr Ser Thr Ala Ala Ser Ser Leu 
545                 550                 555                 560 


Ala Val Thr Leu Met Ile Ala Ile Phe Val Val Tyr Met Val Ser Arg 
                565                 570                 575     


Asp Asn Val Ser Cys Ser Ile Cys Leu 
            580                 585 


<210>  88
<211>  584
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MRK_B_COT_B

<400>  88

Met Lys Ala Ile Ile Val Leu Leu Met Val Val Thr Ser Asn Ala Asp 
1               5                   10                  15      


Arg Ile Cys Thr Gly Ile Thr Ser Ser Asn Ser Pro His Val Val Lys 
            20                  25                  30          


Thr Ala Thr Gln Gly Glu Val Asn Val Thr Gly Val Ile Pro Leu Thr 
        35                  40                  45              


Thr Thr Pro Thr Lys Ser Tyr Phe Ala Asn Leu Lys Gly Thr Arg Thr 
    50                  55                  60                  


Arg Gly Lys Leu Cys Pro Asp Cys Leu Asn Cys Thr Asp Leu Asp Val 
65                  70                  75                  80  


Ala Leu Gly Arg Pro Met Cys Val Gly Thr Thr Pro Ser Ala Lys Ala 
                85                  90                  95      


Ser Ile Leu His Glu Val Arg Pro Val Thr Ser Gly Cys Phe Pro Ile 
            100                 105                 110         


Met His Asp Arg Thr Lys Ile Arg Gln Leu Pro Asn Leu Leu Arg Gly 
        115                 120                 125             


Tyr Glu Asn Ile Arg Leu Ser Thr Gln Asn Val Ile Asp Ala Glu Lys 
    130                 135                 140                 


Ala Pro Gly Gly Pro Tyr Arg Leu Gly Thr Ser Gly Ser Cys Pro Asn 
145                 150                 155                 160 


Ala Thr Ser Lys Ile Gly Phe Phe Ala Thr Met Ala Trp Ala Val Pro 
                165                 170                 175     


Lys Asp Asn Tyr Lys Asn Ala Thr Asn Pro Leu Thr Val Glu Val Pro 
            180                 185                 190         


Tyr Ile Cys Thr Glu Gly Glu Asp Gln Ile Thr Val Trp Gly Phe His 
        195                 200                 205             


Ser Asp Asn Lys Thr Gln Met Lys Ser Leu Tyr Gly Asp Ser Asn Pro 
    210                 215                 220                 


Gln Lys Phe Thr Ser Ser Ala Asn Gly Val Thr Thr His Tyr Val Ser 
225                 230                 235                 240 


Gln Ile Gly Asp Phe Pro Asp Gln Thr Glu Asp Gly Gly Leu Pro Gln 
                245                 250                 255     


Ser Gly Arg Ile Val Val Asp Tyr Met Met Gln Lys Pro Gly Lys Thr 
            260                 265                 270         


Gly Thr Ile Val Tyr Gln Arg Gly Val Leu Leu Pro Gln Lys Val Trp 
        275                 280                 285             


Cys Ala Ser Gly Arg Ser Lys Val Ile Lys Gly Ser Leu Pro Leu Ile 
    290                 295                 300                 


Gly Glu Ala Asp Cys Leu His Glu Lys Tyr Gly Gly Leu Asn Lys Ser 
305                 310                 315                 320 


Lys Pro Tyr Tyr Thr Gly Glu His Ala Lys Ala Ile Gly Asn Cys Pro 
                325                 330                 335     


Ile Trp Val Lys Thr Pro Leu Lys Leu Ala Asn Gly Thr Lys Tyr Arg 
            340                 345                 350         


Pro Pro Ala Lys Leu Leu Lys Glu Arg Gly Phe Phe Gly Ala Ile Ala 
        355                 360                 365             


Gly Phe Leu Glu Gly Gly Trp Glu Gly Met Ile Ala Gly Trp His Gly 
    370                 375                 380                 


Tyr Thr Ser His Gly Ala His Gly Val Ala Val Ala Ala Asp Leu Lys 
385                 390                 395                 400 


Ser Thr Gln Glu Ala Ile Asn Lys Ile Thr Lys Asn Leu Asn Ser Leu 
                405                 410                 415     


Ser Glu Leu Glu Val Lys Asn Leu Gln Arg Leu Ser Gly Ala Met Asp 
            420                 425                 430         


Glu Leu His Asn Glu Ile Leu Glu Leu Asp Glu Lys Val Asp Asp Leu 
        435                 440                 445             


Arg Ala Asp Thr Ile Ser Ser Gln Ile Glu Leu Ala Val Leu Leu Ser 
    450                 455                 460                 


Asn Glu Gly Ile Ile Asn Ser Glu Asp Glu His Leu Leu Ala Leu Glu 
465                 470                 475                 480 


Arg Lys Leu Lys Lys Met Leu Gly Pro Ser Ala Val Asp Ile Gly Asn 
                485                 490                 495     


Gly Cys Phe Glu Thr Lys His Lys Cys Asn Gln Thr Cys Leu Asp Arg 
            500                 505                 510         


Ile Ala Ala Gly Thr Phe Asn Ala Gly Glu Phe Ser Leu Pro Thr Phe 
        515                 520                 525             


Asp Ser Leu Asn Ile Thr Ala Ala Ser Leu Asn Asp Asp Gly Leu Asp 
    530                 535                 540                 


Asn His Thr Ile Leu Leu Tyr Tyr Ser Thr Ala Ala Ser Ser Leu Ala 
545                 550                 555                 560 


Val Thr Leu Met Leu Ala Ile Phe Ile Val Tyr Met Val Ser Arg Asp 
                565                 570                 575     


Asn Val Ser Cys Ser Ile Cys Leu 
            580                 


