                         SEQUENCE LISTING

<110>  Medical University of South Carolina
       Tomlinson, Stephen
       Adkins, DeAnna
       Alawieh, Ali
 
<120>  COMPOSITIONS AND METHODS FOR TREATING CENTRAL NERVOUS SYSTEM 
       INJURY

<130>  206085-0011-00-WO.606886

<150>  US 62/409,184
<151>  2016-10-17

<160>  18    

<170>  PatentIn version 3.5

<210>  1
<211>  1087
<212>  PRT
<213>  Homo sapiens

<400>  1

Met Gly Ala Ala Gly Leu Leu Gly Val Phe Leu Ala Leu Val Ala Pro 
1               5                   10                  15      


Gly Val Leu Gly Ile Ser Cys Gly Ser Pro Pro Pro Ile Leu Asn Gly 
            20                  25                  30          


Arg Ile Ser Tyr Tyr Ser Thr Pro Ile Ala Val Gly Thr Val Ile Arg 
        35                  40                  45              


Tyr Ser Cys Ser Gly Thr Phe Arg Leu Ile Gly Glu Lys Ser Leu Leu 
    50                  55                  60                  


Cys Ile Thr Lys Asp Lys Val Asp Gly Thr Trp Asp Lys Pro Ala Pro 
65                  70                  75                  80  


Lys Cys Glu Tyr Phe Asn Lys Tyr Ser Ser Cys Pro Glu Pro Ile Val 
                85                  90                  95      


Pro Gly Gly Tyr Lys Ile Arg Gly Ser Thr Pro Tyr Arg His Gly Asp 
            100                 105                 110         


Ser Val Thr Phe Ala Cys Lys Thr Asn Phe Ser Met Asn Gly Asn Lys 
        115                 120                 125             


Ser Val Trp Cys Gln Ala Asn Asn Met Trp Gly Pro Thr Arg Leu Pro 
    130                 135                 140                 


Thr Cys Val Ser Val Phe Pro Leu Glu Cys Pro Ala Leu Pro Met Ile 
145                 150                 155                 160 


His Asn Gly His His Thr Ser Glu Asn Val Gly Ser Ile Ala Pro Gly 
                165                 170                 175     


Leu Ser Val Thr Tyr Ser Cys Glu Ser Gly Tyr Leu Leu Val Gly Glu 
            180                 185                 190         


Lys Ile Ile Asn Cys Leu Ser Ser Gly Lys Trp Ser Ala Val Pro Pro 
        195                 200                 205             


Thr Cys Glu Glu Ala Arg Cys Lys Ser Leu Gly Arg Phe Pro Asn Gly 
    210                 215                 220                 


Lys Val Lys Glu Pro Pro Ile Leu Arg Val Gly Val Thr Ala Asn Phe 
225                 230                 235                 240 


Phe Cys Asp Glu Gly Tyr Arg Leu Gln Gly Pro Pro Ser Ser Arg Cys 
                245                 250                 255     


Val Ile Ala Gly Gln Gly Val Ala Trp Thr Lys Met Pro Val Cys Glu 
            260                 265                 270         


Glu Ile Phe Cys Pro Ser Pro Pro Pro Ile Leu Asn Gly Arg His Ile 
        275                 280                 285             


Gly Asn Ser Leu Ala Asn Val Ser Tyr Gly Ser Ile Val Thr Tyr Thr 
    290                 295                 300                 


Cys Asp Pro Asp Pro Glu Glu Gly Val Asn Phe Ile Leu Ile Gly Glu 
305                 310                 315                 320 


Ser Thr Leu Arg Cys Thr Val Asp Ser Gln Lys Thr Gly Thr Trp Ser 
                325                 330                 335     


Gly Pro Ala Pro Arg Cys Glu Leu Ser Thr Ser Ala Val Gln Cys Pro 
            340                 345                 350         


His Pro Gln Ile Leu Arg Gly Arg Met Val Ser Gly Gln Lys Asp Arg 
        355                 360                 365             


Tyr Thr Tyr Asn Asp Thr Val Ile Phe Ala Cys Met Phe Gly Phe Thr 
    370                 375                 380                 


Leu Lys Gly Ser Lys Gln Ile Arg Cys Asn Ala Gln Gly Thr Trp Glu 
385                 390                 395                 400 


Pro Ser Ala Pro Val Cys Glu Lys Glu Cys Gln Ala Pro Pro Asn Ile 
                405                 410                 415     


Leu Asn Gly Gln Lys Glu Asp Arg His Met Val Arg Phe Asp Pro Gly 
            420                 425                 430         


Thr Ser Ile Lys Tyr Ser Cys Asn Pro Gly Tyr Val Leu Val Gly Glu 
        435                 440                 445             


Glu Ser Ile Gln Cys Thr Ser Glu Gly Val Trp Thr Pro Pro Val Pro 
    450                 455                 460                 


Gln Cys Lys Val Ala Ala Cys Glu Ala Thr Gly Arg Gln Leu Leu Thr 
465                 470                 475                 480 


Lys Pro Gln His Gln Phe Val Arg Pro Asp Val Asn Ser Ser Cys Gly 
                485                 490                 495     


Glu Gly Tyr Lys Leu Ser Gly Ser Val Tyr Gln Glu Cys Gln Gly Thr 
            500                 505                 510         


Ile Pro Trp Phe Met Glu Ile Arg Leu Cys Lys Glu Ile Thr Cys Pro 
        515                 520                 525             


Pro Pro Pro Val Ile Tyr Asn Gly Ala His Thr Gly Ser Ser Leu Glu 
    530                 535                 540                 


Asp Phe Pro Tyr Gly Thr Thr Val Thr Tyr Thr Cys Asn Pro Gly Pro 
545                 550                 555                 560 


Glu Arg Gly Val Glu Phe Ser Leu Ile Gly Glu Ser Thr Ile Arg Cys 
                565                 570                 575     


Thr Ser Asn Asp Gln Glu Arg Gly Thr Trp Ser Gly Pro Ala Pro Leu 
            580                 585                 590         


Cys Lys Leu Ser Leu Leu Ala Val Gln Cys Ser His Val His Ile Ala 
        595                 600                 605             


Asn Gly Tyr Lys Ile Ser Gly Lys Glu Ala Pro Tyr Phe Tyr Asn Asp 
    610                 615                 620                 


Thr Val Thr Phe Lys Cys Tyr Ser Gly Phe Thr Leu Lys Gly Ser Ser 
625                 630                 635                 640 


Gln Ile Arg Cys Lys Arg Asp Asn Thr Trp Asp Pro Glu Ile Pro Val 
                645                 650                 655     


Cys Glu Lys Gly Cys Gln Pro Pro Pro Gly Leu His His Gly Arg His 
            660                 665                 670         


Thr Gly Gly Asn Thr Val Phe Phe Val Ser Gly Met Thr Val Asp Tyr 
        675                 680                 685             


Thr Cys Asp Pro Gly Tyr Leu Leu Val Gly Asn Lys Ser Ile His Cys 
    690                 695                 700                 


Met Pro Ser Gly Asn Trp Ser Pro Ser Ala Pro Arg Cys Glu Glu Thr 
705                 710                 715                 720 


Cys Gln His Val Arg Gln Ser Leu Gln Glu Leu Pro Ala Gly Ser Arg 
                725                 730                 735     


Val Glu Leu Val Asn Thr Ser Cys Gln Asp Gly Tyr Gln Leu Thr Gly 
            740                 745                 750         


His Ala Tyr Gln Met Cys Gln Asp Ala Glu Asn Gly Ile Trp Phe Lys 
        755                 760                 765             


Lys Ile Pro Leu Cys Lys Val Ile His Cys His Pro Pro Pro Val Ile 
    770                 775                 780                 


Val Asn Gly Lys His Thr Gly Met Met Ala Glu Asn Phe Leu Tyr Gly 
785                 790                 795                 800 


Asn Glu Val Ser Tyr Glu Cys Asp Gln Gly Phe Tyr Leu Leu Gly Glu 
                805                 810                 815     


Lys Asn Cys Ser Ala Glu Val Ile Leu Lys Ala Trp Ile Leu Glu Arg 
            820                 825                 830         


Ala Phe Pro Gln Cys Leu Arg Ser Leu Cys Pro Asn Pro Glu Val Lys 
        835                 840                 845             


His Gly Tyr Lys Leu Asn Lys Thr His Ser Ala Tyr Ser His Asn Asp 
    850                 855                 860                 


Ile Val Tyr Val Asp Cys Asn Pro Gly Phe Ile Met Asn Gly Ser Arg 
865                 870                 875                 880 


Val Ile Arg Cys His Thr Asp Asn Thr Trp Val Pro Gly Val Pro Thr 
                885                 890                 895     


Cys Ile Lys Lys Ala Phe Ile Gly Cys Pro Pro Pro Pro Lys Thr Pro 
            900                 905                 910         


Asn Gly Asn His Thr Gly Gly Asn Ile Ala Arg Phe Ser Pro Gly Met 
        915                 920                 925             


Ser Ile Leu Tyr Ser Cys Asp Gln Gly Tyr Leu Val Val Gly Glu Pro 
    930                 935                 940                 


Leu Leu Leu Cys Thr His Glu Gly Thr Trp Ser Gln Pro Ala Pro His 
945                 950                 955                 960 


Cys Lys Glu Val Asn Cys Ser Ser Pro Ala Asp Met Asp Gly Ile Gln 
                965                 970                 975     


Lys Gly Leu Glu Pro Arg Lys Met Tyr Gln Tyr Gly Ala Val Val Thr 
            980                 985                 990         


Leu Glu Cys Glu Asp Gly Tyr Met  Leu Glu Gly Ser Pro  Gln Ser Gln 
        995                 1000                 1005             


Cys Gln  Ser Asp His Gln Trp  Asn Pro Pro Leu Ala  Val Cys Arg 
    1010                 1015                 1020             


Ser Arg  Ser Leu Ala Pro Val  Leu Cys Gly Ile Ala  Ala Gly Leu 
    1025                 1030                 1035             


Ile Leu  Leu Thr Phe Leu Ile  Val Ile Thr Leu Tyr  Val Ile Ser 
    1040                 1045                 1050             


Lys His  Arg Glu Arg Asn Tyr  Tyr Thr Asp Thr Ser  Gln Lys Glu 
    1055                 1060                 1065             


Ala Phe  His Leu Glu Ala Arg  Glu Val Tyr Ser Val  Asp Pro Tyr 
    1070                 1075                 1080             


Asn Pro  Ala Ser 
    1085         


<210>  2
<211>  1025
<212>  PRT
<213>  Mus musculus

<400>  2

Met Leu Thr Trp Phe Leu Phe Tyr Phe Ser Glu Ile Ser Cys Asp Pro 
1               5                   10                  15      


Pro Pro Glu Val Lys Asn Ala Arg Lys Pro Tyr Tyr Ser Leu Pro Ile 
            20                  25                  30          


Val Pro Gly Thr Val Leu Arg Tyr Thr Cys Ser Pro Ser Tyr Arg Leu 
        35                  40                  45              


Ile Gly Glu Lys Ala Ile Phe Cys Ile Ser Glu Asn Gln Val His Ala 
    50                  55                  60                  


Thr Trp Asp Lys Ala Pro Pro Ile Cys Glu Ser Val Asn Lys Thr Ile 
65                  70                  75                  80  


Ser Cys Ser Asp Pro Ile Val Pro Gly Gly Phe Met Asn Lys Gly Ser 
                85                  90                  95      


Lys Ala Pro Phe Arg His Gly Asp Ser Val Thr Phe Thr Cys Lys Ala 
            100                 105                 110         


Asn Phe Thr Met Lys Gly Ser Lys Thr Val Trp Cys Gln Ala Asn Glu 
        115                 120                 125             


Met Trp Gly Pro Thr Ala Leu Pro Val Cys Glu Ser Asp Phe Pro Leu 
    130                 135                 140                 


Glu Cys Pro Ser Leu Pro Thr Ile His Asn Gly His His Thr Gly Gln 
145                 150                 155                 160 


His Val Asp Gln Phe Val Ala Gly Leu Ser Val Thr Tyr Ser Cys Glu 
                165                 170                 175     


Pro Gly Tyr Leu Leu Thr Gly Lys Lys Thr Ile Lys Cys Leu Ser Ser 
            180                 185                 190         


Gly Asp Trp Asp Gly Val Ile Pro Thr Cys Lys Glu Ala Gln Cys Glu 
        195                 200                 205             


His Pro Gly Lys Phe Pro Asn Gly Gln Val Lys Glu Pro Leu Ser Leu 
    210                 215                 220                 


Gln Val Gly Thr Thr Val Tyr Phe Ser Cys Asn Glu Gly Tyr Gln Leu 
225                 230                 235                 240 


Gln Gly Gln Pro Ser Ser Gln Cys Val Ile Val Glu Gln Lys Ala Ile 
                245                 250                 255     


Trp Thr Lys Lys Pro Val Cys Lys Glu Ile Leu Cys Pro Pro Pro Pro 
            260                 265                 270         


Pro Val Arg Asn Gly Ser His Thr Gly Ser Phe Ser Glu Asn Val Pro 
        275                 280                 285             


Tyr Gly Ser Thr Val Thr Tyr Thr Cys Asp Pro Ser Pro Glu Lys Gly 
    290                 295                 300                 


Val Ser Phe Thr Leu Ile Gly Glu Lys Thr Ile Asn Cys Thr Thr Gly 
305                 310                 315                 320 


Ser Gln Lys Thr Gly Ile Trp Ser Gly Pro Ala Pro Tyr Cys Val Leu 
                325                 330                 335     


Ser Thr Ser Ala Val Leu Cys Leu Gln Pro Lys Ile Lys Arg Gly Gln 
            340                 345                 350         


Ile Leu Ser Ile Leu Lys Asp Ser Tyr Ser Tyr Asn Asp Thr Val Ala 
        355                 360                 365             


Phe Ser Cys Glu Pro Gly Phe Thr Leu Lys Gly Asn Arg Ser Ile Arg 
    370                 375                 380                 


Cys Asn Ala His Gly Thr Trp Glu Pro Pro Val Pro Val Cys Glu Lys 
385                 390                 395                 400 


Gly Cys Gln Ala Pro Pro Lys Ile Ile Asn Gly Gln Lys Glu Asp Ser 
                405                 410                 415     


Tyr Leu Leu Asn Phe Asp Pro Gly Thr Ser Ile Arg Tyr Ser Cys Asp 
            420                 425                 430         


Pro Gly Tyr Leu Leu Val Gly Glu Asp Thr Ile His Cys Thr Pro Glu 
        435                 440                 445             


Gly Lys Trp Thr Pro Ile Thr Pro Gln Cys Thr Val Ala Glu Cys Lys 
    450                 455                 460                 


Pro Val Gly Pro His Leu Phe Lys Arg Pro Gln Asn Gln Phe Ile Arg 
465                 470                 475                 480 


Thr Ala Val Asn Ser Ser Cys Asp Glu Gly Phe Gln Leu Ser Glu Ser 
                485                 490                 495     


Ala Tyr Gln Leu Cys Gln Gly Thr Ile Pro Trp Phe Ile Glu Ile Arg 
            500                 505                 510         


Leu Cys Lys Glu Ile Thr Cys Pro Pro Pro Pro Val Ile His Asn Gly 
        515                 520                 525             


Thr His Thr Trp Ser Ser Ser Glu Asp Val Pro Tyr Gly Thr Val Val 
    530                 535                 540                 


Thr Tyr Met Cys Tyr Pro Gly Pro Glu Glu Gly Val Lys Phe Lys Leu 
545                 550                 555                 560 


Ile Gly Glu Gln Thr Ile His Cys Thr Ser Asp Ser Arg Gly Arg Gly 
                565                 570                 575     


Ser Trp Ser Ser Pro Ala Pro Leu Cys Lys Leu Ser Leu Pro Ala Val 
            580                 585                 590         


Gln Cys Thr Asp Val His Val Glu Asn Gly Val Lys Leu Thr Asp Asn 
        595                 600                 605             


Lys Ala Pro Tyr Phe Tyr Asn Asp Ser Val Met Phe Lys Cys Asp Asp 
    610                 615                 620                 


Gly Tyr Ile Leu Ser Gly Ser Ser Gln Ile Arg Cys Lys Ala Asn Asn 
625                 630                 635                 640 


Thr Trp Asp Pro Glu Lys Pro Leu Cys Lys Lys Glu Gly Cys Glu Pro 
                645                 650                 655     


Met Arg Val His Gly Leu Pro Asp Asp Ser His Ile Lys Leu Val Lys 
            660                 665                 670         


Arg Thr Cys Gln Asn Gly Tyr Gln Leu Thr Gly Tyr Thr Tyr Glu Lys 
        675                 680                 685             


Cys Gln Asn Ala Glu Asn Gly Thr Trp Phe Lys Lys Ile Glu Val Cys 
    690                 695                 700                 


Thr Val Ile Leu Cys Gln Pro Pro Pro Lys Ile Ala Asn Gly Gly His 
705                 710                 715                 720 


Thr Gly Met Met Ala Lys His Phe Leu Tyr Gly Asn Glu Val Ser Tyr 
                725                 730                 735     


Glu Cys Asp Glu Gly Phe Tyr Leu Leu Gly Glu Lys Ser Leu Gln Cys 
            740                 745                 750         


Val Asn Asp Ser Lys Gly His Gly Ser Trp Ser Gly Pro Pro Pro Gln 
        755                 760                 765             


Cys Leu Gln Ser Ser Pro Leu Thr His Cys Pro Asp Pro Glu Val Lys 
    770                 775                 780                 


His Gly Tyr Lys Leu Asn Lys Thr His Ser Ala Phe Ser His Asn Asp 
785                 790                 795                 800 


Ile Val His Phe Val Cys Asn Gln Gly Phe Ile Met Asn Gly Ser His 
                805                 810                 815     


Leu Ile Arg Cys His Thr Asn Asn Thr Trp Leu Pro Gly Val Pro Thr 
            820                 825                 830         


Cys Ile Arg Lys Ala Ser Leu Gly Cys Gln Ser Pro Ser Thr Ile Pro 
        835                 840                 845             


Asn Gly Asn His Thr Gly Gly Ser Ile Ala Arg Phe Pro Pro Gly Met 
    850                 855                 860                 


Ser Val Met Tyr Ser Cys Tyr Gln Gly Phe Leu Met Ala Gly Glu Ala 
865                 870                 875                 880 


Arg Leu Ile Cys Thr His Glu Gly Thr Trp Ser Gln Pro Pro Pro Phe 
                885                 890                 895     


Cys Lys Glu Val Asn Cys Ser Phe Pro Glu Asp Thr Asn Gly Ile Gln 
            900                 905                 910         


Lys Gly Phe Gln Pro Gly Lys Thr Tyr Arg Phe Gly Ala Thr Val Thr 
        915                 920                 925             


Leu Glu Cys Glu Asp Gly Tyr Thr Leu Glu Gly Ser Pro Gln Ser Gln 
    930                 935                 940                 


Cys Gln Asp Asp Ser Gln Trp Asn Pro Pro Leu Ala Leu Cys Lys Tyr 
945                 950                 955                 960 


Arg Arg Trp Ser Thr Ile Pro Leu Ile Cys Gly Ile Ser Val Gly Ser 
                965                 970                 975     


Ala Leu Ile Ile Leu Met Ser Val Gly Phe Cys Met Ile Leu Lys His 
            980                 985                 990         


Arg Glu Ser Asn Tyr Tyr Thr Lys  Thr Arg Pro Lys Glu  Gly Ala Leu 
        995                 1000                 1005             


His Leu  Glu Thr Arg Glu Val  Tyr Ser Ile Asp Pro  Tyr Asn Pro 
    1010                 1015                 1020             


Ala Ser  
    1025 


<210>  3
<211>  392
<212>  PRT
<213>  Homo sapiens

<400>  3

Met Glu Pro Pro Gly Arg Arg Glu Cys Pro Phe Pro Ser Trp Arg Phe 
1               5                   10                  15      


Pro Gly Leu Leu Leu Ala Ala Met Val Leu Leu Leu Tyr Ser Phe Ser 
            20                  25                  30          


Asp Ala Cys Glu Glu Pro Pro Thr Phe Glu Ala Met Glu Leu Ile Gly 
        35                  40                  45              


Lys Pro Lys Pro Tyr Tyr Glu Ile Gly Glu Arg Val Asp Tyr Lys Cys 
    50                  55                  60                  


Lys Lys Gly Tyr Phe Tyr Ile Pro Pro Leu Ala Thr His Thr Ile Cys 
65                  70                  75                  80  


Asp Arg Asn His Thr Trp Leu Pro Val Ser Asp Asp Ala Cys Tyr Arg 
                85                  90                  95      


Glu Thr Cys Pro Tyr Ile Arg Asp Pro Leu Asn Gly Gln Ala Val Pro 
            100                 105                 110         


Ala Asn Gly Thr Tyr Glu Phe Gly Tyr Gln Met His Phe Ile Cys Asn 
        115                 120                 125             


Glu Gly Tyr Tyr Leu Ile Gly Glu Glu Ile Leu Tyr Cys Glu Leu Lys 
    130                 135                 140                 


Gly Ser Val Ala Ile Trp Ser Gly Lys Pro Pro Ile Cys Glu Lys Val 
145                 150                 155                 160 


Leu Cys Thr Pro Pro Pro Lys Ile Lys Asn Gly Lys His Thr Phe Ser 
                165                 170                 175     


Glu Val Glu Val Phe Glu Tyr Leu Asp Ala Val Thr Tyr Ser Cys Asp 
            180                 185                 190         


Pro Ala Pro Gly Pro Asp Pro Phe Ser Leu Ile Gly Glu Ser Thr Ile 
        195                 200                 205             


Tyr Cys Gly Asp Asn Ser Val Trp Ser Arg Ala Ala Pro Glu Cys Lys 
    210                 215                 220                 


Val Val Lys Cys Arg Phe Pro Val Val Glu Asn Gly Lys Gln Ile Ser 
225                 230                 235                 240 


Gly Phe Gly Lys Lys Phe Tyr Tyr Lys Ala Thr Val Met Phe Glu Cys 
                245                 250                 255     


Asp Lys Gly Phe Tyr Leu Asp Gly Ser Asp Thr Ile Val Cys Asp Ser 
            260                 265                 270         


Asn Ser Thr Trp Asp Pro Pro Val Pro Lys Cys Leu Lys Val Leu Pro 
        275                 280                 285             


Pro Ser Ser Thr Lys Pro Pro Ala Leu Ser His Ser Val Ser Thr Ser 
    290                 295                 300                 


Ser Thr Thr Lys Ser Pro Ala Ser Ser Ala Ser Gly Pro Arg Pro Thr 
305                 310                 315                 320 


Tyr Lys Pro Pro Val Ser Asn Tyr Pro Gly Tyr Pro Lys Pro Glu Glu 
                325                 330                 335     


Gly Ile Leu Asp Ser Leu Asp Val Trp Val Ile Ala Val Ile Val Ile 
            340                 345                 350         


Ala Ile Val Val Gly Val Ala Val Ile Cys Val Val Pro Tyr Arg Tyr 
        355                 360                 365             


Leu Gln Arg Arg Lys Lys Lys Gly Thr Tyr Leu Thr Asp Glu Thr His 
    370                 375                 380                 


Arg Glu Val Lys Phe Thr Ser Leu 
385                 390         


<210>  4
<211>  381
<212>  PRT
<213>  Homo sapiens

<400>  4

Met Thr Val Ala Arg Pro Ser Val Pro Ala Ala Leu Pro Leu Leu Gly 
1               5                   10                  15      


Glu Leu Pro Arg Leu Leu Leu Leu Val Leu Leu Cys Leu Pro Ala Val 
            20                  25                  30          


Trp Gly Asp Cys Gly Leu Pro Pro Asp Val Pro Asn Ala Gln Pro Ala 
        35                  40                  45              


Leu Glu Gly Arg Thr Ser Phe Pro Glu Asp Thr Val Ile Thr Tyr Lys 
    50                  55                  60                  


Cys Glu Glu Ser Phe Val Lys Ile Pro Gly Glu Lys Asp Ser Val Ile 
65                  70                  75                  80  


Cys Leu Lys Gly Ser Gln Trp Ser Asp Ile Glu Glu Phe Cys Asn Arg 
                85                  90                  95      


Ser Cys Glu Val Pro Thr Arg Leu Asn Ser Ala Ser Leu Lys Gln Pro 
            100                 105                 110         


Tyr Ile Thr Gln Asn Tyr Phe Pro Val Gly Thr Val Val Glu Tyr Glu 
        115                 120                 125             


Cys Arg Pro Gly Tyr Arg Arg Glu Pro Ser Leu Ser Pro Lys Leu Thr 
    130                 135                 140                 


Cys Leu Gln Asn Leu Lys Trp Ser Thr Ala Val Glu Phe Cys Lys Lys 
145                 150                 155                 160 


Lys Ser Cys Pro Asn Pro Gly Glu Ile Arg Asn Gly Gln Ile Asp Val 
                165                 170                 175     


Pro Gly Gly Ile Leu Phe Gly Ala Thr Ile Ser Phe Ser Cys Asn Thr 
            180                 185                 190         


Gly Tyr Lys Leu Phe Gly Ser Thr Ser Ser Phe Cys Leu Ile Ser Gly 
        195                 200                 205             


Ser Ser Val Gln Trp Ser Asp Pro Leu Pro Glu Cys Arg Glu Ile Tyr 
    210                 215                 220                 


Cys Pro Ala Pro Pro Gln Ile Asp Asn Gly Ile Ile Gln Gly Glu Arg 
225                 230                 235                 240 


Asp His Tyr Gly Tyr Arg Gln Ser Val Thr Tyr Ala Cys Asn Lys Gly 
                245                 250                 255     


Phe Thr Met Ile Gly Glu His Ser Ile Tyr Cys Thr Val Asn Asn Asp 
            260                 265                 270         


Glu Gly Glu Trp Ser Gly Pro Pro Pro Glu Cys Arg Gly Lys Ser Leu 
        275                 280                 285             


Thr Ser Lys Val Pro Pro Thr Val Gln Lys Pro Thr Thr Val Asn Val 
    290                 295                 300                 


Pro Thr Thr Glu Val Ser Pro Thr Ser Gln Lys Thr Thr Thr Lys Thr 
305                 310                 315                 320 


Thr Thr Pro Asn Ala Gln Ala Thr Arg Ser Thr Pro Val Ser Arg Thr 
                325                 330                 335     


Thr Lys His Phe His Glu Thr Thr Pro Asn Lys Gly Ser Gly Thr Thr 
            340                 345                 350         


Ser Gly Thr Thr Arg Leu Leu Ser Gly His Thr Cys Phe Thr Leu Thr 
        355                 360                 365             


Gly Leu Leu Gly Thr Leu Val Thr Met Gly Leu Leu Thr 
    370                 375                 380     


<210>  5
<211>  390
<212>  PRT
<213>  Mus musculus

<400>  5

Met Ile Arg Gly Arg Ala Pro Arg Thr Arg Pro Ser Pro Pro Pro Pro 
1               5                   10                  15      


Leu Leu Pro Leu Leu Ser Leu Ser Leu Leu Leu Leu Ser Pro Thr Val 
            20                  25                  30          


Arg Gly Asp Cys Gly Pro Pro Pro Asp Ile Pro Asn Ala Arg Pro Ile 
        35                  40                  45              


Leu Gly Arg His Ser Lys Phe Ala Glu Gln Ser Lys Val Ala Tyr Ser 
    50                  55                  60                  


Cys Asn Asn Gly Phe Lys Gln Val Pro Asp Lys Ser Asn Ile Val Val 
65                  70                  75                  80  


Cys Leu Glu Asn Gly Gln Trp Ser Ser His Glu Thr Phe Cys Glu Lys 
                85                  90                  95      


Ser Cys Val Ala Pro Glu Arg Leu Ser Phe Ala Ser Leu Lys Lys Glu 
            100                 105                 110         


Tyr Leu Asn Met Asn Phe Phe Pro Val Gly Thr Ile Val Glu Tyr Glu 
        115                 120                 125             


Cys Arg Pro Gly Phe Arg Lys Gln Pro Pro Leu Pro Gly Lys Ala Thr 
    130                 135                 140                 


Cys Leu Glu Asp Leu Val Trp Ser Pro Val Ala Gln Phe Cys Lys Lys 
145                 150                 155                 160 


Lys Ser Cys Pro Asn Pro Lys Asp Leu Asp Asn Gly His Ile Asn Ile 
                165                 170                 175     


Pro Thr Gly Ile Leu Phe Gly Ser Glu Ile Asn Phe Ser Cys Asn Pro 
            180                 185                 190         


Gly Tyr Arg Leu Val Gly Val Ser Ser Thr Phe Cys Ser Val Thr Gly 
        195                 200                 205             


Asn Thr Val Asp Trp Asp Asp Glu Phe Pro Val Cys Thr Glu Ile His 
    210                 215                 220                 


Cys Pro Glu Pro Pro Lys Ile Asn Asn Gly Ile Met Arg Gly Glu Ser 
225                 230                 235                 240 


Asp Ser Tyr Thr Tyr Ser Gln Val Val Thr Tyr Ser Cys Asp Lys Gly 
                245                 250                 255     


Phe Ile Leu Val Gly Asn Ala Ser Ile Tyr Cys Thr Val Ser Lys Ser 
            260                 265                 270         


Asp Val Gly Gln Trp Ser Ser Pro Pro Pro Arg Cys Ile Glu Lys Ser 
        275                 280                 285             


Lys Val Pro Thr Lys Lys Pro Thr Ile Asn Val Pro Ser Thr Gly Thr 
    290                 295                 300                 


Pro Ser Thr Pro Gln Lys Pro Thr Thr Glu Ser Val Pro Asn Pro Gly 
305                 310                 315                 320 


Asp Gln Pro Thr Pro Gln Lys Pro Ser Thr Val Lys Val Ser Ala Thr 
                325                 330                 335     


Gln His Val Pro Val Thr Lys Thr Thr Val Arg His Pro Ile Arg Thr 
            340                 345                 350         


Ser Thr Asp Lys Gly Glu Pro Asn Thr Gly Gly Asp Arg Tyr Ile Tyr 
        355                 360                 365             


Gly His Thr Cys Leu Ile Thr Leu Thr Val Leu His Val Met Leu Ser 
    370                 375                 380                 


Leu Ile Gly Tyr Leu Thr 
385                 390 


<210>  6
<211>  128
<212>  PRT
<213>  Homo sapiens

<400>  6

Met Gly Ile Gln Gly Gly Ser Val Leu Phe Gly Leu Leu Leu Val Leu 
1               5                   10                  15      


Ala Val Phe Cys His Ser Gly His Ser Leu Gln Cys Tyr Asn Cys Pro 
            20                  25                  30          


Asn Pro Thr Ala Asp Cys Lys Thr Ala Val Asn Cys Ser Ser Asp Phe 
        35                  40                  45              


Asp Ala Cys Leu Ile Thr Lys Ala Gly Leu Gln Val Tyr Asn Lys Cys 
    50                  55                  60                  


Trp Lys Phe Glu His Cys Asn Phe Asn Asp Val Thr Thr Arg Leu Arg 
65                  70                  75                  80  


Glu Asn Glu Leu Thr Tyr Tyr Cys Cys Lys Lys Asp Leu Cys Asn Phe 
                85                  90                  95      


Asn Glu Gln Leu Glu Asn Gly Gly Thr Ser Leu Ser Glu Lys Thr Val 
            100                 105                 110         


Leu Leu Leu Val Thr Pro Phe Leu Ala Ala Ala Trp Ser Leu His Pro 
        115                 120                 125             


<210>  7
<211>  123
<212>  PRT
<213>  Mus musculus

<400>  7

Met Arg Ala Gln Arg Gly Leu Ile Leu Leu Leu Leu Leu Leu Ala Val 
1               5                   10                  15      


Phe Cys Ser Thr Ala Val Ser Leu Thr Cys Tyr His Cys Phe Gln Pro 
            20                  25                  30          


Val Val Ser Ser Cys Asn Met Asn Ser Thr Cys Ser Pro Asp Gln Asp 
        35                  40                  45              


Ser Cys Leu Tyr Ala Val Ala Gly Met Gln Val Tyr Gln Arg Cys Trp 
    50                  55                  60                  


Lys Gln Ser Asp Cys His Gly Glu Ile Ile Met Asp Gln Leu Glu Glu 
65                  70                  75                  80  


Thr Lys Leu Lys Phe Arg Cys Cys Gln Phe Asn Leu Cys Asn Lys Ser 
                85                  90                  95      


Asp Gly Ser Leu Gly Lys Thr Pro Leu Leu Gly Thr Ser Val Leu Val 
            100                 105                 110         


Ala Ile Leu Asn Leu Cys Phe Leu Ser His Leu 
        115                 120             


<210>  8
<211>  129
<212>  PRT
<213>  Mus musculus

<400>  8

Met Arg Ala Gln Arg Gly Leu Ile Leu Leu Leu Leu Leu Leu Ala Val 
1               5                   10                  15      


Phe Cys Ser Thr Ala Val Ser Leu Lys Cys Tyr Asn Cys Phe Gln Phe 
            20                  25                  30          


Val Ser Ser Cys Lys Ile Asn Thr Thr Cys Ser Pro Asn Leu Asp Ser 
        35                  40                  45              


Cys Leu Tyr Ala Val Ala Gly Arg Gln Val Tyr Gln Gln Cys Trp Lys 
    50                  55                  60                  


Leu Ser Asp Cys Asn Ser Asn Tyr Ile Met Ser Arg Leu Asp Val Ala 
65                  70                  75                  80  


Gly Ile Gln Ser Lys Cys Cys Gln Trp Gly Leu Cys Asn Lys Asn Leu 
                85                  90                  95      


Asp Gly Leu Glu Glu Pro Asn Asn Ala Glu Thr Ser Ser Leu Arg Lys 
            100                 105                 110         


Thr Ala Leu Leu Gly Thr Ser Val Leu Val Ala Ile Leu Lys Phe Cys 
        115                 120                 125             


Phe 
    


<210>  9
<211>  483
<212>  PRT
<213>  Mus musculus

<400>  9

Met Glu Val Ser Ser Arg Ser Ser Glu Pro Leu Asp Pro Val Trp Leu 
1               5                   10                  15      


Leu Val Ala Phe Gly Arg Gly Gly Val Lys Leu Glu Val Leu Leu Leu 
            20                  25                  30          


Phe Leu Leu Pro Phe Thr Leu Gly Glu Leu Arg Gly Gly Leu Gly Lys 
        35                  40                  45              


His Gly His Thr Val His Arg Glu Pro Ala Val Asn Arg Leu Cys Ala 
    50                  55                  60                  


Asp Ser Lys Arg Trp Ser Gly Leu Pro Val Ser Ala Gln Arg Pro Phe 
65                  70                  75                  80  


Pro Met Gly His Cys Pro Ala Pro Ser Gln Leu Pro Ser Ala Lys Pro 
                85                  90                  95      


Ile Asn Leu Thr Asp Glu Ser Met Phe Pro Ile Gly Thr Tyr Leu Leu 
            100                 105                 110         


Tyr Glu Cys Leu Pro Gly Tyr Ile Lys Arg Gln Phe Ser Ile Thr Cys 
        115                 120                 125             


Lys Gln Asp Ser Thr Trp Thr Ser Ala Glu Asp Lys Cys Ile Arg Lys 
    130                 135                 140                 


Gln Cys Lys Thr Pro Ser Asp Pro Glu Asn Gly Leu Val His Val His 
145                 150                 155                 160 


Thr Gly Ile Gln Phe Gly Ser Arg Ile Asn Tyr Thr Cys Asn Gln Gly 
                165                 170                 175     


Tyr Arg Leu Ile Gly Ser Ser Ser Ala Val Cys Val Ile Thr Asp Gln 
            180                 185                 190         


Ser Val Asp Trp Asp Thr Glu Ala Pro Ile Cys Glu Trp Ile Pro Cys 
        195                 200                 205             


Glu Ile Pro Pro Gly Ile Pro Asn Gly Asp Phe Phe Ser Ser Thr Arg 
    210                 215                 220                 


Glu Asp Phe His Tyr Gly Met Val Val Thr Tyr Arg Cys Asn Thr Asp 
225                 230                 235                 240 


Ala Arg Gly Lys Ala Leu Phe Asn Leu Val Gly Glu Pro Ser Leu Tyr 
                245                 250                 255     


Cys Thr Ser Asn Asp Gly Glu Ile Gly Val Trp Ser Gly Pro Pro Pro 
            260                 265                 270         


Gln Cys Ile Glu Leu Asn Lys Cys Thr Pro Pro Pro Tyr Val Glu Asn 
        275                 280                 285             


Ala Val Met Leu Ser Glu Asn Arg Ser Leu Phe Ser Leu Arg Asp Ile 
    290                 295                 300                 


Val Glu Phe Arg Cys His Pro Gly Phe Ile Met Lys Gly Ala Ser Ser 
305                 310                 315                 320 


Val His Cys Gln Ser Leu Asn Lys Trp Glu Pro Glu Leu Pro Ser Cys 
                325                 330                 335     


Phe Lys Gly Val Ile Cys Arg Leu Pro Gln Glu Met Ser Gly Phe Gln 
            340                 345                 350         


Lys Gly Leu Gly Met Lys Lys Glu Tyr Tyr Tyr Gly Glu Asn Val Thr 
        355                 360                 365             


Leu Glu Cys Glu Asp Gly Tyr Thr Leu Glu Gly Ser Ser Gln Ser Gln 
    370                 375                 380                 


Cys Gln Ser Asp Gly Ser Trp Asn Pro Leu Leu Ala Lys Cys Val Ser 
385                 390                 395                 400 


Arg Ser Ile Ser Gly Leu Ile Val Gly Ile Phe Ile Gly Ile Ile Val 
                405                 410                 415     


Phe Ile Leu Val Ile Ile Val Phe Ile Trp Met Ile Leu Lys Tyr Lys 
            420                 425                 430         


Lys Arg Asn Thr Thr Asp Glu Lys Tyr Lys Glu Val Gly Ile His Leu 
        435                 440                 445             


Asn Tyr Lys Glu Asp Ser Cys Val Arg Leu Gln Ser Leu Leu Thr Ser 
    450                 455                 460                 


Gln Glu Asn Ser Ser Thr Thr Ser Pro Ala Arg Asn Ser Leu Thr Gln 
465                 470                 475                 480 


Glu Val Ser 
            


<210>  10
<211>  2039
<212>  PRT
<213>  Homo sapiens

<400>  10

Met Gly Ala Ser Ser Pro Arg Ser Pro Glu Pro Val Gly Pro Pro Ala 
1               5                   10                  15      


Pro Gly Leu Pro Phe Cys Cys Gly Gly Ser Leu Leu Ala Val Val Val 
            20                  25                  30          


Leu Leu Ala Leu Pro Val Ala Trp Gly Gln Cys Asn Ala Pro Glu Trp 
        35                  40                  45              


Leu Pro Phe Ala Arg Pro Thr Asn Leu Thr Asp Glu Phe Glu Phe Pro 
    50                  55                  60                  


Ile Gly Thr Tyr Leu Asn Tyr Glu Cys Arg Pro Gly Tyr Ser Gly Arg 
65                  70                  75                  80  


Pro Phe Ser Ile Ile Cys Leu Lys Asn Ser Val Trp Thr Gly Ala Lys 
                85                  90                  95      


Asp Arg Cys Arg Arg Lys Ser Cys Arg Asn Pro Pro Asp Pro Val Asn 
            100                 105                 110         


Gly Met Val His Val Ile Lys Gly Ile Gln Phe Gly Ser Gln Ile Lys 
        115                 120                 125             


Tyr Ser Cys Thr Lys Gly Tyr Arg Leu Ile Gly Ser Ser Ser Ala Thr 
    130                 135                 140                 


Cys Ile Ile Ser Gly Asp Thr Val Ile Trp Asp Asn Glu Thr Pro Ile 
145                 150                 155                 160 


Cys Asp Arg Ile Pro Cys Gly Leu Pro Pro Thr Ile Thr Asn Gly Asp 
                165                 170                 175     


Phe Ile Ser Thr Asn Arg Glu Asn Phe His Tyr Gly Ser Val Val Thr 
            180                 185                 190         


Tyr Arg Cys Asn Pro Gly Ser Gly Gly Arg Lys Val Phe Glu Leu Val 
        195                 200                 205             


Gly Glu Pro Ser Ile Tyr Cys Thr Ser Asn Asp Asp Gln Val Gly Ile 
    210                 215                 220                 


Trp Ser Gly Pro Ala Pro Gln Cys Ile Ile Pro Asn Lys Cys Thr Pro 
225                 230                 235                 240 


Pro Asn Val Glu Asn Gly Ile Leu Val Ser Asp Asn Arg Ser Leu Phe 
                245                 250                 255     


Ser Leu Asn Glu Val Val Glu Phe Arg Cys Gln Pro Gly Phe Val Met 
            260                 265                 270         


Lys Gly Pro Arg Arg Val Lys Cys Gln Ala Leu Asn Lys Trp Glu Pro 
        275                 280                 285             


Glu Leu Pro Ser Cys Ser Arg Val Cys Gln Pro Pro Pro Asp Val Leu 
    290                 295                 300                 


His Ala Glu Arg Thr Gln Arg Asp Lys Asp Asn Phe Ser Pro Gly Gln 
305                 310                 315                 320 


Glu Val Phe Tyr Ser Cys Glu Pro Gly Tyr Asp Leu Arg Gly Ala Ala 
                325                 330                 335     


Ser Met Arg Cys Thr Pro Gln Gly Asp Trp Ser Pro Ala Ala Pro Thr 
            340                 345                 350         


Cys Glu Val Lys Ser Cys Asp Asp Phe Met Gly Gln Leu Leu Asn Gly 
        355                 360                 365             


Arg Val Leu Phe Pro Val Asn Leu Gln Leu Gly Ala Lys Val Asp Phe 
    370                 375                 380                 


Val Cys Asp Glu Gly Phe Gln Leu Lys Gly Ser Ser Ala Ser Tyr Cys 
385                 390                 395                 400 


Val Leu Ala Gly Met Glu Ser Leu Trp Asn Ser Ser Val Pro Val Cys 
                405                 410                 415     


Glu Gln Ile Phe Cys Pro Ser Pro Pro Val Ile Pro Asn Gly Arg His 
            420                 425                 430         


Thr Gly Lys Pro Leu Glu Val Phe Pro Phe Gly Lys Ala Val Asn Tyr 
        435                 440                 445             


Thr Cys Asp Pro His Pro Asp Arg Gly Thr Ser Phe Asp Leu Ile Gly 
    450                 455                 460                 


Glu Ser Thr Ile Arg Cys Thr Ser Asp Pro Gln Gly Asn Gly Val Trp 
465                 470                 475                 480 


Ser Ser Pro Ala Pro Arg Cys Gly Ile Leu Gly His Cys Gln Ala Pro 
                485                 490                 495     


Asp His Phe Leu Phe Ala Lys Leu Lys Thr Gln Thr Asn Ala Ser Asp 
            500                 505                 510         


Phe Pro Ile Gly Thr Ser Leu Lys Tyr Glu Cys Arg Pro Glu Tyr Tyr 
        515                 520                 525             


Gly Arg Pro Phe Ser Ile Thr Cys Leu Asp Asn Leu Val Trp Ser Ser 
    530                 535                 540                 


Pro Lys Asp Val Cys Lys Arg Lys Ser Cys Lys Thr Pro Pro Asp Pro 
545                 550                 555                 560 


Val Asn Gly Met Val His Val Ile Thr Asp Ile Gln Val Gly Ser Arg 
                565                 570                 575     


Ile Asn Tyr Ser Cys Thr Thr Gly His Arg Leu Ile Gly His Ser Ser 
            580                 585                 590         


Ala Glu Cys Ile Leu Ser Gly Asn Ala Ala His Trp Ser Thr Lys Pro 
        595                 600                 605             


Pro Ile Cys Gln Arg Ile Pro Cys Gly Leu Pro Pro Thr Ile Ala Asn 
    610                 615                 620                 


Gly Asp Phe Ile Ser Thr Asn Arg Glu Asn Phe His Tyr Gly Ser Val 
625                 630                 635                 640 


Val Thr Tyr Arg Cys Asn Pro Gly Ser Gly Gly Arg Lys Val Phe Glu 
                645                 650                 655     


Leu Val Gly Glu Pro Ser Ile Tyr Cys Thr Ser Asn Asp Asp Gln Val 
            660                 665                 670         


Gly Ile Trp Ser Gly Pro Ala Pro Gln Cys Ile Ile Pro Asn Lys Cys 
        675                 680                 685             


Thr Pro Pro Asn Val Glu Asn Gly Ile Leu Val Ser Asp Asn Arg Ser 
    690                 695                 700                 


Leu Phe Ser Leu Asn Glu Val Val Glu Phe Arg Cys Gln Pro Gly Phe 
705                 710                 715                 720 


Val Met Lys Gly Pro Arg Arg Val Lys Cys Gln Ala Leu Asn Lys Trp 
                725                 730                 735     


Glu Pro Glu Leu Pro Ser Cys Ser Arg Val Cys Gln Pro Pro Pro Asp 
            740                 745                 750         


Val Leu His Ala Glu Arg Thr Gln Arg Asp Lys Asp Asn Phe Ser Pro 
        755                 760                 765             


Gly Gln Glu Val Phe Tyr Ser Cys Glu Pro Gly Tyr Asp Leu Arg Gly 
    770                 775                 780                 


Ala Ala Ser Met Arg Cys Thr Pro Gln Gly Asp Trp Ser Pro Ala Ala 
785                 790                 795                 800 


Pro Thr Cys Glu Val Lys Ser Cys Asp Asp Phe Met Gly Gln Leu Leu 
                805                 810                 815     


Asn Gly Arg Val Leu Phe Pro Val Asn Leu Gln Leu Gly Ala Lys Val 
            820                 825                 830         


Asp Phe Val Cys Asp Glu Gly Phe Gln Leu Lys Gly Ser Ser Ala Ser 
        835                 840                 845             


Tyr Cys Val Leu Ala Gly Met Glu Ser Leu Trp Asn Ser Ser Val Pro 
    850                 855                 860                 


Val Cys Glu Gln Ile Phe Cys Pro Ser Pro Pro Val Ile Pro Asn Gly 
865                 870                 875                 880 


Arg His Thr Gly Lys Pro Leu Glu Val Phe Pro Phe Gly Lys Ala Val 
                885                 890                 895     


Asn Tyr Thr Cys Asp Pro His Pro Asp Arg Gly Thr Ser Phe Asp Leu 
            900                 905                 910         


Ile Gly Glu Ser Thr Ile Arg Cys Thr Ser Asp Pro Gln Gly Asn Gly 
        915                 920                 925             


Val Trp Ser Ser Pro Ala Pro Arg Cys Gly Ile Leu Gly His Cys Gln 
    930                 935                 940                 


Ala Pro Asp His Phe Leu Phe Ala Lys Leu Lys Thr Gln Thr Asn Ala 
945                 950                 955                 960 


Ser Asp Phe Pro Ile Gly Thr Ser Leu Lys Tyr Glu Cys Arg Pro Glu 
                965                 970                 975     


Tyr Tyr Gly Arg Pro Phe Ser Ile Thr Cys Leu Asp Asn Leu Val Trp 
            980                 985                 990         


Ser Ser Pro Lys Asp Val Cys Lys  Arg Lys Ser Cys Lys  Thr Pro Pro 
        995                 1000                 1005             


Asp Pro  Val Asn Gly Met Val  His Val Ile Thr Asp  Ile Gln Val 
    1010                 1015                 1020             


Gly Ser  Arg Ile Asn Tyr Ser  Cys Thr Thr Gly His  Arg Leu Ile 
    1025                 1030                 1035             


Gly His  Ser Ser Ala Glu Cys  Ile Leu Ser Gly Asn  Thr Ala His 
    1040                 1045                 1050             


Trp Ser  Thr Lys Pro Pro Ile  Cys Gln Arg Ile Pro  Cys Gly Leu 
    1055                 1060                 1065             


Pro Pro  Thr Ile Ala Asn Gly  Asp Phe Ile Ser Thr  Asn Arg Glu 
    1070                 1075                 1080             


Asn Phe  His Tyr Gly Ser Val  Val Thr Tyr Arg Cys  Asn Leu Gly 
    1085                 1090                 1095             


Ser Arg  Gly Arg Lys Val Phe  Glu Leu Val Gly Glu  Pro Ser Ile 
    1100                 1105                 1110             


Tyr Cys  Thr Ser Asn Asp Asp  Gln Val Gly Ile Trp  Ser Gly Pro 
    1115                 1120                 1125             


Ala Pro  Gln Cys Ile Ile Pro  Asn Lys Cys Thr Pro  Pro Asn Val 
    1130                 1135                 1140             


Glu Asn  Gly Ile Leu Val Ser  Asp Asn Arg Ser Leu  Phe Ser Leu 
    1145                 1150                 1155             


Asn Glu  Val Val Glu Phe Arg  Cys Gln Pro Gly Phe  Val Met Lys 
    1160                 1165                 1170             


Gly Pro  Arg Arg Val Lys Cys  Gln Ala Leu Asn Lys  Trp Glu Pro 
    1175                 1180                 1185             


Glu Leu  Pro Ser Cys Ser Arg  Val Cys Gln Pro Pro  Pro Glu Ile 
    1190                 1195                 1200             


Leu His  Gly Glu His Thr Pro  Ser His Gln Asp Asn  Phe Ser Pro 
    1205                 1210                 1215             


Gly Gln  Glu Val Phe Tyr Ser  Cys Glu Pro Gly Tyr  Asp Leu Arg 
    1220                 1225                 1230             


Gly Ala  Ala Ser Leu His Cys  Thr Pro Gln Gly Asp  Trp Ser Pro 
    1235                 1240                 1245             


Glu Ala  Pro Arg Cys Ala Val  Lys Ser Cys Asp Asp  Phe Leu Gly 
    1250                 1255                 1260             


Gln Leu  Pro His Gly Arg Val  Leu Phe Pro Leu Asn  Leu Gln Leu 
    1265                 1270                 1275             


Gly Ala  Lys Val Ser Phe Val  Cys Asp Glu Gly Phe  Arg Leu Lys 
    1280                 1285                 1290             


Gly Ser  Ser Val Ser His Cys  Val Leu Val Gly Met  Arg Ser Leu 
    1295                 1300                 1305             


Trp Asn  Asn Ser Val Pro Val  Cys Glu His Ile Phe  Cys Pro Asn 
    1310                 1315                 1320             


Pro Pro  Ala Ile Leu Asn Gly  Arg His Thr Gly Thr  Pro Ser Gly 
    1325                 1330                 1335             


Asp Ile  Pro Tyr Gly Lys Glu  Ile Ser Tyr Thr Cys  Asp Pro His 
    1340                 1345                 1350             


Pro Asp  Arg Gly Met Thr Phe  Asn Leu Ile Gly Glu  Ser Thr Ile 
    1355                 1360                 1365             


Arg Cys  Thr Ser Asp Pro His  Gly Asn Gly Val Trp  Ser Ser Pro 
    1370                 1375                 1380             


Ala Pro  Arg Cys Glu Leu Ser  Val Arg Ala Gly His  Cys Lys Thr 
    1385                 1390                 1395             


Pro Glu  Gln Phe Pro Phe Ala  Ser Pro Thr Ile Pro  Ile Asn Asp 
    1400                 1405                 1410             


Phe Glu  Phe Pro Val Gly Thr  Ser Leu Asn Tyr Glu  Cys Arg Pro 
    1415                 1420                 1425             


Gly Tyr  Phe Gly Lys Met Phe  Ser Ile Ser Cys Leu  Glu Asn Leu 
    1430                 1435                 1440             


Val Trp  Ser Ser Val Glu Asp  Asn Cys Arg Arg Lys  Ser Cys Gly 
    1445                 1450                 1455             


Pro Pro  Pro Glu Pro Phe Asn  Gly Met Val His Ile  Asn Thr Asp 
    1460                 1465                 1470             


Thr Gln  Phe Gly Ser Thr Val  Asn Tyr Ser Cys Asn  Glu Gly Phe 
    1475                 1480                 1485             


Arg Leu  Ile Gly Ser Pro Ser  Thr Thr Cys Leu Val  Ser Gly Asn 
    1490                 1495                 1500             


Asn Val  Thr Trp Asp Lys Lys  Ala Pro Ile Cys Glu  Ile Ile Ser 
    1505                 1510                 1515             


Cys Glu  Pro Pro Pro Thr Ile  Ser Asn Gly Asp Phe  Tyr Ser Asn 
    1520                 1525                 1530             


Asn Arg  Thr Ser Phe His Asn  Gly Thr Val Val Thr  Tyr Gln Cys 
    1535                 1540                 1545             


His Thr  Gly Pro Asp Gly Glu  Gln Leu Phe Glu Leu  Val Gly Glu 
    1550                 1555                 1560             


Arg Ser  Ile Tyr Cys Thr Ser  Lys Asp Asp Gln Val  Gly Val Trp 
    1565                 1570                 1575             


Ser Ser  Pro Pro Pro Arg Cys  Ile Ser Thr Asn Lys  Cys Thr Ala 
    1580                 1585                 1590             


Pro Glu  Val Glu Asn Ala Ile  Arg Val Pro Gly Asn  Arg Ser Phe 
    1595                 1600                 1605             


Phe Ser  Leu Thr Glu Ile Ile  Arg Phe Arg Cys Gln  Pro Gly Phe 
    1610                 1615                 1620             


Val Met  Val Gly Ser His Thr  Val Gln Cys Gln Thr  Asn Gly Arg 
    1625                 1630                 1635             


Trp Gly  Pro Lys Leu Pro His  Cys Ser Arg Val Cys  Gln Pro Pro 
    1640                 1645                 1650             


Pro Glu  Ile Leu His Gly Glu  His Thr Leu Ser His  Gln Asp Asn 
    1655                 1660                 1665             


Phe Ser  Pro Gly Gln Glu Val  Phe Tyr Ser Cys Glu  Pro Ser Tyr 
    1670                 1675                 1680             


Asp Leu  Arg Gly Ala Ala Ser  Leu His Cys Thr Pro  Gln Gly Asp 
    1685                 1690                 1695             


Trp Ser  Pro Glu Ala Pro Arg  Cys Thr Val Lys Ser  Cys Asp Asp 
    1700                 1705                 1710             


Phe Leu  Gly Gln Leu Pro His  Gly Arg Val Leu Leu  Pro Leu Asn 
    1715                 1720                 1725             


Leu Gln  Leu Gly Ala Lys Val  Ser Phe Val Cys Asp  Glu Gly Phe 
    1730                 1735                 1740             


Arg Leu  Lys Gly Arg Ser Ala  Ser His Cys Val Leu  Ala Gly Met 
    1745                 1750                 1755             


Lys Ala  Leu Trp Asn Ser Ser  Val Pro Val Cys Glu  Gln Ile Phe 
    1760                 1765                 1770             


Cys Pro  Asn Pro Pro Ala Ile  Leu Asn Gly Arg His  Thr Gly Thr 
    1775                 1780                 1785             


Pro Phe  Gly Asp Ile Pro Tyr  Gly Lys Glu Ile Ser  Tyr Ala Cys 
    1790                 1795                 1800             


Asp Thr  His Pro Asp Arg Gly  Met Thr Phe Asn Leu  Ile Gly Glu 
    1805                 1810                 1815             


Ser Ser  Ile Arg Cys Thr Ser  Asp Pro Gln Gly Asn  Gly Val Trp 
    1820                 1825                 1830             


Ser Ser  Pro Ala Pro Arg Cys  Glu Leu Ser Val Pro  Ala Ala Cys 
    1835                 1840                 1845             


Pro His  Pro Pro Lys Ile Gln  Asn Gly His Tyr Ile  Gly Gly His 
    1850                 1855                 1860             


Val Ser  Leu Tyr Leu Pro Gly  Met Thr Ile Ser Tyr  Thr Cys Asp 
    1865                 1870                 1875             


Pro Gly  Tyr Leu Leu Val Gly  Lys Gly Phe Ile Phe  Cys Thr Asp 
    1880                 1885                 1890             


Gln Gly  Ile Trp Ser Gln Leu  Asp His Tyr Cys Lys  Glu Val Asn 
    1895                 1900                 1905             


Cys Ser  Phe Pro Leu Phe Met  Asn Gly Ile Ser Lys  Glu Leu Glu 
    1910                 1915                 1920             


Met Lys  Lys Val Tyr His Tyr  Gly Asp Tyr Val Thr  Leu Lys Cys 
    1925                 1930                 1935             


Glu Asp  Gly Tyr Thr Leu Glu  Gly Ser Pro Trp Ser  Gln Cys Gln 
    1940                 1945                 1950             


Ala Asp  Asp Arg Trp Asp Pro  Pro Leu Ala Lys Cys  Thr Ser Arg 
    1955                 1960                 1965             


Ala His  Asp Ala Leu Ile Val  Gly Thr Leu Ser Gly  Thr Ile Phe 
    1970                 1975                 1980             


Phe Ile  Leu Leu Ile Ile Phe  Leu Ser Trp Ile Ile  Leu Lys His 
    1985                 1990                 1995             


Arg Lys  Gly Asn Asn Ala His  Glu Asn Pro Lys Glu  Val Ala Ile 
    2000                 2005                 2010             


His Leu  His Ser Gln Gly Gly  Ser Ser Val His Pro  Arg Thr Leu 
    2015                 2020                 2025             


Gln Thr  Asn Glu Glu Asn Ser  Arg Val Leu Pro 
    2030                 2035                 


<210>  11
<211>  1231
<212>  PRT
<213>  Homo sapiens

<400>  11

Met Arg Leu Leu Ala Lys Ile Ile Cys Leu Met Leu Trp Ala Ile Cys 
1               5                   10                  15      


Val Ala Glu Asp Cys Asn Glu Leu Pro Pro Arg Arg Asn Thr Glu Ile 
            20                  25                  30          


Leu Thr Gly Ser Trp Ser Asp Gln Thr Tyr Pro Glu Gly Thr Gln Ala 
        35                  40                  45              


Ile Tyr Lys Cys Arg Pro Gly Tyr Arg Ser Leu Gly Asn Val Ile Met 
    50                  55                  60                  


Val Cys Arg Lys Gly Glu Trp Val Ala Leu Asn Pro Leu Arg Lys Cys 
65                  70                  75                  80  


Gln Lys Arg Pro Cys Gly His Pro Gly Asp Thr Pro Phe Gly Thr Phe 
                85                  90                  95      


Thr Leu Thr Gly Gly Asn Val Phe Glu Tyr Gly Val Lys Ala Val Tyr 
            100                 105                 110         


Thr Cys Asn Glu Gly Tyr Gln Leu Leu Gly Glu Ile Asn Tyr Arg Glu 
        115                 120                 125             


Cys Asp Thr Asp Gly Trp Thr Asn Asp Ile Pro Ile Cys Glu Val Val 
    130                 135                 140                 


Lys Cys Leu Pro Val Thr Ala Pro Glu Asn Gly Lys Ile Val Ser Ser 
145                 150                 155                 160 


Ala Met Glu Pro Asp Arg Glu Tyr His Phe Gly Gln Ala Val Arg Phe 
                165                 170                 175     


Val Cys Asn Ser Gly Tyr Lys Ile Glu Gly Asp Glu Glu Met His Cys 
            180                 185                 190         


Ser Asp Asp Gly Phe Trp Ser Lys Glu Lys Pro Lys Cys Val Glu Ile 
        195                 200                 205             


Ser Cys Lys Ser Pro Asp Val Ile Asn Gly Ser Pro Ile Ser Gln Lys 
    210                 215                 220                 


Ile Ile Tyr Lys Glu Asn Glu Arg Phe Gln Tyr Lys Cys Asn Met Gly 
225                 230                 235                 240 


Tyr Glu Tyr Ser Glu Arg Gly Asp Ala Val Cys Thr Glu Ser Gly Trp 
                245                 250                 255     


Arg Pro Leu Pro Ser Cys Glu Glu Lys Ser Cys Asp Asn Pro Tyr Ile 
            260                 265                 270         


Pro Asn Gly Asp Tyr Ser Pro Leu Arg Ile Lys His Arg Thr Gly Asp 
        275                 280                 285             


Glu Ile Thr Tyr Gln Cys Arg Asn Gly Phe Tyr Pro Ala Thr Arg Gly 
    290                 295                 300                 


Asn Thr Ala Lys Cys Thr Ser Thr Gly Trp Ile Pro Ala Pro Arg Cys 
305                 310                 315                 320 


Thr Leu Lys Pro Cys Asp Tyr Pro Asp Ile Lys His Gly Gly Leu Tyr 
                325                 330                 335     


His Glu Asn Met Arg Arg Pro Tyr Phe Pro Val Ala Val Gly Lys Tyr 
            340                 345                 350         


Tyr Ser Tyr Tyr Cys Asp Glu His Phe Glu Thr Pro Ser Gly Ser Tyr 
        355                 360                 365             


Trp Asp His Ile His Cys Thr Gln Asp Gly Trp Ser Pro Ala Val Pro 
    370                 375                 380                 


Cys Leu Arg Lys Cys Tyr Phe Pro Tyr Leu Glu Asn Gly Tyr Asn Gln 
385                 390                 395                 400 


Asn Tyr Gly Arg Lys Phe Val Gln Gly Lys Ser Ile Asp Val Ala Cys 
                405                 410                 415     


His Pro Gly Tyr Ala Leu Pro Lys Ala Gln Thr Thr Val Thr Cys Met 
            420                 425                 430         


Glu Asn Gly Trp Ser Pro Thr Pro Arg Cys Ile Arg Val Lys Thr Cys 
        435                 440                 445             


Ser Lys Ser Ser Ile Asp Ile Glu Asn Gly Phe Ile Ser Glu Ser Gln 
    450                 455                 460                 


Tyr Thr Tyr Ala Leu Lys Glu Lys Ala Lys Tyr Gln Cys Lys Leu Gly 
465                 470                 475                 480 


Tyr Val Thr Ala Asp Gly Glu Thr Ser Gly Ser Ile Thr Cys Gly Lys 
                485                 490                 495     


Asp Gly Trp Ser Ala Gln Pro Thr Cys Ile Lys Ser Cys Asp Ile Pro 
            500                 505                 510         


Val Phe Met Asn Ala Arg Thr Lys Asn Asp Phe Thr Trp Phe Lys Leu 
        515                 520                 525             


Asn Asp Thr Leu Asp Tyr Glu Cys His Asp Gly Tyr Glu Ser Asn Thr 
    530                 535                 540                 


Gly Ser Thr Thr Gly Ser Ile Val Cys Gly Tyr Asn Gly Trp Ser Asp 
545                 550                 555                 560 


Leu Pro Ile Cys Tyr Glu Arg Glu Cys Glu Leu Pro Lys Ile Asp Val 
                565                 570                 575     


His Leu Val Pro Asp Arg Lys Lys Asp Gln Tyr Lys Val Gly Glu Val 
            580                 585                 590         


Leu Lys Phe Ser Cys Lys Pro Gly Phe Phe Ile Val Gly Pro Asn Ser 
        595                 600                 605             


Val Gln Cys Tyr His Phe Gly Leu Ser Pro Asp Leu Pro Ile Cys Lys 
    610                 615                 620                 


Glu Gln Val Gln Ser Cys Gly Pro Pro Pro Glu Leu Leu Asn Gly Asn 
625                 630                 635                 640 


Val Lys Glu Lys Thr Lys Glu Glu Tyr Gly His Ser Glu Val Val Glu 
                645                 650                 655     


Tyr Tyr Cys Asn Pro Arg Phe Leu Met Lys Gly Pro Asn Lys Ile Gln 
            660                 665                 670         


Cys Val Asp Gly Glu Trp Thr Thr Leu Pro Val Cys Ile Val Glu Glu 
        675                 680                 685             


Ser Thr Cys Gly Asp Ile Pro Glu Leu Glu His Gly Trp Ala Gln Leu 
    690                 695                 700                 


Ser Ser Pro Pro Tyr Tyr Tyr Gly Asp Ser Val Glu Phe Asn Cys Ser 
705                 710                 715                 720 


Glu Ser Phe Thr Met Ile Gly His Arg Ser Ile Thr Cys Ile His Gly 
                725                 730                 735     


Val Trp Thr Gln Leu Pro Gln Cys Val Ala Ile Asp Lys Leu Lys Lys 
            740                 745                 750         


Cys Lys Ser Ser Asn Leu Ile Ile Leu Glu Glu His Leu Lys Asn Lys 
        755                 760                 765             


Lys Glu Phe Asp His Asn Ser Asn Ile Arg Tyr Arg Cys Arg Gly Lys 
    770                 775                 780                 


Glu Gly Trp Ile His Thr Val Cys Ile Asn Gly Arg Trp Asp Pro Glu 
785                 790                 795                 800 


Val Asn Cys Ser Met Ala Gln Ile Gln Leu Cys Pro Pro Pro Pro Gln 
                805                 810                 815     


Ile Pro Asn Ser His Asn Met Thr Thr Thr Leu Asn Tyr Arg Asp Gly 
            820                 825                 830         


Glu Lys Val Ser Val Leu Cys Gln Glu Asn Tyr Leu Ile Gln Glu Gly 
        835                 840                 845             


Glu Glu Ile Thr Cys Lys Asp Gly Arg Trp Gln Ser Ile Pro Leu Cys 
    850                 855                 860                 


Val Glu Lys Ile Pro Cys Ser Gln Pro Pro Gln Ile Glu His Gly Thr 
865                 870                 875                 880 


Ile Asn Ser Ser Arg Ser Ser Gln Glu Ser Tyr Ala His Gly Thr Lys 
                885                 890                 895     


Leu Ser Tyr Thr Cys Glu Gly Gly Phe Arg Ile Ser Glu Glu Asn Glu 
            900                 905                 910         


Thr Thr Cys Tyr Met Gly Lys Trp Ser Ser Pro Pro Gln Cys Glu Gly 
        915                 920                 925             


Leu Pro Cys Lys Ser Pro Pro Glu Ile Ser His Gly Val Val Ala His 
    930                 935                 940                 


Met Ser Asp Ser Tyr Gln Tyr Gly Glu Glu Val Thr Tyr Lys Cys Phe 
945                 950                 955                 960 


Glu Gly Phe Gly Ile Asp Gly Pro Ala Ile Ala Lys Cys Leu Gly Glu 
                965                 970                 975     


Lys Trp Ser His Pro Pro Ser Cys Ile Lys Thr Asp Cys Leu Ser Leu 
            980                 985                 990         


Pro Ser Phe Glu Asn Ala Ile Pro  Met Gly Glu Lys Lys  Asp Val Tyr 
        995                 1000                 1005             


Lys Ala  Gly Glu Gln Val Thr  Tyr Thr Cys Ala Thr  Tyr Tyr Lys 
    1010                 1015                 1020             


Met Asp  Gly Ala Ser Asn Val  Thr Cys Ile Asn Ser  Arg Trp Thr 
    1025                 1030                 1035             


Gly Arg  Pro Thr Cys Arg Asp  Thr Ser Cys Val Asn  Pro Pro Thr 
    1040                 1045                 1050             


Val Gln  Asn Ala Tyr Ile Val  Ser Arg Gln Met Ser  Lys Tyr Pro 
    1055                 1060                 1065             


Ser Gly  Glu Arg Val Arg Tyr  Gln Cys Arg Ser Pro  Tyr Glu Met 
    1070                 1075                 1080             


Phe Gly  Asp Glu Glu Val Met  Cys Leu Asn Gly Asn  Trp Thr Glu 
    1085                 1090                 1095             


Pro Pro  Gln Cys Lys Asp Ser  Thr Gly Lys Cys Gly  Pro Pro Pro 
    1100                 1105                 1110             


Pro Ile  Asp Asn Gly Asp Ile  Thr Ser Phe Pro Leu  Ser Val Tyr 
    1115                 1120                 1125             


Ala Pro  Ala Ser Ser Val Glu  Tyr Gln Cys Gln Asn  Leu Tyr Gln 
    1130                 1135                 1140             


Leu Glu  Gly Asn Lys Arg Ile  Thr Cys Arg Asn Gly  Gln Trp Ser 
    1145                 1150                 1155             


Glu Pro  Pro Lys Cys Leu His  Pro Cys Val Ile Ser  Arg Glu Ile 
    1160                 1165                 1170             


Met Glu  Asn Tyr Asn Ile Ala  Leu Arg Trp Thr Ala  Lys Gln Lys 
    1175                 1180                 1185             


Leu Tyr  Ser Arg Thr Gly Glu  Ser Val Glu Phe Val  Cys Lys Arg 
    1190                 1195                 1200             


Gly Tyr  Arg Leu Ser Ser Arg  Ser His Thr Leu Arg  Thr Thr Cys 
    1205                 1210                 1215             


Trp Asp  Gly Lys Leu Glu Tyr  Pro Thr Cys Ala Lys  Arg 
    1220                 1225                 1230     


<210>  12
<211>  1234
<212>  PRT
<213>  Mus musculus

<400>  12

Met Arg Leu Ser Ala Arg Ile Ile Trp Leu Ile Leu Trp Thr Val Cys 
1               5                   10                  15      


Ala Ala Glu Asp Cys Lys Gly Pro Pro Pro Arg Glu Asn Ser Glu Ile 
            20                  25                  30          


Leu Ser Gly Ser Trp Ser Glu Gln Leu Tyr Pro Glu Gly Thr Gln Ala 
        35                  40                  45              


Thr Tyr Lys Cys Arg Pro Gly Tyr Arg Thr Leu Gly Thr Ile Val Lys 
    50                  55                  60                  


Val Cys Lys Asn Gly Lys Trp Val Ala Ser Asn Pro Ser Arg Ile Cys 
65                  70                  75                  80  


Arg Lys Lys Pro Cys Gly His Pro Gly Asp Thr Pro Phe Gly Ser Phe 
                85                  90                  95      


Arg Leu Ala Val Gly Ser Gln Phe Glu Phe Gly Ala Lys Val Val Tyr 
            100                 105                 110         


Thr Cys Asp Asp Gly Tyr Gln Leu Leu Gly Glu Ile Asp Tyr Arg Glu 
        115                 120                 125             


Cys Gly Ala Asp Gly Trp Ile Asn Asp Ile Pro Leu Cys Glu Val Val 
    130                 135                 140                 


Lys Cys Leu Pro Val Thr Glu Leu Glu Asn Gly Arg Ile Val Ser Gly 
145                 150                 155                 160 


Ala Ala Glu Thr Asp Gln Glu Tyr Tyr Phe Gly Gln Val Val Arg Phe 
                165                 170                 175     


Glu Cys Asn Ser Gly Phe Lys Ile Glu Gly His Lys Glu Ile His Cys 
            180                 185                 190         


Ser Glu Asn Gly Leu Trp Ser Asn Glu Lys Pro Arg Cys Val Glu Ile 
        195                 200                 205             


Leu Cys Thr Pro Pro Arg Val Glu Asn Gly Asp Gly Ile Asn Val Lys 
    210                 215                 220                 


Pro Val Tyr Lys Glu Asn Glu Arg Tyr His Tyr Lys Cys Lys His Gly 
225                 230                 235                 240 


Tyr Val Pro Lys Glu Arg Gly Asp Ala Val Cys Thr Gly Ser Gly Trp 
                245                 250                 255     


Ser Ser Gln Pro Phe Cys Glu Glu Lys Arg Cys Ser Pro Pro Tyr Ile 
            260                 265                 270         


Leu Asn Gly Ile Tyr Thr Pro His Arg Ile Ile His Arg Ser Asp Asp 
        275                 280                 285             


Glu Ile Arg Tyr Glu Cys Asn Tyr Gly Phe Tyr Pro Val Thr Gly Ser 
    290                 295                 300                 


Thr Val Ser Lys Cys Thr Pro Thr Gly Trp Ile Pro Val Pro Arg Cys 
305                 310                 315                 320 


Thr Leu Lys Pro Cys Glu Phe Pro Gln Phe Lys Tyr Gly Arg Leu Tyr 
                325                 330                 335     


Tyr Glu Glu Ser Leu Arg Pro Asn Phe Pro Val Ser Ile Gly Asn Lys 
            340                 345                 350         


Tyr Ser Tyr Lys Cys Asp Asn Gly Phe Ser Pro Pro Ser Gly Tyr Ser 
        355                 360                 365             


Trp Asp Tyr Leu Arg Cys Thr Ala Gln Gly Trp Glu Pro Glu Val Pro 
    370                 375                 380                 


Cys Val Arg Lys Cys Val Phe His Tyr Val Glu Asn Gly Asp Ser Ala 
385                 390                 395                 400 


Tyr Trp Glu Lys Val Tyr Val Gln Gly Gln Ser Leu Lys Val Gln Cys 
                405                 410                 415     


Tyr Asn Gly Tyr Ser Leu Gln Asn Gly Gln Asp Thr Met Thr Cys Thr 
            420                 425                 430         


Glu Asn Gly Trp Ser Pro Pro Pro Lys Cys Ile Arg Ile Lys Thr Cys 
        435                 440                 445             


Ser Ala Ser Asp Ile His Ile Asp Asn Gly Phe Leu Ser Glu Ser Ser 
    450                 455                 460                 


Ser Ile Tyr Ala Leu Asn Arg Glu Thr Ser Tyr Arg Cys Lys Gln Gly 
465                 470                 475                 480 


Tyr Val Thr Asn Thr Gly Glu Ile Ser Gly Ser Ile Thr Cys Leu Gln 
                485                 490                 495     


Asn Gly Trp Ser Pro Gln Pro Ser Cys Ile Lys Ser Cys Asp Met Pro 
            500                 505                 510         


Val Phe Glu Asn Ser Ile Thr Lys Asn Thr Arg Thr Trp Phe Lys Leu 
        515                 520                 525             


Asn Asp Lys Leu Asp Tyr Glu Cys Leu Val Gly Phe Glu Asn Glu Tyr 
    530                 535                 540                 


Lys His Thr Lys Gly Ser Ile Thr Cys Thr Tyr Tyr Gly Trp Ser Asp 
545                 550                 555                 560 


Thr Pro Ser Cys Tyr Glu Arg Glu Cys Ser Val Pro Thr Leu Asp Arg 
                565                 570                 575     


Lys Leu Val Val Ser Pro Arg Lys Glu Lys Tyr Arg Val Gly Asp Leu 
            580                 585                 590         


Leu Glu Phe Ser Cys His Ser Gly His Arg Val Gly Pro Asp Ser Val 
        595                 600                 605             


Gln Cys Tyr His Phe Gly Trp Ser Pro Gly Phe Pro Thr Cys Lys Gly 
    610                 615                 620                 


Gln Val Ala Ser Cys Ala Pro Pro Leu Glu Ile Leu Asn Gly Glu Ile 
625                 630                 635                 640 


Asn Gly Ala Lys Lys Val Glu Tyr Ser His Gly Glu Val Val Lys Tyr 
                645                 650                 655     


Asp Cys Lys Pro Arg Phe Leu Leu Lys Gly Pro Asn Lys Ile Gln Cys 
            660                 665                 670         


Val Asp Gly Asn Trp Thr Thr Leu Pro Val Cys Ile Glu Glu Glu Arg 
        675                 680                 685             


Thr Cys Gly Asp Ile Pro Glu Leu Glu His Gly Ser Ala Lys Cys Ser 
    690                 695                 700                 


Val Pro Pro Tyr His His Gly Asp Ser Val Glu Phe Ile Cys Glu Glu 
705                 710                 715                 720 


Asn Phe Phe Met Ile Gly His Gly Ser Val Ser Cys Ile Ser Gly Lys 
                725                 730                 735     


Trp Thr Gln Leu Pro Lys Cys Val Ala Thr Asp Gln Leu Glu Lys Cys 
            740                 745                 750         


Arg Val Leu Lys Ser Thr Gly Ile Glu Ala Ile Lys Pro Lys Leu Thr 
        755                 760                 765             


Glu Phe Phe His Asn Ser Thr Met Asp Tyr Lys Cys Arg Asp Lys Gln 
    770                 775                 780                 


Glu Tyr Glu Arg Ser Ile Cys Ile Asn Gly Lys Trp Asp Pro Glu Pro 
785                 790                 795                 800 


Asn Cys Thr Ser Lys Thr Ser Cys Pro Pro Pro Pro Gln Ile Pro Asn 
                805                 810                 815     


Thr Gln Val Ile Glu Thr Thr Val Lys Tyr Leu Asp Gly Glu Lys Leu 
            820                 825                 830         


Ser Val Leu Cys Gln Asp Asn Tyr Leu Thr Gln Asp Ser Glu Glu Met 
        835                 840                 845             


Val Cys Lys Asp Gly Arg Trp Gln Ser Leu Pro Arg Cys Ile Glu Lys 
    850                 855                 860                 


Ile Pro Cys Ser Gln Pro Pro Thr Ile Glu His Gly Ser Ile Asn Leu 
865                 870                 875                 880 


Pro Arg Ser Ser Glu Glu Arg Arg Asp Ser Ile Glu Ser Ser Ser His 
                885                 890                 895     


Glu His Gly Thr Thr Phe Ser Tyr Val Cys Asp Asp Gly Phe Arg Ile 
            900                 905                 910         


Pro Glu Glu Asn Arg Ile Thr Cys Tyr Met Gly Lys Trp Ser Thr Pro 
        915                 920                 925             


Pro Arg Cys Val Gly Leu Pro Cys Gly Pro Pro Pro Ser Ile Pro Leu 
    930                 935                 940                 


Gly Thr Val Ser Leu Glu Leu Glu Ser Tyr Gln His Gly Glu Glu Val 
945                 950                 955                 960 


Thr Tyr His Cys Ser Thr Gly Phe Gly Ile Asp Gly Pro Ala Phe Ile 
                965                 970                 975     


Ile Cys Glu Gly Gly Lys Trp Ser Asp Pro Pro Lys Cys Ile Lys Thr 
            980                 985                 990         


Asp Cys Asp Val Leu Pro Thr Val  Lys Asn Ala Ile Ile  Arg Gly Lys 
        995                 1000                 1005             


Ser Lys  Lys Ser Tyr Arg Thr  Gly Glu Gln Val Thr  Phe Arg Cys 
    1010                 1015                 1020             


Gln Ser  Pro Tyr Gln Met Asn  Gly Ser Asp Thr Val  Thr Cys Val 
    1025                 1030                 1035             


Asn Ser  Arg Trp Ile Gly Gln  Pro Val Cys Lys Asp  Asn Ser Cys 
    1040                 1045                 1050             


Val Asp  Pro Pro His Val Pro  Asn Ala Thr Ile Val  Thr Arg Thr 
    1055                 1060                 1065             


Lys Asn  Lys Tyr Leu His Gly  Asp Arg Val Arg Tyr  Glu Cys Asn 
    1070                 1075                 1080             


Lys Pro  Leu Glu Leu Phe Gly  Gln Val Glu Val Met  Cys Glu Asn 
    1085                 1090                 1095             


Gly Ile  Trp Thr Glu Lys Pro  Lys Cys Arg Asp Ser  Thr Gly Lys 
    1100                 1105                 1110             


Cys Gly  Pro Pro Pro Pro Ile  Asp Asn Gly Asp Ile  Thr Ser Leu 
    1115                 1120                 1125             


Ser Leu  Pro Val Tyr Glu Pro  Leu Ser Ser Val Glu  Tyr Gln Cys 
    1130                 1135                 1140             


Gln Lys  Tyr Tyr Leu Leu Lys  Gly Lys Lys Thr Ile  Thr Cys Thr 
    1145                 1150                 1155             


Asn Gly  Lys Trp Ser Glu Pro  Pro Thr Cys Leu His  Ala Cys Val 
    1160                 1165                 1170             


Ile Pro  Glu Asn Ile Met Glu  Ser His Asn Ile Ile  Leu Lys Trp 
    1175                 1180                 1185             


Arg His  Thr Glu Lys Ile Tyr  Ser His Ser Gly Glu  Asp Ile Glu 
    1190                 1195                 1200             


Phe Gly  Cys Lys Tyr Gly Tyr  Tyr Lys Ala Arg Asp  Ser Pro Pro 
    1205                 1210                 1215             


Phe Arg  Thr Lys Cys Ile Asn  Gly Thr Ile Asn Tyr  Pro Thr Cys 
    1220                 1225                 1230             


Val 
    


<210>  13
<211>  385
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  alternative splice product of MASP1

<400>  13

Met Arg Phe Leu Ser Phe Trp Arg Leu Leu Leu Tyr His Ala Leu Cys 
1               5                   10                  15      


Leu Ala Leu Pro Glu Val Ser Ala His Thr Val Glu Leu Asn Glu Met 
            20                  25                  30          


Phe Gly Gln Ile Gln Ser Pro Gly Tyr Pro Asp Ser Tyr Pro Ser Asp 
        35                  40                  45              


Ser Glu Val Thr Trp Asn Ile Thr Val Pro Glu Gly Phe Arg Ile Lys 
    50                  55                  60                  


Leu Tyr Phe Met His Phe Asn Leu Glu Ser Ser Tyr Leu Cys Glu Tyr 
65                  70                  75                  80  


Asp Tyr Val Lys Val Glu Thr Glu Asp Gln Val Leu Ala Thr Phe Cys 
                85                  90                  95      


Gly Arg Glu Thr Thr Asp Thr Glu Gln Thr Pro Gly Gln Glu Val Val 
            100                 105                 110         


Leu Ser Pro Gly Thr Phe Met Ser Val Thr Phe Arg Ser Asp Phe Ser 
        115                 120                 125             


Asn Glu Glu Arg Phe Thr Gly Phe Asp Ala His Tyr Met Ala Val Asp 
    130                 135                 140                 


Val Asp Glu Cys Lys Glu Arg Glu Asp Glu Glu Leu Ser Cys Asp His 
145                 150                 155                 160 


Tyr Cys His Asn Tyr Ile Gly Gly Tyr Tyr Cys Ser Cys Arg Phe Gly 
                165                 170                 175     


Tyr Ile Leu His Thr Asp Asn Arg Thr Cys Arg Val Glu Cys Ser Gly 
            180                 185                 190         


Asn Leu Phe Thr Gln Arg Thr Gly Thr Ile Thr Ser Pro Asp Tyr Pro 
        195                 200                 205             


Asn Pro Tyr Pro Lys Ser Ser Glu Cys Ser Tyr Thr Ile Asp Leu Glu 
    210                 215                 220                 


Glu Gly Phe Met Val Ser Leu Gln Phe Glu Asp Ile Phe Asp Ile Glu 
225                 230                 235                 240 


Asp His Pro Glu Val Pro Cys Pro Tyr Asp Tyr Ile Lys Ile Lys Ala 
                245                 250                 255     


Gly Ser Lys Val Trp Gly Pro Phe Cys Gly Glu Lys Ser Pro Glu Pro 
            260                 265                 270         


Ile Ser Thr Gln Thr His Ser Val Gln Ile Leu Phe Arg Ser Asp Asn 
        275                 280                 285             


Ser Gly Glu Asn Arg Gly Trp Arg Leu Ser Tyr Arg Ala Ala Gly Asn 
    290                 295                 300                 


Glu Cys Pro Lys Leu Gln Pro Pro Val Tyr Gly Lys Ile Glu Pro Ser 
305                 310                 315                 320 


Gln Ala Val Tyr Ser Phe Lys Asp Gln Val Leu Val Ser Cys Asp Thr 
                325                 330                 335     


Gly Tyr Lys Val Leu Lys Asp Asn Glu Val Met Asp Thr Phe Gln Ile 
            340                 345                 350         


Glu Cys Leu Lys Asp Gly Ala Trp Ser Asn Lys Ile Pro Thr Cys Lys 
        355                 360                 365             


Lys Ser Glu Ile Glu Leu Glu Lys Glu Leu Glu Ser Glu Pro Val Ala 
    370                 375                 380                 


Glu 
385 


<210>  14
<211>  660
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MAp44-mCR2

<400>  14

Met Arg Phe Leu Ser Phe Trp Arg Leu Leu Leu Tyr His Ala Leu Cys 
1               5                   10                  15      


Leu Ala Leu Pro Glu Val Ser Ala His Thr Val Glu Leu Asn Glu Met 
            20                  25                  30          


Phe Gly Gln Ile Gln Ser Pro Gly Tyr Pro Asp Ser Tyr Pro Ser Asp 
        35                  40                  45              


Ser Glu Val Thr Trp Asn Ile Thr Val Pro Glu Gly Phe Arg Ile Lys 
    50                  55                  60                  


Leu Tyr Phe Met His Phe Asn Leu Glu Ser Ser Tyr Leu Cys Glu Tyr 
65                  70                  75                  80  


Asp Tyr Val Lys Val Glu Thr Glu Asp Gln Val Leu Ala Thr Phe Cys 
                85                  90                  95      


Gly Arg Glu Thr Thr Asp Thr Glu Gln Thr Pro Gly Gln Glu Val Val 
            100                 105                 110         


Leu Ser Pro Gly Thr Phe Met Ser Val Thr Phe Arg Ser Asp Phe Ser 
        115                 120                 125             


Asn Glu Glu Arg Phe Thr Gly Phe Asp Ala His Tyr Met Ala Val Asp 
    130                 135                 140                 


Val Asp Glu Cys Lys Glu Arg Glu Asp Glu Glu Leu Ser Cys Asp His 
145                 150                 155                 160 


Tyr Cys His Asn Tyr Ile Gly Gly Tyr Tyr Cys Ser Cys Arg Phe Gly 
                165                 170                 175     


Tyr Ile Leu His Thr Asp Asn Arg Thr Cys Arg Val Glu Cys Ser Gly 
            180                 185                 190         


Asn Leu Phe Thr Gln Arg Thr Gly Thr Ile Thr Ser Pro Asp Tyr Pro 
        195                 200                 205             


Asn Pro Tyr Pro Lys Ser Ser Glu Cys Ser Tyr Thr Ile Asp Leu Glu 
    210                 215                 220                 


Glu Gly Phe Met Val Ser Leu Gln Phe Glu Asp Ile Phe Asp Ile Glu 
225                 230                 235                 240 


Asp His Pro Glu Val Pro Cys Pro Tyr Asp Tyr Ile Lys Ile Lys Ala 
                245                 250                 255     


Gly Ser Lys Val Trp Gly Pro Phe Cys Gly Glu Lys Ser Pro Glu Pro 
            260                 265                 270         


Ile Ser Thr Gln Thr His Ser Val Gln Ile Leu Phe Arg Ser Asp Asn 
        275                 280                 285             


Ser Gly Glu Asn Arg Gly Trp Arg Leu Ser Tyr Arg Ala Ala Gly Asn 
    290                 295                 300                 


Glu Cys Pro Lys Leu Gln Pro Pro Val Tyr Gly Lys Ile Glu Pro Ser 
305                 310                 315                 320 


Gln Ala Val Tyr Ser Phe Lys Asp Gln Val Leu Val Ser Cys Asp Thr 
                325                 330                 335     


Gly Tyr Lys Val Leu Lys Asp Asn Glu Val Met Asp Thr Phe Gln Ile 
            340                 345                 350         


Glu Cys Leu Lys Asp Gly Ala Trp Ser Asn Lys Ile Pro Thr Cys Lys 
        355                 360                 365             


Lys Ser Glu Ile Glu Leu Glu Lys Glu Leu Glu Ser Glu Pro Val Ala 
    370                 375                 380                 


Glu Gly Gly Gly Gly Ser Gly Gly Gly Gly Ile Ser Cys Asp Pro Pro 
385                 390                 395                 400 


Pro Glu Val Lys Asn Ala Arg Lys Pro Tyr Tyr Ser Leu Pro Ile Val 
                405                 410                 415     


Pro Gly Thr Val Leu Arg Tyr Thr Cys Ser Pro Ser Tyr Arg Leu Ile 
            420                 425                 430         


Gly Glu Lys Ala Ile Phe Cys Ile Ser Glu Asn Gln Val His Ala Thr 
        435                 440                 445             


Trp Asp Lys Ala Pro Pro Ile Cys Glu Ser Val Asn Lys Thr Ile Ser 
    450                 455                 460                 


Cys Ser Asp Pro Ile Val Pro Gly Gly Phe Met Asn Lys Gly Ser Lys 
465                 470                 475                 480 


Ala Pro Phe Arg His Gly Asp Ser Val Thr Phe Thr Cys Lys Ala Asn 
                485                 490                 495     


Phe Thr Met Lys Gly Ser Lys Thr Val Trp Cys Gln Ala Asn Glu Met 
            500                 505                 510         


Trp Gly Pro Thr Ala Leu Pro Val Cys Glu Ser Asp Phe Pro Leu Glu 
        515                 520                 525             


Cys Pro Ser Leu Pro Thr Ile His Asn Gly His His Thr Gly Gln His 
    530                 535                 540                 


Val Asp Gln Phe Val Ala Gly Leu Ser Val Thr Tyr Ser Cys Glu Pro 
545                 550                 555                 560 


Gly Tyr Leu Leu Thr Gly Lys Lys Thr Ile Lys Cys Leu Ser Ser Gly 
                565                 570                 575     


Asp Trp Asp Gly Val Ile Pro Thr Cys Lys Glu Ala Gln Cys Glu His 
            580                 585                 590         


Pro Gly Lys Phe Pro Asn Gly Gln Val Lys Glu Pro Leu Ser Leu Gln 
        595                 600                 605             


Val Gly Thr Thr Val Tyr Phe Ser Cys Asn Glu Gly Tyr Gln Leu Gln 
    610                 615                 620                 


Gly Gln Pro Ser Ser Gln Cys Val Ile Val Glu Gln Lys Ala Ile Trp 
625                 630                 635                 640 


Thr Lys Lys Pro Val Cys Lys Glu Ile Leu Ile Glu Gly Arg His His 
                645                 650                 655     


His His His His 
            660 


<210>  15
<211>  1827
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Mouse CR2-Crry nucleic acid sequence

<400>  15
atgcccatgg ggtctctgca accgctggcc accttgtacc tgctggggat gctggtcgct       60

tccgtgctag cgatttcttg tgaccctcct cctgaagtca aaaatgctcg gaaaccctat      120

tattctcttc ccatagttcc tggaactgtt ctgaggtaca cttgttcacc tagctaccgc      180

ctcattggag aaaaggctat cttttgtata agtgaaaatc aagtgcatgc cacctgggat      240

aaagctcctc ctatatgtga atctgtgaat aaaaccattt cttgctcaga tcccatagta      300

ccagggggat tcatgaataa aggatctaag gcaccattca gacatggtga ttctgtgaca      360

tttacctgta aagccaactt caccatgaaa ggaagcaaaa ctgtctggtg ccaggcaaat      420

gaaatgtggg gaccaacagc tctgccagtc tgtgagagtg atttccctct ggagtgccca      480

tcacttccaa cgattcataa tggacaccac acaggacagc atgttgacca gtttgttgcg      540

gggttgtctg tgacatacag ttgtgaacct ggctatttgc tcactggaaa aaagacaatt      600

aagtgcttat cttcaggaga ctgggatggt gtcatcccga catgcaaaga ggcccagtgt      660

gaacatccag gaaagtttcc caatgggcag gtaaaggaac ctctgagcct tcaggttggc      720

acaactgtgt acttctcctg taatgaaggg taccaattac aaggacaacc ctctagtcag      780

tgtgtaattg ttgaacagaa agccatctgg actaagaagc cagtatgtaa agaaattctc      840

ggcggaggtg ggtcgggtgg cggcggatct tgcccagccc catcacagct tccttctgcc      900

aaacctataa atctaactga tgaatccatg tttcccattg gaacatattt gttgtatgaa      960

tgtctcccag gatatatcaa gaggcagttc tctatcacct gcaaacaaga ctcaacctgg     1020

acgagtgctg aagataagtg tatacgaaaa caatgtaaaa ctccttcaga tcctgagaat     1080

ggcttggtac atgtacacac aggcattcag tttggatccc gtattaatta tacttgtaat     1140

caaggatacc gcctcattgg ttcctcctct gctgtatgtg tcatcactga tcaaagtgtt     1200

gattgggata ctgaggcacc tatttgtgag tggattcctt gtgagatacc cccaggcatt     1260

cccaatggag atttcttcag ttcaaccaga gaagactttc attatggaat ggtggttacc     1320

taccgctgca acactgatgc gagagggaag gcgctcttta acctggtggg tgagccctcc     1380

ttatactgta ccagcaacga tggtgaaatt ggagtctgga gcggccctcc tcctcagtgc     1440

attgaactca acaaatgtac tcctcctccc tatgttgaaa atgcagtcat gctgtctgag     1500

aacagaagct tgttttcctt aagggatatt gtggagttta gatgtcaccc tggctttatc     1560

atgaaaggag ccagcagtgt gcattgtcag tccctaaaca aatgggagcc agagttacca     1620

agctgcttca agggagtgat atgtcgtctc cctcaggaga tgagtggatt ccagaagggg     1680

ttgggaatga aaaaagaata ttattatgga gagaatgtaa ccttggaatg tgaggatggg     1740

tatactctag aaggcagttc tcaaagccag tgccagtctg atggcagctg gaatcctctt     1800

ctggccaaat gtgtatctcg ctcaatc                                         1827


<210>  16
<211>  609
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mouse CR2-Crry amino acid sequence

<400>  16

Met Pro Met Gly Ser Leu Gln Pro Leu Ala Thr Leu Tyr Leu Leu Gly 
1               5                   10                  15      


Met Leu Val Ala Ser Val Leu Ala Ile Ser Cys Asp Pro Pro Pro Glu 
            20                  25                  30          


Val Lys Asn Ala Arg Lys Pro Tyr Tyr Ser Leu Pro Ile Val Pro Gly 
        35                  40                  45              


Thr Val Leu Arg Tyr Thr Cys Ser Pro Ser Tyr Arg Leu Ile Gly Glu 
    50                  55                  60                  


Lys Ala Ile Phe Cys Ile Ser Glu Asn Gln Val His Ala Thr Trp Asp 
65                  70                  75                  80  


Lys Ala Pro Pro Ile Cys Glu Ser Val Asn Lys Thr Ile Ser Cys Ser 
                85                  90                  95      


Asp Pro Ile Val Pro Gly Gly Phe Met Asn Lys Gly Ser Lys Ala Pro 
            100                 105                 110         


Phe Arg His Gly Asp Ser Val Thr Phe Thr Cys Lys Ala Asn Phe Thr 
        115                 120                 125             


Met Lys Gly Ser Lys Thr Val Trp Cys Gln Ala Asn Glu Met Trp Gly 
    130                 135                 140                 


Pro Thr Ala Leu Pro Val Cys Glu Ser Asp Phe Pro Leu Glu Cys Pro 
145                 150                 155                 160 


Ser Leu Pro Thr Ile His Asn Gly His His Thr Gly Gln His Val Asp 
                165                 170                 175     


Gln Phe Val Ala Gly Leu Ser Val Thr Tyr Ser Cys Glu Pro Gly Tyr 
            180                 185                 190         


Leu Leu Thr Gly Lys Lys Thr Ile Lys Cys Leu Ser Ser Gly Asp Trp 
        195                 200                 205             


Asp Gly Val Ile Pro Thr Cys Lys Glu Ala Gln Cys Glu His Pro Gly 
    210                 215                 220                 


Lys Phe Pro Asn Gly Gln Val Lys Glu Pro Leu Ser Leu Gln Val Gly 
225                 230                 235                 240 


Thr Thr Val Tyr Phe Ser Cys Asn Glu Gly Tyr Gln Leu Gln Gly Gln 
                245                 250                 255     


Pro Ser Ser Gln Cys Val Ile Val Glu Gln Lys Ala Ile Trp Thr Lys 
            260                 265                 270         


Lys Pro Val Cys Lys Glu Ile Leu Gly Gly Gly Gly Ser Gly Gly Gly 
        275                 280                 285             


Gly Ser Cys Pro Ala Pro Ser Gln Leu Pro Ser Ala Lys Pro Ile Asn 
    290                 295                 300                 


Leu Thr Asp Glu Ser Met Phe Pro Ile Gly Thr Tyr Leu Leu Tyr Glu 
305                 310                 315                 320 


Cys Leu Pro Gly Tyr Ile Lys Arg Gln Phe Ser Ile Thr Cys Lys Gln 
                325                 330                 335     


Asp Ser Thr Trp Thr Ser Ala Glu Asp Lys Cys Ile Arg Lys Gln Cys 
            340                 345                 350         


Lys Thr Pro Ser Asp Pro Glu Asn Gly Leu Val His Val His Thr Gly 
        355                 360                 365             


Ile Gln Phe Gly Ser Arg Ile Asn Tyr Thr Cys Asn Gln Gly Tyr Arg 
    370                 375                 380                 


Leu Ile Gly Ser Ser Ser Ala Val Cys Val Ile Thr Asp Gln Ser Val 
385                 390                 395                 400 


Asp Trp Asp Thr Glu Ala Pro Ile Cys Glu Trp Ile Pro Cys Glu Ile 
                405                 410                 415     


Pro Pro Gly Ile Pro Asn Gly Asp Phe Phe Ser Ser Thr Arg Glu Asp 
            420                 425                 430         


Phe His Tyr Gly Met Val Val Thr Tyr Arg Cys Asn Thr Asp Ala Arg 
        435                 440                 445             


Gly Lys Ala Leu Phe Asn Leu Val Gly Glu Pro Ser Leu Tyr Cys Thr 
    450                 455                 460                 


Ser Asn Asp Gly Glu Ile Gly Val Trp Ser Gly Pro Pro Pro Gln Cys 
465                 470                 475                 480 


Ile Glu Leu Asn Lys Cys Thr Pro Pro Pro Tyr Val Glu Asn Ala Val 
                485                 490                 495     


Met Leu Ser Glu Asn Arg Ser Leu Phe Ser Leu Arg Asp Ile Val Glu 
            500                 505                 510         


Phe Arg Cys His Pro Gly Phe Ile Met Lys Gly Ala Ser Ser Val His 
        515                 520                 525             


Cys Gln Ser Leu Asn Lys Trp Glu Pro Glu Leu Pro Ser Cys Phe Lys 
    530                 535                 540                 


Gly Val Ile Cys Arg Leu Pro Gln Glu Met Ser Gly Phe Gln Lys Gly 
545                 550                 555                 560 


Leu Gly Met Lys Lys Glu Tyr Tyr Tyr Gly Glu Asn Val Thr Leu Glu 
                565                 570                 575     


Cys Glu Asp Gly Tyr Thr Leu Glu Gly Ser Ser Gln Ser Gln Cys Gln 
            580                 585                 590         


Ser Asp Gly Ser Trp Asn Pro Leu Leu Ala Lys Cys Val Ser Arg Ser 
        595                 600                 605             


Ile 
    


<210>  17
<211>  570
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Amino acid sequence of human CR2-FH


<220>
<221>  misc_feature
<222>  (197)..(197)
<223>  Xaa can be any naturally occurring amino acid

<400>  17

Ile Ser Cys Gly Ser Pro Pro Pro Ile Leu Asn Gly Arg Ile Ser Tyr 
1               5                   10                  15      


Tyr Ser Thr Pro Ile Ala Val Gly Thr Val Ile Arg Tyr Ser Cys Ser 
            20                  25                  30          


Gly Thr Phe Arg Leu Ile Gly Glu Lys Ser Leu Leu Cys Ile Thr Lys 
        35                  40                  45              


Asp Lys Val Asp Gly Thr Trp Asp Lys Pro Ala Pro Lys Cys Glu Tyr 
    50                  55                  60                  


Phe Asn Lys Tyr Ser Ser Cys Pro Glu Pro Ile Val Pro Gly Gly Tyr 
65                  70                  75                  80  


Lys Ile Arg Gly Ser Thr Pro Tyr Arg His Gly Asp Ser Val Thr Phe 
                85                  90                  95      


Ala Cys Lys Thr Asn Phe Ser Met Asn Gly Asn Lys Ser Val Trp Cys 
            100                 105                 110         


Gln Ala Asn Asn Ile Asn Asn Met Trp Gly Pro Thr Arg Leu Pro Thr 
        115                 120                 125             


Cys Val Ser Val Phe Pro Leu Glu Cys Pro Ala Leu Pro Met Ile His 
    130                 135                 140                 


Asn Gly His His Thr Ser Glu Asn Val Gly Ser Ile Ala Pro Gly Leu 
145                 150                 155                 160 


Ser Val Thr Tyr Ser Cys Glu Ser Gly Tyr Leu Leu Val Gly Glu Lys 
                165                 170                 175     


Ile Ile Asn Cys Leu Ser Ser Gly Lys Trp Ser Ala Val Pro Pro Thr 
            180                 185                 190         


Cys Glu Glu Ala Xaa Cys Lys Ser Leu Gly Arg Phe Pro Asn Gly Lys 
        195                 200                 205             


Val Lys Glu Pro Pro Ile Leu Arg Val Gly Val Thr Ala Asn Phe Phe 
    210                 215                 220                 


Cys Asp Glu Gly Tyr Arg Leu Gln Gly Pro Pro Ser Ser Arg Cys Val 
225                 230                 235                 240 


Ile Ala Gly Gln Gly Val Ala Trp Thr Lys Met Pro Val Cys Gly Gly 
                245                 250                 255     


Gly Gly Ser Gly Gly Gly Gly Ser Cys Val Ala Glu Asp Cys Asn Glu 
            260                 265                 270         


Leu Pro Pro Arg Arg Asn Thr Glu Ile Leu Thr Gly Ser Trp Ser Asp 
        275                 280                 285             


Gln Thr Tyr Pro Glu Gly Thr Gln Ala Ile Tyr Lys Cys Arg Pro Gly 
    290                 295                 300                 


Tyr Arg Ser Leu Gly Asn Val Ile Met Val Cys Arg Lys Gly Glu Trp 
305                 310                 315                 320 


Val Ala Leu Asn Pro Leu Arg Lys Cys Gln Lys Arg Pro Cys Gly His 
                325                 330                 335     


Pro Gly Asp Thr Pro Phe Gly Thr Phe Thr Leu Thr Gly Gly Asn Val 
            340                 345                 350         


Phe Glu Tyr Gly Val Lys Ala Val Tyr Thr Cys Asn Glu Gly Tyr Gln 
        355                 360                 365             


Leu Leu Gly Glu Ile Asn Tyr Arg Glu Cys Asp Thr Asp Gly Trp Thr 
    370                 375                 380                 


Asn Asp Ile Pro Ile Cys Glu Val Val Lys Cys Leu Pro Val Thr Ala 
385                 390                 395                 400 


Pro Glu Asn Gly Lys Ile Val Ser Ser Ala Met Glu Pro Asp Arg Glu 
                405                 410                 415     


Tyr His Phe Gly Gln Ala Val Arg Phe Val Cys Asn Ser Gly Tyr Lys 
            420                 425                 430         


Ile Glu Gly Asp Glu Glu Met His Cys Ser Asp Asp Gly Phe Trp Ser 
        435                 440                 445             


Lys Glu Lys Pro Lys Cys Val Glu Ile Ser Cys Lys Ser Pro Asp Val 
    450                 455                 460                 


Ile Asn Gly Ser Pro Ile Ser Gln Lys Ile Ile Tyr Lys Glu Asn Glu 
465                 470                 475                 480 


Arg Phe Gln Tyr Lys Cys Asn Met Gly Tyr Glu Tyr Ser Glu Arg Gly 
                485                 490                 495     


Asp Ala Val Cys Thr Glu Ser Gly Trp Arg Pro Leu Pro Ser Cys Glu 
            500                 505                 510         


Glu Lys Ser Cys Asp Asn Pro Tyr Ile Pro Asn Gly Asp Tyr Ser Pro 
        515                 520                 525             


Leu Arg Ile Lys His Arg Thr Gly Asp Glu Ile Thr Tyr Gln Cys Arg 
    530                 535                 540                 


Asn Gly Phe Tyr Pro Ala Thr Arg Gly Asn Thr Ala Lys Cys Thr Ser 
545                 550                 555                 560 


Thr Gly Trp Ile Pro Ala Pro Arg Cys Thr 
                565                 570 


<210>  18
<211>  559
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Amino acid sequence Mouse CR2-FH

<400>  18

Ile Ser Cys Asp Pro Pro Pro Glu Val Lys Asn Ala Arg Lys Pro Tyr 
1               5                   10                  15      


Tyr Ser Leu Pro Ile Val Pro Gly Thr Val Leu Arg Tyr Thr Cys Ser 
            20                  25                  30          


Pro Ser Tyr Arg Leu Ile Gly Glu Lys Ala Ile Phe Cys Ile Ser Glu 
        35                  40                  45              


Asn Gln Val His Ala Thr Trp Asp Lys Ala Pro Pro Ile Cys Glu Ser 
    50                  55                  60                  


Val Asn Lys Thr Ile Ser Cys Ser Asp Pro Ile Val Pro Gly Gly Phe 
65                  70                  75                  80  


Met Asn Lys Gly Ser Lys Ala Pro Phe Arg His Gly Asp Ser Val Thr 
                85                  90                  95      


Phe Thr Cys Lys Ala Asn Phe Thr Met Lys Gly Ser Lys Thr Val Trp 
            100                 105                 110         


Cys Gln Ala Asn Glu Met Trp Gly Pro Thr Ala Leu Pro Val Cys Glu 
        115                 120                 125             


Ser Asp Phe Pro Leu Glu Cys Pro Ser Leu Pro Thr Ile His Asn Gly 
    130                 135                 140                 


His His Thr Gly Gln His Val Asp Gln Phe Val Ala Gly Leu Ser Val 
145                 150                 155                 160 


Thr Tyr Ser Cys Glu Pro Gly Tyr Leu Leu Thr Gly Lys Lys Thr Ile 
                165                 170                 175     


Lys Cys Leu Ser Ser Gly Asp Trp Asp Gly Val Ile Pro Thr Cys Lys 
            180                 185                 190         


Glu Ala Gln Cys Glu His Pro Gly Lys Phe Pro Asn Gly Gln Val Lys 
        195                 200                 205             


Glu Pro Leu Ser Leu Gln Val Gly Thr Thr Val Tyr Phe Ser Cys Asn 
    210                 215                 220                 


Glu Gly Tyr Gln Leu Gln Gly Gln Pro Ser Ser Gln Cys Val Ile Val 
225                 230                 235                 240 


Glu Gln Lys Ala Ile Val Thr Lys Lys Pro Val Cys Lys Glu Ile Leu 
                245                 250                 255     


Glu Asp Cys Lys Gly Pro Pro Pro Arg Glu Asn Ser Glu Ile Leu Ser 
            260                 265                 270         


Gly Ser Trp Ser Glu Gln Leu Tyr Pro Glu Gly Thr Gln Ala Thr Tyr 
        275                 280                 285             


Lys Cys Arg Pro Gly Tyr Arg Thr Leu Gly Thr Ile Val Lys Val Cys 
    290                 295                 300                 


Lys Asn Gly Lys Trp Val Ala Ser Asn Pro Ser Arg Ile Cys Arg Lys 
305                 310                 315                 320 


Lys Pro Cys Gly His Pro Gly Asp Thr Pro Phe Gly Ser Phe Arg Leu 
                325                 330                 335     


Ala Val Gly Ser Gln Phe Glu Phe Gly Ala Lys Val Val Tyr Thr Cys 
            340                 345                 350         


Asp Asp Gly Tyr Gln Leu Leu Gly Glu Ile Asp Tyr Arg Glu Cys Gly 
        355                 360                 365             


Ala Asp Gly Trp Ile Asn Asp Ile Pro Leu Cys Glu Val Val Lys Cys 
    370                 375                 380                 


Leu Pro Val Thr Glu Leu Glu Asn Gly Arg Ile Val Ser Gly Ala Ala 
385                 390                 395                 400 


Glu Thr Asp Gln Glu Tyr Tyr Phe Gly Gln Val Val Arg Phe Glu Cys 
                405                 410                 415     


Asn Ser Gly Phe Lys Ile Glu Gly His Lys Glu Ile His Cys Ser Glu 
            420                 425                 430         


Asn Gly Leu Trp Ser Asn Glu Lys Pro Arg Cys Val Glu Ile Leu Cys 
        435                 440                 445             


Thr Pro Pro Arg Val Glu Asn Gly Asp Gly Ile Asn Val Lys Pro Val 
    450                 455                 460                 


Tyr Lys Glu Asn Glu Arg Tyr His Tyr Lys Cys Lys His Gly Tyr Val 
465                 470                 475                 480 


Pro Lys Glu Arg Gly Asp Ala Val Cys Thr Gly Ser Gly Trp Ser Ser 
                485                 490                 495     


Gln Pro Phe Cys Glu Glu Lys Arg Cys Ser Pro Pro Tyr Ile Leu Asn 
            500                 505                 510         


Gly Ile Tyr Thr Pro His Arg Ile Ile His Arg Ser Asp Asp Glu Ile 
        515                 520                 525             


Arg Tyr Glu Cys Asn Tyr Gly Phe Tyr Pro Val Thr Gly Ser Thr Val 
    530                 535                 540                 


Ser Lys Cys Thr Pro Thr Gly Trp Ile Pro Val Pro Arg Cys Thr 
545                 550                 555                 


