                         SEQUENCE LISTING

<110>  APELLIS PHARMACEUTICALS, INC.
 
<120>  COMBINATION THERAPY FOR C3 INHIBITION

<130>  2008575-0262

<140>  PCT/US17/56708
<141>  2017-10-16

<150>  62/409,357
<151>  2016-10-17

<160>  272   

<170>  PatentIn version 3.5

<210>  1
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic peptide


<220>
<221>  misc_feature
<222>  (2)..(12)
<223>  Disulfide bond

<400>  1

Ile Cys Val Val Gln Asp Trp Gly His His Arg Cys Thr 
1               5                   10              


<210>  2
<211>  42
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polypeptide


<220>
<221>  MOD_RES
<222>  (1)..(19)
<223>  Any independently selected amino acid or amino acid analog

<220>
<221>  misc_feature
<222>  (1)..(19)
<223>  This region may encompass 2 to 19 residues, wherein some residues
       may be absent

<220>
<221>  MOD_RES
<222>  (22)..(22)
<223>  Trp or an analog of Trp

<220>
<221>  MOD_RES
<222>  (24)..(42)
<223>  Any independently selected amino acid or amino acid analog

<220>
<221>  misc_feature
<222>  (24)..(42)
<223>  This region may encompass 2 to 19 residues, wherein some residues
       may be absent

<400>  2

Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
1               5                   10                  15      


Xaa Xaa Xaa Gln Asp Xaa Gly Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
            20                  25                  30          


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
        35                  40          


<210>  3
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic peptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Trp or an analog of Trp

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  Trp or an analog of Trp

<400>  3

Xaa Gln Asp Xaa Gly 
1               5   


<210>  4
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic peptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Trp or an analog of Trp

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  Trp or an analog of Trp

<220>
<221>  MOD_RES
<222>  (6)..(6)
<223>  His, Ala, analogs of Ala, Phe or Trp

<400>  4

Xaa Gln Asp Xaa Gly Xaa 
1               5       


<210>  5
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic peptide


<220>
<221>  MOD_RES
<222>  (1)..(3)
<223>  Any independently selected amino acid or amino acid analog

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  Trp or analog of Trp

<220>
<221>  MOD_RES
<222>  (7)..(7)
<223>  Trp or analog of Trp

<220>
<221>  MOD_RES
<222>  (9)..(13)
<223>  Any independently selected amino acid or amino acid analog

<400>  5

Xaa Xaa Xaa Xaa Gln Asp Xaa Gly Xaa Xaa Xaa Xaa Xaa 
1               5                   10              


<210>  6
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic peptide


<220>
<221>  MOD_RES
<222>  (1)..(2)
<223>  Ile, Val, Leu, B1-Ile, B1-Val, B1-Leu or a dipeptide comprising 
       Gly-Ile or B1-Gly-Ile, wherein B1 represents a first blocking 
       moiety

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  This region encompasses 1 to 2 residues (up to one position out 
       of two may be absent)

<220>
<221>  misc_feature
<222>  (3)..(13)
<223>  Disulfide bond

<220>
<221>  MOD_RES
<222>  (5)..(5)
<223>  Independently selected from Trp or analogs of Trp

<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  Independently selected from Trp or analogs of Trp

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  His, Ala or an analog of Ala, Phe, Trp or an analog of Trp

<220>
<221>  MOD_RES
<222>  (14)..(16)
<223>  L-Thr, D-Thr, Ile, Val, Gly, a dipeptide selected from Thr-Ala or
       Thr-Asn, or a tripeptide comprising Thr-Ala-Asn, wherein a c-term
       -OH of any of the L-Thr, D-Thr, Ile, Val, Gly, Ala or Asn is 
       optionally replaced by a second blocking moiety

<220>
<221>  misc_feature
<222>  (14)..(16)
<223>  This region encompasses 1 to 3 residues (up to two positions out 
       of three may be absent)

<400>  6

Xaa Xaa Cys Val Xaa Gln Asp Xaa Gly Xaa His Arg Cys Xaa Xaa Xaa 
1               5                   10                  15      


<210>  7
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic peptide


<220>
<221>  MOD_RES
<222>  (1)..(2)
<223>  Ile, Val, Leu, Ac-Ile, Ac-Val, Ac-Leu or a dipeptide comprising 
       Gly-Ile or Ac-Gly-Ile

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  This region encompasses 1 to 2 residues (up to one position out 
       of two may be absent)

<220>
<221>  misc_feature
<222>  (3)..(13)
<223>  Disulfide bond

<220>
<221>  MOD_RES
<222>  (5)..(5)
<223>  Independently selected from Trp or analogs of Trp

<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  Independently selected from Trp or analogs of Trp

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  His, Ala or an analog of Ala, Phe, Trp or an analog of Trp

<220>
<221>  MOD_RES
<222>  (14)..(16)
<223>  L-Thr, D-Thr, Ile, Val, Gly, a dipeptide selected from Thr-Ala or
       Thr-Asn, or a tripeptide comprising Thr-Ala-Asn, wherein a c-term
       -OH of any of L-Thr, D-Thr, Ile, Val, Gly, Ala, or Asn is 
       optionally replaced by -NH2

<220>
<221>  misc_feature
<222>  (14)..(16)
<223>  This region encompasses 1 to 3 residues (up to two positions out 
       of three may be absent)

<400>  7

Xaa Xaa Cys Val Xaa Gln Asp Xaa Gly Xaa His Arg Cys Xaa Xaa Xaa 
1               5                   10                  15      


<210>  8
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic peptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  N-term H

<220>
<221>  MOD_RES
<222>  (13)..(13)
<223>  C-term CONH2

<400>  8

Ile Cys Val Val Gln Asp Trp Gly His His Arg Cys Thr 
1               5                   10              


<210>  9
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic peptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  N-term Ac

<220>
<221>  MOD_RES
<222>  (13)..(13)
<223>  C-term CONH2

<400>  9

Ile Cys Val Val Gln Asp Trp Gly His His Arg Cys Thr 
1               5                   10              


<210>  10
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic peptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  N-term Ac

<220>
<221>  MOD_RES
<222>  (13)..(13)
<223>  C-term CONH2

<400>  10

Ile Cys Val Tyr Gln Asp Trp Gly Ala His Arg Cys Thr 
1               5                   10              


<210>  11
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic peptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  N-term Ac

<220>
<221>  MOD_RES
<222>  (13)..(13)
<223>  C-term COOH

<400>  11

Ile Cys Val Trp Gln Asp Trp Gly Ala His Arg Cys Thr 
1               5                   10              


<210>  12
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic peptide


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  N-term Ac

<220>
<221>  MISC_FEATURE
<222>  (13)..(13)
<223>  C-term CONH2

<400>  12

Ile Cys Val Trp Gln Asp Trp Gly Ala His Arg Cys Thr 
1               5                   10              


<210>  13
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic peptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  N-term Ac

<220>
<221>  MOD_RES
<222>  (13)..(13)
<223>  d-Thr

<220>
<221>  MOD_RES
<222>  (13)..(13)
<223>  C-term COOH

<400>  13

Ile Cys Val Trp Gln Asp Trp Gly Ala His Arg Cys Thr 
1               5                   10              


<210>  14
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic peptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  N-term Ac

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  2-Nal

<220>
<221>  MOD_RES
<222>  (13)..(13)
<223>  C-term CONH2

<400>  14

Ile Cys Val Ala Gln Asp Trp Gly Ala His Arg Cys Thr 
1               5                   10              


<210>  15
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic peptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  N-term Ac

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  2-Nal

<220>
<221>  MOD_RES
<222>  (13)..(13)
<223>  C-term COOH

<400>  15

Ile Cys Val Ala Gln Asp Trp Gly Ala His Arg Cys Thr 
1               5                   10              


<210>  16
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic peptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  N-term Ac

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  1-Nal

<220>
<221>  MOD_RES
<222>  (13)..(13)
<223>  C-term COOH

<400>  16

Ile Cys Val Ala Gln Asp Trp Gly Ala His Arg Cys Thr 
1               5                   10              


<210>  17
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic peptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  N-term Ac

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  2-Igl

<220>
<221>  MOD_RES
<222>  (13)..(13)
<223>  C-term CONH2

<400>  17

Ile Cys Val Gly Gln Asp Trp Gly Ala His Arg Cys Thr 
1               5                   10              


<210>  18
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic peptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  N-term Ac

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  2-Igl

<220>
<221>  MOD_RES
<222>  (13)..(13)
<223>  C-term COOH

<400>  18

Ile Cys Val Gly Gln Asp Trp Gly Ala His Arg Cys Thr 
1               5                   10              


<210>  19
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic peptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  N-term Ac

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  Dht

<220>
<221>  MOD_RES
<222>  (13)..(13)
<223>  C-term COOH

<400>  19

Ile Cys Val Trp Gln Asp Trp Gly Ala His Arg Cys Thr 
1               5                   10              


<210>  20
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic peptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  N-term Ac

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  Bpa

<220>
<221>  MOD_RES
<222>  (13)..(13)
<223>  C-term COOH

<400>  20

Ile Cys Val Phe Gln Asp Trp Gly Ala His Arg Cys Thr 
1               5                   10              


<210>  21
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic peptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  N-term Ac

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  Bpa

<220>
<221>  MOD_RES
<222>  (13)..(13)
<223>  C-term CONH2

<400>  21

Ile Cys Val Phe Gln Asp Trp Gly Ala His Arg Cys Thr 
1               5                   10              


<210>  22
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic peptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  N-term Ac

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  Bta (beta-3-benzothienyl-L-alanine)

<220>
<221>  MOD_RES
<222>  (13)..(13)
<223>  C-term COOH

<400>  22

Ile Cys Val Xaa Gln Asp Trp Gly Ala His Arg Cys Thr 
1               5                   10              


<210>  23
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic peptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  N-term Ac

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  Bta (beta-3-benzothienyl-L-alanine)

<220>
<221>  MOD_RES
<222>  (13)..(13)
<223>  C-term CONH2

<400>  23

Ile Cys Val Xaa Gln Asp Trp Gly Ala His Arg Cys Thr 
1               5                   10              


<210>  24
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic peptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  N-term Ac

<220>
<221>  MOD_RES
<222>  (9)..(9)
<223>  2-Abu

<220>
<221>  MOD_RES
<222>  (13)..(13)
<223>  C-term CONH2

<400>  24

Ile Cys Val Trp Gln Asp Trp Gly Xaa His Arg Cys Thr 
1               5                   10              


<210>  25
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic peptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  N-term H

<220>
<221>  MOD_RES
<222>  (16)..(16)
<223>  C-term COOH

<400>  25

Gly Ile Cys Val Trp Gln Asp Trp Gly Ala His Arg Cys Thr Ala Asn 
1               5                   10                  15      


<210>  26
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic peptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  N-term Ac

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  5f-Trp

<220>
<221>  MOD_RES
<222>  (13)..(13)
<223>  C-term CONH2

<400>  26

Ile Cys Val Trp Gln Asp Trp Gly Ala His Arg Cys Thr 
1               5                   10              


<210>  27
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic peptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  N-term Ac

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  5-methyl-Trp

<220>
<221>  MOD_RES
<222>  (13)..(13)
<223>  C-term CONH2

<400>  27

Ile Cys Val Trp Gln Asp Trp Gly Ala His Arg Cys Thr 
1               5                   10              


<210>  28
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic peptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  N-term Ac

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  1-methyl-Trp

<220>
<221>  MOD_RES
<222>  (13)..(13)
<223>  C-term CONH2

<400>  28

Ile Cys Val Trp Gln Asp Trp Gly Ala His Arg Cys Thr 
1               5                   10              


<210>  29
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic peptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  N-term Ac

<220>
<221>  MOD_RES
<222>  (7)..(7)
<223>  5f-Trp

<220>
<221>  MOD_RES
<222>  (13)..(13)
<223>  C-term CONH2

<400>  29

Ile Cys Val Trp Gln Asp Trp Gly Ala His Arg Cys Thr 
1               5                   10              


<210>  30
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic peptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  N-term Ac

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  5f-Trp

<220>
<221>  MOD_RES
<222>  (7)..(7)
<223>  5f-Trp

<220>
<221>  MOD_RES
<222>  (13)..(13)
<223>  C-term CONH2

<400>  30

Ile Cys Val Trp Gln Asp Trp Gly Ala His Arg Cys Thr 
1               5                   10              


<210>  31
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic peptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  N-term Ac

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  5-methyl-Trp

<220>
<221>  MOD_RES
<222>  (7)..(7)
<223>  5f-Trp

<220>
<221>  MOD_RES
<222>  (13)..(13)
<223>  C-term CONH2

<400>  31

Ile Cys Val Trp Gln Asp Trp Gly Ala His Arg Cys Thr 
1               5                   10              


<210>  32
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic peptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  N-term Ac

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  1-methyl-Trp

<220>
<221>  MOD_RES
<222>  (7)..(7)
<223>  5f-Trp

<220>
<221>  MOD_RES
<222>  (13)..(13)
<223>  C-term CONH2

<400>  32

Ile Cys Val Trp Gln Asp Trp Gly Ala His Arg Cys Thr 
1               5                   10              


<210>  33
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic peptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  N-term H

<220>
<221>  MOD_RES
<222>  (5)..(5)
<223>  6f-Trp

<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  6f-Trp

<220>
<221>  MOD_RES
<222>  (15)..(15)
<223>  C-term COOH

<400>  33

Gly Ile Cys Val Trp Gln Asp Trp Gly Ala His Arg Cys Thr Asn 
1               5                   10                  15  


<210>  34
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic peptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  N-term Ac

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  1-formyl-Trp

<220>
<221>  MOD_RES
<222>  (13)..(13)
<223>  C-term CONH2

<400>  34

Ile Cys Val Trp Gln Asp Trp Gly Ala His Arg Cys Thr 
1               5                   10              


<210>  35
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic peptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  N-term Ac

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  1-methoxy-Trp

<220>
<221>  MOD_RES
<222>  (13)..(13)
<223>  C-term CONH2

<400>  35

Ile Cys Val Trp Gln Asp Trp Gly Ala His Arg Cys Thr 
1               5                   10              


<210>  36
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic peptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  N-term H

<220>
<221>  MOD_RES
<222>  (5)..(5)
<223>  5f-Trp

<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  5f-Trp

<220>
<221>  MOD_RES
<222>  (15)..(15)
<223>  C-term COOH

<400>  36

Gly Ile Cys Val Trp Gln Asp Trp Gly Ala His Arg Cys Thr Asn 
1               5                   10                  15  


<210>  37
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic peptide


<220>
<221>  misc_feature
<222>  (2)..(12)
<223>  Disulfide bond

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  (1Me)Trp

<400>  37

Ile Cys Val Trp Gln Asp Trp Gly Ala His Arg Cys Thr 
1               5                   10              


<210>  38
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic peptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  N-term Maleimide-(CH2)5-C(=O)

<220>
<221>  misc_feature
<222>  (2)..(12)
<223>  Disulfide bond

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  (1Me)Trp

<220>
<221>  MOD_RES
<222>  (13)..(13)
<223>  C-term NH2

<400>  38

Ile Cys Val Trp Gln Asp Trp Gly Ala His Arg Cys Thr 
1               5                   10              


<210>  39
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic peptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  N-term Ac

<220>
<221>  misc_feature
<222>  (2)..(12)
<223>  Disulfide bond

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  (1Me)Trp

<220>
<221>  MOD_RES
<222>  (13)..(13)
<223>  C-term (C=O)-(CH2)5-maleimide

<400>  39

Ile Cys Val Trp Gln Asp Trp Gly Ala His Arg Cys Thr 
1               5                   10              


<210>  40
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic peptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  N-term Maleimide-(CH2)2-C(=O)-NH-CH2CH2OCH2CH2O CH2CH2C(=O)

<220>
<221>  misc_feature
<222>  (2)..(12)
<223>  Disulfide bond

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  (1Me)Trp

<220>
<221>  MOD_RES
<222>  (13)..(13)
<223>  C-term NH2

<400>  40

Ile Cys Val Trp Gln Asp Trp Gly Ala His Arg Cys Thr 
1               5                   10              


<210>  41
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic peptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  N-term Maleimide-(CH2)2-C(=O)-NH-CH2CH2OCH2CH2C(=O)

<220>
<221>  misc_feature
<222>  (2)..(12)
<223>  Disulfide bond

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  (1Me)Trp

<220>
<221>  MOD_RES
<222>  (13)..(13)
<223>  C-term NH2

<400>  41

Ile Cys Val Trp Gln Asp Trp Gly Ala His Arg Cys Thr 
1               5                   10              


<210>  42
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic peptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  N-term Maleimide-(CH2)3-C(=O)-NH-CH2CH2OCH2CH2 OCH2C(=O)

<220>
<221>  misc_feature
<222>  (2)..(12)
<223>  Disulfide bond

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  (1Me)Trp

<220>
<221>  MOD_RES
<222>  (13)..(13)
<223>  C-term NH2

<400>  42

Ile Cys Val Trp Gln Asp Trp Gly Ala His Arg Cys Thr 
1               5                   10              


<210>  43
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic peptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  N-term Maleimide-(CH2)5-C(=O)-NH-CH2CH2OCH2CH2 OCH2C(=O)

<220>
<221>  misc_feature
<222>  (2)..(12)
<223>  Disulfide bond

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  (1Me)Trp

<220>
<221>  MOD_RES
<222>  (13)..(13)
<223>  C-term NH2

<400>  43

Ile Cys Val Trp Gln Asp Trp Gly Ala His Arg Cys Thr 
1               5                   10              


<210>  44
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic peptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  N-term Maleimide-(CH2)4-C(=O)-NH-CH2CH2OCH2CH2 OCH2CH2C(=O)

<220>
<221>  misc_feature
<222>  (2)..(12)
<223>  Disulfide bond

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  (1Me)Trp

<220>
<221>  MOD_RES
<222>  (13)..(13)
<223>  C-term NH2

<400>  44

Ile Cys Val Trp Gln Asp Trp Gly Ala His Arg Cys Thr 
1               5                   10              


<210>  45
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic peptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  N-term Maleimide-(CH2)2-C(=O)-NH-CH2CH2OCH2CH2 OCH2CH2C(=O)

<220>
<221>  misc_feature
<222>  (2)..(12)
<223>  Disulfide bond

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  (1Me)Trp

<220>
<221>  MOD_RES
<222>  (13)..(13)
<223>  C-term NH2

<400>  45

Ile Cys Val Trp Gln Asp Trp Gly Ala His Arg Cys Thr 
1               5                   10              


<210>  46
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic peptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  N-term Maleimide-(CH2)5-C(=O)-NH-CH2CH2OCH2CH2 OCH2C(=O)

<220>
<221>  misc_feature
<222>  (2)..(12)
<223>  Disulfide bond

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  (1Me)Trp

<220>
<221>  MOD_RES
<222>  (13)..(13)
<223>  C-term NH2

<400>  46

Ile Cys Val Trp Gln Asp Trp Gly Ala His Arg Cys Thr 
1               5                   10              


<210>  47
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic peptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  N-term Ac

<220>
<221>  misc_feature
<222>  (2)..(12)
<223>  Disulfide bond

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  (1Me)Trp

<220>
<221>  MOD_RES
<222>  (14)..(14)
<223>  C-term NH2

<400>  47

Ile Cys Val Trp Gln Asp Trp Gly Ala His Arg Cys Thr Lys 
1               5                   10                  


<210>  48
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic peptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  N-term Ac

<220>
<221>  misc_feature
<222>  (2)..(12)
<223>  Disulfide bond

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  (1Me)Trp

<220>
<221>  MOD_RES
<222>  (19)..(19)
<223>  C-term NH2

<400>  48

Ile Cys Val Trp Gln Asp Trp Gly Ala His Arg Cys Thr Gly Gly Gly 
1               5                   10                  15      


Gly Gly Lys 
            


<210>  49
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic peptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  N-term NH2(CH2)5C(=O)

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  (1Me)Trp

<220>
<221>  MOD_RES
<222>  (13)..(13)
<223>  C-term NH2

<400>  49

Ile Cys Val Trp Gln Asp Trp Gly Ala His Arg Cys Thr 
1               5                   10              


<210>  50
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic peptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  N-term NH2(CH2CH2O)2CH2C(=O)

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  (1Me)Trp

<220>
<221>  MOD_RES
<222>  (13)..(13)
<223>  C-term NH2

<400>  50

Ile Cys Val Trp Gln Asp Trp Gly Ala His Arg Cys Thr 
1               5                   10              


<210>  51
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic peptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  N-term Ac

<220>
<221>  misc_feature
<222>  (2)..(12)
<223>  Disulfide bond

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  (1Me)Trp

<220>
<221>  MOD_RES
<222>  (14)..(14)
<223>  NH-CH2CH2OCH2CH2OCH2-C(=O)-Lys

<220>
<221>  MOD_RES
<222>  (14)..(14)
<223>  C-term NH2

<400>  51

Ile Cys Val Trp Gln Asp Trp Gly Ala His Arg Cys Thr Lys 
1               5                   10                  


<210>  52
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic peptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  N-term Ac

<220>
<221>  misc_feature
<222>  (2)..(12)
<223>  Disulfide bond

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  (1Me)Trp

<220>
<221>  MOD_RES
<222>  (14)..(14)
<223>  Lys-(C(=O)-(CH2)5-Mal)

<220>
<221>  MOD_RES
<222>  (14)..(14)
<223>  C-term NH2

<400>  52

Ile Cys Val Trp Gln Asp Trp Gly Ala His Arg Cys Thr Lys 
1               5                   10                  


<210>  53
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic peptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  N-term Ac

<220>
<221>  misc_feature
<222>  (2)..(12)
<223>  Disulfide bond

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  (1Me)Trp

<220>
<221>  MOD_RES
<222>  (19)..(19)
<223>  Lys-(C(=O)-(CH2)5-Mal)

<220>
<221>  MOD_RES
<222>  (19)..(19)
<223>  C-term NH2

<400>  53

Ile Cys Val Trp Gln Asp Trp Gly Ala His Arg Cys Thr Gly Gly Gly 
1               5                   10                  15      


Gly Gly Lys 
            


<210>  54
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic peptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  N-term Mal-(CH2)5-(C(=O)-NH(CH2)5C(=O)

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  (1Me)Trp

<220>
<221>  MOD_RES
<222>  (13)..(13)
<223>  C-term NH2

<400>  54

Ile Cys Val Trp Gln Asp Trp Gly Ala His Arg Cys Thr 
1               5                   10              


<210>  55
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic peptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  N-term Mal-(CH2)5-(C(=O)NH(CH2CH2O)2CH2C(=O)

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  (1Me)Trp

<220>
<221>  MOD_RES
<222>  (13)..(13)
<223>  C-term NH2

<400>  55

Ile Cys Val Trp Gln Asp Trp Gly Ala His Arg Cys Thr 
1               5                   10              


<210>  56
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic peptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  N-term Ac

<220>
<221>  misc_feature
<222>  (2)..(12)
<223>  Disulfide bond

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  (1Me)Trp

<220>
<221>  MOD_RES
<222>  (14)..(14)
<223>  NH-CH2CH2OCH2CH2OCH2-C(=O)-Lys-(C(=O)-(CH2)5-Mal)

<220>
<221>  MOD_RES
<222>  (14)..(14)
<223>  C-term NH2

<400>  56

Ile Cys Val Trp Gln Asp Trp Gly Ala His Arg Cys Thr Lys 
1               5                   10                  


<210>  57
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic peptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  N-term Ac

<220>
<221>  misc_feature
<222>  (2)..(12)
<223>  Disulfide bond

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  (1Me)Trp

<220>
<221>  MOD_RES
<222>  (14)..(14)
<223>  Lys-C(=O)-CH2(OCH2CH2)2NH(C(=O)-(CH2)5-Mal)

<220>
<221>  MOD_RES
<222>  (14)..(14)
<223>  C-term NH2

<400>  57

Ile Cys Val Trp Gln Asp Trp Gly Ala His Arg Cys Thr Lys 
1               5                   10                  


<210>  58
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic peptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  N-term (CH2CH2O)nC(=O)

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  (1Me)Trp

<220>
<221>  MOD_RES
<222>  (13)..(13)
<223>  C-term NH2

<400>  58

Ile Cys Val Trp Gln Asp Trp Gly Ala His Arg Cys Thr 
1               5                   10              


<210>  59
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic peptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  N-term Ac

<220>
<221>  misc_feature
<222>  (2)..(12)
<223>  Disulfide bond

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  (1Me)Trp

<220>
<221>  MOD_RES
<222>  (14)..(14)
<223>  NH-CH2CH2OCH2CH2OCH2-C(=O)-Lys-C(=O)-(CH2CH2O)n

<220>
<221>  MOD_RES
<222>  (14)..(14)
<223>  C-term NH2

<400>  59

Ile Cys Val Trp Gln Asp Trp Gly Ala His Arg Cys Thr Lys 
1               5                   10                  


<210>  60
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic peptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  N-term Ac

<220>
<221>  misc_feature
<222>  (2)..(12)
<223>  Disulfide bond

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  (1Me)Trp

<220>
<221>  MOD_RES
<222>  (14)..(14)
<223>  Lys-C(=O)-(CH2CH2O)n

<220>
<221>  MOD_RES
<222>  (14)..(14)
<223>  C-term NH2

<400>  60

Ile Cys Val Trp Gln Asp Trp Gly Ala His Arg Cys Thr Lys 
1               5                   10                  


<210>  61
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic peptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  N-term Ac

<220>
<221>  misc_feature
<222>  (2)..(12)
<223>  Disulfide bond

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  (1Me)Trp

<220>
<221>  MOD_RES
<222>  (19)..(19)
<223>  Lys-C(=O)-(CH2CH2O)n

<220>
<221>  MOD_RES
<222>  (19)..(19)
<223>  C-term NH2

<400>  61

Ile Cys Val Trp Gln Asp Trp Gly Ala His Arg Cys Thr Gly Gly Gly 
1               5                   10                  15      


Gly Gly Lys 
            


<210>  62
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic peptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  N-term Ac

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  (CH2CH2O)nC(=O)Lys

<220>
<221>  misc_feature
<222>  (8)..(18)
<223>  Disulfide bond

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  (1Me)Trp

<220>
<221>  MOD_RES
<222>  (13)..(13)
<223>  C-term NH2

<400>  62

Lys Gly Gly Gly Gly Gly Ile Cys Val Trp Gln Asp Trp Gly Ala His 
1               5                   10                  15      


Arg Cys Thr 
            


<210>  63
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic peptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  N-term Ac

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  (CH2CH2O)nC(=O)Lys

<220>
<221>  misc_feature
<222>  (3)..(13)
<223>  Disulfide bond

<220>
<221>  MOD_RES
<222>  (5)..(5)
<223>  (1Me)Trp

<220>
<221>  MOD_RES
<222>  (14)..(14)
<223>  C-term NH2

<400>  63

Lys Ile Cys Val Trp Gln Asp Trp Gly Ala His Arg Cys Thr 
1               5                   10                  


<210>  64
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic peptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  N-term Ac

<220>
<221>  misc_feature
<222>  (2)..(12)
<223>  Disulfide bond

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  (1Me)Trp

<220>
<221>  MOD_RES
<222>  (14)..(14)
<223>  NH-CH2CH2OCH2CH2OCH2-C(=O)-Lys-(C(=O)-(CH2CH2O)n-R)

<220>
<221>  MOD_RES
<222>  (14)..(14)
<223>  C-term NH2

<400>  64

Ile Cys Val Trp Gln Asp Trp Gly Ala His Arg Cys Thr Lys 
1               5                   10                  


<210>  65
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic peptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  N-term Ac

<220>
<221>  misc_feature
<222>  (2)..(12)
<223>  Disulfide bond

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  (1Me)Trp

<220>
<221>  MOD_RES
<222>  (14)..(14)
<223>  NH-CH2CH2OCH2CH2OCH2-C(=O)-Lys-(C(=O)-(CH2)m- (CH2CH2O)n-R)

<220>
<221>  MOD_RES
<222>  (14)..(14)
<223>  C-term NH2

<400>  65

Ile Cys Val Trp Gln Asp Trp Gly Ala His Arg Cys Thr Lys 
1               5                   10                  


<210>  66
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic peptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  N-term Ac

<220>
<221>  misc_feature
<222>  (2)..(12)
<223>  Disulfide bond

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  (1Me)Trp

<220>
<221>  MOD_RES
<222>  (14)..(14)
<223>  NH-CH2CH2OCH2CH2OCH2-C(=O)-Lys-(C(=O)-(CH2)m-C(=O)- (CH2CH2O)n-R)

<220>
<221>  MOD_RES
<222>  (14)..(14)
<223>  C-term NH2

<400>  66

Ile Cys Val Trp Gln Asp Trp Gly Ala His Arg Cys Thr Lys 
1               5                   10                  


<210>  67
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic peptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  N-term Ac

<220>
<221>  misc_feature
<222>  (2)..(12)
<223>  Disulfide bond

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  (1Me)Trp

<220>
<221>  MOD_RES
<222>  (14)..(14)
<223>  NH-CH2CH2OCH2CH2OCH2-C(=O)-Lys-(C(=O)-(CH2)m-C(=O) 
       -(CH2)j(CH2CH2O)n-R)

<220>
<221>  MOD_RES
<222>  (14)..(14)
<223>  C-term NH2

<400>  67

Ile Cys Val Trp Gln Asp Trp Gly Ala His Arg Cys Thr Lys 
1               5                   10                  


<210>  68
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic peptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  N-term Ac

<220>
<221>  misc_feature
<222>  (2)..(12)
<223>  Disulfide bond

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  (1Me)Trp

<220>
<221>  MOD_RES
<222>  (14)..(14)
<223>  AEEAc-Lys-(C(=O)-(CH2)5-Mal)

<220>
<221>  MOD_RES
<222>  (14)..(14)
<223>  C-term NH2

<400>  68

Ile Cys Val Trp Gln Asp Trp Gly Ala His Arg Cys Thr Lys 
1               5                   10                  


<210>  69
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic peptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Any amino acid

<220>
<221>  MOD_RES
<222>  (2)..(4)
<223>  Any independently selected amino acid or amino acid analog

<220>
<221>  MOD_RES
<222>  (5)..(5)
<223>  Trp or analog of Trp

<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  Trp or analog of Trp

<220>
<221>  MOD_RES
<222>  (10)..(14)
<223>  Any independently selected amino acid or amino acid analog

<220>
<221>  MOD_RES
<222>  (15)..(15)
<223>  Any amino acid

<400>  69

Xaa Xaa Xaa Xaa Xaa Gln Asp Xaa Gly Xaa Xaa Xaa Xaa Xaa Xaa 
1               5                   10                  15  


<210>  70
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic peptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Any amino acid

<220>
<221>  MOD_RES
<222>  (2)..(3)
<223>  Ile, Val, Leu, B1-Ile, B1-Val, B1-Leu or a dipeptide comprising 
       Gly-Ile or B1-Gly-Ile, wherein B1 represents a first blocking 
       moiety

<220>
<221>  misc_feature
<222>  (2)..(3)
<223>  This region encompasses 1 to 2 residues (up to one position out 
       of two may be absent)

<220>
<221>  misc_feature
<222>  (4)..(14)
<223>  Disulfide bond

<220>
<221>  MOD_RES
<222>  (6)..(6)
<223>  Independently selected from Trp or analogs of Trp

<220>
<221>  MOD_RES
<222>  (9)..(9)
<223>  Independently selected from Trp or analogs of Trp

<220>
<221>  MOD_RES
<222>  (11)..(11)
<223>  His, Ala or an analog of Ala, Phe, Trp or an analog of Trp

<220>
<221>  MOD_RES
<222>  (15)..(17)
<223>  L-Thr, D-Thr, Ile, Val, Gly, a dipeptide selected from Thr-Ala or
       Thr-Asn, or a tripeptide comprising Thr-Ala-Asn, wherein a c-term
       -OH of any of the L-Thr, D-Thr, Ile, Val, Gly, Ala or Asn is 
       optionally replaced by a second blocking moiety

<220>
<221>  misc_feature
<222>  (15)..(17)
<223>  This region encompasses 1 to 3 residues (up to two positions out 
       of three may be absent)

<220>
<221>  MOD_RES
<222>  (18)..(18)
<223>  Any amino acid

<400>  70

Xaa Xaa Xaa Cys Val Xaa Gln Asp Xaa Gly Xaa His Arg Cys Xaa Xaa 
1               5                   10                  15      


Xaa Xaa 
        


<210>  71
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic peptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Any amino acid

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Ile or Gly

<220>
<221>  MOD_RES
<222>  (3)..(3)
<223>  Ile or Cys

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  Val or Cys

<220>
<221>  MOD_RES
<222>  (5)..(5)
<223>  Val, Tyr, Trp, 2-Nal, 1-Nal, 2-Igl, Dht, Bpa, Bta, 5f-Trp, 
       5-methyl-Trp, 1-methyl-Trp, 1-formyl-Trp or 1-methyoxy-Trp

<220>
<221>  MOD_RES
<222>  (6)..(6)
<223>  Gln, Trp, 6f-Trp or 5f-Trp

<220>
<221>  MOD_RES
<222>  (7)..(7)
<223>  Asp or Gln

<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  Trp, Asp or 5f-Trp

<220>
<221>  MOD_RES
<222>  (9)..(9)
<223>  Gly, Trp, 6f-Trp or 5f-Trp

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  His, Ala, 2-Abu or Gly

<220>
<221>  MOD_RES
<222>  (11)..(11)
<223>  His or Ala

<220>
<221>  MOD_RES
<222>  (12)..(12)
<223>  Arg or His

<220>
<221>  MOD_RES
<222>  (13)..(13)
<223>  Cys or Arg

<220>
<221>  MOD_RES
<222>  (14)..(14)
<223>  Thr, d-Thr or Cys

<220>
<221>  MOD_RES
<222>  (15)..(15)
<223>  Any amino acid

<400>  71

Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
1               5                   10                  15  


<210>  72
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic peptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Any amino acid

<220>
<221>  misc_feature
<222>  (3)..(13)
<223>  Disulfide bond

<220>
<221>  MOD_RES
<222>  (5)..(5)
<223>  Trp(Me)

<220>
<221>  MOD_RES
<222>  (9)..(9)
<223>  mGly

<220>
<221>  MOD_RES
<222>  (14)..(14)
<223>  mIle

<220>
<221>  MOD_RES
<222>  (15)..(15)
<223>  Any amino acid

<400>  72

Xaa Ile Cys Val Trp Gln Asp Trp Gly Ala His Arg Cys Ile Xaa 
1               5                   10                  15  


<210>  73
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic 6xHis tag

<400>  73

His His His His His His 
1               5       


<210>  74
<211>  5148
<212>  RNA
<213>  Homo sapiens


<220>
<221>  mRNA
<222>  (1)..(5148)
<223>  C3

<400>  74
agauaaaaag ccagcuccag caggcgcugc ucacuccucc ccauccucuc ccucuguccc       60

ucugucccuc ugacccugca cugucccagc accaugggac ccaccucagg ucccagccug      120

cugcuccugc uacuaaccca ccucccccug gcucugggga gucccaugua cucuaucauc      180

acccccaaca ucuugcggcu ggagagcgag gagaccaugg ugcuggaggc ccacgacgcg      240

caaggggaug uuccagucac uguuacuguc cacgacuucc caggcaaaaa acuagugcug      300

uccagugaga agacugugcu gaccccugcc accaaccaca ugggcaacgu caccuucacg      360

aucccagcca acagggaguu caagucagaa aaggggcgca acaaguucgu gaccgugcag      420

gccaccuucg ggacccaagu gguggagaag guggugcugg ucagccugca gagcggguac      480

cucuucaucc agacagacaa gaccaucuac accccuggcu ccacaguucu cuaucggauc      540

uucaccguca accacaagcu gcuacccgug ggccggacgg ucauggucaa cauugagaac      600

ccggaaggca ucccggucaa gcaggacucc uugucuucuc agaaccagcu uggcgucuug      660

cccuugucuu gggacauucc ggaacucguc aacaugggcc aguggaagau ccgagccuac      720

uaugaaaacu caccacagca ggucuucucc acugaguuug aggugaagga guacgugcug      780

cccaguuucg aggucauagu ggagccuaca gagaaauucu acuacaucua uaacgagaag      840

ggccuggagg ucaccaucac cgccagguuc cucuacggga agaaagugga gggaacugcc      900

uuugucaucu ucgggaucca ggauggcgaa cagaggauuu cccugccuga aucccucaag      960

cgcauuccga uugaggaugg cucgggggag guugugcuga gccggaaggu acugcuggac     1020

ggggugcaga acccccgagc agaagaccug guggggaagu cuuuguacgu gucugccacc     1080

gucaucuugc acucaggcag ugacauggug caggcagagc gcagcgggau ccccaucgug     1140

accucucccu accagaucca cuucaccaag acacccaagu acuucaaacc aggaaugccc     1200

uuugaccuca ugguguucgu gacgaacccu gauggcucuc cagccuaccg aguccccgug     1260

gcaguccagg gcgaggacac ugugcagucu cuaacccagg gagauggcgu ggccaaacuc     1320

agcaucaaca cacaccccag ccagaagccc uugagcauca cggugcgcac gaagaagcag     1380

gagcucucgg aggcagagca ggcuaccagg accaugcagg cucugcccua cagcaccgug     1440

ggcaacucca acaauuaccu gcaucucuca gugcuacgua cagagcucag acccggggag     1500

acccucaacg ucaacuuccu ccugcgaaug gaccgcgccc acgaggccaa gauccgcuac     1560

uacaccuacc ugaucaugaa caagggcagg cuguugaagg cgggacgcca ggugcgagag     1620

cccggccagg accugguggu gcugccccug uccaucacca ccgacuucau cccuuccuuc     1680

cgccuggugg cguacuacac gcugaucggu gccagcggcc agagggaggu gguggccgac     1740

uccguguggg uggacgucaa ggacuccugc gugggcucgc uggugguaaa aagcggccag     1800

ucagaagacc ggcagccugu accugggcag cagaugaccc ugaagauaga gggugaccac     1860

ggggcccggg ugguacuggu ggccguggac aagggcgugu ucgugcugaa uaagaagaac     1920

aaacugacgc agaguaagau cugggacgug guggagaagg cagacaucgg cugcaccccg     1980

ggcaguggga aggauuacgc cggugucuuc uccgacgcag ggcugaccuu cacgagcagc     2040

aguggccagc agaccgccca gagggcagaa cuucagugcc cgcagccagc cgcccgccga     2100

cgccguuccg ugcagcucac ggagaagcga auggacaaag ucggcaagua ccccaaggag     2160

cugcgcaagu gcugcgagga cggcaugcgg gagaacccca ugagguucuc gugccagcgc     2220

cggacccguu ucaucucccu gggcgaggcg ugcaagaagg ucuuccugga cugcugcaac     2280

uacaucacag agcugcggcg gcagcacgcg cgggccagcc accugggccu ggccaggagu     2340

aaccuggaug aggacaucau ugcagaagag aacaucguuu cccgaaguga guucccagag     2400

agcuggcugu ggaacguuga ggacuugaaa gagccaccga aaaauggaau cucuacgaag     2460

cucaugaaua uauuuuugaa agacuccauc accacguggg agauucuggc ugugagcaug     2520

ucggacaaga aagggaucug uguggcagac cccuucgagg ucacaguaau gcaggacuuc     2580

uucaucgacc ugcggcuacc cuacucuguu guucgaaacg agcaggugga aauccgagcc     2640

guucucuaca auuaccggca gaaccaagag cucaagguga ggguggaacu acuccacaau     2700

ccagccuucu gcagccuggc caccaccaag aggcgucacc agcagaccgu aaccaucccc     2760

cccaaguccu cguuguccgu uccauauguc aucgugccgc uaaagaccgg ccugcaggaa     2820

guggaaguca aggcugcugu cuaccaucau uucaucagug acggugucag gaagucccug     2880

aaggucgugc cggaaggaau cagaaugaac aaaacugugg cuguucgcac ccuggaucca     2940

gaacgccugg gccgugaagg agugcagaaa gaggacaucc caccugcaga ccucagugac     3000

caagucccgg acaccgaguc ugagaccaga auucuccugc aagggacccc aguggcccag     3060

augacagagg augccgucga cgcggaacgg cugaagcacc ucauugugac ccccucgggc     3120

ugcggggaac agaacaugau cggcaugacg cccacgguca ucgcugugca uuaccuggau     3180

gaaacggagc agugggagaa guucggccua gagaagcggc agggggccuu ggagcucauc     3240

aagaaggggu acacccagca gcuggccuuc agacaaccca gcucugccuu ugcggccuuc     3300

gugaaacggg cacccagcac cuggcugacc gccuacgugg ucaaggucuu cucucuggcu     3360

gucaaccuca ucgccaucga cucccaaguc cucugcgggg cuguuaaaug gcugauccug     3420

gagaagcaga agcccgacgg ggucuuccag gaggaugcgc ccgugauaca ccaagaaaug     3480

auugguggau uacggaacaa caacgagaaa gacauggccc ucacggccuu uguucucauc     3540

ucgcugcagg aggcuaaaga uauuugcgag gagcagguca acagccugcc aggcagcauc     3600

acuaaagcag gagacuuccu ugaagccaac uacaugaacc uacagagauc cuacacugug     3660

gccauugcug gcuaugcucu ggcccagaug ggcaggcuga aggggccucu ucuuaacaaa     3720

uuucugacca cagccaaaga uaagaaccgc ugggaggacc cugguaagca gcucuacaac     3780

guggaggcca cauccuaugc ccucuuggcc cuacugcagc uaaaagacuu ugacuuugug     3840

ccucccgucg ugcguuggcu caaugaacag agauacuacg gugguggcua uggcucuacc     3900

caggccaccu ucaugguguu ccaagccuug gcucaauacc aaaaggacgc cccugaccac     3960

caggaacuga accuugaugu gucccuccaa cugcccagcc gcagcuccaa gaucacccac     4020

cguauccacu gggaaucugc cagccuccug cgaucagaag agaccaagga aaaugagggu     4080

uucacaguca cagcugaagg aaaaggccaa ggcaccuugu cgguggugac aauguaccau     4140

gcuaaggcca aagaucaacu caccuguaau aaauucgacc ucaaggucac cauaaaacca     4200

gcaccggaaa cagaaaagag gccucaggau gccaagaaca cuaugauccu ugagaucugu     4260

accagguacc ggggagacca ggaugccacu augucuauau uggacauauc caugaugacu     4320

ggcuuugcuc cagacacaga ugaccugaag cagcuggcca augguguuga cagauacauc     4380

uccaaguaug agcuggacaa agccuucucc gauaggaaca cccucaucau cuaccuggac     4440

aaggucucac acucugagga ugacugucua gcuuucaaag uucaccaaua cuuuaaugua     4500

gagcuuaucc agccuggagc agucaagguc uacgccuauu acaaccugga ggaaagcugu     4560

acccgguucu accauccgga aaaggaggau ggaaagcuga acaagcucug ccgugaugaa     4620

cugugccgcu gugcugagga gaauugcuuc auacaaaagu cggaugacaa ggucacccug     4680

gaagaacggc uggacaaggc cugugagcca ggaguggacu auguguacaa gacccgacug     4740

gucaagguuc agcuguccaa ugacuuugac gaguacauca uggccauuga gcagaccauc     4800

aagucaggcu cggaugaggu gcagguugga cagcagcgca cguucaucag ccccaucaag     4860

ugcagagaag cccugaagcu ggaggagaag aaacacuacc ucaugugggg ucucuccucc     4920

gauuucuggg gagagaagcc caaccucagc uacaucaucg ggaaggacac uuggguggag     4980

cacuggcccg aggaggacga augccaagac gaagagaacc agaaacaaug ccaggaccuc     5040

ggcgccuuca ccgagagcau gguugucuuu gggugcccca acugaccaca cccccauucc     5100

cccacuccag auaaagcuuc aguuauaucu caaaaaaaaa aaaaaaaa                  5148


<210>  75
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  75
aaacugacgc agaguaaga                                                    19


<210>  76
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  76
aaagaucaac ucaccugua                                                    19


<210>  77
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  77
aacaagcucu gccgugaug                                                    19


<210>  78
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  78
aagaaacacu accucaugu                                                    19


<210>  79
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  79
aagaaaugau ugguggauu                                                    19


<210>  80
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  80
aagaucaacu caccuguaa                                                    19


<210>  81
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  81
acaaagccuu cuccgauag                                                    19


<210>  82
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  82
acaccuaccu gaucaugaa                                                    19


<210>  83
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  83
acagggaguu caagucaga                                                    19


<210>  84
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  84
acaugaaccu acagagauc                                                    19


<210>  85
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  85
acgaagagaa ccagaaaca                                                    19


<210>  86
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  86
acgaaugcca agacgaaga                                                    19


<210>  87
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  87
acggaacaac aacgagaaa                                                    19


<210>  88
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  88
acggagaagc gaauggaca                                                    19


<210>  89
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  89
acguugagga cuugaaaga                                                    19


<210>  90
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  90
agaaaugauu gguggauua                                                    19


<210>  91
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  91
agaacacuau gauccuuga                                                    19


<210>  92
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  92
agacacagau gaccugaag                                                    19


<210>  93
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  93
agacagacaa gaccaucua                                                    19


<210>  94
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  94
agacgaagag aaccagaaa                                                    19


<210>  95
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  95
agaugacccu gaagauaga                                                    19


<210>  96
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  96
aggauggaaa gcugaacaa                                                    19


<210>  97
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  97
agggaguuca agucagaaa                                                    19


<210>  98
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  98
agguucagcu guccaauga                                                    19


<210>  99
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  99
agucacagcu gaaggaaaa                                                    19


<210>  100
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  100
aguggagccu acagagaaa                                                    19


<210>  101
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  101
aguuugaggu gaaggagua                                                    19


<210>  102
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  102
auuacaaccu ggaggaaag                                                    19


<210>  103
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  103
caacaacgag aaagacaug                                                    19


<210>  104
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  104
caacagggag uucaaguca                                                    19


<210>  105
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  105
caacccagcu cugccuuug                                                    19


<210>  106
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  106
caacucaccu guaauaaau                                                    19


<210>  107
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  107
caagaacacu augauccuu                                                    19


<210>  108
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  108
caagaucacc caccguauc                                                    19


<210>  109
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  109
caaggucacc cuggaagaa                                                    19


<210>  110
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  110
caccaauacu uuaauguag                                                    19


<210>  111
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  111
cagaagaccu gguggggaa                                                    19


<210>  112
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  112
cagaagagaa caucguuuc                                                    19


<210>  113
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  113
cagaagagac caaggaaaa                                                    19


<210>  114
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  114
cagaagcccu ugagcauca                                                    19


<210>  115
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  115
cagauccacu ucaccaaga                                                    19


<210>  116
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  116
cagaugaccc ugaagauag                                                    19


<210>  117
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  117
cagcagcgca cguucauca                                                    19


<210>  118
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  118
cagcaucacu aaagcagga                                                    19


<210>  119
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  119
cagucaaggu cuacgccua                                                    19


<210>  120
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  120
cagucacagc ugaaggaaa                                                    19


<210>  121
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  121
caucauugca gaagagaac                                                    19


<210>  122
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  122
ccaacuacau gaaccuaca                                                    19


<210>  123
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  123
ccaagacacc caaguacuu                                                    19


<210>  124
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  124
ccaaggaaaa ugaggguuu                                                    19


<210>  125
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  125
ccaaggagcu gcgcaagug                                                    19


<210>  126
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  126
ccaaguauga gcuggacaa                                                    19


<210>  127
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  127
ccaaugacuu ugacgagua                                                    19


<210>  128
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  128
ccaauggugu ugacagaua                                                    19


<210>  129
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  129
ccaccaacca caugggcaa                                                    19


<210>  130
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  130
ccacugaguu ugaggugaa                                                    19


<210>  131
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  131
cccugaagcu ggaggagaa                                                    19


<210>  132
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  132
ccggaaggaa ucagaauga                                                    19


<210>  133
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  133
ccgugaagga gugcagaaa                                                    19


<210>  134
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  134
ccgugauaca ccaagaaau                                                    19


<210>  135
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  135
ccgugugggu ggacgucaa                                                    19


<210>  136
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  136
ccuacagcac cgugggcaa                                                    19


<210>  137
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  137
ccuaccugau caugaacaa                                                    19


<210>  138
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  138
ccucaagcgc auuccgauu                                                    19


<210>  139
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  139
cgaaacgagc agguggaaa                                                    19


<210>  140
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  140
cgaagcucau gaauauauu                                                    19


<210>  141
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  141
cgaagugagu ucccagaga                                                    19


<210>  142
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  142
cggaaaagga ggauggaaa                                                    19


<210>  143
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  143
cggaaggcau cccggucaa                                                    19


<210>  144
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  144
cggagaagcg aauggacaa                                                    19


<210>  145
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  145
cggcuacccu acucuguug                                                    19


<210>  146
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  146
cgggcagugg gaaggauua                                                    19


<210>  147
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  147
cggucaucgc ugugcauua                                                    19


<210>  148
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  148
cuacaucuau aacgagaag                                                    19


<210>  149
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  149
cuacaugaac cuacagaga                                                    19


<210>  150
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  150
cuacgaagcu caugaauau                                                    19


<210>  151
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  151
cugaauaaga agaacaaac                                                    19


<210>  152
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  152
cugcaggagg cuaaagaua                                                    19


<210>  153
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  153
cuggagcagu caaggucua                                                    19


<210>  154
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  154
cuugaaagag ccaccgaaa                                                    19


<210>  155
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  155
gaaacgagca gguggaaau                                                    19


<210>  156
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  156
gaaacggagc agugggaga                                                    19


<210>  157
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  157
gaacaacaac gagaaagac                                                    19


<210>  158
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  158
gaacaagcuc ugccgugau                                                    19


<210>  159
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  159
gaacagaaca ugaucggca                                                    19


<210>  160
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  160
gaacaucguu ucccgaagu                                                    19


<210>  161
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  161
gaaccagcuu ggcgucuug                                                    19


<210>  162
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  162
gaacguugag gacuugaaa                                                    19


<210>  163
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  163
gaacugaacc uugaugugu                                                    19


<210>  164
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  164
gaacugccuu ugucaucuu                                                    19


<210>  165
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  165
gaagaaacac uaccucaug                                                    19


<210>  166
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  166
gaagagaacc agaaacaau                                                    19


<210>  167
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  167
gaagauccga gccuacuau                                                    19


<210>  168
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  168
gaaggaauca gaaugaaca                                                    19


<210>  169
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  169
gaaguucggc cuagagaag                                                    19


<210>  170
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  170
gaauggacaa agucggcaa                                                    19


<210>  171
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  171
gacaaagccu ucuccgaua                                                    19


<210>  172
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  172
gaccacagcc aaagauaag                                                    19


<210>  173
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  173
gaccagaauu cuccugcaa                                                    19


<210>  174
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  174
gagaaguucg gccuagaga                                                    19


<210>  175
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  175
gagaauugcu ucauacaaa                                                    19


<210>  176
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  176
gagccguucu cuacaauua                                                    19


<210>  177
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  177
gaggagaauu gcuucauac                                                    19


<210>  178
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  178
gaggaugacu gucuagcuu                                                    19


<210>  179
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  179
gagugcagaa agaggacau                                                    19


<210>  180
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  180
gaguggacua uguguacaa                                                    19


<210>  181
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  181
gauaggaaca cccucauca                                                    19


<210>  182
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  182
gaucaacuca ccuguaaua                                                    19


<210>  183
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  183
gaucagaaga gaccaagga                                                    19


<210>  184
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  184
gauccgagcc uacuaugaa                                                    19


<210>  185
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  185
gcaacaaguu cgugaccgu                                                    19


<210>  186
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  186
gcagaagaga acaucguuu                                                    19


<210>  187
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  187
gcagaugacc cugaagaua                                                    19


<210>  188
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  188
gcagcuggcc uucagacaa                                                    19


<210>  189
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  189
gcaggaggcu aaagauauu                                                    19


<210>  190
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  190
gccaagacga agagaacca                                                    19


<210>  191
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  191
gccagaagcc cuugagcau                                                    19


<210>  192
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  192
gcgcauuccg auugaggau                                                    19


<210>  193
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  193
gcgccuucac cgagagcau                                                    19


<210>  194
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  194
gcguguucgu gcugaauaa                                                    19


<210>  195
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  195
gcucugccgu gaugaacug                                                    19


<210>  196
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  196
ggaacaacaa cgagaaaga                                                    19


<210>  197
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  197
ggaacacccu caucaucua                                                    19


<210>  198
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  198
ggaacugccu uugucaucu                                                    19


<210>  199
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  199
ggaagaaagu ggagggaac                                                    19


<210>  200
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  200
ggaagauccg agccuacua                                                    19


<210>  201
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  201
ggaaggaauc agaaugaac                                                    19


<210>  202
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  202
ggaaucagaa ugaacaaaa                                                    19


<210>  203
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  203
ggacaaaguc ggcaaguac                                                    19


<210>  204
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  204
ggacaaggcc ugugagcca                                                    19


<210>  205
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  205
ggacaagguc ucacacucu                                                    19


<210>  206
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  206
ggacagcagc gcacguuca                                                    19


<210>  207
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  207
ggacauaucc augaugacu                                                    19


<210>  208
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  208
ggacaucauu gcagaagag                                                    19


<210>  209
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  209
ggacccaagu gguggagaa                                                    19


<210>  210
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  210
ggacgaaugc caagacgaa                                                    19


<210>  211
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  211
ggacggucau ggucaacau                                                    19


<210>  212
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  212
ggagaagcga auggacaaa                                                    19


<210>  213
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  213
ggagaauugc uucauacaa                                                    19


<210>  214
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  214
ggagagaagc ccaaccuca                                                    19


<210>  215
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  215
ggagggaacu gccuuuguc                                                    19


<210>  216
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  216
ggaguaaccu ggaugagga                                                    19


<210>  217
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  217
ggaugacugu cuagcuuuc                                                    19


<210>  218
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  218
ggaugccacu augucuaua                                                    19


<210>  219
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  219
ggauuacgcc ggugucuuc                                                    19


<210>  220
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  220
ggcagaacca agagcucaa                                                    19


<210>  221
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  221
ggcagcagau gacccugaa                                                    19


<210>  222
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  222
ggccaauggu guugacaga                                                    19


<210>  223
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  223
ggccucuucu uaacaaauu                                                    19


<210>  224
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  224
ggcucaauga acagagaua                                                    19


<210>  225
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  225
gggaagaaag uggagggaa                                                    19


<210>  226
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  226
gggagacccu caacgucaa                                                    19


<210>  227
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  227
ggucaucgcu gugcauuac                                                    19


<210>  228
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  228
ggucuucucc acugaguuu                                                    19


<210>  229
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  229
guaagcagcu cuacaacgu                                                    19


<210>  230
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  230
guaauaaauu cgaccucaa                                                    19


<210>  231
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  231
gugaaggagu gcagaaaga                                                    19


<210>  232
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  232
gugacaaugu accaugcua                                                    19


<210>  233
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  233
gugacauggu gcaggcaga                                                    19


<210>  234
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  234
gugcauuacc uggaugaaa                                                    19


<210>  235
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  235
gugcugaaua agaagaaca                                                    19


<210>  236
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  236
gugggcaacu ccaacaauu                                                    19


<210>  237
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  237
guucaccaau acuuuaaug                                                    19


<210>  238
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  238
ucaacucacc uguaauaaa                                                    19


<210>  239
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  239
ucaaugaaca gagauacua                                                    19


<210>  240
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  240
ucacaguaau gcaggacuu                                                    19


<210>  241
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  241
ucaccaagac acccaagua                                                    19


<210>  242
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  242
ucagaagaga ccaaggaaa                                                    19


<210>  243
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  243
ucuacgaagc ucaugaaua                                                    19


<210>  244
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  244
ucugggacgu gguggagaa                                                    19


<210>  245
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  245
ugaagcagcu ggccaaugg                                                    19


<210>  246
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  246
ugaagcugga ggagaagaa                                                    19


<210>  247
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  247
ugacaaugua ccaugcuaa                                                    19


<210>  248
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  248
ugaccacagc caaagauaa                                                    19


<210>  249
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  249
ugaggagaau ugcuucaua                                                    19


<210>  250
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  250
ugcaggaagu ggaagucaa                                                    19


<210>  251
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  251
ugcuaaggcc aaagaucaa                                                    19


<210>  252
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  252
uggaagaacg gcuggacaa                                                    19


<210>  253
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  253
uggcuuugcu ccagacaca                                                    19


<210>  254
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  254
uguggaacgu ugaggacuu                                                    19


<210>  255
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  255
uuucaaaguu caccaauac                                                    19


<210>  256
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  256
aauccgagcc guucucuaca a                                                 21


<210>  257
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  257
aacaagcucu gccgugauga a                                                 21


<210>  258
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  258
aauggacaaa gucggcaagu a                                                 21


<210>  259
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  259
aacuacauga accuacagag a                                                 21


<210>  260
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  260
aaaaagcggc cagucagaag a                                                 21


<210>  261
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  261
aaugauuggu ggauuacgga a                                                 21


<210>  262
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  262
aaguccucgu uguccguucc a                                                 21


<210>  263
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  263
aaaugauugg uggauuacgg a                                                 21


<210>  264
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  264
aauuaccggc agaaccaaga g                                                 21


<210>  265
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  265
aaauggaauc ucuacgaagc u                                                 21


<210>  266
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  266
aaugaacaga gauacuacgg u                                                 21


<210>  267
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  267
aagccuuggc ucaauaccaa a                                                 21


<210>  268
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  268
aagcgcauuc cgauugagga u                                                 21


<210>  269
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  269
aauggaaucu cuacgaagcu c                                                 21


<210>  270
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  270
aaccucaucg ccaucgacuc c                                                 21


<210>  271
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic peptide


<220>
<221>  MOD_RES
<222>  (3)..(3)
<223>  Trp or an analog of Trp

<400>  271

Gln Asp Xaa Gly 
1               


<210>  272
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic peptide


<220>
<221>  misc_feature
<222>  (2)..(12)
<223>  Disulfide bond

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  (1Me)Trp

<400>  272

Ile Cys Val Trp Gln Asp Trp Gly Ala His Arg Cys Thr 
1               5                   10              


