                         SEQUENCE LISTING

<110>  PIONEER HI-BRED INTERNATIONAL, INC.
       Abad, Andre Roger
       Crow, Andrew Carl
       Poland, Brad
       Wang, Jimei
 
<120>  BROAD SPECTRUM INSECTICIDAL POLYPEPTIDE AGAINST LEPIDOPTERAN 
       PESTS AND METHODS OF USE THEREOF

<130>  7157-WO-PCT


<150>  62/410045
<151>  2016-10-19

<160>  7     

<170>  PatentIn version 3.5

<210>  1
<211>  3528
<212>  DNA
<213>  Bacillus thuringiensis

<400>  1
atggataata ataatcaaaa tcaatgcata ccttacaatt gtttaagtaa tcctgaatta       60

gagatattag agattgaaag atcaaataat accgtagtag aagacatcac cttggggctg      120

agtcgtctgc tcgtttccgc aattccacta ggggatttta tacttggctt gtttgatgta      180

atatgggggg ctttaggtcg ttcagagtgg gatatatttt tagagcaaat tgagctattg      240

atcggccaaa gaatagagga atttgctagg aatcaggcaa tttctagatt agaagggcta      300

agcaatcttt atcgaattta cacaaatgct tttaaagact gggaagcaga tcctactaat      360

ctagaattaa aagaagagat gcgtactcaa tttaatgaca tgaacagtgc ttttacaaca      420

gctattcctc ttttttcagt tcgaggttat gaacttcctc ttttatcagt atatgttcaa      480

gctgcaaatt tacatttatc agttttaaga gatgtttcag tgtttggaca acgttgggga      540

tttgacgtag caacagtcaa tcgtcgttat gatgatttaa ctacgaatat aggcgactac      600

acagattatg ctttaagctg gtataatacg ggattaaacc gtttaccacg taatgatggg      660

ctgcgaggat gggcaagatt taataggttt agaagagagt taacaatatc agtattagat      720

attatttctt ttttccaaaa ttacgattct agattatatc caattccaac aatctcccaa      780

ttaacgcggg aagtatatac agatccggta attaatataa ctgattatag agttacccca      840

agtttcgaga gtattgaaaa ctcagccatt agaagccccc atcttatgga tttcttaact      900

aatataatta ttgacactga tttaataaga ggtgtttact attgggcagg acatcgtata      960

aattctcgct ttaccgggac cgcttttcca catataataa catctcctca atatggaata     1020

actgcaaacg cagaaccaag acgtacaata gcgcctggtc cttttcaagg tgtgccttcc     1080

ctactttata gaacactatc agaccctttc ttccgaagat cagacaatat tagtccaacc     1140

ttagggataa atgtagtaca gggggtaggg ttcttacaac caaataattt tgaatctcta     1200

tatagaagga gagggacagt agattctctc gatgagttgc caattgatgg tgaaaatcca     1260

ttagttggat atagtcatcg attaagtcac gttacattaa ccaggtcatt atttaatact     1320

aatataacta gcctgccaac atttgtttgg acacatcaca gtgctactga tacaaataca     1380

attgctccag atgtcattac ccaaataccg ttagtaaagg ctttcaatct tcattcaggt     1440

gccacggttg ctagagggcc aggatttaca ggtggggata tccttcgaag aacgaatgtt     1500

ggtaactttg gagatatgcg tgtaaatatt actgcaccac tatcacaaag atatcgagta     1560

aggattcgtt atgcttctac tacaaattta cgattccata catcaattaa cggaagagct     1620

attaatcagg cggattttcc agctactatg aatagtgggg gtaatttaca gtccggtagc     1680

ttcaggattg caggttttac tactccattt accttttcag atgcactaag cacattcaca     1740

ataggtgctt ttggcttctc ttcaggtaac gaagtttata tagatcgaat tgaatttgtt     1800

ccggcagaag taacctttga ggcagaatat gatctagaaa gagcacaaaa ggcggtgaat     1860

gcgctgttta cttcttctaa tcaaatcggg ttaaaaacag atgtaacgga ttatcatatt     1920

gatcaagtat caaatctagt tgaatgctta tcggatgaat tttgtctgga tgaaaagcga     1980

gaattgtctg agaaagtcaa acatgcgaag cgactcagcg atgagcgcaa tttactccag     2040

gatcgaaatt tcagatccat taatgggcaa ctagaccgtg gctggagagg aagtacggat     2100

attaccatcc aaggtggaga tgacgtattc aaagagaatt acgtcacact gccgggtacc     2160

tttgatgagt gctatccaac gtatctatat caaaaaatag atgaatcgaa attaaaatcc     2220

tatacacgtt acgagttaag agggtatatc gaggatagtc aagatttaga aatctatttg     2280

attcgctaca atgcaaaaca cgaaatagta aatgtaccag gtacagggag tttatggcct     2340

ctttctatag aaaattcaat tgggccttgt ggagaaccga atcgctgcgc gccacacctt     2400

gaatggaatc ctaatctaga ttgttcctgc agggacgggg aaaaatgtgc ccatcattcc     2460

catcatttct ccttggacat tgatgttgga tgtacagact taaatgagga cttaggtgta     2520

tgggtgatct tcaagattaa gacgcaagat ggccatgcaa gactaggaaa tctagaattt     2580

ctcgaagaga aaccactatt aggggaagca ctagctcgtg tgaaaagagc ggagaagaaa     2640

tggagagaca aacgcgaaaa attggaatgg gaaacaaata ttgtttataa agaggcaaaa     2700

gaatctgtag atgctttatt tgtgaactct caatatgata gattacaagc ggatacgaat     2760

atcgcgatga ttcatgcggc agataaacgc gttcatagaa ttagagaagc ataccttcca     2820

gaattatctg taattccggg tgtaaatgcg ggcattttcg aagaattaga gggacgcatt     2880

ttcacagcct actctctata tgatgcgaga aatgtcatta aaaatggcga tttcaataat     2940

ggtttattgt gctggaactt gaaagggcat gtagatgtag aagaacaaaa caaccatcgt     3000

tcagtccttg ttgtcccgga atgggaagca gaggtgtccc aagaagttcg tgtctgtcca     3060

ggtcgtggct atatccttcg tgttacagcg tacaaagagg gatatggaga gggctgcgta     3120

accattcatg agatcgaaga caatacagac gaactgaaat ttagcaactg tgttgaagag     3180

gaagtatatc caaacaacac ggtaacgtgt aatgattata ctgcgactca agaagaatac     3240

gggggtgcgt acacttcccg taatcatgga tatggcaaat cttatgaaag taattcttcc     3300

gtacaagctg attatgcgtc agtttatgaa gaaaaagcgg acacagatgg acgaagagat     3360

aatcattgcg aatctaacag agggtatggg gattacacgc cactaccagc tggttatgta     3420

acaaaagaat tagaatactt cccagaaacc gataaggtat gggttgagat tggagaaacg     3480

gaaggaacat tcattgtgga tagtgtggaa ttactcctta tggaggaa                  3528


<210>  2
<211>  1176
<212>  PRT
<213>  Bacillus thuringiensis

<400>  2

Met Asp Asn Asn Asn Gln Asn Gln Cys Ile Pro Tyr Asn Cys Leu Ser 
1               5                   10                  15      


Asn Pro Glu Leu Glu Ile Leu Glu Ile Glu Arg Ser Asn Asn Thr Val 
            20                  25                  30          


Val Glu Asp Ile Thr Leu Gly Leu Ser Arg Leu Leu Val Ser Ala Ile 
        35                  40                  45              


Pro Leu Gly Asp Phe Ile Leu Gly Leu Phe Asp Val Ile Trp Gly Ala 
    50                  55                  60                  


Leu Gly Arg Ser Glu Trp Asp Ile Phe Leu Glu Gln Ile Glu Leu Leu 
65                  70                  75                  80  


Ile Gly Gln Arg Ile Glu Glu Phe Ala Arg Asn Gln Ala Ile Ser Arg 
                85                  90                  95      


Leu Glu Gly Leu Ser Asn Leu Tyr Arg Ile Tyr Thr Asn Ala Phe Lys 
            100                 105                 110         


Asp Trp Glu Ala Asp Pro Thr Asn Leu Glu Leu Lys Glu Glu Met Arg 
        115                 120                 125             


Thr Gln Phe Asn Asp Met Asn Ser Ala Phe Thr Thr Ala Ile Pro Leu 
    130                 135                 140                 


Phe Ser Val Arg Gly Tyr Glu Leu Pro Leu Leu Ser Val Tyr Val Gln 
145                 150                 155                 160 


Ala Ala Asn Leu His Leu Ser Val Leu Arg Asp Val Ser Val Phe Gly 
                165                 170                 175     


Gln Arg Trp Gly Phe Asp Val Ala Thr Val Asn Arg Arg Tyr Asp Asp 
            180                 185                 190         


Leu Thr Thr Asn Ile Gly Asp Tyr Thr Asp Tyr Ala Leu Ser Trp Tyr 
        195                 200                 205             


Asn Thr Gly Leu Asn Arg Leu Pro Arg Asn Asp Gly Leu Arg Gly Trp 
    210                 215                 220                 


Ala Arg Phe Asn Arg Phe Arg Arg Glu Leu Thr Ile Ser Val Leu Asp 
225                 230                 235                 240 


Ile Ile Ser Phe Phe Gln Asn Tyr Asp Ser Arg Leu Tyr Pro Ile Pro 
                245                 250                 255     


Thr Ile Ser Gln Leu Thr Arg Glu Val Tyr Thr Asp Pro Val Ile Asn 
            260                 265                 270         


Ile Thr Asp Tyr Arg Val Thr Pro Ser Phe Glu Ser Ile Glu Asn Ser 
        275                 280                 285             


Ala Ile Arg Ser Pro His Leu Met Asp Phe Leu Thr Asn Ile Ile Ile 
    290                 295                 300                 


Asp Thr Asp Leu Ile Arg Gly Val Tyr Tyr Trp Ala Gly His Arg Ile 
305                 310                 315                 320 


Asn Ser Arg Phe Thr Gly Thr Ala Phe Pro His Ile Ile Thr Ser Pro 
                325                 330                 335     


Gln Tyr Gly Ile Thr Ala Asn Ala Glu Pro Arg Arg Thr Ile Ala Pro 
            340                 345                 350         


Gly Pro Phe Gln Gly Val Pro Ser Leu Leu Tyr Arg Thr Leu Ser Asp 
        355                 360                 365             


Pro Phe Phe Arg Arg Ser Asp Asn Ile Ser Pro Thr Leu Gly Ile Asn 
    370                 375                 380                 


Val Val Gln Gly Val Gly Phe Leu Gln Pro Asn Asn Phe Glu Ser Leu 
385                 390                 395                 400 


Tyr Arg Arg Arg Gly Thr Val Asp Ser Leu Asp Glu Leu Pro Ile Asp 
                405                 410                 415     


Gly Glu Asn Pro Leu Val Gly Tyr Ser His Arg Leu Ser His Val Thr 
            420                 425                 430         


Leu Thr Arg Ser Leu Phe Asn Thr Asn Ile Thr Ser Leu Pro Thr Phe 
        435                 440                 445             


Val Trp Thr His His Ser Ala Thr Asp Thr Asn Thr Ile Ala Pro Asp 
    450                 455                 460                 


Val Ile Thr Gln Ile Pro Leu Val Lys Ala Phe Asn Leu His Ser Gly 
465                 470                 475                 480 


Ala Thr Val Ala Arg Gly Pro Gly Phe Thr Gly Gly Asp Ile Leu Arg 
                485                 490                 495     


Arg Thr Asn Val Gly Asn Phe Gly Asp Met Arg Val Asn Ile Thr Ala 
            500                 505                 510         


Pro Leu Ser Gln Arg Tyr Arg Val Arg Ile Arg Tyr Ala Ser Thr Thr 
        515                 520                 525             


Asn Leu Arg Phe His Thr Ser Ile Asn Gly Arg Ala Ile Asn Gln Ala 
    530                 535                 540                 


Asp Phe Pro Ala Thr Met Asn Ser Gly Gly Asn Leu Gln Ser Gly Ser 
545                 550                 555                 560 


Phe Arg Ile Ala Gly Phe Thr Thr Pro Phe Thr Phe Ser Asp Ala Leu 
                565                 570                 575     


Ser Thr Phe Thr Ile Gly Ala Phe Gly Phe Ser Ser Gly Asn Glu Val 
            580                 585                 590         


Tyr Ile Asp Arg Ile Glu Phe Val Pro Ala Glu Val Thr Phe Glu Ala 
        595                 600                 605             


Glu Tyr Asp Leu Glu Arg Ala Gln Lys Ala Val Asn Ala Leu Phe Thr 
    610                 615                 620                 


Ser Ser Asn Gln Ile Gly Leu Lys Thr Asp Val Thr Asp Tyr His Ile 
625                 630                 635                 640 


Asp Gln Val Ser Asn Leu Val Glu Cys Leu Ser Asp Glu Phe Cys Leu 
                645                 650                 655     


Asp Glu Lys Arg Glu Leu Ser Glu Lys Val Lys His Ala Lys Arg Leu 
            660                 665                 670         


Ser Asp Glu Arg Asn Leu Leu Gln Asp Arg Asn Phe Arg Ser Ile Asn 
        675                 680                 685             


Gly Gln Leu Asp Arg Gly Trp Arg Gly Ser Thr Asp Ile Thr Ile Gln 
    690                 695                 700                 


Gly Gly Asp Asp Val Phe Lys Glu Asn Tyr Val Thr Leu Pro Gly Thr 
705                 710                 715                 720 


Phe Asp Glu Cys Tyr Pro Thr Tyr Leu Tyr Gln Lys Ile Asp Glu Ser 
                725                 730                 735     


Lys Leu Lys Ser Tyr Thr Arg Tyr Glu Leu Arg Gly Tyr Ile Glu Asp 
            740                 745                 750         


Ser Gln Asp Leu Glu Ile Tyr Leu Ile Arg Tyr Asn Ala Lys His Glu 
        755                 760                 765             


Ile Val Asn Val Pro Gly Thr Gly Ser Leu Trp Pro Leu Ser Ile Glu 
    770                 775                 780                 


Asn Ser Ile Gly Pro Cys Gly Glu Pro Asn Arg Cys Ala Pro His Leu 
785                 790                 795                 800 


Glu Trp Asn Pro Asn Leu Asp Cys Ser Cys Arg Asp Gly Glu Lys Cys 
                805                 810                 815     


Ala His His Ser His His Phe Ser Leu Asp Ile Asp Val Gly Cys Thr 
            820                 825                 830         


Asp Leu Asn Glu Asp Leu Gly Val Trp Val Ile Phe Lys Ile Lys Thr 
        835                 840                 845             


Gln Asp Gly His Ala Arg Leu Gly Asn Leu Glu Phe Leu Glu Glu Lys 
    850                 855                 860                 


Pro Leu Leu Gly Glu Ala Leu Ala Arg Val Lys Arg Ala Glu Lys Lys 
865                 870                 875                 880 


Trp Arg Asp Lys Arg Glu Lys Leu Glu Trp Glu Thr Asn Ile Val Tyr 
                885                 890                 895     


Lys Glu Ala Lys Glu Ser Val Asp Ala Leu Phe Val Asn Ser Gln Tyr 
            900                 905                 910         


Asp Arg Leu Gln Ala Asp Thr Asn Ile Ala Met Ile His Ala Ala Asp 
        915                 920                 925             


Lys Arg Val His Arg Ile Arg Glu Ala Tyr Leu Pro Glu Leu Ser Val 
    930                 935                 940                 


Ile Pro Gly Val Asn Ala Gly Ile Phe Glu Glu Leu Glu Gly Arg Ile 
945                 950                 955                 960 


Phe Thr Ala Tyr Ser Leu Tyr Asp Ala Arg Asn Val Ile Lys Asn Gly 
                965                 970                 975     


Asp Phe Asn Asn Gly Leu Leu Cys Trp Asn Leu Lys Gly His Val Asp 
            980                 985                 990         


Val Glu Glu Gln Asn Asn His Arg  Ser Val Leu Val Val  Pro Glu Trp 
        995                 1000                 1005             


Glu Ala  Glu Val Ser Gln Glu  Val Arg Val Cys Pro  Gly Arg Gly 
    1010                 1015                 1020             


Tyr Ile  Leu Arg Val Thr Ala  Tyr Lys Glu Gly Tyr  Gly Glu Gly 
    1025                 1030                 1035             


Cys Val  Thr Ile His Glu Ile  Glu Asp Asn Thr Asp  Glu Leu Lys 
    1040                 1045                 1050             


Phe Ser  Asn Cys Val Glu Glu  Glu Val Tyr Pro Asn  Asn Thr Val 
    1055                 1060                 1065             


Thr Cys  Asn Asp Tyr Thr Ala  Thr Gln Glu Glu Tyr  Gly Gly Ala 
    1070                 1075                 1080             


Tyr Thr  Ser Arg Asn His Gly  Tyr Gly Lys Ser Tyr  Glu Ser Asn 
    1085                 1090                 1095             


Ser Ser  Val Gln Ala Asp Tyr  Ala Ser Val Tyr Glu  Glu Lys Ala 
    1100                 1105                 1110             


Asp Thr  Asp Gly Arg Arg Asp  Asn His Cys Glu Ser  Asn Arg Gly 
    1115                 1120                 1125             


Tyr Gly  Asp Tyr Thr Pro Leu  Pro Ala Gly Tyr Val  Thr Lys Glu 
    1130                 1135                 1140             


Leu Glu  Tyr Phe Pro Glu Thr  Asp Lys Val Trp Val  Glu Ile Gly 
    1145                 1150                 1155             


Glu Thr  Glu Gly Thr Phe Ile  Val Asp Ser Val Glu  Leu Leu Leu 
    1160                 1165                 1170             


Met Glu  Glu 
    1175     


<210>  3
<211>  1854
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  mp372/cry1E chimera

<400>  3
atggagatag tgaataatca gaatcaatgc gtgccttata attgtttaaa taatcctgaa       60

aatgagatat tagatattga aaggtcaaat agtactgtag caacaaacat cgccttggag      120

attagtcgtc tgctcgcttc cgcaactcca atagggggga ttttattagg attgtttgat      180

gcaatatggg ggtctatagg cccttcacaa tgggatttat ttttagagca aattgagcta      240

ttgattgacc aaaaaataga ggaattcgct agaaaccagg caatttctag attggaaggg      300

ataagcagtc tgtacggaat ttatacagaa gcttttagag agtgggaagc agatcctact      360

aatccagcat taaaagaaga gatgcgtact caatttaatg acatgaacag tattcttgta      420

acagctattc ctcttttttc agttcaaaat tatcaagtcc catttttatc agtatatgtt      480

caagctgcaa atttacattt atcggttttg agagatgttt cagtgtttgg gcaggcttgg      540

ggatttgata tagcaacaat aaatagtcgt tataatgatc tgactagact tattcctata      600

tatacagatt atgctgtacg ctggtacaat acgggattag atcgcttacc acgaactggt      660

gggctgcgaa actgggcaag atttaatcag tttagaagag agttaacaat atcagtatta      720

gatattattt cttttttcag aaattacgat tctagattat atccaattcc aacaagctcc      780

caattaacgc gggaagtata tacagatccg gtaattaata taactgatta tagagttacc      840

ccaagtttcg agagtattga aaactcagcc attagaagcc cccatcttat ggatttctta      900

actaatataa ttattgacac tgatttaata agaggtgttt actattgggc aggacatcgt      960

ataaattctc gctttaccgg gaccgctttt ccacatataa taacatctcc tcaatatgga     1020

ataactgcaa acgcagaacc aagacgtaca atagcgcctg gtccttttca aggtgtgcct     1080

tccctacttt atagaacact atcagaccct ttcttccgaa gatcagacaa tattagtcca     1140

accttaggga taaatgtagt acagggggta gggttcttac aaccaaataa ttttgaatct     1200

ctatatagaa ggagagggac agtagattct ctcgatgagt tgccaattga tggtgaaaat     1260

ccattagttg gatatagtca tcgattaagt cacgttacat taaccaggtc attatttaat     1320

actaatataa ctagcctgcc aacatttgtt tggacacatc acagtgctac tgatacaaat     1380

acaattgctc cagatgtcat tacccaaata ccgttagtaa aggctttcaa tcttcattca     1440

ggtgccacgg ttgctagagg gccaggattt acaggtgggg atatccttcg aagaacgaat     1500

gttggtaact ttggagatat gcgtgtaaat attactgcac cactatcaca aagatatcga     1560

gtaaggattc gttatgcttc tactacaaat ttacgattcc atacatcaat taacggaaga     1620

gctattaatc aggcggattt tccagctact atgaatagtg ggggtaattt acagtccggt     1680

agcttcagga ttgcaggttt tactactcca tttacctttt cagatgcact aagcacattc     1740

acaataggtg cttttggctt ctcttcaggt aacgaagttt atatagatcg aattgaattt     1800

gttccggcag aagtaacctt tgaggcagaa tatgatctag aaagagcaca aaag           1854


<210>  4
<211>  618
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mp372/cry1E chimera

<400>  4

Met Glu Ile Val Asn Asn Gln Asn Gln Cys Val Pro Tyr Asn Cys Leu 
1               5                   10                  15      


Asn Asn Pro Glu Asn Glu Ile Leu Asp Ile Glu Arg Ser Asn Ser Thr 
            20                  25                  30          


Val Ala Thr Asn Ile Ala Leu Glu Ile Ser Arg Leu Leu Ala Ser Ala 
        35                  40                  45              


Thr Pro Ile Gly Gly Ile Leu Leu Gly Leu Phe Asp Ala Ile Trp Gly 
    50                  55                  60                  


Ser Ile Gly Pro Ser Gln Trp Asp Leu Phe Leu Glu Gln Ile Glu Leu 
65                  70                  75                  80  


Leu Ile Asp Gln Lys Ile Glu Glu Phe Ala Arg Asn Gln Ala Ile Ser 
                85                  90                  95      


Arg Leu Glu Gly Ile Ser Ser Leu Tyr Gly Ile Tyr Thr Glu Ala Phe 
            100                 105                 110         


Arg Glu Trp Glu Ala Asp Pro Thr Asn Pro Ala Leu Lys Glu Glu Met 
        115                 120                 125             


Arg Thr Gln Phe Asn Asp Met Asn Ser Ile Leu Val Thr Ala Ile Pro 
    130                 135                 140                 


Leu Phe Ser Val Gln Asn Tyr Gln Val Pro Phe Leu Ser Val Tyr Val 
145                 150                 155                 160 


Gln Ala Ala Asn Leu His Leu Ser Val Leu Arg Asp Val Ser Val Phe 
                165                 170                 175     


Gly Gln Ala Trp Gly Phe Asp Ile Ala Thr Ile Asn Ser Arg Tyr Asn 
            180                 185                 190         


Asp Leu Thr Arg Leu Ile Pro Ile Tyr Thr Asp Tyr Ala Val Arg Trp 
        195                 200                 205             


Tyr Asn Thr Gly Leu Asp Arg Leu Pro Arg Thr Gly Gly Leu Arg Asn 
    210                 215                 220                 


Trp Ala Arg Phe Asn Gln Phe Arg Arg Glu Leu Thr Ile Ser Val Leu 
225                 230                 235                 240 


Asp Ile Ile Ser Phe Phe Arg Asn Tyr Asp Ser Arg Leu Tyr Pro Ile 
                245                 250                 255     


Pro Thr Ser Ser Gln Leu Thr Arg Glu Val Tyr Thr Asp Pro Val Ile 
            260                 265                 270         


Asn Ile Thr Asp Tyr Arg Val Thr Pro Ser Phe Glu Ser Ile Glu Asn 
        275                 280                 285             


Ser Ala Ile Arg Ser Pro His Leu Met Asp Phe Leu Thr Asn Ile Ile 
    290                 295                 300                 


Ile Asp Thr Asp Leu Ile Arg Gly Val Tyr Tyr Trp Ala Gly His Arg 
305                 310                 315                 320 


Ile Asn Ser Arg Phe Thr Gly Thr Ala Phe Pro His Ile Ile Thr Ser 
                325                 330                 335     


Pro Gln Tyr Gly Ile Thr Ala Asn Ala Glu Pro Arg Arg Thr Ile Ala 
            340                 345                 350         


Pro Gly Pro Phe Gln Gly Val Pro Ser Leu Leu Tyr Arg Thr Leu Ser 
        355                 360                 365             


Asp Pro Phe Phe Arg Arg Ser Asp Asn Ile Ser Pro Thr Leu Gly Ile 
    370                 375                 380                 


Asn Val Val Gln Gly Val Gly Phe Leu Gln Pro Asn Asn Phe Glu Ser 
385                 390                 395                 400 


Leu Tyr Arg Arg Arg Gly Thr Val Asp Ser Leu Asp Glu Leu Pro Ile 
                405                 410                 415     


Asp Gly Glu Asn Pro Leu Val Gly Tyr Ser His Arg Leu Ser His Val 
            420                 425                 430         


Thr Leu Thr Arg Ser Leu Phe Asn Thr Asn Ile Thr Ser Leu Pro Thr 
        435                 440                 445             


Phe Val Trp Thr His His Ser Ala Thr Asp Thr Asn Thr Ile Ala Pro 
    450                 455                 460                 


Asp Val Ile Thr Gln Ile Pro Leu Val Lys Ala Phe Asn Leu His Ser 
465                 470                 475                 480 


Gly Ala Thr Val Ala Arg Gly Pro Gly Phe Thr Gly Gly Asp Ile Leu 
                485                 490                 495     


Arg Arg Thr Asn Val Gly Asn Phe Gly Asp Met Arg Val Asn Ile Thr 
            500                 505                 510         


Ala Pro Leu Ser Gln Arg Tyr Arg Val Arg Ile Arg Tyr Ala Ser Thr 
        515                 520                 525             


Thr Asn Leu Arg Phe His Thr Ser Ile Asn Gly Arg Ala Ile Asn Gln 
    530                 535                 540                 


Ala Asp Phe Pro Ala Thr Met Asn Ser Gly Gly Asn Leu Gln Ser Gly 
545                 550                 555                 560 


Ser Phe Arg Ile Ala Gly Phe Thr Thr Pro Phe Thr Phe Ser Asp Ala 
                565                 570                 575     


Leu Ser Thr Phe Thr Ile Gly Ala Phe Gly Phe Ser Ser Gly Asn Glu 
            580                 585                 590         


Val Tyr Ile Asp Arg Ile Glu Phe Val Pro Ala Glu Val Thr Phe Glu 
        595                 600                 605             


Ala Glu Tyr Asp Leu Glu Arg Ala Gln Lys 
    610                 615             


<210>  5
<211>  3526
<212>  DNA
<213>  Bacillus thuringiensis

<400>  5
atggagatag tgaataatca gaatcaatgc gtgccttata attgtttaaa taatcctgaa       60

aatgagatat tagatattga aaggtcaaat agtactgtag caacaaacat cgccttggag      120

attagtcgtc tgctcgcttc cgcaactcca atagggggga ttttattagg attgtttgat      180

gcaatatggg ggtctatagg cccttcacaa tgggatttat ttttagagca aattgagcta      240

ttgattgacc aaaaaataga ggaattcgct agaaaccagg caatttctag attggaaggg      300

ataagcagtc tgtacggaat ttatacagaa gcttttagag agtgggaagc agatcctact      360

aatccagcat taaaagaaga gatgcgtact caatttaatg acatgaacag tattcttgta      420

acagctattc ctcttttttc agttcaaaat tatcaagtcc catttttatc agtatatgtt      480

caagctgcaa atttacattt atcggttttg agagatgttt cagtgtttgg gcaggcttgg      540

ggatttgata tagcaacaat aaatagtcgt tataatgatc tgactagact tattcctata      600

tatacagatt atgctgtacg ctggtacaat acgggattag atcgcttacc acgaactggt      660

gggctgcgaa actgggcaag atttaatcag tttagaagag agttaacaat atcagtatta      720

gatattattt cttttttcag aaattacgat tctagattat atccaattcc aacaagctcc      780

caattaacgc gggaagtata tacagatccg gtaattaata taactgacta tagagttggc      840

cccagcttcg agaatattga gaactcagcc attagaagcc cccaccttat ggacttctta      900

aataatttga ccattgatac ggatttgatt agaggtgttc actattgggc agggcatcgt      960

gtaacttctc attttacagg tagttctcaa gtgataacaa cccctcaata tgggataacc     1020

gcaaatgcgg aaccaagacg aactattgct cctagtactt ttccaggtct taacctattt     1080

tatagaacat tatcaaatcc tttcttccga agatcagaaa atattactcc taccttaggg     1140

ataaatgtag tacagggagt agggttcatt caaccaaata atgctgaagt tctatataga     1200

agtaggggga cagtagattc tcttaatgag ttaccaattg atggtgagaa ttcattagtt     1260

ggatatagtc atcgattaag tcatgttaca ctaaccaggt cgttatataa tactaatata     1320

actagcctgc caacatttgt ttggacacat cacagtgcta ctaatacaaa tacaattaat     1380

ccagatatta ttacacaaat acctttagtg aaaggattta gacttggtgg tggcacctct     1440

gtcattaaag gaccaggatt tacaggaggg gatatccttc gaagaaatac cattggtgag     1500

tttgtgtctt tacaagtcaa tattaactca ccaattaccc aaagataccg tttaagattt     1560

cgttatgctt ccagtaggga tgcacgaatt actgtagcga taggaggaca aattagagta     1620

gatatgaccc ttgaaaaaac catggaaatt ggggagagct taacatctag aacatttagc     1680

tataccaatt ttagtaatcc tttttcattt agggctaatc cagatataat tagaatagct     1740

gaagaacttc ctattcgtgg tggtgagctt tatatagata aaattgaact tattctagca     1800

gatgcaacat ttgaagaaga atatgatttg gaaagagcac agaaggcggt gaatgccctg     1860

tttacttcta caaatcaact agggctaaaa acagatgtga cggattatca tattgatcaa     1920

gtttccaatt tagttgagtg tttatcggat gaattttgtc tggatgaaaa gagagaatta     1980

tccgagaaag tcaaacatgc gaagcgactc agtgatgaac ggaatttact tcaagatcca     2040

aacttcagag ggatcaatag gcaaccagac cgtggctgga gaggaagcac ggatattact     2100

atccaaggtg gagatgacgt attcaaagag aattacgtca cattaccggg tacctttgat     2160

gagtgctatc caacgtattt atatcaaaaa atagatgagt cgaagttaaa agcttatacc     2220

cgctatgaat taagagggta tatcgaggat agtcaagact tagaaatcta tttaattcgc     2280

tacaatgcaa aacacgagac agtaaacgtg ccaggtacgg gttccttatg gccgctttca     2340

gcccaaagtc caatcggaaa gtgtggagaa ccgaatcgat gcgcgccaca ccttgaatgg     2400

aatcctaatc tagattgctc ctgcagagac ggggaaaaat gtgcccatca ttcccatcat     2460

ttctccttgg acattgatgt tggatgtaca gacttaaatg aggacttagg tgtatgggtg     2520

atattcaaga ttaagacaca agatggctat gcaagactag gaaatctaga gtttctcgaa     2580

gagaacccac tattagggga agcactagct cgtgtgaaaa gagcggagaa aaaatggaga     2640

gacaaatgcg aaaaattgga atgggaaaca aatattgttt ataaagaggc aaaagaatct     2700

gtagatgctt tatttgtaaa ctctcaatat gatagattac aagcggatac gaatatcgcg     2760

atgattcatg cggcagataa acgcgttcat agcattcgag aagcgtatct gccagagctg     2820

tctgtgattc cgggtgtcaa tgcggctatt tttgaagaat tagaagggcg tattttcact     2880

gcattctccc tatatgatgc gagaaatgtc attaaaaatg gcgatttcaa taatggctta     2940

tcatgctgga acgtgaaagg gcatgtagat gtagaagaac agaacaacca tcgttcggtc     3000

cttgttgttc cagaatggga agcagaagtg tcacaagaag ttcgtgtttg tccgggtcgt     3060

ggctatatcc ttcgtgttac agcgtacaaa gagggatatg gagagggctg tgtaacgatt     3120

catgagatcg aagacaatac agacgaactg aaattcagca actgtgtaga agaggaagta     3180

tatccaaaca acacggtaac gtgtaataat tatactgcga ctcaagaaga acatgagggt     3240

acgtacactt cccgtaatcg aggatatgac gaagcctatg aaagcaattc ttctgtacat     3300

gcgtcagtct atgaagaaaa atcgtataca gatagacgaa gagagaatcc ttgtgaatct     3360

aacagaggat atggggatta cacaccacta ccagctggct atgtgacaaa agaattagag     3420

tacttcccag aaaccgataa ggtatggatt gagatcggag aaacggaagg aacattcatc     3480

gtggacagcg tggaattact tcttatggag gaataatata tgcttt                    3526


<210>  6
<211>  1171
<212>  PRT
<213>  Bacillus thuringiensis

<400>  6

Met Glu Ile Val Asn Asn Gln Asn Gln Cys Val Pro Tyr Asn Cys Leu 
1               5                   10                  15      


Asn Asn Pro Glu Asn Glu Ile Leu Asp Ile Glu Arg Ser Asn Ser Thr 
            20                  25                  30          


Val Ala Thr Asn Ile Ala Leu Glu Ile Ser Arg Leu Leu Ala Ser Ala 
        35                  40                  45              


Thr Pro Ile Gly Gly Ile Leu Leu Gly Leu Phe Asp Ala Ile Trp Gly 
    50                  55                  60                  


Ser Ile Gly Pro Ser Gln Trp Asp Leu Phe Leu Glu Gln Ile Glu Leu 
65                  70                  75                  80  


Leu Ile Asp Gln Lys Ile Glu Glu Phe Ala Arg Asn Gln Ala Ile Ser 
                85                  90                  95      


Arg Leu Glu Gly Ile Ser Ser Leu Tyr Gly Ile Tyr Thr Glu Ala Phe 
            100                 105                 110         


Arg Glu Trp Glu Ala Asp Pro Thr Asn Pro Ala Leu Lys Glu Glu Met 
        115                 120                 125             


Arg Thr Gln Phe Asn Asp Met Asn Ser Ile Leu Val Thr Ala Ile Pro 
    130                 135                 140                 


Leu Phe Ser Val Gln Asn Tyr Gln Val Pro Phe Leu Ser Val Tyr Val 
145                 150                 155                 160 


Gln Ala Ala Asn Leu His Leu Ser Val Leu Arg Asp Val Ser Val Phe 
                165                 170                 175     


Gly Gln Ala Trp Gly Phe Asp Ile Ala Thr Ile Asn Ser Arg Tyr Asn 
            180                 185                 190         


Asp Leu Thr Arg Leu Ile Pro Ile Tyr Thr Asp Tyr Ala Val Arg Trp 
        195                 200                 205             


Tyr Asn Thr Gly Leu Asp Arg Leu Pro Arg Thr Gly Gly Leu Arg Asn 
    210                 215                 220                 


Trp Ala Arg Phe Asn Gln Phe Arg Arg Glu Leu Thr Ile Ser Val Leu 
225                 230                 235                 240 


Asp Ile Ile Ser Phe Phe Arg Asn Tyr Asp Ser Arg Leu Tyr Pro Ile 
                245                 250                 255     


Pro Thr Ser Ser Gln Leu Thr Arg Glu Val Tyr Thr Asp Pro Val Ile 
            260                 265                 270         


Asn Ile Thr Asp Tyr Arg Val Gly Pro Ser Phe Glu Asn Ile Glu Asn 
        275                 280                 285             


Ser Ala Ile Arg Ser Pro His Leu Met Asp Phe Leu Asn Asn Leu Thr 
    290                 295                 300                 


Ile Asp Thr Asp Leu Ile Arg Gly Val His Tyr Trp Ala Gly His Arg 
305                 310                 315                 320 


Val Thr Ser His Phe Thr Gly Ser Ser Gln Val Ile Thr Thr Pro Gln 
                325                 330                 335     


Tyr Gly Ile Thr Ala Asn Ala Glu Pro Arg Arg Thr Ile Ala Pro Ser 
            340                 345                 350         


Thr Phe Pro Gly Leu Asn Leu Phe Tyr Arg Thr Leu Ser Asn Pro Phe 
        355                 360                 365             


Phe Arg Arg Ser Glu Asn Ile Thr Pro Thr Leu Gly Ile Asn Val Val 
    370                 375                 380                 


Gln Gly Val Gly Phe Ile Gln Pro Asn Asn Ala Glu Val Leu Tyr Arg 
385                 390                 395                 400 


Ser Arg Gly Thr Val Asp Ser Leu Asn Glu Leu Pro Ile Asp Gly Glu 
                405                 410                 415     


Asn Ser Leu Val Gly Tyr Ser His Arg Leu Ser His Val Thr Leu Thr 
            420                 425                 430         


Arg Ser Leu Tyr Asn Thr Asn Ile Thr Ser Leu Pro Thr Phe Val Trp 
        435                 440                 445             


Thr His His Ser Ala Thr Asn Thr Asn Thr Ile Asn Pro Asp Ile Ile 
    450                 455                 460                 


Thr Gln Ile Pro Leu Val Lys Gly Phe Arg Leu Gly Gly Gly Thr Ser 
465                 470                 475                 480 


Val Ile Lys Gly Pro Gly Phe Thr Gly Gly Asp Ile Leu Arg Arg Asn 
                485                 490                 495     


Thr Ile Gly Glu Phe Val Ser Leu Gln Val Asn Ile Asn Ser Pro Ile 
            500                 505                 510         


Thr Gln Arg Tyr Arg Leu Arg Phe Arg Tyr Ala Ser Ser Arg Asp Ala 
        515                 520                 525             


Arg Ile Thr Val Ala Ile Gly Gly Gln Ile Arg Val Asp Met Thr Leu 
    530                 535                 540                 


Glu Lys Thr Met Glu Ile Gly Glu Ser Leu Thr Ser Arg Thr Phe Ser 
545                 550                 555                 560 


Tyr Thr Asn Phe Ser Asn Pro Phe Ser Phe Arg Ala Asn Pro Asp Ile 
                565                 570                 575     


Ile Arg Ile Ala Glu Glu Leu Pro Ile Arg Gly Gly Glu Leu Tyr Ile 
            580                 585                 590         


Asp Lys Ile Glu Leu Ile Leu Ala Asp Ala Thr Phe Glu Glu Glu Tyr 
        595                 600                 605             


Asp Leu Glu Arg Ala Gln Lys Ala Val Asn Ala Leu Phe Thr Ser Thr 
    610                 615                 620                 


Asn Gln Leu Gly Leu Lys Thr Asp Val Thr Asp Tyr His Ile Asp Gln 
625                 630                 635                 640 


Val Ser Asn Leu Val Glu Cys Leu Ser Asp Glu Phe Cys Leu Asp Glu 
                645                 650                 655     


Lys Arg Glu Leu Ser Glu Lys Val Lys His Ala Lys Arg Leu Ser Asp 
            660                 665                 670         


Glu Arg Asn Leu Leu Gln Asp Pro Asn Phe Arg Gly Ile Asn Arg Gln 
        675                 680                 685             


Pro Asp Arg Gly Trp Arg Gly Ser Thr Asp Ile Thr Ile Gln Gly Gly 
    690                 695                 700                 


Asp Asp Val Phe Lys Glu Asn Tyr Val Thr Leu Pro Gly Thr Phe Asp 
705                 710                 715                 720 


Glu Cys Tyr Pro Thr Tyr Leu Tyr Gln Lys Ile Asp Glu Ser Lys Leu 
                725                 730                 735     


Lys Ala Tyr Thr Arg Tyr Glu Leu Arg Gly Tyr Ile Glu Asp Ser Gln 
            740                 745                 750         


Asp Leu Glu Ile Tyr Leu Ile Arg Tyr Asn Ala Lys His Glu Thr Val 
        755                 760                 765             


Asn Val Pro Gly Thr Gly Ser Leu Trp Pro Leu Ser Ala Gln Ser Pro 
    770                 775                 780                 


Ile Gly Lys Cys Gly Glu Pro Asn Arg Cys Ala Pro His Leu Glu Trp 
785                 790                 795                 800 


Asn Pro Asn Leu Asp Cys Ser Cys Arg Asp Gly Glu Lys Cys Ala His 
                805                 810                 815     


His Ser His His Phe Ser Leu Asp Ile Asp Val Gly Cys Thr Asp Leu 
            820                 825                 830         


Asn Glu Asp Leu Gly Val Trp Val Ile Phe Lys Ile Lys Thr Gln Asp 
        835                 840                 845             


Gly Tyr Ala Arg Leu Gly Asn Leu Glu Phe Leu Glu Glu Asn Pro Leu 
    850                 855                 860                 


Leu Gly Glu Ala Leu Ala Arg Val Lys Arg Ala Glu Lys Lys Trp Arg 
865                 870                 875                 880 


Asp Lys Cys Glu Lys Leu Glu Trp Glu Thr Asn Ile Val Tyr Lys Glu 
                885                 890                 895     


Ala Lys Glu Ser Val Asp Ala Leu Phe Val Asn Ser Gln Tyr Asp Arg 
            900                 905                 910         


Leu Gln Ala Asp Thr Asn Ile Ala Met Ile His Ala Ala Asp Lys Arg 
        915                 920                 925             


Val His Ser Ile Arg Glu Ala Tyr Leu Pro Glu Leu Ser Val Ile Pro 
    930                 935                 940                 


Gly Val Asn Ala Ala Ile Phe Glu Glu Leu Glu Gly Arg Ile Phe Thr 
945                 950                 955                 960 


Ala Phe Ser Leu Tyr Asp Ala Arg Asn Val Ile Lys Asn Gly Asp Phe 
                965                 970                 975     


Asn Asn Gly Leu Ser Cys Trp Asn Val Lys Gly His Val Asp Val Glu 
            980                 985                 990         


Glu Gln Asn Asn His Arg Ser Val  Leu Val Val Pro Glu  Trp Glu Ala 
        995                 1000                 1005             


Glu Val  Ser Gln Glu Val Arg  Val Cys Pro Gly Arg  Gly Tyr Ile 
    1010                 1015                 1020             


Leu Arg  Val Thr Ala Tyr Lys  Glu Gly Tyr Gly Glu  Gly Cys Val 
    1025                 1030                 1035             


Thr Ile  His Glu Ile Glu Asp  Asn Thr Asp Glu Leu  Lys Phe Ser 
    1040                 1045                 1050             


Asn Cys  Val Glu Glu Glu Val  Tyr Pro Asn Asn Thr  Val Thr Cys 
    1055                 1060                 1065             


Asn Asn  Tyr Thr Ala Thr Gln  Glu Glu His Glu Gly  Thr Tyr Thr 
    1070                 1075                 1080             


Ser Arg  Asn Arg Gly Tyr Asp  Glu Ala Tyr Glu Ser  Asn Ser Ser 
    1085                 1090                 1095             


Val His  Ala Ser Val Tyr Glu  Glu Lys Ser Tyr Thr  Asp Arg Arg 
    1100                 1105                 1110             


Arg Glu  Asn Pro Cys Glu Ser  Asn Arg Gly Tyr Gly  Asp Tyr Thr 
    1115                 1120                 1125             


Pro Leu  Pro Ala Gly Tyr Val  Thr Lys Glu Leu Glu  Tyr Phe Pro 
    1130                 1135                 1140             


Glu Thr  Asp Lys Val Trp Ile  Glu Ile Gly Glu Thr  Glu Gly Thr 
    1145                 1150                 1155             


Phe Ile  Val Asp Ser Val Glu  Leu Leu Leu Met Glu  Glu 
    1160                 1165                 1170     


<210>  7
<211>  1171
<212>  PRT
<213>  Bacillus thuringiensis

<400>  7

Met Glu Ile Val Asn Asn Gln Asn Gln Cys Val Pro Tyr Asn Cys Leu 
1               5                   10                  15      


Asn Asn Pro Glu Asn Glu Ile Leu Asp Ile Glu Arg Ser Asn Ser Thr 
            20                  25                  30          


Val Ala Thr Asn Ile Ala Leu Glu Ile Ser Arg Leu Leu Ala Ser Ala 
        35                  40                  45              


Thr Pro Ile Gly Gly Ile Leu Leu Gly Leu Phe Asp Ala Ile Trp Gly 
    50                  55                  60                  


Ser Ile Gly Pro Ser Gln Trp Asp Leu Phe Leu Glu Gln Ile Glu Leu 
65                  70                  75                  80  


Leu Ile Asp Gln Lys Ile Glu Glu Phe Ala Arg Asn Gln Ala Ile Ser 
                85                  90                  95      


Arg Leu Glu Gly Ile Ser Ser Leu Tyr Gly Ile Tyr Thr Glu Ala Phe 
            100                 105                 110         


Arg Glu Trp Glu Ala Asp Pro Thr Asn Pro Ala Leu Lys Glu Glu Met 
        115                 120                 125             


Arg Thr Gln Phe Asn Asp Met Asn Ser Ile Leu Val Thr Ala Ile Pro 
    130                 135                 140                 


Leu Phe Ser Val Gln Asn Tyr Gln Val Pro Phe Leu Ser Val Tyr Val 
145                 150                 155                 160 


Gln Ala Ala Asn Leu His Leu Ser Val Leu Arg Asp Val Ser Val Phe 
                165                 170                 175     


Gly Gln Ala Trp Gly Phe Asp Ile Ala Thr Ile Asn Ser Arg Tyr Asn 
            180                 185                 190         


Asp Leu Thr Arg Leu Ile Pro Ile Tyr Thr Asp Tyr Ala Val Arg Trp 
        195                 200                 205             


Tyr Asn Thr Gly Leu Asp Arg Leu Pro Arg Thr Gly Gly Leu Arg Asn 
    210                 215                 220                 


Trp Ala Arg Phe Asn Gln Phe Arg Arg Glu Leu Thr Ile Ser Val Leu 
225                 230                 235                 240 


Asp Ile Ile Ser Phe Phe Arg Asn Tyr Asp Ser Arg Leu Tyr Pro Ile 
                245                 250                 255     


Pro Thr Ser Ser Gln Leu Thr Arg Glu Val Tyr Thr Asp Pro Val Ile 
            260                 265                 270         


Asn Ile Thr Asp Tyr Arg Val Gly Pro Ser Phe Glu Asn Ile Glu Asn 
        275                 280                 285             


Ser Ala Ile Arg Ser Pro His Leu Met Asp Phe Leu Asn Asn Leu Thr 
    290                 295                 300                 


Ile Asp Thr Asp Leu Ile Arg Gly Val His Tyr Trp Ala Gly His Arg 
305                 310                 315                 320 


Val Thr Ser His Phe Thr Gly Ser Ser Gln Val Ile Thr Thr Pro Gln 
                325                 330                 335     


Tyr Gly Ile Thr Ala Asn Ala Glu Pro Arg Arg Thr Ile Ala Pro Ser 
            340                 345                 350         


Thr Phe Pro Gly Leu Asn Leu Phe Tyr Arg Thr Leu Ser Asn Pro Phe 
        355                 360                 365             


Phe Arg Arg Ser Glu Asn Ile Thr Pro Thr Leu Gly Ile Asn Val Val 
    370                 375                 380                 


Gln Gly Val Gly Phe Ile Gln Pro Asn Asn Ala Glu Val Leu Tyr Arg 
385                 390                 395                 400 


Ser Arg Gly Thr Val Asp Ser Leu Asn Glu Leu Pro Ile Asp Gly Glu 
                405                 410                 415     


Asn Ser Leu Val Gly Tyr Ser His Arg Leu Ser His Val Thr Leu Thr 
            420                 425                 430         


Arg Ser Leu Tyr Asn Thr Asn Ile Thr Ser Leu Pro Thr Phe Val Trp 
        435                 440                 445             


Thr His His Ser Ala Thr Asn Thr Asn Thr Ile Asn Pro Asp Ile Ile 
    450                 455                 460                 


Thr Gln Ile Pro Leu Val Lys Gly Phe Arg Leu Gly Gly Gly Thr Ser 
465                 470                 475                 480 


Val Ile Lys Gly Pro Gly Phe Thr Gly Gly Asp Ile Leu Arg Arg Asn 
                485                 490                 495     


Thr Ile Gly Glu Phe Val Ser Leu Gln Val Asn Ile Asn Ser Pro Ile 
            500                 505                 510         


Thr Gln Arg Tyr Arg Leu Arg Phe Arg Tyr Ala Ser Ser Arg Asp Ala 
        515                 520                 525             


Arg Ile Thr Val Ala Ile Gly Gly Gln Ile Arg Val Asp Met Thr Leu 
    530                 535                 540                 


Glu Lys Thr Met Glu Ile Gly Glu Ser Leu Thr Ser Arg Thr Phe Ser 
545                 550                 555                 560 


Tyr Thr Asn Phe Ser Asn Pro Phe Ser Phe Arg Ala Asn Pro Asp Ile 
                565                 570                 575     


Ile Arg Ile Ala Glu Glu Leu Pro Ile Arg Gly Gly Glu Leu Tyr Ile 
            580                 585                 590         


Asp Lys Ile Glu Leu Ile Leu Ala Asp Ala Thr Phe Glu Glu Glu Tyr 
        595                 600                 605             


Asp Leu Glu Arg Ala Gln Lys Ala Val Asn Ala Leu Phe Thr Ser Thr 
    610                 615                 620                 


Asn Gln Leu Gly Leu Lys Thr Asp Val Thr Asp Tyr His Ile Asp Gln 
625                 630                 635                 640 


Val Ser Asn Leu Val Glu Cys Leu Ser Asp Glu Phe Cys Leu Asp Glu 
                645                 650                 655     


Lys Arg Glu Leu Ser Glu Lys Val Lys His Ala Lys Arg Leu Ser Asp 
            660                 665                 670         


Glu Arg Asn Leu Leu Gln Asp Pro Asn Phe Arg Gly Ile Asn Arg Gln 
        675                 680                 685             


Pro Asp Arg Gly Trp Arg Gly Ser Thr Asp Ile Thr Ile Gln Gly Gly 
    690                 695                 700                 


Asp Asp Val Phe Lys Glu Asn Tyr Val Thr Leu Pro Gly Thr Phe Asp 
705                 710                 715                 720 


Glu Cys Tyr Pro Thr Tyr Leu Tyr Gln Lys Ile Asp Glu Ser Lys Leu 
                725                 730                 735     


Lys Ala Tyr Thr Arg Tyr Glu Leu Arg Gly Tyr Ile Glu Asp Ser Gln 
            740                 745                 750         


Asp Leu Glu Ile Tyr Leu Ile Arg Tyr Asn Ala Lys His Glu Thr Val 
        755                 760                 765             


Asn Val Pro Gly Thr Gly Ser Leu Trp Pro Leu Ser Ala Gln Ser Pro 
    770                 775                 780                 


Ile Gly Lys Cys Gly Glu Pro Asn Arg Cys Ala Pro His Leu Glu Trp 
785                 790                 795                 800 


Asn Pro Asn Leu Asp Cys Ser Cys Arg Asp Gly Glu Lys Cys Ala His 
                805                 810                 815     


His Ser His His Phe Ser Leu Asp Ile Asp Val Gly Cys Thr Asp Leu 
            820                 825                 830         


Asn Glu Asp Leu Gly Val Trp Val Ile Phe Lys Ile Lys Thr Gln Asp 
        835                 840                 845             


Gly Tyr Ala Arg Leu Gly Asn Leu Glu Phe Leu Glu Glu Lys Pro Leu 
    850                 855                 860                 


Leu Gly Glu Ala Leu Ala Arg Val Lys Arg Ala Glu Lys Lys Trp Arg 
865                 870                 875                 880 


Asp Lys Cys Glu Lys Leu Glu Trp Glu Thr Asn Ile Val Tyr Lys Glu 
                885                 890                 895     


Ala Lys Glu Ser Val Asp Ala Leu Phe Val Asn Ser Gln Tyr Asp Arg 
            900                 905                 910         


Leu Gln Ala Asp Thr Asn Ile Ala Met Ile His Ala Ala Asp Lys Arg 
        915                 920                 925             


Val His Ser Ile Arg Glu Ala Tyr Leu Pro Glu Leu Ser Val Ile Pro 
    930                 935                 940                 


Gly Val Asn Ala Ala Ile Phe Glu Glu Leu Glu Gly Arg Ile Phe Thr 
945                 950                 955                 960 


Ala Phe Ser Leu Tyr Asp Ala Arg Asn Val Ile Lys Asn Gly Asp Phe 
                965                 970                 975     


Asn Asn Gly Leu Ser Cys Trp Asn Val Lys Gly His Val Asp Val Glu 
            980                 985                 990         


Glu Gln Asn Asn His Arg Ser Val  Leu Val Val Pro Glu  Trp Glu Ala 
        995                 1000                 1005             


Glu Val  Ser Gln Glu Val Arg  Val Cys Pro Gly Arg  Gly Tyr Ile 
    1010                 1015                 1020             


Leu Arg  Val Thr Ala Tyr Lys  Glu Gly Tyr Gly Glu  Gly Cys Val 
    1025                 1030                 1035             


Thr Ile  His Glu Ile Glu Asp  Asn Thr Asp Glu Leu  Lys Phe Ser 
    1040                 1045                 1050             


Asn Cys  Val Glu Glu Glu Val  Tyr Pro Asn Asn Thr  Val Thr Cys 
    1055                 1060                 1065             


Asn Asn  Tyr Thr Ala Thr Gln  Glu Glu His Glu Gly  Thr Tyr Thr 
    1070                 1075                 1080             


Ser Arg  Asn Arg Gly Tyr Asp  Glu Ala Tyr Glu Ser  Asn Ser Ser 
    1085                 1090                 1095             


Val His  Ala Ser Val Tyr Glu  Glu Lys Ser Tyr Thr  Asp Arg Arg 
    1100                 1105                 1110             


Arg Glu  Asn Pro Cys Glu Ser  Asn Arg Gly Tyr Gly  Asp Tyr Thr 
    1115                 1120                 1125             


Pro Leu  Pro Ala Gly Tyr Val  Thr Lys Glu Leu Glu  Tyr Phe Pro 
    1130                 1135                 1140             


Glu Thr  Asp Lys Val Trp Ile  Glu Ile Gly Glu Thr  Glu Gly Thr 
    1145                 1150                 1155             


Phe Ile  Val Asp Ser Val Glu  Leu Leu Leu Met Glu  Glu 
    1160                 1165                 1170     


