                         SEQUENCE LISTING

<110>  Novelogics Biotechnology, Inc.
 
<120>  Antibodies to MICA and MICB Proteins

<130>  NBI-003WO

<150>  62/410,282
<151>  2016-10-19

<160>  53    

<170>  PatentIn version 3.5

<210>  1
<211>  383
<212>  PRT
<213>  Homo sapiens

<400>  1

Met Gly Leu Gly Pro Val Phe Leu Leu Leu Ala Gly Ile Phe Pro Phe 
1               5                   10                  15      


Ala Pro Pro Gly Ala Ala Ala Glu Pro His Ser Leu Arg Tyr Asn Leu 
            20                  25                  30          


Thr Val Leu Ser Trp Asp Gly Ser Val Gln Ser Gly Phe Leu Thr Glu 
        35                  40                  45              


Val His Leu Asp Gly Gln Pro Phe Leu Arg Cys Asp Arg Gln Lys Cys 
    50                  55                  60                  


Arg Ala Lys Pro Gln Gly Gln Trp Ala Glu Asp Val Leu Gly Asn Lys 
65                  70                  75                  80  


Thr Trp Asp Arg Glu Thr Arg Asp Leu Thr Gly Asn Gly Lys Asp Leu 
                85                  90                  95      


Arg Met Thr Leu Ala His Ile Lys Asp Gln Lys Glu Gly Leu His Ser 
            100                 105                 110         


Leu Gln Glu Ile Arg Val Cys Glu Ile His Glu Asp Asn Ser Thr Arg 
        115                 120                 125             


Ser Ser Gln His Phe Tyr Tyr Asp Gly Glu Leu Phe Leu Ser Gln Asn 
    130                 135                 140                 


Leu Glu Thr Lys Glu Trp Thr Met Pro Gln Ser Ser Arg Ala Gln Thr 
145                 150                 155                 160 


Leu Ala Met Asn Val Arg Asn Phe Leu Lys Glu Asp Ala Met Lys Thr 
                165                 170                 175     


Lys Thr His Tyr His Ala Met His Ala Asp Cys Leu Gln Glu Leu Arg 
            180                 185                 190         


Arg Tyr Leu Lys Ser Gly Val Val Leu Arg Arg Thr Val Pro Pro Met 
        195                 200                 205             


Val Asn Val Thr Arg Ser Glu Ala Ser Glu Gly Asn Ile Thr Val Thr 
    210                 215                 220                 


Cys Arg Ala Ser Gly Phe Tyr Pro Trp Asn Ile Thr Leu Ser Trp Arg 
225                 230                 235                 240 


Gln Asp Gly Val Ser Leu Ser His Asp Thr Gln Gln Trp Gly Asp Val 
                245                 250                 255     


Leu Pro Asp Gly Asn Gly Thr Tyr Gln Thr Trp Val Ala Thr Arg Ile 
            260                 265                 270         


Cys Gln Gly Glu Glu Gln Arg Phe Thr Cys Tyr Met Glu His Ser Gly 
        275                 280                 285             


Asn His Ser Thr His Pro Val Pro Ser Gly Lys Val Leu Val Leu Gln 
    290                 295                 300                 


Ser His Trp Gln Thr Phe His Val Ser Ala Val Ala Ala Ala Ala Ile 
305                 310                 315                 320 


Phe Val Ile Ile Ile Phe Tyr Val Arg Cys Cys Lys Lys Lys Thr Ser 
                325                 330                 335     


Ala Ala Glu Gly Pro Glu Leu Val Ser Leu Gln Val Leu Asp Gln His 
            340                 345                 350         


Pro Val Gly Thr Ser Asp His Arg Asp Ala Thr Gln Leu Gly Phe Gln 
        355                 360                 365             


Pro Leu Met Ser Asp Leu Gly Ser Thr Gly Ser Thr Glu Gly Ala 
    370                 375                 380             


<210>  2
<211>  383
<212>  PRT
<213>  Homo sapiens

<400>  2

Met Gly Leu Gly Arg Val Leu Leu Phe Leu Ala Val Ala Phe Pro Phe 
1               5                   10                  15      


Ala Pro Pro Ala Ala Ala Ala Glu Pro His Ser Leu Arg Tyr Asn Leu 
            20                  25                  30          


Met Val Leu Ser Gln Asp Glu Ser Val Gln Ser Gly Phe Leu Ala Glu 
        35                  40                  45              


Gly His Leu Asp Gly Gln Pro Phe Leu Arg Tyr Asp Arg Gln Lys Arg 
    50                  55                  60                  


Arg Ala Lys Pro Gln Gly Gln Trp Ala Glu Asp Val Leu Gly Ala Lys 
65                  70                  75                  80  


Thr Trp Asp Thr Glu Thr Glu Asp Leu Thr Glu Asn Gly Gln Asp Leu 
                85                  90                  95      


Arg Arg Thr Leu Thr His Ile Lys Asp Gln Lys Gly Gly Leu His Ser 
            100                 105                 110         


Leu Gln Glu Ile Arg Val Cys Glu Ile His Glu Asp Ser Ser Thr Arg 
        115                 120                 125             


Gly Ser Arg His Phe Tyr Tyr Asp Gly Glu Leu Phe Leu Ser Gln Asn 
    130                 135                 140                 


Leu Glu Thr Gln Glu Ser Thr Val Pro Gln Ser Ser Arg Ala Gln Thr 
145                 150                 155                 160 


Leu Ala Met Asn Val Thr Asn Phe Trp Lys Glu Asp Ala Met Lys Thr 
                165                 170                 175     


Lys Thr His Tyr Arg Ala Met Gln Ala Asp Cys Leu Gln Lys Leu Gln 
            180                 185                 190         


Arg Tyr Leu Lys Ser Gly Val Ala Ile Arg Arg Thr Val Pro Pro Met 
        195                 200                 205             


Val Asn Val Thr Cys Ser Glu Val Ser Glu Gly Asn Ile Thr Val Thr 
    210                 215                 220                 


Cys Arg Ala Ser Ser Phe Tyr Pro Arg Asn Ile Thr Leu Thr Trp Arg 
225                 230                 235                 240 


Gln Asp Gly Val Ser Leu Ser His Asn Thr Gln Gln Trp Gly Asp Val 
                245                 250                 255     


Leu Pro Asp Gly Asn Gly Thr Tyr Gln Thr Trp Val Ala Thr Arg Ile 
            260                 265                 270         


Arg Gln Gly Glu Glu Gln Arg Phe Thr Cys Tyr Met Glu His Ser Gly 
        275                 280                 285             


Asn His Gly Thr His Pro Val Pro Ser Gly Lys Val Leu Val Leu Gln 
    290                 295                 300                 


Ser Gln Arg Thr Asp Phe Pro Tyr Val Ser Ala Ala Met Pro Cys Phe 
305                 310                 315                 320 


Val Ile Ile Ile Ile Leu Cys Val Pro Cys Cys Lys Lys Lys Thr Ser 
                325                 330                 335     


Ala Ala Glu Gly Pro Glu Leu Val Ser Leu Gln Val Leu Asp Gln His 
            340                 345                 350         


Pro Val Gly Thr Gly Asp His Arg Asp Ala Ala Gln Leu Gly Phe Gln 
        355                 360                 365             


Pro Leu Met Ser Ala Thr Gly Ser Thr Gly Ser Thr Glu Gly Ala 
    370                 375                 380             


<210>  3
<211>  93
<212>  PRT
<213>  Homo sapiens

<400>  3

Val Pro Pro Met Val Asn Val Thr Arg Ser Glu Ala Ser Glu Gly Asn 
1               5                   10                  15      


Ile Thr Val Thr Cys Arg Ala Ser Gly Phe Tyr Pro Trp Asn Ile Thr 
            20                  25                  30          


Leu Ser Trp Arg Gln Asp Gly Val Ser Leu Ser His Asp Thr Gln Gln 
        35                  40                  45              


Trp Gly Asp Val Leu Pro Asp Gly Asn Gly Thr Tyr Gln Thr Trp Val 
    50                  55                  60                  


Ala Thr Arg Ile Cys Gln Gly Glu Glu Gln Arg Phe Thr Cys Tyr Met 
65                  70                  75                  80  


Glu His Ser Gly Asn His Ser Thr His Pro Val Pro Ser 
                85                  90              


<210>  4
<211>  93
<212>  PRT
<213>  Homo sapiens

<400>  4

Val Pro Pro Met Val Asn Val Thr Cys Ser Glu Val Ser Glu Gly Asn 
1               5                   10                  15      


Ile Thr Val Thr Cys Arg Ala Ser Ser Phe Tyr Pro Arg Asn Ile Thr 
            20                  25                  30          


Leu Thr Trp Arg Gln Asp Gly Val Ser Leu Ser His Asn Thr Gln Gln 
        35                  40                  45              


Trp Gly Asp Val Leu Pro Asp Gly Asn Gly Thr Tyr Gln Thr Trp Val 
    50                  55                  60                  


Ala Thr Arg Ile Arg Gln Gly Glu Glu Gln Arg Phe Thr Cys Tyr Met 
65                  70                  75                  80  


Glu His Ser Gly Asn His Gly Thr His Pro Val Pro Ser 
                85                  90              


<210>  5
<211>  1365
<212>  DNA
<213>  Homo sapiens

<400>  5
cactgcttga gccgctgaga gggtggcgac gtcggggcca tggggctggg cccggtcttc       60

ctgcttctgg ctggcatctt cccttttgca cctccgggag ctgctgctga gccccacagt      120

cttcgttata acctcacggt gctgtcctgg gatggatctg tgcagtcagg gtttctcact      180

gaggtacatc tggatggtca gcccttcctg cgctgtgaca ggcagaaatg cagggcaaag      240

ccccagggac agtgggcaga agatgtcctg ggaaataaga catgggacag agagaccaga      300

gacttgacag ggaacggaaa ggacctcagg atgaccctgg ctcatatcaa ggaccagaaa      360

gaaggcttgc attccctcca ggagattagg gtctgtgaga tccatgaaga caacagcacc      420

aggagctccc agcatttcta ctacgatggg gagctcttcc tctcccaaaa cctggagact      480

aaggaatgga caatgcccca gtcctccaga gctcagacct tggccatgaa cgtcaggaat      540

ttcttgaagg aagatgccat gaagaccaag acacactatc acgctatgca tgcagactgc      600

ctgcaggaac tacggcgata tctaaaatcc ggcgtagtcc tgaggagaac agtgcccccc      660

atggtgaatg tcacccgcag cgaggcctca gagggcaaca ttaccgtgac atgcagggct      720

tctggcttct atccctggaa tatcacactg agctggcgtc aggatggggt atctttgagc      780

cacgacaccc agcagtgggg ggatgtcctg cctgatggga atggaaccta ccagacctgg      840

gtggccacca ggatttgcca aggagaggag cagaggttca cctgctacat ggaacacagc      900

gggaatcaca gcactcaccc tgtgccctct gggaaagtgc tggtgcttca gagtcattgg      960

cagacattcc atgtttctgc tgttgctgct gctgctattt ttgttattat tattttctat     1020

gtccgttgtt gtaagaagaa aacatcagct gcagagggtc cagagctcgt gagcctgcag     1080

gtcctggatc aacacccagt tgggacgagt gaccacaggg atgccacaca gctcggattt     1140

cagcctctga tgtcagatct tgggtccact ggctccactg agggcgccta gactctacag     1200

ccaggcagct gggattcaat tccctgcctg gatctcacga gcactttccc tcttggtgcc     1260

tcagtttcct gacctatgaa acagagaaaa taaaagcact tatttattgt tgttggaggc     1320

tgcaaaatgt tagtagatat gaggcgtttg cagctgtacc atatt                     1365


<210>  6
<211>  2380
<212>  DNA
<213>  Homo sapiens

<400>  6
gggccatggg gctgggccgg gtcctgctgt ttctggccgt cgccttccct tttgcacccc       60

cggcagccgc cgctgagccc cacagtcttc gttacaacct catggtgctg tcccaggatg      120

aatctgtgca gtcagggttt ctcgctgagg gacatctgga tggtcagccc ttcctgcgct      180

atgacaggca gaaacgcagg gcaaagcccc agggacagtg ggcagaagat gtcctgggag      240

ctaagacctg ggacacagag accgaggact tgacagagaa tgggcaagac ctcaggagga      300

ccctgactca tatcaaggac cagaaaggag gcttgcattc cctccaggag attagggtct      360

gtgagatcca tgaagacagc agcaccaggg gctcccggca tttctactac gatggggagc      420

tcttcctctc ccaaaacctg gagactcaag aatcgacagt gccccagtcc tccagagctc      480

agaccttggc tatgaacgtc acaaatttct ggaaggaaga tgccatgaag accaagacac      540

actatcgcgc tatgcaggca gactgcctgc agaaactaca gcgatatctg aaatccgggg      600

tggccatcag gagaacagtg ccccccatgg tgaatgtcac ctgcagcgag gtctcagagg      660

gcaacatcac cgtgacatgc agggcttcca gcttctatcc ccggaatatc acactgacct      720

ggcgtcagga tggggtatct ttgagccaca acacccagca gtggggggat gtcctgcctg      780

atgggaatgg aacctaccag acctgggtgg ccaccaggat tcgccaagga gaggagcaga      840

ggttcacctg ctacatggaa cacagcggga atcacggcac tcaccctgtg ccctctggga      900

aggtgctggt gcttcagagt caacggacag actttccata tgtttctgct gctatgccat      960

gttttgttat tattattatt ctctgtgtcc cttgttgcaa gaagaaaaca tcagcggcag     1020

agggtccaga gcttgtgagc ctgcaggtcc tggatcaaca cccagttggg acaggagacc     1080

acagggatgc agcacagctg ggatttcagc ctctgatgtc agctactggg tccactggtt     1140

ccactgaggg cgcctagact ctacagccag gcggccagga ttcaactccc tgcctggatc     1200

tcaccagcac tttccctctg tttcctgacc tatgaaacag aaaataacat cacttattta     1260

ttgttgttgg atgctgcaaa gtgttagtag gtatgaggtg tttgctgctc tgccacgtag     1320

agagccagca aagggatcat gaccaactca acattccatt ggaggctata tgatcaaaca     1380

gcaaattgtt tatcatgaat gcaggatgtg ggcaaactca cgactgctcc tgccaacaga     1440

aggtttgctg agggcattca ctccatggtg ctcattggag ttatctactg ggtcatctag     1500

agcctattgt ttgaggaatg cagtcttaca agcctactct ggacccagca gctgactcct     1560

tcttccaccc ctcttcttgc tatctcctat accaataaat acgaagggct gtggaagatc     1620

agagcccttg ttcacgagaa gcaagaagcc ccctgacccc ttgttccaaa tatactcttt     1680

tgtctttctc tttattccca cgttcgccct ttgttcagtc caatacaggg ttgtggggcc     1740

cttaacagtg ccatattaat tggtatcatt atttctgttg tttttgtttt tgtttttgtt     1800

tttgtttttg agacagagtc tcactcgtca cccaggctgc agttcactgg tgtgatctca     1860

gctcactgca acctctgcct cccaggttca agcacttctc gtacctcaga ctcccgatag     1920

ctgggattac agacaggcac caccacaccc agctaatttt tgtatttttt gtagagacgg     1980

ggtttcgcca agttgaccag cccagtttca aactcctgac ctcaggtgat ctgcctgcct     2040

tggcatccca aagtgctggg attacaagaa tgagccaccg tgcctggcct attttattat     2100

attgtaatat attttattat attagccacc atgcctgtcc tattttctta tgttttaata     2160

tattttaata tattacatgt gcagtaatta gattatcatg ggtgaacttt atgagtgagt     2220

atcttggtga tgactcctcc tgaccagccc aggaccagct ttcttgtcac cttgaggtcc     2280

cctcgccccg tcacaccgtt atcgattact ctgtgtctac tattatgtgt gcataattta     2340

taccgtaaat gtttactctt taaataaaaa aaaaaaaaaa                           2380


<210>  7
<211>  274
<212>  PRT
<213>  Homo sapiens

<400>  7

Glu Pro His Ser Leu Arg Tyr Asn Leu Thr Val Leu Ser Trp Asp Gly 
1               5                   10                  15      


Ser Val Gln Ser Gly Phe Leu Thr Glu Val His Leu Asp Gly Gln Pro 
            20                  25                  30          


Phe Leu Arg Cys Asp Arg Gln Lys Cys Arg Ala Lys Pro Gln Gly Gln 
        35                  40                  45              


Trp Ala Glu Asp Val Leu Gly Asn Lys Thr Trp Asp Arg Glu Thr Arg 
    50                  55                  60                  


Asp Leu Thr Gly Asn Gly Lys Asp Leu Arg Met Thr Leu Ala His Ile 
65                  70                  75                  80  


Lys Asp Gln Lys Glu Gly Leu His Ser Leu Gln Glu Ile Arg Val Cys 
                85                  90                  95      


Glu Ile His Glu Asp Asn Ser Thr Arg Ser Ser Gln His Phe Tyr Tyr 
            100                 105                 110         


Asp Gly Glu Leu Phe Leu Ser Gln Asn Leu Glu Thr Lys Glu Trp Thr 
        115                 120                 125             


Met Pro Gln Ser Ser Arg Ala Gln Thr Leu Ala Met Asn Val Arg Asn 
    130                 135                 140                 


Phe Leu Lys Glu Asp Ala Met Lys Thr Lys Thr His Tyr His Ala Met 
145                 150                 155                 160 


His Ala Asp Cys Leu Gln Glu Leu Arg Arg Tyr Leu Lys Ser Gly Val 
                165                 170                 175     


Val Leu Arg Arg Thr Val Pro Pro Met Val Asn Val Thr Arg Ser Glu 
            180                 185                 190         


Ala Ser Glu Gly Asn Ile Thr Val Thr Cys Arg Ala Ser Gly Phe Tyr 
        195                 200                 205             


Pro Trp Asn Ile Thr Leu Ser Trp Arg Gln Asp Gly Val Ser Leu Ser 
    210                 215                 220                 


His Asp Thr Gln Gln Trp Gly Asp Val Leu Pro Asp Gly Asn Gly Thr 
225                 230                 235                 240 


Tyr Gln Thr Trp Val Ala Thr Arg Ile Cys Gln Gly Glu Glu Gln Arg 
                245                 250                 255     


Phe Thr Cys Tyr Met Glu His Ser Gly Asn His Ser Thr His Pro Val 
            260                 265                 270         


Pro Ser 
        


<210>  8
<211>  274
<212>  PRT
<213>  Homo sapiens

<400>  8

Glu Pro His Ser Leu Arg Tyr Asn Leu Thr Val Leu Ser Trp Asp Gly 
1               5                   10                  15      


Ser Val Gln Ser Gly Phe Leu Thr Glu Val His Leu Asp Gly Gln Pro 
            20                  25                  30          


Phe Leu Arg Cys Asp Arg Gln Lys Cys Arg Ala Lys Pro Gln Gly Gln 
        35                  40                  45              


Trp Ala Glu Asp Val Leu Gly Asn Lys Thr Trp Asp Arg Glu Thr Arg 
    50                  55                  60                  


Asp Leu Thr Gly Asn Gly Lys Asp Leu Arg Met Thr Leu Ala His Ile 
65                  70                  75                  80  


Lys Asp Gln Lys Glu Gly Leu His Ser Leu Gln Glu Ile Arg Val Cys 
                85                  90                  95      


Glu Ile His Glu Asp Asn Ser Thr Arg Ser Ser Gln His Phe Tyr Tyr 
            100                 105                 110         


Asp Gly Glu Leu Phe Leu Ser Gln Asn Leu Glu Thr Glu Glu Trp Thr 
        115                 120                 125             


Met Pro Gln Ser Ser Arg Ala Gln Thr Leu Ala Met Asn Val Arg Asn 
    130                 135                 140                 


Phe Leu Lys Glu Asp Ala Met Lys Thr Lys Thr Leu Tyr His Ala Met 
145                 150                 155                 160 


His Ala Asp Cys Leu Gln Glu Leu Arg Arg Tyr Leu Lys Ser Gly Val 
                165                 170                 175     


Val Leu Arg Arg Thr Val Pro Pro Met Val Asn Val Thr Arg Ser Glu 
            180                 185                 190         


Ala Ser Glu Gly Asn Ile Thr Val Thr Cys Arg Ala Ser Gly Phe Tyr 
        195                 200                 205             


Pro Trp Asn Ile Thr Leu Ser Trp Arg Gln Asp Gly Val Ser Leu Ser 
    210                 215                 220                 


His Asp Thr Gln Gln Trp Gly Asp Val Leu Pro Asp Gly Asn Gly Thr 
225                 230                 235                 240 


Tyr Gln Thr Trp Val Ala Thr Arg Ile Cys Gln Gly Glu Glu Gln Arg 
                245                 250                 255     


Phe Thr Cys Tyr Met Glu His Ser Gly Asn His Ser Thr His Pro Val 
            260                 265                 270         


Pro Ser 
        


<210>  9
<211>  274
<212>  PRT
<213>  Homo sapiens

<400>  9

Glu Pro His Ser Leu Arg Tyr Asn Leu Thr Val Leu Ser Trp Asp Gly 
1               5                   10                  15      


Ser Val Gln Ser Gly Phe Leu Ala Glu Val His Leu Asp Gly Gln Pro 
            20                  25                  30          


Phe Leu Arg Cys Asp Arg Gln Lys Cys Arg Ala Lys Pro Gln Gly Gln 
        35                  40                  45              


Trp Ala Glu Asp Val Leu Gly Asn Lys Thr Trp Asp Arg Glu Thr Arg 
    50                  55                  60                  


Asp Leu Thr Gly Asn Gly Lys Asp Leu Arg Met Thr Leu Ala His Ile 
65                  70                  75                  80  


Lys Asp Gln Lys Glu Gly Leu His Ser Leu Gln Glu Ile Arg Val Cys 
                85                  90                  95      


Glu Ile His Glu Asp Asn Ser Thr Arg Ser Ser Gln His Phe Tyr Tyr 
            100                 105                 110         


Asp Gly Glu Leu Phe Leu Ser Gln Asn Leu Glu Thr Glu Glu Trp Thr 
        115                 120                 125             


Met Pro Gln Ser Ser Arg Ala Gln Thr Leu Ala Met Asn Ile Arg Asn 
    130                 135                 140                 


Phe Leu Lys Glu Asp Ala Met Lys Thr Lys Thr His Tyr His Ala Met 
145                 150                 155                 160 


His Ala Asp Cys Leu Gln Glu Leu Arg Arg Tyr Leu Lys Ser Gly Val 
                165                 170                 175     


Val Leu Arg Arg Thr Val Pro Pro Met Val Asn Val Thr Arg Ser Glu 
            180                 185                 190         


Ala Ser Glu Gly Asn Ile Thr Val Thr Cys Arg Ala Ser Gly Phe Tyr 
        195                 200                 205             


Pro Trp Asn Ile Thr Leu Ser Trp Arg Gln Asp Gly Val Ser Leu Ser 
    210                 215                 220                 


His Asp Thr Gln Gln Trp Gly Asp Val Leu Pro Asp Gly Asn Gly Thr 
225                 230                 235                 240 


Tyr Gln Thr Trp Val Ala Thr Arg Ile Cys Gln Gly Glu Glu Gln Arg 
                245                 250                 255     


Phe Thr Cys Tyr Met Glu His Ser Gly Asn His Ser Thr His Pro Val 
            260                 265                 270         


Pro Ser 
        


<210>  10
<211>  274
<212>  PRT
<213>  Homo sapiens

<400>  10

Glu Pro His Ser Leu Pro Tyr Asn Leu Thr Val Leu Ser Trp Asp Gly 
1               5                   10                  15      


Ser Val Gln Ser Gly Phe Leu Ala Glu Val His Leu Asp Gly Gln Pro 
            20                  25                  30          


Phe Leu Arg Tyr Asp Arg Gln Lys Cys Arg Ala Lys Pro Gln Gly Gln 
        35                  40                  45              


Trp Ala Glu Asp Val Leu Gly Asn Lys Thr Trp Asp Arg Glu Thr Arg 
    50                  55                  60                  


Asp Leu Thr Gly Asn Gly Lys Asp Leu Arg Met Thr Leu Ala His Ile 
65                  70                  75                  80  


Lys Asp Gln Lys Glu Gly Leu His Ser Leu Gln Glu Ile Arg Val Cys 
                85                  90                  95      


Glu Ile His Glu Asp Asn Ser Thr Arg Ser Ser Gln His Phe Tyr Tyr 
            100                 105                 110         


Asp Gly Glu Leu Phe Leu Ser Gln Asn Leu Glu Thr Glu Glu Trp Thr 
        115                 120                 125             


Met Pro Gln Ser Ser Arg Ala Gln Thr Leu Ala Met Asn Val Arg Asn 
    130                 135                 140                 


Phe Leu Lys Glu Asp Ala Met Lys Thr Lys Thr His Tyr His Ala Met 
145                 150                 155                 160 


His Ala Asp Cys Leu Gln Glu Leu Arg Arg Tyr Leu Lys Ser Gly Val 
                165                 170                 175     


Val Leu Arg Arg Thr Val Pro Pro Met Val Asn Val Thr Arg Ser Glu 
            180                 185                 190         


Ala Ser Glu Gly Asn Ile Thr Val Thr Cys Arg Ala Ser Gly Phe Tyr 
        195                 200                 205             


Pro Trp Asn Ile Thr Leu Ser Trp Arg Gln Asp Gly Val Ser Leu Ser 
    210                 215                 220                 


His Asp Thr Gln Gln Trp Gly Asp Val Leu Pro Asp Gly Asn Gly Thr 
225                 230                 235                 240 


Tyr Gln Thr Trp Val Ala Thr Arg Ile Cys Gln Gly Glu Glu Gln Arg 
                245                 250                 255     


Phe Thr Cys Tyr Met Glu His Ser Gly Asn His Ser Thr His Pro Val 
            260                 265                 270         


Pro Ser 
        


<210>  11
<211>  274
<212>  PRT
<213>  Homo sapiens

<400>  11

Glu Pro His Ser Leu Arg Tyr Asn Leu Thr Val Leu Ser Trp Asp Gly 
1               5                   10                  15      


Ser Val Gln Ser Gly Phe Leu Ala Glu Val His Leu Asp Gly Gln Pro 
            20                  25                  30          


Phe Leu Arg Tyr Asp Arg Gln Lys Cys Arg Ala Lys Pro Gln Gly Gln 
        35                  40                  45              


Trp Ala Glu Asp Val Leu Gly Asn Lys Thr Trp Asp Arg Glu Thr Arg 
    50                  55                  60                  


Asp Leu Thr Gly Asn Gly Lys Asp Leu Arg Met Thr Leu Ala His Ile 
65                  70                  75                  80  


Lys Asp Gln Lys Glu Gly Leu His Ser Leu Gln Glu Ile Arg Val Cys 
                85                  90                  95      


Glu Ile His Glu Asp Asn Ser Thr Arg Ser Ser Gln His Phe Tyr Tyr 
            100                 105                 110         


Asp Gly Glu Leu Phe Leu Ser Gln Asn Leu Glu Thr Glu Glu Trp Thr 
        115                 120                 125             


Val Pro Gln Ser Ser Arg Ala Gln Thr Leu Ala Met Asn Val Arg Asn 
    130                 135                 140                 


Phe Leu Lys Glu Asp Ala Met Lys Thr Lys Thr His Tyr His Ala Met 
145                 150                 155                 160 


His Ala Asp Cys Leu Gln Glu Leu Arg Arg Tyr Leu Glu Ser Gly Val 
                165                 170                 175     


Val Leu Arg Arg Thr Val Pro Pro Met Val Asn Val Thr Arg Ser Glu 
            180                 185                 190         


Ala Ser Glu Gly Asn Ile Thr Val Thr Cys Arg Ala Ser Ser Phe Tyr 
        195                 200                 205             


Pro Arg Asn Ile Thr Leu Thr Trp Arg Gln Asp Gly Val Ser Leu Ser 
    210                 215                 220                 


His Asp Thr Gln Gln Trp Gly Asp Val Leu Pro Asp Gly Asn Gly Thr 
225                 230                 235                 240 


Tyr Gln Thr Trp Val Ala Thr Arg Ile Cys Gln Gly Glu Glu Gln Arg 
                245                 250                 255     


Phe Thr Cys Tyr Met Glu His Ser Gly Asn His Ser Thr His Pro Val 
            260                 265                 270         


Pro Ser 
        


<210>  12
<211>  274
<212>  PRT
<213>  Homo sapiens

<400>  12

Glu Pro His Ser Leu Arg Tyr Asn Leu Thr Val Leu Ser Trp Asp Gly 
1               5                   10                  15      


Ser Val Gln Ser Gly Phe Leu Thr Glu Val His Leu Asp Gly Gln Pro 
            20                  25                  30          


Phe Leu Arg Cys Asp Arg Gln Lys Cys Arg Ala Lys Pro Gln Gly Gln 
        35                  40                  45              


Trp Ala Glu Asp Val Leu Gly Asn Lys Thr Trp Asp Arg Glu Thr Arg 
    50                  55                  60                  


Asp Leu Thr Gly Asn Gly Lys Asp Leu Arg Met Thr Leu Ala His Ile 
65                  70                  75                  80  


Lys Asp Gln Lys Glu Gly Leu His Ser Leu Gln Glu Ile Arg Val Cys 
                85                  90                  95      


Glu Ile His Glu Asp Asn Ser Thr Arg Ser Ser Gln His Phe Tyr Tyr 
            100                 105                 110         


Asp Gly Glu Leu Phe Leu Ser Gln Asn Leu Glu Thr Glu Glu Trp Thr 
        115                 120                 125             


Met Pro Gln Ser Ser Arg Ala Gln Thr Leu Ala Met Asn Val Arg Asn 
    130                 135                 140                 


Phe Leu Lys Glu Asp Ala Met Lys Thr Lys Thr His Tyr His Ala Met 
145                 150                 155                 160 


His Ala Asp Cys Leu Gln Glu Leu Arg Arg Tyr Leu Lys Ser Gly Val 
                165                 170                 175     


Val Leu Arg Arg Thr Val Pro Pro Met Val Asn Val Thr Arg Ser Glu 
            180                 185                 190         


Ala Ser Glu Gly Asn Ile Thr Val Thr Cys Arg Ala Ser Gly Phe Tyr 
        195                 200                 205             


Pro Trp Asn Ile Thr Leu Ser Trp Arg Gln Asp Gly Val Ser Leu Ser 
    210                 215                 220                 


His Asp Thr Gln Gln Trp Gly Asp Val Leu Pro Asp Gly Asn Gly Thr 
225                 230                 235                 240 


Tyr Gln Thr Trp Val Ala Thr Arg Ile Cys Gln Gly Glu Glu Gln Arg 
                245                 250                 255     


Phe Thr Cys Tyr Met Glu His Ser Gly Asn His Ser Thr His Pro Val 
            260                 265                 270         


Pro Ser 
        


<210>  13
<211>  274
<212>  PRT
<213>  Homo sapiens

<400>  13

Glu Pro His Ser Leu Arg Tyr Asn Leu Thr Val Leu Ser Trp Asp Gly 
1               5                   10                  15      


Ser Val Gln Ser Gly Phe Leu Ala Glu Val His Leu Asp Gly Gln Pro 
            20                  25                  30          


Phe Leu Arg Cys Asp Arg Gln Lys Cys Arg Ala Lys Pro Gln Gly Gln 
        35                  40                  45              


Trp Ala Glu Asp Val Leu Gly Asn Lys Thr Trp Asp Arg Glu Thr Arg 
    50                  55                  60                  


Asp Leu Thr Gly Asn Gly Lys Asp Leu Arg Met Thr Leu Ala His Ile 
65                  70                  75                  80  


Lys Asp Gln Lys Glu Gly Leu His Ser Leu Gln Glu Ile Arg Val Cys 
                85                  90                  95      


Glu Ile His Glu Asp Asn Ser Thr Arg Ser Ser Gln His Phe Tyr Tyr 
            100                 105                 110         


Asp Gly Glu Leu Phe Leu Ser Gln Asn Leu Glu Thr Glu Glu Trp Thr 
        115                 120                 125             


Met Pro Gln Ser Ser Arg Ala Gln Thr Leu Ala Met Asn Val Arg Asn 
    130                 135                 140                 


Phe Leu Lys Glu Asp Ala Met Lys Thr Lys Thr His Tyr His Ala Met 
145                 150                 155                 160 


His Ala Asp Cys Leu Gln Glu Leu Arg Arg Tyr Leu Lys Ser Gly Val 
                165                 170                 175     


Val Leu Arg Arg Thr Val Pro Pro Met Val Asn Val Thr Arg Ser Glu 
            180                 185                 190         


Ala Ser Glu Gly Asn Ile Thr Val Thr Cys Arg Ala Ser Gly Phe Tyr 
        195                 200                 205             


Pro Trp Asn Ile Thr Leu Ser Trp Arg Gln Asp Gly Val Ser Leu Ser 
    210                 215                 220                 


His Asp Thr Gln Gln Trp Gly Asp Val Leu Pro Asp Gly Asn Gly Thr 
225                 230                 235                 240 


Tyr Gln Thr Trp Val Ala Thr Arg Ile Cys Gln Gly Glu Glu Gln Arg 
                245                 250                 255     


Phe Thr Cys Tyr Met Glu His Ser Gly Asn His Ser Thr His Pro Val 
            260                 265                 270         


Pro Ser 
        


<210>  14
<211>  276
<212>  PRT
<213>  Homo sapiens

<400>  14

Glu Pro His Ser Leu Arg Tyr Asn Leu Thr Val Leu Ser Trp Asp Gly 
1               5                   10                  15      


Ser Val Gln Ser Gly Phe Leu Thr Glu Val His Leu Asp Gly Gln Pro 
            20                  25                  30          


Phe Leu Arg Cys Asp Arg Gln Lys Cys Arg Ala Lys Pro Gln Gly Gln 
        35                  40                  45              


Trp Ala Glu Asp Val Leu Gly Asn Lys Thr Trp Asp Arg Glu Thr Arg 
    50                  55                  60                  


Asp Leu Thr Gly Asn Gly Lys Asp Leu Arg Met Thr Leu Ala His Ile 
65                  70                  75                  80  


Lys Asp Gln Lys Glu Gly Leu His Ser Leu Gln Glu Ile Arg Val Cys 
                85                  90                  95      


Glu Ile His Glu Asp Asn Ser Thr Arg Ser Ser Gln His Phe Tyr Tyr 
            100                 105                 110         


Asp Gly Glu Leu Phe Leu Ser Gln Asn Leu Glu Thr Lys Glu Trp Thr 
        115                 120                 125             


Met Pro Gln Ser Ser Arg Ala Gln Thr Leu Ala Met Asn Val Arg Asn 
    130                 135                 140                 


Phe Leu Lys Glu Asp Ala Met Lys Thr Lys Thr His Tyr His Ala Met 
145                 150                 155                 160 


His Ala Asp Cys Leu Gln Glu Leu Arg Arg Tyr Leu Lys Ser Gly Val 
                165                 170                 175     


Val Leu Arg Arg Thr Val Pro Pro Met Val Asn Val Thr Arg Ser Glu 
            180                 185                 190         


Ala Ser Glu Gly Asn Ile Thr Val Thr Cys Arg Ala Ser Gly Phe Tyr 
        195                 200                 205             


Pro Trp Asn Ile Thr Leu Ser Trp Arg Gln Asp Gly Val Ser Leu Ser 
    210                 215                 220                 


His Asp Thr Gln Gln Trp Gly Asp Val Leu Pro Asp Gly Asn Gly Thr 
225                 230                 235                 240 


Tyr Gln Thr Trp Val Ala Thr Arg Ile Cys Gln Gly Glu Glu Gln Arg 
                245                 250                 255     


Phe Thr Cys Tyr Met Glu His Ser Gly Asn His Ser Thr His Pro Val 
            260                 265                 270         


Pro Ser Gly Lys 
        275     


<210>  15
<211>  274
<212>  PRT
<213>  Homo sapiens

<400>  15

Glu Pro His Ser Leu Arg Tyr Asn Leu Met Val Leu Ser Gln Asp Glu 
1               5                   10                  15      


Ser Val Gln Ser Gly Phe Leu Ala Glu Gly His Leu Asp Gly Gln Pro 
            20                  25                  30          


Phe Leu Arg Tyr Asp Arg Gln Lys Arg Arg Ala Lys Pro Gln Gly Gln 
        35                  40                  45              


Trp Ala Glu Asp Val Leu Gly Ala Lys Thr Trp Asp Thr Glu Thr Glu 
    50                  55                  60                  


Asp Leu Thr Glu Asn Gly Gln Asp Leu Arg Arg Thr Leu Thr His Ile 
65                  70                  75                  80  


Lys Asp Gln Lys Gly Gly Leu His Ser Leu Gln Glu Ile Arg Val Cys 
                85                  90                  95      


Glu Ile His Glu Asp Ser Ser Thr Arg Gly Ser Arg His Phe Tyr Tyr 
            100                 105                 110         


Asp Gly Glu Leu Phe Leu Ser Gln Asn Leu Glu Thr Gln Glu Ser Thr 
        115                 120                 125             


Val Pro Gln Ser Ser Arg Ala Gln Thr Leu Ala Met Asn Val Thr Asn 
    130                 135                 140                 


Phe Trp Lys Glu Asp Ala Met Lys Thr Lys Thr His Tyr Arg Ala Met 
145                 150                 155                 160 


Gln Ala Asp Cys Leu Gln Lys Leu Gln Arg Tyr Leu Lys Ser Gly Val 
                165                 170                 175     


Ala Ile Arg Arg Thr Val Pro Pro Met Val Asn Val Thr Cys Ser Glu 
            180                 185                 190         


Val Ser Glu Gly Asn Ile Thr Val Thr Cys Arg Ala Ser Ser Phe Tyr 
        195                 200                 205             


Pro Arg Asn Ile Thr Leu Thr Trp Arg Gln Asp Gly Val Ser Leu Ser 
    210                 215                 220                 


His Asn Thr Gln Gln Trp Gly Asp Val Leu Pro Asp Gly Asn Gly Thr 
225                 230                 235                 240 


Tyr Gln Thr Trp Val Ala Thr Arg Ile Arg Gln Gly Glu Glu Gln Arg 
                245                 250                 255     


Phe Thr Cys Tyr Met Glu His Ser Gly Asn His Gly Thr His Pro Val 
            260                 265                 270         


Pro Ser 
        


<210>  16
<211>  275
<212>  PRT
<213>  Homo sapiens

<400>  16

Pro His Ser Leu Arg Tyr Asn Leu Met Val Leu Ser Gln Asp Gly Ser 
1               5                   10                  15      


Val Gln Ser Gly Phe Leu Ala Glu Gly His Leu Asp Gly Gln Pro Phe 
            20                  25                  30          


Leu Arg Tyr Asp Arg Gln Lys Arg Arg Ala Lys Pro Gln Gly Gln Trp 
        35                  40                  45              


Ala Glu Asp Val Leu Gly Ala Lys Thr Trp Asp Thr Glu Thr Glu Asp 
    50                  55                  60                  


Leu Thr Glu Asn Gly Gln Asp Leu Arg Arg Thr Leu Thr His Ile Lys 
65                  70                  75                  80  


Asp Gln Lys Gly Gly Leu His Ser Leu Gln Glu Ile Arg Val Cys Glu 
                85                  90                  95      


Ile His Glu Asp Ser Ser Thr Arg Gly Ser Arg His Phe Tyr Tyr Asp 
            100                 105                 110         


Gly Glu Leu Phe Leu Ser Gln Asn Leu Glu Thr Gln Glu Ser Thr Val 
        115                 120                 125             


Pro Gln Ser Ser Arg Ala Gln Thr Leu Ala Met Asn Val Thr Asn Phe 
    130                 135                 140                 


Trp Lys Glu Asp Ala Met Lys Thr Lys Thr His Tyr Arg Ala Met Gln 
145                 150                 155                 160 


Ala Asp Cys Leu Gln Lys Leu Gln Leu Pro Pro Met Val Asn Val Ile 
                165                 170                 175     


Cys Ser Glu Val Ser Glu Gly Asn Ile Thr Val Thr Cys Arg Ala Ser 
            180                 185                 190         


Ser Phe Tyr Pro Arg Asn Ile Thr Leu Thr Trp Arg Gln Asp Gly Val 
        195                 200                 205             


Ser Leu Ser His Asn Thr Gln Gln Trp Gly Asp Val Leu Pro Asp Gly 
    210                 215                 220                 


Asn Gly Thr Tyr Gln Thr Trp Val Ala Thr Arg Ile Arg Gln Gly Glu 
225                 230                 235                 240 


Glu Gln Arg Phe Thr Cys Tyr Met Glu His Ser Gly Asn His Gly Thr 
                245                 250                 255     


His Pro Val Pro Ser Gly Lys Ala Leu Val Leu Gln Ser Gln Arg Thr 
            260                 265                 270         


Asp Phe Pro 
        275 


<210>  17
<211>  273
<212>  PRT
<213>  Homo sapiens

<400>  17

Pro His Ser Leu Arg Tyr Asn Leu Met Val Leu Ser Gln Asp Gly Ser 
1               5                   10                  15      


Val Gln Ser Gly Phe Leu Ala Glu Gly His Leu Asp Gly Gln Pro Phe 
            20                  25                  30          


Leu Arg Tyr Asp Arg Gln Lys Arg Arg Ala Lys Pro Gln Gly Gln Trp 
        35                  40                  45              


Ala Glu Asp Val Leu Gly Ala Glu Thr Trp Asp Thr Glu Thr Glu Asp 
    50                  55                  60                  


Leu Thr Glu Asn Gly Gln Asp Leu Arg Arg Thr Leu Thr His Ile Lys 
65                  70                  75                  80  


Asp Gln Lys Gly Gly Leu His Ser Leu Gln Glu Ile Arg Val Cys Glu 
                85                  90                  95      


Met His Glu Asp Ser Ser Thr Arg Gly Ser Arg His Phe Tyr Tyr Asn 
            100                 105                 110         


Gly Glu Leu Phe Leu Ser Gln Asn Leu Glu Thr Gln Glu Ser Thr Val 
        115                 120                 125             


Pro Gln Ser Ser Arg Ala Gln Thr Leu Ala Met Asn Val Thr Asn Phe 
    130                 135                 140                 


Trp Lys Glu Asp Ala Met Lys Thr Lys Thr His Tyr Arg Ala Met Gln 
145                 150                 155                 160 


Ala Asp Cys Leu Gln Lys Leu Gln Arg Tyr Leu Lys Ser Gly Val Ala 
                165                 170                 175     


Ile Arg Arg Thr Val Pro Pro Met Val Asn Val Thr Cys Ser Glu Val 
            180                 185                 190         


Ser Glu Gly Asn Ile Thr Val Thr Cys Arg Ala Ser Ser Phe Tyr Pro 
        195                 200                 205             


Arg Asn Ile Thr Leu Thr Trp Arg Gln Asp Gly Val Ser Leu Ser His 
    210                 215                 220                 


Asn Thr Gln Gln Trp Gly Asp Val Leu Pro Asp Gly Asn Gly Thr Tyr 
225                 230                 235                 240 


Gln Thr Trp Val Ala Thr Arg Ile Arg Gln Gly Glu Glu Gln Arg Phe 
                245                 250                 255     


Thr Cys Tyr Met Glu His Ser Gly Asn His Gly Thr His Pro Val Pro 
            260                 265                 270         


Ser 
    


<210>  18
<211>  273
<212>  PRT
<213>  Homo sapiens

<400>  18

Pro His Ser Leu Arg Tyr Asn Leu Met Val Leu Ser Gln Asp Gly Ser 
1               5                   10                  15      


Val Gln Ser Gly Phe Leu Ala Glu Gly His Leu Asp Gly Gln Pro Phe 
            20                  25                  30          


Leu Arg Tyr Asp Arg Gln Lys Arg Arg Ala Lys Pro Gln Gly Gln Trp 
        35                  40                  45              


Ala Glu Asp Val Leu Gly Ala Lys Thr Trp Asp Thr Glu Thr Glu Asp 
    50                  55                  60                  


Leu Thr Glu Asn Gly Gln Asp Leu Arg Arg Thr Leu Thr His Ile Lys 
65                  70                  75                  80  


Asp Gln Lys Gly Gly Leu His Ser Leu Gln Glu Ile Arg Val Cys Glu 
                85                  90                  95      


Ile His Glu Asp Ser Ser Thr Arg Gly Ser Arg His Phe Tyr Tyr Asp 
            100                 105                 110         


Gly Glu Leu Phe Leu Ser Gln Asn Leu Glu Thr Gln Glu Ser Thr Val 
        115                 120                 125             


Pro Gln Ser Ser Arg Ala Gln Thr Leu Ala Met Asn Val Thr Asn Phe 
    130                 135                 140                 


Trp Lys Glu Asp Ala Met Lys Thr Lys Thr His Tyr Arg Ala Met Gln 
145                 150                 155                 160 


Ala Asp Cys Leu Gln Lys Leu Gln Arg Tyr Leu Lys Ser Gly Val Ala 
                165                 170                 175     


Ile Arg Arg Thr Val Pro Pro Met Val Asn Val Ile Cys Ser Glu Val 
            180                 185                 190         


Ser Glu Gly Asn Ile Thr Val Thr Cys Arg Ala Ser Ser Phe Tyr Pro 
        195                 200                 205             


Arg Asn Ile Thr Leu Thr Trp Arg Gln Asp Gly Val Ser Leu Ser His 
    210                 215                 220                 


Asn Thr Gln Gln Trp Gly Asp Val Leu Pro Asp Gly Asn Gly Thr Tyr 
225                 230                 235                 240 


Gln Thr Trp Val Ala Thr Arg Ile Arg Gln Gly Glu Glu Gln Arg Phe 
                245                 250                 255     


Thr Cys Tyr Met Glu His Ser Gly Asn His Gly Thr His Pro Val Pro 
            260                 265                 270         


Ser 
    


<210>  19
<211>  273
<212>  PRT
<213>  Homo sapiens

<400>  19

Pro His Ser Leu Arg Tyr Asn Leu Met Val Leu Ser Gln Asp Gly Ser 
1               5                   10                  15      


Val Gln Ser Gly Phe Leu Ala Glu Gly His Leu Asp Gly Gln Pro Phe 
            20                  25                  30          


Leu Arg Tyr Asp Arg Gln Lys Arg Arg Ala Lys Pro Gln Gly Gln Trp 
        35                  40                  45              


Ala Glu Asn Val Leu Gly Ala Lys Thr Trp Asp Thr Glu Thr Glu Asp 
    50                  55                  60                  


Leu Thr Glu Asn Gly Gln Asp Leu Arg Arg Thr Leu Thr His Ile Lys 
65                  70                  75                  80  


Asp Gln Lys Gly Gly Leu His Ser Leu Gln Glu Ile Arg Val Cys Glu 
                85                  90                  95      


Ile His Glu Asp Ser Ser Thr Arg Gly Ser Arg His Phe Tyr Tyr Asp 
            100                 105                 110         


Gly Glu Leu Phe Leu Ser Gln Asn Leu Glu Thr Gln Glu Ser Thr Val 
        115                 120                 125             


Pro Gln Ser Ser Arg Ala Gln Thr Leu Ala Met Asn Val Thr Asn Phe 
    130                 135                 140                 


Trp Lys Glu Asp Ala Met Lys Thr Lys Thr His Tyr Arg Ala Met Gln 
145                 150                 155                 160 


Ala Asp Cys Leu Gln Lys Leu Gln Arg Tyr Leu Lys Ser Gly Val Ala 
                165                 170                 175     


Ile Arg Arg Thr Val Pro Pro Met Val Asn Val Thr Cys Ser Glu Val 
            180                 185                 190         


Ser Glu Gly Asn Ile Thr Val Thr Cys Arg Ala Ser Ser Phe Tyr Pro 
        195                 200                 205             


Arg Asn Ile Thr Leu Thr Trp Arg Gln Asp Gly Val Ser Leu Ser His 
    210                 215                 220                 


Asn Thr Gln Gln Trp Gly Asp Val Leu Pro Asp Gly Asn Gly Thr Tyr 
225                 230                 235                 240 


Gln Thr Trp Val Ala Thr Arg Ile Arg Gln Gly Glu Glu Gln Arg Phe 
                245                 250                 255     


Thr Cys Tyr Met Glu His Ser Gly Asn His Gly Thr His Pro Val Pro 
            260                 265                 270         


Ser 
    


<210>  20
<211>  273
<212>  PRT
<213>  Homo sapiens

<400>  20

Pro His Ser Leu Arg Tyr Asn Leu Met Val Leu Ser Gln Asp Gly Ser 
1               5                   10                  15      


Val Gln Ser Gly Phe Leu Ala Glu Gly His Leu Asp Gly Gln Pro Phe 
            20                  25                  30          


Leu Arg Tyr Asp Arg Gln Lys Arg Arg Ala Lys Pro Gln Gly Gln Trp 
        35                  40                  45              


Ala Glu Asp Val Leu Gly Ala Glu Thr Trp Asp Thr Glu Thr Glu Asp 
    50                  55                  60                  


Leu Thr Glu Asn Gly Gln Asp Leu Arg Arg Thr Leu Thr His Ile Lys 
65                  70                  75                  80  


Asp Gln Lys Gly Gly Leu His Ser Leu Gln Glu Ile Arg Val Cys Glu 
                85                  90                  95      


Ile His Glu Asp Ser Ser Thr Arg Gly Ser Arg His Phe Tyr Tyr Asn 
            100                 105                 110         


Gly Glu Leu Phe Leu Ser Gln Asn Leu Glu Thr Gln Glu Ser Thr Val 
        115                 120                 125             


Pro Gln Ser Ser Arg Ala Gln Thr Leu Ala Met Asn Val Thr Asn Phe 
    130                 135                 140                 


Trp Lys Glu Asp Ala Met Lys Thr Lys Thr His Tyr Arg Ala Met Gln 
145                 150                 155                 160 


Ala Asp Cys Leu Gln Lys Leu Gln Arg Tyr Leu Lys Ser Gly Val Ala 
                165                 170                 175     


Ile Arg Arg Thr Val Pro Pro Met Val Asn Val Thr Cys Ser Glu Val 
            180                 185                 190         


Ser Glu Gly Asn Ile Thr Val Thr Cys Arg Ala Ser Ser Phe Tyr Pro 
        195                 200                 205             


Arg Asn Ile Thr Leu Thr Trp Arg Gln Asp Gly Val Ser Leu Ser His 
    210                 215                 220                 


Asn Thr Gln Gln Trp Gly Asp Val Leu Pro Asp Gly Asn Gly Thr Tyr 
225                 230                 235                 240 


Gln Thr Trp Val Ala Thr Arg Ile Arg Gln Gly Glu Glu Gln Lys Phe 
                245                 250                 255     


Thr Cys Tyr Met Glu His Ser Gly Asn His Gly Thr His Pro Val Pro 
            260                 265                 270         


Ser 
    


<210>  21
<211>  273
<212>  PRT
<213>  Homo sapiens

<400>  21

Pro His Ser Leu Arg Tyr Asn Leu Met Val Leu Ser Gln Asp Gly Ser 
1               5                   10                  15      


Val Gln Ser Gly Phe Leu Ala Glu Gly His Leu Asp Gly Gln Pro Phe 
            20                  25                  30          


Leu Arg Tyr Asp Arg Gln Lys Arg Arg Ala Lys Pro Gln Gly Gln Trp 
        35                  40                  45              


Ala Glu Asp Val Leu Gly Ala Glu Thr Trp Asp Thr Glu Thr Glu Asp 
    50                  55                  60                  


Leu Thr Glu Asn Gly Gln Asp Leu Arg Arg Thr Leu Thr His Ile Lys 
65                  70                  75                  80  


Asp Gln Lys Gly Gly Leu His Ser Leu Gln Glu Ile Arg Val Cys Glu 
                85                  90                  95      


Ile His Glu Asp Ser Ser Thr Arg Gly Ser Arg His Phe Tyr Tyr Asn 
            100                 105                 110         


Gly Glu Leu Phe Leu Ser Gln Asn Leu Glu Thr Gln Glu Ser Thr Val 
        115                 120                 125             


Pro Gln Ser Ser Arg Ala Gln Thr Leu Ala Met Asn Val Thr Asn Phe 
    130                 135                 140                 


Trp Lys Glu Asp Ala Met Lys Thr Lys Thr His Tyr Arg Ala Met Gln 
145                 150                 155                 160 


Ala Asp Cys Leu Gln Lys Leu Gln Arg Tyr Leu Lys Ser Gly Val Ala 
                165                 170                 175     


Ile Arg Arg Thr Val Pro Pro Met Val Asn Val Thr Cys Ser Glu Val 
            180                 185                 190         


Ser Glu Gly Asn Ile Thr Val Thr Cys Arg Ala Ser Ser Phe Tyr Pro 
        195                 200                 205             


Arg Asn Ile Thr Leu Thr Trp Arg Gln Asp Gly Val Ser Leu Ser His 
    210                 215                 220                 


Asn Thr Gln Gln Trp Gly Asp Val Leu Pro Asp Gly Asn Gly Thr Tyr 
225                 230                 235                 240 


Gln Thr Trp Val Ala Thr Arg Ile Arg Gln Gly Glu Glu Gln Arg Phe 
                245                 250                 255     


Thr Cys Tyr Met Glu His Ser Gly Asn His Gly Thr His Pro Val Pro 
            260                 265                 270         


Ser 
    


<210>  22
<211>  8
<212>  PRT
<213>  Homo sapiens

<400>  22

Gln Gln Trp Gly Asp Val Leu Pro 
1               5               


<210>  23
<211>  4
<212>  PRT
<213>  Homo sapiens

<400>  23

Gly Asp Val Leu 
1               


<210>  24
<211>  140
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  variable light chain of antibody 5C9

<400>  24

Met Lys Leu Pro Val Arg Leu Leu Val Leu Met Phe Trp Ile Pro Ala 
1               5                   10                  15      


Ser Ser Ser Asp Val Leu Met Thr Gln Thr Pro Leu Ser Leu Pro Val 
            20                  25                  30          


Ser Leu Gly Asp Gln Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Ile 
        35                  40                  45              


Val His Ser Asn Gly Asn Thr Tyr Leu Glu Trp Tyr Leu Gln Lys Pro 
    50                  55                  60                  


Gly Gln Ser Pro Lys Leu Leu Ile Tyr Lys Val Ser Asn Arg Phe Ser 
65                  70                  75                  80  


Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr 
                85                  90                  95      


Leu Lys Ile Ser Arg Val Glu Ala Glu Asp Leu Gly Val Tyr Tyr Cys 
            100                 105                 110         


Phe Gln Gly Ser His Val Pro Phe Thr Phe Gly Ser Gly Thr Lys Leu 
        115                 120                 125             


Glu Ile Lys Arg Ala Asp Ala Ala Pro Thr Val Ser 
    130                 135                 140 


<210>  25
<211>  109
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  variable light chain of antibody 5C9

<400>  25

Met Thr Gln Thr Pro Leu Ser Leu Pro Val Ser Leu Gly Asp Gln Ala 
1               5                   10                  15      


Ser Ile Ser Cys Arg Ser Ser Gln Ser Ile Val His Ser Asn Gly Asn 
            20                  25                  30          


Thr Tyr Leu Glu Trp Tyr Leu Gln Lys Pro Gly Gln Ser Pro Lys Leu 
        35                  40                  45              


Leu Ile Tyr Lys Val Ser Asn Arg Phe Ser Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile Ser Arg Val 
65                  70                  75                  80  


Glu Ala Glu Asp Leu Gly Val Tyr Tyr Cys Phe Gln Gly Ser His Val 
                85                  90                  95      


Pro Phe Thr Phe Gly Ser Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 


<210>  26
<211>  393
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  variable light chain of antibody 5C9

<400>  26
atgaagttgc ctgttaggct gttggtgctg atgttctgga ttcctgcttc cagcagtgat       60

gttttgatga cccaaactcc actctccctg cctgtcagtc ttggagatca agcctccatc      120

tcttgcagat ctagtcagag cattgtacat agtaatggaa acacctattt agaatggtac      180

ctgcagaaac caggccagtc tccaaagctc ctgatctaca aagtttccaa ccgattttct      240

ggggtcccag acaggttcag tggcagtgga tcagggacag atttcacact caagatcagc      300

agagtggagg ctgaggatct gggagtttat tactgctttc aaggttcaca tgttccattc      360

acgttcggct cggggacaaa gttggaaata aaa                                   393


<210>  27
<211>  327
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  variable light chain of antibody 5C9

<400>  27
atgacccaaa ctccactctc cctgcctgtc agtcttggag atcaagcctc catctcttgc       60

agatctagtc agagcattgt acatagtaat ggaaacacct atttagaatg gtacctgcag      120

aaaccaggcc agtctccaaa gctcctgatc tacaaagttt ccaaccgatt ttctggggtc      180

ccagacaggt tcagtggcag tggatcaggg acagatttca cactcaagat cagcagagtg      240

gaggctgagg atctgggagt ttattactgc tttcaaggtt cacatgttcc attcacgttc      300

ggctcgggga caaagttgga aataaaa                                          327


<210>  28
<211>  160
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  variable heavy chain of antibody 5C9

<400>  28

Met Glu Trp Ser Gly Val Phe Ile Phe Leu Leu Ser Val Thr Ala Gly 
1               5                   10                  15      


Val His Ser Gln Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Val Arg 
            20                  25                  30          


Pro Gly Thr Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Ala Phe 
        35                  40                  45              


Thr Asn Tyr Leu Ile Glu Trp Val Lys Gln Arg Pro Gly Gln Gly Leu 
    50                  55                  60                  


Glu Trp Ile Gly Leu Ile Tyr Pro Gly Ser Gly Gly Thr Asn Tyr Asn 
65                  70                  75                  80  


Glu Lys Phe Lys Gly Lys Ala Thr Leu Thr Ala Asp Lys Ser Ser Ser 
                85                  90                  95      


Thr Ala Tyr Met Gln Leu Ser Ser Leu Thr Ser Asp Asp Ser Ala Val 
            100                 105                 110         


Tyr Phe Cys Ala Arg Ile Tyr Tyr Gly Asn Arg Asp Tyr Gly Met Asp 
        115                 120                 125             


Tyr Trp Gly Gln Gly Thr Ser Val Thr Val Ser Ser Ala Lys Thr Thr 
    130                 135                 140                 


Pro Pro Ser Val Tyr Pro Leu Ala Pro Gly Cys Gly Asp Thr Thr Gly 
145                 150                 155                 160 


<210>  29
<211>  123
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  variable heavy chain of antibody 5C9

<400>  29

Gln Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Val Arg Pro Gly Thr 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Ala Phe Thr Asn Tyr 
            20                  25                  30          


Leu Ile Glu Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Leu Ile Tyr Pro Gly Ser Gly Gly Thr Asn Tyr Asn Glu Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Ala Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Gln Leu Ser Ser Leu Thr Ser Asp Asp Ser Ala Val Tyr Phe Cys 
                85                  90                  95      


Ala Arg Ile Tyr Tyr Gly Asn Arg Asp Tyr Gly Met Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Ser Val Thr Val Ser Ser Ala Lys 
        115                 120             


<210>  30
<211>  426
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  variable heavy chain of antibody 5C9

<400>  30
atggaatgga gcggagtctt tatctttctc ctgtcagtaa ctgcaggtgt tcactcccag       60

gtccagctgc agcagtctgg agctgagctg gtaaggcctg ggacttcagt gaaggtgtcc      120

tgcaaggctt ctggatacgc cttcactaat tacttgatag agtgggtaaa gcagaggcct      180

ggacagggcc ttgagtggat tggactgatt tatcctggaa gtggtggtac taactacaat      240

gagaaattca agggcaaggc aacactgact gcagacaaat cctccagcac tgcctacatg      300

cagctcagca gcctgacatc tgatgactct gcggtttatt tctgtgcaag aatctactat      360

ggtaacaggg actatggtat ggactactgg ggtcaaggaa cctcagtcac cgtctcctca      420

gccaaa                                                                 426


<210>  31
<211>  369
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  variable heavy chain of antibody 5C9

<400>  31
caggtccagc tgcagcagtc tggagctgag ctggtaaggc ctgggacttc agtgaaggtg       60

tcctgcaagg cttctggata cgccttcact aattacttga tagagtgggt aaagcagagg      120

cctggacagg gccttgagtg gattggactg atttatcctg gaagtggtgg tactaactac      180

aatgagaaat tcaagggcaa ggcaacactg actgcagaca aatcctccag cactgcctac      240

atgcagctca gcagcctgac atctgatgac tctgcggttt atttctgtgc aagaatctac      300

tatggtaaca gggactatgg tatggactac tggggtcaag gaacctcagt caccgtctcc      360

tcagccaaa                                                              369


<210>  32
<211>  87
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  32

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Trp Val 
            20                  25                  30          


Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met Gly Arg Val Thr Ile 
        35                  40                  45              


Thr Ala Asp Thr Ser Thr Ser Thr Ala Tyr Met Glu Leu Ser Ser Leu 
    50                  55                  60                  


Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg Trp Gly Gln Gly 
65                  70                  75                  80  


Thr Leu Val Thr Val Ser Ser 
                85          


<210>  33
<211>  87
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  33

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Gly Ser Val Ser Trp Ile 
            20                  25                  30          


Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile Gly Arg Val Thr Ile 
        35                  40                  45              


Ser Val Asp Thr Ser Lys Asn Gln Phe Ser Leu Lys Leu Ser Ser Val 
    50                  55                  60                  


Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala Arg Trp Gly Gln Gly 
65                  70                  75                  80  


Thr Leu Val Thr Val Ser Ser 
                85          


<210>  34
<211>  87
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  34

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Trp Val 
            20                  25                  30          


Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ser Arg Phe Thr Ile 
        35                  40                  45              


Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu 
    50                  55                  60                  


Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg Trp Gly Gln Gly 
65                  70                  75                  80  


Thr Leu Val Thr Val Ser Ser 
                85          


<210>  35
<211>  87
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  35

Gln Val Gln Leu Val Gln Ser Gly Ser Glu Leu Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Trp Val 
            20                  25                  30          


Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met Gly Arg Phe Val Phe 
        35                  40                  45              


Ser Leu Asp Thr Ser Val Ser Thr Ala Tyr Leu Gln Ile Ser Ser Leu 
    50                  55                  60                  


Lys Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg Trp Gly Gln Gly 
65                  70                  75                  80  


Thr Ser Leu Thr Val Ser Ser 
                85          


<210>  36
<211>  80
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  36

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Trp Tyr Gln Gln Lys Pro Gly Lys Ala 
            20                  25                  30          


Pro Lys Leu Leu Ile Tyr Gly Val Pro Ser Arg Phe Ser Gly Ser Gly 
        35                  40                  45              


Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp 
    50                  55                  60                  


Phe Ala Thr Tyr Tyr Cys Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
65                  70                  75                  80  


<210>  37
<211>  80
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  37

Asp Ile Val Met Thr Gln Ser Pro Leu Ser Leu Pro Val Thr Pro Gly 
1               5                   10                  15      


Glu Pro Ala Ser Ile Ser Cys Trp Tyr Leu Gln Lys Pro Gly Gln Ser 
            20                  25                  30          


Pro Gln Leu Leu Ile Tyr Gly Val Pro Asp Arg Phe Ser Gly Ser Gly 
        35                  40                  45              


Ser Gly Thr Asp Phe Thr Leu Lys Ile Ser Arg Val Glu Ala Glu Asp 
    50                  55                  60                  


Val Gly Val Tyr Tyr Cys Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
65                  70                  75                  80  


<210>  38
<211>  80
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  38

Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Trp Tyr Gln Gln Lys Pro Gly Gln Ala 
            20                  25                  30          


Pro Arg Leu Leu Ile Tyr Gly Ile Pro Asp Arg Phe Ser Gly Ser Gly 
        35                  40                  45              


Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu Pro Glu Asp 
    50                  55                  60                  


Phe Ala Val Tyr Tyr Cys Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
65                  70                  75                  80  


<210>  39
<211>  79
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  39

Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Glu Arg Ala Thr Ile Asn Cys Trp Tyr Gln Gln Lys Pro Gly Gln Pro 
            20                  25                  30          


Pro Lys Leu Leu Ile Tyr Gly Val Pro Asp Arg Phe Ser Gly Ser Gly 
        35                  40                  45              


Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Ala Glu Asp 
    50                  55                  60                  


Val Ala Val Tyr Tyr Cys Phe Gly Gln Gly Thr Lys Val Glu Ile 
65                  70                  75                  


<210>  40
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR L1 of antibody 5C9

<400>  40

Arg Ser Ser Gln Ser Ile Val His Ser Asn Gly Asn Thr Tyr Leu Glu 
1               5                   10                  15      


<210>  41
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR L2 of antibody 5C9

<400>  41

Lys Val Ser Asn Arg Phe Ser 
1               5           


<210>  42
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR L3 of antibody 5C9

<400>  42

Phe Gln Gly Ser His Val Pro Phe Thr 
1               5                   


<210>  43
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR H1 of antibody 5C9

<400>  43

Asn Tyr Leu Ile Glu 
1               5   


<210>  44
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR H2 of antibody 5C9

<400>  44

Leu Ile Tyr Pro Gly Ser Gly Gly Thr Asn Tyr Asn Glu Lys Phe Lys 
1               5                   10                  15      


Gly 
    


<210>  45
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR H3 of antibody 5C9

<400>  45

Ile Tyr Tyr Gly Asn Arg Asp Tyr Gly Met Asp Tyr 
1               5                   10          


<210>  46
<211>  109
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  46

Met Glu Phe Val Pro Pro Met Val Asn Val Thr Arg Ser Glu Ala Ser 
1               5                   10                  15      


Glu Gly Asn Ile Thr Val Thr Cys Arg Ala Ser Gly Phe Tyr Pro Trp 
            20                  25                  30          


Asn Ile Thr Leu Ser Trp Arg Gln Asp Gly Val Ser Leu Ser His Asp 
        35                  40                  45              


Thr Gln Gln Trp Gly Asp Val Leu Pro Asp Gly Asn Gly Thr Tyr Gln 
    50                  55                  60                  


Thr Trp Val Ala Thr Arg Ile Cys Gln Gly Glu Glu Gln Arg Phe Thr 
65                  70                  75                  80  


Cys Tyr Met Glu His Ser Gly Asn His Ser Thr His Pro Val Pro Ser 
                85                  90                  95      


Glu Asn Leu Tyr Phe Gln Gly His His His His His His 
            100                 105                 


<210>  47
<211>  101
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  47

Met Glu Phe Arg Ser Glu Ala Ser Glu Gly Asn Ile Thr Val Thr Cys 
1               5                   10                  15      


Arg Ala Ser Gly Phe Tyr Pro Trp Asn Ile Thr Leu Ser Trp Arg Gln 
            20                  25                  30          


Asp Gly Val Ser Leu Ser His Asp Thr Gln Gln Trp Gly Asp Val Leu 
        35                  40                  45              


Pro Asp Gly Asn Gly Thr Tyr Gln Thr Trp Val Ala Thr Arg Ile Cys 
    50                  55                  60                  


Gln Gly Glu Glu Gln Arg Phe Thr Cys Tyr Met Glu His Ser Gly Asn 
65                  70                  75                  80  


His Ser Thr His Pro Val Pro Ser Glu Asn Leu Tyr Phe Gln Gly His 
                85                  90                  95      


His His His His His 
            100     


<210>  48
<211>  97
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  48

Met Glu Phe Arg Ser Glu Ala Ser Glu Gly Asn Ile Thr Val Thr Cys 
1               5                   10                  15      


Arg Ala Ser Gly Phe Tyr Pro Trp Asn Ile Thr Leu Ser Trp Arg Gln 
            20                  25                  30          


Asp Gly Val Ser Leu Ser His Asp Thr Gln Gln Trp Gly Asp Val Leu 
        35                  40                  45              


Pro Asp Gly Asn Gly Thr Tyr Gln Thr Trp Val Ala Thr Arg Ile Cys 
    50                  55                  60                  


Gln Gly Glu Glu Gln Arg Phe Thr Cys Tyr Met Glu His Ser Gly Asn 
65                  70                  75                  80  


His Ser Thr His Glu Asn Leu Tyr Phe Gln Gly His His His His His 
                85                  90                  95      


His 
    


<210>  49
<211>  83
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  49

Met Glu Phe Arg Ser Glu Ala Ser Glu Gly Asn Ile Thr Val Thr Cys 
1               5                   10                  15      


Arg Ala Ser Gly Phe Tyr Pro Trp Asn Ile Thr Leu Ser Trp Arg Gln 
            20                  25                  30          


Asp Gly Val Ser Leu Ser His Asp Thr Gln Gln Trp Gly Asp Val Leu 
        35                  40                  45              


Pro Asp Gly Asn Gly Thr Tyr Gln Thr Trp Val Ala Thr Arg Ile Cys 
    50                  55                  60                  


Gln Gly Glu Glu Gln Arg Glu Asn Leu Tyr Phe Gln Gly His His His 
65                  70                  75                  80  


His His His 
            


<210>  50
<211>  109
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  50

Met Glu Phe Val Pro Pro Met Val Asn Val Thr Cys Ser Glu Val Ser 
1               5                   10                  15      


Glu Gly Asn Ile Thr Val Thr Cys Arg Ala Ser Ser Phe Tyr Pro Arg 
            20                  25                  30          


Asn Ile Thr Leu Thr Trp Arg Gln Asp Gly Val Ser Leu Ser His Asn 
        35                  40                  45              


Thr Gln Gln Trp Gly Asp Val Leu Pro Asp Gly Asn Gly Thr Tyr Gln 
    50                  55                  60                  


Thr Trp Val Ala Thr Arg Ile Arg Gln Gly Glu Glu Gln Arg Phe Thr 
65                  70                  75                  80  


Cys Tyr Met Glu His Ser Gly Asn His Gly Thr His Pro Val Pro Ser 
                85                  90                  95      


Glu Asn Leu Tyr Phe Gln Gly His His His His His His 
            100                 105                 


<210>  51
<211>  101
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  51

Met Glu Phe Cys Ser Glu Val Ser Glu Gly Asn Ile Thr Val Thr Cys 
1               5                   10                  15      


Arg Ala Ser Ser Phe Tyr Pro Arg Asn Ile Thr Leu Thr Trp Arg Gln 
            20                  25                  30          


Asp Gly Val Ser Leu Ser His Asn Thr Gln Gln Trp Gly Asp Val Leu 
        35                  40                  45              


Pro Asp Gly Asn Gly Thr Tyr Gln Thr Trp Val Ala Thr Arg Ile Arg 
    50                  55                  60                  


Gln Gly Glu Glu Gln Arg Phe Thr Cys Tyr Met Glu His Ser Gly Asn 
65                  70                  75                  80  


His Gly Thr His Pro Val Pro Ser Glu Asn Leu Tyr Phe Gln Gly His 
                85                  90                  95      


His His His His His 
            100     


<210>  52
<211>  97
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  52

Met Glu Phe Cys Ser Glu Val Ser Glu Gly Asn Ile Thr Val Thr Cys 
1               5                   10                  15      


Arg Ala Ser Ser Phe Tyr Pro Arg Asn Ile Thr Leu Thr Trp Arg Gln 
            20                  25                  30          


Asp Gly Val Ser Leu Ser His Asn Thr Gln Gln Trp Gly Asp Val Leu 
        35                  40                  45              


Pro Asp Gly Asn Gly Thr Tyr Gln Thr Trp Val Ala Thr Arg Ile Arg 
    50                  55                  60                  


Gln Gly Glu Glu Gln Arg Phe Thr Cys Tyr Met Glu His Ser Gly Asn 
65                  70                  75                  80  


His Gly Thr His Glu Asn Leu Tyr Phe Gln Gly His His His His His 
                85                  90                  95      


His 
    


<210>  53
<211>  83
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  53

Met Glu Phe Cys Ser Glu Val Ser Glu Gly Asn Ile Thr Val Thr Cys 
1               5                   10                  15      


Arg Ala Ser Ser Phe Tyr Pro Arg Asn Ile Thr Leu Thr Trp Arg Gln 
            20                  25                  30          


Asp Gly Val Ser Leu Ser His Asn Thr Gln Gln Trp Gly Asp Val Leu 
        35                  40                  45              


Pro Asp Gly Asn Gly Thr Tyr Gln Thr Trp Val Ala Thr Arg Ile Arg 
    50                  55                  60                  


Gln Gly Glu Glu Gln Arg Glu Asn Leu Tyr Phe Gln Gly His His His 
65                  70                  75                  80  


His His His 
            


