                         SEQUENCE LISTING

<110>  THE QUEEN'S UNIVERSITY OF BELFAST
       Robson, Tracy
       Yakkundi, Anita
       Bennett, Rachel
       McCarthy, Helen
       Migaud, Marie
       Kissenpfennig, Adrien
       Grieve, David
       Short, Amy
 
<120>  USE OF FKBP-L POLYPEPTIDES AND NUCLEIC ACIDS FOR THE TREATMENT OF OBESITY

<130>  P177550.WO.01

<150>  GB1617726.3
<151>  2016-10-19

<150>  GB1617761.0
<151>  2016-10-20

<160>  43    

<170>  PatentIn version 3.5

<210>  1
<211>  385
<212>  PRT
<213>  Homo sapiens

<400>  1

Met Arg Gly Ser His His His His His His Gly Met Ala Ser Met Thr 
1               5                   10                  15      


Gly Gly Gln Gln Met Gly Arg Asp Leu Tyr Asp Asp Asp Asp Lys Asp 
            20                  25                  30          


Arg Trp Gly Ser Met Glu Thr Pro Pro Val Asn Thr Ile Gly Glu Lys 
        35                  40                  45              


Asp Thr Ser Gln Pro Gln Gln Glu Trp Glu Lys Asn Leu Arg Glu Asn 
    50                  55                  60                  


Leu Asp Ser Val Ile Gln Ile Arg Gln Gln Pro Arg Asp Pro Pro Thr 
65                  70                  75                  80  


Glu Thr Leu Glu Leu Glu Val Ser Pro Asp Pro Ala Ser Gln Ile Leu 
                85                  90                  95      


Glu His Thr Gln Gly Ala Glu Lys Leu Val Ala Glu Leu Glu Gly Asp 
            100                 105                 110         


Ser His Lys Ser His Gly Ser Thr Ser Gln Met Pro Glu Ala Leu Gln 
        115                 120                 125             


Ala Ser Asp Leu Trp Tyr Cys Pro Asp Gly Ser Phe Val Lys Lys Ile 
    130                 135                 140                 


Val Ile Arg Gly His Gly Leu Asp Lys Pro Lys Leu Gly Ser Cys Cys 
145                 150                 155                 160 


Arg Val Leu Ala Leu Gly Phe Pro Phe Gly Ser Gly Pro Pro Glu Gly 
                165                 170                 175     


Trp Thr Glu Leu Thr Met Gly Val Gly Pro Trp Arg Glu Glu Thr Trp 
            180                 185                 190         


Gly Glu Leu Ile Glu Lys Cys Leu Glu Ser Met Cys Gln Gly Glu Glu 
        195                 200                 205             


Ala Glu Leu Gln Leu Pro Gly His Thr Gly Pro Pro Val Gly Leu Thr 
    210                 215                 220                 


Leu Ala Ser Phe Thr Gln Gly Arg Asp Ser Trp Glu Leu Glu Thr Ser 
225                 230                 235                 240 


Glu Lys Glu Ala Leu Ala Arg Glu Glu Arg Ala Arg Gly Thr Glu Leu 
                245                 250                 255     


Phe Arg Ala Gly Asn Pro Glu Gly Ala Ala Arg Cys Tyr Gly Arg Ala 
            260                 265                 270         


Leu Arg Leu Leu Leu Thr Leu Pro Pro Pro Gly Pro Pro Glu Arg Thr 
        275                 280                 285             


Val Leu His Ala Asn Leu Ala Ala Cys Gln Leu Leu Leu Gly Gln Pro 
    290                 295                 300                 


Gln Leu Ala Ala Gln Ser Cys Asp Arg Val Leu Glu Arg Glu Pro Gly 
305                 310                 315                 320 


His Leu Lys Ala Leu Tyr Arg Arg Gly Val Ala Gln Ala Ala Leu Gly 
                325                 330                 335     


Asn Leu Glu Lys Ala Thr Ala Asp Leu Lys Lys Val Leu Ala Ile Asp 
            340                 345                 350         


Pro Lys Asn Arg Ala Ala Gln Glu Glu Leu Gly Lys Val Val Ile Gln 
        355                 360                 365             


Gly Lys Asn Gln Asp Ala Gly Leu Ala Gln Gly Leu Arg Lys Met Phe 
    370                 375                 380                 


Gly 
385 


<210>  2
<211>  349
<212>  PRT
<213>  Homo sapiens

<400>  2

Met Glu Thr Pro Pro Val Asn Thr Ile Gly Glu Lys Asp Thr Ser Gln 
1               5                   10                  15      


Pro Gln Gln Glu Trp Glu Lys Asn Leu Arg Glu Asn Leu Asp Ser Val 
            20                  25                  30          


Ile Gln Ile Arg Gln Gln Pro Arg Asp Pro Pro Thr Glu Thr Leu Glu 
        35                  40                  45              


Leu Glu Val Ser Pro Asp Pro Ala Ser Gln Ile Leu Glu His Thr Gln 
    50                  55                  60                  


Gly Ala Glu Lys Leu Val Ala Glu Leu Glu Gly Asp Ser His Lys Ser 
65                  70                  75                  80  


His Gly Ser Thr Ser Gln Met Pro Glu Ala Leu Gln Ala Ser Asp Leu 
                85                  90                  95      


Trp Tyr Cys Pro Asp Gly Ser Phe Val Lys Lys Ile Val Ile Arg Gly 
            100                 105                 110         


His Gly Leu Asp Lys Pro Lys Leu Gly Ser Cys Cys Arg Val Leu Ala 
        115                 120                 125             


Leu Gly Phe Pro Phe Gly Ser Gly Pro Pro Glu Gly Trp Thr Glu Leu 
    130                 135                 140                 


Thr Met Gly Val Gly Pro Trp Arg Glu Glu Thr Trp Gly Glu Leu Ile 
145                 150                 155                 160 


Glu Lys Cys Leu Glu Ser Met Cys Gln Gly Glu Glu Ala Glu Leu Gln 
                165                 170                 175     


Leu Pro Gly His Thr Gly Pro Pro Val Gly Leu Thr Leu Ala Ser Phe 
            180                 185                 190         


Thr Gln Gly Arg Asp Ser Trp Glu Leu Glu Thr Ser Glu Lys Glu Ala 
        195                 200                 205             


Leu Ala Arg Glu Glu Arg Ala Arg Gly Thr Glu Leu Phe Arg Ala Gly 
    210                 215                 220                 


Asn Pro Glu Gly Ala Ala Arg Cys Tyr Gly Arg Ala Leu Arg Leu Leu 
225                 230                 235                 240 


Leu Thr Leu Pro Pro Pro Gly Pro Pro Glu Arg Thr Val Leu His Ala 
                245                 250                 255     


Asn Leu Ala Ala Cys Gln Leu Leu Leu Gly Gln Pro Gln Leu Ala Ala 
            260                 265                 270         


Gln Ser Cys Asp Arg Val Leu Glu Arg Glu Pro Gly His Leu Lys Ala 
        275                 280                 285             


Leu Tyr Arg Arg Gly Val Ala Gln Ala Ala Leu Gly Asn Leu Glu Lys 
    290                 295                 300                 


Ala Thr Ala Asp Leu Lys Lys Val Leu Ala Ile Asp Pro Lys Asn Arg 
305                 310                 315                 320 


Ala Ala Gln Glu Glu Leu Gly Lys Val Val Ile Gln Gly Lys Asn Gln 
                325                 330                 335     


Asp Ala Gly Leu Ala Gln Gly Leu Arg Lys Met Phe Gly 
            340                 345                 


<210>  3
<211>  199
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Delta 200

<400>  3

Met Glu Thr Pro Pro Val Asn Thr Ile Gly Glu Lys Asp Thr Ser Gln 
1               5                   10                  15      


Pro Gln Gln Glu Trp Glu Lys Asn Leu Arg Glu Asn Leu Asp Ser Val 
            20                  25                  30          


Ile Gln Ile Arg Gln Gln Pro Arg Asp Pro Pro Thr Glu Thr Leu Glu 
        35                  40                  45              


Leu Glu Val Ser Pro Asp Pro Ala Ser Gln Ile Leu Glu His Thr Gln 
    50                  55                  60                  


Gly Ala Glu Lys Leu Val Ala Glu Leu Glu Gly Asp Ser His Lys Ser 
65                  70                  75                  80  


His Gly Ser Thr Ser Gln Met Pro Glu Ala Leu Gln Ala Ser Asp Leu 
                85                  90                  95      


Trp Tyr Cys Pro Asp Gly Ser Phe Val Lys Lys Ile Val Ile Arg Gly 
            100                 105                 110         


His Gly Leu Asp Lys Pro Lys Leu Gly Ser Cys Cys Arg Val Leu Ala 
        115                 120                 125             


Leu Gly Phe Pro Phe Gly Ser Gly Pro Pro Glu Gly Trp Thr Glu Leu 
    130                 135                 140                 


Thr Met Gly Val Gly Pro Trp Arg Glu Glu Thr Trp Gly Glu Leu Ile 
145                 150                 155                 160 


Glu Lys Cys Leu Glu Ser Met Cys Gln Gly Glu Glu Ala Glu Leu Gln 
                165                 170                 175     


Leu Pro Gly His Thr Gly Pro Pro Val Gly Leu Thr Leu Ala Ser Phe 
            180                 185                 190         


Thr Gln Gly Arg Asp Ser Trp 
        195                 


<210>  4
<211>  150
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Delta 151

<400>  4

Met Glu Thr Pro Pro Val Asn Thr Ile Gly Glu Lys Asp Thr Ser Gln 
1               5                   10                  15      


Pro Gln Gln Glu Trp Glu Lys Asn Leu Arg Glu Asn Leu Asp Ser Val 
            20                  25                  30          


Ile Gln Ile Arg Gln Gln Pro Arg Asp Pro Pro Thr Glu Thr Leu Glu 
        35                  40                  45              


Leu Glu Val Ser Pro Asp Pro Ala Ser Gln Ile Leu Glu His Thr Gln 
    50                  55                  60                  


Gly Ala Glu Lys Leu Val Ala Glu Leu Glu Gly Asp Ser His Lys Ser 
65                  70                  75                  80  


His Gly Ser Thr Ser Gln Met Pro Glu Ala Leu Gln Ala Ser Asp Leu 
                85                  90                  95      


Trp Tyr Cys Pro Asp Gly Ser Phe Val Lys Lys Ile Val Ile Arg Gly 
            100                 105                 110         


His Gly Leu Asp Lys Pro Lys Leu Gly Ser Cys Cys Arg Val Leu Ala 
        115                 120                 125             


Leu Gly Phe Pro Phe Gly Ser Gly Pro Pro Glu Gly Trp Thr Glu Leu 
    130                 135                 140                 


Thr Met Gly Val Gly Pro 
145                 150 


<210>  5
<211>  85
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Delta 86

<400>  5

Met Glu Thr Pro Pro Val Asn Thr Ile Gly Glu Lys Asp Thr Ser Gln 
1               5                   10                  15      


Pro Gln Gln Glu Trp Glu Lys Asn Leu Arg Glu Asn Leu Asp Ser Val 
            20                  25                  30          


Ile Gln Ile Arg Gln Gln Pro Arg Asp Pro Pro Thr Glu Thr Leu Glu 
        35                  40                  45              


Leu Glu Val Ser Pro Asp Pro Ala Ser Gln Ile Leu Glu His Thr Gln 
    50                  55                  60                  


Gly Ala Glu Lys Leu Val Ala Glu Leu Glu Gly Asp Ser His Lys Ser 
65                  70                  75                  80  


His Gly Ser Thr Ser 
                85  


<210>  6
<211>  57
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Delta 58

<400>  6

Met Glu Thr Pro Pro Val Asn Thr Ile Gly Glu Lys Asp Thr Ser Gln 
1               5                   10                  15      


Pro Gln Gln Glu Trp Glu Lys Asn Leu Arg Glu Asn Leu Asp Ser Val 
            20                  25                  30          


Ile Gln Ile Arg Gln Gln Pro Arg Asp Pro Pro Thr Glu Thr Leu Glu 
        35                  40                  45              


Leu Glu Val Ser Pro Asp Pro Ala Ser 
    50                  55          


<210>  7
<211>  47
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Delta 48

<400>  7

Met Glu Thr Pro Pro Val Asn Thr Ile Gly Glu Lys Asp Thr Ser Gln 
1               5                   10                  15      


Pro Gln Gln Glu Trp Glu Lys Asn Leu Arg Glu Asn Leu Asp Ser Val 
            20                  25                  30          


Ile Gln Ile Arg Gln Gln Pro Arg Asp Pro Pro Thr Glu Thr Leu 
        35                  40                  45          


<210>  8
<211>  39
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Delta 40

<400>  8

Met Glu Thr Pro Pro Val Asn Thr Ile Gly Glu Lys Asp Thr Ser Gln 
1               5                   10                  15      


Pro Gln Gln Glu Trp Glu Lys Asn Leu Arg Glu Asn Leu Asp Ser Val 
            20                  25                  30          


Ile Gln Ile Arg Gln Gln Pro 
        35                  


<210>  9
<211>  33
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Delta 34

<400>  9

Met Glu Thr Pro Pro Val Asn Thr Ile Gly Glu Lys Asp Thr Ser Gln 
1               5                   10                  15      


Pro Gln Gln Glu Trp Glu Lys Asn Leu Arg Glu Asn Leu Asp Ser Val 
            20                  25                  30          


Ile 
    


<210>  10
<211>  24
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AD-01


<220>
<221>  MISC_FEATURE
<222>  (1)..()
<223>  NH2

<220>
<221>  MISC_FEATURE
<222>  (23)..()
<223>  OH

<400>  10

Gln Ile Arg Gln Gln Pro Arg Asp Pro Pro Thr Glu Thr Leu Glu Leu 
1               5                   10                  15      


Glu Val Ser Pro Asp Pro Ala Ser 
            20                  


<210>  11
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  peptide

<400>  11

Gln Gln Pro Arg Asp Pro Pro Thr Glu Thr Leu Glu Leu Glu Val Ser 
1               5                   10                  15      


Pro Asp 
        


<210>  12
<211>  25
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  peptide 1

<400>  12

Gln Ile Arg Gln Gln Pro Arg Asp Pro Pro Thr Glu Thr Leu Glu Leu 
1               5                   10                  15      


Glu Val Ser Pro Asp Pro Ala Ser Cys 
            20                  25  


<210>  13
<211>  24
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  peptide 2

<400>  13

Glu Ile Arg Gln Gln Pro Arg Asp Pro Pro Thr Glu Thr Leu Glu Leu 
1               5                   10                  15      


Glu Val Ser Pro Asp Pro Ala Ser 
            20                  


<210>  14
<211>  23
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  peptide 3

<400>  14

Ile Arg Gln Gln Pro Arg Asp Pro Pro Thr Glu Thr Leu Glu Leu Glu 
1               5                   10                  15      


Val Ser Pro Asp Pro Ala Ser 
            20              


<210>  15
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  peptide 4

<400>  15

Gln Ile Arg Gln Gln Pro Arg Asp Pro Pro Thr Glu Thr Leu Glu Leu 
1               5                   10                  15      


Glu Val Ser Pro Asp 
            20      


<210>  16
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  peptide 5

<400>  16

Gln Ile Arg Gln Gln Pro Arg Asp Pro Pro Thr Glu Thr Leu Glu Leu 
1               5                   10                  15      


Glu Val 
        


<210>  17
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  peptide 6

<400>  17

Gln Ile Arg Gln Gln Pro Arg Asp Pro Pro Thr Glu Thr Leu Glu 
1               5                   10                  15  


<210>  18
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  peptide 7

<400>  18

Gln Ile Arg Gln Gln Pro Arg Asp Pro Pro Thr Glu 
1               5                   10          


<210>  19
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  peptide 8

<400>  19

Gln Gln Pro Arg Asp Pro Pro Thr Glu Thr Leu Glu Leu Glu Val Ser 
1               5                   10                  15      


Pro Asp Pro Ala Ser 
            20      


<210>  20
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  peptide 9

<400>  20

Arg Asp Pro Pro Thr Glu Thr Leu Glu Leu Glu Val Ser Pro Asp Pro 
1               5                   10                  15      


Ala Ser 
        


<210>  21
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  peptide 10

<400>  21

Pro Thr Glu Thr Leu Glu Leu Glu Val Ser Pro Asp Pro Ala Ser 
1               5                   10                  15  


<210>  22
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  peptide 11

<400>  22

Thr Leu Glu Leu Glu Val Ser Pro Asp Pro Ala Ser 
1               5                   10          


<210>  23
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  peptide 12

<400>  23

Arg Gln Gln Pro Arg Asp Pro Pro Thr Glu Thr Leu Glu Leu Glu Val 
1               5                   10                  15      


Ser Pro Asp 
            


<210>  24
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  peptide 13

<400>  24

Arg Gln Gln Pro Arg Asp Pro Pro Thr Glu Thr Leu Glu Leu Glu Val 
1               5                   10                  15      


Ser Pro 
        


<210>  25
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  peptide 14

<400>  25

Arg Gln Gln Pro Arg Asp Pro Pro Thr Glu Thr Leu Glu Leu Glu Val 
1               5                   10                  15      


Ser 
    


<210>  26
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  peptide 15

<400>  26

Pro Arg Asp Pro Pro Thr Glu Thr Leu Glu Leu Glu Val Ser Pro Asp 
1               5                   10                  15      


<210>  27
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  peptide 16

<400>  27

Arg Asp Pro Pro Thr Glu Thr Leu Glu Leu Glu Val Ser Pro Asp 
1               5                   10                  15  


<210>  28
<211>  24
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  peptide 17

<400>  28

Gln Ile Arg Gln Gln Pro Arg Asp Pro Pro Thr Glu Thr Leu Glu Leu 
1               5                   10                  15      


Glu Val Ser Pro Asp Pro Ala Ser 
            20                  


<210>  29
<211>  349
<212>  PRT
<213>  Homo sapiens

<400>  29

Met Glu Thr Pro Pro Val Asn Thr Ile Gly Glu Lys Asp Thr Ser Gln 
1               5                   10                  15      


Pro Gln Gln Glu Trp Glu Lys Asn Leu Arg Glu Asn Leu Asp Ser Val 
            20                  25                  30          


Ile Gln Ile Arg Gln Gln Pro Arg Asp Pro Pro Thr Glu Thr Leu Glu 
        35                  40                  45              


Leu Glu Val Ser Pro Asp Pro Ala Ser Gln Ile Leu Glu His Thr Gln 
    50                  55                  60                  


Gly Ala Glu Lys Leu Val Ala Glu Leu Glu Gly Asp Ser His Lys Ser 
65                  70                  75                  80  


His Gly Ser Thr Ser Gln Met Pro Glu Ala Leu Gln Ala Ser Asp Leu 
                85                  90                  95      


Trp Tyr Cys Pro Asp Gly Ser Phe Val Lys Lys Ile Val Ile Arg Gly 
            100                 105                 110         


His Gly Leu Asp Lys Pro Lys Leu Gly Ser Cys Cys Arg Val Leu Ala 
        115                 120                 125             


Leu Gly Phe Pro Phe Gly Ser Gly Pro Pro Glu Gly Trp Thr Glu Leu 
    130                 135                 140                 


Thr Met Gly Val Gly Pro Trp Arg Glu Glu Thr Trp Gly Glu Leu Ile 
145                 150                 155                 160 


Glu Lys Cys Leu Glu Ser Met Cys Gln Gly Glu Glu Ala Glu Leu Gln 
                165                 170                 175     


Leu Pro Gly His Ser Gly Pro Pro Val Arg Leu Thr Leu Ala Ser Phe 
            180                 185                 190         


Thr Gln Gly Arg Asp Ser Trp Glu Leu Glu Thr Ser Glu Lys Glu Ala 
        195                 200                 205             


Leu Ala Arg Glu Glu Arg Ala Arg Gly Thr Glu Leu Phe Arg Ala Gly 
    210                 215                 220                 


Asn Pro Glu Gly Ala Ala Arg Cys Tyr Gly Arg Ala Leu Arg Leu Leu 
225                 230                 235                 240 


Leu Thr Leu Pro Pro Pro Gly Pro Pro Glu Arg Thr Val Leu His Ala 
                245                 250                 255     


Asn Leu Ala Ala Cys Gln Leu Leu Leu Gly Gln Pro Gln Leu Ala Ala 
            260                 265                 270         


Gln Ser Cys Asp Arg Val Leu Glu Arg Glu Pro Gly His Leu Lys Ala 
        275                 280                 285             


Leu Tyr Arg Arg Gly Val Ala Gln Ala Ala Leu Gly Asn Leu Glu Lys 
    290                 295                 300                 


Ala Thr Ala Asp Leu Lys Lys Val Leu Ala Ile Asp Pro Lys Asn Arg 
305                 310                 315                 320 


Ala Ala Gln Glu Glu Leu Gly Lys Val Val Ile Gln Gly Lys Asn Gln 
                325                 330                 335     


Asp Ala Gly Leu Ala Gln Gly Leu Arg Lys Met Phe Gly 
            340                 345                 


<210>  30
<211>  1050
<212>  DNA
<213>  Homo sapiens

<400>  30
atggagacgc caccagtcaa tacaattgga gaaaaggaca cctctcagcc gcaacaagag       60

tgggaaaaga accttcggga gaaccttgat tcagttattc agattaggca gcagccccga      120

gaccctccta ccgaaacgct tgagctggaa gtaagcccag atccagccag ccaaattcta      180

gagcatactc aaggagctga aaaactggtt gctgaacttg aaggagactc tcataagtct      240

catggatcaa ccagtcagat gccagaggcc cttcaagctt ctgatctctg gtactgcccc      300

gatgggagct ttgtcaagaa gatcgtaatc cgtggccatg gcttggacaa acccaaacta      360

ggctcctgct gccgggtact ggctttgggg tttcctttcg gatcagggcc gccagagggc      420

tggacagagc taactatggg cgtagggcca tggagggagg aaacttgggg ggagctcata      480

gagaaatgct tggagtccat gtgtcaaggt gaggaagcag agcttcagct gcctgggcac      540

tctggacctc ctgtcaggct cacactggca tccttcactc aaggccgaga ctcctgggag      600

ctggagacta gcgagaagga agccctggcc agggaagaac gtgcaagggg cacagaacta      660

tttcgagctg ggaaccctga aggagctgcc cgatgctatg gacgggctct tcggctgctc      720

ctgactttac ccccacctgg ccctccagaa cgaactgtcc ttcatgccaa tctggctgcc      780

tgtcagttgt tgctagggca gcctcagttg gcagcccaga gctgtgaccg ggtgttggag      840

cgggagcctg gccatttaaa ggccttatac cgaagggggg ttgcccaggc tgcccttggg      900

aacctggaaa aagcaactgc tgacctcaag aaggtgctgg cgatagatcc caaaaaccgg      960

gcagcccagg aggaactggg gaaggtggtc attcagggga agaaccagga tgcagggctg     1020

gctcagggtc tgcgcaagat gtttggctga                                      1050


<210>  31
<211>  1050
<212>  DNA
<213>  Homo sapiens

<400>  31
atggagacgc caccagtcaa tacaattgga gaaaaggaca cctctcagcc gcaacaagag       60

tgggaaaaga accttcggga gaaccttgat tcagttattc agattaggca gcagccccga      120

gaccctccta ccgaaacgct tgagctggaa gtaagcccag atccagccag ccaaattcta      180

gagcatactc aaggagctga aaaactggtt gctgaacttg aaggagactc tcataagtct      240

catggatcaa ccagtcagat gccagaggcc cttcaagctt ctgatctctg gtactgcccc      300

gatgggagct ttgtcaagaa gatcgtaatc cgtggccatg gcttggacaa acccaaacta      360

ggctcctgct gccgggtact ggctttgggg tttcctttcg gatcagggcc gccagagggc      420

tggacagagc taactatggg cgtagggcca tggagggagg aaacttgggg ggagctcata      480

gagaaatgct tggagtccat gtgtcaaggt gaggaagcag agcttcagct gcctgggcac      540

actggacctc ctgtcgggct cacactggca tccttcactc aaggccgaga ctcctgggag      600

ctggagacta gcgagaagga agccctggcc agggaagaac gtgcaagggg cacagaacta      660

tttcgagctg ggaaccctga aggagctgcc cgatgctatg gacgggctct tcggctgctc      720

ctgactttac ccccacctgg ccctccagaa cgaactgtcc ttcatgccaa tctggctgcc      780

tgtcagttgt tgctagggca gcctcagttg gcagcccaga gctgtgaccg ggtgttggag      840

cgggagcctg gccatttaaa ggccttatac cgaagggggg ttgcccaggc tgcccttggg      900

aacctggaaa aagcaactgc tgacctcaag aaggtgctgg cgatagatcc caaaaaccgg      960

gcagcccagg aggaactggg gaaggtggtc attcagggga agaaccagga tgcagggctg     1020

gctcagggtc tgcgcaagat gtttggctga                                      1050


<210>  32
<211>  102
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Delta 34

<400>  32
atggagacgc caccagtcaa tacaattgga gaaaaggaca cctctcagcc gcaacaagag       60

tgggaaaaga accttcggga gaaccttgat tcagttattt ag                         102


<210>  33
<211>  119
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Delta 40

<400>  33
atggagacgc caccagtcaa tacaattgga gaaaaggaca cctctcagcc gcaacaagag       60

tgggaaaaga accttcggga gaaccttgat tcagttattc agattaggca gcagccccg       119


<210>  34
<211>  143
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Delta 48

<400>  34
atggagacgc caccagtcaa tacaattgga gaaaaggaca cctctcagcc gcaacaagag       60

tgggaaaaga accttcggga gaaccttgat tcagttattc agattaggca gcagccccga      120

gaccctccta ccgaaacgct tga                                              143


<210>  35
<211>  174
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Delta 58

<400>  35
atggagacgc caccagtcaa tacaattgga gaaaaggaca cctctcagcc gcaacaagag       60

tgggaaaaga accttcggga gaaccttgat tcagttattc agattaggca gcagccccga      120

gaccctccta ccgaaacgct tgagctggaa gtaagcccag atccagccag ctaa            174


<210>  36
<211>  258
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Delta 86

<400>  36
atggagacgc caccagtcaa tacaattgga gaaaaggaca cctctcagcc gcaacaagag       60

tgggaaaaga accttcggga gaaccttgat tcagttattc agattaggca gcagccccga      120

gaccctccta ccgaaacgct tgagctggaa gtaagcccag atccagccag ccaaattcta      180

gagcatactc aaggagctga aaaactggtt gctgaacttg aaggagactc tcataagtct      240

catggatcaa ccagttag                                                    258


<210>  37
<211>  453
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Delta 151

<400>  37
atggagacgc caccagtcaa tacaattgga gaaaaggaca cctctcagcc gcaacaagag       60

tgggaaaaga accttcggga gaaccttgat tcagttattc agattaggca gcagccccga      120

gaccctccta ccgaaacgct tgagctggaa gtaagcccag atccagccag ccaaattcta      180

gagcatactc aaggagctga aaaactggtt gctgaacttg aaggagactc tcataagtct      240

catggatcaa ccagtcagat gccagaggcc cttcaagctt ctgatctctg gtactgcccc      300

gatgggagct ttgtcaagaa gatcgtaatc cgtggccatg gcttggacaa acccaaacta      360

ggctcctgct gccgggtact ggctttgggg tttcctttcg gatcagggcc gccagagggc      420

tggacagagc taactatggg cgtagggcca tga                                   453


<210>  38
<211>  600
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Delta 200

<400>  38
atggagacgc caccagtcaa tacaattgga gaaaaggaca cctctcagcc gcaacaagag       60

tgggaaaaga accttcggga gaaccttgat tcagttattc agattaggca gcagccccga      120

gaccctccta ccgaaacgct tgagctggaa gtaagcccag atccagccag ccaaattcta      180

gagcatactc aaggagctga aaaactggtt gctgaacttg aaggagactc tcataagtct      240

catggatcaa ccagtcagat gccagaggcc cttcaagctt ctgatctctg gtactgcccc      300

gatgggagct ttgtcaagaa gatcgtaatc cgtggccatg gcttggacaa acccaaacta      360

ggctcctgct gccgggtact ggctttgggg tttcctttcg gatcagggcc gccagagggc      420

tggacagagc taactatggg cgtagggcca tggagggagg aaacttgggg ggagctcata      480

gagaaatgct tggagtccat gtgtcaaggt gaggaagcag agcttcagct gcctgggcac      540

tctggacctc ctgtcaggct cacactggca tccttcactc aaggccgaga ctcctggtag      600


<210>  39
<211>  600
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Delta 200 cloned

<400>  39
atggagacgc caccagtcaa tacaattgga gaaaaggaca cctctcagcc gcaacaagag       60

tgggaaaaga accttcggga gaaccttgat tcagttattc agattaggca gcagccccga      120

gaccctccta ccgaaacgct tgagctggaa gtaagcccag atccagccag ccaaattcta      180

gagcatactc aaggagctga aaaactggtt gctgaacttg aaggagactc tcataagtct      240

catggatcaa ccagtcagat gccagaggcc cttcaagctt ctgatctctg gtactgcccc      300

gatgggagct ttgtcaagaa gatcgtaatc cgtggccatg gcttggacaa acccaaacta      360

ggctcctgct gccgggtact ggctttgggg tttcctttcg gatcagggcc gccagagggc      420

tggacagagc taactatggg cgtagggcca tggagggagg aaacttgggg ggagctcata      480

gagaaatgct tggagtccat gtgtcaaggt gaggaagcag agcttcagct gcctgggcac      540

actggacctc ctgtcgggct cacactggca tccttcactc aaggccgaga ctcctggtag      600


<210>  40
<211>  23
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ALM201


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  NH2

<220>
<221>  MISC_FEATURE
<222>  (23)..(1)
<223>  OH

<400>  40

Ile Arg Gln Gln Pro Arg Asp Pro Pro Thr Glu Thr Leu Glu Leu Glu 
1               5                   10                  15      


Val Ser Pro Asp Pro Ala Ser 
            20              


<210>  41
<211>  25
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  SiRNA F1

<400>  41
ggagacgcca ccagucaaua caauu                                             25


<210>  42
<211>  25
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  siRNA F2

<400>  42
gcugaacuug aaggagacuc ucaua                                             25


<210>  43
<211>  25
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  siRNAF3

<400>  43
cagccaaauu cuagagcaua cucaa                                             25


