                         SEQUENCE LISTING

<110>  Lysando AG
 
<120>  New antimicrobial agents against Enterococcus bacteria

<130>  LYS-044 PCT

<150>  EP16194788
<151>  2016-10-20

<160>  105   

<170>  PatentIn version 3.5

<210>  1
<211>  314
<212>  PRT
<213>  Enterococcal bacteriophage phi1

<400>  1

Met Ser Asn Ile Asn Met Glu Thr Ala Ile Ala Asn Met Tyr Ala Leu 
1               5                   10                  15      


Lys Ala Arg Gly Ile Thr Tyr Ser Met Asn Tyr Ser Arg Thr Gly Ala 
            20                  25                  30          


Asp Gly Thr Gly Asp Cys Ser Gly Thr Val Tyr Asp Ser Leu Arg Lys 
        35                  40                  45              


Ala Gly Ala Ser Asp Ala Gly Trp Val Leu Asn Thr Asp Ser Met His 
    50                  55                  60                  


Ser Trp Leu Glu Lys Asn Gly Phe Lys Leu Ile Ala Gln Asn Lys Glu 
65                  70                  75                  80  


Trp Ser Ala Lys Arg Gly Asp Val Val Ile Phe Gly Lys Lys Gly Ala 
                85                  90                  95      


Ser Gly Gly Ser Ala Gly His Val Val Ile Phe Ile Ser Ser Thr Gln 
            100                 105                 110         


Ile Ile His Cys Thr Trp Lys Ser Ala Thr Ala Asn Gly Val Tyr Val 
        115                 120                 125             


Asp Asn Glu Ala Thr Thr Cys Pro Tyr Ser Met Gly Trp Tyr Val Tyr 
    130                 135                 140                 


Arg Leu Asn Gly Gly Ser Thr Pro Pro Lys Pro Asn Thr Lys Lys Val 
145                 150                 155                 160 


Lys Val Leu Lys His Ala Thr Asn Trp Ser Pro Ser Ser Lys Gly Ala 
                165                 170                 175     


Lys Met Ala Ser Phe Val Lys Gly Gly Thr Phe Glu Val Lys Gln Gln 
            180                 185                 190         


Arg Pro Ile Ser Tyr Ser Tyr Ser Asn Gln Glu Tyr Leu Ile Val Asn 
        195                 200                 205             


Lys Gly Thr Val Leu Gly Trp Val Leu Ser Gln Asp Ile Glu Gly Gly 
    210                 215                 220                 


Tyr Gly Ser Asp Arg Val Gly Gly Ser Lys Pro Lys Leu Pro Ala Gly 
225                 230                 235                 240 


Phe Thr Lys Glu Glu Ala Thr Phe Ile Asn Gly Asn Ala Pro Ile Thr 
                245                 250                 255     


Thr Arg Lys Asn Lys Pro Ser Leu Ser Ser Gln Thr Ala Thr Pro Leu 
            260                 265                 270         


Tyr Pro Gly Gln Ser Val Arg Tyr Leu Gly Trp Lys Ser Ala Glu Gly 
        275                 280                 285             


Tyr Ile Trp Ile Tyr Ala Thr Asp Gly Arg Tyr Ile Pro Val Arg Pro 
    290                 295                 300                 


Val Gly Lys Glu Ala Trp Gly Thr Phe Lys 
305                 310                 


<210>  2
<211>  150
<212>  PRT
<213>  Enterococcal bacteriophage phi1

<400>  2

Ile Asn Met Glu Thr Ala Ile Ala Asn Met Tyr Ala Leu Lys Ala Arg 
1               5                   10                  15      


Gly Ile Thr Tyr Ser Met Asn Tyr Ser Arg Thr Gly Ala Asp Gly Thr 
            20                  25                  30          


Gly Asp Cys Ser Gly Thr Val Tyr Asp Ser Leu Arg Lys Ala Gly Ala 
        35                  40                  45              


Ser Asp Ala Gly Trp Val Leu Asn Thr Asp Ser Met His Ser Trp Leu 
    50                  55                  60                  


Glu Lys Asn Gly Phe Lys Leu Ile Ala Gln Asn Lys Glu Trp Ser Ala 
65                  70                  75                  80  


Lys Arg Gly Asp Val Val Ile Phe Gly Lys Lys Gly Ala Ser Gly Gly 
                85                  90                  95      


Ser Ala Gly His Val Val Ile Phe Ile Ser Ser Thr Gln Ile Ile His 
            100                 105                 110         


Cys Thr Trp Lys Ser Ala Thr Ala Asn Gly Val Tyr Val Asp Asn Glu 
        115                 120                 125             


Ala Thr Thr Cys Pro Tyr Ser Met Gly Trp Tyr Val Tyr Arg Leu Asn 
    130                 135                 140                 


Gly Gly Ser Thr Pro Pro 
145                 150 


<210>  3
<211>  65
<212>  PRT
<213>  Enterococcal bacteriophage phi1

<400>  3

Glu Ala Thr Phe Ile Asn Gly Asn Ala Pro Ile Thr Thr Arg Lys Asn 
1               5                   10                  15      


Lys Pro Ser Leu Ser Ser Gln Thr Ala Thr Pro Leu Tyr Pro Gly Gln 
            20                  25                  30          


Ser Val Arg Tyr Leu Gly Trp Lys Ser Ala Glu Gly Tyr Ile Trp Ile 
        35                  40                  45              


Tyr Ala Thr Asp Gly Arg Tyr Ile Pro Val Arg Pro Val Gly Lys Glu 
    50                  55                  60                  


Ala 
65  


<210>  4
<211>  21
<212>  PRT
<213>  unknown

<220>
<223>  Buforin II vertebrate

<400>  4

Thr Arg Ser Ser Arg Ala Gly Leu Gln Phe Pro Val Gly Arg Val His 
1               5                   10                  15      


Arg Leu Leu Arg Lys 
            20      


<210>  5
<211>  313
<212>  PRT
<213>  Enterococcal bacteriophage phi1

<400>  5

Ser Asn Ile Asn Met Glu Thr Ala Ile Ala Asn Met Tyr Ala Leu Lys 
1               5                   10                  15      


Ala Arg Gly Ile Thr Tyr Ser Met Asn Tyr Ser Arg Thr Gly Ala Asp 
            20                  25                  30          


Gly Thr Gly Asp Cys Ser Gly Thr Val Tyr Asp Ser Leu Arg Lys Ala 
        35                  40                  45              


Gly Ala Ser Asp Ala Gly Trp Val Leu Asn Thr Asp Ser Met His Ser 
    50                  55                  60                  


Trp Leu Glu Lys Asn Gly Phe Lys Leu Ile Ala Gln Asn Lys Glu Trp 
65                  70                  75                  80  


Ser Ala Lys Arg Gly Asp Val Val Ile Phe Gly Lys Lys Gly Ala Ser 
                85                  90                  95      


Gly Gly Ser Ala Gly His Val Val Ile Phe Ile Ser Ser Thr Gln Ile 
            100                 105                 110         


Ile His Cys Thr Trp Lys Ser Ala Thr Ala Asn Gly Val Tyr Val Asp 
        115                 120                 125             


Asn Glu Ala Thr Thr Cys Pro Tyr Ser Met Gly Trp Tyr Val Tyr Arg 
    130                 135                 140                 


Leu Asn Gly Gly Ser Thr Pro Pro Lys Pro Asn Thr Lys Lys Val Lys 
145                 150                 155                 160 


Val Leu Lys His Ala Thr Asn Trp Ser Pro Ser Ser Lys Gly Ala Lys 
                165                 170                 175     


Met Ala Ser Phe Val Lys Gly Gly Thr Phe Glu Val Lys Gln Gln Arg 
            180                 185                 190         


Pro Ile Ser Tyr Ser Tyr Ser Asn Gln Glu Tyr Leu Ile Val Asn Lys 
        195                 200                 205             


Gly Thr Val Leu Gly Trp Val Leu Ser Gln Asp Ile Glu Gly Gly Tyr 
    210                 215                 220                 


Gly Ser Asp Arg Val Gly Gly Ser Lys Pro Lys Leu Pro Ala Gly Phe 
225                 230                 235                 240 


Thr Lys Glu Glu Ala Thr Phe Ile Asn Gly Asn Ala Pro Ile Thr Thr 
                245                 250                 255     


Arg Lys Asn Lys Pro Ser Leu Ser Ser Gln Thr Ala Thr Pro Leu Tyr 
            260                 265                 270         


Pro Gly Gln Ser Val Arg Tyr Leu Gly Trp Lys Ser Ala Glu Gly Tyr 
        275                 280                 285             


Ile Trp Ile Tyr Ala Thr Asp Gly Arg Tyr Ile Pro Val Arg Pro Val 
    290                 295                 300                 


Gly Lys Glu Ala Trp Gly Thr Phe Lys 
305                 310             


<210>  6
<211>  6
<212>  PRT
<213>  artificial

<220>
<223>  synthetic sequence

<400>  6

Lys Arg Lys Lys Arg Lys 
1               5       


<210>  7
<211>  5
<212>  PRT
<213>  artificial

<220>
<223>  synethtic sequence


<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  Xaa can be any naturally occurring amino acid

<400>  7

Lys Arg Xaa Lys Arg 
1               5   


<210>  8
<211>  5
<212>  PRT
<213>  artificial

<220>
<223>  synthetic sequence

<400>  8

Lys Arg Ser Lys Arg 
1               5   


<210>  9
<211>  5
<212>  PRT
<213>  artificial

<220>
<223>  synthetic sequence

<400>  9

Lys Arg Gly Ser Gly 
1               5   


<210>  10
<211>  9
<212>  PRT
<213>  artificial

<220>
<223>  synthetic sequence

<400>  10

Lys Arg Lys Lys Arg Lys Lys Arg Lys 
1               5                   


<210>  11
<211>  9
<212>  PRT
<213>  artificial

<220>
<223>  synthetic sequence

<400>  11

Arg Arg Arg Arg Arg Arg Arg Arg Arg 
1               5                   


<210>  12
<211>  8
<212>  PRT
<213>  artificial

<220>
<223>  synthetic sequence

<400>  12

Lys Lys Lys Lys Lys Lys Lys Lys 
1               5               


<210>  13
<211>  10
<212>  PRT
<213>  artificial

<220>
<223>  synthetic sequence

<400>  13

Lys Arg Lys Lys Arg Lys Lys Arg Lys Lys 
1               5                   10  


<210>  14
<211>  12
<212>  PRT
<213>  artificial

<220>
<223>  synthetic sequence

<400>  14

Lys Arg Lys Lys Arg Lys Lys Arg Lys Lys Arg Lys 
1               5                   10          


<210>  15
<211>  14
<212>  PRT
<213>  artificial

<220>
<223>  synthetic sequence

<400>  15

Lys Arg Lys Lys Arg Lys Lys Arg Lys Lys Arg Lys Lys Arg 
1               5                   10                  


<210>  16
<211>  16
<212>  PRT
<213>  artificial

<220>
<223>  synthetic sequence

<400>  16

Lys Lys Lys Lys Lys Lys Lys Lys Lys Lys Lys Lys Lys Lys Lys Lys 
1               5                   10                  15      


<210>  17
<211>  18
<212>  PRT
<213>  artificial

<220>
<223>  synthetic sequence

<400>  17

Lys Arg Lys Lys Arg Lys Lys Arg Lys Lys Arg Lys Lys Arg Lys Lys 
1               5                   10                  15      


Arg Lys 
        


<210>  18
<211>  19
<212>  PRT
<213>  artificial

<220>
<223>  synthetic sequence

<400>  18

Lys Arg Lys Lys Arg Lys Lys Arg Lys Lys Arg Lys Lys Arg Lys Lys 
1               5                   10                  15      


Arg Lys Lys 
            


<210>  19
<211>  19
<212>  PRT
<213>  artificial

<220>
<223>  synthetic sequence

<400>  19

Arg Arg Arg Arg Arg Arg Arg Arg Arg Arg Arg Arg Arg Arg Arg Arg 
1               5                   10                  15      


Arg Arg Arg 
            


<210>  20
<211>  19
<212>  PRT
<213>  artificial

<220>
<223>  synthetic sequence

<400>  20

Lys Lys Lys Lys Lys Lys Lys Lys Lys Lys Lys Lys Lys Lys Lys Lys 
1               5                   10                  15      


Lys Lys Lys 
            


<210>  21
<211>  20
<212>  PRT
<213>  artificial

<220>
<223>  synthetic sequence

<400>  21

Lys Arg Lys Lys Arg Lys Lys Arg Lys Arg Ser Lys Arg Lys Lys Arg 
1               5                   10                  15      


Lys Lys Arg Lys 
            20  


<210>  22
<211>  21
<212>  PRT
<213>  artificial

<220>
<223>  synthetic sequence

<400>  22

Lys Arg Lys Lys Arg Lys Lys Arg Lys Arg Ser Lys Arg Lys Lys Arg 
1               5                   10                  15      


Lys Lys Arg Lys Lys 
            20      


<210>  23
<211>  21
<212>  PRT
<213>  artificial

<220>
<223>  synthetic sequence

<400>  23

Lys Arg Lys Lys Arg Lys Lys Arg Lys Lys Arg Lys Lys Arg Lys Lys 
1               5                   10                  15      


Arg Lys Lys Arg Lys 
            20      


<210>  24
<211>  22
<212>  PRT
<213>  artificial

<220>
<223>  synthetic sequence

<400>  24

Lys Arg Lys Lys Arg Lys Lys Arg Lys Arg Gly Ser Gly Lys Arg Lys 
1               5                   10                  15      


Lys Arg Lys Lys Arg Lys 
            20          


<210>  25
<211>  24
<212>  PRT
<213>  artificial

<220>
<223>  synthetic sequence

<400>  25

Lys Arg Lys Lys Arg Lys Lys Arg Lys Arg Gly Ser Gly Ser Gly Lys 
1               5                   10                  15      


Arg Lys Lys Arg Lys Lys Arg Lys 
            20                  


<210>  26
<211>  25
<212>  PRT
<213>  artificial

<220>
<223>  synthetic sequence

<400>  26

Lys Arg Lys Lys Arg Lys Lys Arg Lys Lys Arg Lys Lys Arg Lys Lys 
1               5                   10                  15      


Arg Lys Lys Arg Lys Lys Arg Lys Lys 
            20                  25  


<210>  27
<211>  31
<212>  PRT
<213>  artificial

<220>
<223>  synthetic sequence

<400>  27

Lys Arg Lys Lys Arg Lys Lys Arg Lys Arg Ser Lys Arg Lys Lys Arg 
1               5                   10                  15      


Lys Lys Arg Lys Arg Ser Lys Arg Lys Lys Arg Lys Lys Arg Lys 
            20                  25                  30      


<210>  28
<211>  38
<212>  PRT
<213>  artificial

<220>
<223>  synthetic sequence

<400>  28

Lys Arg Lys Lys Arg Lys Lys Arg Lys Arg Gly Ser Gly Ser Gly Lys 
1               5                   10                  15      


Arg Lys Lys Arg Lys Lys Arg Lys Gly Ser Gly Ser Gly Lys Arg Lys 
            20                  25                  30          


Lys Arg Lys Lys Arg Lys 
        35              


<210>  29
<211>  39
<212>  PRT
<213>  artificial

<220>
<223>  synthetic sequence

<400>  29

Lys Arg Lys Lys Arg Lys Lys Arg Lys Lys Arg Lys Lys Arg Lys Lys 
1               5                   10                  15      


Arg Lys Lys Arg Lys Lys Arg Lys Lys Arg Lys Lys Arg Lys Lys Arg 
            20                  25                  30          


Lys Lys Arg Lys Lys Arg Lys 
        35                  


<210>  30
<211>  42
<212>  PRT
<213>  artificial

<220>
<223>  synthetic sequence

<400>  30

Lys Arg Lys Lys Arg Lys Lys Arg Lys Arg Ser Lys Arg Lys Lys Arg 
1               5                   10                  15      


Lys Lys Arg Lys Arg Ser Lys Arg Lys Lys Arg Lys Lys Arg Lys Arg 
            20                  25                  30          


Ser Lys Arg Lys Lys Arg Lys Lys Arg Lys 
        35                  40          


<210>  31
<211>  37
<212>  PRT
<213>  Homo sapiens

<400>  31

Leu Leu Gly Asp Phe Phe Arg Lys Ser Lys Glu Lys Ile Gly Lys Glu 
1               5                   10                  15      


Phe Lys Arg Ile Val Gln Arg Ile Lys Asp Phe Leu Arg Asn Leu Val 
            20                  25                  30          


Pro Arg Thr Glu Ser 
        35          


<210>  32
<211>  29
<212>  PRT
<213>  unknown

<220>
<223>  SMAP-29 sheep

<400>  32

Arg Gly Leu Arg Arg Leu Gly Arg Lys Ile Ala His Gly Val Lys Lys 
1               5                   10                  15      


Tyr Gly Pro Thr Val Leu Arg Ile Ile Arg Ile Ala Gly 
            20                  25                  


<210>  33
<211>  13
<212>  PRT
<213>  unknown

<220>
<223>  Indolicidine bovine

<400>  33

Ile Leu Pro Trp Lys Trp Pro Trp Trp Pro Trp Arg Arg 
1               5                   10              


<210>  34
<211>  18
<212>  PRT
<213>  unknown

<220>
<223>  Protegrin Porcine

<400>  34

Arg Gly Gly Arg Leu Cys Tyr Cys Arg Arg Arg Phe Cys Val Cys Val 
1               5                   10                  15      


Gly Arg 
        


<210>  35
<211>  31
<212>  PRT
<213>  unknown

<220>
<223>  Cecropin P1 Mammal (pig)

<400>  35

Ser Trp Leu Ser Lys Thr Ala Lys Lys Leu Glu Asn Ser Ala Lys Lys 
1               5                   10                  15      


Arg Ile Ser Glu Gly Ile Ala Ile Ala Ile Gln Gly Gly Pro Arg 
            20                  25                  30      


<210>  36
<211>  23
<212>  PRT
<213>  unknown

<220>
<223>  Magainin frog

<400>  36

Gly Ile Gly Lys Phe Leu His Ser Ala Lys Lys Phe Gly Lys Ala Phe 
1               5                   10                  15      


Val Gly Glu Ile Met Asn Ser 
            20              


<210>  37
<211>  25
<212>  PRT
<213>  unknown

<220>
<223>  Pleurocidin fish

<400>  37

Gly Trp Gly Ser Phe Phe Lys Lys Ala Ala His Val Gly Lys His Val 
1               5                   10                  15      


Gly Lys Ala Ala Leu Thr His Tyr Leu 
            20                  25  


<210>  38
<211>  36
<212>  PRT
<213>  Aedes aegypti

<400>  38

Gly Gly Leu Lys Lys Leu Gly Lys Lys Leu Glu Gly Ala Gly Lys Arg 
1               5                   10                  15      


Val Phe Asn Ala Ala Glu Lys Ala Leu Pro Val Val Ala Gly Ala Lys 
            20                  25                  30          


Ala Leu Arg Lys 
        35      


<210>  39
<211>  40
<212>  PRT
<213>  Drosophila melanogaster

<400>  39

Gly Trp Leu Lys Lys Ile Gly Lys Lys Ile Glu Arg Val Gly Gln His 
1               5                   10                  15      


Thr Arg Asp Ala Thr Ile Gln Gly Leu Gly Ile Pro Gln Gln Ala Ala 
            20                  25                  30          


Asn Val Ala Ala Thr Ala Arg Gly 
        35                  40  


<210>  40
<211>  39
<212>  PRT
<213>  unknown

<220>
<223>  Sarcotoxin IA Fly

<400>  40

Gly Trp Leu Lys Lys Ile Gly Lys Lys Ile Glu Arg Val Gly Gln His 
1               5                   10                  15      


Thr Arg Asp Ala Thr Ile Gln Gly Leu Gly Ile Ala Gln Gln Ala Ala 
            20                  25                  30          


Asn Val Ala Ala Thr Ala Arg 
        35                  


<210>  41
<211>  17
<212>  PRT
<213>  Apis mellifera

<400>  41

Ala Asn Arg Pro Val Tyr Ile Pro Pro Pro Arg Pro Pro His Pro Arg 
1               5                   10                  15      


Leu 
    


<210>  42
<211>  24
<212>  PRT
<213>  unknown

<220>
<223>  Ascaphine 5 Frog

<400>  42

Gly Ile Lys Asp Trp Ile Lys Gly Ala Ala Lys Lys Leu Ile Lys Thr 
1               5                   10                  15      


Val Ala Ser His Ile Ala Asn Gln 
            20                  


<210>  43
<211>  22
<212>  PRT
<213>  unknown

<220>
<223>  Nigrocine 2 Frog

<400>  43

Gly Leu Leu Ser Lys Val Leu Gly Val Gly Lys Lys Val Leu Cys Gly 
1               5                   10                  15      


Val Ser Gly Leu Val Cys 
            20          


<210>  44
<211>  24
<212>  PRT
<213>  unknown

<220>
<223>  Pseudin 1 Rana Frog

<400>  44

Gly Leu Asn Thr Leu Lys Lys Val Phe Gln Gly Leu His Glu Ala Ile 
1               5                   10                  15      


Lys Leu Ile Asn Asn His Val Gln 
            20                  


<210>  45
<211>  18
<212>  PRT
<213>  unknown

<220>
<223>  Ranalexin Frog

<400>  45

Phe Leu Gly Gly Leu Ile Val Pro Ala Met Ile Cys Ala Val Thr Lys 
1               5                   10                  15      


Lys Cys 
        


<210>  46
<211>  26
<212>  PRT
<213>  unknown

<220>
<223>  Melittin bee

<400>  46

Gly Ile Gly Ala Val Leu Lys Val Leu Thr Thr Gly Leu Pro Ala Leu 
1               5                   10                  15      


Ile Ser Trp Ile Lys Arg Lys Arg Gln Gln 
            20                  25      


<210>  47
<211>  25
<212>  PRT
<213>  unknown

<220>
<223>  Lycotoxin 1 Spider

<400>  47

Ile Trp Leu Thr Ala Leu Lys Phe Leu Gly Lys His Ala Ala Lys Lys 
1               5                   10                  15      


Leu Ala Lys Gln Gln Leu Ser Lys Leu 
            20                  25  


<210>  48
<211>  19
<212>  PRT
<213>  unknown

<220>
<223>  Parasin 1 Fish

<400>  48

Lys Gly Arg Gly Lys Gln Gly Gly Lys Val Arg Ala Lys Ala Lys Thr 
1               5                   10                  15      


Arg Ser Ser 
            


<210>  49
<211>  39
<212>  PRT
<213>  unknown

<220>
<223>  Buforin I Toad

<400>  49

Ala Gly Arg Gly Lys Gln Gly Gly Lys Val Arg Ala Lys Ala Lys Thr 
1               5                   10                  15      


Arg Ser Ser Arg Ala Gly Leu Gln Phe Pro Val Gly Arg Val His Arg 
            20                  25                  30          


Leu Leu Arg Lys Gly Asn Tyr 
        35                  


<210>  50
<211>  34
<212>  PRT
<213>  unknown

<220>
<223>  Dermaseptin 1 Frog

<400>  50

Ala Leu Trp Lys Thr Met Leu Lys Lys Leu Gly Thr Met Ala Leu His 
1               5                   10                  15      


Ala Gly Lys Ala Ala Leu Gly Ala Ala Ala Asp Thr Ile Ser Gln Gly 
            20                  25                  30          


Thr Gln 
        


<210>  51
<211>  12
<212>  PRT
<213>  unknown

<220>
<223>  Bactenecin 1 Cow

<400>  51

Arg Leu Cys Arg Ile Val Val Ile Arg Val Cys Arg 
1               5                   10          


<210>  52
<211>  21
<212>  PRT
<213>  unknown

<220>
<223>  Thanatin Insect

<400>  52

Gly Ser Lys Lys Pro Val Pro Ile Ile Tyr Cys Asn Arg Arg Thr Gly 
1               5                   10                  15      


Lys Cys Gln Arg Met 
            20      


<210>  53
<211>  19
<212>  PRT
<213>  unknown

<220>
<223>  Brevinin 1T Rana frogs

<400>  53

Val Asn Pro Ile Ile Leu Gly Val Leu Pro Lys Val Cys Leu Ile Thr 
1               5                   10                  15      


Lys Lys Cys 
            


<210>  54
<211>  26
<212>  PRT
<213>  unknown

<220>
<223>  Ranateurin 1 Rana frog

<400>  54

Ser Met Leu Ser Val Leu Lys Asn Leu Gly Lys Val Gly Leu Gly Phe 
1               5                   10                  15      


Val Ala Cys Lys Ile Asn Ile Lys Gln Cys 
            20                  25      


<210>  55
<211>  46
<212>  PRT
<213>  unknown

<220>
<223>  Esculentin 1 Rana frogs

<400>  55

Gly Ile Phe Ser Lys Leu Gly Arg Lys Lys Ile Lys Asn Leu Leu Ile 
1               5                   10                  15      


Ser Gly Leu Lys Asn Val Gly Lys Glu Val Gly Met Asp Val Val Arg 
            20                  25                  30          


Thr Gly Ile Lys Ile Ala Gly Cys Lys Ile Lys Gly Glu Cys 
        35                  40                  45      


<210>  56
<211>  17
<212>  PRT
<213>  Limulus polyphemus

<400>  56

Arg Trp Cys Phe Arg Val Cys Tyr Arg Gly Ile Cys Tyr Arg Lys Cys 
1               5                   10                  15      


Arg 
    


<210>  57
<211>  25
<212>  PRT
<213>  unknown

<220>
<223>  Androctonin Scorpion

<400>  57

Arg Ser Val Cys Arg Gln Ile Lys Ile Cys Arg Arg Arg Gly Gly Cys 
1               5                   10                  15      


Tyr Tyr Lys Cys Thr Asn Arg Pro Tyr 
            20                  25  


<210>  58
<211>  30
<212>  PRT
<213>  Homo sapiens

<400>  58

Asp Cys Tyr Cys Arg Ile Pro Ala Cys Ile Ala Gly Glu Arg Arg Tyr 
1               5                   10                  15      


Gly Thr Cys Ile Tyr Gln Gly Arg Leu Trp Ala Phe Cys Cys 
            20                  25                  30  


<210>  59
<211>  38
<212>  PRT
<213>  unknown

<220>
<223>  beta-defensin cow

<400>  59

Asn Pro Val Ser Cys Val Arg Asn Lys Gly Ile Cys Val Pro Ile Arg 
1               5                   10                  15      


Cys Pro Gly Ser Met Lys Gln Ile Gly Thr Cys Val Gly Arg Ala Val 
            20                  25                  30          


Lys Cys Cys Arg Lys Lys 
        35              


<210>  60
<211>  18
<212>  PRT
<213>  unknown

<220>
<223>  theta-defensin monkey

<400>  60

Gly Phe Cys Arg Cys Leu Cys Arg Arg Gly Val Cys Arg Cys Ile Cys 
1               5                   10                  15      


Thr Arg 
        


<210>  61
<211>  40
<212>  PRT
<213>  unknown

<220>
<223>  defensin (sapecin A) insect

<400>  61

Ala Thr Cys Asp Leu Leu Ser Gly Thr Gly Ile Asn His Ser Ala Cys 
1               5                   10                  15      


Ala Ala His Cys Leu Leu Arg Gly Asn Arg Gly Gly Tyr Cys Asn Gly 
            20                  25                  30          


Lys Ala Val Cys Val Cys Arg Asn 
        35                  40  


<210>  62
<211>  46
<212>  PRT
<213>  unknown

<220>
<223>  Thionin (crambin) plant

<400>  62

Thr Thr Cys Cys Pro Ser Ile Val Ala Arg Ser Asn Phe Asn Val Cys 
1               5                   10                  15      


Arg Ile Pro Gly Thr Pro Glu Ala Ile Cys Ala Thr Tyr Thr Gly Cys 
            20                  25                  30          


Ile Ile Ile Pro Gly Ala Thr Cys Pro Gly Asp Tyr Ala Asn 
        35                  40                  45      


<210>  63
<211>  50
<212>  PRT
<213>  unknown

<220>
<223>  defensin from radish

<400>  63

Gln Lys Leu Cys Gln Arg Pro Ser Gly Thr Trp Ser Gly Val Cys Gly 
1               5                   10                  15      


Asn Asn Asn Ala Cys Lys Asn Gln Cys Ile Arg Leu Glu Lys Ala Arg 
            20                  25                  30          


His Gly Ser Cys Asn Tyr Val Phe Pro Ala His Cys Ile Cys Tyr Phe 
        35                  40                  45              


Pro Cys 
    50  


<210>  64
<211>  44
<212>  PRT
<213>  Drosophila melanogaster

<400>  64

Asp Cys Leu Ser Gly Arg Tyr Lys Gly Pro Cys Ala Val Trp Asp Asn 
1               5                   10                  15      


Glu Thr Cys Arg Arg Val Cys Lys Glu Glu Gly Arg Ser Ser Gly His 
            20                  25                  30          


Cys Ser Pro Ser Leu Lys Cys Trp Cys Glu Gly Cys 
        35                  40                  


<210>  65
<211>  25
<212>  PRT
<213>  Homo sapiens

<400>  65

Asp Thr His Phe Pro Ile Cys Ile Phe Cys Cys Gly Cys Cys His Arg 
1               5                   10                  15      


Ser Lys Cys Gly Met Cys Cys Lys Thr 
            20                  25  


<210>  66
<211>  44
<212>  PRT
<213>  unknown

<220>
<223>  Bac 5 Cow

<400>  66

Arg Phe Arg Pro Pro Ile Arg Arg Pro Pro Ile Arg Pro Pro Phe Tyr 
1               5                   10                  15      


Pro Pro Phe Arg Pro Pro Ile Arg Pro Pro Ile Phe Pro Pro Ile Arg 
            20                  25                  30          


Pro Pro Phe Arg Pro Pro Leu Gly Arg Pro Phe Pro 
        35                  40                  


<210>  67
<211>  39
<212>  PRT
<213>  unknown

<220>
<223>  PR-39 Pig

<400>  67

Arg Arg Arg Pro Arg Pro Pro Tyr Leu Pro Arg Pro Arg Pro Pro Pro 
1               5                   10                  15      


Phe Phe Pro Pro Arg Leu Pro Pro Arg Ile Pro Pro Gly Phe Pro Pro 
            20                  25                  30          


Arg Phe Pro Pro Arg Phe Pro 
        35                  


<210>  68
<211>  20
<212>  PRT
<213>  unknown

<220>
<223>  Pyrrhocoricin Insect

<400>  68

Val Asp Lys Gly Ser Tyr Leu Pro Arg Pro Thr Pro Pro Arg Pro Ile 
1               5                   10                  15      


Tyr Asn Arg Asn 
            20  


<210>  69
<211>  24
<212>  PRT
<213>  Homo sapiens

<400>  69

Asp Ser His Ala Lys Arg His His Gly Tyr Lys Arg Lys Phe His Glu 
1               5                   10                  15      


Lys His His Ser His Arg Gly Tyr 
            20                  


<210>  70
<211>  19
<212>  PRT
<213>  Unknown

<220>
<223>  ECP19

<400>  70

Arg Pro Pro Gln Phe Thr Arg Ala Gln Trp Phe Ala Ile Gln His Ile 
1               5                   10                  15      


Ser Leu Asn 
            


<210>  71
<211>  23
<212>  PRT
<213>  Unknown

<220>
<223>  MSI-594

<400>  71

Gly Ile Gly Lys Phe Leu Lys Lys Ala Lys Lys Gly Ile Gly Ala Val 
1               5                   10                  15      


Leu Lys Val Leu Thr Thr Gly 
            20              


<210>  72
<211>  35
<212>  PRT
<213>  Unknown

<220>
<223>  TL-ColM

<400>  72

Met Glu Thr Leu Thr Val His Ala Pro Ser Pro Ser Thr Asn Leu Pro 
1               5                   10                  15      


Ser Tyr Gly Asn Gly Ala Phe Ser Leu Ser Ala Pro His Val Pro Gly 
            20                  25                  30          


Ala Gly Pro 
        35  


<210>  73
<211>  18
<212>  PRT
<213>  Unknown

<220>
<223>  SBO

<400>  73

Lys Leu Lys Lys Ile Ala Gln Lys Ile Lys Asn Phe Phe Ala Lys Leu 
1               5                   10                  15      


Val Ala 
        


<210>  74
<211>  26
<212>  PRT
<213>  unknown

<220>
<223>  Macedocin

<400>  74

Gly Lys Asn Gly Val Phe Lys Thr Ile Ser His Glu Cys His Leu Asn 
1               5                   10                  15      


Thr Trp Ala Phe Leu Ala Thr Cys Cys Ser 
            20                  25      


<210>  75
<211>  22
<212>  PRT
<213>  unknown

<220>
<223>  Macedocin (Trunc)

<400>  75

Gly Lys Asn Gly Val Phe Lys Thr Ile Ser His Glu Cys His Leu Asn 
1               5                   10                  15      


Thr Trp Ala Phe Leu Ala 
            20          


<210>  76
<211>  28
<212>  PRT
<213>  unknown

<220>
<223>  D16

<400>  76

Ala Cys Lys Leu Lys Ser Leu Leu Lys Thr Leu Ser Lys Ala Lys Lys 
1               5                   10                  15      


Lys Lys Leu Lys Thr Leu Leu Lys Ala Leu Ser Lys 
            20                  25              


<210>  77
<211>  17
<212>  PRT
<213>  unknown

<220>
<223>  CPF-C1

<400>  77

Gly Phe Gly Ser Leu Leu Gly Lys Ala Leu Arg Leu Gly Ala Asn Val 
1               5                   10                  15      


Leu 
    


<210>  78
<211>  34
<212>  PRT
<213>  unknown

<220>
<223>  TL-ColM

<400>  78

Glu Thr Leu Thr Val His Ala Pro Ser Pro Ser Thr Asn Leu Pro Ser 
1               5                   10                  15      


Tyr Gly Asn Gly Ala Phe Ser Leu Ser Ala Pro His Val Pro Gly Ala 
            20                  25                  30          


Gly Pro 
        


<210>  79
<211>  26
<212>  PRT
<213>  unknown

<220>
<223>  TM-174E

<400>  79

Leu Ile Ser Lys Gly Trp Pro Tyr Leu Leu Val Val Val Leu Gly Ala 
1               5                   10                  15      


Thr Ile Tyr Phe Trp Gly Asn Ser Asn Gly 
            20                  25      


<210>  80
<211>  45
<212>  PRT
<213>  unknown

<220>
<223>  ECP45

<400>  80

Arg Pro Pro Gln Phe Thr Arg Ala Gln Trp Phe Ala Ile Gln His Ile 
1               5                   10                  15      


Ser Leu Asn Pro Pro Arg Cys Thr Ile Ala Met Arg Ala Ile Asn Asn 
            20                  25                  30          


Tyr Arg Trp Arg Cys Lys Asn Gln Asn Thr Phe Leu Arg 
        35                  40                  45  


<210>  81
<211>  50
<212>  PRT
<213>  unknown

<220>
<223>  ColicinE3_1-51 (S37F)

<400>  81

Ser Gly Gly Asp Gly Arg Gly His Asn Thr Gly Ala His Ser Thr Ser 
1               5                   10                  15      


Gly Asn Ile Asn Gly Gly Pro Thr Gly Leu Gly Val Gly Gly Gly Ala 
            20                  25                  30          


Ser Asp Gly Phe Gly Trp Ser Ser Glu Asn Asn Pro Trp Gly Gly Gly 
        35                  40                  45              


Ser Gly 
    50  


<210>  82
<211>  68
<212>  PRT
<213>  unknown

<220>
<223>  ColicinE3_1-69 (S37F)

<400>  82

Ser Gly Gly Asp Gly Arg Gly His Asn Thr Gly Ala His Ser Thr Ser 
1               5                   10                  15      


Gly Asn Ile Asn Gly Gly Pro Thr Gly Leu Gly Val Gly Gly Gly Ala 
            20                  25                  30          


Ser Asp Gly Phe Gly Trp Ser Ser Glu Asn Asn Pro Trp Gly Gly Gly 
        35                  40                  45              


Ser Gly Ser Gly Ile His Trp Gly Gly Gly Ser Gly His Gly Asn Gly 
    50                  55                  60                  


Gly Gly Asn Gly 
65              


<210>  83
<211>  52
<212>  PRT
<213>  unknown

<220>
<223>  ColicinD_1-53

<400>  83

Ser Asp Tyr Glu Gly Ser Gly Pro Thr Glu Gly Ile Asp Tyr Gly His 
1               5                   10                  15      


Ser Met Val Val Trp Pro Ser Thr Gly Leu Ile Ser Gly Gly Asp Val 
            20                  25                  30          


Lys Pro Gly Gly Ser Ser Gly Ile Ala Pro Ser Met Pro Pro Gly Trp 
        35                  40                  45              


Gly Asp Tyr Ser 
    50          


<210>  84
<211>  34
<212>  PRT
<213>  Limulus polyphemus

<400>  84

Gly Phe Lys Leu Lys Gly Met Ala Arg Ile Ser Cys Leu Pro Asn Gly 
1               5                   10                  15      


Gln Trp Ser Asn Phe Pro Pro Lys Cys Ile Arg Glu Cys Ala Met Val 
            20                  25                  30          


Ser Ser 
        


<210>  85
<211>  18
<212>  PRT
<213>  artificial

<220>
<223>  synthetic sequence

<400>  85

Gly Phe Phe Ile Pro Ala Val Ile Leu Pro Ser Ile Ala Phe Leu Ile 
1               5                   10                  15      


Val Pro 
        


<210>  86
<211>  5
<212>  PRT
<213>  artificial

<220>
<223>  synthetic sequence

<400>  86

Phe Phe Val Ala Pro 
1               5   


<210>  87
<211>  13
<212>  PRT
<213>  unknown

<220>
<223>  alpha4-helix of T4 lysozyme

<400>  87

Pro Asn Arg Ala Lys Arg Val Ile Thr Thr Phe Arg Thr 
1               5                   10              


<210>  88
<211>  27
<212>  PRT
<213>  artificial

<220>
<223>  synthetic sequence

<400>  88

Lys Arg Trp Val Lys Arg Val Lys Arg Val Lys Arg Trp Val Lys Arg 
1               5                   10                  15      


Val Val Arg Val Val Lys Arg Trp Val Lys Arg 
            20                  25          


<210>  89
<211>  25
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic sequence; MW2

<400>  89

Gly Lys Pro Gly Trp Leu Ile Lys Val Ala Leu Lys Phe Lys Lys Leu 
1               5                   10                  15      


Ile Arg Arg Pro Leu Lys Arg Leu Ala 
            20                  25  


<210>  90
<211>  5
<212>  PRT
<213>  Artificial

<220>
<223>  Linker sequence

<400>  90

Gly Gly Gly Gly Ser 
1               5   


<210>  91
<211>  6
<212>  PRT
<213>  artificial sequence

<220>
<223>  His-Tag (6x)

<400>  91

His His His His His His 
1               5       


<210>  92
<211>  336
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Enterococcal bacteriophae phi1 endolysin plus Buforin II, w/o 
       starting methionine

<400>  92

Thr Arg Ser Ser Arg Ala Gly Leu Gln Phe Pro Val Gly Arg Val His 
1               5                   10                  15      


Arg Leu Leu Arg Lys Gly Ser Ser Asn Ile Asn Met Glu Thr Ala Ile 
            20                  25                  30          


Ala Asn Met Tyr Ala Leu Lys Ala Arg Gly Ile Thr Tyr Ser Met Asn 
        35                  40                  45              


Tyr Ser Arg Thr Gly Ala Asp Gly Thr Gly Asp Cys Ser Gly Thr Val 
    50                  55                  60                  


Tyr Asp Ser Leu Arg Lys Ala Gly Ala Ser Asp Ala Gly Trp Val Leu 
65                  70                  75                  80  


Asn Thr Asp Ser Met His Ser Trp Leu Glu Lys Asn Gly Phe Lys Leu 
                85                  90                  95      


Ile Ala Gln Asn Lys Glu Trp Ser Ala Lys Arg Gly Asp Val Val Ile 
            100                 105                 110         


Phe Gly Lys Lys Gly Ala Ser Gly Gly Ser Ala Gly His Val Val Ile 
        115                 120                 125             


Phe Ile Ser Ser Thr Gln Ile Ile His Cys Thr Trp Lys Ser Ala Thr 
    130                 135                 140                 


Ala Asn Gly Val Tyr Val Asp Asn Glu Ala Thr Thr Cys Pro Tyr Ser 
145                 150                 155                 160 


Met Gly Trp Tyr Val Tyr Arg Leu Asn Gly Gly Ser Thr Pro Pro Lys 
                165                 170                 175     


Pro Asn Thr Lys Lys Val Lys Val Leu Lys His Ala Thr Asn Trp Ser 
            180                 185                 190         


Pro Ser Ser Lys Gly Ala Lys Met Ala Ser Phe Val Lys Gly Gly Thr 
        195                 200                 205             


Phe Glu Val Lys Gln Gln Arg Pro Ile Ser Tyr Ser Tyr Ser Asn Gln 
    210                 215                 220                 


Glu Tyr Leu Ile Val Asn Lys Gly Thr Val Leu Gly Trp Val Leu Ser 
225                 230                 235                 240 


Gln Asp Ile Glu Gly Gly Tyr Gly Ser Asp Arg Val Gly Gly Ser Lys 
                245                 250                 255     


Pro Lys Leu Pro Ala Gly Phe Thr Lys Glu Glu Ala Thr Phe Ile Asn 
            260                 265                 270         


Gly Asn Ala Pro Ile Thr Thr Arg Lys Asn Lys Pro Ser Leu Ser Ser 
        275                 280                 285             


Gln Thr Ala Thr Pro Leu Tyr Pro Gly Gln Ser Val Arg Tyr Leu Gly 
    290                 295                 300                 


Trp Lys Ser Ala Glu Gly Tyr Ile Trp Ile Tyr Ala Thr Asp Gly Arg 
305                 310                 315                 320 


Tyr Ile Pro Val Arg Pro Val Gly Lys Glu Ala Trp Gly Thr Phe Lys 
                325                 330                 335     


<210>  93
<211>  337
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Enterococcal bacteriophae phi1 endolysin plus Buforin II

<400>  93

Met Thr Arg Ser Ser Arg Ala Gly Leu Gln Phe Pro Val Gly Arg Val 
1               5                   10                  15      


His Arg Leu Leu Arg Lys Gly Ser Ser Asn Ile Asn Met Glu Thr Ala 
            20                  25                  30          


Ile Ala Asn Met Tyr Ala Leu Lys Ala Arg Gly Ile Thr Tyr Ser Met 
        35                  40                  45              


Asn Tyr Ser Arg Thr Gly Ala Asp Gly Thr Gly Asp Cys Ser Gly Thr 
    50                  55                  60                  


Val Tyr Asp Ser Leu Arg Lys Ala Gly Ala Ser Asp Ala Gly Trp Val 
65                  70                  75                  80  


Leu Asn Thr Asp Ser Met His Ser Trp Leu Glu Lys Asn Gly Phe Lys 
                85                  90                  95      


Leu Ile Ala Gln Asn Lys Glu Trp Ser Ala Lys Arg Gly Asp Val Val 
            100                 105                 110         


Ile Phe Gly Lys Lys Gly Ala Ser Gly Gly Ser Ala Gly His Val Val 
        115                 120                 125             


Ile Phe Ile Ser Ser Thr Gln Ile Ile His Cys Thr Trp Lys Ser Ala 
    130                 135                 140                 


Thr Ala Asn Gly Val Tyr Val Asp Asn Glu Ala Thr Thr Cys Pro Tyr 
145                 150                 155                 160 


Ser Met Gly Trp Tyr Val Tyr Arg Leu Asn Gly Gly Ser Thr Pro Pro 
                165                 170                 175     


Lys Pro Asn Thr Lys Lys Val Lys Val Leu Lys His Ala Thr Asn Trp 
            180                 185                 190         


Ser Pro Ser Ser Lys Gly Ala Lys Met Ala Ser Phe Val Lys Gly Gly 
        195                 200                 205             


Thr Phe Glu Val Lys Gln Gln Arg Pro Ile Ser Tyr Ser Tyr Ser Asn 
    210                 215                 220                 


Gln Glu Tyr Leu Ile Val Asn Lys Gly Thr Val Leu Gly Trp Val Leu 
225                 230                 235                 240 


Ser Gln Asp Ile Glu Gly Gly Tyr Gly Ser Asp Arg Val Gly Gly Ser 
                245                 250                 255     


Lys Pro Lys Leu Pro Ala Gly Phe Thr Lys Glu Glu Ala Thr Phe Ile 
            260                 265                 270         


Asn Gly Asn Ala Pro Ile Thr Thr Arg Lys Asn Lys Pro Ser Leu Ser 
        275                 280                 285             


Ser Gln Thr Ala Thr Pro Leu Tyr Pro Gly Gln Ser Val Arg Tyr Leu 
    290                 295                 300                 


Gly Trp Lys Ser Ala Glu Gly Tyr Ile Trp Ile Tyr Ala Thr Asp Gly 
305                 310                 315                 320 


Arg Tyr Ile Pro Val Arg Pro Val Gly Lys Glu Ala Trp Gly Thr Phe 
                325                 330                 335     


Lys 
    


<210>  94
<211>  345
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Enterococcal bacteriophae phi1 endolysin plus Buforin II and 
       HisTag

<400>  94

Met Thr Arg Ser Ser Arg Ala Gly Leu Gln Phe Pro Val Gly Arg Val 
1               5                   10                  15      


His Arg Leu Leu Arg Lys Gly Ser Ser Asn Ile Asn Met Glu Thr Ala 
            20                  25                  30          


Ile Ala Asn Met Tyr Ala Leu Lys Ala Arg Gly Ile Thr Tyr Ser Met 
        35                  40                  45              


Asn Tyr Ser Arg Thr Gly Ala Asp Gly Thr Gly Asp Cys Ser Gly Thr 
    50                  55                  60                  


Val Tyr Asp Ser Leu Arg Lys Ala Gly Ala Ser Asp Ala Gly Trp Val 
65                  70                  75                  80  


Leu Asn Thr Asp Ser Met His Ser Trp Leu Glu Lys Asn Gly Phe Lys 
                85                  90                  95      


Leu Ile Ala Gln Asn Lys Glu Trp Ser Ala Lys Arg Gly Asp Val Val 
            100                 105                 110         


Ile Phe Gly Lys Lys Gly Ala Ser Gly Gly Ser Ala Gly His Val Val 
        115                 120                 125             


Ile Phe Ile Ser Ser Thr Gln Ile Ile His Cys Thr Trp Lys Ser Ala 
    130                 135                 140                 


Thr Ala Asn Gly Val Tyr Val Asp Asn Glu Ala Thr Thr Cys Pro Tyr 
145                 150                 155                 160 


Ser Met Gly Trp Tyr Val Tyr Arg Leu Asn Gly Gly Ser Thr Pro Pro 
                165                 170                 175     


Lys Pro Asn Thr Lys Lys Val Lys Val Leu Lys His Ala Thr Asn Trp 
            180                 185                 190         


Ser Pro Ser Ser Lys Gly Ala Lys Met Ala Ser Phe Val Lys Gly Gly 
        195                 200                 205             


Thr Phe Glu Val Lys Gln Gln Arg Pro Ile Ser Tyr Ser Tyr Ser Asn 
    210                 215                 220                 


Gln Glu Tyr Leu Ile Val Asn Lys Gly Thr Val Leu Gly Trp Val Leu 
225                 230                 235                 240 


Ser Gln Asp Ile Glu Gly Gly Tyr Gly Ser Asp Arg Val Gly Gly Ser 
                245                 250                 255     


Lys Pro Lys Leu Pro Ala Gly Phe Thr Lys Glu Glu Ala Thr Phe Ile 
            260                 265                 270         


Asn Gly Asn Ala Pro Ile Thr Thr Arg Lys Asn Lys Pro Ser Leu Ser 
        275                 280                 285             


Ser Gln Thr Ala Thr Pro Leu Tyr Pro Gly Gln Ser Val Arg Tyr Leu 
    290                 295                 300                 


Gly Trp Lys Ser Ala Glu Gly Tyr Ile Trp Ile Tyr Ala Thr Asp Gly 
305                 310                 315                 320 


Arg Tyr Ile Pro Val Arg Pro Val Gly Lys Glu Ala Trp Gly Thr Phe 
                325                 330                 335     


Lys Leu Glu His His His His His His 
            340                 345 


<210>  95
<211>  450
<212>  DNA
<213>  Artificial sequence

<220>
<223>  encoding SEQ ID NO2

<400>  95
atcaatatgg aaaccgccat tgcaaatatg tatgcactga aagcacgtgg cattacctat       60

agcatgaatt atagccgtac cggtgcagat ggcaccggtg attgtagcgg caccgtttat      120

gatagcctgc gtaaagccgg tgcaagtgat gcaggttggg ttctgaatac cgatagcatg      180

catagctggc tggaaaaaaa tggctttaaa ctgattgccc agaacaaaga atggtcagca      240

aaacgtggtg atgtggtgat ttttggtaaa aaaggtgcaa gcggtggtag cgcaggtcat      300

gttgttatct ttattagcag cacccagatt attcactgta cctggaaaag cgcaaccgca      360

aatggtgttt atgttgataa tgaagcaacc acctgtccgt atagcatggg ttggtatgtt      420

tatcgtctga atggtggtag cacccctccg                                       450


<210>  96
<211>  195
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Encoding SEQ ID NO:3

<400>  96
gaggccacct ttattaacgg caatgcaccg attaccaccc gtaaaaacaa accgagcctg       60

agcagccaga ccgcaacacc gctgtatccg ggtcagagcg ttcgttatct gggctggaaa      120

tcagcagaag gttatatttg gatttatgcc accgatggtc gttatattcc ggttcgtccg      180

gttggtaaag aagca                                                       195


<210>  97
<211>  939
<212>  DNA
<213>  Artificial sequence

<220>
<223>  encoding enterococcal phage phi1 endolysin w/o initial methionine

<400>  97
agcaacatca atatggaaac cgccattgca aatatgtatg cactgaaagc acgtggcatt       60

acctatagca tgaattatag ccgtaccggt gcagatggca ccggtgattg tagcggcacc      120

gtttatgata gcctgcgtaa agccggtgca agtgatgcag gttgggttct gaataccgat      180

agcatgcata gctggctgga aaaaaatggc tttaaactga ttgcccagaa caaagaatgg      240

tcagcaaaac gtggtgatgt ggtgattttt ggtaaaaaag gtgcaagcgg tggtagcgca      300

ggtcatgttg ttatctttat tagcagcacc cagattattc actgtacctg gaaaagcgca      360

accgcaaatg gtgtttatgt tgataatgaa gcaaccacct gtccgtatag catgggttgg      420

tatgtttatc gtctgaatgg tggtagcacc cctccgaaac cgaataccaa aaaagttaaa      480

gttctgaaac acgccaccaa ttggagcccg agcagcaaag gtgccaaaat ggcaagcttt      540

gttaaaggtg gtacgtttga agttaaacag cagcgtccga ttagctacag ctatagcaat      600

caagaatatc tgatcgtgaa taaaggcacc gttctgggtt gggtgctgag ccaggatatt      660

gaaggtggtt atggtagcga tcgtgttggt ggtagtaaac cgaaactgcc tgcaggtttt      720

acaaaagaag aggccacctt tattaacggc aatgcaccga ttaccacccg taaaaacaaa      780

ccgagcctga gcagccagac cgcaacaccg ctgtatccgg gtcagagcgt tcgttatctg      840

ggctggaaat cagcagaagg ttatatttgg atttatgcca ccgatggtcg ttatattccg      900

gttcgtccgg ttggtaaaga agcatggggc acctttaaa                             939


<210>  98
<211>  63
<212>  DNA
<213>  Artificial sequence

<220>
<223>  encoding Buforin II vertebrate

<400>  98
acccgtagct ctcgtgctgg cctgcagttt ccggttggtc gcgtgcaccg tctgctccgc       60

aaa                                                                     63


<210>  99
<211>  1011
<212>  DNA
<213>  artificial sequence

<220>
<223>  Encoding enterococcal bacteriophae phi1 endolysin plus Buforin II

<400>  99
atgacccgta gctctcgtgc tggcctgcag tttccggttg gtcgcgtgca ccgtctgctc       60

cgcaaaggat ccagcaacat caatatggaa accgccattg caaatatgta tgcactgaaa      120

gcacgtggca ttacctatag catgaattat agccgtaccg gtgcagatgg caccggtgat      180

tgtagcggca ccgtttatga tagcctgcgt aaagccggtg caagtgatgc aggttgggtt      240

ctgaataccg atagcatgca tagctggctg gaaaaaaatg gctttaaact gattgcccag      300

aacaaagaat ggtcagcaaa acgtggtgat gtggtgattt ttggtaaaaa aggtgcaagc      360

ggtggtagcg caggtcatgt tgttatcttt attagcagca cccagattat tcactgtacc      420

tggaaaagcg caaccgcaaa tggtgtttat gttgataatg aagcaaccac ctgtccgtat      480

agcatgggtt ggtatgttta tcgtctgaat ggtggtagca cccctccgaa accgaatacc      540

aaaaaagtta aagttctgaa acacgccacc aattggagcc cgagcagcaa aggtgccaaa      600

atggcaagct ttgttaaagg tggtacgttt gaagttaaac agcagcgtcc gattagctac      660

agctatagca atcaagaata tctgatcgtg aataaaggca ccgttctggg ttgggtgctg      720

agccaggata ttgaaggtgg ttatggtagc gatcgtgttg gtggtagtaa accgaaactg      780

cctgcaggtt ttacaaaaga agaggccacc tttattaacg gcaatgcacc gattaccacc      840

cgtaaaaaca aaccgagcct gagcagccag accgcaacac cgctgtatcc gggtcagagc      900

gttcgttatc tgggctggaa atcagcagaa ggttatattt ggatttatgc caccgatggt      960

cgttatattc cggttcgtcc ggttggtaaa gaagcatggg gcacctttaa a              1011


<210>  100
<211>  7
<212>  PRT
<213>  Homo sapiens

<400>  100

His Pro Gln Tyr Asn Gln Arg 
1               5           


<210>  101
<211>  322
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Enterococcal bacteriophae phi1 endolysin plus peptide, w/o 
       starting methionine

<400>  101

Ser Asn Ile Asn Met Glu Thr Ala Ile Ala Asn Met Tyr Ala Leu Lys 
1               5                   10                  15      


Ala Arg Gly Ile Thr Tyr Ser Met Asn Tyr Ser Arg Thr Gly Ala Asp 
            20                  25                  30          


Gly Thr Gly Asp Cys Ser Gly Thr Val Tyr Asp Ser Leu Arg Lys Ala 
        35                  40                  45              


Gly Ala Ser Asp Ala Gly Trp Val Leu Asn Thr Asp Ser Met His Ser 
    50                  55                  60                  


Trp Leu Glu Lys Asn Gly Phe Lys Leu Ile Ala Gln Asn Lys Glu Trp 
65                  70                  75                  80  


Ser Ala Lys Arg Gly Asp Val Val Ile Phe Gly Lys Lys Gly Ala Ser 
                85                  90                  95      


Gly Gly Ser Ala Gly His Val Val Ile Phe Ile Ser Ser Thr Gln Ile 
            100                 105                 110         


Ile His Cys Thr Trp Lys Ser Ala Thr Ala Asn Gly Val Tyr Val Asp 
        115                 120                 125             


Asn Glu Ala Thr Thr Cys Pro Tyr Ser Met Gly Trp Tyr Val Tyr Arg 
    130                 135                 140                 


Leu Asn Gly Gly Ser Thr Pro Pro Lys Pro Asn Thr Lys Lys Val Lys 
145                 150                 155                 160 


Val Leu Lys His Ala Thr Asn Trp Ser Pro Ser Ser Lys Gly Ala Lys 
                165                 170                 175     


Met Ala Ser Phe Val Lys Gly Gly Thr Phe Glu Val Lys Gln Gln Arg 
            180                 185                 190         


Pro Ile Ser Tyr Ser Tyr Ser Asn Gln Glu Tyr Leu Ile Val Asn Lys 
        195                 200                 205             


Gly Thr Val Leu Gly Trp Val Leu Ser Gln Asp Ile Glu Gly Gly Tyr 
    210                 215                 220                 


Gly Ser Asp Arg Val Gly Gly Ser Lys Pro Lys Leu Pro Ala Gly Phe 
225                 230                 235                 240 


Thr Lys Glu Glu Ala Thr Phe Ile Asn Gly Asn Ala Pro Ile Thr Thr 
                245                 250                 255     


Arg Lys Asn Lys Pro Ser Leu Ser Ser Gln Thr Ala Thr Pro Leu Tyr 
            260                 265                 270         


Pro Gly Gln Ser Val Arg Tyr Leu Gly Trp Lys Ser Ala Glu Gly Tyr 
        275                 280                 285             


Ile Trp Ile Tyr Ala Thr Asp Gly Arg Tyr Ile Pro Val Arg Pro Val 
    290                 295                 300                 


Gly Lys Glu Ala Trp Gly Thr Phe Lys Gly Ser His Pro Gln Tyr Asn 
305                 310                 315                 320 


Gln Arg 
        


<210>  102
<211>  323
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Enterococcal bacteriophae phi1 endolysin plus peptide

<400>  102

Met Ser Asn Ile Asn Met Glu Thr Ala Ile Ala Asn Met Tyr Ala Leu 
1               5                   10                  15      


Lys Ala Arg Gly Ile Thr Tyr Ser Met Asn Tyr Ser Arg Thr Gly Ala 
            20                  25                  30          


Asp Gly Thr Gly Asp Cys Ser Gly Thr Val Tyr Asp Ser Leu Arg Lys 
        35                  40                  45              


Ala Gly Ala Ser Asp Ala Gly Trp Val Leu Asn Thr Asp Ser Met His 
    50                  55                  60                  


Ser Trp Leu Glu Lys Asn Gly Phe Lys Leu Ile Ala Gln Asn Lys Glu 
65                  70                  75                  80  


Trp Ser Ala Lys Arg Gly Asp Val Val Ile Phe Gly Lys Lys Gly Ala 
                85                  90                  95      


Ser Gly Gly Ser Ala Gly His Val Val Ile Phe Ile Ser Ser Thr Gln 
            100                 105                 110         


Ile Ile His Cys Thr Trp Lys Ser Ala Thr Ala Asn Gly Val Tyr Val 
        115                 120                 125             


Asp Asn Glu Ala Thr Thr Cys Pro Tyr Ser Met Gly Trp Tyr Val Tyr 
    130                 135                 140                 


Arg Leu Asn Gly Gly Ser Thr Pro Pro Lys Pro Asn Thr Lys Lys Val 
145                 150                 155                 160 


Lys Val Leu Lys His Ala Thr Asn Trp Ser Pro Ser Ser Lys Gly Ala 
                165                 170                 175     


Lys Met Ala Ser Phe Val Lys Gly Gly Thr Phe Glu Val Lys Gln Gln 
            180                 185                 190         


Arg Pro Ile Ser Tyr Ser Tyr Ser Asn Gln Glu Tyr Leu Ile Val Asn 
        195                 200                 205             


Lys Gly Thr Val Leu Gly Trp Val Leu Ser Gln Asp Ile Glu Gly Gly 
    210                 215                 220                 


Tyr Gly Ser Asp Arg Val Gly Gly Ser Lys Pro Lys Leu Pro Ala Gly 
225                 230                 235                 240 


Phe Thr Lys Glu Glu Ala Thr Phe Ile Asn Gly Asn Ala Pro Ile Thr 
                245                 250                 255     


Thr Arg Lys Asn Lys Pro Ser Leu Ser Ser Gln Thr Ala Thr Pro Leu 
            260                 265                 270         


Tyr Pro Gly Gln Ser Val Arg Tyr Leu Gly Trp Lys Ser Ala Glu Gly 
        275                 280                 285             


Tyr Ile Trp Ile Tyr Ala Thr Asp Gly Arg Tyr Ile Pro Val Arg Pro 
    290                 295                 300                 


Val Gly Lys Glu Ala Trp Gly Thr Phe Lys Gly Ser His Pro Gln Tyr 
305                 310                 315                 320 


Asn Gln Arg 
            


<210>  103
<211>  329
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Enterococcal bacteriophae phi1 endolysin plus HisTag and peptide

<400>  103

Met Ser Asn Ile Asn Met Glu Thr Ala Ile Ala Asn Met Tyr Ala Leu 
1               5                   10                  15      


Lys Ala Arg Gly Ile Thr Tyr Ser Met Asn Tyr Ser Arg Thr Gly Ala 
            20                  25                  30          


Asp Gly Thr Gly Asp Cys Ser Gly Thr Val Tyr Asp Ser Leu Arg Lys 
        35                  40                  45              


Ala Gly Ala Ser Asp Ala Gly Trp Val Leu Asn Thr Asp Ser Met His 
    50                  55                  60                  


Ser Trp Leu Glu Lys Asn Gly Phe Lys Leu Ile Ala Gln Asn Lys Glu 
65                  70                  75                  80  


Trp Ser Ala Lys Arg Gly Asp Val Val Ile Phe Gly Lys Lys Gly Ala 
                85                  90                  95      


Ser Gly Gly Ser Ala Gly His Val Val Ile Phe Ile Ser Ser Thr Gln 
            100                 105                 110         


Ile Ile His Cys Thr Trp Lys Ser Ala Thr Ala Asn Gly Val Tyr Val 
        115                 120                 125             


Asp Asn Glu Ala Thr Thr Cys Pro Tyr Ser Met Gly Trp Tyr Val Tyr 
    130                 135                 140                 


Arg Leu Asn Gly Gly Ser Thr Pro Pro Lys Pro Asn Thr Lys Lys Val 
145                 150                 155                 160 


Lys Val Leu Lys His Ala Thr Asn Trp Ser Pro Ser Ser Lys Gly Ala 
                165                 170                 175     


Lys Met Ala Ser Phe Val Lys Gly Gly Thr Phe Glu Val Lys Gln Gln 
            180                 185                 190         


Arg Pro Ile Ser Tyr Ser Tyr Ser Asn Gln Glu Tyr Leu Ile Val Asn 
        195                 200                 205             


Lys Gly Thr Val Leu Gly Trp Val Leu Ser Gln Asp Ile Glu Gly Gly 
    210                 215                 220                 


Tyr Gly Ser Asp Arg Val Gly Gly Ser Lys Pro Lys Leu Pro Ala Gly 
225                 230                 235                 240 


Phe Thr Lys Glu Glu Ala Thr Phe Ile Asn Gly Asn Ala Pro Ile Thr 
                245                 250                 255     


Thr Arg Lys Asn Lys Pro Ser Leu Ser Ser Gln Thr Ala Thr Pro Leu 
            260                 265                 270         


Tyr Pro Gly Gln Ser Val Arg Tyr Leu Gly Trp Lys Ser Ala Glu Gly 
        275                 280                 285             


Tyr Ile Trp Ile Tyr Ala Thr Asp Gly Arg Tyr Ile Pro Val Arg Pro 
    290                 295                 300                 


Val Gly Lys Glu Ala Trp Gly Thr Phe Lys Gly Ser His His His His 
305                 310                 315                 320 


His His His Pro Gln Tyr Asn Gln Arg 
                325                 


<210>  104
<211>  241
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  aa 2-242 of Streptococcus suis enzyme (WP_029171101.1); C136S

<400>  104

Gly Val Asn Ile Glu Thr Ala Leu Arg Trp Met Ser Asp Arg Lys Gly 
1               5                   10                  15      


Arg Val Thr Tyr Ser Met Asp Tyr Arg Asn Gly Pro Asn Ser Phe Asp 
            20                  25                  30          


Cys Ser Ser Ser Val Tyr Tyr Ala Leu Met Ser Ala Gly Ala Ile Ser 
        35                  40                  45              


Ala Gly Trp Ala Val Asn Thr Glu Tyr Glu His Asp Trp Leu Leu Lys 
    50                  55                  60                  


Asn Gly Tyr Lys Leu Ile Ala Glu Asn Thr Asp Trp Asp Ala Lys Arg 
65                  70                  75                  80  


Gly Asp Ile Phe Ile Trp Gly Arg Arg Gly Gln Ser Ala Gly Ala Gly 
                85                  90                  95      


Gly His Thr Gly Ile Phe Ile Asp Pro Asp Asn Ile Ile His Cys Asn 
            100                 105                 110         


Tyr Ala Arg Asn Ser Ile Thr Val Asp Asn Tyr Asn Gln Thr Ala Ala 
        115                 120                 125             


Ala Ser Gly Trp Met Tyr Ser Tyr Val Tyr Arg Leu Ala Asn Gln Thr 
    130                 135                 140                 


Ser Thr Ala Gly Lys Ser Leu Glu Thr Leu Val Gln Glu Thr Leu Ala 
145                 150                 155                 160 


Gly Lys Tyr Gly Asn Gly Asp Gln Arg Lys Ala Ala Leu Gly Asn Gln 
                165                 170                 175     


Tyr Glu Ala Val Met Ala Val Ile Asn Gly Lys Ala Thr Ala Pro Lys 
            180                 185                 190         


Lys Thr Val Asp Gln Leu Ala Gln Glu Val Ile Ala Gly Lys His Gly 
        195                 200                 205             


Asn Gly Glu Ala Arg Lys Gln Ser Leu Gly Ala Asp Tyr Pro Ala Val 
    210                 215                 220                 


Gln Lys Arg Val Thr Glu Leu Leu Lys Lys Gln Pro Ser Glu Pro Ser 
225                 230                 235                 240 


Lys 
    


<210>  105
<211>  346
<212>  PRT
<213>  Artificial sequence

<220>
<223>  aa 2-242 of Streptococcus suis enzyme (WP_029171101.1); C136S, 
       plus enterococcal bacteriophae phi1 endolysin CBD plus HisTag and
       peptide

<400>  105

Met Gly Val Asn Ile Glu Thr Ala Leu Arg Trp Met Ser Asp Arg Lys 
1               5                   10                  15      


Gly Arg Val Thr Tyr Ser Met Asp Tyr Arg Asn Gly Pro Asn Ser Phe 
            20                  25                  30          


Asp Cys Ser Ser Ser Val Tyr Tyr Ala Leu Met Ser Ala Gly Ala Ile 
        35                  40                  45              


Ser Ala Gly Trp Ala Val Asn Thr Glu Tyr Glu His Asp Trp Leu Leu 
    50                  55                  60                  


Lys Asn Gly Tyr Lys Leu Ile Ala Glu Asn Thr Asp Trp Asp Ala Lys 
65                  70                  75                  80  


Arg Gly Asp Ile Phe Ile Trp Gly Arg Arg Gly Gln Ser Ala Gly Ala 
                85                  90                  95      


Gly Gly His Thr Gly Ile Phe Ile Asp Pro Asp Asn Ile Ile His Cys 
            100                 105                 110         


Asn Tyr Ala Arg Asn Ser Ile Thr Val Asp Asn Tyr Asn Gln Thr Ala 
        115                 120                 125             


Ala Ala Ser Gly Trp Met Tyr Ser Tyr Val Tyr Arg Leu Ala Asn Gln 
    130                 135                 140                 


Thr Ser Thr Ala Gly Lys Ser Leu Glu Thr Leu Val Gln Glu Thr Leu 
145                 150                 155                 160 


Ala Gly Lys Tyr Gly Asn Gly Asp Gln Arg Lys Ala Ala Leu Gly Asn 
                165                 170                 175     


Gln Tyr Glu Ala Val Met Ala Val Ile Asn Gly Lys Ala Thr Ala Pro 
            180                 185                 190         


Lys Lys Thr Val Asp Gln Leu Ala Gln Glu Val Ile Ala Gly Lys His 
        195                 200                 205             


Gly Asn Gly Glu Ala Arg Lys Gln Ser Leu Gly Ala Asp Tyr Pro Ala 
    210                 215                 220                 


Val Gln Lys Arg Val Thr Glu Leu Leu Lys Lys Gln Pro Ser Glu Pro 
225                 230                 235                 240 


Ser Lys Gly Ser Asp Arg Val Gly Gly Ser Lys Pro Lys Leu Pro Ala 
                245                 250                 255     


Gly Phe Thr Lys Glu Glu Ala Thr Phe Ile Asn Gly Asn Ala Pro Ile 
            260                 265                 270         


Thr Thr Arg Lys Asn Lys Pro Ser Leu Ser Ser Gln Thr Ala Thr Pro 
        275                 280                 285             


Leu Tyr Pro Gly Gln Ser Val Arg Tyr Leu Gly Trp Lys Ser Ala Glu 
    290                 295                 300                 


Gly Tyr Ile Trp Ile Tyr Ala Thr Asp Gly Arg Tyr Ile Pro Val Arg 
305                 310                 315                 320 


Pro Val Gly Lys Glu Ala Trp Gly Thr Phe Lys Gly Ser His His His 
                325                 330                 335     


His His His His Pro Gln Tyr Asn Gln Arg 
            340                 345     


