SEQUENCE LISTING

<110> Cellectis


<120> TARGETED GENE INSERTION FOR IMPROVED IMMUNE CELLS THERAPY

<130> P81604915PCT00 

<150> US62/410,187
<151> 2016-10-19

<150> PA201670840
<151> 2016-10-27

<160> 67

<170> PatentIn version 3.5

<210>  1

<211>  1000
<212>  DNA
<213>  artificial sequence

<220>  
<223>  PD1 left homology

<400>  1
ccaagccctg accctggcag gcatatgttt caggaggtcc ttgtcttggg agcccagggt     60
cgggggcccc gtgtctgtcc acatccgagt caatggccca tctcgtctct gaagcatctt    120
tgctgtgagc tctagtcccc actgtcttgc tggaaaatgt ggaggcccca ctgcccactg    180
cccagggcag caatgcccat accacgtggt cccagctccg agcttgtcct gaaaaggggg    240
caaagactgg accctgagcc tgccaagggg ccacactcct cccagggctg gggtctccat    300
gggcagcccc ccacccaccc agaccagtta cactcccctg tgccagagca gtgcagacag    360
gaccaggcca ggatgcccaa gggtcagggg ctggggatgg gtagccccca aacagccctt    420
tctgggggaa ctggcctcaa cggggaaggg ggtgaaggct cttagtagga aatcagggag    480
acccaagtca gagccaggtg ctgtgcagaa gctgcagcct cacgtagaag gaagaggctc    540
tgcagtggag gccagtgccc atccccgggt ggcagaggcc ccagcagaga cttctcaatg    600
acattccagc tggggtggcc cttccagagc ccttgctgcc cgagggatgt gagcaggtgg    660
ccggggaggc tttgtggggc cacccagccc cttcctcacc tctctccatc tctcagactc    720
cccagacagg ccctggaacc cccccacctt ctccccagcc ctgctcgtgg tgaccgaagg    780
ggacaacgcc accttcacct gcagcttctc caacacatcg gagagcttcg tgctaaactg    840
gtaccgcatg agccccagca accagacgga caagctggcc gccttccccg aggaccgcag    900
ccagcccggc caggactgcc gcttccgtgt cacacaactg cccaacgggc gtgacttcca    960
catgagcgtg gtcagggccc ggcgcaatga cagcggcacc                         1000


<210>  2

<211>  1000
<212>  DNA
<213>  artificial sequence

<220>  
<223>  PD1 right homology

<400>  2
gcctgcgggc agagctcagg gtgacaggtg cggcctcgga ggccccgggg caggggtgag     60
ctgagccggt cctggggtgg gtgtcccctc ctgcacagga tcaggagctc cagggtcgta    120
gggcagggac cccccagctc cagtccaggg ctctgtcctg cacctgggga atggtgaccg    180
gcatctctgt cctctagctc tggaagcacc ccagcccctc tagtctgccc tcacccctga    240
ccctgaccct ccaccctgac cccgtcctaa cccctgacct ttgtgccctt ccagagagaa    300
gggcagaagt gcccacagcc caccccagcc cctcacccag gccagccggc cagttccaaa    360
ccctggtggt tggtgtcgtg ggcggcctgc tgggcagcct ggtgctgcta gtctgggtcc    420
tggccgtcat ctgctcccgg gccgcacgag gtaacgtcat cccagcccct cggcctgccc    480
tgccctaacc ctgctggcgg ccctcactcc cgcctcccct tcctccaccc ttccctcacc    540
ccaccccacc tccccccatc tccccgccag gctaagtccc tgatgaaggc ccctggacta    600
agacccccca cctaggagca cggctcaggg tcggcctggt gaccccaagt gtgtttctct    660
gcagggacaa taggagccag gcgcaccggc cagcccctgg tgagtctcac tcttttcctg    720
catgatccac tgtgccttcc ttcctgggtg ggcagaggtg gaaggacagg ctgggaccac    780
acggcctgca ggactcacat tctattatag ccaggacccc acctccccag cccccaggca    840
gcaacctcaa tccctaaagc catgatctgg ggccccagcc cacctgcggt ctccgggggt    900
gcccggccca tgtgtgtgcc tgcctgcggt ctccaggggt gcctggccca cgcgtgtgcc    960
cgcctgcggt ctctgggggt gcccggccca catatgtgcc                         1000


<210>  3

<211>  2781
<212>  DNA
<213>  artificial sequence

<220>  
<223>  PD1_T3C-L2

<400>  3
atgggcgatc ctaaaaagaa acgtaaggtc atcgatatcg ccgatctacg cacgctcggc     60
tacagccagc agcaacagga gaagatcaaa ccgaaggttc gttcgacagt ggcgcagcac    120
cacgaggcac tggtcggcca cgggtttaca cacgcgcaca tcgttgcgtt aagccaacac    180
ccggcagcgt tagggaccgt cgctgtcaag tatcaggaca tgatcgcagc gttgccagag    240
gcgacacacg aagcgatcgt tggcgtcggc aaacagtggt ccggcgcacg cgctctggag    300
gccttgctca cggtggcggg agagttgaga ggtccaccgt tacagttgga cacaggccaa    360
cttctcaaga ttgcaaaacg tggcggcgtg accgcagtgg aggcagtgca tgcatggcgc    420
aatgcactga cgggtgcccc gctcaacttg acccccgagc aagtggtggc tatcgcttcc    480
aagctggggg gaaagcaggc cctggagacc gtccaggccc ttctcccagt gctttgccag    540
gctcacggac tgacccctga acaggtggtg gcaattgcct cacacgacgg gggcaagcag    600
gcactggaga ctgtccagcg gctgctgcct gtcctctgcc aggcccacgg actcactcct    660
gagcaggtcg tggccattgc cagccacgat gggggcaaac aggctctgga gaccgtgcag    720
cgcctcctcc cagtgctgtg ccaggctcat gggctgaccc cacagcaggt cgtcgccatt    780
gccagtaacg gcggggggaa gcaggccctc gaaacagtgc agaggctgct gcccgtcttg    840
tgccaagcac acggcctgac acccgagcag gtggtggcca tcgcctctca tgacggcggc    900
aagcaggccc ttgagacagt gcagagactg ttgcccgtgt tgtgtcaggc ccacgggttg    960
acaccccagc aggtggtcgc catcgccagc aatggcgggg gaaagcaggc ccttgagacc   1020
gtgcagcggt tgcttccagt gttgtgccag gcacacggac tgacccctca acaggtggtc   1080
gcaatcgcca gctacaaggg cggaaagcag gctctggaga cagtgcagcg cctcctgccc   1140
gtgctgtgtc aggctcacgg actgacacca cagcaggtgg tcgccatcgc cagtaacggg   1200
ggcggcaagc aggctttgga gaccgtccag agactcctcc ccgtcctttg ccaggcccac   1260
gggttgacac ctcagcaggt cgtcgccatt gcctccaaca acgggggcaa gcaggccctc   1320
gaaactgtgc agaggctgct gcctgtgctg tgccaggctc atgggctgac accccagcag   1380
gtggtggcca ttgcctctaa caacggcggc aaacaggcac tggagaccgt gcaaaggctg   1440
ctgcccgtcc tctgccaagc ccacgggctc actccacagc aggtcgtggc catcgcctca   1500
aacaatggcg ggaagcaggc cctggagact gtgcaaaggc tgctccctgt gctctgccag   1560
gcacacggac tgacccctca gcaggtggtg gcaatcgctt ccaacaacgg gggaaagcag   1620
gccctcgaaa ccgtgcagcg cctcctccca gtgctgtgcc aggcacatgg cctcacaccc   1680
gagcaagtgg tggctatcgc cagccacgac ggagggaagc aggctctgga gaccgtgcag   1740
aggctgctgc ctgtcctgtg ccaggcccac gggcttactc cagagcaggt cgtcgccatc   1800
gccagtcatg atggggggaa gcaggccctt gagacagtcc agcggctgct gccagtcctt   1860
tgccaggctc acggcttgac tcccgagcag gtcgtggcca ttgcctcaaa cattgggggc   1920
aaacaggccc tggagacagt gcaggccctg ctgcccgtgt tgtgtcaggc ccacggcttg   1980
acaccccagc aggtggtcgc cattgcctct aatggcggcg ggagacccgc cttggagagc   2040
attgttgccc agttatctcg ccctgatccg gcgttggccg cgttgaccaa cgaccacctc   2100
gtcgccttgg cctgcctcgg cgggcgtcct gcgctggatg cagtgaaaaa gggattgggg   2160
gatcctatca gccgttccca gctggtgaag tccgagctgg aggagaagaa atccgagttg   2220
aggcacaagc tgaagtacgt gccccacgag tacatcgagc tgatcgagat cgcccggaac   2280
agcacccagg accgtatcct ggagatgaag gtgatggagt tcttcatgaa ggtgtacggc   2340
tacaggggca agcacctggg cggctccagg aagcccgacg gcgccatcta caccgtgggc   2400
tcccccatcg actacggcgt gatcgtggac accaaggcct actccggcgg ctacaacctg   2460
cccatcggcc aggccgacga aatgcagagg tacgtggagg agaaccagac caggaacaag   2520
cacatcaacc ccaacgagtg gtggaaggtg tacccctcca gcgtgaccga gttcaagttc   2580
ctgttcgtgt ccggccactt caagggcaac tacaaggccc agctgaccag gctgaaccac   2640
atcaccaact gcaacggcgc cgtgctgtcc gtggaggagc tcctgatcgg cggcgagatg   2700
atcaaggccg gcaccctgac cctggaggag gtgaggagga agttcaacaa cggcgagatc   2760
aacttcgcgg ccgactgata a                                             2781


<210>  4

<211>  2778
<212>  DNA
<213>  artificial sequence

<220>  
<223>  PD1T3R

<400>  4
atgggcgatc ctaaaaagaa acgtaaggtc atcgatatcg ccgatctacg cacgctcggc     60
tacagccagc agcaacagga gaagatcaaa ccgaaggttc gttcgacagt ggcgcagcac    120
cacgaggcac tggtcggcca cgggtttaca cacgcgcaca tcgttgcgtt aagccaacac    180
ccggcagcgt tagggaccgt cgctgtcaag tatcaggaca tgatcgcagc gttgccagag    240
gcgacacacg aagcgatcgt tggcgtcggc aaacagtggt ccggcgcacg cgctctggag    300
gccttgctca cggtggcggg agagttgaga ggtccaccgt tacagttgga cacaggccaa    360
cttctcaaga ttgcaaaacg tggcggcgtg accgcagtgg aggcagtgca tgcatggcgc    420
aatgcactga cgggtgcccc gctcaacttg acccccgagc aagtcgtcgc aatcgccagc    480
catgatggag ggaagcaagc cctcgaaacc gtgcagcggt tgcttcctgt gctctgccag    540
gcccacggcc ttacccctca gcaggtggtg gccatcgcaa gtaacggagg aggaaagcaa    600
gccttggaga cagtgcagcg cctgttgccc gtgctgtgcc aggcacacgg cctcacacca    660
gagcaggtcg tggccattgc ctcccatgac ggggggaaac aggctctgga gaccgtccag    720
aggctgctgc ccgtcctctg tcaagctcac ggcctgactc cccaacaagt ggtcgccatc    780
gcctctaatg gcggcgggaa gcaggcactg gaaacagtgc agagactgct ccctgtgctt    840
tgccaagctc atgggttgac cccccaacag gtcgtcgcta ttgcctcaaa cggggggggc    900
aagcaggccc ttgagactgt gcagaggctg ttgccagtgc tgtgtcaggc tcacgggctc    960
actccacaac aggtggtcgc aattgccagc aacggcggcg gaaagcaagc tcttgaaacc   1020
gtgcaacgcc tcctgcccgt gctctgtcag gctcatggcc tgacaccaca acaagtcgtg   1080
gccatcgcca gtaataatgg cgggaaacag gctcttgaga ccgtccagag gctgctccca   1140
gtgctctgcc aggcacacgg gctgaccccc gagcaggtgg tggctatcgc cagcaatatt   1200
gggggcaagc aggccctgga aacagtccag gccctgctgc cagtgctttg ccaggctcac   1260
gggctcactc cccagcaggt cgtggcaatc gcctccaacg gcggagggaa gcaggctctg   1320
gagaccgtgc agagactgct gcccgtcttg tgccaggccc acggactcac acctgaacag   1380
gtcgtcgcca ttgcctctca cgatgggggc aaacaagccc tggagacagt gcagcggctg   1440
ttgcctgtgt tgtgccaagc ccacggcttg actcctcaac aagtggtcgc catcgcctca   1500
aatggcggcg gaaaacaagc tctggagaca gtgcagaggt tgctgcccgt cctctgccaa   1560
gcccacggcc tgactcccca acaggtcgtc gccattgcca gcaacaacgg aggaaagcag   1620
gctctcgaaa ctgtgcagcg gctgcttcct gtgctgtgtc aggctcatgg gctgaccccc   1680
gagcaagtgg tggctattgc ctctaatgga ggcaagcaag cccttgagac agtccagagg   1740
ctgttgccag tgctgtgcca ggcccacggg ctcacacccc agcaggtggt cgccatcgcc   1800
agtaacaacg ggggcaaaca ggcattggaa accgtccagc gcctgcttcc agtgctctgc   1860
caggcacacg gactgacacc cgaacaggtg gtggccattg catcccatga tgggggcaag   1920
caggccctgg agaccgtgca gagactcctg ccagtgttgt gccaagctca cggcctcacc   1980
cctcagcaag tcgtggccat cgcctcaaac ggggggggcc ggcctgcact ggagagcatt   2040
gttgcccagt tatctcgccc tgatccggcg ttggccgcgt tgaccaacga ccacctcgtc   2100
gccttggcct gcctcggcgg gcgtcctgcg ctggatgcag tgaaaaaggg attgggggat   2160
cctatcagcc gttcccagct ggtgaagtcc gagctggagg agaagaaatc cgagttgagg   2220
cacaagctga agtacgtgcc ccacgagtac atcgagctga tcgagatcgc ccggaacagc   2280
acccaggacc gtatcctgga gatgaaggtg atggagttct tcatgaaggt gtacggctac   2340
aggggcaagc acctgggcgg ctccaggaag cccgacggcg ccatctacac cgtgggctcc   2400
cccatcgact acggcgtgat cgtggacacc aaggcctact ccggcggcta caacctgccc   2460
atcggccagg ccgacgaaat gcagaggtac gtggaggaga accagaccag gaacaagcac   2520
atcaacccca acgagtggtg gaaggtgtac ccctccagcg tgaccgagtt caagttcctg   2580
ttcgtgtccg gccacttcaa gggcaactac aaggcccagc tgaccaggct gaaccacatc   2640
accaactgca acggcgccgt gctgtccgtg gaggagctcc tgatcggcgg cgagatgatc   2700
aaggccggca ccctgaccct ggaggaggtg aggaggaagt tcaacaacgg cgagatcaac   2760
ttcgcggccg actgataa                                                 2778


<210>  5

<211>  49
<212>  DNA
<213>  artificial sequence

<220>  
<223>  PD1-T3

<400>  5
tacctctgtg gggccatctc cctggccccc aaggcgcaga tcaaagaga                 49


<210>  6

<211>  60
<212>  DNA
<213>  artificial sequence

<220>  
<223>  2A-element

<400>  6
tccggtgagg gcagaggaag tcttctaaca tgcggtgacg tggaggagaa tccgggcccc     60


<210>  7

<211>  1989
<212>  DNA
<213>  artificial sequence

<220>  
<223>  apoptosis CAR

<400>  7
gctttgcctg tcactgcctt gctgcttcca cttgctctgt tgttgcacgc cgcaagaccc     60
gaggtcaagc tccaggaaag cggaccaggg ctggtggccc ctagtcagtc attgagcgtc    120
acttgcaccg tcagcggcgt gtctctgccc gattacggcg tgagctggat cagacagccc    180
ccaaggaagg gactggagtg gctgggcgtc atctggggga gcgagactac ctactacaac    240
agcgccctga agagcaggct gaccatcatt aaggacaact ccaagtccca ggtctttctg    300
aaaatgaaca gcctgcagac tgatgacact gccatctact actgcgccaa gcattactac    360
tacgggggca gctacgctat ggactactgg gggcagggga cctctgtcac agtgtcaagt    420
ggcggaggag gcagtggcgg agggggaagt gggggcggcg gcagcgacat ccagatgacc    480
cagacaacat ccagcctctc cgcctctctg ggcgacagag tgacaatcag ctgccgggcc    540
agtcaggaca tcagcaagta tctcaattgg taccagcaga aaccagacgg gacagtgaaa    600
ttgctgatct accacacatc caggctgcac tcaggagtcc ccagcaggtt ttccggctcc    660
ggctccggga cagattacag tctgaccatt tccaacctgg agcaggagga tattgccaca    720
tacttttgcc agcaaggcaa cactctgccc tataccttcg gcggaggcac aaaactggag    780
attactcggt cggatcccga gcccaaatct cctgacaaaa ctcacacatg cccaccgtgc    840
ccagcacctc ccgtggccgg cccgtcagtg ttcctcttcc ccccaaaacc caaggacacc    900
ctcatgatcg cccggacccc tgaggtcaca tgcgtggtgg tggacgtgag ccacgaggac    960
cctgaggtca agttcaactg gtacgtggac ggcgtggagg tgcataatgc caagacaaag   1020
ccgcgggagg agcagtacaa cagcacgtac cgtgtggtca gcgtcctcac cgtcctgcac   1080
caggactggc tgaatggcaa ggagtacaag tgcaaggtgt ccaacaaagc cctcccagcc   1140
cccatcgaga aaaccatctc caaagccaaa gggcagcccc gagaaccaca ggtgtacacc   1200
ctgcccccat cccgggatga gctgaccaag aaccaggtca gcctgacctg cctggtcaaa   1260
ggcttctatc ccagcgacat cgccgtggag tgggagagca atgggcaacc ggagaacaac   1320
tacaagacca cgcctcccgt gctggactcc gacggctcct tcttcctcta cagcaagctc   1380
accgtggaca agagcaggtg gcagcagggg aacgtgttct catgctccgt gatgcatgag   1440
gccctgcaca atcactatac ccagaaatct ctgagtctga gcccaggcaa gaaggatatt   1500
ttggggtggc tttgccttct tcttttgcca attccactaa ttgtttgggt gaagagaaag   1560
gaagtacaga aaacatgcag aaagcacaga aaggaaaacc aaggttctca tgaatctcca   1620
accttaaatc ctgaaacagt ggcaataaat ttatctgatg ttgacttgag taaatatatc   1680
accactattg ctggagtcat gacactaagt caagttaaag gctttgttcg aaagaatggt   1740
gtcaatgaag ccaaaataga tgagatcaag aatgacaatg tccaagacac agcagaacag   1800
aaagttcaac tgcttcgtaa ttggcatcaa cttcatggaa agaaagaagc gtatgacaca   1860
ttgattgcag atctcaaaaa agccaatctt tgtactcttg cagagaaaat tcagactatc   1920
atcctcaagg acattactag tgactcagaa aattcaaact tcagaaatga aatccagagc   1980
ttggtcgaa                                                           1989


<210>  8

<211>  276
<212>  DNA
<213>  artificial sequence

<220>  
<223>  BGH polyA

<400>  8
tctagagggc ccgtttaaac ccgctgatca gcctcgactg tgccttctag ttgccagcca     60
tctgttgttt gcccctcccc cgtgccttcc ttgaccctgg aaggtgccac tcccactgtc    120
ctttcctaat aaaatgagga aattgcatcg cattgtctga gtaggtgtca ttctattctg    180
gggggtgggg tggggcagga cagcaagggg gaggattggg aagacaatag caggcatgct    240
ggggatgcgg tgggctctat gactagtggc gaattc                              276


<210>  9

<211>  1000
<212>  DNA
<213>  artificial sequence

<220>  
<223>  Lck left homology

<400>  9
gggatagggg gtgcctctgt gtgtgtgtgt gagagtgtgt gtgtgtaggg tgtgtatatg     60
tatagggtgt gtgtgagtgt gtgtgtgtga gagagtgtgt gtgtggcaga atagactgcg    120
gaggtggatt tcatcttgat atgaaaggtc tggaatgcat ggtacattaa actttgagga    180
cagcgctttc caagcactct gaggagcagc cctagagaag gaggagctgc agggactccg    240
ggggcttcaa agtgagggcc ccactctgct tcaggcaaaa caggcacaca tttatcactt    300
tatctatgga gttctgcttg atttcatcag acaaaaaatt tccactgcta aaacaggcaa    360
ataaacaaaa aaaaagttat ggccaacaga gtcactggag ggttttctgc tggggagaag    420
caagcccgtg tttgaaggaa ccctgtgaga tgactgtggg ctgtgtgagg ggaacagcgg    480
gggcttgatg gtggacttcg ggagcagaag cctctttctc agcctcctca gctagacagg    540
ggaattataa taggaggtgt ggcgtgcaca cctctccagt aggggagggt ctgataagtc    600
aggtctctcc caggcttggg aaagtgtgtg tcatctctag gaggtggtcc tcccaacaca    660
gggtactggc agagggagag ggagggggca gaggcaggaa gtgggtaact agactaacaa    720
aggtgcctgt ggcggtttgc ccatcccagg tgggagggtg gggctagggc tcaggggccg    780
tgtgtgaatt tacttgtagc ctgagggctc agagggagca ccggtttgga gctgggaccc    840
cctattttag cttttctgtg gctggtgaat ggggatccca ggatctcaca atctcaggta    900
cttttggaac tttccagggc aaggccccat tatatctgat gttgggggag cagatcttgg    960
gggagcccct tcagccccct cttccattcc ctcagggacc                         1000

<210>  10

<211>  219
<212>  PRT
<213>  artificial sequence

<220>
<223>  Interleukin-12 subunit alpha

<400>  10
Met Cys Pro Ala Arg Ser Leu Leu Leu Val Ala Thr Leu Val Leu Leu 
1               5                   10                  15      


Asp His Leu Ser Leu Ala Arg Asn Leu Pro Val Ala Thr Pro Asp Pro 
            20                  25                  30          


Gly Met Phe Pro Cys Leu His His Ser Gln Asn Leu Leu Arg Ala Val 
        35                  40                  45              


Ser Asn Met Leu Gln Lys Ala Arg Gln Thr Leu Glu Phe Tyr Pro Cys 
    50                  55                  60                  


Thr Ser Glu Glu Ile Asp His Glu Asp Ile Thr Lys Asp Lys Thr Ser 
65                  70                  75                  80  


Thr Val Glu Ala Cys Leu Pro Leu Glu Leu Thr Lys Asn Glu Ser Cys 
                85                  90                  95      


Leu Asn Ser Arg Glu Thr Ser Phe Ile Thr Asn Gly Ser Cys Leu Ala 
            100                 105                 110         


Ser Arg Lys Thr Ser Phe Met Met Ala Leu Cys Leu Ser Ser Ile Tyr 
        115                 120                 125             


Glu Asp Leu Lys Met Tyr Gln Val Glu Phe Lys Thr Met Asn Ala Lys 
    130                 135                 140                 


Leu Leu Met Asp Pro Lys Arg Gln Ile Phe Leu Asp Gln Asn Met Leu 
145                 150                 155                 160 


Ala Val Ile Asp Glu Leu Met Gln Ala Leu Asn Phe Asn Ser Glu Thr 
                165                 170                 175     


Val Pro Gln Lys Ser Ser Leu Glu Glu Pro Asp Phe Tyr Lys Thr Lys 
            180                 185                 190         


Ile Lys Leu Cys Ile Leu Leu His Ala Phe Arg Ile Arg Ala Val Thr 
        195                 200                 205             


Ile Asp Arg Val Met Ser Tyr Leu Asn Ala Ser 
    210                 215                 


<210>  11

<211>  328
<212>  PRT
<213>  artificial sequence

<220>
<223>  Interleukin-12 subunit beta

<400>  11
Met Cys His Gln Gln Leu Val Ile Ser Trp Phe Ser Leu Val Phe Leu 
1               5                   10                  15      


Ala Ser Pro Leu Val Ala Ile Trp Glu Leu Lys Lys Asp Val Tyr Val 
            20                  25                  30          


Val Glu Leu Asp Trp Tyr Pro Asp Ala Pro Gly Glu Met Val Val Leu 
        35                  40                  45              


Thr Cys Asp Thr Pro Glu Glu Asp Gly Ile Thr Trp Thr Leu Asp Gln 
    50                  55                  60                  


Ser Ser Glu Val Leu Gly Ser Gly Lys Thr Leu Thr Ile Gln Val Lys 
65                  70                  75                  80  


Glu Phe Gly Asp Ala Gly Gln Tyr Thr Cys His Lys Gly Gly Glu Val 
                85                  90                  95      


Leu Ser His Ser Leu Leu Leu Leu His Lys Lys Glu Asp Gly Ile Trp 
            100                 105                 110         


Ser Thr Asp Ile Leu Lys Asp Gln Lys Glu Pro Lys Asn Lys Thr Phe 
        115                 120                 125             


Leu Arg Cys Glu Ala Lys Asn Tyr Ser Gly Arg Phe Thr Cys Trp Trp 
    130                 135                 140                 


Leu Thr Thr Ile Ser Thr Asp Leu Thr Phe Ser Val Lys Ser Ser Arg 
145                 150                 155                 160 


Gly Ser Ser Asp Pro Gln Gly Val Thr Cys Gly Ala Ala Thr Leu Ser 
                165                 170                 175     


Ala Glu Arg Val Arg Gly Asp Asn Lys Glu Tyr Glu Tyr Ser Val Glu 
            180                 185                 190         


Cys Gln Glu Asp Ser Ala Cys Pro Ala Ala Glu Glu Ser Leu Pro Ile 
        195                 200                 205             


Glu Val Met Val Asp Ala Val His Lys Leu Lys Tyr Glu Asn Tyr Thr 
    210                 215                 220                 


Ser Ser Phe Phe Ile Arg Asp Ile Ile Lys Pro Asp Pro Pro Lys Asn 
225                 230                 235                 240 


Leu Gln Leu Lys Pro Leu Lys Asn Ser Arg Gln Val Glu Val Ser Trp 
                245                 250                 255     


Glu Tyr Pro Asp Thr Trp Ser Thr Pro His Ser Tyr Phe Ser Leu Thr 
            260                 265                 270         


Phe Cys Val Gln Val Gln Gly Lys Ser Lys Arg Glu Lys Lys Asp Arg 
        275                 280                 285             


Val Phe Thr Asp Lys Thr Ser Ala Thr Val Ile Cys Arg Lys Asn Ala 
    290                 295                 300                 


Ser Ile Ser Val Arg Ala Gln Asp Arg Tyr Tyr Ser Ser Ser Trp Ser 
305                 310                 315                 320 


Glu Trp Ala Ser Val Pro Cys Ser 
                325             

<210>  12

<211>  1000
<212>  DNA
<213>  artificial sequence

<220>  
<223>  lck right homology

<400>  12
ggctgtggct gcagctcaca cccggaagat gactggatgg aaaacatcga tgtgtgtgag     60
aactgccatt atcccatagt cccactggat ggcaagggca cggtaagagg cgagacaggg    120
gccttggtga gggagttggg tagagaatgc aacccaggag aaagaaatga ccagcactac    180
aggcccttga aagaatagag tggccctctc ccctgaaata cagaaaggaa aagaggccca    240
gagaggggaa gggaatctcc taagatcaca cagaaagtag ttggtaaact cagggataac    300
atctaaccag gctggagagg ctgagagcag agcagggggg aagggggcca gggtctgacc    360
caatcttctg ctttctgacc ccaccctcat cccccactcc acagctgctc atccgaaatg    420
gctctgaggt gcgggaccca ctggttacct acgaaggctc caatccgccg gcttccccac    480
tgcaaggtga ccccaggcag cagggcctga aagacaaggc ctgcggatcc ctggctgttg    540
gcttccacct ctcccccacc tactttctcc ccggtcttgc cttccttgtc ccccaccctg    600
taactccagg cttcctgccg atcccagctc ggttctccct gatgcccctt gtctttacag    660
acaacctggt tatcgctctg cacagctatg agccctctca cgacggagat ctgggctttg    720
agaaggggga acagctccgc atcctggagc agtgagtccc tctccacctt gctctggcgg    780
agtccgtgag ggagcggcga tctccgcgac ccgcagccct cctgcggccc ttgaccagct    840
cggggtggcc gcccttggga caaaattcga ggctcagtat tgctgagcca gggttggggg    900
aggctggctt aaggggtgga ggggtctttg agggagggtc tcaggtcgac ggctgagcga    960
gccacactga cccacctccg tggcgcagga gcggcgagtg                         1000


<210>  13

<211>  1992
<212>  DNA
<213>  artificial sequence

<220>  
<223>  apoptosis CAR

<400>  13
atggctttgc ctgtcactgc cttgctgctt ccacttgctc tgttgttgca cgccgcaaga     60
cccgaggtca agctccagga aagcggacca gggctggtgg cccctagtca gtcattgagc    120
gtcacttgca ccgtcagcgg cgtgtctctg cccgattacg gcgtgagctg gatcagacag    180
cccccaagga agggactgga gtggctgggc gtcatctggg ggagcgagac tacctactac    240
aacagcgccc tgaagagcag gctgaccatc attaaggaca actccaagtc ccaggtcttt    300
ctgaaaatga acagcctgca gactgatgac actgccatct actactgcgc caagcattac    360
tactacgggg gcagctacgc tatggactac tgggggcagg ggacctctgt cacagtgtca    420
agtggcggag gaggcagtgg cggaggggga agtgggggcg gcggcagcga catccagatg    480
acccagacaa catccagcct ctccgcctct ctgggcgaca gagtgacaat cagctgccgg    540
gccagtcagg acatcagcaa gtatctcaat tggtaccagc agaaaccaga cgggacagtg    600
aaattgctga tctaccacac atccaggctg cactcaggag tccccagcag gttttccggc    660
tccggctccg ggacagatta cagtctgacc atttccaacc tggagcagga ggatattgcc    720
acatactttt gccagcaagg caacactctg ccctatacct tcggcggagg cacaaaactg    780
gagattactc ggtcggatcc cgagcccaaa tctcctgaca aaactcacac atgcccaccg    840
tgcccagcac ctcccgtggc cggcccgtca gtgttcctct tccccccaaa acccaaggac    900
accctcatga tcgcccggac ccctgaggtc acatgcgtgg tggtggacgt gagccacgag    960
gaccctgagg tcaagttcaa ctggtacgtg gacggcgtgg aggtgcataa tgccaagaca   1020
aagccgcggg aggagcagta caacagcacg taccgtgtgg tcagcgtcct caccgtcctg   1080
caccaggact ggctgaatgg caaggagtac aagtgcaagg tgtccaacaa agccctccca   1140
gcccccatcg agaaaaccat ctccaaagcc aaagggcagc cccgagaacc acaggtgtac   1200
accctgcccc catcccggga tgagctgacc aagaaccagg tcagcctgac ctgcctggtc   1260
aaaggcttct atcccagcga catcgccgtg gagtgggaga gcaatgggca accggagaac   1320
aactacaaga ccacgcctcc cgtgctggac tccgacggct ccttcttcct ctacagcaag   1380
ctcaccgtgg acaagagcag gtggcagcag gggaacgtgt tctcatgctc cgtgatgcat   1440
gaggccctgc acaatcacta tacccagaaa tctctgagtc tgagcccagg caagaaggat   1500
attttggggt ggctttgcct tcttcttttg ccaattccac taattgtttg ggtgaagaga   1560
aaggaagtac agaaaacatg cagaaagcac agaaaggaaa accaaggttc tcatgaatct   1620
ccaaccttaa atcctgaaac agtggcaata aatttatctg atgttgactt gagtaaatat   1680
atcaccacta ttgctggagt catgacacta agtcaagtta aaggctttgt tcgaaagaat   1740
ggtgtcaatg aagccaaaat agatgagatc aagaatgaca atgtccaaga cacagcagaa   1800
cagaaagttc aactgcttcg taattggcat caacttcatg gaaagaaaga agcgtatgac   1860
acattgattg cagatctcaa aaaagccaat ctttgtactc ttgcagagaa aattcagact   1920
atcatcctca aggacattac tagtgactca gaaaattcaa acttcagaaa tgaaatccag   1980
agcttggtcg aa                                                       1992


<210>  14

<211>  1000
<212>  DNA
<213>  artificial sequence

<220>  
<223>  Lck left homology

<400>  14
ctcataacaa ttctatgagg taggaacagt tatttactct attttccaaa taaggaaact     60
gggctcgccc aaggttccac aactaacatg tgtgtattat tgagcattta atttacacca    120
gggaagcagg ttgtggtggt gtgcacctgt tgtccagcta tttaggaggc tgaggtgaaa    180
ggatcacttg aacggaggag ttcaaatttg caatgtgcta tgattgtgcc tgtgaacagc    240
tgctgcactc cagcctgggc aacatagtga gatcccttat ctaaaacatt ttttttaagt    300
aaataatcag gtgggcacgg tggctcacgc ctgtaatcca gcactttggg aggctgaggc    360
gggcggatca cctgaggtca ggagttcaag accagcctga ccaacatgga gaaacccgtc    420
tctactaaaa atacaaaatt agcttggcgt ggtggtgcat gcctgtaatc ccagctactc    480
gagaagctga ggcaggagaa ttgtttgaac ctgggaggtg gaggttgcgg tgagccgaga    540
tcgcaccatt gcactccagc ctgggcaaca agagtgaaat tgcatctcaa aaaaaaagaa    600
aaggaaataa tctataccag gcactccaag tggtgtgact gatattcaac aagtacctct    660
agtgtgacct taccattgat gaagaccaag attcttttgg attggtgctc acactgtgcc    720
agttaaatat tccgaacatt acccttgcct gtgggcttcc agtgcctgac cttgatgtcc    780
tttcacccat caacccgtag ggatgaccaa cccggaggtg attcagaacc tggagcgagg    840
ctaccgcatg gtgcgccctg acaactgtcc agaggagctg taccaactca tgaggctgtg    900
ctggaaggag cgcccagagg accggcccac ctttgactac ctgcgcagtg tgctggagga    960
cttcttcacg gccacagagg gccagtacca gcctcagcct                         1000


<210>  15

<211>  1000
<212>  DNA
<213>  artificial sequence

<220
<223>  lck right homology

<400>  15
gaggccttga gaggccctgg ggttctcccc ctttctctcc agcctgactt ggggagatgg     60
agttcttgtg ccatagtcac atggcctatg cacatatgga ctctgcacat gaatcccacc    120
cacatgtgac acatatgcac cttgtgtctg tacacgtgtc ctgtagttgc gtggactctg    180
cacatgtctt gtacatgtgt agcctgtgca tgtatgtctt ggacactgta caaggtaccc    240
ctttctggct ctcccatttc ctgagaccac agagagaggg gagaagcctg ggattgacag    300
aagcttctgc ccacctactt ttctttcctc agatcatcca gaagttcctc aagggccagg    360
actttatcta atacctctgt gtgctcctcc ttggtgcctg gcctggcaca catcaggagt    420
tcaataaatg tctgttgatg actgttgtac atctctttgc tgtccactct ttgtgggtgg    480
gcagtggggg ttaagaaaat ggtaattagg tcaccctgag ttggggtgaa agatgggatg    540
agtggatgtc tggaggctct gcagacccct tcaaatggga cagtgctcct cacccctccc    600
caaaggattc agggtgactc ctacctggaa tcccttaggg aatgggtgcg tcaaaggacc    660
ttcctcccca ttataaaagg gcaacagcat tttttactga ttcaagggct atatttgacc    720
tcagattttg tttttttaag gctagtcaaa tgaagcggcg ggaatggagg aggaacaaat    780
aaatctgtaa ctatcctcag attttttttt ttttttgaga ctgggtctca ctttttcatc    840
caggctggag tgcagtcgca tgatcacggc tcactgtagc ctcaacctct ccagctcaaa    900
tgctcctcct gtctcagcct cccgagtacc tgggactact ttcttgaggc caggaattca    960
agaacagagt aagatcctgg tctccaaaaa aagttttaaa                         1000


<210>  16

<211>  936
<212>  PRT
<213>  artificial sequence

<220>
<223>  TALEN TRAC

<400>  16
Met Gly Asp Pro Lys Lys Lys Arg Lys Val Ile Asp Tyr Pro Tyr Asp 
1               5                   10                  15      


Val Pro Asp Tyr Ala Ile Asp Ile Ala Asp Leu Arg Thr Leu Gly Tyr 
            20                  25                  30          


Ser Gln Gln Gln Gln Glu Lys Ile Lys Pro Lys Val Arg Ser Thr Val 
        35                  40                  45              


Ala Gln His His Glu Ala Leu Val Gly His Gly Phe Thr His Ala His 
    50                  55                  60                  


Ile Val Ala Leu Ser Gln His Pro Ala Ala Leu Gly Thr Val Ala Val 
65                  70                  75                  80  


Lys Tyr Gln Asp Met Ile Ala Ala Leu Pro Glu Ala Thr His Glu Ala 
                85                  90                  95      


Ile Val Gly Val Gly Lys Gln Trp Ser Gly Ala Arg Ala Leu Glu Ala 
            100                 105                 110         


Leu Leu Thr Val Ala Gly Glu Leu Arg Gly Pro Pro Leu Gln Leu Asp 
        115                 120                 125             


Thr Gly Gln Leu Leu Lys Ile Ala Lys Arg Gly Gly Val Thr Ala Val 
    130                 135                 140                 


Glu Ala Val His Ala Trp Arg Asn Ala Leu Thr Gly Ala Pro Leu Asn 
145                 150                 155                 160 


Leu Thr Pro Gln Gln Val Val Ala Ile Ala Ser Asn Gly Gly Gly Lys 
                165                 170                 175     


Gln Ala Leu Glu Thr Val Gln Arg Leu Leu Pro Val Leu Cys Gln Ala 
            180                 185                 190         


His Gly Leu Thr Pro Gln Gln Val Val Ala Ile Ala Ser Asn Asn Gly 
        195                 200                 205             


Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu Leu Pro Val Leu Cys 
    210                 215                 220                 


Gln Ala His Gly Leu Thr Pro Gln Gln Val Val Ala Ile Ala Ser Asn 
225                 230                 235                 240 


Gly Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu Leu Pro Val 
                245                 250                 255     


Leu Cys Gln Ala His Gly Leu Thr Pro Glu Gln Val Val Ala Ile Ala 
            260                 265                 270         


Ser His Asp Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu Leu 
        275                 280                 285             


Pro Val Leu Cys Gln Ala His Gly Leu Thr Pro Glu Gln Val Val Ala 
    290                 295                 300                 


Ile Ala Ser His Asp Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg 
305                 310                 315                 320 


Leu Leu Pro Val Leu Cys Gln Ala His Gly Leu Thr Pro Glu Gln Val 
                325                 330                 335     


Val Ala Ile Ala Ser His Asp Gly Gly Lys Gln Ala Leu Glu Thr Val 
            340                 345                 350         


Gln Arg Leu Leu Pro Val Leu Cys Gln Ala His Gly Leu Thr Pro Glu 
        355                 360                 365             


Gln Val Val Ala Ile Ala Ser Asn Ile Gly Gly Lys Gln Ala Leu Glu 
    370                 375                 380                 


Thr Val Gln Ala Leu Leu Pro Val Leu Cys Gln Ala His Gly Leu Thr 
385                 390                 395                 400 


Pro Glu Gln Val Val Ala Ile Ala Ser His Asp Gly Gly Lys Gln Ala 
                405                 410                 415     


Leu Glu Thr Val Gln Arg Leu Leu Pro Val Leu Cys Gln Ala His Gly 
            420                 425                 430         


Leu Thr Pro Glu Gln Val Val Ala Ile Ala Ser Asn Ile Gly Gly Lys 
        435                 440                 445             


Gln Ala Leu Glu Thr Val Gln Ala Leu Leu Pro Val Leu Cys Gln Ala 
    450                 455                 460                 


His Gly Leu Thr Pro Gln Gln Val Val Ala Ile Ala Ser Asn Asn Gly 
465                 470                 475                 480 


Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu Leu Pro Val Leu Cys 
                485                 490                 495     


Gln Ala His Gly Leu Thr Pro Glu Gln Val Val Ala Ile Ala Ser Asn 
            500                 505                 510         


Ile Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Ala Leu Leu Pro Val 
        515                 520                 525             


Leu Cys Gln Ala His Gly Leu Thr Pro Gln Gln Val Val Ala Ile Ala 
    530                 535                 540                 


Ser Asn Gly Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu Leu 
545                 550                 555                 560 


Pro Val Leu Cys Gln Ala His Gly Leu Thr Pro Glu Gln Val Val Ala 
                565                 570                 575     


Ile Ala Ser Asn Ile Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Ala 
            580                 585                 590         


Leu Leu Pro Val Leu Cys Gln Ala His Gly Leu Thr Pro Gln Gln Val 
        595                 600                 605             


Val Ala Ile Ala Ser Asn Gly Gly Gly Lys Gln Ala Leu Glu Thr Val 
    610                 615                 620                 


Gln Arg Leu Leu Pro Val Leu Cys Gln Ala His Gly Leu Thr Pro Glu 
625                 630                 635                 640 


Gln Val Val Ala Ile Ala Ser His Asp Gly Gly Lys Gln Ala Leu Glu 
                645                 650                 655     


Thr Val Gln Arg Leu Leu Pro Val Leu Cys Gln Ala His Gly Leu Thr 
            660                 665                 670         


Pro Gln Gln Val Val Ala Ile Ala Ser Asn Gly Gly Gly Arg Pro Ala 
        675                 680                 685             


Leu Glu Ser Ile Val Ala Gln Leu Ser Arg Pro Asp Pro Ala Leu Ala 
    690                 695                 700                 


Ala Leu Thr Asn Asp His Leu Val Ala Leu Ala Cys Leu Gly Gly Arg 
705                 710                 715                 720 


Pro Ala Leu Asp Ala Val Lys Lys Gly Leu Gly Asp Pro Ile Ser Arg 
                725                 730                 735     


Ser Gln Leu Val Lys Ser Glu Leu Glu Glu Lys Lys Ser Glu Leu Arg 
            740                 745                 750         


His Lys Leu Lys Tyr Val Pro His Glu Tyr Ile Glu Leu Ile Glu Ile 
        755                 760                 765             


Ala Arg Asn Ser Thr Gln Asp Arg Ile Leu Glu Met Lys Val Met Glu 
    770                 775                 780                 


Phe Phe Met Lys Val Tyr Gly Tyr Arg Gly Lys His Leu Gly Gly Ser 
785                 790                 795                 800 


Arg Lys Pro Asp Gly Ala Ile Tyr Thr Val Gly Ser Pro Ile Asp Tyr 
                805                 810                 815     


Gly Val Ile Val Asp Thr Lys Ala Tyr Ser Gly Gly Tyr Asn Leu Pro 
            820                 825                 830         


Ile Gly Gln Ala Asp Glu Met Gln Arg Tyr Val Glu Glu Asn Gln Thr 
        835                 840                 845             


Arg Asn Lys His Ile Asn Pro Asn Glu Trp Trp Lys Val Tyr Pro Ser 
    850                 855                 860                 


Ser Val Thr Glu Phe Lys Phe Leu Phe Val Ser Gly His Phe Lys Gly 
865                 870                 875                 880 


Asn Tyr Lys Ala Gln Leu Thr Arg Leu Asn His Ile Thr Asn Cys Asn 
                885                 890                 895     


Gly Ala Val Leu Ser Val Glu Glu Leu Leu Ile Gly Gly Glu Met Ile 
            900                 905                 910         


Lys Ala Gly Thr Leu Thr Leu Glu Glu Val Arg Arg Lys Phe Asn Asn 
        915                 920                 925             


Gly Glu Ile Asn Phe Ala Ala Asp 
    930                 935     


<210>  17

<211>  942
<212>  PRT
<213>  artificial sequence

<220>
<223>  TALEN TRAC

<400>  17
Met Gly Asp Pro Lys Lys Lys Arg Lys Val Ile Asp Lys Glu Thr Ala 
1               5                   10                  15      


Ala Ala Lys Phe Glu Arg Gln His Met Asp Ser Ile Asp Ile Ala Asp 
            20                  25                  30          


Leu Arg Thr Leu Gly Tyr Ser Gln Gln Gln Gln Glu Lys Ile Lys Pro 
        35                  40                  45              


Lys Val Arg Ser Thr Val Ala Gln His His Glu Ala Leu Val Gly His 
    50                  55                  60                  


Gly Phe Thr His Ala His Ile Val Ala Leu Ser Gln His Pro Ala Ala 
65                  70                  75                  80  


Leu Gly Thr Val Ala Val Lys Tyr Gln Asp Met Ile Ala Ala Leu Pro 
                85                  90                  95      


Glu Ala Thr His Glu Ala Ile Val Gly Val Gly Lys Gln Trp Ser Gly 
            100                 105                 110         


Ala Arg Ala Leu Glu Ala Leu Leu Thr Val Ala Gly Glu Leu Arg Gly 
        115                 120                 125             


Pro Pro Leu Gln Leu Asp Thr Gly Gln Leu Leu Lys Ile Ala Lys Arg 
    130                 135                 140                 


Gly Gly Val Thr Ala Val Glu Ala Val His Ala Trp Arg Asn Ala Leu 
145                 150                 155                 160 


Thr Gly Ala Pro Leu Asn Leu Thr Pro Glu Gln Val Val Ala Ile Ala 
                165                 170                 175     


Ser His Asp Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu Leu 
            180                 185                 190         


Pro Val Leu Cys Gln Ala His Gly Leu Thr Pro Gln Gln Val Val Ala 
        195                 200                 205             


Ile Ala Ser Asn Gly Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg 
    210                 215                 220                 


Leu Leu Pro Val Leu Cys Gln Ala His Gly Leu Thr Pro Glu Gln Val 
225                 230                 235                 240 


Val Ala Ile Ala Ser His Asp Gly Gly Lys Gln Ala Leu Glu Thr Val 
                245                 250                 255     


Gln Arg Leu Leu Pro Val Leu Cys Gln Ala His Gly Leu Thr Pro Glu 
            260                 265                 270         


Gln Val Val Ala Ile Ala Ser Asn Ile Gly Gly Lys Gln Ala Leu Glu 
        275                 280                 285             


Thr Val Gln Ala Leu Leu Pro Val Leu Cys Gln Ala His Gly Leu Thr 
    290                 295                 300                 


Pro Gln Gln Val Val Ala Ile Ala Ser Asn Asn Gly Gly Lys Gln Ala 
305                 310                 315                 320 


Leu Glu Thr Val Gln Arg Leu Leu Pro Val Leu Cys Gln Ala His Gly 
                325                 330                 335     


Leu Thr Pro Glu Gln Val Val Ala Ile Ala Ser His Asp Gly Gly Lys 
            340                 345                 350         


Gln Ala Leu Glu Thr Val Gln Arg Leu Leu Pro Val Leu Cys Gln Ala 
        355                 360                 365             


His Gly Leu Thr Pro Gln Gln Val Val Ala Ile Ala Ser Asn Gly Gly 
    370                 375                 380                 


Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu Leu Pro Val Leu Cys 
385                 390                 395                 400 


Gln Ala His Gly Leu Thr Pro Gln Gln Val Val Ala Ile Ala Ser Asn 
                405                 410                 415     


Asn Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu Leu Pro Val 
            420                 425                 430         


Leu Cys Gln Ala His Gly Leu Thr Pro Gln Gln Val Val Ala Ile Ala 
        435                 440                 445             


Ser Asn Asn Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu Leu 
    450                 455                 460                 


Pro Val Leu Cys Gln Ala His Gly Leu Thr Pro Gln Gln Val Val Ala 
465                 470                 475                 480 


Ile Ala Ser Asn Gly Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg 
                485                 490                 495     


Leu Leu Pro Val Leu Cys Gln Ala His Gly Leu Thr Pro Glu Gln Val 
            500                 505                 510         


Val Ala Ile Ala Ser Asn Ile Gly Gly Lys Gln Ala Leu Glu Thr Val 
        515                 520                 525             


Gln Ala Leu Leu Pro Val Leu Cys Gln Ala His Gly Leu Thr Pro Glu 
    530                 535                 540                 


Gln Val Val Ala Ile Ala Ser His Asp Gly Gly Lys Gln Ala Leu Glu 
545                 550                 555                 560 


Thr Val Gln Arg Leu Leu Pro Val Leu Cys Gln Ala His Gly Leu Thr 
                565                 570                 575     


Pro Glu Gln Val Val Ala Ile Ala Ser Asn Ile Gly Gly Lys Gln Ala 
            580                 585                 590         


Leu Glu Thr Val Gln Ala Leu Leu Pro Val Leu Cys Gln Ala His Gly 
        595                 600                 605             


Leu Thr Pro Glu Gln Val Val Ala Ile Ala Ser His Asp Gly Gly Lys 
    610                 615                 620                 


Gln Ala Leu Glu Thr Val Gln Arg Leu Leu Pro Val Leu Cys Gln Ala 
625                 630                 635                 640 


His Gly Leu Thr Pro Gln Gln Val Val Ala Ile Ala Ser Asn Asn Gly 
                645                 650                 655     


Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu Leu Pro Val Leu Cys 
            660                 665                 670         


Gln Ala His Gly Leu Thr Pro Gln Gln Val Val Ala Ile Ala Ser Asn 
        675                 680                 685             


Gly Gly Gly Arg Pro Ala Leu Glu Ser Ile Val Ala Gln Leu Ser Arg 
    690                 695                 700                 


Pro Asp Pro Ala Leu Ala Ala Leu Thr Asn Asp His Leu Val Ala Leu 
705                 710                 715                 720 


Ala Cys Leu Gly Gly Arg Pro Ala Leu Asp Ala Val Lys Lys Gly Leu 
                725                 730                 735     


Gly Asp Pro Ile Ser Arg Ser Gln Leu Val Lys Ser Glu Leu Glu Glu 
            740                 745                 750         


Lys Lys Ser Glu Leu Arg His Lys Leu Lys Tyr Val Pro His Glu Tyr 
        755                 760                 765             


Ile Glu Leu Ile Glu Ile Ala Arg Asn Ser Thr Gln Asp Arg Ile Leu 
    770                 775                 780                 


Glu Met Lys Val Met Glu Phe Phe Met Lys Val Tyr Gly Tyr Arg Gly 
785                 790                 795                 800 


Lys His Leu Gly Gly Ser Arg Lys Pro Asp Gly Ala Ile Tyr Thr Val 
                805                 810                 815     


Gly Ser Pro Ile Asp Tyr Gly Val Ile Val Asp Thr Lys Ala Tyr Ser 
            820                 825                 830         


Gly Gly Tyr Asn Leu Pro Ile Gly Gln Ala Asp Glu Met Gln Arg Tyr 
        835                 840                 845             


Val Glu Glu Asn Gln Thr Arg Asn Lys His Ile Asn Pro Asn Glu Trp 
    850                 855                 860                 


Trp Lys Val Tyr Pro Ser Ser Val Thr Glu Phe Lys Phe Leu Phe Val 
865                 870                 875                 880 


Ser Gly His Phe Lys Gly Asn Tyr Lys Ala Gln Leu Thr Arg Leu Asn 
                885                 890                 895     


His Ile Thr Asn Cys Asn Gly Ala Val Leu Ser Val Glu Glu Leu Leu 
            900                 905                 910         


Ile Gly Gly Glu Met Ile Lys Ala Gly Thr Leu Thr Leu Glu Glu Val 
        915                 920                 925             


Arg Arg Lys Phe Asn Asn Gly Glu Ile Asn Phe Ala Ala Asp 
    930                 935                 940         


<210>  18

<211>  913
<212>  PRT
<213>  artificial sequence

<220>
<223>  TALEN CD25

<400>  18
Met Gly Asp Pro Lys Lys Lys Arg Lys Val Ile Asp Tyr Pro Tyr Asp 
1               5                   10                  15      


Val Pro Asp Tyr Ala Ile Asp Ile Ala Asp Leu Arg Thr Leu Gly Tyr 
            20                  25                  30          


Ser Gln Gln Gln Gln Glu Lys Ile Lys Pro Lys Val Arg Ser Thr Val 
        35                  40                  45              


Ala Gln His His Glu Ala Leu Val Gly His Gly Phe Thr His Ala His 
    50                  55                  60                  


Ile Val Ala Leu Ser Gln His Pro Ala Ala Leu Gly Thr Val Ala Val 
65                  70                  75                  80  


Lys Tyr Gln Asp Met Ile Ala Ala Leu Pro Glu Ala Thr His Glu Ala 
                85                  90                  95      


Ile Val Gly Val Gly Lys Gln Trp Ser Gly Ala Arg Ala Leu Glu Ala 
            100                 105                 110         


Leu Leu Thr Val Ala Gly Glu Leu Arg Gly Pro Pro Leu Gln Leu Asp 
        115                 120                 125             


Thr Gly Gln Leu Leu Lys Ile Ala Lys Arg Gly Gly Val Thr Ala Val 
    130                 135                 140                 


Glu Ala Val His Ala Trp Arg Asn Ala Leu Thr Gly Ala Pro Leu Asn 
145                 150                 155                 160 


Leu Thr Pro Gln Gln Val Val Ala Ile Ala Ser Asn Asn Gly Gly Lys 
                165                 170                 175     


Gln Ala Leu Glu Thr Val Gln Arg Leu Leu Pro Val Leu Cys Gln Ala 
            180                 185                 190         


His Gly Leu Thr Pro Gln Gln Val Val Ala Ile Ala Ser Asn Gly Gly 
        195                 200                 205             


Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu Leu Pro Val Leu Cys 
    210                 215                 220                 


Gln Ala His Gly Leu Thr Pro Gln Gln Val Val Ala Ile Ala Ser Asn 
225                 230                 235                 240 


Gly Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu Leu Pro Val 
                245                 250                 255     


Leu Cys Gln Ala His Gly Leu Thr Pro Glu Gln Val Val Ala Ile Ala 
            260                 265                 270         


Ser His Asp Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu Leu 
        275                 280                 285             


Pro Val Leu Cys Gln Ala His Gly Leu Thr Pro Gln Gln Val Val Ala 
    290                 295                 300                 


Ile Ala Ser Asn Gly Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg 
305                 310                 315                 320 


Leu Leu Pro Val Leu Cys Gln Ala His Gly Leu Thr Pro Gln Gln Val 
                325                 330                 335     


Val Ala Ile Ala Ser Asn Gly Gly Gly Lys Gln Ala Leu Glu Thr Val 
            340                 345                 350         


Gln Arg Leu Leu Pro Val Leu Cys Gln Ala His Gly Leu Thr Pro Gln 
        355                 360                 365             


Gln Val Val Ala Ile Ala Ser Asn Gly Gly Gly Lys Gln Ala Leu Glu 
    370                 375                 380                 


Thr Val Gln Arg Leu Leu Pro Val Leu Cys Gln Ala His Gly Leu Thr 
385                 390                 395                 400 


Pro Gln Gln Val Val Ala Ile Ala Ser Asn Gly Gly Gly Lys Gln Ala 
                405                 410                 415     


Leu Glu Thr Val Gln Arg Leu Leu Pro Val Leu Cys Gln Ala His Gly 
            420                 425                 430         


Leu Thr Pro Gln Gln Val Val Ala Ile Ala Ser Asn Asn Gly Gly Lys 
        435                 440                 445             


Gln Ala Leu Glu Thr Val Gln Arg Leu Leu Pro Val Leu Cys Gln Ala 
    450                 455                 460                 


His Gly Leu Thr Pro Gln Gln Val Val Ala Ile Ala Ser Asn Asn Gly 
465                 470                 475                 480 


Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu Leu Pro Val Leu Cys 
                485                 490                 495     


Gln Ala His Gly Leu Thr Pro Gln Gln Val Val Ala Ile Ala Ser Asn 
            500                 505                 510         


Gly Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu Leu Pro Val 
        515                 520                 525             


Leu Cys Gln Ala His Gly Leu Thr Pro Gln Gln Val Val Ala Ile Ala 
    530                 535                 540                 


Ser Asn Gly Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu Leu 
545                 550                 555                 560 


Pro Val Leu Cys Gln Ala His Gly Leu Thr Pro Gln Gln Val Val Ala 
                565                 570                 575     


Ile Ala Ser Asn Gly Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg 
            580                 585                 590         


Leu Leu Pro Val Leu Cys Gln Ala His Gly Leu Thr Pro Gln Gln Val 
        595                 600                 605             


Val Ala Ile Ala Ser Asn Gly Gly Gly Lys Gln Ala Leu Glu Thr Val 
    610                 615                 620                 


Gln Arg Leu Leu Pro Val Leu Cys Gln Ala His Gly Leu Thr Pro Glu 
625                 630                 635                 640 


Gln Val Val Ala Ile Ala Ser His Asp Gly Gly Lys Gln Ala Leu Glu 
                645                 650                 655     


Thr Val Gln Arg Leu Leu Pro Val Leu Cys Gln Ala His Gly Leu Thr 
            660                 665                 670         


Pro Gln Gln Val Val Ala Ile Ala Ser Asn Gly Gly Gly Arg Pro Ala 
        675                 680                 685             


Leu Glu Ser Ile Val Ala Gln Leu Ser Arg Pro Asp Pro Ser Gly Ser 
    690                 695                 700                 


Gly Ser Gly Gly Asp Pro Ile Ser Arg Ser Gln Leu Val Lys Ser Glu 
705                 710                 715                 720 


Leu Glu Glu Lys Lys Ser Glu Leu Arg His Lys Leu Lys Tyr Val Pro 
                725                 730                 735     


His Glu Tyr Ile Glu Leu Ile Glu Ile Ala Arg Asn Ser Thr Gln Asp 
            740                 745                 750         


Arg Ile Leu Glu Met Lys Val Met Glu Phe Phe Met Lys Val Tyr Gly 
        755                 760                 765             


Tyr Arg Gly Lys His Leu Gly Gly Ser Arg Lys Pro Asp Gly Ala Ile 
    770                 775                 780                 


Tyr Thr Val Gly Ser Pro Ile Asp Tyr Gly Val Ile Val Asp Thr Lys 
785                 790                 795                 800 


Ala Tyr Ser Gly Gly Tyr Asn Leu Pro Ile Gly Gln Ala Asp Glu Met 
                805                 810                 815     


Gln Arg Tyr Val Glu Glu Asn Gln Thr Arg Asn Lys His Ile Asn Pro 
            820                 825                 830         


Asn Glu Trp Trp Lys Val Tyr Pro Ser Ser Val Thr Glu Phe Lys Phe 
        835                 840                 845             


Leu Phe Val Ser Gly His Phe Lys Gly Asn Tyr Lys Ala Gln Leu Thr 
    850                 855                 860                 


Arg Leu Asn His Ile Thr Asn Cys Asn Gly Ala Val Leu Ser Val Glu 
865                 870                 875                 880 


Glu Leu Leu Ile Gly Gly Glu Met Ile Lys Ala Gly Thr Leu Thr Leu 
                885                 890                 895     


Glu Glu Val Arg Arg Lys Phe Asn Asn Gly Glu Ile Asn Phe Ala Ala 
            900                 905                 910         


Asp 
    


<210>  19

<211>  913
<212>  PRT
<213>  artificial sequence

<220>
<223>  TALEN CD25

<400>  19
Met Gly Asp Pro Lys Lys Lys Arg Lys Val Ile Asp Tyr Pro Tyr Asp 
1               5                   10                  15      


Val Pro Asp Tyr Ala Ile Asp Ile Ala Asp Leu Arg Thr Leu Gly Tyr 
            20                  25                  30          


Ser Gln Gln Gln Gln Glu Lys Ile Lys Pro Lys Val Arg Ser Thr Val 
        35                  40                  45              


Ala Gln His His Glu Ala Leu Val Gly His Gly Phe Thr His Ala His 
    50                  55                  60                  


Ile Val Ala Leu Ser Gln His Pro Ala Ala Leu Gly Thr Val Ala Val 
65                  70                  75                  80  


Lys Tyr Gln Asp Met Ile Ala Ala Leu Pro Glu Ala Thr His Glu Ala 
                85                  90                  95      


Ile Val Gly Val Gly Lys Gln Trp Ser Gly Ala Arg Ala Leu Glu Ala 
            100                 105                 110         


Leu Leu Thr Val Ala Gly Glu Leu Arg Gly Pro Pro Leu Gln Leu Asp 
        115                 120                 125             


Thr Gly Gln Leu Leu Lys Ile Ala Lys Arg Gly Gly Val Thr Ala Val 
    130                 135                 140                 


Glu Ala Val His Ala Trp Arg Asn Ala Leu Thr Gly Ala Pro Leu Asn 
145                 150                 155                 160 


Leu Thr Pro Glu Gln Val Val Ala Ile Ala Ser Asn Ile Gly Gly Lys 
                165                 170                 175     


Gln Ala Leu Glu Thr Val Gln Ala Leu Leu Pro Val Leu Cys Gln Ala 
            180                 185                 190         


His Gly Leu Thr Pro Glu Gln Val Val Ala Ile Ala Ser His Asp Gly 
        195                 200                 205             


Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu Leu Pro Val Leu Cys 
    210                 215                 220                 


Gln Ala His Gly Leu Thr Pro Glu Gln Val Val Ala Ile Ala Ser Asn 
225                 230                 235                 240 


Ile Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Ala Leu Leu Pro Val 
                245                 250                 255     


Leu Cys Gln Ala His Gly Leu Thr Pro Gln Gln Val Val Ala Ile Ala 
            260                 265                 270         


Ser Asn Asn Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu Leu 
        275                 280                 285             


Pro Val Leu Cys Gln Ala His Gly Leu Thr Pro Gln Gln Val Val Ala 
    290                 295                 300                 


Ile Ala Ser Asn Asn Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg 
305                 310                 315                 320 


Leu Leu Pro Val Leu Cys Gln Ala His Gly Leu Thr Pro Glu Gln Val 
                325                 330                 335     


Val Ala Ile Ala Ser Asn Ile Gly Gly Lys Gln Ala Leu Glu Thr Val 
            340                 345                 350         


Gln Ala Leu Leu Pro Val Leu Cys Gln Ala His Gly Leu Thr Pro Gln 
        355                 360                 365             


Gln Val Val Ala Ile Ala Ser Asn Asn Gly Gly Lys Gln Ala Leu Glu 
    370                 375                 380                 


Thr Val Gln Arg Leu Leu Pro Val Leu Cys Gln Ala His Gly Leu Thr 
385                 390                 395                 400 


Pro Gln Gln Val Val Ala Ile Ala Ser Asn Asn Gly Gly Lys Gln Ala 
                405                 410                 415     


Leu Glu Thr Val Gln Arg Leu Leu Pro Val Leu Cys Gln Ala His Gly 
            420                 425                 430         


Leu Thr Pro Glu Gln Val Val Ala Ile Ala Ser Asn Ile Gly Gly Lys 
        435                 440                 445             


Gln Ala Leu Glu Thr Val Gln Ala Leu Leu Pro Val Leu Cys Gln Ala 
    450                 455                 460                 


His Gly Leu Thr Pro Glu Gln Val Val Ala Ile Ala Ser Asn Ile Gly 
465                 470                 475                 480 


Gly Lys Gln Ala Leu Glu Thr Val Gln Ala Leu Leu Pro Val Leu Cys 
                485                 490                 495     


Gln Ala His Gly Leu Thr Pro Gln Gln Val Val Ala Ile Ala Ser Asn 
            500                 505                 510         


Asn Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu Leu Pro Val 
        515                 520                 525             


Leu Cys Gln Ala His Gly Leu Thr Pro Glu Gln Val Val Ala Ile Ala 
    530                 535                 540                 


Ser Asn Ile Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Ala Leu Leu 
545                 550                 555                 560 


Pro Val Leu Cys Gln Ala His Gly Leu Thr Pro Gln Gln Val Val Ala 
                565                 570                 575     


Ile Ala Ser Asn Asn Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg 
            580                 585                 590         


Leu Leu Pro Val Leu Cys Gln Ala His Gly Leu Thr Pro Gln Gln Val 
        595                 600                 605             


Val Ala Ile Ala Ser Asn Gly Gly Gly Lys Gln Ala Leu Glu Thr Val 
    610                 615                 620                 


Gln Arg Leu Leu Pro Val Leu Cys Gln Ala His Gly Leu Thr Pro Glu 
625                 630                 635                 640 


Gln Val Val Ala Ile Ala Ser Asn Ile Gly Gly Lys Gln Ala Leu Glu 
                645                 650                 655     


Thr Val Gln Ala Leu Leu Pro Val Leu Cys Gln Ala His Gly Leu Thr 
            660                 665                 670         


Pro Gln Gln Val Val Ala Ile Ala Ser Asn Gly Gly Gly Arg Pro Ala 
        675                 680                 685             


Leu Glu Ser Ile Val Ala Gln Leu Ser Arg Pro Asp Pro Ser Gly Ser 
    690                 695                 700                 


Gly Ser Gly Gly Asp Pro Ile Ser Arg Ser Gln Leu Val Lys Ser Glu 
705                 710                 715                 720 


Leu Glu Glu Lys Lys Ser Glu Leu Arg His Lys Leu Lys Tyr Val Pro 
                725                 730                 735     


His Glu Tyr Ile Glu Leu Ile Glu Ile Ala Arg Asn Ser Thr Gln Asp 
            740                 745                 750         


Arg Ile Leu Glu Met Lys Val Met Glu Phe Phe Met Lys Val Tyr Gly 
        755                 760                 765             


Tyr Arg Gly Lys His Leu Gly Gly Ser Arg Lys Pro Asp Gly Ala Ile 
    770                 775                 780                 


Tyr Thr Val Gly Ser Pro Ile Asp Tyr Gly Val Ile Val Asp Thr Lys 
785                 790                 795                 800 


Ala Tyr Ser Gly Gly Tyr Asn Leu Pro Ile Gly Gln Ala Asp Glu Met 
                805                 810                 815     


Gln Arg Tyr Val Glu Glu Asn Gln Thr Arg Asn Lys His Ile Asn Pro 
            820                 825                 830         


Asn Glu Trp Trp Lys Val Tyr Pro Ser Ser Val Thr Glu Phe Lys Phe 
        835                 840                 845             


Leu Phe Val Ser Gly His Phe Lys Gly Asn Tyr Lys Ala Gln Leu Thr 
    850                 855                 860                 


Arg Leu Asn His Ile Thr Asn Cys Asn Gly Ala Val Leu Ser Val Glu 
865                 870                 875                 880 


Glu Leu Leu Ile Gly Gly Glu Met Ile Lys Ala Gly Thr Leu Thr Leu 
                885                 890                 895     


Glu Glu Val Arg Arg Lys Phe Asn Asn Gly Glu Ile Asn Phe Ala Ala 
            900                 905                 910         


Asp 
    


<210>  20

<211>  936
<212>  PRT
<213>  artificial sequence

<220>
<223>  TALEN PD1

<400>  20
Met Gly Asp Pro Lys Lys Lys Arg Lys Val Ile Asp Tyr Pro Tyr Asp 
1               5                   10                  15      


Val Pro Asp Tyr Ala Ile Asp Ile Ala Asp Leu Arg Thr Leu Gly Tyr 
            20                  25                  30          


Ser Gln Gln Gln Gln Glu Lys Ile Lys Pro Lys Val Arg Ser Thr Val 
        35                  40                  45              


Ala Gln His His Glu Ala Leu Val Gly His Gly Phe Thr His Ala His 
    50                  55                  60                  


Ile Val Ala Leu Ser Gln His Pro Ala Ala Leu Gly Thr Val Ala Val 
65                  70                  75                  80  


Lys Tyr Gln Asp Met Ile Ala Ala Leu Pro Glu Ala Thr His Glu Ala 
                85                  90                  95      


Ile Val Gly Val Gly Lys Gln Trp Ser Gly Ala Arg Ala Leu Glu Ala 
            100                 105                 110         


Leu Leu Thr Val Ala Gly Glu Leu Arg Gly Pro Pro Leu Gln Leu Asp 
        115                 120                 125             


Thr Gly Gln Leu Leu Lys Ile Ala Lys Arg Gly Gly Val Thr Ala Val 
    130                 135                 140                 


Glu Ala Val His Ala Trp Arg Asn Ala Leu Thr Gly Ala Pro Leu Asn 
145                 150                 155                 160 


Leu Thr Pro Glu Gln Val Val Ala Ile Ala Ser Lys Leu Gly Gly Lys 
                165                 170                 175     


Gln Ala Leu Glu Thr Val Gln Ala Leu Leu Pro Val Leu Cys Gln Ala 
            180                 185                 190         


His Gly Leu Thr Pro Glu Gln Val Val Ala Ile Ala Ser His Asp Gly 
        195                 200                 205             


Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu Leu Pro Val Leu Cys 
    210                 215                 220                 


Gln Ala His Gly Leu Thr Pro Glu Gln Val Val Ala Ile Ala Ser His 
225                 230                 235                 240 


Asp Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu Leu Pro Val 
                245                 250                 255     


Leu Cys Gln Ala His Gly Leu Thr Pro Gln Gln Val Val Ala Ile Ala 
            260                 265                 270         


Ser Asn Gly Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu Leu 
        275                 280                 285             


Pro Val Leu Cys Gln Ala His Gly Leu Thr Pro Glu Gln Val Val Ala 
    290                 295                 300                 


Ile Ala Ser His Asp Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg 
305                 310                 315                 320 


Leu Leu Pro Val Leu Cys Gln Ala His Gly Leu Thr Pro Gln Gln Val 
                325                 330                 335     


Val Ala Ile Ala Ser Asn Gly Gly Gly Lys Gln Ala Leu Glu Thr Val 
            340                 345                 350         


Gln Arg Leu Leu Pro Val Leu Cys Gln Ala His Gly Leu Thr Pro Gln 
        355                 360                 365             


Gln Val Val Ala Ile Ala Ser Tyr Lys Gly Gly Lys Gln Ala Leu Glu 
    370                 375                 380                 


Thr Val Gln Arg Leu Leu Pro Val Leu Cys Gln Ala His Gly Leu Thr 
385                 390                 395                 400 


Pro Gln Gln Val Val Ala Ile Ala Ser Asn Gly Gly Gly Lys Gln Ala 
                405                 410                 415     


Leu Glu Thr Val Gln Arg Leu Leu Pro Val Leu Cys Gln Ala His Gly 
            420                 425                 430         


Leu Thr Pro Gln Gln Val Val Ala Ile Ala Ser Asn Asn Gly Gly Lys 
        435                 440                 445             


Gln Ala Leu Glu Thr Val Gln Arg Leu Leu Pro Val Leu Cys Gln Ala 
    450                 455                 460                 


His Gly Leu Thr Pro Gln Gln Val Val Ala Ile Ala Ser Asn Asn Gly 
465                 470                 475                 480 


Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu Leu Pro Val Leu Cys 
                485                 490                 495     


Gln Ala His Gly Leu Thr Pro Gln Gln Val Val Ala Ile Ala Ser Asn 
            500                 505                 510         


Asn Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu Leu Pro Val 
        515                 520                 525             


Leu Cys Gln Ala His Gly Leu Thr Pro Gln Gln Val Val Ala Ile Ala 
    530                 535                 540                 


Ser Asn Asn Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu Leu 
545                 550                 555                 560 


Pro Val Leu Cys Gln Ala His Gly Leu Thr Pro Glu Gln Val Val Ala 
                565                 570                 575     


Ile Ala Ser His Asp Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg 
            580                 585                 590         


Leu Leu Pro Val Leu Cys Gln Ala His Gly Leu Thr Pro Glu Gln Val 
        595                 600                 605             


Val Ala Ile Ala Ser His Asp Gly Gly Lys Gln Ala Leu Glu Thr Val 
    610                 615                 620                 


Gln Arg Leu Leu Pro Val Leu Cys Gln Ala His Gly Leu Thr Pro Glu 
625                 630                 635                 640 


Gln Val Val Ala Ile Ala Ser Asn Ile Gly Gly Lys Gln Ala Leu Glu 
                645                 650                 655     


Thr Val Gln Ala Leu Leu Pro Val Leu Cys Gln Ala His Gly Leu Thr 
            660                 665                 670         


Pro Gln Gln Val Val Ala Ile Ala Ser Asn Gly Gly Gly Arg Pro Ala 
        675                 680                 685             


Leu Glu Ser Ile Val Ala Gln Leu Ser Arg Pro Asp Pro Ala Leu Ala 
    690                 695                 700                 


Ala Leu Thr Asn Asp His Leu Val Ala Leu Ala Cys Leu Gly Gly Arg 
705                 710                 715                 720 


Pro Ala Leu Asp Ala Val Lys Lys Gly Leu Gly Asp Pro Ile Ser Arg 
                725                 730                 735     


Ser Gln Leu Val Lys Ser Glu Leu Glu Glu Lys Lys Ser Glu Leu Arg 
            740                 745                 750         


His Lys Leu Lys Tyr Val Pro His Glu Tyr Ile Glu Leu Ile Glu Ile 
        755                 760                 765             


Ala Arg Asn Ser Thr Gln Asp Arg Ile Leu Glu Met Lys Val Met Glu 
    770                 775                 780                 


Phe Phe Met Lys Val Tyr Gly Tyr Arg Gly Lys His Leu Gly Gly Ser 
785                 790                 795                 800 


Arg Lys Pro Asp Gly Ala Ile Tyr Thr Val Gly Ser Pro Ile Asp Tyr 
                805                 810                 815     


Gly Val Ile Val Asp Thr Lys Ala Tyr Ser Gly Gly Tyr Asn Leu Pro 
            820                 825                 830         


Ile Gly Gln Ala Asp Glu Met Gln Arg Tyr Val Glu Glu Asn Gln Thr 
        835                 840                 845             


Arg Asn Lys His Ile Asn Pro Asn Glu Trp Trp Lys Val Tyr Pro Ser 
    850                 855                 860                 


Ser Val Thr Glu Phe Lys Phe Leu Phe Val Ser Gly His Phe Lys Gly 
865                 870                 875                 880 


Asn Tyr Lys Ala Gln Leu Thr Arg Leu Asn His Ile Thr Asn Cys Asn 
                885                 890                 895     


Gly Ala Val Leu Ser Val Glu Glu Leu Leu Ile Gly Gly Glu Met Ile 
            900                 905                 910         


Lys Ala Gly Thr Leu Thr Leu Glu Glu Val Arg Arg Lys Phe Asn Asn 
        915                 920                 925             


Gly Glu Ile Asn Phe Ala Ala Asp 
    930                 935     


<210>  21

<211>  941
<212>  PRT
<213>  artificial sequence

<220>
<223>  TALEN PD1

<400>  21
Met Gly Asp Pro Lys Lys Lys Arg Lys Val Ile Asp Lys Glu Thr Ala 
1               5                   10                  15      


Ala Ala Lys Phe Glu Arg Gln His Met Asp Ser Ile Asp Ile Ala Asp 
            20                  25                  30          


Leu Arg Thr Leu Gly Tyr Ser Gln Gln Gln Gln Glu Lys Ile Lys Pro 
        35                  40                  45              


Lys Val Arg Ser Thr Val Ala Gln His His Glu Ala Leu Val Gly His 
    50                  55                  60                  


Gly Phe Thr His Ala His Ile Val Ala Leu Ser Gln His Pro Ala Ala 
65                  70                  75                  80  


Leu Gly Thr Val Ala Val Lys Tyr Gln Asp Met Ile Ala Ala Leu Pro 
                85                  90                  95      


Glu Ala Thr His Glu Ala Ile Val Gly Val Gly Lys Gln Trp Ser Gly 
            100                 105                 110         


Ala Arg Ala Leu Glu Ala Leu Leu Thr Val Ala Gly Glu Leu Arg Gly 
        115                 120                 125             


Pro Pro Leu Gln Leu Asp Thr Gly Gln Leu Leu Lys Ile Ala Lys Arg 
    130                 135                 140                 


Gly Gly Val Thr Ala Val Glu Ala Val His Ala Trp Arg Asn Ala Leu 
145                 150                 155                 160 


Thr Gly Ala Pro Leu Asn Leu Thr Pro Glu Gln Val Val Ala Ile Ala 
                165                 170                 175     


Ser His Asp Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu Leu 
            180                 185                 190         


Pro Val Leu Cys Gln Ala His Gly Leu Thr Pro Gln Gln Val Val Ala 
        195                 200                 205             


Ile Ala Ser Asn Gly Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg 
    210                 215                 220                 


Leu Leu Pro Val Leu Cys Gln Ala His Gly Leu Thr Pro Glu Gln Val 
225                 230                 235                 240 


Val Ala Ile Ala Ser His Asp Gly Gly Lys Gln Ala Leu Glu Thr Val 
                245                 250                 255     


Gln Arg Leu Leu Pro Val Leu Cys Gln Ala His Gly Leu Thr Pro Gln 
            260                 265                 270         


Gln Val Val Ala Ile Ala Ser Asn Gly Gly Gly Lys Gln Ala Leu Glu 
        275                 280                 285             


Thr Val Gln Arg Leu Leu Pro Val Leu Cys Gln Ala His Gly Leu Thr 
    290                 295                 300                 


Pro Gln Gln Val Val Ala Ile Ala Ser Asn Gly Gly Gly Lys Gln Ala 
305                 310                 315                 320 


Leu Glu Thr Val Gln Arg Leu Leu Pro Val Leu Cys Gln Ala His Gly 
                325                 330                 335     


Leu Thr Pro Gln Gln Val Val Ala Ile Ala Ser Asn Gly Gly Gly Lys 
            340                 345                 350         


Gln Ala Leu Glu Thr Val Gln Arg Leu Leu Pro Val Leu Cys Gln Ala 
        355                 360                 365             


His Gly Leu Thr Pro Gln Gln Val Val Ala Ile Ala Ser Asn Asn Gly 
    370                 375                 380                 


Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu Leu Pro Val Leu Cys 
385                 390                 395                 400 


Gln Ala His Gly Leu Thr Pro Glu Gln Val Val Ala Ile Ala Ser Asn 
                405                 410                 415     


Ile Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Ala Leu Leu Pro Val 
            420                 425                 430         


Leu Cys Gln Ala His Gly Leu Thr Pro Gln Gln Val Val Ala Ile Ala 
        435                 440                 445             


Ser Asn Gly Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu Leu 
    450                 455                 460                 


Pro Val Leu Cys Gln Ala His Gly Leu Thr Pro Glu Gln Val Val Ala 
465                 470                 475                 480 


Ile Ala Ser His Asp Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg 
                485                 490                 495     


Leu Leu Pro Val Leu Cys Gln Ala His Gly Leu Thr Pro Gln Gln Val 
            500                 505                 510         


Val Ala Ile Ala Ser Asn Gly Gly Gly Lys Gln Ala Leu Glu Thr Val 
        515                 520                 525             


Gln Arg Leu Leu Pro Val Leu Cys Gln Ala His Gly Leu Thr Pro Gln 
    530                 535                 540                 


Gln Val Val Ala Ile Ala Ser Asn Asn Gly Gly Lys Gln Ala Leu Glu 
545                 550                 555                 560 


Thr Val Gln Arg Leu Leu Pro Val Leu Cys Gln Ala His Gly Leu Thr 
                565                 570                 575     


Pro Glu Gln Val Val Ala Ile Ala Ser Asn Gly Gly Lys Gln Ala Leu 
            580                 585                 590         


Glu Thr Val Gln Arg Leu Leu Pro Val Leu Cys Gln Ala His Gly Leu 
        595                 600                 605             


Thr Pro Gln Gln Val Val Ala Ile Ala Ser Asn Asn Gly Gly Lys Gln 
    610                 615                 620                 


Ala Leu Glu Thr Val Gln Arg Leu Leu Pro Val Leu Cys Gln Ala His 
625                 630                 635                 640 


Gly Leu Thr Pro Glu Gln Val Val Ala Ile Ala Ser His Asp Gly Gly 
                645                 650                 655     


Lys Gln Ala Leu Glu Thr Val Gln Arg Leu Leu Pro Val Leu Cys Gln 
            660                 665                 670         


Ala His Gly Leu Thr Pro Gln Gln Val Val Ala Ile Ala Ser Asn Gly 
        675                 680                 685             


Gly Gly Arg Pro Ala Leu Glu Ser Ile Val Ala Gln Leu Ser Arg Pro 
    690                 695                 700                 


Asp Pro Ala Leu Ala Ala Leu Thr Asn Asp His Leu Val Ala Leu Ala 
705                 710                 715                 720 


Cys Leu Gly Gly Arg Pro Ala Leu Asp Ala Val Lys Lys Gly Leu Gly 
                725                 730                 735     


Asp Pro Ile Ser Arg Ser Gln Leu Val Lys Ser Glu Leu Glu Glu Lys 
            740                 745                 750         


Lys Ser Glu Leu Arg His Lys Leu Lys Tyr Val Pro His Glu Tyr Ile 
        755                 760                 765             


Glu Leu Ile Glu Ile Ala Arg Asn Ser Thr Gln Asp Arg Ile Leu Glu 
    770                 775                 780                 


Met Lys Val Met Glu Phe Phe Met Lys Val Tyr Gly Tyr Arg Gly Lys 
785                 790                 795                 800 


His Leu Gly Gly Ser Arg Lys Pro Asp Gly Ala Ile Tyr Thr Val Gly 
                805                 810                 815     


Ser Pro Ile Asp Tyr Gly Val Ile Val Asp Thr Lys Ala Tyr Ser Gly 
            820                 825                 830         


Gly Tyr Asn Leu Pro Ile Gly Gln Ala Asp Glu Met Gln Arg Tyr Val 
        835                 840                 845             


Glu Glu Asn Gln Thr Arg Asn Lys His Ile Asn Pro Asn Glu Trp Trp 
    850                 855                 860                 


Lys Val Tyr Pro Ser Ser Val Thr Glu Phe Lys Phe Leu Phe Val Ser 
865                 870                 875                 880 


Gly His Phe Lys Gly Asn Tyr Lys Ala Gln Leu Thr Arg Leu Asn His 
                885                 890                 895     


Ile Thr Asn Cys Asn Gly Ala Val Leu Ser Val Glu Glu Leu Leu Ile 
            900                 905                 910         


Gly Gly Glu Met Ile Lys Ala Gly Thr Leu Thr Leu Glu Glu Val Arg 
        915                 920                 925             


Arg Lys Phe Asn Asn Gly Glu Ile Asn Phe Ala Ala Asp 
    930                 935                 940     



<210>  22

<211>  2814
<212>  DNA
<213>  artificial sequence

<220>
<223>  TALEN TRAC pCLS11370

<400>  22
atgggcgatc ctaaaaagaa acgtaaggtc atcgattacc catacgatgt tccagattac     60
gctatcgata tcgccgatct acgcacgctc ggctacagcc agcagcaaca ggagaagatc    120
aaaccgaagg ttcgttcgac agtggcgcag caccacgagg cactggtcgg ccacgggttt    180
acacacgcgc acatcgttgc gttaagccaa cacccggcag cgttagggac cgtcgctgtc    240
aagtatcagg acatgatcgc agcgttgcca gaggcgacac acgaagcgat cgttggcgtc    300
ggcaaacagt ggtccggcgc acgcgctctg gaggccttgc tcacggtggc gggagagttg    360
agaggtccac cgttacagtt ggacacaggc caacttctca agattgcaaa acgtggcggc    420
gtgaccgcag tggaggcagt gcatgcatgg cgcaatgcac tgacgggtgc cccgctcaac    480
ttgacccccc agcaggtggt ggccatcgcc agcaatggcg gtggcaagca ggcgctggag    540
acggtccagc ggctgttgcc ggtgctgtgc caggcccacg gcttgacccc ccagcaggtg    600
gtggccatcg ccagcaataa tggtggcaag caggcgctgg agacggtcca gcggctgttg    660
ccggtgctgt gccaggccca cggcttgacc ccccagcagg tggtggccat cgccagcaat    720
ggcggtggca agcaggcgct ggagacggtc cagcggctgt tgccggtgct gtgccaggcc    780
cacggcttga ccccggagca ggtggtggcc atcgccagcc acgatggcgg caagcaggcg    840
ctggagacgg tccagcggct gttgccggtg ctgtgccagg cccacggctt gaccccggag    900
caggtggtgg ccatcgccag ccacgatggc ggcaagcagg cgctggagac ggtccagcgg    960
ctgttgccgg tgctgtgcca ggcccacggc ttgaccccgg agcaggtggt ggccatcgcc   1020
agccacgatg gcggcaagca ggcgctggag acggtccagc ggctgttgcc ggtgctgtgc   1080
caggcccacg gcttgacccc ggagcaggtg gtggccatcg ccagcaatat tggtggcaag   1140
caggcgctgg agacggtgca ggcgctgttg ccggtgctgt gccaggccca cggcttgacc   1200
ccggagcagg tggtggccat cgccagccac gatggcggca agcaggcgct ggagacggtc   1260
cagcggctgt tgccggtgct gtgccaggcc cacggcttga ccccggagca ggtggtggcc   1320
atcgccagca atattggtgg caagcaggcg ctggagacgg tgcaggcgct gttgccggtg   1380
ctgtgccagg cccacggctt gaccccccag caggtggtgg ccatcgccag caataatggt   1440
ggcaagcagg cgctggagac ggtccagcgg ctgttgccgg tgctgtgcca ggcccacggc   1500
ttgaccccgg agcaggtggt ggccatcgcc agcaatattg gtggcaagca ggcgctggag   1560
acggtgcagg cgctgttgcc ggtgctgtgc caggcccacg gcttgacccc ccagcaggtg   1620
gtggccatcg ccagcaatgg cggtggcaag caggcgctgg agacggtcca gcggctgttg   1680
ccggtgctgt gccaggccca cggcttgacc ccggagcagg tggtggccat cgccagcaat   1740
attggtggca agcaggcgct ggagacggtg caggcgctgt tgccggtgct gtgccaggcc   1800
cacggcttga ccccccagca ggtggtggcc atcgccagca atggcggtgg caagcaggcg   1860
ctggagacgg tccagcggct gttgccggtg ctgtgccagg cccacggctt gaccccggag   1920
caggtggtgg ccatcgccag ccacgatggc ggcaagcagg cgctggagac ggtccagcgg   1980
ctgttgccgg tgctgtgcca ggcccacggc ttgacccctc agcaggtggt ggccatcgcc   2040
agcaatggcg gcggcaggcc ggcgctggag agcattgttg cccagttatc tcgccctgat   2100
ccggcgttgg ccgcgttgac caacgaccac ctcgtcgcct tggcctgcct cggcgggcgt   2160
cctgcgctgg atgcagtgaa aaagggattg ggggatccta tcagccgttc ccagctggtg   2220
aagtccgagc tggaggagaa gaaatccgag ttgaggcaca agctgaagta cgtgccccac   2280
gagtacatcg agctgatcga gatcgcccgg aacagcaccc aggaccgtat cctggagatg   2340
aaggtgatgg agttcttcat gaaggtgtac ggctacaggg gcaagcacct gggcggctcc   2400
aggaagcccg acggcgccat ctacaccgtg ggctccccca tcgactacgg cgtgatcgtg   2460
gacaccaagg cctactccgg cggctacaac ctgcccatcg gccaggccga cgaaatgcag   2520
aggtacgtgg aggagaacca gaccaggaac aagcacatca accccaacga gtggtggaag   2580
gtgtacccct ccagcgtgac cgagttcaag ttcctgttcg tgtccggcca cttcaagggc   2640
aactacaagg cccagctgac caggctgaac cacatcacca actgcaacgg cgccgtgctg   2700
tccgtggagg agctcctgat cggcggcgag atgatcaagg ccggcaccct gaccctggag   2760
gaggtgagga ggaagttcaa caacggcgag atcaacttcg cggccgactg ataa         2814


<210>  23

<211>  2832
<212>  DNA
<213>  artificial sequence

<220>
<223>  TALEN TRAC pCLS11369

<400>  23
atgggcgatc ctaaaaagaa acgtaaggtc atcgataagg agaccgccgc tgccaagttc     60
gagagacagc acatggacag catcgatatc gccgatctac gcacgctcgg ctacagccag    120
cagcaacagg agaagatcaa accgaaggtt cgttcgacag tggcgcagca ccacgaggca    180
ctggtcggcc acgggtttac acacgcgcac atcgttgcgt taagccaaca cccggcagcg    240
ttagggaccg tcgctgtcaa gtatcaggac atgatcgcag cgttgccaga ggcgacacac    300
gaagcgatcg ttggcgtcgg caaacagtgg tccggcgcac gcgctctgga ggccttgctc    360
acggtggcgg gagagttgag aggtccaccg ttacagttgg acacaggcca acttctcaag    420
attgcaaaac gtggcggcgt gaccgcagtg gaggcagtgc atgcatggcg caatgcactg    480
acgggtgccc cgctcaactt gaccccggag caggtggtgg ccatcgccag ccacgatggc    540
ggcaagcagg cgctggagac ggtccagcgg ctgttgccgg tgctgtgcca ggcccacggc    600
ttgacccccc agcaggtggt ggccatcgcc agcaatggcg gtggcaagca ggcgctggag    660
acggtccagc ggctgttgcc ggtgctgtgc caggcccacg gcttgacccc ggagcaggtg    720
gtggccatcg ccagccacga tggcggcaag caggcgctgg agacggtcca gcggctgttg    780
ccggtgctgt gccaggccca cggcttgacc ccggagcagg tggtggccat cgccagcaat    840
attggtggca agcaggcgct ggagacggtg caggcgctgt tgccggtgct gtgccaggcc    900
cacggcttga ccccccagca ggtggtggcc atcgccagca ataatggtgg caagcaggcg    960
ctggagacgg tccagcggct gttgccggtg ctgtgccagg cccacggctt gaccccggag   1020
caggtggtgg ccatcgccag ccacgatggc ggcaagcagg cgctggagac ggtccagcgg   1080
ctgttgccgg tgctgtgcca ggcccacggc ttgacccccc agcaggtggt ggccatcgcc   1140
agcaatggcg gtggcaagca ggcgctggag acggtccagc ggctgttgcc ggtgctgtgc   1200
caggcccacg gcttgacccc ccagcaggtg gtggccatcg ccagcaataa tggtggcaag   1260
caggcgctgg agacggtcca gcggctgttg ccggtgctgt gccaggccca cggcttgacc   1320
ccccagcagg tggtggccat cgccagcaat aatggtggca agcaggcgct ggagacggtc   1380
cagcggctgt tgccggtgct gtgccaggcc cacggcttga ccccccagca ggtggtggcc   1440
atcgccagca atggcggtgg caagcaggcg ctggagacgg tccagcggct gttgccggtg   1500
ctgtgccagg cccacggctt gaccccggag caggtggtgg ccatcgccag caatattggt   1560
ggcaagcagg cgctggagac ggtgcaggcg ctgttgccgg tgctgtgcca ggcccacggc   1620
ttgaccccgg agcaggtggt ggccatcgcc agccacgatg gcggcaagca ggcgctggag   1680
acggtccagc ggctgttgcc ggtgctgtgc caggcccacg gcttgacccc ggagcaggtg   1740
gtggccatcg ccagcaatat tggtggcaag caggcgctgg agacggtgca ggcgctgttg   1800
ccggtgctgt gccaggccca cggcttgacc ccggagcagg tggtggccat cgccagccac   1860
gatggcggca agcaggcgct ggagacggtc cagcggctgt tgccggtgct gtgccaggcc   1920
cacggcttga ccccccagca ggtggtggcc atcgccagca ataatggtgg caagcaggcg   1980
ctggagacgg tccagcggct gttgccggtg ctgtgccagg cccacggctt gacccctcag   2040
caggtggtgg ccatcgccag caatggcggc ggcaggccgg cgctggagag cattgttgcc   2100
cagttatctc gccctgatcc ggcgttggcc gcgttgacca acgaccacct cgtcgccttg   2160
gcctgcctcg gcgggcgtcc tgcgctggat gcagtgaaaa agggattggg ggatcctatc   2220
agccgttccc agctggtgaa gtccgagctg gaggagaaga aatccgagtt gaggcacaag   2280
ctgaagtacg tgccccacga gtacatcgag ctgatcgaga tcgcccggaa cagcacccag   2340
gaccgtatcc tggagatgaa ggtgatggag ttcttcatga aggtgtacgg ctacaggggc   2400
aagcacctgg gcggctccag gaagcccgac ggcgccatct acaccgtggg ctcccccatc   2460
gactacggcg tgatcgtgga caccaaggcc tactccggcg gctacaacct gcccatcggc   2520
caggccgacg aaatgcagag gtacgtggag gagaaccaga ccaggaacaa gcacatcaac   2580
cccaacgagt ggtggaaggt gtacccctcc agcgtgaccg agttcaagtt cctgttcgtg   2640
tccggccact tcaagggcaa ctacaaggcc cagctgacca ggctgaacca catcaccaac   2700
tgcaacggcg ccgtgctgtc cgtggaggag ctcctgatcg gcggcgagat gatcaaggcc   2760
ggcaccctga ccctggagga ggtgaggagg aagttcaaca acggcgagat caacttcgcg   2820
gccgactgat aa                                                       2832


<210>  24

<211>  2745
<212>  DNA
<213>  artificial sequence

<220>
<223>  TALEN CD25 pCLS30480

<400>  24
atgggcgatc ctaaaaagaa acgtaaggtc atcgattacc catacgatgt tccagattac     60
gctatcgata tcgccgatct acgcacgctc ggctacagcc agcagcaaca ggagaagatc    120
aaaccgaagg ttcgttcgac agtggcgcag caccacgagg cactggtcgg ccacgggttt    180
acacacgcgc acatcgttgc gttaagccaa cacccggcag cgttagggac cgtcgctgtc    240
aagtatcagg acatgatcgc agcgttgcca gaggcgacac acgaagcgat cgttggcgtc    300
ggcaaacagt ggtccggcgc acgcgctctg gaggccttgc tcacggtggc gggagagttg    360
agaggtccac cgttacagtt ggacacaggc caacttctca agattgcaaa acgtggcggc    420
gtgaccgcag tggaggcagt gcatgcatgg cgcaatgcac tgacgggtgc cccgctcaac    480
ttgacccccc agcaggtggt ggccatcgcc agcaataatg gtggcaagca ggcgctggag    540
acggtccagc ggctgttgcc ggtgctgtgc caggcccacg gcttgacccc ccagcaggtg    600
gtggccatcg ccagcaatgg cggtggcaag caggcgctgg agacggtcca gcggctgttg    660
ccggtgctgt gccaggccca cggcttgacc ccccagcagg tggtggccat cgccagcaat    720
ggcggtggca agcaggcgct ggagacggtc cagcggctgt tgccggtgct gtgccaggcc    780
cacggcttga ccccggagca ggtggtggcc atcgccagcc acgatggcgg caagcaggcg    840
ctggagacgg tccagcggct gttgccggtg ctgtgccagg cccacggctt gaccccccag    900
caggtggtgg ccatcgccag caatggcggt ggcaagcagg cgctggagac ggtccagcgg    960
ctgttgccgg tgctgtgcca ggcccacggc ttgacccccc agcaggtggt ggccatcgcc   1020
agcaatggcg gtggcaagca ggcgctggag acggtccagc ggctgttgcc ggtgctgtgc   1080
caggcccacg gcttgacccc ccagcaggtg gtggccatcg ccagcaatgg cggtggcaag   1140
caggcgctgg agacggtcca gcggctgttg ccggtgctgt gccaggccca cggcttgacc   1200
ccccagcagg tggtggccat cgccagcaat ggcggtggca agcaggcgct ggagacggtc   1260
cagcggctgt tgccggtgct gtgccaggcc cacggcttga ccccccagca ggtggtggcc   1320
atcgccagca ataatggtgg caagcaggcg ctggagacgg tccagcggct gttgccggtg   1380
ctgtgccagg cccacggctt gaccccccag caggtggtgg ccatcgccag caataatggt   1440
ggcaagcagg cgctggagac ggtccagcgg ctgttgccgg tgctgtgcca ggcccacggc   1500
ttgacccccc agcaggtggt ggccatcgcc agcaatggcg gtggcaagca ggcgctggag   1560
acggtccagc ggctgttgcc ggtgctgtgc caggcccacg gcttgacccc ccagcaggtg   1620
gtggccatcg ccagcaatgg cggtggcaag caggcgctgg agacggtcca gcggctgttg   1680
ccggtgctgt gccaggccca cggcttgacc ccccagcagg tggtggccat cgccagcaat   1740
ggcggtggca agcaggcgct ggagacggtc cagcggctgt tgccggtgct gtgccaggcc   1800
cacggcttga ccccccagca ggtggtggcc atcgccagca atggcggtgg caagcaggcg   1860
ctggagacgg tccagcggct gttgccggtg ctgtgccagg cccacggctt gaccccggag   1920
caggtggtgg ccatcgccag ccacgatggc ggcaagcagg cgctggagac ggtccagcgg   1980
ctgttgccgg tgctgtgcca ggcccacggc ttgacccctc agcaggtggt ggccatcgcc   2040
agcaatggcg gcggcaggcc ggcgctggag agcattgttg cccagttatc tcgccctgat   2100
ccgagtggca gcggaagtgg cggggatcct atcagccgtt cccagctggt gaagtccgag   2160
ctggaggaga agaaatccga gttgaggcac aagctgaagt acgtgcccca cgagtacatc   2220
gagctgatcg agatcgcccg gaacagcacc caggaccgta tcctggagat gaaggtgatg   2280
gagttcttca tgaaggtgta cggctacagg ggcaagcacc tgggcggctc caggaagccc   2340
gacggcgcca tctacaccgt gggctccccc atcgactacg gcgtgatcgt ggacaccaag   2400
gcctactccg gcggctacaa cctgcccatc ggccaggccg acgaaatgca gaggtacgtg   2460
gaggagaacc agaccaggaa caagcacatc aaccccaacg agtggtggaa ggtgtacccc   2520
tccagcgtga ccgagttcaa gttcctgttc gtgtccggcc acttcaaggg caactacaag   2580
gcccagctga ccaggctgaa ccacatcacc aactgcaacg gcgccgtgct gtccgtggag   2640
gagctcctga tcggcggcga gatgatcaag gccggcaccc tgaccctgga ggaggtgagg   2700
aggaagttca acaacggcga gatcaacttc gcggccgact gataa                   2745


<210>  25

<211>  2745
<212>  DNA
<213>  artificial sequence

<220>
<223>  TALEN CD25 pCLS30479

<400>  25
atgggcgatc ctaaaaagaa acgtaaggtc atcgattacc catacgatgt tccagattac     60
gctatcgata tcgccgatct acgcacgctc ggctacagcc agcagcaaca ggagaagatc    120
aaaccgaagg ttcgttcgac agtggcgcag caccacgagg cactggtcgg ccacgggttt    180
acacacgcgc acatcgttgc gttaagccaa cacccggcag cgttagggac cgtcgctgtc    240
aagtatcagg acatgatcgc agcgttgcca gaggcgacac acgaagcgat cgttggcgtc    300
ggcaaacagt ggtccggcgc acgcgctctg gaggccttgc tcacggtggc gggagagttg    360
agaggtccac cgttacagtt ggacacaggc caacttctca agattgcaaa acgtggcggc    420
gtgaccgcag tggaggcagt gcatgcatgg cgcaatgcac tgacgggtgc cccgctcaac    480
ttgaccccgg agcaggtggt ggccatcgcc agcaatattg gtggcaagca ggcgctggag    540
acggtgcagg cgctgttgcc ggtgctgtgc caggcccacg gcttgacccc ggagcaggtg    600
gtggccatcg ccagccacga tggcggcaag caggcgctgg agacggtcca gcggctgttg    660
ccggtgctgt gccaggccca cggcttgacc ccggagcagg tggtggccat cgccagcaat    720
attggtggca agcaggcgct ggagacggtg caggcgctgt tgccggtgct gtgccaggcc    780
cacggcttga ccccccagca ggtggtggcc atcgccagca ataatggtgg caagcaggcg    840
ctggagacgg tccagcggct gttgccggtg ctgtgccagg cccacggctt gaccccccag    900
caggtggtgg ccatcgccag caataatggt ggcaagcagg cgctggagac ggtccagcgg    960
ctgttgccgg tgctgtgcca ggcccacggc ttgaccccgg agcaggtggt ggccatcgcc   1020
agcaatattg gtggcaagca ggcgctggag acggtgcagg cgctgttgcc ggtgctgtgc   1080
caggcccacg gcttgacccc ccagcaggtg gtggccatcg ccagcaataa tggtggcaag   1140
caggcgctgg agacggtcca gcggctgttg ccggtgctgt gccaggccca cggcttgacc   1200
ccccagcagg tggtggccat cgccagcaat aatggtggca agcaggcgct ggagacggtc   1260
cagcggctgt tgccggtgct gtgccaggcc cacggcttga ccccggagca ggtggtggcc   1320
atcgccagca atattggtgg caagcaggcg ctggagacgg tgcaggcgct gttgccggtg   1380
ctgtgccagg cccacggctt gaccccggag caggtggtgg ccatcgccag caatattggt   1440
ggcaagcagg cgctggagac ggtgcaggcg ctgttgccgg tgctgtgcca ggcccacggc   1500
ttgacccccc agcaggtggt ggccatcgcc agcaataatg gtggcaagca ggcgctggag   1560
acggtccagc ggctgttgcc ggtgctgtgc caggcccacg gcttgacccc ggagcaggtg   1620
gtggccatcg ccagcaatat tggtggcaag caggcgctgg agacggtgca ggcgctgttg   1680
ccggtgctgt gccaggccca cggcttgacc ccccagcagg tggtggccat cgccagcaat   1740
aatggtggca agcaggcgct ggagacggtc cagcggctgt tgccggtgct gtgccaggcc   1800
cacggcttga ccccccagca ggtggtggcc atcgccagca atggcggtgg caagcaggcg   1860
ctggagacgg tccagcggct gttgccggtg ctgtgccagg cccacggctt gaccccggag   1920
caggtggtgg ccatcgccag caatattggt ggcaagcagg cgctggagac ggtgcaggcg   1980
ctgttgccgg tgctgtgcca ggcccacggc ttgacccctc agcaggtggt ggccatcgcc   2040
agcaatggcg gcggcaggcc ggcgctggag agcattgttg cccagttatc tcgccctgat   2100
ccgagtggca gcggaagtgg cggggatcct atcagccgtt cccagctggt gaagtccgag   2160
ctggaggaga agaaatccga gttgaggcac aagctgaagt acgtgcccca cgagtacatc   2220
gagctgatcg agatcgcccg gaacagcacc caggaccgta tcctggagat gaaggtgatg   2280
gagttcttca tgaaggtgta cggctacagg ggcaagcacc tgggcggctc caggaagccc   2340
gacggcgcca tctacaccgt gggctccccc atcgactacg gcgtgatcgt ggacaccaag   2400
gcctactccg gcggctacaa cctgcccatc ggccaggccg acgaaatgca gaggtacgtg   2460
gaggagaacc agaccaggaa caagcacatc aaccccaacg agtggtggaa ggtgtacccc   2520
tccagcgtga ccgagttcaa gttcctgttc gtgtccggcc acttcaaggg caactacaag   2580
gcccagctga ccaggctgaa ccacatcacc aactgcaacg gcgccgtgct gtccgtggag   2640
gagctcctga tcggcggcga gatgatcaag gccggcaccc tgaccctgga ggaggtgagg   2700
aggaagttca acaacggcga gatcaacttc gcggccgact gataa                   2745


<210>  26

<211>  2814
<212>  DNA
<213>  artificial sequence

<220>
<223>  TALEN PD1 pCLS28959

<400>  26
atgggcgatc ctaaaaagaa acgtaaggtc atcgattacc catacgatgt tccagattac     60
gctatcgata tcgccgatct acgcacgctc ggctacagcc agcagcaaca ggagaagatc    120
aaaccgaagg ttcgttcgac agtggcgcag caccacgagg cactggtcgg ccacgggttt    180
acacacgcgc acatcgttgc gttaagccaa cacccggcag cgttagggac cgtcgctgtc    240
aagtatcagg acatgatcgc agcgttgcca gaggcgacac acgaagcgat cgttggcgtc    300
ggcaaacagt ggtccggcgc acgcgctctg gaggccttgc tcacggtggc gggagagttg    360
agaggtccac cgttacagtt ggacacaggc caacttctca agattgcaaa acgtggcggc    420
gtgaccgcag tggaggcagt gcatgcatgg cgcaatgcac tgacgggtgc cccgctcaac    480
ttgacccccg agcaagtggt ggctatcgct tccaagctgg ggggaaagca ggccctggag    540
accgtccagg cccttctccc agtgctttgc caggctcacg gactgacccc tgaacaggtg    600
gtggcaattg cctcacacga cgggggcaag caggcactgg agactgtcca gcggctgctg    660
cctgtcctct gccaggccca cggactcact cctgagcagg tcgtggccat tgccagccac    720
gatgggggca aacaggctct ggagaccgtg cagcgcctcc tcccagtgct gtgccaggct    780
catgggctga ccccacagca ggtcgtcgcc attgccagta acggcggggg gaagcaggcc    840
ctcgaaacag tgcagaggct gctgcccgtc ttgtgccaag cacacggcct gacacccgag    900
caggtggtgg ccatcgcctc tcatgacggc ggcaagcagg cccttgagac agtgcagaga    960
ctgttgcccg tgttgtgtca ggcccacggg ttgacacccc agcaggtggt cgccatcgcc   1020
agcaatggcg ggggaaagca ggcccttgag accgtgcagc ggttgcttcc agtgttgtgc   1080
caggcacacg gactgacccc tcaacaggtg gtcgcaatcg ccagctacaa gggcggaaag   1140
caggctctgg agacagtgca gcgcctcctg cccgtgctgt gtcaggctca cggactgaca   1200
ccacagcagg tggtcgccat cgccagtaac gggggcggca agcaggcttt ggagaccgtc   1260
cagagactcc tccccgtcct ttgccaggcc cacgggttga cacctcagca ggtcgtcgcc   1320
attgcctcca acaacggggg caagcaggcc ctcgaaactg tgcagaggct gctgcctgtg   1380
ctgtgccagg ctcatgggct gacaccccag caggtggtgg ccattgcctc taacaacggc   1440
ggcaaacagg cactggagac cgtgcaaagg ctgctgcccg tcctctgcca agcccacggg   1500
ctcactccac agcaggtcgt ggccatcgcc tcaaacaatg gcgggaagca ggccctggag   1560
actgtgcaaa ggctgctccc tgtgctctgc caggcacacg gactgacccc tcagcaggtg   1620
gtggcaatcg cttccaacaa cgggggaaag caggccctcg aaaccgtgca gcgcctcctc   1680
ccagtgctgt gccaggcaca tggcctcaca cccgagcaag tggtggctat cgccagccac   1740
gacggaggga agcaggctct ggagaccgtg cagaggctgc tgcctgtcct gtgccaggcc   1800
cacgggctta ctccagagca ggtcgtcgcc atcgccagtc atgatggggg gaagcaggcc   1860
cttgagacag tccagcggct gctgccagtc ctttgccagg ctcacggctt gactcccgag   1920
caggtcgtgg ccattgcctc aaacattggg ggcaaacagg ccctggagac agtgcaggcc   1980
ctgctgcccg tgttgtgtca ggcccacggc ttgacacccc agcaggtggt cgccattgcc   2040
tctaatggcg gcgggagacc cgccttggag agcattgttg cccagttatc tcgccctgat   2100
ccggcgttgg ccgcgttgac caacgaccac ctcgtcgcct tggcctgcct cggcgggcgt   2160
cctgcgctgg atgcagtgaa aaagggattg ggggatccta tcagccgttc ccagctggtg   2220
aagtccgagc tggaggagaa gaaatccgag ttgaggcaca agctgaagta cgtgccccac   2280
gagtacatcg agctgatcga gatcgcccgg aacagcaccc aggaccgtat cctggagatg   2340
aaggtgatgg agttcttcat gaaggtgtac ggctacaggg gcaagcacct gggcggctcc   2400
aggaagcccg acggcgccat ctacaccgtg ggctccccca tcgactacgg cgtgatcgtg   2460
gacaccaagg cctactccgg cggctacaac ctgcccatcg gccaggccga cgaaatgcag   2520
aggtacgtgg aggagaacca gaccaggaac aagcacatca accccaacga gtggtggaag   2580
gtgtacccct ccagcgtgac cgagttcaag ttcctgttcg tgtccggcca cttcaagggc   2640
aactacaagg cccagctgac caggctgaac cacatcacca actgcaacgg cgccgtgctg   2700
tccgtggagg agctcctgat cggcggcgag atgatcaagg ccggcaccct gaccctggag   2760
gaggtgagga ggaagttcaa caacggcgag atcaacttcg cggccgactg ataa         2814


<210>  27

<211>  2829
<212>  DNA
<213>  artificial sequence

<220>
<223>  TALEN PD1 pCLS18792

<400>  27
atgggcgatc ctaaaaagaa acgtaaggtc atcgataagg agaccgccgc tgccaagttc     60
gagagacagc acatggacag catcgatatc gccgatctac gcacgctcgg ctacagccag    120
cagcaacagg agaagatcaa accgaaggtt cgttcgacag tggcgcagca ccacgaggca    180
ctggtcggcc acgggtttac acacgcgcac atcgttgcgt taagccaaca cccggcagcg    240
ttagggaccg tcgctgtcaa gtatcaggac atgatcgcag cgttgccaga ggcgacacac    300
gaagcgatcg ttggcgtcgg caaacagtgg tccggcgcac gcgctctgga ggccttgctc    360
acggtggcgg gagagttgag aggtccaccg ttacagttgg acacaggcca acttctcaag    420
attgcaaaac gtggcggcgt gaccgcagtg gaggcagtgc atgcatggcg caatgcactg    480
acgggtgccc cgctcaactt gacccccgag caagtcgtcg caatcgccag ccatgatgga    540
gggaagcaag ccctcgaaac cgtgcagcgg ttgcttcctg tgctctgcca ggcccacggc    600
cttacccctc agcaggtggt ggccatcgca agtaacggag gaggaaagca agccttggag    660
acagtgcagc gcctgttgcc cgtgctgtgc caggcacacg gcctcacacc agagcaggtc    720
gtggccattg cctcccatga cggggggaaa caggctctgg agaccgtcca gaggctgctg    780
cccgtcctct gtcaagctca cggcctgact ccccaacaag tggtcgccat cgcctctaat    840
ggcggcggga agcaggcact ggaaacagtg cagagactgc tccctgtgct ttgccaagct    900
catgggttga ccccccaaca ggtcgtcgct attgcctcaa acgggggggg caagcaggcc    960
cttgagactg tgcagaggct gttgccagtg ctgtgtcagg ctcacgggct cactccacaa   1020
caggtggtcg caattgccag caacggcggc ggaaagcaag ctcttgaaac cgtgcaacgc   1080
ctcctgcccg tgctctgtca ggctcatggc ctgacaccac aacaagtcgt ggccatcgcc   1140
agtaataatg gcgggaaaca ggctcttgag accgtccaga ggctgctccc agtgctctgc   1200
caggcacacg ggctgacccc cgagcaggtg gtggctatcg ccagcaatat tgggggcaag   1260
caggccctgg aaacagtcca ggccctgctg ccagtgcttt gccaggctca cgggctcact   1320
ccccagcagg tcgtggcaat cgcctccaac ggcggaggga agcaggctct ggagaccgtg   1380
cagagactgc tgcccgtctt gtgccaggcc cacggactca cacctgaaca ggtcgtcgcc   1440
attgcctctc acgatggggg caaacaagcc ctggagacag tgcagcggct gttgcctgtg   1500
ttgtgccaag cccacggctt gactcctcaa caagtggtcg ccatcgcctc aaatggcggc   1560
ggaaaacaag ctctggagac agtgcagagg ttgctgcccg tcctctgcca agcccacggc   1620
ctgactcccc aacaggtcgt cgccattgcc agcaacaacg gaggaaagca ggctctcgaa   1680
actgtgcagc ggctgcttcc tgtgctgtgt caggctcatg ggctgacccc cgagcaagtg   1740
gtggctattg cctctaatgg aggcaagcaa gcccttgaga cagtccagag gctgttgcca   1800
gtgctgtgcc aggcccacgg gctcacaccc cagcaggtgg tcgccatcgc cagtaacaac   1860
gggggcaaac aggcattgga aaccgtccag cgcctgcttc cagtgctctg ccaggcacac   1920
ggactgacac ccgaacaggt ggtggccatt gcatcccatg atgggggcaa gcaggccctg   1980
gagaccgtgc agagactcct gccagtgttg tgccaagctc acggcctcac ccctcagcaa   2040
gtcgtggcca tcgcctcaaa cggggggggc cggcctgcac tggagagcat tgttgcccag   2100
ttatctcgcc ctgatccggc gttggccgcg ttgaccaacg accacctcgt cgccttggcc   2160
tgcctcggcg ggcgtcctgc gctggatgca gtgaaaaagg gattggggga tcctatcagc   2220
cgttcccagc tggtgaagtc cgagctggag gagaagaaat ccgagttgag gcacaagctg   2280
aagtacgtgc cccacgagta catcgagctg atcgagatcg cccggaacag cacccaggac   2340
cgtatcctgg agatgaaggt gatggagttc ttcatgaagg tgtacggcta caggggcaag   2400
cacctgggcg gctccaggaa gcccgacggc gccatctaca ccgtgggctc ccccatcgac   2460
tacggcgtga tcgtggacac caaggcctac tccggcggct acaacctgcc catcggccag   2520
gccgacgaaa tgcagaggta cgtggaggag aaccagacca ggaacaagca catcaacccc   2580
aacgagtggt ggaaggtgta cccctccagc gtgaccgagt tcaagttcct gttcgtgtcc   2640
ggccacttca agggcaacta caaggcccag ctgaccaggc tgaaccacat caccaactgc   2700
aacggcgccg tgctgtccgt ggaggagctc ctgatcggcg gcgagatgat caaggccggc   2760
accctgaccc tggaggaggt gaggaggaag ttcaacaacg gcgagatcaa cttcgcggcc   2820
gactgataa                                                           2829


<210>  28

<211>  49
<212>  DNA
<213>  artificial sequence

<220>
<223>  TALEN target TRAC

<400>  28
ttgtcccaca gatatccaga accctgaccc tgccgtgtac cagctgaga                 49


<210>  29

<211>  45
<212>  DNA
<213>  artificial sequence

<220>
<223>  TALEN target CD25

<400>  29
tacaggagga agagtagaag aacaatctag aaaaccaaaa gaaca                     45


<210>  30

<211>  49
<212>  DNA
<213>  artificial sequence

<220>
<223>  TALEN target PD1

<400>  30
tacctctgtg gggccatctc cctggccccc aaggcgcaga tcaaagaga                 49


<210>  31

<211>  2897
<212>  DNA
<213>  artificial sequence

<220>
<223>  Matrice TRAC locus_CubiCAR CD22 pCLS30056

<400>  31
ttgctgggcc tttttcccat gcctgccttt actctgccag agttatattg ctggggtttt     60
gaagaagatc ctattaaata aaagaataag cagtattatt aagtagccct gcatttcagg    120
tttccttgag tggcaggcca ggcctggccg tgaacgttca ctgaaatcat ggcctcttgg    180
ccaagattga tagcttgtgc ctgtccctga gtcccagtcc atcacgagca gctggtttct    240
aagatgctat ttcccgtata aagcatgaga ccgtgacttg ccagccccac agagccccgc    300
ccttgtccat cactggcatc tggactccag cctgggttgg ggcaaagagg gaaatgagat    360
catgtcctaa ccctgatcct cttgtcccac agatatccag tacccctacg acgtgcccga    420
ctacgcctcc ggtgagggca gaggaagtct tctaacatgc ggtgacgtgg aggagaatcc    480
gggccccgga tccgctctgc ccgtcaccgc tctgctgctg ccactggcac tgctgctgca    540
cgctgctagg cccggagggg gaggcagctg cccctacagc aaccccagcc tgtgcagcgg    600
aggcggcggc agcggcggag ggggtagcca ggtgcagctg cagcagagcg gccctggcct    660
ggtgaagcca agccagacac tgtccctgac ctgcgccatc agcggcgatt ccgtgagctc    720
caactccgcc gcctggaatt ggatcaggca gtccccttct cggggcctgg agtggctggg    780
aaggacatac tatcggtcta agtggtacaa cgattatgcc gtgtctgtga agagcagaat    840
cacaatcaac cctgacacct ccaagaatca gttctctctg cagctgaata gcgtgacacc    900
agaggacacc gccgtgtact attgcgccag ggaggtgacc ggcgacctgg aggatgcctt    960
tgacatctgg ggccagggca caatggtgac cgtgagctcc ggaggcggcg gatctggcgg   1020
aggaggaagt gggggcggcg ggagtgatat ccagatgaca cagtccccat cctctctgag   1080
cgcctccgtg ggcgacagag tgacaatcac ctgtagggcc tcccagacca tctggtctta   1140
cctgaactgg tatcagcaga ggcccggcaa ggcccctaat ctgctgatct acgcagcaag   1200
ctccctgcag agcggagtgc catccagatt ctctggcagg ggctccggca cagacttcac   1260
cctgaccatc tctagcctgc aggccgagga cttcgccacc tactattgcc agcagtctta   1320
tagcatcccc cagacatttg gccagggcac caagctggag atcaagtcgg atcccggaag   1380
cggaggggga ggcagctgcc cctacagcaa ccccagcctg tgcagcggag gcggcggcag   1440
cgagctgccc acccagggca ccttctccaa cgtgtccacc aacgtgagcc cagccaagcc   1500
caccaccacc gcctgtcctt attccaatcc ttccctgtgt gctcccacca caacccccgc   1560
tccaaggccc cctacccccg caccaactat tgcctcccag ccactctcac tgcggcctga   1620
ggcctgtcgg cccgctgctg gaggcgcagt gcatacaagg ggcctcgatt tcgcctgcga   1680
tatttacatc tgggcacccc tcgccggcac ctgcggggtg cttctcctct ccctggtgat   1740
taccctgtat tgcagacggg gccggaagaa gctcctctac atttttaagc agcctttcat   1800
gcggccagtg cagacaaccc aagaggagga tgggtgttcc tgcagattcc ctgaggaaga   1860
ggaaggcggg tgcgagctga gagtgaagtt ctccaggagc gcagatgccc ccgcctatca   1920
acagggccag aaccagctct acaacgagct taacctcggg aggcgcgaag aatacgacgt   1980
gttggataag agaagggggc gggaccccga gatgggagga aagccccgga ggaagaaccc   2040
tcaggagggc ctgtacaacg agctgcagaa ggataagatg gccgaggcct actcagagat   2100
cgggatgaag ggggagcggc gccgcgggaa ggggcacgat gggctctacc aggggctgag   2160
cacagccaca aaggacacat acgacgcctt gcacatgcag gcccttccac cccgggaata   2220
gtctagaggg cccgtttaaa cccgctgatc agcctcgact gtgccttcta gttgccagcc   2280
atctgttgtt tgcccctccc ccgtgccttc cttgaccctg gaaggtgcca ctcccactgt   2340
cctttcctaa taaaatgagg aaattgcatc gcattgtctg agtaggtgtc attctattct   2400
ggggggtggg gtggggcagg acagcaaggg ggaggattgg gaagacaata gcaggcatgc   2460
tggggatgcg gtgggctcta tgactagtgg cgaattcccg tgtaccagct gagagactct   2520
aaatccagtg acaagtctgt ctgcctattc accgattttg attctcaaac aaatgtgtca   2580
caaagtaagg attctgatgt gtatatcaca gacaaaactg tgctagacat gaggtctatg   2640
gacttcaaga gcaacagtgc tgtggcctgg agcaacaaat ctgactttgc atgtgcaaac   2700
gccttcaaca acagcattat tccagaagac accttcttcc ccagcccagg taagggcagc   2760
tttggtgcct tcgcaggctg tttccttgct tcaggaatgg ccaggttctg cccagagctc   2820
tggtcaatga tgtctaaaac tcctctgatt ggtggtctcg gccttatcca ttgccaccaa   2880
aaccctcttt ttactaa                                                  2897


<210>  32

<211>  2688
<212>  DNA
<213>  artificial sequence

<220>
<223>  Matrice CD25 locus_IL15_2A_sIL15Ra pCLS30519

<400>  32
gtttattatt cctgttccac agctattgtc tgccatataa aaacttaggc caggcacagt     60
ggctcacacc tgtaatccca gcactttgga aggccgaggc aggcagatca caaggtcagg    120
agttcgagac cagcctggcc aacatagcaa aaccccatct ctactaaaaa tacaaaaatt    180
agccaggcat ggtggcgtgt gcactggttt agagtgagga ccacattttt ttggtgccgt    240
gttacacata tgaccgtgac tttgttacac cactacagga ggaagagtag aagaacaatc    300
ggttctggcg tgaaacagac tttgaatttt gaccttctca agttggcggg agacgtggag    360
tccaacccag ggcccggtac cgggtccgcc accatggact ggacctggat tctgttcctc    420
gtggctgctg ctacaagagt gcacagcggc attcatgtct tcattttggg ctgtttcagt    480
gcagggcttc ctaaaacaga agccaactgg gtgaatgtaa taagtgattt gaaaaaaatt    540
gaagatctta ttcaatctat gcatattgat gctactttat atacggaaag tgatgttcac    600
cccagttgca aagtaacagc aatgaagtgc tttctcttgg agttacaagt tatttcactt    660
gagtccggag atgcaagtat tcatgataca gtagaaaatc tgatcatcct agcaaacaac    720
agtttgtctt ctaatgggaa tgtaacagaa tctggatgca aagaatgtga ggaactggag    780
gaaaaaaata ttaaagaatt tttgcagagt tttgtacata ttgtccaaat gttcatcaac    840
acttctggaa gcggagctac taacttcagc ctgctgaagc aggctggaga cgtggaggag    900
aaccctggac ctgggaccgg ctctgcaacc atggattgga cgtggatcct gtttctcgtg    960
gcagctgcca caagagttca cagtatcacg tgccctcccc ccatgtccgt ggaacacgca   1020
gacatctggg tcaagagcta cagcttgtac tccagggagc ggtacatttg taactctggt   1080
ttcaagcgta aagccggcac gtccagcctg acggagtgcg tgttgaacaa ggccacgaat   1140
gtcgcccact ggacaacccc cagtctcaaa tgcattagag accctgccct ggttcaccaa   1200
aggccagcgc caccctccac agtaacgacg gcaggggtga ccccacagcc agagagcctc   1260
tccccttctg gaaaagagcc cgcagcttca tctcccagct caaacaacac agcggccaca   1320
acagcagcta ttgtcccggg ctcccagctg atgccttcaa aatcaccttc cacaggaacc   1380
acagagataa gcagtcatga gtcctcccac ggcaccccct ctcagacaac agccaagaac   1440
tgggaactca cagcatccgc ctcccaccag ccgccaggtg tgtatccaca gggccacagc   1500
gacaccactg agggcagagg cagcctgctg acctgcggcg acgtcgagga gaaccccggg   1560
cccatggggg caggtgccac cggccgcgcc atggacgggc cgcgcctgct gctgttgctg   1620
cttctggggg tgtcccttgg aggtgccaag gaggcatgcc ccacaggcct gtacacacac   1680
agcggtgagt gctgcaaagc ctgcaacctg ggcgagggtg tggcccagcc ttgtggagcc   1740
aaccagaccg tgtgtgagcc ctgcctggac agcgtgacgt tctccgacgt ggtgagcgcg   1800
accgagccgt gcaagccgtg caccgagtgc gtggggctcc agagcatgtc ggcgccgtgc   1860
gtggaggccg atgacgccgt gtgccgctgc gcctacggct actaccagga tgagacgact   1920
gggcgctgcg aggcgtgccg cgtgtgcgag gcgggctcgg gcctcgtgtt ctcctgccag   1980
gacaagcaga acaccgtgtg cgaggagtgc cccgacggca cgtattccga cgaggccaac   2040
cacgtggacc cgtgcctgcc ctgcaccgtg tgcgaggaca ccgagcgcca gctccgcgag   2100
tgcacacgct gggccgacgc cgagtgcgag gagatccctg gccgttggat tacacggtcc   2160
acacccccag agggctcgga cagcacagcc cccagcaccc aggagcctga ggcacctcca   2220
gaacaagacc tcatagccag cacggtggca ggtgtggtga ccacagtgat gggcagctcc   2280
cagcccgtgg tgacccgagg caccaccgac aacctcatcc ctgtctattg ctccatcctg   2340
gctgctgtgg ttgtgggtct tgtggcctac atagccttca agaggtgaaa aaccaaaaga   2400
acaagaattt cttggtaaga agccgggaac agacaacaga agtcatgaag cccaagtgaa   2460
atcaaaggtg ctaaatggtc gcccaggaga catccgttgt gcttgcctgc gttttggaag   2520
ctctgaagtc acatcacagg acacggggca gtggcaacct tgtctctatg ccagctcagt   2580
cccatcagag agcgagcgct acccacttct aaatagcaat ttcgccgttg aagaggaagg   2640
gcaaaaccac tagaactctc catcttattt tcatgtatat gtgttcat                2688


<210>  33

<211>  2964
<212>  DNA
<213>  artificial sequence

<220>
<223>  Matrice PD1 locus_IL15_2A_sIL15Ra pCLS30513

<400>  33
gactccccag acaggccctg gaaccccccc accttctccc cagccctgct cgtggtgacc     60
gaaggggaca acgccacctt cacctgcagc ttctccaaca catcggagag cttcgtgcta    120
aactggtacc gcatgagccc cagcaaccag acggacaagc tggccgcctt ccccgaggac    180
cgcagccagc ccggccagga ctgccgcttc cgtgtcacac aactgcccaa cgggcgtgac    240
ttccacatga gcgtggtcag ggcccggcgc aatgacagcg gcacctacct ctgtggggcc    300
ggttctggcg tgaaacagac tttgaatttt gaccttctca agttggcggg agacgtggag    360
tccaacccag ggcccggtac cgggtccgcc accatggact ggacctggat tctgttcctc    420
gtggctgctg ctacaagagt gcacagcggc attcatgtct tcattttggg ctgtttcagt    480
gcagggcttc ctaaaacaga agccaactgg gtgaatgtaa taagtgattt gaaaaaaatt    540
gaagatctta ttcaatctat gcatattgat gctactttat atacggaaag tgatgttcac    600
cccagttgca aagtaacagc aatgaagtgc tttctcttgg agttacaagt tatttcactt    660
gagtccggag atgcaagtat tcatgataca gtagaaaatc tgatcatcct agcaaacaac    720
agtttgtctt ctaatgggaa tgtaacagaa tctggatgca aagaatgtga ggaactggag    780
gaaaaaaata ttaaagaatt tttgcagagt tttgtacata ttgtccaaat gttcatcaac    840
acttctggaa gcggagctac taacttcagc ctgctgaagc aggctggaga cgtggaggag    900
aaccctggac ctgggaccgg ctctgcaacc atggattgga cgtggatcct gtttctcgtg    960
gcagctgcca caagagttca cagtatcacg tgccctcccc ccatgtccgt ggaacacgca   1020
gacatctggg tcaagagcta cagcttgtac tccagggagc ggtacatttg taactctggt   1080
ttcaagcgta aagccggcac gtccagcctg acggagtgcg tgttgaacaa ggccacgaat   1140
gtcgcccact ggacaacccc cagtctcaaa tgcattagag accctgccct ggttcaccaa   1200
aggccagcgc caccctccac agtaacgacg gcaggggtga ccccacagcc agagagcctc   1260
tccccttctg gaaaagagcc cgcagcttca tctcccagct caaacaacac agcggccaca   1320
acagcagcta ttgtcccggg ctcccagctg atgccttcaa aatcaccttc cacaggaacc   1380
acagagataa gcagtcatga gtcctcccac ggcaccccct ctcagacaac agccaagaac   1440
tgggaactca cagcatccgc ctcccaccag ccgccaggtg tgtatccaca gggccacagc   1500
gacaccactg agggcagagg cagcctgctg acctgcggcg acgtcgagga gaaccccggg   1560
cccatggggg caggtgccac cggccgcgcc atggacgggc cgcgcctgct gctgttgctg   1620
cttctggggg tgtcccttgg aggtgccaag gaggcatgcc ccacaggcct gtacacacac   1680
agcggtgagt gctgcaaagc ctgcaacctg ggcgagggtg tggcccagcc ttgtggagcc   1740
aaccagaccg tgtgtgagcc ctgcctggac agcgtgacgt tctccgacgt ggtgagcgcg   1800
accgagccgt gcaagccgtg caccgagtgc gtggggctcc agagcatgtc ggcgccgtgc   1860
gtggaggccg atgacgccgt gtgccgctgc gcctacggct actaccagga tgagacgact   1920
gggcgctgcg aggcgtgccg cgtgtgcgag gcgggctcgg gcctcgtgtt ctcctgccag   1980
gacaagcaga acaccgtgtg cgaggagtgc cccgacggca cgtattccga cgaggccaac   2040
cacgtggacc cgtgcctgcc ctgcaccgtg tgcgaggaca ccgagcgcca gctccgcgag   2100
tgcacacgct gggccgacgc cgagtgcgag gagatccctg gccgttggat tacacggtcc   2160
acacccccag agggctcgga cagcacagcc cccagcaccc aggagcctga ggcacctcca   2220
gaacaagacc tcatagccag cacggtggca ggtgtggtga ccacagtgat gggcagctcc   2280
cagcccgtgg tgacccgagg caccaccgac aacctcatcc ctgtctattg ctccatcctg   2340
gctgctgtgg ttgtgggtct tgtggcctac atagccttca agaggtgatc tagagggccc   2400
gtttaaaccc gctgatcagc ctcgactgtg ccttctagtt gccagccatc tgttgtttgc   2460
ccctcccccg tgccttcctt gaccctggaa ggtgccactc ccactgtcct ttcctaataa   2520
aatgaggaaa ttgcatcgca ttgtctgagt aggtgtcatt ctattctggg gggtggggtg   2580
gggcaggaca gcaaggggga ggattgggaa gacaatagca ggcatgctgg ggatgcggtg   2640
ggctctatga ctagtggcga attcggcgca gatcaaagag agcctgcggg cagagctcag   2700
ggtgacaggt gcggcctcgg aggccccggg gcaggggtga gctgagccgg tcctggggtg   2760
ggtgtcccct cctgcacagg atcaggagct ccagggtcgt agggcaggga ccccccagct   2820
ccagtccagg gctctgtcct gcacctgggg aatggtgacc ggcatctctg tcctctagct   2880
ctggaagcac cccagcccct ctagtctgcc ctcacccctg accctgaccc tccaccctga   2940
ccccgtccta acccctgacc tttg                                          2964


<210>  34

<211>  3363
<212>  DNA
<213>  artificial sequence

<220>
<223>  Matrice CD25 locus_IL12a_2A_IL12b pCLS30520

<400>  34
gtttattatt cctgttccac agctattgtc tgccatataa aaacttaggc caggcacagt     60
ggctcacacc tgtaatccca gcactttgga aggccgaggc aggcagatca caaggtcagg    120
agttcgagac cagcctggcc aacatagcaa aaccccatct ctactaaaaa tacaaaaatt    180
agccaggcat ggtggcgtgt gcactggttt agagtgagga ccacattttt ttggtgccgt    240
gttacacata tgaccgtgac tttgttacac cactacagga ggaagagtag aagaacaatc    300
ggttctggcg tgaaacagac tttgaatttt gaccttctca agttggcggg agacgtggag    360
tccaacccag ggcccatgtg gccccctggg tcagcctccc agccaccgcc ctcacctgcc    420
gcggccacag gtctgcatcc agcggctcgc cctgtgtccc tgcagtgccg gctcagcatg    480
tgtccagcgc gcagcctcct ccttgtggct accctggtcc tcctggacca cctcagtttg    540
gccagaaacc tccccgtggc cactccagac ccaggaatgt tcccatgcct tcaccactcc    600
caaaacctgc tgagggccgt cagcaacatg ctccagaagg ccagacaaac tctagaattt    660
tacccttgca cttctgaaga gattgatcat gaagatatca caaaagataa aaccagcaca    720
gtggaggcct gtttaccatt ggaattaacc aagaatgaga gttgcctaaa ttccagagag    780
acctctttca taactaatgg gagttgcctg gcctccagaa agacctcttt tatgatggcc    840
ctgtgcctta gtagtattta tgaagacttg aagatgtacc aggtggagtt caagaccatg    900
aatgcaaagc ttctgatgga tcctaagagg cagatctttc tagatcaaaa catgctggca    960
gttattgatg agctgatgca ggccctgaat ttcaacagtg agactgtgcc acaaaaatcc   1020
tcccttgaag aaccggattt ttataaaact aaaatcaagc tctgcatact tcttcatgct   1080
ttcagaattc gggcagtgac tattgataga gtgatgagct atctgaatgc ttccggaagc   1140
ggagctacta acttcagcct gctgaagcag gctggagacg tggaggagaa ccctggacct   1200
atgtgtcacc agcagttggt catctcttgg ttttccctgg tttttctggc atctcccctc   1260
gtggccatat gggaactgaa gaaagatgtt tatgtcgtag aattggattg gtatccggat   1320
gcccctggag aaatggtggt cctcacctgt gacacccctg aagaagatgg tatcacctgg   1380
accttggacc agagcagtga ggtcttaggc tctggcaaaa ccctgaccat ccaagtcaaa   1440
gagtttggag atgctggcca gtacacctgt cacaaaggag gcgaggttct aagccattcg   1500
ctcctgctgc ttcacaaaaa ggaagatgga atttggtcca ctgatatttt aaaggaccag   1560
aaagaaccca aaaataagac ctttctaaga tgcgaggcca agaattattc tggacgtttc   1620
acctgctggt ggctgacgac aatcagtact gatttgacat tcagtgtcaa aagcagcaga   1680
ggctcttctg acccccaagg ggtgacgtgc ggagctgcta cactctctgc agagagagtc   1740
agaggggaca acaaggagta tgagtactca gtggagtgcc aggaggacag tgcctgccca   1800
gctgctgagg agagtctgcc cattgaggtc atggtggatg ccgttcacaa gctcaagtat   1860
gaaaactaca ccagcagctt cttcatcagg gacatcatca aacctgaccc acccaagaac   1920
ttgcagctga agccattaaa gaattctcgg caggtggagg tcagctggga gtaccctgac   1980
acctggagta ctccacattc ctacttctcc ctgacattct gcgttcaggt ccagggcaag   2040
agcaagagag aaaagaaaga tagagtcttc acggacaaga cctcagccac ggtcatctgc   2100
cgcaaaaatg ccagcattag cgtgcgggcc caggaccgct actatagctc atcttggagc   2160
gaatgggcat ctgtgccctg cagtgagggc agaggcagcc tgctgacctg cggcgacgtc   2220
gaggagaacc ccgggcccat gggggcaggt gccaccggcc gcgccatgga cgggccgcgc   2280
ctgctgctgt tgctgcttct gggggtgtcc cttggaggtg ccaaggaggc atgccccaca   2340
ggcctgtaca cacacagcgg tgagtgctgc aaagcctgca acctgggcga gggtgtggcc   2400
cagccttgtg gagccaacca gaccgtgtgt gagccctgcc tggacagcgt gacgttctcc   2460
gacgtggtga gcgcgaccga gccgtgcaag ccgtgcaccg agtgcgtggg gctccagagc   2520
atgtcggcgc cgtgcgtgga ggccgatgac gccgtgtgcc gctgcgccta cggctactac   2580
caggatgaga cgactgggcg ctgcgaggcg tgccgcgtgt gcgaggcggg ctcgggcctc   2640
gtgttctcct gccaggacaa gcagaacacc gtgtgcgagg agtgccccga cggcacgtat   2700
tccgacgagg ccaaccacgt ggacccgtgc ctgccctgca ccgtgtgcga ggacaccgag   2760
cgccagctcc gcgagtgcac acgctgggcc gacgccgagt gcgaggagat ccctggccgt   2820
tggattacac ggtccacacc cccagagggc tcggacagca cagcccccag cacccaggag   2880
cctgaggcac ctccagaaca agacctcata gccagcacgg tggcaggtgt ggtgaccaca   2940
gtgatgggca gctcccagcc cgtggtgacc cgaggcacca ccgacaacct catccctgtc   3000
tattgctcca tcctggctgc tgtggttgtg ggtcttgtgg cctacatagc cttcaagagg   3060
tgaaaaacca aaagaacaag aatttcttgg taagaagccg ggaacagaca acagaagtca   3120
tgaagcccaa gtgaaatcaa aggtgctaaa tggtcgccca ggagacatcc gttgtgcttg   3180
cctgcgtttt ggaagctctg aagtcacatc acaggacacg gggcagtggc aaccttgtct   3240
ctatgccagc tcagtcccat cagagagcga gcgctaccca cttctaaata gcaatttcgc   3300
cgttgaagag gaagggcaaa accactagaa ctctccatct tattttcatg tatatgtgtt   3360
cat                                                                 3363


<210>  35

<211>  3639
<212>  DNA
<213>  artificial sequence

<220>
<223>  Matrice PD1 locus_IL12a_2A_IL12b pCLS30511

<400>  35
gactccccag acaggccctg gaaccccccc accttctccc cagccctgct cgtggtgacc     60
gaaggggaca acgccacctt cacctgcagc ttctccaaca catcggagag cttcgtgcta    120
aactggtacc gcatgagccc cagcaaccag acggacaagc tggccgcctt ccccgaggac    180
cgcagccagc ccggccagga ctgccgcttc cgtgtcacac aactgcccaa cgggcgtgac    240
ttccacatga gcgtggtcag ggcccggcgc aatgacagcg gcacctacct ctgtggggcc    300
ggttctggcg tgaaacagac tttgaatttt gaccttctca agttggcggg agacgtggag    360
tccaacccag ggcccatgtg gccccctggg tcagcctccc agccaccgcc ctcacctgcc    420
gcggccacag gtctgcatcc agcggctcgc cctgtgtccc tgcagtgccg gctcagcatg    480
tgtccagcgc gcagcctcct ccttgtggct accctggtcc tcctggacca cctcagtttg    540
gccagaaacc tccccgtggc cactccagac ccaggaatgt tcccatgcct tcaccactcc    600
caaaacctgc tgagggccgt cagcaacatg ctccagaagg ccagacaaac tctagaattt    660
tacccttgca cttctgaaga gattgatcat gaagatatca caaaagataa aaccagcaca    720
gtggaggcct gtttaccatt ggaattaacc aagaatgaga gttgcctaaa ttccagagag    780
acctctttca taactaatgg gagttgcctg gcctccagaa agacctcttt tatgatggcc    840
ctgtgcctta gtagtattta tgaagacttg aagatgtacc aggtggagtt caagaccatg    900
aatgcaaagc ttctgatgga tcctaagagg cagatctttc tagatcaaaa catgctggca    960
gttattgatg agctgatgca ggccctgaat ttcaacagtg agactgtgcc acaaaaatcc   1020
tcccttgaag aaccggattt ttataaaact aaaatcaagc tctgcatact tcttcatgct   1080
ttcagaattc gggcagtgac tattgataga gtgatgagct atctgaatgc ttccggaagc   1140
ggagctacta acttcagcct gctgaagcag gctggagacg tggaggagaa ccctggacct   1200
atgtgtcacc agcagttggt catctcttgg ttttccctgg tttttctggc atctcccctc   1260
gtggccatat gggaactgaa gaaagatgtt tatgtcgtag aattggattg gtatccggat   1320
gcccctggag aaatggtggt cctcacctgt gacacccctg aagaagatgg tatcacctgg   1380
accttggacc agagcagtga ggtcttaggc tctggcaaaa ccctgaccat ccaagtcaaa   1440
gagtttggag atgctggcca gtacacctgt cacaaaggag gcgaggttct aagccattcg   1500
ctcctgctgc ttcacaaaaa ggaagatgga atttggtcca ctgatatttt aaaggaccag   1560
aaagaaccca aaaataagac ctttctaaga tgcgaggcca agaattattc tggacgtttc   1620
acctgctggt ggctgacgac aatcagtact gatttgacat tcagtgtcaa aagcagcaga   1680
ggctcttctg acccccaagg ggtgacgtgc ggagctgcta cactctctgc agagagagtc   1740
agaggggaca acaaggagta tgagtactca gtggagtgcc aggaggacag tgcctgccca   1800
gctgctgagg agagtctgcc cattgaggtc atggtggatg ccgttcacaa gctcaagtat   1860
gaaaactaca ccagcagctt cttcatcagg gacatcatca aacctgaccc acccaagaac   1920
ttgcagctga agccattaaa gaattctcgg caggtggagg tcagctggga gtaccctgac   1980
acctggagta ctccacattc ctacttctcc ctgacattct gcgttcaggt ccagggcaag   2040
agcaagagag aaaagaaaga tagagtcttc acggacaaga cctcagccac ggtcatctgc   2100
cgcaaaaatg ccagcattag cgtgcgggcc caggaccgct actatagctc atcttggagc   2160
gaatgggcat ctgtgccctg cagtgagggc agaggcagcc tgctgacctg cggcgacgtc   2220
gaggagaacc ccgggcccat gggggcaggt gccaccggcc gcgccatgga cgggccgcgc   2280
ctgctgctgt tgctgcttct gggggtgtcc cttggaggtg ccaaggaggc atgccccaca   2340
ggcctgtaca cacacagcgg tgagtgctgc aaagcctgca acctgggcga gggtgtggcc   2400
cagccttgtg gagccaacca gaccgtgtgt gagccctgcc tggacagcgt gacgttctcc   2460
gacgtggtga gcgcgaccga gccgtgcaag ccgtgcaccg agtgcgtggg gctccagagc   2520
atgtcggcgc cgtgcgtgga ggccgatgac gccgtgtgcc gctgcgccta cggctactac   2580
caggatgaga cgactgggcg ctgcgaggcg tgccgcgtgt gcgaggcggg ctcgggcctc   2640
gtgttctcct gccaggacaa gcagaacacc gtgtgcgagg agtgccccga cggcacgtat   2700
tccgacgagg ccaaccacgt ggacccgtgc ctgccctgca ccgtgtgcga ggacaccgag   2760
cgccagctcc gcgagtgcac acgctgggcc gacgccgagt gcgaggagat ccctggccgt   2820
tggattacac ggtccacacc cccagagggc tcggacagca cagcccccag cacccaggag   2880
cctgaggcac ctccagaaca agacctcata gccagcacgg tggcaggtgt ggtgaccaca   2940
gtgatgggca gctcccagcc cgtggtgacc cgaggcacca ccgacaacct catccctgtc   3000
tattgctcca tcctggctgc tgtggttgtg ggtcttgtgg cctacatagc cttcaagagg   3060
tgatctagag ggcccgttta aacccgctga tcagcctcga ctgtgccttc tagttgccag   3120
ccatctgttg tttgcccctc ccccgtgcct tccttgaccc tggaaggtgc cactcccact   3180
gtcctttcct aataaaatga ggaaattgca tcgcattgtc tgagtaggtg tcattctatt   3240
ctggggggtg gggtggggca ggacagcaag ggggaggatt gggaagacaa tagcaggcat   3300
gctggggatg cggtgggctc tatgactagt ggcgaattcg gcgcagatca aagagagcct   3360
gcgggcagag ctcagggtga caggtgcggc ctcggaggcc ccggggcagg ggtgagctga   3420
gccggtcctg gggtgggtgt cccctcctgc acaggatcag gagctccagg gtcgtagggc   3480
agggaccccc cagctccagt ccagggctct gtcctgcacc tggggaatgg tgaccggcat   3540
ctctgtcctc tagctctgga agcaccccag cccctctagt ctgccctcac ccctgaccct   3600
gaccctccac cctgaccccg tcctaacccc tgacctttg                          3639


<210>  36

<211>  3017
<212>  DNA
<213>  artificial sequence

<220>
<223>  Inserted matrice TRAC locus_CubiCAR CD22 (60 nucleotides upstream and downstream)

<400>  36
atgagatcat gtcctaaccc tgatcctctt gtcccacaga tatccagaac cctgaccctg     60
ttgctgggcc tttttcccat gcctgccttt actctgccag agttatattg ctggggtttt    120
gaagaagatc ctattaaata aaagaataag cagtattatt aagtagccct gcatttcagg    180
tttccttgag tggcaggcca ggcctggccg tgaacgttca ctgaaatcat ggcctcttgg    240
ccaagattga tagcttgtgc ctgtccctga gtcccagtcc atcacgagca gctggtttct    300
aagatgctat ttcccgtata aagcatgaga ccgtgacttg ccagccccac agagccccgc    360
ccttgtccat cactggcatc tggactccag cctgggttgg ggcaaagagg gaaatgagat    420
catgtcctaa ccctgatcct cttgtcccac agatatccag tacccctacg acgtgcccga    480
ctacgcctcc ggtgagggca gaggaagtct tctaacatgc ggtgacgtgg aggagaatcc    540
gggccccgga tccgctctgc ccgtcaccgc tctgctgctg ccactggcac tgctgctgca    600
cgctgctagg cccggagggg gaggcagctg cccctacagc aaccccagcc tgtgcagcgg    660
aggcggcggc agcggcggag ggggtagcca ggtgcagctg cagcagagcg gccctggcct    720
ggtgaagcca agccagacac tgtccctgac ctgcgccatc agcggcgatt ccgtgagctc    780
caactccgcc gcctggaatt ggatcaggca gtccccttct cggggcctgg agtggctggg    840
aaggacatac tatcggtcta agtggtacaa cgattatgcc gtgtctgtga agagcagaat    900
cacaatcaac cctgacacct ccaagaatca gttctctctg cagctgaata gcgtgacacc    960
agaggacacc gccgtgtact attgcgccag ggaggtgacc ggcgacctgg aggatgcctt   1020
tgacatctgg ggccagggca caatggtgac cgtgagctcc ggaggcggcg gatctggcgg   1080
aggaggaagt gggggcggcg ggagtgatat ccagatgaca cagtccccat cctctctgag   1140
cgcctccgtg ggcgacagag tgacaatcac ctgtagggcc tcccagacca tctggtctta   1200
cctgaactgg tatcagcaga ggcccggcaa ggcccctaat ctgctgatct acgcagcaag   1260
ctccctgcag agcggagtgc catccagatt ctctggcagg ggctccggca cagacttcac   1320
cctgaccatc tctagcctgc aggccgagga cttcgccacc tactattgcc agcagtctta   1380
tagcatcccc cagacatttg gccagggcac caagctggag atcaagtcgg atcccggaag   1440
cggaggggga ggcagctgcc cctacagcaa ccccagcctg tgcagcggag gcggcggcag   1500
cgagctgccc acccagggca ccttctccaa cgtgtccacc aacgtgagcc cagccaagcc   1560
caccaccacc gcctgtcctt attccaatcc ttccctgtgt gctcccacca caacccccgc   1620
tccaaggccc cctacccccg caccaactat tgcctcccag ccactctcac tgcggcctga   1680
ggcctgtcgg cccgctgctg gaggcgcagt gcatacaagg ggcctcgatt tcgcctgcga   1740
tatttacatc tgggcacccc tcgccggcac ctgcggggtg cttctcctct ccctggtgat   1800
taccctgtat tgcagacggg gccggaagaa gctcctctac atttttaagc agcctttcat   1860
gcggccagtg cagacaaccc aagaggagga tgggtgttcc tgcagattcc ctgaggaaga   1920
ggaaggcggg tgcgagctga gagtgaagtt ctccaggagc gcagatgccc ccgcctatca   1980
acagggccag aaccagctct acaacgagct taacctcggg aggcgcgaag aatacgacgt   2040
gttggataag agaagggggc gggaccccga gatgggagga aagccccgga ggaagaaccc   2100
tcaggagggc ctgtacaacg agctgcagaa ggataagatg gccgaggcct actcagagat   2160
cgggatgaag ggggagcggc gccgcgggaa ggggcacgat gggctctacc aggggctgag   2220
cacagccaca aaggacacat acgacgcctt gcacatgcag gcccttccac cccgggaata   2280
gtctagaggg cccgtttaaa cccgctgatc agcctcgact gtgccttcta gttgccagcc   2340
atctgttgtt tgcccctccc ccgtgccttc cttgaccctg gaaggtgcca ctcccactgt   2400
cctttcctaa taaaatgagg aaattgcatc gcattgtctg agtaggtgtc attctattct   2460
ggggggtggg gtggggcagg acagcaaggg ggaggattgg gaagacaata gcaggcatgc   2520
tggggatgcg gtgggctcta tgactagtgg cgaattcccg tgtaccagct gagagactct   2580
aaatccagtg acaagtctgt ctgcctattc accgattttg attctcaaac aaatgtgtca   2640
caaagtaagg attctgatgt gtatatcaca gacaaaactg tgctagacat gaggtctatg   2700
gacttcaaga gcaacagtgc tgtggcctgg agcaacaaat ctgactttgc atgtgcaaac   2760
gccttcaaca acagcattat tccagaagac accttcttcc ccagcccagg taagggcagc   2820
tttggtgcct tcgcaggctg tttccttgct tcaggaatgg ccaggttctg cccagagctc   2880
tggtcaatga tgtctaaaac tcctctgatt ggtggtctcg gccttatcca ttgccaccaa   2940
aaccctcttt ttactaagaa acagtgagcc ttgttctggc agtccagaga atgacacggg   3000
aaaaaagcag atgaaga                                                  3017


<210>  37

<211>  2808
<212>  DNA
<213>  artificial sequence

<220>
<223>  Inserted matrice CD25 locus_IL15_2A_sIL15Ra (60 nucleotides upstream and downstream)

<400>  37
agtgctggct agaaaccaag tgctttactg catgcacatc atttagcaca gttagttgct     60
gtttattatt cctgttccac agctattgtc tgccatataa aaacttaggc caggcacagt    120
ggctcacacc tgtaatccca gcactttgga aggccgaggc aggcagatca caaggtcagg    180
agttcgagac cagcctggcc aacatagcaa aaccccatct ctactaaaaa tacaaaaatt    240
agccaggcat ggtggcgtgt gcactggttt agagtgagga ccacattttt ttggtgccgt    300
gttacacata tgaccgtgac tttgttacac cactacagga ggaagagtag aagaacaatc    360
ggttctggcg tgaaacagac tttgaatttt gaccttctca agttggcggg agacgtggag    420
tccaacccag ggcccggtac cgggtccgcc accatggact ggacctggat tctgttcctc    480
gtggctgctg ctacaagagt gcacagcggc attcatgtct tcattttggg ctgtttcagt    540
gcagggcttc ctaaaacaga agccaactgg gtgaatgtaa taagtgattt gaaaaaaatt    600
gaagatctta ttcaatctat gcatattgat gctactttat atacggaaag tgatgttcac    660
cccagttgca aagtaacagc aatgaagtgc tttctcttgg agttacaagt tatttcactt    720
gagtccggag atgcaagtat tcatgataca gtagaaaatc tgatcatcct agcaaacaac    780
agtttgtctt ctaatgggaa tgtaacagaa tctggatgca aagaatgtga ggaactggag    840
gaaaaaaata ttaaagaatt tttgcagagt tttgtacata ttgtccaaat gttcatcaac    900
acttctggaa gcggagctac taacttcagc ctgctgaagc aggctggaga cgtggaggag    960
aaccctggac ctgggaccgg ctctgcaacc atggattgga cgtggatcct gtttctcgtg   1020
gcagctgcca caagagttca cagtatcacg tgccctcccc ccatgtccgt ggaacacgca   1080
gacatctggg tcaagagcta cagcttgtac tccagggagc ggtacatttg taactctggt   1140
ttcaagcgta aagccggcac gtccagcctg acggagtgcg tgttgaacaa ggccacgaat   1200
gtcgcccact ggacaacccc cagtctcaaa tgcattagag accctgccct ggttcaccaa   1260
aggccagcgc caccctccac agtaacgacg gcaggggtga ccccacagcc agagagcctc   1320
tccccttctg gaaaagagcc cgcagcttca tctcccagct caaacaacac agcggccaca   1380
acagcagcta ttgtcccggg ctcccagctg atgccttcaa aatcaccttc cacaggaacc   1440
acagagataa gcagtcatga gtcctcccac ggcaccccct ctcagacaac agccaagaac   1500
tgggaactca cagcatccgc ctcccaccag ccgccaggtg tgtatccaca gggccacagc   1560
gacaccactg agggcagagg cagcctgctg acctgcggcg acgtcgagga gaaccccggg   1620
cccatggggg caggtgccac cggccgcgcc atggacgggc cgcgcctgct gctgttgctg   1680
cttctggggg tgtcccttgg aggtgccaag gaggcatgcc ccacaggcct gtacacacac   1740
agcggtgagt gctgcaaagc ctgcaacctg ggcgagggtg tggcccagcc ttgtggagcc   1800
aaccagaccg tgtgtgagcc ctgcctggac agcgtgacgt tctccgacgt ggtgagcgcg   1860
accgagccgt gcaagccgtg caccgagtgc gtggggctcc agagcatgtc ggcgccgtgc   1920
gtggaggccg atgacgccgt gtgccgctgc gcctacggct actaccagga tgagacgact   1980
gggcgctgcg aggcgtgccg cgtgtgcgag gcgggctcgg gcctcgtgtt ctcctgccag   2040
gacaagcaga acaccgtgtg cgaggagtgc cccgacggca cgtattccga cgaggccaac   2100
cacgtggacc cgtgcctgcc ctgcaccgtg tgcgaggaca ccgagcgcca gctccgcgag   2160
tgcacacgct gggccgacgc cgagtgcgag gagatccctg gccgttggat tacacggtcc   2220
acacccccag agggctcgga cagcacagcc cccagcaccc aggagcctga ggcacctcca   2280
gaacaagacc tcatagccag cacggtggca ggtgtggtga ccacagtgat gggcagctcc   2340
cagcccgtgg tgacccgagg caccaccgac aacctcatcc ctgtctattg ctccatcctg   2400
gctgctgtgg ttgtgggtct tgtggcctac atagccttca agaggtgaaa aaccaaaaga   2460
acaagaattt cttggtaaga agccgggaac agacaacaga agtcatgaag cccaagtgaa   2520
atcaaaggtg ctaaatggtc gcccaggaga catccgttgt gcttgcctgc gttttggaag   2580
ctctgaagtc acatcacagg acacggggca gtggcaacct tgtctctatg ccagctcagt   2640
cccatcagag agcgagcgct acccacttct aaatagcaat ttcgccgttg aagaggaagg   2700
gcaaaaccac tagaactctc catcttattt tcatgtatat gtgttcatta aagcatgaat   2760
ggtatggaac tctctccacc ctatatgtag tataaagaaa agtaggtt                2808


<210>  38

<211>  3084
<212>  DNA
<213>  artificial sequence

<220>
<223>  Inserted matrice PD1 locus_IL15_2A_sIL15Ra (60 nucleotides upstream and downstream)

<400>  38
ggtggccggg gaggctttgt ggggccaccc agccccttcc tcacctctct ccatctctca     60
gactccccag acaggccctg gaaccccccc accttctccc cagccctgct cgtggtgacc    120
gaaggggaca acgccacctt cacctgcagc ttctccaaca catcggagag cttcgtgcta    180
aactggtacc gcatgagccc cagcaaccag acggacaagc tggccgcctt ccccgaggac    240
cgcagccagc ccggccagga ctgccgcttc cgtgtcacac aactgcccaa cgggcgtgac    300
ttccacatga gcgtggtcag ggcccggcgc aatgacagcg gcacctacct ctgtggggcc    360
ggttctggcg tgaaacagac tttgaatttt gaccttctca agttggcggg agacgtggag    420
tccaacccag ggcccggtac cgggtccgcc accatggact ggacctggat tctgttcctc    480
gtggctgctg ctacaagagt gcacagcggc attcatgtct tcattttggg ctgtttcagt    540
gcagggcttc ctaaaacaga agccaactgg gtgaatgtaa taagtgattt gaaaaaaatt    600
gaagatctta ttcaatctat gcatattgat gctactttat atacggaaag tgatgttcac    660
cccagttgca aagtaacagc aatgaagtgc tttctcttgg agttacaagt tatttcactt    720
gagtccggag atgcaagtat tcatgataca gtagaaaatc tgatcatcct agcaaacaac    780
agtttgtctt ctaatgggaa tgtaacagaa tctggatgca aagaatgtga ggaactggag    840
gaaaaaaata ttaaagaatt tttgcagagt tttgtacata ttgtccaaat gttcatcaac    900
acttctggaa gcggagctac taacttcagc ctgctgaagc aggctggaga cgtggaggag    960
aaccctggac ctgggaccgg ctctgcaacc atggattgga cgtggatcct gtttctcgtg   1020
gcagctgcca caagagttca cagtatcacg tgccctcccc ccatgtccgt ggaacacgca   1080
gacatctggg tcaagagcta cagcttgtac tccagggagc ggtacatttg taactctggt   1140
ttcaagcgta aagccggcac gtccagcctg acggagtgcg tgttgaacaa ggccacgaat   1200
gtcgcccact ggacaacccc cagtctcaaa tgcattagag accctgccct ggttcaccaa   1260
aggccagcgc caccctccac agtaacgacg gcaggggtga ccccacagcc agagagcctc   1320
tccccttctg gaaaagagcc cgcagcttca tctcccagct caaacaacac agcggccaca   1380
acagcagcta ttgtcccggg ctcccagctg atgccttcaa aatcaccttc cacaggaacc   1440
acagagataa gcagtcatga gtcctcccac ggcaccccct ctcagacaac agccaagaac   1500
tgggaactca cagcatccgc ctcccaccag ccgccaggtg tgtatccaca gggccacagc   1560
gacaccactg agggcagagg cagcctgctg acctgcggcg acgtcgagga gaaccccggg   1620
cccatggggg caggtgccac cggccgcgcc atggacgggc cgcgcctgct gctgttgctg   1680
cttctggggg tgtcccttgg aggtgccaag gaggcatgcc ccacaggcct gtacacacac   1740
agcggtgagt gctgcaaagc ctgcaacctg ggcgagggtg tggcccagcc ttgtggagcc   1800
aaccagaccg tgtgtgagcc ctgcctggac agcgtgacgt tctccgacgt ggtgagcgcg   1860
accgagccgt gcaagccgtg caccgagtgc gtggggctcc agagcatgtc ggcgccgtgc   1920
gtggaggccg atgacgccgt gtgccgctgc gcctacggct actaccagga tgagacgact   1980
gggcgctgcg aggcgtgccg cgtgtgcgag gcgggctcgg gcctcgtgtt ctcctgccag   2040
gacaagcaga acaccgtgtg cgaggagtgc cccgacggca cgtattccga cgaggccaac   2100
cacgtggacc cgtgcctgcc ctgcaccgtg tgcgaggaca ccgagcgcca gctccgcgag   2160
tgcacacgct gggccgacgc cgagtgcgag gagatccctg gccgttggat tacacggtcc   2220
acacccccag agggctcgga cagcacagcc cccagcaccc aggagcctga ggcacctcca   2280
gaacaagacc tcatagccag cacggtggca ggtgtggtga ccacagtgat gggcagctcc   2340
cagcccgtgg tgacccgagg caccaccgac aacctcatcc ctgtctattg ctccatcctg   2400
gctgctgtgg ttgtgggtct tgtggcctac atagccttca agaggtgatc tagagggccc   2460
gtttaaaccc gctgatcagc ctcgactgtg ccttctagtt gccagccatc tgttgtttgc   2520
ccctcccccg tgccttcctt gaccctggaa ggtgccactc ccactgtcct ttcctaataa   2580
aatgaggaaa ttgcatcgca ttgtctgagt aggtgtcatt ctattctggg gggtggggtg   2640
gggcaggaca gcaaggggga ggattgggaa gacaatagca ggcatgctgg ggatgcggtg   2700
ggctctatga ctagtggcga attcggcgca gatcaaagag agcctgcggg cagagctcag   2760
ggtgacaggt gcggcctcgg aggccccggg gcaggggtga gctgagccgg tcctggggtg   2820
ggtgtcccct cctgcacagg atcaggagct ccagggtcgt agggcaggga ccccccagct   2880
ccagtccagg gctctgtcct gcacctgggg aatggtgacc ggcatctctg tcctctagct   2940
ctggaagcac cccagcccct ctagtctgcc ctcacccctg accctgaccc tccaccctga   3000
ccccgtccta acccctgacc tttgtgccct tccagagaga agggcagaag tgcccacagc   3060
ccaccccagc ccctcaccca ggcc                                          3084


<210>  39

<211>  3475
<212>  DNA
<213>  artificial sequence

<220>
<223>  Inserted matrice  CD25 locus_IL12a_2A_IL12b (60 nucleotides upstream and downstream)

<400>  39
agtgctggct agaaaccaag tgctttactg catgcacatc atttagcaca gttagttgct     60
gtttattatt cctgttccac agctattgtc tgccatataa aaacttaggc caggcacagt    120
ggctcacacc tgtaatccca gcactttgga aggccgaggc aggcagatca caaggtcagg    180
agttcgagac cagcctggcc aacatagcaa aaccccatct ctactaaaaa tacaaaaatt    240
agccaggcat ggtggcgtgt gcactggttt agagtgagga ccacattttt ttggtgccgt    300
gttacacata tgaccgtgac tttgttacac cactacagga ggaagagtag aagaacaatc    360
ggttctggcg tgaaacagac tttgaatttt gaccttctca agttggcggg agacgtggag    420
tccaacccag ggcccatgtg gccccctggg tcagcctccc agccaccgcc ctcacctgcc    480
gcggccacag gtctgcatcc agcggctcgc cctgtgtccc tgcagtgccg gctcagcatg    540
tgtccagcgc gcagcctcct ccttgtggct accctggtcc tcctggacca cctcagtttg    600
gccagaaacc tccccgtggc cactccagac ccaggaatgt tcccatgcct tcaccactcc    660
caaaacctgc tgagggccgt cagcaacatg ctccagaagg ccagacaaac tctagaattt    720
tacccttgca cttctgaaga gattgatcat gaagatatca caaaagataa aaccagcaca    780
gtggaggcct gtttaccatt ggaattaacc aagaatgaga gttgcctaaa ttccagagag    840
acctctttca taactaatgg gagttgcctg gcctccagaa agacctcttt tatgatggcc    900
ctgtgcctta gtagtattta tgaagacttg aagatgtacc aggtggagtt caagaccatg    960
aatgcaaagc ttctgatgga tcctaagagg cagatctttc tagatcaaaa catgctggca   1020
gttattgatg agctgatgca ggccctgaat ttcaacagtg agactgtgcc acaaaaatcc   1080
tcccttgaag aaccggattt ttataaaact aaaatcaagc tctgcatact tcttcatgct   1140
ttcagaattc gggcagtgac tattgataga gtgatgagct atctgaatgc ttccggaagc   1200
ggagctacta acttcagcct gctgaagcag gctggagacg tggaggagaa ccctggacct   1260
atgtgtcacc agcagttggt catctcttgg ttttccctgg tttttctggc atctcccctc   1320
gtggccatat gggaactgaa gaaagatgtt tatgtcgtag aattggattg gtatccggat   1380
gcccctggag aaatggtggt cctcacctgt gacacccctg aagaagatgg tatcacctgg   1440
accttggacc agagcagtga ggtcttaggc tctggcaaaa ccctgaccat ccaagtcaaa   1500
gagtttggag atgctggcca gtacacctgt cacaaaggag gcgaggttct aagccattcg   1560
ctcctgctgc ttcacaaaaa ggaagatgga atttggtcca ctgatatttt aaaggaccag   1620
aaagaaccca aaaataagac ctttctaaga tgcgaggcca agaattattc tggacgtttc   1680
acctgctggt ggctgacgac aatcagtact gatttgacat tcagtgtcaa aagcagcaga   1740
ggctcttctg acccccaagg ggtgacgtgc ggagctgcta cactctctgc agagagagtc   1800
agaggggaca acaaggagta tgagtactca gtggagtgcc aggaggacag tgcctgccca   1860
gctgctgagg agagtctgcc cattgaggtc atggtggatg ccgttcacaa gctcaagtat   1920
gaaaactaca ccagcagctt cttcatcagg gacatcatca aacctgaccc acccaagaac   1980
ttgcagctga agccattaaa gaattctcgg caggtggagg tcagctggga gtaccctgac   2040
acctggagta ctccacattc ctacttctcc ctgacattct gcgttcaggt ccagggcaag   2100
agcaagagag aaaagaaaga tagagtcttc acggacaaga cctcagccac ggtcatctgc   2160
cgcaaaaatg ccagcattag cgtgcgggcc caggaccgct actatagctc atcttggagc   2220
gaatgggcat ctgtgccctg cagtgagggc agaggcagcc tgctgacctg cggcgacgtc   2280
gaggagaacc ccgggcccat gggggcaggt gccaccggcc gcgccatgga cgggccgcgc   2340
ctgctgctgt tgctgcttct gggggtgtcc cttggaggtg ccaaggaggc atgccccaca   2400
ggcctgtaca cacacagcgg tgagtgctgc aaagcctgca acctgggcga gggtgtggcc   2460
cagccttgtg gagccaacca gaccgtgtgt gagccctgcc tggacagcgt gacgttctcc   2520
gacgtggtga gcgcgaccga gccgtgcaag ccgtgcaccg agtgcgtggg gctccagagc   2580
atgtcggcgc cgtgcgtgga ggccgatgac gccgtgtgcc gctgcgccta cggctactac   2640
caggatgaga cgactgggcg ctgcgaggcg tgccgcgtgt gcgaggcggg ctcgggcctc   2700
gtgttctcct gccaggacaa gcagaacacc gtgtgcgagg agtgccccga cggcacgtat   2760
tccgacgagg ccaaccacgt ggacccgtgc ctgccctgca ccgtgtgcga ggacaccgag   2820
cgccagctcc gcgagtgcac acgctgggcc gacgccgagt gcgaggagat ccctggccgt   2880
tggattacac ggtccacacc cccagagggc tcggacagca cagcccccag cacccaggag   2940
cctgaggcac ctccagaaca agacctcata gccagcacgg tggcaggtgt ggtgaccaca   3000
gtgatgggca gctcccagcc cgtggtgacc cgaggcacca ccgacaacct catccctgtc   3060
tattgctcca tcctggctgc tgtggttgtg ggtcttgtgg cctacatagc cttcaagagg   3120
tgaaaaacca aaagaacaag aatttcttgg taagaagccg ggaacagaca acagaagtca   3180
tgaagcccaa gtgaaatcaa aggtgctaaa tggtcgccca ggagacatcc gttgtgcttg   3240
cctgcgtttt ggaagctctg aagtcacatc acaggacacg gggcagtggc aaccttgtct   3300
ctatgccagc tcagtcccat cagagagcga gcgctaccca cttctaaata gcaatttcgc   3360
cgttgaagag gaagggcaaa accactagaa ctctccatct tattttcatg tatatgtgtt   3420
catgaatggt atggaactct ctccacccta tatgtagtat aaagaaaagt aggtt        3475


<210>  40

<211>  3759
<212>  DNA
<213>  artificial sequence

<220>
<223>  Inserted matrice  PD1 locus_IL12a_2A_IL12b (60 nucleotides upstream and downstream)

<400>  40
ggtggccggg gaggctttgt ggggccaccc agccccttcc tcacctctct ccatctctca     60
gactccccag acaggccctg gaaccccccc accttctccc cagccctgct cgtggtgacc    120
gaaggggaca acgccacctt cacctgcagc ttctccaaca catcggagag cttcgtgcta    180
aactggtacc gcatgagccc cagcaaccag acggacaagc tggccgcctt ccccgaggac    240
cgcagccagc ccggccagga ctgccgcttc cgtgtcacac aactgcccaa cgggcgtgac    300
ttccacatga gcgtggtcag ggcccggcgc aatgacagcg gcacctacct ctgtggggcc    360
ggttctggcg tgaaacagac tttgaatttt gaccttctca agttggcggg agacgtggag    420
tccaacccag ggcccatgtg gccccctggg tcagcctccc agccaccgcc ctcacctgcc    480
gcggccacag gtctgcatcc agcggctcgc cctgtgtccc tgcagtgccg gctcagcatg    540
tgtccagcgc gcagcctcct ccttgtggct accctggtcc tcctggacca cctcagtttg    600
gccagaaacc tccccgtggc cactccagac ccaggaatgt tcccatgcct tcaccactcc    660
caaaacctgc tgagggccgt cagcaacatg ctccagaagg ccagacaaac tctagaattt    720
tacccttgca cttctgaaga gattgatcat gaagatatca caaaagataa aaccagcaca    780
gtggaggcct gtttaccatt ggaattaacc aagaatgaga gttgcctaaa ttccagagag    840
acctctttca taactaatgg gagttgcctg gcctccagaa agacctcttt tatgatggcc    900
ctgtgcctta gtagtattta tgaagacttg aagatgtacc aggtggagtt caagaccatg    960
aatgcaaagc ttctgatgga tcctaagagg cagatctttc tagatcaaaa catgctggca   1020
gttattgatg agctgatgca ggccctgaat ttcaacagtg agactgtgcc acaaaaatcc   1080
tcccttgaag aaccggattt ttataaaact aaaatcaagc tctgcatact tcttcatgct   1140
ttcagaattc gggcagtgac tattgataga gtgatgagct atctgaatgc ttccggaagc   1200
ggagctacta acttcagcct gctgaagcag gctggagacg tggaggagaa ccctggacct   1260
atgtgtcacc agcagttggt catctcttgg ttttccctgg tttttctggc atctcccctc   1320
gtggccatat gggaactgaa gaaagatgtt tatgtcgtag aattggattg gtatccggat   1380
gcccctggag aaatggtggt cctcacctgt gacacccctg aagaagatgg tatcacctgg   1440
accttggacc agagcagtga ggtcttaggc tctggcaaaa ccctgaccat ccaagtcaaa   1500
gagtttggag atgctggcca gtacacctgt cacaaaggag gcgaggttct aagccattcg   1560
ctcctgctgc ttcacaaaaa ggaagatgga atttggtcca ctgatatttt aaaggaccag   1620
aaagaaccca aaaataagac ctttctaaga tgcgaggcca agaattattc tggacgtttc   1680
acctgctggt ggctgacgac aatcagtact gatttgacat tcagtgtcaa aagcagcaga   1740
ggctcttctg acccccaagg ggtgacgtgc ggagctgcta cactctctgc agagagagtc   1800
agaggggaca acaaggagta tgagtactca gtggagtgcc aggaggacag tgcctgccca   1860
gctgctgagg agagtctgcc cattgaggtc atggtggatg ccgttcacaa gctcaagtat   1920
gaaaactaca ccagcagctt cttcatcagg gacatcatca aacctgaccc acccaagaac   1980
ttgcagctga agccattaaa gaattctcgg caggtggagg tcagctggga gtaccctgac   2040
acctggagta ctccacattc ctacttctcc ctgacattct gcgttcaggt ccagggcaag   2100
agcaagagag aaaagaaaga tagagtcttc acggacaaga cctcagccac ggtcatctgc   2160
cgcaaaaatg ccagcattag cgtgcgggcc caggaccgct actatagctc atcttggagc   2220
gaatgggcat ctgtgccctg cagtgagggc agaggcagcc tgctgacctg cggcgacgtc   2280
gaggagaacc ccgggcccat gggggcaggt gccaccggcc gcgccatgga cgggccgcgc   2340
ctgctgctgt tgctgcttct gggggtgtcc cttggaggtg ccaaggaggc atgccccaca   2400
ggcctgtaca cacacagcgg tgagtgctgc aaagcctgca acctgggcga gggtgtggcc   2460
cagccttgtg gagccaacca gaccgtgtgt gagccctgcc tggacagcgt gacgttctcc   2520
gacgtggtga gcgcgaccga gccgtgcaag ccgtgcaccg agtgcgtggg gctccagagc   2580
atgtcggcgc cgtgcgtgga ggccgatgac gccgtgtgcc gctgcgccta cggctactac   2640
caggatgaga cgactgggcg ctgcgaggcg tgccgcgtgt gcgaggcggg ctcgggcctc   2700
gtgttctcct gccaggacaa gcagaacacc gtgtgcgagg agtgccccga cggcacgtat   2760
tccgacgagg ccaaccacgt ggacccgtgc ctgccctgca ccgtgtgcga ggacaccgag   2820
cgccagctcc gcgagtgcac acgctgggcc gacgccgagt gcgaggagat ccctggccgt   2880
tggattacac ggtccacacc cccagagggc tcggacagca cagcccccag cacccaggag   2940
cctgaggcac ctccagaaca agacctcata gccagcacgg tggcaggtgt ggtgaccaca   3000
gtgatgggca gctcccagcc cgtggtgacc cgaggcacca ccgacaacct catccctgtc   3060
tattgctcca tcctggctgc tgtggttgtg ggtcttgtgg cctacatagc cttcaagagg   3120
tgatctagag ggcccgttta aacccgctga tcagcctcga ctgtgccttc tagttgccag   3180
ccatctgttg tttgcccctc ccccgtgcct tccttgaccc tggaaggtgc cactcccact   3240
gtcctttcct aataaaatga ggaaattgca tcgcattgtc tgagtaggtg tcattctatt   3300
ctggggggtg gggtggggca ggacagcaag ggggaggatt gggaagacaa tagcaggcat   3360
gctggggatg cggtgggctc tatgactagt ggcgaattcg gcgcagatca aagagagcct   3420
gcgggcagag ctcagggtga caggtgcggc ctcggaggcc ccggggcagg ggtgagctga   3480
gccggtcctg gggtgggtgt cccctcctgc acaggatcag gagctccagg gtcgtagggc   3540
agggaccccc cagctccagt ccagggctct gtcctgcacc tggggaatgg tgaccggcat   3600
ctctgtcctc tagctctgga agcaccccag cccctctagt ctgccctcac ccctgaccct   3660
gaccctccac cctgaccccg tcctaacccc tgacctttgt gcccttccag agagaagggc   3720
agaagtgccc acagcccacc ccagcccctc acccaggcc                          3759


<210>  41

<211>  60
<212>  DNA
<213>  artificial sequence

<220>
<223>  upstream TRAC locus polynucleotide sequence

<400>  41
atgagatcat gtcctaaccc tgatcctctt gtcccacaga tatccagaac cctgaccctg     60


<210>  42

<211>  60
<212>  DNA
<213>  artificial sequence

<220>
<223>  downstream TRAC locus polynucleotide sequence

<400>  42
gaaacagtga gccttgttct ggcagtccag agaatgacac gggaaaaaag cagatgaaga     60


<210>  43

<211>  60
<212>  DNA
<213>  artificial sequence

<220>
<223>  upstream CD25 locus polynucleotide sequence

<400>  43
agtgctggct agaaaccaag tgctttactg catgcacatc atttagcaca gttagttgct     60


<210>  44

<211>  52
<212>  DNA
<213>  artificial sequence

<220>
<223>  downstream CD25 locus polynucleotide sequence

<400>  44
gaatggtatg gaactctctc caccctatat gtagtataaa gaaaagtagg tt             52


<210>  45

<211>  60
<212>  DNA
<213>  artificial sequence

<220>
<223>  upstream PD1 locus polynucleotide sequence

<400>  45
ggtggccggg gaggctttgt ggggccaccc agccccttcc tcacctctct ccatctctca     60


<210>  46

<211>  60
<212>  DNA
<213>  artificial sequence

<220>
<223>  downstream PD1 locus polynucleotide sequence

<400>  46
tgcccttcca gagagaaggg cagaagtgcc cacagcccac cccagcccct cacccaggcc     60


<210>  47

<211>  759
<212>  DNA
<213>  artificial sequence

<220>
<223>  IL-12a polynucleotide

<400>  47
atgtggcccc ctgggtcagc ctcccagcca ccgccctcac ctgccgcggc cacaggtctg     60
catccagcgg ctcgccctgt gtccctgcag tgccggctca gcatgtgtcc agcgcgcagc    120
ctcctccttg tggctaccct ggtcctcctg gaccacctca gtttggccag aaacctcccc    180
gtggccactc cagacccagg aatgttccca tgccttcacc actcccaaaa cctgctgagg    240
gccgtcagca acatgctcca gaaggccaga caaactctag aattttaccc ttgcacttct    300
gaagagattg atcatgaaga tatcacaaaa gataaaacca gcacagtgga ggcctgttta    360
ccattggaat taaccaagaa tgagagttgc ctaaattcca gagagacctc tttcataact    420
aatgggagtt gcctggcctc cagaaagacc tcttttatga tggccctgtg ccttagtagt    480
atttatgaag acttgaagat gtaccaggtg gagttcaaga ccatgaatgc aaagcttctg    540
atggatccta agaggcagat ctttctagat caaaacatgc tggcagttat tgatgagctg    600
atgcaggccc tgaatttcaa cagtgagact gtgccacaaa aatcctccct tgaagaaccg    660
gatttttata aaactaaaat caagctctgc atacttcttc atgctttcag aattcgggca    720
gtgactattg atagagtgat gagctatctg aatgcttcc                           759


<210>  48

<211>  984
<212>  DNA
<213>  artificial sequence

<220>
<223>  IL12b polynucleotide

<400>  48
atgtgtcacc agcagttggt catctcttgg ttttccctgg tttttctggc atctcccctc     60
gtggccatat gggaactgaa gaaagatgtt tatgtcgtag aattggattg gtatccggat    120
gcccctggag aaatggtggt cctcacctgt gacacccctg aagaagatgg tatcacctgg    180
accttggacc agagcagtga ggtcttaggc tctggcaaaa ccctgaccat ccaagtcaaa    240
gagtttggag atgctggcca gtacacctgt cacaaaggag gcgaggttct aagccattcg    300
ctcctgctgc ttcacaaaaa ggaagatgga atttggtcca ctgatatttt aaaggaccag    360
aaagaaccca aaaataagac ctttctaaga tgcgaggcca agaattattc tggacgtttc    420
acctgctggt ggctgacgac aatcagtact gatttgacat tcagtgtcaa aagcagcaga    480
ggctcttctg acccccaagg ggtgacgtgc ggagctgcta cactctctgc agagagagtc    540
agaggggaca acaaggagta tgagtactca gtggagtgcc aggaggacag tgcctgccca    600
gctgctgagg agagtctgcc cattgaggtc atggtggatg ccgttcacaa gctcaagtat    660
gaaaactaca ccagcagctt cttcatcagg gacatcatca aacctgaccc acccaagaac    720
ttgcagctga agccattaaa gaattctcgg caggtggagg tcagctggga gtaccctgac    780
acctggagta ctccacattc ctacttctcc ctgacattct gcgttcaggt ccagggcaag    840
agcaagagag aaaagaaaga tagagtcttc acggacaaga cctcagccac ggtcatctgc    900
cgcaaaaatg ccagcattag cgtgcgggcc caggaccgct actatagctc atcttggagc    960
gaatgggcat ctgtgccctg cagt                                           984


<210>  49

<211>  399
<212>  DNA
<213>  artificial sequence

<220>
<223>  IL15 polynucleotide

<400>  49
ggcattcatg tcttcatttt gggctgtttc agtgcagggc ttcctaaaac agaagccaac     60
tgggtgaatg taataagtga tttgaaaaaa attgaagatc ttattcaatc tatgcatatt    120
gatgctactt tatatacgga aagtgatgtt caccccagtt gcaaagtaac agcaatgaag    180
tgctttctct tggagttaca agttatttca cttgagtccg gagatgcaag tattcatgat    240
acagtagaaa atctgatcat cctagcaaac aacagtttgt cttctaatgg gaatgtaaca    300
gaatctggat gcaaagaatg tgaggaactg gaggaaaaaa atattaaaga atttttgcag    360
agttttgtac atattgtcca aatgttcatc aacacttct                           399


<210>  50

<211>  525
<212>  DNA
<213>  artificial sequence

<220>
<223>  sIL15ra polynucleotide

<400>  50
atcacgtgcc ctccccccat gtccgtggaa cacgcagaca tctgggtcaa gagctacagc     60
ttgtactcca gggagcggta catttgtaac tctggtttca agcgtaaagc cggcacgtcc    120
agcctgacgg agtgcgtgtt gaacaaggcc acgaatgtcg cccactggac aacccccagt    180
ctcaaatgca ttagagaccc tgccctggtt caccaaaggc cagcgccacc ctccacagta    240
acgacggcag gggtgacccc acagccagag agcctctccc cttctggaaa agagcccgca    300
gcttcatctc ccagctcaaa caacacagcg gccacaacag cagctattgt cccgggctcc    360
cagctgatgc cttcaaaatc accttccaca ggaaccacag agataagcag tcatgagtcc    420
tcccacggca ccccctctca gacaacagcc aagaactggg aactcacagc atccgcctcc    480
caccagccgc caggtgtgta tccacagggc cacagcgaca ccact                    525


<210>  51

<211>  1818
<212>  DNA
<213>  artificial sequence

<220>
<223>  soluble GP130 polynucleotide

<400>  51
atgctgacac tgcagacttg gctggtgcag gcactgttta tttttctgac tactgaatca     60
actggcgaac tgctggaccc ttgtggctac atcagccctg agtccccagt ggtgcagctg    120
cacagcaact tcaccgccgt gtgcgtgctg aaggagaagt gtatggacta ctttcacgtg    180
aacgccaatt atatcgtgtg gaaaaccaac cacttcacaa tccccaagga gcagtacacc    240
atcatcaata ggacagccag ctccgtgacc tttacagaca tcgcctccct gaacatccag    300
ctgacctgca atatcctgac attcggccag ctggagcaga acgtgtatgg catcaccatc    360
atctctggcc tgccccctga gaagcctaag aacctgagct gcatcgtgaa tgagggcaag    420
aagatgcggt gtgagtggga cggcggcaga gagacacacc tggagacaaa cttcaccctg    480
aagtccgagt gggccacaca caagtttgcc gactgcaagg ccaagcgcga taccccaaca    540
tcctgtaccg tggattactc tacagtgtat tttgtgaaca tcgaagtgtg ggtggaggcc    600
gagaatgccc tgggcaaggt gacctccgac cacatcaact tcgatcccgt gtacaaggtg    660
aagcctaacc caccccacaa tctgagcgtg atcaattccg aggagctgtc tagcatcctg    720
aagctgacct ggacaaaccc atctatcaag agcgtgatca tcctgaagta caatatccag    780
tatcggacca aggacgcctc cacatggagc cagatccctc cagaggatac cgccagcaca    840
agatcctctt tcaccgtgca ggacctgaag cccttcacag agtacgtgtt tcggatcaga    900
tgtatgaagg aggacggcaa gggctactgg agcgattggt ccgaggaggc cagcggcatc    960
acctatgagg acaggccttc taaggccccc agcttctggt acaagatcga tccatcccac   1020
acccagggct atcgcacagt gcagctggtg tggaaaaccc tgcccccttt cgaggccaac   1080
ggcaagatcc tggactacga ggtgaccctg acacggtgga agtcccacct gcagaactat   1140
accgtgaatg ccaccaagct gacagtgaac ctgacaaatg atcggtacct ggccaccctg   1200
acagtgagaa acctggtggg caagtctgac gccgccgtgc tgaccatccc tgcctgcgat   1260
ttccaggcca cacacccagt gatggacctg aaggcctttc ccaaggataa tatgctgtgg   1320
gtggagtgga ccacacctag agagtccgtg aagaagtaca tcctggagtg gtgcgtgctg   1380
tctgacaagg ccccatgtat caccgactgg cagcaggagg atggcaccgt gcacaggaca   1440
tatctgcgcg gcaacctggc cgagtctaag tgttacctga tcaccgtgac acccgtgtat   1500
gcagacggac caggctctcc tgagagcatc aaggcctacc tgaagcaggc accaccaagc   1560
aagggaccaa ccgtgcggac aaagaaggtc ggcaagaatg aggccgtgct ggagtgggac   1620
cagctgcctg tggatgtgca gaacggcttc atcaggaatt acaccatctt ttatcgcaca   1680
atcatcggca acgagacagc cgtgaatgtg gacagctccc acaccgagta tacactgtct   1740
agcctgacct ccgatacact gtacatggtg aggatggccg cctatacaga cgagggcggc   1800
aaggatggcc ccgagttt                                                 1818


<210>  52

<211>  72
<212>  DNA
<213>  artificial sequence

<220>
<223>  IgE signal sequence

<400>  52
ggtaccgggt ccgccaccat ggactggacc tggattctgt tcctcgtggc tgctgctaca     60
agagtgcaca gc                                                         72


<210>  53

<211>  75
<212>  DNA
<213>  artificial sequence

<220>
<223>  F2A

<400>  53
ggttctggcg tgaaacagac tttgaatttt gaccttctca agttggcggg agacgtggag     60
tccaacccag ggccc                                                      75


<210>  54

<211>  66
<212>  DNA
<213>  artificial sequence

<220>
<223>  P2A

<400>  54
ggaagcggag ctactaactt cagcctgctg aagcaggctg gagacgtgga ggagaaccct     60
ggacct                                                                66


<210>  55

<211>  54
<212>  DNA
<213>  artificial sequence

<220>
<223>  T2A

<400>  55
gagggcagag gcagcctgct gacctgcggc gacgtcgagg agaaccccgg gccc           54


<210>  56

<211>  825
<212>  DNA
<213>  artificial sequence

<220>
<223>  LNGFR

<400>  56
atgggggcag gtgccaccgg ccgcgccatg gacgggccgc gcctgctgct gttgctgctt     60
ctgggggtgt cccttggagg tgccaaggag gcatgcccca caggcctgta cacacacagc    120
ggtgagtgct gcaaagcctg caacctgggc gagggtgtgg cccagccttg tggagccaac    180
cagaccgtgt gtgagccctg cctggacagc gtgacgttct ccgacgtggt gagcgcgacc    240
gagccgtgca agccgtgcac cgagtgcgtg gggctccaga gcatgtcggc gccgtgcgtg    300
gaggccgatg acgccgtgtg ccgctgcgcc tacggctact accaggatga gacgactggg    360
cgctgcgagg cgtgccgcgt gtgcgaggcg ggctcgggcc tcgtgttctc ctgccaggac    420
aagcagaaca ccgtgtgcga ggagtgcccc gacggcacgt attccgacga ggccaaccac    480
gtggacccgt gcctgccctg caccgtgtgc gaggacaccg agcgccagct ccgcgagtgc    540
acacgctggg ccgacgccga gtgcgaggag atccctggcc gttggattac acggtccaca    600
cccccagagg gctcggacag cacagccccc agcacccagg agcctgaggc acctccagaa    660
caagacctca tagccagcac ggtggcaggt gtggtgacca cagtgatggg cagctcccag    720
cccgtggtga cccgaggcac caccgacaac ctcatccctg tctattgctc catcctggct    780
gctgtggttg tgggtcttgt ggcctacata gccttcaaga ggtga                    825


<210>  57

<211>  253
<212>  PRT
<213>  artificial sequence

<220>
<223>  IL-12a polypeptide

<400>  57
Met Trp Pro Pro Gly Ser Ala Ser Gln Pro Pro Pro Ser Pro Ala Ala 
1               5                   10                  15      


Ala Thr Gly Leu His Pro Ala Ala Arg Pro Val Ser Leu Gln Cys Arg 
            20                  25                  30          


Leu Ser Met Cys Pro Ala Arg Ser Leu Leu Leu Val Ala Thr Leu Val 
        35                  40                  45              


Leu Leu Asp His Leu Ser Leu Ala Arg Asn Leu Pro Val Ala Thr Pro 
    50                  55                  60                  


Asp Pro Gly Met Phe Pro Cys Leu His His Ser Gln Asn Leu Leu Arg 
65                  70                  75                  80  


Ala Val Ser Asn Met Leu Gln Lys Ala Arg Gln Thr Leu Glu Phe Tyr 
                85                  90                  95      


Pro Cys Thr Ser Glu Glu Ile Asp His Glu Asp Ile Thr Lys Asp Lys 
            100                 105                 110         


Thr Ser Thr Val Glu Ala Cys Leu Pro Leu Glu Leu Thr Lys Asn Glu 
        115                 120                 125             


Ser Cys Leu Asn Ser Arg Glu Thr Ser Phe Ile Thr Asn Gly Ser Cys 
    130                 135                 140                 


Leu Ala Ser Arg Lys Thr Ser Phe Met Met Ala Leu Cys Leu Ser Ser 
145                 150                 155                 160 


Ile Tyr Glu Asp Leu Lys Met Tyr Gln Val Glu Phe Lys Thr Met Asn 
                165                 170                 175     


Ala Lys Leu Leu Met Asp Pro Lys Arg Gln Ile Phe Leu Asp Gln Asn 
            180                 185                 190         


Met Leu Ala Val Ile Asp Glu Leu Met Gln Ala Leu Asn Phe Asn Ser 
        195                 200                 205             


Glu Thr Val Pro Gln Lys Ser Ser Leu Glu Glu Pro Asp Phe Tyr Lys 
    210                 215                 220                 


Thr Lys Ile Lys Leu Cys Ile Leu Leu His Ala Phe Arg Ile Arg Ala 
225                 230                 235                 240 


Val Thr Ile Asp Arg Val Met Ser Tyr Leu Asn Ala Ser 
                245                 250             


<210>  58

<211>  328
<212>  PRT
<213>  artificial sequence

<220>
<223>  IL12b polypeptide

<400>  58
Met Cys His Gln Gln Leu Val Ile Ser Trp Phe Ser Leu Val Phe Leu 
1               5                   10                  15      


Ala Ser Pro Leu Val Ala Ile Trp Glu Leu Lys Lys Asp Val Tyr Val 
            20                  25                  30          


Val Glu Leu Asp Trp Tyr Pro Asp Ala Pro Gly Glu Met Val Val Leu 
        35                  40                  45              


Thr Cys Asp Thr Pro Glu Glu Asp Gly Ile Thr Trp Thr Leu Asp Gln 
    50                  55                  60                  


Ser Ser Glu Val Leu Gly Ser Gly Lys Thr Leu Thr Ile Gln Val Lys 
65                  70                  75                  80  


Glu Phe Gly Asp Ala Gly Gln Tyr Thr Cys His Lys Gly Gly Glu Val 
                85                  90                  95      


Leu Ser His Ser Leu Leu Leu Leu His Lys Lys Glu Asp Gly Ile Trp 
            100                 105                 110         


Ser Thr Asp Ile Leu Lys Asp Gln Lys Glu Pro Lys Asn Lys Thr Phe 
        115                 120                 125             


Leu Arg Cys Glu Ala Lys Asn Tyr Ser Gly Arg Phe Thr Cys Trp Trp 
    130                 135                 140                 


Leu Thr Thr Ile Ser Thr Asp Leu Thr Phe Ser Val Lys Ser Ser Arg 
145                 150                 155                 160 


Gly Ser Ser Asp Pro Gln Gly Val Thr Cys Gly Ala Ala Thr Leu Ser 
                165                 170                 175     


Ala Glu Arg Val Arg Gly Asp Asn Lys Glu Tyr Glu Tyr Ser Val Glu 
            180                 185                 190         


Cys Gln Glu Asp Ser Ala Cys Pro Ala Ala Glu Glu Ser Leu Pro Ile 
        195                 200                 205             


Glu Val Met Val Asp Ala Val His Lys Leu Lys Tyr Glu Asn Tyr Thr 
    210                 215                 220                 


Ser Ser Phe Phe Ile Arg Asp Ile Ile Lys Pro Asp Pro Pro Lys Asn 
225                 230                 235                 240 


Leu Gln Leu Lys Pro Leu Lys Asn Ser Arg Gln Val Glu Val Ser Trp 
                245                 250                 255     


Glu Tyr Pro Asp Thr Trp Ser Thr Pro His Ser Tyr Phe Ser Leu Thr 
            260                 265                 270         


Phe Cys Val Gln Val Gln Gly Lys Ser Lys Arg Glu Lys Lys Asp Arg 
        275                 280                 285             


Val Phe Thr Asp Lys Thr Ser Ala Thr Val Ile Cys Arg Lys Asn Ala 
    290                 295                 300                 


Ser Ile Ser Val Arg Ala Gln Asp Arg Tyr Tyr Ser Ser Ser Trp Ser 
305                 310                 315                 320 


Glu Trp Ala Ser Val Pro Cys Ser 
                325             


 
                245                 250             


<210>  59

<211>  133
<212>  PRT
<213>  artificial sequence

<220>
<223>  IL15 polypeptide

<400>  59
Gly Ile His Val Phe Ile Leu Gly Cys Phe Ser Ala Gly Leu Pro Lys 
1               5                   10                  15      


Thr Glu Ala Asn Trp Val Asn Val Ile Ser Asp Leu Lys Lys Ile Glu 
            20                  25                  30          


Asp Leu Ile Gln Ser Met His Ile Asp Ala Thr Leu Tyr Thr Glu Ser 
        35                  40                  45              


Asp Val His Pro Ser Cys Lys Val Thr Ala Met Lys Cys Phe Leu Leu 
    50                  55                  60                  


Glu Leu Gln Val Ile Ser Leu Glu Ser Gly Asp Ala Ser Ile His Asp 
65                  70                  75                  80  


Thr Val Glu Asn Leu Ile Ile Leu Ala Asn Asn Ser Leu Ser Ser Asn 
                85                  90                  95      


Gly Asn Val Thr Glu Ser Gly Cys Lys Glu Cys Glu Glu Leu Glu Glu 
            100                 105                 110         


Lys Asn Ile Lys Glu Phe Leu Gln Ser Phe Val His Ile Val Gln Met 
        115                 120                 125             


Phe Ile Asn Thr Ser 
    130             


<210>  60

<211>  175
<212>  PRT
<213>  artificial sequence

<220>
<223>  sIL15ra polypeptide

<400>  60
Ile Thr Cys Pro Pro Pro Met Ser Val Glu His Ala Asp Ile Trp Val 
1               5                   10                  15      


Lys Ser Tyr Ser Leu Tyr Ser Arg Glu Arg Tyr Ile Cys Asn Ser Gly 
            20                  25                  30          


Phe Lys Arg Lys Ala Gly Thr Ser Ser Leu Thr Glu Cys Val Leu Asn 
        35                  40                  45              


Lys Ala Thr Asn Val Ala His Trp Thr Thr Pro Ser Leu Lys Cys Ile 
    50                  55                  60                  


Arg Asp Pro Ala Leu Val His Gln Arg Pro Ala Pro Pro Ser Thr Val 
65                  70                  75                  80  


Thr Thr Ala Gly Val Thr Pro Gln Pro Glu Ser Leu Ser Pro Ser Gly 
                85                  90                  95      


Lys Glu Pro Ala Ala Ser Ser Pro Ser Ser Asn Asn Thr Ala Ala Thr 
            100                 105                 110         


Thr Ala Ala Ile Val Pro Gly Ser Gln Leu Met Pro Ser Lys Ser Pro 
        115                 120                 125             


Ser Thr Gly Thr Thr Glu Ile Ser Ser His Glu Ser Ser His Gly Thr 
    130                 135                 140                 


Pro Ser Gln Thr Thr Ala Lys Asn Trp Glu Leu Thr Ala Ser Ala Ser 
145                 150                 155                 160 


His Gln Pro Pro Gly Val Tyr Pro Gln Gly His Ser Asp Thr Thr 
                165                 170                 175 


<210>  61

<211>  606
<212>  PRT
<213>  artificial sequence

<220>
<223>  soluble gp130

<400>  61
Met Leu Thr Leu Gln Thr Trp Leu Val Gln Ala Leu Phe Ile Phe Leu 
1               5                   10                  15      


Thr Thr Glu Ser Thr Gly Glu Leu Leu Asp Pro Cys Gly Tyr Ile Ser 
            20                  25                  30          


Pro Glu Ser Pro Val Val Gln Leu His Ser Asn Phe Thr Ala Val Cys 
        35                  40                  45              


Val Leu Lys Glu Lys Cys Met Asp Tyr Phe His Val Asn Ala Asn Tyr 
    50                  55                  60                  


Ile Val Trp Lys Thr Asn His Phe Thr Ile Pro Lys Glu Gln Tyr Thr 
65                  70                  75                  80  


Ile Ile Asn Arg Thr Ala Ser Ser Val Thr Phe Thr Asp Ile Ala Ser 
                85                  90                  95      


Leu Asn Ile Gln Leu Thr Cys Asn Ile Leu Thr Phe Gly Gln Leu Glu 
            100                 105                 110         


Gln Asn Val Tyr Gly Ile Thr Ile Ile Ser Gly Leu Pro Pro Glu Lys 
        115                 120                 125             


Pro Lys Asn Leu Ser Cys Ile Val Asn Glu Gly Lys Lys Met Arg Cys 
    130                 135                 140                 


Glu Trp Asp Gly Gly Arg Glu Thr His Leu Glu Thr Asn Phe Thr Leu 
145                 150                 155                 160 


Lys Ser Glu Trp Ala Thr His Lys Phe Ala Asp Cys Lys Ala Lys Arg 
                165                 170                 175     


Asp Thr Pro Thr Ser Cys Thr Val Asp Tyr Ser Thr Val Tyr Phe Val 
            180                 185                 190         


Asn Ile Glu Val Trp Val Glu Ala Glu Asn Ala Leu Gly Lys Val Thr 
        195                 200                 205             


Ser Asp His Ile Asn Phe Asp Pro Val Tyr Lys Val Lys Pro Asn Pro 
    210                 215                 220                 


Pro His Asn Leu Ser Val Ile Asn Ser Glu Glu Leu Ser Ser Ile Leu 
225                 230                 235                 240 


Lys Leu Thr Trp Thr Asn Pro Ser Ile Lys Ser Val Ile Ile Leu Lys 
                245                 250                 255     


Tyr Asn Ile Gln Tyr Arg Thr Lys Asp Ala Ser Thr Trp Ser Gln Ile 
            260                 265                 270         


Pro Pro Glu Asp Thr Ala Ser Thr Arg Ser Ser Phe Thr Val Gln Asp 
        275                 280                 285             


Leu Lys Pro Phe Thr Glu Tyr Val Phe Arg Ile Arg Cys Met Lys Glu 
    290                 295                 300                 


Asp Gly Lys Gly Tyr Trp Ser Asp Trp Ser Glu Glu Ala Ser Gly Ile 
305                 310                 315                 320 


Thr Tyr Glu Asp Arg Pro Ser Lys Ala Pro Ser Phe Trp Tyr Lys Ile 
                325                 330                 335     


Asp Pro Ser His Thr Gln Gly Tyr Arg Thr Val Gln Leu Val Trp Lys 
            340                 345                 350         


Thr Leu Pro Pro Phe Glu Ala Asn Gly Lys Ile Leu Asp Tyr Glu Val 
        355                 360                 365             


Thr Leu Thr Arg Trp Lys Ser His Leu Gln Asn Tyr Thr Val Asn Ala 
    370                 375                 380                 


Thr Lys Leu Thr Val Asn Leu Thr Asn Asp Arg Tyr Leu Ala Thr Leu 
385                 390                 395                 400 


Thr Val Arg Asn Leu Val Gly Lys Ser Asp Ala Ala Val Leu Thr Ile 
                405                 410                 415     


Pro Ala Cys Asp Phe Gln Ala Thr His Pro Val Met Asp Leu Lys Ala 
            420                 425                 430         


Phe Pro Lys Asp Asn Met Leu Trp Val Glu Trp Thr Thr Pro Arg Glu 
        435                 440                 445             


Ser Val Lys Lys Tyr Ile Leu Glu Trp Cys Val Leu Ser Asp Lys Ala 
    450                 455                 460                 


Pro Cys Ile Thr Asp Trp Gln Gln Glu Asp Gly Thr Val His Arg Thr 
465                 470                 475                 480 


Tyr Leu Arg Gly Asn Leu Ala Glu Ser Lys Cys Tyr Leu Ile Thr Val 
                485                 490                 495     


Thr Pro Val Tyr Ala Asp Gly Pro Gly Ser Pro Glu Ser Ile Lys Ala 
            500                 505                 510         


Tyr Leu Lys Gln Ala Pro Pro Ser Lys Gly Pro Thr Val Arg Thr Lys 
        515                 520                 525             


Lys Val Gly Lys Asn Glu Ala Val Leu Glu Trp Asp Gln Leu Pro Val 
    530                 535                 540                 


Asp Val Gln Asn Gly Phe Ile Arg Asn Tyr Thr Ile Phe Tyr Arg Thr 
545                 550                 555                 560 


Ile Ile Gly Asn Glu Thr Ala Val Asn Val Asp Ser Ser His Thr Glu 
                565                 570                 575     


Tyr Thr Leu Ser Ser Leu Thr Ser Asp Thr Leu Tyr Met Val Arg Met 
            580                 585                 590         


Ala Ala Tyr Thr Asp Glu Gly Gly Lys Asp Gly Pro Glu Phe 
        595                 600                 605     


<210>  62

<211>  836
<212>  PRT
<213>  artificial sequence

<220>
<223>  soluble gp130 fused to a Fc

<400>  62
Met Leu Thr Leu Gln Thr Trp Leu Val Gln Ala Leu Phe Ile Phe Leu 
1               5                   10                  15      


Thr Thr Glu Ser Thr Gly Glu Leu Leu Asp Pro Cys Gly Tyr Ile Ser 
            20                  25                  30          


Pro Glu Ser Pro Val Val Gln Leu His Ser Asn Phe Thr Ala Val Cys 
        35                  40                  45              


Val Leu Lys Glu Lys Cys Met Asp Tyr Phe His Val Asn Ala Asn Tyr 
    50                  55                  60                  


Ile Val Trp Lys Thr Asn His Phe Thr Ile Pro Lys Glu Gln Tyr Thr 
65                  70                  75                  80  


Ile Ile Asn Arg Thr Ala Ser Ser Val Thr Phe Thr Asp Ile Ala Ser 
                85                  90                  95      


Leu Asn Ile Gln Leu Thr Cys Asn Ile Leu Thr Phe Gly Gln Leu Glu 
            100                 105                 110         


Gln Asn Val Tyr Gly Ile Thr Ile Ile Ser Gly Leu Pro Pro Glu Lys 
        115                 120                 125             


Pro Lys Asn Leu Ser Cys Ile Val Asn Glu Gly Lys Lys Met Arg Cys 
    130                 135                 140                 


Glu Trp Asp Gly Gly Arg Glu Thr His Leu Glu Thr Asn Phe Thr Leu 
145                 150                 155                 160 


Lys Ser Glu Trp Ala Thr His Lys Phe Ala Asp Cys Lys Ala Lys Arg 
                165                 170                 175     


Asp Thr Pro Thr Ser Cys Thr Val Asp Tyr Ser Thr Val Tyr Phe Val 
            180                 185                 190         


Asn Ile Glu Val Trp Val Glu Ala Glu Asn Ala Leu Gly Lys Val Thr 
        195                 200                 205             


Ser Asp His Ile Asn Phe Asp Pro Val Tyr Lys Val Lys Pro Asn Pro 
    210                 215                 220                 


Pro His Asn Leu Ser Val Ile Asn Ser Glu Glu Leu Ser Ser Ile Leu 
225                 230                 235                 240 


Lys Leu Thr Trp Thr Asn Pro Ser Ile Lys Ser Val Ile Ile Leu Lys 
                245                 250                 255     


Tyr Asn Ile Gln Tyr Arg Thr Lys Asp Ala Ser Thr Trp Ser Gln Ile 
            260                 265                 270         


Pro Pro Glu Asp Thr Ala Ser Thr Arg Ser Ser Phe Thr Val Gln Asp 
        275                 280                 285             


Leu Lys Pro Phe Thr Glu Tyr Val Phe Arg Ile Arg Cys Met Lys Glu 
    290                 295                 300                 


Asp Gly Lys Gly Tyr Trp Ser Asp Trp Ser Glu Glu Ala Ser Gly Ile 
305                 310                 315                 320 


Thr Tyr Glu Asp Arg Pro Ser Lys Ala Pro Ser Phe Trp Tyr Lys Ile 
                325                 330                 335     


Asp Pro Ser His Thr Gln Gly Tyr Arg Thr Val Gln Leu Val Trp Lys 
            340                 345                 350         


Thr Leu Pro Pro Phe Glu Ala Asn Gly Lys Ile Leu Asp Tyr Glu Val 
        355                 360                 365             


Thr Leu Thr Arg Trp Lys Ser His Leu Gln Asn Tyr Thr Val Asn Ala 
    370                 375                 380                 


Thr Lys Leu Thr Val Asn Leu Thr Asn Asp Arg Tyr Leu Ala Thr Leu 
385                 390                 395                 400 


Thr Val Arg Asn Leu Val Gly Lys Ser Asp Ala Ala Val Leu Thr Ile 
                405                 410                 415     


Pro Ala Cys Asp Phe Gln Ala Thr His Pro Val Met Asp Leu Lys Ala 
            420                 425                 430         


Phe Pro Lys Asp Asn Met Leu Trp Val Glu Trp Thr Thr Pro Arg Glu 
        435                 440                 445             


Ser Val Lys Lys Tyr Ile Leu Glu Trp Cys Val Leu Ser Asp Lys Ala 
    450                 455                 460                 


Pro Cys Ile Thr Asp Trp Gln Gln Glu Asp Gly Thr Val His Arg Thr 
465                 470                 475                 480 


Tyr Leu Arg Gly Asn Leu Ala Glu Ser Lys Cys Tyr Leu Ile Thr Val 
                485                 490                 495     


Thr Pro Val Tyr Ala Asp Gly Pro Gly Ser Pro Glu Ser Ile Lys Ala 
            500                 505                 510         


Tyr Leu Lys Gln Ala Pro Pro Ser Lys Gly Pro Thr Val Arg Thr Lys 
        515                 520                 525             


Lys Val Gly Lys Asn Glu Ala Val Leu Glu Trp Asp Gln Leu Pro Val 
    530                 535                 540                 


Asp Val Gln Asn Gly Phe Ile Arg Asn Tyr Thr Ile Phe Tyr Arg Thr 
545                 550                 555                 560 


Ile Ile Gly Asn Glu Thr Ala Val Asn Val Asp Ser Ser His Thr Glu 
                565                 570                 575     


Tyr Thr Leu Ser Ser Leu Thr Ser Asp Thr Leu Tyr Met Val Arg Met 
            580                 585                 590         


Ala Ala Tyr Thr Asp Glu Gly Gly Lys Asp Gly Pro Glu Phe Arg Ser 
        595                 600                 605             


Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Ala Glu 
    610                 615                 620                 


Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu 
625                 630                 635                 640 


Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser 
                645                 650                 655     


His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu 
            660                 665                 670         


Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr 
        675                 680                 685             


Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn 
    690                 695                 700                 


Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro 
705                 710                 715                 720 


Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln 
                725                 730                 735     


Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val 
            740                 745                 750         


Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val 
        755                 760                 765             


Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro 
    770                 775                 780                 


Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr 
785                 790                 795                 800 


Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val 
                805                 810                 815     


Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu 
            820                 825                 830         


Ser Pro Gly Lys 
        835     




<210>  63

<211>  7711
<212>  DNA
<213>  artificial sequence

<220>
<223>  Matrice TRAC locus_CubiCAR CD22 pCLS30056 full sequence

<400>  63
gtggcacttt tcggggaaat gtgcgcggaa cccctatttg tttatttttc taaatacatt     60
caaatatgta tccgctcatg agacaataac cctgataaat gcttcaataa tattgaaaaa    120
ggaagagtat gagtattcaa catttccgtg tcgcccttat tccctttttt gcggcatttt    180
gccttcctgt ttttgctcac ccagaaacgc tggtgaaagt aaaagatgct gaagatcagt    240
tgggtgcacg agtgggttac atcgaactgg atctcaacag cggtaagatc cttgagagtt    300
ttcgccccga agaacgtttt ccaatgatga gcacttttaa agttctgcta tgtggcgcgg    360
tattatcccg tattgacgcc gggcaagagc aactcggtcg ccgcatacac tattctcaga    420
atgacttggt tgagtactca ccagtcacag aaaagcatct tacggatggc atgacagtaa    480
gagaattatg cagtgctgcc ataaccatga gtgataacac tgcggccaac ttacttctga    540
caacgatcgg aggaccgaag gagctaaccg cttttttgca caacatgggg gatcatgtaa    600
ctcgccttga tcgttgggaa ccggagctga atgaagccat accaaacgac gagcgtgaca    660
ccacgatgcc tgtagcaatg gcaacaacgt tgcgcaaact attaactggc gaactactta    720
ctctagcttc ccggcaacaa ttaatagact ggatggaggc ggataaagtt gcaggaccac    780
ttctgcgctc ggcccttccg gctggctggt ttattgctga taaatctgga gccggtgagc    840
gtggttctcg cggtatcatt gcagcactgg ggccagatgg taagccctcc cgtatcgtag    900
ttatctacac gacggggagt caggcaacta tggatgaacg aaatagacag atcgctgaga    960
taggtgcctc actgattaag cattggtaac tgtcagacca agtttactca tatatacttt   1020
agattgattt aaaacttcat ttttaattta aaaggatcta ggtgaagatc ctttttgata   1080
atctcatgac caaaatccct taacgtgagt tttcgttcca ctgagcgtca gaccccgtag   1140
aaaagatcaa aggatcttct tgagatcctt tttttctgcg cgtaatctgc tgcttgcaaa   1200
caaaaaaacc accgctacca gcggtggttt gtttgccgga tcaagagcta ccaactcttt   1260
ttccgaaggt aactggcttc agcagagcgc agataccaaa tactgttctt ctagtgtagc   1320
cgtagttagg ccaccacttc aagaactctg tagcaccgcc tacatacctc gctctgctaa   1380
tcctgttacc agtggctgct gccagtggcg ataagtcgtg tcttaccggg ttggactcaa   1440
gacgatagtt accggataag gcgcagcggt cgggctgaac ggggggttcg tgcacacagc   1500
ccagcttgga gcgaacgacc tacaccgaac tgagatacct acagcgtgag ctatgagaaa   1560
gcgccacgct tcccgaaggg agaaaggcgg acaggtatcc ggtaagcggc agggtcggaa   1620
caggagagcg cacgagggag cttccagggg gaaacgcctg gtatctttat agtcctgtcg   1680
ggtttcgcca cctctgactt gagcgtcgat ttttgtgatg ctcgtcaggg gggcggagcc   1740
tatggaaaaa cgccagcaac gcggcctttt tacggttcct ggccttttgc tggccttttg   1800
ctcacatggt ctttcctgcg ttatcccctg attctgtgga taaccgtatt accgcctttg   1860
agtgagctga taccgctcgc cgcagccgaa cgaccgagcg cagcgagtca gtgagcgagg   1920
aagcggagag cgcccaatac gcaaaccgcc tctccccgcg cgttggccga ttcattaatg   1980
cagctggcac gacaggtttc ccgactggaa agcgggcagt gagcgcaacg caattaatgt   2040
gagttagctc actcattagg caccccaggc tttacacttt atgcttccgg ctcgtatgtt   2100
gtgtggaatt gtgagcggat aacaatttca cacaggaaac agctatgacc atgattacgc   2160
caagcgcgtc aattaaccct cactaaaggg aacaaaagct gttaattaat tgctgggcct   2220
ttttcccatg cctgccttta ctctgccaga gttatattgc tggggttttg aagaagatcc   2280
tattaaataa aagaataagc agtattatta agtagccctg catttcaggt ttccttgagt   2340
ggcaggccag gcctggccgt gaacgttcac tgaaatcatg gcctcttggc caagattgat   2400
agcttgtgcc tgtccctgag tcccagtcca tcacgagcag ctggtttcta agatgctatt   2460
tcccgtataa agcatgagac cgtgacttgc cagccccaca gagccccgcc cttgtccatc   2520
actggcatct ggactccagc ctgggttggg gcaaagaggg aaatgagatc atgtcctaac   2580
cctgatcctc ttgtcccaca gatatccagt acccctacga cgtgcccgac tacgcctccg   2640
gtgagggcag aggaagtctt ctaacatgcg gtgacgtgga ggagaatccg ggccccggat   2700
ccgctctgcc cgtcaccgct ctgctgctgc cactggcact gctgctgcac gctgctaggc   2760
ccggaggggg aggcagctgc ccctacagca accccagcct gtgcagcgga ggcggcggca   2820
gcggcggagg gggtagccag gtgcagctgc agcagagcgg ccctggcctg gtgaagccaa   2880
gccagacact gtccctgacc tgcgccatca gcggcgattc cgtgagctcc aactccgccg   2940
cctggaattg gatcaggcag tccccttctc ggggcctgga gtggctggga aggacatact   3000
atcggtctaa gtggtacaac gattatgccg tgtctgtgaa gagcagaatc acaatcaacc   3060
ctgacacctc caagaatcag ttctctctgc agctgaatag cgtgacacca gaggacaccg   3120
ccgtgtacta ttgcgccagg gaggtgaccg gcgacctgga ggatgccttt gacatctggg   3180
gccagggcac aatggtgacc gtgagctccg gaggcggcgg atctggcgga ggaggaagtg   3240
ggggcggcgg gagtgatatc cagatgacac agtccccatc ctctctgagc gcctccgtgg   3300
gcgacagagt gacaatcacc tgtagggcct cccagaccat ctggtcttac ctgaactggt   3360
atcagcagag gcccggcaag gcccctaatc tgctgatcta cgcagcaagc tccctgcaga   3420
gcggagtgcc atccagattc tctggcaggg gctccggcac agacttcacc ctgaccatct   3480
ctagcctgca ggccgaggac ttcgccacct actattgcca gcagtcttat agcatccccc   3540
agacatttgg ccagggcacc aagctggaga tcaagtcgga tcccggaagc ggagggggag   3600
gcagctgccc ctacagcaac cccagcctgt gcagcggagg cggcggcagc gagctgccca   3660
cccagggcac cttctccaac gtgtccacca acgtgagccc agccaagccc accaccaccg   3720
cctgtcctta ttccaatcct tccctgtgtg ctcccaccac aacccccgct ccaaggcccc   3780
ctacccccgc accaactatt gcctcccagc cactctcact gcggcctgag gcctgtcggc   3840
ccgctgctgg aggcgcagtg catacaaggg gcctcgattt cgcctgcgat atttacatct   3900
gggcacccct cgccggcacc tgcggggtgc ttctcctctc cctggtgatt accctgtatt   3960
gcagacgggg ccggaagaag ctcctctaca tttttaagca gcctttcatg cggccagtgc   4020
agacaaccca agaggaggat gggtgttcct gcagattccc tgaggaagag gaaggcgggt   4080
gcgagctgag agtgaagttc tccaggagcg cagatgcccc cgcctatcaa cagggccaga   4140
accagctcta caacgagctt aacctcggga ggcgcgaaga atacgacgtg ttggataaga   4200
gaagggggcg ggaccccgag atgggaggaa agccccggag gaagaaccct caggagggcc   4260
tgtacaacga gctgcagaag gataagatgg ccgaggccta ctcagagatc gggatgaagg   4320
gggagcggcg ccgcgggaag gggcacgatg ggctctacca ggggctgagc acagccacaa   4380
aggacacata cgacgccttg cacatgcagg cccttccacc ccgggaatag tctagagggc   4440
ccgtttaaac ccgctgatca gcctcgactg tgccttctag ttgccagcca tctgttgttt   4500
gcccctcccc cgtgccttcc ttgaccctgg aaggtgccac tcccactgtc ctttcctaat   4560
aaaatgagga aattgcatcg cattgtctga gtaggtgtca ttctattctg gggggtgggg   4620
tggggcagga cagcaagggg gaggattggg aagacaatag caggcatgct ggggatgcgg   4680
tgggctctat gactagtggc gaattcccgt gtaccagctg agagactcta aatccagtga   4740
caagtctgtc tgcctattca ccgattttga ttctcaaaca aatgtgtcac aaagtaagga   4800
ttctgatgtg tatatcacag acaaaactgt gctagacatg aggtctatgg acttcaagag   4860
caacagtgct gtggcctgga gcaacaaatc tgactttgca tgtgcaaacg ccttcaacaa   4920
cagcattatt ccagaagaca ccttcttccc cagcccaggt aagggcagct ttggtgcctt   4980
cgcaggctgt ttccttgctt caggaatggc caggttctgc ccagagctct ggtcaatgat   5040
gtctaaaact cctctgattg gtggtctcgg ccttatccat tgccaccaaa accctctttt   5100
tactaagcga tcgctccggt gcccgtcagt gggcagagcg cacatcgccc acagtccccg   5160
agaagttggg gggaggggtc ggcaattgaa cgggtgccta gagaaggtgg cgcggggtaa   5220
actgggaaag tgatgtcgtg tactggctcc gcctttttcc cgagggtggg ggagaaccgt   5280
atataagtgc agtagtcgcc gtgaacgttc tttttcgcaa cgggtttgcc gccagaacac   5340
agctgaagct tcgaggggct cgcatctctc cttcacgcgc ccgccgccct acctgaggcc   5400
gccatccacg ccggttgagt cgcgttctgc cgcctcccgc ctgtggtgcc tcctgaactg   5460
cgtccgccgt ctaggtaagt ttaaagctca ggtcgagacc gggcctttgt ccggcgctcc   5520
cttggagcct acctagactc agccggctct ccacgctttg cctgaccctg cttgctcaac   5580
tctacgtctt tgtttcgttt tctgttctgc gccgttacag atccaagctg tgaccggcgc   5640
ctacctgaga tcaccggcgc caccatggct tcttaccctg gacaccagca tgcttctgcc   5700
tttgaccagg ctgccagatc caggggccac tccaacagga gaactgccct aagacccaga   5760
agacagcagg aagccactga ggtgaggcct gagcagaaga tgccaaccct gctgagggtg   5820
tacattgatg gacctcatgg catgggcaag accaccacca ctcaactgct ggtggcactg   5880
ggctccaggg atgacattgt gtatgtgcct gagccaatga cctactggag agtgctagga   5940
gcctctgaga ccattgccaa catctacacc acccagcaca ggctggacca gggagaaatc   6000
tctgctggag atgctgctgt ggtgatgacc tctgcccaga tcacaatggg aatgccctat   6060
gctgtgactg atgctgttct ggctcctcac attggaggag aggctggctc ttctcatgcc   6120
cctccacctg ccctgaccct gatctttgac agacacccca ttgcagccct gctgtgctac   6180
ccagcagcaa ggtacctcat gggctccatg accccacagg ctgtgctggc ttttgtggcc   6240
ctgatccctc caaccctccc tggcaccaac attgttctgg gagcactgcc tgaagacaga   6300
cacattgaca ggctggcaaa gaggcagaga cctggagaga gactggacct ggccatgctg   6360
gctgcaatca gaagggtgta tggactgctg gcaaacactg tgagatacct ccagtgtgga   6420
ggctcttgga gagaggactg gggacagctc tctggaacag cagtgccccc tcaaggagct   6480
gagccccagt ccaatgctgg tccaagaccc cacattgggg acaccctgtt caccctgttc   6540
agagcccctg agctgctggc tcccaatgga gacctgtaca atgtgtttgc ctgggctctg   6600
gatgttctag ccaagaggct gaggtccatg catgtgttca tcctggacta tgaccagtcc   6660
cctgctggat gcagagatgc tctgctgcaa ctaacctctg gcatggtgca gacccatgtg   6720
accacccctg gcagcatccc caccatctgt gacctagcca gaacctttgc cagggagatg   6780
ggagaggcca actaaggcgc gccactcgag cgctagctgg ccagacatga taagatacat   6840
tgatgagttt ggacaaacca caactagaat gcagtgaaaa aaatgcttta tttgtgaaat   6900
ttgtgatgct attgctttat ttgtaaccat tataagctgc aataaacaag ttaacaacaa   6960
caattgcatt cattttatgt ttcaggttca gggggaggtg tgggaggttt tttaaagcaa   7020
gtaaaacctc tacaaatgtg gtatggaagg cgcgcccaat tcgccctata gtgagtcgta   7080
ttacgtcgcg ctcactggcc gtcgttttac aacgtcgtga ctgggaaaac cctggcgtta   7140
cccaacttaa tcgccttgca gcacatcccc ctttcgccag ctggcgtaat agcgaagagg   7200
cccgcaccga aacgcccttc ccaacagttg cgcagcctga atggcgaatg ggagcgccct   7260
gtagcggcgc attaagcgcg gcgggtgtgg tggttacgcg cagcgtgacc gctacacttg   7320
ccagcgccct agcgcccgct cctttcgctt tcttcccttc ctttctcgcc acgttcgccg   7380
gctttccccg tcaagctcta aatcgggggc tccctttagg gttccgattt agtgctttac   7440
ggcacctcga ccccaaaaaa cttgattagg gtgatggttg gcctgtagtg ggccatagcc   7500
ctgatagacg gtttttcgcc ctttgacgtt ggagtccacg ttctttaata gtggactctt   7560
gttccaaact ggaacaacac tcaaccctat ctcggtctat tcttttgatt tataagggat   7620
tttgccgatt tcggcctatt ggttaaaaaa tgagctgatt taacaaaaat ttaacgcgaa   7680
ttttaacaaa atattaacgc ttacaattta g                                  7711


<210>  64

<211>  7502
<212>  DNA
<213>  artificial sequence

<220>
<223>  Matrice CD25 locus_IL15_2A_sIL15Ra pCLS30519 full sequence

<400>  64
gtttattatt cctgttccac agctattgtc tgccatataa aaacttaggc caggcacagt     60
ggctcacacc tgtaatccca gcactttgga aggccgaggc aggcagatca caaggtcagg    120
agttcgagac cagcctggcc aacatagcaa aaccccatct ctactaaaaa tacaaaaatt    180
agccaggcat ggtggcgtgt gcactggttt agagtgagga ccacattttt ttggtgccgt    240
gttacacata tgaccgtgac tttgttacac cactacagga ggaagagtag aagaacaatc    300
ggttctggcg tgaaacagac tttgaatttt gaccttctca agttggcggg agacgtggag    360
tccaacccag ggcccggtac cgggtccgcc accatggact ggacctggat tctgttcctc    420
gtggctgctg ctacaagagt gcacagcggc attcatgtct tcattttggg ctgtttcagt    480
gcagggcttc ctaaaacaga agccaactgg gtgaatgtaa taagtgattt gaaaaaaatt    540
gaagatctta ttcaatctat gcatattgat gctactttat atacggaaag tgatgttcac    600
cccagttgca aagtaacagc aatgaagtgc tttctcttgg agttacaagt tatttcactt    660
gagtccggag atgcaagtat tcatgataca gtagaaaatc tgatcatcct agcaaacaac    720
agtttgtctt ctaatgggaa tgtaacagaa tctggatgca aagaatgtga ggaactggag    780
gaaaaaaata ttaaagaatt tttgcagagt tttgtacata ttgtccaaat gttcatcaac    840
acttctggaa gcggagctac taacttcagc ctgctgaagc aggctggaga cgtggaggag    900
aaccctggac ctgggaccgg ctctgcaacc atggattgga cgtggatcct gtttctcgtg    960
gcagctgcca caagagttca cagtatcacg tgccctcccc ccatgtccgt ggaacacgca   1020
gacatctggg tcaagagcta cagcttgtac tccagggagc ggtacatttg taactctggt   1080
ttcaagcgta aagccggcac gtccagcctg acggagtgcg tgttgaacaa ggccacgaat   1140
gtcgcccact ggacaacccc cagtctcaaa tgcattagag accctgccct ggttcaccaa   1200
aggccagcgc caccctccac agtaacgacg gcaggggtga ccccacagcc agagagcctc   1260
tccccttctg gaaaagagcc cgcagcttca tctcccagct caaacaacac agcggccaca   1320
acagcagcta ttgtcccggg ctcccagctg atgccttcaa aatcaccttc cacaggaacc   1380
acagagataa gcagtcatga gtcctcccac ggcaccccct ctcagacaac agccaagaac   1440
tgggaactca cagcatccgc ctcccaccag ccgccaggtg tgtatccaca gggccacagc   1500
gacaccactg agggcagagg cagcctgctg acctgcggcg acgtcgagga gaaccccggg   1560
cccatggggg caggtgccac cggccgcgcc atggacgggc cgcgcctgct gctgttgctg   1620
cttctggggg tgtcccttgg aggtgccaag gaggcatgcc ccacaggcct gtacacacac   1680
agcggtgagt gctgcaaagc ctgcaacctg ggcgagggtg tggcccagcc ttgtggagcc   1740
aaccagaccg tgtgtgagcc ctgcctggac agcgtgacgt tctccgacgt ggtgagcgcg   1800
accgagccgt gcaagccgtg caccgagtgc gtggggctcc agagcatgtc ggcgccgtgc   1860
gtggaggccg atgacgccgt gtgccgctgc gcctacggct actaccagga tgagacgact   1920
gggcgctgcg aggcgtgccg cgtgtgcgag gcgggctcgg gcctcgtgtt ctcctgccag   1980
gacaagcaga acaccgtgtg cgaggagtgc cccgacggca cgtattccga cgaggccaac   2040
cacgtggacc cgtgcctgcc ctgcaccgtg tgcgaggaca ccgagcgcca gctccgcgag   2100
tgcacacgct gggccgacgc cgagtgcgag gagatccctg gccgttggat tacacggtcc   2160
acacccccag agggctcgga cagcacagcc cccagcaccc aggagcctga ggcacctcca   2220
gaacaagacc tcatagccag cacggtggca ggtgtggtga ccacagtgat gggcagctcc   2280
cagcccgtgg tgacccgagg caccaccgac aacctcatcc ctgtctattg ctccatcctg   2340
gctgctgtgg ttgtgggtct tgtggcctac atagccttca agaggtgaaa aaccaaaaga   2400
acaagaattt cttggtaaga agccgggaac agacaacaga agtcatgaag cccaagtgaa   2460
atcaaaggtg ctaaatggtc gcccaggaga catccgttgt gcttgcctgc gttttggaag   2520
ctctgaagtc acatcacagg acacggggca gtggcaacct tgtctctatg ccagctcagt   2580
cccatcagag agcgagcgct acccacttct aaatagcaat ttcgccgttg aagaggaagg   2640
gcaaaaccac tagaactctc catcttattt tcatgtatat gtgttcatgc gatcgctccg   2700
gtgcccgtca gtgggcagag cgcacatcgc ccacagtccc cgagaagttg gggggagggg   2760
tcggcaattg aacgggtgcc tagagaaggt ggcgcggggt aaactgggaa agtgatgtcg   2820
tgtactggct ccgccttttt cccgagggtg ggggagaacc gtatataagt gcagtagtcg   2880
ccgtgaacgt tctttttcgc aacgggtttg ccgccagaac acagctgaag cttcgagggg   2940
ctcgcatctc tccttcacgc gcccgccgcc ctacctgagg ccgccatcca cgccggttga   3000
gtcgcgttct gccgcctccc gcctgtggtg cctcctgaac tgcgtccgcc gtctaggtaa   3060
gtttaaagct caggtcgaga ccgggccttt gtccggcgct cccttggagc ctacctagac   3120
tcagccggct ctccacgctt tgcctgaccc tgcttgctca actctacgtc tttgtttcgt   3180
tttctgttct gcgccgttac agatccaagc tgtgaccggc gcctacctga gatcaccggc   3240
gccaccatgg cttcttaccc tggacaccag catgcttctg cctttgacca ggctgccaga   3300
tccaggggcc actccaacag gagaactgcc ctaagaccca gaagacagca ggaagccact   3360
gaggtgaggc ctgagcagaa gatgccaacc ctgctgaggg tgtacattga tggacctcat   3420
ggcatgggca agaccaccac cactcaactg ctggtggcac tgggctccag ggatgacatt   3480
gtgtatgtgc ctgagccaat gacctactgg agagtgctag gagcctctga gaccattgcc   3540
aacatctaca ccacccagca caggctggac cagggagaaa tctctgctgg agatgctgct   3600
gtggtgatga cctctgccca gatcacaatg ggaatgccct atgctgtgac tgatgctgtt   3660
ctggctcctc acattggagg agaggctggc tcttctcatg cccctccacc tgccctgacc   3720
ctgatctttg acagacaccc cattgcagcc ctgctgtgct acccagcagc aaggtacctc   3780
atgggctcca tgaccccaca ggctgtgctg gcttttgtgg ccctgatccc tccaaccctc   3840
cctggcacca acattgttct gggagcactg cctgaagaca gacacattga caggctggca   3900
aagaggcaga gacctggaga gagactggac ctggccatgc tggctgcaat cagaagggtg   3960
tatggactgc tggcaaacac tgtgagatac ctccagtgtg gaggctcttg gagagaggac   4020
tggggacagc tctctggaac agcagtgccc cctcaaggag ctgagcccca gtccaatgct   4080
ggtccaagac cccacattgg ggacaccctg ttcaccctgt tcagagcccc tgagctgctg   4140
gctcccaatg gagacctgta caatgtgttt gcctgggctc tggatgttct agccaagagg   4200
ctgaggtcca tgcatgtgtt catcctggac tatgaccagt cccctgctgg atgcagagat   4260
gctctgctgc aactaacctc tggcatggtg cagacccatg tgaccacccc tggcagcatc   4320
cccaccatct gtgacctagc cagaaccttt gccagggaga tgggagaggc caactaaggc   4380
gcgccactcg agcgctagct ggccagacat gataagatac attgatgagt ttggacaaac   4440
cacaactaga atgcagtgaa aaaaatgctt tatttgtgaa atttgtgatg ctattgcttt   4500
atttgtaacc attataagct gcaataaaca agttaacaac aacaattgca ttcattttat   4560
gtttcaggtt cagggggagg tgtgggaggt tttttaaagc aagtaaaacc tctacaaatg   4620
tggtatggaa ggcgcgccca attcgcccta tagtgagtcg tattacgtcg cgctcactgg   4680
ccgtcgtttt acaacgtcgt gactgggaaa accctggcgt tacccaactt aatcgccttg   4740
cagcacatcc ccctttcgcc agctggcgta atagcgaaga ggcccgcacc gaaacgccct   4800
tcccaacagt tgcgcagcct gaatggcgaa tgggagcgcc ctgtagcggc gcattaagcg   4860
cggcgggtgt ggtggttacg cgcagcgtga ccgctacact tgccagcgcc ctagcgcccg   4920
ctcctttcgc tttcttccct tcctttctcg ccacgttcgc cggctttccc cgtcaagctc   4980
taaatcgggg gctcccttta gggttccgat ttagtgcttt acggcacctc gaccccaaaa   5040
aacttgatta gggtgatggt tggcctgtag tgggccatag ccctgataga cggtttttcg   5100
ccctttgacg ttggagtcca cgttctttaa tagtggactc ttgttccaaa ctggaacaac   5160
actcaaccct atctcggtct attcttttga tttataaggg attttgccga tttcggccta   5220
ttggttaaaa aatgagctga tttaacaaaa atttaacgcg aattttaaca aaatattaac   5280
gcttacaatt taggtggcac ttttcgggga aatgtgcgcg gaacccctat ttgtttattt   5340
ttctaaatac attcaaatat gtatccgctc atgagacaat aaccctgata aatgcttcaa   5400
taatattgaa aaaggaagag tatgagtatt caacatttcc gtgtcgccct tattcccttt   5460
tttgcggcat tttgccttcc tgtttttgct cacccagaaa cgctggtgaa agtaaaagat   5520
gctgaagatc agttgggtgc acgagtgggt tacatcgaac tggatctcaa cagcggtaag   5580
atccttgaga gttttcgccc cgaagaacgt tttccaatga tgagcacttt taaagttctg   5640
ctatgtggcg cggtattatc ccgtattgac gccgggcaag agcaactcgg tcgccgcata   5700
cactattctc agaatgactt ggttgagtac tcaccagtca cagaaaagca tcttacggat   5760
ggcatgacag taagagaatt atgcagtgct gccataacca tgagtgataa cactgcggcc   5820
aacttacttc tgacaacgat cggaggaccg aaggagctaa ccgctttttt gcacaacatg   5880
ggggatcatg taactcgcct tgatcgttgg gaaccggagc tgaatgaagc cataccaaac   5940
gacgagcgtg acaccacgat gcctgtagca atggcaacaa cgttgcgcaa actattaact   6000
ggcgaactac ttactctagc ttcccggcaa caattaatag actggatgga ggcggataaa   6060
gttgcaggac cacttctgcg ctcggccctt ccggctggct ggtttattgc tgataaatct   6120
ggagccggtg agcgtggttc tcgcggtatc attgcagcac tggggccaga tggtaagccc   6180
tcccgtatcg tagttatcta cacgacgggg agtcaggcaa ctatggatga acgaaataga   6240
cagatcgctg agataggtgc ctcactgatt aagcattggt aactgtcaga ccaagtttac   6300
tcatatatac tttagattga tttaaaactt catttttaat ttaaaaggat ctaggtgaag   6360
atcctttttg ataatctcat gaccaaaatc ccttaacgtg agttttcgtt ccactgagcg   6420
tcagaccccg tagaaaagat caaaggatct tcttgagatc ctttttttct gcgcgtaatc   6480
tgctgcttgc aaacaaaaaa accaccgcta ccagcggtgg tttgtttgcc ggatcaagag   6540
ctaccaactc tttttccgaa ggtaactggc ttcagcagag cgcagatacc aaatactgtt   6600
cttctagtgt agccgtagtt aggccaccac ttcaagaact ctgtagcacc gcctacatac   6660
ctcgctctgc taatcctgtt accagtggct gctgccagtg gcgataagtc gtgtcttacc   6720
gggttggact caagacgata gttaccggat aaggcgcagc ggtcgggctg aacggggggt   6780
tcgtgcacac agcccagctt ggagcgaacg acctacaccg aactgagata cctacagcgt   6840
gagctatgag aaagcgccac gcttcccgaa gggagaaagg cggacaggta tccggtaagc   6900
ggcagggtcg gaacaggaga gcgcacgagg gagcttccag ggggaaacgc ctggtatctt   6960
tatagtcctg tcgggtttcg ccacctctga cttgagcgtc gatttttgtg atgctcgtca   7020
ggggggcgga gcctatggaa aaacgccagc aacgcggcct ttttacggtt cctggccttt   7080
tgctggcctt ttgctcacat ggtctttcct gcgttatccc ctgattctgt ggataaccgt   7140
attaccgcct ttgagtgagc tgataccgct cgccgcagcc gaacgaccga gcgcagcgag   7200
tcagtgagcg aggaagcgga gagcgcccaa tacgcaaacc gcctctcccc gcgcgttggc   7260
cgattcatta atgcagctgg cacgacaggt ttcccgactg gaaagcgggc agtgagcgca   7320
acgcaattaa tgtgagttag ctcactcatt aggcacccca ggctttacac tttatgcttc   7380
cggctcgtat gttgtgtgga attgtgagcg gataacaatt tcacacagga aacagctatg   7440
accatgatta cgccaagcgc gtcaattaac cctcactaaa gggaacaaaa gctgttaatt   7500
aa                                                                  7502


<210>  65

<211>  7778
<212>  DNA
<213>  artificial sequence

<220>
<223>  Matrice PD1 locus_IL15_2A_sIL15Ra pCLS30513 full sequence

<400>  65
gactccccag acaggccctg gaaccccccc accttctccc cagccctgct cgtggtgacc     60
gaaggggaca acgccacctt cacctgcagc ttctccaaca catcggagag cttcgtgcta    120
aactggtacc gcatgagccc cagcaaccag acggacaagc tggccgcctt ccccgaggac    180
cgcagccagc ccggccagga ctgccgcttc cgtgtcacac aactgcccaa cgggcgtgac    240
ttccacatga gcgtggtcag ggcccggcgc aatgacagcg gcacctacct ctgtggggcc    300
ggttctggcg tgaaacagac tttgaatttt gaccttctca agttggcggg agacgtggag    360
tccaacccag ggcccggtac cgggtccgcc accatggact ggacctggat tctgttcctc    420
gtggctgctg ctacaagagt gcacagcggc attcatgtct tcattttggg ctgtttcagt    480
gcagggcttc ctaaaacaga agccaactgg gtgaatgtaa taagtgattt gaaaaaaatt    540
gaagatctta ttcaatctat gcatattgat gctactttat atacggaaag tgatgttcac    600
cccagttgca aagtaacagc aatgaagtgc tttctcttgg agttacaagt tatttcactt    660
gagtccggag atgcaagtat tcatgataca gtagaaaatc tgatcatcct agcaaacaac    720
agtttgtctt ctaatgggaa tgtaacagaa tctggatgca aagaatgtga ggaactggag    780
gaaaaaaata ttaaagaatt tttgcagagt tttgtacata ttgtccaaat gttcatcaac    840
acttctggaa gcggagctac taacttcagc ctgctgaagc aggctggaga cgtggaggag    900
aaccctggac ctgggaccgg ctctgcaacc atggattgga cgtggatcct gtttctcgtg    960
gcagctgcca caagagttca cagtatcacg tgccctcccc ccatgtccgt ggaacacgca   1020
gacatctggg tcaagagcta cagcttgtac tccagggagc ggtacatttg taactctggt   1080
ttcaagcgta aagccggcac gtccagcctg acggagtgcg tgttgaacaa ggccacgaat   1140
gtcgcccact ggacaacccc cagtctcaaa tgcattagag accctgccct ggttcaccaa   1200
aggccagcgc caccctccac agtaacgacg gcaggggtga ccccacagcc agagagcctc   1260
tccccttctg gaaaagagcc cgcagcttca tctcccagct caaacaacac agcggccaca   1320
acagcagcta ttgtcccggg ctcccagctg atgccttcaa aatcaccttc cacaggaacc   1380
acagagataa gcagtcatga gtcctcccac ggcaccccct ctcagacaac agccaagaac   1440
tgggaactca cagcatccgc ctcccaccag ccgccaggtg tgtatccaca gggccacagc   1500
gacaccactg agggcagagg cagcctgctg acctgcggcg acgtcgagga gaaccccggg   1560
cccatggggg caggtgccac cggccgcgcc atggacgggc cgcgcctgct gctgttgctg   1620
cttctggggg tgtcccttgg aggtgccaag gaggcatgcc ccacaggcct gtacacacac   1680
agcggtgagt gctgcaaagc ctgcaacctg ggcgagggtg tggcccagcc ttgtggagcc   1740
aaccagaccg tgtgtgagcc ctgcctggac agcgtgacgt tctccgacgt ggtgagcgcg   1800
accgagccgt gcaagccgtg caccgagtgc gtggggctcc agagcatgtc ggcgccgtgc   1860
gtggaggccg atgacgccgt gtgccgctgc gcctacggct actaccagga tgagacgact   1920
gggcgctgcg aggcgtgccg cgtgtgcgag gcgggctcgg gcctcgtgtt ctcctgccag   1980
gacaagcaga acaccgtgtg cgaggagtgc cccgacggca cgtattccga cgaggccaac   2040
cacgtggacc cgtgcctgcc ctgcaccgtg tgcgaggaca ccgagcgcca gctccgcgag   2100
tgcacacgct gggccgacgc cgagtgcgag gagatccctg gccgttggat tacacggtcc   2160
acacccccag agggctcgga cagcacagcc cccagcaccc aggagcctga ggcacctcca   2220
gaacaagacc tcatagccag cacggtggca ggtgtggtga ccacagtgat gggcagctcc   2280
cagcccgtgg tgacccgagg caccaccgac aacctcatcc ctgtctattg ctccatcctg   2340
gctgctgtgg ttgtgggtct tgtggcctac atagccttca agaggtgatc tagagggccc   2400
gtttaaaccc gctgatcagc ctcgactgtg ccttctagtt gccagccatc tgttgtttgc   2460
ccctcccccg tgccttcctt gaccctggaa ggtgccactc ccactgtcct ttcctaataa   2520
aatgaggaaa ttgcatcgca ttgtctgagt aggtgtcatt ctattctggg gggtggggtg   2580
gggcaggaca gcaaggggga ggattgggaa gacaatagca ggcatgctgg ggatgcggtg   2640
ggctctatga ctagtggcga attcggcgca gatcaaagag agcctgcggg cagagctcag   2700
ggtgacaggt gcggcctcgg aggccccggg gcaggggtga gctgagccgg tcctggggtg   2760
ggtgtcccct cctgcacagg atcaggagct ccagggtcgt agggcaggga ccccccagct   2820
ccagtccagg gctctgtcct gcacctgggg aatggtgacc ggcatctctg tcctctagct   2880
ctggaagcac cccagcccct ctagtctgcc ctcacccctg accctgaccc tccaccctga   2940
ccccgtccta acccctgacc tttggcgatc gctccggtgc ccgtcagtgg gcagagcgca   3000
catcgcccac agtccccgag aagttggggg gaggggtcgg caattgaacg ggtgcctaga   3060
gaaggtggcg cggggtaaac tgggaaagtg atgtcgtgta ctggctccgc ctttttcccg   3120
agggtggggg agaaccgtat ataagtgcag tagtcgccgt gaacgttctt tttcgcaacg   3180
ggtttgccgc cagaacacag ctgaagcttc gaggggctcg catctctcct tcacgcgccc   3240
gccgccctac ctgaggccgc catccacgcc ggttgagtcg cgttctgccg cctcccgcct   3300
gtggtgcctc ctgaactgcg tccgccgtct aggtaagttt aaagctcagg tcgagaccgg   3360
gcctttgtcc ggcgctccct tggagcctac ctagactcag ccggctctcc acgctttgcc   3420
tgaccctgct tgctcaactc tacgtctttg tttcgttttc tgttctgcgc cgttacagat   3480
ccaagctgtg accggcgcct acctgagatc accggcgcca ccatggcttc ttaccctgga   3540
caccagcatg cttctgcctt tgaccaggct gccagatcca ggggccactc caacaggaga   3600
actgccctaa gacccagaag acagcaggaa gccactgagg tgaggcctga gcagaagatg   3660
ccaaccctgc tgagggtgta cattgatgga cctcatggca tgggcaagac caccaccact   3720
caactgctgg tggcactggg ctccagggat gacattgtgt atgtgcctga gccaatgacc   3780
tactggagag tgctaggagc ctctgagacc attgccaaca tctacaccac ccagcacagg   3840
ctggaccagg gagaaatctc tgctggagat gctgctgtgg tgatgacctc tgcccagatc   3900
acaatgggaa tgccctatgc tgtgactgat gctgttctgg ctcctcacat tggaggagag   3960
gctggctctt ctcatgcccc tccacctgcc ctgaccctga tctttgacag acaccccatt   4020
gcagccctgc tgtgctaccc agcagcaagg tacctcatgg gctccatgac cccacaggct   4080
gtgctggctt ttgtggccct gatccctcca accctccctg gcaccaacat tgttctggga   4140
gcactgcctg aagacagaca cattgacagg ctggcaaaga ggcagagacc tggagagaga   4200
ctggacctgg ccatgctggc tgcaatcaga agggtgtatg gactgctggc aaacactgtg   4260
agatacctcc agtgtggagg ctcttggaga gaggactggg gacagctctc tggaacagca   4320
gtgccccctc aaggagctga gccccagtcc aatgctggtc caagacccca cattggggac   4380
accctgttca ccctgttcag agcccctgag ctgctggctc ccaatggaga cctgtacaat   4440
gtgtttgcct gggctctgga tgttctagcc aagaggctga ggtccatgca tgtgttcatc   4500
ctggactatg accagtcccc tgctggatgc agagatgctc tgctgcaact aacctctggc   4560
atggtgcaga cccatgtgac cacccctggc agcatcccca ccatctgtga cctagccaga   4620
acctttgcca gggagatggg agaggccaac taaggcgcgc cactcgagcg ctagctggcc   4680
agacatgata agatacattg atgagtttgg acaaaccaca actagaatgc agtgaaaaaa   4740
atgctttatt tgtgaaattt gtgatgctat tgctttattt gtaaccatta taagctgcaa   4800
taaacaagtt aacaacaaca attgcattca ttttatgttt caggttcagg gggaggtgtg   4860
ggaggttttt taaagcaagt aaaacctcta caaatgtggt atggaaggcg cgcccaattc   4920
gccctatagt gagtcgtatt acgtcgcgct cactggccgt cgttttacaa cgtcgtgact   4980
gggaaaaccc tggcgttacc caacttaatc gccttgcagc acatccccct ttcgccagct   5040
ggcgtaatag cgaagaggcc cgcaccgaaa cgcccttccc aacagttgcg cagcctgaat   5100
ggcgaatggg agcgccctgt agcggcgcat taagcgcggc gggtgtggtg gttacgcgca   5160
gcgtgaccgc tacacttgcc agcgccctag cgcccgctcc tttcgctttc ttcccttcct   5220
ttctcgccac gttcgccggc tttccccgtc aagctctaaa tcgggggctc cctttagggt   5280
tccgatttag tgctttacgg cacctcgacc ccaaaaaact tgattagggt gatggttggc   5340
ctgtagtggg ccatagccct gatagacggt ttttcgccct ttgacgttgg agtccacgtt   5400
ctttaatagt ggactcttgt tccaaactgg aacaacactc aaccctatct cggtctattc   5460
ttttgattta taagggattt tgccgatttc ggcctattgg ttaaaaaatg agctgattta   5520
acaaaaattt aacgcgaatt ttaacaaaat attaacgctt acaatttagg tggcactttt   5580
cggggaaatg tgcgcggaac ccctatttgt ttatttttct aaatacattc aaatatgtat   5640
ccgctcatga gacaataacc ctgataaatg cttcaataat attgaaaaag gaagagtatg   5700
agtattcaac atttccgtgt cgcccttatt cccttttttg cggcattttg ccttcctgtt   5760
tttgctcacc cagaaacgct ggtgaaagta aaagatgctg aagatcagtt gggtgcacga   5820
gtgggttaca tcgaactgga tctcaacagc ggtaagatcc ttgagagttt tcgccccgaa   5880
gaacgttttc caatgatgag cacttttaaa gttctgctat gtggcgcggt attatcccgt   5940
attgacgccg ggcaagagca actcggtcgc cgcatacact attctcagaa tgacttggtt   6000
gagtactcac cagtcacaga aaagcatctt acggatggca tgacagtaag agaattatgc   6060
agtgctgcca taaccatgag tgataacact gcggccaact tacttctgac aacgatcgga   6120
ggaccgaagg agctaaccgc ttttttgcac aacatggggg atcatgtaac tcgccttgat   6180
cgttgggaac cggagctgaa tgaagccata ccaaacgacg agcgtgacac cacgatgcct   6240
gtagcaatgg caacaacgtt gcgcaaacta ttaactggcg aactacttac tctagcttcc   6300
cggcaacaat taatagactg gatggaggcg gataaagttg caggaccact tctgcgctcg   6360
gcccttccgg ctggctggtt tattgctgat aaatctggag ccggtgagcg tggttctcgc   6420
ggtatcattg cagcactggg gccagatggt aagccctccc gtatcgtagt tatctacacg   6480
acggggagtc aggcaactat ggatgaacga aatagacaga tcgctgagat aggtgcctca   6540
ctgattaagc attggtaact gtcagaccaa gtttactcat atatacttta gattgattta   6600
aaacttcatt tttaatttaa aaggatctag gtgaagatcc tttttgataa tctcatgacc   6660
aaaatccctt aacgtgagtt ttcgttccac tgagcgtcag accccgtaga aaagatcaaa   6720
ggatcttctt gagatccttt ttttctgcgc gtaatctgct gcttgcaaac aaaaaaacca   6780
ccgctaccag cggtggtttg tttgccggat caagagctac caactctttt tccgaaggta   6840
actggcttca gcagagcgca gataccaaat actgttcttc tagtgtagcc gtagttaggc   6900
caccacttca agaactctgt agcaccgcct acatacctcg ctctgctaat cctgttacca   6960
gtggctgctg ccagtggcga taagtcgtgt cttaccgggt tggactcaag acgatagtta   7020
ccggataagg cgcagcggtc gggctgaacg gggggttcgt gcacacagcc cagcttggag   7080
cgaacgacct acaccgaact gagataccta cagcgtgagc tatgagaaag cgccacgctt   7140
cccgaaggga gaaaggcgga caggtatccg gtaagcggca gggtcggaac aggagagcgc   7200
acgagggagc ttccaggggg aaacgcctgg tatctttata gtcctgtcgg gtttcgccac   7260
ctctgacttg agcgtcgatt tttgtgatgc tcgtcagggg ggcggagcct atggaaaaac   7320
gccagcaacg cggccttttt acggttcctg gccttttgct ggccttttgc tcacatggtc   7380
tttcctgcgt tatcccctga ttctgtggat aaccgtatta ccgcctttga gtgagctgat   7440
accgctcgcc gcagccgaac gaccgagcgc agcgagtcag tgagcgagga agcggagagc   7500
gcccaatacg caaaccgcct ctccccgcgc gttggccgat tcattaatgc agctggcacg   7560
acaggtttcc cgactggaaa gcgggcagtg agcgcaacgc aattaatgtg agttagctca   7620
ctcattaggc accccaggct ttacacttta tgcttccggc tcgtatgttg tgtggaattg   7680
tgagcggata acaatttcac acaggaaaca gctatgacca tgattacgcc aagcgcgtca   7740
attaaccctc actaaaggga acaaaagctg ttaattaa                           7778


<210>  66

<211>  8177
<212>  DNA
<213>  artificial sequence

<220>
<223>  Matrice CD25 locus_IL12a_2A_IL12b pCLS30520 full sequence

<400>  66
gtttattatt cctgttccac agctattgtc tgccatataa aaacttaggc caggcacagt     60
ggctcacacc tgtaatccca gcactttgga aggccgaggc aggcagatca caaggtcagg    120
agttcgagac cagcctggcc aacatagcaa aaccccatct ctactaaaaa tacaaaaatt    180
agccaggcat ggtggcgtgt gcactggttt agagtgagga ccacattttt ttggtgccgt    240
gttacacata tgaccgtgac tttgttacac cactacagga ggaagagtag aagaacaatc    300
ggttctggcg tgaaacagac tttgaatttt gaccttctca agttggcggg agacgtggag    360
tccaacccag ggcccatgtg gccccctggg tcagcctccc agccaccgcc ctcacctgcc    420
gcggccacag gtctgcatcc agcggctcgc cctgtgtccc tgcagtgccg gctcagcatg    480
tgtccagcgc gcagcctcct ccttgtggct accctggtcc tcctggacca cctcagtttg    540
gccagaaacc tccccgtggc cactccagac ccaggaatgt tcccatgcct tcaccactcc    600
caaaacctgc tgagggccgt cagcaacatg ctccagaagg ccagacaaac tctagaattt    660
tacccttgca cttctgaaga gattgatcat gaagatatca caaaagataa aaccagcaca    720
gtggaggcct gtttaccatt ggaattaacc aagaatgaga gttgcctaaa ttccagagag    780
acctctttca taactaatgg gagttgcctg gcctccagaa agacctcttt tatgatggcc    840
ctgtgcctta gtagtattta tgaagacttg aagatgtacc aggtggagtt caagaccatg    900
aatgcaaagc ttctgatgga tcctaagagg cagatctttc tagatcaaaa catgctggca    960
gttattgatg agctgatgca ggccctgaat ttcaacagtg agactgtgcc acaaaaatcc   1020
tcccttgaag aaccggattt ttataaaact aaaatcaagc tctgcatact tcttcatgct   1080
ttcagaattc gggcagtgac tattgataga gtgatgagct atctgaatgc ttccggaagc   1140
ggagctacta acttcagcct gctgaagcag gctggagacg tggaggagaa ccctggacct   1200
atgtgtcacc agcagttggt catctcttgg ttttccctgg tttttctggc atctcccctc   1260
gtggccatat gggaactgaa gaaagatgtt tatgtcgtag aattggattg gtatccggat   1320
gcccctggag aaatggtggt cctcacctgt gacacccctg aagaagatgg tatcacctgg   1380
accttggacc agagcagtga ggtcttaggc tctggcaaaa ccctgaccat ccaagtcaaa   1440
gagtttggag atgctggcca gtacacctgt cacaaaggag gcgaggttct aagccattcg   1500
ctcctgctgc ttcacaaaaa ggaagatgga atttggtcca ctgatatttt aaaggaccag   1560
aaagaaccca aaaataagac ctttctaaga tgcgaggcca agaattattc tggacgtttc   1620
acctgctggt ggctgacgac aatcagtact gatttgacat tcagtgtcaa aagcagcaga   1680
ggctcttctg acccccaagg ggtgacgtgc ggagctgcta cactctctgc agagagagtc   1740
agaggggaca acaaggagta tgagtactca gtggagtgcc aggaggacag tgcctgccca   1800
gctgctgagg agagtctgcc cattgaggtc atggtggatg ccgttcacaa gctcaagtat   1860
gaaaactaca ccagcagctt cttcatcagg gacatcatca aacctgaccc acccaagaac   1920
ttgcagctga agccattaaa gaattctcgg caggtggagg tcagctggga gtaccctgac   1980
acctggagta ctccacattc ctacttctcc ctgacattct gcgttcaggt ccagggcaag   2040
agcaagagag aaaagaaaga tagagtcttc acggacaaga cctcagccac ggtcatctgc   2100
cgcaaaaatg ccagcattag cgtgcgggcc caggaccgct actatagctc atcttggagc   2160
gaatgggcat ctgtgccctg cagtgagggc agaggcagcc tgctgacctg cggcgacgtc   2220
gaggagaacc ccgggcccat gggggcaggt gccaccggcc gcgccatgga cgggccgcgc   2280
ctgctgctgt tgctgcttct gggggtgtcc cttggaggtg ccaaggaggc atgccccaca   2340
ggcctgtaca cacacagcgg tgagtgctgc aaagcctgca acctgggcga gggtgtggcc   2400
cagccttgtg gagccaacca gaccgtgtgt gagccctgcc tggacagcgt gacgttctcc   2460
gacgtggtga gcgcgaccga gccgtgcaag ccgtgcaccg agtgcgtggg gctccagagc   2520
atgtcggcgc cgtgcgtgga ggccgatgac gccgtgtgcc gctgcgccta cggctactac   2580
caggatgaga cgactgggcg ctgcgaggcg tgccgcgtgt gcgaggcggg ctcgggcctc   2640
gtgttctcct gccaggacaa gcagaacacc gtgtgcgagg agtgccccga cggcacgtat   2700
tccgacgagg ccaaccacgt ggacccgtgc ctgccctgca ccgtgtgcga ggacaccgag   2760
cgccagctcc gcgagtgcac acgctgggcc gacgccgagt gcgaggagat ccctggccgt   2820
tggattacac ggtccacacc cccagagggc tcggacagca cagcccccag cacccaggag   2880
cctgaggcac ctccagaaca agacctcata gccagcacgg tggcaggtgt ggtgaccaca   2940
gtgatgggca gctcccagcc cgtggtgacc cgaggcacca ccgacaacct catccctgtc   3000
tattgctcca tcctggctgc tgtggttgtg ggtcttgtgg cctacatagc cttcaagagg   3060
tgaaaaacca aaagaacaag aatttcttgg taagaagccg ggaacagaca acagaagtca   3120
tgaagcccaa gtgaaatcaa aggtgctaaa tggtcgccca ggagacatcc gttgtgcttg   3180
cctgcgtttt ggaagctctg aagtcacatc acaggacacg gggcagtggc aaccttgtct   3240
ctatgccagc tcagtcccat cagagagcga gcgctaccca cttctaaata gcaatttcgc   3300
cgttgaagag gaagggcaaa accactagaa ctctccatct tattttcatg tatatgtgtt   3360
catgcgatcg ctccggtgcc cgtcagtggg cagagcgcac atcgcccaca gtccccgaga   3420
agttgggggg aggggtcggc aattgaacgg gtgcctagag aaggtggcgc ggggtaaact   3480
gggaaagtga tgtcgtgtac tggctccgcc tttttcccga gggtggggga gaaccgtata   3540
taagtgcagt agtcgccgtg aacgttcttt ttcgcaacgg gtttgccgcc agaacacagc   3600
tgaagcttcg aggggctcgc atctctcctt cacgcgcccg ccgccctacc tgaggccgcc   3660
atccacgccg gttgagtcgc gttctgccgc ctcccgcctg tggtgcctcc tgaactgcgt   3720
ccgccgtcta ggtaagttta aagctcaggt cgagaccggg cctttgtccg gcgctccctt   3780
ggagcctacc tagactcagc cggctctcca cgctttgcct gaccctgctt gctcaactct   3840
acgtctttgt ttcgttttct gttctgcgcc gttacagatc caagctgtga ccggcgccta   3900
cctgagatca ccggcgccac catggcttct taccctggac accagcatgc ttctgccttt   3960
gaccaggctg ccagatccag gggccactcc aacaggagaa ctgccctaag acccagaaga   4020
cagcaggaag ccactgaggt gaggcctgag cagaagatgc caaccctgct gagggtgtac   4080
attgatggac ctcatggcat gggcaagacc accaccactc aactgctggt ggcactgggc   4140
tccagggatg acattgtgta tgtgcctgag ccaatgacct actggagagt gctaggagcc   4200
tctgagacca ttgccaacat ctacaccacc cagcacaggc tggaccaggg agaaatctct   4260
gctggagatg ctgctgtggt gatgacctct gcccagatca caatgggaat gccctatgct   4320
gtgactgatg ctgttctggc tcctcacatt ggaggagagg ctggctcttc tcatgcccct   4380
ccacctgccc tgaccctgat ctttgacaga caccccattg cagccctgct gtgctaccca   4440
gcagcaaggt acctcatggg ctccatgacc ccacaggctg tgctggcttt tgtggccctg   4500
atccctccaa ccctccctgg caccaacatt gttctgggag cactgcctga agacagacac   4560
attgacaggc tggcaaagag gcagagacct ggagagagac tggacctggc catgctggct   4620
gcaatcagaa gggtgtatgg actgctggca aacactgtga gatacctcca gtgtggaggc   4680
tcttggagag aggactgggg acagctctct ggaacagcag tgccccctca aggagctgag   4740
ccccagtcca atgctggtcc aagaccccac attggggaca ccctgttcac cctgttcaga   4800
gcccctgagc tgctggctcc caatggagac ctgtacaatg tgtttgcctg ggctctggat   4860
gttctagcca agaggctgag gtccatgcat gtgttcatcc tggactatga ccagtcccct   4920
gctggatgca gagatgctct gctgcaacta acctctggca tggtgcagac ccatgtgacc   4980
acccctggca gcatccccac catctgtgac ctagccagaa cctttgccag ggagatggga   5040
gaggccaact aaggcgcgcc actcgagcgc tagctggcca gacatgataa gatacattga   5100
tgagtttgga caaaccacaa ctagaatgca gtgaaaaaaa tgctttattt gtgaaatttg   5160
tgatgctatt gctttatttg taaccattat aagctgcaat aaacaagtta acaacaacaa   5220
ttgcattcat tttatgtttc aggttcaggg ggaggtgtgg gaggtttttt aaagcaagta   5280
aaacctctac aaatgtggta tggaaggcgc gcccaattcg ccctatagtg agtcgtatta   5340
cgtcgcgctc actggccgtc gttttacaac gtcgtgactg ggaaaaccct ggcgttaccc   5400
aacttaatcg ccttgcagca catccccctt tcgccagctg gcgtaatagc gaagaggccc   5460
gcaccgaaac gcccttccca acagttgcgc agcctgaatg gcgaatggga gcgccctgta   5520
gcggcgcatt aagcgcggcg ggtgtggtgg ttacgcgcag cgtgaccgct acacttgcca   5580
gcgccctagc gcccgctcct ttcgctttct tcccttcctt tctcgccacg ttcgccggct   5640
ttccccgtca agctctaaat cgggggctcc ctttagggtt ccgatttagt gctttacggc   5700
acctcgaccc caaaaaactt gattagggtg atggttggcc tgtagtgggc catagccctg   5760
atagacggtt tttcgccctt tgacgttgga gtccacgttc tttaatagtg gactcttgtt   5820
ccaaactgga acaacactca accctatctc ggtctattct tttgatttat aagggatttt   5880
gccgatttcg gcctattggt taaaaaatga gctgatttaa caaaaattta acgcgaattt   5940
taacaaaata ttaacgctta caatttaggt ggcacttttc ggggaaatgt gcgcggaacc   6000
cctatttgtt tatttttcta aatacattca aatatgtatc cgctcatgag acaataaccc   6060
tgataaatgc ttcaataata ttgaaaaagg aagagtatga gtattcaaca tttccgtgtc   6120
gcccttattc ccttttttgc ggcattttgc cttcctgttt ttgctcaccc agaaacgctg   6180
gtgaaagtaa aagatgctga agatcagttg ggtgcacgag tgggttacat cgaactggat   6240
ctcaacagcg gtaagatcct tgagagtttt cgccccgaag aacgttttcc aatgatgagc   6300
acttttaaag ttctgctatg tggcgcggta ttatcccgta ttgacgccgg gcaagagcaa   6360
ctcggtcgcc gcatacacta ttctcagaat gacttggttg agtactcacc agtcacagaa   6420
aagcatctta cggatggcat gacagtaaga gaattatgca gtgctgccat aaccatgagt   6480
gataacactg cggccaactt acttctgaca acgatcggag gaccgaagga gctaaccgct   6540
tttttgcaca acatggggga tcatgtaact cgccttgatc gttgggaacc ggagctgaat   6600
gaagccatac caaacgacga gcgtgacacc acgatgcctg tagcaatggc aacaacgttg   6660
cgcaaactat taactggcga actacttact ctagcttccc ggcaacaatt aatagactgg   6720
atggaggcgg ataaagttgc aggaccactt ctgcgctcgg cccttccggc tggctggttt   6780
attgctgata aatctggagc cggtgagcgt ggttctcgcg gtatcattgc agcactgggg   6840
ccagatggta agccctcccg tatcgtagtt atctacacga cggggagtca ggcaactatg   6900
gatgaacgaa atagacagat cgctgagata ggtgcctcac tgattaagca ttggtaactg   6960
tcagaccaag tttactcata tatactttag attgatttaa aacttcattt ttaatttaaa   7020
aggatctagg tgaagatcct ttttgataat ctcatgacca aaatccctta acgtgagttt   7080
tcgttccact gagcgtcaga ccccgtagaa aagatcaaag gatcttcttg agatcctttt   7140
tttctgcgcg taatctgctg cttgcaaaca aaaaaaccac cgctaccagc ggtggtttgt   7200
ttgccggatc aagagctacc aactcttttt ccgaaggtaa ctggcttcag cagagcgcag   7260
ataccaaata ctgttcttct agtgtagccg tagttaggcc accacttcaa gaactctgta   7320
gcaccgccta catacctcgc tctgctaatc ctgttaccag tggctgctgc cagtggcgat   7380
aagtcgtgtc ttaccgggtt ggactcaaga cgatagttac cggataaggc gcagcggtcg   7440
ggctgaacgg ggggttcgtg cacacagccc agcttggagc gaacgaccta caccgaactg   7500
agatacctac agcgtgagct atgagaaagc gccacgcttc ccgaagggag aaaggcggac   7560
aggtatccgg taagcggcag ggtcggaaca ggagagcgca cgagggagct tccaggggga   7620
aacgcctggt atctttatag tcctgtcggg tttcgccacc tctgacttga gcgtcgattt   7680
ttgtgatgct cgtcaggggg gcggagccta tggaaaaacg ccagcaacgc ggccttttta   7740
cggttcctgg ccttttgctg gccttttgct cacatggtct ttcctgcgtt atcccctgat   7800
tctgtggata accgtattac cgcctttgag tgagctgata ccgctcgccg cagccgaacg   7860
accgagcgca gcgagtcagt gagcgaggaa gcggagagcg cccaatacgc aaaccgcctc   7920
tccccgcgcg ttggccgatt cattaatgca gctggcacga caggtttccc gactggaaag   7980
cgggcagtga gcgcaacgca attaatgtga gttagctcac tcattaggca ccccaggctt   8040
tacactttat gcttccggct cgtatgttgt gtggaattgt gagcggataa caatttcaca   8100
caggaaacag ctatgaccat gattacgcca agcgcgtcaa ttaaccctca ctaaagggaa   8160
caaaagctgt taattaa                                                  8177


<210>  67

<211>  6349
<212>  DNA
<213>  artificial sequence

<220>
<223>  Matrice PD1 locus_IL12a_2A_IL12b pCLS30511 full sequence

<400>  67
tcgcgcgttt cggtgatgac ggtgaaaacc tctgacacat gcagctcccg gagacggtca     60
cagcttgtct gtaagcggat gccgggagca gacaagcccg tcagggcgcg tcagcgggtg    120
ttggcgggtg tcggggctgg cttaactatg cggcatcaga gcagattgta ctgagagtgc    180
accatatgcg gtgtgaaata ccgcacagat gcgtaaggag aaaataccgc atcaggcgcc    240
attcgccatt caggctgcgc aactgttggg aagggcgatc ggtgcgggcc tcttcgctat    300
tacgccagct ggcgaaaggg ggatgtgctg caaggcgatt aagttgggta acgccagggt    360
tttcccagtc acgacgttgt aaaacgacgg ccagtgaatt cgagctcggt acctcgcgaa    420
tgcatctaga tgactcccca gacaggccct ggaacccccc caccttctcc ccagccctgc    480
tcgtggtgac cgaaggggac aacgccacct tcacctgcag cttctccaac acatcggaga    540
gcttcgtgct aaactggtac cgcatgagcc ccagcaacca gacggacaag ctggccgcct    600
tccccgagga ccgcagccag cccggccagg actgccgctt ccgtgtcaca caactgccca    660
acgggcgtga cttccacatg agcgtggtca gggcccggcg caatgacagc ggcacctacc    720
tctgtggggc cggttctggc gtgaaacaga ctttgaattt tgaccttctc aagttggcgg    780
gagacgtgga gtccaaccca gggcccatgt ggccccctgg gtcagcctcc cagccaccgc    840
cctcacctgc cgcggccaca ggtctgcatc cagcggctcg ccctgtgtcc ctgcagtgcc    900
ggctcagcat gtgtccagcg cgcagcctcc tccttgtggc taccctggtc ctcctggacc    960
acctcagttt ggccagaaac ctccccgtgg ccactccaga cccaggaatg ttcccatgcc   1020
ttcaccactc ccaaaacctg ctgagggccg tcagcaacat gctccagaag gccagacaaa   1080
ctctagaatt ttacccttgc acttctgaag agattgatca tgaagatatc acaaaagata   1140
aaaccagcac agtggaggcc tgtttaccat tggaattaac caagaatgag agttgcctaa   1200
attccagaga gacctctttc ataactaatg ggagttgcct ggcctccaga aagacctctt   1260
ttatgatggc cctgtgcctt agtagtattt atgaagactt gaagatgtac caggtggagt   1320
tcaagaccat gaatgcaaag cttctgatgg atcctaagag gcagatcttt ctagatcaaa   1380
acatgctggc agttattgat gagctgatgc aggccctgaa tttcaacagt gagactgtgc   1440
cacaaaaatc ctcccttgaa gaaccggatt tttataaaac taaaatcaag ctctgcatac   1500
ttcttcatgc tttcagaatt cgggcagtga ctattgatag agtgatgagc tatctgaatg   1560
cttccggaag cggagctact aacttcagcc tgctgaagca ggctggagac gtggaggaga   1620
accctggacc tatgtgtcac cagcagttgg tcatctcttg gttttccctg gtttttctgg   1680
catctcccct cgtggccata tgggaactga agaaagatgt ttatgtcgta gaattggatt   1740
ggtatccgga tgcccctgga gaaatggtgg tcctcacctg tgacacccct gaagaagatg   1800
gtatcacctg gaccttggac cagagcagtg aggtcttagg ctctggcaaa accctgacca   1860
tccaagtcaa agagtttgga gatgctggcc agtacacctg tcacaaagga ggcgaggttc   1920
taagccattc gctcctgctg cttcacaaaa aggaagatgg aatttggtcc actgatattt   1980
taaaggacca gaaagaaccc aaaaataaga cctttctaag atgcgaggcc aagaattatt   2040
ctggacgttt cacctgctgg tggctgacga caatcagtac tgatttgaca ttcagtgtca   2100
aaagcagcag aggctcttct gacccccaag gggtgacgtg cggagctgct acactctctg   2160
cagagagagt cagaggggac aacaaggagt atgagtactc agtggagtgc caggaggaca   2220
gtgcctgccc agctgctgag gagagtctgc ccattgaggt catggtggat gccgttcaca   2280
agctcaagta tgaaaactac accagcagct tcttcatcag ggacatcatc aaacctgacc   2340
cacccaagaa cttgcagctg aagccattaa agaattctcg gcaggtggag gtcagctggg   2400
agtaccctga cacctggagt actccacatt cctacttctc cctgacattc tgcgttcagg   2460
tccagggcaa gagcaagaga gaaaagaaag atagagtctt cacggacaag acctcagcca   2520
cggtcatctg ccgcaaaaat gccagcatta gcgtgcgggc ccaggaccgc tactatagct   2580
catcttggag cgaatgggca tctgtgccct gcagtgaggg cagaggcagc ctgctgacct   2640
gcggcgacgt cgaggagaac cccgggccca tgggggcagg tgccaccggc cgcgccatgg   2700
acgggccgcg cctgctgctg ttgctgcttc tgggggtgtc ccttggaggt gccaaggagg   2760
catgccccac aggcctgtac acacacagcg gtgagtgctg caaagcctgc aacctgggcg   2820
agggtgtggc ccagccttgt ggagccaacc agaccgtgtg tgagccctgc ctggacagcg   2880
tgacgttctc cgacgtggtg agcgcgaccg agccgtgcaa gccgtgcacc gagtgcgtgg   2940
ggctccagag catgtcggcg ccgtgcgtgg aggccgatga cgccgtgtgc cgctgcgcct   3000
acggctacta ccaggatgag acgactgggc gctgcgaggc gtgccgcgtg tgcgaggcgg   3060
gctcgggcct cgtgttctcc tgccaggaca agcagaacac cgtgtgcgag gagtgccccg   3120
acggcacgta ttccgacgag gccaaccacg tggacccgtg cctgccctgc accgtgtgcg   3180
aggacaccga gcgccagctc cgcgagtgca cacgctgggc cgacgccgag tgcgaggaga   3240
tccctggccg ttggattaca cggtccacac ccccagaggg ctcggacagc acagccccca   3300
gcacccagga gcctgaggca cctccagaac aagacctcat agccagcacg gtggcaggtg   3360
tggtgaccac agtgatgggc agctcccagc ccgtggtgac ccgaggcacc accgacaacc   3420
tcatccctgt ctattgctcc atcctggctg ctgtggttgt gggtcttgtg gcctacatag   3480
ccttcaagag gtgatctaga gggcccgttt aaacccgctg atcagcctcg actgtgcctt   3540
ctagttgcca gccatctgtt gtttgcccct cccccgtgcc ttccttgacc ctggaaggtg   3600
ccactcccac tgtcctttcc taataaaatg aggaaattgc atcgcattgt ctgagtaggt   3660
gtcattctat tctggggggt ggggtggggc aggacagcaa gggggaggat tgggaagaca   3720
atagcaggca tgctggggat gcggtgggct ctatgactag tggcgaattc ggcgcagatc   3780
aaagagagcc tgcgggcaga gctcagggtg acaggtgcgg cctcggaggc cccggggcag   3840
gggtgagctg agccggtcct ggggtgggtg tcccctcctg cacaggatca ggagctccag   3900
ggtcgtaggg cagggacccc ccagctccag tccagggctc tgtcctgcac ctggggaatg   3960
gtgaccggca tctctgtcct ctagctctgg aagcacccca gcccctctag tctgccctca   4020
cccctgaccc tgaccctcca ccctgacccc gtcctaaccc ctgacctttg atcggatccc   4080
gggcccgtcg actgcagagg cctgcatgca agcttggcgt aatcatggtc atagctgttt   4140
cctgtgtgaa attgttatcc gctcacaatt ccacacaaca tacgagccgg aagcataaag   4200
tgtaaagcct ggggtgccta atgagtgagc taactcacat taattgcgtt gcgctcactg   4260
cccgctttcc agtcgggaaa cctgtcgtgc cagctgcatt aatgaatcgg ccaacgcgcg   4320
gggagaggcg gtttgcgtat tgggcgctct tccgcttcct cgctcactga ctcgctgcgc   4380
tcggtcgttc ggctgcggcg agcggtatca gctcactcaa aggcggtaat acggttatcc   4440
acagaatcag gggataacgc aggaaagaac atgtgagcaa aaggccagca aaaggccagg   4500
aaccgtaaaa aggccgcgtt gctggcgttt ttccataggc tccgcccccc tgacgagcat   4560
cacaaaaatc gacgctcaag tcagaggtgg cgaaacccga caggactata aagataccag   4620
gcgtttcccc ctggaagctc cctcgtgcgc tctcctgttc cgaccctgcc gcttaccgga   4680
tacctgtccg cctttctccc ttcgggaagc gtggcgcttt ctcatagctc acgctgtagg   4740
tatctcagtt cggtgtaggt cgttcgctcc aagctgggct gtgtgcacga accccccgtt   4800
cagcccgacc gctgcgcctt atccggtaac tatcgtcttg agtccaaccc ggtaagacac   4860
gacttatcgc cactggcagc agccactggt aacaggatta gcagagcgag gtatgtaggc   4920
ggtgctacag agttcttgaa gtggtggcct aactacggct acactagaag aacagtattt   4980
ggtatctgcg ctctgctgaa gccagttacc ttcggaaaaa gagttggtag ctcttgatcc   5040
ggcaaacaaa ccaccgctgg tagcggtggt ttttttgttt gcaagcagca gattacgcgc   5100
agaaaaaaag gatctcaaga agatcctttg atcttttcta cggggtctga cgctcagtgg   5160
aacgaaaact cacgttaagg gattttggtc atgagattat caaaaaggat cttcacctag   5220
atccttttaa attaaaaatg aagttttaaa tcaatctaaa gtatatatga gtaaacttgg   5280
tctgacagtt accaatgctt aatcagtgag gcacctatct cagcgatctg tctatttcgt   5340
tcatccatag ttgcctgact ccccgtcgtg tagataacta cgatacggga gggcttacca   5400
tctggcccca gtgctgcaat gataccgcga gacccacgct caccggctcc agatttatca   5460
gcaataaacc agccagccgg aagggccgag cgcagaagtg gtcctgcaac tttatccgcc   5520
tccatccagt ctattaattg ttgccgggaa gctagagtaa gtagttcgcc agttaatagt   5580
ttgcgcaacg ttgttgccat tgctacaggc atcgtggtgt cacgctcgtc gtttggtatg   5640
gcttcattca gctccggttc ccaacgatca aggcgagtta catgatcccc catgttgtgc   5700
aaaaaagcgg ttagctcctt cggtcctccg atcgttgtca gaagtaagtt ggccgcagtg   5760
ttatcactca tggttatggc agcactgcat aattctctta ctgtcatgcc atccgtaaga   5820
tgcttttctg tgactggtga gtactcaacc aagtcattct gagaatagtg tatgcggcga   5880
ccgagttgct cttgcccggc gtcaatacgg gataataccg cgccacatag cagaacttta   5940
aaagtgctca tcattggaaa acgttcttcg gggcgaaaac tctcaaggat cttaccgctg   6000
ttgagatcca gttcgatgta acccactcgt gcacccaact gatcttcagc atcttttact   6060
ttcaccagcg tttctgggtg agcaaaaaca ggaaggcaaa atgccgcaaa aaagggaata   6120
agggcgacac ggaaatgttg aatactcata ctcttccttt ttcaatatta ttgaagcatt   6180
tatcagggtt attgtctcat gagcggatac atatttgaat gtatttagaa aaataaacaa   6240
ataggggttc cgcgcacatt tccccgaaaa gtgccacctg acgtctaaga aaccattatt   6300
atcatgacat taacctataa aaataggcgt atcacgaggc cctttcgtc               6349



