                         SEQUENCE LISTING

<110>  SANOFI
 
<120>  Anti-CHIKV antibodies and uses thereof

<130>  FR2016/026

<160>  63    

<170>  PatentIn version 3.5

<210>  1
<211>  126
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH mAb1

<400>  1

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Ser Phe Thr Ser Tyr 
            20                  25                  30          


Gly Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Ser Thr Tyr Lys Gly Tyr Thr Gln Tyr Ala Gln Asn Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Thr Asp Thr Pro Ala Thr Thr Val Tyr 
65                  70                  75                  80  


Met Glu Leu Arg Ser Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Val Leu Ser Glu Thr Gly Tyr Phe Tyr Tyr Tyr Tyr Tyr Gly 
            100                 105                 110         


Met Asp Val Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125     


<210>  2
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL mAb1

<400>  2

Gln Ala Val Val Thr Gln Pro Pro Ser Val Ser Gly Ala Pro Gly Gln 
1               5                   10                  15      


Arg Val Thr Ile Ser Cys Thr Gly Ser Ser Ser Asn Ile Gly Ala Asp 
            20                  25                  30          


Tyr Asn Val His Trp Tyr Gln Leu Leu Pro Gly Thr Ala Pro Lys Leu 
        35                  40                  45              


Leu Ile Tyr Gly Asn Thr Asn Arg Pro Ser Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Thr Gly Leu 
65                  70                  75                  80  


Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Gln Ser Tyr Asp Ser Ser 
                85                  90                  95      


Leu Ser Ala Ser Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 110     


<210>  3
<211>  123
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH mAb2

<400>  3

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Val Ser Gly Tyr Ile Leu Ser Lys Leu 
            20                  25                  30          


Ser Val His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Gly Ser Glu Arg Glu Asp Gly Glu Thr Val Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Ile Ser Leu Thr Glu Asp Thr Ser Ile Glu Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Ser Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Thr Gly Gly Phe Trp Ser Met Ile Gly Gly Asn Gly Val Asp Tyr 
            100                 105                 110         


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120             


<210>  4
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL mAb2

<400>  4

Gln Ala Val Val Thr Gln Ser Pro Ser Ser Leu Pro Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Ile Arg Asn Asn 
            20                  25                  30          


Leu Gly Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Glu Arg Leu Ile 
        35                  40                  45              


Tyr Gly Thr Ser Asn Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Leu Gln His Asn Ser Tyr Pro Pro 
                85                  90                  95      


Thr Phe Gly Arg Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  5
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH1 mAb1

<400>  5

Gly Tyr Ser Phe Thr Ser Tyr Gly 
1               5               


<210>  6
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH2 mAb1

<400>  6

Ile Ser Thr Tyr Lys Gly Tyr Thr 
1               5               


<210>  7
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH3 mAb1

<400>  7

Ala Arg Val Leu Ser Glu Thr Gly Tyr Phe Tyr Tyr Tyr Tyr Tyr Gly 
1               5                   10                  15      


Met Asp Val 
            


<210>  8
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRL1 mAb1

<400>  8

Ser Ser Asn Ile Gly Ala Asp Tyr Asn 
1               5                   


<210>  9
<211>  863
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  His-tagged CHIKVE2 LR2006

<400>  9

Ser Leu Ala Ile Pro Val Met Cys Leu Leu Ala Asn Thr Thr Phe Pro 
1               5                   10                  15      


Cys Ser Gln Pro Pro Cys Thr Pro Cys Cys Tyr Glu Lys Glu Pro Glu 
            20                  25                  30          


Glu Thr Leu Arg Met Leu Glu Asp Asn Val Met Arg Pro Gly Tyr Tyr 
        35                  40                  45              


Gln Leu Leu Gln Ala Ser Leu Thr Cys Ser Pro His Arg Gln Arg Arg 
    50                  55                  60                  


Ser Thr Lys Asp Asn Phe Asn Val Tyr Lys Ala Thr Arg Pro Tyr Leu 
65                  70                  75                  80  


Ala His Cys Pro Asp Cys Gly Glu Gly His Ser Cys His Ser Pro Val 
                85                  90                  95      


Ala Leu Glu Arg Ile Arg Asn Glu Ala Thr Asp Gly Thr Leu Lys Ile 
            100                 105                 110         


Gln Val Ser Leu Gln Ile Gly Ile Lys Thr Asp Asp Ser His Asp Trp 
        115                 120                 125             


Thr Lys Leu Arg Tyr Met Asp Asn His Met Pro Ala Asp Ala Glu Arg 
    130                 135                 140                 


Ala Gly Leu Phe Val Arg Thr Ser Ala Pro Cys Thr Ile Thr Gly Thr 
145                 150                 155                 160 


Met Gly His Phe Ile Leu Ala Arg Cys Pro Lys Gly Glu Thr Leu Thr 
                165                 170                 175     


Val Gly Phe Thr Asp Ser Arg Lys Ile Ser His Ser Cys Thr His Pro 
            180                 185                 190         


Phe His His Asp Pro Pro Val Ile Gly Arg Glu Lys Phe His Ser Arg 
        195                 200                 205             


Pro Gln His Gly Lys Glu Leu Pro Cys Ser Thr Tyr Val Gln Ser Thr 
    210                 215                 220                 


Ala Ala Thr Thr Glu Glu Ile Glu Val His Met Pro Pro Asp Thr Pro 
225                 230                 235                 240 


Asp Arg Thr Leu Met Ser Gln Gln Ser Gly Asn Val Lys Ile Thr Val 
                245                 250                 255     


Asn Gly Gln Thr Val Arg Tyr Lys Cys Asn Cys Gly Gly Ser Asn Glu 
            260                 265                 270         


Gly Leu Thr Thr Thr Asp Lys Val Ile Asn Asn Cys Lys Val Asp Gln 
        275                 280                 285             


Cys His Ala Ala Val Thr Asn His Lys Lys Trp Gln Tyr Asn Ser Pro 
    290                 295                 300                 


Leu Val Pro Arg Asn Ala Glu Leu Gly Asp Arg Lys Gly Lys Ile His 
305                 310                 315                 320 


Ile Pro Phe Pro Leu Ala Asn Val Thr Cys Arg Val Pro Lys Ala Arg 
                325                 330                 335     


Asn Pro Thr Val Thr Tyr Gly Lys Asn Gln Val Ile Met Leu Leu Tyr 
            340                 345                 350         


Pro Asp His Pro Thr Leu Leu Ser Tyr Arg Asn Met Gly Glu Glu Pro 
        355                 360                 365             


Asn Tyr Gln Glu Glu Trp Val Met His Lys Lys Glu Val Val Leu Thr 
    370                 375                 380                 


Val Pro Thr Glu Gly Leu Glu Val Thr Trp Gly Asn Asn Glu Pro Tyr 
385                 390                 395                 400 


Lys Tyr Trp Pro Gln Leu Ser Thr Asn Gly Thr Ala His Gly His Pro 
                405                 410                 415     


His Glu Ile Ile Leu Tyr Tyr Tyr Glu Gly Gly Gly Gly Ser Gly Gly 
            420                 425                 430         


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Tyr Glu His Val 
        435                 440                 445             


Thr Val Ile Pro Asn Thr Val Gly Val Pro Tyr Lys Thr Leu Val Asn 
    450                 455                 460                 


Arg Pro Gly Tyr Ser Pro Met Val Leu Glu Met Glu Leu Leu Ser Val 
465                 470                 475                 480 


Thr Leu Glu Pro Thr Leu Ser Leu Asp Tyr Ile Thr Cys Glu Tyr Lys 
                485                 490                 495     


Thr Val Ile Pro Ser Pro Tyr Val Lys Cys Cys Gly Thr Ala Glu Cys 
            500                 505                 510         


Lys Asp Lys Asn Leu Pro Asp Tyr Ser Cys Lys Val Phe Thr Gly Val 
        515                 520                 525             


Tyr Pro Phe Met Trp Gly Gly Ala Tyr Cys Phe Cys Asp Ala Glu Asn 
    530                 535                 540                 


Thr Gln Leu Ser Glu Ala His Val Glu Lys Ser Glu Ser Cys Lys Thr 
545                 550                 555                 560 


Glu Phe Ala Ser Ala Tyr Arg Ala His Thr Ala Ser Ala Ser Ala Lys 
                565                 570                 575     


Leu Arg Val Leu Tyr Gln Gly Asn Asn Ile Thr Val Thr Ala Tyr Ala 
            580                 585                 590         


Asn Gly Asp His Ala Val Thr Val Lys Asp Ala Lys Phe Ile Val Gly 
        595                 600                 605             


Pro Met Ser Ser Ala Trp Thr Pro Phe Asp Asn Lys Ile Val Val Tyr 
    610                 615                 620                 


Lys Gly Asp Val Tyr Asn Met Asp Tyr Pro Pro Phe Gly Ala Gly Arg 
625                 630                 635                 640 


Pro Gly Gln Phe Gly Asp Ile Gln Ser Arg Thr Pro Glu Ser Lys Asp 
                645                 650                 655     


Val Tyr Ala Asn Thr Gln Leu Val Leu Gln Arg Pro Ala Val Gly Thr 
            660                 665                 670         


Val His Val Pro Tyr Ser Gln Ala Pro Ser Gly Phe Lys Tyr Trp Leu 
        675                 680                 685             


Lys Glu Arg Gly Ala Ser Leu Gln His Thr Ala Pro Phe Gly Cys Gln 
    690                 695                 700                 


Ile Ala Thr Asn Pro Val Arg Ala Val Asn Cys Ala Val Gly Asn Met 
705                 710                 715                 720 


Pro Ile Ser Ile Asp Ile Pro Glu Ala Ala Phe Thr Arg Val Val Asp 
                725                 730                 735     


Ala Pro Ser Leu Thr Asp Met Ser Cys Glu Val Pro Ala Cys Thr His 
            740                 745                 750         


Ser Ser Asp Phe Gly Gly Val Ala Ile Ile Lys Tyr Ala Ala Ser Lys 
        755                 760                 765             


Lys Gly Lys Cys Ala Val His Ser Met Thr Asn Ala Val Thr Ile Arg 
    770                 775                 780                 


Glu Ala Glu Ile Glu Val Glu Gly Asn Ser Gln Leu Gln Ile Ser Phe 
785                 790                 795                 800 


Ser Thr Ala Leu Ala Ser Ala Glu Phe Arg Val Gln Val Cys Ser Thr 
                805                 810                 815     


Gln Val His Cys Ala Ala Glu Cys His Pro Pro Lys Asp His Ile Val 
            820                 825                 830         


Asn Tyr Pro Ala Ser His Thr Thr Leu Gly Val Gln Asp Ile Ser Ala 
        835                 840                 845             


Thr Ala Met Ser Trp Val Gln His His His His His His His His 
    850                 855                 860             


<210>  10
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRL3 mAb1

<400>  10

Gln Ser Tyr Asp Ser Ser Leu Ser Ala Ser Val 
1               5                   10      


<210>  11
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH1 mAb2

<400>  11

Gly Tyr Ile Leu Ser Lys Leu Ser 
1               5               


<210>  12
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH2 mAb2

<400>  12

Ser Glu Arg Glu Asp Gly Glu Thr 
1               5               


<210>  13
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH3 mAb2

<400>  13

Ala Thr Gly Gly Phe Trp Ser Met Ile Gly Gly Asn Gly Val Asp Tyr 
1               5                   10                  15      


<210>  14
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRL1 mAb2

<400>  14

Gln Asp Ile Arg Asn Asn 
1               5       


<210>  15
<211>  863
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  His-tagged CHIKVE2 SL15649

<400>  15

Ser Leu Ala Ile Pro Val Met Cys Leu Leu Ala Asn Thr Thr Phe Pro 
1               5                   10                  15      


Cys Ser Gln Pro Pro Cys Thr Pro Cys Cys Tyr Glu Lys Glu Pro Glu 
            20                  25                  30          


Glu Thr Leu Arg Met Leu Glu Asp Asn Val Met Arg Pro Gly Tyr Tyr 
        35                  40                  45              


Gln Leu Leu Gln Ala Ser Leu Thr Cys Ser Pro His Arg Gln Arg Arg 
    50                  55                  60                  


Ser Thr Lys Asp Asn Phe Asn Val Tyr Lys Ala Thr Arg Pro Tyr Leu 
65                  70                  75                  80  


Ala His Cys Pro Asp Cys Gly Glu Gly His Ser Cys His Ser Pro Val 
                85                  90                  95      


Ala Leu Glu Arg Ile Arg Asn Glu Ala Thr Asp Gly Thr Leu Lys Ile 
            100                 105                 110         


Gln Val Ser Leu Gln Ile Gly Ile Lys Thr Asp Asp Ser His Asp Trp 
        115                 120                 125             


Thr Lys Leu Arg Tyr Met Asp Asn His Met Pro Ala Asp Ala Glu Arg 
    130                 135                 140                 


Ala Gly Leu Phe Val Arg Thr Ser Ala Pro Cys Thr Ile Thr Gly Thr 
145                 150                 155                 160 


Met Gly His Phe Ile Leu Ala Arg Cys Pro Lys Gly Glu Thr Leu Thr 
                165                 170                 175     


Val Gly Phe Thr Asp Ser Arg Lys Ile Ser His Ser Cys Thr His Pro 
            180                 185                 190         


Phe His His Asp Pro Pro Val Ile Gly Arg Glu Lys Phe His Ser Arg 
        195                 200                 205             


Pro Gln His Gly Lys Glu Leu Pro Cys Ser Thr Tyr Val Gln Ser Thr 
    210                 215                 220                 


Ala Ala Thr Thr Glu Glu Ile Glu Val His Met Pro Pro Asp Thr Pro 
225                 230                 235                 240 


Asp Arg Thr Leu Met Ser Gln Gln Ser Gly Asn Val Lys Ile Thr Val 
                245                 250                 255     


Asn Gly Gln Thr Val Arg Tyr Lys Cys Asn Cys Gly Gly Ser Asn Glu 
            260                 265                 270         


Gly Leu Thr Thr Thr Asp Lys Val Ile Asn Asn Cys Lys Val Asp Gln 
        275                 280                 285             


Cys His Ala Ala Val Thr Asn His Lys Lys Trp Gln Tyr Asn Ser Pro 
    290                 295                 300                 


Leu Val Pro Arg Asn Ala Glu Leu Gly Asp Arg Lys Gly Lys Ile His 
305                 310                 315                 320 


Ile Pro Phe Pro Leu Ala Asn Val Thr Cys Arg Val Pro Lys Ala Arg 
                325                 330                 335     


Asn Pro Thr Val Thr Tyr Gly Lys Asn Gln Val Ile Met Leu Leu Tyr 
            340                 345                 350         


Pro Asp His Pro Thr Leu Leu Ser Tyr Arg Asn Met Gly Glu Glu Pro 
        355                 360                 365             


Asn Tyr Gln Glu Glu Trp Val Met His Lys Lys Glu Val Val Leu Thr 
    370                 375                 380                 


Val Pro Thr Glu Gly Leu Glu Val Thr Trp Gly Asn Asn Glu Pro Tyr 
385                 390                 395                 400 


Lys Tyr Trp Pro Gln Leu Ser Thr Asn Gly Thr Ala His Gly His Pro 
                405                 410                 415     


His Glu Ile Ile Leu Tyr Tyr Tyr Glu Gly Gly Gly Gly Ser Gly Gly 
            420                 425                 430         


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Tyr Glu His Val 
        435                 440                 445             


Thr Val Ile Pro Asn Thr Val Gly Val Pro Tyr Lys Thr Leu Val Asn 
    450                 455                 460                 


Arg Pro Gly Tyr Ser Pro Met Val Leu Glu Met Glu Leu Leu Ser Val 
465                 470                 475                 480 


Thr Leu Glu Pro Thr Leu Ser Leu Asp Tyr Ile Thr Cys Glu Tyr Lys 
                485                 490                 495     


Thr Val Ile Pro Ser Pro Tyr Val Lys Cys Cys Gly Thr Ala Glu Cys 
            500                 505                 510         


Lys Asp Lys Asn Leu Pro Asp Tyr Ser Cys Lys Val Phe Thr Gly Val 
        515                 520                 525             


Tyr Pro Phe Met Trp Gly Gly Ala Tyr Cys Phe Cys Asp Ala Glu Asn 
    530                 535                 540                 


Thr Gln Leu Ser Glu Ala His Val Glu Lys Ser Glu Ser Cys Lys Thr 
545                 550                 555                 560 


Glu Phe Ala Ser Ala Tyr Arg Ala His Thr Ala Ser Ala Ser Ala Lys 
                565                 570                 575     


Leu Arg Val Leu Tyr Gln Gly Asn Asn Ile Thr Val Thr Ala Tyr Ala 
            580                 585                 590         


Asn Gly Asp His Ala Val Thr Val Lys Asp Ala Lys Phe Ile Val Gly 
        595                 600                 605             


Pro Met Ser Ser Ala Trp Thr Pro Phe Asp Asn Lys Ile Val Val Tyr 
    610                 615                 620                 


Lys Gly Asp Val Tyr Asn Met Asp Tyr Pro Pro Phe Gly Ala Gly Arg 
625                 630                 635                 640 


Pro Gly Gln Phe Gly Asp Ile Gln Ser Arg Thr Pro Glu Ser Lys Asp 
                645                 650                 655     


Val Tyr Ala Asn Thr Gln Leu Val Leu Gln Arg Pro Ala Ala Gly Thr 
            660                 665                 670         


Val His Val Pro Tyr Ser Gln Ala Pro Ser Gly Phe Lys Tyr Trp Leu 
        675                 680                 685             


Lys Glu Arg Gly Ala Ser Leu Gln His Thr Ala Pro Phe Gly Cys Gln 
    690                 695                 700                 


Ile Ala Thr Asn Pro Val Arg Ala Val Asn Cys Ala Val Gly Asn Met 
705                 710                 715                 720 


Pro Ile Ser Ile Asp Ile Pro Glu Ala Ala Phe Thr Arg Val Val Asp 
                725                 730                 735     


Ala Pro Ser Leu Thr Asp Met Ser Cys Glu Val Leu Ala Cys Thr His 
            740                 745                 750         


Ser Ser Asp Phe Gly Gly Val Ala Ile Ile Lys Tyr Ala Ala Ser Lys 
        755                 760                 765             


Lys Gly Lys Cys Ala Val His Ser Met Thr Asn Ala Val Thr Ile Arg 
    770                 775                 780                 


Glu Ala Glu Ile Glu Val Glu Gly Asn Ser Gln Leu Gln Ile Ser Phe 
785                 790                 795                 800 


Ser Thr Ala Leu Ala Ser Ala Glu Phe Arg Val Gln Val Cys Ser Thr 
                805                 810                 815     


Gln Val His Cys Ala Ala Glu Cys His Pro Pro Lys Asp His Ile Val 
            820                 825                 830         


Asn Tyr Pro Ala Ser His Thr Thr Leu Gly Val Gln Asp Ile Ser Ala 
        835                 840                 845             


Thr Ala Met Ser Trp Val Gln His His His His His His His His 
    850                 855                 860             


<210>  16
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRL3 mAb2

<400>  16

Leu Gln His Asn Ser Tyr Pro Pro Thr 
1               5                   


<210>  17
<211>  221
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IgG1 Fc region without substitution

<400>  17

Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe 
1               5                   10                  15      


Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro 
            20                  25                  30          


Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val 
        35                  40                  45              


Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr 
    50                  55                  60                  


Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val 
65                  70                  75                  80  


Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys 
                85                  90                  95      


Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser 
            100                 105                 110         


Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro 
        115                 120                 125             


Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val 
    130                 135                 140                 


Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly 
145                 150                 155                 160 


Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp 
                165                 170                 175     


Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp 
            180                 185                 190         


Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His 
        195                 200                 205             


Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
    210                 215                 220     


<210>  18
<211>  663
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  IgG1 Fc region without substitution nucleic acid sequence


<220>
<221>  exon
<222>  (1)..(663)

<400>  18
tgt ccc cct tgt cct gcc cct gaa ctg ctg ggc gga cct tcc gtg ttc         48
Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe           
1               5                   10                  15                

ctg ttc ccc cca aag ccc aag gac acc ctg atg atc agc cgg acc ccc         96
Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro           
            20                  25                  30                    

gaa gtg acc tgc gtg gtg gtg gat gtg tcc cac gag gac cct gaa gtg        144
Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val           
        35                  40                  45                        

aag ttc aat tgg tac gtg gac ggc gtg gaa gtg cac aac gcc aag acc        192
Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr           
    50                  55                  60                            

aag ccc aga gag gaa cag tac aac tcc acc tac cgg gtg gtg tcc gtg        240
Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val           
65                  70                  75                  80            

ctg aca gtg ctg cac cag gac tgg ctg aac ggc aaa gag tac aag tgc        288
Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys           
                85                  90                  95                

aag gtg tcc aac aaa gcc ctg cct gcc ccc atc gag aaa acc atc agc        336
Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser           
            100                 105                 110                   

aag gcc aag ggc cag ccc cgc gaa ccc cag gtg tac aca ctg cct ccc        384
Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro           
        115                 120                 125                       

agc agg gac gag ctg acc aag aac cag gtg tcc ctg acc tgt ctc gtg        432
Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val           
    130                 135                 140                           

aaa ggc ttc tac ccc tcc gat atc gcc gtg gaa tgg gag agc aac ggc        480
Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly           
145                 150                 155                 160           

cag ccc gag aac aac tac aag acc acc ccc cct gtg ctg gac agc gac        528
Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp           
                165                 170                 175               

ggc tca ttc ttc ctg tac agc aag ctg acc gtg gac aag tcc cgg tgg        576
Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp           
            180                 185                 190                   

cag cag ggc aac gtg ttc agc tgc agc gtg atg cac gag gcc ctg cac        624
Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His           
        195                 200                 205                       

aac cac tac aca cag aag tcc ctg agc ctg agc ccc ggc                    663
Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly                       
    210                 215                 220                           


<210>  19
<211>  455
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HC mAb1

<400>  19

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Ser Phe Thr Ser Tyr 
            20                  25                  30          


Gly Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Ser Thr Tyr Lys Gly Tyr Thr Gln Tyr Ala Gln Asn Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Thr Asp Thr Pro Ala Thr Thr Val Tyr 
65                  70                  75                  80  


Met Glu Leu Arg Ser Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Val Leu Ser Glu Thr Gly Tyr Phe Tyr Tyr Tyr Tyr Tyr Gly 
            100                 105                 110         


Met Asp Val Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser 
        115                 120                 125             


Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr 
    130                 135                 140                 


Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro 
145                 150                 155                 160 


Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val 
                165                 170                 175     


His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser 
            180                 185                 190         


Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile 
        195                 200                 205             


Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val 
    210                 215                 220                 


Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 
225                 230                 235                 240 


Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 
                245                 250                 255     


Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 
            260                 265                 270         


Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 
        275                 280                 285             


Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 
    290                 295                 300                 


Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 
305                 310                 315                 320 


Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala 
                325                 330                 335     


Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 
            340                 345                 350         


Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr 
        355                 360                 365             


Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser 
    370                 375                 380                 


Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 
385                 390                 395                 400 


Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 
                405                 410                 415     


Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 
            420                 425                 430         


Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 
        435                 440                 445             


Ser Leu Ser Leu Ser Pro Gly 
    450                 455 


<210>  20
<211>  217
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LC mAb1

<400>  20

Gln Ala Val Val Thr Gln Pro Pro Ser Val Ser Gly Ala Pro Gly Gln 
1               5                   10                  15      


Arg Val Thr Ile Ser Cys Thr Gly Ser Ser Ser Asn Ile Gly Ala Asp 
            20                  25                  30          


Tyr Asn Val His Trp Tyr Gln Leu Leu Pro Gly Thr Ala Pro Lys Leu 
        35                  40                  45              


Leu Ile Tyr Gly Asn Thr Asn Arg Pro Ser Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Thr Gly Leu 
65                  70                  75                  80  


Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Gln Ser Tyr Asp Ser Ser 
                85                  90                  95      


Leu Ser Ala Ser Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly 
            100                 105                 110         


Gln Pro Lys Ala Ala Pro Ser Val Thr Leu Phe Pro Pro Ser Ser Glu 
        115                 120                 125             


Glu Leu Gln Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp Phe 
    130                 135                 140                 


Tyr Pro Gly Ala Val Thr Val Ala Trp Lys Ala Asp Ser Ser Pro Val 
145                 150                 155                 160 


Lys Ala Gly Val Glu Thr Thr Thr Pro Ser Lys Gln Ser Asn Asn Lys 
                165                 170                 175     


Tyr Ala Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys Ser 
            180                 185                 190         


His Arg Ser Tyr Ser Cys Gln Val Thr His Glu Gly Ser Thr Val Glu 
        195                 200                 205             


Lys Thr Val Ala Pro Thr Glu Cys Ser 
    210                 215         


<210>  21
<211>  1368
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HC mAb1 nucleic acid sequence

<400>  21
caggtgcagc tggtgcagtc tggcgccgaa gtgaagaaac caggcgccag cgtgaaggtg       60

tcctgcaagg ccagcggcta cagcttcacc agctacggca tcagctgggt gcgccaggct      120

cctggacagg gcctggaatg gatgggctgg atcagcacct acaagggcta cacccagtac      180

gcccagaact tccagggcag agtgaccatc accaccgaca cccctgccac caccgtgtac      240

atggaactgc ggagcctgag aagcgacgac accgccgtgt actactgcgc cagagtgctg      300

agcgagacag gctactttta ctactactat tacggcatgg acgtgtgggg ccagggcacc      360

ctcgtgacag tgtctagcgc ctctacaaag ggccccagcg tgttccctct ggcccctagc      420

agcaagagca catctggcgg aacagccgcc ctgggctgcc tcgtgaagga ctactttccc      480

gagcccgtga ccgtgtcctg gaacagcggc gctctgacct ctggcgtgca cacctttcca      540

gccgtgctgc agagcagcgg cctgtactct ctgagcagcg tcgtgactgt gcccagcagc      600

agcctgggaa cccagaccta catctgcaac gtgaaccaca agcccagcaa caccaaggtg      660

gacaagaagg tggaacccaa gagctgcgac aagacccaca cctgtccccc ttgtcctgcc      720

cctgaactgc tgggcggacc ttccgtgttc ctgttccccc caaagcccaa ggacaccctg      780

atgatcagcc ggacccccga agtgacctgc gtggtggtgg atgtgtccca cgaggaccct      840

gaagtgaagt tcaattggta cgtggacggc gtggaagtgc acaacgccaa gaccaagccc      900

agagaggaac agtacaactc cacctaccgg gtggtgtccg tgctgacagt gctgcaccag      960

gactggctga acggcaaaga gtacaagtgc aaggtgtcca acaaagccct gcctgccccc     1020

atcgagaaaa ccatcagcaa ggccaagggc cagccccgcg aaccccaggt gtacacactg     1080

cctcccagca gggacgagct gaccaagaac caggtgtccc tgacctgtct cgtgaaaggc     1140

ttctacccct ccgatatcgc cgtggaatgg gagagcaacg gccagcccga gaacaactac     1200

aagaccaccc cccctgtgct ggacagcgac ggctcattct tcctgtacag caagctgacc     1260

gtggacaagt cccggtggca gcagggcaac gtgttcagct gcagcgtgat gcacgaggcc     1320

ctgcacaacc actacacaca gaagtccctg agcctgagcc ccggctga                  1368


<210>  22
<211>  654
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LC mAb1 nucleic acid sequence

<400>  22
caggctgtcg tgacacagcc tcctagcgtg tcaggcgccc ctggccagag agtgaccatc       60

agctgtacag gcagcagcag caacatcgga gccgactaca acgtgcactg gtatcagctg      120

ctgcccggca ccgcccctaa gctgctgatc tacggcaaca ccaaccggcc tagcggcgtg      180

cccgatagat tcagcggcag caagagcggc acaagcgcca gcctggccat tactggactg      240

caggccgagg acgaggccga ctactactgc cagagctacg acagcagcct gagcgcctcc      300

gtgtttggcg gcggaacaaa gctgacagtg ctgggccagc ctaaggccgc tccaagcgtg      360

accctgttcc ctccaagcag cgaggaactg caggctaaca aggccaccct cgtgtgcctg      420

atcagcgact tctatcctgg cgccgtgacc gtggcctgga aggccgatag ctctcctgtg      480

aaggccggcg tggaaaccac cacccctagc aagcagagca acaacaaata cgccgccagc      540

agctacctga gcctgacccc cgagcagtgg aagtcccaca gatcctacag ctgccaagtg      600

acccacgagg gcagcaccgt ggaaaagaca gtggccccta ccgagtgctc ctga            654


<210>  23
<211>  455
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HC mAb3

<400>  23

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Ser Phe Thr Ser Tyr 
            20                  25                  30          


Gly Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Ser Thr Tyr Lys Gly Tyr Thr Gln Tyr Ala Gln Asn Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Thr Asp Thr Pro Ala Thr Thr Val Tyr 
65                  70                  75                  80  


Met Glu Leu Arg Ser Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Val Leu Ser Glu Thr Gly Tyr Phe Tyr Tyr Tyr Tyr Tyr Gly 
            100                 105                 110         


Met Asp Val Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser 
        115                 120                 125             


Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr 
    130                 135                 140                 


Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro 
145                 150                 155                 160 


Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val 
                165                 170                 175     


His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser 
            180                 185                 190         


Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile 
        195                 200                 205             


Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val 
    210                 215                 220                 


Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 
225                 230                 235                 240 


Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 
                245                 250                 255     


Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 
            260                 265                 270         


Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 
        275                 280                 285             


Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 
    290                 295                 300                 


Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 
305                 310                 315                 320 


Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala 
                325                 330                 335     


Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 
            340                 345                 350         


Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr 
        355                 360                 365             


Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser 
    370                 375                 380                 


Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 
385                 390                 395                 400 


Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 
                405                 410                 415     


Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 
            420                 425                 430         


Ser Cys Ser Val Met His Glu Ala Leu His Ala His Tyr Thr Gln Lys 
        435                 440                 445             


Ser Leu Ser Leu Ser Pro Gly 
    450                 455 


<210>  24
<211>  1368
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HC mAb3 nucleic acid sequence

<400>  24
caggtgcagc tggtgcagtc tggcgccgaa gtgaagaaac caggcgccag cgtgaaggtg       60

tcctgcaagg ccagcggcta cagcttcacc agctacggca tcagctgggt gcgccaggct      120

cctggacagg gcctggaatg gatgggctgg atcagcacct acaagggcta cacccagtac      180

gcccagaact tccagggcag agtgaccatc accaccgaca cccctgccac caccgtgtac      240

atggaactgc ggagcctgag aagcgacgac accgccgtgt actactgcgc cagagtgctg      300

agcgagacag gctactttta ctactactat tacggcatgg acgtgtgggg ccagggcacc      360

ctcgtgacag tgtctagcgc cagcacaaag ggccccagcg tgttccctct ggcccctagc      420

agcaagagca catctggcgg aacagccgcc ctgggctgcc tcgtgaagga ctactttccc      480

gagcccgtga ccgtgtcctg gaacagcggc gctctgacct ctggcgtgca cacctttcca      540

gccgtgctgc agagcagcgg cctgtactct ctgagcagcg tcgtgactgt gcccagcagc      600

agcctgggaa cccagaccta catctgcaac gtgaaccaca agcccagcaa caccaaggtg      660

gacaagaagg tggaacccaa gagctgcgac aagacccaca cctgtccccc ttgtcctgcc      720

cctgaactgc tgggcggacc ttccgtgttc ctgttccccc caaagcccaa ggacaccctg      780

atgatcagcc ggacccccga agtgacctgc gtggtggtgg atgtgtccca cgaggaccct      840

gaagtgaagt tcaattggta cgtggacggc gtggaagtgc acaacgccaa gaccaagccc      900

agagaggaac agtacaactc cacctaccgg gtggtgtccg tgctgacagt gctgcaccag      960

gactggctga acggcaaaga gtacaagtgc aaggtgtcca acaaagccct gcctgccccc     1020

atcgagaaaa ccatcagcaa ggccaagggc cagccccgcg aaccccaggt gtacacactg     1080

cctcccagca gggacgagct gaccaagaac caggtgtccc tgacctgtct cgtgaaaggc     1140

ttctacccct ccgatatcgc cgtggaatgg gagagcaacg gccagcccga gaacaactac     1200

aagaccaccc cccctgtgct ggacagcgac ggctcattct tcctgtacag caagctgacc     1260

gtggacaagt cccggtggca gcagggcaac gtgttcagct gcagcgtgat gcacgaggcc     1320

ctgcacgccc actacacaca gaagtccctg agcctgagcc ccggctga                  1368


<210>  25
<211>  455
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HC mAb4

<400>  25

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Ser Phe Thr Ser Tyr 
            20                  25                  30          


Gly Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Ser Thr Tyr Lys Gly Tyr Thr Gln Tyr Ala Gln Asn Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Thr Asp Thr Pro Ala Thr Thr Val Tyr 
65                  70                  75                  80  


Met Glu Leu Arg Ser Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Val Leu Ser Glu Thr Gly Tyr Phe Tyr Tyr Tyr Tyr Tyr Gly 
            100                 105                 110         


Met Asp Val Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser 
        115                 120                 125             


Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr 
    130                 135                 140                 


Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro 
145                 150                 155                 160 


Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val 
                165                 170                 175     


His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser 
            180                 185                 190         


Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile 
        195                 200                 205             


Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val 
    210                 215                 220                 


Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 
225                 230                 235                 240 


Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 
                245                 250                 255     


Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 
            260                 265                 270         


Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 
        275                 280                 285             


Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 
    290                 295                 300                 


Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Ala Val Leu His Gln 
305                 310                 315                 320 


Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala 
                325                 330                 335     


Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 
            340                 345                 350         


Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr 
        355                 360                 365             


Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser 
    370                 375                 380                 


Asp Ile Ala Val Ala Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 
385                 390                 395                 400 


Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 
                405                 410                 415     


Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 
            420                 425                 430         


Ser Cys Ser Val Met His Glu Ala Leu His Ala His Tyr Thr Gln Lys 
        435                 440                 445             


Ser Leu Ser Leu Ser Pro Gly 
    450                 455 


<210>  26
<211>  1368
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HC mAb4 nucleic acid sequence

<400>  26
caggtgcagc tggtgcagtc tggcgccgaa gtgaagaaac caggcgccag cgtgaaggtg       60

tcctgcaagg ccagcggcta cagcttcacc agctacggca tcagctgggt gcgccaggct      120

cctggacagg gcctggaatg gatgggctgg atcagcacct acaagggcta cacccagtac      180

gcccagaact tccagggcag agtgaccatc accaccgaca cccctgccac caccgtgtac      240

atggaactgc ggagcctgag aagcgacgac accgccgtgt actactgcgc cagagtgctg      300

agcgagacag gctactttta ctactactat tacggcatgg acgtgtgggg ccagggcacc      360

ctcgtgacag tgtctagcgc cagcacaaag ggccccagcg tgttccctct ggcccctagc      420

agcaagagca catctggcgg aacagccgcc ctgggctgcc tcgtgaagga ctactttccc      480

gagcccgtga ccgtgtcctg gaacagcggc gctctgacct ctggcgtgca cacctttcca      540

gccgtgctgc agagcagcgg cctgtactct ctgagcagcg tcgtgactgt gcccagcagc      600

agcctgggaa cccagaccta catctgcaac gtgaaccaca agcccagcaa caccaaggtg      660

gacaagaagg tggaacccaa gagctgcgac aagacccaca cctgtccccc ttgtcctgcc      720

cctgaactgc tgggcggacc ttccgtgttc ctgttccccc caaagcccaa ggacaccctg      780

atgatcagcc ggacccccga agtgacctgc gtggtggtgg atgtgtccca cgaggaccct      840

gaagtgaagt tcaattggta cgtggacggc gtggaagtgc acaacgccaa gaccaagccc      900

agagaggaac agtacaactc cacctaccgg gtggtgtccg tgctggctgt gctgcaccag      960

gactggctga acggcaaaga gtacaagtgc aaggtgtcca acaaagccct gcctgccccc     1020

atcgagaaaa ccatcagcaa ggccaagggc cagccccgcg aaccccaggt gtacacactg     1080

cctcccagca gggacgagct gaccaagaac caggtgtccc tgacctgtct cgtgaaaggc     1140

ttctacccct ccgatatcgc cgtggcctgg gagagcaacg gccagcccga gaacaactac     1200

aagaccaccc cccctgtgct ggacagcgac ggctcattct tcctgtacag caagctgacc     1260

gtggacaagt cccggtggca gcagggcaac gtgttcagct gcagcgtgat gcacgaggcc     1320

ctgcacgccc actacacaca gaagtccctg agcctgagcc ccggctga                  1368


<210>  27
<211>  455
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HC mAb5

<400>  27

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Ser Phe Thr Ser Tyr 
            20                  25                  30          


Gly Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Ser Thr Tyr Lys Gly Tyr Thr Gln Tyr Ala Gln Asn Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Thr Asp Thr Pro Ala Thr Thr Val Tyr 
65                  70                  75                  80  


Met Glu Leu Arg Ser Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Val Leu Ser Glu Thr Gly Tyr Phe Tyr Tyr Tyr Tyr Tyr Gly 
            100                 105                 110         


Met Asp Val Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser 
        115                 120                 125             


Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr 
    130                 135                 140                 


Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro 
145                 150                 155                 160 


Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val 
                165                 170                 175     


His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser 
            180                 185                 190         


Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile 
        195                 200                 205             


Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val 
    210                 215                 220                 


Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 
225                 230                 235                 240 


Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 
                245                 250                 255     


Lys Asp Gln Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 
            260                 265                 270         


Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 
        275                 280                 285             


Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 
    290                 295                 300                 


Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 
305                 310                 315                 320 


Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala 
                325                 330                 335     


Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 
            340                 345                 350         


Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr 
        355                 360                 365             


Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser 
    370                 375                 380                 


Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 
385                 390                 395                 400 


Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 
                405                 410                 415     


Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 
            420                 425                 430         


Ser Cys Ser Val Leu His Glu Ala Leu His Asn His Tyr Thr Gln Lys 
        435                 440                 445             


Ser Leu Ser Leu Ser Pro Gly 
    450                 455 


<210>  28
<211>  1368
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HC mAb5 nucleic acid sequence

<400>  28
caggtgcagc tggtgcagtc tggcgccgaa gtgaagaaac caggcgccag cgtgaaggtg       60

tcctgcaagg ccagcggcta cagcttcacc agctacggca tcagctgggt gcgccaggct      120

cctggacagg gcctggaatg gatgggctgg atcagcacct acaagggcta cacccagtac      180

gcccagaact tccagggcag agtgaccatc accaccgaca cccctgccac caccgtgtac      240

atggaactgc ggagcctgag aagcgacgac accgccgtgt actactgcgc cagagtgctg      300

agcgagacag gctactttta ctactactat tacggcatgg acgtgtgggg ccagggcacc      360

ctcgtgacag tgtctagcgc cagcacaaag ggccccagcg tgttccctct ggcccctagc      420

agcaagagca catctggcgg aacagccgcc ctgggctgcc tcgtgaagga ctactttccc      480

gagcccgtga ccgtgtcctg gaacagcggc gctctgacct ctggcgtgca cacctttcca      540

gccgtgctgc agagcagcgg cctgtactct ctgagcagcg tcgtgactgt gcccagcagc      600

agcctgggaa cccagaccta catctgcaac gtgaaccaca agcccagcaa caccaaggtg      660

gacaagaagg tggaacccaa gagctgcgac aagacccaca cctgtccccc ttgtcctgcc      720

cctgaactgc tgggcggacc ttccgtgttc ctgttccccc caaagcccaa ggaccagctg      780

atgatcagcc ggacccccga agtgacctgc gtggtggtgg atgtgtccca cgaggaccct      840

gaagtgaagt tcaattggta cgtggacggc gtggaagtgc acaacgccaa gaccaagccc      900

agagaggaac agtacaactc cacctaccgg gtggtgtccg tgctgacagt gctgcaccag      960

gactggctga acggcaaaga gtacaagtgc aaggtgtcca acaaagccct gcctgccccc     1020

atcgagaaaa ccatcagcaa ggccaagggc cagccccgcg aaccccaggt gtacacactg     1080

cctcccagca gggacgagct gaccaagaac caggtgtccc tgacctgtct cgtgaaaggc     1140

ttctacccct ccgatatcgc cgtggaatgg gagagcaacg gccagcccga gaacaactac     1200

aagaccaccc cccctgtgct ggacagcgac ggctcattct tcctgtacag caagctgacc     1260

gtggacaagt cccggtggca gcagggcaac gtgttcagct gcagcgtgct gcacgaggcc     1320

ctgcacaacc actacacaca gaagtccctg agcctgagcc ccggctga                  1368


<210>  29
<211>  455
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HC mAb6

<400>  29

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Ser Phe Thr Ser Tyr 
            20                  25                  30          


Gly Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Ser Thr Tyr Lys Gly Tyr Thr Gln Tyr Ala Gln Asn Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Thr Asp Thr Pro Ala Thr Thr Val Tyr 
65                  70                  75                  80  


Met Glu Leu Arg Ser Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Val Leu Ser Glu Thr Gly Tyr Phe Tyr Tyr Tyr Tyr Tyr Gly 
            100                 105                 110         


Met Asp Val Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser 
        115                 120                 125             


Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr 
    130                 135                 140                 


Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro 
145                 150                 155                 160 


Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val 
                165                 170                 175     


His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser 
            180                 185                 190         


Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile 
        195                 200                 205             


Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val 
    210                 215                 220                 


Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 
225                 230                 235                 240 


Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 
                245                 250                 255     


Lys Asp Thr Leu Tyr Ile Thr Arg Glu Pro Glu Val Thr Cys Val Val 
            260                 265                 270         


Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 
        275                 280                 285             


Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 
    290                 295                 300                 


Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 
305                 310                 315                 320 


Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala 
                325                 330                 335     


Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 
            340                 345                 350         


Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr 
        355                 360                 365             


Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser 
    370                 375                 380                 


Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 
385                 390                 395                 400 


Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 
                405                 410                 415     


Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 
            420                 425                 430         


Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 
        435                 440                 445             


Ser Leu Ser Leu Ser Pro Gly 
    450                 455 


<210>  30
<211>  1368
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HC mAb6 nucleic acid sequence

<400>  30
caggtgcagc tggtgcagtc tggcgccgaa gtgaagaaac caggcgccag cgtgaaggtg       60

tcctgcaagg ccagcggcta cagcttcacc agctacggca tcagctgggt gcgccaggct      120

cctggacagg gcctggaatg gatgggctgg atcagcacct acaagggcta cacccagtac      180

gcccagaact tccagggcag agtgaccatc accaccgaca cccctgccac caccgtgtac      240

atggaactgc ggagcctgag aagcgacgac accgccgtgt actactgcgc cagagtgctg      300

agcgagacag gctactttta ctactactat tacggcatgg acgtgtgggg ccagggcacc      360

ctcgtgacag tgtctagcgc cagcacaaag ggccccagcg tgttccctct ggcccctagc      420

agcaagagca catctggcgg aacagccgcc ctgggctgcc tcgtgaagga ctactttccc      480

gagcccgtga ccgtgtcctg gaacagcggc gctctgacct ctggcgtgca cacctttcca      540

gccgtgctgc agagcagcgg cctgtactct ctgagcagcg tcgtgactgt gcccagcagc      600

agcctgggaa cccagaccta catctgcaac gtgaaccaca agcccagcaa caccaaggtg      660

gacaagaagg tggaacccaa gagctgcgac aagacccaca cctgtccccc ttgtcctgcc      720

cctgaactgc tgggcggacc ttccgtgttc ctgttccccc caaagcccaa ggacaccctg      780

tacatcaccc gcgagcccga agtgacctgc gtggtggtgg atgtgtccca cgaggaccct      840

gaagtgaagt tcaattggta cgtggacggc gtggaagtgc acaacgccaa gaccaagccc      900

agagaggaac agtacaactc cacctaccgg gtggtgtccg tgctgacagt gctgcaccag      960

gactggctga acggcaaaga gtacaagtgc aaggtgtcca acaaagccct gcctgccccc     1020

atcgagaaaa ccatcagcaa ggccaagggc cagccccgcg aaccccaggt gtacacactg     1080

cctcccagca gggacgagct gaccaagaac caggtgtccc tgacctgtct cgtgaaaggc     1140

ttctacccct ccgatatcgc cgtggaatgg gagagcaacg gccagcccga gaacaactac     1200

aagaccaccc cccctgtgct ggacagcgac ggctcattct tcctgtacag caagctgacc     1260

gtggacaagt cccggtggca gcagggcaac gtgttcagct gcagcgtgat gcacgaggcc     1320

ctgcacaacc actacacaca gaagtccctg agcctgagcc ccggctga                  1368


<210>  31
<211>  455
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HC mAb7

<400>  31

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Ser Phe Thr Ser Tyr 
            20                  25                  30          


Gly Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Ser Thr Tyr Lys Gly Tyr Thr Gln Tyr Ala Gln Asn Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Thr Asp Thr Pro Ala Thr Thr Val Tyr 
65                  70                  75                  80  


Met Glu Leu Arg Ser Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Val Leu Ser Glu Thr Gly Tyr Phe Tyr Tyr Tyr Tyr Tyr Gly 
            100                 105                 110         


Met Asp Val Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser 
        115                 120                 125             


Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr 
    130                 135                 140                 


Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro 
145                 150                 155                 160 


Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val 
                165                 170                 175     


His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser 
            180                 185                 190         


Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile 
        195                 200                 205             


Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val 
    210                 215                 220                 


Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 
225                 230                 235                 240 


Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 
                245                 250                 255     


Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 
            260                 265                 270         


Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 
        275                 280                 285             


Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 
    290                 295                 300                 


Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 
305                 310                 315                 320 


Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala 
                325                 330                 335     


Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 
            340                 345                 350         


Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr 
        355                 360                 365             


Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser 
    370                 375                 380                 


Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 
385                 390                 395                 400 


Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 
                405                 410                 415     


Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 
            420                 425                 430         


Ser Cys Ser Val Leu His Glu Ala Leu His Ser His Tyr Thr Gln Lys 
        435                 440                 445             


Ser Leu Ser Leu Ser Pro Gly 
    450                 455 


<210>  32
<211>  1368
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HC mAb7 nucleic acid sequence

<400>  32
caggtgcagc tggtgcagtc tggcgccgaa gtgaagaaac caggcgccag cgtgaaggtg       60

tcctgcaagg ccagcggcta cagcttcacc agctacggca tcagctgggt gcgccaggct      120

cctggacagg gcctggaatg gatgggctgg atcagcacct acaagggcta cacccagtac      180

gcccagaact tccagggcag agtgaccatc accaccgaca cccctgccac caccgtgtac      240

atggaactgc ggagcctgag aagcgacgac accgccgtgt actactgcgc cagagtgctg      300

agcgagacag gctactttta ctactactat tacggcatgg acgtgtgggg ccagggcacc      360

ctcgtgacag tgtctagcgc cagcacaaag ggccccagcg tgttccctct ggcccctagc      420

agcaagagca catctggcgg aacagccgcc ctgggctgcc tcgtgaagga ctactttccc      480

gagcccgtga ccgtgtcctg gaacagcggc gctctgacct ctggcgtgca cacctttcca      540

gccgtgctgc agagcagcgg cctgtactct ctgagcagcg tcgtgactgt gcccagcagc      600

agcctgggaa cccagaccta catctgcaac gtgaaccaca agcccagcaa caccaaggtg      660

gacaagaagg tggaacccaa gagctgcgac aagacccaca cctgtccccc ttgtcctgcc      720

cctgaactgc tgggcggacc ttccgtgttc ctgttccccc caaagcccaa ggacaccctg      780

atgatcagcc ggacccccga agtgacctgc gtggtggtgg atgtgtccca cgaggaccct      840

gaagtgaagt tcaattggta cgtggacggc gtggaagtgc acaacgccaa gaccaagccc      900

agagaggaac agtacaactc cacctaccgg gtggtgtccg tgctgacagt gctgcaccag      960

gactggctga acggcaaaga gtacaagtgc aaggtgtcca acaaagccct gcctgccccc     1020

atcgagaaaa ccatcagcaa ggccaagggc cagccccgcg aaccccaggt gtacacactg     1080

cctcccagca gggacgagct gaccaagaac caggtgtccc tgacctgtct cgtgaaaggc     1140

ttctacccct ccgatatcgc cgtggaatgg gagagcaacg gccagcccga gaacaactac     1200

aagaccaccc cccctgtgct ggacagcgac ggctcattct tcctgtacag caagctgacc     1260

gtggacaagt cccggtggca gcagggcaac gtgttcagct gcagcgtgct gcacgaggcc     1320

ctgcacagcc actacacaca gaagtccctg agcctgagcc ccggctga                  1368


<210>  33
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mAb2 CDRH3


<220>
<221>  MISC_FEATURE
<222>  (8)..(8)
<223>  X = any amino acid except M

<220>
<221>  MISC_FEATURE
<222>  (12)..(12)
<223>  X = any amino acid except N

<220>
<221>  MISC_FEATURE
<222>  (13)..(13)
<223>  X = any amino acid except G

<400>  33

Ala Thr Gly Gly Phe Trp Ser Xaa Ile Gly Gly Xaa Xaa Val Asp Tyr 
1               5                   10                  15      


<210>  34
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mAb10 CDRH3

<400>  34

Ala Thr Gly Gly Phe Trp Ser Ile Ile Gly Gly Asn Gly Val Asp Tyr 
1               5                   10                  15      


<210>  35
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mAb11 CDRH3

<400>  35

Ala Thr Gly Gly Phe Trp Ser Met Ile Gly Gly Gln Gly Val Asp Tyr 
1               5                   10                  15      


<210>  36
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mAb12 CDRH3

<400>  36

Ala Thr Gly Gly Phe Trp Ser Met Ile Gly Gly Asn Ala Val Asp Tyr 
1               5                   10                  15      


<210>  37
<211>  452
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HC mAb2

<400>  37

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Val Ser Gly Tyr Ile Leu Ser Lys Leu 
            20                  25                  30          


Ser Val His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Gly Ser Glu Arg Glu Asp Gly Glu Thr Val Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Ile Ser Leu Thr Glu Asp Thr Ser Ile Glu Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Ser Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Thr Gly Gly Phe Trp Ser Met Ile Gly Gly Asn Gly Val Asp Tyr 
            100                 105                 110         


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly 
        115                 120                 125             


Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly 
    130                 135                 140                 


Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val 
145                 150                 155                 160 


Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe 
                165                 170                 175     


Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val 
            180                 185                 190         


Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val 
        195                 200                 205             


Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys 
    210                 215                 220                 


Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu 
225                 230                 235                 240 


Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr 
                245                 250                 255     


Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val 
            260                 265                 270         


Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val 
        275                 280                 285             


Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser 
    290                 295                 300                 


Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu 
305                 310                 315                 320 


Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala 
                325                 330                 335     


Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro 
            340                 345                 350         


Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln 
        355                 360                 365             


Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala 
    370                 375                 380                 


Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr 
385                 390                 395                 400 


Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu 
                405                 410                 415     


Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser 
            420                 425                 430         


Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser 
        435                 440                 445             


Leu Ser Pro Gly 
    450         


<210>  38
<211>  214
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LC mAb2

<400>  38

Gln Ala Val Val Thr Gln Ser Pro Ser Ser Leu Pro Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Ile Arg Asn Asn 
            20                  25                  30          


Leu Gly Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Glu Arg Leu Ile 
        35                  40                  45              


Tyr Gly Thr Ser Asn Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Leu Gln His Asn Ser Tyr Pro Pro 
                85                  90                  95      


Thr Phe Gly Arg Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala Ala 
            100                 105                 110         


Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             


Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 


Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 


Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     


Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         


Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             


Phe Asn Arg Gly Glu Cys 
    210                 


<210>  39
<211>  1359
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HC mAb2 nucleic acid

<400>  39
caggtgcagc tggtgcagtc tggcgccgaa gtgaagaaac caggcgccag cgtgaaggtg       60

tcctgcaagg tgtccggcta catcctgagc aagctgagcg tgcactgggt gcgccaggcc      120

cctggaaaag gcctggaatg gatgggcggc agcgagcgcg aagatggcga gacagtgtac      180

gcccagaagt tccagggccg gatcagcctg accgaggaca cctctatcga gacagcctac      240

atggaactga gcagcctgtc cagcgaggat accgccgtgt actactgtgc caccggcggc      300

ttttggagca tgatcggcgg aaacggcgtg gactattggg gccagggaac cctcgtgacc      360

gtgtctagcg cctctacaaa gggccccagc gtgttccctc tggcccctag cagcaagagc      420

acatctggcg gaacagccgc cctgggctgc ctcgtgaagg actactttcc cgagcccgtg      480

acagtgtcct ggaacagcgg agccctgacc agcggagtgc atacctttcc agccgtgctg      540

cagagcagcg gcctgtactc tctgagcagc gtcgtgactg tgcccagcag cagcctggga      600

acccagacct acatctgcaa cgtgaaccac aagcccagca acaccaaggt ggacaagaag      660

gtggaaccca agagctgcga caagacccac acctgtcccc cttgtcctgc ccctgaactg      720

ctgggaggcc cttccgtgtt cctgttcccc ccaaagccca aggacaccct gatgatcagc      780

cggacccccg aagtgacctg cgtggtggtg gatgtgtccc acgaggaccc tgaagtgaag      840

ttcaattggt acgtggacgg ggtggaagtg cataacgcca agaccaagcc cagagaggaa      900

cagtacaaca gcacctaccg ggtggtgtcc gtgctgacag tgctgcacca ggactggctg      960

aacggcaaag agtacaagtg caaagtgtcc aacaaggccc tgcctgcccc catcgagaaa     1020

accatcagca aggccaaggg ccagccccgc gaaccccagg tgtacacact gcccccaagc     1080

agggacgagc tgaccaagaa ccaggtgtcc ctgacctgtc tcgtgaaagg cttctacccc     1140

tccgatatcg ccgtggaatg ggagagcaac ggccagcccg agaacaacta caagaccacc     1200

ccccctgtgc tggacagcga cggctcattc ttcctgtact ccaagctgac cgtggacaag     1260

tcccggtggc agcagggcaa cgtgttcagc tgcagcgtga tgcacgaggc cctgcacaac     1320

cactacaccc agaagtccct gagcctgagc cccggctga                            1359


<210>  40
<211>  645
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LC mAb2 nucleic acid sequence

<400>  40
caggctgtcg tgacacagag cccctctagc ctgcctgcca gcgtgggcga cagagtgacc       60

atcacctgta gagccagcca ggacatccgg aacaacctgg gctggtatca gcagaagccc      120

ggcaaggccc ccgagagact gatctacggc accagcaatc tgcagtccgg cgtgcccagc      180

agattttccg gctctggcag cggcaccgag ttcaccctga caatcagcag cctgcagccc      240

gaggacttcg ccacctacta ctgcctgcag cacaacagct acccccccac ctttggcaga      300

ggcaccaagg tggaaatcaa gcggacagtg gccgctccca gcgtgttcat cttcccacct      360

agcgacgagc agctgaagtc cggcacagcc tctgtcgtgt gcctgctgaa caacttctac      420

ccccgcgagg ccaaggtgca gtggaaggtg gacaatgccc tgcagtctgg caacagccag      480

gaaagcgtga ccgagcagga cagcaaggac tccacctaca gcctgtccag caccctgacc      540

ctgagcaagg ccgactacga gaagcacaag gtgtacgcct gcgaagtgac ccaccagggc      600

ctgagcagcc ctgtgaccaa gagcttcaac cggggcgagt gctga                      645


<210>  41
<211>  452
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HC mAb8

<400>  41

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Val Ser Gly Tyr Ile Leu Ser Lys Leu 
            20                  25                  30          


Ser Val His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Gly Ser Glu Arg Glu Asp Gly Glu Thr Val Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Ile Ser Leu Thr Glu Asp Thr Ser Ile Glu Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Ser Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Thr Gly Gly Phe Trp Ser Met Ile Gly Gly Asn Gly Val Asp Tyr 
            100                 105                 110         


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly 
        115                 120                 125             


Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly 
    130                 135                 140                 


Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val 
145                 150                 155                 160 


Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe 
                165                 170                 175     


Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val 
            180                 185                 190         


Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val 
        195                 200                 205             


Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys 
    210                 215                 220                 


Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu 
225                 230                 235                 240 


Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr 
                245                 250                 255     


Leu Tyr Ile Thr Arg Glu Pro Glu Val Thr Cys Val Val Val Asp Val 
            260                 265                 270         


Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val 
        275                 280                 285             


Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser 
    290                 295                 300                 


Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu 
305                 310                 315                 320 


Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala 
                325                 330                 335     


Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro 
            340                 345                 350         


Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln 
        355                 360                 365             


Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala 
    370                 375                 380                 


Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr 
385                 390                 395                 400 


Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu 
                405                 410                 415     


Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser 
            420                 425                 430         


Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser 
        435                 440                 445             


Leu Ser Pro Gly 
    450         


<210>  42
<211>  1359
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HC mAb8 nucleic acid sequence

<400>  42
caggtgcagc tggtgcagtc tggcgccgaa gtgaagaaac caggcgccag cgtgaaggtg       60

tcctgcaagg tgtccggcta catcctgagc aagctgagcg tgcactgggt gcgccaggcc      120

cctggaaaag gcctggaatg gatgggcggc agcgagcgcg aagatggcga gacagtgtac      180

gcccagaagt tccagggccg gatcagcctg accgaggaca cctctatcga gacagcctac      240

atggaactga gcagcctgtc cagcgaggat accgccgtgt actactgtgc caccggcggc      300

ttttggagca tgatcggcgg aaacggcgtg gactattggg gccagggaac cctcgtgacc      360

gtgtctagcg ccagcacaaa gggccccagc gtgttccctc tggcccctag cagcaagagc      420

acatctggcg gaacagccgc cctgggctgc ctcgtgaagg actactttcc cgagcccgtg      480

acagtgtcct ggaacagcgg agccctgacc agcggcgtgc acacatttcc agccgtgctg      540

cagagcagcg gcctgtactc tctgagcagc gtcgtgactg tgcccagcag cagcctggga      600

acccagacct acatctgcaa cgtgaaccac aagcccagca acaccaaggt ggacaagaag      660

gtggaaccca agagctgcga caagacccac acctgtcccc cttgtcctgc ccctgaactg      720

ctgggaggcc cttccgtgtt cctgttcccc ccaaagccca aggacaccct gtacatcacc      780

cgcgagcccg aagtgacctg cgtggtggtg gatgtgtccc acgaggaccc tgaagtgaag      840

ttcaattggt acgtggacgg ggtggaagtg cacaacgcca agaccaagcc cagagaggaa      900

cagtacaaca gcacctaccg ggtggtgtcc gtgctgacag tgctgcacca ggactggctg      960

aacggcaaag agtacaagtg caaagtgtcc aacaaggccc tgcctgcccc catcgagaaa     1020

accatcagca aggccaaggg ccagccccgc gaaccccagg tgtacacact gcccccaagc     1080

agggacgagc tgaccaagaa ccaggtgtcc ctgacctgtc tcgtgaaagg cttctacccc     1140

tccgatatcg ccgtggaatg ggagagcaac ggccagcccg agaacaacta caagaccacc     1200

ccccctgtgc tggacagcga cggctcattc ttcctgtact ccaagctgac cgtggacaag     1260

tcccggtggc agcagggcaa cgtgttcagc tgtagcgtga tgcacgaggc cctgcacaac     1320

cactacaccc agaagtccct gagcctgagc cccggctga                            1359


<210>  43
<211>  452
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HC mAb9

<400>  43

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Val Ser Gly Tyr Ile Leu Ser Lys Leu 
            20                  25                  30          


Ser Val His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Gly Ser Glu Arg Glu Asp Gly Glu Thr Val Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Ile Ser Leu Thr Glu Asp Thr Ser Ile Glu Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Ser Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Thr Gly Gly Phe Trp Ser Met Ile Gly Gly Asn Gly Val Asp Tyr 
            100                 105                 110         


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly 
        115                 120                 125             


Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly 
    130                 135                 140                 


Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val 
145                 150                 155                 160 


Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe 
                165                 170                 175     


Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val 
            180                 185                 190         


Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val 
        195                 200                 205             


Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys 
    210                 215                 220                 


Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu 
225                 230                 235                 240 


Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr 
                245                 250                 255     


Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val 
            260                 265                 270         


Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val 
        275                 280                 285             


Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser 
    290                 295                 300                 


Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu 
305                 310                 315                 320 


Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala 
                325                 330                 335     


Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro 
            340                 345                 350         


Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln 
        355                 360                 365             


Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala 
    370                 375                 380                 


Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr 
385                 390                 395                 400 


Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu 
                405                 410                 415     


Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser 
            420                 425                 430         


Val Leu His Glu Ala Leu His Ser His Tyr Thr Gln Lys Ser Leu Ser 
        435                 440                 445             


Leu Ser Pro Gly 
    450         


<210>  44
<211>  1359
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HC mAb9 nucleic acid sequence

<400>  44
caggtgcagc tggtgcagtc tggcgccgaa gtgaagaaac caggcgccag cgtgaaggtg       60

tcctgcaagg tgtccggcta catcctgagc aagctgagcg tgcactgggt gcgccaggcc      120

cctggaaaag gcctggaatg gatgggcggc agcgagcgcg aagatggcga gacagtgtac      180

gcccagaagt tccagggccg gatcagcctg accgaggaca cctctatcga gacagcctac      240

atggaactga gcagcctgtc cagcgaggat accgccgtgt actactgtgc caccggcggc      300

ttttggagca tgatcggcgg aaacggcgtg gactattggg gccagggaac cctcgtgacc      360

gtgtctagcg ccagcacaaa gggccccagc gtgttccctc tggcccctag cagcaagagc      420

acatctggcg gaacagccgc cctgggctgc ctcgtgaagg actactttcc cgagcccgtg      480

acagtgtcct ggaacagcgg agccctgacc agcggcgtgc acacatttcc agccgtgctg      540

cagagcagcg gcctgtactc tctgagcagc gtcgtgactg tgcccagcag cagcctggga      600

acccagacct acatctgcaa cgtgaaccac aagcccagca acaccaaggt ggacaagaag      660

gtggaaccca agagctgcga caagacccac acctgtcccc cttgtcctgc ccctgaactg      720

ctgggaggcc cttccgtgtt cctgttcccc ccaaagccca aggacaccct gatgatcagc      780

cggacccccg aagtgacctg cgtggtggtg gatgtgtccc acgaggaccc tgaagtgaag      840

ttcaattggt acgtggacgg ggtggaagtg cacaacgcca agaccaagcc cagagaggaa      900

cagtacaaca gcacctaccg ggtggtgtcc gtgctgacag tgctgcacca ggactggctg      960

aacggcaaag agtacaagtg caaagtgtcc aacaaggccc tgcctgcccc catcgagaaa     1020

accatcagca aggccaaggg ccagccccgc gaaccccagg tgtacacact gcccccaagc     1080

agggacgagc tgaccaagaa ccaggtgtcc ctgacctgtc tcgtgaaagg cttctacccc     1140

tccgatatcg ccgtggaatg ggagagcaac ggccagcccg agaacaacta caagaccacc     1200

ccccctgtgc tggacagcga cggctcattc ttcctgtact ccaagctgac cgtggacaag     1260

tcccggtggc agcagggcaa cgtgttcagc tgtagcgtgc tgcacgaggc cctgcacagc     1320

cactacaccc agaagtccct gagcctgagc cccggctga                            1359


<210>  45
<211>  452
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HC mAb10

<400>  45

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Val Ser Gly Tyr Ile Leu Ser Lys Leu 
            20                  25                  30          


Ser Val His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Gly Ser Glu Arg Glu Asp Gly Glu Thr Val Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Ile Ser Leu Thr Glu Asp Thr Ser Ile Glu Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Ser Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Thr Gly Gly Phe Trp Ser Ile Ile Gly Gly Asn Gly Val Asp Tyr 
            100                 105                 110         


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly 
        115                 120                 125             


Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly 
    130                 135                 140                 


Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val 
145                 150                 155                 160 


Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe 
                165                 170                 175     


Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val 
            180                 185                 190         


Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val 
        195                 200                 205             


Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys 
    210                 215                 220                 


Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu 
225                 230                 235                 240 


Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr 
                245                 250                 255     


Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val 
            260                 265                 270         


Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val 
        275                 280                 285             


Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser 
    290                 295                 300                 


Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu 
305                 310                 315                 320 


Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala 
                325                 330                 335     


Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro 
            340                 345                 350         


Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln 
        355                 360                 365             


Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala 
    370                 375                 380                 


Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr 
385                 390                 395                 400 


Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu 
                405                 410                 415     


Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser 
            420                 425                 430         


Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser 
        435                 440                 445             


Leu Ser Pro Gly 
    450         


<210>  46
<211>  1359
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HC mAb10 nucleic acid sequence

<400>  46
caggtgcagc tggtgcagtc tggcgccgaa gtgaagaaac caggcgccag cgtgaaggtg       60

tcctgcaagg tgtccggcta catcctgagc aagctgagcg tgcactgggt gcgccaggcc      120

cctggaaaag gcctggaatg gatgggcggc agcgagcgcg aagatggcga gacagtgtac      180

gcccagaagt tccagggccg gatcagcctg accgaggaca cctctatcga gacagcctac      240

atggaactga gcagcctgtc cagcgaggat accgccgtgt actactgtgc caccggcggc      300

ttttggagca tcatcggcgg aaacggcgtg gactattggg gccagggaac cctcgtgacc      360

gtgtctagcg cctctacaaa gggccccagc gtgttccctc tggcccctag cagcaagagc      420

acatctggcg gaacagccgc cctgggctgc ctcgtgaagg actactttcc cgagcccgtg      480

acagtgtcct ggaacagcgg agccctgacc agcggagtgc atacctttcc agccgtgctg      540

cagagcagcg gcctgtactc tctgagcagc gtcgtgactg tgcccagcag cagcctggga      600

acccagacct acatctgcaa cgtgaaccac aagcccagca acaccaaggt ggacaagaag      660

gtggaaccca agagctgcga caagacccac acctgtcccc cttgtcctgc ccctgaactg      720

ctgggaggcc cttccgtgtt cctgttcccc ccaaagccca aggacaccct gatgatcagc      780

cggacccccg aagtgacctg cgtggtggtg gatgtgtccc acgaggaccc tgaagtgaag      840

ttcaattggt acgtggacgg ggtggaagtg cataacgcca agaccaagcc cagagaggaa      900

cagtacaaca gcacctaccg ggtggtgtcc gtgctgacag tgctgcacca ggactggctg      960

aacggcaaag agtacaagtg caaagtgtcc aacaaggccc tgcctgcccc catcgagaaa     1020

accatcagca aggccaaggg ccagccccgc gaaccccagg tgtacacact gcccccaagc     1080

agggacgagc tgaccaagaa ccaggtgtcc ctgacctgtc tcgtgaaagg cttctacccc     1140

tccgatatcg ccgtggaatg ggagagcaac ggccagcccg agaacaacta caagaccacc     1200

ccccctgtgc tggacagcga cggctcattc ttcctgtact ccaagctgac cgtggacaag     1260

tcccggtggc agcagggcaa cgtgttcagc tgcagcgtga tgcacgaggc cctgcacaac     1320

cactacaccc agaagtccct gagcctgagc cccggctga                            1359


<210>  47
<211>  452
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HC mAb11

<400>  47

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Val Ser Gly Tyr Ile Leu Ser Lys Leu 
            20                  25                  30          


Ser Val His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Gly Ser Glu Arg Glu Asp Gly Glu Thr Val Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Ile Ser Leu Thr Glu Asp Thr Ser Ile Glu Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Ser Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Thr Gly Gly Phe Trp Ser Met Ile Gly Gly Gln Gly Val Asp Tyr 
            100                 105                 110         


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly 
        115                 120                 125             


Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly 
    130                 135                 140                 


Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val 
145                 150                 155                 160 


Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe 
                165                 170                 175     


Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val 
            180                 185                 190         


Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val 
        195                 200                 205             


Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys 
    210                 215                 220                 


Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu 
225                 230                 235                 240 


Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr 
                245                 250                 255     


Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val 
            260                 265                 270         


Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val 
        275                 280                 285             


Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser 
    290                 295                 300                 


Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu 
305                 310                 315                 320 


Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala 
                325                 330                 335     


Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro 
            340                 345                 350         


Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln 
        355                 360                 365             


Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala 
    370                 375                 380                 


Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr 
385                 390                 395                 400 


Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu 
                405                 410                 415     


Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser 
            420                 425                 430         


Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser 
        435                 440                 445             


Leu Ser Pro Gly 
    450         


<210>  48
<211>  1359
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HC mAb11 nucleic acid sequence

<400>  48
caggtgcagc tggtgcagtc tggcgccgaa gtgaagaaac caggcgccag cgtgaaggtg       60

tcctgcaagg tgtccggcta catcctgagc aagctgagcg tgcactgggt gcgccaggcc      120

cctggaaaag gcctggaatg gatgggcggc agcgagcgcg aagatggcga gacagtgtac      180

gcccagaagt tccagggccg gatcagcctg accgaggaca cctctatcga gacagcctac      240

atggaactga gcagcctgtc cagcgaggat accgccgtgt actactgtgc caccggcggc      300

ttttggagca tgatcggcgg acagggcgtg gactattggg gccagggaac cctcgtgacc      360

gtgtctagcg cctctacaaa gggccccagc gtgttccctc tggcccctag cagcaagagc      420

acatctggcg gaacagccgc cctgggctgc ctcgtgaagg actactttcc cgagcccgtg      480

acagtgtcct ggaacagcgg agccctgacc agcggagtgc atacctttcc agccgtgctg      540

cagagcagcg gcctgtactc tctgagcagc gtcgtgactg tgcccagcag cagcctggga      600

acccagacct acatctgcaa cgtgaaccac aagcccagca acaccaaggt ggacaagaag      660

gtggaaccca agagctgcga caagacccac acctgtcccc cttgtcctgc ccctgaactg      720

ctgggaggcc cttccgtgtt cctgttcccc ccaaagccca aggacaccct gatgatcagc      780

cggacccccg aagtgacctg cgtggtggtg gatgtgtccc acgaggaccc tgaagtgaag      840

ttcaattggt acgtggacgg ggtggaagtg cataacgcca agaccaagcc cagagaggaa      900

cagtacaaca gcacctaccg ggtggtgtcc gtgctgacag tgctgcacca ggactggctg      960

aacggcaaag agtacaagtg caaagtgtcc aacaaggccc tgcctgcccc catcgagaaa     1020

accatcagca aggccaaggg ccagccccgc gaaccccagg tgtacacact gcccccaagc     1080

agggacgagc tgaccaagaa ccaggtgtcc ctgacctgtc tcgtgaaagg cttctacccc     1140

tccgatatcg ccgtggaatg ggagagcaac ggccagcccg agaacaacta caagaccacc     1200

ccccctgtgc tggacagcga cggctcattc ttcctgtact ccaagctgac cgtggacaag     1260

tcccggtggc agcagggcaa cgtgttcagc tgcagcgtga tgcacgaggc cctgcacaac     1320

cactacaccc agaagtccct gagcctgagc cccggctga                            1359


<210>  49
<211>  452
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HC mAb12

<400>  49

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Val Ser Gly Tyr Ile Leu Ser Lys Leu 
            20                  25                  30          


Ser Val His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Gly Ser Glu Arg Glu Asp Gly Glu Thr Val Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Ile Ser Leu Thr Glu Asp Thr Ser Ile Glu Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Ser Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Thr Gly Gly Phe Trp Ser Met Ile Gly Gly Asn Ala Val Asp Tyr 
            100                 105                 110         


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly 
        115                 120                 125             


Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly 
    130                 135                 140                 


Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val 
145                 150                 155                 160 


Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe 
                165                 170                 175     


Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val 
            180                 185                 190         


Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val 
        195                 200                 205             


Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys 
    210                 215                 220                 


Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu 
225                 230                 235                 240 


Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr 
                245                 250                 255     


Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val 
            260                 265                 270         


Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val 
        275                 280                 285             


Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser 
    290                 295                 300                 


Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu 
305                 310                 315                 320 


Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala 
                325                 330                 335     


Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro 
            340                 345                 350         


Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln 
        355                 360                 365             


Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala 
    370                 375                 380                 


Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr 
385                 390                 395                 400 


Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu 
                405                 410                 415     


Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser 
            420                 425                 430         


Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser 
        435                 440                 445             


Leu Ser Pro Gly 
    450         


<210>  50
<211>  1359
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HC mAb12 nucleic acid sequence

<400>  50
caggtgcagc tggtgcagtc tggcgccgaa gtgaagaaac caggcgccag cgtgaaggtg       60

tcctgcaagg tgtccggcta catcctgagc aagctgagcg tgcactgggt gcgccaggcc      120

cctggaaaag gcctggaatg gatgggcggc agcgagcgcg aagatggcga gacagtgtac      180

gcccagaagt tccagggccg gatcagcctg accgaggaca cctctatcga gacagcctac      240

atggaactga gcagcctgtc cagcgaggat accgccgtgt actactgtgc caccggcggc      300

ttttggagca tgatcggcgg aaacgccgtg gactattggg gccagggaac cctcgtgacc      360

gtgtctagcg cctctacaaa gggccccagc gtgttccctc tggcccctag cagcaagagc      420

acatctggcg gaacagccgc cctgggctgc ctcgtgaagg actactttcc cgagcccgtg      480

acagtgtcct ggaacagcgg agccctgacc agcggagtgc atacctttcc agccgtgctg      540

cagagcagcg gcctgtactc tctgagcagc gtcgtgactg tgcccagcag cagcctggga      600

acccagacct acatctgcaa cgtgaaccac aagcccagca acaccaaggt ggacaagaag      660

gtggaaccca agagctgcga caagacccac acctgtcccc cttgtcctgc ccctgaactg      720

ctgggaggcc cttccgtgtt cctgttcccc ccaaagccca aggacaccct gatgatcagc      780

cggacccccg aagtgacctg cgtggtggtg gatgtgtccc acgaggaccc tgaagtgaag      840

ttcaattggt acgtggacgg ggtggaagtg cataacgcca agaccaagcc cagagaggaa      900

cagtacaaca gcacctaccg ggtggtgtcc gtgctgacag tgctgcacca ggactggctg      960

aacggcaaag agtacaagtg caaagtgtcc aacaaggccc tgcctgcccc catcgagaaa     1020

accatcagca aggccaaggg ccagccccgc gaaccccagg tgtacacact gcccccaagc     1080

agggacgagc tgaccaagaa ccaggtgtcc ctgacctgtc tcgtgaaagg cttctacccc     1140

tccgatatcg ccgtggaatg ggagagcaac ggccagcccg agaacaacta caagaccacc     1200

ccccctgtgc tggacagcga cggctcattc ttcctgtact ccaagctgac cgtggacaag     1260

tcccggtggc agcagggcaa cgtgttcagc tgcagcgtga tgcacgaggc cctgcacaac     1320

cactacaccc agaagtccct gagcctgagc cccggctga                            1359


<210>  51
<211>  452
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HC mAb13

<400>  51

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Val Ser Gly Tyr Ile Leu Ser Lys Leu 
            20                  25                  30          


Ser Val His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Gly Ser Glu Arg Glu Asp Gly Glu Thr Val Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Ile Ser Leu Thr Glu Asp Thr Ser Ile Glu Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Ser Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Thr Gly Gly Phe Trp Ser Met Ile Gly Gly Gln Gly Val Asp Tyr 
            100                 105                 110         


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly 
        115                 120                 125             


Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly 
    130                 135                 140                 


Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val 
145                 150                 155                 160 


Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe 
                165                 170                 175     


Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val 
            180                 185                 190         


Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val 
        195                 200                 205             


Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys 
    210                 215                 220                 


Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu 
225                 230                 235                 240 


Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr 
                245                 250                 255     


Leu Tyr Ile Thr Arg Glu Pro Glu Val Thr Cys Val Val Val Asp Val 
            260                 265                 270         


Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val 
        275                 280                 285             


Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser 
    290                 295                 300                 


Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu 
305                 310                 315                 320 


Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala 
                325                 330                 335     


Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro 
            340                 345                 350         


Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln 
        355                 360                 365             


Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala 
    370                 375                 380                 


Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr 
385                 390                 395                 400 


Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu 
                405                 410                 415     


Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser 
            420                 425                 430         


Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser 
        435                 440                 445             


Leu Ser Pro Gly 
    450         


<210>  52
<211>  1359
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HC mAb13 nucleic acid sequence

<400>  52
caggtgcagc tggtgcagtc tggcgccgaa gtgaagaaac caggcgccag cgtgaaggtg       60

tcctgcaagg tgtccggcta catcctgagc aagctgagcg tgcactgggt gcgccaggcc      120

cctggaaaag gcctggaatg gatgggcggc agcgagcgcg aagatggcga gacagtgtac      180

gcccagaagt tccagggccg gatcagcctg accgaggaca cctctatcga gacagcctac      240

atggaactga gcagcctgtc cagcgaggat accgccgtgt actactgtgc caccggcggc      300

ttttggagca tgatcggcgg acagggcgtg gactattggg gccagggaac cctcgtgacc      360

gtgtctagcg ccagcacaaa gggccccagc gtgttccctc tggcccctag cagcaagagc      420

acatctggcg gaacagccgc cctgggctgc ctcgtgaagg actactttcc cgagcccgtg      480

acagtgtcct ggaacagcgg agccctgacc agcggcgtgc acacatttcc agccgtgctg      540

cagagcagcg gcctgtactc tctgagcagc gtcgtgactg tgcccagcag cagcctggga      600

acccagacct acatctgcaa cgtgaaccac aagcccagca acaccaaggt ggacaagaag      660

gtggaaccca agagctgcga caagacccac acctgtcccc cttgtcctgc ccctgaactg      720

ctgggaggcc cttccgtgtt cctgttcccc ccaaagccca aggacaccct gtacatcacc      780

cgcgagcccg aagtgacctg cgtggtggtg gatgtgtccc acgaggaccc tgaagtgaag      840

ttcaattggt acgtggacgg ggtggaagtg cacaacgcca agaccaagcc cagagaggaa      900

cagtacaaca gcacctaccg ggtggtgtcc gtgctgacag tgctgcacca ggactggctg      960

aacggcaaag agtacaagtg caaagtgtcc aacaaggccc tgcctgcccc catcgagaaa     1020

accatcagca aggccaaggg ccagccccgc gaaccccagg tgtacacact gcccccaagc     1080

agggacgagc tgaccaagaa ccaggtgtcc ctgacctgtc tcgtgaaagg cttctacccc     1140

tccgatatcg ccgtggaatg ggagagcaac ggccagcccg agaacaacta caagaccacc     1200

ccccctgtgc tggacagcga cggctcattc ttcctgtact ccaagctgac cgtggacaag     1260

tcccggtggc agcagggcaa cgtgttcagc tgtagcgtga tgcacgaggc cctgcacaac     1320

cactacaccc agaagtccct gagcctgagc cccggctga                            1359


<210>  53
<211>  452
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HC mAb14

<400>  53

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Val Ser Gly Tyr Ile Leu Ser Lys Leu 
            20                  25                  30          


Ser Val His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Gly Ser Glu Arg Glu Asp Gly Glu Thr Val Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Ile Ser Leu Thr Glu Asp Thr Ser Ile Glu Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Ser Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Thr Gly Gly Phe Trp Ser Met Ile Gly Gly Gln Gly Val Asp Tyr 
            100                 105                 110         


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly 
        115                 120                 125             


Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly 
    130                 135                 140                 


Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val 
145                 150                 155                 160 


Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe 
                165                 170                 175     


Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val 
            180                 185                 190         


Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val 
        195                 200                 205             


Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys 
    210                 215                 220                 


Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu 
225                 230                 235                 240 


Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr 
                245                 250                 255     


Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val 
            260                 265                 270         


Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val 
        275                 280                 285             


Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser 
    290                 295                 300                 


Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu 
305                 310                 315                 320 


Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala 
                325                 330                 335     


Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro 
            340                 345                 350         


Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln 
        355                 360                 365             


Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala 
    370                 375                 380                 


Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr 
385                 390                 395                 400 


Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu 
                405                 410                 415     


Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser 
            420                 425                 430         


Val Leu His Glu Ala Leu His Ser His Tyr Thr Gln Lys Ser Leu Ser 
        435                 440                 445             


Leu Ser Pro Gly 
    450         


<210>  54
<211>  1359
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HC mAb14 nucleic acid sequence

<400>  54
caggtgcagc tggtgcagtc tggcgccgaa gtgaagaaac caggcgccag cgtgaaggtg       60

tcctgcaagg tgtccggcta catcctgagc aagctgagcg tgcactgggt gcgccaggcc      120

cctggaaaag gcctggaatg gatgggcggc agcgagcgcg aagatggcga gacagtgtac      180

gcccagaagt tccagggccg gatcagcctg accgaggaca cctctatcga gacagcctac      240

atggaactga gcagcctgtc cagcgaggat accgccgtgt actactgtgc caccggcggc      300

ttttggagca tgatcggcgg acagggcgtg gactattggg gccagggaac cctcgtgacc      360

gtgtctagcg ccagcacaaa gggccccagc gtgttccctc tggcccctag cagcaagagc      420

acatctggcg gaacagccgc cctgggctgc ctcgtgaagg actactttcc cgagcccgtg      480

acagtgtcct ggaacagcgg agccctgacc agcggcgtgc acacatttcc agccgtgctg      540

cagagcagcg gcctgtactc tctgagcagc gtcgtgactg tgcccagcag cagcctggga      600

acccagacct acatctgcaa cgtgaaccac aagcccagca acaccaaggt ggacaagaag      660

gtggaaccca agagctgcga caagacccac acctgtcccc cttgtcctgc ccctgaactg      720

ctgggaggcc cttccgtgtt cctgttcccc ccaaagccca aggacaccct gatgatcagc      780

cggacccccg aagtgacctg cgtggtggtg gatgtgtccc acgaggaccc tgaagtgaag      840

ttcaattggt acgtggacgg ggtggaagtg cacaacgcca agaccaagcc cagagaggaa      900

cagtacaaca gcacctaccg ggtggtgtcc gtgctgacag tgctgcacca ggactggctg      960

aacggcaaag agtacaagtg caaagtgtcc aacaaggccc tgcctgcccc catcgagaaa     1020

accatcagca aggccaaggg ccagccccgc gaaccccagg tgtacacact gcccccaagc     1080

agggacgagc tgaccaagaa ccaggtgtcc ctgacctgtc tcgtgaaagg cttctacccc     1140

tccgatatcg ccgtggaatg ggagagcaac ggccagcccg agaacaacta caagaccacc     1200

ccccctgtgc tggacagcga cggctcattc ttcctgtact ccaagctgac cgtggacaag     1260

tcccggtggc agcagggcaa cgtgttcagc tgtagcgtgc tgcacgaggc cctgcacagc     1320

cactacaccc agaagtccct gagcctgagc cccggctga                            1359


<210>  55
<211>  329
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IgG1 constant region

<400>  55

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys 
1               5                   10                  15      


Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 
65                  70                  75                  80  


Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys 
            100                 105                 110         


Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 
        115                 120                 125             


Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
    130                 135                 140                 


Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 
145                 150                 155                 160 


Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
                165                 170                 175     


Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
            180                 185                 190         


His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
        195                 200                 205             


Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
    210                 215                 220                 


Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu 
225                 230                 235                 240 


Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 
                245                 250                 255     


Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
            260                 265                 270         


Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
        275                 280                 285             


Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 
    290                 295                 300                 


Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
305                 310                 315                 320 


Gln Lys Ser Leu Ser Leu Ser Pro Gly 
                325                 


<210>  56
<211>  123
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH mAb10

<400>  56

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Val Ser Gly Tyr Ile Leu Ser Lys Leu 
            20                  25                  30          


Ser Val His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Gly Ser Glu Arg Glu Asp Gly Glu Thr Val Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Ile Ser Leu Thr Glu Asp Thr Ser Ile Glu Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Ser Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Thr Gly Gly Phe Trp Ser Ile Ile Gly Gly Asn Gly Val Asp Tyr 
            100                 105                 110         


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120             


<210>  57
<211>  123
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH mAb11

<400>  57

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Val Ser Gly Tyr Ile Leu Ser Lys Leu 
            20                  25                  30          


Ser Val His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Gly Ser Glu Arg Glu Asp Gly Glu Thr Val Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Ile Ser Leu Thr Glu Asp Thr Ser Ile Glu Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Ser Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Thr Gly Gly Phe Trp Ser Met Ile Gly Gly Gln Gly Val Asp Tyr 
            100                 105                 110         


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120             


<210>  58
<211>  123
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH mAb12

<400>  58

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Val Ser Gly Tyr Ile Leu Ser Lys Leu 
            20                  25                  30          


Ser Val His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Gly Ser Glu Arg Glu Asp Gly Glu Thr Val Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Ile Ser Leu Thr Glu Asp Thr Ser Ile Glu Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Ser Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Thr Gly Gly Phe Trp Ser Met Ile Gly Gly Asn Ala Val Asp Tyr 
            100                 105                 110         


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120             


<210>  59
<211>  221
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IgG1 FC region A

<400>  59

Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe 
1               5                   10                  15      


Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro 
            20                  25                  30          


Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val 
        35                  40                  45              


Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr 
    50                  55                  60                  


Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val 
65                  70                  75                  80  


Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys 
                85                  90                  95      


Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser 
            100                 105                 110         


Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro 
        115                 120                 125             


Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val 
    130                 135                 140                 


Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly 
145                 150                 155                 160 


Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp 
                165                 170                 175     


Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp 
            180                 185                 190         


Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His 
        195                 200                 205             


Ala His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
    210                 215                 220     


<210>  60
<211>  221
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IgG1 FC region AAA

<400>  60

Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe 
1               5                   10                  15      


Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro 
            20                  25                  30          


Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val 
        35                  40                  45              


Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr 
    50                  55                  60                  


Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val 
65                  70                  75                  80  


Leu Ala Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys 
                85                  90                  95      


Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser 
            100                 105                 110         


Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro 
        115                 120                 125             


Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val 
    130                 135                 140                 


Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Ala Trp Glu Ser Asn Gly 
145                 150                 155                 160 


Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp 
                165                 170                 175     


Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp 
            180                 185                 190         


Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His 
        195                 200                 205             


Ala His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
    210                 215                 220     


<210>  61
<211>  221
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IgG1 FC region QL

<400>  61

Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe 
1               5                   10                  15      


Leu Phe Pro Pro Lys Pro Lys Asp Gln Leu Met Ile Ser Arg Thr Pro 
            20                  25                  30          


Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val 
        35                  40                  45              


Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr 
    50                  55                  60                  


Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val 
65                  70                  75                  80  


Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys 
                85                  90                  95      


Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser 
            100                 105                 110         


Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro 
        115                 120                 125             


Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val 
    130                 135                 140                 


Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly 
145                 150                 155                 160 


Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp 
                165                 170                 175     


Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp 
            180                 185                 190         


Gln Gln Gly Asn Val Phe Ser Cys Ser Val Leu His Glu Ala Leu His 
        195                 200                 205             


Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
    210                 215                 220     


<210>  62
<211>  221
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IgG1 FC region YTE

<400>  62

Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe 
1               5                   10                  15      


Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Tyr Ile Thr Arg Glu Pro 
            20                  25                  30          


Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val 
        35                  40                  45              


Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr 
    50                  55                  60                  


Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val 
65                  70                  75                  80  


Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys 
                85                  90                  95      


Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser 
            100                 105                 110         


Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro 
        115                 120                 125             


Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val 
    130                 135                 140                 


Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly 
145                 150                 155                 160 


Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp 
                165                 170                 175     


Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp 
            180                 185                 190         


Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His 
        195                 200                 205             


Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
    210                 215                 220     


<210>  63
<211>  221
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IgG1 FC region LS

<400>  63

Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe 
1               5                   10                  15      


Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro 
            20                  25                  30          


Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val 
        35                  40                  45              


Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr 
    50                  55                  60                  


Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val 
65                  70                  75                  80  


Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys 
                85                  90                  95      


Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser 
            100                 105                 110         


Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro 
        115                 120                 125             


Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val 
    130                 135                 140                 


Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly 
145                 150                 155                 160 


Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp 
                165                 170                 175     


Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp 
            180                 185                 190         


Gln Gln Gly Asn Val Phe Ser Cys Ser Val Leu His Glu Ala Leu His 
        195                 200                 205             


Ser His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
    210                 215                 220     


