﻿                         序列表

<110>  中国科学院广州生物医药与健康研究院
 
<120>  高稳定性和高亲和力的DMIC及其制法

<130>  P2017-1883

<150>  201610918179.8
<151>  2016-10-20

<160>  32    

<170>  PatentIn version 3.5

<210>  1
<211>  181
<212>  PRT
<213>  人工序列(artificial sequence)

<400>  1

Met Glu Pro His Ser Leu Arg Tyr Asn Leu Thr Val Leu Ser Trp Asp 
1               5                   10                  15      


Gly Ser Val Gln Ser Gly Phe Leu Thr Glu Val His Leu Asp Gly Gln 
            20                  25                  30          


Pro Phe Leu Arg Cys Asp Arg Gln Lys Cys Arg Ala Lys Pro Gln Gly 
        35                  40                  45              


Gln Trp Ala Glu Asp Val Leu Gly Asn Lys Thr Trp Asp Arg Glu Thr 
    50                  55                  60                  


Arg Asp Leu Thr Gly Asn Gly Lys Asp Leu Arg Met Thr Leu Ala His 
65                  70                  75                  80  


Ile Lys Asp Gln Lys Glu Gly Leu His Ser Leu Gln Glu Ile Arg Val 
                85                  90                  95      


Cys Glu Ile His Glu Asp Asn Ser Thr Arg Ser Ser Gln His Phe Tyr 
            100                 105                 110         


Tyr Asp Gly Glu Leu Phe Leu Ser Gln Asn Leu Glu Thr Lys Glu Trp 
        115                 120                 125             


Thr Met Pro Gln Ser Ser Arg Ala Gln Thr Leu Ala Met Asn Val Arg 
    130                 135                 140                 


Asn Phe Leu Lys Glu Asp Ala Met Lys Thr Lys Thr His Tyr His Ala 
145                 150                 155                 160 


Met His Ala Asp Cys Leu Gln Glu Leu Arg Arg Tyr Leu Lys Ser Gly 
                165                 170                 175     


Val Val Leu Arg Arg 
            180     


<210>  2
<211>  543
<212>  DNA
<213>  人工序列(artificial sequence)

<400>  2
atggaaccgc atagcctgcg ttataatctg accgttctga gttgggatgg tagcgttcag       60

agcggttttc tgaccgaagt tcatctggat ggtcagccgt ttctgcgttg tgatcgtcag      120

aaatgtcgtg caaaaccgca gggtcagtgg gcagaagatg ttctgggtaa taaaacctgg      180

gatcgtgaaa cccgtgatct gaccggtaat ggtaaagatc tgcgtatgac cctggcccat      240

attaaagatc agaaagaagg tctgcacagc ctgcaagaaa ttcgtgtttg tgaaattcat      300

gaagataata gcacccgtag cagtcagcat ttctattatg atggtgaact gtttctgagc      360

cagaatctgg aaaccaaaga atggaccatg ccgcagagca gccgtgcaca gaccctggca      420

atgaatgttc gtaattttct gaaagaggac gccatgaaaa ccaaaaccca ttatcatgca      480

atgcatgcag attgtctgca agaactgcgt cgttatctga aaagcggtgt tgttctgcgt      540

cgt                                                                    543


<210>  3
<211>  181
<212>  PRT
<213>  人工序列(artificial sequence)

<400>  3

Met Glu Pro His Ser Leu Arg Tyr Asn Leu Thr Val Ser Ser Gln Asp 
1               5                   10                  15      


Gly Ser Val Gln Ser Gly Phe Gln Thr Glu Val His Leu Asp Gly Gln 
            20                  25                  30          


Pro Phe Leu Arg Cys Asp Arg Gln Lys Cys Arg Ala Lys Pro Gln Gly 
        35                  40                  45              


Gln Trp Gly Glu Asp Thr Leu Gly Asn Lys Thr Trp Asp Arg Glu Thr 
    50                  55                  60                  


Arg Asp Leu Thr Gly Asn Gly Lys Asp Leu Arg Met Thr Leu Ala His 
65                  70                  75                  80  


Ile Lys Asp Gln Lys Glu Gly Ser His Ser Leu Gln Glu Thr Arg Ser 
                85                  90                  95      


Cys Glu Ile His Glu Asp Asn Ser Thr Arg Ser Ser Gln His Phe Tyr 
            100                 105                 110         


Tyr Asp Gly Glu Leu Phe Leu Ser Gln Asn Leu Glu Thr Lys Glu Trp 
        115                 120                 125             


Thr Val Pro Gln Ser Ser Arg Ala Gln Thr Leu Ala Gln Asn Val Arg 
    130                 135                 140                 


Asn Phe Leu Lys Glu Asp Ala Met Lys Thr Lys Thr His Tyr His Ala 
145                 150                 155                 160 


Met His Ala Asp Cys Leu Gln Glu Leu Arg Arg Tyr Leu Lys Ser Gly 
                165                 170                 175     


Val Val Pro Arg Arg 
            180     


<210>  4
<211>  543
<212>  DNA
<213>  人工序列(artificial sequence)

<400>  4
atggaaccgc atagcctgcg ttataatctg accgttagca gtcaggatgg tagcgttcag       60

agcggttttc agaccgaagt tcatctggat ggtcagccgt ttctgcgttg tgatcgtcag      120

aaatgtcgtg caaaaccgca gggtcagtgg ggtgaagata ccctgggtaa taaaacctgg      180

gatcgtgaaa cccgtgatct gaccggtaat ggtaaagatc tgcgtatgac cctggcccat      240

attaaagatc agaaagaagg tagccacagc ctgcaagaaa cccgtagctg tgaaattcat      300

gaagataata gcacccgtag cagtcagcat ttctattatg atggtgaact gtttctgagc      360

cagaatctgg aaaccaaaga atggaccgtt ccgcagagca gccgtgcaca gaccctggca      420

cagaatgttc gtaattttct gaaagaggac gccatgaaaa ccaaaaccca ttatcatgca      480

atgcatgcag attgtctgca agaactgcgt cgttatctga aaagcggtgt tgttccgcgt      540

cgt                                                                    543


<210>  5
<211>  181
<212>  PRT
<213>  人工序列(artificial sequence)

<400>  5

Met Glu Pro His Ser Leu Arg Tyr Asn Leu Thr Val Ser Ser Gln Asp 
1               5                   10                  15      


Gly Ser Val Gln Ser Gly Phe Gln Thr Glu Val His Leu Asp Gly Gln 
            20                  25                  30          


Pro Phe Leu Arg Cys Asp Arg Gln Lys Cys Arg Ala Lys Pro Gln Gly 
        35                  40                  45              


Gln Trp Gly Glu Asp Thr Leu Gly Asn Lys Thr Trp Asp Arg Glu Thr 
    50                  55                  60                  


Arg Asp Leu Thr Gly Asn Gly Lys Asp Leu Arg Met Thr Leu Ala His 
65                  70                  75                  80  


Ile Lys Asp Gln Lys Glu Gly Ser His Ser Leu Gln Glu Thr Arg Ser 
                85                  90                  95      


Cys Glu Ile His Glu Asp Asn Ser Thr Arg Ser Ser Gln His Phe Tyr 
            100                 105                 110         


Tyr Asp Gly Glu Leu Phe Leu Ser Gln Asn Leu Glu Thr Lys Glu Trp 
        115                 120                 125             


Thr Val Pro Gln Ser Ser Arg Ala Gln Thr Leu Ala Gln Asn Val Arg 
    130                 135                 140                 


Asn Phe Leu Lys Glu Asp Ala Met Lys Thr Lys Thr His Tyr His Ala 
145                 150                 155                 160 


Met Arg Ala Asp Cys Leu Gln Glu Leu Arg Arg Tyr Leu Lys Ser Gly 
                165                 170                 175     


Val Ile Pro Arg Arg 
            180     


<210>  6
<211>  543
<212>  DNA
<213>  人工序列(artificial sequence)

<400>  6
atggaaccgc atagcctgcg ttataatctg accgttagca gtcaggatgg tagcgttcag       60

agcggttttc agaccgaagt tcatctggat ggtcagccgt ttctgcgttg tgatcgtcag      120

aaatgtcgtg caaaaccgca gggtcagtgg ggtgaagata ccctgggtaa taaaacctgg      180

gatcgtgaaa cccgtgatct gaccggtaat ggtaaagatc tgcgtatgac cctggcccat      240

attaaagatc agaaagaagg tagccacagc ctgcaagaaa cccgtagctg tgaaattcat      300

gaagataata gcacccgtag cagtcagcat ttctattatg atggtgaact gtttctgagc      360

cagaatctgg aaaccaaaga atggaccgtt ccgcagagca gccgtgcaca gaccctggca      420

cagaatgttc gtaattttct gaaagaggac gccatgaaaa ccaaaaccca ttatcatgca      480

atgcgtgcag attgtctgca agaactgcgt cgttatctga aaagcggtgt tattccgcgt      540

cgt                                                                    543


<210>  7
<211>  181
<212>  PRT
<213>  人工序列(artificial sequence)

<400>  7

Met Glu Pro His Ser Leu Arg Tyr Asn Leu Thr Val Ser Met Gln Asp 
1               5                   10                  15      


Gly Ser Val Gln Ser Gly Phe Gln Thr Glu Val His Leu Asp Gly Gln 
            20                  25                  30          


Pro Phe Leu Arg Cys Asp Arg Gln Lys Cys Arg Ala Lys Pro Gln Gly 
        35                  40                  45              


Gln Trp Gly Glu Asp Thr Leu Gly Asn Lys Thr Trp Asp Arg Glu Thr 
    50                  55                  60                  


Arg Asp Leu Thr Gly Asn Gly Lys Asp Leu Arg Met Thr Leu Ala His 
65                  70                  75                  80  


Ile Lys Asp Gln Lys Glu Gly Ser His Ser Leu Gln Glu Thr Arg Ser 
                85                  90                  95      


Cys Glu Ile His Glu Asp Asn Ser Thr Arg Ser Ser Ile His Phe Tyr 
            100                 105                 110         


Tyr Asp Gly Glu Leu Phe Leu Ser Gly Asn Leu Glu Thr Lys Glu Trp 
        115                 120                 125             


Thr Val Pro Gln Ser Ser Arg Ala Gln Thr Leu Ala Gln Asn Val Arg 
    130                 135                 140                 


Asn Phe Trp Lys Glu Asp Ala Met Lys Thr Lys Thr His Trp His Ala 
145                 150                 155                 160 


Met His Ala Asp Cys Leu Gln Glu Leu Arg Arg Tyr Leu Lys Ser Gly 
                165                 170                 175     


Val Val Pro Arg Arg 
            180     


<210>  8
<211>  543
<212>  DNA
<213>  人工序列(artificial sequence)

<400>  8
atggaaccgc atagcctgcg ttataatctg accgttagca tgcaggatgg tagcgttcag       60

agcggttttc agaccgaagt tcatctggat ggtcagccgt ttctgcgttg tgatcgtcag      120

aaatgtcgtg caaaaccgca gggtcagtgg ggtgaagata ccctgggtaa taaaacctgg      180

gatcgtgaaa cccgtgatct gaccggtaat ggtaaagatc tgcgtatgac cctggcccat      240

attaaagatc agaaagaagg tagccacagc ctgcaagaaa cccgtagctg tgaaattcat      300

gaagataata gcacccgtag cagtattcat ttctattatg atggtgaact gtttttgagc      360

ggtaatctgg aaaccaaaga atggaccgtt ccgcagagca gccgtgcaca gaccctggca      420

cagaatgttc gtaatttttg gaaagaggac gccatgaaaa ccaaaaccca ttggcatgca      480

atgcatgcag attgtctgca agaactgcgt cgttatctga aaagcggtgt tgttccgcgt      540

cgt                                                                    543


<210>  9
<211>  181
<212>  PRT
<213>  人工序列(artificial sequence)

<400>  9

Met Glu Pro His Ser Leu Arg Tyr Asn Leu Thr Val Ser Ile Gln Asp 
1               5                   10                  15      


Gly Ser Val Gln Ser Gly Phe Gln Thr Glu Val His Leu Asp Gly Gln 
            20                  25                  30          


Pro Phe Leu Arg Cys Asp Arg Gln Lys Cys Arg Ala Lys Pro Gln Gly 
        35                  40                  45              


Gln Trp Gly Glu Asp Thr Leu Gly Asn Lys Thr Trp Asp Arg Glu Thr 
    50                  55                  60                  


Arg Asp Leu Thr Gly Asn Gly Lys Asp Leu Arg Met Thr Leu Ala His 
65                  70                  75                  80  


Ile Lys Asp Gln Lys Glu Gly Ser His Ser Leu Gln Glu Thr Arg Ser 
                85                  90                  95      


Cys Glu Ile His Glu Asp Asn Ser Thr Arg Ser Ser Ile His Phe Tyr 
            100                 105                 110         


Tyr Asp Gly Glu Leu Phe Leu Ser Asn Asn Leu Glu Thr Lys Glu Trp 
        115                 120                 125             


Thr Val Pro Gln Ser Ser Arg Ala Gln Thr Leu Ala Gln Asn Val Arg 
    130                 135                 140                 


Asn Phe Trp Lys Glu Asp Ala Met Lys Thr Lys Thr His Trp His Ala 
145                 150                 155                 160 


Met His Ala Asp Cys Leu Gln Glu Leu Arg Arg Tyr Leu Lys Ser Gly 
                165                 170                 175     


Val Val Pro Arg Arg 
            180     


<210>  10
<211>  543
<212>  DNA
<213>  人工序列(artificial sequence)

<400>  10
atggaaccgc atagcctgcg ttataatctg accgttagca ttcaggatgg tagcgttcag       60

agcggttttc agaccgaagt tcatctggat ggtcagccgt ttctgcgttg tgatcgtcag      120

aaatgtcgtg caaaaccgca gggtcagtgg ggtgaagata ccctgggtaa taaaacctgg      180

gatcgtgaaa cccgtgatct gaccggtaat ggtaaagatc tgcgtatgac cctggcccat      240

attaaagatc agaaagaagg tagccacagc ctgcaagaaa cccgtagctg tgaaattcat      300

gaagataata gcacccgtag cagtattcat ttctattatg atggtgaact gtttttgagc      360

aataatctgg aaaccaaaga atggaccgtt ccgcagagca gccgtgcaca gaccctggca      420

cagaatgttc gtaatttttg gaaagaggac gccatgaaaa ccaaaaccca ttggcatgca      480

atgcatgcag attgtctgca agaactgcgt cgttatctga aaagcggtgt tgttccgcgt      540

cgt                                                                    543


<210>  11
<211>  181
<212>  PRT
<213>  人工序列(artificial sequence)

<400>  11

Met Glu Pro His Ser Leu Arg Tyr Asn Leu Thr Val Ser Ser Gln Asp 
1               5                   10                  15      


Gly Ser Val Gln Ser Gly Phe Gln Thr Glu Val His Leu Asp Gly Gln 
            20                  25                  30          


Pro Phe Leu Arg Cys Asp Arg Gln Lys Cys Arg Ala Lys Pro Gln Gly 
        35                  40                  45              


Gln Trp Gly Glu Asp Thr Leu Gly Asn Lys Thr Trp Asp Arg Glu Thr 
    50                  55                  60                  


Arg Asp Leu Thr Gly Asn Gly Lys Asp Leu Arg Met Thr Leu Ala His 
65                  70                  75                  80  


Ile Lys Asp Gln Lys Glu Gly Ser His Ser Leu Gln Glu Thr Arg Ser 
                85                  90                  95      


Cys Glu Ile His Glu Asp Asn Ser Thr Arg Ser Ser His His Phe Tyr 
            100                 105                 110         


Tyr Asp Gly Glu Leu Phe Leu Ser Trp Asn Leu Glu Thr Lys Glu Phe 
        115                 120                 125             


Thr Val Pro Gln Ser Ser Arg Ala Gln Thr Leu Ala Gln Asn Val Arg 
    130                 135                 140                 


Asn Phe Trp Lys Glu Asp Ala Met Lys Thr Lys Thr His Phe His Ala 
145                 150                 155                 160 


Met His Ala Asp Cys Leu Gln Glu Leu Arg Arg Tyr Leu Lys Ser Gly 
                165                 170                 175     


Val Val Pro Arg Arg 
            180     


<210>  12
<211>  543
<212>  DNA
<213>  人工序列(artificial sequence)

<400>  12
atggaaccgc atagcctgcg ttataatctg accgttagca gtcaggatgg tagcgttcag       60

agcggttttc agaccgaagt tcatctggat ggtcagccgt ttctgcgttg tgatcgtcag      120

aaatgtcgtg caaaaccgca gggtcagtgg ggtgaagata ccctgggtaa taaaacctgg      180

gatcgtgaaa cccgtgatct gaccggtaat ggtaaagatc tgcgtatgac cctggcccat      240

attaaagatc agaaagaagg tagccacagc ctgcaagaaa cccgtagctg tgaaattcat      300

gaagataata gcacccgtag cagtcatcat ttctattatg atggtgaact gtttttgagc      360

tggaatctgg aaaccaaaga atttaccgtt ccgcagagca gccgtgcaca gaccctggca      420

cagaatgttc gtaatttttg gaaagaggac gccatgaaaa ccaaaaccca ttttcatgca      480

atgcatgcag attgtctgca agaactgcgt cgttatctga aaagcggtgt tgttccgcgt      540

cgt                                                                    543


<210>  13
<211>  181
<212>  PRT
<213>  人工序列(artificial sequence)

<400>  13

Met Glu Pro His Ser Leu Arg Tyr Asp Phe Thr Val Ser Ser Gln Asp 
1               5                   10                  15      


Gly Ser Val Gln Ser Gly Phe Gln Thr Glu Val His Leu Asp Gly Gln 
            20                  25                  30          


Pro Phe Ile Arg Cys Asp Arg Gln Lys Cys Arg Ala Lys Pro Gln Gly 
        35                  40                  45              


Gln Trp Gly Glu Asp Thr Leu Gly Asn Lys Thr Trp Asp Arg Glu Thr 
    50                  55                  60                  


Arg Asp Leu Thr Gly Asn Gly Lys Asp Leu Arg Met Thr Leu Ala His 
65                  70                  75                  80  


Ile Lys Asp Gln Lys Glu Gly Ser His Ser Leu Gln Glu Thr Arg Ser 
                85                  90                  95      


Cys Glu Ile His Glu Asp Asn Ser Thr Arg Ser Ser His His Phe Tyr 
            100                 105                 110         


Tyr Asp Gly Glu Leu Phe Leu Ser Trp Asn Leu Glu Thr Lys Glu Phe 
        115                 120                 125             


Thr Val Pro Gln Ser Ser Arg Ala Gln Thr Leu Ala Gln Asn Val Arg 
    130                 135                 140                 


Asn Phe Trp Lys Glu Asp Ala Met Lys Thr Lys Thr His Phe His Ala 
145                 150                 155                 160 


Met Arg Ala Asp Cys Leu Gln Glu Leu Arg Arg Tyr Leu Lys Ser Gly 
                165                 170                 175     


Val Ile Pro Arg Arg 
            180     


<210>  14
<211>  543
<212>  DNA
<213>  人工序列(artificial sequence)

<400>  14
atggaaccgc actcgctgcg ttatgatttc accgtgtcct cccaagatgg ctcagtccag       60

tcgggcttcc agaccgaagt ccatctggat ggccagccgt ttattcgttg cgaccgccaa      120

aaatgtcgtg cgaaaccgca gggccaatgg ggtgaagata ccctgggtaa caaaacgtgg      180

gatcgtgaaa cccgcgacct gacgggcaat ggtaaagatc tgcgcatgac cctggcacat      240

attaaagacc agaaagaagg ctcacactcg ctgcaagaaa cccgtagctg cgaaatccac      300

gaagataact ctacgcgcag ctctcatcac ttttattacg acggtgaact gttcctgtcc      360

tggaatctgg aaaccaaaga attcacggtg ccgcagagtt cccgtgcaca gaccctggcc      420

caaaacgttc gcaatttttg gaaagaagat gcaatgaaaa ccaaaacgca tttccacgct      480

atgcgtgccg attgtctgca agaactgcgt cgttacctga aaagtggtgt tattccgcgt      540

cgc                                                                    543


<210>  15
<211>  181
<212>  PRT
<213>  人工序列(artificial sequence)

<400>  15

Met Glu Pro His Ser Leu Arg Tyr Asp Phe Thr Val Ser Ser Gln Asp 
1               5                   10                  15      


Gly Ser Val Gln Ser Gly Phe Gln Thr Glu Val His Leu Asp Gly Gln 
            20                  25                  30          


Pro Phe Ile Arg Cys Asp Arg Gln Lys Cys Arg Ala Lys Pro Gln Gly 
        35                  40                  45              


Gln Trp Gly Glu Asp Thr Leu Gly Asn Lys Thr Trp Asp Arg Glu Thr 
    50                  55                  60                  


Arg Asp Leu Thr Gly Asn Gly Lys Asp Leu Arg Met Thr Leu Ala His 
65                  70                  75                  80  


Ile Lys Asp Gln Lys Glu Gly Ser His Ser Leu Gln Glu Thr Arg Ser 
                85                  90                  95      


Cys Glu Ile His Glu Asp Asn Ser Thr Arg Ser Ser Gln His Phe Tyr 
            100                 105                 110         


Tyr Asp Gly Glu Leu Phe Leu Ser Gln Asn Leu Glu Thr Lys Glu Phe 
        115                 120                 125             


Thr Val Pro Gln Ser Ser Arg Ala Gln Thr Leu Ala Gln Asn Val Arg 
    130                 135                 140                 


Asn Phe Trp Lys Glu Asp Ala Met Lys Thr Lys Thr His Phe His Ala 
145                 150                 155                 160 


Met Arg Ala Asp Cys Leu Gln Glu Leu Arg Arg Tyr Leu Lys Ser Gly 
                165                 170                 175     


Val Ile Pro Arg Arg 
            180     


<210>  16
<211>  543
<212>  DNA
<213>  人工序列(artificial sequence)

<400>  16
atggaaccgc acagtctgcg ttatgatttt accgtttcct cacaagatgg ctcagtccaa       60

agtggcttcc agaccgaagt ccatctggat ggccagccgt ttattcgttg cgaccgccaa      120

aaatgtcgtg cgaaaccgca gggccaatgg ggtgaagata ccctgggtaa caaaacgtgg      180

gatcgtgaaa cccgcgacct gacgggcaat ggtaaagatc tgcgcatgac cctggcacat      240

attaaagacc agaaagaagg ctcacactcg ctgcaagaaa cccgtagctg cgaaatccat      300

gaagataact ctacgcgcag ctctcagcac ttttattacg acggtgaact gttcctgtcc      360

cagaatctgg aaaccaaaga attcacggtg ccgcagagtt cccgtgcaca gaccctggcc      420

caaaacgttc gcaatttttg gaaagaagat gcaatgaaaa ccaaaacgca tttccacgct      480

atgcgtgccg attgtctgca agaactgcgt cgctacctga aatctggtgt tattccgcgt      540

cgt                                                                    543


<210>  17
<211>  181
<212>  PRT
<213>  人工序列(artificial sequence)

<400>  17

Met Glu Pro His Ser Leu Arg Tyr Asp Phe Thr Val Ser Met Gln Asp 
1               5                   10                  15      


Gly Ser Val Gln Ser Gly Phe Gln Ala Glu Val His Leu Asp Gly Gln 
            20                  25                  30          


Pro Phe Ile Arg Cys Asp Arg Gln Lys Cys Arg Ala Lys Pro Gln Gly 
        35                  40                  45              


Asp Trp Glu Asn Asp Gln Leu Gly Asn Lys Thr Trp Asp Arg Glu Thr 
    50                  55                  60                  


Arg Asp Leu Thr Gly Asn Gly Lys Asp Leu Arg Met Thr Leu Ala His 
65                  70                  75                  80  


Ile Lys Asp Gln Lys Glu Gly Ser His Ser Leu Gln Glu Thr Arg Ser 
                85                  90                  95      


Cys Glu Ile His Glu Asp Asn Ser Thr Arg Ser Ser Ile His Phe Tyr 
            100                 105                 110         


Tyr Asp Gly Glu Leu Phe Leu Ser Met Asn Leu Glu Thr Lys Glu Trp 
        115                 120                 125             


Thr Val Pro Gln Ser Ser Arg Ala Gln Thr Leu Ala Gln Asn Val Arg 
    130                 135                 140                 


Asn Phe Trp Lys Glu Asp Ala Met Lys Thr Lys Thr His Trp His Ala 
145                 150                 155                 160 


Met Arg Ala Asp Cys Leu Gln Glu Leu Arg Arg Tyr Leu Lys Ser Gly 
                165                 170                 175     


Val Met Pro Arg Arg 
            180     


<210>  18
<211>  543
<212>  DNA
<213>  人工序列(artificial sequence)

<400>  18
atggaaccgc actcgctgcg ttatgatttt accgtttcaa tgcaagatgg ctcagttcag       60

tcgggcttcc aagcggaagt ccatctggat ggccagccgt ttattcgttg cgaccgccag      120

aaatgtcgtg ccaaaccgca aggcgattgg gaaaacgacc agctgggtaa taaaacctgg      180

gatcgtgaaa cccgcgacct gacgggcaac ggtaaagacc tgcgcatgac gctggcacat      240

atcaaagacc aaaaagaagg ctcacactcg ctgcaagaaa cccgtagctg cgaaattcat      300

gaagataact ctacgcgcag ctctatccac ttttattacg acggtgaact gttcctgtcc      360

atgaatctgg aaaccaaaga atggacggtg ccgcaaagtt cccgtgcaca gaccctggct      420

caaaacgttc gcaatttctg gaaagaagat gccatgaaaa ccaaaacgca ttggcacgcg      480

atgcgtgccg attgtctgca agaactgcgt cgctatctga aaagcggtgt tatgccgcgt      540

cgc                                                                    543


<210>  19
<211>  181
<212>  PRT
<213>  人工序列(artificial sequence)

<400>  19

Met Glu Pro His Ser Leu Arg Tyr Asp Phe Thr Val Ser Ile Gln Asp 
1               5                   10                  15      


Gly Ser Val Gln Ser Gly Phe Gln Ala Glu Val His Leu Asp Gly Gln 
            20                  25                  30          


Pro Phe Ile Arg Cys Asp Arg Gln Lys Cys Arg Ala Lys Pro Gln Gly 
        35                  40                  45              


Asp Trp Glu Asn Asp Gln Leu Gly Asn Lys Thr Trp Asp Arg Glu Thr 
    50                  55                  60                  


Arg Asp Leu Thr Gly Asn Gly Lys Asp Leu Arg Met Thr Leu Ala His 
65                  70                  75                  80  


Ile Lys Asp Gln Lys Glu Gly Ser His Ser Leu Gln Glu Thr Arg Ser 
                85                  90                  95      


Cys Glu Ile His Glu Asp Asn Ser Thr Arg Ser Ser Ile His Phe Tyr 
            100                 105                 110         


Tyr Asp Gly Glu Leu Phe Leu Ser Met Asn Leu Glu Thr Lys Glu Trp 
        115                 120                 125             


Thr Val Pro Gln Ser Ser Arg Ala Gln Thr Leu Ala Gln Asn Val Arg 
    130                 135                 140                 


Asn Phe Trp Lys Glu Asp Ala Met Lys Thr Lys Thr His Trp His Ala 
145                 150                 155                 160 


Met Arg Ala Asp Cys Leu Gln Glu Leu Arg Arg Tyr Leu Lys Ser Gly 
                165                 170                 175     


Val Met Pro Arg Arg 
            180     


<210>  20
<211>  543
<212>  DNA
<213>  人工序列(artificial sequence)

<400>  20
atggaaccgc actcgctgcg ttatgatttt accgtttcaa tccaagatgg ctcagttcag       60

tcgggcttcc aagcggaagt ccatctggat ggccagccgt ttattcgttg cgaccgccag      120

aaatgtcgtg ccaaaccgca aggcgattgg gaaaacgacc agctgggtaa taaaacctgg      180

gatcgtgaaa cccgcgacct gacgggcaac ggtaaagacc tgcgcatgac gctggcacat      240

atcaaagacc aaaaagaagg ctcacactcg ctgcaagaaa cccgtagctg cgaaattcat      300

gaagataact ctacgcgcag ctctatccac ttttattacg acggtgaact gttcctgtcc      360

atgaatctgg aaaccaaaga atggacggtg ccgcaaagtt cccgtgcaca gaccctggct      420

caaaacgttc gcaatttctg gaaagaagat gccatgaaaa ccaaaacgca ttggcacgcg      480

atgcgtgccg attgtctgca agaactgcgt cgctatctga aaagcggtgt tatgccgcgt      540

cgc                                                                    543


<210>  21
<211>  181
<212>  PRT
<213>  人工序列(artificial sequence)

<400>  21

Met Glu Pro His Ser Leu Arg Tyr Asn Leu Thr Val Ser Met Gln Asn 
1               5                   10                  15      


Gly Ser Val Gln Ser Gly Phe Gln Thr Glu Val His Leu Asp Gly Gln 
            20                  25                  30          


Pro Phe Leu Arg Cys Asp Thr Gln Lys Cys Arg Ala Lys Pro Gln Gly 
        35                  40                  45              


Gln Trp Gly Glu Asp Thr Leu Gly Asn Lys Thr Trp Asp Arg Glu Thr 
    50                  55                  60                  


Arg Asp Leu Thr Gly Trp Gly Lys Asp Leu Arg Met Thr Leu Ala His 
65                  70                  75                  80  


Ile Lys Asp Gln Lys Glu Gly Ser His Ser Leu Gln Glu Thr Arg Ser 
                85                  90                  95      


Cys Glu Ile His Glu Asp Asn Ser Thr Arg Ser Ser Ile His Phe Tyr 
            100                 105                 110         


Tyr Asp Gly Glu Leu Phe Leu Ser Gly Asn Leu Glu Thr Lys Glu Trp 
        115                 120                 125             


Thr Val Pro Gln Ser Ser Arg Ala Gln Thr Leu Ala Gln Asn Val Arg 
    130                 135                 140                 


Asn Phe Trp Lys Glu Val Ala Met Glu Thr Asp Thr His Trp Asp Ala 
145                 150                 155                 160 


Met His Ala Asp Cys Leu Gln Glu Leu Arg Arg Tyr Leu Lys Ser Gly 
                165                 170                 175     


Val Val Pro Arg Arg 
            180     


<210>  22
<211>  543
<212>  DNA
<213>  人工序列(artificial sequence)

<400>  22
atggaaccgc actcactgcg ttacaacctg accgtgtcga tgcaaaatgg tagcgtccaa       60

tcgggcttcc aaaccgaagt ccatctggat ggccagccgt ttctgcgttg cgacacgcaa      120

aaatgtcgcg cgaaaccgca gggccaatgg ggtgaagata ccctgggtaa caaaacgtgg      180

gatcgtgaaa cccgcgacct gacgggctgg ggtaaagatc tgcgtatgac cctggcacat      240

attaaagacc agaaagaagg ctcacactcg ctgcaagaaa cccgtagctg cgaaatccat      300

gaagataact ctacgcgcag ctctatccac ttttattacg acggtgaact gttcctgtcc      360

ggtaatctgg aaaccaaaga atggacggtt ccgcagagtt cccgtgccca gaccctggca      420

caaaacgtgc gcaatttctg gaaagaagtt gcaatggaaa ccgatacgca ctgggacgct      480

atgcatgctg actgcctgca agaactgcgt cgttacctga aaagtggtgt tgtgccgcgt      540

cgc                                                                    543


<210>  23
<211>  181
<212>  PRT
<213>  人工序列(artificial sequence)

<400>  23

Met Glu Pro His Ser Leu Arg Tyr Asn Leu Thr Val Ser Ile Gln Asn 
1               5                   10                  15      


Gly Ser Val Gln Ser Gly Phe Gln Thr Glu Val His Leu Asp Gly Gln 
            20                  25                  30          


Pro Phe Leu Arg Cys Asp Thr Gln Lys Cys Arg Ala Lys Pro Gln Gly 
        35                  40                  45              


Gln Trp Gly Glu Asp Thr Leu Gly Asn Lys Thr Trp Asp Arg Glu Thr 
    50                  55                  60                  


Arg Asp Leu Thr Gly Trp Gly Lys Asp Leu Arg Met Thr Leu Ala His 
65                  70                  75                  80  


Ile Lys Asp Gln Lys Glu Gly Ser His Ser Leu Gln Glu Thr Arg Ser 
                85                  90                  95      


Cys Glu Ile His Glu Asp Asn Ser Thr Arg Ser Ser Ile His Phe Tyr 
            100                 105                 110         


Tyr Asp Gly Glu Leu Phe Leu Ser Asn Asn Leu Glu Thr Lys Glu Trp 
        115                 120                 125             


Thr Val Pro Gln Ser Ser Arg Ala Gln Thr Leu Ala Gln Asn Val Arg 
    130                 135                 140                 


Asn Phe Trp Lys Glu Val Ala Met Glu Thr Asp Thr His Trp Asp Ala 
145                 150                 155                 160 


Met His Ala Asp Cys Leu Gln Glu Leu Arg Arg Tyr Leu Lys Ser Gly 
                165                 170                 175     


Val Val Pro Arg Arg 
            180     


<210>  24
<211>  543
<212>  DNA
<213>  人工序列(artificial sequence)

<400>  24
atggaaccgc actcactgcg ttacaacctg accgtgtcga tccaaaatgg tagcgtccaa       60

tcgggcttcc aaaccgaagt ccatctggat ggccagccgt ttctgcgttg cgacacgcaa      120

aaatgtcgcg cgaaaccgca gggccaatgg ggtgaagata ccctgggtaa caaaacgtgg      180

gatcgtgaaa cccgcgacct gacgggctgg ggtaaagatc tgcgtatgac cctggcacat      240

attaaagacc agaaagaagg ctcacactcg ctgcaagaaa cccgtagctg cgaaatccat      300

gaagataact ctacgcgcag ctctatccac ttttattacg acggtgaact gttcctgtcc      360

aacaatctgg aaaccaaaga atggacggtt ccgcagagtt cccgtgccca gaccctggca      420

caaaacgtgc gcaatttctg gaaagaagtt gcaatggaaa ccgatacgca ctgggacgct      480

atgcatgctg actgcctgca agaactgcgt cgttacctga aaagtggtgt tgtgccgcgt      540

cgc                                                                    543


<210>  25
<211>  181
<212>  PRT
<213>  人工序列(artificial sequence)

<400>  25

Met Glu Pro His Ser Leu Arg Tyr Asn Leu Thr Val Ser Ser Gln Asn 
1               5                   10                  15      


Gly Ser Val Gln Ser Gly Phe Gln Thr Glu Val His Leu Asp Gly Gln 
            20                  25                  30          


Pro Phe Leu Arg Cys Asp Thr Gln Lys Cys Arg Ala Lys Pro Gln Gly 
        35                  40                  45              


Gln Trp Gly Glu Asp Thr Leu Gly Asn Lys Thr Trp Asp Arg Glu Thr 
    50                  55                  60                  


Arg Asp Leu Thr Gly Trp Gly Lys Asp Leu Arg Met Thr Leu Ala His 
65                  70                  75                  80  


Ile Lys Asp Gln Lys Glu Gly Ser His Ser Leu Gln Glu Thr Arg Ser 
                85                  90                  95      


Cys Glu Ile His Glu Asp Asn Ser Thr Arg Ser Ser His His Phe Tyr 
            100                 105                 110         


Tyr Asp Gly Glu Leu Phe Leu Ser Trp Asn Leu Glu Thr Lys Glu Phe 
        115                 120                 125             


Thr Val Pro Gln Ser Ser Arg Ala Gln Thr Leu Ala Gln Asn Val Arg 
    130                 135                 140                 


Asn Phe Trp Lys Glu Val Ala Met Glu Thr Asp Thr His Phe Asp Ala 
145                 150                 155                 160 


Met His Ala Asp Cys Leu Gln Glu Leu Arg Arg Tyr Leu Lys Ser Gly 
                165                 170                 175     


Val Val Pro Arg Arg 
            180     


<210>  26
<211>  543
<212>  DNA
<213>  人工序列(artificial sequence)

<400>  26
atggaaccgc atagcctgcg ttataatctg accgttagca gtcagaatgg tagcgttcag       60

agcggttttc agaccgaagt tcatctggat ggtcagccgt ttctgcgttg tgatactcag      120

aaatgtcgtg caaaaccgca gggtcagtgg ggtgaagata ccctgggtaa taaaacctgg      180

gatcgtgaaa cccgtgatct gaccggttgg ggtaaagatc tgcgtatgac cctggcccat      240

attaaagatc agaaagaagg tagccacagc ctgcaagaaa cccgtagctg tgaaattcat      300

gaagataata gcacccgtag cagtcatcat ttctattatg atggtgaact gtttttgagc      360

tggaatctgg aaaccaaaga atttaccgtt ccgcagagca gccgtgcaca gaccctggca      420

cagaatgttc gtaatttttg gaaagaggtc gccatggaaa ccgacaccca ttttgatgca      480

atgcatgcag attgtctgca agaactgcgt cgttatctga aaagcggtgt tgttccgcgt      540

cgt                                                                    543


<210>  27
<211>  181
<212>  PRT
<213>  人工序列(artificial sequence)

<400>  27

Met Glu Pro His Ser Leu Arg Tyr Asp Phe Thr Val Ser Ser Gln Asn 
1               5                   10                  15      


Gly Ser Val Gln Ser Gly Phe Gln Thr Glu Val His Leu Asp Gly Gln 
            20                  25                  30          


Pro Phe Ile Arg Cys Asp Thr Gln Lys Cys Arg Ala Lys Pro Gln Gly 
        35                  40                  45              


Gln Trp Gly Glu Asp Thr Leu Gly Asn Lys Thr Trp Asp Arg Glu Thr 
    50                  55                  60                  


Arg Asp Leu Thr Gly Trp Gly Lys Asp Leu Arg Met Thr Leu Ala His 
65                  70                  75                  80  


Ile Lys Asp Gln Lys Glu Gly Ser His Ser Leu Gln Glu Thr Arg Ser 
                85                  90                  95      


Cys Glu Ile His Glu Asp Asn Ser Thr Arg Ser Ser Gln His Phe Tyr 
            100                 105                 110         


Tyr Asp Gly Glu Leu Phe Leu Ser Gln Asn Leu Glu Thr Lys Glu Phe 
        115                 120                 125             


Thr Val Pro Gln Ser Ser Arg Ala Gln Thr Leu Ala Gln Asn Val Arg 
    130                 135                 140                 


Asn Phe Trp Lys Glu Val Ala Met Glu Thr Asp Thr His Phe Asp Ala 
145                 150                 155                 160 


Met Arg Ala Asp Cys Leu Gln Glu Leu Arg Arg Tyr Leu Lys Ser Gly 
                165                 170                 175     


Val Ile Pro Arg Arg 
            180     


<210>  28
<211>  543
<212>  DNA
<213>  人工序列(artificial sequence)

<400>  28
atggaaccgc acagtctgcg ttatgatttt accgtttcct cacaaaatgg ctcagtccaa       60

agtggcttcc agaccgaagt ccatctggat ggccagccgt ttattcgttg cgacacccaa      120

aaatgtcgtg cgaaaccgca gggccaatgg ggtgaagata ccctgggtaa caaaacgtgg      180

gatcgtgaaa cccgcgacct gacgggctgg ggtaaagatc tgcgcatgac cctggcacat      240

attaaagacc agaaagaagg ctcacactcg ctgcaagaaa cccgtagctg cgaaatccat      300

gaagataact ctacgcgcag ctctcagcac ttttattacg acggtgaact gttcctgtcc      360

cagaatctgg aaaccaaaga attcacggtg ccgcagagtt cccgtgcaca gaccctggcc      420

caaaacgttc gcaatttttg gaaagaagtt gcaatggaaa ccgacacgca tttcgacgct      480

atgcgtgccg attgtctgca agaactgcgt cgctacctga aatctggtgt tattccgcgt      540

cgt                                                                    543


<210>  29
<211>  181
<212>  PRT
<213>  人工序列(artificial sequence)

<400>  29

Met Glu Pro His Ser Leu Arg Tyr Asp Phe Thr Val Ser Met Gln Asn 
1               5                   10                  15      


Gly Ser Val Gln Ser Gly Phe Gln Ala Glu Val His Leu Asp Gly Gln 
            20                  25                  30          


Pro Phe Ile Arg Cys Asp Thr Gln Lys Cys Arg Ala Lys Pro Gln Gly 
        35                  40                  45              


Asp Trp Glu Asn Asp Gln Leu Gly Asn Lys Thr Trp Asp Arg Glu Thr 
    50                  55                  60                  


Arg Asp Leu Thr Gly Trp Gly Lys Asp Leu Arg Met Thr Leu Ala His 
65                  70                  75                  80  


Ile Lys Asp Gln Lys Glu Gly Ser His Ser Leu Gln Glu Thr Arg Ser 
                85                  90                  95      


Cys Glu Ile His Glu Asp Asn Ser Thr Arg Ser Ser Ile His Phe Tyr 
            100                 105                 110         


Tyr Asp Gly Glu Leu Phe Leu Ser Met Asn Leu Glu Thr Lys Glu Trp 
        115                 120                 125             


Thr Val Pro Gln Ser Ser Arg Ala Gln Thr Leu Ala Gln Asn Val Arg 
    130                 135                 140                 


Asn Phe Trp Lys Glu Val Ala Met Glu Thr Asp Thr His Trp Asp Ala 
145                 150                 155                 160 


Met Arg Ala Asp Cys Leu Gln Glu Leu Arg Arg Tyr Leu Lys Ser Gly 
                165                 170                 175     


Val Met Pro Arg Arg 
            180     


<210>  30
<211>  543
<212>  DNA
<213>  人工序列(artificial sequence)

<400>  30
atggaaccgc actcgctgcg ttatgatttt accgtttcaa tgcaaaatgg ctcagttcag       60

tcgggcttcc aagcggaagt ccatctggat ggccagccgt ttattcgttg cgacacccag      120

aaatgtcgtg ccaaaccgca aggcgattgg gaaaacgacc agctgggtaa taaaacctgg      180

gatcgtgaaa cccgcgacct gacgggctgg ggtaaagacc tgcgcatgac gctggcacat      240

atcaaagacc aaaaagaagg ctcacactcg ctgcaagaaa cccgtagctg cgaaattcat      300

gaagataact ctacgcgcag ctctatccac ttttattacg acggtgaact gttcctgtcc      360

atgaatctgg aaaccaaaga atggacggtg ccgcaaagtt cccgtgcaca gaccctggct      420

caaaacgttc gcaatttctg gaaagaagtt gccatggaaa ccgacacgca ttgggacgcg      480

atgcgtgccg attgtctgca agaactgcgt cgctatctga aaagcggtgt tatgccgcgt      540

cgc                                                                    543


<210>  31
<211>  181
<212>  PRT
<213>  人工序列(artificial sequence)

<400>  31

Met Glu Pro His Ser Leu Arg Tyr Asp Phe Thr Val Ser Ile Gln Asn 
1               5                   10                  15      


Gly Ser Val Gln Ser Gly Phe Gln Ala Glu Val His Leu Asp Gly Gln 
            20                  25                  30          


Pro Phe Ile Arg Cys Asp Thr Gln Lys Cys Arg Ala Lys Pro Gln Gly 
        35                  40                  45              


Asp Trp Glu Asn Asp Gln Leu Gly Asn Lys Thr Trp Asp Arg Glu Thr 
    50                  55                  60                  


Arg Asp Leu Thr Gly Trp Gly Lys Asp Leu Arg Met Thr Leu Ala His 
65                  70                  75                  80  


Ile Lys Asp Gln Lys Glu Gly Ser His Ser Leu Gln Glu Thr Arg Ser 
                85                  90                  95      


Cys Glu Ile His Glu Asp Asn Ser Thr Arg Ser Ser Ile His Phe Tyr 
            100                 105                 110         


Tyr Asp Gly Glu Leu Phe Leu Ser Met Asn Leu Glu Thr Lys Glu Trp 
        115                 120                 125             


Thr Val Pro Gln Ser Ser Arg Ala Gln Thr Leu Ala Gln Asn Val Arg 
    130                 135                 140                 


Asn Phe Trp Lys Glu Val Ala Met Glu Thr Asp Thr His Trp Asp Ala 
145                 150                 155                 160 


Met Arg Ala Asp Cys Leu Gln Glu Leu Arg Arg Tyr Leu Lys Ser Gly 
                165                 170                 175     


Val Met Pro Arg Arg 
            180     


<210>  32
<211>  543
<212>  DNA
<213>  人工序列(artificial sequence)

<400>  32
atggaaccgc actcgctgcg ttatgatttt accgtttcaa tccaaaatgg ctcagttcag       60

tcgggcttcc aagcggaagt ccatctggat ggccagccgt ttattcgttg cgacacccag      120

aaatgtcgtg ccaaaccgca aggcgattgg gaaaacgacc agctgggtaa taaaacctgg      180

gatcgtgaaa cccgcgacct gacgggctgg ggtaaagacc tgcgcatgac gctggcacat      240

atcaaagacc aaaaagaagg ctcacactcg ctgcaagaaa cccgtagctg cgaaattcat      300

gaagataact ctacgcgcag ctctatccac ttttattacg acggtgaact gttcctgtcc      360

atgaatctgg aaaccaaaga atggacggtg ccgcaaagtt cccgtgcaca gaccctggct      420

caaaacgttc gcaatttctg gaaagaagtt gccatggaaa ccgacacgca ttgggacgcg      480

atgcgtgccg attgtctgca agaactgcgt cgctatctga aaagcggtgt tatgccgcgt      540

cgc                                                                    543


