                         SEQUENCE LISTING

<110>  bluebird bio, Inc.
       Jarjour, Jordan
       Pogson, Mark
 
<120>  TCRalpha HOMING ENDONUCLEASE VARIANTS

<130>  BLBD-075/00US

<140>  PCT/US2017/056178
<141>  2017-10-11

<150>  US 62/406,689
<151>  2016-10-11

<150>  US 62/414,266
<151>  2016-10-28

<160>  69    

<170>  PatentIn version 3.5

<210>  1
<211>  303
<212>  PRT
<213>  Ophiostoma novo-ulmi

<400>  1

Met Ala Tyr Met Ser Arg Arg Glu Ser Ile Asn Pro Trp Ile Leu Thr 
1               5                   10                  15      


Gly Phe Ala Asp Ala Glu Gly Ser Phe Leu Leu Arg Ile Arg Asn Asn 
            20                  25                  30          


Asn Lys Ser Ser Val Gly Tyr Ser Thr Glu Leu Gly Phe Gln Ile Thr 
        35                  40                  45              


Leu His Asn Lys Asp Lys Ser Ile Leu Glu Asn Ile Gln Ser Thr Trp 
    50                  55                  60                  


Lys Val Gly Val Ile Ala Asn Ser Gly Asp Asn Ala Val Ser Leu Lys 
65                  70                  75                  80  


Val Thr Arg Phe Glu Asp Leu Lys Val Ile Ile Asp His Phe Glu Lys 
                85                  90                  95      


Tyr Pro Leu Ile Thr Gln Lys Leu Gly Asp Tyr Met Leu Phe Lys Gln 
            100                 105                 110         


Ala Phe Cys Val Met Glu Asn Lys Glu His Leu Lys Ile Asn Gly Ile 
        115                 120                 125             


Lys Glu Leu Val Arg Ile Lys Ala Lys Leu Asn Trp Gly Leu Thr Asp 
    130                 135                 140                 


Glu Leu Lys Lys Ala Phe Pro Glu Ile Ile Ser Lys Glu Arg Ser Leu 
145                 150                 155                 160 


Ile Asn Lys Asn Ile Pro Asn Phe Lys Trp Leu Ala Gly Phe Thr Ser 
                165                 170                 175     


Gly Glu Gly Cys Phe Phe Val Asn Leu Ile Lys Ser Lys Ser Lys Leu 
            180                 185                 190         


Gly Val Gln Val Gln Leu Val Phe Ser Ile Thr Gln His Ile Lys Asp 
        195                 200                 205             


Lys Asn Leu Met Asn Ser Leu Ile Thr Tyr Leu Gly Cys Gly Tyr Ile 
    210                 215                 220                 


Lys Glu Lys Asn Lys Ser Glu Phe Ser Trp Leu Asp Phe Val Val Thr 
225                 230                 235                 240 


Lys Phe Ser Asp Ile Asn Asp Lys Ile Ile Pro Val Phe Gln Glu Asn 
                245                 250                 255     


Thr Leu Ile Gly Val Lys Leu Glu Asp Phe Glu Asp Trp Cys Lys Val 
            260                 265                 270         


Ala Lys Leu Ile Glu Glu Lys Lys His Leu Thr Glu Ser Gly Leu Asp 
        275                 280                 285             


Glu Ile Lys Lys Ile Lys Leu Asn Met Asn Lys Gly Arg Val Phe 
    290                 295                 300             


<210>  2
<211>  303
<212>  PRT
<213>  Ophiostoma novo-ulmi 

<400>  2

Met Ala Tyr Met Ser Arg Arg Glu Ser Ile Asn Pro Trp Ile Leu Thr 
1               5                   10                  15      


Gly Phe Ala Asp Ala Glu Gly Ser Phe Leu Leu Arg Ile Arg Asn Asn 
            20                  25                  30          


Asn Lys Ser Ser Val Gly Tyr Ser Thr Glu Leu Gly Phe Gln Ile Thr 
        35                  40                  45              


Leu His Asn Lys Asp Lys Ser Ile Leu Glu Asn Ile Gln Ser Thr Trp 
    50                  55                  60                  


Lys Val Gly Val Ile Ala Asn Ser Gly Asp Asn Ala Val Ser Leu Lys 
65                  70                  75                  80  


Val Thr Arg Phe Glu Asp Leu Lys Val Ile Ile Asp His Phe Glu Lys 
                85                  90                  95      


Tyr Pro Leu Ile Thr Gln Lys Leu Gly Asp Tyr Lys Leu Phe Lys Gln 
            100                 105                 110         


Ala Phe Ser Val Met Glu Asn Lys Glu His Leu Lys Glu Asn Gly Ile 
        115                 120                 125             


Lys Glu Leu Val Arg Ile Lys Ala Lys Leu Asn Trp Gly Leu Thr Asp 
    130                 135                 140                 


Glu Leu Lys Lys Ala Phe Pro Glu Asn Ile Ser Lys Glu Arg Ser Leu 
145                 150                 155                 160 


Ile Asn Lys Asn Ile Pro Asn Phe Lys Trp Leu Ala Gly Phe Thr Ser 
                165                 170                 175     


Gly Glu Gly Cys Phe Phe Val Asn Leu Ile Lys Ser Lys Ser Lys Leu 
            180                 185                 190         


Gly Val Gln Val Gln Leu Val Phe Ser Ile Thr Gln His Ile Lys Asp 
        195                 200                 205             


Lys Asn Leu Met Asn Ser Leu Ile Thr Tyr Leu Gly Cys Gly Tyr Ile 
    210                 215                 220                 


Lys Glu Lys Asn Lys Ser Glu Phe Ser Trp Leu Asp Phe Val Val Thr 
225                 230                 235                 240 


Lys Phe Ser Asp Ile Asn Asp Lys Ile Ile Pro Val Phe Gln Glu Asn 
                245                 250                 255     


Thr Leu Ile Gly Val Lys Leu Glu Asp Phe Glu Asp Trp Cys Lys Val 
            260                 265                 270         


Ala Lys Leu Ile Glu Glu Lys Lys His Leu Thr Glu Ser Gly Leu Asp 
        275                 280                 285             


Glu Ile Lys Lys Ile Lys Leu Asn Met Asn Lys Gly Arg Val Phe 
    290                 295                 300             


<210>  3
<211>  303
<212>  PRT
<213>  Ophiostoma novo-ulmi


<220>
<221>  MOD_RES
<222>  (1)..(3)
<223>  Any amino acid or absent

<400>  3

Xaa Xaa Xaa Met Ser Arg Arg Glu Ser Ile Asn Pro Trp Ile Leu Thr 
1               5                   10                  15      


Gly Phe Ala Asp Ala Glu Gly Ser Phe Leu Leu Arg Ile Arg Asn Asn 
            20                  25                  30          


Asn Lys Ser Ser Val Gly Tyr Ser Thr Glu Leu Gly Phe Gln Ile Thr 
        35                  40                  45              


Leu His Asn Lys Asp Lys Ser Ile Leu Glu Asn Ile Gln Ser Thr Trp 
    50                  55                  60                  


Lys Val Gly Val Ile Ala Asn Ser Gly Asp Asn Ala Val Ser Leu Lys 
65                  70                  75                  80  


Val Thr Arg Phe Glu Asp Leu Lys Val Ile Ile Asp His Phe Glu Lys 
                85                  90                  95      


Tyr Pro Leu Ile Thr Gln Lys Leu Gly Asp Tyr Lys Leu Phe Lys Gln 
            100                 105                 110         


Ala Phe Ser Val Met Glu Asn Lys Glu His Leu Lys Glu Asn Gly Ile 
        115                 120                 125             


Lys Glu Leu Val Arg Ile Lys Ala Lys Leu Asn Trp Gly Leu Thr Asp 
    130                 135                 140                 


Glu Leu Lys Lys Ala Phe Pro Glu Asn Ile Ser Lys Glu Arg Ser Leu 
145                 150                 155                 160 


Ile Asn Lys Asn Ile Pro Asn Phe Lys Trp Leu Ala Gly Phe Thr Ser 
                165                 170                 175     


Gly Glu Gly Cys Phe Phe Val Asn Leu Ile Lys Ser Lys Ser Lys Leu 
            180                 185                 190         


Gly Val Gln Val Gln Leu Val Phe Ser Ile Thr Gln His Ile Lys Asp 
        195                 200                 205             


Lys Asn Leu Met Asn Ser Leu Ile Thr Tyr Leu Gly Cys Gly Tyr Ile 
    210                 215                 220                 


Lys Glu Lys Asn Lys Ser Glu Phe Ser Trp Leu Asp Phe Val Val Thr 
225                 230                 235                 240 


Lys Phe Ser Asp Ile Asn Asp Lys Ile Ile Pro Val Phe Gln Glu Asn 
                245                 250                 255     


Thr Leu Ile Gly Val Lys Leu Glu Asp Phe Glu Asp Trp Cys Lys Val 
            260                 265                 270         


Ala Lys Leu Ile Glu Glu Lys Lys His Leu Thr Glu Ser Gly Leu Asp 
        275                 280                 285             


Glu Ile Lys Lys Ile Lys Leu Asn Met Asn Lys Gly Arg Val Phe 
    290                 295                 300             


<210>  4
<211>  303
<212>  PRT
<213>  Ophiostoma novo-ulmi


<220>
<221>  MOD_RES
<222>  (1)..(4)
<223>  Any amino acid or absent

<220>
<221>  MOD_RES
<222>  (302)..(303)
<223>  Any amino acid or absent

<400>  4

Xaa Xaa Xaa Xaa Ser Arg Arg Glu Ser Ile Asn Pro Trp Ile Leu Thr 
1               5                   10                  15      


Gly Phe Ala Asp Ala Glu Gly Ser Phe Leu Leu Arg Ile Arg Asn Asn 
            20                  25                  30          


Asn Lys Ser Ser Val Gly Tyr Ser Thr Glu Leu Gly Phe Gln Ile Thr 
        35                  40                  45              


Leu His Asn Lys Asp Lys Ser Ile Leu Glu Asn Ile Gln Ser Thr Trp 
    50                  55                  60                  


Lys Val Gly Val Ile Ala Asn Ser Gly Asp Asn Ala Val Ser Leu Lys 
65                  70                  75                  80  


Val Thr Arg Phe Glu Asp Leu Lys Val Ile Ile Asp His Phe Glu Lys 
                85                  90                  95      


Tyr Pro Leu Ile Thr Gln Lys Leu Gly Asp Tyr Lys Leu Phe Lys Gln 
            100                 105                 110         


Ala Phe Ser Val Met Glu Asn Lys Glu His Leu Lys Glu Asn Gly Ile 
        115                 120                 125             


Lys Glu Leu Val Arg Ile Lys Ala Lys Leu Asn Trp Gly Leu Thr Asp 
    130                 135                 140                 


Glu Leu Lys Lys Ala Phe Pro Glu Asn Ile Ser Lys Glu Arg Ser Leu 
145                 150                 155                 160 


Ile Asn Lys Asn Ile Pro Asn Phe Lys Trp Leu Ala Gly Phe Thr Ser 
                165                 170                 175     


Gly Glu Gly Cys Phe Phe Val Asn Leu Ile Lys Ser Lys Ser Lys Leu 
            180                 185                 190         


Gly Val Gln Val Gln Leu Val Phe Ser Ile Thr Gln His Ile Lys Asp 
        195                 200                 205             


Lys Asn Leu Met Asn Ser Leu Ile Thr Tyr Leu Gly Cys Gly Tyr Ile 
    210                 215                 220                 


Lys Glu Lys Asn Lys Ser Glu Phe Ser Trp Leu Asp Phe Val Val Thr 
225                 230                 235                 240 


Lys Phe Ser Asp Ile Asn Asp Lys Ile Ile Pro Val Phe Gln Glu Asn 
                245                 250                 255     


Thr Leu Ile Gly Val Lys Leu Glu Asp Phe Glu Asp Trp Cys Lys Val 
            260                 265                 270         


Ala Lys Leu Ile Glu Glu Lys Lys His Leu Thr Glu Ser Gly Leu Asp 
        275                 280                 285             


Glu Ile Lys Lys Ile Lys Leu Asn Met Asn Lys Gly Arg Xaa Xaa 
    290                 295                 300             


<210>  5
<211>  303
<212>  PRT
<213>  Ophiostoma novo-ulmi


<220>
<221>  MOD_RES
<222>  (1)..(8)
<223>  Any amino acid or absent

<220>
<221>  MOD_RES
<222>  (302)..(303)
<223>  Any amino acid or absent

<400>  5

Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Ser Ile Asn Pro Trp Ile Leu Thr 
1               5                   10                  15      


Gly Phe Ala Asp Ala Glu Gly Ser Phe Leu Leu Arg Ile Arg Asn Asn 
            20                  25                  30          


Asn Lys Ser Ser Val Gly Tyr Ser Thr Glu Leu Gly Phe Gln Ile Thr 
        35                  40                  45              


Leu His Asn Lys Asp Lys Ser Ile Leu Glu Asn Ile Gln Ser Thr Trp 
    50                  55                  60                  


Lys Val Gly Val Ile Ala Asn Ser Gly Asp Asn Ala Val Ser Leu Lys 
65                  70                  75                  80  


Val Thr Arg Phe Glu Asp Leu Lys Val Ile Ile Asp His Phe Glu Lys 
                85                  90                  95      


Tyr Pro Leu Ile Thr Gln Lys Leu Gly Asp Tyr Lys Leu Phe Lys Gln 
            100                 105                 110         


Ala Phe Ser Val Met Glu Asn Lys Glu His Leu Lys Glu Asn Gly Ile 
        115                 120                 125             


Lys Glu Leu Val Arg Ile Lys Ala Lys Leu Asn Trp Gly Leu Thr Asp 
    130                 135                 140                 


Glu Leu Lys Lys Ala Phe Pro Glu Asn Ile Ser Lys Glu Arg Ser Leu 
145                 150                 155                 160 


Ile Asn Lys Asn Ile Pro Asn Phe Lys Trp Leu Ala Gly Phe Thr Ser 
                165                 170                 175     


Gly Glu Gly Cys Phe Phe Val Asn Leu Ile Lys Ser Lys Ser Lys Leu 
            180                 185                 190         


Gly Val Gln Val Gln Leu Val Phe Ser Ile Thr Gln His Ile Lys Asp 
        195                 200                 205             


Lys Asn Leu Met Asn Ser Leu Ile Thr Tyr Leu Gly Cys Gly Tyr Ile 
    210                 215                 220                 


Lys Glu Lys Asn Lys Ser Glu Phe Ser Trp Leu Asp Phe Val Val Thr 
225                 230                 235                 240 


Lys Phe Ser Asp Ile Asn Asp Lys Ile Ile Pro Val Phe Gln Glu Asn 
                245                 250                 255     


Thr Leu Ile Gly Val Lys Leu Glu Asp Phe Glu Asp Trp Cys Lys Val 
            260                 265                 270         


Ala Lys Leu Ile Glu Glu Lys Lys His Leu Thr Glu Ser Gly Leu Asp 
        275                 280                 285             


Glu Ile Lys Lys Ile Lys Leu Asn Met Asn Lys Gly Arg Xaa Xaa 
    290                 295                 300             


<210>  6
<211>  303
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized I-OnuI variant

<400>  6

Met Ala Tyr Met Ser Arg Arg Glu Ser Ile Asn Pro Trp Ile Leu Thr 
1               5                   10                  15      


Gly Phe Ala Asp Ala Glu Gly Ser Phe Ile Leu Asp Ile Arg Asn Arg 
            20                  25                  30          


Asn Asn Glu Ser Asn Arg Tyr Arg Thr Ser Leu Arg Phe Gln Ile Thr 
        35                  40                  45              


Leu His Asn Lys Asp Lys Ser Ile Leu Glu Asn Ile Gln Ser Thr Trp 
    50                  55                  60                  


Lys Val Gly Lys Ile Thr Asn Ser Gly Asp Arg Ala Val Met Leu Arg 
65                  70                  75                  80  


Val Thr Arg Phe Glu Asp Leu Lys Val Ile Ile Asp His Phe Glu Lys 
                85                  90                  95      


Tyr Pro Leu Ile Thr Gln Lys Leu Gly Asp Tyr Lys Leu Phe Lys Gln 
            100                 105                 110         


Ala Phe Ser Val Met Glu Asn Lys Glu His Leu Lys Glu Asn Gly Ile 
        115                 120                 125             


Lys Glu Leu Val Arg Ile Lys Ala Lys Met Asn Trp Gly Leu Thr Asp 
    130                 135                 140                 


Glu Leu Lys Lys Ala Phe Pro Glu Asn Ile Ser Lys Glu Arg Pro Leu 
145                 150                 155                 160 


Ile Asn Lys Asn Ile Pro Asn Phe Lys Trp Leu Ala Gly Phe Thr Ser 
                165                 170                 175     


Gly Asp Gly Tyr Phe Gly Val Asn Leu Lys Lys Val Lys Gly Asn Ala 
            180                 185                 190         


Lys Val Tyr Val Gly Leu Arg Phe Ser Ile Ser Gln His Ile Arg Asp 
        195                 200                 205             


Lys Asn Leu Met Asn Ser Leu Ile Thr Tyr Leu Gly Cys Gly Ser Ile 
    210                 215                 220                 


Trp Glu Lys Asn Lys Ser Glu Phe Ser Trp Leu Glu Phe Val Val Thr 
225                 230                 235                 240 


Lys Phe Ser Asp Ile Asn Asp Lys Ile Ile Pro Val Phe Gln Glu Asn 
                245                 250                 255     


Thr Leu Ile Gly Val Lys Leu Glu Asp Phe Glu Asp Trp Cys Lys Val 
            260                 265                 270         


Ala Lys Leu Ile Glu Glu Lys Lys His Leu Thr Glu Ser Gly Leu Asp 
        275                 280                 285             


Glu Ile Lys Lys Ile Lys Leu Asn Met Asn Lys Gly Arg Val Phe 
    290                 295                 300             


<210>  7
<211>  303
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized I-OnuI LHE variant


<220>
<221>  MOD_RES
<222>  (1)..(4)
<223>  Any amino acid or absent

<220>
<221>  MOD_RES
<222>  (302)..(303)
<223>  Any amino acid or absent

<400>  7

Xaa Xaa Xaa Xaa Ser Arg Arg Glu Ser Ile Asn Pro Trp Ile Leu Thr 
1               5                   10                  15      


Gly Phe Ala Asp Ala Glu Gly Ser Phe Ile Leu Asp Ile Arg Asn Arg 
            20                  25                  30          


Asn Asn Glu Ser Asn Arg Tyr Arg Thr Ser Leu Arg Phe Gln Ile Thr 
        35                  40                  45              


Leu His Asn Lys Asp Lys Ser Ile Leu Glu Asn Ile Gln Ser Thr Trp 
    50                  55                  60                  


Lys Val Gly Lys Ile Thr Asn Ser Ser Asp Arg Ala Val Met Leu Arg 
65                  70                  75                  80  


Val Thr Arg Phe Glu Asp Leu Lys Val Ile Ile Asp His Phe Glu Lys 
                85                  90                  95      


Tyr Pro Leu Ile Thr Gln Lys Leu Gly Asp Tyr Lys Leu Phe Lys Gln 
            100                 105                 110         


Ala Phe Ser Val Met Glu Asn Lys Glu His Leu Lys Glu Asn Gly Ile 
        115                 120                 125             


Lys Glu Leu Val Arg Ile Lys Ala Lys Met Asn Trp Gly Leu Asn Asp 
    130                 135                 140                 


Glu Leu Lys Lys Ala Phe Pro Glu Asn Ile Ser Lys Glu Arg Pro Leu 
145                 150                 155                 160 


Ile Asn Lys Asn Ile Pro Asn Phe Lys Trp Leu Ala Gly Phe Thr Ala 
                165                 170                 175     


Gly Glu Gly His Phe Gly Val Asn Leu Lys Lys Val Lys Gly Thr Ala 
            180                 185                 190         


Lys Val Tyr Val Gly Leu Arg Phe Ala Ile Ser Gln His Ile Arg Asp 
        195                 200                 205             


Lys Asn Leu Met Asn Ser Leu Ile Thr Tyr Leu Gly Cys Gly Ser Ile 
    210                 215                 220                 


Arg Glu Lys Asn Lys Ser Glu Phe Arg Trp Leu Glu Phe Glu Val Thr 
225                 230                 235                 240 


Lys Phe Ser Asp Ile Asn Asp Lys Ile Ile Pro Val Phe Gln Glu Asn 
                245                 250                 255     


Thr Leu Ile Gly Val Lys Leu Glu Asp Phe Glu Asp Trp Cys Lys Val 
            260                 265                 270         


Ala Lys Leu Ile Glu Glu Lys Lys His Leu Thr Glu Ser Gly Leu Asp 
        275                 280                 285             


Glu Ile Lys Lys Ile Lys Leu Asn Met Asn Lys Gly Arg Xaa Xaa 
    290                 295                 300             


<210>  8
<211>  303
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized I-OnuI LHE variant


<220>
<221>  MOD_RES
<222>  (1)..(4)
<223>  Any amino acid or absent

<220>
<221>  MOD_RES
<222>  (302)..(303)
<223>  Any amino acid or absent

<400>  8

Xaa Xaa Xaa Xaa Ser Arg Arg Glu Ser Ile Asn Pro Trp Ile Leu Thr 
1               5                   10                  15      


Gly Phe Ala Asp Ala Glu Gly Ser Phe Ile Leu Asp Ile Arg Asn Arg 
            20                  25                  30          


Asn Asn Glu Ser Asn Arg Tyr Arg Thr Ser Leu Arg Phe Gln Ile Thr 
        35                  40                  45              


Leu His Asn Lys Asp Lys Ser Ile Leu Glu Asn Ile Gln Ser Thr Trp 
    50                  55                  60                  


Lys Val Gly Lys Ile Thr Asn Ser Ser Asp Arg Ala Val Met Leu Arg 
65                  70                  75                  80  


Val Thr Arg Phe Glu Asp Leu Lys Val Ile Ile Asp His Phe Glu Lys 
                85                  90                  95      


Tyr Pro Leu Ile Thr Gln Lys Leu Gly Asp Tyr Lys Leu Phe Lys Gln 
            100                 105                 110         


Ala Phe Ser Val Met Glu Asn Lys Glu His Leu Lys Glu Asn Gly Ile 
        115                 120                 125             


Lys Glu Leu Val Arg Ile Lys Ala Lys Met Asn Trp Gly Leu Asn Asp 
    130                 135                 140                 


Glu Leu Lys Lys Ala Phe Pro Glu Asn Ile Ser Lys Glu Arg Pro Leu 
145                 150                 155                 160 


Ile Asn Lys Asn Ile Pro Asn Phe Lys Trp Leu Ala Gly Phe Thr Ala 
                165                 170                 175     


Gly Asp Gly His Phe Gly Val Asn Leu Lys Lys Val Lys Gly Thr Ala 
            180                 185                 190         


Lys Val Tyr Val Gly Leu Arg Phe Ala Ile Ser Gln His Ile Arg Asp 
        195                 200                 205             


Lys Asn Leu Met Asn Ser Leu Ile Thr Tyr Leu Gly Cys Gly Ser Ile 
    210                 215                 220                 


Arg Glu Lys Asn Lys Ser Glu Phe Arg Trp Leu Glu Phe Glu Val Thr 
225                 230                 235                 240 


Lys Phe Ser Asp Ile Asn Asp Lys Ile Ile Pro Val Phe Gln Glu Asn 
                245                 250                 255     


Thr Leu Ile Gly Val Lys Leu Glu Asp Phe Glu Asp Trp Cys Lys Val 
            260                 265                 270         


Ala Lys Leu Ile Glu Glu Lys Lys His Leu Thr Glu Ser Gly Leu Asp 
        275                 280                 285             


Glu Ile Lys Lys Ile Lys Leu Asn Met Asn Lys Gly Arg Xaa Xaa 
    290                 295                 300             


<210>  9
<211>  877
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized I-OnuI variant megaTAL construct

<400>  9

Met Gly Ser Ala Pro Pro Lys Lys Lys Arg Lys Val Val Asp Leu Arg 
1               5                   10                  15      


Thr Leu Gly Tyr Ser Gln Gln Gln Gln Glu Lys Ile Lys Pro Lys Val 
            20                  25                  30          


Arg Ser Thr Val Ala Gln His His Glu Ala Leu Val Gly His Gly Phe 
        35                  40                  45              


Thr His Ala His Ile Val Ala Leu Ser Gln His Pro Ala Ala Leu Gly 
    50                  55                  60                  


Thr Val Ala Val Thr Tyr Gln His Ile Ile Thr Ala Leu Pro Glu Ala 
65                  70                  75                  80  


Thr His Glu Asp Ile Val Gly Val Gly Lys Gln Trp Ser Gly Ala Arg 
                85                  90                  95      


Ala Leu Glu Ala Leu Leu Thr Asp Ala Gly Glu Leu Arg Gly Pro Pro 
            100                 105                 110         


Leu Gln Leu Asp Thr Gly Gln Leu Val Lys Ile Ala Lys Arg Gly Gly 
        115                 120                 125             


Val Thr Ala Met Glu Ala Val His Ala Ser Arg Asn Ala Leu Thr Gly 
    130                 135                 140                 


Ala Pro Leu Asn Leu Thr Pro Asp Gln Val Val Ala Ile Ala Ser Asn 
145                 150                 155                 160 


Ile Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu Leu Pro Val 
                165                 170                 175     


Leu Cys Gln Asp His Gly Leu Thr Pro Asp Gln Val Val Ala Ile Ala 
            180                 185                 190         


Ser Asn Ile Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu Leu 
        195                 200                 205             


Pro Val Leu Cys Gln Asp His Gly Leu Thr Pro Asp Gln Val Val Ala 
    210                 215                 220                 


Ile Ala Ser Asn Ile Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg 
225                 230                 235                 240 


Leu Leu Pro Val Leu Cys Gln Asp His Gly Leu Thr Pro Asp Gln Val 
                245                 250                 255     


Val Ala Ile Ala Ser Asn Gly Gly Gly Lys Gln Ala Leu Glu Thr Val 
            260                 265                 270         


Gln Arg Leu Leu Pro Val Leu Cys Gln Asp His Gly Leu Thr Pro Asp 
        275                 280                 285             


Gln Val Val Ala Ile Ala Ser His Asp Gly Gly Lys Gln Ala Leu Glu 
    290                 295                 300                 


Thr Val Gln Arg Leu Leu Pro Val Leu Cys Gln Asp His Gly Leu Thr 
305                 310                 315                 320 


Pro Asp Gln Val Val Ala Ile Ala Ser His Asp Gly Gly Lys Gln Ala 
                325                 330                 335     


Leu Glu Thr Val Gln Arg Leu Leu Pro Val Leu Cys Gln Asp His Gly 
            340                 345                 350         


Leu Thr Pro Asp Gln Val Val Ala Ile Ala Ser Asn Ile Gly Gly Lys 
        355                 360                 365             


Gln Ala Leu Glu Thr Val Gln Arg Leu Leu Pro Val Leu Cys Gln Asp 
    370                 375                 380                 


His Gly Leu Thr Pro Asp Gln Val Val Ala Ile Ala Ser Asn Asn Gly 
385                 390                 395                 400 


Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu Leu Pro Val Leu Cys 
                405                 410                 415     


Gln Asp His Gly Leu Thr Pro Asp Gln Val Val Ala Ile Ala Ser Asn 
            420                 425                 430         


Gly Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu Leu Pro Val 
        435                 440                 445             


Leu Cys Gln Asp His Gly Leu Thr Pro Asp Gln Val Val Ala Ile Ala 
    450                 455                 460                 


Ser Asn Asn Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu Leu 
465                 470                 475                 480 


Pro Val Leu Cys Gln Asp His Gly Leu Thr Pro Asp Gln Val Val Ala 
                485                 490                 495     


Ile Ala Ser Asn Ile Gly Gly Lys Gln Ala Leu Glu Ser Ile Val Ala 
            500                 505                 510         


Gln Leu Ser Arg Pro Asp Pro Ala Leu Ala Ala Leu Thr Asn Asp His 
        515                 520                 525             


Leu Val Ala Leu Ala Cys Leu Gly Gly Arg Pro Ala Met Asp Ala Val 
    530                 535                 540                 


Lys Lys Gly Leu Pro His Ala Pro Glu Leu Ile Arg Arg Val Asn Arg 
545                 550                 555                 560 


Arg Ile Gly Glu Arg Thr Ser His Arg Val Ala Ile Ser Arg Val Gly 
                565                 570                 575     


Gly Ser Ser Arg Arg Glu Ser Ile Asn Pro Trp Ile Leu Thr Gly Phe 
            580                 585                 590         


Ala Asp Ala Glu Gly Ser Phe Ile Leu Asp Ile Arg Asn Arg Asn Asn 
        595                 600                 605             


Glu Ser Asn Arg Tyr Arg Thr Ser Leu Arg Phe Gln Ile Thr Leu His 
    610                 615                 620                 


Asn Lys Asp Lys Ser Ile Leu Glu Asn Ile Gln Ser Thr Trp Lys Val 
625                 630                 635                 640 


Gly Lys Ile Thr Asn Ser Gly Asp Arg Ala Val Met Leu Arg Val Thr 
                645                 650                 655     


Arg Phe Glu Asp Leu Lys Val Ile Ile Asp His Phe Glu Lys Tyr Pro 
            660                 665                 670         


Leu Ile Thr Gln Lys Leu Gly Asp Tyr Lys Leu Phe Lys Gln Ala Phe 
        675                 680                 685             


Ser Val Met Glu Asn Lys Glu His Leu Lys Glu Asn Gly Ile Lys Glu 
    690                 695                 700                 


Leu Val Arg Ile Lys Ala Lys Met Asn Trp Gly Leu Thr Asp Glu Leu 
705                 710                 715                 720 


Lys Lys Ala Phe Pro Glu Asn Ile Ser Lys Glu Arg Pro Leu Ile Asn 
                725                 730                 735     


Lys Asn Ile Pro Asn Phe Lys Trp Leu Ala Gly Phe Thr Ser Gly Asp 
            740                 745                 750         


Gly Tyr Phe Gly Val Asn Leu Lys Lys Val Lys Gly Asn Ala Lys Val 
        755                 760                 765             


Tyr Val Gly Leu Arg Phe Ser Ile Ser Gln His Ile Arg Asp Lys Asn 
    770                 775                 780                 


Leu Met Asn Ser Leu Ile Thr Tyr Leu Gly Cys Gly Ser Ile Trp Glu 
785                 790                 795                 800 


Lys Asn Lys Ser Glu Phe Ser Trp Leu Glu Phe Val Val Thr Lys Phe 
                805                 810                 815     


Ser Asp Ile Asn Asp Lys Ile Ile Pro Val Phe Gln Glu Asn Thr Leu 
            820                 825                 830         


Ile Gly Val Lys Leu Glu Asp Phe Glu Asp Trp Cys Lys Val Ala Lys 
        835                 840                 845             


Leu Ile Glu Glu Lys Lys His Leu Thr Glu Ser Gly Leu Asp Glu Ile 
    850                 855                 860                 


Lys Lys Ile Lys Leu Asn Met Asn Lys Gly Arg Val Phe 
865                 870                 875         


<210>  10
<211>  877
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized megaTAL construct

<400>  10

Met Gly Ser Ala Pro Pro Lys Lys Lys Arg Lys Val Val Asp Leu Arg 
1               5                   10                  15      


Thr Leu Gly Tyr Ser Gln Gln Gln Gln Glu Lys Ile Lys Pro Lys Val 
            20                  25                  30          


Arg Ser Thr Val Ala Gln His His Glu Ala Leu Val Gly His Gly Phe 
        35                  40                  45              


Thr His Ala His Ile Val Ala Leu Ser Gln His Pro Ala Ala Leu Gly 
    50                  55                  60                  


Thr Val Ala Val Thr Tyr Gln His Ile Ile Thr Ala Leu Pro Glu Ala 
65                  70                  75                  80  


Thr His Glu Asp Ile Val Gly Val Gly Lys Gln Trp Ser Gly Ala Arg 
                85                  90                  95      


Ala Leu Glu Ala Leu Leu Thr Asp Ala Gly Glu Leu Arg Gly Pro Pro 
            100                 105                 110         


Leu Gln Leu Asp Thr Gly Gln Leu Val Lys Ile Ala Lys Arg Gly Gly 
        115                 120                 125             


Val Thr Ala Met Glu Ala Val His Ala Ser Arg Asn Ala Leu Thr Gly 
    130                 135                 140                 


Ala Pro Leu Asn Leu Thr Pro Asp Gln Val Val Ala Ile Ala Ser Asn 
145                 150                 155                 160 


Ile Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu Leu Pro Val 
                165                 170                 175     


Leu Cys Gln Asp His Gly Leu Thr Pro Asp Gln Val Val Ala Ile Ala 
            180                 185                 190         


Ser Asn Ile Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu Leu 
        195                 200                 205             


Pro Val Leu Cys Gln Asp His Gly Leu Thr Pro Asp Gln Val Val Ala 
    210                 215                 220                 


Ile Ala Ser Asn Ile Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg 
225                 230                 235                 240 


Leu Leu Pro Val Leu Cys Gln Asp His Gly Leu Thr Pro Asp Gln Val 
                245                 250                 255     


Val Ala Ile Ala Ser Asn Gly Gly Gly Lys Gln Ala Leu Glu Thr Val 
            260                 265                 270         


Gln Arg Leu Leu Pro Val Leu Cys Gln Asp His Gly Leu Thr Pro Asp 
        275                 280                 285             


Gln Val Val Ala Ile Ala Ser His Asp Gly Gly Lys Gln Ala Leu Glu 
    290                 295                 300                 


Thr Val Gln Arg Leu Leu Pro Val Leu Cys Gln Asp His Gly Leu Thr 
305                 310                 315                 320 


Pro Asp Gln Val Val Ala Ile Ala Ser His Asp Gly Gly Lys Gln Ala 
                325                 330                 335     


Leu Glu Thr Val Gln Arg Leu Leu Pro Val Leu Cys Gln Asp His Gly 
            340                 345                 350         


Leu Thr Pro Asp Gln Val Val Ala Ile Ala Ser Asn Ile Gly Gly Lys 
        355                 360                 365             


Gln Ala Leu Glu Thr Val Gln Arg Leu Leu Pro Val Leu Cys Gln Asp 
    370                 375                 380                 


His Gly Leu Thr Pro Asp Gln Val Val Ala Ile Ala Ser Asn Asn Gly 
385                 390                 395                 400 


Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu Leu Pro Val Leu Cys 
                405                 410                 415     


Gln Asp His Gly Leu Thr Pro Asp Gln Val Val Ala Ile Ala Ser Asn 
            420                 425                 430         


Gly Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu Leu Pro Val 
        435                 440                 445             


Leu Cys Gln Asp His Gly Leu Thr Pro Asp Gln Val Val Ala Ile Ala 
    450                 455                 460                 


Ser Asn Asn Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu Leu 
465                 470                 475                 480 


Pro Val Leu Cys Gln Asp His Gly Leu Thr Pro Asp Gln Val Val Ala 
                485                 490                 495     


Ile Ala Ser Asn Ile Gly Gly Lys Gln Ala Leu Glu Ser Ile Val Ala 
            500                 505                 510         


Gln Leu Ser Arg Pro Asp Pro Ala Leu Ala Ala Leu Thr Asn Asp His 
        515                 520                 525             


Leu Val Ala Leu Ala Cys Leu Gly Gly Arg Pro Ala Met Asp Ala Val 
    530                 535                 540                 


Lys Lys Gly Leu Pro His Ala Pro Glu Leu Ile Arg Arg Val Asn Arg 
545                 550                 555                 560 


Arg Ile Gly Glu Arg Thr Ser His Arg Val Ala Ile Ser Arg Val Gly 
                565                 570                 575     


Gly Ser Ser Arg Arg Glu Ser Ile Asn Pro Trp Ile Leu Thr Gly Phe 
            580                 585                 590         


Ala Asp Ala Glu Gly Ser Phe Ile Leu Asp Ile Arg Asn Arg Asn Asn 
        595                 600                 605             


Glu Ser Asn Arg Tyr Arg Thr Ser Leu Arg Phe Gln Ile Thr Leu His 
    610                 615                 620                 


Asn Lys Asp Lys Ser Ile Leu Glu Asn Ile Gln Ser Thr Trp Lys Val 
625                 630                 635                 640 


Gly Lys Ile Thr Asn Ser Gly Asp Arg Ala Val Met Leu Arg Val Thr 
                645                 650                 655     


Arg Phe Glu Asp Leu Lys Val Ile Ile Asp His Phe Glu Lys Tyr Pro 
            660                 665                 670         


Leu Ile Thr Gln Lys Leu Gly Asp Tyr Lys Leu Phe Lys Gln Ala Phe 
        675                 680                 685             


Ser Val Met Glu Asn Lys Glu His Leu Lys Glu Asn Gly Ile Lys Glu 
    690                 695                 700                 


Leu Val Arg Ile Lys Ala Lys Met Asn Trp Gly Leu Thr Asp Glu Leu 
705                 710                 715                 720 


Lys Lys Ala Phe Pro Glu Asn Ile Ser Lys Glu Arg Pro Leu Ile Asn 
                725                 730                 735     


Lys Asn Ile Pro Asn Phe Lys Trp Leu Ala Gly Phe Thr Ser Gly Asp 
            740                 745                 750         


Gly Tyr Phe Gly Val Asn Leu Lys Lys Val Lys Gly Asn Ala Lys Val 
        755                 760                 765             


Tyr Val Gly Leu Arg Phe Ser Ile Ser Gln His Ile Arg Asp Lys Asn 
    770                 775                 780                 


Leu Met Asn Ser Leu Ile Thr Tyr Leu Gly Cys Gly Ser Ile Trp Glu 
785                 790                 795                 800 


Lys Asn Lys Ser Glu Phe Ser Trp Leu Glu Phe Val Val Thr Lys Phe 
                805                 810                 815     


Ser Asp Ile Asn Asp Lys Ile Ile Pro Val Phe Gln Glu Asn Thr Leu 
            820                 825                 830         


Ile Gly Val Lys Leu Glu Asp Phe Glu Asp Trp Cys Lys Val Ala Lys 
        835                 840                 845             


Leu Ile Glu Glu Lys Lys His Leu Thr Glu Ser Gly Leu Asp Glu Ile 
    850                 855                 860                 


Lys Lys Ile Lys Leu Asn Met Asn Lys Gly Arg Val Phe 
865                 870                 875         


<210>  11
<211>  875
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized megaTAL construct

<400>  11

Met Gly Ser Ala Pro Pro Lys Lys Lys Arg Lys Val Val Asp Leu Arg 
1               5                   10                  15      


Thr Leu Gly Tyr Ser Gln Gln Gln Gln Glu Lys Ile Lys Pro Lys Val 
            20                  25                  30          


Arg Ser Thr Val Ala Gln His His Glu Ala Leu Val Gly His Gly Phe 
        35                  40                  45              


Thr His Ala His Ile Val Ala Leu Ser Gln His Pro Ala Ala Leu Gly 
    50                  55                  60                  


Thr Val Ala Val Thr Tyr Gln His Ile Ile Thr Ala Leu Pro Glu Ala 
65                  70                  75                  80  


Thr His Glu Asp Ile Val Gly Val Gly Lys Gln Trp Ser Gly Ala Arg 
                85                  90                  95      


Ala Leu Glu Ala Leu Leu Thr Asp Ala Gly Glu Leu Arg Gly Pro Pro 
            100                 105                 110         


Leu Gln Leu Asp Thr Gly Gln Leu Val Lys Ile Ala Lys Arg Gly Gly 
        115                 120                 125             


Val Thr Ala Met Glu Ala Val His Ala Ser Arg Asn Ala Leu Thr Gly 
    130                 135                 140                 


Ala Pro Leu Asn Leu Thr Pro Asp Gln Val Val Ala Ile Ala Ser Asn 
145                 150                 155                 160 


Ile Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu Leu Pro Val 
                165                 170                 175     


Leu Cys Gln Asp His Gly Leu Thr Pro Asp Gln Val Val Ala Ile Ala 
            180                 185                 190         


Ser Asn Ile Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu Leu 
        195                 200                 205             


Pro Val Leu Cys Gln Asp His Gly Leu Thr Pro Asp Gln Val Val Ala 
    210                 215                 220                 


Ile Ala Ser Asn Ile Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg 
225                 230                 235                 240 


Leu Leu Pro Val Leu Cys Gln Asp His Gly Leu Thr Pro Asp Gln Val 
                245                 250                 255     


Val Ala Ile Ala Ser Asn Gly Gly Gly Lys Gln Ala Leu Glu Thr Val 
            260                 265                 270         


Gln Arg Leu Leu Pro Val Leu Cys Gln Asp His Gly Leu Thr Pro Asp 
        275                 280                 285             


Gln Val Val Ala Ile Ala Ser His Asp Gly Gly Lys Gln Ala Leu Glu 
    290                 295                 300                 


Thr Val Gln Arg Leu Leu Pro Val Leu Cys Gln Asp His Gly Leu Thr 
305                 310                 315                 320 


Pro Asp Gln Val Val Ala Ile Ala Ser His Asp Gly Gly Lys Gln Ala 
                325                 330                 335     


Leu Glu Thr Val Gln Arg Leu Leu Pro Val Leu Cys Gln Asp His Gly 
            340                 345                 350         


Leu Thr Pro Asp Gln Val Val Ala Ile Ala Ser Asn Ile Gly Gly Lys 
        355                 360                 365             


Gln Ala Leu Glu Thr Val Gln Arg Leu Leu Pro Val Leu Cys Gln Asp 
    370                 375                 380                 


His Gly Leu Thr Pro Asp Gln Val Val Ala Ile Ala Ser Asn Asn Gly 
385                 390                 395                 400 


Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu Leu Pro Val Leu Cys 
                405                 410                 415     


Gln Asp His Gly Leu Thr Pro Asp Gln Val Val Ala Ile Ala Ser Asn 
            420                 425                 430         


Gly Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu Leu Pro Val 
        435                 440                 445             


Leu Cys Gln Asp His Gly Leu Thr Pro Asp Gln Val Val Ala Ile Ala 
    450                 455                 460                 


Ser Asn Asn Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu Leu 
465                 470                 475                 480 


Pro Val Leu Cys Gln Asp His Gly Leu Thr Pro Asp Gln Val Val Ala 
                485                 490                 495     


Ile Ala Ser Asn Ile Gly Gly Lys Gln Ala Leu Glu Ser Ile Val Ala 
            500                 505                 510         


Gln Leu Ser Arg Pro Asp Pro Ala Leu Ala Ala Leu Thr Asn Asp His 
        515                 520                 525             


Leu Val Ala Leu Ala Cys Leu Gly Gly Arg Pro Ala Met Asp Ala Val 
    530                 535                 540                 


Lys Lys Gly Leu Pro His Ala Pro Glu Leu Ile Arg Arg Val Asn Arg 
545                 550                 555                 560 


Arg Ile Gly Glu Arg Thr Ser His Arg Val Ala Ile Ser Arg Val Gly 
                565                 570                 575     


Gly Ser Ser Arg Arg Glu Ser Ile Asn Pro Trp Ile Leu Thr Gly Phe 
            580                 585                 590         


Ala Asp Ala Glu Gly Ser Phe Ile Leu Asp Ile Arg Asn Arg Asn Asn 
        595                 600                 605             


Glu Ser Asn Arg Tyr Arg Thr Ser Leu Arg Phe Gln Ile Thr Leu His 
    610                 615                 620                 


Asn Lys Asp Lys Ser Ile Leu Glu Asn Ile Gln Ser Thr Trp Lys Val 
625                 630                 635                 640 


Gly Lys Ile Thr Asn Ser Ser Asp Arg Ala Val Met Leu Arg Val Thr 
                645                 650                 655     


Arg Phe Glu Asp Leu Lys Val Ile Ile Asp His Phe Glu Lys Tyr Pro 
            660                 665                 670         


Leu Ile Thr Gln Lys Leu Gly Asp Tyr Lys Leu Phe Lys Gln Ala Phe 
        675                 680                 685             


Ser Val Met Glu Asn Lys Glu His Leu Lys Glu Asn Gly Ile Lys Glu 
    690                 695                 700                 


Leu Val Arg Ile Lys Ala Lys Met Asn Trp Gly Leu Asn Asp Glu Leu 
705                 710                 715                 720 


Lys Lys Ala Phe Pro Glu Asn Ile Ser Lys Glu Arg Pro Leu Ile Asn 
                725                 730                 735     


Lys Asn Ile Pro Asn Phe Lys Trp Leu Ala Gly Phe Thr Ala Gly Asp 
            740                 745                 750         


Gly His Phe Gly Val Asn Leu Lys Lys Val Lys Gly Thr Ala Lys Val 
        755                 760                 765             


Tyr Val Gly Leu Arg Phe Ala Ile Ser Gln His Ile Arg Asp Lys Asn 
    770                 775                 780                 


Leu Met Asn Ser Leu Ile Thr Tyr Leu Gly Cys Gly Ser Ile Arg Glu 
785                 790                 795                 800 


Lys Asn Lys Ser Glu Phe Arg Trp Leu Glu Phe Glu Val Thr Lys Phe 
                805                 810                 815     


Ser Asp Ile Asn Asp Lys Ile Ile Pro Val Phe Gln Glu Asn Thr Leu 
            820                 825                 830         


Ile Gly Val Lys Leu Glu Asp Phe Glu Asp Trp Cys Lys Val Ala Lys 
        835                 840                 845             


Leu Ile Glu Glu Lys Lys His Leu Thr Glu Ser Gly Leu Asp Glu Ile 
    850                 855                 860                 


Lys Lys Ile Lys Leu Asn Met Asn Lys Gly Arg 
865                 870                 875 


<210>  12
<211>  909
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized megaTAL construct

<400>  12

Met Gly Ser Ala Pro Pro Lys Lys Lys Arg Lys Val Val Asp Leu Arg 
1               5                   10                  15      


Thr Leu Gly Tyr Ser Gln Gln Gln Gln Glu Lys Ile Lys Pro Lys Val 
            20                  25                  30          


Arg Ser Thr Val Ala Gln His His Glu Ala Leu Val Gly His Gly Phe 
        35                  40                  45              


Thr His Ala His Ile Val Ala Leu Ser Gln His Pro Ala Ala Leu Gly 
    50                  55                  60                  


Thr Val Ala Val Thr Tyr Gln His Ile Ile Thr Ala Leu Pro Glu Ala 
65                  70                  75                  80  


Thr His Glu Asp Ile Val Gly Val Gly Lys Gln Trp Ser Gly Ala Arg 
                85                  90                  95      


Ala Leu Glu Ala Leu Leu Thr Asp Ala Gly Glu Leu Arg Gly Pro Pro 
            100                 105                 110         


Leu Gln Leu Asp Thr Gly Gln Leu Val Lys Ile Ala Lys Arg Gly Gly 
        115                 120                 125             


Val Thr Ala Met Glu Ala Val His Ala Ser Arg Asn Ala Leu Thr Gly 
    130                 135                 140                 


Ala Pro Leu Asn Leu Thr Pro Asp Gln Val Val Ala Ile Ala Ser Asn 
145                 150                 155                 160 


Ile Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu Leu Pro Val 
                165                 170                 175     


Leu Cys Gln Asp His Gly Leu Thr Pro Asp Gln Val Val Ala Ile Ala 
            180                 185                 190         


Ser Asn Ile Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu Leu 
        195                 200                 205             


Pro Val Leu Cys Gln Asp His Gly Leu Thr Pro Asp Gln Val Val Ala 
    210                 215                 220                 


Ile Ala Ser Asn Ile Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg 
225                 230                 235                 240 


Leu Leu Pro Val Leu Cys Gln Asp His Gly Leu Thr Pro Asp Gln Val 
                245                 250                 255     


Val Ala Ile Ala Ser Asn Gly Gly Gly Lys Gln Ala Leu Glu Thr Val 
            260                 265                 270         


Gln Arg Leu Leu Pro Val Leu Cys Gln Asp His Gly Leu Thr Pro Asp 
        275                 280                 285             


Gln Val Val Ala Ile Ala Ser His Asp Gly Gly Lys Gln Ala Leu Glu 
    290                 295                 300                 


Thr Val Gln Arg Leu Leu Pro Val Leu Cys Gln Asp His Gly Leu Thr 
305                 310                 315                 320 


Pro Asp Gln Val Val Ala Ile Ala Ser His Asp Gly Gly Lys Gln Ala 
                325                 330                 335     


Leu Glu Thr Val Gln Arg Leu Leu Pro Val Leu Cys Gln Asp His Gly 
            340                 345                 350         


Leu Thr Pro Asp Gln Val Val Ala Ile Ala Ser Asn Ile Gly Gly Lys 
        355                 360                 365             


Gln Ala Leu Glu Thr Val Gln Arg Leu Leu Pro Val Leu Cys Gln Asp 
    370                 375                 380                 


His Gly Leu Thr Pro Asp Gln Val Val Ala Ile Ala Ser Asn Asn Gly 
385                 390                 395                 400 


Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu Leu Pro Val Leu Cys 
                405                 410                 415     


Gln Asp His Gly Leu Thr Pro Asp Gln Val Val Ala Ile Ala Ser Asn 
            420                 425                 430         


Gly Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu Leu Pro Val 
        435                 440                 445             


Leu Cys Gln Asp His Gly Leu Thr Pro Asp Gln Val Val Ala Ile Ala 
    450                 455                 460                 


Ser Asn Asn Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu Leu 
465                 470                 475                 480 


Pro Val Leu Cys Gln Asp His Gly Leu Thr Pro Asp Gln Val Val Ala 
                485                 490                 495     


Ile Ala Ser Asn Ile Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg 
            500                 505                 510         


Leu Leu Pro Val Leu Cys Gln Asp His Gly Leu Thr Pro Asp Gln Val 
        515                 520                 525             


Val Ala Ile Ala Ser His Asp Gly Gly Lys Gln Ala Leu Glu Ser Ile 
    530                 535                 540                 


Val Ala Gln Leu Ser Arg Pro Asp Pro Ala Leu Ala Ala Leu Thr Asn 
545                 550                 555                 560 


Asp His Leu Val Ala Leu Ala Cys Leu Gly Gly Arg Pro Ala Met Asp 
                565                 570                 575     


Ala Val Lys Lys Gly Leu Pro His Ala Pro Glu Leu Ile Arg Arg Val 
            580                 585                 590         


Asn Arg Arg Ile Gly Glu Arg Thr Ser His Arg Val Ala Ile Ser Arg 
        595                 600                 605             


Val Gly Gly Ser Ser Arg Arg Glu Ser Ile Asn Pro Trp Ile Leu Thr 
    610                 615                 620                 


Gly Phe Ala Asp Ala Glu Gly Ser Phe Ile Leu Asp Ile Arg Asn Arg 
625                 630                 635                 640 


Asn Asn Glu Ser Asn Arg Tyr Arg Thr Ser Leu Arg Phe Gln Ile Thr 
                645                 650                 655     


Leu His Asn Lys Asp Lys Ser Ile Leu Glu Asn Ile Gln Ser Thr Trp 
            660                 665                 670         


Lys Val Gly Lys Ile Thr Asn Ser Ser Asp Arg Ala Val Met Leu Arg 
        675                 680                 685             


Val Thr Arg Phe Glu Asp Leu Lys Val Ile Ile Asp His Phe Glu Lys 
    690                 695                 700                 


Tyr Pro Leu Ile Thr Gln Lys Leu Gly Asp Tyr Lys Leu Phe Lys Gln 
705                 710                 715                 720 


Ala Phe Ser Val Met Glu Asn Lys Glu His Leu Lys Glu Asn Gly Ile 
                725                 730                 735     


Lys Glu Leu Val Arg Ile Lys Ala Lys Met Asn Trp Gly Leu Asn Asp 
            740                 745                 750         


Glu Leu Lys Lys Ala Phe Pro Glu Asn Ile Ser Lys Glu Arg Pro Leu 
        755                 760                 765             


Ile Asn Lys Asn Ile Pro Asn Phe Lys Trp Leu Ala Gly Phe Thr Ala 
    770                 775                 780                 


Gly Asp Gly His Phe Gly Val Asn Leu Lys Lys Val Lys Gly Thr Ala 
785                 790                 795                 800 


Lys Val Tyr Val Gly Leu Arg Phe Ala Ile Ser Gln His Ile Arg Asp 
                805                 810                 815     


Lys Asn Leu Met Asn Ser Leu Ile Thr Tyr Leu Gly Cys Gly Ser Ile 
            820                 825                 830         


Arg Glu Lys Asn Lys Ser Glu Phe Arg Trp Leu Glu Phe Glu Val Thr 
        835                 840                 845             


Lys Phe Ser Asp Ile Asn Asp Lys Ile Ile Pro Val Phe Gln Glu Asn 
    850                 855                 860                 


Thr Leu Ile Gly Val Lys Leu Glu Asp Phe Glu Asp Trp Cys Lys Val 
865                 870                 875                 880 


Ala Lys Leu Ile Glu Glu Lys Lys His Leu Thr Glu Ser Gly Leu Asp 
                885                 890                 895     


Glu Ile Lys Lys Ile Lys Leu Asn Met Asn Lys Gly Arg 
            900                 905                 


<210>  13
<211>  2634
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthesized I-OnuI variant megaTAL construct

<400>  13
augggauccg cgccaccuaa gaagaaacgc aaagucgugg aucuacgcac gcucggcuac       60

agucagcagc agcaagagaa gaucaaaccg aaggugcguu cgacaguggc gcagcaccac      120

gaggcacugg ugggccaugg guuuacacac gcgcacaucg uugcgcucag ccaacacccg      180

gcagcguuag ggaccgucgc ugucacguau cagcacauaa ucacggcguu gccagaggcg      240

acacacgaag acaucguugg cgucggcaaa cagugguccg gcgcacgcgc ccuggaggcc      300

uugcucacgg augcggggga guugagaggu ccgccguuac aguuggacac aggccaacuu      360

gugaagauug caaaacgugg cggcgugacc gcaauggagg cagugcaugc aucgcgcaau      420

gcacugacgg gugccccccu gaaccugacc ccggaccaag ugguggcuau cgccagcaac      480

auuggcggca agcaagcgcu cgaaacggug cagcggcugu ugccggugcu gugccaggac      540

cauggccuga ccccggacca agugguggcu aucgccagca acauuggcgg caagcaagcg      600

cucgaaacgg ugcagcggcu guugccggug cugugccagg accauggccu gaccccggac      660

caaguggugg cuaucgccag caacauuggc ggcaagcaag cgcucgaaac ggugcagcgg      720

cuguugccgg ugcugugcca ggaccauggc cugaccccgg accaaguggu ggcuaucgcc      780

agcaacggug gcggcaagca agcgcucgaa acggugcagc ggcuguugcc ggugcugugc      840

caggaccaug gccugacucc ggaccaagug guggcuaucg ccagccacga uggcggcaag      900

caagcgcucg aaacggugca gcggcuguug ccggugcugu gccaggacca uggccugacu      960

ccggaccaag ugguggcuau cgccagccac gauggcggca agcaagcgcu cgaaacggug     1020

cagcggcugu ugccggugcu gugccaggac cauggccuga ccccggacca agugguggcu     1080

aucgccagca acauuggcgg caagcaagcg cucgaaacgg ugcagcggcu guugccggug     1140

cugugccagg accauggccu gaccccggac caaguggugg cuaucgccag caacaauggc     1200

ggcaagcaag cgcucgaaac ggugcagcgg cuguugccgg ugcugugcca ggaccauggc     1260

cugaccccgg accaaguggu ggcuaucgcc agcaacggug gcggcaagca agcgcucgaa     1320

acggugcagc ggcuguugcc ggugcugugc caggaccaug gccugacccc ggaccaagug     1380

guggcuaucg ccagcaacaa uggcggcaag caagcgcucg aaacggugca gcggcuguug     1440

ccggugcugu gccaggacca uggccugacc ccggaccaag ugguggcuau cgccagcaac     1500

auuggcggca agcaagcgcu cgaaagcauu guggcccagc ugagccggcc ugauccggcg     1560

uuggccgcgu ugaccaacga ccaccucguc gccuuggccu gccucggcgg acguccugcc     1620

auggaugcag ugaaaaaggg auugccgcac gcgccggaau ugaucagaag agucaaucgc     1680

cguauuggcg aacgcacguc ccaucgcguu gcgauaucua gagugggagg aagcucgcgc     1740

agagagucca ucaacccaug gauucugacu gguuucgcug augccgaagg aucauucaua     1800

cuagacaucc gcaaccgaaa caacgaaagc aacagauacc gaacuucgcu gagauuccag     1860

aucacccugc acaacaagga caaaucgauu cuggagaaua uccagucgac uuggaagguc     1920

ggcaagauca caaacagcgg cgacagagcc gucaugcuga gggucacccg uuucgaagau     1980

uugaaaguga uuaucgacca cuucgagaaa uauccgcuga uuacccagaa auugggcgau     2040

uacaaguugu uuaaacaggc auucagcguc auggagaaca aagaacaucu uaaggagaau     2100

gggauuaagg agcucguacg aaucaaagcu aagaugaauu ggggucucac ugacgaauug     2160

aaaaaagcau uuccagagaa cauuagcaaa gagcgccccc uuaucaauaa gaacauuccg     2220

aauuucaaau ggcuggcugg auucacaucu ggugauggcu acuucggcgu gaaucuaaaa     2280

aagguaaagg gcaacgcaaa gguauacgug ggacugagau ucucaaucuc acagcacauc     2340

agagacaaga accugaugaa uucauugaua acauaccuag gcugugguuc caucugggag     2400

aagaacaagu cugaguucag uuggcucgag uucgucguaa ccaaauucag cgauaucaac     2460

gacaagauca uuccgguauu ccaggaaaau acucugauug gcgucaaacu cgaggacuuu     2520

gaagauuggu gcaagguugc caaauugauc gaagagaaga aacaccugac cgaauccggu     2580

uuggaugaga uuaagaaaau caagcugaac augaacaaag gucgugucuu cuga           2634


<210>  14
<211>  2634
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthesized megaTAL construct

<400>  14
augggauccg cgccaccuaa gaagaaacgc aaagucgugg aucuacgcac gcucggcuac       60

agucagcagc agcaagagaa gaucaaaccg aaggugcguu cgacaguggc gcagcaccac      120

gaggcacugg ugggccaugg guuuacacac gcgcacaucg uugcgcucag ccaacacccg      180

gcagcguuag ggaccgucgc ugucacguau cagcacauaa ucacggcguu gccagaggcg      240

acacacgaag acaucguugg cgucggcaaa cagugguccg gcgcacgcgc ccuggaggcc      300

uugcucacgg augcggggga guugagaggu ccgccguuac aguuggacac aggccaacuu      360

gugaagauug caaaacgugg cggcgugacc gcaauggagg cagugcaugc aucgcgcaau      420

gcacugacgg gugccccccu gaaccugacc ccggaccaag ugguggcuau cgccagcaac      480

auuggcggca agcaagcgcu cgaaacggug cagcggcugu ugccggugcu gugccaggac      540

cauggccuga ccccggacca agugguggcu aucgccagca acauuggcgg caagcaagcg      600

cucgaaacgg ugcagcggcu guugccggug cugugccagg accauggccu gaccccggac      660

caaguggugg cuaucgccag caacauuggc ggcaagcaag cgcucgaaac ggugcagcgg      720

cuguugccgg ugcugugcca ggaccauggc cugaccccgg accaaguggu ggcuaucgcc      780

agcaacggug gcggcaagca agcgcucgaa acggugcagc ggcuguugcc ggugcugugc      840

caggaccaug gccugacucc ggaccaagug guggcuaucg ccagccacga uggcggcaag      900

caagcgcucg aaacggugca gcggcuguug ccggugcugu gccaggacca uggccugacu      960

ccggaccaag ugguggcuau cgccagccac gauggcggca agcaagcgcu cgaaacggug     1020

cagcggcugu ugccggugcu gugccaggac cauggccuga ccccggacca agugguggcu     1080

aucgccagca acauuggcgg caagcaagcg cucgaaacgg ugcagcggcu guugccggug     1140

cugugccagg accauggccu gaccccggac caaguggugg cuaucgccag caacaauggc     1200

ggcaagcaag cgcucgaaac ggugcagcgg cuguugccgg ugcugugcca ggaccauggc     1260

cugaccccgg accaaguggu ggcuaucgcc agcaacggug gcggcaagca agcgcucgaa     1320

acggugcagc ggcuguugcc ggugcugugc caggaccaug gccugacccc ggaccaagug     1380

guggcuaucg ccagcaacaa uggcggcaag caagcgcucg aaacggugca gcggcuguug     1440

ccggugcugu gccaggacca uggccugacc ccggaccaag ugguggcuau cgccagcaac     1500

auuggcggca agcaagcgcu cgaaagcauu guggcccagc ugagccggcc ugauccggcg     1560

uuggccgcgu ugaccaacga ccaccucguc gccuuggccu gccucggcgg acguccugcc     1620

auggaugcag ugaaaaaggg auugccgcac gcgccggaau ugaucagaag agucaaucgc     1680

cguauuggcg aacgcacguc ccaucgcguu gcgauaucua gagugggagg aagcucgcgc     1740

agagagucca ucaacccaug gauucugacu gguuucgcug augccgaagg aucauucaua     1800

cuagacaucc gcaaccgaaa caacgaaagc aacagauacc gaacuucgcu gagauuccag     1860

aucacccugc acaacaagga caaaucgauu cuggagaaua uccaguccac uuggaagguc     1920

ggcaagauca caaacagcag ugacagagcc gucaugcuga gggucacccg uuucgaagau     1980

uugaaaguga uuaucgacca cuucgagaaa uauccgcuga uuacccagaa auugggcgau     2040

uacaaguugu uuaaacaggc auucagcguc auggagaaua aagaacaucu uaaggagaau     2100

gggauuaagg agcucguacg aaucaaagcu aagaugaauu ggggucucaa ugacgaauug     2160

aaaaaagcau uuccagagaa cauuagcaaa gagcgccccc uuaucaauaa gaacauuccg     2220

aauuucaaau ggcuggcugg auucacagcu ggugaaggcc auuucggcgu gaaucuaaaa     2280

aagguaaagg gcaccgcaaa gguauacgug ggacugagau ucgcuaucuc acagcacauc     2340

agagacaaga accugaugaa uucauugaua acauaccuag gcugugguuc caucagagag     2400

aagaacaagu cugaguucag auggcucgag uucgaaguaa ccaaauucag cgauaucaac     2460

gacaagauca uuccgguauu ccaggaaaau acucugauug gcgucaaacu cgaggacuuu     2520

gaagauuggu gcaagguugc caaauugauc gaagagaaga aacaccugac cgaauccggu     2580

uuggaugaga uuaagaaaau caagcugaac augaacaaag gucgugucuu cuga           2634


<210>  15
<211>  2628
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthesized megaTAL construct

<400>  15
augggauccg cgccaccuaa gaagaaacgc aaagucgugg aucuacgcac gcucggcuac       60

agucagcagc agcaagagaa gaucaaaccg aaggugcguu cgacaguggc gcagcaccac      120

gaggcacugg ugggccaugg guuuacacac gcgcacaucg uugcgcucag ccaacacccg      180

gcagcguuag ggaccgucgc ugucacguau cagcacauaa ucacggcguu gccagaggcg      240

acacacgaag acaucguugg cgucggcaaa cagugguccg gcgcacgcgc ccuggaggcc      300

uugcucacgg augcggggga guugagaggu ccgccguuac aguuggacac aggccaacuu      360

gugaagauug caaaacgugg cggcgugacc gcaauggagg cagugcaugc aucgcgcaau      420

gcacugacgg gugccccccu gaaccugacc ccggaccaag ugguggcuau cgccagcaac      480

auuggcggca agcaagcgcu cgaaacggug cagcggcugu ugccggugcu gugccaggac      540

cauggccuga ccccggacca agugguggcu aucgccagca acauuggcgg caagcaagcg      600

cucgaaacgg ugcagcggcu guugccggug cugugccagg accauggccu gaccccggac      660

caaguggugg cuaucgccag caacauuggc ggcaagcaag cgcucgaaac ggugcagcgg      720

cuguugccgg ugcugugcca ggaccauggc cugaccccgg accaaguggu ggcuaucgcc      780

agcaacggug gcggcaagca agcgcucgaa acggugcagc ggcuguugcc ggugcugugc      840

caggaccaug gccugacucc ggaccaagug guggcuaucg ccagccacga uggcggcaag      900

caagcgcucg aaacggugca gcggcuguug ccggugcugu gccaggacca uggccugacu      960

ccggaccaag ugguggcuau cgccagccac gauggcggca agcaagcgcu cgaaacggug     1020

cagcggcugu ugccggugcu gugccaggac cauggccuga ccccggacca agugguggcu     1080

aucgccagca acauuggcgg caagcaagcg cucgaaacgg ugcagcggcu guugccggug     1140

cugugccagg accauggccu gaccccggac caaguggugg cuaucgccag caacaauggc     1200

ggcaagcaag cgcucgaaac ggugcagcgg cuguugccgg ugcugugcca ggaccauggc     1260

cugaccccgg accaaguggu ggcuaucgcc agcaacggug gcggcaagca agcgcucgaa     1320

acggugcagc ggcuguugcc ggugcugugc caggaccaug gccugacccc ggaccaagug     1380

guggcuaucg ccagcaacaa uggcggcaag caagcgcucg aaacggugca gcggcuguug     1440

ccggugcugu gccaggacca uggccugacc ccggaccaag ugguggcuau cgccagcaac     1500

auuggcggca agcaagcgcu cgaaagcauu guggcccagc ugagccggcc ugauccggcg     1560

uuggccgcgu ugaccaacga ccaccucguc gccuuggccu gccucggcgg acguccugcc     1620

auggaugcag ugaaaaaggg auugccgcac gcgccggaau ugaucagaag agucaaucgc     1680

cguauuggcg aacgcacguc ccaucgcguu gcgauaucua gagugggagg aagcucgcgc     1740

agagagucca ucaacccaug gauucugacu gguuucgcug augccgaagg aucauucaua     1800

cuagacaucc gcaaccgaaa caacgaaagc aacagauacc gaacuucgcu gagauuccag     1860

aucacccugc acaacaagga caaaucgauu cuggagaaua uccaguccac uuggaagguc     1920

ggcaagauca caaacagcag ugacagagcc gucaugcuga gggucacccg uuucgaagau     1980

uugaaaguga uuaucgacca cuucgagaaa uauccgcuga uuacccagaa auugggcgau     2040

uacaaguugu uuaaacaggc auucagcguc auggagaaua aagaacaucu uaaggagaau     2100

gggauuaagg agcucguacg aaucaaagcu aagaugaauu ggggucucaa ugacgaauug     2160

aaaaaagcau uuccagagaa cauuagcaaa gagcgccccc uuaucaauaa gaacauuccg     2220

aauuucaaau ggcuggcugg auucacagcu ggugauggcc auuucggcgu gaaucuaaaa     2280

aagguaaagg gcaccgcaaa gguauacgug ggacugagau ucgcuaucuc acagcacauc     2340

agagacaaga accugaugaa uucauugaua acauaccuag gcugugguuc caucagagag     2400

aagaacaagu cugaguucag auggcucgag uucgaaguaa ccaaauucag cgauaucaac     2460

gacaagauca uuccgguauu ccaggaaaau acucugauug gcgucaaacu cgaggacuuu     2520

gaagauuggu gcaagguugc caaauugauc gaagagaaga aacaccugac cgaauccggu     2580

uuggaugaga uuaagaaaau caagcugaac augaacaaag gucguuga                  2628


<210>  16
<211>  2733
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthesized megaTAL construct

<400>  16
augggauccg ccccuccgaa gaagaagcgg aaagucgugg accuccggac ccuggguuac       60

ucucagcagc agcaggagaa gaucaagccg aaggugcggu cgacuguggc ccagcaucac      120

gaggcccugg ugggacacgg cuucacccac gcccacauug uggcccugag ccagcacccg      180

gcagcgcugg gaaccguggc cgugaccuac cagcacauca uuacugcccu gccugaagcg      240

acccacgagg auaucguggg cgucggaaag cagugguccg gagccagagc cuuggaggcu      300

cugcugacug acgccggaga gcugcggggc ccgccccugc aacuggauac cggccagcuc      360

gugaaaaucg ccaagagagg aggagugacc gccauggaag ccgugcaugc aucccgcaau      420

gcacugacug gugcaccccu gaaccucacu ccugaccagg ucgucgcuau cgcaagcaac      480

aucggaggga aacaagcucu cgagacagug cagcgccucc ugccagugcu uugccaggac      540

cacggccuga cuccagacca gguggucgcu auugcgucga acauuggagg gaagcaagcc      600

cuugaaaccg ugcagaggcu gcucccggug cugugccaag accauggacu caccccggac      660

caaguggugg cuauugcuag caacauuggc gguaagcagg cgcuggagac aguccagcgg      720

cugcugccgg uguugugcca agaucacggu cuuaccccag accaagucgu ggcgauugcc      780

uccaacggug gcggcaagca agcacucgaa acuguccaga gacugcuccc ugugcucugu      840

caagaccacg gguugacccc cgaccaagug guggccaucg ccucccauga uggaggaaag      900

caggcccucg agacugucca gcgacugcuc cccguguugu gucaggauca uggauugacg      960

cccgaucagg ucguggccau ugccucccac gacgguggaa agcaagcgcu ggaaacugug     1020

cagcgguugc ugccgguccu gugccaggac cacggacuga cuccggacca gguggucgcc     1080

aucgcaucca acauuggugg caagcaggcu cucgaaaccg uccaacgccu guugccggug     1140

cugugucagg aucauggacu gaccccggac caaguggugg cuaucgccuc caacaacggg     1200

ggcaaacagg cccuggaaac cgugcaacgc cugcugcccg uccucugcca ggaccacggu     1260

cugaccccug accaggucgu cgcgaucgcg ucaaaugggg ggggcaaaca ggcucuggaa     1320

acggugcagc ggcuccuucc gguguuaugc caggaccacg ggcugacucc cgaccaggug     1380

guggcgaucg ccucgaacaa cggaggcaaa caagcccugg agacugugca gagacuccug     1440

cccgugcugu gccaagacca ugggcucacc ccugaucagg ugguggcaau cgccucaaac     1500

aucggcggga agcaggcacu ggaaacugug cagagacucc ugcccgugcu gugccaagac     1560

caugggcuga ccccggacca agugguggcu aucgccuccc acgacggggg caaacaggcc     1620

cuggaaucca ucgucgcuca gcugagccgg ccugacccag cacucgccgc ccugaccaau     1680

gaccaucugg ucgcccuggc cugccuggga ggcagacccg cgauggacgc ggucaagaag     1740

ggucugccgc acgccccuga gcuuauucgg agagugaaca ggcgcaucgg ugaacgcacc     1800

ucccaucggg ucgcaaucuc uagagugggc ggaucguccc ggcgggaguc caucaauccu     1860

uggauccuga ccggcuucgc cgacgccgaa ggcuccuuca uccuggacau caggaacagg     1920

aacaacgagu caaacaggua ccgcaccucc cuucgguucc agauuacucu gcacaacaag     1980

gauaagucca uccucgagaa cauccaguca accuggaaag ugggcaagau cacuaacucc     2040

ucggaccgcg cagugaugcu ccgggugacc cgcuucgagg accugaaggu gaucauugac     2100

cacuucgaga aguacccucu cauaacccag aagcugggag auuacaagcu guuuaagcag     2160

gcguucuccg ugauggagaa caaagaacac cuuaaggaga augggauuaa ggaacugguc     2220

cgcauuaagg ccaagaugaa cuggggacug aacgacgagu ugaaaaaggc auuuccugaa     2280

aacaucucca aggaacggcc gcucaucaac aagaacauuc ccaauuucaa guggcuggcg     2340

ggguucacug ccggggacgg acacuucgga gugaaccuga agaaggugaa gggcaccgcc     2400

aagguguacg ugggccugcg guucgcgauc agccagcaca uccgggauaa gaaccugaug     2460

aacagccuca ucaccuaccu gggaugcgga agcauccggg agaagaacaa gucagaauuc     2520

cgauggcugg aauuugaagu gaccaaguuc uccgacauca acgacaagau cauccccgug     2580

uuccaggaga acacccucau uggagugaag cuggaggacu ucgaggacug gugcaaggug     2640

gccaagcuca ucgaagagaa gaagcaccug accgaaagcg gccuggauga gauuaagaag     2700

auuaagcuca acaugaacaa gggaagauag uag                                  2733


<210>  17
<211>  22
<212>  DNA
<213>  Homo sapiens

<400>  17
tgtctgccta ttcaccgatt tt                                                22


<210>  18
<211>  11
<212>  DNA
<213>  Homo sapiens

<400>  18
aaatccagtg a                                                            11


<210>  19
<211>  12
<212>  DNA
<213>  Homo sapiens

<400>  19
aaatccagtg ac                                                           12


<210>  20
<211>  39
<212>  DNA
<213>  Homo sapiens

<400>  20
aaatccagtg acaagtctgt ctgcctattc accgatttt                              39


<210>  21
<211>  22
<212>  DNA
<213>  Homo sapiens

<400>  21
agtatgccta ttctacaaga aa                                                22


<210>  22
<211>  877
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized NTD variant megaTAL construct

<400>  22

Met Gly Ser Ala Pro Pro Lys Lys Lys Arg Lys Val Gly Lys Leu Cys 
1               5                   10                  15      


Thr Leu Gly Tyr Ser Gln Gln Gln Gln Glu Lys Leu Lys Leu Lys Ala 
            20                  25                  30          


Arg Pro Ile Val Ala Gln His His Glu Ala Leu Ile Gly His Gly Phe 
        35                  40                  45              


Thr Arg Ala Gln Ile Val Ala Leu Ser Gln His Pro Ala Ala Leu Gly 
    50                  55                  60                  


Thr Ile Ala Ala Lys Tyr Gln Ala Met Ile Ala Ala Leu Pro Glu Ala 
65                  70                  75                  80  


Thr His Glu Asp Val Val Gly Ile Gly Lys Gln Trp Ser Gly Ala Arg 
                85                  90                  95      


Thr Leu Glu Val Leu Leu Thr Val Ser Gly Glu Leu Arg Ser Pro Pro 
            100                 105                 110         


Leu Gln Leu Asp Thr Ser Gln Leu Leu Lys Ile Ala Lys Arg Gly Gly 
        115                 120                 125             


Val Thr Ala Ile Glu Ala Val His Ala Trp Arg Asn Ala Leu Thr Gly 
    130                 135                 140                 


Ala Pro Leu Asn Leu Thr Pro Asp Gln Val Val Ala Ile Ala Ser Asn 
145                 150                 155                 160 


Ile Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu Leu Pro Val 
                165                 170                 175     


Leu Cys Gln Asp His Gly Leu Thr Pro Asp Gln Val Val Ala Ile Ala 
            180                 185                 190         


Ser Asn Ile Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu Leu 
        195                 200                 205             


Pro Val Leu Cys Gln Asp His Gly Leu Thr Pro Asp Gln Val Val Ala 
    210                 215                 220                 


Ile Ala Ser Asn Ile Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg 
225                 230                 235                 240 


Leu Leu Pro Val Leu Cys Gln Asp His Gly Leu Thr Pro Asp Gln Val 
                245                 250                 255     


Val Ala Ile Ala Ser Asn Gly Gly Gly Lys Gln Ala Leu Glu Thr Val 
            260                 265                 270         


Gln Arg Leu Leu Pro Val Leu Cys Gln Asp His Gly Leu Thr Pro Asp 
        275                 280                 285             


Gln Val Val Ala Ile Ala Ser His Asp Gly Gly Lys Gln Ala Leu Glu 
    290                 295                 300                 


Thr Val Gln Arg Leu Leu Pro Val Leu Cys Gln Asp His Gly Leu Thr 
305                 310                 315                 320 


Pro Asp Gln Val Val Ala Ile Ala Ser His Asp Gly Gly Lys Gln Ala 
                325                 330                 335     


Leu Glu Thr Val Gln Arg Leu Leu Pro Val Leu Cys Gln Asp His Gly 
            340                 345                 350         


Leu Thr Pro Asp Gln Val Val Ala Ile Ala Ser Asn Ile Gly Gly Lys 
        355                 360                 365             


Gln Ala Leu Glu Thr Val Gln Arg Leu Leu Pro Val Leu Cys Gln Asp 
    370                 375                 380                 


His Gly Leu Thr Pro Asp Gln Val Val Ala Ile Ala Ser Asn Asn Gly 
385                 390                 395                 400 


Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu Leu Pro Val Leu Cys 
                405                 410                 415     


Gln Asp His Gly Leu Thr Pro Asp Gln Val Val Ala Ile Ala Ser Asn 
            420                 425                 430         


Gly Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu Leu Pro Val 
        435                 440                 445             


Leu Cys Gln Asp His Gly Leu Thr Pro Asp Gln Val Val Ala Ile Ala 
    450                 455                 460                 


Ser Asn Asn Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu Leu 
465                 470                 475                 480 


Pro Val Leu Cys Gln Asp His Gly Leu Thr Pro Asp Gln Val Val Ala 
                485                 490                 495     


Ile Ala Ser Asn Ile Gly Gly Lys Gln Ala Leu Glu Ser Ile Val Ala 
            500                 505                 510         


Gln Leu Ser Arg Pro Asp Pro Ala Leu Ala Ala Leu Thr Asn Asp His 
        515                 520                 525             


Leu Val Ala Leu Ala Cys Leu Gly Gly Arg Pro Ala Met Asp Ala Val 
    530                 535                 540                 


Lys Lys Gly Leu Pro His Ala Pro Glu Leu Ile Arg Arg Val Asn Arg 
545                 550                 555                 560 


Arg Ile Gly Glu Arg Thr Ser His Arg Val Ala Ile Ser Arg Val Gly 
                565                 570                 575     


Gly Ser Ser Arg Arg Glu Ser Ile Asn Pro Trp Ile Leu Thr Gly Phe 
            580                 585                 590         


Ala Asp Ala Glu Gly Ser Phe Ile Leu Asp Ile Arg Asn Arg Asn Asn 
        595                 600                 605             


Glu Ser Asn Arg Tyr Arg Thr Ser Leu Arg Phe Gln Ile Thr Leu His 
    610                 615                 620                 


Asn Lys Asp Lys Ser Ile Leu Glu Asn Ile Gln Ser Thr Trp Lys Val 
625                 630                 635                 640 


Gly Lys Ile Thr Asn Ser Gly Asp Arg Ala Val Met Leu Arg Val Thr 
                645                 650                 655     


Arg Phe Glu Asp Leu Lys Val Ile Ile Asp His Phe Glu Lys Tyr Pro 
            660                 665                 670         


Leu Ile Thr Gln Lys Leu Gly Asp Tyr Lys Leu Phe Lys Gln Ala Phe 
        675                 680                 685             


Ser Val Met Glu Asn Lys Glu His Leu Lys Glu Asn Gly Ile Lys Glu 
    690                 695                 700                 


Leu Val Arg Ile Lys Ala Lys Met Asn Trp Gly Leu Thr Asp Glu Leu 
705                 710                 715                 720 


Lys Lys Ala Phe Pro Glu Asn Ile Ser Lys Glu Arg Pro Leu Ile Asn 
                725                 730                 735     


Lys Asn Ile Pro Asn Phe Lys Trp Leu Ala Gly Phe Thr Ser Gly Asp 
            740                 745                 750         


Gly Tyr Phe Gly Val Asn Leu Lys Lys Val Lys Gly Asn Ala Lys Val 
        755                 760                 765             


Tyr Val Gly Leu Arg Phe Ser Ile Ser Gln His Ile Arg Asp Lys Asn 
    770                 775                 780                 


Leu Met Asn Ser Leu Ile Thr Tyr Leu Gly Cys Gly Ser Ile Trp Glu 
785                 790                 795                 800 


Lys Asn Lys Ser Glu Phe Ser Trp Leu Glu Phe Val Val Thr Lys Phe 
                805                 810                 815     


Ser Asp Ile Asn Asp Lys Ile Ile Pro Val Phe Gln Glu Asn Thr Leu 
            820                 825                 830         


Ile Gly Val Lys Leu Glu Asp Phe Glu Asp Trp Cys Lys Val Ala Lys 
        835                 840                 845             


Leu Ile Glu Glu Lys Lys His Leu Thr Glu Ser Gly Leu Asp Glu Ile 
    850                 855                 860                 


Lys Lys Ile Lys Leu Asn Met Asn Lys Gly Arg Val Phe 
865                 870                 875         


<210>  23
<211>  877
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized NTD variant megaTAL construct

<400>  23

Met Gly Ser Ala Pro Pro Lys Lys Lys Arg Lys Val Val Asp Leu Ser 
1               5                   10                  15      


Thr Phe Gly Tyr Ser Gln Gln Gln Gln Glu Lys Ile Lys Pro Lys Val 
            20                  25                  30          


Arg Ser Thr Val Ala Gln His His Ala Ala Leu Val Gly His Gly Phe 
        35                  40                  45              


Thr His Ala His Ile Val Glu Leu Ser Lys His Pro Pro Ala Leu Gly 
    50                  55                  60                  


Thr Ile Ala Ala Arg Tyr Ser Glu Met Ile Ala Ala Leu Pro Glu Ala 
65                  70                  75                  80  


Thr His Glu Asp Ile Val Gly Val Gly Lys His Cys Ala Gly Ala Arg 
                85                  90                  95      


Thr Leu Glu Val Leu Leu Met Val Val Gln Glu Leu Arg Ala Pro Pro 
            100                 105                 110         


Leu Gln Leu Val Thr Ser Gln Leu Leu Lys Ile Ala Lys Arg Gly Gly 
        115                 120                 125             


Val Thr Ala Val Glu Ala Val His Ala Ser Arg Asn Ala Leu Thr Gly 
    130                 135                 140                 


Ala Pro Leu Asn Leu Thr Pro Asp Gln Val Val Ala Ile Ala Ser Asn 
145                 150                 155                 160 


Ile Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu Leu Pro Val 
                165                 170                 175     


Leu Cys Gln Asp His Gly Leu Thr Pro Asp Gln Val Val Ala Ile Ala 
            180                 185                 190         


Ser Asn Ile Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu Leu 
        195                 200                 205             


Pro Val Leu Cys Gln Asp His Gly Leu Thr Pro Asp Gln Val Val Ala 
    210                 215                 220                 


Ile Ala Ser Asn Ile Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg 
225                 230                 235                 240 


Leu Leu Pro Val Leu Cys Gln Asp His Gly Leu Thr Pro Asp Gln Val 
                245                 250                 255     


Val Ala Ile Ala Ser Asn Gly Gly Gly Lys Gln Ala Leu Glu Thr Val 
            260                 265                 270         


Gln Arg Leu Leu Pro Val Leu Cys Gln Asp His Gly Leu Thr Pro Asp 
        275                 280                 285             


Gln Val Val Ala Ile Ala Ser His Asp Gly Gly Lys Gln Ala Leu Glu 
    290                 295                 300                 


Thr Val Gln Arg Leu Leu Pro Val Leu Cys Gln Asp His Gly Leu Thr 
305                 310                 315                 320 


Pro Asp Gln Val Val Ala Ile Ala Ser His Asp Gly Gly Lys Gln Ala 
                325                 330                 335     


Leu Glu Thr Val Gln Arg Leu Leu Pro Val Leu Cys Gln Asp His Gly 
            340                 345                 350         


Leu Thr Pro Asp Gln Val Val Ala Ile Ala Ser Asn Ile Gly Gly Lys 
        355                 360                 365             


Gln Ala Leu Glu Thr Val Gln Arg Leu Leu Pro Val Leu Cys Gln Asp 
    370                 375                 380                 


His Gly Leu Thr Pro Asp Gln Val Val Ala Ile Ala Ser Asn Asn Gly 
385                 390                 395                 400 


Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu Leu Pro Val Leu Cys 
                405                 410                 415     


Gln Asp His Gly Leu Thr Pro Asp Gln Val Val Ala Ile Ala Ser Asn 
            420                 425                 430         


Gly Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu Leu Pro Val 
        435                 440                 445             


Leu Cys Gln Asp His Gly Leu Thr Pro Asp Gln Val Val Ala Ile Ala 
    450                 455                 460                 


Ser Asn Asn Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu Leu 
465                 470                 475                 480 


Pro Val Leu Cys Gln Asp His Gly Leu Thr Pro Asp Gln Val Val Ala 
                485                 490                 495     


Ile Ala Ser Asn Ile Gly Gly Lys Gln Ala Leu Glu Ser Ile Val Ala 
            500                 505                 510         


Gln Leu Ser Arg Pro Asp Pro Ala Leu Ala Ala Leu Thr Asn Asp His 
        515                 520                 525             


Leu Val Ala Leu Ala Cys Leu Gly Gly Arg Pro Ala Met Asp Ala Val 
    530                 535                 540                 


Lys Lys Gly Leu Pro His Ala Pro Glu Leu Ile Arg Arg Val Asn Arg 
545                 550                 555                 560 


Arg Ile Gly Glu Arg Thr Ser His Arg Val Ala Ile Ser Arg Val Gly 
                565                 570                 575     


Gly Ser Ser Arg Arg Glu Ser Ile Asn Pro Trp Ile Leu Thr Gly Phe 
            580                 585                 590         


Ala Asp Ala Glu Gly Ser Phe Ile Leu Asp Ile Arg Asn Arg Asn Asn 
        595                 600                 605             


Glu Ser Asn Arg Tyr Arg Thr Ser Leu Arg Phe Gln Ile Thr Leu His 
    610                 615                 620                 


Asn Lys Asp Lys Ser Ile Leu Glu Asn Ile Gln Ser Thr Trp Lys Val 
625                 630                 635                 640 


Gly Lys Ile Thr Asn Ser Gly Asp Arg Ala Val Met Leu Arg Val Thr 
                645                 650                 655     


Arg Phe Glu Asp Leu Lys Val Ile Ile Asp His Phe Glu Lys Tyr Pro 
            660                 665                 670         


Leu Ile Thr Gln Lys Leu Gly Asp Tyr Lys Leu Phe Lys Gln Ala Phe 
        675                 680                 685             


Ser Val Met Glu Asn Lys Glu His Leu Lys Glu Asn Gly Ile Lys Glu 
    690                 695                 700                 


Leu Val Arg Ile Lys Ala Lys Met Asn Trp Gly Leu Thr Asp Glu Leu 
705                 710                 715                 720 


Lys Lys Ala Phe Pro Glu Asn Ile Ser Lys Glu Arg Pro Leu Ile Asn 
                725                 730                 735     


Lys Asn Ile Pro Asn Phe Lys Trp Leu Ala Gly Phe Thr Ser Gly Asp 
            740                 745                 750         


Gly Tyr Phe Gly Val Asn Leu Lys Lys Val Lys Gly Asn Ala Lys Val 
        755                 760                 765             


Tyr Val Gly Leu Arg Phe Ser Ile Ser Gln His Ile Arg Asp Lys Asn 
    770                 775                 780                 


Leu Met Asn Ser Leu Ile Thr Tyr Leu Gly Cys Gly Ser Ile Trp Glu 
785                 790                 795                 800 


Lys Asn Lys Ser Glu Phe Ser Trp Leu Glu Phe Val Val Thr Lys Phe 
                805                 810                 815     


Ser Asp Ile Asn Asp Lys Ile Ile Pro Val Phe Gln Glu Asn Thr Leu 
            820                 825                 830         


Ile Gly Val Lys Leu Glu Asp Phe Glu Asp Trp Cys Lys Val Ala Lys 
        835                 840                 845             


Leu Ile Glu Glu Lys Lys His Leu Thr Glu Ser Gly Leu Asp Glu Ile 
    850                 855                 860                 


Lys Lys Ile Lys Leu Asn Met Asn Lys Gly Arg Val Phe 
865                 870                 875         


<210>  24
<211>  877
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized NTD variant megaTAL construct

<400>  24

Met Gly Ser Ala Pro Pro Lys Lys Lys Arg Lys Val Gly Lys Leu Ser 
1               5                   10                  15      


Thr Phe Gly Tyr Ser Gln Gln Gln Gln Glu Lys Ile Lys Pro Lys Ala 
            20                  25                  30          


Arg Ser Thr Val Ala Gln His His Ala Ala Leu Ile Gly His Gly Phe 
        35                  40                  45              


Thr His Ala His Ile Val Glu Leu Ser Lys His Pro Pro Ala Leu Gly 
    50                  55                  60                  


Thr Ile Ala Ala Arg Tyr Ser Glu Met Ile Ala Ala Leu Pro Glu Ala 
65                  70                  75                  80  


Thr His Glu Asp Ile Val Gly Val Gly Lys Gln Trp Ser Gly Ala Arg 
                85                  90                  95      


Thr Leu Glu Val Leu Leu Met Val Val Gln Glu Leu Arg Ala Pro Pro 
            100                 105                 110         


Leu Gln Leu Val Thr Ser Gln Leu Val Lys Ile Ala Lys Arg Gly Gly 
        115                 120                 125             


Val Thr Ala Ile Glu Ala Val His Ala Ser Arg Asn Ala Leu Thr Gly 
    130                 135                 140                 


Ala Pro Leu Asn Leu Thr Pro Asp Gln Val Val Ala Ile Ala Ser Asn 
145                 150                 155                 160 


Ile Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu Leu Pro Val 
                165                 170                 175     


Leu Cys Gln Asp His Gly Leu Thr Pro Asp Gln Val Val Ala Ile Ala 
            180                 185                 190         


Ser Asn Ile Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu Leu 
        195                 200                 205             


Pro Val Leu Cys Gln Asp His Gly Leu Thr Pro Asp Gln Val Val Ala 
    210                 215                 220                 


Ile Ala Ser Asn Ile Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg 
225                 230                 235                 240 


Leu Leu Pro Val Leu Cys Gln Asp His Gly Leu Thr Pro Asp Gln Val 
                245                 250                 255     


Val Ala Ile Ala Ser Asn Gly Gly Gly Lys Gln Ala Leu Glu Thr Val 
            260                 265                 270         


Gln Arg Leu Leu Pro Val Leu Cys Gln Asp His Gly Leu Thr Pro Asp 
        275                 280                 285             


Gln Val Val Ala Ile Ala Ser His Asp Gly Gly Lys Gln Ala Leu Glu 
    290                 295                 300                 


Thr Val Gln Arg Leu Leu Pro Val Leu Cys Gln Asp His Gly Leu Thr 
305                 310                 315                 320 


Pro Asp Gln Val Val Ala Ile Ala Ser His Asp Gly Gly Lys Gln Ala 
                325                 330                 335     


Leu Glu Thr Val Gln Arg Leu Leu Pro Val Leu Cys Gln Asp His Gly 
            340                 345                 350         


Leu Thr Pro Asp Gln Val Val Ala Ile Ala Ser Asn Ile Gly Gly Lys 
        355                 360                 365             


Gln Ala Leu Glu Thr Val Gln Arg Leu Leu Pro Val Leu Cys Gln Asp 
    370                 375                 380                 


His Gly Leu Thr Pro Asp Gln Val Val Ala Ile Ala Ser Asn Asn Gly 
385                 390                 395                 400 


Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu Leu Pro Val Leu Cys 
                405                 410                 415     


Gln Asp His Gly Leu Thr Pro Asp Gln Val Val Ala Ile Ala Ser Asn 
            420                 425                 430         


Gly Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu Leu Pro Val 
        435                 440                 445             


Leu Cys Gln Asp His Gly Leu Thr Pro Asp Gln Val Val Ala Ile Ala 
    450                 455                 460                 


Ser Asn Asn Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu Leu 
465                 470                 475                 480 


Pro Val Leu Cys Gln Asp His Gly Leu Thr Pro Asp Gln Val Val Ala 
                485                 490                 495     


Ile Ala Ser Asn Ile Gly Gly Lys Gln Ala Leu Glu Ser Ile Val Ala 
            500                 505                 510         


Gln Leu Ser Arg Pro Asp Pro Ala Leu Ala Ala Leu Thr Asn Asp His 
        515                 520                 525             


Leu Val Ala Leu Ala Cys Leu Gly Gly Arg Pro Ala Met Asp Ala Val 
    530                 535                 540                 


Lys Lys Gly Leu Pro His Ala Pro Glu Leu Ile Arg Arg Val Asn Arg 
545                 550                 555                 560 


Arg Ile Gly Glu Arg Thr Ser His Arg Val Ala Ile Ser Arg Val Gly 
                565                 570                 575     


Gly Ser Ser Arg Arg Glu Ser Ile Asn Pro Trp Ile Leu Thr Gly Phe 
            580                 585                 590         


Ala Asp Ala Glu Gly Ser Phe Ile Leu Asp Ile Arg Asn Arg Asn Asn 
        595                 600                 605             


Glu Ser Asn Arg Tyr Arg Thr Ser Leu Arg Phe Gln Ile Thr Leu His 
    610                 615                 620                 


Asn Lys Asp Lys Ser Ile Leu Glu Asn Ile Gln Ser Thr Trp Lys Val 
625                 630                 635                 640 


Gly Lys Ile Thr Asn Ser Gly Asp Arg Ala Val Met Leu Arg Val Thr 
                645                 650                 655     


Arg Phe Glu Asp Leu Lys Val Ile Ile Asp His Phe Glu Lys Tyr Pro 
            660                 665                 670         


Leu Ile Thr Gln Lys Leu Gly Asp Tyr Lys Leu Phe Lys Gln Ala Phe 
        675                 680                 685             


Ser Val Met Glu Asn Lys Glu His Leu Lys Glu Asn Gly Ile Lys Glu 
    690                 695                 700                 


Leu Val Arg Ile Lys Ala Lys Met Asn Trp Gly Leu Thr Asp Glu Leu 
705                 710                 715                 720 


Lys Lys Ala Phe Pro Glu Asn Ile Ser Lys Glu Arg Pro Leu Ile Asn 
                725                 730                 735     


Lys Asn Ile Pro Asn Phe Lys Trp Leu Ala Gly Phe Thr Ser Gly Asp 
            740                 745                 750         


Gly Tyr Phe Gly Val Asn Leu Lys Lys Val Lys Gly Asn Ala Lys Val 
        755                 760                 765             


Tyr Val Gly Leu Arg Phe Ser Ile Ser Gln His Ile Arg Asp Lys Asn 
    770                 775                 780                 


Leu Met Asn Ser Leu Ile Thr Tyr Leu Gly Cys Gly Ser Ile Trp Glu 
785                 790                 795                 800 


Lys Asn Lys Ser Glu Phe Ser Trp Leu Glu Phe Val Val Thr Lys Phe 
                805                 810                 815     


Ser Asp Ile Asn Asp Lys Ile Ile Pro Val Phe Gln Glu Asn Thr Leu 
            820                 825                 830         


Ile Gly Val Lys Leu Glu Asp Phe Glu Asp Trp Cys Lys Val Ala Lys 
        835                 840                 845             


Leu Ile Glu Glu Lys Lys His Leu Thr Glu Ser Gly Leu Asp Glu Ile 
    850                 855                 860                 


Lys Lys Ile Lys Leu Asn Met Asn Lys Gly Arg Val Phe 
865                 870                 875         


<210>  25
<211>  2634
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthesized NTD variant megaTAL construct

<400>  25
augggauccg cgccaccuaa gaagaaacgc aaagucggca agcugugcac ccugggcuac       60

agccagcagc agcaggagaa gcugaagcug aaggccagac ccaucguggc ccagcaccac      120

gaggcccuga ucggccacgg cuucaccaga gcccagaucg uggcccugag ccagcacccc      180

gccgcccugg gcaccaucgc cgccaaguac caggccauga ucgccgcccu gcccgaggcc      240

acccacgagg acgugguggg caucggcaag caguggagcg gcgccagaac ccuggaggug      300

cuacugaccg ugagcggcga gcugagaagc cccccccugc agcuggacac cagccagcug      360

cugaagaucg ccaagagagg cggcgugacc gccaucgagg ccgugcacgc cuggcgcaau      420

gcacugacgg gugccccccu gaaccugacc ccggaccaag ugguggcuau cgccagcaac      480

auuggcggca agcaagcgcu cgaaacggug cagcggcugu ugccggugcu gugccaggac      540

cauggccuga ccccggacca agugguggcu aucgccagca acauuggcgg caagcaagcg      600

cucgaaacgg ugcagcggcu guugccggug cugugccagg accauggccu gaccccggac      660

caaguggugg cuaucgccag caacauuggc ggcaagcaag cgcucgaaac ggugcagcgg      720

cuguugccgg ugcugugcca ggaccauggc cugaccccgg accaaguggu ggcuaucgcc      780

agcaacggug gcggcaagca agcgcucgaa acggugcagc ggcuguugcc ggugcugugc      840

caggaccaug gccugacucc ggaccaagug guggcuaucg ccagccacga uggcggcaag      900

caagcgcucg aaacggugca gcggcuguug ccggugcugu gccaggacca uggccugacu      960

ccggaccaag ugguggcuau cgccagccac gauggcggca agcaagcgcu cgaaacggug     1020

cagcggcugu ugccggugcu gugccaggac cauggccuga ccccggacca agugguggcu     1080

aucgccagca acauuggcgg caagcaagcg cucgaaacgg ugcagcggcu guugccggug     1140

cugugccagg accauggccu gaccccggac caaguggugg cuaucgccag caacaauggc     1200

ggcaagcaag cgcucgaaac ggugcagcgg cuguugccgg ugcugugcca ggaccauggc     1260

cugaccccgg accaaguggu ggcuaucgcc agcaacggug gcggcaagca agcgcucgaa     1320

acggugcagc ggcuguugcc ggugcugugc caggaccaug gccugacccc ggaccaagug     1380

guggcuaucg ccagcaacaa uggcggcaag caagcgcucg aaacggugca gcggcuguug     1440

ccggugcugu gccaggacca uggccugacc ccggaccaag ugguggcuau cgccagcaac     1500

auuggcggca agcaagcgcu cgaaagcauu guggcccagc ugagccggcc ugauccggcg     1560

uuggccgcgu ugaccaacga ccaccucguc gccuuggccu gccucggcgg acguccugcc     1620

auggaugcag ugaaaaaggg auugccgcac gcgccggaau ugaucagaag agucaaucgc     1680

cguauuggcg aacgcacguc ccaucgcguu gcgauaucua gagugggagg aagcucgcgc     1740

agagagucca ucaacccaug gauucugacu gguuucgcug augccgaagg aucauucaua     1800

cuagacaucc gcaaccgaaa caacgaaagc aacagauacc gaacuucgcu gagauuccag     1860

aucacccugc acaacaagga caaaucgauu cuggagaaua uccagucgac uuggaagguc     1920

ggcaagauca caaacagcgg cgacagagcc gucaugcuga gggucacccg uuucgaagau     1980

uugaaaguga uuaucgacca cuucgagaaa uauccgcuga uuacccagaa auugggcgau     2040

uacaaguugu uuaaacaggc auucagcguc auggagaaca aagaacaucu uaaggagaau     2100

gggauuaagg agcucguacg aaucaaagcu aagaugaauu ggggucucac ugacgaauug     2160

aaaaaagcau uuccagagaa cauuagcaaa gagcgccccc uuaucaauaa gaacauuccg     2220

aauuucaaau ggcuggcugg auucacaucu ggugauggcu acuucggcgu gaaucuaaaa     2280

aagguaaagg gcaacgcaaa gguauacgug ggacugagau ucucaaucuc acagcacauc     2340

agagacaaga accugaugaa uucauugaua acauaccuag gcugugguuc caucugggag     2400

aagaacaagu cugaguucag uuggcucgag uucgucguaa ccaaauucag cgauaucaac     2460

gacaagauca uuccgguauu ccaggaaaau acucugauug gcgucaaacu cgaggacuuu     2520

gaagauuggu gcaagguugc caaauugauc gaagagaaga aacaccugac cgaauccggu     2580

uuggaugaga uuaagaaaau caagcugaac augaacaaag gucgugucuu cuga           2634


<210>  26
<211>  2634
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthesized NTD variant megaTAL construct

<400>  26
augggauccg cgccaccuaa gaagaaacgc aaagucgugg accugagcac cuucggcuac       60

agccagcagc agcaggagaa gaucaagccc aaggugagaa gcaccguggc ccagcaccac      120

gccgcccugg ugggccacgg cuucacccac gcccacaucg uggagcugag caagcacccc      180

cccgcccugg gcaccaucgc cgccagauac agcgagauga ucgccgcccu gcccgaggcc      240

acccacgagg acaucguggg cgugggcaag cacugcgccg gcgccagaac ccuggaggug      300

cugcugaugg uggugcagga gcugagagcu ccaccacugc agcuggugac cagccagcug      360

cugaagaucg ccaagagagg cggcgugacc gccguggagg ccgugcacgc cagccgcaau      420

gcacugacgg gugccccccu gaaccugacc ccggaccaag ugguggcuau cgccagcaac      480

auuggcggca agcaagcgcu cgaaacggug cagcggcugu ugccggugcu gugccaggac      540

cauggccuga ccccggacca agugguggcu aucgccagca acauuggcgg caagcaagcg      600

cucgaaacgg ugcagcggcu guugccggug cugugccagg accauggccu gaccccggac      660

caaguggugg cuaucgccag caacauuggc ggcaagcaag cgcucgaaac ggugcagcgg      720

cuguugccgg ugcugugcca ggaccauggc cugaccccgg accaaguggu ggcuaucgcc      780

agcaacggug gcggcaagca agcgcucgaa acggugcagc ggcuguugcc ggugcugugc      840

caggaccaug gccugacucc ggaccaagug guggcuaucg ccagccacga uggcggcaag      900

caagcgcucg aaacggugca gcggcuguug ccggugcugu gccaggacca uggccugacu      960

ccggaccaag ugguggcuau cgccagccac gauggcggca agcaagcgcu cgaaacggug     1020

cagcggcugu ugccggugcu gugccaggac cauggccuga ccccggacca agugguggcu     1080

aucgccagca acauuggcgg caagcaagcg cucgaaacgg ugcagcggcu guugccggug     1140

cugugccagg accauggccu gaccccggac caaguggugg cuaucgccag caacaauggc     1200

ggcaagcaag cgcucgaaac ggugcagcgg cuguugccgg ugcugugcca ggaccauggc     1260

cugaccccgg accaaguggu ggcuaucgcc agcaacggug gcggcaagca agcgcucgaa     1320

acggugcagc ggcuguugcc ggugcugugc caggaccaug gccugacccc ggaccaagug     1380

guggcuaucg ccagcaacaa uggcggcaag caagcgcucg aaacggugca gcggcuguug     1440

ccggugcugu gccaggacca uggccugacc ccggaccaag ugguggcuau cgccagcaac     1500

auuggcggca agcaagcgcu cgaaagcauu guggcccagc ugagccggcc ugauccggcg     1560

uuggccgcgu ugaccaacga ccaccucguc gccuuggccu gccucggcgg acguccugcc     1620

auggaugcag ugaaaaaggg auugccgcac gcgccggaau ugaucagaag agucaaucgc     1680

cguauuggcg aacgcacguc ccaucgcguu gcgauaucua gagugggagg aagcucgcgc     1740

agagagucca ucaacccaug gauucugacu gguuucgcug augccgaagg aucauucaua     1800

cuagacaucc gcaaccgaaa caacgaaagc aacagauacc gaacuucgcu gagauuccag     1860

aucacccugc acaacaagga caaaucgauu cuggagaaua uccagucgac uuggaagguc     1920

ggcaagauca caaacagcgg cgacagagcc gucaugcuga gggucacccg uuucgaagau     1980

uugaaaguga uuaucgacca cuucgagaaa uauccgcuga uuacccagaa auugggcgau     2040

uacaaguugu uuaaacaggc auucagcguc auggagaaca aagaacaucu uaaggagaau     2100

gggauuaagg agcucguacg aaucaaagcu aagaugaauu ggggucucac ugacgaauug     2160

aaaaaagcau uuccagagaa cauuagcaaa gagcgccccc uuaucaauaa gaacauuccg     2220

aauuucaaau ggcuggcugg auucacaucu ggugauggcu acuucggcgu gaaucuaaaa     2280

aagguaaagg gcaacgcaaa gguauacgug ggacugagau ucucaaucuc acagcacauc     2340

agagacaaga accugaugaa uucauugaua acauaccuag gcugugguuc caucugggag     2400

aagaacaagu cugaguucag uuggcucgag uucgucguaa ccaaauucag cgauaucaac     2460

gacaagauca uuccgguauu ccaggaaaau acucugauug gcgucaaacu cgaggacuuu     2520

gaagauuggu gcaagguugc caaauugauc gaagagaaga aacaccugac cgaauccggu     2580

uuggaugaga uuaagaaaau caagcugaac augaacaaag gucgugucuu cuga           2634


<210>  27
<211>  2634
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthesized NTD variant megaTAL construct

<400>  27
augggauccg cgccaccuaa gaagaaacgc aaagucggca agcugagcac cuucggcuac       60

agccagcagc agcaggagaa gaucaagccc aaggccagaa gcaccguggc ccagcaccac      120

gccgcccuga ucggccacgg cuucacccac gcccacaucg uggagcugag caagcacccc      180

cccgcccugg gcaccaucgc cgccagauac agcgagauga ucgccgcccu gcccgaggcc      240

acccacgagg acaucguggg cgugggcaag caguggagcg gcgccagaac ccuggaggug      300

cugcugaugg uggugcagga gcugagagcu ccaccacugc agcuggugac cagccagcug      360

gugaagaucg ccaagagagg cggcgugacc gccaucgagg ccgugcacgc cagccgcaau      420

gcacugacgg gugccccccu gaaccugacc ccggaccaag ugguggcuau cgccagcaac      480

auuggcggca agcaagcgcu cgaaacggug cagcggcugu ugccggugcu gugccaggac      540

cauggccuga ccccggacca agugguggcu aucgccagca acauuggcgg caagcaagcg      600

cucgaaacgg ugcagcggcu guugccggug cugugccagg accauggccu gaccccggac      660

caaguggugg cuaucgccag caacauuggc ggcaagcaag cgcucgaaac ggugcagcgg      720

cuguugccgg ugcugugcca ggaccauggc cugaccccgg accaaguggu ggcuaucgcc      780

agcaacggug gcggcaagca agcgcucgaa acggugcagc ggcuguugcc ggugcugugc      840

caggaccaug gccugacucc ggaccaagug guggcuaucg ccagccacga uggcggcaag      900

caagcgcucg aaacggugca gcggcuguug ccggugcugu gccaggacca uggccugacu      960

ccggaccaag ugguggcuau cgccagccac gauggcggca agcaagcgcu cgaaacggug     1020

cagcggcugu ugccggugcu gugccaggac cauggccuga ccccggacca agugguggcu     1080

aucgccagca acauuggcgg caagcaagcg cucgaaacgg ugcagcggcu guugccggug     1140

cugugccagg accauggccu gaccccggac caaguggugg cuaucgccag caacaauggc     1200

ggcaagcaag cgcucgaaac ggugcagcgg cuguugccgg ugcugugcca ggaccauggc     1260

cugaccccgg accaaguggu ggcuaucgcc agcaacggug gcggcaagca agcgcucgaa     1320

acggugcagc ggcuguugcc ggugcugugc caggaccaug gccugacccc ggaccaagug     1380

guggcuaucg ccagcaacaa uggcggcaag caagcgcucg aaacggugca gcggcuguug     1440

ccggugcugu gccaggacca uggccugacc ccggaccaag ugguggcuau cgccagcaac     1500

auuggcggca agcaagcgcu cgaaagcauu guggcccagc ugagccggcc ugauccggcg     1560

uuggccgcgu ugaccaacga ccaccucguc gccuuggccu gccucggcgg acguccugcc     1620

auggaugcag ugaaaaaggg auugccgcac gcgccggaau ugaucagaag agucaaucgc     1680

cguauuggcg aacgcacguc ccaucgcguu gcgauaucua gagugggagg aagcucgcgc     1740

agagagucca ucaacccaug gauucugacu gguuucgcug augccgaagg aucauucaua     1800

cuagacaucc gcaaccgaaa caacgaaagc aacagauacc gaacuucgcu gagauuccag     1860

aucacccugc acaacaagga caaaucgauu cuggagaaua uccagucgac uuggaagguc     1920

ggcaagauca caaacagcgg cgacagagcc gucaugcuga gggucacccg uuucgaagau     1980

uugaaaguga uuaucgacca cuucgagaaa uauccgcuga uuacccagaa auugggcgau     2040

uacaaguugu uuaaacaggc auucagcguc auggagaaca aagaacaucu uaaggagaau     2100

gggauuaagg agcucguacg aaucaaagcu aagaugaauu ggggucucac ugacgaauug     2160

aaaaaagcau uuccagagaa cauuagcaaa gagcgccccc uuaucaauaa gaacauuccg     2220

aauuucaaau ggcuggcugg auucacaucu ggugauggcu acuucggcgu gaaucuaaaa     2280

aagguaaagg gcaacgcaaa gguauacgug ggacugagau ucucaaucuc acagcacauc     2340

agagacaaga accugaugaa uucauugaua acauaccuag gcugugguuc caucugggag     2400

aagaacaagu cugaguucag uuggcucgag uucgucguaa ccaaauucag cgauaucaac     2460

gacaagauca uuccgguauu ccaggaaaau acucugauug gcgucaaacu cgaggacuuu     2520

gaagauuggu gcaagguugc caaauugauc gaagagaaga aacaccugac cgaauccggu     2580

uuggaugaga uuaagaaaau caagcugaac augaacaaag gucgugucuu cuga           2634


<210>  28
<211>  711
<212>  RNA
<213>  Mus musculus

<400>  28
augucugagc caccucgggc ugagaccuuu guauuccugg accuagaagc cacugggcuc       60

ccaaacaugg acccugagau ugcagagaua ucccuuuuug cuguucaccg cucuucccug      120

gagaacccag aacgggauga uucugguucc uuggugcugc cccguguucu ggacaagcuc      180

acacugugca ugugcccgga gcgccccuuu acugccaagg ccagugagau uacugguuug      240

agcagcgaaa gccugaugca cugcgggaag gcugguuuca auggcgcugu gguaaggaca      300

cugcagggcu uccuaagccg ccaggagggc cccaucugcc uuguggccca caauggcuuc      360

gauuaugacu ucccacugcu gugcacggag cuacaacguc ugggugccca ucugccccaa      420

gacacugucu gccuggacac acugccugca uugcggggcc uggaccgugc ucacagccac      480

ggcaccaggg cucaaggccg caaaagcuac agccuggcca gucucuucca ccgcuacuuc      540

caggcugaac ccagugcugc ccauucagca gaaggugaug ugcacacccu gcuucugauc      600

uuccugcauc gugcuccuga gcugcucgcc ugggcagaug agcaggcccg cagcugggcu      660

cauauugagc ccauguacgu gccaccugau gguccaagcc ucgaagccug a               711


<210>  29
<211>  236
<212>  PRT
<213>  Mus musculus

<400>  29

Met Ser Glu Pro Pro Arg Ala Glu Thr Phe Val Phe Leu Asp Leu Glu 
1               5                   10                  15      


Ala Thr Gly Leu Pro Asn Met Asp Pro Glu Ile Ala Glu Ile Ser Leu 
            20                  25                  30          


Phe Ala Val His Arg Ser Ser Leu Glu Asn Pro Glu Arg Asp Asp Ser 
        35                  40                  45              


Gly Ser Leu Val Leu Pro Arg Val Leu Asp Lys Leu Thr Leu Cys Met 
    50                  55                  60                  


Cys Pro Glu Arg Pro Phe Thr Ala Lys Ala Ser Glu Ile Thr Gly Leu 
65                  70                  75                  80  


Ser Ser Glu Ser Leu Met His Cys Gly Lys Ala Gly Phe Asn Gly Ala 
                85                  90                  95      


Val Val Arg Thr Leu Gln Gly Phe Leu Ser Arg Gln Glu Gly Pro Ile 
            100                 105                 110         


Cys Leu Val Ala His Asn Gly Phe Asp Tyr Asp Phe Pro Leu Leu Cys 
        115                 120                 125             


Thr Glu Leu Gln Arg Leu Gly Ala His Leu Pro Gln Asp Thr Val Cys 
    130                 135                 140                 


Leu Asp Thr Leu Pro Ala Leu Arg Gly Leu Asp Arg Ala His Ser His 
145                 150                 155                 160 


Gly Thr Arg Ala Gln Gly Arg Lys Ser Tyr Ser Leu Ala Ser Leu Phe 
                165                 170                 175     


His Arg Tyr Phe Gln Ala Glu Pro Ser Ala Ala His Ser Ala Glu Gly 
            180                 185                 190         


Asp Val His Thr Leu Leu Leu Ile Phe Leu His Arg Ala Pro Glu Leu 
        195                 200                 205             


Leu Ala Trp Ala Asp Glu Gln Ala Arg Ser Trp Ala His Ile Glu Pro 
    210                 215                 220                 


Met Tyr Val Pro Pro Asp Gly Pro Ser Leu Glu Ala 
225                 230                 235     


<210>  30
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exemplary linker sequence

<400>  30

Gly Gly Gly 
1           


<210>  31
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exemplary linker sequence

<400>  31

Asp Gly Gly Gly Ser 
1               5   


<210>  32
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exemplary linker sequence

<400>  32

Thr Gly Glu Lys Pro 
1               5   


<210>  33
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exemplary linker sequence

<400>  33

Gly Gly Arg Arg 
1               


<210>  34
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exemplary linker sequence

<400>  34

Gly Gly Gly Gly Ser 
1               5   


<210>  35
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exemplary linker sequence

<400>  35

Glu Gly Lys Ser Ser Gly Ser Gly Ser Glu Ser Lys Val Asp 
1               5                   10                  


<210>  36
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exemplary linker sequence

<400>  36

Lys Glu Ser Gly Ser Val Ser Ser Glu Gln Leu Ala Gln Phe Arg Ser 
1               5                   10                  15      


Leu Asp 
        


<210>  37
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exemplary linker sequence

<400>  37

Gly Gly Arg Arg Gly Gly Gly Ser 
1               5               


<210>  38
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exemplary linker sequence

<400>  38

Leu Arg Gln Arg Asp Gly Glu Arg Pro 
1               5                   


<210>  39
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exemplary linker sequence

<400>  39

Leu Arg Gln Lys Asp Gly Gly Gly Ser Glu Arg Pro 
1               5                   10          


<210>  40
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exemplary linker sequence

<400>  40

Leu Arg Gln Lys Asp Gly Gly Gly Ser Gly Gly Gly Ser Glu Arg Pro 
1               5                   10                  15      


<210>  41
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Cleavage sequence by TEV protease


<220>
<221>  misc_feature
<222>  (2)..(3)
<223>  Xaa is any amino acid

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  Xaa is any amino acid

<220>
<221>  MISC_FEATURE
<222>  (7)..(7)
<223>  Xaa = Gly or Ser

<400>  41

Glu Xaa Xaa Tyr Xaa Gln Xaa 
1               5           


<210>  42
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Cleavage sequence by TEV protease

<400>  42

Glu Asn Leu Tyr Phe Gln Gly 
1               5           


<210>  43
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Cleavage sequence by TEV protease

<400>  43

Glu Asn Leu Tyr Phe Gln Ser 
1               5           


<210>  44
<211>  22
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Self-cleaving polypeptide comprising 2A site

<400>  44

Gly Ser Gly Ala Thr Asn Phe Ser Leu Leu Lys Gln Ala Gly Asp Val 
1               5                   10                  15      


Glu Glu Asn Pro Gly Pro 
            20          


<210>  45
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Self-cleaving polypeptide comprising 2A site

<400>  45

Ala Thr Asn Phe Ser Leu Leu Lys Gln Ala Gly Asp Val Glu Glu Asn 
1               5                   10                  15      


Pro Gly Pro 
            


<210>  46
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Self-cleaving polypeptide comprising 2A site

<400>  46

Leu Leu Lys Gln Ala Gly Asp Val Glu Glu Asn Pro Gly Pro 
1               5                   10                  


<210>  47
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Self-cleaving polypeptide comprising 2A site

<400>  47

Gly Ser Gly Glu Gly Arg Gly Ser Leu Leu Thr Cys Gly Asp Val Glu 
1               5                   10                  15      


Glu Asn Pro Gly Pro 
            20      


<210>  48
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Self-cleaving polypeptide comprising 2A site

<400>  48

Glu Gly Arg Gly Ser Leu Leu Thr Cys Gly Asp Val Glu Glu Asn Pro 
1               5                   10                  15      


Gly Pro 
        


<210>  49
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Self-cleaving polypeptide comprising 2A site

<400>  49

Leu Leu Thr Cys Gly Asp Val Glu Glu Asn Pro Gly Pro 
1               5                   10              


<210>  50
<211>  23
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Self-cleaving polypeptide comprising 2A site

<400>  50

Gly Ser Gly Gln Cys Thr Asn Tyr Ala Leu Leu Lys Leu Ala Gly Asp 
1               5                   10                  15      


Val Glu Ser Asn Pro Gly Pro 
            20              


<210>  51
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Self-cleaving polypeptide comprising 2A site

<400>  51

Gln Cys Thr Asn Tyr Ala Leu Leu Lys Leu Ala Gly Asp Val Glu Ser 
1               5                   10                  15      


Asn Pro Gly Pro 
            20  


<210>  52
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Self-cleaving polypeptide comprising 2A site

<400>  52

Leu Leu Lys Leu Ala Gly Asp Val Glu Ser Asn Pro Gly Pro 
1               5                   10                  


<210>  53
<211>  25
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Self-cleaving polypeptide comprising 2A site

<400>  53

Gly Ser Gly Val Lys Gln Thr Leu Asn Phe Asp Leu Leu Lys Leu Ala 
1               5                   10                  15      


Gly Asp Val Glu Ser Asn Pro Gly Pro 
            20                  25  


<210>  54
<211>  22
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Self-cleaving polypeptide comprising 2A site

<400>  54

Val Lys Gln Thr Leu Asn Phe Asp Leu Leu Lys Leu Ala Gly Asp Val 
1               5                   10                  15      


Glu Ser Asn Pro Gly Pro 
            20          


<210>  55
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Self-cleaving polypeptide comprising 2A site

<400>  55

Leu Leu Lys Leu Ala Gly Asp Val Glu Ser Asn Pro Gly Pro 
1               5                   10                  


<210>  56
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Self-cleaving polypeptide comprising 2A site

<400>  56

Leu Leu Asn Phe Asp Leu Leu Lys Leu Ala Gly Asp Val Glu Ser Asn 
1               5                   10                  15      


Pro Gly Pro 
            


<210>  57
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Self-cleaving polypeptide comprising 2A site

<400>  57

Thr Leu Asn Phe Asp Leu Leu Lys Leu Ala Gly Asp Val Glu Ser Asn 
1               5                   10                  15      


Pro Gly Pro 
            


<210>  58
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Self-cleaving polypeptide comprising 2A site

<400>  58

Leu Leu Lys Leu Ala Gly Asp Val Glu Ser Asn Pro Gly Pro 
1               5                   10                  


<210>  59
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Self-cleaving polypeptide comprising 2A site

<400>  59

Asn Phe Asp Leu Leu Lys Leu Ala Gly Asp Val Glu Ser Asn Pro Gly 
1               5                   10                  15      


Pro 
    


<210>  60
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Self-cleaving polypeptide comprising 2A site

<400>  60

Gln Leu Leu Asn Phe Asp Leu Leu Lys Leu Ala Gly Asp Val Glu Ser 
1               5                   10                  15      


Asn Pro Gly Pro 
            20  


<210>  61
<211>  24
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Self-cleaving polypeptide comprising 2A site

<400>  61

Ala Pro Val Lys Gln Thr Leu Asn Phe Asp Leu Leu Lys Leu Ala Gly 
1               5                   10                  15      


Asp Val Glu Ser Asn Pro Gly Pro 
            20                  


<210>  62
<211>  40
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Self-cleaving polypeptide comprising 2A site

<400>  62

Val Thr Glu Leu Leu Tyr Arg Met Lys Arg Ala Glu Thr Tyr Cys Pro 
1               5                   10                  15      


Arg Pro Leu Leu Ala Ile His Pro Thr Glu Ala Arg His Lys Gln Lys 
            20                  25                  30          


Ile Val Ala Pro Val Lys Gln Thr 
        35                  40  


<210>  63
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Self-cleaving polypeptide comprising 2A site

<400>  63

Leu Asn Phe Asp Leu Leu Lys Leu Ala Gly Asp Val Glu Ser Asn Pro 
1               5                   10                  15      


Gly Pro 
        


<210>  64
<211>  40
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Self-cleaving polypeptide comprising 2A site

<400>  64

Leu Leu Ala Ile His Pro Thr Glu Ala Arg His Lys Gln Lys Ile Val 
1               5                   10                  15      


Ala Pro Val Lys Gln Thr Leu Asn Phe Asp Leu Leu Lys Leu Ala Gly 
            20                  25                  30          


Asp Val Glu Ser Asn Pro Gly Pro 
        35                  40  


<210>  65
<211>  33
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Self-cleaving polypeptide comprising 2A site

<400>  65

Glu Ala Arg His Lys Gln Lys Ile Val Ala Pro Val Lys Gln Thr Leu 
1               5                   10                  15      


Asn Phe Asp Leu Leu Lys Leu Ala Gly Asp Val Glu Ser Asn Pro Gly 
            20                  25                  30          


Pro 
    


<210>  66
<211>  10
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Consensus Kozak sequence

<400>  66
gccrccatgg                                                              10


<210>  67
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct


<220>
<221>  misc_feature
<222>  (1)..(14)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (18)..(22)
<223>  n is a, c, g, or t

<400>  67
nnnnnnnnnn nnnnccgnnn nn                                                22


<210>  68
<211>  47
<212>  DNA
<213>  Homo sapiens

<400>  68
actctaaatc cagtgacaag tctgtctgcc tattcaccga ttttgat                     47


<210>  69
<211>  47
<212>  DNA
<213>  Homo sapiens

<400>  69
atcaaaatcg gtgaataggc agacagactt gtcactggat ttagagt                     47


