                         SEQUENCE LISTING

<110>  Shamina Rangwala
       Rangwala, Shamina
 
<120>  METHODS FOR SCREENING FOR MODULATORS OF GDF15-LIKE BIOLOGICAL 
       ACTIVITY

<130>  JBI5105USPSP

<140>  unknown
<141>  2016-10-11

<160>  30    

<170>  PatentIn version 3.5

<210>  1
<211>  339
<212>  PRT
<213>  artificial

<220>
<223>  GDF15-Fc fusion protein

<400>  1

Cys Pro Pro Cys Pro Ala Pro Glu Ala Ala Gly Gly Pro Ser Val Phe 
1               5                   10                  15      


Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro 
            20                  25                  30          


Glu Val Thr Cys Val Val Val Asp Val Ser Gln Glu Asp Pro Glu Val 
        35                  40                  45              


Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr 
    50                  55                  60                  


Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser Val 
65                  70                  75                  80  


Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys 
                85                  90                  95      


Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile Ser 
            100                 105                 110         


Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro 
        115                 120                 125             


Ser Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu Ser Cys Ala Val 
    130                 135                 140                 


Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly 
145                 150                 155                 160 


Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp 
                165                 170                 175     


Gly Ser Phe Phe Leu Val Ser Arg Leu Thr Val Asp Lys Ser Arg Trp 
            180                 185                 190         


Gln Glu Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His 
        195                 200                 205             


Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly Lys Gly Ser 
    210                 215                 220                 


Gly Gly Gly Ala Arg Asn Gly Asp His Cys Pro Leu Gly Pro Gly Arg 
225                 230                 235                 240 


Cys Cys Arg Leu His Thr Val Arg Ala Ser Leu Glu Asp Leu Gly Trp 
                245                 250                 255     


Ala Asp Trp Val Leu Ser Pro Arg Glu Val Gln Val Thr Met Cys Ile 
            260                 265                 270         


Gly Ala Cys Pro Ser Gln Phe Arg Ala Ala Asn Met His Ala Gln Ile 
        275                 280                 285             


Lys Thr Ser Leu His Arg Leu Lys Pro Asp Thr Val Pro Ala Pro Cys 
    290                 295                 300                 


Cys Val Pro Ala Ser Tyr Asn Pro Met Val Leu Ile Gln Lys Thr Asp 
305                 310                 315                 320 


Thr Gly Val Ser Leu Gln Thr Tyr Asp Asp Leu Leu Ala Lys Asp Cys 
                325                 330                 335     


His Cys Ile 
            


<210>  2
<211>  222
<212>  PRT
<213>  artificial

<220>
<223>  Fc

<400>  2

Cys Pro Pro Cys Pro Ala Pro Glu Ala Ala Gly Gly Pro Ser Val Phe 
1               5                   10                  15      


Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro 
            20                  25                  30          


Glu Val Thr Cys Val Val Val Asp Val Ser Gln Glu Asp Pro Glu Val 
        35                  40                  45              


Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr 
    50                  55                  60                  


Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser Val 
65                  70                  75                  80  


Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys 
                85                  90                  95      


Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile Ser 
            100                 105                 110         


Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro 
        115                 120                 125             


Ser Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu Trp Cys Leu Val 
    130                 135                 140                 


Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly 
145                 150                 155                 160 


Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp 
                165                 170                 175     


Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg Trp 
            180                 185                 190         


Gln Glu Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His 
        195                 200                 205             


Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly Lys 
    210                 215                 220         


<210>  3
<211>  394
<212>  PRT
<213>  human

<400>  3

Met Ile Val Phe Ile Phe Leu Ala Met Gly Leu Ser Leu Glu Asn Glu 
1               5                   10                  15      


Tyr Thr Ser Gln Thr Asn Asn Cys Thr Tyr Leu Arg Glu Gln Cys Leu 
            20                  25                  30          


Arg Asp Ala Asn Gly Cys Lys His Ala Trp Arg Val Met Glu Asp Ala 
        35                  40                  45              


Cys Asn Asp Ser Asp Pro Gly Asp Pro Cys Lys Met Arg Asn Ser Ser 
    50                  55                  60                  


Tyr Cys Asn Leu Ser Ile Gln Tyr Leu Val Glu Ser Asn Phe Gln Phe 
65                  70                  75                  80  


Lys Glu Cys Leu Cys Thr Asp Asp Phe Tyr Cys Thr Val Asn Lys Leu 
                85                  90                  95      


Leu Gly Lys Lys Cys Ile Asn Lys Ser Asp Asn Val Lys Glu Asp Lys 
            100                 105                 110         


Phe Lys Trp Asn Leu Thr Thr Arg Ser His His Gly Phe Lys Gly Met 
        115                 120                 125             


Trp Ser Cys Leu Glu Val Ala Glu Ala Cys Val Gly Asp Val Val Cys 
    130                 135                 140                 


Asn Ala Gln Leu Ala Ser Tyr Leu Lys Ala Cys Ser Ala Asn Gly Asn 
145                 150                 155                 160 


Pro Cys Asp Leu Lys Gln Cys Gln Ala Ala Ile Arg Phe Phe Tyr Gln 
                165                 170                 175     


Asn Ile Pro Phe Asn Ile Ala Gln Met Leu Ala Phe Cys Asp Cys Ala 
            180                 185                 190         


Gln Ser Asp Ile Pro Cys Gln Gln Ser Lys Glu Ala Leu His Ser Lys 
        195                 200                 205             


Thr Cys Ala Val Asn Met Val Pro Pro Pro Thr Cys Leu Ser Val Ile 
    210                 215                 220                 


Arg Ser Cys Gln Asn Asp Glu Leu Cys Arg Arg His Tyr Arg Thr Phe 
225                 230                 235                 240 


Gln Ser Lys Cys Trp Gln Arg Val Thr Arg Lys Cys His Glu Asp Glu 
                245                 250                 255     


Asn Cys Ile Ser Thr Leu Ser Lys Gln Asp Leu Thr Cys Ser Gly Ser 
            260                 265                 270         


Asp Asp Cys Lys Ala Ala Tyr Ile Asp Ile Leu Gly Thr Val Leu Gln 
        275                 280                 285             


Val Gln Cys Thr Cys Arg Thr Ile Thr Gln Ser Glu Glu Ser Leu Cys 
    290                 295                 300                 


Lys Ile Phe Gln His Met Leu His Arg Lys Ser Cys Phe Asn Tyr Pro 
305                 310                 315                 320 


Thr Leu Ser Asn Val Lys Gly Met Ala Leu Tyr Thr Arg Lys His Ala 
                325                 330                 335     


Asn Lys Ile Thr Leu Thr Gly Phe His Ser Pro Phe Asn Gly Glu Val 
            340                 345                 350         


Ile Tyr Ala Ala Met Cys Met Thr Val Thr Cys Gly Ile Leu Leu Leu 
        355                 360                 365             


Val Met Val Lys Leu Arg Thr Ser Arg Ile Ser Ser Lys Ala Arg Asp 
    370                 375                 380                 


Pro Ser Ser Ile Gln Ile Pro Gly Glu Leu 
385                 390                 


<210>  4
<211>  24
<212>  DNA
<213>  artificial

<220>
<223>  PCR primer

<400>  4
gtatggatga cctccactgt acag                                              24


<210>  5
<211>  30
<212>  DNA
<213>  artificial

<220>
<223>  PCR primer

<400>  5
caacaaatga acacatattg attgagtagg                                        30


<210>  6
<211>  23
<212>  DNA
<213>  artificial

<220>
<223>  PCR primer

<400>  6
gtgtggcgga ccgctatcag gac                                               23


<210>  7
<211>  20
<212>  DNA
<213>  mouse

<400>  7
gctgtgagca gtcatggaga                                                   20


<210>  8
<211>  20
<212>  DNA
<213>  mouse

<400>  8
ttccaccaaa gcctggatac                                                   20


<210>  9
<211>  18
<212>  DNA
<213>  mouse

<400>  9
ggcaccgagg caacagtt                                                     18


<210>  10
<211>  21
<212>  DNA
<213>  mouse

<400>  10
tcatccagca ggtgtttgac a                                                 21


<210>  11
<211>  19
<212>  PRT
<213>  artificial

<220>
<223>  signal peptide

<400>  11

Met Ala Trp Val Trp Thr Leu Leu Phe Leu Met Ala Ala Ala Gln Ser 
1               5                   10                  15      


Ile Gln Ala 
            


<210>  12
<211>  8
<212>  PRT
<213>  artificial

<220>
<223>  flag tag

<400>  12

Asp Tyr Lys Asp Asp Asp Asp Lys 
1               5               


<210>  13
<211>  376
<212>  PRT
<213>  human

<400>  13

Ser Gln Thr Asn Asn Cys Thr Tyr Leu Arg Glu Gln Cys Leu Arg Asp 
1               5                   10                  15      


Ala Asn Gly Cys Lys His Ala Trp Arg Val Met Glu Asp Ala Cys Asn 
            20                  25                  30          


Asp Ser Asp Pro Gly Asp Pro Cys Lys Met Arg Asn Ser Ser Tyr Cys 
        35                  40                  45              


Asn Leu Ser Ile Gln Tyr Leu Val Glu Ser Asn Phe Gln Phe Lys Glu 
    50                  55                  60                  


Cys Leu Cys Thr Asp Asp Phe Tyr Cys Thr Val Asn Lys Leu Leu Gly 
65                  70                  75                  80  


Lys Lys Cys Ile Asn Lys Ser Asp Asn Val Lys Glu Asp Lys Phe Lys 
                85                  90                  95      


Trp Asn Leu Thr Thr Arg Ser His His Gly Phe Lys Gly Met Trp Ser 
            100                 105                 110         


Cys Leu Glu Val Ala Glu Ala Cys Val Gly Asp Val Val Cys Asn Ala 
        115                 120                 125             


Gln Leu Ala Ser Tyr Leu Lys Ala Cys Ser Ala Asn Gly Asn Pro Cys 
    130                 135                 140                 


Asp Leu Lys Gln Cys Gln Ala Ala Ile Arg Phe Phe Tyr Gln Asn Ile 
145                 150                 155                 160 


Pro Phe Asn Ile Ala Gln Met Leu Ala Phe Cys Asp Cys Ala Gln Ser 
                165                 170                 175     


Asp Ile Pro Cys Gln Gln Ser Lys Glu Ala Leu His Ser Lys Thr Cys 
            180                 185                 190         


Ala Val Asn Met Val Pro Pro Pro Thr Cys Leu Ser Val Ile Arg Ser 
        195                 200                 205             


Cys Gln Asn Asp Glu Leu Cys Arg Arg His Tyr Arg Thr Phe Gln Ser 
    210                 215                 220                 


Lys Cys Trp Gln Arg Val Thr Arg Lys Cys His Glu Asp Glu Asn Cys 
225                 230                 235                 240 


Ile Ser Thr Leu Ser Lys Gln Asp Leu Thr Cys Ser Gly Ser Asp Asp 
                245                 250                 255     


Cys Lys Ala Ala Tyr Ile Asp Ile Leu Gly Thr Val Leu Gln Val Gln 
            260                 265                 270         


Cys Thr Cys Arg Thr Ile Thr Gln Ser Glu Glu Ser Leu Cys Lys Ile 
        275                 280                 285             


Phe Gln His Met Leu His Arg Lys Ser Cys Phe Asn Tyr Pro Thr Leu 
    290                 295                 300                 


Ser Asn Val Lys Gly Met Ala Leu Tyr Thr Arg Lys His Ala Asn Lys 
305                 310                 315                 320 


Ile Thr Leu Thr Gly Phe His Ser Pro Phe Asn Gly Glu Val Ile Tyr 
                325                 330                 335     


Ala Ala Met Cys Met Thr Val Thr Cys Gly Ile Leu Leu Leu Val Met 
            340                 345                 350         


Val Lys Leu Arg Thr Ser Arg Ile Ser Ser Lys Ala Arg Asp Pro Ser 
        355                 360                 365             


Ser Ile Gln Ile Pro Gly Glu Leu 
    370                 375     


<210>  14
<211>  441
<212>  PRT
<213>  human

<400>  14

Asp Arg Leu Asp Cys Val Lys Ala Ser Asp Gln Cys Leu Lys Glu Gln 
1               5                   10                  15      


Ser Cys Ser Thr Lys Tyr Arg Thr Leu Arg Gln Cys Val Ala Gly Lys 
            20                  25                  30          


Glu Thr Asn Phe Ser Leu Ala Ser Gly Leu Glu Ala Lys Asp Glu Cys 
        35                  40                  45              


Arg Ser Ala Met Glu Ala Leu Lys Gln Lys Ser Leu Tyr Asn Cys Arg 
    50                  55                  60                  


Cys Lys Arg Gly Met Lys Lys Glu Lys Asn Cys Leu Arg Ile Tyr Trp 
65                  70                  75                  80  


Ser Met Tyr Gln Ser Leu Gln Gly Asn Asp Leu Leu Glu Asp Ser Pro 
                85                  90                  95      


Tyr Glu Pro Val Asn Ser Arg Leu Ser Asp Ile Phe Arg Val Val Pro 
            100                 105                 110         


Phe Ile Ser Asp Val Phe Gln Gln Val Glu His Ile Pro Lys Gly Asn 
        115                 120                 125             


Asn Cys Leu Asp Ala Ala Lys Ala Cys Asn Leu Asp Asp Ile Cys Lys 
    130                 135                 140                 


Lys Tyr Arg Ser Ala Tyr Ile Thr Pro Cys Thr Thr Ser Val Ser Asn 
145                 150                 155                 160 


Asp Val Cys Asn Arg Arg Lys Cys His Lys Ala Leu Arg Gln Phe Phe 
                165                 170                 175     


Asp Lys Val Pro Ala Lys His Ser Tyr Gly Met Leu Phe Cys Ser Cys 
            180                 185                 190         


Arg Asp Ile Ala Cys Thr Glu Arg Arg Arg Gln Thr Ile Val Pro Val 
        195                 200                 205             


Cys Ser Tyr Glu Glu Arg Glu Lys Pro Asn Cys Leu Asn Leu Gln Asp 
    210                 215                 220                 


Ser Cys Lys Thr Asn Tyr Ile Cys Arg Ser Arg Leu Ala Asp Phe Phe 
225                 230                 235                 240 


Thr Asn Cys Gln Pro Glu Ser Arg Ser Val Ser Ser Cys Leu Lys Glu 
                245                 250                 255     


Asn Tyr Ala Asp Cys Leu Leu Ala Tyr Ser Gly Leu Ile Gly Thr Val 
            260                 265                 270         


Met Thr Pro Asn Tyr Ile Asp Ser Ser Ser Leu Ser Val Ala Pro Trp 
        275                 280                 285             


Cys Asp Cys Ser Asn Ser Gly Asn Asp Leu Glu Glu Cys Leu Lys Phe 
    290                 295                 300                 


Leu Asn Phe Phe Lys Asp Asn Thr Cys Leu Lys Asn Ala Ile Gln Ala 
305                 310                 315                 320 


Phe Gly Asn Gly Ser Asp Val Thr Val Trp Gln Pro Ala Phe Pro Val 
                325                 330                 335     


Gln Thr Thr Thr Ala Thr Thr Thr Thr Ala Leu Arg Val Lys Asn Lys 
            340                 345                 350         


Pro Leu Gly Pro Ala Gly Ser Glu Asn Glu Ile Pro Thr His Val Leu 
        355                 360                 365             


Pro Pro Cys Ala Asn Leu Gln Ala Gln Lys Leu Lys Ser Asn Val Ser 
    370                 375                 380                 


Gly Asn Thr His Leu Cys Ile Ser Asn Gly Asn Tyr Glu Lys Glu Gly 
385                 390                 395                 400 


Leu Gly Ala Ser Ser His Ile Thr Thr Lys Ser Met Ala Ala Pro Pro 
                405                 410                 415     


Ser Cys Gly Leu Ser Pro Leu Leu Val Leu Val Val Thr Ala Leu Ser 
            420                 425                 430         


Thr Leu Leu Ser Leu Thr Glu Thr Ser 
        435                 440     


<210>  15
<211>  443
<212>  PRT
<213>  human

<400>  15

Ser Pro Ser Ser Leu Gln Gly Pro Glu Leu His Gly Trp Arg Pro Pro 
1               5                   10                  15      


Val Asp Cys Val Arg Ala Asn Glu Leu Cys Ala Ala Glu Ser Asn Cys 
            20                  25                  30          


Ser Ser Arg Tyr Arg Thr Leu Arg Gln Cys Leu Ala Gly Arg Asp Arg 
        35                  40                  45              


Asn Thr Met Leu Ala Asn Lys Glu Cys Gln Ala Ala Leu Glu Val Leu 
    50                  55                  60                  


Gln Glu Ser Pro Leu Tyr Asp Cys Arg Cys Lys Arg Gly Met Lys Lys 
65                  70                  75                  80  


Glu Leu Gln Cys Leu Gln Ile Tyr Trp Ser Ile His Leu Gly Leu Thr 
                85                  90                  95      


Glu Gly Glu Glu Phe Tyr Glu Ala Ser Pro Tyr Glu Pro Val Thr Ser 
            100                 105                 110         


Arg Leu Ser Asp Ile Phe Arg Leu Ala Ser Ile Phe Ser Gly Thr Gly 
        115                 120                 125             


Ala Asp Pro Val Val Ser Ala Lys Ser Asn His Cys Leu Asp Ala Ala 
    130                 135                 140                 


Lys Ala Cys Asn Leu Asn Asp Asn Cys Lys Lys Leu Arg Ser Ser Tyr 
145                 150                 155                 160 


Ile Ser Ile Cys Asn Arg Glu Ile Ser Pro Thr Glu Arg Cys Asn Arg 
                165                 170                 175     


Arg Lys Cys His Lys Ala Leu Arg Gln Phe Phe Asp Arg Val Pro Ser 
            180                 185                 190         


Glu Tyr Thr Tyr Arg Met Leu Phe Cys Ser Cys Gln Asp Gln Ala Cys 
        195                 200                 205             


Ala Glu Arg Arg Arg Gln Thr Ile Leu Pro Ser Cys Ser Tyr Glu Asp 
    210                 215                 220                 


Lys Glu Lys Pro Asn Cys Leu Asp Leu Arg Gly Val Cys Arg Thr Asp 
225                 230                 235                 240 


His Leu Cys Arg Ser Arg Leu Ala Asp Phe His Ala Asn Cys Arg Ala 
                245                 250                 255     


Ser Tyr Gln Thr Val Thr Ser Cys Pro Ala Asp Asn Tyr Gln Ala Cys 
            260                 265                 270         


Leu Gly Ser Tyr Ala Gly Met Ile Gly Phe Asp Met Thr Pro Asn Tyr 
        275                 280                 285             


Val Asp Ser Ser Pro Thr Gly Ile Val Val Ser Pro Trp Cys Ser Cys 
    290                 295                 300                 


Arg Gly Ser Gly Asn Met Glu Glu Glu Cys Glu Lys Phe Leu Arg Asp 
305                 310                 315                 320 


Phe Thr Glu Asn Pro Cys Leu Arg Asn Ala Ile Gln Ala Phe Gly Asn 
                325                 330                 335     


Gly Thr Asp Val Asn Val Ser Pro Lys Gly Pro Ser Phe Gln Ala Thr 
            340                 345                 350         


Gln Ala Pro Arg Val Glu Lys Thr Pro Ser Leu Pro Asp Asp Leu Ser 
        355                 360                 365             


Asp Ser Thr Ser Leu Gly Thr Ser Val Ile Thr Thr Cys Thr Ser Val 
    370                 375                 380                 


Gln Glu Gln Gly Leu Lys Ala Asn Asn Ser Lys Glu Leu Ser Met Cys 
385                 390                 395                 400 


Phe Thr Glu Leu Thr Thr Asn Ile Ile Pro Gly Ser Asn Lys Val Ile 
                405                 410                 415     


Lys Pro Asn Ser Gly Pro Ser Arg Ala Arg Pro Ser Ala Ala Leu Thr 
            420                 425                 430         


Val Leu Ser Val Leu Met Leu Lys Leu Ala Leu 
        435                 440             


<210>  16
<211>  370
<212>  PRT
<213>  human

<400>  16

Gly Asp Pro Leu Pro Thr Glu Ser Arg Leu Met Asn Ser Cys Leu Gln 
1               5                   10                  15      


Ala Arg Arg Lys Cys Gln Ala Asp Pro Thr Cys Ser Ala Ala Tyr His 
            20                  25                  30          


His Leu Asp Ser Cys Thr Ser Ser Ile Ser Thr Pro Leu Pro Ser Glu 
        35                  40                  45              


Glu Pro Ser Val Pro Ala Asp Cys Leu Glu Ala Ala Gln Gln Leu Arg 
    50                  55                  60                  


Asn Ser Ser Leu Ile Gly Cys Met Cys His Arg Arg Met Lys Asn Gln 
65                  70                  75                  80  


Val Ala Cys Leu Asp Ile Tyr Trp Thr Val His Arg Ala Arg Ser Leu 
                85                  90                  95      


Gly Asn Tyr Glu Leu Asp Val Ser Pro Tyr Glu Asp Thr Val Thr Ser 
            100                 105                 110         


Lys Pro Trp Lys Met Asn Leu Ser Lys Leu Asn Met Leu Lys Pro Asp 
        115                 120                 125             


Ser Asp Leu Cys Leu Lys Phe Ala Met Leu Cys Thr Leu Asn Asp Lys 
    130                 135                 140                 


Cys Asp Arg Leu Arg Lys Ala Tyr Gly Glu Ala Cys Ser Gly Pro His 
145                 150                 155                 160 


Cys Gln Arg His Val Cys Leu Arg Gln Leu Leu Thr Phe Phe Glu Lys 
                165                 170                 175     


Ala Ala Glu Pro His Ala Gln Gly Leu Leu Leu Cys Pro Cys Ala Pro 
            180                 185                 190         


Asn Asp Arg Gly Cys Gly Glu Arg Arg Arg Asn Thr Ile Ala Pro Asn 
        195                 200                 205             


Cys Ala Leu Pro Pro Val Ala Pro Asn Cys Leu Glu Leu Arg Arg Leu 
    210                 215                 220                 


Cys Phe Ser Asp Pro Leu Cys Arg Ser Arg Leu Val Asp Phe Gln Thr 
225                 230                 235                 240 


His Cys His Pro Met Asp Ile Leu Gly Thr Cys Ala Thr Glu Gln Ser 
                245                 250                 255     


Arg Cys Leu Arg Ala Tyr Leu Gly Leu Ile Gly Thr Ala Met Thr Pro 
            260                 265                 270         


Asn Phe Val Ser Asn Val Asn Thr Ser Val Ala Leu Ser Cys Thr Cys 
        275                 280                 285             


Arg Gly Ser Gly Asn Leu Gln Glu Glu Cys Glu Met Leu Glu Gly Phe 
    290                 295                 300                 


Phe Ser His Asn Pro Cys Leu Thr Glu Ala Ile Ala Ala Lys Met Arg 
305                 310                 315                 320 


Phe His Ser Gln Leu Phe Ser Gln Asp Trp Pro His Pro Thr Phe Ala 
                325                 330                 335     


Val Met Ala His Gln Asn Glu Asn Pro Ala Val Arg Pro Gln Pro Trp 
            340                 345                 350         


Val Pro Ser Leu Phe Ser Cys Thr Leu Pro Leu Ile Leu Leu Leu Ser 
        355                 360                 365             


Leu Trp 
    370 


<210>  17
<211>  279
<212>  PRT
<213>  human

<400>  17

Val Gly Gly Asn Arg Cys Val Asp Ala Ala Glu Ala Cys Thr Ala Asp 
1               5                   10                  15      


Ala Arg Cys Gln Arg Leu Arg Ser Glu Tyr Val Ala Gln Cys Leu Gly 
            20                  25                  30          


Arg Ala Ala Gln Gly Gly Cys Pro Arg Ala Arg Cys Arg Arg Ala Leu 
        35                  40                  45              


Arg Arg Phe Phe Ala Arg Gly Pro Pro Ala Leu Thr His Ala Leu Leu 
    50                  55                  60                  


Phe Cys Pro Cys Ala Gly Pro Ala Cys Ala Glu Arg Arg Arg Gln Thr 
65                  70                  75                  80  


Phe Val Pro Ser Cys Ala Phe Ser Gly Pro Gly Pro Ala Pro Pro Ser 
                85                  90                  95      


Cys Leu Glu Pro Leu Asn Phe Cys Glu Arg Ser Arg Val Cys Arg Cys 
            100                 105                 110         


Ala Arg Ala Ala Ala Gly Pro Trp Arg Gly Trp Gly Arg Gly Leu Ser 
        115                 120                 125             


Pro Ala His Arg Pro Pro Ala Ala Gln Ala Ser Pro Pro Gly Leu Ser 
    130                 135                 140                 


Gly Leu Val His Pro Ser Ala Gln Arg Pro Arg Arg Leu Pro Ala Gly 
145                 150                 155                 160 


Pro Gly Arg Pro Leu Pro Ala Arg Leu Arg Gly Pro Arg Gly Val Pro 
                165                 170                 175     


Ala Gly Thr Ala Val Thr Pro Asn Tyr Val Asp Asn Val Ser Ala Arg 
            180                 185                 190         


Val Ala Pro Trp Cys Asp Cys Gly Ala Ser Gly Asn Arg Arg Glu Asp 
        195                 200                 205             


Cys Glu Ala Phe Arg Gly Leu Phe Thr Arg Asn Arg Cys Leu Asp Gly 
    210                 215                 220                 


Ala Ile Gln Ala Phe Ala Ser Gly Trp Pro Pro Val Leu Leu Asp Gln 
225                 230                 235                 240 


Leu Asn Pro Gln Gly Asp Pro Glu His Ser Leu Leu Gln Val Ser Ser 
                245                 250                 255     


Thr Gly Arg Ala Leu Glu Arg Arg Ser Leu Leu Ser Ile Leu Pro Val 
            260                 265                 270         


Leu Ala Leu Pro Ala Leu Leu 
        275                 


<210>  18
<211>  9
<212>  DNA
<213>  artificial

<220>
<223>  Kozak sequence

<400>  18
gccgccacc                                                                9


<210>  19
<211>  333
<212>  PRT
<213>  human

<400>  19

Ser Gln Thr Asn Asn Cys Thr Tyr Leu Arg Glu Gln Cys Leu Arg Asp 
1               5                   10                  15      


Ala Asn Gly Cys Lys His Ala Trp Arg Val Met Glu Asp Ala Cys Asn 
            20                  25                  30          


Asp Ser Asp Pro Gly Asp Pro Cys Lys Met Arg Asn Ser Ser Tyr Cys 
        35                  40                  45              


Asn Leu Ser Ile Gln Tyr Leu Val Glu Ser Asn Phe Gln Phe Lys Glu 
    50                  55                  60                  


Cys Leu Cys Thr Asp Asp Phe Tyr Cys Thr Val Asn Lys Leu Leu Gly 
65                  70                  75                  80  


Lys Lys Cys Ile Asn Lys Ser Asp Asn Val Lys Glu Asp Lys Phe Lys 
                85                  90                  95      


Trp Asn Leu Thr Thr Arg Ser His His Gly Phe Lys Gly Met Trp Ser 
            100                 105                 110         


Cys Leu Glu Val Ala Glu Ala Cys Val Gly Asp Val Val Cys Asn Ala 
        115                 120                 125             


Gln Leu Ala Ser Tyr Leu Lys Ala Cys Ser Ala Asn Gly Asn Pro Cys 
    130                 135                 140                 


Asp Leu Lys Gln Cys Gln Ala Ala Ile Arg Phe Phe Tyr Gln Asn Ile 
145                 150                 155                 160 


Pro Phe Asn Ile Ala Gln Met Leu Ala Phe Cys Asp Cys Ala Gln Ser 
                165                 170                 175     


Asp Ile Pro Cys Gln Gln Ser Lys Glu Ala Leu His Ser Lys Thr Cys 
            180                 185                 190         


Ala Val Asn Met Val Pro Pro Pro Thr Cys Leu Ser Val Ile Arg Ser 
        195                 200                 205             


Cys Gln Asn Asp Glu Leu Cys Arg Arg His Tyr Arg Thr Phe Gln Ser 
    210                 215                 220                 


Lys Cys Trp Gln Arg Val Thr Arg Lys Cys His Glu Asp Glu Asn Cys 
225                 230                 235                 240 


Ile Ser Thr Leu Ser Lys Gln Asp Leu Thr Cys Ser Gly Ser Asp Asp 
                245                 250                 255     


Cys Lys Ala Ala Tyr Ile Asp Ile Leu Gly Thr Val Leu Gln Val Gln 
            260                 265                 270         


Cys Thr Cys Arg Thr Ile Thr Gln Ser Glu Glu Ser Leu Cys Lys Ile 
        275                 280                 285             


Phe Gln His Met Leu His Arg Lys Ser Cys Phe Asn Tyr Pro Thr Leu 
    290                 295                 300                 


Ser Asn Val Lys Gly Met Ala Leu Tyr Thr Arg Lys His Ala Asn Lys 
305                 310                 315                 320 


Ile Thr Leu Thr Gly Phe His Ser Pro Phe Asn Gly Glu 
                325                 330             


<210>  20
<211>  15
<212>  PRT
<213>  artificial

<220>
<223>  Avi tag

<400>  20

Gly Leu Asn Asp Ile Phe Glu Ala Gln Lys Ile Glu Trp His Glu 
1               5                   10                  15  


<210>  21
<211>  308
<212>  PRT
<213>  human

<400>  21

Met Pro Gly Gln Glu Leu Arg Thr Val Asn Gly Ser Gln Met Leu Leu 
1               5                   10                  15      


Val Leu Leu Val Leu Ser Trp Leu Pro His Gly Gly Ala Leu Ser Leu 
            20                  25                  30          


Ala Glu Ala Ser Arg Ala Ser Phe Pro Gly Pro Ser Glu Leu His Ser 
        35                  40                  45              


Glu Asp Ser Arg Phe Arg Glu Leu Arg Lys Arg Tyr Glu Asp Leu Leu 
    50                  55                  60                  


Thr Arg Leu Arg Ala Asn Gln Ser Trp Glu Asp Ser Asn Thr Asp Leu 
65                  70                  75                  80  


Val Pro Ala Pro Ala Val Arg Ile Leu Thr Pro Glu Val Arg Leu Gly 
                85                  90                  95      


Ser Gly Gly His Leu His Leu Arg Ile Ser Arg Ala Ala Leu Pro Glu 
            100                 105                 110         


Gly Leu Pro Glu Ala Ser Arg Leu His Arg Ala Leu Phe Arg Leu Ser 
        115                 120                 125             


Pro Thr Ala Ser Arg Ser Trp Asp Val Thr Arg Pro Leu Arg Arg Gln 
    130                 135                 140                 


Leu Ser Leu Ala Arg Pro Gln Ala Pro Ala Leu His Leu Arg Leu Ser 
145                 150                 155                 160 


Pro Pro Pro Ser Gln Ser Asp Gln Leu Leu Ala Glu Ser Ser Ser Ala 
                165                 170                 175     


Arg Pro Gln Leu Glu Leu His Leu Arg Pro Gln Ala Ala Arg Gly Arg 
            180                 185                 190         


Arg Arg Ala Arg Ala Arg Asn Gly Asp His Cys Pro Leu Gly Pro Gly 
        195                 200                 205             


Arg Cys Cys Arg Leu His Thr Val Arg Ala Ser Leu Glu Asp Leu Gly 
    210                 215                 220                 


Trp Ala Asp Trp Val Leu Ser Pro Arg Glu Val Gln Val Thr Met Cys 
225                 230                 235                 240 


Ile Gly Ala Cys Pro Ser Gln Phe Arg Ala Ala Asn Met His Ala Gln 
                245                 250                 255     


Ile Lys Thr Ser Leu His Arg Leu Lys Pro Asp Thr Val Pro Ala Pro 
            260                 265                 270         


Cys Cys Val Pro Ala Ser Tyr Asn Pro Met Val Leu Ile Gln Lys Thr 
        275                 280                 285             


Asp Thr Gly Val Ser Leu Gln Thr Tyr Asp Asp Leu Leu Ala Lys Asp 
    290                 295                 300                 


Cys His Cys Ile 
305             


<210>  22
<211>  10
<212>  PRT
<213>  artificial

<220>
<223>  FLAG tag

<400>  22

Glu Phe Asp Tyr Lys Asp Asp Asp Asp Lys 
1               5                   10  


<210>  23
<211>  585
<212>  PRT
<213>  human

<400>  23

Asp Ala His Lys Ser Glu Val Ala His Arg Phe Lys Asp Leu Gly Glu 
1               5                   10                  15      


Glu Asn Phe Lys Ala Leu Val Leu Ile Ala Phe Ala Gln Tyr Leu Gln 
            20                  25                  30          


Gln Ser Pro Phe Glu Asp His Val Lys Leu Val Asn Glu Val Thr Glu 
        35                  40                  45              


Phe Ala Lys Thr Cys Val Ala Asp Glu Ser Ala Glu Asn Cys Asp Lys 
    50                  55                  60                  


Ser Leu His Thr Leu Phe Gly Asp Lys Leu Cys Thr Val Ala Thr Leu 
65                  70                  75                  80  


Arg Glu Thr Tyr Gly Glu Met Ala Asp Cys Cys Ala Lys Gln Glu Pro 
                85                  90                  95      


Glu Arg Asn Glu Cys Phe Leu Gln His Lys Asp Asp Asn Pro Asn Leu 
            100                 105                 110         


Pro Arg Leu Val Arg Pro Glu Val Asp Val Met Cys Thr Ala Phe His 
        115                 120                 125             


Asp Asn Glu Glu Thr Phe Leu Lys Lys Tyr Leu Tyr Glu Ile Ala Arg 
    130                 135                 140                 


Arg His Pro Tyr Phe Tyr Ala Pro Glu Leu Leu Phe Phe Ala Lys Arg 
145                 150                 155                 160 


Tyr Lys Ala Ala Phe Thr Glu Cys Cys Gln Ala Ala Asp Lys Ala Ala 
                165                 170                 175     


Cys Leu Leu Pro Lys Leu Asp Glu Leu Arg Asp Glu Gly Lys Ala Ser 
            180                 185                 190         


Ser Ala Lys Gln Arg Leu Lys Cys Ala Ser Leu Gln Lys Phe Gly Glu 
        195                 200                 205             


Arg Ala Phe Lys Ala Trp Ala Val Ala Arg Leu Ser Gln Arg Phe Pro 
    210                 215                 220                 


Lys Ala Glu Phe Ala Glu Val Ser Lys Leu Val Thr Asp Leu Thr Lys 
225                 230                 235                 240 


Val His Thr Glu Cys Cys His Gly Asp Leu Leu Glu Cys Ala Asp Asp 
                245                 250                 255     


Arg Ala Asp Leu Ala Lys Tyr Ile Cys Glu Asn Gln Asp Ser Ile Ser 
            260                 265                 270         


Ser Lys Leu Lys Glu Cys Cys Glu Lys Pro Leu Leu Glu Lys Ser His 
        275                 280                 285             


Cys Ile Ala Glu Val Glu Asn Asp Glu Met Pro Ala Asp Leu Pro Ser 
    290                 295                 300                 


Leu Ala Ala Asp Phe Val Glu Ser Lys Asp Val Cys Lys Asn Tyr Ala 
305                 310                 315                 320 


Glu Ala Lys Asp Val Phe Leu Gly Met Phe Leu Tyr Glu Tyr Ala Arg 
                325                 330                 335     


Arg His Pro Asp Tyr Ser Val Val Leu Leu Leu Arg Leu Ala Lys Thr 
            340                 345                 350         


Tyr Glu Thr Thr Leu Glu Lys Cys Cys Ala Ala Ala Asp Pro His Glu 
        355                 360                 365             


Cys Tyr Ala Lys Val Phe Asp Glu Phe Lys Pro Leu Val Glu Glu Pro 
    370                 375                 380                 


Gln Asn Leu Ile Lys Gln Asn Cys Glu Leu Phe Glu Gln Leu Gly Glu 
385                 390                 395                 400 


Tyr Lys Phe Gln Asn Ala Leu Leu Val Arg Tyr Thr Lys Lys Val Pro 
                405                 410                 415     


Gln Val Ser Thr Pro Thr Leu Val Glu Val Ser Arg Asn Leu Gly Lys 
            420                 425                 430         


Val Gly Ser Lys Cys Cys Lys His Pro Glu Ala Lys Arg Met Pro Cys 
        435                 440                 445             


Ala Glu Asp Tyr Leu Ser Val Val Leu Asn Gln Leu Cys Val Leu His 
    450                 455                 460                 


Glu Lys Thr Pro Val Ser Asp Arg Val Thr Lys Cys Cys Thr Glu Ser 
465                 470                 475                 480 


Leu Val Asn Arg Arg Pro Cys Phe Ser Ala Leu Glu Val Asp Glu Thr 
                485                 490                 495     


Tyr Val Pro Lys Glu Phe Asn Ala Glu Thr Phe Thr Phe His Ala Asp 
            500                 505                 510         


Ile Cys Thr Leu Ser Glu Lys Glu Arg Gln Ile Lys Lys Gln Thr Ala 
        515                 520                 525             


Leu Val Glu Leu Val Lys His Lys Pro Lys Ala Thr Lys Glu Gln Leu 
    530                 535                 540                 


Lys Ala Val Met Asp Asp Phe Ala Ala Phe Val Glu Lys Cys Cys Lys 
545                 550                 555                 560 


Ala Asp Asp Lys Glu Thr Cys Phe Ala Glu Glu Gly Lys Lys Leu Val 
                565                 570                 575     


Ala Ala Ser Gln Ala Ala Leu Gly Leu 
            580                 585 


<210>  24
<211>  22
<212>  PRT
<213>  artificial

<220>
<223>  genetic linker

<400>  24

Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
1               5                   10                  15      


Ser Gly Gly Gly Gly Ser 
            20          


<210>  25
<211>  5
<212>  PRT
<213>  artificial

<220>
<223>  genetic linker

<400>  25

Gly Ser Gly Gly Gly 
1               5   


<210>  26
<211>  42
<212>  PRT
<213>  artificial

<220>
<223>  Linker

<400>  26

Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
1               5                   10                  15      


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
            20                  25                  30          


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
        35                  40          


<210>  27
<211>  333
<212>  PRT
<213>  cynomolgus monkey

<400>  27

Ser Gln Thr Asn Asn Cys Thr Tyr Leu Arg Glu Gln Cys Leu His Asp 
1               5                   10                  15      


Ala Asn Gly Cys Lys His Ala Trp Arg Ile Met Glu Asp Ala Cys Asn 
            20                  25                  30          


Asp Ser Asp Pro Gly Asp Pro Cys Lys Met Asn Asn Ser Ser Tyr Cys 
        35                  40                  45              


Asn Leu Ser Ile Gln Tyr Leu Val Glu Ser Asn Phe Arg Phe Lys Glu 
    50                  55                  60                  


Cys Leu Cys Thr Asp Asp Phe Tyr Cys Thr Val Asn Lys Leu Leu Gly 
65                  70                  75                  80  


Lys Glu Cys Val Asn Lys Ser Asp Asn Met Arg Glu Asp Lys Phe Lys 
                85                  90                  95      


Trp Asn Leu Thr Thr His Ser His His Gly Phe Lys Gly Met Trp Ser 
            100                 105                 110         


Cys Leu Glu Val Ala Glu Ala Cys Val Gly Asp Val Val Cys Asn Ala 
        115                 120                 125             


Gln Leu Ala Ser Tyr Leu Lys Ala Cys Ser Ala Asn Gly Asn Pro Cys 
    130                 135                 140                 


Asp Val Lys His Cys Gln Ala Ala Ile Arg Phe Phe Tyr Gln Asn Ile 
145                 150                 155                 160 


Pro Phe Asn Ile Ala Gln Met Leu Ala Phe Cys Asp Cys Ser Gln Ser 
                165                 170                 175     


Asp Ile Pro Cys Gln Gln Ser Lys Glu Ala Leu His Ser Lys Pro Cys 
            180                 185                 190         


Ala Leu Asn Met Val Pro Pro Pro Thr Cys Leu Asn Val Ile Arg Ser 
        195                 200                 205             


Cys Gln Asn Asp Glu Leu Cys Arg Arg His Tyr Arg Thr Phe Gln Ser 
    210                 215                 220                 


Lys Cys Trp Gln Arg Val Thr Arg Lys Cys His Glu Asp Glu Asn Cys 
225                 230                 235                 240 


Ile Ser Ala Leu Ser Lys Gln Asp Leu Thr Cys Ser Gly Ser Asp Asp 
                245                 250                 255     


Cys Lys Ala Ala Tyr Ile Asp Ile Leu Gly Thr Val Leu Gln Val Gln 
            260                 265                 270         


Cys Asn Cys Arg Thr Ile Thr Gln Ser Glu Glu Ser Leu Cys Lys Ile 
        275                 280                 285             


Phe Gln His Met Leu His Arg Lys Ser Cys Phe Asn Tyr Pro Thr Leu 
    290                 295                 300                 


Ser Asn Val Lys Ser Met Ala Leu Tyr Thr Arg Lys His Thr Asn Lys 
305                 310                 315                 320 


Ile Thr Leu Thr Gly Phe Gln Ser Pro Phe Asn Gly Glu 
                325                 330             


<210>  28
<211>  585
<212>  PRT
<213>  artificial

<220>
<223>  fusion protein

<400>  28

Ser Gln Thr Asn Asn Cys Thr Tyr Leu Arg Glu Gln Cys Leu Arg Asp 
1               5                   10                  15      


Ala Asn Gly Cys Lys His Ala Trp Arg Val Met Glu Asp Ala Cys Asn 
            20                  25                  30          


Asp Ser Asp Pro Gly Asp Pro Cys Lys Met Arg Asn Ser Ser Tyr Cys 
        35                  40                  45              


Asn Leu Ser Ile Gln Tyr Leu Val Glu Ser Asn Phe Gln Phe Lys Glu 
    50                  55                  60                  


Cys Leu Cys Thr Asp Asp Phe Tyr Cys Thr Val Asn Lys Leu Leu Gly 
65                  70                  75                  80  


Lys Lys Cys Ile Asn Lys Ser Asp Asn Val Lys Glu Asp Lys Phe Lys 
                85                  90                  95      


Trp Asn Leu Thr Thr Arg Ser His His Gly Phe Lys Gly Met Trp Ser 
            100                 105                 110         


Cys Leu Glu Val Ala Glu Ala Cys Val Gly Asp Val Val Cys Asn Ala 
        115                 120                 125             


Gln Leu Ala Ser Tyr Leu Lys Ala Cys Ser Ala Asn Gly Asn Pro Cys 
    130                 135                 140                 


Asp Leu Lys Gln Cys Gln Ala Ala Ile Arg Phe Phe Tyr Gln Asn Ile 
145                 150                 155                 160 


Pro Phe Asn Ile Ala Gln Met Leu Ala Phe Cys Asp Cys Ala Gln Ser 
                165                 170                 175     


Asp Ile Pro Cys Gln Gln Ser Lys Glu Ala Leu His Ser Lys Thr Cys 
            180                 185                 190         


Ala Val Asn Met Val Pro Pro Pro Thr Cys Leu Ser Val Ile Arg Ser 
        195                 200                 205             


Cys Gln Asn Asp Glu Leu Cys Arg Arg His Tyr Arg Thr Phe Gln Ser 
    210                 215                 220                 


Lys Cys Trp Gln Arg Val Thr Arg Lys Cys His Glu Asp Glu Asn Cys 
225                 230                 235                 240 


Ile Ser Thr Leu Ser Lys Gln Asp Leu Thr Cys Ser Gly Ser Asp Asp 
                245                 250                 255     


Cys Lys Ala Ala Tyr Ile Asp Ile Leu Gly Thr Val Leu Gln Val Gln 
            260                 265                 270         


Cys Thr Cys Arg Thr Ile Thr Gln Ser Glu Glu Ser Leu Cys Lys Ile 
        275                 280                 285             


Phe Gln His Met Leu His Arg Lys Ser Cys Phe Asn Tyr Pro Thr Leu 
    290                 295                 300                 


Ser Asn Val Lys Gly Met Ala Leu Tyr Thr Arg Lys His Ala Asn Lys 
305                 310                 315                 320 


Ile Thr Leu Thr Gly Phe His Ser Pro Phe Asn Gly Glu Gly Gly Gly 
                325                 330                 335     


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Lys Thr His 
            340                 345                 350         


Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val 
        355                 360                 365             


Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 
    370                 375                 380                 


Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu 
385                 390                 395                 400 


Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 
                405                 410                 415     


Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser 
            420                 425                 430         


Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 
        435                 440                 445             


Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile 
    450                 455                 460                 


Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 
465                 470                 475                 480 


Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu 
                485                 490                 495     


Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 
            500                 505                 510         


Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser 
        515                 520                 525             


Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg 
    530                 535                 540                 


Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 
545                 550                 555                 560 


His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys Gly 
                565                 570                 575     


Gly Gly Ser His His His His His His 
            580                 585 


<210>  29
<211>  585
<212>  PRT
<213>  artificial

<220>
<223>  fusion protein

<400>  29

Ser Gln Thr Asn Asn Cys Thr Tyr Leu Arg Glu Gln Cys Leu His Asp 
1               5                   10                  15      


Ala Asn Gly Cys Lys His Ala Trp Arg Ile Met Glu Asp Ala Cys Asn 
            20                  25                  30          


Asp Ser Asp Pro Gly Asp Pro Cys Lys Met Asn Asn Ser Ser Tyr Cys 
        35                  40                  45              


Asn Leu Ser Ile Gln Tyr Leu Val Glu Ser Asn Phe Arg Phe Lys Glu 
    50                  55                  60                  


Cys Leu Cys Thr Asp Asp Phe Tyr Cys Thr Val Asn Lys Leu Leu Gly 
65                  70                  75                  80  


Lys Glu Cys Val Asn Lys Ser Asp Asn Met Arg Glu Asp Lys Phe Lys 
                85                  90                  95      


Trp Asn Leu Thr Thr His Ser His His Gly Phe Lys Gly Met Trp Ser 
            100                 105                 110         


Cys Leu Glu Val Ala Glu Ala Cys Val Gly Asp Val Val Cys Asn Ala 
        115                 120                 125             


Gln Leu Ala Ser Tyr Leu Lys Ala Cys Ser Ala Asn Gly Asn Pro Cys 
    130                 135                 140                 


Asp Val Lys His Cys Gln Ala Ala Ile Arg Phe Phe Tyr Gln Asn Ile 
145                 150                 155                 160 


Pro Phe Asn Ile Ala Gln Met Leu Ala Phe Cys Asp Cys Ser Gln Ser 
                165                 170                 175     


Asp Ile Pro Cys Gln Gln Ser Lys Glu Ala Leu His Ser Lys Pro Cys 
            180                 185                 190         


Ala Leu Asn Met Val Pro Pro Pro Thr Cys Leu Asn Val Ile Arg Ser 
        195                 200                 205             


Cys Gln Asn Asp Glu Leu Cys Arg Arg His Tyr Arg Thr Phe Gln Ser 
    210                 215                 220                 


Lys Cys Trp Gln Arg Val Thr Arg Lys Cys His Glu Asp Glu Asn Cys 
225                 230                 235                 240 


Ile Ser Ala Leu Ser Lys Gln Asp Leu Thr Cys Ser Gly Ser Asp Asp 
                245                 250                 255     


Cys Lys Ala Ala Tyr Ile Asp Ile Leu Gly Thr Val Leu Gln Val Gln 
            260                 265                 270         


Cys Asn Cys Arg Thr Ile Thr Gln Ser Glu Glu Ser Leu Cys Lys Ile 
        275                 280                 285             


Phe Gln His Met Leu His Arg Lys Ser Cys Phe Asn Tyr Pro Thr Leu 
    290                 295                 300                 


Ser Asn Val Lys Ser Met Ala Leu Tyr Thr Arg Lys His Thr Asn Lys 
305                 310                 315                 320 


Ile Thr Leu Thr Gly Phe Gln Ser Pro Phe Asn Gly Glu Gly Gly Gly 
                325                 330                 335     


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Lys Thr His 
            340                 345                 350         


Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val 
        355                 360                 365             


Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 
    370                 375                 380                 


Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu 
385                 390                 395                 400 


Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 
                405                 410                 415     


Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser 
            420                 425                 430         


Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 
        435                 440                 445             


Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile 
    450                 455                 460                 


Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 
465                 470                 475                 480 


Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu 
                485                 490                 495     


Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 
            500                 505                 510         


Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser 
        515                 520                 525             


Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg 
    530                 535                 540                 


Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 
545                 550                 555                 560 


His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys Gly 
                565                 570                 575     


Gly Gly Ser His His His His His His 
            580                 585 


<210>  30
<211>  394
<212>  PRT
<213>  cynomolgus monkey

<400>  30

Met Ile Val Leu Ile Phe Leu Ala Leu Gly Leu Ser Leu Glu Asn Glu 
1               5                   10                  15      


Tyr Thr Ser Gln Thr Asn Asn Cys Thr Tyr Leu Arg Glu Gln Cys Leu 
            20                  25                  30          


His Asp Ala Asn Gly Cys Lys His Ala Trp Arg Ile Met Glu Asp Ala 
        35                  40                  45              


Cys Asn Asp Ser Asp Pro Gly Asp Pro Cys Lys Met Asn Asn Ser Ser 
    50                  55                  60                  


Tyr Cys Asn Leu Ser Ile Gln Tyr Leu Val Glu Ser Asn Phe Arg Phe 
65                  70                  75                  80  


Lys Glu Cys Leu Cys Thr Asp Asp Phe Tyr Cys Thr Val Asn Lys Leu 
                85                  90                  95      


Leu Gly Lys Glu Cys Val Asn Lys Ser Asp Asn Met Arg Glu Asp Lys 
            100                 105                 110         


Phe Lys Trp Asn Leu Thr Thr His Ser His His Gly Phe Lys Gly Met 
        115                 120                 125             


Trp Ser Cys Leu Glu Val Ala Glu Ala Cys Val Gly Asp Val Val Cys 
    130                 135                 140                 


Asn Ala Gln Leu Ala Ser Tyr Leu Lys Ala Cys Ser Ala Asn Gly Asn 
145                 150                 155                 160 


Pro Cys Asp Val Lys His Cys Gln Ala Ala Ile Arg Phe Phe Tyr Gln 
                165                 170                 175     


Asn Ile Pro Phe Asn Ile Ala Gln Met Leu Ala Phe Cys Asp Cys Ser 
            180                 185                 190         


Gln Ser Asp Ile Pro Cys Gln Gln Ser Lys Glu Ala Leu His Ser Lys 
        195                 200                 205             


Pro Cys Ala Leu Asn Met Val Pro Pro Pro Thr Cys Leu Asn Val Ile 
    210                 215                 220                 


Arg Ser Cys Gln Asn Asp Glu Leu Cys Arg Arg His Tyr Arg Thr Phe 
225                 230                 235                 240 


Gln Ser Lys Cys Trp Gln Arg Val Thr Arg Lys Cys His Glu Asp Glu 
                245                 250                 255     


Asn Cys Ile Ser Ala Leu Ser Lys Gln Asp Leu Thr Cys Ser Gly Ser 
            260                 265                 270         


Asp Asp Cys Lys Ala Ala Tyr Ile Asp Ile Leu Gly Thr Val Leu Gln 
        275                 280                 285             


Val Gln Cys Asn Cys Arg Thr Ile Thr Gln Ser Glu Glu Ser Leu Cys 
    290                 295                 300                 


Lys Ile Phe Gln His Met Leu His Arg Lys Ser Cys Phe Asn Tyr Pro 
305                 310                 315                 320 


Thr Leu Ser Asn Val Lys Ser Met Ala Leu Tyr Thr Arg Lys His Thr 
                325                 330                 335     


Asn Lys Ile Thr Leu Thr Gly Phe Gln Ser Pro Phe Asn Gly Glu Val 
            340                 345                 350         


Ile Tyr Ala Ala Met Cys Met Thr Val Thr Cys Gly Ile Leu Leu Leu 
        355                 360                 365             


Val Met Val Lys Leu Arg Thr Ser Arg Ile Ser Ser Lys Ala Arg Asp 
    370                 375                 380                 


Pro Ser Leu Ser Gln Val Pro Gly Glu Leu 
385                 390                 


