                         SEQUENCE LISTING

<110>  Wellstat Ophthalmics Corporation
 
<120>  Fusion Protein Between Short Form Rod-Derived Cone Viability 
       Factor and a Hydrophilic Peptide

<130>  WOC-019PCT

<150>  US 62/406,552
<151>  2016-10-11

<160>  6     

<170>  PatentIn version 3.5

<210>  1
<211>  717
<212>  PRT
<213>  Homo sapiens


<220>
<221>  SIGNAL
<222>  (1)..(24)
<223>  Signal sequence from human albumin

<220>
<221>  MISC_FEATURE
<222>  (1)..(609)
<223>  Human albumin (including N-terminal signal peptide)

<220>
<221>  MISC_FEATURE
<222>  (25)..(609)
<223>  Human albumin (excluding N-terminal signal peptide)

<220>
<221>  MISC_FEATURE
<222>  (610)..(717)
<223>  RdCVFS

<400>  1

Met Lys Trp Val Thr Phe Ile Ser Leu Leu Phe Leu Phe Ser Ser Ala 
1               5                   10                  15      


Tyr Ser Arg Gly Val Phe Arg Arg Asp Ala His Lys Ser Glu Val Ala 
            20                  25                  30          


His Arg Phe Lys Asp Leu Gly Glu Glu Asn Phe Lys Ala Leu Val Leu 
        35                  40                  45              


Ile Ala Phe Ala Gln Tyr Leu Gln Gln Cys Pro Phe Glu Asp His Val 
    50                  55                  60                  


Lys Leu Val Asn Glu Val Thr Glu Phe Ala Lys Thr Cys Val Ala Asp 
65                  70                  75                  80  


Glu Ser Ala Glu Asn Cys Asp Lys Ser Leu His Thr Leu Phe Gly Asp 
                85                  90                  95      


Lys Leu Cys Thr Val Ala Thr Leu Arg Glu Thr Tyr Gly Glu Met Ala 
            100                 105                 110         


Asp Cys Cys Ala Lys Gln Glu Pro Glu Arg Asn Glu Cys Phe Leu Gln 
        115                 120                 125             


His Lys Asp Asp Asn Pro Asn Leu Pro Arg Leu Val Arg Pro Glu Val 
    130                 135                 140                 


Asp Val Met Cys Thr Ala Phe His Asp Asn Glu Glu Thr Phe Leu Lys 
145                 150                 155                 160 


Lys Tyr Leu Tyr Glu Ile Ala Arg Arg His Pro Tyr Phe Tyr Ala Pro 
                165                 170                 175     


Glu Leu Leu Phe Phe Ala Lys Arg Tyr Lys Ala Ala Phe Thr Glu Cys 
            180                 185                 190         


Cys Gln Ala Ala Asp Lys Ala Ala Cys Leu Leu Pro Lys Leu Asp Glu 
        195                 200                 205             


Leu Arg Asp Glu Gly Lys Ala Ser Ser Ala Lys Gln Arg Leu Lys Cys 
    210                 215                 220                 


Ala Ser Leu Gln Lys Phe Gly Glu Arg Ala Phe Lys Ala Trp Ala Val 
225                 230                 235                 240 


Ala Arg Leu Ser Gln Arg Phe Pro Lys Ala Glu Phe Ala Glu Val Ser 
                245                 250                 255     


Lys Leu Val Thr Asp Leu Thr Lys Val His Thr Glu Cys Cys His Gly 
            260                 265                 270         


Asp Leu Leu Glu Cys Ala Asp Asp Arg Ala Asp Leu Ala Lys Tyr Ile 
        275                 280                 285             


Cys Glu Asn Gln Asp Ser Ile Ser Ser Lys Leu Lys Glu Cys Cys Glu 
    290                 295                 300                 


Lys Pro Leu Leu Glu Lys Ser His Cys Ile Ala Glu Val Glu Asn Asp 
305                 310                 315                 320 


Glu Met Pro Ala Asp Leu Pro Ser Leu Ala Ala Asp Phe Val Glu Ser 
                325                 330                 335     


Lys Asp Val Cys Lys Asn Tyr Ala Glu Ala Lys Asp Val Phe Leu Gly 
            340                 345                 350         


Met Phe Leu Tyr Glu Tyr Ala Arg Arg His Pro Asp Tyr Ser Val Val 
        355                 360                 365             


Leu Leu Leu Arg Leu Ala Lys Thr Tyr Glu Thr Thr Leu Glu Lys Cys 
    370                 375                 380                 


Cys Ala Ala Ala Asp Pro His Glu Cys Tyr Ala Lys Val Phe Asp Glu 
385                 390                 395                 400 


Phe Lys Pro Leu Val Glu Glu Pro Gln Asn Leu Ile Lys Gln Asn Cys 
                405                 410                 415     


Glu Leu Phe Glu Gln Leu Gly Glu Tyr Lys Phe Gln Asn Ala Leu Leu 
            420                 425                 430         


Val Arg Tyr Thr Lys Lys Val Pro Gln Val Ser Thr Pro Thr Leu Val 
        435                 440                 445             


Glu Val Ser Arg Asn Leu Gly Lys Val Gly Ser Lys Cys Cys Lys His 
    450                 455                 460                 


Pro Glu Ala Lys Arg Met Pro Cys Ala Glu Asp Tyr Leu Ser Val Val 
465                 470                 475                 480 


Leu Asn Gln Leu Cys Val Leu His Glu Lys Thr Pro Val Ser Asp Arg 
                485                 490                 495     


Val Thr Lys Cys Cys Thr Glu Ser Leu Val Asn Arg Arg Pro Cys Phe 
            500                 505                 510         


Ser Ala Leu Glu Val Asp Glu Thr Tyr Val Pro Lys Glu Phe Asn Ala 
        515                 520                 525             


Glu Thr Phe Thr Phe His Ala Asp Ile Cys Thr Leu Ser Glu Lys Glu 
    530                 535                 540                 


Arg Gln Ile Lys Lys Gln Thr Ala Leu Val Glu Leu Val Lys His Lys 
545                 550                 555                 560 


Pro Lys Ala Thr Lys Glu Gln Leu Lys Ala Val Met Asp Asp Phe Ala 
                565                 570                 575     


Ala Phe Val Glu Lys Cys Cys Lys Ala Asp Asp Lys Glu Thr Cys Phe 
            580                 585                 590         


Ala Glu Glu Gly Lys Lys Leu Val Ala Ala Ser Gln Ala Ala Leu Gly 
        595                 600                 605             


Leu Ala Ser Leu Phe Ser Gly Arg Ile Leu Ile Arg Asn Asn Ser Asp 
    610                 615                 620                 


Gln Asp Glu Leu Asp Thr Glu Ala Glu Val Ser Arg Arg Leu Glu Asn 
625                 630                 635                 640 


Arg Leu Val Leu Leu Phe Phe Gly Ala Gly Ala Cys Pro Gln Cys Gln 
                645                 650                 655     


Ala Phe Val Pro Ile Leu Lys Asp Phe Phe Val Arg Leu Thr Asp Glu 
            660                 665                 670         


Phe Tyr Val Leu Arg Ala Ala Gln Leu Ala Leu Val Tyr Val Ser Gln 
        675                 680                 685             


Asp Ser Thr Glu Glu Gln Gln Asp Leu Phe Leu Lys Asp Met Pro Lys 
    690                 695                 700                 


Lys Trp Leu Phe Leu Pro Phe Glu Asp Asp Leu Arg Arg 
705                 710                 715         


<210>  2
<211>  2154
<212>  DNA
<213>  Homo sapiens

<400>  2
atgaagtggg taacctttat ttcccttctt tttctcttta gctcggctta ttccaggggt       60

gtgtttcgtc gagatgcaca caagagtgag gttgctcatc ggtttaaaga tttgggagaa      120

gaaaatttca aagccttggt gttgattgcc tttgctcagt atcttcagca gtgtccattt      180

gaagatcatg taaaattagt gaatgaagta actgaatttg caaaaacatg tgttgctgat      240

gagtcagctg aaaattgtga caaatcactt catacccttt ttggagacaa attatgcaca      300

gttgcaactc ttcgtgaaac ctatggtgaa atggctgact gctgtgcaaa acaagaacct      360

gagagaaatg aatgcttctt gcaacacaaa gatgacaacc caaacctccc ccgattggtg      420

agaccagagg ttgatgtgat gtgcactgct tttcatgaca atgaagagac atttttgaaa      480

aaatacttat atgaaattgc cagaagacat ccttactttt atgccccgga actccttttc      540

tttgctaaaa ggtataaagc tgcttttaca gaatgttgcc aagctgctga taaagctgcc      600

tgcctgttgc caaagctcga tgaacttcgg gatgaaggga aggcttcgtc tgccaaacag      660

agactcaagt gtgccagtct ccaaaaattt ggagaaagag ctttcaaagc atgggcagta      720

gctcgcctga gccagagatt tcccaaagct gagtttgcag aagtttccaa gttagtgaca      780

gatcttacca aagtccacac ggaatgctgc catggagatc tgcttgaatg tgctgatgac      840

agggcggacc ttgccaagta tatctgtgaa aatcaagatt cgatctccag taaactgaag      900

gaatgctgtg aaaaacctct gttggaaaaa tcccactgca ttgccgaagt ggaaaatgat      960

gagatgcctg ctgacttgcc ttcattagct gctgattttg ttgaaagtaa ggatgtttgc     1020

aaaaactatg ctgaggcaaa ggatgtcttc ctgggcatgt ttttgtatga atatgcaaga     1080

aggcatcctg attactctgt cgtgctgctg ctgagacttg ccaagacata tgaaaccact     1140

ctagagaagt gctgtgccgc tgcagatcct catgaatgct atgccaaagt gttcgatgaa     1200

tttaaacctc ttgtggaaga gcctcagaat ttaatcaaac aaaattgtga gctttttgag     1260

cagcttggag agtacaaatt ccagaatgcg ctattagttc gttacaccaa gaaagtaccc     1320

caagtgtcaa ctccaactct tgtagaggtc tcaagaaacc taggaaaagt gggcagcaaa     1380

tgttgtaaac atcctgaagc aaaaagaatg ccctgtgcag aagactatct atccgtggtc     1440

ctgaaccagt tatgtgtgtt gcatgagaaa acgccagtaa gtgacagagt caccaaatgc     1500

tgcacagaat ccttggtgaa caggcgacca tgcttttcag ctctggaagt cgatgaaaca     1560

tacgttccca aagagtttaa tgctgaaaca ttcaccttcc atgcagatat atgcacactt     1620

tctgagaagg agagacaaat caagaaacaa actgcacttg ttgagctcgt gaaacacaag     1680

cccaaggcaa caaaagagca actgaaagct gttatggatg atttcgcagc ttttgtagag     1740

aagtgctgca aggctgacga taaggagacc tgctttgccg aggagggtaa aaaacttgtt     1800

gctgcaagtc aagctgcctt aggcttagcc agcctgttca gcggccggat cctgatcagg     1860

aacaacagcg accaggacga gctggacacc gaggccgaag tgagcaggag gctggagaac     1920

agactggtgc tgctgttctt tggcgccgga gcctgccctc agtgccaggc cttcgtgccc     1980

atcctgaagg atttctttgt gcggctgacc gacgagttct acgtgctgag agccgcccag     2040

ctggccctgg tgtatgtgag ccaggacagc accgaggagc agcaggacct gttcctgaag     2100

gacatgccca agaagtggct gttcctgccc ttcgaggacg acctgcggag atga           2154


<210>  3
<211>  732
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  N-terminal signal sequence from mouse IgK, followed by spacer, 
       followed by RdCVFS, followed by spacer, followed by human albumin
       at C-terminus.


<220>
<221>  SIGNAL
<222>  (1)..(21)
<223>  Signal sequence from mouse Igk.

<220>
<221>  MISC_FEATURE
<222>  (22)..(35)
<223>  Spacer

<220>
<221>  MISC_FEATURE
<222>  (36)..(143)
<223>  RdCVFS

<220>
<221>  MISC_FEATURE
<222>  (144)..(147)
<223>  Spacer

<220>
<221>  MISC_FEATURE
<222>  (148)..(732)
<223>  Human albumin

<400>  3

Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly Asp Ala Ala Gln Pro Ala Arg Arg Ala Val Arg Ser 
            20                  25                  30          


Leu Val Pro Ala Ser Leu Phe Ser Gly Arg Ile Leu Ile Arg Asn Asn 
        35                  40                  45              


Ser Asp Gln Asp Glu Leu Asp Thr Glu Ala Glu Val Ser Arg Arg Leu 
    50                  55                  60                  


Glu Asn Arg Leu Val Leu Leu Phe Phe Gly Ala Gly Ala Cys Pro Gln 
65                  70                  75                  80  


Cys Gln Ala Phe Val Pro Ile Leu Lys Asp Phe Phe Val Arg Leu Thr 
                85                  90                  95      


Asp Glu Phe Tyr Val Leu Arg Ala Ala Gln Leu Ala Leu Val Tyr Val 
            100                 105                 110         


Ser Gln Asp Ser Thr Glu Glu Gln Gln Asp Leu Phe Leu Lys Asp Met 
        115                 120                 125             


Pro Lys Lys Trp Leu Phe Leu Pro Phe Glu Asp Asp Leu Arg Arg Gly 
    130                 135                 140                 


Arg Asp Ala Asp Ala His Lys Ser Glu Val Ala His Arg Phe Lys Asp 
145                 150                 155                 160 


Leu Gly Glu Glu Asn Phe Lys Ala Leu Val Leu Ile Ala Phe Ala Gln 
                165                 170                 175     


Tyr Leu Gln Gln Cys Pro Phe Glu Asp His Val Lys Leu Val Asn Glu 
            180                 185                 190         


Val Thr Glu Phe Ala Lys Thr Cys Val Ala Asp Glu Ser Ala Glu Asn 
        195                 200                 205             


Cys Asp Lys Ser Leu His Thr Leu Phe Gly Asp Lys Leu Cys Thr Val 
    210                 215                 220                 


Ala Thr Leu Arg Glu Thr Tyr Gly Glu Met Ala Asp Cys Cys Ala Lys 
225                 230                 235                 240 


Gln Glu Pro Glu Arg Asn Glu Cys Phe Leu Gln His Lys Asp Asp Asn 
                245                 250                 255     


Pro Asn Leu Pro Arg Leu Val Arg Pro Glu Val Asp Val Met Cys Thr 
            260                 265                 270         


Ala Phe His Asp Asn Glu Glu Thr Phe Leu Lys Lys Tyr Leu Tyr Glu 
        275                 280                 285             


Ile Ala Arg Arg His Pro Tyr Phe Tyr Ala Pro Glu Leu Leu Phe Phe 
    290                 295                 300                 


Ala Lys Arg Tyr Lys Ala Ala Phe Thr Glu Cys Cys Gln Ala Ala Asp 
305                 310                 315                 320 


Lys Ala Ala Cys Leu Leu Pro Lys Leu Asp Glu Leu Arg Asp Glu Gly 
                325                 330                 335     


Lys Ala Ser Ser Ala Lys Gln Arg Leu Lys Cys Ala Ser Leu Gln Lys 
            340                 345                 350         


Phe Gly Glu Arg Ala Phe Lys Ala Trp Ala Val Ala Arg Leu Ser Gln 
        355                 360                 365             


Arg Phe Pro Lys Ala Glu Phe Ala Glu Val Ser Lys Leu Val Thr Asp 
    370                 375                 380                 


Leu Thr Lys Val His Thr Glu Cys Cys His Gly Asp Leu Leu Glu Cys 
385                 390                 395                 400 


Ala Asp Asp Arg Ala Asp Leu Ala Lys Tyr Ile Cys Glu Asn Gln Asp 
                405                 410                 415     


Ser Ile Ser Ser Lys Leu Lys Glu Cys Cys Glu Lys Pro Leu Leu Glu 
            420                 425                 430         


Lys Ser His Cys Ile Ala Glu Val Glu Asn Asp Glu Met Pro Ala Asp 
        435                 440                 445             


Leu Pro Ser Leu Ala Ala Asp Phe Val Glu Ser Lys Asp Val Cys Lys 
    450                 455                 460                 


Asn Tyr Ala Glu Ala Lys Asp Val Phe Leu Gly Met Phe Leu Tyr Glu 
465                 470                 475                 480 


Tyr Ala Arg Arg His Pro Asp Tyr Ser Val Val Leu Leu Leu Arg Leu 
                485                 490                 495     


Ala Lys Thr Tyr Glu Thr Thr Leu Glu Lys Cys Cys Ala Ala Ala Asp 
            500                 505                 510         


Pro His Glu Cys Tyr Ala Lys Val Phe Asp Glu Phe Lys Pro Leu Val 
        515                 520                 525             


Glu Glu Pro Gln Asn Leu Ile Lys Gln Asn Cys Glu Leu Phe Glu Gln 
    530                 535                 540                 


Leu Gly Glu Tyr Lys Phe Gln Asn Ala Leu Leu Val Arg Tyr Thr Lys 
545                 550                 555                 560 


Lys Val Pro Gln Val Ser Thr Pro Thr Leu Val Glu Val Ser Arg Asn 
                565                 570                 575     


Leu Gly Lys Val Gly Ser Lys Cys Cys Lys His Pro Glu Ala Lys Arg 
            580                 585                 590         


Met Pro Cys Ala Glu Asp Tyr Leu Ser Val Val Leu Asn Gln Leu Cys 
        595                 600                 605             


Val Leu His Glu Lys Thr Pro Val Ser Asp Arg Val Thr Lys Cys Cys 
    610                 615                 620                 


Thr Glu Ser Leu Val Asn Arg Arg Pro Cys Phe Ser Ala Leu Glu Val 
625                 630                 635                 640 


Asp Glu Thr Tyr Val Pro Lys Glu Phe Asn Ala Glu Thr Phe Thr Phe 
                645                 650                 655     


His Ala Asp Ile Cys Thr Leu Ser Glu Lys Glu Arg Gln Ile Lys Lys 
            660                 665                 670         


Gln Thr Ala Leu Val Glu Leu Val Lys His Lys Pro Lys Ala Thr Lys 
        675                 680                 685             


Glu Gln Leu Lys Ala Val Met Asp Asp Phe Ala Ala Phe Val Glu Lys 
    690                 695                 700                 


Cys Cys Lys Ala Asp Asp Lys Glu Thr Cys Phe Ala Glu Glu Gly Lys 
705                 710                 715                 720 


Lys Leu Val Ala Ala Ser Gln Ala Ala Leu Gly Leu 
                725                 730         


<210>  4
<211>  2199
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  N-terminal signal sequence from mouse IgK, followed by spacer, 
       followed by RdCVFS, followed by spacer, followed by human albumin
       at C-terminus.

<400>  4
atggagacag acacactcct gctatgggta ctgctgctct gggttccagg ttccactggt       60

gacgcggccc agccggccag gcgcgccgta cgaagcttgg tacccgccag cctgttcagc      120

ggccggatcc tgatcaggaa caacagcgac caggacgagc tggacaccga ggccgaagtg      180

agcaggaggc tggagaacag actggtgctg ctgttctttg gcgccggagc ctgccctcag      240

tgccaggcct tcgtgcccat cctgaaggat ttctttgtgc ggctgaccga cgagttctac      300

gtgctgagag ccgcccagct ggccctggtg tatgtgagcc aggacagcac cgaggagcag      360

caggacctgt tcctgaagga catgcccaag aagtggctgt tcctgccctt cgaggacgac      420

ctgcggagag gacgagatgc agatgcacac aagagtgagg ttgctcatcg gtttaaagat      480

ttgggagaag aaaatttcaa agccttggtg ttgattgcct ttgctcagta tcttcagcag      540

tgtccatttg aagatcatgt aaaattagtg aatgaagtaa ctgaatttgc aaaaacatgt      600

gttgctgatg agtcagctga aaattgtgac aaatcacttc ataccctttt tggagacaaa      660

ttatgcacag ttgcaactct tcgtgaaacc tatggtgaaa tggctgactg ctgtgcaaaa      720

caagaacctg agagaaatga atgcttcttg caacacaaag atgacaaccc aaacctcccc      780

cgattggtga gaccagaggt tgatgtgatg tgcactgctt ttcatgacaa tgaagagaca      840

tttttgaaaa aatacttata tgaaattgcc agaagacatc cttactttta tgccccggaa      900

ctccttttct ttgctaaaag gtataaagct gcttttacag aatgttgcca agctgctgat      960

aaagctgcct gcctgttgcc aaagctcgat gaacttcggg atgaagggaa ggcttcgtct     1020

gccaaacaga gactcaagtg tgccagtctc caaaaatttg gagaaagagc tttcaaagca     1080

tgggcagtag ctcgcctgag ccagagattt cccaaagctg agtttgcaga agtttccaag     1140

ttagtgacag atcttaccaa agtccacacg gaatgctgcc atggagatct gcttgaatgt     1200

gctgatgaca gggcggacct tgccaagtat atctgtgaaa atcaagattc gatctccagt     1260

aaactgaagg aatgctgtga aaaacctctg ttggaaaaat cccactgcat tgccgaagtg     1320

gaaaatgatg agatgcctgc tgacttgcct tcattagctg ctgattttgt tgaaagtaag     1380

gatgtttgca aaaactatgc tgaggcaaag gatgtcttcc tgggcatgtt tttgtatgaa     1440

tatgcaagaa ggcatcctga ttactctgtc gtgctgctgc tgagacttgc caagacatat     1500

gaaaccactc tagagaagtg ctgtgccgct gcagatcctc atgaatgcta tgccaaagtg     1560

ttcgatgaat ttaaacctct tgtggaagag cctcagaatt taatcaaaca aaattgtgag     1620

ctttttgagc agcttggaga gtacaaattc cagaatgcgc tattagttcg ttacaccaag     1680

aaagtacccc aagtgtcaac tccaactctt gtagaggtct caagaaacct aggaaaagtg     1740

ggcagcaaat gttgtaaaca tcctgaagca aaaagaatgc cctgtgcaga agactatcta     1800

tccgtggtcc tgaaccagtt atgtgtgttg catgagaaaa cgccagtaag tgacagagtc     1860

accaaatgct gcacagaatc cttggtgaac aggcgaccat gcttttcagc tctggaagtc     1920

gatgaaacat acgttcccaa agagtttaat gctgaaacat tcaccttcca tgcagatata     1980

tgcacacttt ctgagaagga gagacaaatc aagaaacaaa ctgcacttgt tgagctcgtg     2040

aaacacaagc ccaaggcaac aaaagagcaa ctgaaagctg ttatggatga tttcgcagct     2100

tttgtagaga agtgctgcaa ggctgacgat aaggagacct gctttgccga ggagggtaaa     2160

aaacttgttg ctgcaagtca agctgcctta ggcttataa                            2199


<210>  5
<211>  109
<212>  PRT
<213>  Homo sapiens

<400>  5

Met Ala Ser Leu Phe Ser Gly Arg Ile Leu Ile Arg Asn Asn Ser Asp 
1               5                   10                  15      


Gln Asp Glu Leu Asp Thr Glu Ala Glu Val Ser Arg Arg Leu Glu Asn 
            20                  25                  30          


Arg Leu Val Leu Leu Phe Phe Gly Ala Gly Ala Cys Pro Gln Cys Gln 
        35                  40                  45              


Ala Phe Val Pro Ile Leu Lys Asp Phe Phe Val Arg Leu Thr Asp Glu 
    50                  55                  60                  


Phe Tyr Val Leu Arg Ala Ala Gln Leu Ala Leu Val Tyr Val Ser Gln 
65                  70                  75                  80  


Asp Ser Thr Glu Glu Gln Gln Asp Leu Phe Leu Lys Asp Met Pro Lys 
                85                  90                  95      


Lys Trp Leu Phe Leu Pro Phe Glu Asp Asp Leu Arg Arg 
            100                 105                 


<210>  6
<211>  212
<212>  PRT
<213>  Homo sapiens

<400>  6

Met Ala Ser Leu Phe Ser Gly Arg Ile Leu Ile Arg Asn Asn Ser Asp 
1               5                   10                  15      


Gln Asp Glu Leu Asp Thr Glu Ala Glu Val Ser Arg Arg Leu Glu Asn 
            20                  25                  30          


Arg Leu Val Leu Leu Phe Phe Gly Ala Gly Ala Cys Pro Gln Cys Gln 
        35                  40                  45              


Ala Phe Val Pro Ile Leu Lys Asp Phe Phe Val Arg Leu Thr Asp Glu 
    50                  55                  60                  


Phe Tyr Val Leu Arg Ala Ala Gln Leu Ala Leu Val Tyr Val Ser Gln 
65                  70                  75                  80  


Asp Ser Thr Glu Glu Gln Gln Asp Leu Phe Leu Lys Asp Met Pro Lys 
                85                  90                  95      


Lys Trp Leu Phe Leu Pro Phe Glu Asp Asp Leu Arg Arg Asp Leu Gly 
            100                 105                 110         


Arg Gln Phe Ser Val Glu Arg Leu Pro Ala Val Val Val Leu Lys Pro 
        115                 120                 125             


Asp Gly Asp Val Leu Thr Arg Asp Gly Ala Asp Glu Ile Gln Arg Leu 
    130                 135                 140                 


Gly Thr Ala Cys Phe Ala Asn Trp Gln Glu Ala Ala Glu Val Leu Asp 
145                 150                 155                 160 


Arg Asn Phe Gln Leu Pro Glu Asp Leu Glu Asp Gln Glu Pro Arg Ser 
                165                 170                 175     


Leu Thr Glu Cys Leu Arg Arg His Lys Tyr Arg Val Glu Lys Ala Ala 
            180                 185                 190         


Arg Gly Gly Arg Asp Pro Gly Gly Gly Gly Gly Glu Glu Gly Gly Ala 
        195                 200                 205             


Gly Gly Leu Phe 
    210         


