                         SEQUENCE LISTING

<110>  Integrated BioTherapeutics, Inc.
       The University of Maryland
       AMAN, Mohammad Javad
       HOWELL, Katie A
       HOLTSBERG, Frederick Wayne
       ZHAO, Xuelian
       LI, Yuxing
 
<120>  BROADLY NEUTRALIZING ANTIBODY TARGETING THE EBOLAVIRUS 
       GLYCOPROTEIN INTERNAL FUSION LOOP

<130>  57783-170243

<150>  62/406,598
<151>  2016-10-11

<160>  35    

<170>  PatentIn version 3.5

<210>  1
<211>  128
<212>  PRT
<213>  cynomolgus macaque

<400>  1

Gln Val Gln Leu Gln Glu Trp Gly Glu Gly Leu Val Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Ala Val Tyr Gly Gly Ser Ile Ser Gly Tyr 
            20                  25                  30          


Tyr His Trp Asn Trp Ile Arg Leu Pro Pro Gly Lys Gly Leu Glu Trp 
        35                  40                  45              


Ile Gly Asn Ile Asp Asn Ser Ala Ser Thr Asn Tyr Asn Pro Ser Leu 
    50                  55                  60                  


Lys Thr Arg Val Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Ile Ser 
65                  70                  75                  80  


Leu Lys Val Arg Ser Leu Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Pro Gly Phe Thr Ile Phe Gly Val Val Ile Thr Ser Trp 
            100                 105                 110         


Ser Gly Leu Asp Ser Trp Gly Gln Gly Ala Val Val Thr Val Ser Ser 
        115                 120                 125             


<210>  2
<211>  106
<212>  PRT
<213>  cynomolgus macaque

<400>  2

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Thr Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Asn Asn 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Arg Pro Arg Arg Ala Pro Gln Leu Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Asn Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Ala 
65                  70                  75                  80  


Glu Asp Phe Ala Ala Tyr Tyr Cys Gln Gln His Asn Thr Leu Pro Leu 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Val Glu Ile 
            100                 105     


<210>  3
<211>  6
<212>  PRT
<213>  cynomolgus macaque

<400>  3

Gly Tyr Tyr His Trp Asn 
1               5       


<210>  4
<211>  17
<212>  PRT
<213>  cynomolgus macaque

<400>  4

Gly Asn Ile Asp Asn Ser Ala Ser Thr Asn Tyr Asn Pro Ser Leu Lys 
1               5                   10                  15      


Thr 
    


<210>  5
<211>  19
<212>  PRT
<213>  cynomolgus macaque

<400>  5

Asp Pro Gly Phe Thr Ile Phe Gly Val Val Ile Thr Ser Trp Ser Gly 
1               5                   10                  15      


Leu Asp Ser 
            


<210>  6
<211>  11
<212>  PRT
<213>  cynomolgus macaque

<400>  6

Arg Ala Ser Gln Ser Ile Ser Asn Asn Leu Ala 
1               5                   10      


<210>  7
<211>  6
<212>  PRT
<213>  cynomolgus macaque

<400>  7

Ala Ala Ser Asn Leu Ala 
1               5       


<210>  8
<211>  9
<212>  PRT
<213>  cynomolgus macaque

<400>  8

Gln Gln His Asn Thr Leu Pro Leu Thr 
1               5                   


<210>  9
<211>  6
<212>  PRT
<213>  cynomolgus macaque


<220>
<221>  misc_feature
<222>  (1)..(6)
<223>  X is any amino acid

<400>  9

Gly Tyr Tyr Xaa Trp Xaa 
1               5       


<210>  10
<211>  19
<212>  PRT
<213>  cynomolgus macaque


<220>
<221>  misc_feature
<222>  (1)..(19)
<223>  X is any amino acid

<400>  10

Asp Xaa Gly Xaa Thr Ile Phe Xaa Xaa Xaa Ile Xaa Xaa Trp Xaa Xaa 
1               5                   10                  15      


Xaa Asp Xaa 
            


<210>  11
<211>  676
<212>  PRT
<213>  Ebola virus

<400>  11

Met Gly Val Thr Gly Ile Leu Gln Leu Pro Arg Asp Arg Phe Lys Arg 
1               5                   10                  15      


Thr Ser Phe Phe Leu Trp Val Ile Ile Leu Phe Gln Arg Thr Phe Ser 
            20                  25                  30          


Ile Pro Leu Gly Val Ile His Asn Ser Thr Leu Gln Val Ser Asp Val 
        35                  40                  45              


Asp Lys Leu Val Cys Arg Asp Lys Leu Ser Ser Thr Asn Gln Leu Arg 
    50                  55                  60                  


Ser Val Gly Leu Asn Leu Glu Gly Asn Gly Val Ala Thr Asp Val Pro 
65                  70                  75                  80  


Ser Val Thr Lys Arg Trp Gly Phe Arg Ser Gly Val Pro Pro Lys Val 
                85                  90                  95      


Val Asn Tyr Glu Ala Gly Glu Trp Ala Glu Asn Cys Tyr Asn Leu Glu 
            100                 105                 110         


Ile Lys Lys Pro Asp Gly Ser Glu Cys Leu Pro Ala Ala Pro Asp Gly 
        115                 120                 125             


Ile Arg Gly Phe Pro Arg Cys Arg Tyr Val His Lys Val Ser Gly Thr 
    130                 135                 140                 


Gly Pro Cys Ala Gly Asp Phe Ala Phe His Lys Glu Gly Ala Phe Phe 
145                 150                 155                 160 


Leu Tyr Asp Arg Leu Ala Ser Thr Val Ile Tyr Arg Gly Thr Thr Phe 
                165                 170                 175     


Ala Glu Gly Val Val Ala Phe Leu Ile Leu Pro Gln Ala Lys Lys Asp 
            180                 185                 190         


Phe Phe Ser Ser His Pro Leu Arg Glu Pro Val Asn Ala Thr Glu Asp 
        195                 200                 205             


Pro Ser Ser Gly Tyr Tyr Ser Thr Thr Ile Arg Tyr Gln Ala Thr Gly 
    210                 215                 220                 


Phe Gly Thr Asn Glu Thr Glu Tyr Leu Phe Glu Val Asp Asn Leu Thr 
225                 230                 235                 240 


Tyr Val Gln Leu Glu Ser Arg Phe Thr Pro Gln Phe Leu Leu Gln Leu 
                245                 250                 255     


Asn Glu Thr Ile Tyr Ala Ser Gly Lys Arg Ser Asn Thr Thr Gly Lys 
            260                 265                 270         


Leu Ile Trp Lys Val Asn Pro Glu Ile Asp Thr Thr Ile Gly Glu Trp 
        275                 280                 285             


Ala Phe Trp Glu Thr Lys Lys Asn Leu Thr Arg Lys Ile Arg Ser Glu 
    290                 295                 300                 


Glu Leu Ser Phe Thr Ala Val Ser Asn Gly Pro Lys Asn Ile Ser Gly 
305                 310                 315                 320 


Gln Ser Pro Ala Arg Thr Ser Ser Asp Pro Glu Thr Asn Thr Thr Asn 
                325                 330                 335     


Glu Asp His Lys Ile Met Ala Ser Glu Asn Ser Ser Ala Met Val Gln 
            340                 345                 350         


Val His Ser Gln Gly Arg Lys Ala Ala Val Ser His Leu Thr Thr Leu 
        355                 360                 365             


Ala Thr Ile Ser Thr Ser Pro Gln Pro Pro Thr Thr Lys Thr Gly Pro 
    370                 375                 380                 


Asp Asn Ser Thr His Asn Thr Pro Val Tyr Lys Leu Asp Ile Ser Glu 
385                 390                 395                 400 


Ala Thr Gln Val Gly Gln His His Arg Arg Ala Asp Asn Asp Ser Thr 
                405                 410                 415     


Ala Ser Asp Thr Pro Pro Ala Thr Thr Ala Ala Gly Pro Leu Lys Ala 
            420                 425                 430         


Glu Asn Thr Asn Thr Ser Lys Ser Ala Asp Ser Leu Asp Leu Ala Thr 
        435                 440                 445             


Thr Thr Ser Pro Gln Asn Tyr Ser Glu Thr Ala Gly Asn Asn Asn Thr 
    450                 455                 460                 


His His Gln Asp Thr Gly Glu Glu Ser Ala Ser Ser Gly Lys Leu Gly 
465                 470                 475                 480 


Leu Ile Thr Asn Thr Ile Ala Gly Val Ala Gly Leu Ile Thr Gly Gly 
                485                 490                 495     


Arg Arg Thr Arg Arg Glu Val Ile Val Asn Ala Gln Pro Lys Cys Asn 
            500                 505                 510         


Pro Asn Leu His Tyr Trp Thr Thr Gln Asp Glu Gly Ala Ala Ile Gly 
        515                 520                 525             


Leu Ala Trp Ile Pro Tyr Phe Gly Pro Ala Ala Glu Gly Ile Tyr Thr 
    530                 535                 540                 


Glu Gly Leu Met His Asn Gln Asp Gly Leu Ile Cys Gly Leu Arg Gln 
545                 550                 555                 560 


Leu Ala Asn Glu Thr Thr Gln Ala Leu Gln Leu Phe Leu Arg Ala Thr 
                565                 570                 575     


Thr Glu Leu Arg Thr Phe Ser Ile Leu Asn Arg Lys Ala Ile Asp Phe 
            580                 585                 590         


Leu Leu Gln Arg Trp Gly Gly Thr Cys His Ile Leu Gly Pro Asp Cys 
        595                 600                 605             


Cys Ile Glu Pro His Asp Trp Thr Lys Asn Ile Thr Asp Arg Ile Asp 
    610                 615                 620                 


Gln Ile Ile His Asp Phe Val Asp Lys Thr Leu Pro Asp Gln Gly Asp 
625                 630                 635                 640 


Asn Asp Asn Trp Trp Thr Gly Trp Arg Gln Trp Ile Pro Ala Gly Ile 
                645                 650                 655     


Gly Val Thr Gly Val Ile Ile Ala Val Ile Ala Leu Phe Cys Ile Cys 
            660                 665                 670         


Lys Phe Val Phe 
        675     


<210>  12
<211>  676
<212>  PRT
<213>  Ebola virus

<400>  12

Met Gly Val Thr Gly Ile Leu Gln Leu Pro Arg Asp Arg Phe Lys Arg 
1               5                   10                  15      


Thr Ser Phe Phe Leu Trp Val Ile Ile Leu Phe Gln Arg Thr Phe Ser 
            20                  25                  30          


Ile Pro Leu Gly Val Ile His Asn Ser Thr Leu Gln Val Ser Asp Val 
        35                  40                  45              


Asp Lys Leu Val Cys Arg Asp Lys Leu Ser Ser Thr Asn Gln Leu Arg 
    50                  55                  60                  


Ser Val Gly Leu Asn Leu Glu Gly Asn Gly Val Ala Thr Asp Val Pro 
65                  70                  75                  80  


Ser Ala Thr Lys Arg Trp Gly Phe Arg Ser Gly Val Pro Pro Lys Val 
                85                  90                  95      


Val Asn Tyr Glu Ala Gly Glu Trp Ala Glu Asn Cys Tyr Asn Leu Glu 
            100                 105                 110         


Ile Lys Lys Pro Asp Gly Ser Glu Cys Leu Pro Ala Ala Pro Asp Gly 
        115                 120                 125             


Ile Arg Gly Phe Pro Arg Cys Arg Tyr Val His Lys Val Ser Gly Thr 
    130                 135                 140                 


Gly Pro Cys Ala Gly Asp Phe Ala Phe His Lys Glu Gly Ala Phe Phe 
145                 150                 155                 160 


Leu Tyr Asp Arg Leu Ala Ser Thr Val Ile Tyr Arg Gly Thr Thr Phe 
                165                 170                 175     


Ala Glu Gly Val Val Ala Phe Leu Ile Leu Pro Gln Ala Lys Lys Asp 
            180                 185                 190         


Phe Phe Ser Ser His Pro Leu Arg Glu Pro Val Asn Ala Thr Glu Asp 
        195                 200                 205             


Pro Ser Ser Gly Tyr Tyr Ser Thr Thr Ile Arg Tyr Gln Ala Thr Gly 
    210                 215                 220                 


Phe Gly Thr Asn Glu Thr Glu Tyr Leu Phe Glu Val Asp Asn Leu Thr 
225                 230                 235                 240 


Tyr Val Gln Leu Glu Ser Arg Phe Thr Pro Gln Phe Leu Leu Gln Leu 
                245                 250                 255     


Asn Glu Thr Ile Tyr Thr Ser Gly Lys Arg Ser Asn Thr Thr Gly Lys 
            260                 265                 270         


Leu Ile Trp Lys Val Asn Pro Glu Ile Asp Thr Thr Ile Gly Glu Trp 
        275                 280                 285             


Ala Phe Trp Glu Thr Lys Lys Asn Leu Thr Arg Lys Ile Arg Ser Glu 
    290                 295                 300                 


Glu Leu Ser Phe Thr Val Val Ser Asn Gly Ala Lys Asn Ile Ser Gly 
305                 310                 315                 320 


Gln Ser Pro Ala Arg Thr Ser Ser Asp Pro Gly Thr Asn Thr Thr Thr 
                325                 330                 335     


Glu Asp His Lys Ile Met Ala Ser Glu Asn Ser Ser Ala Met Val Gln 
            340                 345                 350         


Val His Ser Gln Gly Arg Glu Ala Ala Val Ser His Leu Thr Thr Leu 
        355                 360                 365             


Ala Thr Ile Ser Thr Ser Pro Gln Ser Leu Thr Thr Lys Pro Gly Pro 
    370                 375                 380                 


Asp Asn Ser Thr His Asn Thr Pro Val Tyr Lys Leu Asp Ile Ser Glu 
385                 390                 395                 400 


Ala Thr Gln Val Glu Gln His His Arg Arg Thr Asp Asn Asp Ser Thr 
                405                 410                 415     


Ala Ser Asp Thr Pro Ser Ala Thr Thr Ala Ala Gly Pro Pro Lys Ala 
            420                 425                 430         


Glu Asn Thr Asn Thr Ser Lys Ser Thr Asp Phe Leu Asp Pro Ala Thr 
        435                 440                 445             


Thr Thr Ser Pro Gln Asn His Ser Glu Thr Ala Gly Asn Asn Asn Thr 
    450                 455                 460                 


His His Gln Asp Thr Gly Glu Glu Ser Ala Ser Ser Gly Lys Leu Gly 
465                 470                 475                 480 


Leu Ile Thr Asn Thr Ile Ala Gly Val Ala Gly Leu Ile Thr Gly Gly 
                485                 490                 495     


Arg Arg Thr Arg Arg Glu Ala Ile Val Asn Ala Gln Pro Lys Cys Asn 
            500                 505                 510         


Pro Asn Leu His Tyr Trp Thr Thr Gln Asp Glu Gly Ala Ala Ile Gly 
        515                 520                 525             


Leu Ala Trp Ile Pro Tyr Phe Gly Pro Ala Ala Glu Gly Ile Tyr Ile 
    530                 535                 540                 


Glu Gly Leu Met His Asn Gln Asp Gly Leu Ile Cys Gly Leu Arg Gln 
545                 550                 555                 560 


Leu Ala Asn Glu Thr Thr Gln Ala Leu Gln Leu Phe Leu Arg Ala Thr 
                565                 570                 575     


Thr Glu Leu Arg Thr Phe Ser Ile Leu Asn Arg Lys Ala Ile Asp Phe 
            580                 585                 590         


Leu Leu Gln Arg Trp Gly Gly Thr Cys His Ile Leu Gly Pro Asp Cys 
        595                 600                 605             


Cys Ile Glu Pro His Asp Trp Thr Lys Asn Ile Thr Asp Lys Ile Asp 
    610                 615                 620                 


Gln Ile Ile His Asp Phe Val Asp Lys Thr Leu Pro Asp Gln Gly Asp 
625                 630                 635                 640 


Asn Asp Asn Trp Trp Thr Gly Trp Arg Gln Trp Ile Pro Ala Gly Ile 
                645                 650                 655     


Gly Val Thr Gly Val Ile Ile Ala Val Ile Ala Leu Phe Cys Ile Cys 
            660                 665                 670         


Lys Phe Val Phe 
        675     


<210>  13
<211>  676
<212>  PRT
<213>  Ebola virus

<400>  13

Met Gly Val Thr Gly Ile Leu Gln Leu Pro Arg Asp Arg Phe Lys Arg 
1               5                   10                  15      


Thr Ser Phe Phe Leu Trp Val Ile Ile Leu Phe Gln Arg Thr Phe Ser 
            20                  25                  30          


Ile Pro Leu Gly Val Ile His Asn Ser Thr Leu Gln Val Ser Asp Val 
        35                  40                  45              


Asp Lys Leu Val Cys Arg Asp Lys Leu Ser Ser Thr Asn Gln Leu Arg 
    50                  55                  60                  


Ser Val Gly Leu Asn Leu Glu Gly Asn Gly Val Ala Thr Asp Val Pro 
65                  70                  75                  80  


Ser Ala Thr Lys Arg Trp Gly Phe Arg Ser Gly Val Pro Pro Lys Val 
                85                  90                  95      


Val Asn Tyr Glu Ala Gly Glu Trp Ala Glu Asn Cys Tyr Asn Leu Glu 
            100                 105                 110         


Ile Lys Lys Pro Asp Gly Ser Glu Cys Leu Pro Ala Ala Pro Asp Gly 
        115                 120                 125             


Ile Arg Gly Phe Pro Arg Cys Arg Tyr Val His Lys Val Ser Gly Thr 
    130                 135                 140                 


Gly Pro Cys Ala Gly Asp Phe Ala Phe His Lys Glu Gly Ala Phe Phe 
145                 150                 155                 160 


Leu Tyr Asp Arg Leu Ala Ser Thr Val Ile Tyr Arg Gly Thr Thr Phe 
                165                 170                 175     


Ala Glu Gly Val Val Ala Phe Leu Ile Leu Pro Gln Ala Lys Lys Asp 
            180                 185                 190         


Phe Phe Ser Ser His Pro Leu Arg Glu Pro Val Asn Ala Thr Glu Asp 
        195                 200                 205             


Pro Ser Ser Gly Tyr Tyr Ser Thr Thr Ile Arg Tyr Gln Ala Thr Gly 
    210                 215                 220                 


Phe Gly Thr Asn Glu Thr Glu Tyr Leu Phe Glu Val Asp Asn Leu Thr 
225                 230                 235                 240 


Tyr Val Gln Leu Glu Ser Arg Phe Thr Pro Gln Phe Leu Leu Gln Leu 
                245                 250                 255     


Asn Glu Thr Ile Tyr Thr Ser Gly Lys Arg Ser Asn Thr Thr Gly Lys 
            260                 265                 270         


Leu Ile Trp Lys Val Asn Pro Glu Ile Asp Thr Thr Ile Gly Glu Trp 
        275                 280                 285             


Ala Phe Trp Glu Thr Lys Lys Asn Leu Thr Arg Lys Ile Arg Ser Glu 
    290                 295                 300                 


Glu Leu Ser Phe Thr Ala Val Ser Asn Arg Ala Lys Asn Ile Ser Gly 
305                 310                 315                 320 


Gln Ser Pro Ala Arg Thr Ser Ser Asp Pro Gly Thr Asn Thr Thr Thr 
                325                 330                 335     


Glu Asp His Lys Ile Met Ala Ser Glu Asn Ser Ser Ala Met Val Gln 
            340                 345                 350         


Val His Ser Gln Gly Arg Glu Ala Ala Val Ser His Leu Thr Thr Leu 
        355                 360                 365             


Ala Thr Ile Ser Thr Ser Pro Gln Pro Pro Thr Thr Lys Pro Gly Pro 
    370                 375                 380                 


Asp Asn Ser Thr His Asn Thr Pro Val Tyr Lys Leu Asp Ile Ser Glu 
385                 390                 395                 400 


Ala Thr Gln Val Glu Gln His His Arg Arg Thr Asp Asn Asp Ser Thr 
                405                 410                 415     


Ala Ser Asp Thr Pro Pro Ala Thr Thr Ala Ala Gly Pro Leu Lys Ala 
            420                 425                 430         


Glu Asn Thr Asn Thr Ser Lys Gly Thr Asp Leu Leu Asp Pro Ala Thr 
        435                 440                 445             


Thr Thr Ser Pro Gln Asn His Ser Glu Thr Ala Gly Asn Asn Asn Thr 
    450                 455                 460                 


His His Gln Asp Thr Gly Glu Glu Ser Ala Ser Ser Gly Lys Leu Gly 
465                 470                 475                 480 


Leu Ile Thr Asn Thr Ile Ala Gly Val Ala Gly Leu Ile Thr Gly Gly 
                485                 490                 495     


Arg Arg Ala Arg Arg Glu Ala Ile Val Asn Ala Gln Pro Lys Cys Asn 
            500                 505                 510         


Pro Asn Leu His Tyr Trp Thr Thr Gln Asp Glu Gly Ala Ala Ile Gly 
        515                 520                 525             


Leu Ala Trp Ile Pro Tyr Phe Gly Pro Ala Ala Glu Gly Ile Tyr Ile 
    530                 535                 540                 


Glu Gly Leu Met His Asn Gln Asp Gly Leu Ile Cys Gly Leu Arg Gln 
545                 550                 555                 560 


Leu Ala Asn Glu Thr Thr Gln Ala Leu Gln Leu Phe Leu Arg Ala Thr 
                565                 570                 575     


Thr Glu Leu Arg Thr Phe Ser Ile Leu Asn Arg Lys Ala Ile Asp Phe 
            580                 585                 590         


Leu Leu Gln Arg Trp Gly Gly Thr Cys His Ile Leu Gly Pro Asp Cys 
        595                 600                 605             


Cys Ile Glu Pro His Asp Trp Thr Lys Asn Ile Thr Asp Lys Ile Asp 
    610                 615                 620                 


Gln Ile Ile His Asp Phe Val Asp Lys Thr Leu Pro Asp Gln Gly Asp 
625                 630                 635                 640 


Asn Asp Asn Trp Trp Thr Gly Trp Arg Gln Trp Ile Pro Ala Gly Ile 
                645                 650                 655     


Gly Val Thr Gly Val Ile Ile Ala Val Ile Ala Leu Phe Cys Ile Cys 
            660                 665                 670         


Lys Phe Val Phe 
        675     


<210>  14
<211>  676
<212>  PRT
<213>  Ebola virus

<400>  14

Met Gly Gly Leu Ser Leu Leu Gln Leu Pro Arg Asp Lys Phe Arg Lys 
1               5                   10                  15      


Ser Ser Phe Phe Val Trp Val Ile Ile Leu Phe Gln Lys Ala Phe Ser 
            20                  25                  30          


Met Pro Leu Gly Val Val Thr Asn Ser Thr Leu Glu Val Thr Glu Ile 
        35                  40                  45              


Asp Gln Leu Val Cys Lys Asp His Leu Ala Ser Thr Asp Gln Leu Lys 
    50                  55                  60                  


Ser Val Gly Leu Asn Leu Glu Gly Ser Gly Val Ser Thr Asp Ile Pro 
65                  70                  75                  80  


Ser Ala Thr Lys Arg Trp Gly Phe Arg Ser Gly Val Pro Pro Lys Val 
                85                  90                  95      


Val Ser Tyr Glu Ala Gly Glu Trp Ala Glu Asn Cys Tyr Asn Leu Glu 
            100                 105                 110         


Ile Lys Lys Pro Asp Gly Ser Glu Cys Leu Pro Pro Pro Pro Asp Gly 
        115                 120                 125             


Val Arg Gly Phe Pro Arg Cys Arg Tyr Val His Lys Ala Gln Gly Thr 
    130                 135                 140                 


Gly Pro Cys Pro Gly Asp Tyr Ala Phe His Lys Asp Gly Ala Phe Phe 
145                 150                 155                 160 


Leu Tyr Asp Arg Leu Ala Ser Thr Val Ile Tyr Arg Gly Val Asn Phe 
                165                 170                 175     


Ala Glu Gly Val Ile Ala Phe Leu Ile Leu Ala Lys Pro Lys Glu Thr 
            180                 185                 190         


Phe Leu Gln Ser Pro Pro Ile Arg Glu Ala Val Asn Tyr Thr Glu Asn 
        195                 200                 205             


Thr Ser Ser Tyr Tyr Ala Thr Ser Tyr Leu Glu Tyr Glu Ile Glu Asn 
    210                 215                 220                 


Phe Gly Ala Gln His Ser Thr Thr Leu Phe Lys Ile Asp Asn Asn Thr 
225                 230                 235                 240 


Phe Val Arg Leu Asp Arg Pro His Thr Pro Gln Phe Leu Phe Gln Leu 
                245                 250                 255     


Asn Asp Thr Ile His Leu His Gln Gln Leu Ser Asn Thr Thr Gly Arg 
            260                 265                 270         


Leu Ile Trp Thr Leu Asp Ala Asn Ile Asn Ala Asp Ile Gly Glu Trp 
        275                 280                 285             


Ala Phe Trp Glu Asn Lys Lys Asn Leu Ser Glu Gln Leu Arg Gly Glu 
    290                 295                 300                 


Glu Leu Ser Phe Glu Ala Leu Ser Leu Asn Glu Thr Glu Asp Asp Asp 
305                 310                 315                 320 


Ala Ala Ser Ser Arg Ile Thr Lys Gly Arg Ile Ser Asp Arg Ala Thr 
                325                 330                 335     


Arg Lys Tyr Ser Asp Leu Val Pro Lys Asn Ser Pro Gly Met Val Pro 
            340                 345                 350         


Leu His Ile Pro Glu Gly Glu Thr Thr Leu Pro Ser Gln Asn Ser Thr 
        355                 360                 365             


Glu Gly Arg Arg Val Gly Val Asn Thr Gln Glu Thr Ile Thr Glu Thr 
    370                 375                 380                 


Ala Ala Thr Ile Ile Gly Thr Asn Gly Asn His Met Gln Ile Ser Thr 
385                 390                 395                 400 


Ile Gly Ile Arg Pro Ser Ser Ser Gln Ile Pro Ser Ser Ser Pro Thr 
                405                 410                 415     


Thr Ala Pro Ser Pro Glu Ala Gln Thr Pro Thr Thr His Thr Ser Gly 
            420                 425                 430         


Pro Ser Val Met Ala Thr Glu Glu Pro Thr Thr Pro Pro Gly Ser Ser 
        435                 440                 445             


Pro Gly Pro Thr Thr Glu Ala Pro Thr Leu Thr Thr Pro Glu Asn Ile 
    450                 455                 460                 


Thr Thr Ala Val Lys Thr Val Leu Pro Gln Glu Ser Thr Ser Asn Gly 
465                 470                 475                 480 


Leu Ile Thr Ser Thr Val Thr Gly Ile Leu Gly Ser Leu Gly Leu Arg 
                485                 490                 495     


Lys Arg Ser Arg Arg Gln Thr Asn Thr Lys Ala Thr Gly Lys Cys Asn 
            500                 505                 510         


Pro Asn Leu His Tyr Trp Thr Ala Gln Glu Gln His Asn Ala Ala Gly 
        515                 520                 525             


Ile Ala Trp Ile Pro Tyr Phe Gly Pro Gly Ala Glu Gly Ile Tyr Thr 
    530                 535                 540                 


Glu Gly Leu Met His Asn Gln Asn Ala Leu Val Cys Gly Leu Arg Gln 
545                 550                 555                 560 


Leu Ala Asn Glu Thr Thr Gln Ala Leu Gln Leu Phe Leu Arg Ala Thr 
                565                 570                 575     


Thr Glu Leu Arg Thr Tyr Thr Ile Leu Asn Arg Lys Ala Ile Asp Phe 
            580                 585                 590         


Leu Leu Arg Arg Trp Gly Gly Thr Cys Arg Ile Leu Gly Pro Asp Cys 
        595                 600                 605             


Cys Ile Glu Pro His Asp Trp Thr Lys Asn Ile Thr Asp Lys Ile Asn 
    610                 615                 620                 


Gln Ile Ile His Asp Phe Ile Asp Asn Pro Leu Pro Asn Gln Asp Asn 
625                 630                 635                 640 


Asp Asp Asn Trp Trp Thr Gly Trp Arg Gln Trp Ile Pro Ala Gly Ile 
                645                 650                 655     


Gly Ile Thr Gly Ile Ile Ile Ala Ile Ile Ala Leu Leu Cys Val Cys 
            660                 665                 670         


Lys Leu Leu Cys 
        675     


<210>  15
<211>  676
<212>  PRT
<213>  Ebola virus

<400>  15

Met Val Thr Ser Gly Ile Leu Gln Leu Pro Arg Glu Arg Phe Arg Lys 
1               5                   10                  15      


Thr Ser Phe Phe Val Trp Val Ile Ile Leu Phe His Lys Val Phe Pro 
            20                  25                  30          


Ile Pro Leu Gly Val Val His Asn Asn Thr Leu Gln Val Ser Asp Ile 
        35                  40                  45              


Asp Lys Leu Val Cys Arg Asp Lys Leu Ser Ser Thr Ser Gln Leu Lys 
    50                  55                  60                  


Ser Val Gly Leu Asn Leu Glu Gly Asn Gly Val Ala Thr Asp Val Pro 
65                  70                  75                  80  


Thr Ala Thr Lys Arg Trp Gly Phe Arg Ala Gly Val Pro Pro Lys Val 
                85                  90                  95      


Val Asn Tyr Glu Ala Gly Glu Trp Ala Glu Asn Cys Tyr Asn Leu Asp 
            100                 105                 110         


Ile Lys Lys Ala Asp Gly Ser Glu Cys Leu Pro Glu Ala Pro Glu Gly 
        115                 120                 125             


Val Arg Gly Phe Pro Arg Cys Arg Tyr Val His Lys Val Ser Gly Thr 
    130                 135                 140                 


Gly Pro Cys Pro Glu Gly Phe Ala Phe His Lys Glu Gly Ala Phe Phe 
145                 150                 155                 160 


Leu Tyr Asp Arg Leu Ala Ser Thr Ile Ile Tyr Arg Ser Thr Thr Phe 
                165                 170                 175     


Ser Glu Gly Val Val Ala Phe Leu Ile Leu Pro Lys Thr Lys Lys Asp 
            180                 185                 190         


Phe Phe Gln Ser Pro Pro Leu His Glu Pro Ala Asn Met Thr Thr Asp 
        195                 200                 205             


Pro Ser Ser Tyr Tyr His Thr Val Thr Leu Asn Tyr Val Ala Asp Asn 
    210                 215                 220                 


Phe Gly Thr Asn Met Thr Asn Phe Leu Phe Gln Val Asp His Leu Thr 
225                 230                 235                 240 


Tyr Val Gln Leu Glu Pro Arg Phe Thr Pro Gln Phe Leu Val Gln Leu 
                245                 250                 255     


Asn Glu Thr Ile Tyr Thr Asn Gly Arg Arg Ser Asn Thr Thr Gly Thr 
            260                 265                 270         


Leu Ile Trp Lys Val Asn Pro Thr Val Asp Thr Gly Val Gly Glu Trp 
        275                 280                 285             


Ala Phe Trp Glu Asn Lys Lys Asn Phe Thr Lys Thr Leu Ser Ser Glu 
    290                 295                 300                 


Glu Leu Ser Val Ile Leu Val Pro Arg Ala Gln Asp Pro Gly Ser Asn 
305                 310                 315                 320 


Gln Lys Thr Lys Val Thr Pro Thr Ser Phe Ala Asn Asn Gln Thr Ser 
                325                 330                 335     


Lys Asn His Glu Asp Leu Val Pro Lys Asp Pro Ala Ser Val Val Gln 
            340                 345                 350         


Val Arg Asp Leu Gln Arg Glu Asn Thr Val Pro Thr Ser Pro Leu Asn 
        355                 360                 365             


Thr Val Pro Thr Thr Leu Ile Pro Asp Thr Met Glu Glu Gln Thr Thr 
    370                 375                 380                 


Ser His Tyr Glu Leu Pro Asn Ile Ser Gly Asn His Gln Glu Arg Asn 
385                 390                 395                 400 


Asn Thr Ala His Pro Glu Thr Leu Ala Asn Asn Pro Pro Asp Asn Thr 
                405                 410                 415     


Thr Pro Ser Thr Pro Pro Gln Asp Gly Glu Arg Thr Ser Ser His Thr 
            420                 425                 430         


Thr Pro Ser Pro Arg Pro Val Pro Thr Ser Thr Ile His Pro Thr Thr 
        435                 440                 445             


Arg Glu Thr Gln Ile Pro Thr Thr Met Ile Thr Ser His Asp Thr Asp 
    450                 455                 460                 


Ser Asn Arg Pro Asn Pro Ile Asp Ile Ser Glu Ser Thr Glu Pro Gly 
465                 470                 475                 480 


Leu Leu Thr Asn Thr Ile Arg Gly Val Ala Asn Leu Leu Thr Gly Ser 
                485                 490                 495     


Arg Arg Thr Arg Arg Glu Ile Thr Leu Arg Thr Gln Ala Lys Cys Asn 
            500                 505                 510         


Pro Asn Leu His Tyr Trp Thr Thr Gln Asp Glu Gly Ala Ala Ile Gly 
        515                 520                 525             


Leu Ala Trp Ile Pro Tyr Phe Gly Pro Ala Ala Glu Gly Ile Tyr Thr 
    530                 535                 540                 


Glu Gly Ile Met His Asn Gln Asn Gly Leu Ile Cys Gly Leu Arg Gln 
545                 550                 555                 560 


Leu Ala Asn Glu Thr Thr Gln Ala Leu Gln Leu Phe Leu Arg Ala Thr 
                565                 570                 575     


Thr Glu Leu Arg Thr Phe Ser Ile Leu Asn Arg Lys Ala Ile Asp Phe 
            580                 585                 590         


Leu Leu Gln Arg Trp Gly Gly Thr Cys His Ile Leu Gly Pro Asp Cys 
        595                 600                 605             


Cys Ile Glu Pro His Asp Trp Thr Lys Asn Ile Thr Asp Lys Ile Asp 
    610                 615                 620                 


Gln Ile Ile His Asp Phe Ile Asp Lys Pro Leu Pro Asp Gln Thr Asp 
625                 630                 635                 640 


Asn Asp Asn Trp Trp Thr Gly Trp Arg Gln Trp Val Pro Ala Gly Ile 
                645                 650                 655     


Gly Ile Thr Gly Val Ile Ile Ala Val Ile Ala Leu Leu Cys Ile Cys 
            660                 665                 670         


Lys Phe Leu Leu 
        675     


<210>  16
<211>  676
<212>  PRT
<213>  Ebola virus

<400>  16

Met Gly Ala Ser Gly Ile Leu Gln Leu Pro Arg Glu Arg Phe Arg Lys 
1               5                   10                  15      


Thr Ser Phe Phe Val Trp Val Ile Ile Leu Phe His Lys Val Phe Ser 
            20                  25                  30          


Ile Pro Leu Gly Val Val His Asn Asn Thr Leu Gln Val Ser Asp Ile 
        35                  40                  45              


Asp Lys Phe Val Cys Arg Asp Lys Leu Ser Ser Thr Ser Gln Leu Lys 
    50                  55                  60                  


Ser Val Gly Leu Asn Leu Glu Gly Asn Gly Val Ala Thr Asp Val Pro 
65                  70                  75                  80  


Thr Ala Thr Lys Arg Trp Gly Phe Arg Ala Gly Val Pro Pro Lys Val 
                85                  90                  95      


Val Asn Cys Glu Ala Gly Glu Trp Ala Glu Asn Cys Tyr Asn Leu Ala 
            100                 105                 110         


Ile Lys Lys Val Asp Gly Ser Glu Cys Leu Pro Glu Ala Pro Glu Gly 
        115                 120                 125             


Val Arg Asp Phe Pro Arg Cys Arg Tyr Val His Lys Val Ser Gly Thr 
    130                 135                 140                 


Gly Pro Cys Pro Gly Gly Leu Ala Phe His Lys Glu Gly Ala Phe Phe 
145                 150                 155                 160 


Leu Tyr Asp Arg Leu Ala Ser Thr Ile Ile Tyr Arg Gly Thr Thr Phe 
                165                 170                 175     


Ala Glu Gly Val Ile Ala Phe Leu Ile Leu Pro Lys Ala Arg Lys Asp 
            180                 185                 190         


Phe Phe Gln Ser Pro Pro Leu His Glu Pro Ala Asn Met Thr Thr Asp 
        195                 200                 205             


Pro Ser Ser Tyr Tyr His Thr Thr Thr Ile Asn Tyr Val Val Asp Asn 
    210                 215                 220                 


Phe Gly Thr Asn Thr Thr Glu Phe Leu Phe Gln Val Asp His Leu Thr 
225                 230                 235                 240 


Tyr Val Gln Leu Glu Ala Arg Phe Thr Pro Gln Phe Leu Val Leu Leu 
                245                 250                 255     


Asn Glu Thr Ile Tyr Ser Asp Asn Arg Arg Ser Asn Thr Thr Gly Lys 
            260                 265                 270         


Leu Ile Trp Lys Ile Asn Pro Thr Val Asp Thr Ser Met Gly Glu Trp 
        275                 280                 285             


Ala Phe Trp Glu Asn Lys Lys Asn Phe Thr Lys Thr Leu Ser Ser Glu 
    290                 295                 300                 


Glu Leu Ser Phe Val Pro Val Pro Glu Thr Gln Asn Gln Val Leu Asp 
305                 310                 315                 320 


Thr Thr Ala Thr Val Ser Pro Pro Ile Ser Ala His Asn His Ala Ala 
                325                 330                 335     


Glu Asp His Lys Glu Leu Val Ser Glu Asp Ser Thr Pro Val Val Gln 
            340                 345                 350         


Met Gln Asn Ile Lys Gly Lys Asp Thr Met Pro Thr Thr Val Thr Gly 
        355                 360                 365             


Val Pro Thr Thr Thr Pro Ser Pro Phe Pro Ile Asn Ala Arg Asn Thr 
    370                 375                 380                 


Asp His Thr Lys Ser Phe Ile Gly Leu Glu Gly Pro Gln Glu Asp His 
385                 390                 395                 400 


Ser Thr Thr Gln Pro Ala Lys Thr Thr Ser Gln Pro Thr Asn Ser Thr 
                405                 410                 415     


Glu Ser Thr Thr Leu Asn Pro Thr Ser Glu Pro Ser Ser Arg Gly Thr 
            420                 425                 430         


Gly Pro Ser Ser Pro Thr Val Pro Asn Thr Thr Glu Ser His Ala Glu 
        435                 440                 445             


Leu Gly Lys Thr Thr Pro Thr Thr Leu Pro Glu Gln His Thr Ala Ala 
    450                 455                 460                 


Ser Ala Ile Pro Arg Ala Val His Pro Asp Glu Leu Ser Gly Pro Gly 
465                 470                 475                 480 


Phe Leu Thr Asn Thr Ile Arg Gly Val Thr Asn Leu Leu Thr Gly Ser 
                485                 490                 495     


Arg Arg Lys Arg Arg Asp Val Thr Pro Asn Thr Gln Pro Lys Cys Asn 
            500                 505                 510         


Pro Asn Leu His Tyr Trp Thr Ala Leu Asp Glu Gly Ala Ala Ile Gly 
        515                 520                 525             


Leu Ala Trp Ile Pro Tyr Phe Gly Pro Ala Ala Glu Gly Ile Tyr Thr 
    530                 535                 540                 


Glu Gly Ile Met Glu Asn Gln Asn Gly Leu Ile Cys Gly Leu Arg Gln 
545                 550                 555                 560 


Leu Ala Asn Glu Thr Thr Gln Ala Leu Gln Leu Phe Leu Arg Ala Thr 
                565                 570                 575     


Thr Glu Leu Arg Thr Phe Ser Ile Leu Asn Arg Lys Ala Ile Asp Phe 
            580                 585                 590         


Leu Leu Gln Arg Trp Gly Gly Thr Cys His Ile Leu Gly Pro Asp Cys 
        595                 600                 605             


Cys Ile Glu Pro Gln Asp Trp Thr Lys Asn Ile Thr Asp Lys Ile Asp 
    610                 615                 620                 


Gln Ile Ile His Asp Phe Val Asp Asn Asn Leu Pro Asn Gln Asn Asp 
625                 630                 635                 640 


Gly Ser Asn Trp Trp Thr Gly Trp Lys Gln Trp Val Pro Ala Gly Ile 
                645                 650                 655     


Gly Ile Thr Gly Val Ile Ile Ala Ile Ile Ala Leu Leu Cys Ile Cys 
            660                 665                 670         


Lys Phe Met Leu 
        675     


<210>  17
<211>  677
<212>  PRT
<213>  Ebola virus

<400>  17

Met Gly Ser Gly Tyr Gln Leu Leu Gln Leu Pro Arg Glu Arg Phe Arg 
1               5                   10                  15      


Lys Thr Ser Phe Leu Val Trp Ala Ile Ile Leu Phe Gln Arg Ala Ile 
            20                  25                  30          


Ser Met Pro Leu Gly Ile Val Thr Asn Ser Thr Leu Lys Ala Thr Glu 
        35                  40                  45              


Ile Asp Gln Leu Val Cys Arg Asp Lys Leu Ser Ser Thr Ser Gln Leu 
    50                  55                  60                  


Lys Ser Val Gly Leu Asn Leu Glu Gly Asn Gly Ile Ala Thr Asp Val 
65                  70                  75                  80  


Pro Ser Ala Thr Lys Arg Trp Gly Phe Arg Ser Gly Val Pro Pro Lys 
                85                  90                  95      


Val Val Ser Tyr Glu Ala Gly Glu Trp Ala Glu Asn Cys Tyr Asn Leu 
            100                 105                 110         


Glu Ile Lys Lys Ser Asp Gly Ser Glu Cys Leu Pro Pro Pro Pro Asp 
        115                 120                 125             


Gly Val Arg Gly Phe Pro Arg Cys Arg Tyr Val His Lys Val Gln Gly 
    130                 135                 140                 


Thr Gly Pro Cys Pro Gly Asp Leu Ala Phe His Lys Asn Gly Ala Phe 
145                 150                 155                 160 


Phe Leu Tyr Asp Arg Leu Ala Ser Thr Val Ile Tyr Arg Gly Thr Thr 
                165                 170                 175     


Phe Ala Glu Gly Val Ile Ala Phe Leu Ile Leu Ser Glu Pro Arg Lys 
            180                 185                 190         


His Phe Trp Lys Ala Thr Pro Ala His Glu Pro Val Asn Thr Thr Asp 
        195                 200                 205             


Asp Ser Thr Ser Tyr Tyr Ile Thr Leu Thr Leu Ser Tyr Glu Met Ser 
    210                 215                 220                 


Asn Phe Gly Gly Glu Glu Ser Asn Thr Leu Phe Lys Val Asp Asn His 
225                 230                 235                 240 


Thr Tyr Val Gln Leu Asp Arg Pro His Thr Pro Gln Phe Leu Val Gln 
                245                 250                 255     


Leu Asn Glu Thr Leu Arg Arg Asn Asn Arg Leu Ser Asn Ser Thr Gly 
            260                 265                 270         


Arg Leu Thr Trp Thr Leu Asp Pro Lys Ile Glu Pro Asn Val Gly Glu 
        275                 280                 285             


Trp Ala Phe Trp Glu Thr Lys Lys Asn Phe Ser Lys Gln Leu Gln Gly 
    290                 295                 300                 


Glu Asn Leu His Phe Gln Ile Leu Ser Thr His Thr Asn Asn Ser Ser 
305                 310                 315                 320 


Asp Gln Ser Pro Ala Gly Thr Val Gln Gly Lys Ile Ser Tyr His Pro 
                325                 330                 335     


Pro Thr Asn Asn Ser Glu Leu Val Pro Thr Asp Ser Pro Pro Val Val 
            340                 345                 350         


Ser Val Leu Thr Ala Gly Arg Thr Glu Glu Met Ser Thr Gln Gly Leu 
        355                 360                 365             


Thr Asn Gly Glu Thr Ile Thr Gly Phe Thr Ala Asn Pro Met Thr Thr 
    370                 375                 380                 


Thr Ile Ala Leu Ser Pro Thr Met Thr Ser Lys Val Asp Asn Asn Val 
385                 390                 395                 400 


Pro Ser Glu Gln Pro Asn Asn Thr Thr Ser Ile Glu Asp Ser Pro Pro 
                405                 410                 415     


Ser Ala Ser Asn Glu Thr Ile Asp His Ser Glu Met Asn Ser Ile Gln 
            420                 425                 430         


Gly Ser Asn Asn Ser Thr Gln Ser Pro Gln Thr Lys Thr Lys Pro Ala 
        435                 440                 445             


Pro Thr Ala Ser Leu Met Thr Leu Gly Pro Gln Glu Thr Ala Asn Ser 
    450                 455                 460                 


Ser Lys Pro Gly Thr Ser Pro Gly Ser Ala Ala Glu Pro Ser Gln Pro 
465                 470                 475                 480 


Gly Leu Thr Ile Asn Thr Val Ser Lys Val Ala Asp Ser Leu Ser Pro 
                485                 490                 495     


Thr Arg Lys Gln Lys Arg Ser Val Arg Gln Asn Thr Ala Asn Glu Cys 
            500                 505                 510         


Asn Pro Asp Leu His Tyr Trp Thr Ala Val Asp Glu Gly Ala Ala Val 
        515                 520                 525             


Gly Leu Ala Trp Ile Pro Tyr Phe Gly Pro Ala Ala Glu Gly Ile Tyr 
    530                 535                 540                 


Ile Glu Gly Val Met His Asn Gln Asn Gly Leu Ile Cys Gly Leu Arg 
545                 550                 555                 560 


Gln Leu Ala Asn Glu Thr Thr Gln Ala Leu Gln Leu Phe Leu Arg Ala 
                565                 570                 575     


Thr Thr Glu Leu Arg Thr Tyr Ser Leu Leu Asn Arg Lys Ala Ile Asp 
            580                 585                 590         


Phe Leu Leu Gln Arg Trp Gly Gly Thr Cys Arg Ile Leu Gly Pro Ser 
        595                 600                 605             


Cys Cys Ile Glu Pro His Asp Trp Thr Lys Asn Ile Thr Asp Glu Ile 
    610                 615                 620                 


Asn Gln Ile Lys His Asp Phe Ile Asp Asn Pro Leu Pro Asp His Gly 
625                 630                 635                 640 


Asp Asp Leu Asn Leu Trp Thr Gly Trp Arg Gln Trp Ile Pro Ala Gly 
                645                 650                 655     


Ile Gly Ile Ile Gly Val Ile Ile Ala Ile Thr Ala Leu Leu Cys Ile 
            660                 665                 670         


Cys Lys Ile Leu Cys 
        675         


<210>  18
<211>  681
<212>  PRT
<213>  Marburg virus

<400>  18

Met Lys Thr Ile Tyr Phe Leu Ile Ser Leu Ile Leu Ile Gln Ser Ile 
1               5                   10                  15      


Lys Thr Leu Pro Val Leu Glu Ile Ala Ser Asn Ser Gln Pro Gln Asp 
            20                  25                  30          


Val Asp Ser Val Cys Ser Gly Thr Leu Gln Lys Thr Glu Asp Val His 
        35                  40                  45              


Leu Met Gly Phe Thr Leu Ser Gly Gln Lys Val Ala Asp Ser Pro Leu 
    50                  55                  60                  


Glu Ala Ser Lys Arg Trp Ala Phe Arg Thr Gly Val Pro Pro Lys Asn 
65                  70                  75                  80  


Val Glu Tyr Thr Glu Gly Glu Glu Ala Lys Thr Cys Tyr Asn Ile Ser 
                85                  90                  95      


Val Thr Asp Pro Ser Gly Lys Ser Leu Leu Leu Asp Pro Pro Ser Asn 
            100                 105                 110         


Ile Arg Asp Tyr Pro Lys Cys Lys Thr Val His His Ile Gln Gly Gln 
        115                 120                 125             


Asn Pro His Ala Gln Gly Ile Ala Leu His Leu Trp Gly Ala Phe Phe 
    130                 135                 140                 


Leu Tyr Asp Arg Val Ala Ser Thr Thr Met Tyr Arg Gly Lys Val Phe 
145                 150                 155                 160 


Thr Glu Gly Asn Ile Ala Ala Met Ile Val Asn Lys Thr Val His Arg 
                165                 170                 175     


Met Ile Phe Ser Arg Gln Gly Gln Gly Tyr Arg His Met Asn Leu Thr 
            180                 185                 190         


Ser Thr Asn Lys Tyr Trp Thr Ser Ser Asn Glu Thr Gln Arg Asn Asp 
        195                 200                 205             


Thr Gly Cys Phe Gly Ile Leu Gln Glu Tyr Asn Ser Thr Asn Asn Gln 
    210                 215                 220                 


Thr Cys Pro Pro Ser Leu Lys Pro Pro Ser Leu Pro Thr Val Thr Pro 
225                 230                 235                 240 


Ser Ile His Ser Thr Asn Thr Gln Ile Asn Thr Ala Lys Ser Gly Thr 
                245                 250                 255     


Met Asn Pro Ser Ser Asp Asp Glu Asp Leu Met Ile Ser Gly Ser Gly 
            260                 265                 270         


Ser Gly Glu Gln Gly Pro His Thr Thr Leu Asn Val Val Thr Glu Gln 
        275                 280                 285             


Lys Gln Ser Ser Thr Ile Leu Ser Thr Pro Ser Leu His Pro Ser Thr 
    290                 295                 300                 


Ser Gln His Glu Gln Asn Ser Thr Asn Pro Ser Arg His Ala Val Thr 
305                 310                 315                 320 


Glu His Asn Gly Thr Asp Pro Thr Thr Gln Pro Ala Thr Leu Leu Asn 
                325                 330                 335     


Asn Thr Asn Thr Thr Pro Thr Tyr Asn Thr Leu Lys Tyr Asn Leu Ser 
            340                 345                 350         


Thr Pro Ser Pro Pro Thr Arg Asn Ile Thr Asn Asn Asp Thr Gln Arg 
        355                 360                 365             


Glu Leu Ala Glu Ser Glu Gln Thr Asn Ala Gln Leu Asn Thr Thr Leu 
    370                 375                 380                 


Asp Pro Thr Glu Asn Pro Thr Thr Gly Gln Asp Thr Asn Ser Thr Thr 
385                 390                 395                 400 


Asn Ile Ile Met Thr Thr Ser Asp Ile Thr Ser Lys His Pro Thr Asn 
                405                 410                 415     


Ser Ser Pro Asp Ser Ser Pro Thr Thr Arg Pro Pro Ile Tyr Phe Arg 
            420                 425                 430         


Lys Lys Arg Ser Ile Phe Trp Lys Glu Gly Asp Ile Phe Pro Phe Leu 
        435                 440                 445             


Asp Gly Leu Ile Asn Thr Glu Ile Asp Phe Asp Pro Ile Pro Asn Thr 
    450                 455                 460                 


Glu Thr Ile Phe Asp Glu Ser Pro Ser Phe Asn Thr Ser Thr Asn Glu 
465                 470                 475                 480 


Glu Gln His Thr Pro Pro Asn Ile Ser Leu Thr Phe Ser Tyr Phe Pro 
                485                 490                 495     


Asp Lys Asn Gly Asp Thr Ala Tyr Ser Gly Glu Asn Glu Asn Asp Cys 
            500                 505                 510         


Asp Ala Glu Leu Arg Ile Trp Ser Val Gln Glu Asp Asp Leu Ala Ala 
        515                 520                 525             


Gly Leu Ser Trp Ile Pro Phe Phe Gly Pro Gly Ile Glu Gly Leu Tyr 
    530                 535                 540                 


Thr Ala Gly Leu Ile Lys Asn Gln Asn Asn Leu Val Cys Arg Leu Arg 
545                 550                 555                 560 


Arg Leu Ala Asn Gln Thr Ala Lys Ser Leu Glu Leu Leu Leu Arg Val 
                565                 570                 575     


Thr Thr Glu Glu Arg Thr Phe Ser Leu Ile Asn Arg His Ala Ile Asp 
            580                 585                 590         


Phe Leu Leu Thr Arg Trp Gly Gly Thr Cys Lys Val Leu Gly Pro Asp 
        595                 600                 605             


Cys Cys Ile Gly Ile Glu Asp Leu Ser Lys Asn Ile Ser Glu Gln Ile 
    610                 615                 620                 


Asp Lys Ile Arg Lys Asp Glu Gln Lys Glu Glu Thr Gly Trp Gly Leu 
625                 630                 635                 640 


Gly Gly Lys Trp Trp Thr Ser Asp Trp Gly Val Leu Thr Asn Leu Gly 
                645                 650                 655     


Ile Leu Leu Leu Leu Ser Ile Ala Val Leu Ile Ala Leu Ser Cys Ile 
            660                 665                 670         


Cys Arg Ile Phe Thr Lys Tyr Ile Gly 
        675                 680     


<210>  19
<211>  681
<212>  PRT
<213>  Marburg virus

<400>  19

Met Lys Thr Thr Cys Leu Leu Ile Ser Leu Ile Leu Ile Gln Gly Val 
1               5                   10                  15      


Lys Thr Leu Pro Ile Leu Glu Ile Ala Ser Asn Ile Gln Pro Gln Asn 
            20                  25                  30          


Val Asp Ser Val Cys Ser Gly Thr Leu Gln Lys Thr Glu Asp Val His 
        35                  40                  45              


Leu Met Gly Phe Thr Leu Ser Gly Gln Lys Val Ala Asp Ser Pro Leu 
    50                  55                  60                  


Glu Ala Ser Lys Arg Trp Ala Phe Arg Ala Gly Val Pro Pro Lys Asn 
65                  70                  75                  80  


Val Glu Tyr Thr Glu Gly Glu Glu Ala Lys Thr Cys Tyr Asn Ile Ser 
                85                  90                  95      


Val Thr Asp Pro Ser Gly Lys Ser Leu Leu Leu Asp Pro Pro Thr Asn 
            100                 105                 110         


Ile Arg Asp Tyr Pro Lys Cys Lys Thr Ile His His Ile Gln Gly Gln 
        115                 120                 125             


Asn Pro His Ala Gln Gly Ile Ala Leu His Leu Trp Gly Ala Phe Phe 
    130                 135                 140                 


Leu Tyr Asp Arg Ile Ala Ser Thr Thr Met Tyr Arg Gly Lys Val Phe 
145                 150                 155                 160 


Thr Glu Gly Asn Ile Ala Ala Met Ile Val Asn Lys Thr Val His Lys 
                165                 170                 175     


Met Ile Phe Ser Arg Gln Gly Gln Gly Tyr Arg His Met Asn Leu Thr 
            180                 185                 190         


Ser Thr Asn Lys Tyr Trp Thr Ser Ser Asn Gly Thr Gln Thr Asn Asp 
        195                 200                 205             


Thr Gly Cys Phe Gly Thr Leu Gln Glu Tyr Asn Ser Thr Lys Asn Gln 
    210                 215                 220                 


Thr Cys Ala Pro Ser Lys Lys Pro Leu Pro Leu Pro Thr Ala His Pro 
225                 230                 235                 240 


Glu Val Lys Leu Thr Ser Thr Ser Thr Asp Ala Thr Lys Leu Asn Thr 
                245                 250                 255     


Thr Asp Pro Asn Ser Asp Asp Glu Asp Leu Thr Thr Ser Gly Ser Gly 
            260                 265                 270         


Ser Gly Glu Gln Glu Pro Tyr Thr Thr Ser Asp Ala Ala Thr Lys Gln 
        275                 280                 285             


Gly Leu Ser Ser Thr Met Pro Pro Thr Pro Ser Pro Gln Pro Ser Thr 
    290                 295                 300                 


Pro Gln Gln Gly Gly Asn Asn Thr Asn His Ser Gln Gly Val Val Thr 
305                 310                 315                 320 


Glu Pro Gly Lys Thr Asn Thr Thr Ala Gln Pro Ser Met Pro Pro His 
                325                 330                 335     


Asn Thr Thr Thr Ile Ser Thr Asn Asn Thr Ser Lys His Asn Leu Ser 
            340                 345                 350         


Thr Pro Ser Val Pro Ile Gln Asn Ala Thr Asn Tyr Asn Thr Gln Ser 
        355                 360                 365             


Thr Ala Pro Glu Asn Glu Gln Thr Ser Ala Pro Ser Lys Thr Thr Leu 
    370                 375                 380                 


Leu Pro Thr Glu Asn Pro Thr Thr Ala Lys Ser Thr Asn Ser Thr Lys 
385                 390                 395                 400 


Ser Pro Thr Thr Thr Val Pro Asn Thr Thr Asn Lys Tyr Ser Thr Ser 
                405                 410                 415     


Pro Ser Pro Thr Pro Asp Ser Thr Ala Gln His Leu Val Tyr Phe Arg 
            420                 425                 430         


Arg Lys Arg Asn Ile Leu Trp Arg Glu Gly Asp Met Phe Pro Phe Leu 
        435                 440                 445             


Asp Gly Leu Ile Asn Ala Pro Ile Asp Phe Asp Pro Val Pro Asn Thr 
    450                 455                 460                 


Lys Thr Ile Phe Asp Glu Ser Ser Ser Ser Gly Ala Ser Ala Glu Glu 
465                 470                 475                 480 


Asp Gln His Ala Ser Pro Asn Ile Ser Leu Thr Leu Ser Tyr Phe Pro 
                485                 490                 495     


Lys Val Asn Glu Asn Thr Ala His Ser Gly Glu Asn Glu Asn Asp Cys 
            500                 505                 510         


Asp Ala Glu Leu Arg Ile Trp Ser Val Gln Glu Asp Asp Leu Ala Ala 
        515                 520                 525             


Gly Leu Ser Trp Ile Pro Phe Phe Gly Pro Gly Ile Glu Gly Leu Tyr 
    530                 535                 540                 


Thr Ala Gly Leu Ile Lys Asn Gln Asn Asn Leu Val Cys Arg Leu Arg 
545                 550                 555                 560 


Arg Leu Ala Asn Gln Thr Ala Lys Ser Leu Glu Leu Leu Leu Arg Val 
                565                 570                 575     


Thr Thr Glu Glu Arg Thr Phe Ser Leu Ile Asn Arg His Ala Ile Asp 
            580                 585                 590         


Phe Leu Leu Ala Arg Trp Gly Gly Thr Cys Lys Val Leu Gly Pro Asp 
        595                 600                 605             


Cys Cys Ile Gly Ile Glu Asp Leu Ser Arg Asn Ile Ser Glu Gln Ile 
    610                 615                 620                 


Asp Gln Ile Lys Lys Asp Glu Gln Lys Glu Gly Thr Gly Trp Gly Leu 
625                 630                 635                 640 


Gly Gly Lys Trp Trp Thr Ser Asp Trp Gly Val Leu Thr Asn Leu Gly 
                645                 650                 655     


Ile Leu Leu Leu Leu Ser Ile Ala Val Leu Ile Ala Leu Ser Cys Ile 
            660                 665                 670         


Cys Arg Ile Phe Thr Lys Tyr Ile Gly 
        675                 680     


<210>  20
<211>  118
<212>  PRT
<213>  rhesus macaque

<400>  20

Glu Val Gln Leu Val Gln Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Met Arg Leu Ser Cys Glu Ala Ser Gly Leu Ser Leu Ser Asp Tyr 
            20                  25                  30          


Phe Met His Trp Val Arg Gln Ala Gln Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Leu Ile Gln Thr Lys Ala Phe Thr Tyr Lys Thr Glu Tyr Pro Ala 
    50                  55                  60                  


Ala Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr 
65                  70                  75                  80  


Leu Tyr Leu Gln Met Ser Ser Leu Lys Pro Glu Asp Thr Ala Leu Tyr 
                85                  90                  95      


Tyr Cys Ile Ala Val Thr Pro Asp Phe Tyr Tyr Trp Gly Gln Gly Val 
            100                 105                 110         


Leu Val Thr Val Ser Ser 
        115             


<210>  21
<211>  110
<212>  PRT
<213>  rhesus macaque

<400>  21

Asp Val Val Met Thr Gln Ser Pro Ser Phe Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Ile Thr Ile Asn 
            20                  25                  30          


Leu Asn Trp Phe Gln His Lys Pro Gly Lys Ala Pro Lys Arg Leu Ile 
        35                  40                  45              


Tyr Val Ala Ser Arg Leu Glu Arg Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Asn Asn Tyr Pro Leu 
                85                  90                  95      


Thr Phe Gly Pro Gly Thr Lys Leu Asp Ile Lys Arg Thr Val 
            100                 105                 110 


<210>  22
<211>  10
<212>  PRT
<213>  rhesus macaque

<400>  22

Gly Leu Ser Leu Ser Asp Tyr Phe Met His 
1               5                   10  


<210>  23
<211>  10
<212>  PRT
<213>  rhesus macaque

<400>  23

Ile Gln Thr Lys Ala Phe Thr Tyr Lys Thr 
1               5                   10  


<210>  24
<211>  9
<212>  PRT
<213>  rhesus macaque

<400>  24

Ile Ala Val Thr Pro Asp Phe Tyr Tyr 
1               5                   


<210>  25
<211>  6
<212>  PRT
<213>  rhesus macaque

<400>  25

Gln Asp Ile Thr Ile Asn 
1               5       


<210>  26
<211>  3
<212>  PRT
<213>  rhesus macaque

<400>  26

Val Ala Ser 
1           


<210>  27
<211>  9
<212>  PRT
<213>  rhesus macaque

<400>  27

Gln Gln Tyr Asn Asn Tyr Pro Leu Thr 
1               5                   


<210>  28
<211>  119
<212>  PRT
<213>  cynomolgus macaque

<400>  28

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Ala Val Ser Gly Gly Ser Ile Ser Gly Gly 
            20                  25                  30          


Tyr Tyr Tyr Trp Ser Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu 
        35                  40                  45              


Trp Ile Gly Asn Ile Tyr Asn Ser Ala Ser Thr Tyr Tyr Asn Pro Ser 
    50                  55                  60                  


Leu Lys Ser Arg Val Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Phe 
65                  70                  75                  80  


Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr 
                85                  90                  95      


Cys Ala Arg Gly Val Val Ile Thr Gly Leu Asp Ser Trp Gly Gln Gly 
            100                 105                 110         


Val Val Val Thr Val Ser Ser 
        115                 


<210>  29
<211>  106
<212>  PRT
<213>  cynomolgus macaque

<400>  29

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Ser Ser Tyr 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Asp Ala Ser Asn Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln His Asn Ser Tyr Pro Leu 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Val Glu Ile 
            100                 105     


<210>  30
<211>  7
<212>  PRT
<213>  Ebola virus

<400>  30

Gln Leu Arg Ser Val Gly Leu 
1               5           


<210>  31
<211>  7
<212>  PRT
<213>  Ebola virus

<400>  31

Pro Asn Leu His Tyr Trp Thr 
1               5           


<210>  32
<211>  8
<212>  PRT
<213>  Ebola virus

<400>  32

Tyr Thr Glu Gly Leu Met His Asn 
1               5               


<210>  33
<211>  7
<212>  PRT
<213>  Marburg virus

<400>  33

Asp Val His Leu Met Gly Phe 
1               5           


<210>  34
<211>  7
<212>  PRT
<213>  Marburg virus

<400>  34

Ala Glu Leu Arg Ile Trp Ser 
1               5           


<210>  35
<211>  8
<212>  PRT
<213>  Marburg virus

<400>  35

Tyr Thr Ala Gly Leu Ile Lys Asn 
1               5               


