                         SEQUENCE LISTING

<110>  TSAI, Kun-Chih
       YANG, Patrick Yuhmin
 
<120>  A novel invadopodia-specific marker of invasive cancer stem cells
        and the use thereof

<130>  docket number

<150>  US62/405,998
<151>  2016-10-10

<160>  2     

<170>  PatentIn version 3.5

<210>  1
<211>  1305
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (1)..(1305)
<223>  This sequence encodes the human phosphopyruvate hydratase protein

<400>  1
atg tct att ctc aag atc cat gcc agg gag atc ttt gac tct cgc ggg         48
Met Ser Ile Leu Lys Ile His Ala Arg Glu Ile Phe Asp Ser Arg Gly           
1               5                   10                  15                

aat ccc act gtt gag gtt gat ctc ttc acc tca aaa ggt ctc ttc aga         96
Asn Pro Thr Val Glu Val Asp Leu Phe Thr Ser Lys Gly Leu Phe Arg           
            20                  25                  30                    

gct gct gtg ccc agt ggt gct tca act ggt atc tat gag gcc cta gag        144
Ala Ala Val Pro Ser Gly Ala Ser Thr Gly Ile Tyr Glu Ala Leu Glu           
        35                  40                  45                        

ctc cgg gac aat gat aag act cgc tat atg ggg aag ggt gtc tca aag        192
Leu Arg Asp Asn Asp Lys Thr Arg Tyr Met Gly Lys Gly Val Ser Lys           
    50                  55                  60                            

gct gtt gag cac atc aat aaa act att gcg cct gcc ctg gtt agc aag        240
Ala Val Glu His Ile Asn Lys Thr Ile Ala Pro Ala Leu Val Ser Lys           
65                  70                  75                  80            

aaa ctg aac gtc aca gaa caa gag aag att gac aaa ctg atg atc gag        288
Lys Leu Asn Val Thr Glu Gln Glu Lys Ile Asp Lys Leu Met Ile Glu           
                85                  90                  95                

atg gat gga aca gaa aat aaa tct aag ttt ggt gcg aac gcc att ctg        336
Met Asp Gly Thr Glu Asn Lys Ser Lys Phe Gly Ala Asn Ala Ile Leu           
            100                 105                 110                   

ggg gtg tcc ctt gcc gtc tgc aaa gct ggt gcc gtt gag aag ggg gtc        384
Gly Val Ser Leu Ala Val Cys Lys Ala Gly Ala Val Glu Lys Gly Val           
        115                 120                 125                       

ccc ctg tac cgc cac atc gct gac ttg gct ggc aac tct gaa gtc atc        432
Pro Leu Tyr Arg His Ile Ala Asp Leu Ala Gly Asn Ser Glu Val Ile           
    130                 135                 140                           

ctg cca gtc ccg gcg ttc aat gtc atc aat ggc ggt tct cat gct ggc        480
Leu Pro Val Pro Ala Phe Asn Val Ile Asn Gly Gly Ser His Ala Gly           
145                 150                 155                 160           

aac aag ctg gcc atg cag gag ttc atg atc ctc cca gtc ggt gca gca        528
Asn Lys Leu Ala Met Gln Glu Phe Met Ile Leu Pro Val Gly Ala Ala           
                165                 170                 175               

aac ttc agg gaa gcc atg cgc att gga gca gag gtt tac cac aac ctg        576
Asn Phe Arg Glu Ala Met Arg Ile Gly Ala Glu Val Tyr His Asn Leu           
            180                 185                 190                   

aag aat gtc atc aag gag aaa tat ggg aaa gat gcc acc aat gtg ggg        624
Lys Asn Val Ile Lys Glu Lys Tyr Gly Lys Asp Ala Thr Asn Val Gly           
        195                 200                 205                       

gat gaa ggc ggg ttt gct ccc aac atc ctg gag aat aaa gaa ggc ctg        672
Asp Glu Gly Gly Phe Ala Pro Asn Ile Leu Glu Asn Lys Glu Gly Leu           
    210                 215                 220                           

gag ctg ctg aag act gct att ggg aaa gct ggc tac act gat aag gtg        720
Glu Leu Leu Lys Thr Ala Ile Gly Lys Ala Gly Tyr Thr Asp Lys Val           
225                 230                 235                 240           

gtc atc ggc atg gac gta gcg gcc tcc gag ttc ttc agg tct ggg aag        768
Val Ile Gly Met Asp Val Ala Ala Ser Glu Phe Phe Arg Ser Gly Lys           
                245                 250                 255               

tat gac ctg gac ttc aag tct ccc gat gac ccc agc agg tac atc tcg        816
Tyr Asp Leu Asp Phe Lys Ser Pro Asp Asp Pro Ser Arg Tyr Ile Ser           
            260                 265                 270                   

cct gac cag ctg gct gac ctg tac aag tcc ttc atc aag gac tac cca        864
Pro Asp Gln Leu Ala Asp Leu Tyr Lys Ser Phe Ile Lys Asp Tyr Pro           
        275                 280                 285                       

gtg gtg tct atc gaa gat ccc ttt gac cag gat gac tgg gga gct tgg        912
Val Val Ser Ile Glu Asp Pro Phe Asp Gln Asp Asp Trp Gly Ala Trp           
    290                 295                 300                           

cag aag ttc aca gcc agt gca gga atc cag gta gtg ggg gat gat ctc        960
Gln Lys Phe Thr Ala Ser Ala Gly Ile Gln Val Val Gly Asp Asp Leu           
305                 310                 315                 320           

aca gtg acc aac cca aag agg atc gcc aag gcc gtg aac gag aag tcc       1008
Thr Val Thr Asn Pro Lys Arg Ile Ala Lys Ala Val Asn Glu Lys Ser           
                325                 330                 335               

tgc aac tgc ctc ctg ctc aaa gtc aac cag att ggc tcc gtg acc gag       1056
Cys Asn Cys Leu Leu Leu Lys Val Asn Gln Ile Gly Ser Val Thr Glu           
            340                 345                 350                   

tct ctt cag gcg tgc aag ctg gcc cag gcc aat ggt tgg ggc gtc atg       1104
Ser Leu Gln Ala Cys Lys Leu Ala Gln Ala Asn Gly Trp Gly Val Met           
        355                 360                 365                       

gtg tct cat cgt tcg ggg gag act gaa gat acc ttc atc gct gac ctg       1152
Val Ser His Arg Ser Gly Glu Thr Glu Asp Thr Phe Ile Ala Asp Leu           
    370                 375                 380                           

gtt gtg ggg ctg tgc act ggg cag atc aag act ggt gcc cct tgc cga       1200
Val Val Gly Leu Cys Thr Gly Gln Ile Lys Thr Gly Ala Pro Cys Arg           
385                 390                 395                 400           

tct gag cgc ttg gcc aag tac aac cag ctc ctc aga att gaa gag gag       1248
Ser Glu Arg Leu Ala Lys Tyr Asn Gln Leu Leu Arg Ile Glu Glu Glu           
                405                 410                 415               

ctg ggc agc aag gct aag ttt gcc ggc agg aac ttc aga aac ccc ttg       1296
Leu Gly Ser Lys Ala Lys Phe Ala Gly Arg Asn Phe Arg Asn Pro Leu           
            420                 425                 430                   

gcc aag taa                                                           1305
Ala Lys                                                                   
                                                                          


<210>  2
<211>  434
<212>  PRT
<213>  Homo sapiens

<400>  2

Met Ser Ile Leu Lys Ile His Ala Arg Glu Ile Phe Asp Ser Arg Gly 
1               5                   10                  15      


Asn Pro Thr Val Glu Val Asp Leu Phe Thr Ser Lys Gly Leu Phe Arg 
            20                  25                  30          


Ala Ala Val Pro Ser Gly Ala Ser Thr Gly Ile Tyr Glu Ala Leu Glu 
        35                  40                  45              


Leu Arg Asp Asn Asp Lys Thr Arg Tyr Met Gly Lys Gly Val Ser Lys 
    50                  55                  60                  


Ala Val Glu His Ile Asn Lys Thr Ile Ala Pro Ala Leu Val Ser Lys 
65                  70                  75                  80  


Lys Leu Asn Val Thr Glu Gln Glu Lys Ile Asp Lys Leu Met Ile Glu 
                85                  90                  95      


Met Asp Gly Thr Glu Asn Lys Ser Lys Phe Gly Ala Asn Ala Ile Leu 
            100                 105                 110         


Gly Val Ser Leu Ala Val Cys Lys Ala Gly Ala Val Glu Lys Gly Val 
        115                 120                 125             


Pro Leu Tyr Arg His Ile Ala Asp Leu Ala Gly Asn Ser Glu Val Ile 
    130                 135                 140                 


Leu Pro Val Pro Ala Phe Asn Val Ile Asn Gly Gly Ser His Ala Gly 
145                 150                 155                 160 


Asn Lys Leu Ala Met Gln Glu Phe Met Ile Leu Pro Val Gly Ala Ala 
                165                 170                 175     


Asn Phe Arg Glu Ala Met Arg Ile Gly Ala Glu Val Tyr His Asn Leu 
            180                 185                 190         


Lys Asn Val Ile Lys Glu Lys Tyr Gly Lys Asp Ala Thr Asn Val Gly 
        195                 200                 205             


Asp Glu Gly Gly Phe Ala Pro Asn Ile Leu Glu Asn Lys Glu Gly Leu 
    210                 215                 220                 


Glu Leu Leu Lys Thr Ala Ile Gly Lys Ala Gly Tyr Thr Asp Lys Val 
225                 230                 235                 240 


Val Ile Gly Met Asp Val Ala Ala Ser Glu Phe Phe Arg Ser Gly Lys 
                245                 250                 255     


Tyr Asp Leu Asp Phe Lys Ser Pro Asp Asp Pro Ser Arg Tyr Ile Ser 
            260                 265                 270         


Pro Asp Gln Leu Ala Asp Leu Tyr Lys Ser Phe Ile Lys Asp Tyr Pro 
        275                 280                 285             


Val Val Ser Ile Glu Asp Pro Phe Asp Gln Asp Asp Trp Gly Ala Trp 
    290                 295                 300                 


Gln Lys Phe Thr Ala Ser Ala Gly Ile Gln Val Val Gly Asp Asp Leu 
305                 310                 315                 320 


Thr Val Thr Asn Pro Lys Arg Ile Ala Lys Ala Val Asn Glu Lys Ser 
                325                 330                 335     


Cys Asn Cys Leu Leu Leu Lys Val Asn Gln Ile Gly Ser Val Thr Glu 
            340                 345                 350         


Ser Leu Gln Ala Cys Lys Leu Ala Gln Ala Asn Gly Trp Gly Val Met 
        355                 360                 365             


Val Ser His Arg Ser Gly Glu Thr Glu Asp Thr Phe Ile Ala Asp Leu 
    370                 375                 380                 


Val Val Gly Leu Cys Thr Gly Gln Ile Lys Thr Gly Ala Pro Cys Arg 
385                 390                 395                 400 


Ser Glu Arg Leu Ala Lys Tyr Asn Gln Leu Leu Arg Ile Glu Glu Glu 
                405                 410                 415     


Leu Gly Ser Lys Ala Lys Phe Ala Gly Arg Asn Phe Arg Asn Pro Leu 
            420                 425                 430         


Ala Lys 
        


