               SEQUENCE LISTING

<110> Linnane Pharm AB

<120> Novel Therapy

<130> P3094/WO

<150> GB1617470.8
<151> 2016-10-14

<160> 4

<170> BiSSAP 1.3.6

<210> 1
<211> 3384
<212> DNA
<213> Escherichia coli


<220> 
<223> Genomic sequence

<400> 1
atcagcatgg cagtcagtct gcgggcataa tttttatcgt gtgttttatg gatggctttc       60

tgcatcaggt gtcgttcgtc acgggaaatt ggtgctatga tcggcattgc tcagttcggt      120

tggtgatttg ttttgatttg gcgattgatc agagcgcaca attcgggctg agtaccctca      180

aagtgatcta ctattccgcg cagctattta gcgcattaca ctgctaaatg actaacgcat      240

ccctgtcaat actgctctcg ctgtatgctt acgctgcaga agccatgaca cattttctta      300

cctatcatcg gcacccataa agcaacagtg ttatactata acaattttga tgggggatac      360

tgtggtcagt ctttatgctt tttccgcaat agcccgactg ggtatcgtcg gtgtgctgct      420

ggtactgtta tggactctta tttcttgggc ggtggtactg gcatgatcgc attacattca      480

ctggcatttg gttattcggg acagcacccg ctgggtacgc tggatggatg ttttgacacc      540

ggttcactga ctgccattat cggagcgaat ggcacaggta agtccacctt gcttaaaacg      600

ttggccggtc tgctgccacc cctggggggt tgcttctgta tggtaccgca ggggcaacgc      660

cagttaggtt atttgcccca attgactgaa tttgatcgcc agtttccact gagtgttaac      720

gatctggtgc tgatgggatg tattccacac agcgggatgt tcggtcgtat ttcctgtcta      780

tggcgaaaaa aagctatcga agcgctggat accgtcggta tgacagaatt ttcgcagatg      840

cacatcggca cactttccgg tggtcagtta cagcgcgtac tgttcgcacg actgctggtg      900

atgcagccgt cggttattct gctggatgaa ccatttactg gcattgatgt tcagactatc      960

cgtactctgc tggttgttat tcggcagcta catctggaag gacgtacaat tcttgcggtg     1020

ttgcatgaca tggaacaggt agaaaaatac ttttctcatg tactgatgct cagtgcggaa     1080

ggccaccgat gggggagaag tgccgatata ctccattccc tcacggctgc agtcacgcca     1140

ccgcagcagg ggctgctgcc atgatgttac tgcacctgtt gtgtgagcca tttggcgatt     1200

tcggttttat gcgtcgggca ctggtcggat gtctggcgct gaccctgagt gccgcgccac     1260

ttggctgttt tttgctactg cgccgtatga gcctgatcgg tgatgcactg tcccatgcgg     1320

tgttgccggg agtagcaatt ggctacctgg tatcgggcat gtcgctggtt gcgatgggag     1380

tcggtggctt cattgccggg ctgtctgtgg cgatgttgtc tggtgtggtc agccgccgca     1440

ctggattgag agaagacgcc agtttcgctg ggttttacct cggctcgctg gcacttggcg     1500

tcaccctggt ctctttgcgt ggctccagtg tcgacctgct gcatgtgctg ttcggttcca     1560

ttctggctat tgacgccaat gctctgatca ctatcggcat aattagttcc ggttcagttc     1620

tggtactggc gttgatctac cgggtgctgg tgattgagtc gtttgatgtc actttcctga     1680

aagttctgtc acgtcggtcg cgggcgctga tccactgcct gtttttgtca atggtggtac     1740

tcaatctggt ggctggtttc cagctacttg gcaccctgat gacagtcggt attatgatgt     1800

taccggctgc cagcgcgcgt ttctggagtc aacgtctgtc catcatgttg ttagcggcag     1860

tgggtattgg tacctgcgcc agtctggttg gactgacctg gtcttattac gctgatttgc     1920

ctgcaggccc tgcggtcatc ctcacgagca ctctgttttt ctgcttttca gttctgtttg     1980

gctctaatgg cggcatgtta tgcagatgtc gctgacaaga agtgttttta cacatagcaa     2040

cgagatgaag gaggaaagat gaaacggtcc attttggttg tggcactgtc cagcctacta     2100

gtaagcccac tggtgattgc aaaagagttg aatgtggtgg caagtttctc ggtactgggc     2160

gatatggtca gccagattgg cggcccatac gttcatgtca ctgatctggt gcaaccggat     2220

ggtgatccac atgaatttga accgtcgccg aaagacagca aaacgctggc acaggcggat     2280

gttgtctttg tcaatggatt gggactggag ggatggctgg accgtctgat gaaagcctct     2340

ggctacagag gtgaggtaat taccgcgtct aacggaatag atacactgaa aatgaaagag     2400

gatgggacca ccatcactga tccgcacgcc tggaacagca tgaaaaacgg tattgtctat     2460

gctcacaaca ttgtcaatgg cctgagcaaa gcagacccgg agcacgccag cgattatcga     2520

aaacagggtg acagctatat ccagcagttg cagcaactgg ataattacgc cacgcagacg     2580

tttgctgcca ttccaagaga aaaacgtaaa gtactgacca gtcatgatgc gtttgggtat     2640

ttcgctgccg cctacggggt tcgctttctg tcgccagtgg ggtactccac tgagtcggaa     2700

gctagcagta aaaatgtggc gaaactgatt aatcaaatta agagagagca cgtaaaattg     2760

tactttatcg aaaaccagac cgatccccgt ttggtgaaac aaatcgccaa tgccagtggt     2820

gcacaagcgg gaggagagct ttatccggaa gcacttaccg acagtagcgg cctcgctgct     2880

acctacacgg cagcgttcaa acacaatgtc gataccctcg ctgctggcat gaagtaagag     2940

agttggcaaa aaagtaagta gatatcaggt tgccccatat catcaggtaa cctgtgacac     3000

ttctcttgcc agagcgccat gttccagcgc ctcactcact atctgcttat catccgactt     3060

tccctcatac ctgtctcgat tataaagata aaacgatgat gcccgggttc attgtgcgaa     3120

ggcatggcat atttgttccc ggtgtcgtca gacagcatca ttcgactctc catctgctgt     3180

ctgaccagac aaaagatggc cttgtttgcc gcggtggaaa tggagtgccg tctgttcttt     3240

atttattgtt tatgttatgt tatagcatat aaaagagtat tgtttggcat ctgtaactta     3300

ttgagaaggc aaactgcaga gtggttaatg cagtaattgt attagctaaa attttgttaa     3360

tcaaaatttg tttgattgtt aatg                                            3384


<210> 2
<211> 244
<212> PRT
<213> Escherichia coli


<220> 
<223> ABC transporter protein

<400> 2
Met Asp Ser Tyr Phe Leu Gly Gly Gly Thr Gly Met Ile Ala Leu His 
1               5                   10                  15      
Ser Leu Ala Phe Gly Tyr Ser Gly Gln His Pro Leu Gly Thr Leu Asp 
            20                  25                  30          
Gly Cys Phe Asp Thr Gly Ser Leu Thr Ala Ile Ile Gly Ala Asn Gly 
        35                  40                  45              
Thr Gly Lys Ser Thr Leu Leu Lys Thr Leu Ala Gly Leu Leu Pro Pro 
    50                  55                  60                  
Leu Gly Gly Cys Phe Cys Met Val Pro Gln Gly Gln Arg Gln Leu Gly 
65                  70                  75                  80  
Tyr Leu Pro Gln Leu Thr Glu Phe Asp Arg Gln Phe Pro Leu Ser Val 
                85                  90                  95      
Asn Asp Leu Val Leu Met Gly Cys Ile Pro His Ser Gly Met Phe Gly 
            100                 105                 110         
Arg Ile Ser Cys Leu Trp Arg Lys Lys Ala Ile Glu Ala Leu Asp Thr 
        115                 120                 125             
Val Gly Met Thr Glu Phe Ser Gln Met His Ile Gly Thr Leu Ser Gly 
    130                 135                 140                 
Gly Gln Leu Gln Arg Val Leu Phe Ala Arg Leu Leu Val Met Gln Pro 
145                 150                 155                 160 
Ser Val Ile Leu Leu Asp Glu Pro Phe Thr Gly Ile Asp Val Gln Thr 
                165                 170                 175     
Ile Arg Thr Leu Leu Val Val Ile Arg Gln Leu His Leu Glu Gly Arg 
            180                 185                 190         
Thr Ile Leu Ala Val Leu His Asp Met Glu Gln Val Glu Lys Tyr Phe 
        195                 200                 205             
Ser His Val Leu Met Leu Ser Ala Glu Gly His Arg Trp Gly Arg Ser 
    210                 215                 220                 
Ala Asp Ile Leu His Ser Leu Thr Ala Ala Val Thr Pro Pro Gln Gln 
225                 230                 235                 240 
Gly Leu Leu Pro 
                

<210> 3
<211> 308
<212> PRT
<213> Escherichia coli


<220> 
<223> ABC transporter protein

<400> 3
Met Gly Glu Lys Cys Arg Tyr Thr Pro Phe Pro His Gly Cys Ser His 
1               5                   10                  15      
Ala Thr Ala Ala Gly Ala Ala Ala Met Met Leu Leu His Leu Leu Cys 
            20                  25                  30          
Glu Pro Phe Gly Asp Phe Gly Phe Met Arg Arg Ala Leu Val Gly Cys 
        35                  40                  45              
Leu Ala Leu Thr Leu Ser Ala Ala Pro Leu Gly Cys Phe Leu Leu Leu 
    50                  55                  60                  
Arg Arg Met Ser Leu Ile Gly Asp Ala Leu Ser His Ala Val Leu Pro 
65                  70                  75                  80  
Gly Val Ala Ile Gly Tyr Leu Val Ser Gly Met Ser Leu Val Ala Met 
                85                  90                  95      
Gly Val Gly Gly Phe Ile Ala Gly Leu Ser Val Ala Met Leu Ser Gly 
            100                 105                 110         
Val Val Ser Arg Arg Thr Gly Leu Arg Glu Asp Ala Ser Phe Ala Gly 
        115                 120                 125             
Phe Tyr Leu Gly Ser Leu Ala Leu Gly Val Thr Leu Val Ser Leu Arg 
    130                 135                 140                 
Gly Ser Ser Val Asp Leu Leu His Val Leu Phe Gly Ser Ile Leu Ala 
145                 150                 155                 160 
Ile Asp Ala Asn Ala Leu Ile Thr Ile Gly Ile Ile Ser Ser Gly Ser 
                165                 170                 175     
Val Leu Val Leu Ala Leu Ile Tyr Arg Val Leu Val Ile Glu Ser Phe 
            180                 185                 190         
Asp Val Thr Phe Leu Lys Val Leu Ser Arg Arg Ser Arg Ala Leu Ile 
        195                 200                 205             
His Cys Leu Phe Leu Ser Met Val Val Leu Asn Leu Val Ala Gly Phe 
    210                 215                 220                 
Gln Leu Leu Gly Thr Leu Met Thr Val Gly Ile Met Met Leu Pro Ala 
225                 230                 235                 240 
Ala Ser Ala Arg Phe Trp Ser Gln Arg Leu Ser Ile Met Leu Leu Ala 
                245                 250                 255     
Ala Val Gly Ile Gly Thr Cys Ala Ser Leu Val Gly Leu Thr Trp Ser 
            260                 265                 270         
Tyr Tyr Ala Asp Leu Pro Ala Gly Pro Ala Val Ile Leu Thr Ser Thr 
        275                 280                 285             
Leu Phe Phe Cys Phe Ser Val Leu Phe Gly Ser Asn Gly Gly Met Leu 
    290                 295                 300                 
Cys Arg Cys Arg 
305             

<210> 4
<211> 292
<212> PRT
<213> Escherichia coli


<220> 
<223> ABC transporter protein

<400> 4
Met Lys Arg Ser Ile Leu Val Val Ala Leu Ser Ser Leu Leu Val Ser 
1               5                   10                  15      
Pro Leu Val Ile Ala Lys Glu Leu Asn Val Val Ala Ser Phe Ser Val 
            20                  25                  30          
Leu Gly Asp Met Val Ser Gln Ile Gly Gly Pro Tyr Val His Val Thr 
        35                  40                  45              
Asp Leu Val Gln Pro Asp Gly Asp Pro His Glu Phe Glu Pro Ser Pro 
    50                  55                  60                  
Lys Asp Ser Lys Thr Leu Ala Gln Ala Asp Val Val Phe Val Asn Gly 
65                  70                  75                  80  
Leu Gly Leu Glu Gly Trp Leu Asp Arg Leu Met Lys Ala Ser Gly Tyr 
                85                  90                  95      
Arg Gly Glu Val Ile Thr Ala Ser Asn Gly Ile Asp Thr Leu Lys Met 
            100                 105                 110         
Lys Glu Asp Gly Thr Thr Ile Thr Asp Pro His Ala Trp Asn Ser Met 
        115                 120                 125             
Lys Asn Gly Ile Val Tyr Ala His Asn Ile Val Asn Gly Leu Ser Lys 
    130                 135                 140                 
Ala Asp Pro Glu His Ala Ser Asp Tyr Arg Lys Gln Gly Asp Ser Tyr 
145                 150                 155                 160 
Ile Gln Gln Leu Gln Gln Leu Asp Asn Tyr Ala Thr Gln Thr Phe Ala 
                165                 170                 175     
Ala Ile Pro Arg Glu Lys Arg Lys Val Leu Thr Ser His Asp Ala Phe 
            180                 185                 190         
Gly Tyr Phe Ala Ala Ala Tyr Gly Val Arg Phe Leu Ser Pro Val Gly 
        195                 200                 205             
Tyr Ser Thr Glu Ser Glu Ala Ser Ser Lys Asn Val Ala Lys Leu Ile 
    210                 215                 220                 
Asn Gln Ile Lys Arg Glu His Val Lys Leu Tyr Phe Ile Glu Asn Gln 
225                 230                 235                 240 
Thr Asp Pro Arg Leu Val Lys Gln Ile Ala Asn Ala Ser Gly Ala Gln 
                245                 250                 255     
Ala Gly Gly Glu Leu Tyr Pro Glu Ala Leu Thr Asp Ser Ser Gly Leu 
            260                 265                 270         
Ala Ala Thr Tyr Thr Ala Ala Phe Lys His Asn Val Asp Thr Leu Ala 
        275                 280                 285             
Ala Gly Met Lys 
    290         

