                         SEQUENCE LISTING

<110>  Kemijski Institut, Hajdrihova 19, 1000 Ljubljana, Slovenia
       EN-FIST center odlicnosti, Trg Osvobodilne fronte 13, 1000 Ljubljana, Slovenia
 
<120>  A method for increasing the sensitivity of cells to ultrasound 
       and mechanical stimuli, which includes gas bubbles and cells 
       with increased susceptibility of mechanosensors

<130>  0301-P27PC/17

<150>  P-201600251
<151>  10.10.2016
       

<160>  18    

<170>  PatentIn version 3.5

<210>  1
<211>  237
<212>  DNA
<213>  Anabaena flos-aquae


<220>
<221>  CDS
<222>  (1)..(18)
<223>  HA

<220>
<221>  CDS
<222>  (19)..(234)
<223>  GvpA

<400>  1
atg gac aca tac agg tat atc gcc gtg gag aag gtg aac agc agc agc         48
Met Asp Thr Tyr Arg Tyr Ile Ala Val Glu Lys Val Asn Ser Ser Ser           
1               5                   10                  15                

agc ctg gcc gag gtg atc gac aga atc ctg gac aag ggc atc gtg atc         96
Ser Leu Ala Glu Val Ile Asp Arg Ile Leu Asp Lys Gly Ile Val Ile           
            20                  25                  30                    

gac gcc tgg gtg aga gtg agc ctg gtg ggc atc gag ctg ctg agc atc        144
Asp Ala Trp Val Arg Val Ser Leu Val Gly Ile Glu Leu Leu Ser Ile           
        35                  40                  45                        

gag gcc aga atc gtg atc gcc agc gtg gag acc tac ctg aag tac gcc        192
Glu Ala Arg Ile Val Ile Ala Ser Val Glu Thr Tyr Leu Lys Tyr Ala           
    50                  55                  60                            

gag gcc gtg ggc ctg acc gcc cag gcc gcc gtg ccc agc gtg taa            237
Glu Ala Val Gly Leu Thr Ala Gln Ala Ala Val Pro Ser Val                   
65                  70                  75                                


<210>  2
<211>  78
<212>  PRT
<213>  Anabaena flos-aquae

<400>  2

Met Asp Thr Tyr Arg Tyr Ile Ala Val Glu Lys Val Asn Ser Ser Ser 
1               5                   10                  15      


Ser Leu Ala Glu Val Ile Asp Arg Ile Leu Asp Lys Gly Ile Val Ile 
            20                  25                  30          


Asp Ala Trp Val Arg Val Ser Leu Val Gly Ile Glu Leu Leu Ser Ile 
        35                  40                  45              


Glu Ala Arg Ile Val Ile Ala Ser Val Glu Thr Tyr Leu Lys Tyr Ala 
    50                  55                  60                  


Glu Ala Val Gly Leu Thr Ala Gln Ala Ala Val Pro Ser Val 
65                  70                  75              


<210>  3
<211>  567
<212>  DNA
<213>  Anabaena flos-aquae


<220>
<221>  CDS
<222>  (1)..(66)
<223>  3FLAG

<220>
<221>  CDS
<222>  (67)..(564)
<223>  GvpC

<400>  3
atg gac tat aag gat cat gac ggc gac tac aaa gac cac gat gac tac         48
Met Asp Tyr Lys Asp His Asp Gly Asp Tyr Lys Asp His Asp Asp Tyr           
1               5                   10                  15                

aag gat gac gat gac aag gct tta aaa gac aag tgg caa cag gat cgt         96
Lys Asp Asp Asp Asp Lys Ala Leu Lys Asp Lys Trp Gln Gln Asp Arg           
            20                  25                  30                    

atc gga cgc caa cag gga gtt caa gaa cgg caa cag caa gtt caa acc        144
Ile Gly Arg Gln Gln Gly Val Gln Glu Arg Gln Gln Gln Val Gln Thr           
        35                  40                  45                        

acc cta tcc ctc tgg caa caa gag cgc caa aat cag gct tct gaa ttt        192
Thr Leu Ser Leu Trp Gln Gln Glu Arg Gln Asn Gln Ala Ser Glu Phe           
    50                  55                  60                            

cgg gaa gac cta gaa tat cgg gta acg gat ctg tta gct aat tat cag        240
Arg Glu Asp Leu Glu Tyr Arg Val Thr Asp Leu Leu Ala Asn Tyr Gln           
65                  70                  75                  80            

aaa cag cgc cta gaa gct agg gaa act tta ctt gag gac tta gct att        288
Lys Gln Arg Leu Glu Ala Arg Glu Thr Leu Leu Glu Asp Leu Ala Ile           
                85                  90                  95                

ttt cgt caa acc cta tat cgg gaa gtc gaa gaa tat tta ggg gag tta        336
Phe Arg Gln Thr Leu Tyr Arg Glu Val Glu Glu Tyr Leu Gly Glu Leu           
            100                 105                 110                   

gat att ctg cac cag caa atg gcc gca caa tta caa caa caa ctc caa        384
Asp Ile Leu His Gln Gln Met Ala Ala Gln Leu Gln Gln Gln Leu Gln           
        115                 120                 125                       

cag agt cgg acg gaa aga aaa gac gct gtt cag aag tta ttc gag gat        432
Gln Ser Arg Thr Glu Arg Lys Asp Ala Val Gln Lys Leu Phe Glu Asp           
    130                 135                 140                           

tta ggg gta ttt cgc gcc gaa cta caa gac tat cac ctc aaa ctt caa        480
Leu Gly Val Phe Arg Ala Glu Leu Gln Asp Tyr His Leu Lys Leu Gln           
145                 150                 155                 160           

cag aca gtt tgg ggg agt tcc cac cga aaa ccg cga aaa gcg att acc        528
Gln Thr Val Trp Gly Ser Ser His Arg Lys Pro Arg Lys Ala Ile Thr           
                165                 170                 175               

ccg caa cgc tct att cca tcg cgt tta tat tcc tgt taa                    567
Pro Gln Arg Ser Ile Pro Ser Arg Leu Tyr Ser Cys                           
            180                 185                                       


<210>  4
<211>  188
<212>  PRT
<213>  Anabaena flos-aquae

<400>  4

Met Asp Tyr Lys Asp His Asp Gly Asp Tyr Lys Asp His Asp Asp Tyr 
1               5                   10                  15      


Lys Asp Asp Asp Asp Lys Ala Leu Lys Asp Lys Trp Gln Gln Asp Arg 
            20                  25                  30          


Ile Gly Arg Gln Gln Gly Val Gln Glu Arg Gln Gln Gln Val Gln Thr 
        35                  40                  45              


Thr Leu Ser Leu Trp Gln Gln Glu Arg Gln Asn Gln Ala Ser Glu Phe 
    50                  55                  60                  


Arg Glu Asp Leu Glu Tyr Arg Val Thr Asp Leu Leu Ala Asn Tyr Gln 
65                  70                  75                  80  


Lys Gln Arg Leu Glu Ala Arg Glu Thr Leu Leu Glu Asp Leu Ala Ile 
                85                  90                  95      


Phe Arg Gln Thr Leu Tyr Arg Glu Val Glu Glu Tyr Leu Gly Glu Leu 
            100                 105                 110         


Asp Ile Leu His Gln Gln Met Ala Ala Gln Leu Gln Gln Gln Leu Gln 
        115                 120                 125             


Gln Ser Arg Thr Glu Arg Lys Asp Ala Val Gln Lys Leu Phe Glu Asp 
    130                 135                 140                 


Leu Gly Val Phe Arg Ala Glu Leu Gln Asp Tyr His Leu Lys Leu Gln 
145                 150                 155                 160 


Gln Thr Val Trp Gly Ser Ser His Arg Lys Pro Arg Lys Ala Ile Thr 
                165                 170                 175     


Pro Gln Arg Ser Ile Pro Ser Arg Leu Tyr Ser Cys 
            180                 185             


<210>  5
<211>  888
<212>  DNA
<213>  Escherichia coli


<220>
<221>  CDS
<222>  (1)..(858)
<223>  MscS

<220>
<221>  CDS
<222>  (859)..(885)
<223>  HA

<400>  5
atg gaa gat ttg aat gtt gtc gat agc ata aac ggc gcg gga agc tgg         48
Met Glu Asp Leu Asn Val Val Asp Ser Ile Asn Gly Ala Gly Ser Trp           
1               5                   10                  15                

ctg gta gct aac cag gcg ctg ctg cta agt tat gca gta aac atc gtg         96
Leu Val Ala Asn Gln Ala Leu Leu Leu Ser Tyr Ala Val Asn Ile Val           
            20                  25                  30                    

gcg gca ctc gcg atc atc atc gtt ggt ttg att atc gcg cgg atg att        144
Ala Ala Leu Ala Ile Ile Ile Val Gly Leu Ile Ile Ala Arg Met Ile           
        35                  40                  45                        

tcc aac gcg gtg aat cgc ctg atg atc tcc cgt aaa atc gat gcc act        192
Ser Asn Ala Val Asn Arg Leu Met Ile Ser Arg Lys Ile Asp Ala Thr           
    50                  55                  60                            

gtt gct gat ttt ctt tct gca tta gtc cgt tac ggt att atc gcc ttt        240
Val Ala Asp Phe Leu Ser Ala Leu Val Arg Tyr Gly Ile Ile Ala Phe           
65                  70                  75                  80            

acg cta atc gct gca ctg gga cgc gtg ggt gta caa acc gcg tca gtc        288
Thr Leu Ile Ala Ala Leu Gly Arg Val Gly Val Gln Thr Ala Ser Val           
                85                  90                  95                

att gct gta ctc ggt gcc gca ggc tta gct gtt ggt ctg gct ttg cag        336
Ile Ala Val Leu Gly Ala Ala Gly Leu Ala Val Gly Leu Ala Leu Gln           
            100                 105                 110                   

ggg tca ctg tct aac ctg gcc gct ggc gtg tta ctt gtc atg ttc cgc        384
Gly Ser Leu Ser Asn Leu Ala Ala Gly Val Leu Leu Val Met Phe Arg           
        115                 120                 125                       

ccg ttc cgt gcc gga gaa tat gtt gac ctg ggc ggc gta gcc ggt act        432
Pro Phe Arg Ala Gly Glu Tyr Val Asp Leu Gly Gly Val Ala Gly Thr           
    130                 135                 140                           

gtg ctg agt gtg cag att ttc tcc acc acc atg cgt act gca gac ggt        480
Val Leu Ser Val Gln Ile Phe Ser Thr Thr Met Arg Thr Ala Asp Gly           
145                 150                 155                 160           

aaa att atc gtt att ccg aac ggt aaa att att gcc gga aat att att        528
Lys Ile Ile Val Ile Pro Asn Gly Lys Ile Ile Ala Gly Asn Ile Ile           
                165                 170                 175               

aac ttc tcc cgc gag cca gtt cgc cgt aac gaa ttt att att ggc gtg        576
Asn Phe Ser Arg Glu Pro Val Arg Arg Asn Glu Phe Ile Ile Gly Val           
            180                 185                 190                   

gcg tat gat tcc gat atc gat cag gtt aag cag atc ctg acc aat att        624
Ala Tyr Asp Ser Asp Ile Asp Gln Val Lys Gln Ile Leu Thr Asn Ile           
        195                 200                 205                       

atc cag tct gaa gat cgc att ttg aaa gat cgc gaa atg act gtg cgc        672
Ile Gln Ser Glu Asp Arg Ile Leu Lys Asp Arg Glu Met Thr Val Arg           
    210                 215                 220                           

ctg aac gaa ctt ggt gca tcg tcg att aat ttc gtg gtc cgc gtc tgg        720
Leu Asn Glu Leu Gly Ala Ser Ser Ile Asn Phe Val Val Arg Val Trp           
225                 230                 235                 240           

agc aac agc ggc gat ctg caa aac gtg tac tgg gat gtg ctg gag cgt        768
Ser Asn Ser Gly Asp Leu Gln Asn Val Tyr Trp Asp Val Leu Glu Arg           
                245                 250                 255               

att aaa cgt gaa ttt gat gcc gcc ggt atc agc ttc ccg tac ccg caa        816
Ile Lys Arg Glu Phe Asp Ala Ala Gly Ile Ser Phe Pro Tyr Pro Gln           
            260                 265                 270                   

atg gat gtg aac ttt aag cgg gtg aaa gaa gac aaa gct gcg tac cca        864
Met Asp Val Asn Phe Lys Arg Val Lys Glu Asp Lys Ala Ala Tyr Pro           
        275                 280                 285                       

tac gat gtt cca gat tac gct taa                                        888
Tyr Asp Val Pro Asp Tyr Ala                                               
    290                 295                                               


<210>  6
<211>  295
<212>  PRT
<213>  Escherichia coli

<400>  6

Met Glu Asp Leu Asn Val Val Asp Ser Ile Asn Gly Ala Gly Ser Trp 
1               5                   10                  15      


Leu Val Ala Asn Gln Ala Leu Leu Leu Ser Tyr Ala Val Asn Ile Val 
            20                  25                  30          


Ala Ala Leu Ala Ile Ile Ile Val Gly Leu Ile Ile Ala Arg Met Ile 
        35                  40                  45              


Ser Asn Ala Val Asn Arg Leu Met Ile Ser Arg Lys Ile Asp Ala Thr 
    50                  55                  60                  


Val Ala Asp Phe Leu Ser Ala Leu Val Arg Tyr Gly Ile Ile Ala Phe 
65                  70                  75                  80  


Thr Leu Ile Ala Ala Leu Gly Arg Val Gly Val Gln Thr Ala Ser Val 
                85                  90                  95      


Ile Ala Val Leu Gly Ala Ala Gly Leu Ala Val Gly Leu Ala Leu Gln 
            100                 105                 110         


Gly Ser Leu Ser Asn Leu Ala Ala Gly Val Leu Leu Val Met Phe Arg 
        115                 120                 125             


Pro Phe Arg Ala Gly Glu Tyr Val Asp Leu Gly Gly Val Ala Gly Thr 
    130                 135                 140                 


Val Leu Ser Val Gln Ile Phe Ser Thr Thr Met Arg Thr Ala Asp Gly 
145                 150                 155                 160 


Lys Ile Ile Val Ile Pro Asn Gly Lys Ile Ile Ala Gly Asn Ile Ile 
                165                 170                 175     


Asn Phe Ser Arg Glu Pro Val Arg Arg Asn Glu Phe Ile Ile Gly Val 
            180                 185                 190         


Ala Tyr Asp Ser Asp Ile Asp Gln Val Lys Gln Ile Leu Thr Asn Ile 
        195                 200                 205             


Ile Gln Ser Glu Asp Arg Ile Leu Lys Asp Arg Glu Met Thr Val Arg 
    210                 215                 220                 


Leu Asn Glu Leu Gly Ala Ser Ser Ile Asn Phe Val Val Arg Val Trp 
225                 230                 235                 240 


Ser Asn Ser Gly Asp Leu Gln Asn Val Tyr Trp Asp Val Leu Glu Arg 
                245                 250                 255     


Ile Lys Arg Glu Phe Asp Ala Ala Gly Ile Ser Phe Pro Tyr Pro Gln 
            260                 265                 270         


Met Asp Val Asn Phe Lys Arg Val Lys Glu Asp Lys Ala Ala Tyr Pro 
        275                 280                 285             


Tyr Asp Val Pro Asp Tyr Ala 
    290                 295 


<210>  7
<211>  2310
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (1)..(2277)
<223>  TrpC1

<220>
<221>  CDS
<222>  (2278)..(2307)
<223>  Myc

<400>  7
atg atg gcg gcc ctg tac ccg agc acg gac ctc tcg ggc gcc tcc tcc         48
Met Met Ala Ala Leu Tyr Pro Ser Thr Asp Leu Ser Gly Ala Ser Ser           
1               5                   10                  15                

tcc tcc ctg cct tcc tct cca tcc tct tcc tcg ccg aac gag gtg atg         96
Ser Ser Leu Pro Ser Ser Pro Ser Ser Ser Ser Pro Asn Glu Val Met           
            20                  25                  30                    

gcg ctg aag gat gtg cgg gag gtg aag gag gag aat acg ctg aat gag        144
Ala Leu Lys Asp Val Arg Glu Val Lys Glu Glu Asn Thr Leu Asn Glu           
        35                  40                  45                        

aag ctt ttc ttg ctg gcg tgc gac aag ggt gac tat tat atg gtt aaa        192
Lys Leu Phe Leu Leu Ala Cys Asp Lys Gly Asp Tyr Tyr Met Val Lys           
    50                  55                  60                            

aag att ttg gag gaa aac agt tca ggt gac ttg aac ata aat tgc gta        240
Lys Ile Leu Glu Glu Asn Ser Ser Gly Asp Leu Asn Ile Asn Cys Val           
65                  70                  75                  80            

gat gtg ctt ggg aga aat gct gtt acc ata act att gaa aac gaa aac        288
Asp Val Leu Gly Arg Asn Ala Val Thr Ile Thr Ile Glu Asn Glu Asn           
                85                  90                  95                

ttg gat ata ctg cag ctt ctt ttg gac tac ggt tgt cag aaa cta atg        336
Leu Asp Ile Leu Gln Leu Leu Leu Asp Tyr Gly Cys Gln Lys Leu Met           
            100                 105                 110                   

gaa cga att cag aat cct gag tat tca aca act atg gat gtt gca cct        384
Glu Arg Ile Gln Asn Pro Glu Tyr Ser Thr Thr Met Asp Val Ala Pro           
        115                 120                 125                       

gtc att tta gct gct cat cgt aac aac tat gaa att ctt aca atg ctc        432
Val Ile Leu Ala Ala His Arg Asn Asn Tyr Glu Ile Leu Thr Met Leu           
    130                 135                 140                           

tta aaa cag gat gta tct cta ccc aag ccc cat gca gtt ggc tgt gaa        480
Leu Lys Gln Asp Val Ser Leu Pro Lys Pro His Ala Val Gly Cys Glu           
145                 150                 155                 160           

tgc aca ttg tgt tct gca aaa aac aaa aag gat agc ctc cgg cat tcc        528
Cys Thr Leu Cys Ser Ala Lys Asn Lys Lys Asp Ser Leu Arg His Ser           
                165                 170                 175               

agg ttt cgt ctt gat ata tat cga tgt ttg gcc agt cca gct cta ata        576
Arg Phe Arg Leu Asp Ile Tyr Arg Cys Leu Ala Ser Pro Ala Leu Ile           
            180                 185                 190                   

atg tta aca gag gag gat cca att ctg aga gca ttt gaa ctt agt gct        624
Met Leu Thr Glu Glu Asp Pro Ile Leu Arg Ala Phe Glu Leu Ser Ala           
        195                 200                 205                       

gat tta aaa gaa cta agt ctt gtg gag gtg gaa ttc agg aat gat tat        672
Asp Leu Lys Glu Leu Ser Leu Val Glu Val Glu Phe Arg Asn Asp Tyr           
    210                 215                 220                           

gag gaa cta gcc cgg caa tgt aaa atg ttt gct aag gat tta ctt gca        720
Glu Glu Leu Ala Arg Gln Cys Lys Met Phe Ala Lys Asp Leu Leu Ala           
225                 230                 235                 240           

caa gcc cgg aat tct cgt gaa ttg gaa gtt att cta aac cat acg tct        768
Gln Ala Arg Asn Ser Arg Glu Leu Glu Val Ile Leu Asn His Thr Ser           
                245                 250                 255               

agt gac gag cct ctt gac aaa cgg gga tta tta gaa gaa aga atg aat        816
Ser Asp Glu Pro Leu Asp Lys Arg Gly Leu Leu Glu Glu Arg Met Asn           
            260                 265                 270                   

tta agt cgt cta aaa ctt gct atc aaa tat aac cag aaa gag ttt gtc        864
Leu Ser Arg Leu Lys Leu Ala Ile Lys Tyr Asn Gln Lys Glu Phe Val           
        275                 280                 285                       

tcc cag tct aac tgc cag cag ttc ctg aac act gtt tgg ttt gga cag        912
Ser Gln Ser Asn Cys Gln Gln Phe Leu Asn Thr Val Trp Phe Gly Gln           
    290                 295                 300                           

atg tcg ggt tac cga cgc aag ccc acc tgt aag aag ata atg act gtt        960
Met Ser Gly Tyr Arg Arg Lys Pro Thr Cys Lys Lys Ile Met Thr Val           
305                 310                 315                 320           

ttg aca gta ggc atc ttt tgg cca gtt ttg tca ctt tgt tat ttg ata       1008
Leu Thr Val Gly Ile Phe Trp Pro Val Leu Ser Leu Cys Tyr Leu Ile           
                325                 330                 335               

gct ccc aaa tct cag ttt ggc aga atc att cac aca cct ttt atg aaa       1056
Ala Pro Lys Ser Gln Phe Gly Arg Ile Ile His Thr Pro Phe Met Lys           
            340                 345                 350                   

ttt atc att cat gga gca tca tat ttc aca ttt ctg ctg ttg ctt aat       1104
Phe Ile Ile His Gly Ala Ser Tyr Phe Thr Phe Leu Leu Leu Leu Asn           
        355                 360                 365                       

cta tac tct ctt gtc tac aat gag gat aag aaa aac aca atg ggg cca       1152
Leu Tyr Ser Leu Val Tyr Asn Glu Asp Lys Lys Asn Thr Met Gly Pro           
    370                 375                 380                           

gcc ctt gaa aga ata gac tat ctt ctt att ctg tgg att att ggg atg       1200
Ala Leu Glu Arg Ile Asp Tyr Leu Leu Ile Leu Trp Ile Ile Gly Met           
385                 390                 395                 400           

att tgg tca gac att aaa aga ctc tgg tat gaa ggg ttg gaa gac ttt       1248
Ile Trp Ser Asp Ile Lys Arg Leu Trp Tyr Glu Gly Leu Glu Asp Phe           
                405                 410                 415               

tta gaa gaa tct cgt aat caa ctc agt ttt gtc atg aat tct ctt tat       1296
Leu Glu Glu Ser Arg Asn Gln Leu Ser Phe Val Met Asn Ser Leu Tyr           
            420                 425                 430                   

ttg gca acc ttt gcc ctc aaa gtg gtt gct cac aac aag ttt cat gat       1344
Leu Ala Thr Phe Ala Leu Lys Val Val Ala His Asn Lys Phe His Asp           
        435                 440                 445                       

ttt gct gat cgg aag gat tgg gat gca ttc cat cct aca ctg gtg gca       1392
Phe Ala Asp Arg Lys Asp Trp Asp Ala Phe His Pro Thr Leu Val Ala           
    450                 455                 460                           

gaa ggg ctt ttt gca ttt gca aat gtt cta agt tat ctt cgt ctc ttt       1440
Glu Gly Leu Phe Ala Phe Ala Asn Val Leu Ser Tyr Leu Arg Leu Phe           
465                 470                 475                 480           

ttt atg tat aca acc agc tct atc ttg ggt cca tta cag att tca atg       1488
Phe Met Tyr Thr Thr Ser Ser Ile Leu Gly Pro Leu Gln Ile Ser Met           
                485                 490                 495               

gga cag atg tta caa gat ttt gga aaa ttt ctt ggg atg ttt ctt ctt       1536
Gly Gln Met Leu Gln Asp Phe Gly Lys Phe Leu Gly Met Phe Leu Leu           
            500                 505                 510                   

gtt ttg ttt tct ttc aca att gga ctg aca caa ctg tat gat aaa gga       1584
Val Leu Phe Ser Phe Thr Ile Gly Leu Thr Gln Leu Tyr Asp Lys Gly           
        515                 520                 525                       

tat act tca aag gag cag aag gac tgt gta ggc atc ttc tgt gaa cag       1632
Tyr Thr Ser Lys Glu Gln Lys Asp Cys Val Gly Ile Phe Cys Glu Gln           
    530                 535                 540                           

caa agc aat gat acc ttc cat tcg ttc att ggc acc tgc ttt gct ttg       1680
Gln Ser Asn Asp Thr Phe His Ser Phe Ile Gly Thr Cys Phe Ala Leu           
545                 550                 555                 560           

ttc tgg tat att ttc tcc tta gcg cat gtg gca atc ttt gtc aca aga       1728
Phe Trp Tyr Ile Phe Ser Leu Ala His Val Ala Ile Phe Val Thr Arg           
                565                 570                 575               

ttt agc tat gga gaa gaa ctg cag tcc ttt gtg gga gct gtc att gtt       1776
Phe Ser Tyr Gly Glu Glu Leu Gln Ser Phe Val Gly Ala Val Ile Val           
            580                 585                 590                   

ggt aca tac aat gtc gtg gtt gtg att gtg ctt acc aaa ctg ctg gtg       1824
Gly Thr Tyr Asn Val Val Val Val Ile Val Leu Thr Lys Leu Leu Val           
        595                 600                 605                       

gca atg ctt cat aaa agc ttt cag ttg ata gca aat cat gaa gac aaa       1872
Ala Met Leu His Lys Ser Phe Gln Leu Ile Ala Asn His Glu Asp Lys           
    610                 615                 620                           

gaa tgg aag ttt gct cga gca aaa tta tgg ctt agc tac ttt gat gac       1920
Glu Trp Lys Phe Ala Arg Ala Lys Leu Trp Leu Ser Tyr Phe Asp Asp           
625                 630                 635                 640           

aaa tgt acg tta cct cca cct ttc aac atc att ccc tca cca aag act       1968
Lys Cys Thr Leu Pro Pro Pro Phe Asn Ile Ile Pro Ser Pro Lys Thr           
                645                 650                 655               

atc tgc tat atg att agt agc ctc agt aag tgg att tgc tct cat aca       2016
Ile Cys Tyr Met Ile Ser Ser Leu Ser Lys Trp Ile Cys Ser His Thr           
            660                 665                 670                   

tca aaa ggc aag gtc aaa cgg caa aac agt tta aag gaa tgg agg aat       2064
Ser Lys Gly Lys Val Lys Arg Gln Asn Ser Leu Lys Glu Trp Arg Asn           
        675                 680                 685                       

ttg aaa cag aag aga gat gaa aac tat caa aaa gtg atg tgc tgc cta       2112
Leu Lys Gln Lys Arg Asp Glu Asn Tyr Gln Lys Val Met Cys Cys Leu           
    690                 695                 700                           

gtg cat cgt tac ttg act tcc atg aga cag aag atg caa agt aca gat       2160
Val His Arg Tyr Leu Thr Ser Met Arg Gln Lys Met Gln Ser Thr Asp           
705                 710                 715                 720           

cag gca act gtg gaa aat cta aac gaa ctg cgc caa gat ctg tca aaa       2208
Gln Ala Thr Val Glu Asn Leu Asn Glu Leu Arg Gln Asp Leu Ser Lys           
                725                 730                 735               

ttc cga aat gaa ata agg gat tta ctt ggc ttt cgg act tct aaa tat       2256
Phe Arg Asn Glu Ile Arg Asp Leu Leu Gly Phe Arg Thr Ser Lys Tyr           
            740                 745                 750                   

gct atg ttt tat cca aga aat gag cag aag ctg atc agc gag gag gac       2304
Ala Met Phe Tyr Pro Arg Asn Glu Gln Lys Leu Ile Ser Glu Glu Asp           
        755                 760                 765                       

ctg taa                                                               2310
Leu                                                                       
                                                                          


<210>  8
<211>  769
<212>  PRT
<213>  Homo sapiens

<400>  8

Met Met Ala Ala Leu Tyr Pro Ser Thr Asp Leu Ser Gly Ala Ser Ser 
1               5                   10                  15      


Ser Ser Leu Pro Ser Ser Pro Ser Ser Ser Ser Pro Asn Glu Val Met 
            20                  25                  30          


Ala Leu Lys Asp Val Arg Glu Val Lys Glu Glu Asn Thr Leu Asn Glu 
        35                  40                  45              


Lys Leu Phe Leu Leu Ala Cys Asp Lys Gly Asp Tyr Tyr Met Val Lys 
    50                  55                  60                  


Lys Ile Leu Glu Glu Asn Ser Ser Gly Asp Leu Asn Ile Asn Cys Val 
65                  70                  75                  80  


Asp Val Leu Gly Arg Asn Ala Val Thr Ile Thr Ile Glu Asn Glu Asn 
                85                  90                  95      


Leu Asp Ile Leu Gln Leu Leu Leu Asp Tyr Gly Cys Gln Lys Leu Met 
            100                 105                 110         


Glu Arg Ile Gln Asn Pro Glu Tyr Ser Thr Thr Met Asp Val Ala Pro 
        115                 120                 125             


Val Ile Leu Ala Ala His Arg Asn Asn Tyr Glu Ile Leu Thr Met Leu 
    130                 135                 140                 


Leu Lys Gln Asp Val Ser Leu Pro Lys Pro His Ala Val Gly Cys Glu 
145                 150                 155                 160 


Cys Thr Leu Cys Ser Ala Lys Asn Lys Lys Asp Ser Leu Arg His Ser 
                165                 170                 175     


Arg Phe Arg Leu Asp Ile Tyr Arg Cys Leu Ala Ser Pro Ala Leu Ile 
            180                 185                 190         


Met Leu Thr Glu Glu Asp Pro Ile Leu Arg Ala Phe Glu Leu Ser Ala 
        195                 200                 205             


Asp Leu Lys Glu Leu Ser Leu Val Glu Val Glu Phe Arg Asn Asp Tyr 
    210                 215                 220                 


Glu Glu Leu Ala Arg Gln Cys Lys Met Phe Ala Lys Asp Leu Leu Ala 
225                 230                 235                 240 


Gln Ala Arg Asn Ser Arg Glu Leu Glu Val Ile Leu Asn His Thr Ser 
                245                 250                 255     


Ser Asp Glu Pro Leu Asp Lys Arg Gly Leu Leu Glu Glu Arg Met Asn 
            260                 265                 270         


Leu Ser Arg Leu Lys Leu Ala Ile Lys Tyr Asn Gln Lys Glu Phe Val 
        275                 280                 285             


Ser Gln Ser Asn Cys Gln Gln Phe Leu Asn Thr Val Trp Phe Gly Gln 
    290                 295                 300                 


Met Ser Gly Tyr Arg Arg Lys Pro Thr Cys Lys Lys Ile Met Thr Val 
305                 310                 315                 320 


Leu Thr Val Gly Ile Phe Trp Pro Val Leu Ser Leu Cys Tyr Leu Ile 
                325                 330                 335     


Ala Pro Lys Ser Gln Phe Gly Arg Ile Ile His Thr Pro Phe Met Lys 
            340                 345                 350         


Phe Ile Ile His Gly Ala Ser Tyr Phe Thr Phe Leu Leu Leu Leu Asn 
        355                 360                 365             


Leu Tyr Ser Leu Val Tyr Asn Glu Asp Lys Lys Asn Thr Met Gly Pro 
    370                 375                 380                 


Ala Leu Glu Arg Ile Asp Tyr Leu Leu Ile Leu Trp Ile Ile Gly Met 
385                 390                 395                 400 


Ile Trp Ser Asp Ile Lys Arg Leu Trp Tyr Glu Gly Leu Glu Asp Phe 
                405                 410                 415     


Leu Glu Glu Ser Arg Asn Gln Leu Ser Phe Val Met Asn Ser Leu Tyr 
            420                 425                 430         


Leu Ala Thr Phe Ala Leu Lys Val Val Ala His Asn Lys Phe His Asp 
        435                 440                 445             


Phe Ala Asp Arg Lys Asp Trp Asp Ala Phe His Pro Thr Leu Val Ala 
    450                 455                 460                 


Glu Gly Leu Phe Ala Phe Ala Asn Val Leu Ser Tyr Leu Arg Leu Phe 
465                 470                 475                 480 


Phe Met Tyr Thr Thr Ser Ser Ile Leu Gly Pro Leu Gln Ile Ser Met 
                485                 490                 495     


Gly Gln Met Leu Gln Asp Phe Gly Lys Phe Leu Gly Met Phe Leu Leu 
            500                 505                 510         


Val Leu Phe Ser Phe Thr Ile Gly Leu Thr Gln Leu Tyr Asp Lys Gly 
        515                 520                 525             


Tyr Thr Ser Lys Glu Gln Lys Asp Cys Val Gly Ile Phe Cys Glu Gln 
    530                 535                 540                 


Gln Ser Asn Asp Thr Phe His Ser Phe Ile Gly Thr Cys Phe Ala Leu 
545                 550                 555                 560 


Phe Trp Tyr Ile Phe Ser Leu Ala His Val Ala Ile Phe Val Thr Arg 
                565                 570                 575     


Phe Ser Tyr Gly Glu Glu Leu Gln Ser Phe Val Gly Ala Val Ile Val 
            580                 585                 590         


Gly Thr Tyr Asn Val Val Val Val Ile Val Leu Thr Lys Leu Leu Val 
        595                 600                 605             


Ala Met Leu His Lys Ser Phe Gln Leu Ile Ala Asn His Glu Asp Lys 
    610                 615                 620                 


Glu Trp Lys Phe Ala Arg Ala Lys Leu Trp Leu Ser Tyr Phe Asp Asp 
625                 630                 635                 640 


Lys Cys Thr Leu Pro Pro Pro Phe Asn Ile Ile Pro Ser Pro Lys Thr 
                645                 650                 655     


Ile Cys Tyr Met Ile Ser Ser Leu Ser Lys Trp Ile Cys Ser His Thr 
            660                 665                 670         


Ser Lys Gly Lys Val Lys Arg Gln Asn Ser Leu Lys Glu Trp Arg Asn 
        675                 680                 685             


Leu Lys Gln Lys Arg Asp Glu Asn Tyr Gln Lys Val Met Cys Cys Leu 
    690                 695                 700                 


Val His Arg Tyr Leu Thr Ser Met Arg Gln Lys Met Gln Ser Thr Asp 
705                 710                 715                 720 


Gln Ala Thr Val Glu Asn Leu Asn Glu Leu Arg Gln Asp Leu Ser Lys 
                725                 730                 735     


Phe Arg Asn Glu Ile Arg Asp Leu Leu Gly Phe Arg Thr Ser Lys Tyr 
            740                 745                 750         


Ala Met Phe Tyr Pro Arg Asn Glu Gln Lys Leu Ile Ser Glu Glu Asp 
        755                 760                 765             


Leu 
    


<210>  9
<211>  3240
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  -


<220>
<221>  CDS
<222>  (1)..(111)
<223>  HA

<220>
<221>  CDS
<222>  (112)..(807)
<223>  Fas

<220>
<221>  CDS
<222>  (808)..(816)

<220>
<221>  CDS
<222>  (817)..(843)
<223>  HA

<220>
<221>  CDS
<222>  (844)..(933)
<223>  GS30

<220>
<221>  CDS
<222>  (934)..(3207)
<223>  TrpC1

<220>
<221>  CDS
<222>  (3208)..(3237)
<223>  Myc

<400>  9
atg tcc ccg gaa gat gag atc cag caa ctg gaa gaa gaa atc gct cag         48
Met Ser Pro Glu Asp Glu Ile Gln Gln Leu Glu Glu Glu Ile Ala Gln           
1               5                   10                  15                

ctg gaa cag aaa aac gca gcg ctg aaa gag aaa aac cag gcg ctg aaa         96
Leu Glu Gln Lys Asn Ala Ala Leu Lys Glu Lys Asn Gln Ala Leu Lys           
            20                  25                  30                    

tac ggt ggc tct ggc ctg ggc atc tgg acc ctc cta cct ctg gtt ctt        144
Tyr Gly Gly Ser Gly Leu Gly Ile Trp Thr Leu Leu Pro Leu Val Leu           
        35                  40                  45                        

acg tct gtt gct aga tta tcg tcc aaa agt gtt aat gcc tac ccc tac        192
Thr Ser Val Ala Arg Leu Ser Ser Lys Ser Val Asn Ala Tyr Pro Tyr           
    50                  55                  60                            

gac gtg ccc gac tac gcc caa gtg act gac atc aac tcc aag gga ttg        240
Asp Val Pro Asp Tyr Ala Gln Val Thr Asp Ile Asn Ser Lys Gly Leu           
65                  70                  75                  80            

gaa ttg agg aag act gtt act aca gtt gag act cag aac ttg gaa ggc        288
Glu Leu Arg Lys Thr Val Thr Thr Val Glu Thr Gln Asn Leu Glu Gly           
                85                  90                  95                

ctg cat cat gat ggc caa ttc tgc cat aag ccc tgt cct cca ggt gaa        336
Leu His His Asp Gly Gln Phe Cys His Lys Pro Cys Pro Pro Gly Glu           
            100                 105                 110                   

agg aaa gct agg gac tgc aca gtc aat ggg gat gaa cca gac tgc gtg        384
Arg Lys Ala Arg Asp Cys Thr Val Asn Gly Asp Glu Pro Asp Cys Val           
        115                 120                 125                       

ccc tgc caa gaa ggg aag gag tac aca gac aaa gcc cat ttt tct tcc        432
Pro Cys Gln Glu Gly Lys Glu Tyr Thr Asp Lys Ala His Phe Ser Ser           
    130                 135                 140                           

aaa tgc aga aga tgt aga ttg tgt gat gaa gga cat ggc tta gaa gtg        480
Lys Cys Arg Arg Cys Arg Leu Cys Asp Glu Gly His Gly Leu Glu Val           
145                 150                 155                 160           

gaa ata aac tgc acc cgg acc cag aat acc aag tgc aga tgt aaa cca        528
Glu Ile Asn Cys Thr Arg Thr Gln Asn Thr Lys Cys Arg Cys Lys Pro           
                165                 170                 175               

aac ttt ttt tgt aac tct act gta tgt gaa cac tgt gac cct tgc acc        576
Asn Phe Phe Cys Asn Ser Thr Val Cys Glu His Cys Asp Pro Cys Thr           
            180                 185                 190                   

aaa tgt gaa cat gga atc atc aag gaa tgc aca ctc acc agc aac acc        624
Lys Cys Glu His Gly Ile Ile Lys Glu Cys Thr Leu Thr Ser Asn Thr           
        195                 200                 205                       

aag tgc aaa gag gaa gga tcc aga tct aac ttg ggg tgg ctt tgt ctt        672
Lys Cys Lys Glu Glu Gly Ser Arg Ser Asn Leu Gly Trp Leu Cys Leu           
    210                 215                 220                           

ctt ctt ttg cca att cca cta att gtt tgg gtg aag aga aag gaa gta        720
Leu Leu Leu Pro Ile Pro Leu Ile Val Trp Val Lys Arg Lys Glu Val           
225                 230                 235                 240           

cag aaa aca tgc aga aag cac aga aag gaa aac caa ggt tct cat gaa        768
Gln Lys Thr Cys Arg Lys His Arg Lys Glu Asn Gln Gly Ser His Glu           
                245                 250                 255               

tct cca acc tta aat cct gaa aca gtg gca ata aat tta ggc tct ggc        816
Ser Pro Thr Leu Asn Pro Glu Thr Val Ala Ile Asn Leu Gly Ser Gly           
            260                 265                 270                   

tac cca tac gat gtt cca gat tac gct ggc ggc tct gga ggc ggc tcc        864
Tyr Pro Tyr Asp Val Pro Asp Tyr Ala Gly Gly Ser Gly Gly Gly Ser           
        275                 280                 285                       

gga ggg tct ggc gga tcc ggc ggc ggc tct gga ggc tct ggc ggc tct        912
Gly Gly Ser Gly Gly Ser Gly Gly Gly Ser Gly Gly Ser Gly Gly Ser           
    290                 295                 300                           

gga ggc ggg tcc gga ggc tcc atg gcg gcc ctg tac ccg agc acg gac        960
Gly Gly Gly Ser Gly Gly Ser Met Ala Ala Leu Tyr Pro Ser Thr Asp           
305                 310                 315                 320           

ctc tcg ggc gcc tcc tcc tcc tcc ctg cct tcc tct cca tcc tct tcc       1008
Leu Ser Gly Ala Ser Ser Ser Ser Leu Pro Ser Ser Pro Ser Ser Ser           
                325                 330                 335               

tcg ccg aac gag gtg atg gcg ctg aag gat gtg cgg gag gtg aag gag       1056
Ser Pro Asn Glu Val Met Ala Leu Lys Asp Val Arg Glu Val Lys Glu           
            340                 345                 350                   

gag aat acg ctg aat gag aag ctt ttc ttg ctg gcg tgc gac aag ggt       1104
Glu Asn Thr Leu Asn Glu Lys Leu Phe Leu Leu Ala Cys Asp Lys Gly           
        355                 360                 365                       

gac tat tat atg gtt aaa aag att ttg gag gaa aac agt tca ggt gac       1152
Asp Tyr Tyr Met Val Lys Lys Ile Leu Glu Glu Asn Ser Ser Gly Asp           
    370                 375                 380                           

ttg aac ata aat tgc gta gat gtg ctt ggg aga aat gct gtt acc ata       1200
Leu Asn Ile Asn Cys Val Asp Val Leu Gly Arg Asn Ala Val Thr Ile           
385                 390                 395                 400           

act att gaa aac gaa aac ttg gat ata ctg cag ctt ctt ttg gac tac       1248
Thr Ile Glu Asn Glu Asn Leu Asp Ile Leu Gln Leu Leu Leu Asp Tyr           
                405                 410                 415               

ggt tgt cag aaa cta atg gaa cga att cag aat cct gag tat tca aca       1296
Gly Cys Gln Lys Leu Met Glu Arg Ile Gln Asn Pro Glu Tyr Ser Thr           
            420                 425                 430                   

act atg gat gtt gca cct gtc att tta gct gct cat cgt aac aac tat       1344
Thr Met Asp Val Ala Pro Val Ile Leu Ala Ala His Arg Asn Asn Tyr           
        435                 440                 445                       

gaa att ctt aca atg ctc tta aaa cag gat gta tct cta ccc aag ccc       1392
Glu Ile Leu Thr Met Leu Leu Lys Gln Asp Val Ser Leu Pro Lys Pro           
    450                 455                 460                           

cat gca gtt ggc tgt gaa tgc aca ttg tgt tct gca aaa aac aaa aag       1440
His Ala Val Gly Cys Glu Cys Thr Leu Cys Ser Ala Lys Asn Lys Lys           
465                 470                 475                 480           

gat agc ctc cgg cat tcc agg ttt cgt ctt gat ata tat cga tgt ttg       1488
Asp Ser Leu Arg His Ser Arg Phe Arg Leu Asp Ile Tyr Arg Cys Leu           
                485                 490                 495               

gcc agt cca gct cta ata atg tta aca gag gag gat cca att ctg aga       1536
Ala Ser Pro Ala Leu Ile Met Leu Thr Glu Glu Asp Pro Ile Leu Arg           
            500                 505                 510                   

gca ttt gaa ctt agt gct gat tta aaa gaa cta agt ctt gtg gag gtg       1584
Ala Phe Glu Leu Ser Ala Asp Leu Lys Glu Leu Ser Leu Val Glu Val           
        515                 520                 525                       

gaa ttc agg aat gat tat gag gaa cta gcc cgg caa tgt aaa atg ttt       1632
Glu Phe Arg Asn Asp Tyr Glu Glu Leu Ala Arg Gln Cys Lys Met Phe           
    530                 535                 540                           

gct aag gat tta ctt gca caa gcc cgg aat tct cgt gaa ttg gaa gtt       1680
Ala Lys Asp Leu Leu Ala Gln Ala Arg Asn Ser Arg Glu Leu Glu Val           
545                 550                 555                 560           

att cta aac cat acg tct agt gac gag cct ctt gac aaa cgg gga tta       1728
Ile Leu Asn His Thr Ser Ser Asp Glu Pro Leu Asp Lys Arg Gly Leu           
                565                 570                 575               

tta gaa gaa aga atg aat tta agt cgt cta aaa ctt gct atc aaa tat       1776
Leu Glu Glu Arg Met Asn Leu Ser Arg Leu Lys Leu Ala Ile Lys Tyr           
            580                 585                 590                   

aac cag aaa gag ttt gtc tcc cag tct aac tgc cag cag ttc ctg aac       1824
Asn Gln Lys Glu Phe Val Ser Gln Ser Asn Cys Gln Gln Phe Leu Asn           
        595                 600                 605                       

act gtt tgg ttt gga cag atg tcg ggt tac cga cgc aag ccc acc tgt       1872
Thr Val Trp Phe Gly Gln Met Ser Gly Tyr Arg Arg Lys Pro Thr Cys           
    610                 615                 620                           

aag aag ata atg act gtt ttg aca gta ggc atc ttt tgg cca gtt ttg       1920
Lys Lys Ile Met Thr Val Leu Thr Val Gly Ile Phe Trp Pro Val Leu           
625                 630                 635                 640           

tca ctt tgt tat ttg ata gct ccc aaa tct cag ttt ggc aga atc att       1968
Ser Leu Cys Tyr Leu Ile Ala Pro Lys Ser Gln Phe Gly Arg Ile Ile           
                645                 650                 655               

cac aca cct ttt atg aaa ttt atc att cat gga gca tca tat ttc aca       2016
His Thr Pro Phe Met Lys Phe Ile Ile His Gly Ala Ser Tyr Phe Thr           
            660                 665                 670                   

ttt ctg ctg ttg ctt aat cta tac tct ctt gtc tac aat gag gat aag       2064
Phe Leu Leu Leu Leu Asn Leu Tyr Ser Leu Val Tyr Asn Glu Asp Lys           
        675                 680                 685                       

aaa aac aca atg ggg cca gcc ctt gaa aga ata gac tat ctt ctt att       2112
Lys Asn Thr Met Gly Pro Ala Leu Glu Arg Ile Asp Tyr Leu Leu Ile           
    690                 695                 700                           

ctg tgg att att ggg atg att tgg tca gac att aaa aga ctc tgg tat       2160
Leu Trp Ile Ile Gly Met Ile Trp Ser Asp Ile Lys Arg Leu Trp Tyr           
705                 710                 715                 720           

gaa ggg ttg gaa gac ttt tta gaa gaa tct cgt aat caa ctc agt ttt       2208
Glu Gly Leu Glu Asp Phe Leu Glu Glu Ser Arg Asn Gln Leu Ser Phe           
                725                 730                 735               

gtc atg aat tct ctt tat ttg gca acc ttt gcc ctc aaa gtg gtt gct       2256
Val Met Asn Ser Leu Tyr Leu Ala Thr Phe Ala Leu Lys Val Val Ala           
            740                 745                 750                   

cac aac aag ttt cat gat ttt gct gat cgg aag gat tgg gat gca ttc       2304
His Asn Lys Phe His Asp Phe Ala Asp Arg Lys Asp Trp Asp Ala Phe           
        755                 760                 765                       

cat cct aca ctg gtg gca gaa ggg ctt ttt gca ttt gca aat gtt cta       2352
His Pro Thr Leu Val Ala Glu Gly Leu Phe Ala Phe Ala Asn Val Leu           
    770                 775                 780                           

agt tat ctt cgt ctc ttt ttt atg tat aca acc agc tct atc ttg ggt       2400
Ser Tyr Leu Arg Leu Phe Phe Met Tyr Thr Thr Ser Ser Ile Leu Gly           
785                 790                 795                 800           

cca tta cag att tca atg gga cag atg tta caa gat ttt gga aaa ttt       2448
Pro Leu Gln Ile Ser Met Gly Gln Met Leu Gln Asp Phe Gly Lys Phe           
                805                 810                 815               

ctt ggg atg ttt ctt ctt gtt ttg ttt tct ttc aca att gga ctg aca       2496
Leu Gly Met Phe Leu Leu Val Leu Phe Ser Phe Thr Ile Gly Leu Thr           
            820                 825                 830                   

caa ctg tat gat aaa gga tat act tca aag gag cag aag gac tgt gta       2544
Gln Leu Tyr Asp Lys Gly Tyr Thr Ser Lys Glu Gln Lys Asp Cys Val           
        835                 840                 845                       

ggc atc ttc tgt gaa cag caa agc aat gat acc ttc cat tcg ttc att       2592
Gly Ile Phe Cys Glu Gln Gln Ser Asn Asp Thr Phe His Ser Phe Ile           
    850                 855                 860                           

ggc acc tgc ttt gct ttg ttc tgg tat att ttc tcc tta gcg cat gtg       2640
Gly Thr Cys Phe Ala Leu Phe Trp Tyr Ile Phe Ser Leu Ala His Val           
865                 870                 875                 880           

gca atc ttt gtc aca aga ttt agc tat gga gaa gaa ctg cag tcc ttt       2688
Ala Ile Phe Val Thr Arg Phe Ser Tyr Gly Glu Glu Leu Gln Ser Phe           
                885                 890                 895               

gtg gga gct gtc att gtt ggt aca tac aat gtc gtg gtt gtg att gtg       2736
Val Gly Ala Val Ile Val Gly Thr Tyr Asn Val Val Val Val Ile Val           
            900                 905                 910                   

ctt acc aaa ctg ctg gtg gca atg ctt cat aaa agc ttt cag ttg ata       2784
Leu Thr Lys Leu Leu Val Ala Met Leu His Lys Ser Phe Gln Leu Ile           
        915                 920                 925                       

gca aat cat gaa gac aaa gaa tgg aag ttt gct cga gca aaa tta tgg       2832
Ala Asn His Glu Asp Lys Glu Trp Lys Phe Ala Arg Ala Lys Leu Trp           
    930                 935                 940                           

ctt agc tac ttt gat gac aaa tgt acg tta cct cca cct ttc aac atc       2880
Leu Ser Tyr Phe Asp Asp Lys Cys Thr Leu Pro Pro Pro Phe Asn Ile           
945                 950                 955                 960           

att ccc tca cca aag act atc tgc tat atg att agt agc ctc agt aag       2928
Ile Pro Ser Pro Lys Thr Ile Cys Tyr Met Ile Ser Ser Leu Ser Lys           
                965                 970                 975               

tgg att tgc tct cat aca tca aaa ggc aag gtc aaa cgg caa aac agt       2976
Trp Ile Cys Ser His Thr Ser Lys Gly Lys Val Lys Arg Gln Asn Ser           
            980                 985                 990                   

tta aag gaa tgg agg aat ttg aaa  cag aag aga gat gaa  aac tat caa     3024
Leu Lys Glu Trp Arg Asn Leu Lys  Gln Lys Arg Asp Glu  Asn Tyr Gln         
        995                 1000                 1005                     

aaa gtg  atg tgc tgc cta gtg  cat cgt tac ttg act  tcc atg aga        3069
Lys Val  Met Cys Cys Leu Val  His Arg Tyr Leu Thr  Ser Met Arg            
    1010                 1015                 1020                        

cag aag  atg caa agt aca gat  cag gca act gtg gaa  aat cta aac        3114
Gln Lys  Met Gln Ser Thr Asp  Gln Ala Thr Val Glu  Asn Leu Asn            
    1025                 1030                 1035                        

gaa ctg  cgc caa gat ctg tca  aaa ttc cga aat gaa  ata agg gat        3159
Glu Leu  Arg Gln Asp Leu Ser  Lys Phe Arg Asn Glu  Ile Arg Asp            
    1040                 1045                 1050                        

tta ctt  ggc ttt cgg act tct  aaa tat gct atg ttt  tat cca aga        3204
Leu Leu  Gly Phe Arg Thr Ser  Lys Tyr Ala Met Phe  Tyr Pro Arg            
    1055                 1060                 1065                        

aat gaa  caa aaa ctc atc tca  gaa gag gat ctg taa                     3240
Asn Glu  Gln Lys Leu Ile Ser  Glu Glu Asp Leu                             
    1070                 1075                                             


<210>  10
<211>  1079
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  10

Met Ser Pro Glu Asp Glu Ile Gln Gln Leu Glu Glu Glu Ile Ala Gln 
1               5                   10                  15      


Leu Glu Gln Lys Asn Ala Ala Leu Lys Glu Lys Asn Gln Ala Leu Lys 
            20                  25                  30          


Tyr Gly Gly Ser Gly Leu Gly Ile Trp Thr Leu Leu Pro Leu Val Leu 
        35                  40                  45              


Thr Ser Val Ala Arg Leu Ser Ser Lys Ser Val Asn Ala Tyr Pro Tyr 
    50                  55                  60                  


Asp Val Pro Asp Tyr Ala Gln Val Thr Asp Ile Asn Ser Lys Gly Leu 
65                  70                  75                  80  


Glu Leu Arg Lys Thr Val Thr Thr Val Glu Thr Gln Asn Leu Glu Gly 
                85                  90                  95      


Leu His His Asp Gly Gln Phe Cys His Lys Pro Cys Pro Pro Gly Glu 
            100                 105                 110         


Arg Lys Ala Arg Asp Cys Thr Val Asn Gly Asp Glu Pro Asp Cys Val 
        115                 120                 125             


Pro Cys Gln Glu Gly Lys Glu Tyr Thr Asp Lys Ala His Phe Ser Ser 
    130                 135                 140                 


Lys Cys Arg Arg Cys Arg Leu Cys Asp Glu Gly His Gly Leu Glu Val 
145                 150                 155                 160 


Glu Ile Asn Cys Thr Arg Thr Gln Asn Thr Lys Cys Arg Cys Lys Pro 
                165                 170                 175     


Asn Phe Phe Cys Asn Ser Thr Val Cys Glu His Cys Asp Pro Cys Thr 
            180                 185                 190         


Lys Cys Glu His Gly Ile Ile Lys Glu Cys Thr Leu Thr Ser Asn Thr 
        195                 200                 205             


Lys Cys Lys Glu Glu Gly Ser Arg Ser Asn Leu Gly Trp Leu Cys Leu 
    210                 215                 220                 


Leu Leu Leu Pro Ile Pro Leu Ile Val Trp Val Lys Arg Lys Glu Val 
225                 230                 235                 240 


Gln Lys Thr Cys Arg Lys His Arg Lys Glu Asn Gln Gly Ser His Glu 
                245                 250                 255     


Ser Pro Thr Leu Asn Pro Glu Thr Val Ala Ile Asn Leu Gly Ser Gly 
            260                 265                 270         


Tyr Pro Tyr Asp Val Pro Asp Tyr Ala Gly Gly Ser Gly Gly Gly Ser 
        275                 280                 285             


Gly Gly Ser Gly Gly Ser Gly Gly Gly Ser Gly Gly Ser Gly Gly Ser 
    290                 295                 300                 


Gly Gly Gly Ser Gly Gly Ser Met Ala Ala Leu Tyr Pro Ser Thr Asp 
305                 310                 315                 320 


Leu Ser Gly Ala Ser Ser Ser Ser Leu Pro Ser Ser Pro Ser Ser Ser 
                325                 330                 335     


Ser Pro Asn Glu Val Met Ala Leu Lys Asp Val Arg Glu Val Lys Glu 
            340                 345                 350         


Glu Asn Thr Leu Asn Glu Lys Leu Phe Leu Leu Ala Cys Asp Lys Gly 
        355                 360                 365             


Asp Tyr Tyr Met Val Lys Lys Ile Leu Glu Glu Asn Ser Ser Gly Asp 
    370                 375                 380                 


Leu Asn Ile Asn Cys Val Asp Val Leu Gly Arg Asn Ala Val Thr Ile 
385                 390                 395                 400 


Thr Ile Glu Asn Glu Asn Leu Asp Ile Leu Gln Leu Leu Leu Asp Tyr 
                405                 410                 415     


Gly Cys Gln Lys Leu Met Glu Arg Ile Gln Asn Pro Glu Tyr Ser Thr 
            420                 425                 430         


Thr Met Asp Val Ala Pro Val Ile Leu Ala Ala His Arg Asn Asn Tyr 
        435                 440                 445             


Glu Ile Leu Thr Met Leu Leu Lys Gln Asp Val Ser Leu Pro Lys Pro 
    450                 455                 460                 


His Ala Val Gly Cys Glu Cys Thr Leu Cys Ser Ala Lys Asn Lys Lys 
465                 470                 475                 480 


Asp Ser Leu Arg His Ser Arg Phe Arg Leu Asp Ile Tyr Arg Cys Leu 
                485                 490                 495     


Ala Ser Pro Ala Leu Ile Met Leu Thr Glu Glu Asp Pro Ile Leu Arg 
            500                 505                 510         


Ala Phe Glu Leu Ser Ala Asp Leu Lys Glu Leu Ser Leu Val Glu Val 
        515                 520                 525             


Glu Phe Arg Asn Asp Tyr Glu Glu Leu Ala Arg Gln Cys Lys Met Phe 
    530                 535                 540                 


Ala Lys Asp Leu Leu Ala Gln Ala Arg Asn Ser Arg Glu Leu Glu Val 
545                 550                 555                 560 


Ile Leu Asn His Thr Ser Ser Asp Glu Pro Leu Asp Lys Arg Gly Leu 
                565                 570                 575     


Leu Glu Glu Arg Met Asn Leu Ser Arg Leu Lys Leu Ala Ile Lys Tyr 
            580                 585                 590         


Asn Gln Lys Glu Phe Val Ser Gln Ser Asn Cys Gln Gln Phe Leu Asn 
        595                 600                 605             


Thr Val Trp Phe Gly Gln Met Ser Gly Tyr Arg Arg Lys Pro Thr Cys 
    610                 615                 620                 


Lys Lys Ile Met Thr Val Leu Thr Val Gly Ile Phe Trp Pro Val Leu 
625                 630                 635                 640 


Ser Leu Cys Tyr Leu Ile Ala Pro Lys Ser Gln Phe Gly Arg Ile Ile 
                645                 650                 655     


His Thr Pro Phe Met Lys Phe Ile Ile His Gly Ala Ser Tyr Phe Thr 
            660                 665                 670         


Phe Leu Leu Leu Leu Asn Leu Tyr Ser Leu Val Tyr Asn Glu Asp Lys 
        675                 680                 685             


Lys Asn Thr Met Gly Pro Ala Leu Glu Arg Ile Asp Tyr Leu Leu Ile 
    690                 695                 700                 


Leu Trp Ile Ile Gly Met Ile Trp Ser Asp Ile Lys Arg Leu Trp Tyr 
705                 710                 715                 720 


Glu Gly Leu Glu Asp Phe Leu Glu Glu Ser Arg Asn Gln Leu Ser Phe 
                725                 730                 735     


Val Met Asn Ser Leu Tyr Leu Ala Thr Phe Ala Leu Lys Val Val Ala 
            740                 745                 750         


His Asn Lys Phe His Asp Phe Ala Asp Arg Lys Asp Trp Asp Ala Phe 
        755                 760                 765             


His Pro Thr Leu Val Ala Glu Gly Leu Phe Ala Phe Ala Asn Val Leu 
    770                 775                 780                 


Ser Tyr Leu Arg Leu Phe Phe Met Tyr Thr Thr Ser Ser Ile Leu Gly 
785                 790                 795                 800 


Pro Leu Gln Ile Ser Met Gly Gln Met Leu Gln Asp Phe Gly Lys Phe 
                805                 810                 815     


Leu Gly Met Phe Leu Leu Val Leu Phe Ser Phe Thr Ile Gly Leu Thr 
            820                 825                 830         


Gln Leu Tyr Asp Lys Gly Tyr Thr Ser Lys Glu Gln Lys Asp Cys Val 
        835                 840                 845             


Gly Ile Phe Cys Glu Gln Gln Ser Asn Asp Thr Phe His Ser Phe Ile 
    850                 855                 860                 


Gly Thr Cys Phe Ala Leu Phe Trp Tyr Ile Phe Ser Leu Ala His Val 
865                 870                 875                 880 


Ala Ile Phe Val Thr Arg Phe Ser Tyr Gly Glu Glu Leu Gln Ser Phe 
                885                 890                 895     


Val Gly Ala Val Ile Val Gly Thr Tyr Asn Val Val Val Val Ile Val 
            900                 905                 910         


Leu Thr Lys Leu Leu Val Ala Met Leu His Lys Ser Phe Gln Leu Ile 
        915                 920                 925             


Ala Asn His Glu Asp Lys Glu Trp Lys Phe Ala Arg Ala Lys Leu Trp 
    930                 935                 940                 


Leu Ser Tyr Phe Asp Asp Lys Cys Thr Leu Pro Pro Pro Phe Asn Ile 
945                 950                 955                 960 


Ile Pro Ser Pro Lys Thr Ile Cys Tyr Met Ile Ser Ser Leu Ser Lys 
                965                 970                 975     


Trp Ile Cys Ser His Thr Ser Lys Gly Lys Val Lys Arg Gln Asn Ser 
            980                 985                 990         


Leu Lys Glu Trp Arg Asn Leu Lys  Gln Lys Arg Asp Glu  Asn Tyr Gln 
        995                 1000                 1005             


Lys Val  Met Cys Cys Leu Val  His Arg Tyr Leu Thr  Ser Met Arg 
    1010                 1015                 1020             


Gln Lys  Met Gln Ser Thr Asp  Gln Ala Thr Val Glu  Asn Leu Asn 
    1025                 1030                 1035             


Glu Leu  Arg Gln Asp Leu Ser  Lys Phe Arg Asn Glu  Ile Arg Asp 
    1040                 1045                 1050             


Leu Leu  Gly Phe Arg Thr Ser  Lys Tyr Ala Met Phe  Tyr Pro Arg 
    1055                 1060                 1065             


Asn Glu  Gln Lys Leu Ile Ser  Glu Glu Asp Leu 
    1070                 1075                 


<210>  11
<211>  1623
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  -


<220>
<221>  CDS
<222>  (1)..(42)
<223>  Myc

<220>
<221>  CDS
<222>  (43)..(1512)
<223>  nLuc

<220>
<221>  CDS
<222>  (1513)..(1542)
<223>  GS10

<220>
<221>  CDS
<222>  (1543)..(1620)
<223>  M13

<400>  11
atg gag cag aag ctg atc agc gag gag gac ctg ggt tct gga gaa gat         48
Met Glu Gln Lys Leu Ile Ser Glu Glu Asp Leu Gly Ser Gly Glu Asp           
1               5                   10                  15                

gcc aaa aac att aag aag ggc cca gcg cca ttc tac cca ctc gaa gac         96
Ala Lys Asn Ile Lys Lys Gly Pro Ala Pro Phe Tyr Pro Leu Glu Asp           
            20                  25                  30                    

ggg acc gcc ggc gag cag ctg cac aaa gcc atg aag cgc tac gcc ctg        144
Gly Thr Ala Gly Glu Gln Leu His Lys Ala Met Lys Arg Tyr Ala Leu           
        35                  40                  45                        

gtg ccc ggc acc atc gcc ttt acc gac gca cat atc gag gtg gac att        192
Val Pro Gly Thr Ile Ala Phe Thr Asp Ala His Ile Glu Val Asp Ile           
    50                  55                  60                            

acc tac gcc gag tac ttc gag atg agc gtt cgg ctg gca gaa gct atg        240
Thr Tyr Ala Glu Tyr Phe Glu Met Ser Val Arg Leu Ala Glu Ala Met           
65                  70                  75                  80            

aag cgc tat ggg ctg aat aca aac cat cgg atc gtg gtg tgc agc gag        288
Lys Arg Tyr Gly Leu Asn Thr Asn His Arg Ile Val Val Cys Ser Glu           
                85                  90                  95                

aat agc ttg cag ttc ttc atg ccc gtg ttg ggt gcc ctg ttc atc ggt        336
Asn Ser Leu Gln Phe Phe Met Pro Val Leu Gly Ala Leu Phe Ile Gly           
            100                 105                 110                   

gtg gct gtg gcc cca gct aac gac atc tac aac gag cgc gag ctg ctg        384
Val Ala Val Ala Pro Ala Asn Asp Ile Tyr Asn Glu Arg Glu Leu Leu           
        115                 120                 125                       

aac agc atg ggc atc agc cag ccc acc gtc gta ttc gtg agc aag aaa        432
Asn Ser Met Gly Ile Ser Gln Pro Thr Val Val Phe Val Ser Lys Lys           
    130                 135                 140                           

ggg ctg caa aag atc ctc aac gtg caa aag aag cta ccg atc ata caa        480
Gly Leu Gln Lys Ile Leu Asn Val Gln Lys Lys Leu Pro Ile Ile Gln           
145                 150                 155                 160           

aag atc atc atc atg gat agc aag acc gac tac cag ggc ttc caa agc        528
Lys Ile Ile Ile Met Asp Ser Lys Thr Asp Tyr Gln Gly Phe Gln Ser           
                165                 170                 175               

atg tac acc ttc gtg act tcc cat ttg cca ccc ggc ttc aac gag tac        576
Met Tyr Thr Phe Val Thr Ser His Leu Pro Pro Gly Phe Asn Glu Tyr           
            180                 185                 190                   

gac ttc gtg ccc gag agc ttc gac cgg gac aaa acc atc gcc ctg atc        624
Asp Phe Val Pro Glu Ser Phe Asp Arg Asp Lys Thr Ile Ala Leu Ile           
        195                 200                 205                       

atg aac agt agt ggc agt acc gga ttg ccc aag ggc gta gcc cta ccg        672
Met Asn Ser Ser Gly Ser Thr Gly Leu Pro Lys Gly Val Ala Leu Pro           
    210                 215                 220                           

cac cgc acc gct tgt gtc cga ttc agt cat gcc cgc gac ccc atc ttc        720
His Arg Thr Ala Cys Val Arg Phe Ser His Ala Arg Asp Pro Ile Phe           
225                 230                 235                 240           

ggc aac cag atc atc ccc gac acc gct atc ctc agc gtg gtg cca ttt        768
Gly Asn Gln Ile Ile Pro Asp Thr Ala Ile Leu Ser Val Val Pro Phe           
                245                 250                 255               

cac cac ggc ttc ggc atg ttc acc acg ctg ggc tac ttg atc tgc ggc        816
His His Gly Phe Gly Met Phe Thr Thr Leu Gly Tyr Leu Ile Cys Gly           
            260                 265                 270                   

ttt cgg gtc gtg ctc atg tac cgc ttc gag gag gag cta ttc ttg cgc        864
Phe Arg Val Val Leu Met Tyr Arg Phe Glu Glu Glu Leu Phe Leu Arg           
        275                 280                 285                       

agc ttg caa gac tat aag att caa tct gcc ctg ctg gtg ccc aca cta        912
Ser Leu Gln Asp Tyr Lys Ile Gln Ser Ala Leu Leu Val Pro Thr Leu           
    290                 295                 300                           

ttt agc ttc ttc gct aag agc act ctc atc gac aag tac gac cta agc        960
Phe Ser Phe Phe Ala Lys Ser Thr Leu Ile Asp Lys Tyr Asp Leu Ser           
305                 310                 315                 320           

aac ttg cac gag atc gcc agc ggc ggg gcg ccg ctc agc aag gag gta       1008
Asn Leu His Glu Ile Ala Ser Gly Gly Ala Pro Leu Ser Lys Glu Val           
                325                 330                 335               

ggt gag gcc gtg gcc aaa cgc ttc cac cta cca ggc atc cgc cag ggc       1056
Gly Glu Ala Val Ala Lys Arg Phe His Leu Pro Gly Ile Arg Gln Gly           
            340                 345                 350                   

tac ggc ctg aca gaa aca acc agc gcc att ctg atc acc ccc gaa ggg       1104
Tyr Gly Leu Thr Glu Thr Thr Ser Ala Ile Leu Ile Thr Pro Glu Gly           
        355                 360                 365                       

gac gac aag cct ggc gca gta ggc aag gtg gtg ccc ttc ttc gag gct       1152
Asp Asp Lys Pro Gly Ala Val Gly Lys Val Val Pro Phe Phe Glu Ala           
    370                 375                 380                           

aag gtg gtg gac ttg gac acc ggt aag aca ctg ggt gtg aac cag cgc       1200
Lys Val Val Asp Leu Asp Thr Gly Lys Thr Leu Gly Val Asn Gln Arg           
385                 390                 395                 400           

ggc gag ctg tgc gtc cgt ggc ccc atg atc atg agc ggc tac gtt aac       1248
Gly Glu Leu Cys Val Arg Gly Pro Met Ile Met Ser Gly Tyr Val Asn           
                405                 410                 415               

aac ccc gag gct aca aac gct ctc atc gac aag gac ggc tgg ctg cac       1296
Asn Pro Glu Ala Thr Asn Ala Leu Ile Asp Lys Asp Gly Trp Leu His           
            420                 425                 430                   

agc ggc gac atc gcc tac tgg gac gag gac gag cac ttc ttc atc gtg       1344
Ser Gly Asp Ile Ala Tyr Trp Asp Glu Asp Glu His Phe Phe Ile Val           
        435                 440                 445                       

gac cgg ctg aag agc ctg atc aaa tac aag ggc tac cag gta gcc cca       1392
Asp Arg Leu Lys Ser Leu Ile Lys Tyr Lys Gly Tyr Gln Val Ala Pro           
    450                 455                 460                           

gcc gaa ctg gag agc atc ctg ctg caa cac ccc aac atc ttc gac gcc       1440
Ala Glu Leu Glu Ser Ile Leu Leu Gln His Pro Asn Ile Phe Asp Ala           
465                 470                 475                 480           

ggg gtc gcc ggc ctg ccc gac gac gat gcc ggc gag ctg ccc gcc gca       1488
Gly Val Ala Gly Leu Pro Asp Asp Asp Ala Gly Glu Leu Pro Ala Ala           
                485                 490                 495               

gtc gtc gtg ctg gaa cac ggt aaa ggc ggc tct ggc ggc ggc tcc gga       1536
Val Val Val Leu Glu His Gly Lys Gly Gly Ser Gly Gly Gly Ser Gly           
            500                 505                 510                   

ggc tct aag agg cgc tgg aag aaa aac ttc att gcc gtc agc gct gcc       1584
Gly Ser Lys Arg Arg Trp Lys Lys Asn Phe Ile Ala Val Ser Ala Ala           
        515                 520                 525                       

aac cgc ttc aag aag atc agc agc tcc ggg gca ctg taa                   1623
Asn Arg Phe Lys Lys Ile Ser Ser Ser Gly Ala Leu                           
    530                 535                 540                           


<210>  12
<211>  540
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  12

Met Glu Gln Lys Leu Ile Ser Glu Glu Asp Leu Gly Ser Gly Glu Asp 
1               5                   10                  15      


Ala Lys Asn Ile Lys Lys Gly Pro Ala Pro Phe Tyr Pro Leu Glu Asp 
            20                  25                  30          


Gly Thr Ala Gly Glu Gln Leu His Lys Ala Met Lys Arg Tyr Ala Leu 
        35                  40                  45              


Val Pro Gly Thr Ile Ala Phe Thr Asp Ala His Ile Glu Val Asp Ile 
    50                  55                  60                  


Thr Tyr Ala Glu Tyr Phe Glu Met Ser Val Arg Leu Ala Glu Ala Met 
65                  70                  75                  80  


Lys Arg Tyr Gly Leu Asn Thr Asn His Arg Ile Val Val Cys Ser Glu 
                85                  90                  95      


Asn Ser Leu Gln Phe Phe Met Pro Val Leu Gly Ala Leu Phe Ile Gly 
            100                 105                 110         


Val Ala Val Ala Pro Ala Asn Asp Ile Tyr Asn Glu Arg Glu Leu Leu 
        115                 120                 125             


Asn Ser Met Gly Ile Ser Gln Pro Thr Val Val Phe Val Ser Lys Lys 
    130                 135                 140                 


Gly Leu Gln Lys Ile Leu Asn Val Gln Lys Lys Leu Pro Ile Ile Gln 
145                 150                 155                 160 


Lys Ile Ile Ile Met Asp Ser Lys Thr Asp Tyr Gln Gly Phe Gln Ser 
                165                 170                 175     


Met Tyr Thr Phe Val Thr Ser His Leu Pro Pro Gly Phe Asn Glu Tyr 
            180                 185                 190         


Asp Phe Val Pro Glu Ser Phe Asp Arg Asp Lys Thr Ile Ala Leu Ile 
        195                 200                 205             


Met Asn Ser Ser Gly Ser Thr Gly Leu Pro Lys Gly Val Ala Leu Pro 
    210                 215                 220                 


His Arg Thr Ala Cys Val Arg Phe Ser His Ala Arg Asp Pro Ile Phe 
225                 230                 235                 240 


Gly Asn Gln Ile Ile Pro Asp Thr Ala Ile Leu Ser Val Val Pro Phe 
                245                 250                 255     


His His Gly Phe Gly Met Phe Thr Thr Leu Gly Tyr Leu Ile Cys Gly 
            260                 265                 270         


Phe Arg Val Val Leu Met Tyr Arg Phe Glu Glu Glu Leu Phe Leu Arg 
        275                 280                 285             


Ser Leu Gln Asp Tyr Lys Ile Gln Ser Ala Leu Leu Val Pro Thr Leu 
    290                 295                 300                 


Phe Ser Phe Phe Ala Lys Ser Thr Leu Ile Asp Lys Tyr Asp Leu Ser 
305                 310                 315                 320 


Asn Leu His Glu Ile Ala Ser Gly Gly Ala Pro Leu Ser Lys Glu Val 
                325                 330                 335     


Gly Glu Ala Val Ala Lys Arg Phe His Leu Pro Gly Ile Arg Gln Gly 
            340                 345                 350         


Tyr Gly Leu Thr Glu Thr Thr Ser Ala Ile Leu Ile Thr Pro Glu Gly 
        355                 360                 365             


Asp Asp Lys Pro Gly Ala Val Gly Lys Val Val Pro Phe Phe Glu Ala 
    370                 375                 380                 


Lys Val Val Asp Leu Asp Thr Gly Lys Thr Leu Gly Val Asn Gln Arg 
385                 390                 395                 400 


Gly Glu Leu Cys Val Arg Gly Pro Met Ile Met Ser Gly Tyr Val Asn 
                405                 410                 415     


Asn Pro Glu Ala Thr Asn Ala Leu Ile Asp Lys Asp Gly Trp Leu His 
            420                 425                 430         


Ser Gly Asp Ile Ala Tyr Trp Asp Glu Asp Glu His Phe Phe Ile Val 
        435                 440                 445             


Asp Arg Leu Lys Ser Leu Ile Lys Tyr Lys Gly Tyr Gln Val Ala Pro 
    450                 455                 460                 


Ala Glu Leu Glu Ser Ile Leu Leu Gln His Pro Asn Ile Phe Asp Ala 
465                 470                 475                 480 


Gly Val Ala Gly Leu Pro Asp Asp Asp Ala Gly Glu Leu Pro Ala Ala 
                485                 490                 495     


Val Val Val Leu Glu His Gly Lys Gly Gly Ser Gly Gly Gly Ser Gly 
            500                 505                 510         


Gly Ser Lys Arg Arg Trp Lys Lys Asn Phe Ile Ala Val Ser Ala Ala 
        515                 520                 525             


Asn Arg Phe Lys Lys Ile Ser Ser Ser Gly Ala Leu 
    530                 535                 540 


<210>  13
<211>  696
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  -


<220>
<221>  CDS
<222>  (1)..(444)
<223>  calmodulin

<220>
<221>  CDS
<222>  (445)..(474)
<223>  GS10

<220>
<221>  CDS
<222>  (475)..(668)
<223>  cepljena luciferaza

<220>
<221>  CDS
<222>  (669)..(693)
<223>  HA

<400>  13
atg gac caa ctg aca gaa gag cag att gca gag ttc aaa gaa gcc ttc         48
Met Asp Gln Leu Thr Glu Glu Gln Ile Ala Glu Phe Lys Glu Ala Phe           
1               5                   10                  15                

tca tta ttc gac aag gat ggg gac ggc acc atc acc aca aag gaa ctt         96
Ser Leu Phe Asp Lys Asp Gly Asp Gly Thr Ile Thr Thr Lys Glu Leu           
            20                  25                  30                    

ggc acc gtt atg agg tcg ctt gga caa aac cca acg gaa gca gaa ttg        144
Gly Thr Val Met Arg Ser Leu Gly Gln Asn Pro Thr Glu Ala Glu Leu           
        35                  40                  45                        

cag gat atg atc aat gaa gtc gat gct gat ggc aat gga acg att tac        192
Gln Asp Met Ile Asn Glu Val Asp Ala Asp Gly Asn Gly Thr Ile Tyr           
    50                  55                  60                            

ttt cct gaa ttt ctt act atg atg gct aga aaa atg aag gac aca gac        240
Phe Pro Glu Phe Leu Thr Met Met Ala Arg Lys Met Lys Asp Thr Asp           
65                  70                  75                  80            

agc gaa gag gaa atc cga gaa gca ttc cgt gtt ttt gac aag gat ggg        288
Ser Glu Glu Glu Ile Arg Glu Ala Phe Arg Val Phe Asp Lys Asp Gly           
                85                  90                  95                

aac ggc tat atc agt gct gct cag tta cgt cat gtg atg aca aac ctt        336
Asn Gly Tyr Ile Ser Ala Ala Gln Leu Arg His Val Met Thr Asn Leu           
            100                 105                 110                   

ggg gag aag tta aca gat gaa gaa gtt gat gaa atg ata agg gaa gca        384
Gly Glu Lys Leu Thr Asp Glu Glu Val Asp Glu Met Ile Arg Glu Ala           
        115                 120                 125                       

gat att gat gga gat ggc caa gta aac tat gaa gag ttt gta caa atg        432
Asp Ile Asp Gly Asp Gly Gln Val Asn Tyr Glu Glu Phe Val Gln Met           
    130                 135                 140                           

atg aca gca aag ggc ggc tct ggc ggc ggc tcc gga ggc tct acc atg        480
Met Thr Ala Lys Gly Gly Ser Gly Gly Gly Ser Gly Gly Ser Thr Met           
145                 150                 155                 160           

acc gag aag gag atc gtg gac tat gtg gcc agc cag gtt aca acc gcc        528
Thr Glu Lys Glu Ile Val Asp Tyr Val Ala Ser Gln Val Thr Thr Ala           
                165                 170                 175               

aag aag ctg cgc ggt ggt gtt gtg ttc gtg gac gag gtg cct aaa gga        576
Lys Lys Leu Arg Gly Gly Val Val Phe Val Asp Glu Val Pro Lys Gly           
            180                 185                 190                   

ctg acc ggc aag ttg gac gcc cgc aag atc cgc gag att ctc att aag        624
Leu Thr Gly Lys Leu Asp Ala Arg Lys Ile Arg Glu Ile Leu Ile Lys           
        195                 200                 205                       

gcc aag aag ggc ggc aag atc gcc gtg aat agt ggt tct gga ta  c cca      672
Ala Lys Lys Gly Gly Lys Ile Ala Val Asn Ser Gly Ser Gly Tyr   Pro         
    210                 215                 220                           

tac gat gtt cca gat tac gct taa                                        696
Tyr Asp Val Pro Asp Tyr Ala                                               
225                 230                                                   


<210>  14
<211>  231
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  14

Met Asp Gln Leu Thr Glu Glu Gln Ile Ala Glu Phe Lys Glu Ala Phe 
1               5                   10                  15      


Ser Leu Phe Asp Lys Asp Gly Asp Gly Thr Ile Thr Thr Lys Glu Leu 
            20                  25                  30          


Gly Thr Val Met Arg Ser Leu Gly Gln Asn Pro Thr Glu Ala Glu Leu 
        35                  40                  45              


Gln Asp Met Ile Asn Glu Val Asp Ala Asp Gly Asn Gly Thr Ile Tyr 
    50                  55                  60                  


Phe Pro Glu Phe Leu Thr Met Met Ala Arg Lys Met Lys Asp Thr Asp 
65                  70                  75                  80  


Ser Glu Glu Glu Ile Arg Glu Ala Phe Arg Val Phe Asp Lys Asp Gly 
                85                  90                  95      


Asn Gly Tyr Ile Ser Ala Ala Gln Leu Arg His Val Met Thr Asn Leu 
            100                 105                 110         


Gly Glu Lys Leu Thr Asp Glu Glu Val Asp Glu Met Ile Arg Glu Ala 
        115                 120                 125             


Asp Ile Asp Gly Asp Gly Gln Val Asn Tyr Glu Glu Phe Val Gln Met 
    130                 135                 140                 


Met Thr Ala Lys Gly Gly Ser Gly Gly Gly Ser Gly Gly Ser Thr Met 
145                 150                 155                 160 


Thr Glu Lys Glu Ile Val Asp Tyr Val Ala Ser Gln Val Thr Thr Ala 
                165                 170                 175     


Lys Lys Leu Arg Gly Gly Val Val Phe Val Asp Glu Val Pro Lys Gly 
            180                 185                 190         


Leu Thr Gly Lys Leu Asp Ala Arg Lys Ile Arg Glu Ile Leu Ile Lys 
        195                 200                 205             


Ala Lys Lys Gly Gly Lys Ile Ala Val Asn Ser Gly Ser Gly Tyr Pro 
    210                 215                 220                 


Tyr Asp Val Pro Asp Tyr Ala 
225                 230     


<210>  15
<211>  2181
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (1)..(33)
<223>  Myc

<220>
<221>  CDS
<222>  (34)..(2178)
<223>  NFAT

<400>  15
atg gag cag aag ctg atc agc gag gag gac ctg ccc agc acc agc ttc         48
Met Glu Gln Lys Leu Ile Ser Glu Glu Asp Leu Pro Ser Thr Ser Phe           
1               5                   10                  15                

ccc gtg ccc agc aag ttc ccc ctg ggc ccc gcc gcc gcc gtg ttc ggc         96
Pro Val Pro Ser Lys Phe Pro Leu Gly Pro Ala Ala Ala Val Phe Gly           
            20                  25                  30                    

agg ggc gag acc ctg ggc ccc gcc ccc agg gcc ggc ggc acc atg aag        144
Arg Gly Glu Thr Leu Gly Pro Ala Pro Arg Ala Gly Gly Thr Met Lys           
        35                  40                  45                        

agc gcc gag gag gag cac tac ggc tac gcc agc agc aac gtg agc ccc        192
Ser Ala Glu Glu Glu His Tyr Gly Tyr Ala Ser Ser Asn Val Ser Pro           
    50                  55                  60                            

gcc ctg ccc ctg ccc acc gcc cac agc acc ctg ccc gcc ccc tgc cac        240
Ala Leu Pro Leu Pro Thr Ala His Ser Thr Leu Pro Ala Pro Cys His           
65                  70                  75                  80            

aac ctc cag acc agc acc ccc ggc atc atc ccc ccc gcc gac cac ccc        288
Asn Leu Gln Thr Ser Thr Pro Gly Ile Ile Pro Pro Ala Asp His Pro           
                85                  90                  95                

agc ggc tac ggc gcc gcc ctg gac ggc ggc ccc gcc ggc tac ttc ctg        336
Ser Gly Tyr Gly Ala Ala Leu Asp Gly Gly Pro Ala Gly Tyr Phe Leu           
            100                 105                 110                   

agc agc ggc cac acc agg ccc gac ggc gcc ccc gcc ctg gag agc ccc        384
Ser Ser Gly His Thr Arg Pro Asp Gly Ala Pro Ala Leu Glu Ser Pro           
        115                 120                 125                       

agg atc gag atc acc agc tgc ctg ggc ctg tac cac aac aac aac cag        432
Arg Ile Glu Ile Thr Ser Cys Leu Gly Leu Tyr His Asn Asn Asn Gln           
    130                 135                 140                           

ttc ttc cac gac gtg gag gtg gag gac gtg ctg ccc agc agc aag agg        480
Phe Phe His Asp Val Glu Val Glu Asp Val Leu Pro Ser Ser Lys Arg           
145                 150                 155                 160           

agc ccc agc acc gcc acc ctg agc ctg ccc agc ctg gag gcc tac agg        528
Ser Pro Ser Thr Ala Thr Leu Ser Leu Pro Ser Leu Glu Ala Tyr Arg           
                165                 170                 175               

gac ccc agc tgc ctg agc ccc gcc agc agc ctg agc agc agg agc tgc        576
Asp Pro Ser Cys Leu Ser Pro Ala Ser Ser Leu Ser Ser Arg Ser Cys           
            180                 185                 190                   

aac agc gag gcc agc agc tac gag agc aac tac agc tac ccc tac gcc        624
Asn Ser Glu Ala Ser Ser Tyr Glu Ser Asn Tyr Ser Tyr Pro Tyr Ala           
        195                 200                 205                       

agc ccc cag acc agc ccc tgg cag agc ccc tgc gtg agc ccc aag acc        672
Ser Pro Gln Thr Ser Pro Trp Gln Ser Pro Cys Val Ser Pro Lys Thr           
    210                 215                 220                           

acc gac ccc gag gag ggc ttc ccc agg ggc ctg ggc gcc tgc acc ctg        720
Thr Asp Pro Glu Glu Gly Phe Pro Arg Gly Leu Gly Ala Cys Thr Leu           
225                 230                 235                 240           

ctg ggc agc ccc agg cac agc ccc agc acc agc ccc agg gcc agc gtg        768
Leu Gly Ser Pro Arg His Ser Pro Ser Thr Ser Pro Arg Ala Ser Val           
                245                 250                 255               

acc gag gag agc tgg ctg ggc gcc agg agc agc agg ccc gcc agc ccc        816
Thr Glu Glu Ser Trp Leu Gly Ala Arg Ser Ser Arg Pro Ala Ser Pro           
            260                 265                 270                   

tgc aac aag agg aag tac agc ctg aac ggc agg cag ccc ccc tac agc        864
Cys Asn Lys Arg Lys Tyr Ser Leu Asn Gly Arg Gln Pro Pro Tyr Ser           
        275                 280                 285                       

ccc cac cac agc ccc acc ccc agc ccc cac ggc agc ccc agg gtg agc        912
Pro His His Ser Pro Thr Pro Ser Pro His Gly Ser Pro Arg Val Ser           
    290                 295                 300                           

gtg acc gac gac agc tgg ctg ggc aac acc acc cag tac acc agc agc        960
Val Thr Asp Asp Ser Trp Leu Gly Asn Thr Thr Gln Tyr Thr Ser Ser           
305                 310                 315                 320           

gcc atc gtg gcc gcc atc aac gcc ctg acc acc gac agc agc ctg gac       1008
Ala Ile Val Ala Ala Ile Asn Ala Leu Thr Thr Asp Ser Ser Leu Asp           
                325                 330                 335               

ctg ggc gac ggc gtg ccc gtg aag agc agg aag acc acc ctg gag cag       1056
Leu Gly Asp Gly Val Pro Val Lys Ser Arg Lys Thr Thr Leu Glu Gln           
            340                 345                 350                   

ccc ccc agc gtg gcc ctg aag gtg gag ccc gtg ggc gag gac ctg ggc       1104
Pro Pro Ser Val Ala Leu Lys Val Glu Pro Val Gly Glu Asp Leu Gly           
        355                 360                 365                       

agc ccc ccc ccc ccc gcc gac ttc gcc ccc gag gac tac agc agc ttc       1152
Ser Pro Pro Pro Pro Ala Asp Phe Ala Pro Glu Asp Tyr Ser Ser Phe           
    370                 375                 380                           

cag cac atc agg aag ggc ggc ttc tgc gac cag tac ctg gcc gtg ccc       1200
Gln His Ile Arg Lys Gly Gly Phe Cys Asp Gln Tyr Leu Ala Val Pro           
385                 390                 395                 400           

cag cac ccc tac cag tgg gcc aag ccc aag ccc ctg agc ccc acc agc       1248
Gln His Pro Tyr Gln Trp Ala Lys Pro Lys Pro Leu Ser Pro Thr Ser           
                405                 410                 415               

tac atg agc ccc acc ctg ccc gcc ctg gac tgg cag ctg ccc agc cac       1296
Tyr Met Ser Pro Thr Leu Pro Ala Leu Asp Trp Gln Leu Pro Ser His           
            420                 425                 430                   

agc ggc ccc tac gag ctg agg atc gag gtg cag ccc aag agc cac cac       1344
Ser Gly Pro Tyr Glu Leu Arg Ile Glu Val Gln Pro Lys Ser His His           
        435                 440                 445                       

agg gcc cac tac gag acc gag ggc agc agg ggc gcc gtg aag gcc agc       1392
Arg Ala His Tyr Glu Thr Glu Gly Ser Arg Gly Ala Val Lys Ala Ser           
    450                 455                 460                           

gcc ggc ggc cac ccc atc gtg cag ctg cac ggc tac ctg gag aac gag       1440
Ala Gly Gly His Pro Ile Val Gln Leu His Gly Tyr Leu Glu Asn Glu           
465                 470                 475                 480           

ccc ctg atg ctc cag ctg ttc atc ggc acc gcc gac gac agg ctg ctg       1488
Pro Leu Met Leu Gln Leu Phe Ile Gly Thr Ala Asp Asp Arg Leu Leu           
                485                 490                 495               

agg ccc cac gcc ttc tac cag gtg cac agg atc acc ggc aag acc gtg       1536
Arg Pro His Ala Phe Tyr Gln Val His Arg Ile Thr Gly Lys Thr Val           
            500                 505                 510                   

agc acc acc agc cac gag gcc atc ctg agc aac acc aag gtg ctg gag       1584
Ser Thr Thr Ser His Glu Ala Ile Leu Ser Asn Thr Lys Val Leu Glu           
        515                 520                 525                       

atc ccc ctg ctg ccc gag aac agc atg agg gcc gtg atc gac tgc gcc       1632
Ile Pro Leu Leu Pro Glu Asn Ser Met Arg Ala Val Ile Asp Cys Ala           
    530                 535                 540                           

ggc atc ctg aag ctg agg aac agc gac atc gag ctg agg aag ggc gag       1680
Gly Ile Leu Lys Leu Arg Asn Ser Asp Ile Glu Leu Arg Lys Gly Glu           
545                 550                 555                 560           

acc gac atc ggc agg aag aac acc agg gtg agg ctg gtg ttc agg gtg       1728
Thr Asp Ile Gly Arg Lys Asn Thr Arg Val Arg Leu Val Phe Arg Val           
                565                 570                 575               

cac gtg ccc cag ccc agc ggc agg acc ctg agc ctc cag gtg gcc agc       1776
His Val Pro Gln Pro Ser Gly Arg Thr Leu Ser Leu Gln Val Ala Ser           
            580                 585                 590                   

aac ccc atc gag tgc agc cag agg agc gcc cag gag ctg ccc ctg gtg       1824
Asn Pro Ile Glu Cys Ser Gln Arg Ser Ala Gln Glu Leu Pro Leu Val           
        595                 600                 605                       

gag aag cag agc acc gac agc tac ccc gtg gtg ggc ggc aag aag atg       1872
Glu Lys Gln Ser Thr Asp Ser Tyr Pro Val Val Gly Gly Lys Lys Met           
    610                 615                 620                           

gtg ctg agc ggc cac aac ttc ctc cag gac agc aag gtg atc ttc gtg       1920
Val Leu Ser Gly His Asn Phe Leu Gln Asp Ser Lys Val Ile Phe Val           
625                 630                 635                 640           

gag aag gcc ccc gac ggc cac cac gtg tgg gag atg gag gcc aag acc       1968
Glu Lys Ala Pro Asp Gly His His Val Trp Glu Met Glu Ala Lys Thr           
                645                 650                 655               

gac agg gac ctg tgc aag ccc aac agc ctg gtg gtg gag atc ccc ccc       2016
Asp Arg Asp Leu Cys Lys Pro Asn Ser Leu Val Val Glu Ile Pro Pro           
            660                 665                 670                   

ttc agg aac cag agg atc acc agc ccc gtg cac gtg agc ttc tac gtg       2064
Phe Arg Asn Gln Arg Ile Thr Ser Pro Val His Val Ser Phe Tyr Val           
        675                 680                 685                       

tgc aac ggc aag agg aag agg agc cag tac cag agg ttc acc tac ctg       2112
Cys Asn Gly Lys Arg Lys Arg Ser Gln Tyr Gln Arg Phe Thr Tyr Leu           
    690                 695                 700                           

ccc gcc aac ggc aac gcc atc ttc ctg acc gtg agc agg gag cac gag       2160
Pro Ala Asn Gly Asn Ala Ile Phe Leu Thr Val Ser Arg Glu His Glu           
705                 710                 715                 720           

agg gtg ggc tgc ttc ttc taa                                           2181
Arg Val Gly Cys Phe Phe                                                   
                725                                                       


<210>  16
<211>  726
<212>  PRT
<213>  Homo sapiens

<400>  16

Met Glu Gln Lys Leu Ile Ser Glu Glu Asp Leu Pro Ser Thr Ser Phe 
1               5                   10                  15      


Pro Val Pro Ser Lys Phe Pro Leu Gly Pro Ala Ala Ala Val Phe Gly 
            20                  25                  30          


Arg Gly Glu Thr Leu Gly Pro Ala Pro Arg Ala Gly Gly Thr Met Lys 
        35                  40                  45              


Ser Ala Glu Glu Glu His Tyr Gly Tyr Ala Ser Ser Asn Val Ser Pro 
    50                  55                  60                  


Ala Leu Pro Leu Pro Thr Ala His Ser Thr Leu Pro Ala Pro Cys His 
65                  70                  75                  80  


Asn Leu Gln Thr Ser Thr Pro Gly Ile Ile Pro Pro Ala Asp His Pro 
                85                  90                  95      


Ser Gly Tyr Gly Ala Ala Leu Asp Gly Gly Pro Ala Gly Tyr Phe Leu 
            100                 105                 110         


Ser Ser Gly His Thr Arg Pro Asp Gly Ala Pro Ala Leu Glu Ser Pro 
        115                 120                 125             


Arg Ile Glu Ile Thr Ser Cys Leu Gly Leu Tyr His Asn Asn Asn Gln 
    130                 135                 140                 


Phe Phe His Asp Val Glu Val Glu Asp Val Leu Pro Ser Ser Lys Arg 
145                 150                 155                 160 


Ser Pro Ser Thr Ala Thr Leu Ser Leu Pro Ser Leu Glu Ala Tyr Arg 
                165                 170                 175     


Asp Pro Ser Cys Leu Ser Pro Ala Ser Ser Leu Ser Ser Arg Ser Cys 
            180                 185                 190         


Asn Ser Glu Ala Ser Ser Tyr Glu Ser Asn Tyr Ser Tyr Pro Tyr Ala 
        195                 200                 205             


Ser Pro Gln Thr Ser Pro Trp Gln Ser Pro Cys Val Ser Pro Lys Thr 
    210                 215                 220                 


Thr Asp Pro Glu Glu Gly Phe Pro Arg Gly Leu Gly Ala Cys Thr Leu 
225                 230                 235                 240 


Leu Gly Ser Pro Arg His Ser Pro Ser Thr Ser Pro Arg Ala Ser Val 
                245                 250                 255     


Thr Glu Glu Ser Trp Leu Gly Ala Arg Ser Ser Arg Pro Ala Ser Pro 
            260                 265                 270         


Cys Asn Lys Arg Lys Tyr Ser Leu Asn Gly Arg Gln Pro Pro Tyr Ser 
        275                 280                 285             


Pro His His Ser Pro Thr Pro Ser Pro His Gly Ser Pro Arg Val Ser 
    290                 295                 300                 


Val Thr Asp Asp Ser Trp Leu Gly Asn Thr Thr Gln Tyr Thr Ser Ser 
305                 310                 315                 320 


Ala Ile Val Ala Ala Ile Asn Ala Leu Thr Thr Asp Ser Ser Leu Asp 
                325                 330                 335     


Leu Gly Asp Gly Val Pro Val Lys Ser Arg Lys Thr Thr Leu Glu Gln 
            340                 345                 350         


Pro Pro Ser Val Ala Leu Lys Val Glu Pro Val Gly Glu Asp Leu Gly 
        355                 360                 365             


Ser Pro Pro Pro Pro Ala Asp Phe Ala Pro Glu Asp Tyr Ser Ser Phe 
    370                 375                 380                 


Gln His Ile Arg Lys Gly Gly Phe Cys Asp Gln Tyr Leu Ala Val Pro 
385                 390                 395                 400 


Gln His Pro Tyr Gln Trp Ala Lys Pro Lys Pro Leu Ser Pro Thr Ser 
                405                 410                 415     


Tyr Met Ser Pro Thr Leu Pro Ala Leu Asp Trp Gln Leu Pro Ser His 
            420                 425                 430         


Ser Gly Pro Tyr Glu Leu Arg Ile Glu Val Gln Pro Lys Ser His His 
        435                 440                 445             


Arg Ala His Tyr Glu Thr Glu Gly Ser Arg Gly Ala Val Lys Ala Ser 
    450                 455                 460                 


Ala Gly Gly His Pro Ile Val Gln Leu His Gly Tyr Leu Glu Asn Glu 
465                 470                 475                 480 


Pro Leu Met Leu Gln Leu Phe Ile Gly Thr Ala Asp Asp Arg Leu Leu 
                485                 490                 495     


Arg Pro His Ala Phe Tyr Gln Val His Arg Ile Thr Gly Lys Thr Val 
            500                 505                 510         


Ser Thr Thr Ser His Glu Ala Ile Leu Ser Asn Thr Lys Val Leu Glu 
        515                 520                 525             


Ile Pro Leu Leu Pro Glu Asn Ser Met Arg Ala Val Ile Asp Cys Ala 
    530                 535                 540                 


Gly Ile Leu Lys Leu Arg Asn Ser Asp Ile Glu Leu Arg Lys Gly Glu 
545                 550                 555                 560 


Thr Asp Ile Gly Arg Lys Asn Thr Arg Val Arg Leu Val Phe Arg Val 
                565                 570                 575     


His Val Pro Gln Pro Ser Gly Arg Thr Leu Ser Leu Gln Val Ala Ser 
            580                 585                 590         


Asn Pro Ile Glu Cys Ser Gln Arg Ser Ala Gln Glu Leu Pro Leu Val 
        595                 600                 605             


Glu Lys Gln Ser Thr Asp Ser Tyr Pro Val Val Gly Gly Lys Lys Met 
    610                 615                 620                 


Val Leu Ser Gly His Asn Phe Leu Gln Asp Ser Lys Val Ile Phe Val 
625                 630                 635                 640 


Glu Lys Ala Pro Asp Gly His His Val Trp Glu Met Glu Ala Lys Thr 
                645                 650                 655     


Asp Arg Asp Leu Cys Lys Pro Asn Ser Leu Val Val Glu Ile Pro Pro 
            660                 665                 670         


Phe Arg Asn Gln Arg Ile Thr Ser Pro Val His Val Ser Phe Tyr Val 
        675                 680                 685             


Cys Asn Gly Lys Arg Lys Arg Ser Gln Tyr Gln Arg Phe Thr Tyr Leu 
    690                 695                 700                 


Pro Ala Asn Gly Asn Ala Ile Phe Leu Thr Val Ser Arg Glu His Glu 
705                 710                 715                 720 


Arg Val Gly Cys Phe Phe 
                725     


<210>  17
<211>  2048
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  -


<220>
<221>  [nfat]_binding_site
<222>  (30)..(59)

<220>
<221>  [nfat]_binding_site
<222>  (60)..(89)

<220>
<221>  [nfat]_binding_site
<222>  (90)..(119)

<220>
<221>  Pmin
<222>  (152)..(183)

<220>
<221>  CDS
<222>  (219)..(2045)
<223>  fLuc

<400>  17
ctgcttaggg ttaggcgttt tgcgctgctg gaggaaaaac tgtttcatac agaaggcgtg       60

gaggaaaaac tgtttcatac agaaggcgtg gaggaaaaac tgtttcatac agaaggcgtt      120

ggctggtgcc gcaccggtaa gcagaggatc ttagagggta tataatggaa gctcgacttc      180

cagctcgagg gcaatccggt actgttggta aagccacc atg gaa gat gcc aaa aac      236
                                          Met Glu Asp Ala Lys Asn         
                                          1               5               

att aag aag ggc cca gcg cca ttc tac cca ctc gaa gac ggg acc gcc        284
Ile Lys Lys Gly Pro Ala Pro Phe Tyr Pro Leu Glu Asp Gly Thr Ala           
            10                  15                  20                    

ggc gag cag ctg cac aaa gcc atg aag cgc tac gcc ctg gtg ccc ggc        332
Gly Glu Gln Leu His Lys Ala Met Lys Arg Tyr Ala Leu Val Pro Gly           
        25                  30                  35                        

acc atc gcc ttt acc gac gca cat atc gag gtg gac att acc tac gcc        380
Thr Ile Ala Phe Thr Asp Ala His Ile Glu Val Asp Ile Thr Tyr Ala           
    40                  45                  50                            

gag tac ttc gag atg agc gtt cgg ctg gca gaa gct atg aag cgc tat        428
Glu Tyr Phe Glu Met Ser Val Arg Leu Ala Glu Ala Met Lys Arg Tyr           
55                  60                  65                  70            

ggg ctg aat aca aac cat cgg atc gtg gtg tgc agc gag aat agc ttg        476
Gly Leu Asn Thr Asn His Arg Ile Val Val Cys Ser Glu Asn Ser Leu           
                75                  80                  85                

cag ttc ttc atg ccc gtg ttg ggt gcc ctg ttc atc ggt gtg gct gtg        524
Gln Phe Phe Met Pro Val Leu Gly Ala Leu Phe Ile Gly Val Ala Val           
            90                  95                  100                   

gcc cca gct aac gac atc tac aac gag cgc gag ctg ctg aac agc atg        572
Ala Pro Ala Asn Asp Ile Tyr Asn Glu Arg Glu Leu Leu Asn Ser Met           
        105                 110                 115                       

ggc atc agc cag ccc acc gtc gta ttc gtg agc aag aaa ggg ctg caa        620
Gly Ile Ser Gln Pro Thr Val Val Phe Val Ser Lys Lys Gly Leu Gln           
    120                 125                 130                           

aag atc ctc aac gtg caa aag aag cta ccg atc ata caa aag atc atc        668
Lys Ile Leu Asn Val Gln Lys Lys Leu Pro Ile Ile Gln Lys Ile Ile           
135                 140                 145                 150           

atc atg gat agc aag acc gac tac cag ggc ttc caa agc atg tac acc        716
Ile Met Asp Ser Lys Thr Asp Tyr Gln Gly Phe Gln Ser Met Tyr Thr           
                155                 160                 165               

ttc gtg act tcc cat ttg cca ccc ggc ttc aac gag tac gac ttc gtg        764
Phe Val Thr Ser His Leu Pro Pro Gly Phe Asn Glu Tyr Asp Phe Val           
            170                 175                 180                   

ccc gag agc ttc gac cgg gac aaa acc atc gcc ctg atc atg aac agt        812
Pro Glu Ser Phe Asp Arg Asp Lys Thr Ile Ala Leu Ile Met Asn Ser           
        185                 190                 195                       

agt ggc agt acc gga ttg ccc aag ggc gta gcc cta ccg cac cgc acc        860
Ser Gly Ser Thr Gly Leu Pro Lys Gly Val Ala Leu Pro His Arg Thr           
    200                 205                 210                           

gct tgt gtc cga ttc agt cat gcc cgc gac ccc atc ttc ggc aac cag        908
Ala Cys Val Arg Phe Ser His Ala Arg Asp Pro Ile Phe Gly Asn Gln           
215                 220                 225                 230           

atc atc ccc gac acc gct atc ctc agc gtg gtg cca ttt cac cac ggc        956
Ile Ile Pro Asp Thr Ala Ile Leu Ser Val Val Pro Phe His His Gly           
                235                 240                 245               

ttc ggc atg ttc acc acg ctg ggc tac ttg atc tgc ggc ttt cgg gtc       1004
Phe Gly Met Phe Thr Thr Leu Gly Tyr Leu Ile Cys Gly Phe Arg Val           
            250                 255                 260                   

gtg ctc atg tac cgc ttc gag gag gag cta ttc ttg cgc agc ttg caa       1052
Val Leu Met Tyr Arg Phe Glu Glu Glu Leu Phe Leu Arg Ser Leu Gln           
        265                 270                 275                       

gac tat aag att caa tct gcc ctg ctg gtg ccc aca cta ttt agc ttc       1100
Asp Tyr Lys Ile Gln Ser Ala Leu Leu Val Pro Thr Leu Phe Ser Phe           
    280                 285                 290                           

ttc gct aag agc act ctc atc gac aag tac gac cta agc aac ttg cac       1148
Phe Ala Lys Ser Thr Leu Ile Asp Lys Tyr Asp Leu Ser Asn Leu His           
295                 300                 305                 310           

gag atc gcc agc ggc ggg gcg ccg ctc agc aag gag gta ggt gag gcc       1196
Glu Ile Ala Ser Gly Gly Ala Pro Leu Ser Lys Glu Val Gly Glu Ala           
                315                 320                 325               

gtg gcc aaa cgc ttc cac cta cca ggc atc cgc cag ggc tac ggc ctg       1244
Val Ala Lys Arg Phe His Leu Pro Gly Ile Arg Gln Gly Tyr Gly Leu           
            330                 335                 340                   

aca gaa aca acc agc gcc att ctg atc acc ccc gaa ggg gac gac aag       1292
Thr Glu Thr Thr Ser Ala Ile Leu Ile Thr Pro Glu Gly Asp Asp Lys           
        345                 350                 355                       

cct ggc gca gta ggc aag gtg gtg ccc ttc ttc gag gct aag gtg gtg       1340
Pro Gly Ala Val Gly Lys Val Val Pro Phe Phe Glu Ala Lys Val Val           
    360                 365                 370                           

gac ttg gac acc ggt aag aca ctg ggt gtg aac cag cgc ggc gag ctg       1388
Asp Leu Asp Thr Gly Lys Thr Leu Gly Val Asn Gln Arg Gly Glu Leu           
375                 380                 385                 390           

tgc gtc cgt ggc ccc atg atc atg agc ggc tac gtt aac aac ccc gag       1436
Cys Val Arg Gly Pro Met Ile Met Ser Gly Tyr Val Asn Asn Pro Glu           
                395                 400                 405               

gct aca aac gct ctc atc gac aag gac ggc tgg ctg cac agc ggc gac       1484
Ala Thr Asn Ala Leu Ile Asp Lys Asp Gly Trp Leu His Ser Gly Asp           
            410                 415                 420                   

atc gcc tac tgg gac gag gac gag cac ttc ttc atc gtg gac cgg ctg       1532
Ile Ala Tyr Trp Asp Glu Asp Glu His Phe Phe Ile Val Asp Arg Leu           
        425                 430                 435                       

aag agc ctg atc aaa tac aag ggc tac cag gta gcc cca gcc gaa ctg       1580
Lys Ser Leu Ile Lys Tyr Lys Gly Tyr Gln Val Ala Pro Ala Glu Leu           
    440                 445                 450                           

gag agc atc ctg ctg caa cac ccc aac atc ttc gac gcc ggg gtc gcc       1628
Glu Ser Ile Leu Leu Gln His Pro Asn Ile Phe Asp Ala Gly Val Ala           
455                 460                 465                 470           

ggc ctg ccc gac gac gat gcc ggc gag ctg ccc gcc gca gtc gtc gtg       1676
Gly Leu Pro Asp Asp Asp Ala Gly Glu Leu Pro Ala Ala Val Val Val           
                475                 480                 485               

ctg gaa cac ggt aaa acc atg acc gag aag gag atc gtg gac tat gtg       1724
Leu Glu His Gly Lys Thr Met Thr Glu Lys Glu Ile Val Asp Tyr Val           
            490                 495                 500                   

gcc agc cag gtt aca acc gcc aag aag ctg cgc ggt ggt gtt gtg ttc       1772
Ala Ser Gln Val Thr Thr Ala Lys Lys Leu Arg Gly Gly Val Val Phe           
        505                 510                 515                       

gtg gac gag gtg cct aaa gga ctg acc ggc aag ttg gac gcc cgc aag       1820
Val Asp Glu Val Pro Lys Gly Leu Thr Gly Lys Leu Asp Ala Arg Lys           
    520                 525                 530                           

atc cgc gag att ctc att aag gcc aag aag ggc ggc aag atc gcc gtg       1868
Ile Arg Glu Ile Leu Ile Lys Ala Lys Lys Gly Gly Lys Ile Ala Val           
535                 540                 545                 550           

aat tct gct tgc aag aac tgg ttc agt agc tta agc cac ttt gtg atc       1916
Asn Ser Ala Cys Lys Asn Trp Phe Ser Ser Leu Ser His Phe Val Ile           
                555                 560                 565               

cac ctt aac agc cac ggc ttc cct ccc gag gtg gag gag cag gcc gcc       1964
His Leu Asn Ser His Gly Phe Pro Pro Glu Val Glu Glu Gln Ala Ala           
            570                 575                 580                   

ggc acc ctg ccc atg agc tgc gcc cag gag agc ggc atg gat aga cac       2012
Gly Thr Leu Pro Met Ser Cys Ala Gln Glu Ser Gly Met Asp Arg His           
        585                 590                 595                       

cct gct gct tgc gcc agc gcc agg atc aac gtc taa                       2048
Pro Ala Ala Cys Ala Ser Ala Arg Ile Asn Val                               
    600                 605                                               


<210>  18
<211>  609
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  18

Met Glu Asp Ala Lys Asn Ile Lys Lys Gly Pro Ala Pro Phe Tyr Pro 
1               5                   10                  15      


Leu Glu Asp Gly Thr Ala Gly Glu Gln Leu His Lys Ala Met Lys Arg 
            20                  25                  30          


Tyr Ala Leu Val Pro Gly Thr Ile Ala Phe Thr Asp Ala His Ile Glu 
        35                  40                  45              


Val Asp Ile Thr Tyr Ala Glu Tyr Phe Glu Met Ser Val Arg Leu Ala 
    50                  55                  60                  


Glu Ala Met Lys Arg Tyr Gly Leu Asn Thr Asn His Arg Ile Val Val 
65                  70                  75                  80  


Cys Ser Glu Asn Ser Leu Gln Phe Phe Met Pro Val Leu Gly Ala Leu 
                85                  90                  95      


Phe Ile Gly Val Ala Val Ala Pro Ala Asn Asp Ile Tyr Asn Glu Arg 
            100                 105                 110         


Glu Leu Leu Asn Ser Met Gly Ile Ser Gln Pro Thr Val Val Phe Val 
        115                 120                 125             


Ser Lys Lys Gly Leu Gln Lys Ile Leu Asn Val Gln Lys Lys Leu Pro 
    130                 135                 140                 


Ile Ile Gln Lys Ile Ile Ile Met Asp Ser Lys Thr Asp Tyr Gln Gly 
145                 150                 155                 160 


Phe Gln Ser Met Tyr Thr Phe Val Thr Ser His Leu Pro Pro Gly Phe 
                165                 170                 175     


Asn Glu Tyr Asp Phe Val Pro Glu Ser Phe Asp Arg Asp Lys Thr Ile 
            180                 185                 190         


Ala Leu Ile Met Asn Ser Ser Gly Ser Thr Gly Leu Pro Lys Gly Val 
        195                 200                 205             


Ala Leu Pro His Arg Thr Ala Cys Val Arg Phe Ser His Ala Arg Asp 
    210                 215                 220                 


Pro Ile Phe Gly Asn Gln Ile Ile Pro Asp Thr Ala Ile Leu Ser Val 
225                 230                 235                 240 


Val Pro Phe His His Gly Phe Gly Met Phe Thr Thr Leu Gly Tyr Leu 
                245                 250                 255     


Ile Cys Gly Phe Arg Val Val Leu Met Tyr Arg Phe Glu Glu Glu Leu 
            260                 265                 270         


Phe Leu Arg Ser Leu Gln Asp Tyr Lys Ile Gln Ser Ala Leu Leu Val 
        275                 280                 285             


Pro Thr Leu Phe Ser Phe Phe Ala Lys Ser Thr Leu Ile Asp Lys Tyr 
    290                 295                 300                 


Asp Leu Ser Asn Leu His Glu Ile Ala Ser Gly Gly Ala Pro Leu Ser 
305                 310                 315                 320 


Lys Glu Val Gly Glu Ala Val Ala Lys Arg Phe His Leu Pro Gly Ile 
                325                 330                 335     


Arg Gln Gly Tyr Gly Leu Thr Glu Thr Thr Ser Ala Ile Leu Ile Thr 
            340                 345                 350         


Pro Glu Gly Asp Asp Lys Pro Gly Ala Val Gly Lys Val Val Pro Phe 
        355                 360                 365             


Phe Glu Ala Lys Val Val Asp Leu Asp Thr Gly Lys Thr Leu Gly Val 
    370                 375                 380                 


Asn Gln Arg Gly Glu Leu Cys Val Arg Gly Pro Met Ile Met Ser Gly 
385                 390                 395                 400 


Tyr Val Asn Asn Pro Glu Ala Thr Asn Ala Leu Ile Asp Lys Asp Gly 
                405                 410                 415     


Trp Leu His Ser Gly Asp Ile Ala Tyr Trp Asp Glu Asp Glu His Phe 
            420                 425                 430         


Phe Ile Val Asp Arg Leu Lys Ser Leu Ile Lys Tyr Lys Gly Tyr Gln 
        435                 440                 445             


Val Ala Pro Ala Glu Leu Glu Ser Ile Leu Leu Gln His Pro Asn Ile 
    450                 455                 460                 


Phe Asp Ala Gly Val Ala Gly Leu Pro Asp Asp Asp Ala Gly Glu Leu 
465                 470                 475                 480 


Pro Ala Ala Val Val Val Leu Glu His Gly Lys Thr Met Thr Glu Lys 
                485                 490                 495     


Glu Ile Val Asp Tyr Val Ala Ser Gln Val Thr Thr Ala Lys Lys Leu 
            500                 505                 510         


Arg Gly Gly Val Val Phe Val Asp Glu Val Pro Lys Gly Leu Thr Gly 
        515                 520                 525             


Lys Leu Asp Ala Arg Lys Ile Arg Glu Ile Leu Ile Lys Ala Lys Lys 
    530                 535                 540                 


Gly Gly Lys Ile Ala Val Asn Ser Ala Cys Lys Asn Trp Phe Ser Ser 
545                 550                 555                 560 


Leu Ser His Phe Val Ile His Leu Asn Ser His Gly Phe Pro Pro Glu 
                565                 570                 575     


Val Glu Glu Gln Ala Ala Gly Thr Leu Pro Met Ser Cys Ala Gln Glu 
            580                 585                 590         


Ser Gly Met Asp Arg His Pro Ala Ala Cys Ala Ser Ala Arg Ile Asn 
        595                 600                 605             


Val 
    


