                         SEQUENCE LISTING

<110>  Transgene SA
 
<120>  Immunotherapeutic product and MDSC modulator combination therapy

<130>  B373295-D37647-TG226

<150>  EP 16306333.2 
<151>  2016-10-10

<150>  EP 17305048.5 
<151>  2017-01-17

<160>  12    

<170>  PatentIn version 3.5

<210>  1
<211>  183
<212>  PRT
<213>  Hepatitis B virus

<400>  1

Met Asp Ile Asp Pro Tyr Lys Glu Phe Gly Ala Thr Val Glu Leu Leu 
1               5                   10                  15      


Ser Phe Leu Pro Ser Asp Phe Phe Pro Ser Val Arg Asp Leu Leu Asp 
            20                  25                  30          


Thr Ala Ser Ala Leu Tyr Arg Glu Ala Leu Glu Ser Pro Glu His Cys 
        35                  40                  45              


Ser Pro His His Thr Ala Leu Arg Gln Ala Ile Leu Cys Trp Gly Glu 
    50                  55                  60                  


Leu Met Thr Leu Ala Thr Trp Val Gly Gly Asn Leu Glu Asp Pro Ile 
65                  70                  75                  80  


Ser Arg Asp Leu Val Val Ser Tyr Val Asn Thr Asn Met Gly Leu Lys 
                85                  90                  95      


Phe Arg Gln Leu Leu Trp Phe His Ile Ser Cys Leu Thr Phe Gly Arg 
            100                 105                 110         


Glu Thr Val Ile Glu Tyr Leu Val Ser Phe Gly Val Trp Ile Arg Thr 
        115                 120                 125             


Pro Pro Ala Tyr Arg Pro Pro Asn Ala Pro Ile Leu Ser Thr Leu Pro 
    130                 135                 140                 


Glu Thr Thr Val Val Arg Arg Arg Gly Arg Ser Pro Arg Arg Arg Thr 
145                 150                 155                 160 


Pro Ser Pro Arg Arg Arg Arg Ser Gln Ser Pro Arg Arg Arg Arg Ser 
                165                 170                 175     


Gln Ser Arg Glu Ser Gln Cys 
            180             


<210>  2
<211>  148
<212>  PRT
<213>  artificial sequence

<220>
<223>  C-truncated Core (1-148aa)

<400>  2

Met Asp Ile Asp Pro Tyr Lys Glu Phe Gly Ala Thr Val Glu Leu Leu 
1               5                   10                  15      


Ser Phe Leu Pro Ser Asp Phe Phe Pro Ser Val Arg Asp Leu Leu Asp 
            20                  25                  30          


Thr Ala Ser Ala Leu Tyr Arg Glu Ala Leu Glu Ser Pro Glu His Cys 
        35                  40                  45              


Ser Pro His His Thr Ala Leu Arg Gln Ala Ile Leu Cys Trp Gly Glu 
    50                  55                  60                  


Leu Met Thr Leu Ala Thr Trp Val Gly Gly Asn Leu Glu Asp Pro Ile 
65                  70                  75                  80  


Ser Arg Asp Leu Val Val Ser Tyr Val Asn Thr Asn Met Gly Leu Lys 
                85                  90                  95      


Phe Arg Gln Leu Leu Trp Phe His Ile Ser Cys Leu Thr Phe Gly Arg 
            100                 105                 110         


Glu Thr Val Ile Glu Tyr Leu Val Ser Phe Gly Val Trp Ile Arg Thr 
        115                 120                 125             


Pro Pro Ala Tyr Arg Pro Pro Asn Ala Pro Ile Leu Ser Thr Leu Pro 
    130                 135                 140                 


Glu Thr Thr Val 
145             


<210>  3
<211>  832
<212>  PRT
<213>  Hepatitis B virus

<400>  3

Met Pro Leu Ser Tyr Gln His Phe Arg Arg Leu Leu Leu Leu Asp Asp 
1               5                   10                  15      


Glu Ala Gly Pro Leu Glu Glu Glu Leu Pro Arg Leu Ala Asp Glu Gly 
            20                  25                  30          


Leu Asn Arg Arg Val Ala Glu Asp Leu Asn Leu Gly Asn Leu Asn Val 
        35                  40                  45              


Ser Ile Pro Trp Thr His Lys Val Gly Asn Phe Thr Gly Leu Tyr Ser 
    50                  55                  60                  


Ser Thr Val Pro Val Phe Asn Pro His Trp Lys Thr Pro Ser Phe Pro 
65                  70                  75                  80  


Asn Ile His Leu His Gln Asp Ile Ile Lys Lys Cys Glu Gln Phe Val 
                85                  90                  95      


Gly Pro Leu Thr Val Asn Glu Lys Arg Arg Leu Gln Leu Ile Met Pro 
            100                 105                 110         


Ala Arg Phe Tyr Pro Asn Val Thr Lys Tyr Leu Pro Leu Asp Lys Gly 
        115                 120                 125             


Ile Lys Pro Tyr Tyr Pro Glu His Leu Val Asn His Tyr Phe Gln Thr 
    130                 135                 140                 


Arg His Tyr Leu His Thr Leu Trp Lys Ala Gly Ile Leu Tyr Lys Arg 
145                 150                 155                 160 


Glu Thr Thr His Ser Ala Ser Phe Cys Gly Ser Pro Tyr Ser Trp Glu 
                165                 170                 175     


Gln Lys Leu Gln His Gly Ala Glu Ser Phe His Gln Gln Ser Ser Gly 
            180                 185                 190         


Ile Leu Ser Arg Pro Pro Val Gly Ser Ser Leu Gln Ser Lys His Arg 
        195                 200                 205             


Lys Ser Arg Leu Gly Leu Gln Ser Gln Gln Gly His Leu Ala Arg Arg 
    210                 215                 220                 


Gln Gln Gly Arg Ser Trp Ser Ile Arg Ala Gly Ile His Pro Thr Ala 
225                 230                 235                 240 


Arg Arg Ser Phe Gly Val Glu Pro Ser Gly Ser Gly His Ser Thr Asn 
                245                 250                 255     


Leu Ala Ser Lys Ser Ala Ser Cys Leu Tyr Gln Ser Pro Val Arg Lys 
            260                 265                 270         


Ala Ala Tyr Pro Ala Val Ser Thr Phe Glu Lys His Ser Ser Ser Gly 
        275                 280                 285             


His Ala Val Glu Leu His Asn Leu Pro Pro Asn Ser Ala Arg Ser Gln 
    290                 295                 300                 


Ser Glu Arg Pro Val Phe Pro Cys Trp Trp Leu Gln Phe Arg Asn Ser 
305                 310                 315                 320 


Lys Pro Cys Ser Asp Tyr Cys Leu Ser His Ile Val Asn Leu Leu Glu 
                325                 330                 335     


Asp Trp Gly Pro Cys Ala Glu His Gly Glu His His Ile Arg Ile Pro 
            340                 345                 350         


Arg Thr Pro Ala Arg Val Thr Gly Gly Val Phe Leu Val Asp Lys Asn 
        355                 360                 365             


Pro His Asn Thr Ala Glu Ser Arg Leu Val Val Asp Phe Ser Gln Phe 
    370                 375                 380                 


Ser Arg Gly Asn Tyr Arg Val Ser Trp Pro Lys Phe Ala Val Pro Asn 
385                 390                 395                 400 


Leu Gln Ser Leu Thr Asn Leu Leu Ser Ser Asn Leu Ser Trp Leu Ser 
                405                 410                 415     


Leu Asp Val Ser Ala Ala Phe Tyr His Leu Pro Leu His Pro Ala Ala 
            420                 425                 430         


Met Pro His Leu Leu Val Gly Ser Ser Gly Leu Ser Arg Tyr Val Ala 
        435                 440                 445             


Arg Leu Ser Ser Asn Ser Arg Ile Phe Asn Tyr Gln His Gly Thr Met 
    450                 455                 460                 


Gln Asn Leu His Asp Ser Cys Ser Arg Asn Leu Tyr Val Ser Leu Leu 
465                 470                 475                 480 


Leu Leu Tyr Gln Thr Phe Gly Arg Lys Leu His Leu Tyr Ser His Pro 
                485                 490                 495     


Ile Ile Leu Gly Phe Arg Lys Ile Pro Met Gly Val Gly Leu Ser Pro 
            500                 505                 510         


Phe Leu Leu Ala Gln Phe Thr Ser Ala Ile Cys Ser Val Val Arg Arg 
        515                 520                 525             


Ala Phe Pro His Cys Leu Ala Phe Ser Tyr Met Asp Asp Val Val Leu 
    530                 535                 540                 


Gly Ala Lys Ser Val Gln His Leu Glu Ser Leu Phe Thr Ala Val Thr 
545                 550                 555                 560 


Asn Phe Leu Leu Ser Leu Gly Ile His Leu Asn Pro Asn Lys Thr Lys 
                565                 570                 575     


Arg Trp Gly Tyr Ser Leu His Phe Met Gly Tyr Val Ile Gly Cys Tyr 
            580                 585                 590         


Gly Ser Leu Pro Gln Asp His Ile Ile Gln Lys Ile Lys Glu Cys Phe 
        595                 600                 605             


Arg Lys Leu Pro Val Asn Arg Pro Ile Asp Trp Lys Val Cys Gln Arg 
    610                 615                 620                 


Ile Val Gly Leu Leu Gly Phe Ala Ala Pro Phe Thr Gln Cys Gly Tyr 
625                 630                 635                 640 


Pro Ala Leu Met Pro Leu Tyr Ala Cys Ile Gln Ser Lys Gln Ala Phe 
                645                 650                 655     


Thr Phe Ser Pro Thr Tyr Lys Ala Phe Leu Cys Lys Gln Tyr Leu Asn 
            660                 665                 670         


Leu Tyr Pro Val Ala Arg Gln Arg Pro Gly Leu Cys Gln Val Phe Ala 
        675                 680                 685             


Asp Ala Thr Pro Thr Gly Trp Gly Leu Val Met Gly His Gln Arg Met 
    690                 695                 700                 


Arg Gly Thr Phe Leu Ala Pro Leu Pro Ile His Thr Ala Glu Leu Leu 
705                 710                 715                 720 


Ala Ala Cys Phe Ala Arg Ser Arg Ser Gly Ala Asn Ile Leu Gly Thr 
                725                 730                 735     


Asp Asn Ser Val Val Leu Ser Arg Lys Tyr Thr Ser Phe Pro Trp Leu 
            740                 745                 750         


Leu Gly Cys Ala Ala Asn Trp Ile Leu Arg Gly Thr Ser Phe Val Tyr 
        755                 760                 765             


Val Pro Ser Ala Leu Asn Pro Thr Asp Asp Pro Ser Arg Gly Arg Leu 
    770                 775                 780                 


Gly Leu Ser Arg Pro Leu Leu Arg Leu Pro Phe Arg Pro Thr Thr Gly 
785                 790                 795                 800 


Arg Thr Ser Leu Tyr Ala Asp Ser Pro Ser Val Pro Ser His Leu Pro 
                805                 810                 815     


Asp Arg Val His Phe Ala Ser Pro Leu His Val Ala Trp Arg Pro Pro 
            820                 825                 830         


<210>  4
<211>  832
<212>  PRT
<213>  artificial sequence

<220>
<223>  mutated polymerase (YMHD + RnaseH mutation)

<400>  4

Met Pro Leu Ser Tyr Gln His Phe Arg Arg Leu Leu Leu Leu Asp Asp 
1               5                   10                  15      


Glu Ala Gly Pro Leu Glu Glu Glu Leu Pro Arg Leu Ala Asp Glu Gly 
            20                  25                  30          


Leu Asn Arg Arg Val Ala Glu Asp Leu Asn Leu Gly Asn Leu Asn Val 
        35                  40                  45              


Ser Ile Pro Trp Thr His Lys Val Gly Asn Phe Thr Gly Leu Tyr Ser 
    50                  55                  60                  


Ser Thr Val Pro Val Phe Asn Pro His Trp Lys Thr Pro Ser Phe Pro 
65                  70                  75                  80  


Asn Ile His Leu His Gln Asp Ile Ile Lys Lys Cys Glu Gln Phe Val 
                85                  90                  95      


Gly Pro Leu Thr Val Asn Glu Lys Arg Arg Leu Gln Leu Ile Met Pro 
            100                 105                 110         


Ala Arg Phe Tyr Pro Asn Val Thr Lys Tyr Leu Pro Leu Asp Lys Gly 
        115                 120                 125             


Ile Lys Pro Tyr Tyr Pro Glu His Leu Val Asn His Tyr Phe Gln Thr 
    130                 135                 140                 


Arg His Tyr Leu His Thr Leu Trp Lys Ala Gly Ile Leu Tyr Lys Arg 
145                 150                 155                 160 


Glu Thr Thr His Ser Ala Ser Phe Cys Gly Ser Pro Tyr Ser Trp Glu 
                165                 170                 175     


Gln Lys Leu Gln His Gly Ala Glu Ser Phe His Gln Gln Ser Ser Gly 
            180                 185                 190         


Ile Leu Ser Arg Pro Pro Val Gly Ser Ser Leu Gln Ser Lys His Arg 
        195                 200                 205             


Lys Ser Arg Leu Gly Leu Gln Ser Gln Gln Gly His Leu Ala Arg Arg 
    210                 215                 220                 


Gln Gln Gly Arg Ser Trp Ser Ile Arg Ala Gly Ile His Pro Thr Ala 
225                 230                 235                 240 


Arg Arg Ser Phe Gly Val Glu Pro Ser Gly Ser Gly His Ser Thr Asn 
                245                 250                 255     


Leu Ala Ser Lys Ser Ala Ser Cys Leu Tyr Gln Ser Pro Val Arg Lys 
            260                 265                 270         


Ala Ala Tyr Pro Ala Val Ser Thr Phe Glu Lys His Ser Ser Ser Gly 
        275                 280                 285             


His Ala Val Glu Leu His Asn Leu Pro Pro Asn Ser Ala Arg Ser Gln 
    290                 295                 300                 


Ser Glu Arg Pro Val Phe Pro Cys Trp Trp Leu Gln Phe Arg Asn Ser 
305                 310                 315                 320 


Lys Pro Cys Ser Asp Tyr Cys Leu Ser His Ile Val Asn Leu Leu Glu 
                325                 330                 335     


Asp Trp Gly Pro Cys Ala Glu His Gly Glu His His Ile Arg Ile Pro 
            340                 345                 350         


Arg Thr Pro Ala Arg Val Thr Gly Gly Val Phe Leu Val Asp Lys Asn 
        355                 360                 365             


Pro His Asn Thr Ala Glu Ser Arg Leu Val Val Asp Phe Ser Gln Phe 
    370                 375                 380                 


Ser Arg Gly Asn Tyr Arg Val Ser Trp Pro Lys Phe Ala Val Pro Asn 
385                 390                 395                 400 


Leu Gln Ser Leu Thr Asn Leu Leu Ser Ser Asn Leu Ser Trp Leu Ser 
                405                 410                 415     


Leu Asp Val Ser Ala Ala Phe Tyr His Leu Pro Leu His Pro Ala Ala 
            420                 425                 430         


Met Pro His Leu Leu Val Gly Ser Ser Gly Leu Ser Arg Tyr Val Ala 
        435                 440                 445             


Arg Leu Ser Ser Asn Ser Arg Ile Phe Asn Tyr Gln His Gly Thr Met 
    450                 455                 460                 


Gln Asn Leu His Asp Ser Cys Ser Arg Asn Leu Tyr Val Ser Leu Leu 
465                 470                 475                 480 


Leu Leu Tyr Gln Thr Phe Gly Arg Lys Leu His Leu Tyr Ser His Pro 
                485                 490                 495     


Ile Ile Leu Gly Phe Arg Lys Ile Pro Met Gly Val Gly Leu Ser Pro 
            500                 505                 510         


Phe Leu Leu Ala Gln Phe Thr Ser Ala Ile Cys Ser Val Val Arg Arg 
        515                 520                 525             


Ala Phe Pro His Cys Leu Ala Phe Ser Tyr Met His Asp Val Val Leu 
    530                 535                 540                 


Gly Ala Lys Ser Val Gln His Leu Glu Ser Leu Phe Thr Ala Val Thr 
545                 550                 555                 560 


Asn Phe Leu Leu Ser Leu Gly Ile His Leu Asn Pro Asn Lys Thr Lys 
                565                 570                 575     


Arg Trp Gly Tyr Ser Leu His Phe Met Gly Tyr Val Ile Gly Cys Tyr 
            580                 585                 590         


Gly Ser Leu Pro Gln Asp His Ile Ile Gln Lys Ile Lys Glu Cys Phe 
        595                 600                 605             


Arg Lys Leu Pro Val Asn Arg Pro Ile Asp Trp Lys Val Cys Gln Arg 
    610                 615                 620                 


Ile Val Gly Leu Leu Gly Phe Ala Ala Pro Phe Thr Gln Cys Gly Tyr 
625                 630                 635                 640 


Pro Ala Leu Met Pro Leu Tyr Ala Cys Ile Gln Ser Lys Gln Ala Phe 
                645                 650                 655     


Thr Phe Ser Pro Thr Tyr Lys Ala Phe Leu Cys Lys Gln Tyr Leu Asn 
            660                 665                 670         


Leu Tyr Pro Val Ala Arg Gln Arg Pro Gly Leu Cys Gln Val Phe Ala 
        675                 680                 685             


Asp Ala Thr Pro Thr Gly Trp Gly Leu Val Met Gly His Gln Arg Met 
    690                 695                 700                 


Arg Gly Thr Phe Leu Ala Pro Leu Pro Ile His Thr Ala His Leu Leu 
705                 710                 715                 720 


Ala Ala Cys Phe Ala Arg Ser Arg Ser Gly Ala Asn Ile Leu Gly Thr 
                725                 730                 735     


Asp Asn Ser Val Val Leu Ser Arg Lys Tyr Thr Ser Phe Pro Trp Leu 
            740                 745                 750         


Leu Gly Cys Ala Ala Asn Trp Ile Leu Arg Gly Thr Ser Phe Val Tyr 
        755                 760                 765             


Val Pro Ser Ala Leu Asn Pro Thr Asp Asp Pro Ser Arg Gly Arg Leu 
    770                 775                 780                 


Gly Leu Ser Arg Pro Leu Leu Arg Leu Pro Phe Arg Pro Thr Thr Gly 
785                 790                 795                 800 


Arg Thr Ser Leu Tyr Ala Asp Ser Pro Ser Val Pro Ser His Leu Pro 
                805                 810                 815     


Asp Arg Val His Phe Ala Ser Pro Leu His Val Ala Trp Arg Pro Pro 
            820                 825                 830         


<210>  5
<211>  792
<212>  PRT
<213>  artificial sequence

<220>
<223>  designed pol for TG1050 (del YMDDVVL + 4 RNase H mutations)

<400>  5

Met Pro Leu Ser Tyr Gln His Phe Arg Arg Leu Leu Leu Leu Asp Asp 
1               5                   10                  15      


Glu Ala Gly Pro Leu Glu Glu Glu Leu Pro Arg Leu Ala Asp Glu Gly 
            20                  25                  30          


Leu Asn Arg Arg Val Ala Glu Asp Leu Asn Leu Gly Asn Leu Asn Val 
        35                  40                  45              


Ser Ile Pro Trp Thr His Lys Val Gly Asn Phe Thr Gly Leu Tyr Ser 
    50                  55                  60                  


Ser Thr Val Pro Val Phe Asn Pro His Trp Lys Thr Pro Ser Phe Pro 
65                  70                  75                  80  


Asn Ile His Leu His Gln Asp Ile Ile Lys Lys Cys Glu Gln Phe Val 
                85                  90                  95      


Gly Pro Leu Thr Val Asn Glu Lys Arg Arg Leu Gln Leu Ile Met Pro 
            100                 105                 110         


Ala Arg Phe Tyr Pro Asn Val Thr Lys Tyr Leu Pro Leu Asp Lys Gly 
        115                 120                 125             


Ile Lys Pro Tyr Tyr Pro Glu His Leu Val Asn His Tyr Phe Gln Thr 
    130                 135                 140                 


Arg His Tyr Leu His Thr Leu Trp Lys Ala Gly Ile Leu Tyr Lys Arg 
145                 150                 155                 160 


Glu Thr Thr His Ser Ala Ser Phe Cys Gly Ser Pro Tyr Ser Trp Glu 
                165                 170                 175     


Gln Lys Leu Gln His Gly Ala Glu Ser Phe His Gln Gln Ser Ser Gly 
            180                 185                 190         


Ile Leu Ser Arg Pro Pro Val Gly Ser Ser Leu Gln Ser Lys His Arg 
        195                 200                 205             


Lys Ser Arg Leu Gly Leu Gln Ser Gln Gln Gly His Leu Ala Arg Arg 
    210                 215                 220                 


Gln Gln Gly Arg Ser Trp Ser Ile Arg Ala Gly Ile His Pro Thr Ala 
225                 230                 235                 240 


Arg Arg Ser Phe Gly Val Glu Pro Ser Gly Ser Gly His Ser Thr Asn 
                245                 250                 255     


Leu Ala Ser Lys Ser Ala Ser Cys Leu Tyr Gln Ser Pro Val Arg Lys 
            260                 265                 270         


Ala Ala Tyr Pro Ala Val Ser Thr Phe Glu Lys His Ser Ser Ser Gly 
        275                 280                 285             


His Ala Val Glu Leu His Asn Leu Pro Pro Asn Ser Ala Arg Ser Gln 
    290                 295                 300                 


Ser Glu Arg Pro Val Phe Pro Cys Trp Trp Leu Gln Phe Arg Asn Ser 
305                 310                 315                 320 


Lys Pro Cys Ser Asp Tyr Cys Leu Ser His Ile Val Asn Leu Leu Glu 
                325                 330                 335     


Asp Trp Gly Pro Cys Ala Glu His Gly Glu His His Ile Arg Ile Pro 
            340                 345                 350         


Arg Thr Pro Ala Arg Val Thr Gly Gly Val Phe Leu Val Asp Lys Asn 
        355                 360                 365             


Pro His Asn Thr Ala Glu Ser Arg Leu Val Val Asp Phe Ser Gln Phe 
    370                 375                 380                 


Ser Arg Gly Asn Tyr Arg Val Ser Trp Pro Lys Phe Ala Val Pro Asn 
385                 390                 395                 400 


Leu Gln Ser Leu Thr Asn Leu Leu Ser Ser Asn Leu Ser Trp Leu Ser 
                405                 410                 415     


Leu Asp Val Ser Ala Ala Phe Tyr His Leu Pro Leu His Pro Ala Ala 
            420                 425                 430         


Met Pro His Leu Leu Val Gly Ser Ser Gly Leu Ser Arg Tyr Val Ala 
        435                 440                 445             


Arg Leu Ser Ser Asn Ser Arg Ile Phe Asn Tyr Gln His Gly Thr Met 
    450                 455                 460                 


Gln Asn Leu His Asp Ser Cys Ser Arg Asn Leu Tyr Val Ser Leu Leu 
465                 470                 475                 480 


Leu Leu Tyr Gln Thr Phe Gly Arg Lys Leu His Leu Tyr Ser His Pro 
                485                 490                 495     


Ile Ile Leu Gly Phe Arg Lys Ile Pro Met Gly Val Gly Leu Ser Pro 
            500                 505                 510         


Phe Leu Leu Ala Gln Phe Thr Ser Ala Ile Cys Ser Val Val Arg Arg 
        515                 520                 525             


Ala Phe Pro His Cys Leu Ala Phe Ser Gly Ala Lys Ser Val Gln His 
    530                 535                 540                 


Leu Glu Ser Leu Phe Thr Ala Val Thr Asn Phe Leu Leu Ser Leu Gly 
545                 550                 555                 560 


Ile His Leu Asn Pro Asn Lys Thr Lys Arg Trp Gly Tyr Ser Leu His 
                565                 570                 575     


Phe Met Gly Tyr Val Ile Gly Cys Tyr Gly Ser Leu Pro Gln Asp His 
            580                 585                 590         


Ile Ile Gln Lys Ile Lys Glu Cys Phe Arg Lys Leu Pro Val Asn Arg 
        595                 600                 605             


Pro Ile Asp Trp Lys Val Cys Gln Arg Ile Val Gly Leu Leu Gly Phe 
    610                 615                 620                 


Ala Ala Pro Phe Thr Gln Cys Gly Tyr Pro Ala Leu Met Pro Leu Tyr 
625                 630                 635                 640 


Ala Cys Ile Gln Ser Lys Gln Ala Phe Thr Phe Ser Pro Thr Tyr Lys 
                645                 650                 655     


Ala Phe Leu Cys Lys Gln Tyr Leu Asn Leu Tyr Pro Val Ala Arg Gln 
            660                 665                 670         


Arg Pro Gly Leu Cys Gln Val Phe Ala His Ala Thr Pro Thr Gly Trp 
        675                 680                 685             


Gly Leu Val Met Gly His Gln Arg Met Arg Gly Thr Phe Leu Ser Arg 
    690                 695                 700                 


Lys Tyr Thr Ser Phe Pro Trp Leu Leu Gly Cys Ala Ala Asn Trp Ile 
705                 710                 715                 720 


Leu Arg Gly Thr Ser Phe Val Tyr Tyr Pro Ser Ala Leu Asn Pro Tyr 
                725                 730                 735     


His Asp Pro Ser Arg Gly Arg Leu Gly Leu Ser Arg Pro Leu Leu Arg 
            740                 745                 750         


Leu Pro Phe Arg Pro Thr Thr Gly Arg Thr Ser Leu Tyr Ala Asp Ser 
        755                 760                 765             


Pro Ser Val Pro Ser His Leu Pro Asp Arg Val His Phe Ala Ser Pro 
    770                 775                 780                 


Leu His Val Ala Trp Arg Pro Pro 
785                 790         


<210>  6
<211>  39
<212>  PRT
<213>  artificial sequence

<220>
<223>  env1 domain

<400>  6

Met Val Leu Gln Ala Gly Phe Phe Leu Leu Thr Arg Ile Leu Thr Ile 
1               5                   10                  15      


Pro Gln Ser Leu Asp Ser Trp Trp Thr Ser Leu Asn Phe Leu Gly Gly 
            20                  25                  30          


Thr Thr Val Cys Leu Gly Gln 
        35                  


<210>  7
<211>  30
<212>  PRT
<213>  artificial sequence

<220>
<223>  env2 domain

<400>  7

Trp Ala Ser Ala Arg Phe Ser Trp Leu Ser Leu Leu Val Pro Phe Val 
1               5                   10                  15      


Gln Trp Phe Val Gly Leu Ser Pro Thr Val Trp Leu Ser Val 
            20                  25                  30  


<210>  8
<211>  1007
<212>  PRT
<213>  artificial sequence

<220>
<223>  Fusion TG1050: core(1-148)-pol del YMDDVVL + del RNAse H domain) 
       + env1 + env2

<400>  8

Met Asp Ile Asp Pro Tyr Lys Glu Phe Gly Ala Thr Val Glu Leu Leu 
1               5                   10                  15      


Ser Phe Leu Pro Ser Asp Phe Phe Pro Ser Val Arg Asp Leu Leu Asp 
            20                  25                  30          


Thr Ala Ser Ala Leu Tyr Arg Glu Ala Leu Glu Ser Pro Glu His Cys 
        35                  40                  45              


Ser Pro His His Thr Ala Leu Arg Gln Ala Ile Leu Cys Trp Gly Glu 
    50                  55                  60                  


Leu Met Thr Leu Ala Thr Trp Val Gly Gly Asn Leu Glu Asp Pro Ile 
65                  70                  75                  80  


Ser Arg Asp Leu Val Val Ser Tyr Val Asn Thr Asn Met Gly Leu Lys 
                85                  90                  95      


Phe Arg Gln Leu Leu Trp Phe His Ile Ser Cys Leu Thr Phe Gly Arg 
            100                 105                 110         


Glu Thr Val Ile Glu Tyr Leu Val Ser Phe Gly Val Trp Ile Arg Thr 
        115                 120                 125             


Pro Pro Ala Tyr Arg Pro Pro Asn Ala Pro Ile Leu Ser Thr Leu Pro 
    130                 135                 140                 


Glu Thr Thr Val Pro Leu Ser Tyr Gln His Phe Arg Arg Leu Leu Leu 
145                 150                 155                 160 


Leu Asp Asp Glu Ala Gly Pro Leu Glu Glu Glu Leu Pro Arg Leu Ala 
                165                 170                 175     


Asp Glu Gly Leu Asn Arg Arg Val Ala Glu Asp Leu Asn Leu Gly Asn 
            180                 185                 190         


Leu Asn Val Ser Ile Pro Trp Thr His Lys Val Gly Asn Phe Thr Gly 
        195                 200                 205             


Leu Tyr Ser Ser Thr Val Pro Val Phe Asn Pro His Trp Lys Thr Pro 
    210                 215                 220                 


Ser Phe Pro Asn Ile His Leu His Gln Asp Ile Ile Lys Lys Cys Glu 
225                 230                 235                 240 


Gln Phe Val Gly Pro Leu Thr Val Asn Glu Lys Arg Arg Leu Gln Leu 
                245                 250                 255     


Ile Met Pro Ala Arg Phe Tyr Pro Asn Val Thr Lys Tyr Leu Pro Leu 
            260                 265                 270         


Asp Lys Gly Ile Lys Pro Tyr Tyr Pro Glu His Leu Val Asn His Tyr 
        275                 280                 285             


Phe Gln Thr Arg His Tyr Leu His Thr Leu Trp Lys Ala Gly Ile Leu 
    290                 295                 300                 


Tyr Lys Arg Glu Thr Thr His Ser Ala Ser Phe Cys Gly Ser Pro Tyr 
305                 310                 315                 320 


Ser Trp Glu Gln Lys Leu Gln His Gly Ala Glu Ser Phe His Gln Gln 
                325                 330                 335     


Ser Ser Gly Ile Leu Ser Arg Pro Pro Val Gly Ser Ser Leu Gln Ser 
            340                 345                 350         


Lys His Arg Lys Ser Arg Leu Gly Leu Gln Ser Gln Gln Gly His Leu 
        355                 360                 365             


Ala Arg Arg Gln Gln Gly Arg Ser Trp Ser Ile Arg Ala Gly Ile His 
    370                 375                 380                 


Pro Thr Ala Arg Arg Ser Phe Gly Val Glu Pro Ser Gly Ser Gly His 
385                 390                 395                 400 


Ser Thr Asn Leu Ala Ser Lys Ser Ala Ser Cys Leu Tyr Gln Ser Pro 
                405                 410                 415     


Val Arg Lys Ala Ala Tyr Pro Ala Val Ser Thr Phe Glu Lys His Ser 
            420                 425                 430         


Ser Ser Gly His Ala Val Glu Leu His Asn Leu Pro Pro Asn Ser Ala 
        435                 440                 445             


Arg Ser Gln Ser Glu Arg Pro Val Phe Pro Cys Trp Trp Leu Gln Phe 
    450                 455                 460                 


Arg Asn Ser Lys Pro Cys Ser Asp Tyr Cys Leu Ser His Ile Val Asn 
465                 470                 475                 480 


Leu Leu Glu Asp Trp Gly Pro Cys Ala Glu His Gly Glu His His Ile 
                485                 490                 495     


Arg Ile Pro Arg Thr Pro Ala Arg Val Thr Gly Gly Val Phe Leu Val 
            500                 505                 510         


Asp Lys Asn Pro His Asn Thr Ala Glu Ser Arg Leu Val Val Asp Phe 
        515                 520                 525             


Ser Gln Phe Ser Arg Gly Asn Tyr Arg Val Ser Trp Pro Lys Phe Ala 
    530                 535                 540                 


Val Pro Asn Leu Gln Ser Leu Thr Asn Leu Leu Ser Ser Asn Leu Ser 
545                 550                 555                 560 


Trp Leu Ser Leu Asp Val Ser Ala Ala Phe Tyr His Leu Pro Leu His 
                565                 570                 575     


Pro Ala Ala Met Pro His Leu Leu Val Gly Ser Ser Gly Leu Ser Arg 
            580                 585                 590         


Tyr Val Ala Arg Leu Ser Ser Asn Ser Arg Ile Phe Asn Tyr Gln His 
        595                 600                 605             


Gly Thr Met Gln Asn Leu His Asp Ser Cys Ser Arg Asn Leu Tyr Val 
    610                 615                 620                 


Ser Leu Leu Leu Leu Tyr Gln Thr Phe Gly Arg Lys Leu His Leu Tyr 
625                 630                 635                 640 


Ser His Pro Ile Ile Leu Gly Phe Arg Lys Ile Pro Met Gly Val Gly 
                645                 650                 655     


Leu Ser Pro Phe Leu Leu Ala Gln Phe Thr Ser Ala Ile Cys Ser Val 
            660                 665                 670         


Val Arg Arg Ala Phe Pro His Cys Leu Ala Phe Ser Val Leu Gln Ala 
        675                 680                 685             


Gly Phe Phe Leu Leu Thr Arg Ile Leu Thr Ile Pro Gln Ser Leu Asp 
    690                 695                 700                 


Ser Trp Trp Thr Ser Leu Asn Phe Leu Gly Gly Thr Thr Val Cys Leu 
705                 710                 715                 720 


Gly Gln Gly Ala Lys Ser Val Gln His Leu Glu Ser Leu Phe Thr Ala 
                725                 730                 735     


Val Thr Asn Phe Leu Leu Ser Leu Gly Ile His Leu Asn Pro Asn Lys 
            740                 745                 750         


Thr Lys Arg Trp Gly Tyr Ser Leu His Phe Met Gly Tyr Val Ile Gly 
        755                 760                 765             


Cys Tyr Gly Ser Leu Pro Gln Asp His Ile Ile Gln Lys Ile Lys Glu 
    770                 775                 780                 


Cys Phe Arg Lys Leu Pro Val Asn Arg Pro Ile Asp Trp Lys Val Cys 
785                 790                 795                 800 


Gln Arg Ile Val Gly Leu Leu Gly Phe Ala Ala Pro Phe Thr Gln Cys 
                805                 810                 815     


Gly Tyr Pro Ala Leu Met Pro Leu Tyr Ala Cys Ile Gln Ser Lys Gln 
            820                 825                 830         


Ala Phe Thr Phe Ser Pro Thr Tyr Lys Ala Phe Leu Cys Lys Gln Tyr 
        835                 840                 845             


Leu Asn Leu Tyr Pro Val Ala Arg Gln Arg Pro Gly Leu Cys Gln Val 
    850                 855                 860                 


Phe Ala His Ala Thr Pro Thr Gly Trp Gly Leu Val Met Gly His Gln 
865                 870                 875                 880 


Arg Met Arg Gly Thr Phe Leu Trp Ala Ser Ala Arg Phe Ser Trp Leu 
                885                 890                 895     


Ser Leu Leu Val Pro Phe Val Gln Trp Phe Val Gly Leu Ser Pro Thr 
            900                 905                 910         


Val Trp Leu Ser Val Ser Arg Lys Tyr Thr Ser Phe Pro Trp Leu Leu 
        915                 920                 925             


Gly Cys Ala Ala Asn Trp Ile Leu Arg Gly Thr Ser Phe Val Tyr Tyr 
    930                 935                 940                 


Pro Ser Ala Leu Asn Pro Tyr His Asp Pro Ser Arg Gly Arg Leu Gly 
945                 950                 955                 960 


Leu Ser Arg Pro Leu Leu Arg Leu Pro Phe Arg Pro Thr Thr Gly Arg 
                965                 970                 975     


Thr Ser Leu Tyr Ala Asp Ser Pro Ser Val Pro Ser His Leu Pro Asp 
            980                 985                 990         


Arg Val His Phe Ala Ser Pro Leu  His Val Ala Trp Arg  Pro Pro 
        995                 1000                 1005         


<210>  9
<211>  3024
<212>  DNA
<213>  artificial sequence

<220>
<223>  nt sequence eencoding fusion TG1050 (core 1-148 pol delete pol et
       RNAse H domains-env1-env2)

<400>  9
atggatatcg atccctacaa ggagttcggt gccaccgtcg aactgctgag cttcctgccc       60

agcgatttct tcccaagcgt acgtgacctt ctagatacag cctcagctct gtatcgggaa      120

gccttagagt ctcctgagca ttgttcacct caccatactg ctctcaggca agcaattctg      180

tgctggggag aactaatgac tctagctacc tgggtgggtg gtaatttgga agatccaata      240

tccagggacc tagtagtcag ttatgtcaac actaatatgg gactaaagtt ccgacaacta      300

ttgtggtttc acatttcttg tctcactttt ggaagagaaa cagttataga atatttggtg      360

tctttcggag tgtggattcg cactcctcca gcttatagac caccaaacgc accgatactg      420

agcaccctgc cagaaaccac cgtgccactg agctaccagc actttcgcag gctgttactg      480

ctggatgatg aagctggacc gctggaggag gagctgccac gtctggctga tgagggactg      540

aaccgtcgtg tggctgagga cctgaacctg ggcaacctga acgtgagcat tccttggact      600

cataaggtgg gaaactttac gggactttat tcttctactg tacctgtctt taaccctcat      660

tggaaaacac cctcttttcc taatatacat ttacaccaag acattatcaa gaaatgtgaa      720

caatttgtag gaccactcac agtcaatgag aaaagaagac tgcaattgat tatgcctgct      780

aggttttatc caaatgttac caaatatttg ccattggata agggtattaa accttattat      840

ccagaacatc tagttaatca ttacttccaa accagacatt atttacacac tctatggaag      900

gcaggtatat tatataagag agaaacaaca catagtgcct cattttgtgg gtcaccatat      960

tcttgggaac aaaagctaca gcatggagca gaatctttcc accagcaatc ctctgggatt     1020

ctttcccgac caccagttgg atccagcctt cagagcaaac accgcaaatc cagattggga     1080

cttcaatccc aacaaggaca cctggccaga cgccaacaag gtaggagctg gagcattcga     1140

gctgggattc accccaccgc acggaggtct tttggggtgg agccctcagg ctcagggcat     1200

tctacaaacc ttgccagcaa atcagcctcc tgcctctacc aatcgccagt caggaaggca     1260

gcctaccctg ctgtctccac ctttgagaaa cactcatcct caggccatgc agtggaactc     1320

cacaaccttc caccaaactc tgcaagatcc cagagtgaga ggcctgtatt tccctgctgg     1380

tggctccagt tcaggaacag taaaccctgt tccgactact gtctctccca tatcgtcaat     1440

cttctcgagg attggggacc ctgcgctgaa cacggtgagc accatattcg catcccgaga     1500

acgccagcac gcgtgaccgg tggcgtgttc ctggtggata agaacccaca taacacggct     1560

gaaagccgtc tggttgttga ctttagccag ttcagccgtg gcaattatcg cgttagctgg     1620

cctaagtttg cggtgccgaa tctgcagagc ctgacgaatc tgttaagcag caatttaagc     1680

tggctgagct tagacgttag cgcagccttc taccacctgc cactgcaccc agcagcgatg     1740

ccacacctgc tggtgggcag cagcggtctg agccgttacg tggcacgcct gagcagcaac     1800

agccgtatat ttaattatca acatggcacg atgcaaaatt tacatgatag ctgtagccgt     1860

aatctgtacg tgagcctgtt actgttatat cagacgtttg gtcgcaagct gcatttatac     1920

agccacccga ttattttagg gttccgcaag atcccgatgg gtgttggtct gtctccattc     1980

ctgttagcgc aattcaccag cgcaatctgc agcgttgtgc gcagagcgtt tccgcattgc     2040

ctggcgttta gcgtcctgca agcaggcttc ttcctgctga cccgtattct gaccattcca     2100

caaagcctgg atagctggtg gaccagcctg aacttcctgg gtggcaccac ggtttgcctg     2160

ggtcagggtg cgaaaagcgt gcaacacctg gaaagcctgt tcacggcagt gacgaacttc     2220

ctgctgagcc tgggcattca cctgaaccct aacaaaacaa agagatgggg ttactcttta     2280

catttcatgg gctatgtcat tggatgttat gggtcattgc cacaagatca catcatacaa     2340

aagatcaaag aatgttttcg aaaacttcct gttaacagac ctattgattg gaaagtctgt     2400

caacgtattg tgggtctttt gggttttgct gctcctttta cacaatgtgg ttatcctgct     2460

ttaatgcctt tgtatgcatg tattcagtcg aagcaggctt ttactttctc gccaacttac     2520

aaggcctttc tgtgtaaaca atacctgaac ctttaccctg ttgctcggca aagaccaggt     2580

ctgtgccaag tgtttgctca cgcaacccct actggctggg gattggtcat gggacatcag     2640

cgcatgcgtg gaacctttct gtgggcaagc gcacgcttta gctggctgag cctgctggtt     2700

ccgttcgtgc aatggtttgt gggtctgagc ccaaccgtgt ggctgagcgt gtccagaaaa     2760

tatacatcgt ttccatggct gctaggctgt gctgccaact ggatactgag aggcaccagc     2820

ttcgtgtatt atcccagcgc tctcaaccct taccatgatc cttctcgagg tagactgggc     2880

ctgagcagac ctctgctgag actccccttc cgacccacaa ccggaagaac aagcctgtat     2940

gccgatagcc ctagcgtccc cagccacctc cctgatagag tccattttgc cagcccactc     3000

catgtggcct ggaggcctcc ctaa                                            3024


<210>  10
<211>  10
<212>  PRT
<213>  artificial sequence

<220>
<223>  VSA Pol-specific peptide

<400>  10

Val Ser Ala Ala Phe Tyr His Leu Pro Leu 
1               5                   10  


<210>  11
<211>  15
<212>  PRT
<213>  artificial sequence

<220>
<223>  Pol-specific N13F pepide

<400>  11

Asn Leu Asn Val Ser Ile Pro Trp Thr His Lys Val Gly Asn Phe 
1               5                   10                  15  


<210>  12
<211>  9
<212>  PRT
<213>  artificial sequence

<220>
<223>  Ad-specific FAL peptide

<400>  12

Phe Ala Leu Ser Asn Ala Glu Asp Leu 
1               5                   


