                         SEQUENCE LISTING

<110>  Sanofi
 
<120>  Method of preparing peptides comprising a lipophilically modified
        lysine side chain

<130>  62509P WO / DE2016/059 WO PCT

<150>  EP 16 306 332.4
<151>  2016-10-10

<160>  6     

<170>  PatentIn version 3.5

<210>  1
<211>  39
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exendin-4 analogue


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is a D-Ser

<220>
<221>  MOD_RES
<222>  (14)..(14)
<223>  Lys is functionalized at the amino side chain group as 
       Lys((S)-4-carboxy-4-hexadecanoylamino-butyryl)

<220>
<221>  MOD_RES
<222>  (39)..(39)
<223>  Ser is modified with an NH2 group

<400>  1

His Xaa Gln Gly Thr Phe Thr Ser Asp Leu Ser Lys Gln Lys Glu Ser 
1               5                   10                  15      


Lys Ala Ala Gln Asp Phe Ile Glu Trp Leu Lys Ala Gly Gly Pro Ser 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Ser 
        35                  


<210>  2
<211>  39
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exendin-4 analogue (side product)


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is a D-Ser

<220>
<221>  MOD_RES
<222>  (39)..(39)
<223>  Ser is modified with an NH2-group

<400>  2

His Xaa Gln Gly Thr Phe Thr Ser Asp Leu Ser Lys Gln Lys Glu Ser 
1               5                   10                  15      


Lys Ala Ala Gln Asp Phe Ile Glu Trp Leu Lys Ala Gly Gly Pro Ser 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Ser 
        35                  


<210>  3
<211>  39
<212>  PRT
<213>  Heloderma suspectum


<220>
<221>  MOD_RES
<222>  (39)..(39)
<223>  Ser is modified with an NH2 group

<400>  3

His Gly Glu Gly Thr Phe Thr Ser Asp Leu Ser Lys Gln Met Glu Glu 
1               5                   10                  15      


Glu Ala Val Arg Leu Phe Ile Glu Trp Leu Lys Asn Gly Gly Pro Ser 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Ser 
        35                  


<210>  4
<211>  30
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MOD_RES
<222>  (30)..(30)
<223>  Arg is modified with an NH2 group

<400>  4

His Ala Glu Gly Thr Phe Thr Ser Asp Val Ser Ser Tyr Leu Glu Gly 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Val Lys Gly Arg 
            20                  25                  30  


<210>  5
<211>  29
<212>  PRT
<213>  Homo sapiens

<400>  5

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Ser 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  6
<211>  31
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Liraglutide


<220>
<221>  MOD_RES
<222>  (20)..(20)
<223>  Lys is functionalized at the amino side chain group as 
       Lys((S)-4-carboxy-4-hexadecanoylamino-butyryl)

<400>  6

His Ala Glu Gly Thr Phe Thr Ser Asp Val Ser Ser Tyr Leu Glu Gly 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Val Arg Gly Arg Gly 
            20                  25                  30      


