
                                SEQUENCE LISTING

<110> Nanjingjinsirui Science & Technology Biology Corp.

<120> SINGLE-DOMAIN ANTIBODIES AND VARIANTS
  THEREOF AGAINST CTLA-4

<130> 761422000340

<140> Not Yet Assigned    
<141> Concurrently Herewith            

<160> 202

<170> FastSEQ for Windows Version 4.0

<210> 1
<211> 25
<212> PRT
<213> Artificial Sequence

<220> 
<223> A34310 FR1

<400> 1
Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly
 1               5                  10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser
            20                  25  


<210> 2
<211> 25
<212> PRT
<213> Artificial Sequence

<220> 
<223> A34311 FR1

<400> 2
Gln Val Lys Leu Glu Glu Ser Gly Gly Gly Leu Val Leu Pro Gly Glu
 1               5                  10                  15      
Ser Leu Arg Leu Ser Cys Glu Ala Ser
            20                  25  


<210> 3
<211> 25
<212> PRT
<213> Artificial Sequence

<220> 
<223> A34313 FR1

<400> 3
Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly
 1               5                  10                  15      
Ser Leu Arg Leu Ser Cys Ala Thr Ser
            20                  25  


<210> 4
<211> 25
<212> PRT
<213> Artificial Sequence

<220> 
<223> A34625 FR1

<400> 4
Gln Val Lys Leu Glu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
 1               5                  10                  15      
Ser Leu Arg Leu Ser Cys Val Ala Ser
            20                  25  


<210> 5
<211> 25
<212> PRT
<213> Artificial Sequence

<220> 
<223> A36566 FR1

<400> 5
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Val Gly Asp
 1               5                  10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser
            20                  25  


<210> 6
<211> 25
<212> PRT
<213> Artificial Sequence

<220> 
<223> A36922 FR1

<400> 6
Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly
 1               5                  10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser
            20                  25  


<210> 7
<211> 25
<212> PRT
<213> Artificial Sequence

<220> 
<223> A37067 FR1

<400> 7
Ala Val Gln Leu Val Asp Ser Gly Gly Gly Leu Val Gln Ala Gly Gly
 1               5                  10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser
            20                  25  


<210> 8
<211> 25
<212> PRT
<213> Artificial Sequence

<220> 
<223> AS07014 FR1

<400> 8
Gln Val His Leu Val Glu Ser Gly Gly Gly Ser Val Gln Ala Gly Gly
 1               5                  10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser
            20                  25  


<210> 9
<211> 25
<212> PRT
<213> Artificial Sequence

<220> 
<223> AS07172 FR1

<400> 9
Gln Val Lys Leu Val Glu Ser Gly Gly Gly Ser Val Gln Ala Gly Gly
 1               5                  10                  15      
Ser Leu Arg Leu Ser Cys Ala Val Ser
            20                  25  


<210> 10
<211> 25
<212> PRT
<213> Artificial Sequence

<220> 
<223> AS07189 FR1

<400> 10
Gln Val Gln Leu Val Glu Ser Gly Gly Gly Ser Val Gln Ala Gly Gly
 1               5                  10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser
            20                  25  


<210> 11
<211> 25
<212> PRT
<213> Artificial Sequence

<220> 
<223> AS07392 FR1

<400> 11
Gln Val Lys Leu Val Glu Ser Gly Gly Gly Ser Val Gln Ala Gly Gly
 1               5                  10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser
            20                  25  


<210> 12
<211> 25
<212> PRT
<213> Artificial Sequence

<220> 
<223> AS07678 FR1

<400> 12
Gln Val His Leu Met Glu Ser Gly Gly Gly Ser Val Gln Ala Gly Gly
 1               5                  10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser
            20                  25  


<210> 13
<211> 25
<212> PRT
<213> Artificial Sequence

<220> 
<223> AS07688 FR1

<400> 13
Gln Ile Gln Leu Val Glu Ser Gly Gly Gly Ser Val Gln Ala Gly Gly
 1               5                  10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser
            20                  25  


<210> 14
<211> 25
<212> PRT
<213> Artificial Sequence

<220> 
<223> AS07712 FR1

<400> 14
Gln Ile Gln Leu Val Glu Ser Gly Gly Gly Ser Val Gln Ala Gly Gly
 1               5                  10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser
            20                  25  


<210> 15
<211> 25
<212> PRT
<213> Artificial Sequence

<220> 
<223> AS07745 FR1

<400> 15
Gln Met Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
 1               5                  10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser
            20                  25  


<210> 16
<211> 25
<212> PRT
<213> Artificial Sequence

<220> 
<223> AS07832 FR1

<400> 16
Gln Val Gln Leu Val Glu Ser Gly Gly Gly Ser Val Gln Ala Gly Gly
 1               5                  10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser
            20                  25  


<210> 17
<211> 10
<212> PRT
<213> Artificial Sequence

<220> 
<223> A34310 CDR1

<400> 17
Gly Phe Thr Phe Asp Asp Tyr Ala Ile Gly
 1               5                  10  


<210> 18
<211> 10
<212> PRT
<213> Artificial Sequence

<220> 
<223> A34311 CDR1

<400> 18
Gly Arg Thr Ile Thr Thr Ile Thr Met Gly
 1               5                  10  


<210> 19
<211> 11
<212> PRT
<213> Artificial Sequence

<220> 
<223> A34313 CDR1

<400> 19
Val Arg Thr Pro Leu Ser Asn Phe Ala Met Gly
 1               5                  10      


<210> 20
<211> 10
<212> PRT
<213> Artificial Sequence

<220> 
<223> A34625 CDR1

<400> 20
Gly Ser Ile Asp Ser Thr Tyr Thr Met Gly
 1               5                  10  


<210> 21
<211> 10
<212> PRT
<213> Artificial Sequence

<220> 
<223> A36566 CDR1

<400> 21
Gly Arg Ser Phe Glu Asn Tyr Ala Ile Gly
 1               5                  10  


<210> 22
<211> 10
<212> PRT
<213> Artificial Sequence

<220> 
<223> A36922 CDR1

<400> 22
Gly Arg Leu Ser Arg Thr Phe Thr Met Gly
 1               5                  10  


<210> 23
<211> 10
<212> PRT
<213> Artificial Sequence

<220> 
<223> A37067 CDR1

<400> 23
Gly Ser Ile Ser Ser Leu Asn Ala Met Ala
 1               5                  10  


<210> 24
<211> 10
<212> PRT
<213> Artificial Sequence

<220> 
<223> AS07014 CDR1

<400> 24
Gly Tyr Thr Tyr Ser Arg His Cys Leu Gly
 1               5                  10  


<210> 25
<211> 10
<212> PRT
<213> Artificial Sequence

<220> 
<223> AS07172 CDR1

<400> 25
Gly Asp Asp Leu Ser Asn Tyr Cys Met Gly
 1               5                  10  


<210> 26
<211> 10
<212> PRT
<213> Artificial Sequence

<220> 
<223> AS07189 CDR1

<400> 26
Gly Asp Ser Pro Ser Val Asn Tyr Met Gly
 1               5                  10  


<210> 27
<211> 10
<212> PRT
<213> Artificial Sequence

<220> 
<223> AS07392 CDR1

<400> 27
Gly Asp Ser Tyr Ser Val Lys Tyr Met Gly
 1               5                  10  


<210> 28
<211> 10
<212> PRT
<213> Artificial Sequence

<220> 
<223> AS07678 CDR1

<400> 28
Gly Tyr Thr Tyr Ser Arg Tyr Cys Leu Gly
 1               5                  10  


<210> 29
<211> 10
<212> PRT
<213> Artificial Sequence

<220> 
<223> AS07688 CDR1

<400> 29
Gly Asp Ser Tyr Ser Val Asn Tyr Met Gly
 1               5                  10  


<210> 30
<211> 10
<212> PRT
<213> Artificial Sequence

<220> 
<223> AS07712 CDR1

<400> 30
Ala Tyr Thr Asp Arg Arg Tyr Cys Met Ala
 1               5                  10  


<210> 31
<211> 10
<212> PRT
<213> Artificial Sequence

<220> 
<223> AS07745 CDR1

<400> 31
Gly Phe Thr Phe Ser Ser Tyr Tyr Met Ser
 1               5                  10  


<210> 32
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> AS07832 CDR1

<400> 32
Gly Tyr Tyr Asn Arg Tyr Cys Leu Gly
 1               5                  


<210> 33
<211> 14
<212> PRT
<213> Artificial Sequence

<220> 
<223> A34310 FR2

<400> 33
Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Gly Val Ser
 1               5                  10                  


<210> 34
<211> 14
<212> PRT
<213> Artificial Sequence

<220> 
<223> A34311 FR2

<400> 34
Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Gln Phe Val Ala
 1               5                  10                  


<210> 35
<211> 14
<212> PRT
<213> Artificial Sequence

<220> 
<223> A34313 FR2

<400> 35
Trp Phe Arg Gln Thr Pro Gly Lys Glu Arg Glu Phe Val Ala
 1               5                  10                  


<210> 36
<211> 14
<212> PRT
<213> Artificial Sequence

<220> 
<223> A34625 FR2

<400> 36
Trp Tyr Arg Gln Ala Pro Gly Lys Gln Arg Glu Leu Val Ala
 1               5                  10                  


<210> 37
<211> 14
<212> PRT
<213> Artificial Sequence

<220> 
<223> A36566 FR2

<400> 37
Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val Ala
 1               5                  10                  


<210> 38
<211> 14
<212> PRT
<213> Artificial Sequence

<220> 
<223> A36922 FR2

<400> 38
Trp Tyr Arg Gln Ala Pro Gly Lys Gln Arg Asp Leu Val Ala
 1               5                  10                  


<210> 39
<211> 14
<212> PRT
<213> Artificial Sequence

<220> 
<223> A37067 FR2

<400> 39
Trp Tyr Arg Gln Gly Pro Gly Lys Glu Arg Glu Leu Val Ala
 1               5                  10                  


<210> 40
<211> 14
<212> PRT
<213> Artificial Sequence

<220> 
<223> AS07014 FR2

<400> 40
Trp Phe Arg Gln Thr Pro Gly Lys Glu Arg Glu Ala Val Ala
 1               5                  10                  


<210> 41
<211> 14
<212> PRT
<213> Artificial Sequence

<220> 
<223> AS07172 FR2

<400> 41
Trp Val Arg Gln Ala Pro Gly Lys Glu Arg Glu Glu Val Ala
 1               5                  10                  


<210> 42
<211> 17
<212> PRT
<213> Artificial Sequence

<220> 
<223> AS07189 FR2

<400> 42
Trp Phe Arg Arg Ala Pro Glu Lys Gln Arg Glu Gln Arg Glu Glu Val
 1               5                  10                  15      
Ala
    


<210> 43
<211> 17
<212> PRT
<213> Artificial Sequence

<220> 
<223> AS07392 FR2

<400> 43
Trp Phe Arg Arg Ala Pro Gly Lys Gln Arg Asp Gln Arg Glu Glu Val
 1               5                  10                  15      
Ala
    


<210> 44
<211> 14
<212> PRT
<213> Artificial Sequence

<220> 
<223> AS07678 FR2

<400> 44
Trp Phe Arg Gln Thr Pro Gly Lys Glu Arg Glu Ala Val Ala
 1               5                  10                  


<210> 45
<211> 17
<212> PRT
<213> Artificial Sequence

<220> 
<223> AS07688 FR2

<400> 45
Trp Phe Arg Arg Ala Pro Gly Gln Gln Arg Glu Gln Arg Glu Glu Val
 1               5                  10                  15      
Ala
    


<210> 46
<211> 14
<212> PRT
<213> Artificial Sequence

<220> 
<223> AS07712 FR2

<400> 46
Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Gly Val Ala
 1               5                  10                  


<210> 47
<211> 14
<212> PRT
<213> Artificial Sequence

<220> 
<223> AS07745 FR2

<400> 47
Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ser
 1               5                  10                  


<210> 48
<211> 14
<212> PRT
<213> Artificial Sequence

<220> 
<223> AS07832 FR2

<400> 48
Trp Phe Arg Gln Thr Pro Gly Lys Glu Arg Glu Ala Val Ala
 1               5                  10                  


<210> 49
<211> 15
<212> PRT
<213> Artificial Sequence

<220> 
<223> A34310 CDR2

<400> 49
Cys Ile Ser Ser Gly Gly Thr Tyr Tyr Ala Asp Ser Val Lys Gly
 1               5                  10                  15  


<210> 50
<211> 17
<212> PRT
<213> Artificial Sequence

<220> 
<223> A34311 CDR2

<400> 50
Ser His Ser Trp Thr Asp Asn Asn Pro Tyr Tyr Ala Asp Ser Val Lys
 1               5                  10                  15      
Gly
    


<210> 51
<211> 17
<212> PRT
<213> Artificial Sequence

<220> 
<223> A34313 CDR2

<400> 51
Ala Ile Ser Arg Ser Gly Gly Ser Thr Ser Tyr Ala Asp Ser Val Lys
 1               5                  10                  15      
Gly
    


<210> 52
<211> 16
<212> PRT
<213> Artificial Sequence

<220> 
<223> A34625 CDR2

<400> 52
Ser Ile Thr Ser Ser Gly Ser Thr Asn His Ala Asp Ser Val Lys Gly
 1               5                  10                  15      


<210> 53
<211> 21
<212> PRT
<213> Artificial Sequence

<220> 
<223> A36566 CDR2

<400> 53
Thr Ile Ser Trp Ile Pro Arg Thr Ala Tyr Ser Thr Thr Tyr Tyr Ala
 1               5                  10                  15      
Asp Ser Val Lys Gly
            20      


<210> 54
<211> 16
<212> PRT
<213> Artificial Sequence

<220> 
<223> A36922 CDR2

<400> 54
Ser Ile Thr Thr Ser Gly Ser Thr Asn Tyr Ala Asp Ser Val Lys Gly
 1               5                  10                  15      


<210> 55
<211> 16
<212> PRT
<213> Artificial Sequence

<220> 
<223> A37067 CDR2

<400> 55
Ser Ile Thr Arg Gly Gly Ser Thr Ala Tyr Thr Asp Ser Val Lys Gly
 1               5                  10                  15      


<210> 56
<211> 16
<212> PRT
<213> Artificial Sequence

<220> 
<223> AS07014 CDR2

<400> 56
Thr Ile Asp Ser Asp Gly Ser Thr Ser Tyr Ala Asp Ser Val Lys Gly
 1               5                  10                  15      


<210> 57
<211> 16
<212> PRT
<213> Artificial Sequence

<220> 
<223> AS07172 CDR2

<400> 57
Thr Ile Asp Tyr Ala Phe Lys Thr Asn Tyr Ala Asp Ser Val Lys Gly
 1               5                  10                  15      


<210> 58
<211> 16
<212> PRT
<213> Artificial Sequence

<220> 
<223> AS07189 CDR2

<400> 58
Ser Ile Tyr Pro Thr Gly Gly Thr Phe Tyr Thr Asp Ser Val Lys Gly
 1               5                  10                  15      


<210> 59
<211> 16
<212> PRT
<213> Artificial Sequence

<220> 
<223> AS07392 CDR2

<400> 59
Ser Ile Tyr Pro Thr Gly Gly Thr Phe Tyr Thr Asp Ser Val Lys Gly
 1               5                  10                  15      


<210> 60
<211> 16
<212> PRT
<213> Artificial Sequence

<220> 
<223> AS07678 CDR2

<400> 60
Thr Ile Asp Ile Asp Gly Ser Thr Ser Tyr Ala Asp Ser Val Lys Gly
 1               5                  10                  15      


<210> 61
<211> 16
<212> PRT
<213> Artificial Sequence

<220> 
<223> AS07688 CDR2

<400> 61
Ser Ile Tyr Ala Thr Gly Gly Thr Phe Tyr Arg Asp Ser Val Lys Gly
 1               5                  10                  15      


<210> 62
<211> 16
<212> PRT
<213> Artificial Sequence

<220> 
<223> AS07712 CDR2

<400> 62
Thr Met Asp Thr Asp Gly Ser Thr Arg Tyr Ala Asp Ser Val Lys Gly
 1               5                  10                  15      


<210> 63
<211> 17
<212> PRT
<213> Artificial Sequence

<220> 
<223> AS07745 CDR2

<400> 63
Ser Ile Tyr Ser Asp Gly Ser Asn Thr Tyr Tyr Ala Asp Ser Val Lys
 1               5                  10                  15      
Gly
    


<210> 64
<211> 16
<212> PRT
<213> Artificial Sequence

<220> 
<223> AS07832 CDR2

<400> 64
Thr Ile Asp Thr Asp Gly Ser Thr Ser Tyr Ala Asp Ser Val Lys Gly
 1               5                  10                  15      


<210> 65
<211> 32
<212> PRT
<213> Artificial Sequence

<220> 
<223> A34310 FR3

<400> 65
Arg Phe Thr Ile Ser Ser Asp Asn Ala Lys Asn Thr Val Phe Leu Gln
 1               5                  10                  15      
Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys Gly Ala
            20                  25                  30          


<210> 66
<211> 32
<212> PRT
<213> Artificial Sequence

<220> 
<223> A34311 FR3

<400> 66
Arg Phe Ile Ile Ser Arg Asp Asn Ala Gly Asn Arg Val Tyr Leu Gln
 1               5                  10                  15      
Met His Ser Leu Glu Pro Glu Asp Thr Ala Val Tyr Tyr Cys Ala Ala
            20                  25                  30          


<210> 67
<211> 32
<212> PRT
<213> Artificial Sequence

<220> 
<223> A34313 FR3

<400> 67
Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr Leu Glu
 1               5                  10                  15      
Met Asn Ser Leu Lys Gly Glu Asp Thr Val Val Tyr Tyr Cys Ala Ala
            20                  25                  30          


<210> 68
<211> 32
<212> PRT
<213> Artificial Sequence

<220> 
<223> A34625 FR3

<400> 68
Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr Leu Gln
 1               5                  10                  15      
Met Asn Thr Leu Lys Pro Glu Asp Ala Ala Val Tyr Tyr Cys Arg Tyr
            20                  25                  30          


<210> 69
<211> 32
<212> PRT
<213> Artificial Sequence

<220> 
<223> A36566 FR3

<400> 69
Arg Phe Thr Ile Ser Gly Asp Asn Ser Lys Asn Thr Val Tyr Leu Gln
 1               5                  10                  15      
Met Thr Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys Ala Ala
            20                  25                  30          


<210> 70
<211> 32
<212> PRT
<213> Artificial Sequence

<220> 
<223> A36922 FR3

<400> 70
Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Ile Leu Gln
 1               5                  10                  15      
Met Asn Ser Leu Val Pro Glu Asp Thr Ala Val Tyr Tyr Cys Arg Phe
            20                  25                  30          


<210> 71
<211> 32
<212> PRT
<213> Artificial Sequence

<220> 
<223> A37067 FR3

<400> 71
Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr Leu Gln
 1               5                  10                  15      
Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys Arg Ala
            20                  25                  30          


<210> 72
<211> 32
<212> PRT
<213> Artificial Sequence

<220> 
<223> AS07014 FR3

<400> 72
Arg Phe Thr Ile Ser Ser Asp Asn Ala Lys Asn Thr Leu Tyr Leu Gln
 1               5                  10                  15      
Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Met Tyr Tyr Cys Ala Ile
            20                  25                  30          


<210> 73
<211> 34
<212> PRT
<213> Artificial Sequence

<220> 
<223> AS07172 FR3

<400> 73
Arg Phe Thr Ile Ser Lys Asp Asn Ala Glu Asn Ser Leu Arg Val Asn
 1               5                  10                  15      
Leu Glu Met Asn Asp Leu Lys Pro Asp Asp Thr Ala Met Tyr Tyr Cys
            20                  25                  30          
Ala Ala
        


<210> 74
<211> 32
<212> PRT
<213> Artificial Sequence

<220> 
<223> AS07189 FR3

<400> 74
Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr Leu Gln
 1               5                  10                  15      
Met Thr Ala Leu Lys Pro Glu Asp Thr Ala Met Tyr Tyr Cys Ala Ala
            20                  25                  30          


<210> 75
<211> 32
<212> PRT
<213> Artificial Sequence

<220> 
<223> AS07392 FR3

<400> 75
Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Ser Thr Leu Tyr Leu Gln
 1               5                  10                  15      
Met Thr Ala Leu Lys Pro Glu Asp Thr Ala Met Tyr Tyr Cys Ala Ala
            20                  25                  30          


<210> 76
<211> 32
<212> PRT
<213> Artificial Sequence

<220> 
<223> AS07678 FR3

<400> 76
Arg Phe Thr Ile Ser Asn Asp Asn Ala Lys Asn Thr Leu Tyr Leu Gln
 1               5                  10                  15      
Met Asn Ile Leu Lys Pro Glu Asp Thr Ala Met Tyr Tyr Cys Ala Ala
            20                  25                  30          


<210> 77
<211> 32
<212> PRT
<213> Artificial Sequence

<220> 
<223> AS07688 FR3

<400> 77
Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr Leu Gln
 1               5                  10                  15      
Met Thr Ala Leu Lys Pro Glu Asp Thr Ala Met Tyr Tyr Cys Ala Ala
            20                  25                  30          


<210> 78
<211> 32
<212> PRT
<213> Artificial Sequence

<220> 
<223> AS07712 FR3

<400> 78
Arg Phe Thr Ile Ser Thr Asp Ser Ala Lys Asn Thr Leu Tyr Leu Gln
 1               5                  10                  15      
Met Asn Ser Leu Glu Pro Glu Asp Thr Ala Met Tyr Tyr Cys Ala Val
            20                  25                  30          


<210> 79
<211> 32
<212> PRT
<213> Artificial Sequence

<220> 
<223> AS07745 FR3

<400> 79
Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr Leu Gln
 1               5                  10                  15      
Met Asn Ser Leu Lys Ser Glu Asp Thr Ala Leu Tyr Tyr Cys Ala Thr
            20                  25                  30          


<210> 80
<211> 32
<212> PRT
<213> Artificial Sequence

<220> 
<223> AS07832 FR3

<400> 80
Arg Phe Thr Ile Ser Phe Asp Asn Ala Lys Asn Thr Leu Tyr Leu Gln
 1               5                  10                  15      
Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Met Tyr Tyr Cys Ala Ala
            20                  25                  30          


<210> 81
<211> 26
<212> PRT
<213> Artificial Sequence

<220> 
<223> A34310 CDR3

<400> 81
Val Ser Ser Leu Leu Ser Val Glu Arg Phe Pro Gly Gly His Cys Gly
 1               5                  10                  15      
Pro Arg Tyr Gly Tyr Tyr Arg His Gly Tyr
            20                  25      


<210> 82
<211> 20
<212> PRT
<213> Artificial Sequence

<220> 
<223> A34311 CDR3

<400> 82
Thr Ala Arg Arg Ser Phe Val Gly Arg Gln Trp Tyr Thr Glu Ala Arg
 1               5                  10                  15      
Gln Tyr Asp Tyr
            20  


<210> 83
<211> 18
<212> PRT
<213> Artificial Sequence

<220> 
<223> A34313 CDR3

<400> 83
Lys Ile Ala Gly Met Asn Asn Ile Val Phe Ile Gly Ala Pro Gln Tyr
 1               5                  10                  15      
Asn Tyr
        


<210> 84
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> A34625 CDR3

<400> 84
Leu Ser Val Leu Ser Ala Tyr
 1               5          


<210> 85
<211> 15
<212> PRT
<213> Artificial Sequence

<220> 
<223> A36566 CDR3

<400> 85
Gly Gly Ala Thr Gly Pro Leu Ala Leu Asp Ser His Tyr Gly Tyr
 1               5                  10                  15  


<210> 86
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> A36922 CDR3

<400> 86
Leu Ser Ala Ser Thr Ala Ala
 1               5          


<210> 87
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> A37067 CDR3

<400> 87
Val Trp Gly Phe Gly Asp Tyr Gly Ser
 1               5                  


<210> 88
<211> 22
<212> PRT
<213> Artificial Sequence

<220> 
<223> AS07014 CDR3

<400> 88
Gly Pro Asn Pro Arg Tyr Cys Ser Gly Ala Pro Asn Thr Arg Gly Ala
 1               5                  10                  15      
Glu His Tyr Phe Gly Tyr
            20          


<210> 89
<211> 16
<212> PRT
<213> Artificial Sequence

<220> 
<223> AS07172 CDR3

<400> 89
Asp Trp Ser Ser Gly Gly Val Cys Phe Gly Leu Ala Asp Phe Gly Thr
 1               5                  10                  15      


<210> 90
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> AS07189 CDR3

<400> 90
Gly Lys Trp Gly Thr Asp Tyr
 1               5          


<210> 91
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> AS07392 CDR3

<400> 91
Gly Lys Trp Gly Thr Asp Tyr
 1               5          


<210> 92
<211> 22
<212> PRT
<213> Artificial Sequence

<220> 
<223> AS07678 CDR3

<400> 92
Gly Pro Asn Pro Arg Tyr Cys Ser Gly Ala Val Tyr Thr Arg Gly Ala
 1               5                  10                  15      
Glu His Tyr Phe Gly Tyr
            20          


<210> 93
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> AS07688 CDR3

<400> 93
Gly Lys Trp Gly Thr Asp Tyr
 1               5          


<210> 94
<211> 22
<212> PRT
<213> Artificial Sequence

<220> 
<223> AS07712 CDR3

<400> 94
Gly Pro Asn Pro Arg Tyr Cys Ser Gly Ala Ile Asn Thr Arg Gly Ala
 1               5                  10                  15      
Glu His Tyr Phe Gly Tyr
            20          


<210> 95
<211> 17
<212> PRT
<213> Artificial Sequence

<220> 
<223> AS07745 CDR3

<400> 95
Pro Arg Gly Ala His Gly Pro Thr Tyr Cys Ser Gly Gly Tyr Cys Tyr
 1               5                  10                  15      
Tyr
    


<210> 96
<211> 22
<212> PRT
<213> Artificial Sequence

<220> 
<223> AS07832 CDR3

<400> 96
Gly Pro Asn Pro Arg Tyr Cys Ser Gly Ala Val Asn Thr Arg Gly Ala
 1               5                  10                  15      
Glu His Tyr Phe Gly Tyr
            20          


<210> 97
<211> 399
<212> DNA
<213> Artificial Sequence

<220> 
<223> A34310 sdAb

<400> 97
caggtacagc tggtggagtc tgggggaggc ttggtgcagg ctggggggtc tctgagactc 60
tcctgtgcag cctctggatt cactttcgat gattatgcca taggctggtt ccgccaggcc 120
ccagggaagg agcgtgaggg ggtctcatgt attagtagtg gtggcacata ctatgcagac 180
tccgtgaagg gccgattcac catctccagt gacaacgcca agaacacggt gtttctgcaa 240
atgaacagcc tgaaacctga ggacacggct gtttattact gtggagcagt ttcgtcgctc 300
ttaagtgtgg agaggttccc tggaggtcat tgcggccccc gttatgggta ctaccgtcac 360
ggctactggg gccaggggac ccaggtcacc gtctcctca                        399

<210> 98
<211> 387
<212> DNA
<213> Artificial Sequence

<220> 
<223> A34311 sdAb

<400> 98
caggtaaagc tggaggagtc tgggggaggc ttggtgctgc ctggggagtc tctgagactc 60
tcctgtgaag cctctggtcg caccatcaca acgattacta tgggctggtt ccgccaggct 120
ccagggaagg agcgtcagtt tgtagcgtct catagttgga ctgataataa cccatactat 180
gcagactccg ttaagggccg attcatcatc tccagagaca acgccgggaa cagggtatat 240
ctgcagatgc atagcctgga acctgaggac acggccgttt attactgcgc agcaaccgct 300
agaagatcat tcgtgggtag acagtggtac actgaagcac gccagtatga ctactggggc 360
caggggaccc aggtcaccgt ctcctca                                     387

<210> 99
<211> 384
<212> DNA
<213> Artificial Sequence

<220> 
<223> A34313 sdAb

<400> 99
caggtacagc tggtggagtc tgggggagga ttggtgcagg ctgggggctc tctgagactc 60
tcctgtgcaa cctctgtacg cacccccctc agtaactttg ccatgggctg gttccgccag 120
actccaggga aagagcgtga gtttgtagca gcaattagca ggagtggtgg aagcacatcg 180
tatgcagact ccgtgaaggg ccgattcacc atctccaggg acaacgccaa gaacacggtg 240
tatctcgaaa tgaacagcct gaaaggcgag gacacggtcg tttattactg tgcagccaaa 300
atagcgggga tgaataatat tgtctttatc ggcgcgcccc agtataacta ctggggccag 360
gggacccagg tcaccgtctc ctca                                        384

<210> 100
<211> 345
<212> DNA
<213> Artificial Sequence

<220> 
<223> A34625 sdAb

<400> 100
caggtaaagc tggaggagtc tgggggaggc ttggtgcagc ctggggggtc tctgagactc 60
tcctgtgtag cgtctggaag catcgacagc acctatacca tgggctggta ccgccaggct 120
ccagggaaac agcgcgagtt ggtcgcttct attactagtt ctggtagcac aaaccatgca 180
gactccgtga agggccgatt cacaatctcc agagacaacg ccaagaacac ggtgtatctt 240
caaatgaaca ccctgaaacc cgaggacgcg gccgtctatt actgtagata cctaagtgtg 300
cttagtgcct actggggcca ggggacccag gtcaccgtct cctca                 345

<210> 101
<211> 384
<212> DNA
<213> Artificial Sequence

<220> 
<223> A36566 sdAb

<400> 101
gaggtgcagc tggtggagtc tgggggagga ttggtgcagg ttggggactc tctgagactc 60
tcctgtgcag cctctggacg ctcgttcgag aactatgcca taggctggtt ccgccaggct 120
ccaggcaagg agcgtgagtt tgtagcaaca atttcgtgga ttcctcgtac cgcatactct 180
accacatact atgcagactc cgtgaagggc agattcacca tctctggaga caacagcaag 240
aacacggtgt atctgcaaat gacgagcctg aaacctgagg acacggccgt ttattactgt 300
gcagcaggcg gggcgacagg accgttggcg ttggactccc actatgggta ctggggccag 360
gggacccagg tcaccgtctc ctca                                        384

<210> 102
<211> 345
<212> DNA
<213> Artificial Sequence

<220> 
<223> A36922 sdAb

<400> 102
caggtacagc tggtggagtc tgggggaggc ttggtgcagg ctggggggtc gctgagactc 60
tcctgtgcag cctctggtcg cctcagtagg acgtttacca tgggctggta ccgccaggct 120
ccagggaagc agcgcgactt ggtcgcgtct attactacaa gtggtagcac gaactatgca 180
gactccgtga agggccgatt caccatctcc agagacaacg ccaaaaacac ggtgattctg 240
caaatgaaca gcctggtacc tgaggacaca gccgtctatt actgccgttt tcttagcgca 300
agtactgcag cctggggcca ggggacccag gtcaccatct ccacg                 345

<210> 103
<211> 351
<212> DNA
<213> Artificial Sequence

<220> 
<223> A37067 sdAb

<400> 103
gccgtgcagc tggtggattc tgggggaggc ttggtgcagg ctggggggtc gctgagactc 60
tcctgtgcag cctctggaag catcagcagt ctcaacgcca tggcatggta ccgccagggt 120
ccagggaagg agcgcgagct ggtcgcaagt attactaggg gtggtagtac agcctataca 180
gactccgtga agggccgatt caccatctcc agagacaacg ccaagaacac ggtgtatctg 240
caaatgaaca gcctgaaacc tgaggacaca gccgtctatt actgtagagc ggtttggggt 300
tttggggatt atggttcctg gggccagggg acccaggtca ccgtctcttc g          351

<210> 104
<211> 390
<212> DNA
<213> Artificial Sequence

<220> 
<223> AS07014 sdAb

<400> 104
caggtgcacc tggtggagtc tgggggaggc tcggtgcagg ctggagggtc tctgagactc 60
tcctgtgcag cctctggata cacctacagt agacactgcc tgggctggtt ccgccagact 120
ccagggaagg agcgcgaggc ggtcgcgact attgatagtg atggtagcac aagctacgca 180
gactccgtga agggccgatt caccatctcc agtgacaacg ccaagaacac tctatatctg 240
caaatgaaca gcctgaaacc tgaggacact gccatgtact actgtgcgat agggccgaac 300
ccgcgatatt gtagtggcgc gcccaacact cggggcgccg aacactactt tggttactgg 360
gcccagggga cccaggtcac cgtctcctca                                  390

<210> 105
<211> 378
<212> DNA
<213> Artificial Sequence

<220> 
<223> AS07172 sdAb

<400> 105
caggtgaagt tagtggagtc tgggggaggc tcggtgcagg ctggagggtc tctaagactt 60
tcctgtgcag tgtctggaga cgatttgagt aactactgca tgggctgggt ccgccaggct 120
ccagggaagg agcgcgaaga ggtcgcaact attgattatg cctttaagac aaattacgca 180
gactccgtga agggccggtt caccatctcc aaagacaacg ccgagaatag tctacgcgta 240
aatttggaaa tgaacgacct gaaacctgac gacactgcca tgtactattg tgcggcagat 300
tggagtagtg gtggtgtgtg ttttggatta gcggactttg gtacccgggg ccaggggacc 360
caggtcaccg tctcctca                                               378

<210> 106
<211> 354
<212> DNA
<213> Artificial Sequence

<220> 
<223> AS07189 sdAb

<400> 106
caggtgcagc tggtggagtc tgggggaggc tcggtgcagg ctggagggtc tctgagactc 60
tcctgtgcag cctctggaga cagtcctagt gtgaactaca tgggctggtt ccgccgggct 120
ccagaaaaac agcgcgagca gcgcgaggag gtcgcaagta tttatcccac aggtggcacg 180
ttttacacag actccgtgaa gggccgattc accatctccc gagacaacgc caagaacact 240
ctgtatctcc aaatgaccgc cctgaaacct gaggatactg ccatgtacta ctgtgcggca 300
ggaaaatggg ggactgacta ctggggccag gggacccagg tcatcgtctc ctca       354

<210> 107
<211> 354
<212> DNA
<213> Artificial Sequence

<220> 
<223> AS07392 sdAb

<400> 107
caggtgaagt tggtggagtc tgggggaggc tcggtgcagg ctggagggtc tctgagactc 60
tcctgtgcag cctctggaga cagttatagt gtgaagtaca tgggctggtt ccgccgggct 120
ccagggaaac agcgcgacca gcgcgaggag gtcgcaagta tttatcccac aggtggcacg 180
ttttacacag actccgtgaa gggccgattc accatctccc gagacaacgc caagagcact 240
ctgtatctcc aaatgaccgc cctgaaacct gaggatactg ccatgtacta ctgtgcggca 300
ggcaaatggg ggactgacta ctggggccag gggacccagg tcaccgtctc ctca       354

<210> 108
<211> 390
<212> DNA
<213> Artificial Sequence

<220> 
<223> AS07678 sdAb

<400> 108
caggtgcacc tgatggagtc tgggggaggc tcggtgcagg ctggagggtc tctgagactc 60
tcctgtgcag cctctggata cacctacagt aggtactgcc tgggctggtt ccgccagact 120
ccagggaagg agcgcgaggc ggtcgcaact attgatattg atggtagcac aagctacgca 180
gactccgtga agggccgatt caccatctcc aatgacaacg ccaagaacac tctatatctg 240
caaatgaaca tcctgaaacc tgaggacact gccatgtact actgtgcggc agggccgaac 300
ccgcgatatt gtagtggcgc agtctacact cggggcgccg aacactactt tggttactgg 360
ggccagggga cccaggtcac cgtctcctca                                  390

<210> 109
<211> 354
<212> DNA
<213> Artificial Sequence

<220> 
<223> AS07688 sdAb

<400> 109
cagattcagc tggtggagtc tgggggaggc tcggtgcagg ctggagggtc tctgagactc 60
tcctgtgcag cctctggaga cagttatagt gtgaactaca tgggctggtt ccgccgggct 120
ccagggcaac agcgcgagca gcgcgaggag gtcgcaagta tttatgccac gggtggcacg 180
ttttacagag actccgtgaa gggccgattc accatctccc gagacaacgc caagaacact 240
ctgtatctcc aaatgaccgc cctgaaacct gaggatactg ccatgtacta ctgtgcggca 300
ggcaaatggg ggactgacta ctggggccag gggacccagg tcatcgtctc ctca       354

<210> 110
<211> 390
<212> DNA
<213> Artificial Sequence

<220> 
<223> AS07712 sdAb

<400> 110
cagattcagc tggtggagtc tgggggaggc tcggtgcagg ctggagggtc tctgagactc 60
tcctgtgcag cctctgcata caccgacaga cgctactgca tggcctggtt ccgccaggct 120
ccagggaagg agcgcgaggg ggtcgcaact atggatactg atggtagtac aaggtacgca 180
gactccgtga agggccgatt caccatctcc acagacagcg ccaagaacac tctgtatctg 240
caaatgaaca gcctggaacc tgaggacact gccatgtact actgtgcggt ggggccgaac 300
ccgcgatatt gtagtggcgc aatcaacact cggggcgccg aacactactt tggttactgg 360
ggccagggga cccaggtcac cgtctcctca                                  390

<210> 111
<211> 378
<212> DNA
<213> Artificial Sequence

<220> 
<223> AS07745 sdAb

<400> 111
cagatgcagc tggtggagtc tgggggaggc ttggtgcagc ctggggggtc tctgagactc 60
tcctgtgcag cctctggatt caccttcagt agctactaca tgagctgggt ccgccaggct 120
ccagggaagg ggctggagtg ggtgtccagt atttatagtg atggtagtaa cacatactat 180
gcagactccg tgaagggccg attcaccatc tccagagaca acgccaagaa cacggtgtat 240
ctgcaaatga acagcctgaa atctgaggac acggccctgt attactgtgc caccccaagg 300
ggtgctcacg gacctacata ttgtagtggt ggttactgct actacggggg ccaggggacc 360
caggtcaccg tctcctca                                               378

<210> 112
<211> 387
<212> DNA
<213> Artificial Sequence

<220> 
<223> AS07832 sdAb

<400> 112
caggttcagc tggtggagtc tgggggaggc tcggtgcagg ctggagggtc tctgagactc 60
tcctgtgcag cctctggata ctacaatagg tactgcctgg gctggttccg ccagactcca 120
gggaaggagc gcgaggcggt cgcaactatt gatacggatg gtagcacaag ctacgcagac 180
tccgtgaagg gccgattcac catctccttt gacaacgcca agaacactct atatctgcaa 240
atgaacagcc tgaaacctga ggacactgcc atgtactact gtgcggcagg gccgaacccg 300
cgatattgta gtggcgcggt caacactcgg ggcgccgaac actactttgg ttactgggcc 360
caggggaccc aggtcaccgt ctcctca                                     387

<210> 113
<211> 133
<212> PRT
<213> Artificial Sequence

<220> 
<223> A34310 sdAb

<400> 113
Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly
 1               5                  10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Asp Tyr
            20                  25                  30          
Ala Ile Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Gly Val
        35                  40                  45              
Ser Cys Ile Ser Ser Gly Gly Thr Tyr Tyr Ala Asp Ser Val Lys Gly
    50                  55                  60                  
Arg Phe Thr Ile Ser Ser Asp Asn Ala Lys Asn Thr Val Phe Leu Gln
65                  70                  75                  80  
Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys Gly Ala
                85                  90                  95      
Val Ser Ser Leu Leu Ser Val Glu Arg Phe Pro Gly Gly His Cys Gly
            100                 105                 110         
Pro Arg Tyr Gly Tyr Tyr Arg His Gly Tyr Trp Gly Gln Gly Thr Gln
        115                 120                 125             
Val Thr Val Ser Ser
    130             


<210> 114
<211> 129
<212> PRT
<213> Artificial Sequence

<220> 
<223> A34311 sdAb

<400> 114
Gln Val Lys Leu Glu Glu Ser Gly Gly Gly Leu Val Leu Pro Gly Glu
 1               5                  10                  15      
Ser Leu Arg Leu Ser Cys Glu Ala Ser Gly Arg Thr Ile Thr Thr Ile
            20                  25                  30          
Thr Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Gln Phe Val
        35                  40                  45              
Ala Ser His Ser Trp Thr Asp Asn Asn Pro Tyr Tyr Ala Asp Ser Val
    50                  55                  60                  
Lys Gly Arg Phe Ile Ile Ser Arg Asp Asn Ala Gly Asn Arg Val Tyr
65                  70                  75                  80  
Leu Gln Met His Ser Leu Glu Pro Glu Asp Thr Ala Val Tyr Tyr Cys
                85                  90                  95      
Ala Ala Thr Ala Arg Arg Ser Phe Val Gly Arg Gln Trp Tyr Thr Glu
            100                 105                 110         
Ala Arg Gln Tyr Asp Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser
        115                 120                 125             
Ser
    


<210> 115
<211> 128
<212> PRT
<213> Artificial Sequence

<220> 
<223> A34313 sdAb

<400> 115
Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly
 1               5                  10                  15      
Ser Leu Arg Leu Ser Cys Ala Thr Ser Val Arg Thr Pro Leu Ser Asn
            20                  25                  30          
Phe Ala Met Gly Trp Phe Arg Gln Thr Pro Gly Lys Glu Arg Glu Phe
        35                  40                  45              
Val Ala Ala Ile Ser Arg Ser Gly Gly Ser Thr Ser Tyr Ala Asp Ser
    50                  55                  60                  
Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val
65                  70                  75                  80  
Tyr Leu Glu Met Asn Ser Leu Lys Gly Glu Asp Thr Val Val Tyr Tyr
                85                  90                  95      
Cys Ala Ala Lys Ile Ala Gly Met Asn Asn Ile Val Phe Ile Gly Ala
            100                 105                 110         
Pro Gln Tyr Asn Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser
        115                 120                 125             


<210> 116
<211> 115
<212> PRT
<213> Artificial Sequence

<220> 
<223> A34625 sdAb

<400> 116
Gln Val Lys Leu Glu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
 1               5                  10                  15      
Ser Leu Arg Leu Ser Cys Val Ala Ser Gly Ser Ile Asp Ser Thr Tyr
            20                  25                  30          
Thr Met Gly Trp Tyr Arg Gln Ala Pro Gly Lys Gln Arg Glu Leu Val
        35                  40                  45              
Ala Ser Ile Thr Ser Ser Gly Ser Thr Asn His Ala Asp Ser Val Lys
    50                  55                  60                  
Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr Leu
65                  70                  75                  80  
Gln Met Asn Thr Leu Lys Pro Glu Asp Ala Ala Val Tyr Tyr Cys Arg
                85                  90                  95      
Tyr Leu Ser Val Leu Ser Ala Tyr Trp Gly Gln Gly Thr Gln Val Thr
            100                 105                 110         
Val Ser Ser
        115 


<210> 117
<211> 128
<212> PRT
<213> Artificial Sequence

<220> 
<223> A36566 sdAb

<400> 117
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Val Gly Asp
 1               5                  10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Ser Phe Glu Asn Tyr
            20                  25                  30          
Ala Ile Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val
        35                  40                  45              
Ala Thr Ile Ser Trp Ile Pro Arg Thr Ala Tyr Ser Thr Thr Tyr Tyr
    50                  55                  60                  
Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Gly Asp Asn Ser Lys
65                  70                  75                  80  
Asn Thr Val Tyr Leu Gln Met Thr Ser Leu Lys Pro Glu Asp Thr Ala
                85                  90                  95      
Val Tyr Tyr Cys Ala Ala Gly Gly Ala Thr Gly Pro Leu Ala Leu Asp
            100                 105                 110         
Ser His Tyr Gly Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser
        115                 120                 125             


<210> 118
<211> 115
<212> PRT
<213> Artificial Sequence

<220> 
<223> A36922 sdAb

<400> 118
Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly
 1               5                  10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Leu Ser Arg Thr Phe
            20                  25                  30          
Thr Met Gly Trp Tyr Arg Gln Ala Pro Gly Lys Gln Arg Asp Leu Val
        35                  40                  45              
Ala Ser Ile Thr Thr Ser Gly Ser Thr Asn Tyr Ala Asp Ser Val Lys
    50                  55                  60                  
Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Ile Leu
65                  70                  75                  80  
Gln Met Asn Ser Leu Val Pro Glu Asp Thr Ala Val Tyr Tyr Cys Arg
                85                  90                  95      
Phe Leu Ser Ala Ser Thr Ala Ala Trp Gly Gln Gly Thr Gln Val Thr
            100                 105                 110         
Ile Ser Thr
        115 


<210> 119
<211> 117
<212> PRT
<213> Artificial Sequence

<220> 
<223> A37067 sdAb

<400> 119
Ala Val Gln Leu Val Asp Ser Gly Gly Gly Leu Val Gln Ala Gly Gly
 1               5                  10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ser Ile Ser Ser Leu Asn
            20                  25                  30          
Ala Met Ala Trp Tyr Arg Gln Gly Pro Gly Lys Glu Arg Glu Leu Val
        35                  40                  45              
Ala Ser Ile Thr Arg Gly Gly Ser Thr Ala Tyr Thr Asp Ser Val Lys
    50                  55                  60                  
Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr Leu
65                  70                  75                  80  
Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys Arg
                85                  90                  95      
Ala Val Trp Gly Phe Gly Asp Tyr Gly Ser Trp Gly Gln Gly Thr Gln
            100                 105                 110         
Val Thr Val Ser Ser
        115         


<210> 120
<211> 130
<212> PRT
<213> Artificial Sequence

<220> 
<223> AS07014 sdAb

<400> 120
Gln Val His Leu Val Glu Ser Gly Gly Gly Ser Val Gln Ala Gly Gly
 1               5                  10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Tyr Thr Tyr Ser Arg His
            20                  25                  30          
Cys Leu Gly Trp Phe Arg Gln Thr Pro Gly Lys Glu Arg Glu Ala Val
        35                  40                  45              
Ala Thr Ile Asp Ser Asp Gly Ser Thr Ser Tyr Ala Asp Ser Val Lys
    50                  55                  60                  
Gly Arg Phe Thr Ile Ser Ser Asp Asn Ala Lys Asn Thr Leu Tyr Leu
65                  70                  75                  80  
Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Met Tyr Tyr Cys Ala
                85                  90                  95      
Ile Gly Pro Asn Pro Arg Tyr Cys Ser Gly Ala Pro Asn Thr Arg Gly
            100                 105                 110         
Ala Glu His Tyr Phe Gly Tyr Trp Ala Gln Gly Thr Gln Val Thr Val
        115                 120                 125             
Ser Ser
    130 


<210> 121
<211> 126
<212> PRT
<213> Artificial Sequence

<220> 
<223> AS07172 sdAb

<400> 121
Gln Val Lys Leu Val Glu Ser Gly Gly Gly Ser Val Gln Ala Gly Gly
 1               5                  10                  15      
Ser Leu Arg Leu Ser Cys Ala Val Ser Gly Asp Asp Leu Ser Asn Tyr
            20                  25                  30          
Cys Met Gly Trp Val Arg Gln Ala Pro Gly Lys Glu Arg Glu Glu Val
        35                  40                  45              
Ala Thr Ile Asp Tyr Ala Phe Lys Thr Asn Tyr Ala Asp Ser Val Lys
    50                  55                  60                  
Gly Arg Phe Thr Ile Ser Lys Asp Asn Ala Glu Asn Ser Leu Arg Val
65                  70                  75                  80  
Asn Leu Glu Met Asn Asp Leu Lys Pro Asp Asp Thr Ala Met Tyr Tyr
                85                  90                  95      
Cys Ala Ala Asp Trp Ser Ser Gly Gly Val Cys Phe Gly Leu Ala Asp
            100                 105                 110         
Phe Gly Thr Arg Gly Gln Gly Thr Gln Val Thr Val Ser Ser
        115                 120                 125     


<210> 122
<211> 118
<212> PRT
<213> Artificial Sequence

<220> 
<223> AS07189 sdAb

<400> 122
Gln Val Gln Leu Val Glu Ser Gly Gly Gly Ser Val Gln Ala Gly Gly
 1               5                  10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Asp Ser Pro Ser Val Asn
            20                  25                  30          
Tyr Met Gly Trp Phe Arg Arg Ala Pro Glu Lys Gln Arg Glu Gln Arg
        35                  40                  45              
Glu Glu Val Ala Ser Ile Tyr Pro Thr Gly Gly Thr Phe Tyr Thr Asp
    50                  55                  60                  
Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr
65                  70                  75                  80  
Leu Tyr Leu Gln Met Thr Ala Leu Lys Pro Glu Asp Thr Ala Met Tyr
                85                  90                  95      
Tyr Cys Ala Ala Gly Lys Trp Gly Thr Asp Tyr Trp Gly Gln Gly Thr
            100                 105                 110         
Gln Val Ile Val Ser Ser
        115             


<210> 123
<211> 118
<212> PRT
<213> Artificial Sequence

<220> 
<223> AS07392 sdAb

<400> 123
Gln Val Lys Leu Val Glu Ser Gly Gly Gly Ser Val Gln Ala Gly Gly
 1               5                  10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Asp Ser Tyr Ser Val Lys
            20                  25                  30          
Tyr Met Gly Trp Phe Arg Arg Ala Pro Gly Lys Gln Arg Asp Gln Arg
        35                  40                  45              
Glu Glu Val Ala Ser Ile Tyr Pro Thr Gly Gly Thr Phe Tyr Thr Asp
    50                  55                  60                  
Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Ser Thr
65                  70                  75                  80  
Leu Tyr Leu Gln Met Thr Ala Leu Lys Pro Glu Asp Thr Ala Met Tyr
                85                  90                  95      
Tyr Cys Ala Ala Gly Lys Trp Gly Thr Asp Tyr Trp Gly Gln Gly Thr
            100                 105                 110         
Gln Val Thr Val Ser Ser
        115             


<210> 124
<211> 130
<212> PRT
<213> Artificial Sequence

<220> 
<223> AS07678 sdAb

<400> 124
Gln Val His Leu Met Glu Ser Gly Gly Gly Ser Val Gln Ala Gly Gly
 1               5                  10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Tyr Thr Tyr Ser Arg Tyr
            20                  25                  30          
Cys Leu Gly Trp Phe Arg Gln Thr Pro Gly Lys Glu Arg Glu Ala Val
        35                  40                  45              
Ala Thr Ile Asp Ile Asp Gly Ser Thr Ser Tyr Ala Asp Ser Val Lys
    50                  55                  60                  
Gly Arg Phe Thr Ile Ser Asn Asp Asn Ala Lys Asn Thr Leu Tyr Leu
65                  70                  75                  80  
Gln Met Asn Ile Leu Lys Pro Glu Asp Thr Ala Met Tyr Tyr Cys Ala
                85                  90                  95      
Ala Gly Pro Asn Pro Arg Tyr Cys Ser Gly Ala Val Tyr Thr Arg Gly
            100                 105                 110         
Ala Glu His Tyr Phe Gly Tyr Trp Gly Gln Gly Thr Gln Val Thr Val
        115                 120                 125             
Ser Ser
    130 


<210> 125
<211> 118
<212> PRT
<213> Artificial Sequence

<220> 
<223> AS07688 sdAb

<400> 125
Gln Ile Gln Leu Val Glu Ser Gly Gly Gly Ser Val Gln Ala Gly Gly
 1               5                  10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Asp Ser Tyr Ser Val Asn
            20                  25                  30          
Tyr Met Gly Trp Phe Arg Arg Ala Pro Gly Gln Gln Arg Glu Gln Arg
        35                  40                  45              
Glu Glu Val Ala Ser Ile Tyr Ala Thr Gly Gly Thr Phe Tyr Arg Asp
    50                  55                  60                  
Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr
65                  70                  75                  80  
Leu Tyr Leu Gln Met Thr Ala Leu Lys Pro Glu Asp Thr Ala Met Tyr
                85                  90                  95      
Tyr Cys Ala Ala Gly Lys Trp Gly Thr Asp Tyr Trp Gly Gln Gly Thr
            100                 105                 110         
Gln Val Ile Val Ser Ser
        115             


<210> 126
<211> 130
<212> PRT
<213> Artificial Sequence

<220> 
<223> AS07712 sdAb

<400> 126
Gln Ile Gln Leu Val Glu Ser Gly Gly Gly Ser Val Gln Ala Gly Gly
 1               5                  10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Ala Tyr Thr Asp Arg Arg Tyr
            20                  25                  30          
Cys Met Ala Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Gly Val
        35                  40                  45              
Ala Thr Met Asp Thr Asp Gly Ser Thr Arg Tyr Ala Asp Ser Val Lys
    50                  55                  60                  
Gly Arg Phe Thr Ile Ser Thr Asp Ser Ala Lys Asn Thr Leu Tyr Leu
65                  70                  75                  80  
Gln Met Asn Ser Leu Glu Pro Glu Asp Thr Ala Met Tyr Tyr Cys Ala
                85                  90                  95      
Val Gly Pro Asn Pro Arg Tyr Cys Ser Gly Ala Ile Asn Thr Arg Gly
            100                 105                 110         
Ala Glu His Tyr Phe Gly Tyr Trp Gly Gln Gly Thr Gln Val Thr Val
        115                 120                 125             
Ser Ser
    130 


<210> 127
<211> 126
<212> PRT
<213> Artificial Sequence

<220> 
<223> AS07745 sdAb

<400> 127
Gln Met Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
 1               5                  10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr
            20                  25                  30          
Tyr Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
        35                  40                  45              
Ser Ser Ile Tyr Ser Asp Gly Ser Asn Thr Tyr Tyr Ala Asp Ser Val
    50                  55                  60                  
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Lys Ser Glu Asp Thr Ala Leu Tyr Tyr Cys
                85                  90                  95      
Ala Thr Pro Arg Gly Ala His Gly Pro Thr Tyr Cys Ser Gly Gly Tyr
            100                 105                 110         
Cys Tyr Tyr Gly Gly Gln Gly Thr Gln Val Thr Val Ser Ser
        115                 120                 125     


<210> 128
<211> 129
<212> PRT
<213> Artificial Sequence

<220> 
<223> AS07832 sdAb

<400> 128
Gln Val Gln Leu Val Glu Ser Gly Gly Gly Ser Val Gln Ala Gly Gly
 1               5                  10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Tyr Tyr Asn Arg Tyr Cys
            20                  25                  30          
Leu Gly Trp Phe Arg Gln Thr Pro Gly Lys Glu Arg Glu Ala Val Ala
        35                  40                  45              
Thr Ile Asp Thr Asp Gly Ser Thr Ser Tyr Ala Asp Ser Val Lys Gly
    50                  55                  60                  
Arg Phe Thr Ile Ser Phe Asp Asn Ala Lys Asn Thr Leu Tyr Leu Gln
65                  70                  75                  80  
Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Met Tyr Tyr Cys Ala Ala
                85                  90                  95      
Gly Pro Asn Pro Arg Tyr Cys Ser Gly Ala Val Asn Thr Arg Gly Ala
            100                 105                 110         
Glu His Tyr Phe Gly Tyr Trp Ala Gln Gly Thr Gln Val Thr Val Ser
        115                 120                 125             
Ser
    


<210> 129
<211> 129
<212> PRT
<213> Artificial Sequence

<220> 
<223> AS02640 humanized sdAb

<400> 129
Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg
 1               5                  10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Thr Ile Thr Thr Ile
            20                  25                  30          
Thr Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Gly Leu Glu Phe Val
        35                  40                  45              
Ala Ser His Ser Trp Thr Asp Asn Asn Pro Tyr Tyr Ala Asp Ser Val
    50                  55                  60                  
Lys Gly Arg Phe Ile Ile Ser Arg Asp Asn Ser Lys Asn Arg Leu Tyr
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
                85                  90                  95      
Ala Ala Thr Ala Arg Arg Ser Phe Val Gly Arg Gln Trp Tyr Thr Glu
            100                 105                 110         
Ala Arg Gln Tyr Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser
        115                 120                 125             
Ser
    


<210> 130
<211> 361
<212> PRT
<213> Artificial Sequence

<220> 
<223> A34311 HCAb monomeric form

<400> 130
Gln Val Lys Leu Glu Glu Ser Gly Gly Gly Leu Val Leu Pro Gly Glu
 1               5                  10                  15      
Ser Leu Arg Leu Ser Cys Glu Ala Ser Gly Arg Thr Ile Thr Thr Ile
            20                  25                  30          
Thr Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Gln Phe Val
        35                  40                  45              
Ala Ser His Ser Trp Thr Asp Asn Asn Pro Tyr Tyr Ala Asp Ser Val
    50                  55                  60                  
Lys Gly Arg Phe Ile Ile Ser Arg Asp Asn Ala Gly Asn Arg Val Tyr
65                  70                  75                  80  
Leu Gln Met His Ser Leu Glu Pro Glu Asp Thr Ala Val Tyr Tyr Cys
                85                  90                  95      
Ala Ala Thr Ala Arg Arg Ser Phe Val Gly Arg Gln Trp Tyr Thr Glu
            100                 105                 110         
Ala Arg Gln Tyr Asp Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser
        115                 120                 125             
Ser Glu Pro Lys Ser Ser Asp Lys Thr His Thr Ser Pro Pro Ser Pro
    130                 135                 140                 
Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys
145                 150                 155                 160 
Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val
                165                 170                 175     
Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr
            180                 185                 190         
Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu
        195                 200                 205             
Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His
    210                 215                 220                 
Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys
225                 230                 235                 240 
Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln
                245                 250                 255     
Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu
            260                 265                 270         
Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro
        275                 280                 285             
Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn
    290                 295                 300                 
Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu
305                 310                 315                 320 
Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val
                325                 330                 335     
Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln
            340                 345                 350         
Lys Ser Leu Ser Leu Ser Pro Gly Lys
        355                 360     


<210> 131
<211> 361
<212> PRT
<213> Artificial Sequence

<220> 
<223> A34311 HCAb dimeric form

<400> 131
Gln Val Lys Leu Glu Glu Ser Gly Gly Gly Leu Val Leu Pro Gly Glu
 1               5                  10                  15      
Ser Leu Arg Leu Ser Cys Glu Ala Ser Gly Arg Thr Ile Thr Thr Ile
            20                  25                  30          
Thr Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Gln Phe Val
        35                  40                  45              
Ala Ser His Ser Trp Thr Asp Asn Asn Pro Tyr Tyr Ala Asp Ser Val
    50                  55                  60                  
Lys Gly Arg Phe Ile Ile Ser Arg Asp Asn Ala Gly Asn Arg Val Tyr
65                  70                  75                  80  
Leu Gln Met His Ser Leu Glu Pro Glu Asp Thr Ala Val Tyr Tyr Cys
                85                  90                  95      
Ala Ala Thr Ala Arg Arg Ser Phe Val Gly Arg Gln Trp Tyr Thr Glu
            100                 105                 110         
Ala Arg Gln Tyr Asp Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser
        115                 120                 125             
Ser Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro
    130                 135                 140                 
Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys
145                 150                 155                 160 
Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val
                165                 170                 175     
Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr
            180                 185                 190         
Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu
        195                 200                 205             
Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His
    210                 215                 220                 
Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys
225                 230                 235                 240 
Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln
                245                 250                 255     
Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu
            260                 265                 270         
Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro
        275                 280                 285             
Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn
    290                 295                 300                 
Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu
305                 310                 315                 320 
Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val
                325                 330                 335     
Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln
            340                 345                 350         
Lys Ser Leu Ser Leu Ser Pro Gly Lys
        355                 360     


<210> 132
<211> 361
<212> PRT
<213> Artificial Sequence

<220> 
<223> AS02640 HCAb monomeric form

<400> 132
Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg
 1               5                  10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Thr Ile Thr Thr Ile
            20                  25                  30          
Thr Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Gly Leu Glu Phe Val
        35                  40                  45              
Ala Ser His Ser Trp Thr Asp Asn Asn Pro Tyr Tyr Ala Asp Ser Val
    50                  55                  60                  
Lys Gly Arg Phe Ile Ile Ser Arg Asp Asn Ser Lys Asn Arg Leu Tyr
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
                85                  90                  95      
Ala Ala Thr Ala Arg Arg Ser Phe Val Gly Arg Gln Trp Tyr Thr Glu
            100                 105                 110         
Ala Arg Gln Tyr Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser
        115                 120                 125             
Ser Glu Pro Lys Ser Ser Asp Lys Thr His Thr Ser Pro Pro Ser Pro
    130                 135                 140                 
Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys
145                 150                 155                 160 
Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val
                165                 170                 175     
Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr
            180                 185                 190         
Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu
        195                 200                 205             
Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His
    210                 215                 220                 
Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys
225                 230                 235                 240 
Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln
                245                 250                 255     
Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu
            260                 265                 270         
Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro
        275                 280                 285             
Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn
    290                 295                 300                 
Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu
305                 310                 315                 320 
Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val
                325                 330                 335     
Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln
            340                 345                 350         
Lys Ser Leu Ser Leu Ser Pro Gly Lys
        355                 360     


<210> 133
<211> 361
<212> PRT
<213> Artificial Sequence

<220> 
<223> AS02640 HCAb dimeric form

<400> 133
Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg
 1               5                  10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Thr Ile Thr Thr Ile
            20                  25                  30          
Thr Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Gly Leu Glu Phe Val
        35                  40                  45              
Ala Ser His Ser Trp Thr Asp Asn Asn Pro Tyr Tyr Ala Asp Ser Val
    50                  55                  60                  
Lys Gly Arg Phe Ile Ile Ser Arg Asp Asn Ser Lys Asn Arg Leu Tyr
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
                85                  90                  95      
Ala Ala Thr Ala Arg Arg Ser Phe Val Gly Arg Gln Trp Tyr Thr Glu
            100                 105                 110         
Ala Arg Gln Tyr Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser
        115                 120                 125             
Ser Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro
    130                 135                 140                 
Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys
145                 150                 155                 160 
Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val
                165                 170                 175     
Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr
            180                 185                 190         
Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu
        195                 200                 205             
Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His
    210                 215                 220                 
Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys
225                 230                 235                 240 
Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln
                245                 250                 255     
Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu
            260                 265                 270         
Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro
        275                 280                 285             
Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn
    290                 295                 300                 
Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu
305                 310                 315                 320 
Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val
                325                 330                 335     
Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln
            340                 345                 350         
Lys Ser Leu Ser Leu Ser Pro Gly Lys
        355                 360     


<210> 134
<211> 585
<212> PRT
<213> Artificial Sequence

<220> 
<223> BCP-K311 (Keytruda-9GS-A34311) heavy chain fusion sequence

<400> 134
Gln Val Gln Leu Val Gln Ser Gly Val Glu Val Lys Lys Pro Gly Ala
 1               5                  10                  15      
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asn Tyr
            20                  25                  30          
Tyr Met Tyr Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met
        35                  40                  45              
Gly Gly Ile Asn Pro Ser Asn Gly Gly Thr Asn Phe Asn Glu Lys Phe
    50                  55                  60                  
Lys Asn Arg Val Thr Leu Thr Thr Asp Ser Ser Thr Thr Thr Ala Tyr
65                  70                  75                  80  
Met Glu Leu Lys Ser Leu Gln Phe Asp Asp Thr Ala Val Tyr Tyr Cys
                85                  90                  95      
Ala Arg Arg Asp Tyr Arg Phe Asp Met Gly Phe Asp Tyr Trp Gly Gln
            100                 105                 110         
Gly Thr Thr Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val
        115                 120                 125             
Phe Pro Leu Ala Pro Cys Ser Arg Ser Thr Ser Glu Ser Thr Ala Ala
    130                 135                 140                 
Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser
145                 150                 155                 160 
Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val
                165                 170                 175     
Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro
            180                 185                 190         
Ser Ser Ser Leu Gly Thr Lys Thr Tyr Thr Cys Asn Val Asp His Lys
        195                 200                 205             
Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu Ser Lys Tyr Gly Pro
    210                 215                 220                 
Pro Cys Pro Pro Cys Pro Ala Pro Glu Phe Leu Gly Gly Pro Ser Val
225                 230                 235                 240 
Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr
                245                 250                 255     
Pro Glu Val Thr Cys Val Val Val Asp Val Ser Gln Glu Asp Pro Glu
            260                 265                 270         
Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys
        275                 280                 285             
Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser
    290                 295                 300                 
Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys
305                 310                 315                 320 
Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile
                325                 330                 335     
Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro
            340                 345                 350         
Pro Ser Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu
        355                 360                 365             
Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn
    370                 375                 380                 
Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser
385                 390                 395                 400 
Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg
                405                 410                 415     
Trp Gln Glu Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu
            420                 425                 430         
His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly Lys Gly
        435                 440                 445             
Gly Gly Gly Ser Gly Gly Gly Ser Gln Val Lys Leu Glu Glu Ser Gly
    450                 455                 460                 
Gly Gly Leu Val Leu Pro Gly Glu Ser Leu Arg Leu Ser Cys Glu Ala
465                 470                 475                 480 
Ser Gly Arg Thr Ile Thr Thr Ile Thr Met Gly Trp Phe Arg Gln Ala
                485                 490                 495     
Pro Gly Lys Glu Arg Gln Phe Val Ala Ser His Ser Trp Thr Asp Asn
            500                 505                 510         
Asn Pro Tyr Tyr Ala Asp Ser Val Lys Gly Arg Phe Ile Ile Ser Arg
        515                 520                 525             
Asp Asn Ala Gly Asn Arg Val Tyr Leu Gln Met His Ser Leu Glu Pro
    530                 535                 540                 
Glu Asp Thr Ala Val Tyr Tyr Cys Ala Ala Thr Ala Arg Arg Ser Phe
545                 550                 555                 560 
Val Gly Arg Gln Trp Tyr Thr Glu Ala Arg Gln Tyr Asp Tyr Trp Gly
                565                 570                 575     
Gln Gly Thr Gln Val Thr Val Ser Ser
            580                 585 


<210> 135
<211> 585
<212> PRT
<213> Artificial Sequence

<220> 
<223> BCP-311K (A34311-9GS-Keytruda) heavy chain fusion sequence

<400> 135
Gln Val Lys Leu Glu Glu Ser Gly Gly Gly Leu Val Leu Pro Gly Glu
 1               5                  10                  15      
Ser Leu Arg Leu Ser Cys Glu Ala Ser Gly Arg Thr Ile Thr Thr Ile
            20                  25                  30          
Thr Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Gln Phe Val
        35                  40                  45              
Ala Ser His Ser Trp Thr Asp Asn Asn Pro Tyr Tyr Ala Asp Ser Val
    50                  55                  60                  
Lys Gly Arg Phe Ile Ile Ser Arg Asp Asn Ala Gly Asn Arg Val Tyr
65                  70                  75                  80  
Leu Gln Met His Ser Leu Glu Pro Glu Asp Thr Ala Val Tyr Tyr Cys
                85                  90                  95      
Ala Ala Thr Ala Arg Arg Ser Phe Val Gly Arg Gln Trp Tyr Thr Glu
            100                 105                 110         
Ala Arg Gln Tyr Asp Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser
        115                 120                 125             
Ser Gly Gly Gly Gly Ser Gly Gly Gly Ser Gln Val Gln Leu Val Gln
    130                 135                 140                 
Ser Gly Val Glu Val Lys Lys Pro Gly Ala Ser Val Lys Val Ser Cys
145                 150                 155                 160 
Lys Ala Ser Gly Tyr Thr Phe Thr Asn Tyr Tyr Met Tyr Trp Val Arg
                165                 170                 175     
Gln Ala Pro Gly Gln Gly Leu Glu Trp Met Gly Gly Ile Asn Pro Ser
            180                 185                 190         
Asn Gly Gly Thr Asn Phe Asn Glu Lys Phe Lys Asn Arg Val Thr Leu
        195                 200                 205             
Thr Thr Asp Ser Ser Thr Thr Thr Ala Tyr Met Glu Leu Lys Ser Leu
    210                 215                 220                 
Gln Phe Asp Asp Thr Ala Val Tyr Tyr Cys Ala Arg Arg Asp Tyr Arg
225                 230                 235                 240 
Phe Asp Met Gly Phe Asp Tyr Trp Gly Gln Gly Thr Thr Val Thr Val
                245                 250                 255     
Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Cys
            260                 265                 270         
Ser Arg Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly Cys Leu Val Lys
        275                 280                 285             
Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu
    290                 295                 300                 
Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu
305                 310                 315                 320 
Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr
                325                 330                 335     
Lys Thr Tyr Thr Cys Asn Val Asp His Lys Pro Ser Asn Thr Lys Val
            340                 345                 350         
Asp Lys Arg Val Glu Ser Lys Tyr Gly Pro Pro Cys Pro Pro Cys Pro
        355                 360                 365             
Ala Pro Glu Phe Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys
    370                 375                 380                 
Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val
385                 390                 395                 400 
Val Val Asp Val Ser Gln Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr
                405                 410                 415     
Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu
            420                 425                 430         
Gln Phe Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His
        435                 440                 445             
Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys
    450                 455                 460                 
Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln
465                 470                 475                 480 
Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met
                485                 490                 495     
Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro
            500                 505                 510         
Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn
        515                 520                 525             
Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu
    530                 535                 540                 
Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg Trp Gln Glu Gly Asn Val
545                 550                 555                 560 
Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln
                565                 570                 575     
Lys Ser Leu Ser Leu Ser Leu Gly Lys
            580                 585 


<210> 136
<211> 591
<212> PRT
<213> Artificial Sequence

<220> 
<223> Keytruda-hIgG1 hinge-A34311 heavy chain fusion sequence

<400> 136
Gln Val Gln Leu Val Gln Ser Gly Val Glu Val Lys Lys Pro Gly Ala
 1               5                  10                  15      
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asn Tyr
            20                  25                  30          
Tyr Met Tyr Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met
        35                  40                  45              
Gly Gly Ile Asn Pro Ser Asn Gly Gly Thr Asn Phe Asn Glu Lys Phe
    50                  55                  60                  
Lys Asn Arg Val Thr Leu Thr Thr Asp Ser Ser Thr Thr Thr Ala Tyr
65                  70                  75                  80  
Met Glu Leu Lys Ser Leu Gln Phe Asp Asp Thr Ala Val Tyr Tyr Cys
                85                  90                  95      
Ala Arg Arg Asp Tyr Arg Phe Asp Met Gly Phe Asp Tyr Trp Gly Gln
            100                 105                 110         
Gly Thr Thr Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val
        115                 120                 125             
Phe Pro Leu Ala Pro Cys Ser Arg Ser Thr Ser Glu Ser Thr Ala Ala
    130                 135                 140                 
Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser
145                 150                 155                 160 
Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val
                165                 170                 175     
Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro
            180                 185                 190         
Ser Ser Ser Leu Gly Thr Lys Thr Tyr Thr Cys Asn Val Asp His Lys
        195                 200                 205             
Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu Ser Lys Tyr Gly Pro
    210                 215                 220                 
Pro Cys Pro Pro Cys Pro Ala Pro Glu Phe Leu Gly Gly Pro Ser Val
225                 230                 235                 240 
Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr
                245                 250                 255     
Pro Glu Val Thr Cys Val Val Val Asp Val Ser Gln Glu Asp Pro Glu
            260                 265                 270         
Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys
        275                 280                 285             
Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser
    290                 295                 300                 
Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys
305                 310                 315                 320 
Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile
                325                 330                 335     
Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro
            340                 345                 350         
Pro Ser Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu
        355                 360                 365             
Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn
    370                 375                 380                 
Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser
385                 390                 395                 400 
Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg
                405                 410                 415     
Trp Gln Glu Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu
            420                 425                 430         
His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly Lys Glu
        435                 440                 445             
Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Gln Val
    450                 455                 460                 
Lys Leu Glu Glu Ser Gly Gly Gly Leu Val Leu Pro Gly Glu Ser Leu
465                 470                 475                 480 
Arg Leu Ser Cys Glu Ala Ser Gly Arg Thr Ile Thr Thr Ile Thr Met
                485                 490                 495     
Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Gln Phe Val Ala Ser
            500                 505                 510         
His Ser Trp Thr Asp Asn Asn Pro Tyr Tyr Ala Asp Ser Val Lys Gly
        515                 520                 525             
Arg Phe Ile Ile Ser Arg Asp Asn Ala Gly Asn Arg Val Tyr Leu Gln
    530                 535                 540                 
Met His Ser Leu Glu Pro Glu Asp Thr Ala Val Tyr Tyr Cys Ala Ala
545                 550                 555                 560 
Thr Ala Arg Arg Ser Phe Val Gly Arg Gln Trp Tyr Thr Glu Ala Arg
                565                 570                 575     
Gln Tyr Asp Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser
            580                 585                 590     


<210> 137
<211> 591
<212> PRT
<213> Artificial Sequence

<220> 
<223> A34311-hIgG1 hinge-Keytruda heavy chain fusion sequence

<400> 137
Gln Val Lys Leu Glu Glu Ser Gly Gly Gly Leu Val Leu Pro Gly Glu
 1               5                  10                  15      
Ser Leu Arg Leu Ser Cys Glu Ala Ser Gly Arg Thr Ile Thr Thr Ile
            20                  25                  30          
Thr Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Gln Phe Val
        35                  40                  45              
Ala Ser His Ser Trp Thr Asp Asn Asn Pro Tyr Tyr Ala Asp Ser Val
    50                  55                  60                  
Lys Gly Arg Phe Ile Ile Ser Arg Asp Asn Ala Gly Asn Arg Val Tyr
65                  70                  75                  80  
Leu Gln Met His Ser Leu Glu Pro Glu Asp Thr Ala Val Tyr Tyr Cys
                85                  90                  95      
Ala Ala Thr Ala Arg Arg Ser Phe Val Gly Arg Gln Trp Tyr Thr Glu
            100                 105                 110         
Ala Arg Gln Tyr Asp Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser
        115                 120                 125             
Ser Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro
    130                 135                 140                 
Gln Val Gln Leu Val Gln Ser Gly Val Glu Val Lys Lys Pro Gly Ala
145                 150                 155                 160 
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asn Tyr
                165                 170                 175     
Tyr Met Tyr Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met
            180                 185                 190         
Gly Gly Ile Asn Pro Ser Asn Gly Gly Thr Asn Phe Asn Glu Lys Phe
        195                 200                 205             
Lys Asn Arg Val Thr Leu Thr Thr Asp Ser Ser Thr Thr Thr Ala Tyr
    210                 215                 220                 
Met Glu Leu Lys Ser Leu Gln Phe Asp Asp Thr Ala Val Tyr Tyr Cys
225                 230                 235                 240 
Ala Arg Arg Asp Tyr Arg Phe Asp Met Gly Phe Asp Tyr Trp Gly Gln
                245                 250                 255     
Gly Thr Thr Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val
            260                 265                 270         
Phe Pro Leu Ala Pro Cys Ser Arg Ser Thr Ser Glu Ser Thr Ala Ala
        275                 280                 285             
Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser
    290                 295                 300                 
Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val
305                 310                 315                 320 
Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro
                325                 330                 335     
Ser Ser Ser Leu Gly Thr Lys Thr Tyr Thr Cys Asn Val Asp His Lys
            340                 345                 350         
Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu Ser Lys Tyr Gly Pro
        355                 360                 365             
Pro Cys Pro Pro Cys Pro Ala Pro Glu Phe Leu Gly Gly Pro Ser Val
    370                 375                 380                 
Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr
385                 390                 395                 400 
Pro Glu Val Thr Cys Val Val Val Asp Val Ser Gln Glu Asp Pro Glu
                405                 410                 415     
Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys
            420                 425                 430         
Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser
        435                 440                 445             
Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys
    450                 455                 460                 
Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile
465                 470                 475                 480 
Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro
                485                 490                 495     
Pro Ser Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu
            500                 505                 510         
Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn
        515                 520                 525             
Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser
    530                 535                 540                 
Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg
545                 550                 555                 560 
Trp Gln Glu Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu
                565                 570                 575     
His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly Lys
            580                 585                 590     


<210> 138
<211> 576
<212> PRT
<213> Artificial Sequence

<220> 
<223> Keytruda-A34311 heavy chain fusion sequence

<400> 138
Gln Val Gln Leu Val Gln Ser Gly Val Glu Val Lys Lys Pro Gly Ala
 1               5                  10                  15      
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asn Tyr
            20                  25                  30          
Tyr Met Tyr Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met
        35                  40                  45              
Gly Gly Ile Asn Pro Ser Asn Gly Gly Thr Asn Phe Asn Glu Lys Phe
    50                  55                  60                  
Lys Asn Arg Val Thr Leu Thr Thr Asp Ser Ser Thr Thr Thr Ala Tyr
65                  70                  75                  80  
Met Glu Leu Lys Ser Leu Gln Phe Asp Asp Thr Ala Val Tyr Tyr Cys
                85                  90                  95      
Ala Arg Arg Asp Tyr Arg Phe Asp Met Gly Phe Asp Tyr Trp Gly Gln
            100                 105                 110         
Gly Thr Thr Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val
        115                 120                 125             
Phe Pro Leu Ala Pro Cys Ser Arg Ser Thr Ser Glu Ser Thr Ala Ala
    130                 135                 140                 
Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser
145                 150                 155                 160 
Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val
                165                 170                 175     
Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro
            180                 185                 190         
Ser Ser Ser Leu Gly Thr Lys Thr Tyr Thr Cys Asn Val Asp His Lys
        195                 200                 205             
Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu Ser Lys Tyr Gly Pro
    210                 215                 220                 
Pro Cys Pro Pro Cys Pro Ala Pro Glu Phe Leu Gly Gly Pro Ser Val
225                 230                 235                 240 
Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr
                245                 250                 255     
Pro Glu Val Thr Cys Val Val Val Asp Val Ser Gln Glu Asp Pro Glu
            260                 265                 270         
Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys
        275                 280                 285             
Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser
    290                 295                 300                 
Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys
305                 310                 315                 320 
Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile
                325                 330                 335     
Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro
            340                 345                 350         
Pro Ser Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu
        355                 360                 365             
Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn
    370                 375                 380                 
Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser
385                 390                 395                 400 
Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg
                405                 410                 415     
Trp Gln Glu Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu
            420                 425                 430         
His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly Lys Gln
        435                 440                 445             
Val Lys Leu Glu Glu Ser Gly Gly Gly Leu Val Leu Pro Gly Glu Ser
    450                 455                 460                 
Leu Arg Leu Ser Cys Glu Ala Ser Gly Arg Thr Ile Thr Thr Ile Thr
465                 470                 475                 480 
Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Gln Phe Val Ala
                485                 490                 495     
Ser His Ser Trp Thr Asp Asn Asn Pro Tyr Tyr Ala Asp Ser Val Lys
            500                 505                 510         
Gly Arg Phe Ile Ile Ser Arg Asp Asn Ala Gly Asn Arg Val Tyr Leu
        515                 520                 525             
Gln Met His Ser Leu Glu Pro Glu Asp Thr Ala Val Tyr Tyr Cys Ala
    530                 535                 540                 
Ala Thr Ala Arg Arg Ser Phe Val Gly Arg Gln Trp Tyr Thr Glu Ala
545                 550                 555                 560 
Arg Gln Tyr Asp Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser
                565                 570                 575     


<210> 139
<211> 576
<212> PRT
<213> Artificial Sequence

<220> 
<223> A34311-Keytruda heavy chain fusion sequence

<400> 139
Gln Val Lys Leu Glu Glu Ser Gly Gly Gly Leu Val Leu Pro Gly Glu
 1               5                  10                  15      
Ser Leu Arg Leu Ser Cys Glu Ala Ser Gly Arg Thr Ile Thr Thr Ile
            20                  25                  30          
Thr Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Gln Phe Val
        35                  40                  45              
Ala Ser His Ser Trp Thr Asp Asn Asn Pro Tyr Tyr Ala Asp Ser Val
    50                  55                  60                  
Lys Gly Arg Phe Ile Ile Ser Arg Asp Asn Ala Gly Asn Arg Val Tyr
65                  70                  75                  80  
Leu Gln Met His Ser Leu Glu Pro Glu Asp Thr Ala Val Tyr Tyr Cys
                85                  90                  95      
Ala Ala Thr Ala Arg Arg Ser Phe Val Gly Arg Gln Trp Tyr Thr Glu
            100                 105                 110         
Ala Arg Gln Tyr Asp Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser
        115                 120                 125             
Ser Gln Val Gln Leu Val Gln Ser Gly Val Glu Val Lys Lys Pro Gly
    130                 135                 140                 
Ala Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asn
145                 150                 155                 160 
Tyr Tyr Met Tyr Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp
                165                 170                 175     
Met Gly Gly Ile Asn Pro Ser Asn Gly Gly Thr Asn Phe Asn Glu Lys
            180                 185                 190         
Phe Lys Asn Arg Val Thr Leu Thr Thr Asp Ser Ser Thr Thr Thr Ala
        195                 200                 205             
Tyr Met Glu Leu Lys Ser Leu Gln Phe Asp Asp Thr Ala Val Tyr Tyr
    210                 215                 220                 
Cys Ala Arg Arg Asp Tyr Arg Phe Asp Met Gly Phe Asp Tyr Trp Gly
225                 230                 235                 240 
Gln Gly Thr Thr Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser
                245                 250                 255     
Val Phe Pro Leu Ala Pro Cys Ser Arg Ser Thr Ser Glu Ser Thr Ala
            260                 265                 270         
Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val
        275                 280                 285             
Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala
    290                 295                 300                 
Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val
305                 310                 315                 320 
Pro Ser Ser Ser Leu Gly Thr Lys Thr Tyr Thr Cys Asn Val Asp His
                325                 330                 335     
Lys Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu Ser Lys Tyr Gly
            340                 345                 350         
Pro Pro Cys Pro Pro Cys Pro Ala Pro Glu Phe Leu Gly Gly Pro Ser
        355                 360                 365             
Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg
    370                 375                 380                 
Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser Gln Glu Asp Pro
385                 390                 395                 400 
Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala
                405                 410                 415     
Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val
            420                 425                 430         
Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr
        435                 440                 445             
Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr
    450                 455                 460                 
Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu
465                 470                 475                 480 
Pro Pro Ser Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys
                485                 490                 495     
Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser
            500                 505                 510         
Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp
        515                 520                 525             
Ser Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser
    530                 535                 540                 
Arg Trp Gln Glu Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala
545                 550                 555                 560 
Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly Lys
                565                 570                 575     


<210> 140
<211> 585
<212> PRT
<213> Artificial Sequence

<220> 
<223> Keytruda-9GS-AS02640 heavy chain fusion sequence

<400> 140
Gln Val Gln Leu Val Gln Ser Gly Val Glu Val Lys Lys Pro Gly Ala
 1               5                  10                  15      
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asn Tyr
            20                  25                  30          
Tyr Met Tyr Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met
        35                  40                  45              
Gly Gly Ile Asn Pro Ser Asn Gly Gly Thr Asn Phe Asn Glu Lys Phe
    50                  55                  60                  
Lys Asn Arg Val Thr Leu Thr Thr Asp Ser Ser Thr Thr Thr Ala Tyr
65                  70                  75                  80  
Met Glu Leu Lys Ser Leu Gln Phe Asp Asp Thr Ala Val Tyr Tyr Cys
                85                  90                  95      
Ala Arg Arg Asp Tyr Arg Phe Asp Met Gly Phe Asp Tyr Trp Gly Gln
            100                 105                 110         
Gly Thr Thr Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val
        115                 120                 125             
Phe Pro Leu Ala Pro Cys Ser Arg Ser Thr Ser Glu Ser Thr Ala Ala
    130                 135                 140                 
Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser
145                 150                 155                 160 
Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val
                165                 170                 175     
Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro
            180                 185                 190         
Ser Ser Ser Leu Gly Thr Lys Thr Tyr Thr Cys Asn Val Asp His Lys
        195                 200                 205             
Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu Ser Lys Tyr Gly Pro
    210                 215                 220                 
Pro Cys Pro Pro Cys Pro Ala Pro Glu Phe Leu Gly Gly Pro Ser Val
225                 230                 235                 240 
Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr
                245                 250                 255     
Pro Glu Val Thr Cys Val Val Val Asp Val Ser Gln Glu Asp Pro Glu
            260                 265                 270         
Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys
        275                 280                 285             
Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser
    290                 295                 300                 
Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys
305                 310                 315                 320 
Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile
                325                 330                 335     
Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro
            340                 345                 350         
Pro Ser Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu
        355                 360                 365             
Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn
    370                 375                 380                 
Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser
385                 390                 395                 400 
Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg
                405                 410                 415     
Trp Gln Glu Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu
            420                 425                 430         
His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly Lys Gly
        435                 440                 445             
Gly Gly Gly Ser Gly Gly Gly Ser Gln Val Gln Leu Val Glu Ser Gly
    450                 455                 460                 
Gly Gly Val Val Gln Pro Gly Arg Ser Leu Arg Leu Ser Cys Ala Ala
465                 470                 475                 480 
Ser Gly Arg Thr Ile Thr Thr Ile Thr Met Gly Trp Phe Arg Gln Ala
                485                 490                 495     
Pro Gly Lys Gly Leu Glu Phe Val Ala Ser His Ser Trp Thr Asp Asn
            500                 505                 510         
Asn Pro Tyr Tyr Ala Asp Ser Val Lys Gly Arg Phe Ile Ile Ser Arg
        515                 520                 525             
Asp Asn Ser Lys Asn Arg Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala
    530                 535                 540                 
Glu Asp Thr Ala Val Tyr Tyr Cys Ala Ala Thr Ala Arg Arg Ser Phe
545                 550                 555                 560 
Val Gly Arg Gln Trp Tyr Thr Glu Ala Arg Gln Tyr Asp Tyr Trp Gly
                565                 570                 575     
Gln Gly Thr Leu Val Thr Val Ser Ser
            580                 585 


<210> 141
<211> 585
<212> PRT
<213> Artificial Sequence

<220> 
<223> AS02640-9GS-Keytruda heavy chain fusion sequence

<400> 141
Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg
 1               5                  10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Thr Ile Thr Thr Ile
            20                  25                  30          
Thr Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Gly Leu Glu Phe Val
        35                  40                  45              
Ala Ser His Ser Trp Thr Asp Asn Asn Pro Tyr Tyr Ala Asp Ser Val
    50                  55                  60                  
Lys Gly Arg Phe Ile Ile Ser Arg Asp Asn Ser Lys Asn Arg Leu Tyr
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
                85                  90                  95      
Ala Ala Thr Ala Arg Arg Ser Phe Val Gly Arg Gln Trp Tyr Thr Glu
            100                 105                 110         
Ala Arg Gln Tyr Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser
        115                 120                 125             
Ser Gly Gly Gly Gly Ser Gly Gly Gly Ser Gln Val Gln Leu Val Gln
    130                 135                 140                 
Ser Gly Val Glu Val Lys Lys Pro Gly Ala Ser Val Lys Val Ser Cys
145                 150                 155                 160 
Lys Ala Ser Gly Tyr Thr Phe Thr Asn Tyr Tyr Met Tyr Trp Val Arg
                165                 170                 175     
Gln Ala Pro Gly Gln Gly Leu Glu Trp Met Gly Gly Ile Asn Pro Ser
            180                 185                 190         
Asn Gly Gly Thr Asn Phe Asn Glu Lys Phe Lys Asn Arg Val Thr Leu
        195                 200                 205             
Thr Thr Asp Ser Ser Thr Thr Thr Ala Tyr Met Glu Leu Lys Ser Leu
    210                 215                 220                 
Gln Phe Asp Asp Thr Ala Val Tyr Tyr Cys Ala Arg Arg Asp Tyr Arg
225                 230                 235                 240 
Phe Asp Met Gly Phe Asp Tyr Trp Gly Gln Gly Thr Thr Val Thr Val
                245                 250                 255     
Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Cys
            260                 265                 270         
Ser Arg Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly Cys Leu Val Lys
        275                 280                 285             
Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu
    290                 295                 300                 
Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu
305                 310                 315                 320 
Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr
                325                 330                 335     
Lys Thr Tyr Thr Cys Asn Val Asp His Lys Pro Ser Asn Thr Lys Val
            340                 345                 350         
Asp Lys Arg Val Glu Ser Lys Tyr Gly Pro Pro Cys Pro Pro Cys Pro
        355                 360                 365             
Ala Pro Glu Phe Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys
    370                 375                 380                 
Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val
385                 390                 395                 400 
Val Val Asp Val Ser Gln Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr
                405                 410                 415     
Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu
            420                 425                 430         
Gln Phe Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His
        435                 440                 445             
Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys
    450                 455                 460                 
Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln
465                 470                 475                 480 
Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met
                485                 490                 495     
Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro
            500                 505                 510         
Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn
        515                 520                 525             
Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu
    530                 535                 540                 
Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg Trp Gln Glu Gly Asn Val
545                 550                 555                 560 
Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln
                565                 570                 575     
Lys Ser Leu Ser Leu Ser Leu Gly Lys
            580                 585 


<210> 142
<211> 591
<212> PRT
<213> Artificial Sequence

<220> 
<223> Keytruda-hIgG1 hinge-AS02640 heavy chain fusion sequence

<400> 142
Gln Val Gln Leu Val Gln Ser Gly Val Glu Val Lys Lys Pro Gly Ala
 1               5                  10                  15      
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asn Tyr
            20                  25                  30          
Tyr Met Tyr Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met
        35                  40                  45              
Gly Gly Ile Asn Pro Ser Asn Gly Gly Thr Asn Phe Asn Glu Lys Phe
    50                  55                  60                  
Lys Asn Arg Val Thr Leu Thr Thr Asp Ser Ser Thr Thr Thr Ala Tyr
65                  70                  75                  80  
Met Glu Leu Lys Ser Leu Gln Phe Asp Asp Thr Ala Val Tyr Tyr Cys
                85                  90                  95      
Ala Arg Arg Asp Tyr Arg Phe Asp Met Gly Phe Asp Tyr Trp Gly Gln
            100                 105                 110         
Gly Thr Thr Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val
        115                 120                 125             
Phe Pro Leu Ala Pro Cys Ser Arg Ser Thr Ser Glu Ser Thr Ala Ala
    130                 135                 140                 
Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser
145                 150                 155                 160 
Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val
                165                 170                 175     
Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro
            180                 185                 190         
Ser Ser Ser Leu Gly Thr Lys Thr Tyr Thr Cys Asn Val Asp His Lys
        195                 200                 205             
Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu Ser Lys Tyr Gly Pro
    210                 215                 220                 
Pro Cys Pro Pro Cys Pro Ala Pro Glu Phe Leu Gly Gly Pro Ser Val
225                 230                 235                 240 
Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr
                245                 250                 255     
Pro Glu Val Thr Cys Val Val Val Asp Val Ser Gln Glu Asp Pro Glu
            260                 265                 270         
Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys
        275                 280                 285             
Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser
    290                 295                 300                 
Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys
305                 310                 315                 320 
Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile
                325                 330                 335     
Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro
            340                 345                 350         
Pro Ser Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu
        355                 360                 365             
Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn
    370                 375                 380                 
Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser
385                 390                 395                 400 
Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg
                405                 410                 415     
Trp Gln Glu Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu
            420                 425                 430         
His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly Lys Glu
        435                 440                 445             
Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Gln Val
    450                 455                 460                 
Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg Ser Leu
465                 470                 475                 480 
Arg Leu Ser Cys Ala Ala Ser Gly Arg Thr Ile Thr Thr Ile Thr Met
                485                 490                 495     
Gly Trp Phe Arg Gln Ala Pro Gly Lys Gly Leu Glu Phe Val Ala Ser
            500                 505                 510         
His Ser Trp Thr Asp Asn Asn Pro Tyr Tyr Ala Asp Ser Val Lys Gly
        515                 520                 525             
Arg Phe Ile Ile Ser Arg Asp Asn Ser Lys Asn Arg Leu Tyr Leu Gln
    530                 535                 540                 
Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Ala
545                 550                 555                 560 
Thr Ala Arg Arg Ser Phe Val Gly Arg Gln Trp Tyr Thr Glu Ala Arg
                565                 570                 575     
Gln Tyr Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser
            580                 585                 590     


<210> 143
<211> 591
<212> PRT
<213> Artificial Sequence

<220> 
<223> AS02640-hIgG1 hinge-Keytruda heavy chain fusion sequence

<400> 143
Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg
 1               5                  10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Thr Ile Thr Thr Ile
            20                  25                  30          
Thr Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Gly Leu Glu Phe Val
        35                  40                  45              
Ala Ser His Ser Trp Thr Asp Asn Asn Pro Tyr Tyr Ala Asp Ser Val
    50                  55                  60                  
Lys Gly Arg Phe Ile Ile Ser Arg Asp Asn Ser Lys Asn Arg Leu Tyr
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
                85                  90                  95      
Ala Ala Thr Ala Arg Arg Ser Phe Val Gly Arg Gln Trp Tyr Thr Glu
            100                 105                 110         
Ala Arg Gln Tyr Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser
        115                 120                 125             
Ser Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro
    130                 135                 140                 
Gln Val Gln Leu Val Gln Ser Gly Val Glu Val Lys Lys Pro Gly Ala
145                 150                 155                 160 
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asn Tyr
                165                 170                 175     
Tyr Met Tyr Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met
            180                 185                 190         
Gly Gly Ile Asn Pro Ser Asn Gly Gly Thr Asn Phe Asn Glu Lys Phe
        195                 200                 205             
Lys Asn Arg Val Thr Leu Thr Thr Asp Ser Ser Thr Thr Thr Ala Tyr
    210                 215                 220                 
Met Glu Leu Lys Ser Leu Gln Phe Asp Asp Thr Ala Val Tyr Tyr Cys
225                 230                 235                 240 
Ala Arg Arg Asp Tyr Arg Phe Asp Met Gly Phe Asp Tyr Trp Gly Gln
                245                 250                 255     
Gly Thr Thr Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val
            260                 265                 270         
Phe Pro Leu Ala Pro Cys Ser Arg Ser Thr Ser Glu Ser Thr Ala Ala
        275                 280                 285             
Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser
    290                 295                 300                 
Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val
305                 310                 315                 320 
Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro
                325                 330                 335     
Ser Ser Ser Leu Gly Thr Lys Thr Tyr Thr Cys Asn Val Asp His Lys
            340                 345                 350         
Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu Ser Lys Tyr Gly Pro
        355                 360                 365             
Pro Cys Pro Pro Cys Pro Ala Pro Glu Phe Leu Gly Gly Pro Ser Val
    370                 375                 380                 
Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr
385                 390                 395                 400 
Pro Glu Val Thr Cys Val Val Val Asp Val Ser Gln Glu Asp Pro Glu
                405                 410                 415     
Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys
            420                 425                 430         
Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser
        435                 440                 445             
Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys
    450                 455                 460                 
Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile
465                 470                 475                 480 
Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro
                485                 490                 495     
Pro Ser Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu
            500                 505                 510         
Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn
        515                 520                 525             
Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser
    530                 535                 540                 
Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg
545                 550                 555                 560 
Trp Gln Glu Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu
                565                 570                 575     
His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly Lys
            580                 585                 590     


<210> 144
<211> 576
<212> PRT
<213> Artificial Sequence

<220> 
<223> Keytruda-AS02640 heavy chain fusion sequence

<400> 144
Gln Val Gln Leu Val Gln Ser Gly Val Glu Val Lys Lys Pro Gly Ala
 1               5                  10                  15      
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asn Tyr
            20                  25                  30          
Tyr Met Tyr Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met
        35                  40                  45              
Gly Gly Ile Asn Pro Ser Asn Gly Gly Thr Asn Phe Asn Glu Lys Phe
    50                  55                  60                  
Lys Asn Arg Val Thr Leu Thr Thr Asp Ser Ser Thr Thr Thr Ala Tyr
65                  70                  75                  80  
Met Glu Leu Lys Ser Leu Gln Phe Asp Asp Thr Ala Val Tyr Tyr Cys
                85                  90                  95      
Ala Arg Arg Asp Tyr Arg Phe Asp Met Gly Phe Asp Tyr Trp Gly Gln
            100                 105                 110         
Gly Thr Thr Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val
        115                 120                 125             
Phe Pro Leu Ala Pro Cys Ser Arg Ser Thr Ser Glu Ser Thr Ala Ala
    130                 135                 140                 
Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser
145                 150                 155                 160 
Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val
                165                 170                 175     
Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro
            180                 185                 190         
Ser Ser Ser Leu Gly Thr Lys Thr Tyr Thr Cys Asn Val Asp His Lys
        195                 200                 205             
Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu Ser Lys Tyr Gly Pro
    210                 215                 220                 
Pro Cys Pro Pro Cys Pro Ala Pro Glu Phe Leu Gly Gly Pro Ser Val
225                 230                 235                 240 
Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr
                245                 250                 255     
Pro Glu Val Thr Cys Val Val Val Asp Val Ser Gln Glu Asp Pro Glu
            260                 265                 270         
Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys
        275                 280                 285             
Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser
    290                 295                 300                 
Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys
305                 310                 315                 320 
Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile
                325                 330                 335     
Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro
            340                 345                 350         
Pro Ser Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu
        355                 360                 365             
Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn
    370                 375                 380                 
Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser
385                 390                 395                 400 
Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg
                405                 410                 415     
Trp Gln Glu Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu
            420                 425                 430         
His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly Lys Gln
        435                 440                 445             
Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg Ser
    450                 455                 460                 
Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Thr Ile Thr Thr Ile Thr
465                 470                 475                 480 
Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Gly Leu Glu Phe Val Ala
                485                 490                 495     
Ser His Ser Trp Thr Asp Asn Asn Pro Tyr Tyr Ala Asp Ser Val Lys
            500                 505                 510         
Gly Arg Phe Ile Ile Ser Arg Asp Asn Ser Lys Asn Arg Leu Tyr Leu
        515                 520                 525             
Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala
    530                 535                 540                 
Ala Thr Ala Arg Arg Ser Phe Val Gly Arg Gln Trp Tyr Thr Glu Ala
545                 550                 555                 560 
Arg Gln Tyr Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser
                565                 570                 575     


<210> 145
<211> 576
<212> PRT
<213> Artificial Sequence

<220> 
<223> AS02640-Keytruda heavy chain fusion sequence

<400> 145
Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg
 1               5                  10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Thr Ile Thr Thr Ile
            20                  25                  30          
Thr Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Gly Leu Glu Phe Val
        35                  40                  45              
Ala Ser His Ser Trp Thr Asp Asn Asn Pro Tyr Tyr Ala Asp Ser Val
    50                  55                  60                  
Lys Gly Arg Phe Ile Ile Ser Arg Asp Asn Ser Lys Asn Arg Leu Tyr
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
                85                  90                  95      
Ala Ala Thr Ala Arg Arg Ser Phe Val Gly Arg Gln Trp Tyr Thr Glu
            100                 105                 110         
Ala Arg Gln Tyr Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser
        115                 120                 125             
Ser Gln Val Gln Leu Val Gln Ser Gly Val Glu Val Lys Lys Pro Gly
    130                 135                 140                 
Ala Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asn
145                 150                 155                 160 
Tyr Tyr Met Tyr Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp
                165                 170                 175     
Met Gly Gly Ile Asn Pro Ser Asn Gly Gly Thr Asn Phe Asn Glu Lys
            180                 185                 190         
Phe Lys Asn Arg Val Thr Leu Thr Thr Asp Ser Ser Thr Thr Thr Ala
        195                 200                 205             
Tyr Met Glu Leu Lys Ser Leu Gln Phe Asp Asp Thr Ala Val Tyr Tyr
    210                 215                 220                 
Cys Ala Arg Arg Asp Tyr Arg Phe Asp Met Gly Phe Asp Tyr Trp Gly
225                 230                 235                 240 
Gln Gly Thr Thr Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser
                245                 250                 255     
Val Phe Pro Leu Ala Pro Cys Ser Arg Ser Thr Ser Glu Ser Thr Ala
            260                 265                 270         
Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val
        275                 280                 285             
Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala
    290                 295                 300                 
Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val
305                 310                 315                 320 
Pro Ser Ser Ser Leu Gly Thr Lys Thr Tyr Thr Cys Asn Val Asp His
                325                 330                 335     
Lys Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu Ser Lys Tyr Gly
            340                 345                 350         
Pro Pro Cys Pro Pro Cys Pro Ala Pro Glu Phe Leu Gly Gly Pro Ser
        355                 360                 365             
Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg
    370                 375                 380                 
Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser Gln Glu Asp Pro
385                 390                 395                 400 
Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala
                405                 410                 415     
Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val
            420                 425                 430         
Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr
        435                 440                 445             
Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr
    450                 455                 460                 
Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu
465                 470                 475                 480 
Pro Pro Ser Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys
                485                 490                 495     
Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser
            500                 505                 510         
Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp
        515                 520                 525             
Ser Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser
    530                 535                 540                 
Arg Trp Gln Glu Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala
545                 550                 555                 560 
Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly Lys
                565                 570                 575     


<210> 146
<211> 578
<212> PRT
<213> Artificial Sequence

<220> 
<223> Opdivo-9GS-A34311 heavy chain fusion sequence

<400> 146
Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg
 1               5                  10                  15      
Ser Leu Arg Leu Asp Cys Lys Ala Ser Gly Ile Thr Phe Ser Asn Ser
            20                  25                  30          
Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
        35                  40                  45              
Ala Val Ile Trp Tyr Asp Gly Ser Lys Arg Tyr Tyr Ala Asp Ser Val
    50                  55                  60                  
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Phe
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
                85                  90                  95      
Ala Thr Asn Asp Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser
            100                 105                 110         
Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Cys Ser
        115                 120                 125             
Arg Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly Cys Leu Val Lys Asp
    130                 135                 140                 
Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr
145                 150                 155                 160 
Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr
                165                 170                 175     
Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Lys
            180                 185                 190         
Thr Tyr Thr Cys Asn Val Asp His Lys Pro Ser Asn Thr Lys Val Asp
        195                 200                 205             
Lys Arg Val Glu Ser Lys Tyr Gly Pro Pro Cys Pro Pro Cys Pro Ala
    210                 215                 220                 
Pro Glu Phe Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro
225                 230                 235                 240 
Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val
                245                 250                 255     
Val Asp Val Ser Gln Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val
            260                 265                 270         
Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln
        275                 280                 285             
Phe Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln
    290                 295                 300                 
Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly
305                 310                 315                 320 
Leu Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro
                325                 330                 335     
Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met Thr
            340                 345                 350         
Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser
        355                 360                 365             
Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr
    370                 375                 380                 
Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr
385                 390                 395                 400 
Ser Arg Leu Thr Val Asp Lys Ser Arg Trp Gln Glu Gly Asn Val Phe
                405                 410                 415     
Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys
            420                 425                 430         
Ser Leu Ser Leu Ser Leu Gly Lys Gly Gly Gly Gly Ser Gly Gly Gly
        435                 440                 445             
Ser Gln Val Lys Leu Glu Glu Ser Gly Gly Gly Leu Val Leu Pro Gly
    450                 455                 460                 
Glu Ser Leu Arg Leu Ser Cys Glu Ala Ser Gly Arg Thr Ile Thr Thr
465                 470                 475                 480 
Ile Thr Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Gln Phe
                485                 490                 495     
Val Ala Ser His Ser Trp Thr Asp Asn Asn Pro Tyr Tyr Ala Asp Ser
            500                 505                 510         
Val Lys Gly Arg Phe Ile Ile Ser Arg Asp Asn Ala Gly Asn Arg Val
        515                 520                 525             
Tyr Leu Gln Met His Ser Leu Glu Pro Glu Asp Thr Ala Val Tyr Tyr
    530                 535                 540                 
Cys Ala Ala Thr Ala Arg Arg Ser Phe Val Gly Arg Gln Trp Tyr Thr
545                 550                 555                 560 
Glu Ala Arg Gln Tyr Asp Tyr Trp Gly Gln Gly Thr Gln Val Thr Val
                565                 570                 575     
Ser Ser
        


<210> 147
<211> 578
<212> PRT
<213> Artificial Sequence

<220> 
<223> A34311-9GS-Opdivo heavy chain fusion sequence

<400> 147
Gln Val Lys Leu Glu Glu Ser Gly Gly Gly Leu Val Leu Pro Gly Glu
 1               5                  10                  15      
Ser Leu Arg Leu Ser Cys Glu Ala Ser Gly Arg Thr Ile Thr Thr Ile
            20                  25                  30          
Thr Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Gln Phe Val
        35                  40                  45              
Ala Ser His Ser Trp Thr Asp Asn Asn Pro Tyr Tyr Ala Asp Ser Val
    50                  55                  60                  
Lys Gly Arg Phe Ile Ile Ser Arg Asp Asn Ala Gly Asn Arg Val Tyr
65                  70                  75                  80  
Leu Gln Met His Ser Leu Glu Pro Glu Asp Thr Ala Val Tyr Tyr Cys
                85                  90                  95      
Ala Ala Thr Ala Arg Arg Ser Phe Val Gly Arg Gln Trp Tyr Thr Glu
            100                 105                 110         
Ala Arg Gln Tyr Asp Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser
        115                 120                 125             
Ser Gly Gly Gly Gly Ser Gly Gly Gly Ser Gln Val Gln Leu Val Glu
    130                 135                 140                 
Ser Gly Gly Gly Val Val Gln Pro Gly Arg Ser Leu Arg Leu Asp Cys
145                 150                 155                 160 
Lys Ala Ser Gly Ile Thr Phe Ser Asn Ser Gly Met His Trp Val Arg
                165                 170                 175     
Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ala Val Ile Trp Tyr Asp
            180                 185                 190         
Gly Ser Lys Arg Tyr Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile
        195                 200                 205             
Ser Arg Asp Asn Ser Lys Asn Thr Leu Phe Leu Gln Met Asn Ser Leu
    210                 215                 220                 
Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Thr Asn Asp Asp Tyr
225                 230                 235                 240 
Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly
                245                 250                 255     
Pro Ser Val Phe Pro Leu Ala Pro Cys Ser Arg Ser Thr Ser Glu Ser
            260                 265                 270         
Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val
        275                 280                 285             
Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe
    290                 295                 300                 
Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val
305                 310                 315                 320 
Thr Val Pro Ser Ser Ser Leu Gly Thr Lys Thr Tyr Thr Cys Asn Val
                325                 330                 335     
Asp His Lys Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu Ser Lys
            340                 345                 350         
Tyr Gly Pro Pro Cys Pro Pro Cys Pro Ala Pro Glu Phe Leu Gly Gly
        355                 360                 365             
Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile
    370                 375                 380                 
Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser Gln Glu
385                 390                 395                 400 
Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His
                405                 410                 415     
Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg
            420                 425                 430         
Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys
        435                 440                 445             
Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu
    450                 455                 460                 
Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr
465                 470                 475                 480 
Thr Leu Pro Pro Ser Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu
                485                 490                 495     
Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp
            500                 505                 510         
Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val
        515                 520                 525             
Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp
    530                 535                 540                 
Lys Ser Arg Trp Gln Glu Gly Asn Val Phe Ser Cys Ser Val Met His
545                 550                 555                 560 
Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu
                565                 570                 575     
Gly Lys
        


<210> 148
<211> 584
<212> PRT
<213> Artificial Sequence

<220> 
<223> Opdivo-hIgG1 hinge-A34311 heavy chain fusion sequence

<400> 148
Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg
 1               5                  10                  15      
Ser Leu Arg Leu Asp Cys Lys Ala Ser Gly Ile Thr Phe Ser Asn Ser
            20                  25                  30          
Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
        35                  40                  45              
Ala Val Ile Trp Tyr Asp Gly Ser Lys Arg Tyr Tyr Ala Asp Ser Val
    50                  55                  60                  
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Phe
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
                85                  90                  95      
Ala Thr Asn Asp Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser
            100                 105                 110         
Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Cys Ser
        115                 120                 125             
Arg Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly Cys Leu Val Lys Asp
    130                 135                 140                 
Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr
145                 150                 155                 160 
Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr
                165                 170                 175     
Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Lys
            180                 185                 190         
Thr Tyr Thr Cys Asn Val Asp His Lys Pro Ser Asn Thr Lys Val Asp
        195                 200                 205             
Lys Arg Val Glu Ser Lys Tyr Gly Pro Pro Cys Pro Pro Cys Pro Ala
    210                 215                 220                 
Pro Glu Phe Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro
225                 230                 235                 240 
Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val
                245                 250                 255     
Val Asp Val Ser Gln Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val
            260                 265                 270         
Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln
        275                 280                 285             
Phe Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln
    290                 295                 300                 
Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly
305                 310                 315                 320 
Leu Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro
                325                 330                 335     
Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met Thr
            340                 345                 350         
Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser
        355                 360                 365             
Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr
    370                 375                 380                 
Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr
385                 390                 395                 400 
Ser Arg Leu Thr Val Asp Lys Ser Arg Trp Gln Glu Gly Asn Val Phe
                405                 410                 415     
Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys
            420                 425                 430         
Ser Leu Ser Leu Ser Leu Gly Lys Glu Pro Lys Ser Cys Asp Lys Thr
        435                 440                 445             
His Thr Cys Pro Pro Cys Pro Gln Val Lys Leu Glu Glu Ser Gly Gly
    450                 455                 460                 
Gly Leu Val Leu Pro Gly Glu Ser Leu Arg Leu Ser Cys Glu Ala Ser
465                 470                 475                 480 
Gly Arg Thr Ile Thr Thr Ile Thr Met Gly Trp Phe Arg Gln Ala Pro
                485                 490                 495     
Gly Lys Glu Arg Gln Phe Val Ala Ser His Ser Trp Thr Asp Asn Asn
            500                 505                 510         
Pro Tyr Tyr Ala Asp Ser Val Lys Gly Arg Phe Ile Ile Ser Arg Asp
        515                 520                 525             
Asn Ala Gly Asn Arg Val Tyr Leu Gln Met His Ser Leu Glu Pro Glu
    530                 535                 540                 
Asp Thr Ala Val Tyr Tyr Cys Ala Ala Thr Ala Arg Arg Ser Phe Val
545                 550                 555                 560 
Gly Arg Gln Trp Tyr Thr Glu Ala Arg Gln Tyr Asp Tyr Trp Gly Gln
                565                 570                 575     
Gly Thr Gln Val Thr Val Ser Ser
            580                 


<210> 149
<211> 584
<212> PRT
<213> Artificial Sequence

<220> 
<223> A34311-hIgG1 hinge-Opdivo heavy chain fusion sequence

<400> 149
Gln Val Lys Leu Glu Glu Ser Gly Gly Gly Leu Val Leu Pro Gly Glu
 1               5                  10                  15      
Ser Leu Arg Leu Ser Cys Glu Ala Ser Gly Arg Thr Ile Thr Thr Ile
            20                  25                  30          
Thr Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Gln Phe Val
        35                  40                  45              
Ala Ser His Ser Trp Thr Asp Asn Asn Pro Tyr Tyr Ala Asp Ser Val
    50                  55                  60                  
Lys Gly Arg Phe Ile Ile Ser Arg Asp Asn Ala Gly Asn Arg Val Tyr
65                  70                  75                  80  
Leu Gln Met His Ser Leu Glu Pro Glu Asp Thr Ala Val Tyr Tyr Cys
                85                  90                  95      
Ala Ala Thr Ala Arg Arg Ser Phe Val Gly Arg Gln Trp Tyr Thr Glu
            100                 105                 110         
Ala Arg Gln Tyr Asp Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser
        115                 120                 125             
Ser Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro
    130                 135                 140                 
Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg
145                 150                 155                 160 
Ser Leu Arg Leu Asp Cys Lys Ala Ser Gly Ile Thr Phe Ser Asn Ser
                165                 170                 175     
Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
            180                 185                 190         
Ala Val Ile Trp Tyr Asp Gly Ser Lys Arg Tyr Tyr Ala Asp Ser Val
        195                 200                 205             
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Phe
    210                 215                 220                 
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
225                 230                 235                 240 
Ala Thr Asn Asp Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser
                245                 250                 255     
Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Cys Ser
            260                 265                 270         
Arg Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly Cys Leu Val Lys Asp
        275                 280                 285             
Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr
    290                 295                 300                 
Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr
305                 310                 315                 320 
Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Lys
                325                 330                 335     
Thr Tyr Thr Cys Asn Val Asp His Lys Pro Ser Asn Thr Lys Val Asp
            340                 345                 350         
Lys Arg Val Glu Ser Lys Tyr Gly Pro Pro Cys Pro Pro Cys Pro Ala
        355                 360                 365             
Pro Glu Phe Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro
    370                 375                 380                 
Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val
385                 390                 395                 400 
Val Asp Val Ser Gln Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val
                405                 410                 415     
Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln
            420                 425                 430         
Phe Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln
        435                 440                 445             
Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly
    450                 455                 460                 
Leu Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro
465                 470                 475                 480 
Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met Thr
                485                 490                 495     
Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser
            500                 505                 510         
Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr
        515                 520                 525             
Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr
    530                 535                 540                 
Ser Arg Leu Thr Val Asp Lys Ser Arg Trp Gln Glu Gly Asn Val Phe
545                 550                 555                 560 
Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys
                565                 570                 575     
Ser Leu Ser Leu Ser Leu Gly Lys
            580                 


<210> 150
<211> 569
<212> PRT
<213> Artificial Sequence

<220> 
<223> Opdivo-A34311 heavy chain fusion sequence

<400> 150
Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg
 1               5                  10                  15      
Ser Leu Arg Leu Asp Cys Lys Ala Ser Gly Ile Thr Phe Ser Asn Ser
            20                  25                  30          
Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
        35                  40                  45              
Ala Val Ile Trp Tyr Asp Gly Ser Lys Arg Tyr Tyr Ala Asp Ser Val
    50                  55                  60                  
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Phe
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
                85                  90                  95      
Ala Thr Asn Asp Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser
            100                 105                 110         
Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Cys Ser
        115                 120                 125             
Arg Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly Cys Leu Val Lys Asp
    130                 135                 140                 
Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr
145                 150                 155                 160 
Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr
                165                 170                 175     
Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Lys
            180                 185                 190         
Thr Tyr Thr Cys Asn Val Asp His Lys Pro Ser Asn Thr Lys Val Asp
        195                 200                 205             
Lys Arg Val Glu Ser Lys Tyr Gly Pro Pro Cys Pro Pro Cys Pro Ala
    210                 215                 220                 
Pro Glu Phe Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro
225                 230                 235                 240 
Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val
                245                 250                 255     
Val Asp Val Ser Gln Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val
            260                 265                 270         
Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln
        275                 280                 285             
Phe Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln
    290                 295                 300                 
Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly
305                 310                 315                 320 
Leu Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro
                325                 330                 335     
Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met Thr
            340                 345                 350         
Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser
        355                 360                 365             
Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr
    370                 375                 380                 
Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr
385                 390                 395                 400 
Ser Arg Leu Thr Val Asp Lys Ser Arg Trp Gln Glu Gly Asn Val Phe
                405                 410                 415     
Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys
            420                 425                 430         
Ser Leu Ser Leu Ser Leu Gly Lys Gln Val Lys Leu Glu Glu Ser Gly
        435                 440                 445             
Gly Gly Leu Val Leu Pro Gly Glu Ser Leu Arg Leu Ser Cys Glu Ala
    450                 455                 460                 
Ser Gly Arg Thr Ile Thr Thr Ile Thr Met Gly Trp Phe Arg Gln Ala
465                 470                 475                 480 
Pro Gly Lys Glu Arg Gln Phe Val Ala Ser His Ser Trp Thr Asp Asn
                485                 490                 495     
Asn Pro Tyr Tyr Ala Asp Ser Val Lys Gly Arg Phe Ile Ile Ser Arg
            500                 505                 510         
Asp Asn Ala Gly Asn Arg Val Tyr Leu Gln Met His Ser Leu Glu Pro
        515                 520                 525             
Glu Asp Thr Ala Val Tyr Tyr Cys Ala Ala Thr Ala Arg Arg Ser Phe
    530                 535                 540                 
Val Gly Arg Gln Trp Tyr Thr Glu Ala Arg Gln Tyr Asp Tyr Trp Gly
545                 550                 555                 560 
Gln Gly Thr Gln Val Thr Val Ser Ser
                565                 


<210> 151
<211> 569
<212> PRT
<213> Artificial Sequence

<220> 
<223> A34311-Opdivo heavy chain fusion sequence

<400> 151
Gln Val Lys Leu Glu Glu Ser Gly Gly Gly Leu Val Leu Pro Gly Glu
 1               5                  10                  15      
Ser Leu Arg Leu Ser Cys Glu Ala Ser Gly Arg Thr Ile Thr Thr Ile
            20                  25                  30          
Thr Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Gln Phe Val
        35                  40                  45              
Ala Ser His Ser Trp Thr Asp Asn Asn Pro Tyr Tyr Ala Asp Ser Val
    50                  55                  60                  
Lys Gly Arg Phe Ile Ile Ser Arg Asp Asn Ala Gly Asn Arg Val Tyr
65                  70                  75                  80  
Leu Gln Met His Ser Leu Glu Pro Glu Asp Thr Ala Val Tyr Tyr Cys
                85                  90                  95      
Ala Ala Thr Ala Arg Arg Ser Phe Val Gly Arg Gln Trp Tyr Thr Glu
            100                 105                 110         
Ala Arg Gln Tyr Asp Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser
        115                 120                 125             
Ser Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly
    130                 135                 140                 
Arg Ser Leu Arg Leu Asp Cys Lys Ala Ser Gly Ile Thr Phe Ser Asn
145                 150                 155                 160 
Ser Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp
                165                 170                 175     
Val Ala Val Ile Trp Tyr Asp Gly Ser Lys Arg Tyr Tyr Ala Asp Ser
            180                 185                 190         
Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu
        195                 200                 205             
Phe Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr
    210                 215                 220                 
Cys Ala Thr Asn Asp Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val
225                 230                 235                 240 
Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Cys
                245                 250                 255     
Ser Arg Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly Cys Leu Val Lys
            260                 265                 270         
Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu
        275                 280                 285             
Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu
    290                 295                 300                 
Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr
305                 310                 315                 320 
Lys Thr Tyr Thr Cys Asn Val Asp His Lys Pro Ser Asn Thr Lys Val
                325                 330                 335     
Asp Lys Arg Val Glu Ser Lys Tyr Gly Pro Pro Cys Pro Pro Cys Pro
            340                 345                 350         
Ala Pro Glu Phe Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys
        355                 360                 365             
Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val
    370                 375                 380                 
Val Val Asp Val Ser Gln Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr
385                 390                 395                 400 
Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu
                405                 410                 415     
Gln Phe Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His
            420                 425                 430         
Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys
        435                 440                 445             
Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln
    450                 455                 460                 
Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met
465                 470                 475                 480 
Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro
                485                 490                 495     
Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn
            500                 505                 510         
Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu
        515                 520                 525             
Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg Trp Gln Glu Gly Asn Val
    530                 535                 540                 
Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln
545                 550                 555                 560 
Lys Ser Leu Ser Leu Ser Leu Gly Lys
                565                 


<210> 152
<211> 578
<212> PRT
<213> Artificial Sequence

<220> 
<223> Opdivo-9GS-AS02640 heavy chain fusion sequence

<400> 152
Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg
 1               5                  10                  15      
Ser Leu Arg Leu Asp Cys Lys Ala Ser Gly Ile Thr Phe Ser Asn Ser
            20                  25                  30          
Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
        35                  40                  45              
Ala Val Ile Trp Tyr Asp Gly Ser Lys Arg Tyr Tyr Ala Asp Ser Val
    50                  55                  60                  
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Phe
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
                85                  90                  95      
Ala Thr Asn Asp Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser
            100                 105                 110         
Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Cys Ser
        115                 120                 125             
Arg Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly Cys Leu Val Lys Asp
    130                 135                 140                 
Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr
145                 150                 155                 160 
Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr
                165                 170                 175     
Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Lys
            180                 185                 190         
Thr Tyr Thr Cys Asn Val Asp His Lys Pro Ser Asn Thr Lys Val Asp
        195                 200                 205             
Lys Arg Val Glu Ser Lys Tyr Gly Pro Pro Cys Pro Pro Cys Pro Ala
    210                 215                 220                 
Pro Glu Phe Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro
225                 230                 235                 240 
Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val
                245                 250                 255     
Val Asp Val Ser Gln Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val
            260                 265                 270         
Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln
        275                 280                 285             
Phe Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln
    290                 295                 300                 
Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly
305                 310                 315                 320 
Leu Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro
                325                 330                 335     
Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met Thr
            340                 345                 350         
Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser
        355                 360                 365             
Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr
    370                 375                 380                 
Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr
385                 390                 395                 400 
Ser Arg Leu Thr Val Asp Lys Ser Arg Trp Gln Glu Gly Asn Val Phe
                405                 410                 415     
Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys
            420                 425                 430         
Ser Leu Ser Leu Ser Leu Gly Lys Gly Gly Gly Gly Ser Gly Gly Gly
        435                 440                 445             
Ser Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly
    450                 455                 460                 
Arg Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Thr Ile Thr Thr
465                 470                 475                 480 
Ile Thr Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Gly Leu Glu Phe
                485                 490                 495     
Val Ala Ser His Ser Trp Thr Asp Asn Asn Pro Tyr Tyr Ala Asp Ser
            500                 505                 510         
Val Lys Gly Arg Phe Ile Ile Ser Arg Asp Asn Ser Lys Asn Arg Leu
        515                 520                 525             
Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr
    530                 535                 540                 
Cys Ala Ala Thr Ala Arg Arg Ser Phe Val Gly Arg Gln Trp Tyr Thr
545                 550                 555                 560 
Glu Ala Arg Gln Tyr Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val
                565                 570                 575     
Ser Ser
        


<210> 153
<211> 578
<212> PRT
<213> Artificial Sequence

<220> 
<223> AS02640-9GS-Opdivo heavy chain fusion sequence

<400> 153
Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg
 1               5                  10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Thr Ile Thr Thr Ile
            20                  25                  30          
Thr Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Gly Leu Glu Phe Val
        35                  40                  45              
Ala Ser His Ser Trp Thr Asp Asn Asn Pro Tyr Tyr Ala Asp Ser Val
    50                  55                  60                  
Lys Gly Arg Phe Ile Ile Ser Arg Asp Asn Ser Lys Asn Arg Leu Tyr
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
                85                  90                  95      
Ala Ala Thr Ala Arg Arg Ser Phe Val Gly Arg Gln Trp Tyr Thr Glu
            100                 105                 110         
Ala Arg Gln Tyr Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser
        115                 120                 125             
Ser Gly Gly Gly Gly Ser Gly Gly Gly Ser Gln Val Gln Leu Val Glu
    130                 135                 140                 
Ser Gly Gly Gly Val Val Gln Pro Gly Arg Ser Leu Arg Leu Asp Cys
145                 150                 155                 160 
Lys Ala Ser Gly Ile Thr Phe Ser Asn Ser Gly Met His Trp Val Arg
                165                 170                 175     
Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ala Val Ile Trp Tyr Asp
            180                 185                 190         
Gly Ser Lys Arg Tyr Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile
        195                 200                 205             
Ser Arg Asp Asn Ser Lys Asn Thr Leu Phe Leu Gln Met Asn Ser Leu
    210                 215                 220                 
Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Thr Asn Asp Asp Tyr
225                 230                 235                 240 
Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly
                245                 250                 255     
Pro Ser Val Phe Pro Leu Ala Pro Cys Ser Arg Ser Thr Ser Glu Ser
            260                 265                 270         
Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val
        275                 280                 285             
Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe
    290                 295                 300                 
Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val
305                 310                 315                 320 
Thr Val Pro Ser Ser Ser Leu Gly Thr Lys Thr Tyr Thr Cys Asn Val
                325                 330                 335     
Asp His Lys Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu Ser Lys
            340                 345                 350         
Tyr Gly Pro Pro Cys Pro Pro Cys Pro Ala Pro Glu Phe Leu Gly Gly
        355                 360                 365             
Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile
    370                 375                 380                 
Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser Gln Glu
385                 390                 395                 400 
Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His
                405                 410                 415     
Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg
            420                 425                 430         
Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys
        435                 440                 445             
Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu
    450                 455                 460                 
Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr
465                 470                 475                 480 
Thr Leu Pro Pro Ser Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu
                485                 490                 495     
Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp
            500                 505                 510         
Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val
        515                 520                 525             
Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp
    530                 535                 540                 
Lys Ser Arg Trp Gln Glu Gly Asn Val Phe Ser Cys Ser Val Met His
545                 550                 555                 560 
Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu
                565                 570                 575     
Gly Lys
        


<210> 154
<211> 584
<212> PRT
<213> Artificial Sequence

<220> 
<223> Opdivo-hIgG1 hinge-AS02640 heavy chain fusion sequence

<400> 154
Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg
 1               5                  10                  15      
Ser Leu Arg Leu Asp Cys Lys Ala Ser Gly Ile Thr Phe Ser Asn Ser
            20                  25                  30          
Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
        35                  40                  45              
Ala Val Ile Trp Tyr Asp Gly Ser Lys Arg Tyr Tyr Ala Asp Ser Val
    50                  55                  60                  
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Phe
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
                85                  90                  95      
Ala Thr Asn Asp Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser
            100                 105                 110         
Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Cys Ser
        115                 120                 125             
Arg Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly Cys Leu Val Lys Asp
    130                 135                 140                 
Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr
145                 150                 155                 160 
Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr
                165                 170                 175     
Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Lys
            180                 185                 190         
Thr Tyr Thr Cys Asn Val Asp His Lys Pro Ser Asn Thr Lys Val Asp
        195                 200                 205             
Lys Arg Val Glu Ser Lys Tyr Gly Pro Pro Cys Pro Pro Cys Pro Ala
    210                 215                 220                 
Pro Glu Phe Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro
225                 230                 235                 240 
Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val
                245                 250                 255     
Val Asp Val Ser Gln Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val
            260                 265                 270         
Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln
        275                 280                 285             
Phe Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln
    290                 295                 300                 
Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly
305                 310                 315                 320 
Leu Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro
                325                 330                 335     
Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met Thr
            340                 345                 350         
Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser
        355                 360                 365             
Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr
    370                 375                 380                 
Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr
385                 390                 395                 400 
Ser Arg Leu Thr Val Asp Lys Ser Arg Trp Gln Glu Gly Asn Val Phe
                405                 410                 415     
Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys
            420                 425                 430         
Ser Leu Ser Leu Ser Leu Gly Lys Glu Pro Lys Ser Cys Asp Lys Thr
        435                 440                 445             
His Thr Cys Pro Pro Cys Pro Gln Val Gln Leu Val Glu Ser Gly Gly
    450                 455                 460                 
Gly Val Val Gln Pro Gly Arg Ser Leu Arg Leu Ser Cys Ala Ala Ser
465                 470                 475                 480 
Gly Arg Thr Ile Thr Thr Ile Thr Met Gly Trp Phe Arg Gln Ala Pro
                485                 490                 495     
Gly Lys Gly Leu Glu Phe Val Ala Ser His Ser Trp Thr Asp Asn Asn
            500                 505                 510         
Pro Tyr Tyr Ala Asp Ser Val Lys Gly Arg Phe Ile Ile Ser Arg Asp
        515                 520                 525             
Asn Ser Lys Asn Arg Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu
    530                 535                 540                 
Asp Thr Ala Val Tyr Tyr Cys Ala Ala Thr Ala Arg Arg Ser Phe Val
545                 550                 555                 560 
Gly Arg Gln Trp Tyr Thr Glu Ala Arg Gln Tyr Asp Tyr Trp Gly Gln
                565                 570                 575     
Gly Thr Leu Val Thr Val Ser Ser
            580                 


<210> 155
<211> 584
<212> PRT
<213> Artificial Sequence

<220> 
<223> AS02640-hIgG1 hinge-Opdivo heavy chain fusion sequence

<400> 155
Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg
 1               5                  10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Thr Ile Thr Thr Ile
            20                  25                  30          
Thr Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Gly Leu Glu Phe Val
        35                  40                  45              
Ala Ser His Ser Trp Thr Asp Asn Asn Pro Tyr Tyr Ala Asp Ser Val
    50                  55                  60                  
Lys Gly Arg Phe Ile Ile Ser Arg Asp Asn Ser Lys Asn Arg Leu Tyr
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
                85                  90                  95      
Ala Ala Thr Ala Arg Arg Ser Phe Val Gly Arg Gln Trp Tyr Thr Glu
            100                 105                 110         
Ala Arg Gln Tyr Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser
        115                 120                 125             
Ser Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro
    130                 135                 140                 
Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg
145                 150                 155                 160 
Ser Leu Arg Leu Asp Cys Lys Ala Ser Gly Ile Thr Phe Ser Asn Ser
                165                 170                 175     
Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
            180                 185                 190         
Ala Val Ile Trp Tyr Asp Gly Ser Lys Arg Tyr Tyr Ala Asp Ser Val
        195                 200                 205             
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Phe
    210                 215                 220                 
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
225                 230                 235                 240 
Ala Thr Asn Asp Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser
                245                 250                 255     
Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Cys Ser
            260                 265                 270         
Arg Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly Cys Leu Val Lys Asp
        275                 280                 285             
Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr
    290                 295                 300                 
Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr
305                 310                 315                 320 
Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Lys
                325                 330                 335     
Thr Tyr Thr Cys Asn Val Asp His Lys Pro Ser Asn Thr Lys Val Asp
            340                 345                 350         
Lys Arg Val Glu Ser Lys Tyr Gly Pro Pro Cys Pro Pro Cys Pro Ala
        355                 360                 365             
Pro Glu Phe Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro
    370                 375                 380                 
Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val
385                 390                 395                 400 
Val Asp Val Ser Gln Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val
                405                 410                 415     
Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln
            420                 425                 430         
Phe Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln
        435                 440                 445             
Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly
    450                 455                 460                 
Leu Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro
465                 470                 475                 480 
Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met Thr
                485                 490                 495     
Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser
            500                 505                 510         
Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr
        515                 520                 525             
Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr
    530                 535                 540                 
Ser Arg Leu Thr Val Asp Lys Ser Arg Trp Gln Glu Gly Asn Val Phe
545                 550                 555                 560 
Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys
                565                 570                 575     
Ser Leu Ser Leu Ser Leu Gly Lys
            580                 


<210> 156
<211> 569
<212> PRT
<213> Artificial Sequence

<220> 
<223> Opdivo-AS02640 heavy chain fusion sequence

<400> 156
Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg
 1               5                  10                  15      
Ser Leu Arg Leu Asp Cys Lys Ala Ser Gly Ile Thr Phe Ser Asn Ser
            20                  25                  30          
Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
        35                  40                  45              
Ala Val Ile Trp Tyr Asp Gly Ser Lys Arg Tyr Tyr Ala Asp Ser Val
    50                  55                  60                  
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Phe
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
                85                  90                  95      
Ala Thr Asn Asp Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser
            100                 105                 110         
Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Cys Ser
        115                 120                 125             
Arg Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly Cys Leu Val Lys Asp
    130                 135                 140                 
Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr
145                 150                 155                 160 
Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr
                165                 170                 175     
Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Lys
            180                 185                 190         
Thr Tyr Thr Cys Asn Val Asp His Lys Pro Ser Asn Thr Lys Val Asp
        195                 200                 205             
Lys Arg Val Glu Ser Lys Tyr Gly Pro Pro Cys Pro Pro Cys Pro Ala
    210                 215                 220                 
Pro Glu Phe Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro
225                 230                 235                 240 
Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val
                245                 250                 255     
Val Asp Val Ser Gln Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val
            260                 265                 270         
Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln
        275                 280                 285             
Phe Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln
    290                 295                 300                 
Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly
305                 310                 315                 320 
Leu Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro
                325                 330                 335     
Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met Thr
            340                 345                 350         
Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser
        355                 360                 365             
Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr
    370                 375                 380                 
Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr
385                 390                 395                 400 
Ser Arg Leu Thr Val Asp Lys Ser Arg Trp Gln Glu Gly Asn Val Phe
                405                 410                 415     
Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys
            420                 425                 430         
Ser Leu Ser Leu Ser Leu Gly Lys Gln Val Gln Leu Val Glu Ser Gly
        435                 440                 445             
Gly Gly Val Val Gln Pro Gly Arg Ser Leu Arg Leu Ser Cys Ala Ala
    450                 455                 460                 
Ser Gly Arg Thr Ile Thr Thr Ile Thr Met Gly Trp Phe Arg Gln Ala
465                 470                 475                 480 
Pro Gly Lys Gly Leu Glu Phe Val Ala Ser His Ser Trp Thr Asp Asn
                485                 490                 495     
Asn Pro Tyr Tyr Ala Asp Ser Val Lys Gly Arg Phe Ile Ile Ser Arg
            500                 505                 510         
Asp Asn Ser Lys Asn Arg Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala
        515                 520                 525             
Glu Asp Thr Ala Val Tyr Tyr Cys Ala Ala Thr Ala Arg Arg Ser Phe
    530                 535                 540                 
Val Gly Arg Gln Trp Tyr Thr Glu Ala Arg Gln Tyr Asp Tyr Trp Gly
545                 550                 555                 560 
Gln Gly Thr Leu Val Thr Val Ser Ser
                565                 


<210> 157
<211> 569
<212> PRT
<213> Artificial Sequence

<220> 
<223> AS02640-Opdivo heavy chain fusion sequence

<400> 157
Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg
 1               5                  10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Thr Ile Thr Thr Ile
            20                  25                  30          
Thr Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Gly Leu Glu Phe Val
        35                  40                  45              
Ala Ser His Ser Trp Thr Asp Asn Asn Pro Tyr Tyr Ala Asp Ser Val
    50                  55                  60                  
Lys Gly Arg Phe Ile Ile Ser Arg Asp Asn Ser Lys Asn Arg Leu Tyr
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
                85                  90                  95      
Ala Ala Thr Ala Arg Arg Ser Phe Val Gly Arg Gln Trp Tyr Thr Glu
            100                 105                 110         
Ala Arg Gln Tyr Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser
        115                 120                 125             
Ser Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly
    130                 135                 140                 
Arg Ser Leu Arg Leu Asp Cys Lys Ala Ser Gly Ile Thr Phe Ser Asn
145                 150                 155                 160 
Ser Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp
                165                 170                 175     
Val Ala Val Ile Trp Tyr Asp Gly Ser Lys Arg Tyr Tyr Ala Asp Ser
            180                 185                 190         
Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu
        195                 200                 205             
Phe Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr
    210                 215                 220                 
Cys Ala Thr Asn Asp Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val
225                 230                 235                 240 
Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Cys
                245                 250                 255     
Ser Arg Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly Cys Leu Val Lys
            260                 265                 270         
Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu
        275                 280                 285             
Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu
    290                 295                 300                 
Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr
305                 310                 315                 320 
Lys Thr Tyr Thr Cys Asn Val Asp His Lys Pro Ser Asn Thr Lys Val
                325                 330                 335     
Asp Lys Arg Val Glu Ser Lys Tyr Gly Pro Pro Cys Pro Pro Cys Pro
            340                 345                 350         
Ala Pro Glu Phe Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys
        355                 360                 365             
Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val
    370                 375                 380                 
Val Val Asp Val Ser Gln Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr
385                 390                 395                 400 
Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu
                405                 410                 415     
Gln Phe Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His
            420                 425                 430         
Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys
        435                 440                 445             
Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln
    450                 455                 460                 
Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met
465                 470                 475                 480 
Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro
                485                 490                 495     
Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn
            500                 505                 510         
Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu
        515                 520                 525             
Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg Trp Gln Glu Gly Asn Val
    530                 535                 540                 
Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln
545                 550                 555                 560 
Lys Ser Leu Ser Leu Ser Leu Gly Lys
                565                 


<210> 158
<211> 447
<212> PRT
<213> Artificial Sequence

<220> 
<223> Keytruda heavy chain

<400> 158
Gln Val Gln Leu Val Gln Ser Gly Val Glu Val Lys Lys Pro Gly Ala
 1               5                  10                  15      
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asn Tyr
            20                  25                  30          
Tyr Met Tyr Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met
        35                  40                  45              
Gly Gly Ile Asn Pro Ser Asn Gly Gly Thr Asn Phe Asn Glu Lys Phe
    50                  55                  60                  
Lys Asn Arg Val Thr Leu Thr Thr Asp Ser Ser Thr Thr Thr Ala Tyr
65                  70                  75                  80  
Met Glu Leu Lys Ser Leu Gln Phe Asp Asp Thr Ala Val Tyr Tyr Cys
                85                  90                  95      
Ala Arg Arg Asp Tyr Arg Phe Asp Met Gly Phe Asp Tyr Trp Gly Gln
            100                 105                 110         
Gly Thr Thr Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val
        115                 120                 125             
Phe Pro Leu Ala Pro Cys Ser Arg Ser Thr Ser Glu Ser Thr Ala Ala
    130                 135                 140                 
Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser
145                 150                 155                 160 
Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val
                165                 170                 175     
Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro
            180                 185                 190         
Ser Ser Ser Leu Gly Thr Lys Thr Tyr Thr Cys Asn Val Asp His Lys
        195                 200                 205             
Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu Ser Lys Tyr Gly Pro
    210                 215                 220                 
Pro Cys Pro Pro Cys Pro Ala Pro Glu Phe Leu Gly Gly Pro Ser Val
225                 230                 235                 240 
Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr
                245                 250                 255     
Pro Glu Val Thr Cys Val Val Val Asp Val Ser Gln Glu Asp Pro Glu
            260                 265                 270         
Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys
        275                 280                 285             
Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser
    290                 295                 300                 
Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys
305                 310                 315                 320 
Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile
                325                 330                 335     
Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro
            340                 345                 350         
Pro Ser Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu
        355                 360                 365             
Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn
    370                 375                 380                 
Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser
385                 390                 395                 400 
Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg
                405                 410                 415     
Trp Gln Glu Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu
            420                 425                 430         
His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly Lys
        435                 440                 445         


<210> 159
<211> 218
<212> PRT
<213> Artificial Sequence

<220> 
<223> Light chain amino acid sequence

<400> 159
Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly
 1               5                  10                  15      
Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Lys Gly Val Ser Thr Ser
            20                  25                  30          
Gly Tyr Ser Tyr Leu His Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro
        35                  40                  45              
Arg Leu Leu Ile Tyr Leu Ala Ser Tyr Leu Glu Ser Gly Val Pro Ala
    50                  55                  60                  
Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser
65                  70                  75                  80  
Ser Leu Glu Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln His Ser Arg
                85                  90                  95      
Asp Leu Pro Leu Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg
            100                 105                 110         
Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln
        115                 120                 125             
Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr
    130                 135                 140                 
Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser
145                 150                 155                 160 
Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr
                165                 170                 175     
Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys
            180                 185                 190         
His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro
        195                 200                 205             
Val Thr Lys Ser Phe Asn Arg Gly Glu Cys
    210                 215             


<210> 160
<211> 440
<212> PRT
<213> Artificial Sequence

<220> 
<223> Opdivo heavy chain 

<400> 160
Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg
 1               5                  10                  15      
Ser Leu Arg Leu Asp Cys Lys Ala Ser Gly Ile Thr Phe Ser Asn Ser
            20                  25                  30          
Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
        35                  40                  45              
Ala Val Ile Trp Tyr Asp Gly Ser Lys Arg Tyr Tyr Ala Asp Ser Val
    50                  55                  60                  
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Phe
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
                85                  90                  95      
Ala Thr Asn Asp Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser
            100                 105                 110         
Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Cys Ser
        115                 120                 125             
Arg Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly Cys Leu Val Lys Asp
    130                 135                 140                 
Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr
145                 150                 155                 160 
Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr
                165                 170                 175     
Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Lys
            180                 185                 190         
Thr Tyr Thr Cys Asn Val Asp His Lys Pro Ser Asn Thr Lys Val Asp
        195                 200                 205             
Lys Arg Val Glu Ser Lys Tyr Gly Pro Pro Cys Pro Pro Cys Pro Ala
    210                 215                 220                 
Pro Glu Phe Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro
225                 230                 235                 240 
Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val
                245                 250                 255     
Val Asp Val Ser Gln Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val
            260                 265                 270         
Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln
        275                 280                 285             
Phe Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln
    290                 295                 300                 
Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly
305                 310                 315                 320 
Leu Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro
                325                 330                 335     
Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met Thr
            340                 345                 350         
Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser
        355                 360                 365             
Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr
    370                 375                 380                 
Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr
385                 390                 395                 400 
Ser Arg Leu Thr Val Asp Lys Ser Arg Trp Gln Glu Gly Asn Val Phe
                405                 410                 415     
Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys
            420                 425                 430         
Ser Leu Ser Leu Ser Leu Gly Lys
        435                 440 


<210> 161
<211> 214
<212> PRT
<213> Artificial Sequence

<220> 
<223> Light chain amino acid sequence

<400> 161
Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly
 1               5                  10                  15      
Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Tyr
            20                  25                  30          
Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile
        35                  40                  45              
Tyr Asp Ala Ser Asn Arg Ala Thr Gly Ile Pro Ala Arg Phe Ser Gly
    50                  55                  60                  
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu Pro
65                  70                  75                  80  
Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Ser Ser Asn Trp Pro Arg
                85                  90                  95      
Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala Ala
            100                 105                 110         
Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly
        115                 120                 125             
Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala
    130                 135                 140                 
Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln
145                 150                 155                 160 
Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser
                165                 170                 175     
Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr
            180                 185                 190         
Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser
        195                 200                 205             
Phe Asn Arg Gly Glu Cys
    210                 


<210> 162
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> Linker peptide

<400> 162
Gly Gly Gly Gly Ser Gly Gly Gly Ser
 1               5                  


<210> 163
<211> 15
<212> PRT
<213> Artificial Sequence

<220> 
<223> IgG1 hinge

<400> 163
Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro
 1               5                  10                  15  


<210> 164
<211> 125
<212> PRT
<213> Homo sapiens

<400> 164
Ala Met His Val Ala Gln Pro Ala Val Val Leu Ala Ser Ser Arg Gly
 1               5                  10                  15      
Ile Ala Ser Phe Val Cys Glu Tyr Ala Ser Pro Gly Lys Ala Thr Glu
            20                  25                  30          
Val Arg Val Thr Val Leu Arg Gln Ala Asp Ser Gln Val Thr Glu Val
        35                  40                  45              
Cys Ala Ala Thr Tyr Met Met Gly Asn Glu Leu Thr Phe Leu Asp Asp
    50                  55                  60                  
Ser Ile Cys Thr Gly Thr Ser Ser Gly Asn Gln Val Asn Leu Thr Ile
65                  70                  75                  80  
Gln Gly Leu Arg Ala Met Asp Thr Gly Leu Tyr Ile Cys Lys Val Glu
                85                  90                  95      
Leu Met Tyr Pro Pro Pro Tyr Tyr Leu Gly Ile Gly Asn Gly Thr Gln
            100                 105                 110         
Ile Tyr Val Ile Asp Pro Glu Pro Cys Pro Asp Ser Asp
        115                 120                 125 


<210> 165
<211> 11
<212> PRT
<213> Artificial Sequence

<220> 
<223> A34310/A34311/A34313/A34625/A36566/A37067/
AS07392/AS07678/AS07712 FR4

<400> 165
Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser
 1               5                  10      


<210> 166
<211> 11
<212> PRT
<213> Artificial Sequence

<220> 
<223> A36922 FR4

<400> 166
Trp Gly Gln Gly Thr Gln Val Thr Ile Ser Thr
 1               5                  10      


<210> 167
<211> 11
<212> PRT
<213> Artificial Sequence

<220> 
<223> AS07014/AS07832 FR4

<400> 167
Trp Ala Gln Gly Thr Gln Val Thr Val Ser Ser
 1               5                  10      


<210> 168
<211> 11
<212> PRT
<213> Artificial Sequence

<220> 
<223> AS07172 FR4

<400> 168
Arg Gly Gln Gly Thr Gln Val Thr Val Ser Ser
 1               5                  10      


<210> 169
<211> 11
<212> PRT
<213> Artificial Sequence

<220> 
<223> AS07189/AS07688 FR4

<400> 169
Trp Gly Gln Gly Thr Gln Val Ile Val Ser Ser
 1               5                  10      


<210> 170
<211> 11
<212> PRT
<213> Artificial Sequence

<220> 
<223> AS07745 FR4

<400> 170
Gly Gly Gln Gly Thr Gln Val Thr Val Ser Ser
 1               5                  10      


<210> 171
<211> 586
<212> PRT
<213> Artificial Sequence

<220> 
<223> Tecentriq-9GS-A34311 heavy chain fusion sequence

<400> 171
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
 1               5                  10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp Ser
            20                  25                  30          
Trp Ile His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
        35                  40                  45              
Ala Trp Ile Ser Pro Tyr Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val
    50                  55                  60                  
Lys Gly Arg Phe Thr Ile Ser Ala Asp Thr Ser Lys Asn Thr Ala Tyr
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
                85                  90                  95      
Ala Arg Arg His Trp Pro Gly Gly Phe Asp Tyr Trp Gly Gln Gly Thr
            100                 105                 110         
Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro
        115                 120                 125             
Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly
    130                 135                 140                 
Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn
145                 150                 155                 160 
Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln
                165                 170                 175     
Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser
            180                 185                 190         
Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser
        195                 200                 205             
Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr
    210                 215                 220                 
His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser
225                 230                 235                 240 
Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg
                245                 250                 255     
Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro
            260                 265                 270         
Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala
        275                 280                 285             
Lys Thr Lys Pro Arg Glu Glu Gln Tyr Ala Ser Thr Tyr Arg Val Val
    290                 295                 300                 
Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr
305                 310                 315                 320 
Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr
                325                 330                 335     
Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu
            340                 345                 350         
Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys
        355                 360                 365             
Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser
    370                 375                 380                 
Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp
385                 390                 395                 400 
Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser
                405                 410                 415     
Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala
            420                 425                 430         
Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys
        435                 440                 445             
Gly Gly Gly Gly Ser Gly Gly Gly Ser Gln Val Lys Leu Glu Glu Ser
    450                 455                 460                 
Gly Gly Gly Leu Val Leu Pro Gly Glu Ser Leu Arg Leu Ser Cys Glu
465                 470                 475                 480 
Ala Ser Gly Arg Thr Ile Thr Thr Ile Thr Met Gly Trp Phe Arg Gln
                485                 490                 495     
Ala Pro Gly Lys Glu Arg Gln Phe Val Ala Ser His Ser Trp Thr Asp
            500                 505                 510         
Asn Asn Pro Tyr Tyr Ala Asp Ser Val Lys Gly Arg Phe Ile Ile Ser
        515                 520                 525             
Arg Asp Asn Ala Gly Asn Arg Val Tyr Leu Gln Met His Ser Leu Glu
    530                 535                 540                 
Pro Glu Asp Thr Ala Val Tyr Tyr Cys Ala Ala Thr Ala Arg Arg Ser
545                 550                 555                 560 
Phe Val Gly Arg Gln Trp Tyr Thr Glu Ala Arg Gln Tyr Asp Tyr Trp
                565                 570                 575     
Gly Gln Gly Thr Gln Val Thr Val Ser Ser
            580                 585     


<210> 172
<211> 586
<212> PRT
<213> Artificial Sequence

<220> 
<223> A34311-9GS-Tecentriq heavy chain fusion sequence

<400> 172
Gln Val Lys Leu Glu Glu Ser Gly Gly Gly Leu Val Leu Pro Gly Glu
 1               5                  10                  15      
Ser Leu Arg Leu Ser Cys Glu Ala Ser Gly Arg Thr Ile Thr Thr Ile
            20                  25                  30          
Thr Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Gln Phe Val
        35                  40                  45              
Ala Ser His Ser Trp Thr Asp Asn Asn Pro Tyr Tyr Ala Asp Ser Val
    50                  55                  60                  
Lys Gly Arg Phe Ile Ile Ser Arg Asp Asn Ala Gly Asn Arg Val Tyr
65                  70                  75                  80  
Leu Gln Met His Ser Leu Glu Pro Glu Asp Thr Ala Val Tyr Tyr Cys
                85                  90                  95      
Ala Ala Thr Ala Arg Arg Ser Phe Val Gly Arg Gln Trp Tyr Thr Glu
            100                 105                 110         
Ala Arg Gln Tyr Asp Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser
        115                 120                 125             
Ser Gly Gly Gly Gly Ser Gly Gly Gly Ser Glu Val Gln Leu Val Glu
    130                 135                 140                 
Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys
145                 150                 155                 160 
Ala Ala Ser Gly Phe Thr Phe Ser Asp Ser Trp Ile His Trp Val Arg
                165                 170                 175     
Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ala Trp Ile Ser Pro Tyr
            180                 185                 190         
Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile
        195                 200                 205             
Ser Ala Asp Thr Ser Lys Asn Thr Ala Tyr Leu Gln Met Asn Ser Leu
    210                 215                 220                 
Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg Arg His Trp Pro
225                 230                 235                 240 
Gly Gly Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser
                245                 250                 255     
Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys
            260                 265                 270         
Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr
        275                 280                 285             
Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser
    290                 295                 300                 
Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser
305                 310                 315                 320 
Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr
                325                 330                 335     
Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys
            340                 345                 350         
Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys
        355                 360                 365             
Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro
    370                 375                 380                 
Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys
385                 390                 395                 400 
Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp
                405                 410                 415     
Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu
            420                 425                 430         
Glu Gln Tyr Ala Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu
        435                 440                 445             
His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn
    450                 455                 460                 
Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly
465                 470                 475                 480 
Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu
                485                 490                 495     
Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr
            500                 505                 510         
Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn
        515                 520                 525             
Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe
    530                 535                 540                 
Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn
545                 550                 555                 560 
Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr
                565                 570                 575     
Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys
            580                 585     


<210> 173
<211> 592
<212> PRT
<213> Artificial Sequence

<220> 
<223> Tecentriq-hIgG1 hinge-A34311 heavy chain fusion sequence

<400> 173
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
 1               5                  10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp Ser
            20                  25                  30          
Trp Ile His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
        35                  40                  45              
Ala Trp Ile Ser Pro Tyr Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val
    50                  55                  60                  
Lys Gly Arg Phe Thr Ile Ser Ala Asp Thr Ser Lys Asn Thr Ala Tyr
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
                85                  90                  95      
Ala Arg Arg His Trp Pro Gly Gly Phe Asp Tyr Trp Gly Gln Gly Thr
            100                 105                 110         
Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro
        115                 120                 125             
Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly
    130                 135                 140                 
Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn
145                 150                 155                 160 
Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln
                165                 170                 175     
Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser
            180                 185                 190         
Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser
        195                 200                 205             
Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr
    210                 215                 220                 
His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser
225                 230                 235                 240 
Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg
                245                 250                 255     
Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro
            260                 265                 270         
Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala
        275                 280                 285             
Lys Thr Lys Pro Arg Glu Glu Gln Tyr Ala Ser Thr Tyr Arg Val Val
    290                 295                 300                 
Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr
305                 310                 315                 320 
Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr
                325                 330                 335     
Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu
            340                 345                 350         
Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys
        355                 360                 365             
Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser
    370                 375                 380                 
Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp
385                 390                 395                 400 
Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser
                405                 410                 415     
Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala
            420                 425                 430         
Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys
        435                 440                 445             
Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Gln
    450                 455                 460                 
Val Lys Leu Glu Glu Ser Gly Gly Gly Leu Val Leu Pro Gly Glu Ser
465                 470                 475                 480 
Leu Arg Leu Ser Cys Glu Ala Ser Gly Arg Thr Ile Thr Thr Ile Thr
                485                 490                 495     
Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Gln Phe Val Ala
            500                 505                 510         
Ser His Ser Trp Thr Asp Asn Asn Pro Tyr Tyr Ala Asp Ser Val Lys
        515                 520                 525             
Gly Arg Phe Ile Ile Ser Arg Asp Asn Ala Gly Asn Arg Val Tyr Leu
    530                 535                 540                 
Gln Met His Ser Leu Glu Pro Glu Asp Thr Ala Val Tyr Tyr Cys Ala
545                 550                 555                 560 
Ala Thr Ala Arg Arg Ser Phe Val Gly Arg Gln Trp Tyr Thr Glu Ala
                565                 570                 575     
Arg Gln Tyr Asp Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser
            580                 585                 590         


<210> 174
<211> 592
<212> PRT
<213> Artificial Sequence

<220> 
<223> A34311-hIgG1 hinge-Tecentriq heavy chain fusion sequence

<400> 174
Gln Val Lys Leu Glu Glu Ser Gly Gly Gly Leu Val Leu Pro Gly Glu
 1               5                  10                  15      
Ser Leu Arg Leu Ser Cys Glu Ala Ser Gly Arg Thr Ile Thr Thr Ile
            20                  25                  30          
Thr Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Gln Phe Val
        35                  40                  45              
Ala Ser His Ser Trp Thr Asp Asn Asn Pro Tyr Tyr Ala Asp Ser Val
    50                  55                  60                  
Lys Gly Arg Phe Ile Ile Ser Arg Asp Asn Ala Gly Asn Arg Val Tyr
65                  70                  75                  80  
Leu Gln Met His Ser Leu Glu Pro Glu Asp Thr Ala Val Tyr Tyr Cys
                85                  90                  95      
Ala Ala Thr Ala Arg Arg Ser Phe Val Gly Arg Gln Trp Tyr Thr Glu
            100                 105                 110         
Ala Arg Gln Tyr Asp Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser
        115                 120                 125             
Ser Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro
    130                 135                 140                 
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
145                 150                 155                 160 
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp Ser
                165                 170                 175     
Trp Ile His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
            180                 185                 190         
Ala Trp Ile Ser Pro Tyr Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val
        195                 200                 205             
Lys Gly Arg Phe Thr Ile Ser Ala Asp Thr Ser Lys Asn Thr Ala Tyr
    210                 215                 220                 
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
225                 230                 235                 240 
Ala Arg Arg His Trp Pro Gly Gly Phe Asp Tyr Trp Gly Gln Gly Thr
                245                 250                 255     
Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro
            260                 265                 270         
Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly
        275                 280                 285             
Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn
    290                 295                 300                 
Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln
305                 310                 315                 320 
Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser
                325                 330                 335     
Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser
            340                 345                 350         
Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr
        355                 360                 365             
His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser
    370                 375                 380                 
Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg
385                 390                 395                 400 
Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro
                405                 410                 415     
Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala
            420                 425                 430         
Lys Thr Lys Pro Arg Glu Glu Gln Tyr Ala Ser Thr Tyr Arg Val Val
        435                 440                 445             
Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr
    450                 455                 460                 
Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr
465                 470                 475                 480 
Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu
                485                 490                 495     
Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys
            500                 505                 510         
Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser
        515                 520                 525             
Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp
    530                 535                 540                 
Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser
545                 550                 555                 560 
Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala
                565                 570                 575     
Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys
            580                 585                 590         


<210> 175
<211> 577
<212> PRT
<213> Artificial Sequence

<220> 
<223> Tecentriq-A34311 heavy chain fusion sequence

<400> 175
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
 1               5                  10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp Ser
            20                  25                  30          
Trp Ile His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
        35                  40                  45              
Ala Trp Ile Ser Pro Tyr Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val
    50                  55                  60                  
Lys Gly Arg Phe Thr Ile Ser Ala Asp Thr Ser Lys Asn Thr Ala Tyr
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
                85                  90                  95      
Ala Arg Arg His Trp Pro Gly Gly Phe Asp Tyr Trp Gly Gln Gly Thr
            100                 105                 110         
Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro
        115                 120                 125             
Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly
    130                 135                 140                 
Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn
145                 150                 155                 160 
Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln
                165                 170                 175     
Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser
            180                 185                 190         
Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser
        195                 200                 205             
Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr
    210                 215                 220                 
His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser
225                 230                 235                 240 
Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg
                245                 250                 255     
Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro
            260                 265                 270         
Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala
        275                 280                 285             
Lys Thr Lys Pro Arg Glu Glu Gln Tyr Ala Ser Thr Tyr Arg Val Val
    290                 295                 300                 
Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr
305                 310                 315                 320 
Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr
                325                 330                 335     
Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu
            340                 345                 350         
Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys
        355                 360                 365             
Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser
    370                 375                 380                 
Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp
385                 390                 395                 400 
Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser
                405                 410                 415     
Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala
            420                 425                 430         
Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys
        435                 440                 445             
Gln Val Lys Leu Glu Glu Ser Gly Gly Gly Leu Val Leu Pro Gly Glu
    450                 455                 460                 
Ser Leu Arg Leu Ser Cys Glu Ala Ser Gly Arg Thr Ile Thr Thr Ile
465                 470                 475                 480 
Thr Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Gln Phe Val
                485                 490                 495     
Ala Ser His Ser Trp Thr Asp Asn Asn Pro Tyr Tyr Ala Asp Ser Val
            500                 505                 510         
Lys Gly Arg Phe Ile Ile Ser Arg Asp Asn Ala Gly Asn Arg Val Tyr
        515                 520                 525             
Leu Gln Met His Ser Leu Glu Pro Glu Asp Thr Ala Val Tyr Tyr Cys
    530                 535                 540                 
Ala Ala Thr Ala Arg Arg Ser Phe Val Gly Arg Gln Trp Tyr Thr Glu
545                 550                 555                 560 
Ala Arg Gln Tyr Asp Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser
                565                 570                 575     
Ser
    


<210> 176
<211> 577
<212> PRT
<213> Artificial Sequence

<220> 
<223> A34311-Tecentriq heavy chain fusion sequence

<400> 176
Gln Val Lys Leu Glu Glu Ser Gly Gly Gly Leu Val Leu Pro Gly Glu
 1               5                  10                  15      
Ser Leu Arg Leu Ser Cys Glu Ala Ser Gly Arg Thr Ile Thr Thr Ile
            20                  25                  30          
Thr Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Gln Phe Val
        35                  40                  45              
Ala Ser His Ser Trp Thr Asp Asn Asn Pro Tyr Tyr Ala Asp Ser Val
    50                  55                  60                  
Lys Gly Arg Phe Ile Ile Ser Arg Asp Asn Ala Gly Asn Arg Val Tyr
65                  70                  75                  80  
Leu Gln Met His Ser Leu Glu Pro Glu Asp Thr Ala Val Tyr Tyr Cys
                85                  90                  95      
Ala Ala Thr Ala Arg Arg Ser Phe Val Gly Arg Gln Trp Tyr Thr Glu
            100                 105                 110         
Ala Arg Gln Tyr Asp Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser
        115                 120                 125             
Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly
    130                 135                 140                 
Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp
145                 150                 155                 160 
Ser Trp Ile His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp
                165                 170                 175     
Val Ala Trp Ile Ser Pro Tyr Gly Gly Ser Thr Tyr Tyr Ala Asp Ser
            180                 185                 190         
Val Lys Gly Arg Phe Thr Ile Ser Ala Asp Thr Ser Lys Asn Thr Ala
        195                 200                 205             
Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr
    210                 215                 220                 
Cys Ala Arg Arg His Trp Pro Gly Gly Phe Asp Tyr Trp Gly Gln Gly
225                 230                 235                 240 
Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe
                245                 250                 255     
Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu
            260                 265                 270         
Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp
        275                 280                 285             
Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu
    290                 295                 300                 
Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser
305                 310                 315                 320 
Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro
                325                 330                 335     
Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys
            340                 345                 350         
Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro
        355                 360                 365             
Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser
    370                 375                 380                 
Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp
385                 390                 395                 400 
Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn
                405                 410                 415     
Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Ala Ser Thr Tyr Arg Val
            420                 425                 430         
Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu
        435                 440                 445             
Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys
    450                 455                 460                 
Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr
465                 470                 475                 480 
Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr
                485                 490                 495     
Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu
            500                 505                 510         
Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu
        515                 520                 525             
Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys
    530                 535                 540                 
Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu
545                 550                 555                 560 
Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly
                565                 570                 575     
Lys
    


<210> 177
<211> 586
<212> PRT
<213> Artificial Sequence

<220> 
<223> Tecentriq-9GS-AS02640 heavy chain fusion sequence

<400> 177
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
 1               5                  10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp Ser
            20                  25                  30          
Trp Ile His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
        35                  40                  45              
Ala Trp Ile Ser Pro Tyr Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val
    50                  55                  60                  
Lys Gly Arg Phe Thr Ile Ser Ala Asp Thr Ser Lys Asn Thr Ala Tyr
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
                85                  90                  95      
Ala Arg Arg His Trp Pro Gly Gly Phe Asp Tyr Trp Gly Gln Gly Thr
            100                 105                 110         
Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro
        115                 120                 125             
Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly
    130                 135                 140                 
Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn
145                 150                 155                 160 
Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln
                165                 170                 175     
Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser
            180                 185                 190         
Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser
        195                 200                 205             
Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr
    210                 215                 220                 
His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser
225                 230                 235                 240 
Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg
                245                 250                 255     
Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro
            260                 265                 270         
Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala
        275                 280                 285             
Lys Thr Lys Pro Arg Glu Glu Gln Tyr Ala Ser Thr Tyr Arg Val Val
    290                 295                 300                 
Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr
305                 310                 315                 320 
Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr
                325                 330                 335     
Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu
            340                 345                 350         
Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys
        355                 360                 365             
Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser
    370                 375                 380                 
Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp
385                 390                 395                 400 
Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser
                405                 410                 415     
Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala
            420                 425                 430         
Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys
        435                 440                 445             
Gly Gly Gly Gly Ser Gly Gly Gly Ser Gln Val Gln Leu Val Glu Ser
    450                 455                 460                 
Gly Gly Gly Val Val Gln Pro Gly Arg Ser Leu Arg Leu Ser Cys Ala
465                 470                 475                 480 
Ala Ser Gly Arg Thr Ile Thr Thr Ile Thr Met Gly Trp Phe Arg Gln
                485                 490                 495     
Ala Pro Gly Lys Gly Leu Glu Phe Val Ala Ser His Ser Trp Thr Asp
            500                 505                 510         
Asn Asn Pro Tyr Tyr Ala Asp Ser Val Lys Gly Arg Phe Ile Ile Ser
        515                 520                 525             
Arg Asp Asn Ser Lys Asn Arg Leu Tyr Leu Gln Met Asn Ser Leu Arg
    530                 535                 540                 
Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Ala Thr Ala Arg Arg Ser
545                 550                 555                 560 
Phe Val Gly Arg Gln Trp Tyr Thr Glu Ala Arg Gln Tyr Asp Tyr Trp
                565                 570                 575     
Gly Gln Gly Thr Leu Val Thr Val Ser Ser
            580                 585     


<210> 178
<211> 586
<212> PRT
<213> Artificial Sequence

<220> 
<223> AS02640-9GS-Tecentriq heavy chain fusion sequence

<400> 178
Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg
 1               5                  10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Thr Ile Thr Thr Ile
            20                  25                  30          
Thr Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Gly Leu Glu Phe Val
        35                  40                  45              
Ala Ser His Ser Trp Thr Asp Asn Asn Pro Tyr Tyr Ala Asp Ser Val
    50                  55                  60                  
Lys Gly Arg Phe Ile Ile Ser Arg Asp Asn Ser Lys Asn Arg Leu Tyr
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
                85                  90                  95      
Ala Ala Thr Ala Arg Arg Ser Phe Val Gly Arg Gln Trp Tyr Thr Glu
            100                 105                 110         
Ala Arg Gln Tyr Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser
        115                 120                 125             
Ser Gly Gly Gly Gly Ser Gly Gly Gly Ser Glu Val Gln Leu Val Glu
    130                 135                 140                 
Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys
145                 150                 155                 160 
Ala Ala Ser Gly Phe Thr Phe Ser Asp Ser Trp Ile His Trp Val Arg
                165                 170                 175     
Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ala Trp Ile Ser Pro Tyr
            180                 185                 190         
Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile
        195                 200                 205             
Ser Ala Asp Thr Ser Lys Asn Thr Ala Tyr Leu Gln Met Asn Ser Leu
    210                 215                 220                 
Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg Arg His Trp Pro
225                 230                 235                 240 
Gly Gly Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser
                245                 250                 255     
Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys
            260                 265                 270         
Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr
        275                 280                 285             
Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser
    290                 295                 300                 
Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser
305                 310                 315                 320 
Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr
                325                 330                 335     
Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys
            340                 345                 350         
Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys
        355                 360                 365             
Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro
    370                 375                 380                 
Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys
385                 390                 395                 400 
Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp
                405                 410                 415     
Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu
            420                 425                 430         
Glu Gln Tyr Ala Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu
        435                 440                 445             
His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn
    450                 455                 460                 
Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly
465                 470                 475                 480 
Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu
                485                 490                 495     
Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr
            500                 505                 510         
Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn
        515                 520                 525             
Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe
    530                 535                 540                 
Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn
545                 550                 555                 560 
Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr
                565                 570                 575     
Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys
            580                 585     


<210> 179
<211> 592
<212> PRT
<213> Artificial Sequence

<220> 
<223> Tecentriq-hIgG1 hinge-AS02640 heavy chain fusion sequence

<400> 179
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
 1               5                  10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp Ser
            20                  25                  30          
Trp Ile His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
        35                  40                  45              
Ala Trp Ile Ser Pro Tyr Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val
    50                  55                  60                  
Lys Gly Arg Phe Thr Ile Ser Ala Asp Thr Ser Lys Asn Thr Ala Tyr
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
                85                  90                  95      
Ala Arg Arg His Trp Pro Gly Gly Phe Asp Tyr Trp Gly Gln Gly Thr
            100                 105                 110         
Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro
        115                 120                 125             
Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly
    130                 135                 140                 
Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn
145                 150                 155                 160 
Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln
                165                 170                 175     
Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser
            180                 185                 190         
Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser
        195                 200                 205             
Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr
    210                 215                 220                 
His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser
225                 230                 235                 240 
Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg
                245                 250                 255     
Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro
            260                 265                 270         
Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala
        275                 280                 285             
Lys Thr Lys Pro Arg Glu Glu Gln Tyr Ala Ser Thr Tyr Arg Val Val
    290                 295                 300                 
Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr
305                 310                 315                 320 
Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr
                325                 330                 335     
Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu
            340                 345                 350         
Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys
        355                 360                 365             
Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser
    370                 375                 380                 
Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp
385                 390                 395                 400 
Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser
                405                 410                 415     
Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala
            420                 425                 430         
Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys
        435                 440                 445             
Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Gln
    450                 455                 460                 
Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg Ser
465                 470                 475                 480 
Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Thr Ile Thr Thr Ile Thr
                485                 490                 495     
Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Gly Leu Glu Phe Val Ala
            500                 505                 510         
Ser His Ser Trp Thr Asp Asn Asn Pro Tyr Tyr Ala Asp Ser Val Lys
        515                 520                 525             
Gly Arg Phe Ile Ile Ser Arg Asp Asn Ser Lys Asn Arg Leu Tyr Leu
    530                 535                 540                 
Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala
545                 550                 555                 560 
Ala Thr Ala Arg Arg Ser Phe Val Gly Arg Gln Trp Tyr Thr Glu Ala
                565                 570                 575     
Arg Gln Tyr Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser
            580                 585                 590         


<210> 180
<211> 592
<212> PRT
<213> Artificial Sequence

<220> 
<223> AS02640-hIgG1 hinge-Tecentriq heavy chain fusion sequence

<400> 180
Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg
 1               5                  10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Thr Ile Thr Thr Ile
            20                  25                  30          
Thr Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Gly Leu Glu Phe Val
        35                  40                  45              
Ala Ser His Ser Trp Thr Asp Asn Asn Pro Tyr Tyr Ala Asp Ser Val
    50                  55                  60                  
Lys Gly Arg Phe Ile Ile Ser Arg Asp Asn Ser Lys Asn Arg Leu Tyr
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
                85                  90                  95      
Ala Ala Thr Ala Arg Arg Ser Phe Val Gly Arg Gln Trp Tyr Thr Glu
            100                 105                 110         
Ala Arg Gln Tyr Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser
        115                 120                 125             
Ser Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro
    130                 135                 140                 
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
145                 150                 155                 160 
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp Ser
                165                 170                 175     
Trp Ile His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
            180                 185                 190         
Ala Trp Ile Ser Pro Tyr Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val
        195                 200                 205             
Lys Gly Arg Phe Thr Ile Ser Ala Asp Thr Ser Lys Asn Thr Ala Tyr
    210                 215                 220                 
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
225                 230                 235                 240 
Ala Arg Arg His Trp Pro Gly Gly Phe Asp Tyr Trp Gly Gln Gly Thr
                245                 250                 255     
Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro
            260                 265                 270         
Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly
        275                 280                 285             
Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn
    290                 295                 300                 
Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln
305                 310                 315                 320 
Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser
                325                 330                 335     
Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser
            340                 345                 350         
Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr
        355                 360                 365             
His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser
    370                 375                 380                 
Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg
385                 390                 395                 400 
Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro
                405                 410                 415     
Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala
            420                 425                 430         
Lys Thr Lys Pro Arg Glu Glu Gln Tyr Ala Ser Thr Tyr Arg Val Val
        435                 440                 445             
Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr
    450                 455                 460                 
Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr
465                 470                 475                 480 
Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu
                485                 490                 495     
Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys
            500                 505                 510         
Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser
        515                 520                 525             
Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp
    530                 535                 540                 
Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser
545                 550                 555                 560 
Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala
                565                 570                 575     
Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys
            580                 585                 590         


<210> 181
<211> 577
<212> PRT
<213> Artificial Sequence

<220> 
<223> Tecentriq-AS02640 heavy chain fusion sequence

<400> 181
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
 1               5                  10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp Ser
            20                  25                  30          
Trp Ile His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
        35                  40                  45              
Ala Trp Ile Ser Pro Tyr Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val
    50                  55                  60                  
Lys Gly Arg Phe Thr Ile Ser Ala Asp Thr Ser Lys Asn Thr Ala Tyr
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
                85                  90                  95      
Ala Arg Arg His Trp Pro Gly Gly Phe Asp Tyr Trp Gly Gln Gly Thr
            100                 105                 110         
Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro
        115                 120                 125             
Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly
    130                 135                 140                 
Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn
145                 150                 155                 160 
Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln
                165                 170                 175     
Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser
            180                 185                 190         
Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser
        195                 200                 205             
Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr
    210                 215                 220                 
His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser
225                 230                 235                 240 
Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg
                245                 250                 255     
Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro
            260                 265                 270         
Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala
        275                 280                 285             
Lys Thr Lys Pro Arg Glu Glu Gln Tyr Ala Ser Thr Tyr Arg Val Val
    290                 295                 300                 
Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr
305                 310                 315                 320 
Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr
                325                 330                 335     
Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu
            340                 345                 350         
Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys
        355                 360                 365             
Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser
    370                 375                 380                 
Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp
385                 390                 395                 400 
Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser
                405                 410                 415     
Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala
            420                 425                 430         
Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys
        435                 440                 445             
Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg
    450                 455                 460                 
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Thr Ile Thr Thr Ile
465                 470                 475                 480 
Thr Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Gly Leu Glu Phe Val
                485                 490                 495     
Ala Ser His Ser Trp Thr Asp Asn Asn Pro Tyr Tyr Ala Asp Ser Val
            500                 505                 510         
Lys Gly Arg Phe Ile Ile Ser Arg Asp Asn Ser Lys Asn Arg Leu Tyr
        515                 520                 525             
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
    530                 535                 540                 
Ala Ala Thr Ala Arg Arg Ser Phe Val Gly Arg Gln Trp Tyr Thr Glu
545                 550                 555                 560 
Ala Arg Gln Tyr Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser
                565                 570                 575     
Ser
    


<210> 182
<211> 577
<212> PRT
<213> Artificial Sequence

<220> 
<223> AS02640-Tecentriq heavy chain fusion sequence

<400> 182
Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg
 1               5                  10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Thr Ile Thr Thr Ile
            20                  25                  30          
Thr Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Gly Leu Glu Phe Val
        35                  40                  45              
Ala Ser His Ser Trp Thr Asp Asn Asn Pro Tyr Tyr Ala Asp Ser Val
    50                  55                  60                  
Lys Gly Arg Phe Ile Ile Ser Arg Asp Asn Ser Lys Asn Arg Leu Tyr
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
                85                  90                  95      
Ala Ala Thr Ala Arg Arg Ser Phe Val Gly Arg Gln Trp Tyr Thr Glu
            100                 105                 110         
Ala Arg Gln Tyr Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser
        115                 120                 125             
Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly
    130                 135                 140                 
Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp
145                 150                 155                 160 
Ser Trp Ile His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp
                165                 170                 175     
Val Ala Trp Ile Ser Pro Tyr Gly Gly Ser Thr Tyr Tyr Ala Asp Ser
            180                 185                 190         
Val Lys Gly Arg Phe Thr Ile Ser Ala Asp Thr Ser Lys Asn Thr Ala
        195                 200                 205             
Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr
    210                 215                 220                 
Cys Ala Arg Arg His Trp Pro Gly Gly Phe Asp Tyr Trp Gly Gln Gly
225                 230                 235                 240 
Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe
                245                 250                 255     
Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu
            260                 265                 270         
Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp
        275                 280                 285             
Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu
    290                 295                 300                 
Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser
305                 310                 315                 320 
Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro
                325                 330                 335     
Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys
            340                 345                 350         
Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro
        355                 360                 365             
Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser
    370                 375                 380                 
Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp
385                 390                 395                 400 
Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn
                405                 410                 415     
Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Ala Ser Thr Tyr Arg Val
            420                 425                 430         
Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu
        435                 440                 445             
Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys
    450                 455                 460                 
Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr
465                 470                 475                 480 
Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr
                485                 490                 495     
Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu
            500                 505                 510         
Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu
        515                 520                 525             
Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys
    530                 535                 540                 
Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu
545                 550                 555                 560 
Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly
                565                 570                 575     
Lys
    


<210> 183
<211> 589
<212> PRT
<213> Artificial Sequence

<220> 
<223> Durvalumab-9GS-A34311 heavy chain fusion sequence

<400> 183
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
 1               5                  10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Arg Tyr
            20                  25                  30          
Trp Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
        35                  40                  45              
Ala Asn Ile Lys Gln Asp Gly Ser Glu Lys Tyr Tyr Val Asp Ser Val
    50                  55                  60                  
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
                85                  90                  95      
Ala Arg Glu Gly Gly Trp Phe Gly Glu Leu Ala Phe Asp Tyr Trp Gly
            100                 105                 110         
Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser
        115                 120                 125             
Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala
    130                 135                 140                 
Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val
145                 150                 155                 160 
Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala
                165                 170                 175     
Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val
            180                 185                 190         
Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His
        195                 200                 205             
Lys Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu Pro Lys Ser Cys
    210                 215                 220                 
Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Phe Glu Gly
225                 230                 235                 240 
Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met
                245                 250                 255     
Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His
            260                 265                 270         
Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val
        275                 280                 285             
His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr
    290                 295                 300                 
Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly
305                 310                 315                 320 
Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Ser Ile
                325                 330                 335     
Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val
            340                 345                 350         
Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser
        355                 360                 365             
Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu
    370                 375                 380                 
Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro
385                 390                 395                 400 
Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val
                405                 410                 415     
Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met
            420                 425                 430         
His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser
        435                 440                 445             
Pro Gly Lys Gly Gly Gly Gly Ser Gly Gly Gly Ser Gln Val Lys Leu
    450                 455                 460                 
Glu Glu Ser Gly Gly Gly Leu Val Leu Pro Gly Glu Ser Leu Arg Leu
465                 470                 475                 480 
Ser Cys Glu Ala Ser Gly Arg Thr Ile Thr Thr Ile Thr Met Gly Trp
                485                 490                 495     
Phe Arg Gln Ala Pro Gly Lys Glu Arg Gln Phe Val Ala Ser His Ser
            500                 505                 510         
Trp Thr Asp Asn Asn Pro Tyr Tyr Ala Asp Ser Val Lys Gly Arg Phe
        515                 520                 525             
Ile Ile Ser Arg Asp Asn Ala Gly Asn Arg Val Tyr Leu Gln Met His
    530                 535                 540                 
Ser Leu Glu Pro Glu Asp Thr Ala Val Tyr Tyr Cys Ala Ala Thr Ala
545                 550                 555                 560 
Arg Arg Ser Phe Val Gly Arg Gln Trp Tyr Thr Glu Ala Arg Gln Tyr
                565                 570                 575     
Asp Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser
            580                 585                 


<210> 184
<211> 589
<212> PRT
<213> Artificial Sequence

<220> 
<223> A34311-9GS-Durvalumab heavy chain fusion sequence

<400> 184
Gln Val Lys Leu Glu Glu Ser Gly Gly Gly Leu Val Leu Pro Gly Glu
 1               5                  10                  15      
Ser Leu Arg Leu Ser Cys Glu Ala Ser Gly Arg Thr Ile Thr Thr Ile
            20                  25                  30          
Thr Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Gln Phe Val
        35                  40                  45              
Ala Ser His Ser Trp Thr Asp Asn Asn Pro Tyr Tyr Ala Asp Ser Val
    50                  55                  60                  
Lys Gly Arg Phe Ile Ile Ser Arg Asp Asn Ala Gly Asn Arg Val Tyr
65                  70                  75                  80  
Leu Gln Met His Ser Leu Glu Pro Glu Asp Thr Ala Val Tyr Tyr Cys
                85                  90                  95      
Ala Ala Thr Ala Arg Arg Ser Phe Val Gly Arg Gln Trp Tyr Thr Glu
            100                 105                 110         
Ala Arg Gln Tyr Asp Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser
        115                 120                 125             
Ser Gly Gly Gly Gly Ser Gly Gly Gly Ser Glu Val Gln Leu Val Glu
    130                 135                 140                 
Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys
145                 150                 155                 160 
Ala Ala Ser Gly Phe Thr Phe Ser Arg Tyr Trp Met Ser Trp Val Arg
                165                 170                 175     
Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ala Asn Ile Lys Gln Asp
            180                 185                 190         
Gly Ser Glu Lys Tyr Tyr Val Asp Ser Val Lys Gly Arg Phe Thr Ile
        195                 200                 205             
Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr Leu Gln Met Asn Ser Leu
    210                 215                 220                 
Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg Glu Gly Gly Trp
225                 230                 235                 240 
Phe Gly Glu Leu Ala Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr
                245                 250                 255     
Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro
            260                 265                 270         
Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val
        275                 280                 285             
Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala
    290                 295                 300                 
Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly
305                 310                 315                 320 
Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly
                325                 330                 335     
Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys
            340                 345                 350         
Val Asp Lys Arg Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys
        355                 360                 365             
Pro Pro Cys Pro Ala Pro Glu Phe Glu Gly Gly Pro Ser Val Phe Leu
    370                 375                 380                 
Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu
385                 390                 395                 400 
Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys
                405                 410                 415     
Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys
            420                 425                 430         
Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu
        435                 440                 445             
Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys
    450                 455                 460                 
Val Ser Asn Lys Ala Leu Pro Ala Ser Ile Glu Lys Thr Ile Ser Lys
465                 470                 475                 480 
Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser
                485                 490                 495     
Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys
            500                 505                 510         
Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln
        515                 520                 525             
Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly
    530                 535                 540                 
Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln
545                 550                 555                 560 
Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn
                565                 570                 575     
His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys
            580                 585                 


<210> 185
<211> 595
<212> PRT
<213> Artificial Sequence

<220> 
<223> Durvalumab-hIgG1 hinge-A34311 heavy chain fusion sequence

<400> 185
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
 1               5                  10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Arg Tyr
            20                  25                  30          
Trp Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
        35                  40                  45              
Ala Asn Ile Lys Gln Asp Gly Ser Glu Lys Tyr Tyr Val Asp Ser Val
    50                  55                  60                  
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
                85                  90                  95      
Ala Arg Glu Gly Gly Trp Phe Gly Glu Leu Ala Phe Asp Tyr Trp Gly
            100                 105                 110         
Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser
        115                 120                 125             
Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala
    130                 135                 140                 
Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val
145                 150                 155                 160 
Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala
                165                 170                 175     
Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val
            180                 185                 190         
Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His
        195                 200                 205             
Lys Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu Pro Lys Ser Cys
    210                 215                 220                 
Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Phe Glu Gly
225                 230                 235                 240 
Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met
                245                 250                 255     
Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His
            260                 265                 270         
Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val
        275                 280                 285             
His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr
    290                 295                 300                 
Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly
305                 310                 315                 320 
Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Ser Ile
                325                 330                 335     
Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val
            340                 345                 350         
Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser
        355                 360                 365             
Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu
    370                 375                 380                 
Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro
385                 390                 395                 400 
Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val
                405                 410                 415     
Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met
            420                 425                 430         
His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser
        435                 440                 445             
Pro Gly Lys Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro
    450                 455                 460                 
Cys Pro Gln Val Lys Leu Glu Glu Ser Gly Gly Gly Leu Val Leu Pro
465                 470                 475                 480 
Gly Glu Ser Leu Arg Leu Ser Cys Glu Ala Ser Gly Arg Thr Ile Thr
                485                 490                 495     
Thr Ile Thr Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Gln
            500                 505                 510         
Phe Val Ala Ser His Ser Trp Thr Asp Asn Asn Pro Tyr Tyr Ala Asp
        515                 520                 525             
Ser Val Lys Gly Arg Phe Ile Ile Ser Arg Asp Asn Ala Gly Asn Arg
    530                 535                 540                 
Val Tyr Leu Gln Met His Ser Leu Glu Pro Glu Asp Thr Ala Val Tyr
545                 550                 555                 560 
Tyr Cys Ala Ala Thr Ala Arg Arg Ser Phe Val Gly Arg Gln Trp Tyr
                565                 570                 575     
Thr Glu Ala Arg Gln Tyr Asp Tyr Trp Gly Gln Gly Thr Gln Val Thr
            580                 585                 590         
Val Ser Ser
        595 


<210> 186
<211> 595
<212> PRT
<213> Artificial Sequence

<220> 
<223> A34311-hIgG1 hinge-Durvalumab heavy chain fusion sequence

<400> 186
Gln Val Lys Leu Glu Glu Ser Gly Gly Gly Leu Val Leu Pro Gly Glu
 1               5                  10                  15      
Ser Leu Arg Leu Ser Cys Glu Ala Ser Gly Arg Thr Ile Thr Thr Ile
            20                  25                  30          
Thr Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Gln Phe Val
        35                  40                  45              
Ala Ser His Ser Trp Thr Asp Asn Asn Pro Tyr Tyr Ala Asp Ser Val
    50                  55                  60                  
Lys Gly Arg Phe Ile Ile Ser Arg Asp Asn Ala Gly Asn Arg Val Tyr
65                  70                  75                  80  
Leu Gln Met His Ser Leu Glu Pro Glu Asp Thr Ala Val Tyr Tyr Cys
                85                  90                  95      
Ala Ala Thr Ala Arg Arg Ser Phe Val Gly Arg Gln Trp Tyr Thr Glu
            100                 105                 110         
Ala Arg Gln Tyr Asp Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser
        115                 120                 125             
Ser Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro
    130                 135                 140                 
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
145                 150                 155                 160 
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Arg Tyr
                165                 170                 175     
Trp Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
            180                 185                 190         
Ala Asn Ile Lys Gln Asp Gly Ser Glu Lys Tyr Tyr Val Asp Ser Val
        195                 200                 205             
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr
    210                 215                 220                 
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
225                 230                 235                 240 
Ala Arg Glu Gly Gly Trp Phe Gly Glu Leu Ala Phe Asp Tyr Trp Gly
                245                 250                 255     
Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser
            260                 265                 270         
Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala
        275                 280                 285             
Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val
    290                 295                 300                 
Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala
305                 310                 315                 320 
Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val
                325                 330                 335     
Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His
            340                 345                 350         
Lys Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu Pro Lys Ser Cys
        355                 360                 365             
Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Phe Glu Gly
    370                 375                 380                 
Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met
385                 390                 395                 400 
Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His
                405                 410                 415     
Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val
            420                 425                 430         
His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr
        435                 440                 445             
Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly
    450                 455                 460                 
Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Ser Ile
465                 470                 475                 480 
Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val
                485                 490                 495     
Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser
            500                 505                 510         
Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu
        515                 520                 525             
Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro
    530                 535                 540                 
Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val
545                 550                 555                 560 
Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met
                565                 570                 575     
His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser
            580                 585                 590         
Pro Gly Lys
        595 


<210> 187
<211> 580
<212> PRT
<213> Artificial Sequence

<220> 
<223> Durvalumab-A34311 heavy chain fusion sequence

<400> 187
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
 1               5                  10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Arg Tyr
            20                  25                  30          
Trp Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
        35                  40                  45              
Ala Asn Ile Lys Gln Asp Gly Ser Glu Lys Tyr Tyr Val Asp Ser Val
    50                  55                  60                  
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
                85                  90                  95      
Ala Arg Glu Gly Gly Trp Phe Gly Glu Leu Ala Phe Asp Tyr Trp Gly
            100                 105                 110         
Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser
        115                 120                 125             
Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala
    130                 135                 140                 
Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val
145                 150                 155                 160 
Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala
                165                 170                 175     
Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val
            180                 185                 190         
Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His
        195                 200                 205             
Lys Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu Pro Lys Ser Cys
    210                 215                 220                 
Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Phe Glu Gly
225                 230                 235                 240 
Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met
                245                 250                 255     
Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His
            260                 265                 270         
Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val
        275                 280                 285             
His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr
    290                 295                 300                 
Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly
305                 310                 315                 320 
Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Ser Ile
                325                 330                 335     
Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val
            340                 345                 350         
Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser
        355                 360                 365             
Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu
    370                 375                 380                 
Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro
385                 390                 395                 400 
Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val
                405                 410                 415     
Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met
            420                 425                 430         
His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser
        435                 440                 445             
Pro Gly Lys Gln Val Lys Leu Glu Glu Ser Gly Gly Gly Leu Val Leu
    450                 455                 460                 
Pro Gly Glu Ser Leu Arg Leu Ser Cys Glu Ala Ser Gly Arg Thr Ile
465                 470                 475                 480 
Thr Thr Ile Thr Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg
                485                 490                 495     
Gln Phe Val Ala Ser His Ser Trp Thr Asp Asn Asn Pro Tyr Tyr Ala
            500                 505                 510         
Asp Ser Val Lys Gly Arg Phe Ile Ile Ser Arg Asp Asn Ala Gly Asn
        515                 520                 525             
Arg Val Tyr Leu Gln Met His Ser Leu Glu Pro Glu Asp Thr Ala Val
    530                 535                 540                 
Tyr Tyr Cys Ala Ala Thr Ala Arg Arg Ser Phe Val Gly Arg Gln Trp
545                 550                 555                 560 
Tyr Thr Glu Ala Arg Gln Tyr Asp Tyr Trp Gly Gln Gly Thr Gln Val
                565                 570                 575     
Thr Val Ser Ser
            580 


<210> 188
<211> 580
<212> PRT
<213> Artificial Sequence

<220> 
<223> A34311-Durvalumab heavy chain fusion sequence

<400> 188
Gln Val Lys Leu Glu Glu Ser Gly Gly Gly Leu Val Leu Pro Gly Glu
 1               5                  10                  15      
Ser Leu Arg Leu Ser Cys Glu Ala Ser Gly Arg Thr Ile Thr Thr Ile
            20                  25                  30          
Thr Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Gln Phe Val
        35                  40                  45              
Ala Ser His Ser Trp Thr Asp Asn Asn Pro Tyr Tyr Ala Asp Ser Val
    50                  55                  60                  
Lys Gly Arg Phe Ile Ile Ser Arg Asp Asn Ala Gly Asn Arg Val Tyr
65                  70                  75                  80  
Leu Gln Met His Ser Leu Glu Pro Glu Asp Thr Ala Val Tyr Tyr Cys
                85                  90                  95      
Ala Ala Thr Ala Arg Arg Ser Phe Val Gly Arg Gln Trp Tyr Thr Glu
            100                 105                 110         
Ala Arg Gln Tyr Asp Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser
        115                 120                 125             
Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly
    130                 135                 140                 
Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Arg
145                 150                 155                 160 
Tyr Trp Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp
                165                 170                 175     
Val Ala Asn Ile Lys Gln Asp Gly Ser Glu Lys Tyr Tyr Val Asp Ser
            180                 185                 190         
Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu
        195                 200                 205             
Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr
    210                 215                 220                 
Cys Ala Arg Glu Gly Gly Trp Phe Gly Glu Leu Ala Phe Asp Tyr Trp
225                 230                 235                 240 
Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro
                245                 250                 255     
Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr
            260                 265                 270         
Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr
        275                 280                 285             
Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro
    290                 295                 300                 
Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr
305                 310                 315                 320 
Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn
                325                 330                 335     
His Lys Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu Pro Lys Ser
            340                 345                 350         
Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Phe Glu
        355                 360                 365             
Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu
    370                 375                 380                 
Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser
385                 390                 395                 400 
His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu
                405                 410                 415     
Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr
            420                 425                 430         
Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn
        435                 440                 445             
Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Ser
    450                 455                 460                 
Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln
465                 470                 475                 480 
Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val
                485                 490                 495     
Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val
            500                 505                 510         
Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro
        515                 520                 525             
Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr
    530                 535                 540                 
Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val
545                 550                 555                 560 
Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu
                565                 570                 575     
Ser Pro Gly Lys
            580 


<210> 189
<211> 589
<212> PRT
<213> Artificial Sequence

<220> 
<223> Durvalumab-9GS-AS02640 heavy chain fusion sequence

<400> 189
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
 1               5                  10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Arg Tyr
            20                  25                  30          
Trp Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
        35                  40                  45              
Ala Asn Ile Lys Gln Asp Gly Ser Glu Lys Tyr Tyr Val Asp Ser Val
    50                  55                  60                  
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
                85                  90                  95      
Ala Arg Glu Gly Gly Trp Phe Gly Glu Leu Ala Phe Asp Tyr Trp Gly
            100                 105                 110         
Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser
        115                 120                 125             
Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala
    130                 135                 140                 
Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val
145                 150                 155                 160 
Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala
                165                 170                 175     
Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val
            180                 185                 190         
Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His
        195                 200                 205             
Lys Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu Pro Lys Ser Cys
    210                 215                 220                 
Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Phe Glu Gly
225                 230                 235                 240 
Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met
                245                 250                 255     
Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His
            260                 265                 270         
Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val
        275                 280                 285             
His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr
    290                 295                 300                 
Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly
305                 310                 315                 320 
Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Ser Ile
                325                 330                 335     
Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val
            340                 345                 350         
Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser
        355                 360                 365             
Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu
    370                 375                 380                 
Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro
385                 390                 395                 400 
Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val
                405                 410                 415     
Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met
            420                 425                 430         
His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser
        435                 440                 445             
Pro Gly Lys Gly Gly Gly Gly Ser Gly Gly Gly Ser Gln Val Gln Leu
    450                 455                 460                 
Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg Ser Leu Arg Leu
465                 470                 475                 480 
Ser Cys Ala Ala Ser Gly Arg Thr Ile Thr Thr Ile Thr Met Gly Trp
                485                 490                 495     
Phe Arg Gln Ala Pro Gly Lys Gly Leu Glu Phe Val Ala Ser His Ser
            500                 505                 510         
Trp Thr Asp Asn Asn Pro Tyr Tyr Ala Asp Ser Val Lys Gly Arg Phe
        515                 520                 525             
Ile Ile Ser Arg Asp Asn Ser Lys Asn Arg Leu Tyr Leu Gln Met Asn
    530                 535                 540                 
Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Ala Thr Ala
545                 550                 555                 560 
Arg Arg Ser Phe Val Gly Arg Gln Trp Tyr Thr Glu Ala Arg Gln Tyr
                565                 570                 575     
Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser
            580                 585                 


<210> 190
<211> 589
<212> PRT
<213> Artificial Sequence

<220> 
<223> AS02640-9GS-Durvalumab heavy chain fusion sequence

<400> 190
Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg
 1               5                  10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Thr Ile Thr Thr Ile
            20                  25                  30          
Thr Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Gly Leu Glu Phe Val
        35                  40                  45              
Ala Ser His Ser Trp Thr Asp Asn Asn Pro Tyr Tyr Ala Asp Ser Val
    50                  55                  60                  
Lys Gly Arg Phe Ile Ile Ser Arg Asp Asn Ser Lys Asn Arg Leu Tyr
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
                85                  90                  95      
Ala Ala Thr Ala Arg Arg Ser Phe Val Gly Arg Gln Trp Tyr Thr Glu
            100                 105                 110         
Ala Arg Gln Tyr Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser
        115                 120                 125             
Ser Gly Gly Gly Gly Ser Gly Gly Gly Ser Glu Val Gln Leu Val Glu
    130                 135                 140                 
Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys
145                 150                 155                 160 
Ala Ala Ser Gly Phe Thr Phe Ser Arg Tyr Trp Met Ser Trp Val Arg
                165                 170                 175     
Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ala Asn Ile Lys Gln Asp
            180                 185                 190         
Gly Ser Glu Lys Tyr Tyr Val Asp Ser Val Lys Gly Arg Phe Thr Ile
        195                 200                 205             
Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr Leu Gln Met Asn Ser Leu
    210                 215                 220                 
Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg Glu Gly Gly Trp
225                 230                 235                 240 
Phe Gly Glu Leu Ala Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr
                245                 250                 255     
Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro
            260                 265                 270         
Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val
        275                 280                 285             
Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala
    290                 295                 300                 
Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly
305                 310                 315                 320 
Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly
                325                 330                 335     
Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys
            340                 345                 350         
Val Asp Lys Arg Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys
        355                 360                 365             
Pro Pro Cys Pro Ala Pro Glu Phe Glu Gly Gly Pro Ser Val Phe Leu
    370                 375                 380                 
Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu
385                 390                 395                 400 
Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys
                405                 410                 415     
Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys
            420                 425                 430         
Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu
        435                 440                 445             
Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys
    450                 455                 460                 
Val Ser Asn Lys Ala Leu Pro Ala Ser Ile Glu Lys Thr Ile Ser Lys
465                 470                 475                 480 
Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser
                485                 490                 495     
Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys
            500                 505                 510         
Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln
        515                 520                 525             
Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly
    530                 535                 540                 
Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln
545                 550                 555                 560 
Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn
                565                 570                 575     
His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys
            580                 585                 


<210> 191
<211> 595
<212> PRT
<213> Artificial Sequence

<220> 
<223> Durvalumab-hIgG1 hinge-AS02640 heavy chain fusion sequence

<400> 191
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
 1               5                  10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Arg Tyr
            20                  25                  30          
Trp Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
        35                  40                  45              
Ala Asn Ile Lys Gln Asp Gly Ser Glu Lys Tyr Tyr Val Asp Ser Val
    50                  55                  60                  
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
                85                  90                  95      
Ala Arg Glu Gly Gly Trp Phe Gly Glu Leu Ala Phe Asp Tyr Trp Gly
            100                 105                 110         
Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser
        115                 120                 125             
Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala
    130                 135                 140                 
Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val
145                 150                 155                 160 
Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala
                165                 170                 175     
Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val
            180                 185                 190         
Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His
        195                 200                 205             
Lys Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu Pro Lys Ser Cys
    210                 215                 220                 
Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Phe Glu Gly
225                 230                 235                 240 
Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met
                245                 250                 255     
Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His
            260                 265                 270         
Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val
        275                 280                 285             
His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr
    290                 295                 300                 
Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly
305                 310                 315                 320 
Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Ser Ile
                325                 330                 335     
Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val
            340                 345                 350         
Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser
        355                 360                 365             
Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu
    370                 375                 380                 
Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro
385                 390                 395                 400 
Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val
                405                 410                 415     
Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met
            420                 425                 430         
His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser
        435                 440                 445             
Pro Gly Lys Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro
    450                 455                 460                 
Cys Pro Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro
465                 470                 475                 480 
Gly Arg Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Thr Ile Thr
                485                 490                 495     
Thr Ile Thr Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Gly Leu Glu
            500                 505                 510         
Phe Val Ala Ser His Ser Trp Thr Asp Asn Asn Pro Tyr Tyr Ala Asp
        515                 520                 525             
Ser Val Lys Gly Arg Phe Ile Ile Ser Arg Asp Asn Ser Lys Asn Arg
    530                 535                 540                 
Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr
545                 550                 555                 560 
Tyr Cys Ala Ala Thr Ala Arg Arg Ser Phe Val Gly Arg Gln Trp Tyr
                565                 570                 575     
Thr Glu Ala Arg Gln Tyr Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr
            580                 585                 590         
Val Ser Ser
        595 


<210> 192
<211> 595
<212> PRT
<213> Artificial Sequence

<220> 
<223> AS02640-hIgG1 hinge-Durvalumab heavy chain fusion sequence

<400> 192
Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg
 1               5                  10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Thr Ile Thr Thr Ile
            20                  25                  30          
Thr Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Gly Leu Glu Phe Val
        35                  40                  45              
Ala Ser His Ser Trp Thr Asp Asn Asn Pro Tyr Tyr Ala Asp Ser Val
    50                  55                  60                  
Lys Gly Arg Phe Ile Ile Ser Arg Asp Asn Ser Lys Asn Arg Leu Tyr
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
                85                  90                  95      
Ala Ala Thr Ala Arg Arg Ser Phe Val Gly Arg Gln Trp Tyr Thr Glu
            100                 105                 110         
Ala Arg Gln Tyr Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser
        115                 120                 125             
Ser Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro
    130                 135                 140                 
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
145                 150                 155                 160 
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Arg Tyr
                165                 170                 175     
Trp Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
            180                 185                 190         
Ala Asn Ile Lys Gln Asp Gly Ser Glu Lys Tyr Tyr Val Asp Ser Val
        195                 200                 205             
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr
    210                 215                 220                 
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
225                 230                 235                 240 
Ala Arg Glu Gly Gly Trp Phe Gly Glu Leu Ala Phe Asp Tyr Trp Gly
                245                 250                 255     
Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser
            260                 265                 270         
Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala
        275                 280                 285             
Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val
    290                 295                 300                 
Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala
305                 310                 315                 320 
Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val
                325                 330                 335     
Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His
            340                 345                 350         
Lys Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu Pro Lys Ser Cys
        355                 360                 365             
Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Phe Glu Gly
    370                 375                 380                 
Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met
385                 390                 395                 400 
Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His
                405                 410                 415     
Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val
            420                 425                 430         
His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr
        435                 440                 445             
Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly
    450                 455                 460                 
Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Ser Ile
465                 470                 475                 480 
Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val
                485                 490                 495     
Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser
            500                 505                 510         
Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu
        515                 520                 525             
Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro
    530                 535                 540                 
Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val
545                 550                 555                 560 
Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met
                565                 570                 575     
His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser
            580                 585                 590         
Pro Gly Lys
        595 


<210> 193
<211> 580
<212> PRT
<213> Artificial Sequence

<220> 
<223> Durvalumab-AS02640 heavy chain fusion sequence

<400> 193
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
 1               5                  10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Arg Tyr
            20                  25                  30          
Trp Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
        35                  40                  45              
Ala Asn Ile Lys Gln Asp Gly Ser Glu Lys Tyr Tyr Val Asp Ser Val
    50                  55                  60                  
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
                85                  90                  95      
Ala Arg Glu Gly Gly Trp Phe Gly Glu Leu Ala Phe Asp Tyr Trp Gly
            100                 105                 110         
Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser
        115                 120                 125             
Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala
    130                 135                 140                 
Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val
145                 150                 155                 160 
Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala
                165                 170                 175     
Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val
            180                 185                 190         
Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His
        195                 200                 205             
Lys Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu Pro Lys Ser Cys
    210                 215                 220                 
Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Phe Glu Gly
225                 230                 235                 240 
Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met
                245                 250                 255     
Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His
            260                 265                 270         
Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val
        275                 280                 285             
His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr
    290                 295                 300                 
Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly
305                 310                 315                 320 
Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Ser Ile
                325                 330                 335     
Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val
            340                 345                 350         
Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser
        355                 360                 365             
Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu
    370                 375                 380                 
Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro
385                 390                 395                 400 
Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val
                405                 410                 415     
Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met
            420                 425                 430         
His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser
        435                 440                 445             
Pro Gly Lys Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln
    450                 455                 460                 
Pro Gly Arg Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Thr Ile
465                 470                 475                 480 
Thr Thr Ile Thr Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Gly Leu
                485                 490                 495     
Glu Phe Val Ala Ser His Ser Trp Thr Asp Asn Asn Pro Tyr Tyr Ala
            500                 505                 510         
Asp Ser Val Lys Gly Arg Phe Ile Ile Ser Arg Asp Asn Ser Lys Asn
        515                 520                 525             
Arg Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val
    530                 535                 540                 
Tyr Tyr Cys Ala Ala Thr Ala Arg Arg Ser Phe Val Gly Arg Gln Trp
545                 550                 555                 560 
Tyr Thr Glu Ala Arg Gln Tyr Asp Tyr Trp Gly Gln Gly Thr Leu Val
                565                 570                 575     
Thr Val Ser Ser
            580 


<210> 194
<211> 580
<212> PRT
<213> Artificial Sequence

<220> 
<223> AS02640-Durvalumab heavy chain fusion sequence

<400> 194
Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg
 1               5                  10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Thr Ile Thr Thr Ile
            20                  25                  30          
Thr Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Gly Leu Glu Phe Val
        35                  40                  45              
Ala Ser His Ser Trp Thr Asp Asn Asn Pro Tyr Tyr Ala Asp Ser Val
    50                  55                  60                  
Lys Gly Arg Phe Ile Ile Ser Arg Asp Asn Ser Lys Asn Arg Leu Tyr
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
                85                  90                  95      
Ala Ala Thr Ala Arg Arg Ser Phe Val Gly Arg Gln Trp Tyr Thr Glu
            100                 105                 110         
Ala Arg Gln Tyr Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser
        115                 120                 125             
Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly
    130                 135                 140                 
Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Arg
145                 150                 155                 160 
Tyr Trp Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp
                165                 170                 175     
Val Ala Asn Ile Lys Gln Asp Gly Ser Glu Lys Tyr Tyr Val Asp Ser
            180                 185                 190         
Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu
        195                 200                 205             
Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr
    210                 215                 220                 
Cys Ala Arg Glu Gly Gly Trp Phe Gly Glu Leu Ala Phe Asp Tyr Trp
225                 230                 235                 240 
Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro
                245                 250                 255     
Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr
            260                 265                 270         
Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr
        275                 280                 285             
Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro
    290                 295                 300                 
Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr
305                 310                 315                 320 
Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn
                325                 330                 335     
His Lys Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu Pro Lys Ser
            340                 345                 350         
Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Phe Glu
        355                 360                 365             
Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu
    370                 375                 380                 
Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser
385                 390                 395                 400 
His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu
                405                 410                 415     
Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr
            420                 425                 430         
Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn
        435                 440                 445             
Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Ser
    450                 455                 460                 
Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln
465                 470                 475                 480 
Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val
                485                 490                 495     
Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val
            500                 505                 510         
Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro
        515                 520                 525             
Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr
    530                 535                 540                 
Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val
545                 550                 555                 560 
Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu
                565                 570                 575     
Ser Pro Gly Lys
            580 


<210> 195
<211> 448
<212> PRT
<213> Artificial Sequence

<220> 
<223> Tecentriq heavy chain

<400> 195
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
 1               5                  10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp Ser
            20                  25                  30          
Trp Ile His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
        35                  40                  45              
Ala Trp Ile Ser Pro Tyr Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val
    50                  55                  60                  
Lys Gly Arg Phe Thr Ile Ser Ala Asp Thr Ser Lys Asn Thr Ala Tyr
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
                85                  90                  95      
Ala Arg Arg His Trp Pro Gly Gly Phe Asp Tyr Trp Gly Gln Gly Thr
            100                 105                 110         
Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro
        115                 120                 125             
Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly
    130                 135                 140                 
Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn
145                 150                 155                 160 
Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln
                165                 170                 175     
Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser
            180                 185                 190         
Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser
        195                 200                 205             
Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr
    210                 215                 220                 
His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser
225                 230                 235                 240 
Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg
                245                 250                 255     
Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro
            260                 265                 270         
Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala
        275                 280                 285             
Lys Thr Lys Pro Arg Glu Glu Gln Tyr Ala Ser Thr Tyr Arg Val Val
    290                 295                 300                 
Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr
305                 310                 315                 320 
Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr
                325                 330                 335     
Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu
            340                 345                 350         
Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys
        355                 360                 365             
Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser
    370                 375                 380                 
Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp
385                 390                 395                 400 
Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser
                405                 410                 415     
Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala
            420                 425                 430         
Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys
        435                 440                 445             


<210> 196
<211> 214
<212> PRT
<213> Artificial Sequence

<220> 
<223> Light chain amino acid sequence

<400> 196
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly
 1               5                  10                  15      
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Val Ser Thr Ala
            20                  25                  30          
Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile
        35                  40                  45              
Tyr Ser Ala Ser Phe Leu Tyr Ser Gly Val Pro Ser Arg Phe Ser Gly
    50                  55                  60                  
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro
65                  70                  75                  80  
Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Leu Tyr His Pro Ala
                85                  90                  95      
Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala Ala
            100                 105                 110         
Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly
        115                 120                 125             
Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala
    130                 135                 140                 
Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln
145                 150                 155                 160 
Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser
                165                 170                 175     
Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr
            180                 185                 190         
Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser
        195                 200                 205             
Phe Asn Arg Gly Glu Cys
    210                 


<210> 197
<211> 451
<212> PRT
<213> Artificial Sequence

<220> 
<223> Durvalumab heavy chain

<400> 197
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
 1               5                  10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Arg Tyr
            20                  25                  30          
Trp Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
        35                  40                  45              
Ala Asn Ile Lys Gln Asp Gly Ser Glu Lys Tyr Tyr Val Asp Ser Val
    50                  55                  60                  
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
                85                  90                  95      
Ala Arg Glu Gly Gly Trp Phe Gly Glu Leu Ala Phe Asp Tyr Trp Gly
            100                 105                 110         
Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser
        115                 120                 125             
Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala
    130                 135                 140                 
Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val
145                 150                 155                 160 
Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala
                165                 170                 175     
Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val
            180                 185                 190         
Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His
        195                 200                 205             
Lys Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu Pro Lys Ser Cys
    210                 215                 220                 
Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Phe Glu Gly
225                 230                 235                 240 
Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met
                245                 250                 255     
Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His
            260                 265                 270         
Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val
        275                 280                 285             
His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr
    290                 295                 300                 
Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly
305                 310                 315                 320 
Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Ser Ile
                325                 330                 335     
Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val
            340                 345                 350         
Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser
        355                 360                 365             
Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu
    370                 375                 380                 
Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro
385                 390                 395                 400 
Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val
                405                 410                 415     
Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met
            420                 425                 430         
His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser
        435                 440                 445             
Pro Gly Lys
    450     


<210> 198
<211> 215
<212> PRT
<213> Artificial Sequence

<220> 
<223> Light chain amino acid sequence

<400> 198
Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly
 1               5                  10                  15      
Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Arg Val Ser Ser Ser
            20                  25                  30          
Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu
        35                  40                  45              
Ile Tyr Asp Ala Ser Ser Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser
    50                  55                  60                  
Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu
65                  70                  75                  80  
Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Gly Ser Leu Pro
                85                  90                  95      
Trp Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala
            100                 105                 110         
Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser
        115                 120                 125             
Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu
    130                 135                 140                 
Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser
145                 150                 155                 160 
Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu
                165                 170                 175     
Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val
            180                 185                 190         
Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys
        195                 200                 205             
Ser Phe Asn Arg Gly Glu Cys
    210                 215 


<210> 199
<211> 187
<212> PRT
<213> Homo sapiens

<400> 199
Ala Met His Val Ala Gln Pro Ala Val Val Leu Ala Ser Ser Arg Gly
 1               5                  10                  15      
Ile Ala Ser Phe Val Cys Glu Tyr Ala Ser Pro Gly Lys Ala Thr Glu
            20                  25                  30          
Val Arg Val Thr Val Leu Arg Gln Ala Asp Ser Gln Val Thr Glu Val
        35                  40                  45              
Cys Ala Ala Thr Tyr Met Met Gly Asn Glu Leu Thr Phe Leu Asp Asp
    50                  55                  60                  
Ser Ile Cys Thr Gly Thr Ser Ser Gly Asn Gln Val Asn Leu Thr Ile
65                  70                  75                  80  
Gln Gly Leu Arg Ala Met Asp Thr Gly Leu Tyr Ile Cys Lys Val Glu
                85                  90                  95      
Leu Met Tyr Pro Pro Pro Tyr Tyr Leu Gly Ile Gly Asn Gly Thr Gln
            100                 105                 110         
Ile Tyr Val Ile Asp Pro Glu Pro Cys Pro Asp Ser Asp Phe Leu Leu
        115                 120                 125             
Trp Ile Leu Ala Ala Val Ser Ser Gly Leu Phe Phe Tyr Ser Phe Leu
    130                 135                 140                 
Leu Thr Ala Val Ser Leu Ser Lys Met Leu Lys Lys Arg Ser Pro Leu
145                 150                 155                 160 
Thr Thr Gly Val Tyr Val Lys Met Pro Pro Thr Glu Pro Glu Cys Glu
                165                 170                 175     
Lys Gln Phe Gln Pro Tyr Phe Ile Pro Ile Asn
            180                 185         


<210> 200
<211> 129
<212> PRT
<213> Artificial Sequence

<220> 
<223> A34311-direct grafted amino acid

<400> 200
Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg
 1               5                  10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Thr Ile Thr Thr Ile
            20                  25                  30          
Thr Met Gly Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
        35                  40                  45              
Ala Ser His Ser Trp Thr Asp Asn Asn Pro Tyr Tyr Ala Asp Ser Val
    50                  55                  60                  
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
                85                  90                  95      
Ala Lys Thr Ala Arg Arg Ser Phe Val Gly Arg Gln Trp Tyr Thr Glu
            100                 105                 110         
Ala Arg Gln Tyr Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser
        115                 120                 125             
Ser
    


<210> 201
<211> 129
<212> PRT
<213> Artificial Sequence

<220> 
<223> AS02636 humanized sdAb

<400> 201
Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg
 1               5                  10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Thr Ile Thr Thr Ile
            20                  25                  30          
Thr Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Gly Arg Gln Phe Val
        35                  40                  45              
Ala Ser His Ser Trp Thr Asp Asn Asn Pro Tyr Tyr Ala Asp Ser Val
    50                  55                  60                  
Lys Gly Arg Phe Ile Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr Tyr Cys
                85                  90                  95      
Ala Ala Thr Ala Arg Arg Ser Phe Val Gly Arg Gln Trp Tyr Thr Glu
            100                 105                 110         
Ala Arg Gln Tyr Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser
        115                 120                 125             
Ser
    


<210> 202
<211> 129
<212> PRT
<213> Artificial Sequence

<220> 
<223> AS02626 humanized sdAb

<400> 202
Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg
 1               5                  10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Thr Ile Thr Thr Ile
            20                  25                  30          
Thr Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Gly Arg Glu Phe Val
        35                  40                  45              
Ala Ser His Ser Trp Thr Asp Asn Asn Pro Tyr Tyr Ala Asp Ser Val
    50                  55                  60                  
Lys Gly Arg Phe Ile Ile Ser Arg Asp Asn Ser Lys Asn Arg Leu Tyr
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
                85                  90                  95      
Ala Ala Thr Ala Arg Arg Ser Phe Val Gly Arg Gln Trp Tyr Thr Glu
            100                 105                 110         
Ala Arg Gln Tyr Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser
        115                 120                 125             
Ser
    

