                         SEQUENCE LISTING

<110>  The Governors of the University of Alberta
 
<120>  Hepatitis C Virus Immunogenic Compositions and Methods of Use 
       Thereof

<130>  V811948WO

<150>  62/406,770
<151>  2016-10-11

<160>  151   

<170>  PatentIn version 3.5

<210>  1
<211>  746
<212>  PRT
<213>  Hepatitis C virus


<220>
<221>  misc_feature
<222>  (248)..(248)
<223>  Xaa can be any amino acid

<220>
<221>  misc_feature
<222>  (262)..(262)
<223>  Xaa can be any amino acid

<220>
<221>  misc_feature
<222>  (270)..(270)
<223>  Xaa can be any amino acid

<220>
<221>  misc_feature
<222>  (275)..(275)
<223>  Xaa can be any amino acid

<220>
<221>  misc_feature
<222>  (399)..(399)
<223>  Xaa can be any amino acid

<220>
<221>  misc_feature
<222>  (408)..(408)
<223>  Xaa can be any amino acid

<220>
<221>  misc_feature
<222>  (524)..(524)
<223>  Xaa can be any amino acid

<220>
<221>  misc_feature
<222>  (580)..(580)
<223>  Xaa can be any amino acid

<220>
<221>  misc_feature
<222>  (641)..(641)
<223>  Xaa can be any amino acid

<220>
<221>  misc_feature
<222>  (709)..(709)
<223>  Xaa can be any amino acid

<220>
<221>  misc_feature
<222>  (733)..(733)
<223>  Xaa can be any amino acid

<400>  1

Met Ser Thr Asn Pro Lys Pro Gln Arg Lys Thr Lys Arg Asn Thr Asn 
1               5                   10                  15      


Arg Arg Pro Gln Asp Val Lys Phe Pro Gly Gly Gly Gln Ile Val Gly 
            20                  25                  30          


Gly Val Tyr Leu Leu Pro Arg Arg Gly Pro Arg Leu Gly Val Arg Ala 
        35                  40                  45              


Thr Arg Lys Thr Ser Glu Arg Ser Gln Pro Arg Gly Arg Arg Gln Pro 
    50                  55                  60                  


Ile Pro Lys Ala Arg Arg Pro Glu Gly Arg Thr Trp Ala Gln Pro Gly 
65                  70                  75                  80  


Tyr Pro Trp Pro Leu Tyr Gly Asn Glu Gly Cys Gly Trp Ala Gly Trp 
                85                  90                  95      


Leu Leu Ser Pro Arg Gly Ser Arg Pro Ser Trp Gly Pro Thr Asp Pro 
            100                 105                 110         


Arg Arg Arg Ser Arg Asn Leu Gly Lys Val Ile Asp Thr Leu Thr Cys 
        115                 120                 125             


Gly Phe Ala Asp Leu Met Gly Tyr Ile Pro Leu Val Gly Ala Pro Leu 
    130                 135                 140                 


Gly Gly Ala Ala Arg Ala Leu Ala His Gly Val Arg Val Leu Glu Asp 
145                 150                 155                 160 


Gly Val Asn Tyr Ala Thr Gly Asn Leu Pro Gly Cys Ser Phe Ser Ile 
                165                 170                 175     


Phe Leu Leu Ala Leu Leu Ser Cys Leu Thr Val Pro Ala Ser Ala Tyr 
            180                 185                 190         


Gln Val Arg Asn Ser Ser Gly Leu Tyr His Val Thr Asn Asp Cys Pro 
        195                 200                 205             


Asn Ser Ser Ile Val Tyr Glu Thr Ala Asp Thr Ile Leu His Ser Pro 
    210                 215                 220                 


Gly Cys Val Pro Cys Val Arg Glu Gly Asn Ala Ser Arg Cys Trp Val 
225                 230                 235                 240 


Ala Leu Thr Pro Thr Val Ala Xaa Arg Asp Gly Ser Leu Pro Thr Thr 
                245                 250                 255     


Gln Leu Arg Arg His Xaa Asp Leu Leu Val Gly Ser Ala Xaa Leu Cys 
            260                 265                 270         


Ser Ala Xaa Tyr Val Gly Asp Leu Cys Gly Ser Val Phe Leu Val Gly 
        275                 280                 285             


Gln Leu Phe Thr Phe Ser Pro Arg Arg His Trp Thr Thr Gln Asp Cys 
    290                 295                 300                 


Asn Cys Ser Ile Tyr Pro Gly His Ile Thr Gly His Arg Met Ala Trp 
305                 310                 315                 320 


Asp Met Met Met Asn Trp Ser Pro Thr Thr Ala Leu Val Val Ala Gln 
                325                 330                 335     


Leu Leu Arg Ile Pro Gln Ala Ile Leu Asp Met Ile Ala Gly Ala His 
            340                 345                 350         


Trp Gly Val Leu Ala Gly Ile Ala Tyr Phe Ser Met Val Gly Asn Trp 
        355                 360                 365             


Ala Lys Val Leu Val Val Leu Leu Leu Phe Ala Gly Val Asp Ala Glu 
    370                 375                 380                 


Thr His Val Thr Gly Gly Ser Ala Ala Arg Ala Thr Ser Gly Xaa Ala 
385                 390                 395                 400 


Ser Leu Phe Ser Pro Gly Ala Xaa Gln Asn Ile Gln Leu Ile Asn Thr 
                405                 410                 415     


Asn Gly Ser Trp His Ile Asn Arg Thr Ala Leu Asn Cys Asn Asp Ser 
            420                 425                 430         


Leu Asp Thr Gly Trp Val Ala Gly Leu Phe Tyr Tyr His Lys Phe Asn 
        435                 440                 445             


Ser Ser Gly Cys Pro Glu Arg Met Ala Ser Cys Arg Pro Leu Ala Asp 
    450                 455                 460                 


Phe Asp Gln Gly Trp Gly Pro Ile Ser Tyr Ala Asn Gly Ser Gly Pro 
465                 470                 475                 480 


Asp Gln Arg Pro Tyr Cys Trp His Tyr Pro Pro Lys Pro Cys Gly Ile 
                485                 490                 495     


Val Pro Ala Gln Gln Val Cys Gly Pro Val Tyr Cys Phe Thr Pro Ser 
            500                 505                 510         


Pro Val Val Val Gly Thr Thr Asp Arg Leu Gly Xaa Pro Thr Tyr Asn 
        515                 520                 525             


Trp Gly Glu Asn Glu Thr Asp Val Leu Val Leu Asn Asn Thr Arg Pro 
    530                 535                 540                 


Pro Leu Gly Asn Trp Phe Gly Cys Thr Trp Met Asn Ser Thr Gly Phe 
545                 550                 555                 560 


Thr Lys Val Cys Gly Ala Pro Pro Cys Asn Ile Gly Gly Val Gly Asn 
                565                 570                 575     


Asn Thr Leu Xaa Cys Pro Thr Asp Cys Phe Arg Lys His Pro Glu Ala 
            580                 585                 590         


Thr Tyr Ser Arg Cys Gly Ser Gly Pro Trp Leu Thr Pro Arg Cys Leu 
        595                 600                 605             


Val Asp Tyr Pro Tyr Arg Leu Trp His Tyr Pro Cys Thr Val Asn Tyr 
    610                 615                 620                 


Thr Ile Phe Lys Val Arg Met Tyr Val Gly Gly Val Glu His Arg Leu 
625                 630                 635                 640 


Xaa Ala Ala Cys Asn Trp Thr Arg Gly Glu Arg Cys Asp Leu Asp Asp 
                645                 650                 655     


Arg Asp Arg Ser Glu Leu Ser Pro Leu Leu Leu Ser Thr Thr Gln Trp 
            660                 665                 670         


Gln Val Leu Pro Cys Ser Phe Thr Thr Leu Pro Ala Leu Ser Thr Gly 
        675                 680                 685             


Leu Ile His Leu His Gln Asn Ile Val Asp Val Gln Tyr Leu Tyr Gly 
    690                 695                 700                 


Val Gly Ser Ser Xaa Val Ser Trp Ala Ile Lys Trp Glu Tyr Val Ile 
705                 710                 715                 720 


Leu Leu Phe Leu Leu Leu Ala Asp Ala Arg Ile Cys Xaa Cys Leu Trp 
                725                 730                 735     


Met Met Leu Leu Ile Ser Gln Ala Glu Ala 
            740                 745     


<210>  2
<211>  746
<212>  PRT
<213>  Hepatitis C virus

<400>  2

Met Ser Thr Asn Pro Lys Pro Gln Arg Lys Thr Lys Arg Asn Thr Asn 
1               5                   10                  15      


Arg Arg Pro Gln Asp Val Lys Phe Pro Gly Gly Gly Gln Ile Val Gly 
            20                  25                  30          


Gly Val Tyr Leu Leu Pro Arg Arg Gly Pro Arg Leu Gly Val Arg Ala 
        35                  40                  45              


Thr Arg Lys Thr Ser Glu Arg Ser Gln Pro Arg Gly Arg Arg Gln Pro 
    50                  55                  60                  


Ile Pro Lys Ala Arg Arg Pro Glu Gly Arg Thr Trp Ala Gln Pro Gly 
65                  70                  75                  80  


Tyr Pro Trp Pro Leu Tyr Gly Asn Glu Gly Cys Gly Trp Ala Gly Trp 
                85                  90                  95      


Leu Leu Ser Pro Arg Gly Ser Arg Pro Ser Trp Gly Pro Thr Asp Pro 
            100                 105                 110         


Arg Arg Arg Ser Arg Asn Leu Gly Lys Val Ile Asp Thr Leu Thr Cys 
        115                 120                 125             


Gly Phe Ala Asp Leu Met Gly Tyr Ile Pro Leu Val Gly Ala Pro Leu 
    130                 135                 140                 


Gly Gly Ala Ala Arg Ala Leu Ala His Gly Val Arg Val Leu Glu Asp 
145                 150                 155                 160 


Gly Val Asn Tyr Ala Thr Gly Asn Leu Pro Gly Cys Ser Phe Ser Ile 
                165                 170                 175     


Phe Leu Leu Ala Leu Leu Ser Cys Leu Thr Val Pro Ala Ser Ala Tyr 
            180                 185                 190         


Gln Val Arg Asn Ser Thr Gly Leu Tyr His Val Thr Asn Asp Cys Pro 
        195                 200                 205             


Asn Ser Ser Ile Val Tyr Glu Ala Ala Asp Ala Ile Leu His Thr Pro 
    210                 215                 220                 


Gly Cys Val Pro Cys Val Arg Glu Gly Asn Thr Ser Arg Cys Trp Val 
225                 230                 235                 240 


Ala Met Thr Pro Thr Val Ala Thr Arg Asp Gly Lys Leu Pro Thr Thr 
                245                 250                 255     


Gln Leu Arg Arg His Ile Asp Leu Leu Val Gly Ser Ala Thr Leu Cys 
            260                 265                 270         


Ser Ala Leu Tyr Val Gly Asp Leu Cys Gly Ser Ile Phe Leu Val Gly 
        275                 280                 285             


Gln Met Phe Thr Phe Ser Pro Arg Arg His Trp Thr Thr Gln Asp Cys 
    290                 295                 300                 


Asn Cys Ser Leu Tyr Pro Gly His Ile Thr Gly His Arg Met Ala Trp 
305                 310                 315                 320 


Asp Met Met Met Asn Trp Ser Pro Thr Ala Ala Leu Ile Thr Ala Gln 
                325                 330                 335     


Leu Leu Arg Ile Pro Gln Ala Ile Leu Asp Met Ile Ala Gly Ala His 
            340                 345                 350         


Trp Gly Val Leu Ala Gly Ile Ala Tyr Phe Ser Met Val Gly Asn Trp 
        355                 360                 365             


Ala Lys Val Leu Val Val Leu Leu Leu Phe Ala Gly Val Asp Ala Gln 
    370                 375                 380                 


Thr His Val Thr Gly Gly Arg Ala Ala His Ile Thr Ala Gly Leu Thr 
385                 390                 395                 400 


Ser Leu Phe Ser Pro Gly Pro Ser Gln Lys Leu Gln Leu Val Asn Thr 
                405                 410                 415     


Asn Gly Ser Trp His Ile Asn Ser Thr Ala Leu Asn Cys Asn Asp Ser 
            420                 425                 430         


Leu Lys Thr Gly Trp Ile Ala Gly Leu Leu Tyr Ser Tyr Lys Phe Asn 
        435                 440                 445             


Ser Ser Gly Cys Pro Glu Arg Leu Ala Ser Cys Arg Arg Leu Thr Asp 
    450                 455                 460                 


Phe Ala Gln Gly Trp Gly Pro Ile Ser His Ala Asn Gly Ser Gly Pro 
465                 470                 475                 480 


Asp Glu Arg Pro Tyr Cys Trp His Tyr Pro Pro Arg Pro Cys Gly Ile 
                485                 490                 495     


Val Pro Ala Lys Ser Val Cys Gly Pro Val Tyr Cys Phe Thr Pro Ser 
            500                 505                 510         


Pro Val Val Val Gly Thr Thr Asp Lys Ser Gly Ala Pro Thr Tyr Asn 
        515                 520                 525             


Trp Gly Glu Asn Asp Thr Asp Val Phe Val Leu Asn Asn Thr Arg Pro 
    530                 535                 540                 


Pro Leu Gly Asn Trp Phe Gly Cys Thr Trp Met Asn Ser Thr Gly Phe 
545                 550                 555                 560 


Thr Lys Val Cys Gly Ala Pro Pro Cys Val Ile Gly Gly Ala Gly Asn 
                565                 570                 575     


Asn Thr Leu Arg Cys Pro Thr Asp Cys Phe Arg Lys His Pro Asp Ala 
            580                 585                 590         


Thr Tyr Ser Arg Cys Gly Ser Gly Pro Trp Ile Thr Pro Arg Cys Leu 
        595                 600                 605             


Val Asp Tyr Pro Tyr Arg Leu Trp His Tyr Pro Cys Thr Val Asn Tyr 
    610                 615                 620                 


Ser Ile Phe Lys Ile Arg Met Tyr Leu Gly Gly Val Glu His Arg Leu 
625                 630                 635                 640 


Glu Ala Ala Cys Asn Trp Thr Arg Gly Glu Arg Cys Asp Leu Glu Asp 
                645                 650                 655     


Arg Asp Arg Ser Glu Leu Ser Pro Leu Leu Leu Ser Thr Thr Gln Trp 
            660                 665                 670         


Gln Val Leu Pro Cys Ser Phe Thr Thr Leu Pro Ala Leu Ser Thr Gly 
        675                 680                 685             


Leu Ile His Leu His Gln Asn Ile Val Asp Val Gln Tyr Leu Tyr Gly 
    690                 695                 700                 


Val Gly Ser Ser Val Ala Ser Trp Ala Ile Lys Trp Asp Tyr Val Val 
705                 710                 715                 720 


Leu Leu Phe Leu Leu Leu Ala Asp Ala Arg Ile Cys Ser Cys Leu Trp 
                725                 730                 735     


Met Met Leu Leu Ile Ser Gln Ala Glu Ala 
            740                 745     


<210>  3
<211>  746
<212>  PRT
<213>  Hepatitis C virus

<400>  3

Met Ser Thr Asn Pro Lys Pro Gln Arg Lys Thr Lys Arg Asn Thr Asn 
1               5                   10                  15      


Arg Arg Pro Gln Asp Val Lys Phe Pro Gly Gly Gly Gln Ile Val Gly 
            20                  25                  30          


Gly Val Tyr Leu Leu Pro Arg Arg Gly Pro Arg Leu Gly Val Arg Ala 
        35                  40                  45              


Thr Arg Lys Thr Ser Glu Arg Ser Gln Pro Arg Gly Arg Arg Gln Pro 
    50                  55                  60                  


Ile Pro Lys Ala Arg Arg Pro Glu Gly Arg Thr Trp Ala Gln Pro Gly 
65                  70                  75                  80  


Tyr Pro Trp Pro Leu Tyr Gly Asn Glu Gly Cys Gly Trp Ala Gly Trp 
                85                  90                  95      


Leu Leu Ser Pro Arg Gly Ser Arg Pro Ser Trp Gly Pro Thr Asp Pro 
            100                 105                 110         


Arg Arg Arg Ser Arg Asn Leu Gly Lys Val Ile Asp Thr Leu Thr Cys 
        115                 120                 125             


Gly Phe Ala Asp Leu Met Gly Tyr Ile Pro Leu Val Gly Ala Pro Leu 
    130                 135                 140                 


Gly Gly Ala Ala Arg Ala Leu Ala His Gly Val Arg Val Leu Glu Asp 
145                 150                 155                 160 


Gly Val Asn Tyr Ala Thr Gly Asn Leu Pro Gly Cys Ser Phe Ser Ile 
                165                 170                 175     


Phe Leu Leu Ala Leu Leu Ser Cys Leu Thr Val Pro Ala Ser Ala Tyr 
            180                 185                 190         


Gln Val Arg Asn Ser Ser Gly Leu Tyr His Val Thr Asn Asp Cys Pro 
        195                 200                 205             


Asn Ser Ser Ile Val Tyr Glu Ala Ala Asp Ala Ile Leu His Thr Pro 
    210                 215                 220                 


Gly Cys Val Pro Cys Val Arg Glu Gly Asn Ala Ser Arg Cys Trp Val 
225                 230                 235                 240 


Ala Val Thr Pro Thr Val Ala Thr Arg Asp Gly Lys Leu Pro Thr Thr 
                245                 250                 255     


Gln Leu Arg Arg His Ile Asp Leu Leu Val Gly Ser Ala Thr Leu Cys 
            260                 265                 270         


Ser Ala Leu Tyr Val Gly Asp Leu Cys Gly Ser Val Phe Leu Val Gly 
        275                 280                 285             


Gln Leu Phe Thr Phe Ser Pro Arg Arg His Trp Thr Thr Gln Asp Cys 
    290                 295                 300                 


Asn Cys Ser Ile Tyr Pro Gly His Ile Thr Gly His Arg Met Ala Trp 
305                 310                 315                 320 


Asp Met Met Met Asn Trp Ser Pro Thr Ala Ala Leu Val Val Ala Gln 
                325                 330                 335     


Leu Leu Arg Ile Pro Gln Ala Ile Met Asp Met Ile Ala Gly Ala His 
            340                 345                 350         


Trp Gly Val Leu Ala Gly Ile Ala Tyr Phe Ser Met Val Gly Asn Trp 
        355                 360                 365             


Ala Lys Val Leu Val Val Leu Leu Leu Phe Ala Gly Val Asp Ala Glu 
    370                 375                 380                 


Thr His Val Thr Gly Gly Ser Ala Gly Arg Thr Thr Ala Gly Leu Val 
385                 390                 395                 400 


Gly Leu Leu Thr Pro Gly Ala Lys Gln Asn Ile Gln Leu Ile Asn Thr 
                405                 410                 415     


Asn Gly Ser Trp His Ile Asn Ser Thr Ala Leu Asn Cys Asn Glu Ser 
            420                 425                 430         


Leu Asn Thr Gly Trp Leu Ala Gly Leu Phe Tyr Gln His Lys Phe Asn 
        435                 440                 445             


Ser Ser Gly Cys Pro Glu Arg Leu Ala Ser Cys Arg Arg Leu Thr Asp 
    450                 455                 460                 


Phe Ala Gln Gly Trp Gly Pro Ile Ser Tyr Ala Asn Gly Ser Gly Leu 
465                 470                 475                 480 


Asp Glu Arg Pro Tyr Cys Trp His Tyr Pro Pro Arg Pro Cys Gly Ile 
                485                 490                 495     


Val Pro Ala Lys Ser Val Cys Gly Pro Val Tyr Cys Phe Thr Pro Ser 
            500                 505                 510         


Pro Val Val Val Gly Thr Thr Asp Arg Ser Gly Ala Pro Thr Tyr Ser 
        515                 520                 525             


Trp Gly Ala Asn Asp Thr Asp Val Phe Val Leu Asn Asn Thr Arg Pro 
    530                 535                 540                 


Pro Leu Gly Asn Trp Phe Gly Cys Thr Trp Met Asn Ser Thr Gly Phe 
545                 550                 555                 560 


Thr Lys Val Cys Gly Ala Pro Pro Cys Val Ile Gly Gly Val Gly Asn 
                565                 570                 575     


Asn Thr Leu Leu Cys Pro Thr Asp Cys Phe Arg Lys His Pro Glu Ala 
            580                 585                 590         


Thr Tyr Ser Arg Cys Gly Ser Gly Pro Trp Ile Thr Pro Arg Cys Met 
        595                 600                 605             


Val Asp Tyr Pro Tyr Arg Leu Trp His Tyr Pro Cys Thr Ile Asn Tyr 
    610                 615                 620                 


Thr Ile Phe Lys Val Arg Met Tyr Val Gly Gly Val Glu His Arg Leu 
625                 630                 635                 640 


Glu Ala Ala Cys Asn Trp Thr Arg Gly Glu Arg Cys Asp Leu Glu Asp 
                645                 650                 655     


Arg Asp Arg Ser Glu Leu Ser Pro Leu Leu Leu Ser Thr Thr Gln Trp 
            660                 665                 670         


Gln Val Leu Pro Cys Ser Phe Thr Thr Leu Pro Ala Leu Ser Thr Gly 
        675                 680                 685             


Leu Ile His Leu His Gln Asn Ile Val Asp Val Gln Tyr Leu Tyr Gly 
    690                 695                 700                 


Val Gly Ser Ser Ile Ala Ser Trp Ala Ile Lys Trp Glu Tyr Val Val 
705                 710                 715                 720 


Leu Leu Phe Leu Leu Leu Ala Asp Ala Arg Val Cys Ser Cys Leu Trp 
                725                 730                 735     


Met Met Leu Leu Ile Ser Gln Ala Glu Ala 
            740                 745     


<210>  4
<211>  746
<212>  PRT
<213>  Hepatitis C virus

<400>  4

Met Ser Thr Asn Pro Lys Pro Gln Arg Lys Thr Lys Arg Asn Thr Asn 
1               5                   10                  15      


Arg Arg Pro Gln Asp Val Lys Phe Pro Gly Gly Gly Gln Ile Val Gly 
            20                  25                  30          


Gly Val Tyr Leu Leu Pro Arg Arg Gly Pro Arg Leu Gly Val Arg Ala 
        35                  40                  45              


Val Arg Lys Thr Ser Glu Arg Ser Gln Pro Arg Gly Arg Arg Gln Pro 
    50                  55                  60                  


Ile Pro Lys Ala Arg Arg Pro Glu Gly Arg Thr Trp Ala Gln Pro Gly 
65                  70                  75                  80  


Tyr Pro Trp Pro Leu Tyr Gly Asn Glu Gly Cys Gly Trp Ala Gly Trp 
                85                  90                  95      


Leu Leu Ser Pro Arg Gly Ser Arg Pro Ser Trp Gly Pro Thr Asp Pro 
            100                 105                 110         


Arg Arg Arg Ser Arg Asn Leu Gly Lys Val Ile Asp Thr Leu Thr Cys 
        115                 120                 125             


Gly Phe Ala Asp Leu Met Gly Tyr Ile Pro Leu Val Gly Ala Pro Leu 
    130                 135                 140                 


Gly Gly Ala Ala Arg Ala Leu Ala His Gly Val Arg Val Leu Glu Asp 
145                 150                 155                 160 


Gly Val Asn Tyr Ala Thr Gly Asn Leu Pro Gly Cys Ser Phe Ser Ile 
                165                 170                 175     


Phe Leu Leu Ala Leu Leu Ser Cys Leu Thr Val Pro Ala Ser Ala Tyr 
            180                 185                 190         


Gln Val Arg Asn Ser Ser Gly Ile Tyr His Val Thr Asn Asp Cys Pro 
        195                 200                 205             


Asn Ser Ser Ile Val Tyr Glu Thr Ala Asp Thr Ile Leu His Ser Pro 
    210                 215                 220                 


Gly Cys Val Pro Cys Val Arg Glu Gly Asn Ala Ser Lys Cys Trp Val 
225                 230                 235                 240 


Ala Leu Ala Pro Thr Val Ala Thr Arg Asp Gly Lys Leu Pro Thr Thr 
                245                 250                 255     


Gln Leu Arg Arg His Ile Asp Leu Leu Val Gly Ser Ala Thr Leu Cys 
            260                 265                 270         


Ser Ala Leu Tyr Val Gly Asp Leu Cys Gly Ser Val Phe Leu Val Gly 
        275                 280                 285             


Gln Leu Phe Thr Phe Ser Pro Arg Arg His Trp Thr Thr Gln Asp Cys 
    290                 295                 300                 


Asn Cys Ser Ile Tyr Pro Gly His Ile Thr Gly His Arg Met Ala Trp 
305                 310                 315                 320 


Asp Met Met Met Asn Trp Ser Pro Thr Thr Ala Leu Val Val Ala Gln 
                325                 330                 335     


Leu Leu Arg Val Pro Gln Ala Ile Leu Asp Met Ile Ala Gly Ala His 
            340                 345                 350         


Trp Gly Val Leu Ala Gly Ile Ala Tyr Phe Ser Met Val Gly Asn Trp 
        355                 360                 365             


Ala Lys Val Leu Val Val Leu Leu Leu Phe Ala Gly Val Asp Ala Glu 
    370                 375                 380                 


Thr Tyr Thr Thr Gly Gly Ser Val Ala Gln Ala Ala Phe Gly Leu Thr 
385                 390                 395                 400 


Ser Leu Phe Arg Pro Gly Pro Lys Gln Asp Ile Gln Leu Ile Asn Thr 
                405                 410                 415     


Asn Gly Ser Trp His Ile Asn Arg Thr Ala Leu Asn Cys Asn Ala Ser 
            420                 425                 430         


Leu Asp Thr Gly Trp Val Ala Gly Leu Phe Tyr Tyr His Lys Phe Asn 
        435                 440                 445             


Ser Ser Gly Cys Pro Glu Arg Met Ala Ser Cys Arg Ser Leu Ala Asp 
    450                 455                 460                 


Phe Asp Gln Gly Trp Gly Pro Ile Ser Tyr Ala Asn Gly Ser Gly Pro 
465                 470                 475                 480 


Glu His Arg Pro Tyr Cys Trp His Tyr Pro Pro Lys Pro Cys Gly Ile 
                485                 490                 495     


Val Pro Ala Gln Asn Val Cys Gly Pro Val Tyr Cys Phe Thr Pro Ser 
            500                 505                 510         


Pro Val Val Val Gly Thr Thr Asn Lys Leu Gly Val Pro Thr Tyr Ser 
        515                 520                 525             


Trp Gly Ser Asn Glu Thr Asp Val Leu Val Leu Asn Asn Thr Arg Pro 
    530                 535                 540                 


Pro Leu Gly Asn Trp Phe Gly Cys Thr Trp Met Asn Ser Ser Gly Phe 
545                 550                 555                 560 


Thr Lys Val Cys Gly Ala Pro Pro Cys Val Ile Gly Gly Ala Gly Asn 
                565                 570                 575     


Arg Thr Leu His Cys Pro Thr Asp Cys Phe Arg Lys His Pro Glu Ala 
            580                 585                 590         


Thr Tyr Ser Arg Cys Gly Ser Gly Pro Trp Ile Thr Pro Arg Cys Leu 
        595                 600                 605             


Val His Tyr Pro Tyr Arg Leu Trp His Tyr Pro Cys Thr Val Asn Tyr 
    610                 615                 620                 


Thr Met Phe Lys Val Arg Met Tyr Val Gly Gly Val Glu His Arg Leu 
625                 630                 635                 640 


Glu Val Ala Cys Asn Trp Thr Arg Gly Glu Arg Cys Asp Leu Asp Asp 
                645                 650                 655     


Arg Asp Arg Ser Glu Leu Ser Pro Leu Leu Leu Ser Thr Thr Gln Trp 
            660                 665                 670         


Gln Val Leu Pro Cys Ser Phe Thr Thr Leu Pro Ala Leu Thr Thr Gly 
        675                 680                 685             


Leu Ile His Leu His Gln Asn Ile Val Asp Val Gln Tyr Leu Tyr Gly 
    690                 695                 700                 


Val Gly Ser Ser Ile Val Ser Trp Ala Ile Lys Trp Glu Tyr Val Ile 
705                 710                 715                 720 


Leu Leu Phe Leu Leu Leu Ala Asp Ala Arg Ile Cys Ser Cys Leu Trp 
                725                 730                 735     


Met Met Leu Leu Ile Ser Gln Ala Glu Ala 
            740                 745     


<210>  5
<211>  746
<212>  PRT
<213>  Hepatitis C virus

<400>  5

Met Ser Thr Asn Pro Lys Pro Gln Arg Lys Thr Lys Arg Asn Thr Asn 
1               5                   10                  15      


Arg Arg Pro Gln Asp Val Lys Phe Pro Gly Gly Gly Gln Ile Val Gly 
            20                  25                  30          


Gly Val Tyr Leu Leu Pro Arg Arg Gly Pro Arg Leu Gly Val Arg Ala 
        35                  40                  45              


Thr Arg Lys Thr Ser Glu Arg Ser Gln Pro Arg Gly Arg Arg Gln Pro 
    50                  55                  60                  


Ile Pro Lys Ala Arg Arg Pro Glu Gly Arg Ser Trp Ala Gln Pro Gly 
65                  70                  75                  80  


Tyr Pro Trp Pro Leu Tyr Gly Asn Glu Gly Cys Gly Trp Ala Gly Trp 
                85                  90                  95      


Leu Leu Ser Pro Arg Gly Ser Arg Pro Ser Trp Gly Pro Thr Asp Pro 
            100                 105                 110         


Arg Arg Arg Ser Arg Asn Leu Gly Lys Val Ile Asp Thr Leu Thr Cys 
        115                 120                 125             


Gly Phe Ala Asp Leu Met Gly Tyr Ile Pro Leu Val Gly Ala Pro Leu 
    130                 135                 140                 


Gly Gly Ala Ala Arg Ala Leu Ala His Gly Val Arg Val Leu Glu Asp 
145                 150                 155                 160 


Gly Val Asn Tyr Ala Thr Gly Asn Leu Pro Gly Cys Ser Phe Ser Ile 
                165                 170                 175     


Phe Leu Leu Ala Leu Leu Ser Cys Leu Thr Val Pro Ala Ser Ala Phe 
            180                 185                 190         


Gln Val Arg Asn Ser Ser Gly Leu Tyr His Val Thr Asn Asp Cys Pro 
        195                 200                 205             


Asn Ser Ser Ile Val Tyr Glu Thr Ala Asp Thr Ile Leu His Ser Pro 
    210                 215                 220                 


Gly Cys Val Pro Cys Val Arg Glu Asp Asn Thr Ser Arg Cys Trp Val 
225                 230                 235                 240 


Ala Val Ala Pro Thr Val Ala Thr Arg Asp Gly Arg Leu Pro Thr Thr 
                245                 250                 255     


Gln Leu Arg Arg His Ile Asp Leu Leu Val Gly Ser Ala Thr Leu Cys 
            260                 265                 270         


Ser Ala Leu Tyr Val Gly Asp Leu Cys Gly Ser Val Phe Leu Val Gly 
        275                 280                 285             


Gln Leu Phe Thr Phe Ser Pro Arg Arg His Trp Thr Thr Gln Asp Cys 
    290                 295                 300                 


Asn Cys Ser Ile Tyr Pro Gly His Ile Thr Gly His Arg Met Ala Trp 
305                 310                 315                 320 


Asp Met Met Met Asn Trp Ser Pro Thr Thr Ala Leu Val Val Ala Gln 
                325                 330                 335     


Leu Leu Arg Val Pro Gln Ala Ile Leu Asp Met Ile Ala Gly Ala His 
            340                 345                 350         


Trp Gly Val Leu Ala Gly Ile Ala Tyr Phe Ser Met Val Gly Asn Trp 
        355                 360                 365             


Ala Lys Val Leu Val Val Leu Leu Leu Phe Ala Ser Val Asp Ala Glu 
    370                 375                 380                 


Thr Tyr Thr Ser Gly Gly Ser Val Ala Arg Ala Thr Ala Gly Phe Ala 
385                 390                 395                 400 


Gly Ile Phe Asn Pro Gly Ala Lys Gln Asp Ile Gln Leu Ile Asn Thr 
                405                 410                 415     


Asn Gly Ser Trp His Ile Asn Arg Thr Ala Leu Asn Cys Asn Ala Ser 
            420                 425                 430         


Leu Asp Thr Gly Trp Val Ala Gly Leu Phe Tyr Tyr His Lys Phe Asn 
        435                 440                 445             


Ser Ser Gly Cys Pro Glu Arg Met Ala Ser Cys Lys Pro Leu Ala His 
    450                 455                 460                 


Phe Ala Gln Gly Trp Gly Pro Ile Ser Tyr Ala Asn Gly Ser Gly Pro 
465                 470                 475                 480 


Asp His Arg Pro Tyr Cys Trp His Tyr Pro Pro Lys Pro Cys Gly Ile 
                485                 490                 495     


Val Pro Ala Gln Asn Val Cys Gly Pro Val Tyr Cys Phe Thr Pro Ser 
            500                 505                 510         


Pro Val Val Val Gly Thr Thr Asn Lys Leu Gly Ala Pro Thr Tyr Asn 
        515                 520                 525             


Trp Gly Ser Asn Asp Thr Asp Val Phe Ile Leu Asn Asn Thr Arg Pro 
    530                 535                 540                 


Pro Gly Gly Asn Trp Phe Gly Cys Thr Trp Met Asn Ser Ser Gly Phe 
545                 550                 555                 560 


Thr Lys Val Cys Gly Ala Pro Pro Cys Thr Ile Gly Gly Val Gly Asn 
                565                 570                 575     


Asn Thr Leu Leu Cys Pro Thr Asp Cys Phe Arg Lys His Pro Glu Ala 
            580                 585                 590         


Thr Tyr Ser Arg Cys Gly Ser Gly Pro Trp Val Thr Pro Arg Phe Leu 
        595                 600                 605             


Val His Tyr Pro Tyr Arg Leu Trp His Tyr Pro Cys Thr Val Asn Tyr 
    610                 615                 620                 


Thr Leu Phe Lys Val Arg Met Tyr Val Gly Gly Val Glu His Arg Leu 
625                 630                 635                 640 


Glu Val Ala Cys Asn Trp Thr Arg Gly Glu Arg Cys Asp Leu Asp Asp 
                645                 650                 655     


Arg Asp Arg Ser Glu Leu Ser Pro Leu Leu Leu Ser Thr Thr Gln Trp 
            660                 665                 670         


Gln Val Leu Pro Cys Ser Phe Thr Thr Leu Pro Ala Leu Thr Thr Gly 
        675                 680                 685             


Leu Ile His Leu His Gln Asn Ile Val Asp Val Gln Tyr Leu Tyr Gly 
    690                 695                 700                 


Val Gly Ser Ser Leu Val Ser Trp Ala Ile Lys Trp Glu Tyr Val Ile 
705                 710                 715                 720 


Leu Leu Phe Leu Leu Leu Ala Asp Ala Arg Ile Cys Ser Cys Leu Trp 
                725                 730                 735     


Met Met Leu Leu Ile Ser Gln Ala Glu Ala 
            740                 745     


<210>  6
<211>  746
<212>  PRT
<213>  Hepatitis C virus

<400>  6

Met Ser Thr Asn Pro Lys Pro Gln Arg Lys Thr Lys Arg Asn Thr Asn 
1               5                   10                  15      


Arg Arg Pro Gln Asp Val Lys Phe Pro Gly Gly Gly Gln Ile Val Gly 
            20                  25                  30          


Gly Val Tyr Leu Leu Pro Arg Arg Gly Pro Arg Leu Gly Val Arg Ala 
        35                  40                  45              


Thr Arg Lys Thr Ser Glu Arg Ser Gln Pro Arg Gly Arg Arg Gln Pro 
    50                  55                  60                  


Ile Pro Lys Ala Arg Arg Pro Glu Gly Arg Thr Trp Ala Gln Pro Gly 
65                  70                  75                  80  


Tyr Pro Trp Pro Leu Tyr Gly Asn Glu Gly Cys Gly Trp Ala Gly Trp 
                85                  90                  95      


Leu Leu Ser Pro Arg Gly Ser Arg Pro Ser Trp Gly Pro Thr Asp Pro 
            100                 105                 110         


Arg Arg Arg Ser Arg Asn Leu Gly Lys Val Ile Asp Thr Leu Thr Cys 
        115                 120                 125             


Gly Phe Ala Asp Leu Met Gly Tyr Ile Pro Leu Val Gly Ala Pro Leu 
    130                 135                 140                 


Gly Gly Ala Ala Arg Ala Leu Ala His Gly Val Arg Val Leu Glu Asp 
145                 150                 155                 160 


Gly Val Asn Tyr Ala Thr Gly Asn Leu Pro Gly Cys Ser Phe Ser Ile 
                165                 170                 175     


Phe Leu Leu Ala Leu Leu Ser Cys Leu Thr Val Pro Ala Ser Ala Tyr 
            180                 185                 190         


Gln Val Arg Asn Ser Ser Gly Leu Tyr His Val Thr Asn Asp Cys Pro 
        195                 200                 205             


Asn Ser Ser Ile Val Tyr Glu Thr Ala Asp Thr Ile Leu His Ser Pro 
    210                 215                 220                 


Gly Cys Val Pro Cys Val Arg Glu Gly Asn Thr Ser Lys Cys Trp Val 
225                 230                 235                 240 


Ala Val Ala Pro Thr Val Ala Thr Arg Asp Gly Lys Leu Pro Thr Thr 
                245                 250                 255     


Gln Leu Arg Arg His Ile Asp Leu Leu Val Gly Ser Ala Thr Leu Cys 
            260                 265                 270         


Ser Ala Leu Tyr Val Gly Asp Leu Cys Gly Ser Val Phe Leu Val Gly 
        275                 280                 285             


Gln Leu Phe Thr Phe Ser Pro Arg Arg His Trp Thr Thr Gln Asp Cys 
    290                 295                 300                 


Asn Cys Ser Ile Tyr Pro Gly His Ile Thr Gly His Arg Met Ala Trp 
305                 310                 315                 320 


Asp Met Met Met Asn Trp Ser Pro Thr Ala Ala Leu Val Thr Ala Gln 
                325                 330                 335     


Leu Leu Arg Val Pro Gln Ala Ile Leu Asp Met Ile Ala Gly Ala His 
            340                 345                 350         


Trp Gly Val Leu Ala Gly Ile Ala Tyr Phe Ser Met Ala Gly Asn Trp 
        355                 360                 365             


Ala Lys Val Leu Leu Val Leu Leu Leu Phe Ala Gly Val Asp Ala Glu 
    370                 375                 380                 


Thr Tyr Thr Thr Gly Gly Ser Val Ala Arg Thr Thr Arg Gly Leu Ala 
385                 390                 395                 400 


Ser Leu Leu Gln Val Gly Pro Lys Gln Asp Ile Arg Leu Ile His Thr 
                405                 410                 415     


Asn Gly Ser Trp His Ile Asn Arg Thr Ala Leu Asn Cys Asn Ala Ser 
            420                 425                 430         


Leu Asp Thr Gly Trp Leu Ala Gly Leu Leu Tyr Tyr His Lys Phe Asn 
        435                 440                 445             


Ser Ser Gly Cys Pro Glu Arg Met Ala Ser Cys Arg Pro Leu Ala Asp 
    450                 455                 460                 


Phe Asp Gln Gly Trp Gly Pro Ile Ser Tyr Ala Asn Gly Ser Gly Pro 
465                 470                 475                 480 


Glu His Arg Pro Tyr Cys Trp His Tyr Pro Pro Lys Pro Cys Gly Ile 
                485                 490                 495     


Val Pro Ala Gln Thr Val Cys Gly Pro Val Tyr Cys Phe Thr Pro Ser 
            500                 505                 510         


Pro Val Val Val Gly Thr Thr Asn Lys Leu Gly Val Pro Thr Tyr Thr 
        515                 520                 525             


Trp Gly Ser Asn Asp Thr Asp Val Phe Val Leu Asn Asn Thr Arg Pro 
    530                 535                 540                 


Pro Leu Gly Asn Trp Phe Gly Cys Thr Trp Met Asn Ser Thr Gly Phe 
545                 550                 555                 560 


Thr Lys Val Cys Gly Ala Pro Pro Cys Val Ile Gly Gly Val Gly Asn 
                565                 570                 575     


Asn Thr Leu His Cys Pro Thr Asp Cys Phe Arg Lys His Pro Glu Ala 
            580                 585                 590         


Thr Tyr Ser Arg Cys Gly Ser Gly Pro Trp Ile Thr Pro Arg Cys Leu 
        595                 600                 605             


Val Asp Tyr Pro Tyr Arg Leu Trp His Tyr Pro Cys Thr Val Asn Tyr 
    610                 615                 620                 


Thr Leu Phe Lys Val Arg Met Tyr Val Gly Gly Val Glu His Arg Leu 
625                 630                 635                 640 


Gln Ala Ala Cys Asn Trp Thr Arg Gly Glu Arg Cys Asp Leu Asp Asp 
                645                 650                 655     


Arg Asp Arg Ser Glu Leu Ser Pro Leu Leu Leu Ser Thr Thr Gln Trp 
            660                 665                 670         


Gln Val Leu Pro Cys Ser Phe Thr Thr Leu Pro Ala Leu Thr Thr Gly 
        675                 680                 685             


Leu Ile His Leu His Gln Asn Ile Val Asp Val Gln Tyr Leu Tyr Gly 
    690                 695                 700                 


Val Gly Ser Ser Ile Val Ser Trp Ala Ile Lys Trp Glu Tyr Val Ile 
705                 710                 715                 720 


Leu Leu Phe Leu Leu Leu Ala Asp Ala Arg Ile Cys Ser Cys Leu Trp 
                725                 730                 735     


Met Met Leu Leu Ile Ser Gln Ala Glu Ala 
            740                 745     


<210>  7
<211>  746
<212>  PRT
<213>  Hepatitis C virus

<400>  7

Met Ser Thr Asn Pro Lys Pro Gln Arg Lys Thr Lys Arg Asn Thr Asn 
1               5                   10                  15      


Arg Arg Pro Gln Asp Val Lys Phe Pro Gly Gly Gly Gln Ile Val Gly 
            20                  25                  30          


Gly Val Tyr Leu Leu Pro Arg Arg Gly Pro Arg Leu Gly Val Arg Ala 
        35                  40                  45              


Thr Arg Lys Thr Ser Glu Arg Ser Gln Pro Arg Gly Arg Arg Gln Pro 
    50                  55                  60                  


Ile Pro Lys Ala Arg Arg Pro Glu Gly Arg Thr Trp Ala Gln Pro Gly 
65                  70                  75                  80  


Tyr Pro Trp Pro Leu Tyr Gly Asn Glu Gly Cys Gly Trp Ala Gly Trp 
                85                  90                  95      


Leu Leu Ser Pro Arg Gly Ser Arg Pro Ser Trp Gly Pro Thr Asp Pro 
            100                 105                 110         


Arg Arg Arg Ser Arg Asn Leu Gly Lys Val Ile Asp Thr Leu Thr Cys 
        115                 120                 125             


Gly Phe Ala Asp Leu Met Gly Tyr Ile Pro Leu Val Gly Ala Pro Leu 
    130                 135                 140                 


Gly Gly Ala Ala Arg Ala Leu Ala His Gly Val Arg Val Leu Glu Asp 
145                 150                 155                 160 


Gly Val Asn Tyr Ala Thr Gly Asn Leu Pro Gly Cys Ser Phe Ser Ile 
                165                 170                 175     


Phe Leu Leu Ala Leu Leu Ser Cys Leu Thr Val Pro Ala Ser Ala Tyr 
            180                 185                 190         


Gln Val Arg Asn Ser Ser Gly Leu Tyr His Val Thr Asn Asp Cys Pro 
        195                 200                 205             


Asn Ser Ser Ile Val Tyr Glu Thr Ala Asp Thr Ile Leu His Ser Pro 
    210                 215                 220                 


Gly Cys Val Pro Cys Val Arg Glu Asp Asn Ala Ser Arg Cys Trp Val 
225                 230                 235                 240 


Pro Val Ala Pro Thr Val Ala Thr Arg Asp Gly Lys Leu Pro Thr Thr 
                245                 250                 255     


Gln Leu Arg Arg His Ile Asp Leu Leu Val Gly Ser Ala Thr Leu Cys 
            260                 265                 270         


Ser Ala Leu Tyr Val Gly Asp Leu Cys Gly Ser Val Phe Leu Val Ser 
        275                 280                 285             


Gln Leu Phe Thr Phe Ser Pro Arg Arg His Trp Thr Thr Gln Asp Cys 
    290                 295                 300                 


Asn Cys Ser Ile Tyr Pro Gly His Ile Thr Gly His Arg Met Ala Trp 
305                 310                 315                 320 


Asp Met Met Met Asn Trp Ser Pro Thr Val Ala Leu Val Met Ala Gln 
                325                 330                 335     


Leu Leu Arg Val Pro Gln Ala Ile Leu Asp Met Ile Ala Gly Ala His 
            340                 345                 350         


Trp Gly Val Leu Ala Gly Ile Ala Tyr Phe Ser Met Val Gly Asn Trp 
        355                 360                 365             


Ala Lys Val Leu Val Val Leu Leu Leu Phe Ala Gly Val Asp Ala Gln 
    370                 375                 380                 


Thr Tyr Val Thr Gly Gly Ser Ala Ala Arg Gly Ala Ser Gly Leu Ala 
385                 390                 395                 400 


Asn Leu Phe Thr Pro Gly Ala Lys Gln Asp Ile Gln Leu Ile Asn Thr 
                405                 410                 415     


Asn Gly Ser Trp His Ile Asn Arg Thr Ala Leu Asn Cys Asn Ala Ser 
            420                 425                 430         


Leu Asp Thr Gly Trp Val Ala Gly Leu Phe Tyr Tyr His Lys Phe Asn 
        435                 440                 445             


Ser Ser Gly Cys Pro Glu Arg Met Ala Ser Cys Lys Pro Leu Ala Asp 
    450                 455                 460                 


Phe Asp Gln Gly Trp Gly Pro Ile Arg His Ala Asn Gly Ser Gly Pro 
465                 470                 475                 480 


Glu His Arg Pro Tyr Cys Trp His Tyr Pro Pro Lys Pro Cys Gly Ile 
                485                 490                 495     


Val Ser Ala Gln Thr Val Cys Gly Pro Val Tyr Cys Phe Thr Pro Ser 
            500                 505                 510         


Pro Val Val Val Gly Thr Thr Asn Arg Leu Gly Val Pro Thr Tyr Ser 
        515                 520                 525             


Trp Gly Thr Asn Asp Thr Asp Val Phe Val Leu Asn Asn Thr Arg Pro 
    530                 535                 540                 


Pro Leu Gly Asn Trp Phe Gly Cys Thr Trp Met Asn Ser Ser Gly Phe 
545                 550                 555                 560 


Thr Lys Val Cys Gly Ala Pro Pro Cys Val Ile Gly Gly Val Gly Asn 
                565                 570                 575     


Asn Thr Leu His Cys Pro Thr Asp Cys Phe Arg Lys His Pro Glu Ala 
            580                 585                 590         


Thr Tyr Ser Arg Cys Gly Ser Gly Pro Trp Ile Thr Pro Arg Cys Leu 
        595                 600                 605             


Val His Tyr Pro Tyr Arg Leu Trp His Tyr Pro Cys Thr Val Asn Tyr 
    610                 615                 620                 


Thr Leu Phe Lys Val Arg Met Tyr Val Gly Gly Val Glu His Arg Leu 
625                 630                 635                 640 


Glu Val Ala Cys Asn Trp Thr Arg Gly Glu Arg Cys Asp Leu Asp Asp 
                645                 650                 655     


Arg Asp Arg Ser Glu Leu Ser Pro Leu Leu Leu Ser Thr Thr Gln Trp 
            660                 665                 670         


Gln Val Leu Pro Cys Ser Phe Thr Thr Leu Pro Ala Leu Thr Thr Gly 
        675                 680                 685             


Leu Ile His Leu His Gln Asn Ile Val Asp Val Gln Tyr Leu Tyr Gly 
    690                 695                 700                 


Val Gly Ser Ser Ile Val Ser Trp Ala Ile Lys Trp Glu Tyr Val Ile 
705                 710                 715                 720 


Leu Leu Phe Leu Leu Leu Ala Asp Ala Arg Ile Cys Ser Cys Leu Trp 
                725                 730                 735     


Met Met Leu Leu Ile Ser Gln Ala Glu Ala 
            740                 745     


<210>  8
<211>  746
<212>  PRT
<213>  Hepatitis C virus

<400>  8

Met Ser Thr Asn Pro Lys Pro Gln Arg Lys Thr Lys Arg Asn Thr Asn 
1               5                   10                  15      


Arg Arg Pro Gln Asp Val Lys Phe Pro Gly Gly Gly Gln Ile Val Gly 
            20                  25                  30          


Gly Val Tyr Leu Leu Pro Arg Arg Gly Pro Arg Leu Gly Val Arg Thr 
        35                  40                  45              


Thr Arg Lys Thr Ser Glu Arg Ser Glu Pro Arg Gly Arg Arg Gln Pro 
    50                  55                  60                  


Ile Pro Lys Ala Arg Arg Pro Glu Gly Arg Thr Trp Ala Gln Pro Gly 
65                  70                  75                  80  


Tyr Pro Trp Pro Leu Tyr Gly Asn Glu Gly Cys Gly Trp Ala Gly Trp 
                85                  90                  95      


Leu Leu Ser Pro Arg Gly Ser Arg Pro Ser Trp Gly Pro Thr Asp Pro 
            100                 105                 110         


Arg Arg Arg Ser Arg Asn Leu Gly Lys Val Ile Asp Thr Leu Thr Cys 
        115                 120                 125             


Gly Phe Ala Asp Leu Met Gly Tyr Ile Pro Leu Val Gly Ala Pro Leu 
    130                 135                 140                 


Gly Gly Ala Ala Arg Ala Leu Ala His Gly Val Arg Val Leu Glu Asp 
145                 150                 155                 160 


Gly Val Asn Tyr Ala Thr Gly Asn Leu Pro Gly Cys Ser Phe Ser Ile 
                165                 170                 175     


Phe Leu Leu Ala Leu Leu Ser Cys Leu Thr Val Pro Ala Ser Ala Tyr 
            180                 185                 190         


Gln Val Arg Asn Ser Ser Gly Leu Tyr His Val Thr Asn Asp Cys Pro 
        195                 200                 205             


Asn Ser Ser Ile Val Tyr Glu Thr Lys Asp Thr Ile Leu His Ser Pro 
    210                 215                 220                 


Gly Cys Val Pro Cys Val Arg Glu Gly Asn Val Ser Lys Cys Trp Val 
225                 230                 235                 240 


Pro Val Ala Leu Thr Val Ala Thr Arg Asp Gly Asn Leu Pro Thr Thr 
                245                 250                 255     


Gln Leu Arg Arg His Ile Asp Leu Leu Val Gly Ser Ala Thr Leu Cys 
            260                 265                 270         


Ser Ala Leu Tyr Val Gly Asp Leu Cys Gly Ser Val Phe Leu Val Gly 
        275                 280                 285             


Gln Leu Phe Thr Phe Ser Pro Arg Arg His Trp Thr Thr Gln Asp Cys 
    290                 295                 300                 


Asn Cys Ser Met Tyr Pro Gly His Ile Thr Gly His Arg Met Ala Trp 
305                 310                 315                 320 


Asp Met Met Met Asn Trp Ser Pro Thr Ser Ala Leu Val Val Ala Gln 
                325                 330                 335     


Leu Leu Arg Val Pro Gln Ala Ile Leu Asp Met Ile Ala Gly Ala His 
            340                 345                 350         


Trp Gly Val Leu Ala Gly Leu Ala Tyr Phe Ser Met Val Gly Asn Trp 
        355                 360                 365             


Ala Lys Val Leu Val Val Leu Leu Leu Phe Ala Ser Val Asp Ala Gly 
    370                 375                 380                 


Thr His Val Thr Gly Gly Ser Ala Ala His Asp Val Ser Ala Leu Ala 
385                 390                 395                 400 


Gly Phe Phe Arg Arg Gly Ala Lys Gln Asn Ile Gln Leu Ile Asn Thr 
                405                 410                 415     


Asn Gly Ser Trp His Val Asn Arg Thr Ala Leu Asn Cys Asn Ala Ser 
            420                 425                 430         


Leu Asp Thr Gly Trp Val Ala Gly Leu Leu Tyr Tyr His Arg Phe Asn 
        435                 440                 445             


Ser Ser Gly Cys Pro Glu Arg Met Ala Ser Cys Arg Pro Leu Ala Asp 
    450                 455                 460                 


Phe Asp Gln Gly Trp Gly Pro Ile Thr Asn Val Asp Gly Gly Gly Ser 
465                 470                 475                 480 


Glu Tyr Arg Pro Tyr Cys Trp His Tyr Pro Pro Lys Pro Cys Gly Ile 
                485                 490                 495     


Glu Pro Ala Gln Asn Val Cys Gly Pro Val Tyr Cys Phe Thr Pro Ser 
            500                 505                 510         


Pro Val Val Val Gly Thr Thr Asp Lys Val Gly Val Pro Thr Tyr Asn 
        515                 520                 525             


Trp Gly Glu Asn Asp Thr Asp Val Phe Val Leu Asn Asn Thr Arg Pro 
    530                 535                 540                 


Pro Leu Gly Asn Trp Phe Gly Cys Thr Trp Met Asn Ser Ser Gly Phe 
545                 550                 555                 560 


Val Lys Val Cys Gly Ala Pro Pro Cys Ile Ile Gly Gly Ala Gly Asn 
                565                 570                 575     


Lys Thr Leu His Cys Pro Thr Asp Cys Phe Arg Lys His Pro Asp Ala 
            580                 585                 590         


Thr Tyr Ser Arg Cys Gly Ser Gly Pro Trp Leu Thr Pro Arg Cys Leu 
        595                 600                 605             


Val Asp Tyr Pro Tyr Arg Leu Trp His Tyr Pro Cys Thr Val Asn Tyr 
    610                 615                 620                 


Thr Leu Phe Lys Ile Arg Met Tyr Val Gly Gly Val Glu His Arg Leu 
625                 630                 635                 640 


Val Ala Ala Cys Asn Trp Thr Tyr Gly Glu Arg Cys Asn Leu Asp Asp 
                645                 650                 655     


Arg Asp Arg Ser Glu Leu Ser Pro Leu Leu Leu Ser Thr Thr Gln Trp 
            660                 665                 670         


Gln Val Leu Pro Cys Ser Phe Thr Thr Leu Pro Ala Leu Thr Thr Gly 
        675                 680                 685             


Leu Ile His Leu His Gln Asn Ile Val Asp Val Gln Tyr Leu Tyr Gly 
    690                 695                 700                 


Val Gly Ser Ser Ile Val Ser Trp Ala Ile Lys Trp Glu Tyr Val Ile 
705                 710                 715                 720 


Leu Leu Phe Leu Leu Leu Ala Asp Ala Arg Ile Cys Ser Cys Leu Trp 
                725                 730                 735     


Met Met Leu Leu Ile Ser Gln Ala Glu Ala 
            740                 745     


<210>  9
<211>  746
<212>  PRT
<213>  Hepatitis C virus

<400>  9

Met Ser Thr Asn Pro Lys Pro Gln Arg Lys Thr Lys Arg Asn Thr Asn 
1               5                   10                  15      


Arg Arg Pro Gln Asp Val Lys Phe Pro Gly Gly Gly Gln Ile Val Gly 
            20                  25                  30          


Gly Val Tyr Leu Leu Pro Arg Arg Gly Pro Arg Leu Gly Val Arg Ala 
        35                  40                  45              


Thr Arg Lys Thr Ser Glu Arg Ser Gln Pro Arg Gly Arg Arg Gln Pro 
    50                  55                  60                  


Ile Pro Lys Ala Arg Arg Pro Glu Gly Arg Thr Trp Ala Gln Pro Gly 
65                  70                  75                  80  


Tyr Pro Trp Pro Leu Tyr Gly Asn Glu Gly Cys Gly Trp Ala Gly Trp 
                85                  90                  95      


Leu Leu Ser Pro Arg Gly Ser Arg Pro Ser Trp Gly Pro Thr Asp Pro 
            100                 105                 110         


Arg Arg Arg Ser Arg Asn Leu Gly Lys Val Ile Asp Thr Leu Thr Cys 
        115                 120                 125             


Gly Phe Ala Asp Leu Met Gly Tyr Ile Pro Leu Val Gly Ala Pro Leu 
    130                 135                 140                 


Gly Gly Ala Ala Arg Ala Leu Ala His Gly Val Arg Val Leu Glu Asp 
145                 150                 155                 160 


Gly Val Asn Tyr Ala Thr Gly Asn Leu Pro Gly Cys Ser Phe Ser Ile 
                165                 170                 175     


Phe Leu Leu Ala Leu Leu Ser Cys Leu Thr Val Pro Ala Ser Ala Tyr 
            180                 185                 190         


Gln Val Arg Asn Ser Ser Gly Leu Tyr His Val Thr Asn Asp Cys Pro 
        195                 200                 205             


Asn Ser Ser Ile Val Tyr Glu Thr Ala Asp Thr Ile Leu His Ser Pro 
    210                 215                 220                 


Gly Cys Val Pro Cys Val Arg Glu Gly Asn Ala Ser Lys Cys Trp Val 
225                 230                 235                 240 


Ala Val Ala Pro Thr Val Ala Thr Arg Asp Gly Thr Leu Pro Thr Thr 
                245                 250                 255     


Gln Leu Arg Arg His Ile Asp Leu Leu Val Gly Gly Ala Thr Leu Cys 
            260                 265                 270         


Ser Ala Leu Tyr Val Gly Asp Leu Cys Gly Ser Val Phe Leu Val Gly 
        275                 280                 285             


Gln Leu Phe Thr Phe Ser Pro Arg Arg His Trp Thr Thr Gln Asp Cys 
    290                 295                 300                 


Asn Cys Ser Ile Tyr Pro Gly His Ile Thr Gly His Arg Met Ala Trp 
305                 310                 315                 320 


Asp Met Met Met Asn Trp Ser Pro Thr Thr Ala Leu Ile Val Ala Gln 
                325                 330                 335     


Leu Leu Arg Val Pro Gln Ala Ile Leu Asp Met Ile Ala Gly Ala His 
            340                 345                 350         


Trp Gly Val Leu Ala Gly Ile Ala Tyr Phe Ser Met Val Gly Asn Trp 
        355                 360                 365             


Ala Lys Val Leu Val Val Leu Leu Leu Phe Ala Gly Val Asp Ala Glu 
    370                 375                 380                 


Thr His Val Thr Gly Gly Ser Ala Ala Gln Val Thr Ser Arg Val Ala 
385                 390                 395                 400 


Gly Phe Phe Asn Pro Gly Pro Lys Gln Asn Val Gln Leu Ile Asn Thr 
                405                 410                 415     


Asn Gly Ser Trp His Ile Asn Arg Thr Ala Leu Asn Cys Asn Ala Ser 
            420                 425                 430         


Leu Asp Thr Gly Trp Val Ala Gly Leu Phe Tyr His Tyr Asn Phe Asn 
        435                 440                 445             


Ser Ser Gly Cys Pro Glu Arg Met Ala Ser Cys Arg Pro Leu Ala Asp 
    450                 455                 460                 


Phe Asp Gln Gly Trp Gly Pro Ile Ser Tyr Ala Asn Gly Ser Gly Pro 
465                 470                 475                 480 


Glu His Arg Pro Tyr Cys Trp His Tyr Pro Pro Lys Pro Cys Gly Ile 
                485                 490                 495     


Val Pro Ala Gln Asn Val Cys Gly Pro Val Tyr Cys Phe Thr Pro Ser 
            500                 505                 510         


Pro Val Val Val Gly Thr Thr Asn Arg Leu Gly Val Pro Thr Tyr Asn 
        515                 520                 525             


Trp Gly Ser Asn Asp Thr Asp Val Phe Val Leu Asn Asn Thr Arg Pro 
    530                 535                 540                 


Pro Leu Gly Asn Trp Phe Gly Cys Thr Trp Met Asn Ser Ser Gly Phe 
545                 550                 555                 560 


Thr Lys Val Cys Gly Ala Pro Pro Cys Val Ile Gly Gly Val Gly Asn 
                565                 570                 575     


Asn Thr Leu His Cys Pro Thr Asp Cys Phe Arg Lys His Pro Glu Ala 
            580                 585                 590         


Thr Tyr Ser Arg Cys Gly Ser Gly Pro Trp Ile Thr Pro Arg Cys Leu 
        595                 600                 605             


Val His Tyr Pro Tyr Arg Leu Trp His Tyr Pro Cys Thr Val Asn Tyr 
    610                 615                 620                 


Thr Leu Phe Lys Val Arg Met Tyr Val Gly Gly Val Glu His Arg Leu 
625                 630                 635                 640 


Glu Ala Ala Cys Asn Trp Thr Arg Gly Glu Arg Cys Asp Leu Asp Asp 
                645                 650                 655     


Arg Asp Arg Ser Glu Leu Ser Pro Leu Leu Leu Ser Thr Thr Gln Trp 
            660                 665                 670         


Gln Val Leu Pro Cys Ser Phe Thr Thr Leu Pro Ala Leu Thr Thr Gly 
        675                 680                 685             


Leu Ile His Leu His Gln Asn Ile Val Asp Val Gln Tyr Leu Tyr Gly 
    690                 695                 700                 


Val Gly Ser Ser Ile Val Ser Trp Ala Ile Lys Trp Glu Tyr Val Ile 
705                 710                 715                 720 


Leu Leu Phe Leu Leu Leu Ala Asp Ala Arg Ile Cys Ser Cys Leu Trp 
                725                 730                 735     


Met Met Leu Leu Ile Ser Gln Ala Glu Ala 
            740                 745     


<210>  10
<211>  746
<212>  PRT
<213>  Hepatitis C virus

<400>  10

Met Ser Thr Asn Pro Lys Pro Gln Arg Lys Thr Lys Arg Asn Thr Asn 
1               5                   10                  15      


Arg Arg Pro Gln Asp Val Lys Phe Pro Gly Gly Gly Gln Ile Val Gly 
            20                  25                  30          


Gly Val Tyr Leu Leu Pro Arg Arg Gly Pro Arg Leu Gly Val Arg Ala 
        35                  40                  45              


Thr Arg Lys Thr Ser Glu Arg Ser Gln Pro Arg Gly Arg Arg Gln Pro 
    50                  55                  60                  


Ile Pro Lys Ala Arg Arg Pro Glu Gly Arg Ser Trp Ala Gln Pro Gly 
65                  70                  75                  80  


Tyr Pro Trp Pro Leu Tyr Gly Asn Glu Gly Cys Gly Trp Ala Gly Trp 
                85                  90                  95      


Leu Leu Ser Pro Arg Gly Ser Arg Pro Ser Trp Gly Pro Thr Asp Pro 
            100                 105                 110         


Arg Arg Arg Ser Arg Asn Leu Gly Lys Val Ile Asp Thr Leu Thr Cys 
        115                 120                 125             


Gly Phe Ala Asp Leu Met Gly Tyr Ile Pro Leu Val Gly Ala Pro Leu 
    130                 135                 140                 


Gly Gly Ala Ala Arg Ala Leu Ala His Gly Val Arg Val Leu Glu Asp 
145                 150                 155                 160 


Gly Val Asn Tyr Ala Thr Gly Asn Leu Pro Gly Cys Ser Phe Ser Ile 
                165                 170                 175     


Phe Leu Leu Ala Leu Leu Ser Cys Leu Thr Val Pro Ala Ser Ala Tyr 
            180                 185                 190         


Gln Val Arg Asn Ser Ser Gly Ile Tyr His Val Thr Asn Asp Cys Pro 
        195                 200                 205             


Asn Ser Ser Ile Val Tyr Glu Thr Ala Asp Thr Ile Leu His Ser Pro 
    210                 215                 220                 


Gly Cys Val Pro Cys Val Arg Glu Gly Asn Ala Ser Lys Cys Trp Val 
225                 230                 235                 240 


Ala Leu Ala Pro Thr Val Ala Thr Arg Asp Gly Arg Leu Pro Thr Thr 
                245                 250                 255     


Gln Leu Arg Arg His Ile Asp Leu Leu Val Gly Ser Ala Thr Leu Cys 
            260                 265                 270         


Ser Ala Leu Tyr Val Gly Asp Leu Cys Gly Ser Val Phe Leu Val Gly 
        275                 280                 285             


Gln Leu Phe Thr Phe Ser Pro Arg Arg His Trp Thr Thr Gln Asp Cys 
    290                 295                 300                 


Asn Cys Ser Ile Tyr Pro Gly His Ile Thr Gly His Arg Met Ala Trp 
305                 310                 315                 320 


Asp Met Met Met Asn Trp Ser Pro Thr Thr Ala Leu Val Val Ala Gln 
                325                 330                 335     


Leu Leu Arg Ile Pro Gln Ala Ile Leu Asp Met Ile Ala Gly Ala His 
            340                 345                 350         


Trp Gly Val Leu Ala Gly Ile Ala Tyr Phe Ser Met Val Gly Asn Trp 
        355                 360                 365             


Ala Lys Val Leu Val Val Leu Leu Leu Phe Ala Gly Val Asp Ala His 
    370                 375                 380                 


Thr Arg Val Thr Gly Gly Ser Ala Ala Arg Ala Thr Ala Arg Leu Thr 
385                 390                 395                 400 


Thr Leu Phe Ser Pro Gly Ala Lys Gln Asp Ile Gln Leu Ile Asn Thr 
                405                 410                 415     


Asn Gly Ser Trp His Ile Asn Arg Thr Ala Leu Asn Cys Asn Ala Ser 
            420                 425                 430         


Leu Asp Thr Gly Trp Val Ala Gly Leu Phe Tyr Tyr His Lys Phe Asn 
        435                 440                 445             


Ser Ser Gly Cys Pro Glu Arg Met Ala Ser Cys Arg Pro Leu Ala Asp 
    450                 455                 460                 


Phe Asp Gln Gly Trp Gly Pro Ile Ser Tyr Ala Asn Gly Ser Gly Pro 
465                 470                 475                 480 


Glu His Arg Pro Tyr Cys Trp His Tyr Pro Pro Lys Pro Cys Gly Ile 
                485                 490                 495     


Ile Pro Ala Lys Thr Val Cys Gly Pro Val Tyr Cys Phe Thr Pro Ser 
            500                 505                 510         


Pro Val Val Val Gly Thr Thr Asp Arg Ser Gly Ala Pro Thr Phe Asn 
        515                 520                 525             


Trp Gly Asp Asn Asp Thr Asp Val Leu Val Leu Asn Asn Thr Arg Pro 
    530                 535                 540                 


Pro Leu Gly Asn Trp Phe Gly Cys Thr Trp Met Asn Ser Ser Gly Tyr 
545                 550                 555                 560 


Thr Lys Val Cys Gly Ala Pro Pro Cys Ile Ile Gly Gly Val Gly Asn 
                565                 570                 575     


Asn Thr Leu His Cys Pro Thr Asp Cys Phe Arg Lys His Pro Glu Ala 
            580                 585                 590         


Thr Tyr Ser Arg Cys Gly Ser Gly Pro Trp Ile Thr Pro Arg Cys Leu 
        595                 600                 605             


Val His Tyr Pro Tyr Arg Leu Trp His Tyr Pro Cys Thr Val Asn Tyr 
    610                 615                 620                 


Thr Leu Phe Lys Val Arg Met Tyr Val Gly Gly Val Glu His Arg Leu 
625                 630                 635                 640 


Glu Ala Ala Cys Asn Trp Thr Arg Gly Glu Arg Cys Asn Leu Asp Asp 
                645                 650                 655     


Arg Asp Arg Ser Glu Leu Ser Pro Leu Leu Leu Ser Thr Thr Gln Trp 
            660                 665                 670         


Gln Val Leu Pro Cys Ser Phe Thr Thr Leu Pro Ala Leu Thr Thr Gly 
        675                 680                 685             


Leu Ile His Leu His Gln Asn Ile Val Asp Val Gln Tyr Leu Tyr Gly 
    690                 695                 700                 


Val Gly Ser Ser Ile Val Ser Trp Ala Ile Lys Trp Glu Tyr Val Ile 
705                 710                 715                 720 


Leu Leu Phe Leu Leu Leu Ala Asp Ala Arg Val Cys Ser Cys Leu Trp 
                725                 730                 735     


Met Met Leu Leu Ile Ser Gln Val Glu Ala 
            740                 745     


<210>  11
<211>  746
<212>  PRT
<213>  Hepatitis C virus

<400>  11

Met Ser Thr Asn Pro Lys Pro Gln Arg Lys Thr Lys Arg Asn Thr Asn 
1               5                   10                  15      


Arg Arg Pro Gln Asp Val Lys Phe Pro Gly Gly Gly Gln Ile Val Gly 
            20                  25                  30          


Gly Val Tyr Leu Leu Pro Arg Arg Gly Pro Arg Leu Gly Val Arg Ala 
        35                  40                  45              


Thr Arg Lys Thr Ser Glu Arg Ser Gln Pro Arg Gly Arg Arg Gln Pro 
    50                  55                  60                  


Ile Pro Lys Ala Arg Arg Pro Glu Gly Arg Thr Trp Ala Gln Pro Gly 
65                  70                  75                  80  


Tyr Pro Trp Pro Leu Tyr Gly Asn Glu Gly Cys Gly Trp Ala Gly Trp 
                85                  90                  95      


Leu Leu Ser Pro Arg Gly Ser Arg Pro Ser Trp Gly Pro Thr Asp Pro 
            100                 105                 110         


Arg Arg Arg Ser Arg Asn Leu Gly Lys Val Ile Asp Thr Leu Thr Cys 
        115                 120                 125             


Gly Phe Ala Asp Leu Met Gly Tyr Ile Pro Leu Val Gly Ala Pro Leu 
    130                 135                 140                 


Gly Gly Ala Ala Arg Ala Leu Ala His Gly Val Arg Val Leu Glu Asp 
145                 150                 155                 160 


Gly Val Asn Tyr Ala Thr Gly Asn Leu Pro Gly Cys Ser Phe Ser Ile 
                165                 170                 175     


Phe Leu Leu Ala Leu Leu Ser Cys Leu Thr Val Pro Ala Ser Ala Tyr 
            180                 185                 190         


Gln Val Arg Asn Ser Ser Gly Leu Tyr His Val Thr Asn Asp Cys Pro 
        195                 200                 205             


Asn Ser Ser Ile Val Tyr Glu Thr Ala Asp Thr Ile Leu His Ser Pro 
    210                 215                 220                 


Gly Cys Val Pro Cys Val Arg Glu Gly Asn Ala Ser Lys Cys Trp Val 
225                 230                 235                 240 


Ala Val Thr Pro Thr Val Ala Thr Arg Asp Gly Arg Leu Pro Ala Thr 
                245                 250                 255     


Gln Leu Arg Arg His Ile Asp Leu Leu Val Gly Ser Ala Thr Leu Cys 
            260                 265                 270         


Ser Ala Leu Tyr Val Gly Asp Leu Cys Gly Ser Ile Phe Leu Val Gly 
        275                 280                 285             


Gln Leu Phe Thr Phe Ser Pro Arg Arg His Trp Thr Thr Gln Asp Cys 
    290                 295                 300                 


Asn Cys Ser Ile Tyr Pro Gly His Ile Thr Gly His Arg Met Ala Trp 
305                 310                 315                 320 


Asp Met Met Met Asn Trp Ser Pro Thr Thr Ala Leu Val Val Ala Gln 
                325                 330                 335     


Leu Leu Arg Val Pro Gln Ala Ile Leu Asp Met Ile Ala Gly Ala His 
            340                 345                 350         


Trp Gly Val Leu Ala Gly Ile Ala Tyr Phe Ser Met Val Gly Asn Trp 
        355                 360                 365             


Ala Lys Val Leu Val Val Leu Leu Leu Phe Ala Gly Val Asp Ala Gly 
    370                 375                 380                 


Thr His Val Thr Gly Gly Ser Ala Ala Lys Asp Thr Ser Gly Phe Thr 
385                 390                 395                 400 


Ser Leu Phe Arg Ile Gly Ala Arg Gln Asn Ile Gln Leu Ile Asn Ser 
                405                 410                 415     


Asn Gly Ser Trp His Ile Asn Arg Thr Ala Leu Asn Cys Asn Glu Ser 
            420                 425                 430         


Leu Asp Thr Gly Trp Val Ala Gly Leu Leu Tyr Tyr His Lys Phe Asn 
        435                 440                 445             


Ser Ser Gly Cys Pro Glu Arg Met Ala Ser Cys Arg Ser Leu Ala Asp 
    450                 455                 460                 


Phe Asp Gln Gly Trp Gly Pro Ile Ser Tyr Ala Asn Gly Ser Gly Pro 
465                 470                 475                 480 


Glu His Arg Pro Tyr Cys Trp His Tyr Pro Pro Lys Pro Cys Gly Ile 
                485                 490                 495     


Val Pro Ala Gln Ser Val Cys Gly Pro Val Tyr Cys Phe Thr Pro Ser 
            500                 505                 510         


Pro Val Val Val Gly Thr Thr Asp Lys Ser Gly Ala Pro Thr Tyr Asn 
        515                 520                 525             


Trp Gly Cys Asn Glu Thr Asp Val Phe Val Leu Asn Asn Thr Arg Pro 
    530                 535                 540                 


Pro Leu Gly Asn Trp Phe Gly Cys Thr Trp Met Asn Ser Ser Gly Phe 
545                 550                 555                 560 


Thr Lys Val Cys Gly Ala Pro Pro Cys Val Ile Gly Gly Val Gly Asn 
                565                 570                 575     


Asn Thr Leu His Cys Pro Thr Asp Cys Phe Arg Lys His Pro Glu Ala 
            580                 585                 590         


Thr Tyr Ser Arg Cys Gly Ser Gly Pro Trp Ile Thr Pro Arg Cys Leu 
        595                 600                 605             


Val His Tyr Ala Tyr Arg Leu Trp His Tyr Pro Cys Thr Val Asn Tyr 
    610                 615                 620                 


Thr Leu Phe Lys Val Arg Met Tyr Val Gly Gly Val Glu His Arg Leu 
625                 630                 635                 640 


Asp Val Ala Cys Asn Trp Thr Arg Gly Glu Arg Cys Asn Leu Asp Asp 
                645                 650                 655     


Arg Asp Arg Ser Glu Leu Ser Pro Leu Leu Leu Ser Thr Thr Gln Trp 
            660                 665                 670         


Gln Val Leu Pro Cys Ser Phe Thr Thr Leu Pro Ala Leu Ser Thr Gly 
        675                 680                 685             


Leu Ile His Leu His Gln Asn Ile Val Asp Val Gln Tyr Leu Tyr Gly 
    690                 695                 700                 


Val Gly Ser Ser Ile Val Ser Trp Ala Ile Lys Trp Glu Tyr Val Ile 
705                 710                 715                 720 


Leu Leu Phe Leu Leu Leu Ala Asp Ala Arg Ile Cys Ser Cys Leu Trp 
                725                 730                 735     


Met Met Leu Leu Ile Ser Gln Ala Glu Ala 
            740                 745     


<210>  12
<211>  746
<212>  PRT
<213>  Hepatitis C virus

<400>  12

Met Ser Thr Asn Pro Lys Pro Gln Arg Lys Thr Lys Arg Asn Thr Asn 
1               5                   10                  15      


Arg Arg Pro Gln Asp Val Lys Phe Pro Gly Gly Gly Gln Ile Val Gly 
            20                  25                  30          


Gly Val Tyr Leu Leu Pro Arg Arg Gly Pro Arg Leu Gly Val Arg Ala 
        35                  40                  45              


Thr Arg Lys Thr Ser Glu Arg Ser Gln Pro Arg Gly Arg Arg Gln Pro 
    50                  55                  60                  


Ile Pro Lys Ala Arg Arg Pro Glu Gly Arg Thr Trp Ala Gln Pro Gly 
65                  70                  75                  80  


Tyr Pro Trp Pro Leu Tyr Gly Asn Glu Gly Cys Gly Trp Ala Gly Trp 
                85                  90                  95      


Leu Leu Ser Pro Arg Gly Ser Arg Pro Ser Trp Gly Pro Thr Asp Pro 
            100                 105                 110         


Arg Arg Arg Ser Arg Asn Leu Gly Lys Val Ile Asp Thr Leu Thr Cys 
        115                 120                 125             


Gly Phe Ala Asp Leu Met Gly Tyr Ile Pro Leu Val Gly Ala Pro Leu 
    130                 135                 140                 


Gly Gly Ala Ala Arg Ala Leu Ala His Gly Val Arg Val Leu Glu Asp 
145                 150                 155                 160 


Gly Val Asn Tyr Ala Thr Gly Asn Leu Pro Gly Cys Ser Phe Ser Ile 
                165                 170                 175     


Phe Leu Leu Ala Leu Leu Ser Cys Leu Thr Val Pro Ala Ser Ala Tyr 
            180                 185                 190         


Gln Val Arg Asn Ser Ser Gly Leu Tyr His Val Thr Asn Asp Cys Pro 
        195                 200                 205             


Asn Ser Ser Ile Val Tyr Glu Thr Ala Asp Thr Ile Leu His Ser Pro 
    210                 215                 220                 


Gly Cys Val Pro Cys Val Arg Glu Gly Asn Ala Ser Lys Cys Trp Val 
225                 230                 235                 240 


Ala Val Thr Pro Thr Val Ala Thr Arg Asp Gly Arg Leu Pro Ala Thr 
                245                 250                 255     


Gln Leu Arg Arg His Ile Asp Leu Leu Val Gly Ser Ala Thr Leu Cys 
            260                 265                 270         


Ser Ala Leu Tyr Val Gly Asp Leu Cys Gly Ser Ile Phe Leu Val Gly 
        275                 280                 285             


Gln Leu Phe Thr Phe Ser Pro Arg Arg His Trp Thr Thr Gln Asp Cys 
    290                 295                 300                 


Asn Cys Ser Ile Tyr Pro Gly His Ile Thr Gly His Arg Met Ala Trp 
305                 310                 315                 320 


Asp Met Met Met Asn Trp Ser Pro Thr Thr Ala Leu Val Val Ala Gln 
                325                 330                 335     


Leu Leu Arg Val Pro Gln Ala Ile Leu Asp Met Ile Ala Gly Ala His 
            340                 345                 350         


Trp Gly Val Leu Ala Gly Ile Ala Tyr Phe Ser Met Val Gly Asn Trp 
        355                 360                 365             


Ala Lys Val Leu Val Val Leu Leu Leu Phe Ala Gly Val Asp Ala Gly 
    370                 375                 380                 


Thr His Val Thr Gly Gly Ser Ala Ala Lys Asp Thr Ser Gly Phe Thr 
385                 390                 395                 400 


Ser Leu Phe Arg Ile Gly Ala Arg Gln Asn Ile Gln Leu Ile Asn Ser 
                405                 410                 415     


Asn Gly Ser Trp His Ile Asn Arg Thr Ala Leu Asn Cys Asn Glu Ser 
            420                 425                 430         


Leu Asp Thr Gly Trp Val Ala Gly Leu Leu Tyr Tyr His Lys Phe Asn 
        435                 440                 445             


Ser Ser Gly Cys Pro Glu Arg Met Ala Ser Cys Arg Ser Leu Ala Asp 
    450                 455                 460                 


Phe Asp Gln Gly Trp Gly Pro Ile Ser Tyr Ala Asn Gly Ser Gly Pro 
465                 470                 475                 480 


Glu His Arg Pro Tyr Cys Trp His Tyr Pro Pro Lys Pro Cys Gly Ile 
                485                 490                 495     


Val Pro Ala Gln Ser Val Cys Gly Pro Val Tyr Cys Phe Thr Pro Ser 
            500                 505                 510         


Pro Val Val Val Gly Thr Thr Asp Lys Ser Gly Ala Pro Thr Tyr Asn 
        515                 520                 525             


Trp Gly Cys Asn Glu Thr Asp Val Phe Val Leu Asn Asn Thr Arg Pro 
    530                 535                 540                 


Pro Leu Gly Asn Trp Phe Gly Cys Thr Trp Met Asn Ser Ser Gly Phe 
545                 550                 555                 560 


Thr Lys Val Cys Gly Ala Pro Pro Cys Val Ile Gly Gly Val Gly Asn 
                565                 570                 575     


Asn Thr Leu His Cys Pro Thr Asp Cys Phe Arg Lys His Pro Glu Ala 
            580                 585                 590         


Thr Tyr Ser Arg Cys Gly Ser Gly Pro Trp Ile Thr Pro Arg Cys Leu 
        595                 600                 605             


Val His Tyr Ala Tyr Arg Leu Trp His Tyr Pro Cys Thr Val Asn Tyr 
    610                 615                 620                 


Thr Leu Phe Lys Val Arg Met Tyr Val Gly Gly Val Glu His Arg Leu 
625                 630                 635                 640 


Asp Val Ala Cys Asn Trp Thr Arg Gly Glu Arg Cys Asn Leu Asp Asp 
                645                 650                 655     


Arg Asp Arg Ser Glu Leu Ser Pro Leu Leu Leu Ser Thr Thr Gln Trp 
            660                 665                 670         


Gln Val Leu Pro Cys Ser Phe Thr Thr Leu Pro Ala Leu Ser Thr Gly 
        675                 680                 685             


Leu Ile His Leu His Gln Asn Ile Val Asp Val Gln Tyr Leu Tyr Gly 
    690                 695                 700                 


Val Gly Ser Ser Ile Val Ser Trp Ala Ile Lys Trp Glu Tyr Val Ile 
705                 710                 715                 720 


Leu Leu Phe Leu Leu Leu Ala Asp Ala Arg Ile Cys Ser Cys Leu Trp 
                725                 730                 735     


Met Met Leu Leu Ile Ser Gln Ala Glu Ala 
            740                 745     


<210>  13
<211>  746
<212>  PRT
<213>  Hepatitis C virus

<400>  13

Met Ser Thr Asn Pro Lys Pro Gln Arg Lys Thr Lys Arg Asn Thr Asn 
1               5                   10                  15      


Arg Arg Pro Gln Asp Val Lys Phe Pro Gly Gly Gly Gln Ile Val Gly 
            20                  25                  30          


Gly Val Tyr Leu Leu Pro Arg Arg Gly Pro Arg Leu Gly Val Arg Ala 
        35                  40                  45              


Thr Arg Lys Thr Ser Glu Arg Ser Gln Pro Arg Gly Arg Arg Gln Pro 
    50                  55                  60                  


Ile Pro Lys Ala Arg Arg Pro Glu Gly Arg Thr Trp Ala Gln Pro Gly 
65                  70                  75                  80  


Tyr Pro Trp Pro Leu Tyr Gly Asn Glu Gly Cys Gly Trp Ala Gly Trp 
                85                  90                  95      


Leu Leu Ser Pro Arg Gly Ser Arg Pro Ser Trp Gly Pro Thr Asp Pro 
            100                 105                 110         


Arg Arg Arg Ser Arg Asn Leu Gly Lys Val Ile Asp Thr Leu Thr Cys 
        115                 120                 125             


Gly Phe Ala Asp Leu Met Gly Tyr Ile Pro Leu Val Gly Ala Pro Leu 
    130                 135                 140                 


Gly Gly Ala Ala Arg Ala Leu Ala His Gly Val Arg Val Leu Glu Asp 
145                 150                 155                 160 


Gly Val Asn Tyr Ala Thr Gly Asn Leu Pro Gly Cys Ser Phe Ser Ile 
                165                 170                 175     


Phe Leu Leu Ala Leu Leu Ser Cys Leu Thr Val Pro Ala Ser Ala Tyr 
            180                 185                 190         


Gln Val Arg Asn Ser Ser Gly Leu Tyr His Val Thr Asn Asp Cys Pro 
        195                 200                 205             


Asn Ser Ser Ile Val Tyr Glu Thr Ala Asp Thr Ile Leu His Ser Pro 
    210                 215                 220                 


Gly Cys Val Pro Cys Val Arg Glu Gly Asn Ala Ser Lys Cys Trp Val 
225                 230                 235                 240 


Ala Val Thr Pro Thr Val Ala Thr Arg Asp Gly Arg Leu Pro Ala Thr 
                245                 250                 255     


Gln Leu Arg Arg His Ile Asp Leu Leu Val Gly Ser Ala Thr Leu Cys 
            260                 265                 270         


Ser Ala Leu Tyr Val Gly Asp Leu Cys Gly Ser Ile Phe Leu Val Gly 
        275                 280                 285             


Gln Leu Phe Thr Phe Ser Pro Arg Arg His Trp Thr Thr Gln Asp Cys 
    290                 295                 300                 


Asn Cys Ser Ile Tyr Pro Gly His Ile Thr Gly His Arg Met Ala Trp 
305                 310                 315                 320 


Asp Met Met Met Asn Trp Ser Pro Thr Thr Ala Leu Val Val Ala Gln 
                325                 330                 335     


Leu Leu Arg Val Pro Gln Ala Ile Leu Asp Met Ile Ala Gly Ala His 
            340                 345                 350         


Trp Gly Val Leu Ala Gly Ile Ala Tyr Phe Ser Met Val Gly Asn Trp 
        355                 360                 365             


Ala Lys Val Leu Val Val Leu Leu Leu Phe Ala Gly Val Asp Ala Gly 
    370                 375                 380                 


Thr His Val Thr Gly Gly Ser Ala Ala Lys Asp Thr Ser Gly Phe Thr 
385                 390                 395                 400 


Ser Leu Phe Arg Ile Gly Ala Arg Gln Asn Ile Gln Leu Ile Asn Ser 
                405                 410                 415     


Asn Gly Ser Trp His Ile Asn Arg Thr Ala Leu Asn Cys Asn Glu Ser 
            420                 425                 430         


Leu Asp Thr Gly Trp Val Ala Gly Leu Leu Tyr Tyr His Lys Phe Asn 
        435                 440                 445             


Ser Ser Gly Cys Pro Glu Arg Met Ala Ser Cys Arg Ser Leu Ala Asp 
    450                 455                 460                 


Phe Asp Gln Gly Trp Gly Pro Ile Ser Tyr Ala Asn Gly Ser Gly Pro 
465                 470                 475                 480 


Glu His Arg Pro Tyr Cys Trp His Tyr Pro Pro Lys Pro Cys Gly Ile 
                485                 490                 495     


Val Pro Ala Gln Ser Val Cys Gly Pro Val Tyr Cys Phe Thr Pro Ser 
            500                 505                 510         


Pro Val Val Val Gly Thr Thr Asp Lys Ser Gly Ala Pro Thr Tyr Asn 
        515                 520                 525             


Trp Gly Cys Asn Glu Thr Asp Val Phe Val Leu Asn Asn Thr Arg Pro 
    530                 535                 540                 


Pro Leu Gly Asn Trp Phe Gly Cys Thr Trp Met Asn Ser Ser Gly Phe 
545                 550                 555                 560 


Thr Lys Val Cys Gly Ala Pro Pro Cys Val Ile Gly Gly Val Gly Asn 
                565                 570                 575     


Asn Thr Leu His Cys Pro Thr Asp Cys Phe Arg Lys His Pro Glu Ala 
            580                 585                 590         


Thr Tyr Ser Arg Cys Gly Ser Gly Pro Trp Ile Thr Pro Arg Cys Leu 
        595                 600                 605             


Val His Tyr Ala Tyr Arg Leu Trp His Tyr Pro Cys Thr Val Asn Tyr 
    610                 615                 620                 


Thr Leu Phe Lys Val Arg Met Tyr Val Gly Gly Val Glu His Arg Leu 
625                 630                 635                 640 


Asp Val Ala Cys Asn Trp Thr Arg Gly Glu Arg Cys Asn Leu Asp Asp 
                645                 650                 655     


Arg Asp Arg Ser Glu Leu Ser Pro Leu Leu Leu Ser Thr Thr Gln Trp 
            660                 665                 670         


Gln Val Leu Pro Cys Ser Phe Thr Thr Leu Pro Ala Leu Ser Thr Gly 
        675                 680                 685             


Leu Ile His Leu His Gln Asn Ile Val Asp Val Gln Tyr Leu Tyr Gly 
    690                 695                 700                 


Val Gly Ser Ser Ile Val Ser Trp Ala Ile Lys Trp Glu Tyr Val Ile 
705                 710                 715                 720 


Leu Leu Phe Leu Leu Leu Ala Asp Ala Arg Ile Cys Ser Cys Leu Trp 
                725                 730                 735     


Met Met Leu Leu Ile Ser Gln Ala Glu Ala 
            740                 745     


<210>  14
<211>  746
<212>  PRT
<213>  Hepatitis C virus

<400>  14

Met Ser Thr Asn Pro Lys Pro Gln Arg Lys Thr Lys Arg Asn Thr Asn 
1               5                   10                  15      


Arg Arg Pro Gln Asp Val Lys Phe Pro Gly Gly Gly Gln Ile Val Gly 
            20                  25                  30          


Gly Val Tyr Leu Leu Pro Arg Arg Gly Pro Arg Leu Gly Val Arg Ala 
        35                  40                  45              


Thr Arg Lys Thr Ser Glu Arg Ser Gln Pro Arg Gly Arg Arg Gln Pro 
    50                  55                  60                  


Ile Pro Lys Ala Arg Arg Pro Glu Gly Arg Thr Trp Ala Gln Pro Gly 
65                  70                  75                  80  


Tyr Pro Trp Pro Leu Tyr Gly Asn Glu Gly Cys Gly Trp Ala Gly Trp 
                85                  90                  95      


Leu Leu Ser Pro Arg Gly Ser Arg Pro Ser Trp Gly Pro Thr Asp Pro 
            100                 105                 110         


Arg Arg Arg Ser Arg Asn Leu Gly Lys Val Ile Asp Thr Leu Thr Cys 
        115                 120                 125             


Gly Phe Ala Asp Leu Met Gly Tyr Ile Pro Leu Val Gly Ala Pro Leu 
    130                 135                 140                 


Gly Gly Ala Ala Arg Ala Leu Ala His Gly Val Arg Val Leu Glu Asp 
145                 150                 155                 160 


Gly Val Asn Tyr Ala Thr Gly Asn Leu Pro Gly Cys Ser Phe Ser Ile 
                165                 170                 175     


Phe Leu Leu Ala Leu Leu Ser Cys Leu Thr Val Pro Ala Ser Ala Tyr 
            180                 185                 190         


Gln Val Arg Asn Ser Ser Gly Leu Tyr His Val Thr Asn Asp Cys Pro 
        195                 200                 205             


Asn Ser Ser Ile Val Tyr Glu Thr Ala Asp Ser Ile Leu His Ser Pro 
    210                 215                 220                 


Gly Cys Val Pro Cys Val Arg Glu Gly Asn Ala Ser Lys Cys Trp Val 
225                 230                 235                 240 


Ala Val Ala Pro Thr Val Ala Thr Arg Asp Gly Lys Leu Pro Ala Thr 
                245                 250                 255     


Gln Leu Arg Arg His Ile Asp Leu Leu Val Gly Ser Ala Thr Leu Cys 
            260                 265                 270         


Ser Ala Leu Tyr Val Gly Asp Leu Cys Gly Ser Val Phe Leu Val Ser 
        275                 280                 285             


Gln Leu Phe Thr Phe Ser Pro Arg Arg His Trp Thr Thr Gln Asp Cys 
    290                 295                 300                 


Asn Cys Ser Ile Tyr Pro Gly His Ile Thr Gly His Arg Met Ala Trp 
305                 310                 315                 320 


Asp Met Met Met Asn Trp Ser Pro Thr Thr Ala Leu Val Val Ser Gln 
                325                 330                 335     


Leu Leu Arg Val Pro Gln Ala Ile Leu Asp Met Ile Ala Gly Ala His 
            340                 345                 350         


Trp Gly Val Leu Ala Gly Ile Ala Tyr Phe Ser Met Val Gly Asn Trp 
        355                 360                 365             


Ala Lys Val Leu Val Val Leu Leu Leu Phe Ala Gly Val Asp Ala Glu 
    370                 375                 380                 


Thr His Thr Thr Gly Gly Ser Ala Ala Tyr Ala Thr Ser Gly Phe Val 
385                 390                 395                 400 


Gly Leu Phe Arg Gln Gly Ala Lys Gln Asn Ile Gln Leu Ile Asn Thr 
                405                 410                 415     


Asn Gly Ser Trp His Val Asn Arg Thr Ala Leu Asn Cys Asn Ala Ser 
            420                 425                 430         


Leu Asp Thr Gly Trp Val Ala Gly Leu Phe Tyr Tyr His Lys Phe Asn 
        435                 440                 445             


Ser Ser Gly Cys Pro Glu Arg Leu Ala Ser Cys Lys Pro Leu Ala Asn 
    450                 455                 460                 


Phe Asp Gln Gly Trp Gly Ser Ile Ser Tyr Thr Asn Gly Ser Gly Pro 
465                 470                 475                 480 


Glu His Arg Pro Tyr Cys Trp His Tyr Pro Pro Lys Pro Cys Gly Ile 
                485                 490                 495     


Val Pro Ala Gln Asn Val Cys Gly Pro Val Tyr Cys Phe Thr Pro Ser 
            500                 505                 510         


Pro Val Val Val Gly Thr Thr Asp Arg Leu Gly Ala Pro Thr Phe Asn 
        515                 520                 525             


Trp Gly Glu Asn Glu Ser Asp Val Phe Val Leu Asn Asn Thr Arg Pro 
    530                 535                 540                 


Pro Ser Gly Asn Trp Phe Gly Cys Thr Trp Met Asn Ser Ser Gly Phe 
545                 550                 555                 560 


Thr Lys Val Cys Gly Ala Pro Pro Cys Asn Ile Gly Gly Val Gly Asn 
                565                 570                 575     


Asn Thr Leu His Cys Pro Thr Asp Cys Phe Arg Lys His Pro Glu Ala 
            580                 585                 590         


Thr Tyr Ser Arg Cys Gly Ser Gly Pro Trp Val Thr Pro Arg Cys Leu 
        595                 600                 605             


Val His Tyr Pro Tyr Arg Leu Trp His Tyr Pro Cys Thr Leu Asn Tyr 
    610                 615                 620                 


Ser Leu Phe Lys Val Arg Met Tyr Val Gly Gly Ile Glu His Arg Leu 
625                 630                 635                 640 


Glu Val Ala Cys Asn Trp Thr Arg Gly Glu Arg Cys Asn Leu Asp Asp 
                645                 650                 655     


Arg Asp Arg Ser Glu Leu Ser Pro Leu Leu Leu Thr Thr Thr Gln Trp 
            660                 665                 670         


Gln Val Leu Pro Cys Ser Phe Thr Thr Leu Pro Ala Leu Thr Thr Gly 
        675                 680                 685             


Leu Ile His Leu His Gln Asn Val Val Asp Val Gln Tyr Leu Tyr Gly 
    690                 695                 700                 


Val Gly Ser Ser Ile Val Ser Trp Ala Ile Lys Trp Glu Tyr Val Ile 
705                 710                 715                 720 


Leu Leu Phe Leu Leu Leu Ala Asp Ala Arg Ile Cys Ser Cys Leu Trp 
                725                 730                 735     


Met Met Leu Leu Ile Ser Gln Ala Glu Ala 
            740                 745     


<210>  15
<211>  746
<212>  PRT
<213>  Hepatitis C virus

<400>  15

Met Ser Thr Asn Pro Lys Pro Gln Arg Lys Thr Lys Arg Asn Thr Asn 
1               5                   10                  15      


Arg Arg Pro Gln Asp Val Lys Phe Pro Gly Gly Gly Gln Ile Val Gly 
            20                  25                  30          


Gly Val Tyr Leu Leu Pro Arg Arg Gly Pro Arg Leu Gly Val Arg Ala 
        35                  40                  45              


Thr Arg Lys Thr Ser Glu Arg Ser Gln Pro Arg Gly Arg Arg Gln Pro 
    50                  55                  60                  


Ile Pro Lys Ala Arg Arg Pro Glu Gly Arg Thr Trp Ala Gln Pro Gly 
65                  70                  75                  80  


Tyr Pro Trp Pro Leu Tyr Gly Asn Glu Gly Cys Gly Trp Ala Gly Trp 
                85                  90                  95      


Leu Leu Ser Pro Arg Gly Ser Arg Pro Ser Trp Gly Pro Thr Asp Pro 
            100                 105                 110         


Arg Arg Arg Ser Arg Asn Leu Gly Lys Val Ile Asp Thr Leu Thr Cys 
        115                 120                 125             


Gly Phe Ala Asp Leu Met Gly Tyr Ile Pro Leu Val Gly Ala Pro Leu 
    130                 135                 140                 


Gly Gly Ala Ala Arg Ala Leu Ala His Gly Val Arg Val Leu Glu Asp 
145                 150                 155                 160 


Gly Val Asn Tyr Ala Thr Gly Asn Leu Pro Gly Cys Ser Phe Ser Ile 
                165                 170                 175     


Phe Leu Leu Ala Leu Leu Ser Cys Leu Thr Val Pro Ala Ser Ala Tyr 
            180                 185                 190         


Gln Val Arg Asn Ser Ser Gly Leu Tyr His Val Thr Asn Asp Cys Pro 
        195                 200                 205             


Asn Ser Ser Ile Val Tyr Glu Thr Ala Asp Thr Ile Leu His Ser Pro 
    210                 215                 220                 


Gly Cys Val Pro Cys Val Arg Glu Gly Asn Ala Ser Lys Cys Trp Val 
225                 230                 235                 240 


Ala Val Ala Pro Thr Val Ala Thr Arg Asp Gly Arg Leu Pro Thr Thr 
                245                 250                 255     


Gln Leu Arg Arg His Ile Asp Leu Leu Val Gly Ser Ala Thr Leu Cys 
            260                 265                 270         


Ser Ala Leu Tyr Val Gly Asp Leu Cys Gly Ser Val Phe Leu Val Gly 
        275                 280                 285             


Gln Leu Phe Thr Phe Ser Pro Arg His His Trp Thr Thr Gln Asp Cys 
    290                 295                 300                 


Asn Cys Ser Ile Tyr Pro Gly His Ile Thr Gly His Arg Met Ala Trp 
305                 310                 315                 320 


Asp Met Met Met Asn Trp Ser Pro Thr Thr Ala Leu Val Val Ala Gln 
                325                 330                 335     


Leu Leu Arg Val Pro Gln Ala Ile Leu Asp Met Ile Ala Gly Ala His 
            340                 345                 350         


Trp Gly Val Leu Ala Gly Ile Ala Tyr Phe Ser Met Val Gly Asn Trp 
        355                 360                 365             


Ala Lys Val Leu Val Val Leu Leu Leu Phe Ala Gly Val Asp Ala Thr 
    370                 375                 380                 


Thr His Thr Thr Gly Gly Ala Val Ala His Asn Thr Arg Met Phe Thr 
385                 390                 395                 400 


Ser Ile Phe Ser Leu Gly Pro Arg Gln Glu Ile Gln Leu Val Asn Thr 
                405                 410                 415     


Asn Gly Ser Trp His Ile Asn Arg Thr Ala Leu Asn Cys Asn Ala Ser 
            420                 425                 430         


Leu Glu Thr Gly Trp Ile Ala Gly Leu Leu Tyr Ala Asn Arg Phe Asn 
        435                 440                 445             


Ser Ser Gly Cys Pro Glu Arg Met Ala Ser Cys Lys Pro Leu Ala Asp 
    450                 455                 460                 


Phe Asp Gln Gly Trp Gly Pro Ile Ser Tyr Ala Asn Gly Ser Gly Pro 
465                 470                 475                 480 


Glu His Arg Pro Tyr Cys Trp His Tyr Pro Pro Lys Pro Cys Gly Ile 
                485                 490                 495     


Val Pro Ala Gln Asn Val Cys Gly Pro Val Tyr Cys Phe Thr Pro Ser 
            500                 505                 510         


Pro Val Val Val Gly Thr Thr Asp Arg Leu Gly Thr Pro Thr Tyr Asp 
        515                 520                 525             


Trp Gly Ser Asn Asp Thr Asp Val Phe Val Leu Asn Asn Thr Arg Pro 
    530                 535                 540                 


Pro Ala Gly Asn Trp Phe Gly Cys Thr Trp Met Asn Ser Ser Gly Tyr 
545                 550                 555                 560 


Thr Lys Val Cys Gly Ala Pro Pro Cys Val Ile Gly Gly Val Ser Asn 
                565                 570                 575     


Asn Thr Leu His Cys Pro Thr Asp Cys Phe Arg Lys His Pro Glu Ala 
            580                 585                 590         


Thr Tyr Ser Arg Cys Gly Ser Gly Pro Trp Ile Thr Pro Arg Cys Leu 
        595                 600                 605             


Val His Tyr Ala Tyr Arg Leu Trp His Tyr Pro Cys Thr Val Asn Tyr 
    610                 615                 620                 


Thr Leu Phe Lys Val Arg Met Tyr Val Gly Gly Val Glu His Arg Leu 
625                 630                 635                 640 


Glu Val Ala Cys Asn Trp Thr Arg Gly Glu Arg Cys Asn Leu Asp Asp 
                645                 650                 655     


Arg Asp Arg Ser Glu Leu Ser Pro Leu Leu Leu Ser Thr Thr Gln Trp 
            660                 665                 670         


Gln Val Leu Pro Cys Ser Phe Thr Thr Leu Pro Ala Leu Thr Thr Gly 
        675                 680                 685             


Leu Ile His Leu His Gln Asn Ile Val Asp Val Gln Tyr Leu Tyr Gly 
    690                 695                 700                 


Val Gly Ser Ser Ile Val Ser Trp Ala Val Lys Trp Glu Tyr Val Ile 
705                 710                 715                 720 


Leu Leu Phe Leu Leu Leu Ala Asp Ala Arg Ile Cys Ser Cys Leu Trp 
                725                 730                 735     


Met Met Leu Leu Ile Ser Gln Ala Glu Ala 
            740                 745     


<210>  16
<211>  746
<212>  PRT
<213>  Hepatitis C virus

<400>  16

Met Ser Thr Asn Pro Lys Pro Gln Arg Lys Thr Lys Arg Asn Thr Asn 
1               5                   10                  15      


Arg Arg Pro Gln Asp Val Lys Phe Pro Gly Gly Gly Gln Ile Val Gly 
            20                  25                  30          


Gly Val Tyr Leu Leu Pro Arg Arg Gly Pro Arg Leu Gly Val Arg Ala 
        35                  40                  45              


Thr Arg Lys Thr Ser Glu Arg Ser Gln Pro Arg Gly Arg Arg Gln Pro 
    50                  55                  60                  


Ile Pro Lys Ala Arg Gln Pro Glu Gly Arg Ala Trp Ala Gln Pro Gly 
65                  70                  75                  80  


Tyr Pro Trp Pro Leu Tyr Gly Asn Glu Gly Leu Gly Trp Ala Gly Trp 
                85                  90                  95      


Leu Leu Ser Pro Arg Gly Ser Arg Pro Ser Trp Gly Pro Thr Asp Pro 
            100                 105                 110         


Arg Arg Arg Ser Arg Asn Leu Gly Lys Val Ile Asp Thr Leu Thr Cys 
        115                 120                 125             


Gly Phe Ala Asp Leu Met Gly Tyr Ile Pro Leu Val Gly Ala Pro Leu 
    130                 135                 140                 


Gly Gly Ala Ala Arg Ala Leu Ala His Gly Val Arg Val Leu Glu Asp 
145                 150                 155                 160 


Gly Val Asn Tyr Ala Thr Gly Asn Leu Pro Gly Cys Ser Phe Ser Ile 
                165                 170                 175     


Phe Leu Leu Ala Leu Leu Ser Cys Leu Thr Ile Pro Ala Ser Ala Tyr 
            180                 185                 190         


Glu Val Arg Asn Val Ser Gly Val Tyr His Val Thr Asn Asp Cys Ser 
        195                 200                 205             


Asn Ala Ser Ile Val Tyr Glu Ala Ala Asp Met Ile Met His Thr Pro 
    210                 215                 220                 


Gly Cys Val Pro Cys Val Arg Glu Asn Asn Ser Ser Arg Cys Trp Val 
225                 230                 235                 240 


Ala Leu Thr Pro Thr Leu Ala Ala Arg Asn Ala Ser Val Pro Thr Thr 
                245                 250                 255     


Thr Ile Arg Arg His Val Asp Leu Leu Val Gly Ala Ala Ala Leu Cys 
            260                 265                 270         


Ser Ala Met Tyr Val Gly Asp Leu Cys Gly Ser Val Phe Leu Val Ala 
        275                 280                 285             


Gln Leu Phe Thr Phe Ser Pro Arg Arg His Glu Thr Val Gln Asp Cys 
    290                 295                 300                 


Asn Cys Ser Ile Tyr Pro Gly His Val Thr Gly His Arg Met Ala Trp 
305                 310                 315                 320 


Asp Met Met Met Asn Trp Ser Pro Thr Ala Ala Leu Val Val Ser Gln 
                325                 330                 335     


Leu Leu Arg Ile Pro Gln Ala Val Val Asp Met Val Ala Gly Ala His 
            340                 345                 350         


Trp Gly Val Leu Ala Gly Leu Ala Tyr Tyr Ser Met Val Gly Asn Trp 
        355                 360                 365             


Ala Lys Val Leu Ile Val Met Leu Leu Phe Ala Gly Val Asp Gly Gly 
    370                 375                 380                 


Thr Tyr Val Thr Gly Gly Thr Met Ala Lys Asn Thr Leu Gly Ile Thr 
385                 390                 395                 400 


Ser Leu Phe Ser Pro Gly Ser Ser Gln Lys Ile Gln Leu Val Asn Thr 
                405                 410                 415     


Asn Gly Ser Trp His Ile Asn Arg Thr Ala Leu Asn Cys Asn Asp Ser 
            420                 425                 430         


Leu Asn Thr Gly Phe Leu Ala Ala Leu Phe Tyr Val His Lys Phe Asn 
        435                 440                 445             


Ser Ser Gly Cys Pro Glu Arg Met Ala Ser Cys Ser Pro Ile Asp Ala 
    450                 455                 460                 


Phe Ala Gln Gly Trp Gly Pro Ile Thr Tyr Asn Glu Ser His Ser Ser 
465                 470                 475                 480 


Asp Gln Arg Pro Tyr Cys Trp His Tyr Ala Pro Arg Pro Cys Gly Ile 
                485                 490                 495     


Val Pro Ala Ala Gln Val Cys Gly Pro Val Tyr Cys Phe Thr Pro Ser 
            500                 505                 510         


Pro Val Val Val Gly Thr Thr Asp Arg Phe Gly Val Pro Thr Tyr Ser 
        515                 520                 525             


Trp Gly Glu Asn Glu Thr Asp Val Leu Leu Leu Asn Asn Thr Arg Pro 
    530                 535                 540                 


Pro Gln Gly Asn Trp Phe Gly Cys Thr Trp Met Asn Ser Thr Gly Phe 
545                 550                 555                 560 


Thr Lys Thr Cys Gly Gly Pro Pro Cys Asn Ile Gly Gly Ile Gly Asn 
                565                 570                 575     


Lys Thr Leu Thr Cys Pro Thr Asp Cys Phe Arg Lys His Pro Glu Ala 
            580                 585                 590         


Thr Tyr Thr Lys Cys Gly Ser Gly Pro Trp Leu Thr Pro Arg Cys Leu 
        595                 600                 605             


Val His Tyr Pro Tyr Arg Leu Trp His Tyr Pro Cys Thr Val Asn Phe 
    610                 615                 620                 


Thr Ile Phe Lys Val Arg Met Tyr Val Gly Gly Val Glu His Arg Leu 
625                 630                 635                 640 


Glu Ala Ala Cys Asn Trp Thr Arg Gly Glu Arg Cys Asn Leu Glu Asp 
                645                 650                 655     


Arg Asp Arg Ser Glu Leu Ser Pro Leu Leu Leu Ser Thr Thr Glu Trp 
            660                 665                 670         


Gln Val Leu Pro Cys Ser Phe Thr Thr Leu Pro Ala Leu Ser Thr Gly 
        675                 680                 685             


Leu Ile His Leu His Gln Asn Val Val Asp Val Gln Tyr Leu Tyr Gly 
    690                 695                 700                 


Ile Gly Ser Ala Val Val Ser Phe Ala Ile Lys Trp Glu Tyr Val Leu 
705                 710                 715                 720 


Leu Leu Phe Leu Leu Leu Ala Asp Ala Arg Val Cys Ala Cys Leu Trp 
                725                 730                 735     


Met Met Leu Leu Ile Ala Gln Ala Glu Ala 
            740                 745     


<210>  17
<211>  746
<212>  PRT
<213>  Hepatitis C virus

<400>  17

Met Ser Thr Asn Pro Lys Pro Gln Arg Lys Thr Lys Arg Asn Thr Asn 
1               5                   10                  15      


Arg Arg Pro Gln Asp Val Lys Phe Pro Gly Gly Gly Gln Ile Val Gly 
            20                  25                  30          


Gly Val Tyr Leu Leu Pro Arg Arg Gly Pro Arg Leu Gly Val Arg Ala 
        35                  40                  45              


Thr Arg Lys Thr Ser Glu Arg Ser Gln Pro Arg Gly Arg Arg Gln Pro 
    50                  55                  60                  


Ile Pro Lys Ala Arg Gln Pro Glu Gly Arg Ala Trp Ala Gln Pro Gly 
65                  70                  75                  80  


Tyr Pro Trp Pro Leu Tyr Gly Asn Glu Gly Met Gly Trp Ala Gly Trp 
                85                  90                  95      


Leu Leu Ser Pro Arg Gly Ser Arg Pro Ser Trp Gly Pro Thr Asp Pro 
            100                 105                 110         


Arg Arg Arg Ser Arg Asn Leu Gly Lys Val Ile Asp Thr Leu Thr Cys 
        115                 120                 125             


Gly Phe Ala Asp Leu Met Gly Tyr Ile Pro Leu Val Gly Ala Pro Leu 
    130                 135                 140                 


Gly Gly Val Ala Arg Ala Leu Ala His Gly Val Arg Val Val Glu Asp 
145                 150                 155                 160 


Gly Val Asn Tyr Ala Thr Gly Asn Leu Pro Gly Cys Ser Phe Ser Ile 
                165                 170                 175     


Phe Leu Leu Ala Leu Leu Ser Cys Leu Thr Ile Pro Ala Ser Ala Tyr 
            180                 185                 190         


Glu Val Arg Asn Val Ser Gly Ile Tyr His Val Thr Asn Asp Cys Ser 
        195                 200                 205             


Asn Ser Ser Ile Val Tyr Glu Ala Ala Asp Met Ile Met His Thr Pro 
    210                 215                 220                 


Gly Cys Val Pro Cys Val Arg Glu Gly Asn Ser Ser Arg Cys Trp Val 
225                 230                 235                 240 


Ala Leu Thr Pro Thr Leu Ala Ala Arg Asn Ala Ser Val Pro Thr Thr 
                245                 250                 255     


Ala Ile Arg Arg His Val Asp Leu Leu Val Gly Ala Ala Ala Phe Cys 
            260                 265                 270         


Ser Ala Met Tyr Val Gly Asp Leu Cys Gly Ser Val Phe Leu Val Ser 
        275                 280                 285             


Gln Leu Phe Thr Phe Ser Pro Arg Arg His Glu Thr Ile Gln Asp Cys 
    290                 295                 300                 


Asn Cys Ser Ile Tyr Pro Gly His Val Ser Gly His Arg Met Ala Trp 
305                 310                 315                 320 


Asp Met Met Met Asn Trp Ser Pro Thr Thr Ala Leu Val Val Ser Gln 
                325                 330                 335     


Leu Leu Arg Ile Pro Gln Ala Ile Val Asp Met Val Ala Gly Ala His 
            340                 345                 350         


Trp Gly Val Leu Ala Gly Leu Ala Tyr Tyr Ser Met Val Gly Asn Trp 
        355                 360                 365             


Ala Lys Val Leu Ile Val Met Leu Leu Phe Ala Gly Val Asp Gly Glu 
    370                 375                 380                 


Thr Arg Val Thr Gly Gly Gln Ile Ala Arg Asn Ala Tyr Ser Leu Thr 
385                 390                 395                 400 


Thr Leu Phe Ser Ser Gly Ser Ala Gln Asn Ile Gln Leu Ile Asn Thr 
                405                 410                 415     


Asn Gly Ser Trp His Ile Asn Arg Thr Ala Leu Asn Cys Asn Asp Ser 
            420                 425                 430         


Leu Asn Thr Gly Phe Leu Ala Ala Leu Phe Tyr Thr His Lys Phe Asn 
        435                 440                 445             


Ala Ser Gly Cys Pro Glu Arg Leu Ala Ser Cys Arg Pro Ile Asp Lys 
    450                 455                 460                 


Phe Asp Gln Gly Trp Gly Pro Ile Thr Tyr Ala Glu Gln Gly Gly Gln 
465                 470                 475                 480 


Asp Gln Arg Pro Tyr Cys Trp His Tyr Ala Pro Lys Pro Cys Gly Ile 
                485                 490                 495     


Val Ser Ala Ser Lys Val Cys Gly Pro Val Tyr Cys Phe Thr Pro Ser 
            500                 505                 510         


Pro Val Val Val Gly Thr Thr Asp Arg Phe Gly Val Pro Thr Tyr Ser 
        515                 520                 525             


Trp Gly Glu Asn Glu Thr Asp Val Leu Leu Leu Asn Asn Thr Arg Pro 
    530                 535                 540                 


Pro Gln Gly Asn Trp Phe Gly Cys Thr Trp Met Asn Gly Thr Gly Phe 
545                 550                 555                 560 


Thr Lys Thr Cys Gly Gly Pro Pro Cys Asn Ile Gly Gly Gly Gly Asn 
                565                 570                 575     


Asn Thr Leu Thr Cys Pro Thr Asp Cys Phe Arg Lys His Pro Ala Ala 
            580                 585                 590         


Thr Tyr Thr Lys Cys Gly Ser Gly Pro Trp Leu Thr Pro Arg Cys Leu 
        595                 600                 605             


Val Asp Tyr Pro Tyr Arg Leu Trp His Tyr Pro Cys Thr Ala Asn Phe 
    610                 615                 620                 


Thr Ile Phe Lys Val Arg Met Tyr Val Gly Gly Val Glu His Arg Leu 
625                 630                 635                 640 


Asp Ala Ala Cys Asn Trp Thr Arg Gly Glu Arg Cys Asn Leu Glu Asp 
                645                 650                 655     


Arg Asp Arg Leu Glu Leu Ser Pro Leu Leu Leu Ser Thr Thr Glu Trp 
            660                 665                 670         


Gln Val Leu Pro Cys Ser Phe Thr Thr Leu Pro Ala Leu Ser Thr Gly 
        675                 680                 685             


Leu Ile His Leu His Gln Asn Ile Val Asp Val Gln Tyr Leu Tyr Gly 
    690                 695                 700                 


Ile Gly Ser Ala Val Val Ser Phe Ala Ile Lys Trp Asp Tyr Ile Val 
705                 710                 715                 720 


Ile Leu Phe Leu Leu Leu Ala Asp Ala Arg Val Cys Ala Cys Leu Trp 
                725                 730                 735     


Met Met Leu Leu Ile Ala Gln Ala Glu Ala 
            740                 745     


<210>  18
<211>  747
<212>  PRT
<213>  Hepatitis C virus

<400>  18

Met Ser Thr Asn Pro Lys Pro Gln Arg Lys Thr Lys Arg Asn Thr Asn 
1               5                   10                  15      


Arg Arg Pro Gln Asp Val Lys Phe Pro Gly Gly Gly Gln Ile Val Gly 
            20                  25                  30          


Gly Val Tyr Leu Leu Pro Arg Arg Gly Pro Arg Leu Gly Val Arg Ala 
        35                  40                  45              


Ile Arg Lys Thr Ser Glu Arg Ser Gln Pro Arg Gly Arg Arg Gln Pro 
    50                  55                  60                  


Ile Pro Lys Ala Arg Arg Pro Glu Gly Arg Ala Trp Ala Gln Pro Gly 
65                  70                  75                  80  


Tyr Pro Trp Pro Leu Tyr Gly Asn Glu Gly Met Gly Trp Ala Gly Trp 
                85                  90                  95      


Leu Leu Ser Pro Arg Gly Ser Arg Pro Ser Trp Gly Pro Thr Asp Pro 
            100                 105                 110         


Arg Arg Arg Ser Arg Asn Leu Gly Lys Val Ile Asp Thr Leu Thr Cys 
        115                 120                 125             


Gly Leu Ala Asp Leu Met Gly Tyr Ile Pro Leu Val Gly Gly Pro Leu 
    130                 135                 140                 


Gly Gly Ala Ala Arg Ala Leu Ala His Gly Val Arg Val Leu Glu Asp 
145                 150                 155                 160 


Gly Val Asn Tyr Ala Thr Gly Asn Leu Pro Gly Cys Ser Phe Ser Ile 
                165                 170                 175     


Phe Leu Leu Ala Leu Leu Ser Cys Leu Thr Val Pro Ala Ser Ala His 
            180                 185                 190         


Glu Val Arg Asn Ala Ser Gly Val Tyr His Val Thr Asn Asp Cys Ser 
        195                 200                 205             


Asn Ser Ser Ile Val Phe Glu Ala Ala Asp Leu Ile Met His Thr Pro 
    210                 215                 220                 


Gly Cys Val Pro Cys Val Arg Glu Gly Asn Ser Ser Arg Cys Trp Val 
225                 230                 235                 240 


Ala Leu Thr Pro Thr Leu Ala Ala Arg Asn Ala Thr Ile Pro Thr Thr 
                245                 250                 255     


Thr Ile Arg His His Val Asp Leu Leu Val Gly Ala Ala Ala Leu Cys 
            260                 265                 270         


Ser Ala Met Tyr Val Gly Asp Leu Cys Gly Ser Val Phe Leu Val Ser 
        275                 280                 285             


Gln Leu Phe Thr Phe Ser Pro Arg Arg His Ala Thr Leu Gln Asp Cys 
    290                 295                 300                 


Asn Cys Ser Ile Tyr Pro Gly His Ala Ser Gly His Arg Met Ala Trp 
305                 310                 315                 320 


Asp Met Met Met Asn Trp Ser Pro Thr Thr Ala Leu Val Val Ser Gln 
                325                 330                 335     


Leu Leu Arg Ile Pro Gln Ala Val Ile Asp Met Val Ala Gly Ala His 
            340                 345                 350         


Trp Gly Val Leu Ala Gly Leu Ala Tyr Tyr Ser Met Ala Gly Asn Trp 
        355                 360                 365             


Ala Lys Val Leu Ile Val Met Leu Leu Phe Ala Gly Val Asp Gly His 
    370                 375                 380                 


Thr Leu Thr Thr Gly Gly His Ala Ala Arg Leu Thr Ser Gly Phe Ala 
385                 390                 395                 400 


Gly Leu Phe Thr Pro Gly Pro Ser Gln Arg Ile Gln Leu Ile Asn Thr 
                405                 410                 415     


Asn Gly Ser Trp His Ile Asn Arg Thr Ala Leu Asn Cys Asn Asp Ser 
            420                 425                 430         


Leu Gln Thr Gly Phe Leu Ala Ala Leu Phe Tyr Ala His Arg Phe Asn 
        435                 440                 445             


Ser Ser Gly Cys Pro Glu Arg Met Ala Ser Cys Arg Ser Ile Asp Lys 
    450                 455                 460                 


Phe Asp Gln Gly Trp Gly Pro Ile Thr Tyr Ala Glu Pro Thr Lys Asp 
465                 470                 475                 480 


Pro Asp Gln Arg Pro Tyr Cys Trp His Tyr Pro Pro Gln Gln Cys Gly 
                485                 490                 495     


Ile Val Pro Ala Ser Gln Val Cys Gly Pro Val Tyr Cys Phe Thr Pro 
            500                 505                 510         


Ser Pro Val Val Val Gly Thr Thr Asp Arg Leu Gly Asn Pro Thr Tyr 
        515                 520                 525             


Ser Trp Gly Glu Asn Asp Thr Asp Val Leu Leu Leu Asn Asn Thr Arg 
    530                 535                 540                 


Pro Pro Gln Gly Asn Trp Phe Gly Cys Thr Trp Met Asn Ser Thr Gly 
545                 550                 555                 560 


Phe Thr Lys Thr Cys Gly Ala Pro Pro Cys Asn Ile Gly Gly Val Gly 
                565                 570                 575     


Asn Asn Thr Leu Thr Cys Pro Thr Asp Cys Phe Arg Lys His Pro Glu 
            580                 585                 590         


Ala Thr Tyr Ser Lys Cys Gly Ser Gly Pro Trp Leu Thr Pro Arg Cys 
        595                 600                 605             


Met Val Asp Tyr Pro Tyr Arg Leu Trp His Tyr Pro Cys Thr Val Asn 
    610                 615                 620                 


Phe Ser Ile Phe Lys Val Arg Met Tyr Val Gly Gly Val Glu His Arg 
625                 630                 635                 640 


Leu Asn Ala Ala Cys Asn Trp Thr Arg Gly Glu Arg Cys Asn Leu Asp 
                645                 650                 655     


Asp Arg Asp Arg Ser Glu Leu Ser Pro Leu Leu Leu Ser Thr Thr Glu 
            660                 665                 670         


Trp Gln Val Leu Pro Cys Ser Phe Thr Thr Leu Pro Ala Leu Ser Thr 
        675                 680                 685             


Gly Leu Ile His Leu His Gln Asn Ile Val Asp Val Gln Tyr Leu Tyr 
    690                 695                 700                 


Gly Ile Gly Ser Ala Val Val Ser Phe Ala Ile Lys Trp Glu Tyr Val 
705                 710                 715                 720 


Val Leu Leu Phe Leu Leu Leu Ala Asp Ala Arg Val Cys Ala Cys Leu 
                725                 730                 735     


Trp Met Met Leu Leu Ile Ala Gln Ala Glu Ala 
            740                 745         


<210>  19
<211>  746
<212>  PRT
<213>  Hepatitis C virus

<400>  19

Met Ser Thr Asn Pro Lys Pro Gln Arg Lys Thr Lys Arg Asn Thr Asn 
1               5                   10                  15      


Arg Arg Pro Gln Asp Val Lys Phe Pro Gly Gly Gly Gln Ile Val Gly 
            20                  25                  30          


Gly Val Tyr Leu Leu Pro Arg Arg Gly Pro Arg Leu Gly Val Arg Ala 
        35                  40                  45              


Thr Arg Lys Thr Ser Glu Arg Ser Gln Pro Arg Gly Arg Arg Gln Pro 
    50                  55                  60                  


Ile Pro Lys Ala Arg His Pro Glu Gly Arg Thr Trp Ala Gln Pro Gly 
65                  70                  75                  80  


Tyr Pro Trp Pro Leu Tyr Gly Asn Glu Gly Leu Gly Trp Ala Gly Trp 
                85                  90                  95      


Leu Leu Ser Pro Arg Gly Ser Arg Pro Ser Trp Gly Pro Thr Asp Pro 
            100                 105                 110         


Arg Arg Arg Ser Arg Asn Leu Gly Lys Val Ile Asp Thr Leu Thr Cys 
        115                 120                 125             


Gly Phe Ala Asp Leu Met Gly Tyr Ile Pro Leu Val Gly Ala Pro Leu 
    130                 135                 140                 


Gly Gly Val Ala Arg Ala Leu Ala His Gly Val Arg Val Leu Glu Asp 
145                 150                 155                 160 


Gly Val Asn Tyr Ala Thr Gly Asn Leu Pro Gly Cys Ser Phe Ser Ile 
                165                 170                 175     


Phe Leu Leu Ala Leu Leu Ser Cys Leu Thr Ile Pro Ala Ser Ala Tyr 
            180                 185                 190         


Glu Val Arg Asn Val Ser Gly Val Tyr His Val Thr Asn Asp Cys Ser 
        195                 200                 205             


Asn Ser Ser Ile Val Tyr Glu Ala Ala Asp Val Ile Met His Thr Pro 
    210                 215                 220                 


Gly Cys Val Pro Cys Val Gln Asp Gly Asn Thr Ser Arg Cys Trp Val 
225                 230                 235                 240 


Ala Leu Thr Pro Thr Leu Ala Ala Arg Asn Ala Ser Val Pro Val Thr 
                245                 250                 255     


Ala Ile Arg Arg His Val Asp Leu Leu Val Gly Thr Ala Ala Phe Cys 
            260                 265                 270         


Ser Ala Met Tyr Val Gly Asp Leu Cys Gly Ser Val Phe Pro Val Ser 
        275                 280                 285             


Gln Leu Phe Thr Phe Ser Pro Arg Arg His Gln Thr Val Gln Asp Cys 
    290                 295                 300                 


Asn Cys Ser Ile Tyr Pro Gly His Ile Ser Gly His Arg Met Ala Trp 
305                 310                 315                 320 


Asp Met Met Met Asn Trp Ser Pro Thr Ala Ala Leu Val Val Ser Gln 
                325                 330                 335     


Leu Leu Arg Ile Pro Gln Ala Ile Val Asp Met Val Ala Gly Ala His 
            340                 345                 350         


Trp Gly Val Leu Ala Gly Leu Ala Tyr Tyr Ser Met Val Gly Asn Trp 
        355                 360                 365             


Ala Lys Val Met Ile Val Leu Leu Leu Phe Ala Gly Val Asp Gly Thr 
    370                 375                 380                 


Thr His Thr Thr Gly Gly Ala Ala Ala Arg Ala Thr Gln Gly Phe Thr 
385                 390                 395                 400 


Ser Phe Phe Ser Leu Gly Pro Ser Gln Lys Ile Gln Leu Ile Asn Thr 
                405                 410                 415     


Asn Gly Ser Trp His Ile Asn Arg Thr Ala Leu Asn Cys Asn Asp Ser 
            420                 425                 430         


Leu Gln Thr Gly Phe Leu Ala Ala Leu Phe Tyr Thr Tyr Arg Phe Asn 
        435                 440                 445             


Ala Ser Gly Cys Pro Glu Arg Met Ala Ser Cys Arg Pro Ile Asp Lys 
    450                 455                 460                 


Phe Asp Gln Gly Trp Gly Pro Ile Thr Tyr Ala Glu Pro Asp Ser Ser 
465                 470                 475                 480 


Asp Gln Arg Pro Tyr Cys Trp His Tyr Ala Pro Arg Pro Cys Gly Ile 
                485                 490                 495     


Val Pro Ala Ser Gln Val Cys Gly Pro Val Tyr Cys Phe Thr Pro Ser 
            500                 505                 510         


Pro Val Val Val Gly Thr Thr Asp Arg Phe Gly Val Pro Thr Tyr Thr 
        515                 520                 525             


Trp Gly Glu Asn Glu Thr Asp Val Leu Leu Leu Asn Asn Thr Arg Pro 
    530                 535                 540                 


Pro Leu Gly Asn Trp Phe Gly Cys Thr Trp Met Asn Ser Thr Gly Phe 
545                 550                 555                 560 


Thr Lys Thr Cys Gly Gly Pro Pro Cys Asn Ile Gly Gly Ala Gly Asn 
                565                 570                 575     


Thr Thr Leu Thr Cys Pro Thr Asp Cys Phe Arg Lys His Pro Glu Ala 
            580                 585                 590         


Thr Tyr Thr Lys Cys Gly Ser Gly Pro Trp Leu Thr Pro Arg Cys Leu 
        595                 600                 605             


Val Asp Tyr Pro Tyr Arg Leu Trp His Tyr Pro Cys Ala Val Asn Phe 
    610                 615                 620                 


Thr Ile Phe Lys Val Arg Met Tyr Val Gly Gly Val Glu His Arg Leu 
625                 630                 635                 640 


Asn Ala Ala Cys Asn Trp Thr Arg Gly Glu Arg Cys Asp Leu Glu Asp 
                645                 650                 655     


Arg Asp Arg Ser Glu Leu Ser Pro Leu Leu Leu Ser Thr Thr Glu Trp 
            660                 665                 670         


Gln Val Leu Pro Cys Ser Phe Thr Thr Leu Pro Ala Leu Ser Thr Gly 
        675                 680                 685             


Leu Ile His Leu His Gln Asn Ile Val Asp Val Gln Tyr Leu Tyr Gly 
    690                 695                 700                 


Ile Gly Ser Ala Val Ile Pro Phe Ala Ile Lys Trp Glu Tyr Val Leu 
705                 710                 715                 720 


Leu Leu Phe Leu Leu Leu Ala Asp Ala Arg Val Cys Ala Cys Leu Trp 
                725                 730                 735     


Met Met Leu Leu Ile Ala Gln Ala Glu Ala 
            740                 745     


<210>  20
<211>  746
<212>  PRT
<213>  Hepatitis C virus

<400>  20

Met Ser Thr Asn Pro Lys Pro Gln Arg Lys Thr Lys Arg Asn Thr Asn 
1               5                   10                  15      


Arg Arg Pro Gln Asp Val Lys Phe Pro Gly Gly Gly Gln Ile Val Gly 
            20                  25                  30          


Gly Val Tyr Leu Leu Pro Arg Arg Gly Pro Arg Leu Gly Val Arg Ala 
        35                  40                  45              


Thr Arg Lys Thr Ser Glu Arg Ser Gln Pro Arg Gly Arg Arg Gln Pro 
    50                  55                  60                  


Ile Pro Lys Ala Arg Arg Pro Glu Gly Arg Thr Trp Ala Gln Pro Gly 
65                  70                  75                  80  


Tyr Pro Trp Pro Leu Tyr Gly Asn Glu Gly Met Gly Trp Ala Gly Trp 
                85                  90                  95      


Leu Leu Ser Pro Arg Gly Ser Arg Pro Asn Trp Gly Pro Thr Asp Pro 
            100                 105                 110         


Arg Arg Arg Ser Arg Asn Leu Gly Lys Val Ile Asp Thr Leu Thr Cys 
        115                 120                 125             


Gly Phe Ala Asp Leu Met Gly Tyr Ile Pro Leu Val Gly Ala Pro Leu 
    130                 135                 140                 


Gly Gly Val Ala Arg Ala Leu Ala His Gly Val Arg Val Leu Glu Asp 
145                 150                 155                 160 


Gly Val Asn Tyr Ala Thr Gly Asn Leu Pro Gly Cys Ser Phe Ser Ile 
                165                 170                 175     


Phe Leu Leu Ala Leu Leu Ser Cys Leu Thr Thr Pro Ala Ser Ala Tyr 
            180                 185                 190         


Glu Val Arg Asn Val Ser Gly Ile Tyr His Val Thr Asn Asp Cys Ser 
        195                 200                 205             


Asn Ser Ser Ile Val Tyr Glu Ala Ala Asp Ile Ile Met His Thr Pro 
    210                 215                 220                 


Gly Cys Val Pro Cys Val Arg Glu Lys Asn Ile Ser Arg Cys Trp Val 
225                 230                 235                 240 


Ala Leu Thr Pro Thr Leu Ala Ala Arg Asn Ile Ser Val Pro Thr Ala 
                245                 250                 255     


Thr Ile Arg Arg His Val Asp Leu Leu Val Gly Thr Ala Ala Phe Cys 
            260                 265                 270         


Ser Ala Met Tyr Val Gly Asp Leu Cys Gly Ser Val Phe Leu Val Ser 
        275                 280                 285             


Gln Leu Phe Thr Phe Ser Pro Arg Trp His Glu Thr Val Gln Asp Cys 
    290                 295                 300                 


Asn Cys Ser Leu Tyr Pro Gly His Val Ser Gly His Arg Met Ala Trp 
305                 310                 315                 320 


Asp Met Met Met Asn Trp Ser Pro Thr Ala Ala Leu Val Val Ser Gln 
                325                 330                 335     


Leu Leu Arg Ile Pro Gln Ala Val Val Asp Met Val Ala Gly Ala His 
            340                 345                 350         


Trp Gly Val Leu Ala Gly Leu Ala Tyr Tyr Ser Met Ile Gly Asn Trp 
        355                 360                 365             


Ala Lys Val Leu Ile Val Met Leu Leu Phe Ala Gly Ala Asp Gly Thr 
    370                 375                 380                 


Thr His Val Thr Gly Gly Val Gln Ala His Gly Ala Tyr Gly Leu Ala 
385                 390                 395                 400 


Ser Leu Phe Asn Val Gly Pro His Gln Lys Ile Gln Leu Val Asn Thr 
                405                 410                 415     


Asn Gly Ser Trp His Ile Asn Arg Thr Ala Leu Asn Cys Asn Asp Thr 
            420                 425                 430         


Leu Gln Thr Gly Phe Leu Ala Ala Leu Phe Tyr Lys His Arg Phe Asn 
        435                 440                 445             


Ala Ser Gly Cys Pro Glu Arg Met Ala Ser Cys Arg Pro Ile Asp Lys 
    450                 455                 460                 


Phe Ala Gln Gly Trp Gly Pro Ile Thr Tyr Ala Glu Pro Asp Arg Leu 
465                 470                 475                 480 


Asp Gln Arg Pro Tyr Cys Trp His Tyr Pro Pro Arg Pro Cys Gly Ile 
                485                 490                 495     


Val Pro Ala Leu Glu Val Cys Gly Pro Val Tyr Cys Phe Thr Pro Ser 
            500                 505                 510         


Pro Val Val Val Gly Thr Thr Asp Arg Phe Gly Val Pro Thr Tyr Ser 
        515                 520                 525             


Trp Gly Glu Asn Glu Thr Asp Val Leu Leu Leu Asn Asn Thr Arg Pro 
    530                 535                 540                 


Pro Gln Gly Asn Trp Phe Gly Cys Thr Trp Met Asn Ser Thr Gly Tyr 
545                 550                 555                 560 


Thr Lys Thr Cys Gly Gly Pro Pro Cys Asn Ile Gly Gly Val Gly Asn 
                565                 570                 575     


Asn Thr Leu Thr Cys Pro Thr Asp Cys Phe Arg Lys His Pro Glu Ala 
            580                 585                 590         


Thr Tyr Thr Lys Cys Gly Ser Gly Pro Trp Leu Thr Pro Arg Cys Leu 
        595                 600                 605             


Val His Tyr Pro Tyr Arg Leu Trp His Tyr Pro Cys Thr Val Asn Phe 
    610                 615                 620                 


Thr Ile Phe Lys Val Arg Met Tyr Val Gly Gly Ile Glu His Arg Leu 
625                 630                 635                 640 


Asp Ala Ala Cys Asn Trp Thr Arg Gly Glu Arg Cys Asp Leu Glu Asp 
                645                 650                 655     


Arg Asp Arg Ser Glu Leu Ser Pro Leu Leu Leu Ser Thr Thr Glu Trp 
            660                 665                 670         


Gln Ile Leu Pro Cys Ser Phe Thr Thr Leu Pro Ala Leu Ser Thr Gly 
        675                 680                 685             


Leu Ile His Leu His Arg Asn Ile Val Asp Val Gln Tyr Leu Tyr Gly 
    690                 695                 700                 


Ile Gly Ser Ala Val Val Ser Phe Ala Ile Lys Trp Glu Tyr Val Leu 
705                 710                 715                 720 


Leu Leu Phe Leu Leu Leu Ala Asp Ala Arg Val Cys Ala Cys Leu Trp 
                725                 730                 735     


Met Met Leu Leu Ile Ala Gln Ala Glu Ala 
            740                 745     


<210>  21
<211>  746
<212>  PRT
<213>  Hepatitis C virus

<400>  21

Met Ser Thr Asn Pro Lys Pro Gln Arg Lys Thr Lys Arg Asn Thr Asn 
1               5                   10                  15      


Arg Arg Pro Gln Asp Val Lys Phe Pro Gly Gly Gly Gln Ile Val Gly 
            20                  25                  30          


Gly Val Tyr Leu Leu Pro Arg Arg Gly Pro Arg Leu Gly Val Arg Ala 
        35                  40                  45              


Thr Arg Lys Thr Ser Glu Arg Ser Gln Pro Arg Gly Arg Arg Gln Pro 
    50                  55                  60                  


Ile Pro Lys Ala Arg Arg Pro Glu Gly Arg Thr Trp Ala Gln Pro Gly 
65                  70                  75                  80  


Tyr Pro Trp Pro Leu Tyr Gly Asn Glu Gly Leu Gly Trp Ala Gly Trp 
                85                  90                  95      


Leu Leu Ser Pro Arg Gly Ser Arg Pro Ser Trp Gly Pro Asn Asp Pro 
            100                 105                 110         


Arg Arg Arg Ser Arg Asn Leu Gly Lys Val Ile Asp Thr Leu Thr Cys 
        115                 120                 125             


Gly Phe Ala Asp Leu Met Gly Tyr Ile Pro Leu Val Gly Ala Pro Leu 
    130                 135                 140                 


Gly Gly Ala Ala Arg Ala Leu Ala His Gly Val Arg Val Leu Glu Asp 
145                 150                 155                 160 


Gly Val Asn Tyr Ala Thr Gly Asn Leu Pro Gly Cys Ser Phe Ser Ile 
                165                 170                 175     


Phe Leu Leu Ala Leu Leu Ser Cys Leu Thr Ile Pro Ala Ser Ala Tyr 
            180                 185                 190         


Glu Val Arg Asn Val Ser Gly Ile Tyr His Val Thr Asn Asp Cys Ser 
        195                 200                 205             


Asn Ser Ser Ile Val Tyr Glu Ala Ala Asp Val Ile Met His Ala Pro 
    210                 215                 220                 


Gly Cys Val Pro Cys Val Arg Glu Asn Asn Ser Ser Arg Cys Trp Val 
225                 230                 235                 240 


Ala Leu Thr Pro Thr Leu Ala Ala Arg Asn Ala Ser Val Pro Thr Thr 
                245                 250                 255     


Thr Leu Arg Arg His Val Asp Leu Leu Val Gly Thr Ala Ala Phe Cys 
            260                 265                 270         


Ser Ala Met Tyr Val Gly Asp Leu Cys Gly Ser Val Phe Leu Ile Ser 
        275                 280                 285             


Gln Leu Phe Thr Phe Ser Pro Arg Arg His Glu Thr Val Gln Asp Cys 
    290                 295                 300                 


Asn Cys Ser Ile Tyr Pro Gly His Val Ser Gly His Arg Met Ala Trp 
305                 310                 315                 320 


Asp Met Met Met Asn Trp Ser Pro Thr Ala Ala Leu Val Val Ser Gln 
                325                 330                 335     


Leu Leu Arg Ile Pro Gln Ala Val Met Asp Met Val Ala Gly Ala His 
            340                 345                 350         


Trp Gly Val Leu Ala Gly Leu Ala Tyr Tyr Ser Met Val Gly Asn Trp 
        355                 360                 365             


Ala Lys Val Leu Ile Val Met Leu Leu Phe Ala Gly Val Asp Gly His 
    370                 375                 380                 


Thr Arg Val Thr Gly Gly Val Gln Gly His Val Thr Ser Thr Leu Thr 
385                 390                 395                 400 


Ser Leu Phe Arg Pro Gly Ala Ser Gln Lys Ile Gln Leu Val Asn Thr 
                405                 410                 415     


Asn Gly Ser Trp His Ile Asn Arg Thr Ala Leu Asn Cys Asn Asp Ser 
            420                 425                 430         


Leu Lys Thr Gly Phe Leu Ala Ala Leu Phe Tyr Thr His Lys Phe Asn 
        435                 440                 445             


Ala Ser Gly Cys Pro Glu Arg Met Ala Ser Cys Arg Ser Ile Asp Lys 
    450                 455                 460                 


Phe Asp Gln Gly Trp Gly Pro Ile Thr Tyr Ala Gln Pro Asp Asn Ser 
465                 470                 475                 480 


Asp Gln Arg Pro Tyr Cys Trp His Tyr Ala Pro Arg Gln Cys Gly Ile 
                485                 490                 495     


Val Pro Ala Ser Gln Val Cys Gly Pro Val Tyr Cys Phe Thr Pro Ser 
            500                 505                 510         


Pro Val Val Val Gly Thr Thr Asp Arg Phe Gly Ala Pro Thr Tyr Asn 
        515                 520                 525             


Trp Gly Asp Asn Glu Thr Asp Val Leu Leu Leu Asn Asn Thr Arg Pro 
    530                 535                 540                 


Pro His Gly Asn Trp Phe Gly Cys Thr Trp Met Asn Ser Thr Gly Phe 
545                 550                 555                 560 


Thr Lys Thr Cys Gly Gly Pro Pro Cys Asn Ile Arg Gly Val Gly Asn 
                565                 570                 575     


Asn Thr Leu Thr Cys Pro Thr Asp Cys Phe Arg Lys His Pro Asp Ala 
            580                 585                 590         


Thr Tyr Thr Lys Cys Gly Ser Gly Pro Trp Leu Thr Pro Arg Cys Leu 
        595                 600                 605             


Val Asp Tyr Pro Tyr Arg Leu Trp His Tyr Pro Cys Thr Val Asn Phe 
    610                 615                 620                 


Thr Ile Phe Lys Val Arg Met Tyr Val Gly Gly Val Glu His Arg Leu 
625                 630                 635                 640 


Asp Ala Ala Cys Asn Trp Thr Arg Gly Glu Arg Cys Asp Leu Glu Asp 
                645                 650                 655     


Arg Asp Arg Ala Glu Leu Ser Pro Leu Leu Leu Ser Thr Thr Glu Trp 
            660                 665                 670         


Gln Ile Leu Pro Cys Ser Tyr Thr Thr Leu Pro Ala Leu Ser Thr Gly 
        675                 680                 685             


Leu Ile His Leu His Gln Asn Ile Val Asp Ile Gln Tyr Leu Tyr Gly 
    690                 695                 700                 


Ile Gly Ser Ala Val Val Ser Ile Ala Ile Lys Trp Glu Tyr Val Val 
705                 710                 715                 720 


Leu Leu Phe Leu Leu Leu Ala Asp Ala Arg Val Cys Ala Cys Leu Trp 
                725                 730                 735     


Met Met Leu Leu Ile Ala Gln Ala Glu Ala 
            740                 745     


<210>  22
<211>  746
<212>  PRT
<213>  Hepatitis C virus

<400>  22

Met Ser Thr Asn Pro Lys Pro Gln Arg Lys Thr Lys Arg Asn Thr Asn 
1               5                   10                  15      


Arg Arg Pro Gln Asp Val Lys Phe Pro Gly Gly Gly Gln Ile Val Gly 
            20                  25                  30          


Gly Val Tyr Leu Leu Pro Arg Arg Gly Pro Arg Leu Gly Val Arg Ala 
        35                  40                  45              


Thr Arg Lys Thr Ser Glu Arg Ser Gln Pro Arg Gly Arg Arg Gln Pro 
    50                  55                  60                  


Ile Pro Lys Ala Arg Arg Pro Glu Gly Arg Thr Trp Ala Gln Pro Gly 
65                  70                  75                  80  


Tyr Pro Trp Pro Leu Tyr Gly Asp Glu Gly Met Gly Trp Ala Gly Trp 
                85                  90                  95      


Leu Leu Ser Pro Arg Gly Ser Arg Pro Asn Trp Gly Pro Thr Asp Pro 
            100                 105                 110         


Arg Arg Arg Ser Arg Asn Leu Gly Lys Val Ile Asp Thr Leu Thr Cys 
        115                 120                 125             


Gly Phe Ala Asp Leu Met Gly Tyr Ile Pro Leu Val Gly Ala Pro Leu 
    130                 135                 140                 


Gly Gly Val Ala Arg Ala Leu Ala His Gly Val Arg Val Leu Glu Asp 
145                 150                 155                 160 


Gly Val Asn Tyr Ala Thr Gly Asn Leu Pro Gly Cys Ser Phe Ser Ile 
                165                 170                 175     


Phe Leu Leu Ala Leu Leu Ser Cys Leu Thr Thr Pro Ala Ser Ala Tyr 
            180                 185                 190         


Glu Val Arg Asn Val Ser Gly Ile Tyr His Val Thr Asn Asp Cys Ser 
        195                 200                 205             


Asn Ser Ser Ile Val Tyr Glu Ala Ala Asp Ile Ile Met His Thr Pro 
    210                 215                 220                 


Gly Cys Val Pro Cys Val Arg Glu Lys Asn Thr Ser Arg Cys Trp Val 
225                 230                 235                 240 


Ala Leu Thr Pro Thr Leu Ala Ala Arg Asn Ile Ser Val Pro Thr Thr 
                245                 250                 255     


Thr Ile Arg Arg His Val Asp Leu Leu Val Gly Thr Ala Ala Phe Cys 
            260                 265                 270         


Ser Ala Met Tyr Val Gly Asp Leu Cys Gly Ser Val Phe Leu Val Ser 
        275                 280                 285             


Gln Leu Phe Thr Phe Ser Pro Arg Arg His Glu Thr Val Gln Asp Cys 
    290                 295                 300                 


Asn Cys Ser Leu Tyr Pro Gly His Val Ser Gly His Arg Met Ala Trp 
305                 310                 315                 320 


Asp Met Met Met Asn Trp Ser Pro Thr Ala Ala Leu Val Val Ser Gln 
                325                 330                 335     


Leu Leu Arg Ile Pro Gln Ala Ile Val Asp Met Val Ala Gly Ala His 
            340                 345                 350         


Trp Gly Val Leu Ala Gly Leu Ala Tyr Tyr Ser Met Val Gly Asn Trp 
        355                 360                 365             


Ala Lys Val Leu Ile Val Met Leu Leu Phe Ala Gly Ala Asp Gly Thr 
    370                 375                 380                 


Thr His Val Thr Gly Gly Val Gln Ala His Gly Ala Tyr Gly Leu Ala 
385                 390                 395                 400 


Ser Leu Phe Asn Val Gly Pro His Gln Lys Ile Gln Leu Val Asn Thr 
                405                 410                 415     


Asn Gly Ser Trp His Ile Asn Arg Thr Ala Leu Asn Cys Asn Asp Thr 
            420                 425                 430         


Leu Gln Thr Gly Phe Leu Ala Ala Leu Phe Tyr Lys His Arg Phe Asn 
        435                 440                 445             


Ala Ser Gly Cys Pro Glu Arg Met Ala Ser Cys Arg Pro Ile Asp Lys 
    450                 455                 460                 


Phe Ala Gln Gly Trp Gly Pro Ile Thr Tyr Ala Glu Pro Asp Arg Leu 
465                 470                 475                 480 


Asp Gln Arg Pro Tyr Cys Trp His Tyr Pro Pro Arg Pro Cys Gly Ile 
                485                 490                 495     


Val Pro Ala Leu Glu Val Cys Gly Pro Val Tyr Cys Phe Thr Pro Ser 
            500                 505                 510         


Pro Val Val Val Gly Thr Thr Asp Arg Phe Gly Val Pro Thr Tyr Ser 
        515                 520                 525             


Trp Gly Glu Asn Glu Thr Asp Val Leu Leu Leu Asn Asn Thr Arg Pro 
    530                 535                 540                 


Pro Gln Gly Asn Trp Phe Gly Cys Thr Trp Met Asn Asn Thr Gly Phe 
545                 550                 555                 560 


Thr Lys Thr Cys Gly Gly Pro Pro Cys Asn Ile Gly Gly Val Gly Asn 
                565                 570                 575     


Asn Thr Leu Thr Cys Pro Thr Asp Cys Phe Arg Lys His Pro Glu Ala 
            580                 585                 590         


Thr Tyr Thr Lys Cys Gly Ser Gly Pro Trp Leu Thr Pro Arg Cys Leu 
        595                 600                 605             


Val Asp Tyr Pro Tyr Arg Leu Trp His Tyr Pro Cys Thr Val Asn Phe 
    610                 615                 620                 


Thr Val Phe Lys Val Arg Met Tyr Val Gly Gly Ile Glu His Arg Leu 
625                 630                 635                 640 


Asp Ala Ala Cys Asn Trp Thr Arg Gly Glu Arg Cys Asp Leu Glu Asp 
                645                 650                 655     


Arg Asp Arg Ser Glu Leu Ser Pro Leu Leu Leu Ser Thr Thr Glu Trp 
            660                 665                 670         


Gln Ile Leu Pro Cys Ser Phe Thr Thr Leu Pro Ala Leu Ser Thr Gly 
        675                 680                 685             


Leu Ile His Leu His Arg Asn Ile Val Asp Val Gln Tyr Leu Tyr Gly 
    690                 695                 700                 


Ile Gly Ser Ala Val Val Ser Phe Ala Ile Lys Trp Glu Tyr Ile Leu 
705                 710                 715                 720 


Leu Leu Phe Leu Leu Leu Ala Asp Ala Arg Val Cys Ala Cys Leu Trp 
                725                 730                 735     


Met Met Leu Leu Ile Ala Gln Ala Glu Ala 
            740                 745     


<210>  23
<211>  746
<212>  PRT
<213>  Hepatitis C virus

<400>  23

Met Ser Thr Asn Pro Lys Pro Gln Arg Lys Thr Lys Arg Asn Thr Asn 
1               5                   10                  15      


Arg Arg Pro Gln Asp Val Lys Phe Pro Gly Gly Gly Gln Ile Val Gly 
            20                  25                  30          


Gly Val Tyr Leu Leu Pro Arg Arg Gly Pro Arg Leu Gly Val Arg Ala 
        35                  40                  45              


Thr Arg Lys Thr Ser Glu Arg Ser Gln Pro Arg Gly Arg Arg Gln Pro 
    50                  55                  60                  


Ile Pro Lys Ala Arg Gln Pro Glu Gly Arg Ala Trp Ala Gln Pro Gly 
65                  70                  75                  80  


Tyr Pro Trp Pro Leu Tyr Gly Asn Glu Gly Leu Gly Trp Ala Gly Trp 
                85                  90                  95      


Leu Leu Ser Pro Arg Gly Ser Arg Pro Ser Trp Gly Pro Thr Asp Pro 
            100                 105                 110         


Arg Arg Arg Ser Arg Asn Leu Gly Lys Val Ile Asp Thr Leu Thr Cys 
        115                 120                 125             


Gly Phe Ala Asp Leu Met Gly Tyr Ile Pro Leu Val Gly Ala Pro Leu 
    130                 135                 140                 


Gly Gly Ala Ala Arg Ala Leu Ala His Gly Val Arg Val Leu Glu Asp 
145                 150                 155                 160 


Gly Val Asn Tyr Ala Thr Gly Asn Leu Pro Gly Cys Ser Phe Ser Ile 
                165                 170                 175     


Phe Leu Leu Ala Leu Leu Ser Cys Leu Thr Ile Pro Ala Ser Ala Tyr 
            180                 185                 190         


Glu Val Arg Asn Val Ser Gly Val Tyr His Val Thr Asn Asp Cys Ser 
        195                 200                 205             


Asn Ser Ser Ile Val Tyr Glu Ala Ala Asp Met Ile Met His Thr Pro 
    210                 215                 220                 


Gly Cys Val Pro Cys Val Arg Glu Asp Asn Ser Ser Arg Cys Trp Val 
225                 230                 235                 240 


Ala Leu Thr Pro Thr Leu Ala Ala Arg Asn Ser Ser Val Pro Thr Thr 
                245                 250                 255     


Thr Ile Arg Arg His Val Asp Leu Leu Val Gly Ala Ala Ala Phe Cys 
            260                 265                 270         


Ser Ala Met Tyr Val Gly Asp Leu Cys Gly Ser Val Phe Leu Ile Ser 
        275                 280                 285             


Gln Leu Phe Thr Phe Ser Pro Arg Arg Tyr Glu Thr Val Gln Asp Cys 
    290                 295                 300                 


Asn Cys Ser Leu Tyr Pro Gly His Val Ser Gly His Arg Met Ala Trp 
305                 310                 315                 320 


Asp Met Met Met Asn Trp Ser Pro Thr Thr Ala Leu Val Val Ser Gln 
                325                 330                 335     


Leu Leu Arg Ile Pro Gln Ala Val Val Asp Met Val Ala Gly Ala His 
            340                 345                 350         


Trp Gly Val Leu Ala Gly Leu Ala Tyr Tyr Ser Met Val Gly Asn Trp 
        355                 360                 365             


Ala Lys Val Leu Ile Val Met Leu Leu Phe Ala Gly Val Asp Gly Asn 
    370                 375                 380                 


Thr Arg Val Ser Gly Gly Glu Ala Ala Lys Asn Thr Met Gly Phe Ala 
385                 390                 395                 400 


Ser Leu Phe Val Ser Gly Pro Ser Gln Lys Ile Gln Leu Ile Asn Thr 
                405                 410                 415     


Asn Gly Ser Trp His Ile Asn Arg Thr Ala Leu Asn Cys Asp Asp Ser 
            420                 425                 430         


Leu His Thr Gly Phe Leu Ala Ala Leu Phe Tyr Ala His Lys Phe Asn 
        435                 440                 445             


Ser Ser Gly Cys Ser Gly Arg Met Ala Ser Cys Arg Pro Ile Asp Glu 
    450                 455                 460                 


Phe Ala Gln Gly Trp Gly Pro Ile Thr His Gly Val Pro Asp Asn Leu 
465                 470                 475                 480 


Asp Gln Arg Pro Tyr Cys Trp His Tyr Ala Pro Arg Pro Cys Gly Ile 
                485                 490                 495     


Val Pro Ala Ser Gln Val Cys Gly Pro Val Tyr Cys Phe Thr Pro Ser 
            500                 505                 510         


Pro Val Val Val Gly Thr Thr Asp Arg Phe Gly Ala Pro Thr Tyr Ser 
        515                 520                 525             


Trp Gly Glu Asn Glu Thr Asp Val Leu Leu Leu Asn Asn Thr Arg Pro 
    530                 535                 540                 


Pro Gln Gly Asn Trp Phe Gly Cys Thr Trp Met Asn Ser Thr Gly Phe 
545                 550                 555                 560 


Thr Lys Thr Cys Gly Gly Pro Pro Cys Asn Ile Gly Gly Val Gly Asn 
                565                 570                 575     


Asn Thr Leu Thr Cys Pro Thr Asp Cys Phe Arg Lys His Pro Glu Ala 
            580                 585                 590         


Thr Tyr Thr Lys Cys Gly Ser Gly Pro Trp Leu Thr Pro Arg Cys Met 
        595                 600                 605             


Val Asp Tyr Pro Tyr Arg Leu Trp His Tyr Pro Cys Thr Val Asn Phe 
    610                 615                 620                 


Thr Ile Phe Lys Val Arg Met Tyr Val Gly Gly Val Glu His Arg Leu 
625                 630                 635                 640 


Asp Ala Ala Cys Asn Trp Thr Arg Gly Glu Arg Cys Asn Val Glu Asp 
                645                 650                 655     


Arg Asp Arg Ser Glu Leu Ser Pro Leu Leu Leu Ser Thr Thr Glu Trp 
            660                 665                 670         


Gln Ile Leu Pro Cys Ser Phe Thr Thr Leu Pro Ala Leu Ser Thr Gly 
        675                 680                 685             


Leu Ile His Leu His Gln Asn Ile Val Asp Val Gln Tyr Leu Tyr Gly 
    690                 695                 700                 


Val Gly Ser Val Val Val Ser Val Val Ile Arg Trp Glu Tyr Val Val 
705                 710                 715                 720 


Leu Leu Phe Leu Leu Leu Ala Asp Ala Arg Val Cys Ala Cys Leu Trp 
                725                 730                 735     


Met Met Leu Leu Ile Ala Gln Ala Glu Ala 
            740                 745     


<210>  24
<211>  746
<212>  PRT
<213>  Hepatitis C virus

<400>  24

Met Ser Thr Asn Pro Lys Pro Gln Arg Lys Thr Lys Arg Asn Thr Asn 
1               5                   10                  15      


Arg Arg Pro Gln Asp Val Lys Phe Pro Gly Gly Gly Gln Ile Val Gly 
            20                  25                  30          


Gly Val Tyr Leu Leu Pro Arg Arg Gly Pro Arg Leu Gly Val Arg Ala 
        35                  40                  45              


Thr Arg Lys Thr Ser Glu Arg Ser Gln Pro Arg Gly Arg Arg Gln Pro 
    50                  55                  60                  


Ile Pro Lys Ala Arg Gln Pro Glu Gly Arg Ala Trp Ala Gln Pro Gly 
65                  70                  75                  80  


Tyr Pro Trp Pro Leu Tyr Gly Asn Glu Gly Met Gly Trp Ala Gly Trp 
                85                  90                  95      


Leu Leu Ser Pro Arg Gly Ser Arg Pro Ser Trp Gly Pro Thr Asp Pro 
            100                 105                 110         


Arg Arg Arg Ser Arg Asn Leu Gly Lys Val Ile Asp Thr Leu Thr Cys 
        115                 120                 125             


Gly Phe Ala Asp Leu Met Gly Tyr Ile Pro Leu Val Gly Ala Pro Leu 
    130                 135                 140                 


Gly Gly Ala Ala Arg Ala Leu Ala His Gly Val Arg Val Leu Glu Asp 
145                 150                 155                 160 


Gly Val Asn Tyr Ala Thr Gly Asn Leu Pro Gly Cys Ser Phe Ser Ile 
                165                 170                 175     


Phe Leu Leu Ala Leu Leu Ser Cys Leu Thr Ile Pro Ala Ser Ala Tyr 
            180                 185                 190         


Glu Val Arg Asn Val Ser Gly Met Tyr His Val Thr Asn Asp Cys Ser 
        195                 200                 205             


Asn Ser Ser Ile Val Tyr Glu Ala Ala Asp Met Ile Leu His Ala Pro 
    210                 215                 220                 


Gly Cys Val Pro Cys Val Arg Glu Asn Asn Ser Ser Arg Cys Trp Val 
225                 230                 235                 240 


Ala Leu Thr Pro Thr Leu Ala Ala Arg Asn Ala Ser Val Pro Thr Thr 
                245                 250                 255     


Ala Ile Arg Arg His Val Asp Leu Leu Val Gly Ala Ala Ala Phe Cys 
            260                 265                 270         


Ser Ala Met Tyr Val Gly Asp Leu Cys Gly Ser Val Leu Leu Val Ser 
        275                 280                 285             


Gln Ile Phe Thr Phe Ser Pro Arg Arg His Glu Thr Met Gln Asp Cys 
    290                 295                 300                 


Asn Cys Ser Ile Tyr Pro Gly His Ile Thr Gly His Arg Met Ala Trp 
305                 310                 315                 320 


Asp Met Met Met Asn Trp Ser Pro Thr Thr Ala Leu Val Val Ser Gln 
                325                 330                 335     


Leu Leu Arg Ile Pro Gln Ala Ile Val Asp Met Val Ala Gly Ala His 
            340                 345                 350         


Trp Gly Val Leu Ala Gly Leu Ala Tyr Tyr Ser Met Val Gly Asn Trp 
        355                 360                 365             


Ala Lys Val Leu Ile Val Met Leu Leu Phe Ala Gly Val Asp Gly Gly 
    370                 375                 380                 


Thr Tyr Val Thr Gly Gly Glu Ala Gly Arg Arg Thr Ser Gly Phe Ala 
385                 390                 395                 400 


Ser Ile Phe Thr Pro Gly Ala Ser Gln Asn Ile Gln Leu Ile Asn Thr 
                405                 410                 415     


Asn Gly Ser Trp His Ile Asn Arg Thr Ala Leu Asn Cys Asn Asp Ser 
            420                 425                 430         


Leu His Thr Gly Phe Ile Ala Ala Leu Phe Tyr His His Lys Phe Asn 
        435                 440                 445             


Ala Ser Gly Cys Pro Glu Arg Met Ala Ser Cys Arg Pro Ile Gly Glu 
    450                 455                 460                 


Phe Ala Gln Gly Trp Gly Pro Ile Ser Tyr Thr Glu Pro Pro Ser Ser 
465                 470                 475                 480 


Asp Gln Arg Pro Tyr Cys Trp His Tyr Pro Pro Arg Pro Cys Gly Ile 
                485                 490                 495     


Val Pro Ala Ser Gln Val Cys Gly Pro Val Tyr Cys Phe Thr Pro Ser 
            500                 505                 510         


Pro Val Val Val Gly Thr Thr Asp Arg Leu Gly Ala Pro Thr Tyr Asn 
        515                 520                 525             


Trp Gly Asp Asn Asp Thr Asp Val Leu Leu Leu Asn Asn Thr Arg Pro 
    530                 535                 540                 


Pro Gln Gly Asn Trp Phe Gly Cys Thr Trp Met Asn Gly Thr Gly Phe 
545                 550                 555                 560 


Thr Lys Thr Cys Gly Gly Pro Pro Cys Asn Ile Gly Gly Val Gly Asn 
                565                 570                 575     


Asn Thr Leu Thr Cys Pro Thr Asp Cys Phe Arg Lys His Pro Glu Ala 
            580                 585                 590         


Thr Tyr Thr Lys Cys Gly Ser Gly Pro Trp Leu Thr Pro Arg Cys Ile 
        595                 600                 605             


Val Asp Tyr Pro Tyr Arg Leu Trp His Tyr Pro Cys Thr Val Asn Phe 
    610                 615                 620                 


Thr Ile Thr Lys Ile Arg Met Tyr Val Gly Gly Val Glu His Arg Leu 
625                 630                 635                 640 


Thr Ala Ala Cys Asn Trp Thr Arg Gly Glu Arg Cys Asp Leu Glu Asp 
                645                 650                 655     


Arg Asp Arg Ser Glu Leu Ser Pro Leu Leu Leu Ser Thr Thr Glu Trp 
            660                 665                 670         


Gln Ile Met Pro Cys Ser Phe Thr Thr Leu Pro Ala Leu Ser Thr Gly 
        675                 680                 685             


Leu Ile His Leu His Gln Asn Ile Val Asp Ile Gln Tyr Leu Tyr Gly 
    690                 695                 700                 


Ile Gly Ser Ala Ala Val Ser Phe Ala Ile Arg Trp Glu Tyr Val Leu 
705                 710                 715                 720 


Leu Leu Phe Leu Leu Leu Ala Asp Ala Arg Val Cys Ala Cys Leu Trp 
                725                 730                 735     


Met Met Leu Leu Ile Ala Gln Ala Glu Ala 
            740                 745     


<210>  25
<211>  746
<212>  PRT
<213>  Hepatitis C virus

<400>  25

Met Ser Thr Asn Pro Lys Pro Gln Arg Lys Thr Lys Arg Asn Thr Asn 
1               5                   10                  15      


Arg Arg Pro Gln Asp Val Lys Phe Pro Gly Gly Gly Gln Ile Val Gly 
            20                  25                  30          


Gly Val Tyr Leu Leu Pro Arg Arg Gly Pro Arg Leu Gly Val Arg Ala 
        35                  40                  45              


Thr Arg Lys Thr Ser Glu Arg Ser Gln Pro Arg Gly Arg Arg Gln Pro 
    50                  55                  60                  


Ile Pro Lys Ala Arg Gln Pro Glu Gly Arg Ala Trp Ala Gln Pro Gly 
65                  70                  75                  80  


Tyr Pro Trp Pro Leu Tyr Gly Asn Glu Gly Met Gly Trp Ala Gly Trp 
                85                  90                  95      


Leu Leu Ser Pro Arg Gly Ser Arg Pro Ser Trp Gly Pro Thr Asp Pro 
            100                 105                 110         


Arg Arg Arg Ser Arg Asn Leu Gly Lys Val Ile Asp Thr Leu Thr Cys 
        115                 120                 125             


Gly Phe Ala Asp Leu Met Gly Tyr Ile Pro Leu Val Gly Ala Pro Leu 
    130                 135                 140                 


Gly Gly Ala Ala Arg Ala Leu Ala His Gly Val Arg Val Leu Glu Asp 
145                 150                 155                 160 


Gly Val Asn Tyr Ala Thr Gly Asn Leu Pro Gly Cys Ser Phe Ser Ile 
                165                 170                 175     


Phe Leu Leu Ala Leu Leu Ser Cys Leu Thr Ile Pro Ala Ser Ala Tyr 
            180                 185                 190         


Glu Val Arg Asn Val Ser Gly Met Tyr His Val Thr Asn Asp Cys Ser 
        195                 200                 205             


Asn Ser Ser Ile Val Tyr Glu Ala Ala Asp Met Ile Leu His Ala Pro 
    210                 215                 220                 


Gly Cys Val Pro Cys Val Arg Glu Asn Asn Ser Ser Arg Cys Trp Val 
225                 230                 235                 240 


Ala Leu Thr Pro Thr Leu Ala Ala Arg Asn Ala Ser Val Pro Thr Thr 
                245                 250                 255     


Ala Ile Arg Arg His Val Asp Leu Leu Val Gly Ala Ala Ala Phe Cys 
            260                 265                 270         


Ser Ala Met Tyr Val Gly Asp Leu Cys Gly Ser Val Leu Leu Val Ser 
        275                 280                 285             


Gln Ile Phe Thr Phe Ser Pro Arg Arg His Glu Thr Met Gln Asp Cys 
    290                 295                 300                 


Asn Cys Ser Ile Tyr Pro Gly His Ile Thr Gly His Arg Met Ala Trp 
305                 310                 315                 320 


Asp Met Met Met Asn Trp Ser Pro Thr Thr Ala Leu Val Val Ser Gln 
                325                 330                 335     


Leu Leu Arg Ile Pro Gln Ala Ile Val Asp Met Val Ala Gly Ala His 
            340                 345                 350         


Trp Gly Val Leu Ala Gly Leu Ala Tyr Tyr Ser Met Val Gly Asn Trp 
        355                 360                 365             


Ala Lys Val Leu Ile Val Met Leu Leu Phe Ala Gly Val Asp Gly Gly 
    370                 375                 380                 


Thr Tyr Val Thr Gly Gly Glu Ala Gly Arg Arg Thr Ser Gly Phe Ala 
385                 390                 395                 400 


Ser Ile Phe Thr Pro Gly Ala Ser Gln Asn Ile Gln Leu Ile Asn Thr 
                405                 410                 415     


Asn Gly Ser Trp His Ile Asn Arg Thr Ala Leu Asn Cys Asn Asp Ser 
            420                 425                 430         


Leu His Thr Gly Phe Ile Ala Ala Leu Phe Tyr His His Lys Phe Asn 
        435                 440                 445             


Ala Ser Gly Cys Pro Glu Arg Met Ala Ser Cys Arg Pro Ile Gly Glu 
    450                 455                 460                 


Phe Ala Gln Gly Trp Gly Pro Ile Ser Tyr Thr Glu Pro Pro Ser Ser 
465                 470                 475                 480 


Asp Gln Arg Pro Tyr Cys Trp His Tyr Pro Pro Arg Pro Cys Gly Ile 
                485                 490                 495     


Val Pro Ala Ser Gln Val Cys Gly Pro Val Tyr Cys Phe Thr Pro Ser 
            500                 505                 510         


Pro Val Val Val Gly Thr Thr Asp Arg Leu Gly Ala Pro Thr Tyr Asn 
        515                 520                 525             


Trp Gly Asp Asn Asp Thr Asp Val Leu Leu Leu Asn Asn Thr Arg Pro 
    530                 535                 540                 


Pro Gln Gly Asn Trp Phe Gly Cys Thr Trp Met Asn Gly Thr Gly Phe 
545                 550                 555                 560 


Thr Lys Thr Cys Gly Gly Pro Pro Cys Asn Ile Gly Gly Val Gly Asn 
                565                 570                 575     


Asn Thr Leu Thr Cys Pro Thr Asp Cys Phe Arg Lys His Pro Glu Ala 
            580                 585                 590         


Thr Tyr Thr Lys Cys Gly Ser Gly Pro Trp Leu Thr Pro Arg Cys Ile 
        595                 600                 605             


Val Asp Tyr Pro Tyr Arg Leu Trp His Tyr Pro Cys Thr Val Asn Phe 
    610                 615                 620                 


Thr Ile Thr Lys Ile Arg Met Tyr Val Gly Gly Val Glu His Arg Leu 
625                 630                 635                 640 


Thr Ala Ala Cys Asn Trp Thr Arg Gly Glu Arg Cys Asp Leu Glu Asp 
                645                 650                 655     


Arg Asp Arg Ser Glu Leu Ser Pro Leu Leu Leu Ser Thr Thr Glu Trp 
            660                 665                 670         


Gln Ile Met Pro Cys Ser Phe Thr Thr Leu Pro Ala Leu Ser Thr Gly 
        675                 680                 685             


Leu Ile His Leu His Gln Asn Ile Val Asp Ile Gln Tyr Leu Tyr Gly 
    690                 695                 700                 


Ile Gly Ser Ala Ala Val Ser Phe Ala Ile Arg Trp Glu Tyr Val Leu 
705                 710                 715                 720 


Leu Leu Phe Leu Leu Leu Ala Asp Ala Arg Val Cys Ala Cys Leu Trp 
                725                 730                 735     


Met Met Leu Leu Ile Ala Gln Ala Glu Ala 
            740                 745     


<210>  26
<211>  746
<212>  PRT
<213>  Hepatitis C virus

<400>  26

Met Ser Thr Asn Pro Lys Pro Gln Arg Lys Thr Lys Arg Asn Thr Asn 
1               5                   10                  15      


Arg Arg Pro Gln Asp Val Lys Phe Pro Gly Gly Gly Gln Ile Val Gly 
            20                  25                  30          


Gly Val Tyr Leu Leu Pro Arg Arg Gly Pro Arg Leu Gly Val Arg Ala 
        35                  40                  45              


Thr Arg Lys Thr Ser Glu Arg Ser Gln Pro Arg Gly Arg Arg Gln Pro 
    50                  55                  60                  


Ile Pro Lys Ala Arg Arg Pro Glu Gly Arg Ala Trp Ala Gln Pro Gly 
65                  70                  75                  80  


Tyr Pro Trp Pro Leu Tyr Gly Asn Glu Gly Leu Gly Trp Ala Gly Trp 
                85                  90                  95      


Leu Leu Ser Pro Arg Gly Ser Arg Pro Ser Trp Gly Pro Thr Asp Pro 
            100                 105                 110         


Arg Arg Arg Ser Arg Asn Leu Gly Lys Val Ile Asp Thr Leu Thr Cys 
        115                 120                 125             


Gly Phe Ala Asp Leu Met Gly Tyr Ile Pro Leu Val Gly Ala Pro Leu 
    130                 135                 140                 


Gly Gly Thr Ala Arg Ala Leu Ala His Gly Val Arg Val Leu Glu Asp 
145                 150                 155                 160 


Gly Val Asn Tyr Ala Thr Gly Asn Leu Pro Gly Cys Ser Phe Ser Ile 
                165                 170                 175     


Phe Leu Leu Ala Leu Leu Ser Cys Leu Thr Ile Pro Ala Ser Ala Tyr 
            180                 185                 190         


Glu Val Arg Asn Val Ser Gly Val Tyr His Val Thr Asn Asp Cys Ser 
        195                 200                 205             


Asn Ser Ser Ile Val Tyr Glu Thr Ala Asp Met Ile Met His Thr Pro 
    210                 215                 220                 


Gly Cys Val Pro Cys Val Arg Glu Asp Asn Phe Thr Arg Cys Trp Val 
225                 230                 235                 240 


Ala Leu Thr Pro Thr Leu Ala Ala Arg Asn Gly Ser Val Pro Thr Thr 
                245                 250                 255     


Ala Ile Arg Arg His Val Asp Leu Leu Val Gly Ala Ala Ala Phe Cys 
            260                 265                 270         


Ser Ala Met Tyr Val Gly Asp Leu Cys Gly Ser Val Phe Leu Val Ser 
        275                 280                 285             


Gln Leu Phe Thr Phe Ser Pro Arg Trp His Glu Thr Val Gln Glu Cys 
    290                 295                 300                 


Asn Cys Ser Ile Tyr Pro Gly His Val Thr Gly His Arg Met Ala Trp 
305                 310                 315                 320 


Asp Met Met Met Asn Trp Ser Pro Thr Thr Ala Leu Val Val Ser Gln 
                325                 330                 335     


Leu Leu Arg Ile Pro Gln Ala Val Val Asp Met Val Ala Gly Ala His 
            340                 345                 350         


Trp Gly Val Leu Ala Gly Leu Ala Tyr Tyr Ser Met Val Gly Asn Trp 
        355                 360                 365             


Ala Lys Val Leu Ile Val Thr Leu Leu Phe Ala Gly Val Asp Gly Asn 
    370                 375                 380                 


Thr His Thr Ile Gly Gly Lys Gln Ala Gln Ala Thr Gly Gly Phe Val 
385                 390                 395                 400 


Ala Trp Leu Ala Arg Gly Pro Ser Gln Glu Ile Gln Leu Ile Asn Thr 
                405                 410                 415     


Asn Gly Ser Trp His Ile Asn Arg Thr Ala Leu Asn Cys Asn Asp Ser 
            420                 425                 430         


Leu Lys Thr Gly Phe Ile Ala Ala Leu Phe Tyr Ala His Arg Phe Asn 
        435                 440                 445             


Ser Ser Gly Cys Pro Glu Arg Met Ala Ser Cys Arg Pro Ile Asp Lys 
    450                 455                 460                 


Phe Ala Gln Gly Trp Gly Pro Ile Thr Tyr Ala Lys Pro Asp Ser Leu 
465                 470                 475                 480 


Asp Gln Arg Pro Tyr Cys Trp His Tyr Ala Pro Gln Pro Cys Gly Ile 
                485                 490                 495     


Val Pro Ala Ser Glu Val Cys Gly Pro Val Tyr Cys Phe Thr Pro Ser 
            500                 505                 510         


Pro Val Val Val Gly Thr Thr Asp Arg Ser Gly Val Pro Thr Tyr Arg 
        515                 520                 525             


Trp Gly Glu Asn Glu Thr Asp Val Leu Leu Leu Asn Asn Thr Arg Pro 
    530                 535                 540                 


Pro Gln Gly Asn Trp Phe Gly Cys Thr Trp Met Asn Ala Thr Gly Phe 
545                 550                 555                 560 


Thr Lys Thr Cys Gly Gly Pro Pro Cys Lys Ile Gly Gly Leu Gly Asn 
                565                 570                 575     


Asn Thr Leu Thr Cys Pro Thr Asp Cys Phe Arg Lys His Pro Glu Ala 
            580                 585                 590         


Thr Tyr Thr Lys Cys Gly Ser Gly Pro Trp Leu Thr Pro Arg Cys Ile 
        595                 600                 605             


Val Asp Tyr Pro Tyr Arg Leu Trp His Tyr Pro Cys Thr Val Asn Phe 
    610                 615                 620                 


Thr Ile Phe Lys Val Arg Met Tyr Val Gly Gly Ile Glu His Arg Leu 
625                 630                 635                 640 


Ser Ala Ala Cys Asn Trp Thr Arg Gly Glu Arg Cys Asp Leu Glu Asp 
                645                 650                 655     


Arg Asp Arg Ser Glu Leu Ser Pro Leu Leu Leu Ser Thr Thr Glu Trp 
            660                 665                 670         


Gln Ile Leu Pro Cys Ser Phe Thr Thr Leu Pro Ala Leu Ser Thr Gly 
        675                 680                 685             


Leu Ile His Leu His Gln Asn Thr Val Asp Val Gln Tyr Leu Tyr Gly 
    690                 695                 700                 


Val Gly Ser Val Leu Val Ser Phe Ala Ile Lys Trp Glu Tyr Ile Leu 
705                 710                 715                 720 


Leu Phe Phe Leu Leu Leu Ala Asp Ala Arg Val Cys Ala Cys Leu Trp 
                725                 730                 735     


Met Met Leu Leu Ile Ala Gln Ala Glu Ala 
            740                 745     


<210>  27
<211>  746
<212>  PRT
<213>  Hepatitis C virus

<400>  27

Met Ser Thr Asn Pro Lys Pro Gln Arg Lys Thr Lys Arg Asn Thr Asn 
1               5                   10                  15      


Arg Arg Pro Gln Asn Val Lys Phe Pro Gly Gly Gly Gln Ile Val Gly 
            20                  25                  30          


Gly Val Cys Leu Leu Pro Arg Arg Gly Pro Arg Val Gly Val Arg Ala 
        35                  40                  45              


Thr Arg Lys Thr Ser Glu Arg Ser Gln Pro Arg Gly Arg Arg Gln Pro 
    50                  55                  60                  


Ile Pro Lys Ala Arg Arg Pro Glu Gly Arg Ser Trp Ala Gln Pro Gly 
65                  70                  75                  80  


Tyr Pro Trp Pro Leu Tyr Gly Asn Glu Gly Cys Gly Trp Ala Gly Trp 
                85                  90                  95      


Leu Leu Ser Pro Arg Gly Ser Arg Pro Ser Arg Gly Pro Ser Asp Pro 
            100                 105                 110         


Arg Arg Arg Ser Arg Asn Leu Gly Lys Val Ile Asp Thr Leu Thr Cys 
        115                 120                 125             


Gly Phe Ala Asp Leu Met Gly Tyr Ile Pro Leu Val Gly Ala Pro Leu 
    130                 135                 140                 


Gly Gly Ala Ala Arg Ala Leu Ala His Gly Val Arg Val Leu Glu Asp 
145                 150                 155                 160 


Gly Val Asn Tyr Ala Thr Gly Asn Leu Pro Gly Cys Ser Phe Ser Ile 
                165                 170                 175     


Phe Leu Leu Ala Leu Leu Ser Cys Leu Thr Val Pro Ala Ser Ala Val 
            180                 185                 190         


Glu Val Arg Asn Ser Ser Gly Ile Tyr His Val Thr Asn Asp Cys Pro 
        195                 200                 205             


Asn Ala Ser Val Val Tyr Glu Thr Asp Ser Leu Ile Ile His Leu Pro 
    210                 215                 220                 


Gly Cys Val Pro Cys Val Arg Glu Gly Asn Ala Ser Arg Cys Trp Val 
225                 230                 235                 240 


Ser Leu Ser Pro Thr Val Ala Ala Lys Asp Pro Gly Val Pro Val Asn 
                245                 250                 255     


Glu Ile Arg Arg His Val Asp Leu Ile Val Gly Ala Ala Ala Phe Cys 
            260                 265                 270         


Ser Ala Met Tyr Val Gly Asp Leu Cys Gly Ser Ile Phe Leu Val Gly 
        275                 280                 285             


Gln Leu Phe Thr Leu Ser Pro Arg Arg His Trp Thr Thr Gln Asp Cys 
    290                 295                 300                 


Asn Cys Ser Ile Tyr Pro Gly His Val Thr Gly His Arg Met Ala Trp 
305                 310                 315                 320 


Asp Met Met Met Asn Trp Ser Pro Thr Gly Ala Leu Val Val Ala Gln 
                325                 330                 335     


Leu Leu Arg Ile Pro Gln Ala Val Leu Asp Met Ile Ala Gly Ala His 
            340                 345                 350         


Trp Gly Val Leu Ala Gly Pro Ala Tyr Tyr Ser Met Val Gly Asn Trp 
        355                 360                 365             


Ala Lys Val Leu Val Val Leu Leu Leu Phe Ala Gly Val Asp Ala Thr 
    370                 375                 380                 


Thr Gln Val Thr Gly Gly Thr Ala Gly Arg Asn Ala Tyr Arg Leu Ala 
385                 390                 395                 400 


Ser Leu Phe Ser Thr Gly Pro Ser Gln Asn Ile Gln Leu Ile Asn Ser 
                405                 410                 415     


Asn Gly Ser Trp His Ile Asn Arg Thr Ala Leu Asn Cys Asn Asp Ser 
            420                 425                 430         


Leu His Thr Gly Trp Val Ala Ala Leu Phe Tyr Ser His Lys Phe Asn 
        435                 440                 445             


Ser Ser Gly Arg Pro Glu Arg Met Ala Ser Cys Arg Pro Leu Thr Ala 
    450                 455                 460                 


Phe Asp Gln Gly Trp Gly Pro Ile Thr Tyr Gly Gly Lys Ala Ser Asn 
465                 470                 475                 480 


Asp Gln Arg Pro Tyr Cys Trp His Tyr Ala Pro Arg Pro Cys Gly Ile 
                485                 490                 495     


Val Pro Ala Lys Glu Val Cys Gly Pro Val Tyr Cys Phe Thr Pro Ser 
            500                 505                 510         


Pro Val Val Val Gly Thr Thr Asp Lys Tyr Gly Val Pro Thr Tyr Thr 
        515                 520                 525             


Trp Gly Glu Asn Glu Thr Asp Val Leu Leu Leu Asn Asn Ser Arg Pro 
    530                 535                 540                 


Pro Ile Gly Asn Trp Phe Gly Cys Thr Trp Met Asn Ser Thr Gly Phe 
545                 550                 555                 560 


Thr Lys Thr Cys Gly Ala Pro Ala Cys Asn Val Gly Gly Ser Glu Thr 
                565                 570                 575     


Asn Thr Leu Ser Cys Pro Thr Asp Cys Phe Arg Arg His Pro Asp Ala 
            580                 585                 590         


Thr Tyr Ala Lys Cys Gly Ser Gly Pro Trp Leu Asn Pro Arg Cys Met 
        595                 600                 605             


Val Asp Tyr Pro Tyr Arg Leu Trp His Tyr Pro Cys Thr Val Asn Tyr 
    610                 615                 620                 


Thr Ile Phe Lys Ile Arg Met Phe Val Gly Gly Ile Glu His Arg Leu 
625                 630                 635                 640 


Thr Ala Ala Cys Asn Trp Thr Arg Gly Glu Arg Cys Asp Leu Asp Asp 
                645                 650                 655     


Arg Asp Arg Ala Glu Leu Ser Pro Leu Leu Leu Ser Thr Thr Gln Trp 
            660                 665                 670         


Gln Val Leu Pro Cys Ser Phe Thr Thr Leu Pro Ala Leu Ser Thr Gly 
        675                 680                 685             


Leu Ile His Leu His Gln Asn Ile Val Asp Val Gln Tyr Leu Tyr Gly 
    690                 695                 700                 


Leu Ser Ser Val Val Thr Ser Trp Ala Ile Arg Trp Glu Tyr Val Val 
705                 710                 715                 720 


Leu Leu Phe Leu Leu Leu Ala Asp Ala Arg Ile Cys Ala Cys Leu Trp 
                725                 730                 735     


Met Met Leu Leu Ile Ser Gln Val Glu Ala 
            740                 745     


<210>  28
<211>  746
<212>  PRT
<213>  Hepatitis C virus

<400>  28

Met Ser Thr Asn Pro Lys Pro Gln Arg Lys Thr Lys Arg Asn Thr Asn 
1               5                   10                  15      


Arg Arg Pro Gln Asp Val Lys Phe Pro Gly Gly Gly Gln Ile Val Gly 
            20                  25                  30          


Gly Val Tyr Leu Leu Pro Arg Arg Gly Pro Arg Leu Gly Val Arg Ala 
        35                  40                  45              


Thr Arg Lys Thr Ser Glu Arg Ser Gln Pro Arg Gly Arg Arg Gln Pro 
    50                  55                  60                  


Ile Pro Lys Ala Arg Arg Pro Glu Gly Arg Thr Trp Ala Gln Pro Gly 
65                  70                  75                  80  


Tyr Pro Trp Pro Leu Tyr Gly Asn Glu Gly Cys Gly Trp Ala Gly Trp 
                85                  90                  95      


Leu Leu Ser Pro Arg Gly Ser Arg Pro Ser Trp Gly Pro Thr Asp Pro 
            100                 105                 110         


Arg Arg Arg Ser Arg Asn Leu Gly Lys Val Ile Asp Thr Leu Thr Tyr 
        115                 120                 125             


Gly Phe Ala Asp Leu Met Gly Tyr Ile Pro Leu Val Gly Ala Pro Leu 
    130                 135                 140                 


Gly Gly Ala Ala Arg Ala Leu Ala His Gly Val Arg Val Leu Glu Asp 
145                 150                 155                 160 


Gly Val Asn Tyr Ala Thr Gly Asn Leu Pro Gly Cys Ser Phe Ser Ile 
                165                 170                 175     


Phe Leu Leu Ala Leu Leu Ser Cys Leu Thr Val Pro Ala Ser Ala Val 
            180                 185                 190         


Gly Val Arg Asn Ser Ser Gly Val Tyr His Val Thr Asn Asp Cys Pro 
        195                 200                 205             


Asn Ala Ser Val Val Tyr Glu Thr Asp Ser Leu Ile Ile His Leu Pro 
    210                 215                 220                 


Gly Cys Val Pro Cys Val Arg Glu Gly Asn Gly Ser Arg Cys Trp Val 
225                 230                 235                 240 


Ser Leu Ser Pro Thr Val Ala Ala Lys Asp Pro Gly Val Pro Val Asn 
                245                 250                 255     


Glu Ile Arg Arg His Val Asp Leu Ile Ala Gly Ala Ala Ala Phe Cys 
            260                 265                 270         


Ser Ala Met Tyr Val Gly His Leu Cys Gly Ser Ile Phe Leu Val Gly 
        275                 280                 285             


Gln Leu Phe Thr Leu Ser Pro Arg Arg His Trp Thr Thr Gln Asp Cys 
    290                 295                 300                 


Asn Cys Ser Ile Tyr Pro Gly His Val Thr Gly His Arg Met Ala Trp 
305                 310                 315                 320 


Asp Met Met Met Asn Trp Ser Pro Thr Thr Ala Leu Val Val Ala Gln 
                325                 330                 335     


Leu Leu Arg Ile Pro Gln Ala Ile Leu Asp Met Ile Ala Gly Ala His 
            340                 345                 350         


Trp Gly Val Leu Ala Gly Ile Ala Tyr Phe Ser Met Val Gly Asn Trp 
        355                 360                 365             


Thr Lys Val Leu Val Val Leu Leu Leu Phe Ala Gly Val Asp Ala Thr 
    370                 375                 380                 


Thr Ile Val Ser Gly Gly Ser Ala Gly Arg Ser Thr Ala Gly Leu Val 
385                 390                 395                 400 


Gly Leu Phe Ser Pro Gly Ala Arg Gln Asn Ile Gln Leu Ile Asn Thr 
                405                 410                 415     


Asn Gly Ser Trp His Ile Asn Arg Thr Ala Leu Asn Cys Asn Asp Thr 
            420                 425                 430         


Leu Gln Thr Gly Trp Val Ala Gly Leu Phe Tyr Thr Asn Lys Phe Asn 
        435                 440                 445             


Ser Ser Gly Cys Pro Glu Arg Leu Ala Ser Cys Arg Pro Leu Ala Asp 
    450                 455                 460                 


Phe Asp Gln Gly Trp Gly Pro Ile Ser Tyr Thr Asn Gly Ser Gly Pro 
465                 470                 475                 480 


Asp Gln Arg Pro Tyr Cys Trp His Tyr Pro Pro Lys Pro Cys Gly Ile 
                485                 490                 495     


Val Pro Ala Glu Ser Val Cys Gly Pro Val Tyr Cys Phe Thr Pro Ser 
            500                 505                 510         


Pro Val Val Val Gly Thr Thr Asp Arg Ser Gly Ala Pro Thr Tyr Asn 
        515                 520                 525             


Trp Gly Glu Asn Glu Thr Asp Val Phe Val Leu Asn Asn Thr Arg Pro 
    530                 535                 540                 


Arg Leu Gly Asn Trp Phe Gly Gly Thr Trp Met Asn Ser Thr Gly Phe 
545                 550                 555                 560 


Thr Lys Val Cys Gly Ala Pro Pro Cys Ala Ile Gly Gly Val Gly Asn 
                565                 570                 575     


Asn Thr Leu Tyr Cys Pro Thr Asp Cys Phe Arg Lys His Pro Glu Ala 
            580                 585                 590         


Thr Tyr Ser Arg Cys Gly Ser Gly Pro Trp Ile Thr Pro Arg Cys Leu 
        595                 600                 605             


Ile His Tyr Pro Tyr Arg Leu Trp His Tyr Pro Cys Thr Ile Asn Tyr 
    610                 615                 620                 


Thr Ile Phe Lys Ile Arg Met Phe Val Gly Gly Val Glu His Arg Leu 
625                 630                 635                 640 


Asp Ala Ala Cys Asn Trp Thr Arg Gly Glu Arg Cys Asp Leu Asp Asp 
                645                 650                 655     


Arg Asp Arg Ala Glu Leu Ser Pro Leu Leu Leu Ser Thr Thr Gln Trp 
            660                 665                 670         


Gln Val Leu Pro Cys Ser Phe Thr Thr Leu Pro Ala Leu Ser Thr Gly 
        675                 680                 685             


Leu Ile His Leu His Gln Asn Ile Val Asp Val Gln Tyr Leu Tyr Gly 
    690                 695                 700                 


Leu Ser Ser Ala Val Thr Ser Trp Val Ile Lys Trp Glu Tyr Val Val 
705                 710                 715                 720 


Leu Leu Phe Leu Leu Leu Ala Asp Ala Arg Ile Cys Ala Cys Leu Trp 
                725                 730                 735     


Met Met Leu Leu Ile Ser Gln Val Glu Ala 
            740                 745     


<210>  29
<211>  746
<212>  PRT
<213>  Hepatitis C virus

<400>  29

Met Ser Thr Asn Pro Lys Pro Gln Arg Lys Thr Lys Arg Asn Thr Asn 
1               5                   10                  15      


Arg Arg Pro Gln Asp Val Lys Phe Pro Gly Gly Gly Gln Ile Val Gly 
            20                  25                  30          


Gly Val Tyr Leu Leu Pro Arg Arg Gly Pro Arg Val Gly Val Arg Ala 
        35                  40                  45              


Thr Arg Lys Thr Ser Glu Arg Ser Gln Pro Arg Gly Arg Arg Gln Pro 
    50                  55                  60                  


Ile Pro Lys Ala Arg Arg Pro Glu Gly Arg Ser Trp Ala Gln Pro Gly 
65                  70                  75                  80  


Tyr Pro Trp Pro Leu Tyr Gly Asn Glu Gly Cys Gly Trp Ala Gly Trp 
                85                  90                  95      


Leu Leu Ser Pro Arg Gly Ser Arg Pro Ser Trp Gly Pro Ser Asp Pro 
            100                 105                 110         


Arg Arg Arg Ser Arg Asn Leu Gly Lys Val Ile Asp Thr Leu Thr Cys 
        115                 120                 125             


Gly Phe Ala Asp Leu Met Gly Tyr Ile Pro Leu Val Gly Ala Pro Leu 
    130                 135                 140                 


Gly Gly Ala Ala Arg Ala Leu Ala His Gly Val Arg Val Leu Glu Asp 
145                 150                 155                 160 


Gly Val Asn Tyr Ala Thr Gly Asn Leu Pro Gly Cys Ser Phe Ser Ile 
                165                 170                 175     


Phe Leu Leu Ala Leu Leu Ser Cys Leu Thr Val Pro Ala Ser Ala Val 
            180                 185                 190         


Gly Val Arg Asn Ser Ser Gly Val Tyr His Val Thr Asn Asp Cys Pro 
        195                 200                 205             


Asn Ala Ser Val Val Tyr Glu Thr Glu Asn Leu Ile Met His Leu Pro 
    210                 215                 220                 


Gly Cys Val Pro Tyr Val Arg Glu Gly Asn Ala Ser Arg Cys Trp Val 
225                 230                 235                 240 


Ser Leu Ser Pro Thr Val Ala Ala Arg Asp Ser Arg Val Pro Val Ser 
                245                 250                 255     


Glu Val Arg Arg Arg Val Asp Ser Ile Val Gly Ala Ala Ala Phe Cys 
            260                 265                 270         


Ser Ala Met Tyr Val Gly Asp Leu Cys Gly Ser Ile Phe Leu Val Gly 
        275                 280                 285             


Gln Ile Phe Thr Phe Ser Pro Arg His His Trp Thr Thr Gln Asp Cys 
    290                 295                 300                 


Asn Cys Ser Ile Tyr Pro Gly His Val Thr Gly His Arg Met Ala Trp 
305                 310                 315                 320 


Asp Met Met Met Asn Trp Ser Pro Thr Gly Ala Leu Val Val Ala Gln 
                325                 330                 335     


Leu Leu Arg Ile Pro Gln Ala Ile Val Asp Met Ile Ala Gly Ala His 
            340                 345                 350         


Trp Gly Val Leu Ala Gly Leu Ala Tyr Tyr Ser Met Val Gly Asn Trp 
        355                 360                 365             


Ala Lys Val Val Val Val Leu Leu Leu Phe Ala Gly Val Asp Ala Glu 
    370                 375                 380                 


Thr Arg Val Thr Gly Gly Ala Ala Gly His Thr Ala Phe Gly Phe Ala 
385                 390                 395                 400 


Ser Phe Leu Ala Pro Gly Ala Lys Gln Lys Ile Gln Leu Ile Asn Thr 
                405                 410                 415     


Asn Gly Ser Trp His Ile Asn Arg Thr Ala Leu Asn Cys Asn Glu Ser 
            420                 425                 430         


Leu Asp Thr Gly Trp Leu Ala Gly Leu Leu Tyr Tyr His Lys Phe Asn 
        435                 440                 445             


Ser Ser Gly Cys Pro Glu Arg Met Ala Ser Cys Gln Pro Leu Thr Ala 
    450                 455                 460                 


Phe Asp Gln Gly Trp Gly Pro Ile Thr His Glu Gly Asn Ala Ser Asp 
465                 470                 475                 480 


Asp Gln Arg Pro Tyr Cys Trp His Tyr Ala Leu Arg Pro Cys Gly Ile 
                485                 490                 495     


Val Pro Ala Lys Lys Val Cys Gly Pro Val Tyr Cys Phe Thr Pro Ser 
            500                 505                 510         


Pro Val Val Val Gly Thr Thr Asp Arg Ala Gly Val Pro Thr Tyr Arg 
        515                 520                 525             


Trp Gly Ala Asn Glu Thr Asp Val Leu Leu Leu Asn Asn Ser Arg Pro 
    530                 535                 540                 


Pro Met Gly Asn Trp Phe Gly Cys Thr Trp Met Asn Ser Ser Gly Phe 
545                 550                 555                 560 


Thr Lys Thr Cys Gly Ala Pro Ala Cys Asn Ile Gly Gly Ser Gly Asn 
                565                 570                 575     


Asn Thr Leu Leu Cys Pro Thr Asp Cys Phe Arg Lys His Pro Asp Ala 
            580                 585                 590         


Thr Tyr Ser Arg Cys Gly Ser Gly Pro Trp Leu Thr Pro Arg Cys Leu 
        595                 600                 605             


Val Asp Tyr Pro Tyr Arg Leu Trp His Tyr Pro Cys Thr Val Asn Tyr 
    610                 615                 620                 


Thr Ile Phe Lys Ile Arg Met Phe Val Gly Gly Val Glu His Arg Leu 
625                 630                 635                 640 


Asp Ala Ala Cys Asn Trp Thr Arg Gly Glu Arg Cys Asp Leu Asp Asp 
                645                 650                 655     


Arg Asp Arg Ala Glu Leu Ser Pro Leu Leu Leu Ser Thr Thr Gln Trp 
            660                 665                 670         


Gln Val Leu Pro Cys Ser Phe Thr Thr Leu Pro Ala Leu Ser Thr Gly 
        675                 680                 685             


Leu Ile His Leu His Gln Asn Ile Val Asp Val Gln Tyr Leu Tyr Gly 
    690                 695                 700                 


Leu Ser Ser Ala Val Thr Ser Trp Val Ile Lys Trp Glu Tyr Val Val 
705                 710                 715                 720 


Leu Leu Phe Leu Leu Leu Ala Asp Ala Arg Ile Cys Ala Cys Leu Trp 
                725                 730                 735     


Met Met Leu Leu Ile Ser Gln Val Glu Ala 
            740                 745     


<210>  30
<211>  750
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Sequence


<220>
<221>  misc_feature
<222>  (233)..(233)
<223>  Xaa can be any amino acid

<220>
<221>  misc_feature
<222>  (249)..(250)
<223>  Xaa can be any amino acid

<220>
<221>  misc_feature
<222>  (290)..(290)
<223>  Xaa can be any amino acid

<220>
<221>  misc_feature
<222>  (378)..(378)
<223>  Xaa can be any amino acid

<220>
<221>  misc_feature
<222>  (392)..(392)
<223>  Xaa can be any amino acid

<220>
<221>  misc_feature
<222>  (399)..(399)
<223>  Xaa can be any amino acid

<220>
<221>  misc_feature
<222>  (445)..(445)
<223>  Xaa can be any amino acid

<220>
<221>  misc_feature
<222>  (495)..(495)
<223>  Xaa can be any amino acid

<220>
<221>  misc_feature
<222>  (599)..(599)
<223>  Xaa can be any amino acid

<220>
<221>  misc_feature
<222>  (628)..(628)
<223>  Xaa can be any amino acid

<220>
<221>  misc_feature
<222>  (664)..(664)
<223>  Xaa can be any amino acid

<220>
<221>  misc_feature
<222>  (683)..(683)
<223>  Xaa can be any amino acid

<400>  30

Met Ser Thr Asn Pro Lys Pro Gln Arg Lys Thr Lys Arg Asn Thr Asn 
1               5                   10                  15      


Arg Arg Pro Gln Asp Val Lys Phe Pro Gly Gly Gly Gln Ile Val Gly 
            20                  25                  30          


Gly Val Tyr Leu Leu Pro Arg Arg Gly Pro Arg Leu Gly Val Arg Ala 
        35                  40                  45              


Thr Arg Lys Thr Ser Glu Arg Ser Gln Pro Arg Gly Arg Arg Gln Pro 
    50                  55                  60                  


Ile Pro Lys Asp Arg Arg Ser Thr Gly Lys Ser Trp Gly Lys Pro Gly 
65                  70                  75                  80  


Tyr Pro Trp Pro Leu Tyr Gly Asn Glu Gly Leu Gly Trp Ala Gly Trp 
                85                  90                  95      


Leu Leu Ser Pro Arg Gly Ser Arg Pro Ser Trp Gly Pro Thr Asp Pro 
            100                 105                 110         


Arg His Arg Ser Arg Asn Val Gly Lys Val Ile Asp Thr Leu Thr Cys 
        115                 120                 125             


Gly Phe Ala Asp Leu Met Gly Tyr Ile Pro Val Val Gly Ala Pro Leu 
    130                 135                 140                 


Gly Gly Val Ala Arg Ala Leu Ala His Gly Val Arg Val Leu Glu Asp 
145                 150                 155                 160 


Gly Val Asn Tyr Ala Thr Gly Asn Leu Pro Gly Cys Ser Phe Ser Ile 
                165                 170                 175     


Phe Leu Leu Ala Leu Leu Ser Cys Ile Thr Val Pro Val Ser Ala Val 
            180                 185                 190         


Glu Val Lys Asn Ile Ser Thr Ser Tyr Met Val Thr Asn Asp Cys Ser 
        195                 200                 205             


Asn Asp Ser Ile Thr Trp Gln Leu Gln Ala Ala Val Leu His Val Pro 
    210                 215                 220                 


Gly Cys Val Pro Cys Glu Asn Asp Xaa Asn Thr Ser Arg Cys Trp Ile 
225                 230                 235                 240 


Pro Val Ser Pro Asn Val Ala Val Xaa Xaa Pro Gly Ala Leu Thr Gln 
                245                 250                 255     


Gly Leu Arg Thr His Ile Asp Met Val Val Met Ser Ala Thr Leu Cys 
            260                 265                 270         


Ser Ala Leu Tyr Val Gly Asp Leu Cys Gly Gly Val Met Leu Ala Ala 
        275                 280                 285             


Gln Xaa Phe Ile Val Ser Pro Gln Arg His Trp Phe Val Gln Glu Cys 
    290                 295                 300                 


Asn Cys Ser Ile Tyr Pro Gly Thr Ile Thr Gly His Arg Met Ala Trp 
305                 310                 315                 320 


Asp Met Met Met Asn Trp Ser Pro Thr Ala Thr Met Ile Leu Ala Tyr 
                325                 330                 335     


Ala Met Arg Val Pro Glu Val Ile Ile Asp Ile Ile Phe Gly Ala His 
            340                 345                 350         


Trp Gly Val Met Phe Gly Leu Ala Tyr Phe Ser Met Gln Gly Ala Trp 
        355                 360                 365             


Ala Lys Val Ile Val Ile Leu Leu Leu Xaa Ala Gly Val Asp Ala Arg 
    370                 375                 380                 


Thr His Thr Val Gly Gly Ser Xaa Gly Arg Thr Thr Ser Gly Xaa Ala 
385                 390                 395                 400 


Gly Leu Phe Ser Ser Gly Pro Lys Gln Asn Ile Gln Leu Ile Asn Thr 
                405                 410                 415     


Asn Gly Ser Trp His Ile Asn Arg Thr Ala Leu Asn Cys Asn Asp Ser 
            420                 425                 430         


Leu Gln Thr Gly Phe Ile Ala Ser Leu Phe Tyr Thr Xaa Asn Phe Asn 
        435                 440                 445             


Ser Ser Gly Cys Pro Glu Arg Leu Ser Ala Cys Arg Gly Ile Glu Ala 
    450                 455                 460                 


Phe Arg Ile Gly Trp Gly Thr Leu Gln Tyr Glu Asp Asn Val Thr Asn 
465                 470                 475                 480 


Pro Glu Asp Met Arg Pro Tyr Cys Trp His Tyr Pro Pro Lys Xaa Cys 
                485                 490                 495     


Gly Ile Val Pro Ala Arg Ser Val Cys Gly Pro Val Tyr Cys Phe Thr 
            500                 505                 510         


Pro Ser Pro Val Val Val Gly Thr Thr Asp Arg Leu Gly Val Pro Thr 
        515                 520                 525             


Tyr Thr Trp Gly Glu Asn Glu Thr Asp Val Phe Leu Leu Asn Ser Thr 
    530                 535                 540                 


Arg Pro Pro Arg Gly Ser Trp Phe Gly Cys Thr Trp Met Asn Ser Thr 
545                 550                 555                 560 


Gly Phe Thr Lys Thr Cys Gly Ala Pro Pro Cys Arg Ile Arg Ala Asp 
                565                 570                 575     


Phe Asn Ala Ser Thr Asp Leu Leu Cys Pro Thr Asp Cys Phe Arg Lys 
            580                 585                 590         


His Pro Asp Ala Thr Tyr Xaa Lys Cys Gly Ser Gly Pro Trp Leu Thr 
        595                 600                 605             


Pro Arg Cys Leu Val Asp Tyr Pro Tyr Arg Leu Trp His Tyr Pro Cys 
    610                 615                 620                 


Thr Val Asn Xaa Thr Ile Phe Lys Ile Arg Met Tyr Val Gly Gly Val 
625                 630                 635                 640 


Glu His Arg Leu Thr Ala Ala Cys Asn Phe Thr Arg Gly Asp Arg Cys 
                645                 650                 655     


Asn Leu Glu Asp Arg Asp Arg Xaa Gln Leu Ser Pro Leu Leu His Ser 
            660                 665                 670         


Thr Thr Glu Trp Ala Ile Leu Pro Cys Ser Xaa Ser Asp Leu Pro Ala 
        675                 680                 685             


Leu Ser Thr Gly Leu Leu His Leu His Gln Asn Ile Val Asp Val Gln 
    690                 695                 700                 


Tyr Met Tyr Gly Leu Ser Pro Ala Leu Thr Lys Tyr Ile Val Arg Trp 
705                 710                 715                 720 


Glu Trp Val Val Leu Leu Phe Leu Leu Leu Ala Asp Ala Arg Val Cys 
                725                 730                 735     


Ala Cys Leu Trp Met Leu Ile Leu Leu Gly Gln Ala Glu Ala 
            740                 745                 750 


<210>  31
<211>  750
<212>  PRT
<213>  Hepatitis C virus

<400>  31

Met Ser Thr Asn Pro Lys Pro Gln Arg Lys Thr Lys Arg Asn Thr Asn 
1               5                   10                  15      


Arg Arg Pro Glu Asp Val Lys Phe Pro Gly Gly Gly Gln Ile Val Gly 
            20                  25                  30          


Gly Val Tyr Leu Leu Pro Arg Arg Gly Pro Arg Leu Gly Val Arg Thr 
        35                  40                  45              


Thr Arg Lys Thr Ser Glu Arg Ser Gln Pro Arg Gly Arg Arg Gln Pro 
    50                  55                  60                  


Ile Pro Lys Asp Arg Arg Ser Thr Gly Lys Ala Trp Gly Lys Pro Gly 
65                  70                  75                  80  


Arg Pro Trp Pro Leu Tyr Gly Asn Glu Gly Leu Gly Trp Ala Gly Trp 
                85                  90                  95      


Leu Leu Ser Pro Arg Gly Ser Arg Pro Ser Trp Gly Pro Thr Asp Pro 
            100                 105                 110         


Arg His Arg Ser Arg Asn Val Gly Lys Val Ile Asp Thr Leu Thr Cys 
        115                 120                 125             


Gly Phe Ala Asp Leu Met Gly Tyr Ile Pro Val Val Gly Ala Pro Leu 
    130                 135                 140                 


Ser Gly Ala Ala Arg Ala Val Ala His Gly Val Arg Val Leu Glu Asp 
145                 150                 155                 160 


Gly Val Asn Tyr Ala Thr Gly Asn Leu Pro Gly Phe Pro Phe Ser Ile 
                165                 170                 175     


Phe Leu Leu Ala Leu Leu Ser Cys Ile Thr Val Pro Val Ser Ala Ala 
            180                 185                 190         


Gln Val Lys Asn Thr Ser Ser Ser Tyr Met Val Thr Asn Asp Cys Ser 
        195                 200                 205             


Asn Asp Ser Ile Thr Trp Gln Leu Glu Ala Ala Val Leu His Val Pro 
    210                 215                 220                 


Gly Cys Val Pro Cys Glu Arg Val Gly Asn Thr Ser Arg Cys Trp Val 
225                 230                 235                 240 


Pro Val Ser Pro Asn Met Ala Val Arg Gln Pro Gly Ala Leu Thr Gln 
                245                 250                 255     


Gly Leu Arg Thr His Ile Asp Met Val Val Met Ser Ala Thr Phe Cys 
            260                 265                 270         


Ser Ala Leu Tyr Val Gly Asp Leu Cys Gly Gly Val Met Leu Ala Ala 
        275                 280                 285             


Gln Val Phe Ile Val Ser Pro Gln Tyr His Trp Phe Val Gln Glu Cys 
    290                 295                 300                 


Asn Cys Ser Ile Tyr Pro Gly Thr Ile Thr Gly His Arg Met Ala Trp 
305                 310                 315                 320 


Asp Met Met Met Asn Trp Ser Pro Thr Ala Thr Met Ile Leu Ala Tyr 
                325                 330                 335     


Val Met Arg Val Pro Glu Val Ile Ile Asp Ile Val Ser Gly Ala His 
            340                 345                 350         


Trp Gly Val Met Phe Gly Leu Ala Tyr Phe Ser Met Gln Gly Ala Trp 
        355                 360                 365             


Ala Lys Val Ile Val Ile Leu Leu Leu Ala Ala Gly Val Asp Ala Gly 
    370                 375                 380                 


Thr Thr Thr Val Gly Gly Ala Val Ala Arg Ser Thr Asn Val Ile Ala 
385                 390                 395                 400 


Gly Val Phe Ser His Gly Pro Gln Gln Asn Ile Gln Leu Ile Asn Thr 
                405                 410                 415     


Asn Gly Ser Trp His Ile Asn Arg Thr Ala Leu Asn Cys Asn Asp Ser 
            420                 425                 430         


Leu Asn Thr Gly Phe Leu Ala Ala Leu Phe Tyr Thr Asn Arg Phe Asn 
        435                 440                 445             


Ser Ser Gly Cys Pro Gly Arg Leu Ser Ala Cys Arg Asn Ile Glu Ala 
    450                 455                 460                 


Phe Arg Ile Gly Trp Gly Thr Leu Gln Tyr Glu Asp Asn Val Thr Asn 
465                 470                 475                 480 


Pro Glu Asp Met Arg Pro Tyr Cys Trp His Tyr Pro Pro Lys Pro Cys 
                485                 490                 495     


Gly Val Val Pro Ala Arg Ser Val Cys Gly Pro Val Tyr Cys Phe Thr 
            500                 505                 510         


Pro Ser Pro Val Val Val Gly Thr Thr Asp Arg Arg Gly Val Pro Thr 
        515                 520                 525             


Tyr Thr Trp Gly Glu Asn Glu Thr Asp Val Phe Leu Leu Asn Ser Thr 
    530                 535                 540                 


Arg Pro Pro Gln Gly Ser Trp Phe Gly Cys Thr Trp Met Asn Ser Thr 
545                 550                 555                 560 


Gly Phe Thr Lys Thr Cys Gly Ala Pro Pro Cys Arg Thr Arg Ala Asp 
                565                 570                 575     


Phe Asn Ala Ser Thr Asp Leu Leu Cys Pro Thr Asp Cys Phe Arg Lys 
            580                 585                 590         


His Pro Asp Ala Thr Tyr Ile Lys Cys Gly Ser Gly Pro Trp Leu Thr 
        595                 600                 605             


Pro Lys Cys Leu Val His Tyr Pro Tyr Arg Leu Trp His Tyr Pro Cys 
    610                 615                 620                 


Thr Val Asn Phe Thr Ile Phe Lys Ile Arg Met Tyr Val Gly Gly Val 
625                 630                 635                 640 


Glu His Arg Leu Thr Ala Ala Cys Asn Phe Thr Arg Gly Asp Arg Cys 
                645                 650                 655     


Asp Leu Glu Asp Arg Asp Arg Ser Gln Leu Ser Pro Leu Leu His Ser 
            660                 665                 670         


Thr Thr Glu Trp Ala Ile Leu Pro Cys Thr Tyr Ser Asp Leu Pro Ala 
        675                 680                 685             


Leu Ser Thr Gly Leu Leu His Leu His Gln Asn Ile Val Asp Val Gln 
    690                 695                 700                 


Tyr Met Tyr Gly Leu Ser Pro Ala Ile Thr Lys Tyr Val Val Arg Trp 
705                 710                 715                 720 


Glu Trp Val Val Leu Leu Phe Leu Leu Leu Ala Asp Ala Arg Val Cys 
                725                 730                 735     


Ala Cys Leu Trp Met Leu Ile Leu Leu Gly Gln Ala Glu Ala 
            740                 745                 750 


<210>  32
<211>  749
<212>  PRT
<213>  Hepatitis C virus

<400>  32

Met Ser Thr Asn Pro Lys Pro Gln Arg Lys Thr Lys Arg Asn Thr Asn 
1               5                   10                  15      


Arg Arg Pro Gln Asp Val Lys Phe Pro Gly Gly Gly Gln Ile Val Gly 
            20                  25                  30          


Gly Val Tyr Leu Leu Pro Arg Arg Gly Pro Arg Leu Gly Val Arg Ala 
        35                  40                  45              


Thr Arg Lys Thr Ser Glu Arg Ser Gln Pro Arg Gly Arg Arg Gln Pro 
    50                  55                  60                  


Ile Pro Lys Asp Arg Arg Ser Thr Gly Lys Ser Trp Gly Lys Pro Gly 
65                  70                  75                  80  


Tyr Pro Trp Pro Leu Tyr Gly Asn Glu Gly Leu Gly Trp Ala Gly Trp 
                85                  90                  95      


Leu Leu Ser Pro Arg Gly Ser Arg Pro Ser Trp Gly Pro Thr Asp Pro 
            100                 105                 110         


Arg His Arg Ser Arg Asn Val Gly Lys Val Ile Asp Thr Leu Thr Cys 
        115                 120                 125             


Gly Phe Ala Asp Leu Met Gly Tyr Ile Pro Val Val Gly Ala Pro Leu 
    130                 135                 140                 


Gly Gly Val Ala Arg Ala Leu Ala His Gly Val Arg Val Leu Glu Asp 
145                 150                 155                 160 


Gly Val Asn Tyr Ala Thr Gly Asn Leu Pro Gly Cys Ser Phe Ser Ile 
                165                 170                 175     


Phe Leu Leu Ala Leu Leu Ser Cys Ile Thr Thr Pro Val Ser Ala Ala 
            180                 185                 190         


Gln Val Lys Asn Thr Ser Asp Ile Tyr Met Val Thr Asn Asp Cys Ser 
        195                 200                 205             


Asn Asp Ser Ile Thr Trp Gln Leu Gln Ala Ala Ala Leu His Val Pro 
    210                 215                 220                 


Gly Cys Val Pro Cys Glu Arg Val Gly Asn Thr Ser Arg Cys Trp Ile 
225                 230                 235                 240 


Pro Val Ser Pro Asn Val Ala Val Arg Gln Pro Gly Ala Leu Thr Gln 
                245                 250                 255     


Gly Leu Arg Thr His Ile Asp Met Val Val Met Ser Ala Thr Leu Cys 
            260                 265                 270         


Ser Ala Leu Tyr Val Gly Asp Leu Cys Gly Gly Val Met Leu Ala Ala 
        275                 280                 285             


Gln Met Phe Ile Ile Ser Pro Gln His His Trp Phe Val Gln Glu Cys 
    290                 295                 300                 


Asn Cys Ser Ile Tyr Pro Gly Thr Ile Thr Gly His Arg Met Ala Trp 
305                 310                 315                 320 


Asp Met Met Met Asn Trp Ser Pro Thr Thr Thr Met Ile Leu Ala Tyr 
                325                 330                 335     


Val Met Arg Val Pro Glu Val Ile Ile Asp Ile Ile Gly Gly Ala His 
            340                 345                 350         


Trp Gly Val Met Phe Gly Leu Ala Tyr Phe Ser Met Gln Gly Ala Trp 
        355                 360                 365             


Ala Lys Val Val Val Ile Leu Leu Leu Ala Ala Gly Val Asp Ala His 
    370                 375                 380                 


Thr Arg Thr Gly Ser Ser Val Gly Tyr Ala Thr Ser Gly Ile Val Gly 
385                 390                 395                 400 


Leu Phe Thr Ser Gly Pro Lys Gln Asn Ile Gln Leu Ile Asn Thr Asn 
                405                 410                 415     


Gly Ser Trp His Ile Asn Arg Thr Ala Leu Asn Cys Asn Asp Ser Leu 
            420                 425                 430         


Asn Thr Gly Phe Ile Val Ser Leu Phe Tyr Ala Arg Asn Phe Asn Ser 
        435                 440                 445             


Thr Gly Cys Pro Glu Arg Leu Ser Ala Cys Arg Gly Ile Glu Gly Phe 
    450                 455                 460                 


Arg Ile Gly Trp Gly Thr Leu Gln Tyr Glu Asp Asn Val Thr Asn Pro 
465                 470                 475                 480 


Glu Asp Met Arg Pro Tyr Cys Trp His Tyr Pro Pro Lys Gln Cys Gly 
                485                 490                 495     


Ile Val Pro Ala Gly Ser Val Cys Gly Pro Val Tyr Cys Phe Thr Pro 
            500                 505                 510         


Ser Pro Val Val Val Gly Thr Thr Asp Arg Leu Gly Val Pro Thr Tyr 
        515                 520                 525             


Thr Trp Gly Glu Asn Glu Thr Asp Val Phe Leu Leu Asn Ser Thr Arg 
    530                 535                 540                 


Pro Pro Val Gly Ser Trp Phe Gly Cys Thr Trp Met Asn Ser Thr Gly 
545                 550                 555                 560 


Phe Thr Lys Thr Cys Gly Ala Pro Pro Cys Arg Ile Arg Ala Asp Phe 
                565                 570                 575     


Asn Ala Ser Thr Asp Leu Leu Cys Pro Thr Asp Cys Phe Arg Lys His 
            580                 585                 590         


Pro Glu Ala Thr Tyr Ile Lys Cys Gly Ser Gly Pro Trp Leu Thr Pro 
        595                 600                 605             


Arg Cys Leu Val Asp Tyr Pro Tyr Arg Leu Trp His Tyr Pro Cys Thr 
    610                 615                 620                 


Val Asn Tyr Ser Ile Phe Lys Ile Arg Met Tyr Val Gly Gly Val Glu 
625                 630                 635                 640 


His Arg Leu Thr Ala Ala Cys Asn Phe Thr Arg Gly Asp Arg Cys Asn 
                645                 650                 655     


Leu Glu Asp Arg Asp Arg Ser Gln Leu Thr Pro Leu Leu His Ser Thr 
            660                 665                 670         


Thr Glu Trp Ala Ile Leu Pro Cys Thr Tyr Ser Asp Leu Pro Ala Leu 
        675                 680                 685             


Ser Thr Gly Leu Leu His Leu His Gln Asn Ile Val Asp Val Gln Tyr 
    690                 695                 700                 


Met Tyr Gly Leu Ser Pro Ala Leu Thr Lys Tyr Val Val Arg Trp Glu 
705                 710                 715                 720 


Trp Val Val Leu Leu Phe Leu Leu Leu Ala Asp Ala Arg Val Cys Ala 
                725                 730                 735     


Cys Val Trp Met Leu Ile Leu Leu Gly Gln Ala Glu Ala 
            740                 745                 


<210>  33
<211>  750
<212>  PRT
<213>  Hepatitis C virus


<220>
<221>  misc_feature
<222>  (458)..(458)
<223>  Xaa can be any amino acid

<400>  33

Met Ser Thr Asn Pro Lys Pro Gln Arg Lys Thr Lys Arg Asn Thr Asn 
1               5                   10                  15      


Arg Arg Pro Gln Asp Val Lys Phe Pro Gly Gly Gly Gln Ile Val Gly 
            20                  25                  30          


Gly Val Tyr Leu Leu Pro Arg Arg Gly Pro Arg Leu Gly Val Arg Ala 
        35                  40                  45              


Thr Arg Lys Thr Ser Glu Arg Ser Gln Pro Arg Gly Arg Arg Gln Pro 
    50                  55                  60                  


Ile Pro Lys Asp Arg Arg Ser Thr Gly Lys Ser Trp Gly Lys Pro Gly 
65                  70                  75                  80  


Tyr Pro Trp Pro Leu Tyr Gly Asn Glu Gly Leu Gly Trp Ala Gly Trp 
                85                  90                  95      


Leu Leu Ser Pro Arg Gly Ser Arg Pro Ser Trp Gly Pro Thr Asp Pro 
            100                 105                 110         


Arg His Arg Ser Arg Asn Val Gly Lys Val Ile Asp Thr Leu Thr Cys 
        115                 120                 125             


Gly Phe Ala Asp Leu Met Gly Tyr Ile Pro Val Val Gly Ala Pro Leu 
    130                 135                 140                 


Gly Gly Val Ala Arg Ala Leu Ala His Gly Val Arg Val Leu Glu Asp 
145                 150                 155                 160 


Gly Val Asn Tyr Ala Thr Gly Asn Leu Pro Gly Cys Ser Phe Ser Ile 
                165                 170                 175     


Phe Leu Leu Ala Leu Leu Ser Cys Val Thr Val Pro Val Ser Ala Val 
            180                 185                 190         


Gln Val Lys Asn Thr Ser Glu Thr Tyr Met Val Thr Asn Asp Cys Ser 
        195                 200                 205             


Asn Asp Ser Ile Thr Trp Gln Leu Gln Ala Ala Val Leu His Val Pro 
    210                 215                 220                 


Gly Cys Val Pro Cys Glu Arg Thr Gly Asn Thr Ser Arg Cys Trp Ile 
225                 230                 235                 240 


Pro Val Ser Pro Asn Val Ala Val Gln Gln Pro Gly Ala Leu Thr Gln 
                245                 250                 255     


Gly Leu Arg Thr His Ile Asp Met Val Val Met Ser Ala Thr Leu Cys 
            260                 265                 270         


Ser Ala Leu Tyr Val Gly Asp Leu Cys Gly Gly Val Val Leu Ala Ala 
        275                 280                 285             


Gln Leu Phe Ile Val Ser Pro Arg Arg His Trp Phe Val Gln Glu Cys 
    290                 295                 300                 


Asn Cys Ser Ile Tyr Pro Gly Ala Ile Thr Gly His Arg Met Ala Trp 
305                 310                 315                 320 


Asp Met Met Met Asn Trp Ser Pro Thr Thr Thr Met Val Leu Ala Tyr 
                325                 330                 335     


Ala Met Arg Val Pro Glu Val Ile Ile Asp Ile Ile Ser Gly Ala His 
            340                 345                 350         


Trp Gly Val Met Phe Gly Leu Ala Tyr Phe Ser Met Gln Gly Ala Trp 
        355                 360                 365             


Ala Lys Val Ala Val Ile Leu Leu Leu Thr Ala Gly Val Glu Ala Arg 
    370                 375                 380                 


Thr His Thr Thr Gly Ser Val Ala Gly Arg Thr Thr Ser Gly Phe Ala 
385                 390                 395                 400 


Gly Ile Phe Thr Ser Gly Pro Lys Gln Asn Ile Gln Leu Ile Asn Thr 
                405                 410                 415     


Asn Gly Ser Trp His Ile Asn Arg Thr Ala Leu Asn Cys Asn Asp Ser 
            420                 425                 430         


Leu Asn Thr Gly Phe Met Ala Ala Leu Phe Tyr Thr Lys Asn Phe Asn 
        435                 440                 445             


Ser Ser Gly Cys Pro Glu Arg Leu Ser Xaa Cys Arg Asn Ile Glu Ala 
    450                 455                 460                 


Phe Arg Ile Gly Trp Gly Thr Leu Gln Tyr Glu Asp Asp Val Thr Asn 
465                 470                 475                 480 


Pro Glu Asp Met Arg Pro Tyr Cys Trp His Tyr Pro Pro Lys Gln Cys 
                485                 490                 495     


Gly Ile Phe Pro Ala Gly Ser Val Cys Gly Pro Val Tyr Cys Phe Thr 
            500                 505                 510         


Pro Ser Pro Val Val Val Gly Thr Thr Asn Lys Leu Gly Val Pro Thr 
        515                 520                 525             


Tyr Thr Trp Gly Glu Asn Glu Thr Asp Val Phe Ile Leu Asn Ser Thr 
    530                 535                 540                 


Arg Pro Pro Arg Gly Ser Trp Phe Gly Cys Thr Trp Met Asn Ser Thr 
545                 550                 555                 560 


Gly Phe Thr Lys Thr Cys Gly Ala Pro Pro Cys Arg Ile Arg Ala Asp 
                565                 570                 575     


Phe Asn Ala Ser Thr Asp Leu Leu Cys Pro Thr Asp Cys Phe Arg Lys 
            580                 585                 590         


His Pro Glu Ala Thr Tyr Ile Lys Cys Gly Ser Gly Pro Trp Leu Thr 
        595                 600                 605             


Pro Arg Cys Leu Val Asp Tyr Pro Tyr Arg Leu Trp His Tyr Pro Cys 
    610                 615                 620                 


Thr Val Asn Tyr Ser Ile Phe Lys Ile Arg Met Tyr Val Gly Gly Val 
625                 630                 635                 640 


Glu His Arg Leu Thr Ala Ala Cys Asn Phe Ser Arg Gly Asp Arg Cys 
                645                 650                 655     


Asn Leu Glu Asp Arg Asp Arg Ser Gln Leu Thr Pro Leu Leu His Ser 
            660                 665                 670         


Thr Thr Glu Trp Ala Ile Leu Pro Cys Ser Tyr Ser Asp Leu Pro Ala 
        675                 680                 685             


Leu Ser Thr Gly Leu Leu His Leu His Gln Asn Ile Val Asp Val Gln 
    690                 695                 700                 


Tyr Met Tyr Gly Leu Thr Pro Ala Leu Thr Lys Tyr Val Val Arg Trp 
705                 710                 715                 720 


Glu Trp Val Val Leu Leu Phe Leu Leu Leu Ala Asp Ala Arg Val Cys 
                725                 730                 735     


Ala Cys Leu Trp Met Leu Ile Leu Leu Gly Gln Ala Glu Ala 
            740                 745                 750 


<210>  34
<211>  750
<212>  PRT
<213>  Hepatitis C virus

<400>  34

Met Ser Thr Asn Pro Lys Pro Gln Arg Lys Thr Lys Arg Asn Thr Ser 
1               5                   10                  15      


Arg Arg Pro Gln Asp Val Lys Phe Pro Gly Gly Gly Gln Ile Val Gly 
            20                  25                  30          


Gly Val Tyr Leu Leu Pro Arg Arg Gly Pro Arg Leu Gly Val Arg Ala 
        35                  40                  45              


Thr Arg Lys Thr Ser Glu Arg Ser Gln Pro Arg Gly Arg Arg Gln Pro 
    50                  55                  60                  


Ile Pro Lys Asp Arg Arg Ser Thr Gly Lys Ser Trp Gly Lys Pro Gly 
65                  70                  75                  80  


Tyr Pro Trp Pro Leu Tyr Gly Asn Glu Gly Leu Gly Trp Ala Gly Trp 
                85                  90                  95      


Leu Leu Ser Pro Arg Gly Ser Arg Pro Ser Trp Gly Pro Thr Asp Pro 
            100                 105                 110         


Arg His Arg Ser Arg Asn Val Gly Lys Val Ile Asp Thr Leu Thr Cys 
        115                 120                 125             


Gly Phe Ala Asp Leu Met Gly Tyr Ile Pro Val Val Gly Ala Pro Leu 
    130                 135                 140                 


Gly Gly Val Ala Arg Ala Leu Ala His Gly Val Arg Val Leu Glu Asp 
145                 150                 155                 160 


Gly Val Asn Tyr Ala Thr Gly Asn Leu Pro Gly Cys Ser Phe Ser Ile 
                165                 170                 175     


Phe Leu Leu Ala Leu Leu Ser Cys Ile Thr Val Pro Val Ser Ala Val 
            180                 185                 190         


Gln Val Lys Asn Ile Ser Asp Ser Tyr Met Val Thr Asn Asp Cys Ser 
        195                 200                 205             


Asn Asp Ser Ile Thr Trp Gln Leu Gln Ala Ala Val Leu His Val Pro 
    210                 215                 220                 


Gly Cys Val Pro Cys Glu Lys Met Gly Asn Ile Ser Arg Cys Trp Ile 
225                 230                 235                 240 


Pro Val Ser Pro Asn Val Ala Val Gln Arg Pro Gly Ala Leu Thr Gln 
                245                 250                 255     


Gly Leu Arg Ala His Ile Asp Met Val Val Met Ser Ala Thr Leu Cys 
            260                 265                 270         


Ser Ala Leu Tyr Val Gly Asp Leu Cys Gly Gly Val Met Leu Ala Ala 
        275                 280                 285             


Gln Met Phe Ile Val Ser Pro Gln His His His Phe Val Gln Glu Cys 
    290                 295                 300                 


Asn Cys Ser Ile Tyr Pro Gly Ala Ile Thr Gly His Arg Met Ala Trp 
305                 310                 315                 320 


Asp Met Met Met Asn Trp Ser Pro Thr Ala Thr Met Ile Leu Ala Tyr 
                325                 330                 335     


Ala Met Arg Val Pro Glu Val Ile Ile Asp Ile Ile Ser Gly Ala His 
            340                 345                 350         


Trp Gly Val Met Phe Gly Leu Ala Tyr Phe Ser Met Gln Gly Ala Trp 
        355                 360                 365             


Ala Lys Val Val Val Ile Leu Leu Leu Thr Ala Gly Val Asp Ala His 
    370                 375                 380                 


Thr Arg Ser Ile Ala Gly Ser Val Ala His Ala Thr Ser Gly Leu Ala 
385                 390                 395                 400 


Gly Leu Phe Thr Ser Gly Ala Lys Gln Asn Ile Gln Leu Ile Asn Thr 
                405                 410                 415     


Asn Gly Ser Trp His Ile Asn Arg Thr Ala Leu Asn Cys Asn Asp Ser 
            420                 425                 430         


Leu Asn Thr Gly Phe Ile Ala Ser Leu Phe Tyr Thr Tyr Arg Phe Asn 
        435                 440                 445             


Ser Ser Gly Cys Pro Glu Arg Leu Ser Ala Cys Arg Gly Ile Gln Ala 
    450                 455                 460                 


Phe Arg Ile Gly Trp Gly Thr Leu Arg Tyr Glu Asp Asn Val Thr Asn 
465                 470                 475                 480 


Pro Glu Asp Met Arg Pro Tyr Cys Trp His Tyr Pro Pro Lys Gln Cys 
                485                 490                 495     


Gly Ile Val Ser Ala Arg Ser Val Cys Gly Pro Val Tyr Cys Phe Thr 
            500                 505                 510         


Pro Ser Pro Val Val Val Gly Thr Thr Asp Arg Leu Gly Val Pro Thr 
        515                 520                 525             


Tyr Thr Trp Gly Glu Asn Glu Thr Asp Val Phe Ile Leu Asn Ser Thr 
    530                 535                 540                 


Arg Pro Pro Gly Gly Ser Trp Phe Gly Cys Thr Trp Met Asn Ser Thr 
545                 550                 555                 560 


Gly Phe Thr Lys Thr Cys Gly Ala Pro Pro Cys Arg Ile Arg Ala Asp 
                565                 570                 575     


Phe Asn Ala Ser Met Asp Leu Leu Cys Pro Thr Asp Cys Phe Arg Lys 
            580                 585                 590         


His Pro Asp Ala Thr Tyr Ile Lys Cys Gly Ser Gly Pro Trp Leu Thr 
        595                 600                 605             


Pro Arg Cys Leu Val Asp Tyr Pro Tyr Arg Leu Trp His Tyr Pro Cys 
    610                 615                 620                 


Thr Ile Asn Tyr Thr Ile Phe Lys Ile Arg Met Tyr Val Gly Gly Val 
625                 630                 635                 640 


Glu His Arg Leu Thr Ala Ala Cys Asn Phe Thr Arg Gly Asp Pro Cys 
                645                 650                 655     


Asn Leu Glu Asp Arg Asp Arg Ser Gln Leu Ser Pro Leu Leu His Ser 
            660                 665                 670         


Thr Thr Glu Trp Ala Ile Leu Pro Cys Ser Tyr Ser Asp Leu Pro Ala 
        675                 680                 685             


Leu Ser Thr Gly Leu Leu His Leu His Gln Asn Ile Val Asp Val Gln 
    690                 695                 700                 


Tyr Met Tyr Gly Leu Ser Pro Ala Leu Thr Lys Tyr Ile Val Arg Trp 
705                 710                 715                 720 


Glu Trp Val Val Leu Leu Phe Leu Leu Leu Ala Asp Ala Arg Val Cys 
                725                 730                 735     


Ala Cys Leu Trp Met Leu Ile Leu Leu Gly Gln Ala Glu Ala 
            740                 745                 750 


<210>  35
<211>  751
<212>  PRT
<213>  Hepatitis C virus

<400>  35

Met Ser Thr Asn Pro Lys Pro Gln Arg Lys Thr Gln Arg Asn Thr Asn 
1               5                   10                  15      


Arg Arg Pro Gln Asp Val Lys Phe Pro Gly Gly Gly Gln Ile Val Gly 
            20                  25                  30          


Gly Val Tyr Leu Leu Pro Arg Arg Gly Pro Arg Leu Gly Val Arg Thr 
        35                  40                  45              


Ala Arg Lys Thr Ser Glu Arg Ser Gln Pro Arg Gly Arg Arg Gln Pro 
    50                  55                  60                  


Ile Pro Lys Asp Arg Arg Ser Thr Gly Lys Ser Trp Gly Arg Pro Gly 
65                  70                  75                  80  


Tyr Pro Trp Pro Leu Tyr Gly Asn Glu Gly Leu Gly Trp Ala Gly Trp 
                85                  90                  95      


Leu Leu Ser Pro Arg Gly Ser Arg Pro Ser Trp Gly Pro Thr Asp Pro 
            100                 105                 110         


Arg His Arg Ser Arg Asn Val Gly Lys Val Ile Asp Thr Leu Thr Cys 
        115                 120                 125             


Gly Phe Ala Asp Leu Met Gly Tyr Ile Pro Val Val Gly Ala Pro Leu 
    130                 135                 140                 


Gly Gly Val Ala Arg Ala Leu Ala His Gly Val Arg Val Leu Glu Asp 
145                 150                 155                 160 


Gly Val Asn Tyr Ala Thr Gly Asn Leu Pro Gly Cys Ser Phe Ser Ile 
                165                 170                 175     


Phe Leu Leu Ala Leu Leu Ser Cys Ile Thr Ile Pro Ala Ser Ala Val 
            180                 185                 190         


Glu Val Lys Asn Thr Ser Thr Gly Tyr Met Val Thr Asn Asp Cys Ala 
        195                 200                 205             


Asn Ser Ser Ile Thr Trp Gln Leu His Ala Ala Val Leu His Val Pro 
    210                 215                 220                 


Gly Cys Val Pro Cys Glu Arg Val Asp Asn Asn Thr Ser Arg Cys Trp 
225                 230                 235                 240 


Ile Pro Val Ser Pro Asn Ile Ala Val Gln Arg Pro Gly Ala Leu Thr 
                245                 250                 255     


Gln Gly Leu Arg Ser His Ile Asp Ile Val Val Met Ser Ala Thr Leu 
            260                 265                 270         


Cys Ser Ala Leu Tyr Val Gly Asp Leu Cys Gly Gly Val Met Leu Ala 
        275                 280                 285             


Ala Gln Met Phe Val Val Ser Pro Glu His His Trp Phe Val Gln Glu 
    290                 295                 300                 


Cys Asn Cys Ser Ile Tyr Pro Gly Thr Ile Thr Gly His Arg Met Ala 
305                 310                 315                 320 


Trp Asp Met Met Met Asn Trp Ser Pro Thr Ala Thr Met Ile Leu Ala 
                325                 330                 335     


Tyr Ala Met Arg Val Pro Glu Val Ile Ile Asp Ile Ile Gly Gly Ala 
            340                 345                 350         


His Trp Gly Val Met Phe Gly Leu Ala Tyr Phe Ser Met Gln Gly Ala 
        355                 360                 365             


Trp Ala Lys Val Val Val Ile Leu Leu Leu Ala Ala Gly Val Asp Ala 
    370                 375                 380                 


Tyr Thr His Thr Val Gly Gly Ala Ala Ala Ser Thr Ala Asn Ser Ile 
385                 390                 395                 400 


Ala Gly Leu Leu Ser Arg Gly Pro Arg Gln Asn Leu Gln Leu Ile Asn 
                405                 410                 415     


Ser Asn Gly Ser Trp His Ile Asn Arg Thr Ala Leu Asn Cys His Asp 
            420                 425                 430         


Ser Leu Gln Thr Gly Phe Ile Thr Ala Leu Phe Tyr Ala Arg His Phe 
        435                 440                 445             


Asn Ser Ser Gly Cys Pro Glu Arg Leu Ala Ala Cys Arg Asn Ile Glu 
    450                 455                 460                 


Ala Phe Arg Val Gly Trp Gly Ala Leu Gln Tyr Glu Asp Asn Val Thr 
465                 470                 475                 480 


Asn Pro Glu Asp Met Arg Pro Tyr Cys Trp His Tyr Pro Pro Lys Gln 
                485                 490                 495     


Cys Gly Ile Val Pro Ala Arg Ser Val Cys Gly Pro Val Tyr Cys Phe 
            500                 505                 510         


Thr Pro Ser Pro Val Val Val Gly Thr Thr Asp Lys Leu Gly Val Pro 
        515                 520                 525             


Thr Tyr Thr Trp Gly Glu Asn Glu Thr Asp Val Phe Leu Leu Asn Ser 
    530                 535                 540                 


Thr Arg Pro Pro Gln Gly Pro Trp Phe Gly Cys Thr Trp Met Asn Ser 
545                 550                 555                 560 


Thr Gly Phe Thr Lys Thr Cys Gly Ala Pro Pro Cys Arg Thr Arg Ala 
                565                 570                 575     


Asp Phe Asn Ala Ser Thr Asp Leu Leu Cys Pro Thr Asp Cys Phe Arg 
            580                 585                 590         


Lys His Pro Asp Ala Thr Tyr Asn Lys Cys Gly Ser Gly Pro Trp Leu 
        595                 600                 605             


Thr Pro Arg Cys Leu Ile Asp Tyr Pro Tyr Arg Leu Trp His Tyr Pro 
    610                 615                 620                 


Cys Thr Val Asn Tyr Thr Thr Phe Lys Ile Arg Met Tyr Val Gly Gly 
625                 630                 635                 640 


Val Glu His Arg Leu Met Ala Ala Cys Asn Phe Thr Arg Gly Asp Ser 
                645                 650                 655     


Cys Asp Leu Ser Gln Arg Asp Arg Gly Gln Leu Ser Pro Leu Leu His 
            660                 665                 670         


Ser Thr Thr Glu Trp Ala Ile Leu Pro Cys Ser Phe Ser Asp Leu Pro 
        675                 680                 685             


Ala Leu Ser Thr Gly Leu Leu His Leu His Gln Asn Ile Val Asp Val 
    690                 695                 700                 


Gln Tyr Met Tyr Gly Leu Ser Pro Ala Leu Thr Lys Tyr Ile Val Arg 
705                 710                 715                 720 


Trp Glu Trp Val Val Leu Leu Phe Leu Leu Leu Ala Asp Ala Arg Val 
                725                 730                 735     


Cys Ala Cys Ile Trp Met Leu Ile Leu Leu Gly Gln Ala Glu Ala 
            740                 745                 750     


<210>  36
<211>  750
<212>  PRT
<213>  Hepatitis C virus

<400>  36

Met Ser Thr Asn Pro Lys Pro Gln Arg Lys Thr Lys Arg Asn Thr Asn 
1               5                   10                  15      


Arg Arg Pro Gln Asp Val Lys Phe Pro Gly Gly Gly Gln Ile Val Gly 
            20                  25                  30          


Gly Val Tyr Leu Leu Pro Arg Arg Gly Pro Arg Leu Gly Val Arg Ala 
        35                  40                  45              


Thr Arg Lys Thr Ser Glu Arg Ser Gln Pro Arg Gly Arg Arg Gln Pro 
    50                  55                  60                  


Ile Pro Lys Asp Arg Arg Ser Thr Gly Lys Ser Trp Gly Lys Pro Gly 
65                  70                  75                  80  


Tyr Pro Trp Pro Leu Tyr Gly Asn Glu Gly Leu Gly Trp Ala Gly Trp 
                85                  90                  95      


Leu Leu Ser Pro Arg Gly Ser Arg Pro Ser Trp Gly Pro Asn Asp Pro 
            100                 105                 110         


Arg His Arg Ser Arg Asn Val Gly Lys Val Ile Asp Thr Leu Thr Cys 
        115                 120                 125             


Gly Phe Ala Asp Leu Met Gly Tyr Ile Pro Val Val Gly Ala Pro Leu 
    130                 135                 140                 


Gly Gly Val Ala Arg Ala Leu Ala His Gly Val Arg Val Leu Glu Asp 
145                 150                 155                 160 


Gly Val Asn Phe Ala Thr Gly Asn Leu Pro Gly Cys Ser Phe Ser Ile 
                165                 170                 175     


Phe Leu Leu Ala Leu Leu Ser Cys Ile Thr Thr Pro Val Ser Ala Ala 
            180                 185                 190         


Glu Val Lys Asn Ile Ser Thr Gly Tyr Met Val Thr Asn Asp Cys Thr 
        195                 200                 205             


Asn Asp Ser Ile Thr Trp Gln Leu Gln Ala Ala Val Leu His Val Pro 
    210                 215                 220                 


Gly Cys Val Pro Cys Glu Lys Val Gly Asn Thr Ser Arg Cys Trp Ile 
225                 230                 235                 240 


Pro Val Ser Pro Asn Val Ala Val Gln Gln Pro Gly Ala Leu Thr Gln 
                245                 250                 255     


Gly Leu Arg Thr His Ile Asp Met Val Val Met Ser Ala Thr Leu Cys 
            260                 265                 270         


Ser Ala Leu Tyr Val Gly Asp Leu Cys Gly Gly Val Met Leu Ala Ala 
        275                 280                 285             


Gln Met Phe Ile Val Ser Pro Gln His His Trp Phe Val Gln Asp Cys 
    290                 295                 300                 


Asn Cys Ser Ile Tyr Pro Gly Thr Ile Thr Gly His Arg Met Ala Trp 
305                 310                 315                 320 


Asp Met Met Met Asn Trp Ser Pro Thr Ala Thr Met Ile Leu Ala Tyr 
                325                 330                 335     


Ala Met Arg Val Pro Glu Val Ile Ile Asp Ile Ile Gly Gly Ala His 
            340                 345                 350         


Trp Gly Val Met Phe Gly Leu Ala Tyr Phe Ser Met Gln Gly Ala Trp 
        355                 360                 365             


Ala Lys Val Val Val Ile Leu Leu Leu Ala Ala Gly Val Asp Ala Gln 
    370                 375                 380                 


Thr His Thr Val Gly Gly Ser Thr Ala His Asn Ala Arg Thr Leu Thr 
385                 390                 395                 400 


Gly Met Phe Ser Leu Gly Ala Arg Gln Lys Ile Gln Leu Ile Asn Thr 
                405                 410                 415     


Asn Gly Ser Trp His Ile Asn Arg Thr Ala Leu Asn Cys Asn Asp Ser 
            420                 425                 430         


Leu His Thr Gly Phe Leu Ala Ser Leu Phe Tyr Thr His Ser Phe Asn 
        435                 440                 445             


Ser Ser Gly Cys Pro Glu Arg Met Ser Ala Cys Arg Ser Ile Glu Ala 
    450                 455                 460                 


Phe Arg Val Gly Trp Gly Ala Leu Gln Tyr Glu Asp Asn Val Thr Asn 
465                 470                 475                 480 


Pro Glu Asp Met Arg Pro Tyr Cys Trp His Tyr Pro Pro Arg Gln Cys 
                485                 490                 495     


Gly Val Val Ser Ala Ser Ser Val Cys Gly Pro Val Tyr Cys Phe Thr 
            500                 505                 510         


Pro Ser Pro Val Val Val Gly Thr Thr Asp Arg Leu Gly Ala Pro Thr 
        515                 520                 525             


Tyr Thr Trp Gly Glu Asn Glu Thr Asp Val Phe Leu Leu Asn Ser Thr 
    530                 535                 540                 


Arg Pro Pro Gln Gly Ser Trp Phe Gly Cys Thr Trp Met Asn Ser Thr 
545                 550                 555                 560 


Gly Tyr Thr Lys Thr Cys Gly Ala Pro Pro Cys Arg Ile Arg Ala Asp 
                565                 570                 575     


Phe Asn Ala Ser Met Asp Leu Leu Cys Pro Thr Asp Cys Phe Arg Lys 
            580                 585                 590         


His Pro Asp Thr Thr Tyr Ile Lys Cys Gly Ser Gly Pro Trp Leu Thr 
        595                 600                 605             


Pro Arg Cys Leu Ile Asp Tyr Pro Tyr Arg Leu Trp His Tyr Pro Cys 
    610                 615                 620                 


Thr Val Asn Tyr Thr Ile Phe Lys Ile Arg Met Tyr Val Gly Gly Val 
625                 630                 635                 640 


Glu His Arg Leu Thr Ala Ala Cys Asn Phe Thr Arg Gly Asp Arg Cys 
                645                 650                 655     


Asn Leu Glu Asp Arg Asp Arg Ser Gln Leu Ser Pro Leu Leu His Ser 
            660                 665                 670         


Thr Thr Glu Trp Ala Ile Leu Pro Cys Thr Tyr Ser Asp Leu Pro Ala 
        675                 680                 685             


Leu Ser Thr Gly Leu Leu His Leu His Gln Asn Ile Val Asp Val Gln 
    690                 695                 700                 


Phe Met Tyr Gly Leu Ser Pro Ala Leu Thr Lys Tyr Ile Val Arg Trp 
705                 710                 715                 720 


Glu Trp Val Val Leu Leu Phe Leu Leu Leu Ala Asp Ala Arg Val Cys 
                725                 730                 735     


Ala Cys Leu Trp Met Leu Ile Leu Leu Gly Gln Ala Glu Ala 
            740                 745                 750 


<210>  37
<211>  750
<212>  PRT
<213>  Hepatitis C virus

<400>  37

Met Ser Thr Asn Pro Lys Pro Gln Arg Lys Thr Lys Arg Asn Thr Asn 
1               5                   10                  15      


Arg Arg Pro Gln Asp Val Lys Phe Pro Gly Gly Gly Gln Ile Val Gly 
            20                  25                  30          


Gly Val Tyr Leu Leu Pro Arg Arg Gly Pro Arg Leu Gly Val Arg Ala 
        35                  40                  45              


Thr Arg Lys Thr Ser Glu Arg Ser Gln Pro Arg Gly Arg Arg Gln Pro 
    50                  55                  60                  


Ile Pro Lys Asp Arg Arg Ser Thr Gly Lys Ser Trp Gly Lys Pro Gly 
65                  70                  75                  80  


Tyr Pro Trp Pro Leu Tyr Gly Asn Glu Gly Leu Gly Trp Ala Gly Trp 
                85                  90                  95      


Leu Leu Ser Pro Arg Gly Ser Arg Pro Ser Trp Gly Pro Asn Asp Pro 
            100                 105                 110         


Arg His Arg Ser Arg Asn Val Gly Lys Val Ile Asp Thr Leu Thr Cys 
        115                 120                 125             


Gly Phe Ala Asp Leu Met Gly Tyr Ile Pro Val Val Gly Ala Pro Leu 
    130                 135                 140                 


Gly Gly Val Ala Arg Ala Leu Ala His Gly Val Arg Val Leu Glu Asp 
145                 150                 155                 160 


Gly Val Asn Phe Ala Thr Gly Asn Leu Pro Gly Cys Ser Phe Ser Ile 
                165                 170                 175     


Phe Leu Leu Ala Leu Leu Ser Cys Ile Thr Thr Pro Val Ser Ala Ala 
            180                 185                 190         


Glu Val Lys Asn Ile Ser Thr Gly Tyr Met Val Thr Asn Asp Cys Thr 
        195                 200                 205             


Asn Asp Ser Ile Thr Trp Gln Leu Gln Ala Ala Val Leu His Val Pro 
    210                 215                 220                 


Gly Cys Val Pro Cys Glu Lys Val Gly Asn Ala Ser Gln Cys Trp Ile 
225                 230                 235                 240 


Pro Val Ser Pro Asn Val Ala Val Gln Arg Pro Gly Ala Leu Thr Gln 
                245                 250                 255     


Gly Leu Arg Thr His Ile Asp Met Val Val Met Ser Ala Thr Leu Cys 
            260                 265                 270         


Ser Ala Leu Tyr Val Gly Asp Leu Cys Gly Gly Val Met Leu Ala Ala 
        275                 280                 285             


Gln Met Phe Ile Val Ser Pro Gln His His Trp Phe Val Gln Asp Cys 
    290                 295                 300                 


Asn Cys Ser Ile Tyr Pro Gly Thr Ile Thr Gly His Arg Met Ala Trp 
305                 310                 315                 320 


Asp Met Met Met Asn Trp Ser Pro Thr Ala Thr Met Ile Leu Ala Tyr 
                325                 330                 335     


Ala Met Arg Val Pro Glu Val Ile Ile Asp Ile Ile Ser Gly Ala His 
            340                 345                 350         


Trp Gly Val Met Phe Gly Leu Ala Tyr Phe Ser Met Gln Gly Ala Trp 
        355                 360                 365             


Ala Lys Val Val Val Ile Leu Leu Leu Ala Ala Gly Val Asp Ala Arg 
    370                 375                 380                 


Thr His Thr Val Gly Gly Ser Ala Ala Gln Thr Thr Gly Arg Leu Thr 
385                 390                 395                 400 


Ser Leu Phe Asp Met Gly Pro Arg Gln Lys Ile Gln Leu Val Asn Thr 
                405                 410                 415     


Asn Gly Ser Trp His Ile Asn Arg Thr Ala Leu Asn Cys Asn Asp Ser 
            420                 425                 430         


Leu His Thr Gly Phe Ile Ala Ser Leu Phe Tyr Thr His Ser Phe Asn 
        435                 440                 445             


Ser Ser Gly Cys Pro Glu Arg Met Ser Ala Cys Arg Ser Ile Glu Ala 
    450                 455                 460                 


Phe Arg Val Gly Trp Gly Ala Leu Gln Tyr Glu Asp Asn Val Thr Asn 
465                 470                 475                 480 


Pro Glu Asp Met Arg Pro Tyr Cys Trp His Tyr Pro Pro Arg Gln Cys 
                485                 490                 495     


Gly Val Val Ser Ala Lys Thr Val Cys Gly Pro Val Tyr Cys Phe Thr 
            500                 505                 510         


Pro Ser Pro Val Val Val Gly Thr Thr Asp Arg Leu Gly Ala Pro Thr 
        515                 520                 525             


Tyr Thr Trp Gly Glu Asn Glu Thr Asp Val Phe Leu Leu Asn Ser Thr 
    530                 535                 540                 


Arg Pro Pro Leu Gly Ser Trp Phe Gly Cys Thr Trp Met Asn Ser Ser 
545                 550                 555                 560 


Gly Tyr Thr Lys Thr Cys Gly Ala Pro Pro Cys Arg Thr Arg Ala Asp 
                565                 570                 575     


Phe Asn Ala Ser Thr Asp Leu Leu Cys Pro Thr Asp Cys Phe Arg Lys 
            580                 585                 590         


His Pro Asp Thr Thr Tyr Leu Lys Cys Gly Ser Gly Pro Trp Leu Thr 
        595                 600                 605             


Pro Arg Cys Leu Ile Asp Tyr Pro Tyr Arg Leu Trp His Tyr Pro Cys 
    610                 615                 620                 


Thr Val Asn Tyr Thr Ile Phe Lys Ile Arg Met Tyr Val Gly Gly Val 
625                 630                 635                 640 


Glu His Arg Leu Thr Ala Ala Cys Asn Phe Thr Arg Gly Asp Arg Cys 
                645                 650                 655     


Asn Leu Glu Asp Arg Asp Arg Ser Gln Leu Ser Pro Leu Leu His Ser 
            660                 665                 670         


Thr Thr Glu Trp Ala Ile Leu Pro Cys Ser Tyr Ser Asp Leu Pro Ala 
        675                 680                 685             


Leu Ser Thr Gly Leu Leu His Leu His Gln Asn Ile Val Asp Val Gln 
    690                 695                 700                 


Phe Met Tyr Gly Leu Ser Pro Ala Leu Thr Lys Tyr Ile Val Arg Trp 
705                 710                 715                 720 


Glu Trp Val Ile Leu Leu Phe Leu Leu Leu Ala Asp Ala Arg Val Cys 
                725                 730                 735     


Ala Cys Leu Trp Met Leu Ile Leu Leu Gly Gln Ala Glu Ala 
            740                 745                 750 


<210>  38
<211>  750
<212>  PRT
<213>  Hepatitis C virus

<400>  38

Met Ser Thr Asn Pro Lys Pro Gln Arg Lys Thr Lys Arg Asn Thr Asn 
1               5                   10                  15      


Arg Arg Pro Gln Asp Val Lys Phe Pro Gly Gly Gly Gln Ile Val Gly 
            20                  25                  30          


Gly Val Tyr Leu Leu Pro Arg Arg Gly Pro Arg Leu Gly Val Arg Ala 
        35                  40                  45              


Thr Arg Lys Thr Ser Glu Arg Ser Gln Pro Arg Gly Arg Arg Gln Pro 
    50                  55                  60                  


Ile Pro Lys Asp Arg Arg Ser Thr Gly Lys Ser Trp Gly Lys Pro Gly 
65                  70                  75                  80  


Tyr Pro Trp Pro Leu Tyr Gly Asn Glu Gly Cys Gly Trp Ala Gly Trp 
                85                  90                  95      


Leu Leu Ser Pro Arg Gly Ser Arg Pro Thr Trp Gly Pro Thr Asp Pro 
            100                 105                 110         


Arg His Arg Ser Arg Asn Leu Gly Arg Val Ile Asp Thr Ile Thr Cys 
        115                 120                 125             


Gly Phe Ala Asp Leu Met Gly Tyr Ile Pro Val Val Gly Ala Pro Val 
    130                 135                 140                 


Gly Gly Val Ala Arg Ala Leu Ala His Gly Val Arg Val Leu Glu Asp 
145                 150                 155                 160 


Gly Ile Asn Tyr Ala Thr Gly Asn Leu Pro Gly Cys Ser Phe Ser Ile 
                165                 170                 175     


Phe Leu Leu Ala Leu Leu Ser Cys Val Thr Val Pro Val Ser Ala Val 
            180                 185                 190         


Glu Val Arg Asn Ile Ser Ser Ser Tyr Tyr Ala Thr Asn Asp Cys Ser 
        195                 200                 205             


Asn Asn Ser Ile Thr Trp Gln Leu Thr Asp Ala Val Leu His Leu Pro 
    210                 215                 220                 


Gly Cys Val Pro Cys Glu Asn Asp Asn Gly Thr Leu His Cys Trp Ile 
225                 230                 235                 240 


Gln Val Thr Pro Asn Val Ala Val Lys His Arg Gly Ala Leu Thr Arg 
                245                 250                 255     


Ser Leu Arg Thr His Val Asp Met Ile Val Met Ala Ala Thr Ala Cys 
            260                 265                 270         


Ser Ala Leu Tyr Val Gly Asp Val Cys Gly Ala Val Met Ile Leu Ser 
        275                 280                 285             


Gln Ala Phe Met Val Ser Pro Gln Arg His Asn Phe Thr Gln Glu Cys 
    290                 295                 300                 


Asn Cys Ser Ile Tyr Gln Gly His Ile Thr Gly His Arg Met Ala Trp 
305                 310                 315                 320 


Asp Met Met Leu Ser Trp Ser Pro Thr Leu Thr Met Ile Leu Ala Tyr 
                325                 330                 335     


Ala Ala Arg Val Pro Glu Leu Val Leu Glu Ile Ile Phe Gly Gly His 
            340                 345                 350         


Trp Gly Val Val Phe Gly Leu Ala Tyr Phe Ser Met Gln Gly Ala Trp 
        355                 360                 365             


Ala Lys Val Ile Ala Ile Leu Leu Leu Val Ala Gly Val Asp Ala Thr 
    370                 375                 380                 


Thr Tyr Ser Ser Gly Gln Glu Ala Gly Arg Thr Val Ala Gly Phe Ala 
385                 390                 395                 400 


Gly Leu Phe Thr Thr Gly Ala Lys Gln Asn Leu Tyr Leu Ile Asn Thr 
                405                 410                 415     


Asn Gly Ser Trp His Ile Asn Arg Thr Ala Leu Asn Cys Asn Asp Ser 
            420                 425                 430         


Leu Gln Thr Gly Phe Leu Ala Ser Leu Phe Tyr Thr His Lys Phe Asn 
        435                 440                 445             


Ser Ser Gly Cys Pro Glu Arg Leu Ser Ser Cys Arg Gly Leu Asp Asp 
    450                 455                 460                 


Phe Arg Ile Gly Trp Gly Thr Leu Glu Tyr Glu Thr Asn Val Thr Asn 
465                 470                 475                 480 


Asp Gly Asp Met Arg Pro Tyr Cys Trp His Tyr Pro Pro Arg Pro Cys 
                485                 490                 495     


Gly Ile Val Pro Ala Arg Thr Val Cys Gly Pro Val Tyr Cys Phe Thr 
            500                 505                 510         


Pro Ser Pro Val Val Val Gly Thr Thr Asp Lys Gln Gly Val Pro Thr 
        515                 520                 525             


Tyr Thr Trp Gly Glu Asn Glu Thr Asp Val Phe Leu Leu Asn Ser Thr 
    530                 535                 540                 


Arg Pro Pro Arg Gly Ala Trp Phe Gly Cys Thr Trp Met Asn Gly Thr 
545                 550                 555                 560 


Gly Phe Thr Lys Thr Cys Gly Ala Pro Pro Cys Arg Ile Arg Lys Asp 
                565                 570                 575     


Tyr Asn Ser Thr Ile Asp Leu Leu Cys Pro Thr Asp Cys Phe Arg Lys 
            580                 585                 590         


His Pro Asp Ala Thr Tyr Leu Lys Cys Gly Ala Gly Pro Trp Leu Thr 
        595                 600                 605             


Pro Arg Cys Leu Val Asp Tyr Pro Tyr Arg Leu Trp His Tyr Pro Cys 
    610                 615                 620                 


Thr Val Asn Phe Thr Ile Phe Lys Ala Arg Met Tyr Val Gly Gly Val 
625                 630                 635                 640 


Glu His Arg Phe Ser Ala Ala Cys Asn Phe Thr Arg Gly Asp Arg Cys 
                645                 650                 655     


Arg Leu Glu Asp Arg Asp Arg Gly Gln Gln Ser Pro Leu Leu His Ser 
            660                 665                 670         


Thr Thr Glu Trp Ala Val Leu Pro Cys Ser Phe Ser Asp Leu Pro Ala 
        675                 680                 685             


Leu Ser Thr Gly Leu Leu His Leu His Gln Asn Ile Val Asp Val Gln 
    690                 695                 700                 


Tyr Leu Tyr Gly Leu Ser Pro Ala Leu Thr Arg Tyr Ile Val Lys Trp 
705                 710                 715                 720 


Glu Trp Val Ile Leu Leu Phe Leu Leu Leu Ala Asp Ala Arg Ile Cys 
                725                 730                 735     


Ala Cys Leu Trp Met Leu Ile Ile Leu Gly Gln Ala Glu Ala 
            740                 745                 750 


<210>  39
<211>  750
<212>  PRT
<213>  Hepatitis C virus

<400>  39

Met Ser Thr Asn Pro Lys Pro Gln Arg Lys Thr Lys Arg Asn Thr Asn 
1               5                   10                  15      


Arg Arg Pro Gln Asp Val Lys Phe Pro Gly Gly Gly Gln Ile Val Gly 
            20                  25                  30          


Gly Val Tyr Leu Leu Pro Arg Arg Gly Pro Arg Leu Gly Val Arg Ala 
        35                  40                  45              


Thr Arg Lys Thr Ser Glu Arg Ser Gln Pro Arg Gly Arg Arg Gln Pro 
    50                  55                  60                  


Ile Pro Lys Asp Arg Arg Ser Thr Gly Lys Ser Trp Gly Lys Pro Gly 
65                  70                  75                  80  


Tyr Pro Trp Pro Leu Tyr Gly Asn Glu Gly Cys Gly Trp Ala Gly Trp 
                85                  90                  95      


Leu Leu Ser Pro Arg Gly Ser Arg Pro His Trp Gly Pro Thr Asp Pro 
            100                 105                 110         


Arg His Arg Ser Arg Asn Leu Gly Lys Val Ile Asp Thr Ile Thr Cys 
        115                 120                 125             


Gly Phe Ala Asp Leu Met Gly Tyr Ile Pro Val Ile Gly Ala Pro Val 
    130                 135                 140                 


Gly Gly Val Ala Arg Ala Leu Ala His Gly Val Arg Val Leu Glu Asp 
145                 150                 155                 160 


Gly Val Asn Tyr Ala Thr Gly Asn Leu Pro Gly Cys Ser Phe Ser Ile 
                165                 170                 175     


Phe Leu Leu Ala Leu Leu Ser Cys Val Thr Val Pro Val Ser Ala Val 
            180                 185                 190         


Glu Val Arg Asn Ile Ser Ser Ser Tyr Tyr Ala Thr Asn Asp Cys Ser 
        195                 200                 205             


Asn Asn Ser Ile Thr Trp Gln Leu Glu Asn Ala Val Leu His Leu Pro 
    210                 215                 220                 


Gly Cys Val Pro Cys Glu Asn Asp Asn Gly Thr Leu Arg Cys Trp Thr 
225                 230                 235                 240 


Gln Val Thr Pro Asn Val Ala Val Lys His Arg Gly Ala Leu Thr Gln 
                245                 250                 255     


Asn Leu Arg Thr His Val Asp Val Ile Val Val Ala Ala Thr Val Cys 
            260                 265                 270         


Ser Ala Leu Tyr Val Gly Asp Val Cys Gly Ala Val Met Ile Ala Ser 
        275                 280                 285             


Gln Ala Leu Ile Val Ser Pro Ala Arg His Asn Phe Thr Gln Glu Cys 
    290                 295                 300                 


Asn Cys Ser Ile Tyr Gln Gly Arg Ile Thr Gly His His Met Ala Trp 
305                 310                 315                 320 


Asp Met Met Leu Asn Trp Ser Pro Thr Ile Thr Met Ile Leu Ala Tyr 
                325                 330                 335     


Ala Ala Arg Ile Pro Glu Leu Val Leu Glu Val Ile Phe Gly Gly His 
            340                 345                 350         


Trp Gly Val Met Phe Gly Leu Ala Tyr Phe Ser Met Gln Gly Ala Trp 
        355                 360                 365             


Ala Lys Val Ile Val Ile Leu Leu Leu Val Ala Gly Val Asp Ala Arg 
    370                 375                 380                 


His His Thr Thr Gly Leu Gln Ala Gly Lys Thr Leu Ala Arg Val Thr 
385                 390                 395                 400 


Ser Leu Phe Ser Ile Gly Ala Lys Gln Asn Ile Gln Leu Ile Asn Thr 
                405                 410                 415     


Asn Gly Ser Trp His Ile Asn Arg Thr Ala Leu Asn Cys Asn Asp Ser 
            420                 425                 430         


Leu Gln Thr Gly Phe Ile Ala Ser Leu Phe Tyr Val Asn Asn Ile Asn 
        435                 440                 445             


Ser Ser Gly Cys Pro Glu Arg Met Ser Ser Cys Arg Glu Leu Asp Asp 
    450                 455                 460                 


Phe Arg Ile Gly Trp Gly Thr Leu Glu Tyr Glu Thr Asn Val Thr Asn 
465                 470                 475                 480 


Asp Glu Asp Met Arg Pro Tyr Cys Trp His Tyr Pro Pro Lys Pro Cys 
                485                 490                 495     


Gly Ile Val Pro Ala Arg Thr Val Cys Gly Pro Val Tyr Cys Phe Thr 
            500                 505                 510         


Pro Ser Pro Ile Val Val Gly Thr Thr Asp Lys Gln Gly Val Pro Thr 
        515                 520                 525             


Tyr Ser Trp Gly Glu Asn Glu Thr Asp Val Phe Leu Leu Asn Ser Thr 
    530                 535                 540                 


Arg Pro Pro Arg Gly Ser Trp Phe Gly Cys Thr Trp Met Asn Gly Thr 
545                 550                 555                 560 


Gly Phe Thr Lys Thr Cys Gly Ala Pro Pro Cys Arg Ile Arg Arg Asp 
                565                 570                 575     


Tyr Asn Ser Thr Leu Asp Leu Leu Cys Pro Thr Asp Cys Phe Arg Lys 
            580                 585                 590         


His Pro Asp Thr Thr Tyr Leu Lys Cys Gly Ser Gly Pro Trp Leu Thr 
        595                 600                 605             


Pro Lys Cys Leu Val Glu Tyr Pro Tyr Arg Leu Trp His Tyr Pro Cys 
    610                 615                 620                 


Thr Val Asn Phe Thr Ile Phe Lys Val Arg Met Tyr Val Gly Ala Val 
625                 630                 635                 640 


Glu His Arg Phe Ser Ala Ala Cys Asn Phe Thr Arg Gly Asp Arg Cys 
                645                 650                 655     


Arg Leu Glu Asp Arg Asp Arg Gly Gln Gln Ser Pro Leu Leu His Ser 
            660                 665                 670         


Thr Thr Glu Trp Ala Val Leu Pro Cys Ser Phe Ser Asp Leu Pro Ala 
        675                 680                 685             


Leu Ser Thr Gly Leu Leu His Leu His Gln Asn Ile Val Asp Val Gln 
    690                 695                 700                 


Tyr Leu Tyr Gly Leu Ser Pro Ala Ile Thr Arg Tyr Ile Val Lys Trp 
705                 710                 715                 720 


Glu Trp Val Val Leu Leu Phe Leu Leu Leu Ala Asp Ala Arg Val Cys 
                725                 730                 735     


Ala Cys Leu Trp Met Leu Ile Ile Leu Gly Gln Ala Glu Ala 
            740                 745                 750 


<210>  40
<211>  750
<212>  PRT
<213>  Hepatitis C virus

<400>  40

Met Ser Thr Asn Pro Lys Pro Gln Arg Lys Thr Lys Arg Asn Thr Asn 
1               5                   10                  15      


Arg Arg Pro Gln Asp Val Lys Phe Pro Gly Gly Gly Gln Ile Val Gly 
            20                  25                  30          


Gly Val Tyr Leu Leu Pro Arg Arg Gly Pro Arg Leu Gly Val Arg Ala 
        35                  40                  45              


Thr Arg Lys Thr Ser Glu Arg Ser Gln Pro Arg Gly Arg Arg Gln Pro 
    50                  55                  60                  


Ile Pro Lys Asp Arg Arg Ser Thr Gly Lys Ser Trp Gly Lys Pro Gly 
65                  70                  75                  80  


Tyr Pro Trp Pro Leu Tyr Gly Asn Glu Gly Cys Gly Trp Ala Gly Trp 
                85                  90                  95      


Leu Leu Ser Pro Arg Gly Ser Arg Pro Thr Trp Gly Pro Thr Asp Pro 
            100                 105                 110         


Arg His Arg Ser Arg Asn Leu Gly Arg Val Ile Asp Thr Ile Thr Cys 
        115                 120                 125             


Gly Phe Ala Asp Leu Met Gly Tyr Ile Pro Val Val Gly Ala Pro Val 
    130                 135                 140                 


Gly Gly Val Ala Arg Ala Leu Ala His Gly Val Arg Val Leu Glu Asp 
145                 150                 155                 160 


Gly Ile Asn Tyr Ala Thr Gly Asn Leu Pro Gly Cys Ser Phe Ser Ile 
                165                 170                 175     


Phe Leu Leu Ala Leu Leu Ser Cys Cys Thr Val Pro Val Ser Ala Val 
            180                 185                 190         


Glu Val Arg Asn Ile Ser Thr Ser Tyr Tyr Ala Thr Asn Asp Cys Ser 
        195                 200                 205             


Asn Thr Ser Ile Thr Trp Gln Leu Thr Asn Ala Val Leu His Leu Pro 
    210                 215                 220                 


Gly Cys Val Pro Cys Glu Asn Asp Asn Gly Thr Leu Arg Cys Trp Ile 
225                 230                 235                 240 


Gln Val Thr Pro Asn Val Ala Val Lys His Arg Gly Ala Leu Thr His 
                245                 250                 255     


Asn Leu Arg Thr His Val Asp Val Ile Val Met Ala Ala Thr Val Cys 
            260                 265                 270         


Ser Ala Leu Tyr Val Gly Asp Ile Cys Gly Ala Val Met Ile Val Ser 
        275                 280                 285             


Gln Ala Phe Ile Ile Ser Pro Glu Arg His Asn Phe Thr Gln Glu Cys 
    290                 295                 300                 


Asn Cys Ser Met Tyr Gln Gly His Ile Thr Gly His Arg Met Ala Trp 
305                 310                 315                 320 


Asp Met Met Leu Asn Trp Ser Pro Thr Leu Thr Met Ile Leu Ala Tyr 
                325                 330                 335     


Ala Ala Arg Val Pro Glu Leu Val Leu Glu Val Ile Phe Gly Gly His 
            340                 345                 350         


Trp Gly Val Val Phe Gly Leu Ala Tyr Phe Ser Met Gln Gly Ala Trp 
        355                 360                 365             


Ala Lys Val Ile Ala Ile Leu Leu Leu Val Ala Gly Val Asp Ala Asn 
    370                 375                 380                 


Thr Tyr Ser Ser Gly Val Thr Val Gly His Thr Thr Ser Thr Phe Ala 
385                 390                 395                 400 


Asn Ile Phe Ser Val Gly Pro Ser Gln Lys Ile Asn Leu Ile Asn Thr 
                405                 410                 415     


Asn Gly Ser Trp His Ile Asn Arg Thr Ala Leu Asn Cys Asn Asp Ser 
            420                 425                 430         


Leu Gln Thr Gly Phe Leu Ala Ser Leu Phe Tyr Val Arg Asn Phe Asn 
        435                 440                 445             


Ser Ser Gly Cys Arg Glu Arg Leu Ser Ser Cys Arg Arg Leu Asp Asp 
    450                 455                 460                 


Phe Arg Ile Gly Trp Gly Thr Leu Glu Tyr Glu Thr Asn Val Thr Asn 
465                 470                 475                 480 


Asp Glu Asp Met Arg Pro Tyr Cys Trp His Tyr Pro Pro Lys Pro Cys 
                485                 490                 495     


Gly Ile Val Ser Ala Arg Thr Val Cys Gly Pro Val Tyr Cys Phe Thr 
            500                 505                 510         


Pro Ser Pro Val Val Val Gly Thr Thr Asp Arg Gln Gly Val Pro Thr 
        515                 520                 525             


Tyr Ser Trp Gly Glu Asn Glu Thr Asp Val Phe Leu Leu Asn Ser Thr 
    530                 535                 540                 


Arg Pro Pro Arg Gly Ala Trp Phe Gly Cys Thr Trp Met Asn Gly Thr 
545                 550                 555                 560 


Gly Phe Thr Lys Thr Cys Gly Ala Pro Pro Cys Arg Ile Arg Arg Asp 
                565                 570                 575     


Tyr Asn Ser Thr Leu Asp Leu Leu Cys Pro Thr Asp Cys Phe Arg Lys 
            580                 585                 590         


His Pro Asp Thr Thr Tyr Leu Lys Cys Gly Ala Gly Pro Trp Leu Thr 
        595                 600                 605             


Pro Lys Cys Leu Val Asp Tyr Pro Tyr Arg Leu Trp His Tyr Pro Cys 
    610                 615                 620                 


Thr Val Asn Phe Thr Ile Phe Lys Val Arg Met Tyr Val Gly Gly Val 
625                 630                 635                 640 


Glu His Arg Leu Ser Ala Ala Cys Asn Phe Thr Arg Gly Asp Arg Cys 
                645                 650                 655     


Gly Leu Glu Asp Arg Asp Arg Gly Gln Gln Ser Pro Leu Leu His Ser 
            660                 665                 670         


Thr Thr Glu Trp Ala Val Leu Pro Cys Ser Phe Ser Asp Leu Pro Ala 
        675                 680                 685             


Leu Ser Thr Gly Leu Leu His Leu His Gln Asn Ile Val Asp Val Gln 
    690                 695                 700                 


Tyr Leu Tyr Gly Leu Ser Pro Ala Ile Thr Arg Tyr Ile Val Lys Trp 
705                 710                 715                 720 


Glu Trp Val Val Leu Leu Phe Leu Leu Leu Ala Asp Ala Arg Val Cys 
                725                 730                 735     


Ala Cys Leu Trp Met Leu Ile Ile Leu Gly Gln Ala Glu Ala 
            740                 745                 750 


<210>  41
<211>  750
<212>  PRT
<213>  Hepatitis C virus

<400>  41

Met Ser Thr Asn Pro Lys Pro Gln Arg Lys Thr Lys Arg Asn Thr Asn 
1               5                   10                  15      


Arg Arg Pro Gln Asp Val Lys Phe Pro Gly Gly Gly Gln Ile Val Gly 
            20                  25                  30          


Gly Val Tyr Leu Leu Pro Arg Arg Gly Pro Arg Leu Gly Val Arg Ala 
        35                  40                  45              


Thr Arg Lys Thr Ser Glu Arg Ser Gln Pro Arg Gly Arg Arg Gln Pro 
    50                  55                  60                  


Ile Pro Lys Asp Arg Arg Ser Thr Gly Lys Ser Trp Gly Lys Pro Gly 
65                  70                  75                  80  


Tyr Pro Trp Pro Leu Tyr Gly Asn Glu Gly Cys Gly Trp Ala Gly Trp 
                85                  90                  95      


Leu Leu Ser Pro Arg Gly Ser Arg Pro Thr Trp Gly Pro Ser Asp Pro 
            100                 105                 110         


Arg His Arg Ser Arg Asn Leu Gly Arg Val Ile Asp Thr Ile Thr Cys 
        115                 120                 125             


Gly Phe Ala Asp Leu Met Gly Tyr Ile Pro Val Val Gly Ala Pro Val 
    130                 135                 140                 


Gly Gly Val Ala Arg Ala Leu Ala His Gly Val Arg Val Leu Glu Asp 
145                 150                 155                 160 


Gly Ile Asn Tyr Ala Thr Arg Asn Leu Pro Gly Cys Ser Phe Ser Ile 
                165                 170                 175     


Phe Leu Leu Ala Leu Leu Ser Cys Val Thr Val Pro Val Ser Ser Val 
            180                 185                 190         


Glu Ile Arg Asn Ile Ser Thr Ser Tyr Tyr Ala Thr Asn Asp Cys Ser 
        195                 200                 205             


Asn Asn Ser Ile Thr Trp Gln Leu Thr Asn Ala Val Leu His Leu Pro 
    210                 215                 220                 


Gly Cys Val Pro Cys Glu Asn Asp Asn Gly Thr Leu Arg Cys Trp Ile 
225                 230                 235                 240 


Gln Val Thr Pro Asn Val Ala Val Lys His Arg Gly Ala Leu Thr His 
                245                 250                 255     


Asn Leu Arg Ala His Val Asp Val Ile Val Met Ala Ala Thr Val Cys 
            260                 265                 270         


Ser Ala Leu Tyr Val Gly Asp Val Cys Gly Ala Val Met Ile Val Ser 
        275                 280                 285             


Gln Ala Leu Ile Val Ser Pro Glu Arg His Asn Phe Thr Gln Glu Cys 
    290                 295                 300                 


Asn Cys Ser Ile Tyr Gln Gly His Ile Thr Gly Gln Arg Met Ala Trp 
305                 310                 315                 320 


Asp Met Met Leu Asn Trp Ser Pro Thr Leu Thr Met Ile Leu Ala Tyr 
                325                 330                 335     


Ala Ala Arg Val Pro Glu Leu Val Leu Glu Ile Val Phe Gly Gly His 
            340                 345                 350         


Trp Gly Val Val Phe Gly Leu Ala Tyr Phe Ser Met Gln Gly Ala Trp 
        355                 360                 365             


Ala Lys Val Ile Ala Ile Leu Leu Leu Val Ala Gly Val Asp Ala Thr 
    370                 375                 380                 


Thr Tyr Ser Thr Gly Ala Thr Val Gly Arg Thr Val Gly Ser Phe Ala 
385                 390                 395                 400 


Gly Leu Phe Lys Leu Gly Ala Gln Gln Asn Val Gln Leu Ile Asn Thr 
                405                 410                 415     


Asn Gly Ser Trp His Ile Asn Arg Thr Ala Leu Asn Cys Asn Asp Ser 
            420                 425                 430         


Leu His Thr Gly Phe Met Ala Ala Leu Phe Tyr Ala Asn Lys Phe Asn 
        435                 440                 445             


Ser Ser Gly Cys Pro Glu Arg Leu Ser Ser Cys Arg Gly Leu Asp Asp 
    450                 455                 460                 


Phe Arg Ile Gly Trp Gly Thr Leu Glu Tyr Glu Thr Asn Val Thr Asn 
465                 470                 475                 480 


Val Glu Asp Met Arg Pro Tyr Cys Trp His Tyr Pro Pro Lys Pro Cys 
                485                 490                 495     


Gly Ile Val Pro Ala Gln Ser Val Cys Gly Pro Val Tyr Cys Phe Thr 
            500                 505                 510         


Pro Ser Pro Val Val Val Gly Thr Thr Asp Arg Gln Gly Val Pro Thr 
        515                 520                 525             


Tyr Asn Trp Gly Asp Asn Glu Thr Asp Val Phe Leu Leu Asn Ser Thr 
    530                 535                 540                 


Arg Pro Pro Arg Gly Ala Trp Phe Gly Cys Thr Trp Met Asn Gly Thr 
545                 550                 555                 560 


Gly Phe Thr Lys Thr Cys Gly Ala Pro Pro Cys Arg Ile Arg Lys Asp 
                565                 570                 575     


Phe Asn Ser Thr Leu Asp Leu Leu Cys Pro Thr Asp Cys Phe Arg Lys 
            580                 585                 590         


His Pro Asp Ala Thr Tyr Val Lys Cys Gly Ala Gly Pro Trp Leu Thr 
        595                 600                 605             


Pro Arg Cys Leu Ile Asp Tyr Pro Tyr Arg Leu Trp His Tyr Pro Cys 
    610                 615                 620                 


Thr Val Asn Phe Thr Ile Phe Lys Val Arg Met Tyr Val Gly Gly Val 
625                 630                 635                 640 


Glu His Arg Phe Ser Ala Ala Cys Asn Phe Thr Arg Gly Asp Arg Cys 
                645                 650                 655     


Arg Leu Glu Asp Arg Asp Arg Gly Gln Gln Ser Pro Leu Leu His Ser 
            660                 665                 670         


Thr Thr Glu Trp Ala Val Leu Pro Cys Ser Phe Ser Asp Leu Pro Ala 
        675                 680                 685             


Leu Ser Thr Gly Leu Leu His Leu His Gln Asn Ile Val Asp Val Gln 
    690                 695                 700                 


Tyr Leu Tyr Gly Leu Ser Pro Ala Val Thr Lys Tyr Ile Val Lys Trp 
705                 710                 715                 720 


Glu Trp Val Val Leu Leu Phe Leu Leu Leu Ala Asp Ala Arg Ile Cys 
                725                 730                 735     


Ala Cys Leu Trp Met Leu Ile Ile Leu Gly Gln Ala Glu Ala 
            740                 745                 750 


<210>  42
<211>  750
<212>  PRT
<213>  Hepatitis C virus


<220>
<221>  misc_feature
<222>  (203)..(203)
<223>  Xaa can be any amino acid

<220>
<221>  misc_feature
<222>  (295)..(295)
<223>  Xaa can be any amino acid

<220>
<221>  misc_feature
<222>  (343)..(343)
<223>  Xaa can be any amino acid

<220>
<221>  misc_feature
<222>  (401)..(401)
<223>  Xaa can be any amino acid

<220>
<221>  misc_feature
<222>  (426)..(426)
<223>  Xaa can be any amino acid

<220>
<221>  misc_feature
<222>  (626)..(626)
<223>  Xaa can be any amino acid

<400>  42

Met Ser Thr Asp Pro Lys Pro Gln Arg Lys Thr Lys Arg Asn Thr Asn 
1               5                   10                  15      


Arg Arg Pro Gln Asp Val Lys Phe Pro Gly Gly Gly Gln Ile Val Gly 
            20                  25                  30          


Gly Val Tyr Leu Leu Pro Arg Arg Gly Pro Arg Leu Gly Val Arg Ala 
        35                  40                  45              


Ala Arg Lys Thr Ser Glu Arg Ser Gln Pro Arg Gly Arg Arg Gln Pro 
    50                  55                  60                  


Ile Pro Lys Asp Arg Arg Ser Pro Gly Lys Ser Trp Gly Lys Pro Gly 
65                  70                  75                  80  


Tyr Pro Trp Pro Leu Tyr Gly Asn Glu Gly Cys Gly Trp Ala Gly Trp 
                85                  90                  95      


Leu Leu Ser Pro Arg Gly Ser Arg Pro Thr Trp Gly Pro Thr Asp Pro 
            100                 105                 110         


Arg His Arg Ser Arg Asn Leu Gly Lys Val Ile Asp Thr Ile Thr Cys 
        115                 120                 125             


Gly Phe Ala Asp Leu Met Gly Tyr Ile Pro Val Val Gly Ala Pro Val 
    130                 135                 140                 


Gly Gly Val Ala Arg Ala Leu Ala His Gly Val Arg Val Leu Glu Asp 
145                 150                 155                 160 


Gly Ile Asn Tyr Ala Thr Gly Asn Leu Pro Gly Cys Ser Phe Ser Ile 
                165                 170                 175     


Phe Leu Leu Ala Leu Leu Ser Cys Leu Thr Val Pro Ala Ser Ala Val 
            180                 185                 190         


Glu Val Arg Asn Ile Ser Ser Gly Tyr Tyr Xaa Thr Asn Asp Cys Ser 
        195                 200                 205             


Asn Ser Ser Ile Thr Trp Gln Leu Thr Asn Ala Val Leu His Leu Pro 
    210                 215                 220                 


Gly Cys Val Pro Cys Glu Asn Asp Asn Gly Thr Leu Arg Cys Trp Ile 
225                 230                 235                 240 


Gln Val Thr Pro Asn Val Ala Val Lys Tyr Arg Gly Ala Leu Thr His 
                245                 250                 255     


Asn Leu Arg Thr His Val Asp Met Ile Val Met Ala Ala Thr Val Cys 
            260                 265                 270         


Ser Ala Leu Tyr Val Gly Asp Val Cys Gly Ala Val Met Ile Val Ser 
        275                 280                 285             


Gln Ala Phe Ile Met Ser Xaa Glu Arg His Asn Phe Thr Gln Glu Cys 
    290                 295                 300                 


Asn Cys Ser Ile Tyr Gln Gly His Ile Thr Gly His Arg Met Ala Trp 
305                 310                 315                 320 


Asp Met Met Leu Gly Trp Ser Pro Thr Leu Thr Met Ile Leu Ala Tyr 
                325                 330                 335     


Ala Ala Arg Val Pro Glu Xaa Val Leu Glu Val Val Phe Gly Gly His 
            340                 345                 350         


Trp Gly Val Val Phe Gly Leu Ala Tyr Phe Ser Met Gln Gly Ala Trp 
        355                 360                 365             


Ala Lys Val Ile Ala Ile Leu Leu Leu Val Ala Gly Val Asp Ala Gly 
    370                 375                 380                 


Thr Tyr Ser Ser Gly Ala Thr Ile Gly Gln Gly Thr Arg Gly Leu Val 
385                 390                 395                 400 


Xaa Leu Phe Ser Ala Gly Pro Ser Gln Lys Ile Ser Leu Ile Asn Thr 
                405                 410                 415     


Asn Gly Ser Trp His Ile Asn Arg Thr Xaa Leu Asn Cys Asn Asp Ser 
            420                 425                 430         


Leu Gln Thr Gly Phe Ile Ala Ser Leu Phe Tyr Ala Lys Ser Phe Asn 
        435                 440                 445             


Ser Ser Gly Cys Pro Glu Arg Leu Ser Ser Cys Arg Gly Leu Asp Asp 
    450                 455                 460                 


Phe Arg Ile Gly Trp Gly Thr Leu Glu Tyr Glu Asn Asn Val Thr Asn 
465                 470                 475                 480 


Asp Glu Asp Met Arg Pro Tyr Cys Trp His Tyr Pro Pro Lys Pro Cys 
                485                 490                 495     


Gly Ile Val Pro Ala Arg Thr Val Cys Gly Pro Val Tyr Cys Phe Thr 
            500                 505                 510         


Pro Ser Pro Val Val Val Gly Thr Thr Asp Lys Gln Gly Val Pro Thr 
        515                 520                 525             


Tyr Ser Trp Gly Glu Asn Glu Thr Asp Val Phe Leu Leu Asn Ser Thr 
    530                 535                 540                 


Arg Pro Pro Gln Gly Ala Trp Phe Gly Cys Thr Trp Met Asn Gly Thr 
545                 550                 555                 560 


Gly Phe Thr Lys Thr Cys Gly Ala Pro Pro Cys Arg Ile Arg Arg Asp 
                565                 570                 575     


His Thr Ser Thr Leu Asp Leu Leu Cys Pro Thr Asp Cys Phe Arg Lys 
            580                 585                 590         


His Pro Asp Thr Thr Tyr Leu Lys Cys Gly Ala Gly Pro Trp Leu Thr 
        595                 600                 605             


Pro Lys Cys Leu Val Asp Tyr Pro Tyr Arg Leu Trp His Tyr Pro Cys 
    610                 615                 620                 


Thr Xaa Asn Phe Thr Ile Phe Lys Val Arg Met Tyr Val Gly Gly Val 
625                 630                 635                 640 


Glu His Arg Phe Ser Ala Ala Cys Asn Phe Thr Arg Gly Asp Arg Cys 
                645                 650                 655     


Arg Leu Glu Asp Arg Asp Arg Gly Gln Gln Ser Pro Leu Leu His Ser 
            660                 665                 670         


Thr Thr Glu Trp Ala Val Leu Pro Cys Ser Phe Ser Asp Leu Pro Ala 
        675                 680                 685             


Leu Ser Thr Gly Leu Leu His Leu His Gln Asn Ile Val Asp Val Gln 
    690                 695                 700                 


Tyr Leu Tyr Gly Leu Ser Pro Ala Ile Thr Lys Tyr Ile Val Lys Trp 
705                 710                 715                 720 


Glu Trp Val Ile Leu Leu Phe Leu Leu Leu Ala Asp Ala Arg Val Cys 
                725                 730                 735     


Ala Cys Leu Trp Met Leu Ile Ile Leu Gly Gln Ala Glu Ala 
            740                 745                 750 


<210>  43
<211>  752
<212>  PRT
<213>  Hepatitis C virus


<220>
<221>  misc_feature
<222>  (431)..(431)
<223>  Xaa can be any amino acid

<220>
<221>  misc_feature
<222>  (466)..(466)
<223>  Xaa can be any amino acid

<400>  43

Met Ser Thr Leu Pro Lys Pro Gln Arg Lys Thr Lys Arg Asn Thr Ile 
1               5                   10                  15      


Arg Arg Pro Gln Asp Val Lys Phe Pro Gly Gly Gly Gln Ile Val Gly 
            20                  25                  30          


Gly Val Tyr Val Leu Pro Arg Arg Gly Pro Arg Leu Gly Val Arg Ala 
        35                  40                  45              


Thr Arg Lys Thr Ser Glu Arg Ser Gln Pro Arg Gly Arg Arg Gln Pro 
    50                  55                  60                  


Ile Pro Lys Ala Arg Arg Ser Glu Gly Arg Ser Trp Ala Gln Pro Gly 
65                  70                  75                  80  


Tyr Pro Trp Pro Leu Tyr Gly Asn Glu Gly Cys Gly Trp Ala Gly Trp 
                85                  90                  95      


Leu Leu Ser Pro Arg Gly Ser Arg Pro Ser Trp Gly Pro Asn Asp Pro 
            100                 105                 110         


Arg Arg Arg Ser Arg Asn Leu Gly Lys Val Ile Asp Thr Leu Thr Cys 
        115                 120                 125             


Gly Phe Ala Asp Leu Met Gly Tyr Ile Pro Leu Val Gly Ala Pro Val 
    130                 135                 140                 


Gly Gly Val Ala Arg Ala Leu Ala His Gly Val Arg Ala Leu Glu Asp 
145                 150                 155                 160 


Gly Ile Asn Phe Ala Thr Gly Asn Leu Pro Gly Cys Ser Phe Ser Ile 
                165                 170                 175     


Phe Leu Leu Ala Leu Phe Ser Cys Leu Ile His Pro Ala Ala Ser Leu 
            180                 185                 190         


Glu Trp Arg Asn Thr Ser Gly Leu Tyr Val Leu Thr Asn Asp Cys Ser 
        195                 200                 205             


Asn Ser Ser Ile Val Tyr Glu Ala Asp Asp Val Ile Leu His Thr Pro 
    210                 215                 220                 


Gly Cys Val Pro Cys Val Gln Asp Gly Asn Thr Ser Thr Cys Trp Thr 
225                 230                 235                 240 


Pro Val Thr Pro Thr Val Ala Val Arg Tyr Val Gly Ala Thr Thr Ala 
                245                 250                 255     


Ser Ile Arg Ser His Val Asp Leu Leu Val Gly Ala Ala Thr Met Cys 
            260                 265                 270         


Ser Ala Leu Tyr Val Gly Asp Met Cys Gly Ala Val Phe Leu Val Gly 
        275                 280                 285             


Gln Ala Phe Thr Phe Arg Pro Arg Arg His Gln Thr Val Gln Thr Cys 
    290                 295                 300                 


Asn Cys Ser Leu Tyr Pro Gly His Leu Ser Gly His Arg Met Ala Trp 
305                 310                 315                 320 


Asp Met Met Met Asn Trp Ser Pro Ala Val Gly Met Val Val Ala His 
                325                 330                 335     


Val Leu Arg Leu Pro Gln Thr Leu Phe Asp Ile Ile Ala Gly Ala His 
            340                 345                 350         


Trp Gly Ile Leu Ala Gly Leu Ala Tyr Tyr Ser Met Gln Gly Asn Trp 
        355                 360                 365             


Ala Lys Val Ala Ile Ile Met Val Met Phe Ser Gly Val Asp Ala Thr 
    370                 375                 380                 


Thr Tyr Thr Thr Gly Gly Ser Ala Ala Arg Gly Ala Arg Gly Leu Thr 
385                 390                 395                 400 


Ser Leu Phe Ser Val Gly Ala Lys Gln Lys Leu Gln Leu Val Asn Thr 
                405                 410                 415     


Asn Gly Ser Trp His Ile Asn Ser Thr Ala Leu Asn Cys Asn Xaa Ser 
            420                 425                 430         


Ile Asn Thr Gly Phe Ile Ala Gly Leu Phe Tyr Tyr His Lys Phe Asn 
        435                 440                 445             


Ser Thr Gly Cys Pro Gln Arg Leu Ser Ser Cys Lys Pro Ile Thr Phe 
    450                 455                 460                 


Phe Xaa Gln Gly Trp Gly Pro Leu Thr Asp Ala Asn Ile Thr Gly Pro 
465                 470                 475                 480 


Ser Asp Asp Lys Pro Tyr Cys Trp His Tyr Ala Pro Arg Pro Cys Asp 
                485                 490                 495     


Val Val Pro Ala Ser Ser Val Cys Gly Pro Val Tyr Cys Phe Thr Pro 
            500                 505                 510         


Ser Pro Val Val Val Gly Thr Thr Asp Ala Lys Gly Val Pro Thr Tyr 
        515                 520                 525             


Thr Trp Gly Glu Asn Glu Thr Asp Val Phe Leu Leu Glu Ser Leu Arg 
    530                 535                 540                 


Pro Pro Ser Gly Arg Trp Phe Gly Cys Thr Trp Met Asn Ser Thr Gly 
545                 550                 555                 560 


Phe Val Lys Thr Cys Gly Ala Pro Pro Cys Asn Ile Tyr Gly Gly Gly 
                565                 570                 575     


Gly Asn Pro His Asn Glu Ser Asp Leu Phe Cys Pro Thr Asp Cys Phe 
            580                 585                 590         


Arg Lys His Pro Glu Ala Thr Tyr Ser Arg Cys Gly Ala Gly Pro Trp 
        595                 600                 605             


Leu Thr Pro Arg Cys Met Val Asp Tyr Pro Tyr Arg Leu Trp His Tyr 
    610                 615                 620                 


Pro Cys Thr Val Asn Phe Thr Leu Phe Lys Val Arg Met Phe Val Gly 
625                 630                 635                 640 


Gly Phe Glu His Arg Phe Thr Ala Ala Cys Asn Trp Thr Arg Gly Glu 
                645                 650                 655     


Arg Cys Asp Ile Glu Asp Arg Asp Arg Ser Glu Gln His Pro Leu Leu 
            660                 665                 670         


His Ser Thr Thr Glu Leu Ala Ile Leu Pro Cys Ser Phe Thr Pro Met 
        675                 680                 685             


Pro Ala Leu Ser Thr Gly Leu Ile His Leu His Gln Asn Ile Val Asp 
    690                 695                 700                 


Val Gln Tyr Leu Tyr Gly Val Gly Ser Gly Met Val Gly Trp Ala Leu 
705                 710                 715                 720 


Lys Trp Glu Phe Val Ile Leu Val Phe Leu Leu Leu Ala Asp Ala Arg 
                725                 730                 735     


Val Cys Val Ala Leu Trp Leu Met Leu Met Ile Ser Gln Ala Glu Ala 
            740                 745                 750         


<210>  44
<211>  752
<212>  PRT
<213>  Hepatitis C virus

<400>  44

Met Ser Thr Leu Pro Lys Pro Gln Arg Lys Thr Lys Arg Asn Thr Ile 
1               5                   10                  15      


Arg Arg Pro Gln Asp Val Lys Phe Pro Gly Gly Gly Gln Ile Val Gly 
            20                  25                  30          


Gly Val Tyr Val Leu Pro Arg Arg Gly Pro Arg Leu Gly Val Arg Ala 
        35                  40                  45              


Thr Arg Lys Thr Ser Glu Arg Ser Gln Pro Arg Glu Arg Arg Gln Pro 
    50                  55                  60                  


Ile Pro Lys Ala Arg Arg Ser Asp Gly Arg Ser Trp Ala Gln Pro Gly 
65                  70                  75                  80  


Tyr Pro Trp Pro Leu Tyr Gly Asn Glu Gly Cys Gly Trp Ala Gly Trp 
                85                  90                  95      


Leu Leu Ser Pro Arg Gly Ser Arg Pro Ser Trp Gly Pro Asn Asp Pro 
            100                 105                 110         


Arg Arg Arg Ser Arg Asn Leu Gly Lys Val Ile Asp Thr Leu Thr Cys 
        115                 120                 125             


Gly Phe Ala Asp Leu Met Gly Tyr Ile Pro Ile Val Gly Ala Pro Val 
    130                 135                 140                 


Gly Gly Val Ala Arg Ala Leu Ala His Gly Val Arg Ala Leu Glu Asp 
145                 150                 155                 160 


Gly Ile Asn Phe Ala Thr Gly Asn Leu Pro Gly Cys Ser Phe Ser Ile 
                165                 170                 175     


Phe Leu Leu Ala Leu Leu Ser Cys Leu Ile His Pro Ala Ala Ser Leu 
            180                 185                 190         


Glu Trp Arg Asn Thr Ser Gly Leu Tyr Ile Leu Thr Asn Asp Cys Pro 
        195                 200                 205             


Asn Ser Ser Ile Val Tyr Glu Ala Asp Asp Val Ile Leu His Thr Pro 
    210                 215                 220                 


Gly Cys Ile Pro Cys Val Gln Asp Gly Asn Thr Ser Thr Cys Trp Thr 
225                 230                 235                 240 


Ser Val Ser Pro Thr Val Ala Val Arg Tyr Val Gly Ala Thr Thr Ala 
                245                 250                 255     


Ser Ile Arg Ser His Val Asp Leu Leu Val Gly Ala Ala Thr Leu Cys 
            260                 265                 270         


Ser Ala Leu Tyr Val Gly Asp Met Cys Gly Ala Val Phe Leu Val Gly 
        275                 280                 285             


Gln Ala Phe Thr Phe Arg Pro Arg Arg His Gln Thr Val Gln Thr Cys 
    290                 295                 300                 


Asn Cys Ser Leu Tyr Pro Gly His Leu Thr Gly His Arg Met Ala Trp 
305                 310                 315                 320 


Asp Met Met Met Asn Trp Ser Pro Ala Val Gly Met Val Val Ala His 
                325                 330                 335     


Val Leu Arg Met Pro Gln Thr Val Phe Asp Ile Ile Ala Gly Ala His 
            340                 345                 350         


Trp Gly Ile Leu Ala Gly Leu Ala Tyr Tyr Ser Met Gln Gly Asn Trp 
        355                 360                 365             


Ala Lys Val Ala Ile Ile Met Val Met Phe Ser Gly Val Asp Ala Glu 
    370                 375                 380                 


Thr His Thr Thr Gly Gly Thr Ala Ala Arg Asn Ala Phe Thr Leu Thr 
385                 390                 395                 400 


Gly Leu Phe Thr Gln Gly Ala Arg Gln Lys Leu Glu Leu Ile Asn Thr 
                405                 410                 415     


Asn Gly Ser Trp His Ile Asn Arg Thr Ala Leu Asn Cys Asn Glu Ser 
            420                 425                 430         


Leu Asn Thr Gly Phe Ile Ala Gly Leu Phe Tyr Leu His Lys Phe Asn 
        435                 440                 445             


Ser Thr Gly Cys Pro Glu Arg Leu Ser Ser Cys Lys Pro Ile Thr Phe 
    450                 455                 460                 


Phe Arg Gln Gly Trp Gly Ser Leu Thr Asp Ala Asn Ile Thr Gly Pro 
465                 470                 475                 480 


Ser Asp Asp Lys Pro Tyr Cys Trp His Tyr Ala Pro Arg Pro Cys Glu 
                485                 490                 495     


Val Val Pro Ala Leu Asn Val Cys Gly Pro Val Tyr Cys Phe Thr Pro 
            500                 505                 510         


Ser Pro Val Val Val Gly Thr Thr Asp Arg Gln Gly Val Pro Thr Tyr 
        515                 520                 525             


Thr Trp Gly Glu Asn Glu Thr Asp Val Phe Leu Leu Arg Ser Leu Arg 
    530                 535                 540                 


Pro Pro Ser Gly Gln Trp Phe Gly Cys Thr Trp Met Asn Ser Thr Gly 
545                 550                 555                 560 


Phe Val Lys Thr Cys Gly Ala Pro Pro Cys Asp Ile Tyr Gly Gly Gly 
                565                 570                 575     


Gly Asn Arg Cys Asn Glu Ser Asp Leu Phe Cys Pro Thr Asp Cys Phe 
            580                 585                 590         


Arg Lys His Pro Glu Ala Thr Tyr Ser Arg Cys Gly Ala Gly Pro Trp 
        595                 600                 605             


Leu Thr Pro Arg Cys Leu Val Asp Tyr Pro Tyr Arg Leu Trp His Tyr 
    610                 615                 620                 


Pro Cys Thr Val Asn Phe Thr Leu Phe Lys Val Arg Met Phe Val Gly 
625                 630                 635                 640 


Gly Phe Glu His Arg Phe Thr Ala Ala Cys Asn Trp Thr Arg Gly Glu 
                645                 650                 655     


Arg Cys Asn Ile Glu Asp Arg Asp Arg Ser Glu Gln His Pro Leu Leu 
            660                 665                 670         


His Ser Thr Thr Glu Leu Ala Ile Leu Pro Cys Ser Phe Thr Pro Met 
        675                 680                 685             


Pro Ala Leu Ser Thr Gly Leu Ile His Leu His Gln Asn Ile Val Asp 
    690                 695                 700                 


Val Gln Tyr Leu Tyr Gly Val Gly Ser Gly Val Val Gly Trp Ala Leu 
705                 710                 715                 720 


Arg Trp Glu Phe Val Val Leu Val Phe Leu Leu Leu Ala Asp Ala Arg 
                725                 730                 735     


Val Cys Val Ala Leu Trp Leu Met Leu Met Ile Ser Gln Ala Glu Ala 
            740                 745                 750         


<210>  45
<211>  752
<212>  PRT
<213>  Hepatitis C virus

<400>  45

Met Ser Thr Leu Pro Lys Pro Gln Arg Lys Thr Lys Arg Asn Thr Ile 
1               5                   10                  15      


Arg Arg Pro Gln Asp Val Lys Phe Pro Gly Gly Gly Gln Ile Val Gly 
            20                  25                  30          


Gly Val Tyr Val Leu Pro Arg Arg Gly Pro Arg Leu Gly Val Arg Ala 
        35                  40                  45              


Thr Arg Lys Thr Ser Glu Arg Ser Gln Pro Arg Gly Arg Arg Gln Pro 
    50                  55                  60                  


Ile Pro Lys Ala Arg Arg Ser Glu Gly Arg Ser Trp Ala Gln Pro Gly 
65                  70                  75                  80  


Tyr Pro Trp Pro Leu Tyr Gly Asn Glu Gly Cys Gly Trp Ala Gly Trp 
                85                  90                  95      


Leu Leu Ser Pro Arg Gly Ser Arg Pro Ser Trp Gly Pro Asn Asp Pro 
            100                 105                 110         


Arg Arg Arg Ser Arg Asn Leu Gly Lys Val Ile Asp Thr Leu Thr Cys 
        115                 120                 125             


Gly Phe Ala Asp Leu Met Gly Tyr Ile Pro Leu Val Gly Ala Pro Val 
    130                 135                 140                 


Gly Gly Val Ala Arg Ala Leu Ala His Gly Val Arg Ala Leu Glu Asp 
145                 150                 155                 160 


Gly Ile Asn Phe Ala Thr Gly Asn Leu Pro Gly Cys Ser Phe Ser Ile 
                165                 170                 175     


Phe Leu Leu Ala Leu Phe Ser Cys Leu Val His Pro Ala Ala Ser Leu 
            180                 185                 190         


Glu Trp Arg Asn Thr Ser Gly Leu Tyr Val Leu Thr Asn Asp Cys Ser 
        195                 200                 205             


Asn Ser Ser Ile Val Tyr Glu Ala Asp Asp Val Ile Leu His Thr Pro 
    210                 215                 220                 


Gly Cys Val Pro Cys Val Gln Asp Asp Asn Thr Ser Thr Cys Trp Thr 
225                 230                 235                 240 


Pro Val Thr Pro Thr Val Ala Val Arg Tyr Val Gly Ala Thr Thr Ala 
                245                 250                 255     


Ser Ile Arg Ser His Val Asp Leu Leu Val Gly Ala Ala Thr Leu Cys 
            260                 265                 270         


Ser Ala Leu Tyr Val Gly Asp Met Cys Gly Ala Val Phe Leu Val Gly 
        275                 280                 285             


Gln Ala Phe Thr Phe Arg Pro Arg Arg His Gln Thr Val Gln Thr Cys 
    290                 295                 300                 


Asn Cys Ser Leu Tyr Pro Gly His Val Ser Gly His Arg Met Ala Trp 
305                 310                 315                 320 


Asp Met Met Met Asn Trp Ser Pro Ala Val Gly Met Val Val Ala His 
                325                 330                 335     


Ile Leu Arg Leu Pro Gln Thr Leu Phe Asp Ile Leu Ala Gly Ala His 
            340                 345                 350         


Trp Gly Ile Leu Ala Gly Leu Ala Tyr Tyr Ser Met Gln Gly Asn Trp 
        355                 360                 365             


Ala Lys Val Ala Ile Val Met Ile Met Phe Ser Gly Val Asp Ala Glu 
    370                 375                 380                 


Thr Tyr Val Thr Gly Gly Ser Val Ala His Ser Ala Arg Gly Leu Thr 
385                 390                 395                 400 


Ser Leu Phe Ser Met Gly Ala Lys Gln Lys Leu Gln Leu Val Asn Thr 
                405                 410                 415     


Asn Gly Ser Trp His Ile Asn Ser Thr Ala Leu Asn Cys Asn Glu Ser 
            420                 425                 430         


Ile Asn Thr Gly Phe Ile Ala Gly Leu Phe Tyr Tyr His Lys Phe Asn 
        435                 440                 445             


Ser Thr Gly Cys Pro Gln Arg Leu Ser Ser Cys Lys Pro Ile Ile Ser 
    450                 455                 460                 


Phe Arg Gln Gly Trp Gly Pro Leu Thr Asp Ala Asn Ile Thr Gly Pro 
465                 470                 475                 480 


Ser Asp Asp Arg Pro Tyr Cys Trp His Tyr Ala Pro Arg Pro Cys Ser 
                485                 490                 495     


Val Val Pro Ala Ser Ser Val Cys Gly Pro Val Tyr Cys Phe Thr Pro 
            500                 505                 510         


Ser Pro Val Val Val Gly Thr Thr Asp Ile Lys Gly Lys Pro Thr Tyr 
        515                 520                 525             


Asn Trp Gly Glu Asn Glu Thr Asp Val Phe Leu Leu Glu Ser Leu Arg 
    530                 535                 540                 


Pro Pro Ser Gly Arg Trp Phe Gly Cys Ala Trp Met Asn Ser Thr Gly 
545                 550                 555                 560 


Phe Leu Lys Thr Cys Gly Ala Pro Pro Cys Asn Ile Tyr Gly Gly Glu 
                565                 570                 575     


Gly Asp Pro Glu Asn Glu Thr Asp Leu Phe Cys Pro Thr Asp Cys Phe 
            580                 585                 590         


Arg Lys His Pro Glu Ala Thr Tyr Ser Arg Cys Gly Ala Gly Pro Trp 
        595                 600                 605             


Leu Thr Pro Arg Cys Met Val Asp Tyr Pro Tyr Arg Leu Trp His Tyr 
    610                 615                 620                 


Pro Cys Thr Val Asn Phe Thr Leu Phe Lys Val Arg Met Phe Val Gly 
625                 630                 635                 640 


Gly Phe Glu His Arg Phe Thr Ala Ala Cys Asn Trp Thr Arg Gly Glu 
                645                 650                 655     


Arg Cys Asn Ile Glu Asp Arg Asp Arg Ser Glu Gln His Pro Leu Leu 
            660                 665                 670         


His Ser Thr Thr Glu Leu Ala Ile Leu Pro Cys Ser Phe Thr Pro Met 
        675                 680                 685             


Pro Ala Leu Ser Thr Gly Leu Ile His Leu His Gln Asn Ile Val Asp 
    690                 695                 700                 


Val Gln Tyr Leu Tyr Gly Val Gly Ser Asp Met Val Gly Trp Ala Leu 
705                 710                 715                 720 


Lys Trp Glu Phe Val Ile Leu Val Phe Leu Leu Leu Ala Asp Ala Arg 
                725                 730                 735     


Val Cys Val Ala Leu Trp Leu Met Leu Met Val Ser Gln Ala Glu Ala 
            740                 745                 750         


<210>  46
<211>  752
<212>  PRT
<213>  Hepatitis C virus

<400>  46

Met Ser Thr Leu Pro Lys Pro Gln Arg Lys Thr Lys Arg Asn Thr Ile 
1               5                   10                  15      


Arg Arg Pro Gln Asp Val Lys Phe Pro Gly Gly Gly Gln Ile Val Gly 
            20                  25                  30          


Gly Val Tyr Val Leu Pro Arg Arg Gly Pro Arg Leu Gly Val Arg Ala 
        35                  40                  45              


Thr Arg Lys Thr Ser Glu Arg Ser Gln Pro Arg Gly Arg Arg Gln Pro 
    50                  55                  60                  


Ile Pro Lys Ala Arg Arg Ser Glu Gly Arg Ser Trp Ala Gln Pro Gly 
65                  70                  75                  80  


Tyr Pro Trp Pro Leu Tyr Gly Asn Glu Gly Cys Gly Trp Ala Gly Trp 
                85                  90                  95      


Leu Leu Ser Pro Arg Gly Ser Arg Pro Ser Trp Gly Pro Asn Asp Pro 
            100                 105                 110         


Arg Arg Arg Ser Arg Asn Leu Gly Lys Val Ile Asp Thr Leu Thr Cys 
        115                 120                 125             


Gly Phe Ala Asp Leu Met Gly Tyr Ile Pro Leu Val Gly Ala Pro Val 
    130                 135                 140                 


Gly Gly Val Ala Arg Ala Leu Ala His Gly Val Arg Ala Leu Glu Asp 
145                 150                 155                 160 


Gly Ile Asn Phe Ala Thr Gly Asn Leu Pro Gly Cys Ser Phe Ser Ile 
                165                 170                 175     


Phe Leu Leu Ala Leu Phe Ser Cys Leu Ile His Pro Ala Ala Ser Leu 
            180                 185                 190         


Glu Trp Arg Asn Thr Ser Gly Leu Tyr Val Leu Thr Asn Asp Cys Ser 
        195                 200                 205             


Asn Ser Ser Ile Val Tyr Glu Ala Asp Asp Val Ile Leu His Thr Pro 
    210                 215                 220                 


Gly Cys Val Pro Cys Val Gln Asp Gly Asn Thr Ser Thr Cys Trp Thr 
225                 230                 235                 240 


Pro Val Thr Pro Thr Val Ala Val Arg Tyr Val Gly Ala Thr Thr Ala 
                245                 250                 255     


Ser Ile Arg Ser His Val Asp Leu Leu Val Gly Ala Ala Thr Met Cys 
            260                 265                 270         


Ser Ala Leu Tyr Val Gly Asp Met Cys Gly Ala Val Phe Leu Val Gly 
        275                 280                 285             


Gln Ala Phe Thr Phe Arg Pro Arg Arg His Gln Thr Val Gln Thr Cys 
    290                 295                 300                 


Asn Cys Ser Leu Tyr Pro Gly His Leu Ser Gly His Arg Met Ala Trp 
305                 310                 315                 320 


Asp Met Met Met Asn Trp Ser Pro Ala Val Gly Met Val Val Ala His 
                325                 330                 335     


Val Leu Arg Leu Pro Gln Thr Leu Phe Asp Ile Met Ala Gly Ala His 
            340                 345                 350         


Trp Gly Ile Leu Ala Gly Leu Ala Tyr Tyr Ser Met Gln Gly Asn Trp 
        355                 360                 365             


Ala Lys Val Ala Ile Ile Met Val Met Phe Ser Gly Val Asp Ala His 
    370                 375                 380                 


Thr Tyr Thr Thr Gly Gly Thr Ala Ser Arg His Thr Gln Ala Phe Ala 
385                 390                 395                 400 


Gly Leu Phe Asp Ile Gly Pro Gln Gln Lys Leu Gln Leu Val Asn Thr 
                405                 410                 415     


Asn Gly Ser Trp His Ile Asn Ser Thr Ala Leu Asn Cys Asn Glu Ser 
            420                 425                 430         


Ile Asn Thr Gly Phe Ile Ala Gly Leu Phe Tyr Tyr His Lys Phe Asn 
        435                 440                 445             


Ser Thr Gly Cys Pro Gln Arg Leu Ser Ser Cys Lys Pro Ile Thr Phe 
    450                 455                 460                 


Phe Arg Gln Gly Trp Gly Pro Leu Thr Asp Ala Asn Ile Thr Gly Pro 
465                 470                 475                 480 


Ser Asp Asp Arg Pro Tyr Cys Trp His Tyr Ala Pro Arg Pro Cys Asp 
                485                 490                 495     


Ile Val Pro Ala Ser Ser Val Cys Gly Pro Val Tyr Cys Phe Thr Pro 
            500                 505                 510         


Ser Pro Val Val Val Gly Thr Thr Asp Ala Arg Gly Val Pro Thr Tyr 
        515                 520                 525             


Thr Trp Gly Glu Asn Glu Lys Asp Val Phe Leu Leu Lys Ser Gln Arg 
    530                 535                 540                 


Pro Pro Ser Gly Arg Trp Phe Gly Cys Ser Trp Met Asn Ser Thr Gly 
545                 550                 555                 560 


Phe Leu Lys Thr Cys Gly Ala Pro Pro Cys Asn Ile Tyr Gly Gly Glu 
                565                 570                 575     


Gly Asn Pro His Asn Glu Ser Asp Leu Phe Cys Pro Thr Asp Cys Phe 
            580                 585                 590         


Arg Lys His Pro Glu Thr Thr Tyr Ser Arg Cys Gly Ala Gly Pro Trp 
        595                 600                 605             


Leu Thr Pro Arg Cys Met Val Asp Tyr Pro Tyr Arg Leu Trp His Tyr 
    610                 615                 620                 


Pro Cys Thr Val Asp Phe Arg Leu Phe Lys Val Arg Met Phe Val Gly 
625                 630                 635                 640 


Gly Phe Glu His Arg Phe Thr Ala Ala Cys Asn Trp Thr Arg Gly Glu 
                645                 650                 655     


Arg Cys Asp Ile Glu Asp Arg Asp Arg Ser Glu Gln His Pro Leu Leu 
            660                 665                 670         


His Ser Thr Thr Glu Leu Ala Ile Leu Pro Cys Ser Phe Thr Pro Met 
        675                 680                 685             


Pro Ala Leu Ser Thr Gly Leu Ile His Leu His Gln Asn Ile Val Asp 
    690                 695                 700                 


Val Gln Tyr Leu Tyr Gly Val Gly Ser Gly Met Val Gly Trp Ala Leu 
705                 710                 715                 720 


Lys Trp Glu Phe Val Ile Leu Val Phe Leu Leu Leu Ala Asp Ala Arg 
                725                 730                 735     


Val Cys Val Ala Leu Trp Leu Met Leu Met Ile Ser Gln Thr Glu Ala 
            740                 745                 750         


<210>  47
<211>  752
<212>  PRT
<213>  Hepatitis C virus

<400>  47

Met Ser Thr Leu Pro Lys Pro Gln Arg Lys Thr Lys Arg Asn Thr Ile 
1               5                   10                  15      


Arg Arg Pro Gln Asp Val Lys Phe Pro Gly Gly Gly Gln Ile Val Gly 
            20                  25                  30          


Gly Val Tyr Val Leu Pro Arg Arg Gly Pro Arg Leu Gly Val Arg Ala 
        35                  40                  45              


Thr Arg Lys Thr Ser Glu Arg Ser Gln Pro Arg Gly Arg Arg Gln Pro 
    50                  55                  60                  


Ile Pro Lys Ala Arg Arg Ser Glu Gly Arg Ser Trp Ala Gln Pro Gly 
65                  70                  75                  80  


Tyr Pro Trp Pro Leu Tyr Gly Asn Glu Gly Cys Gly Trp Ala Gly Trp 
                85                  90                  95      


Leu Leu Ser Pro Arg Gly Ser Arg Pro Ser Trp Gly Gln Asn Asp Pro 
            100                 105                 110         


Arg Arg Arg Ser Arg Asn Leu Gly Lys Val Ile Asp Thr Leu Thr Cys 
        115                 120                 125             


Gly Phe Ala Asp Leu Met Gly Tyr Ile Pro Leu Val Gly Ala Pro Val 
    130                 135                 140                 


Gly Gly Val Ala Arg Ala Leu Ala His Gly Val Arg Ala Leu Glu Asp 
145                 150                 155                 160 


Gly Ile Asn Phe Ala Thr Gly Asn Leu Pro Gly Cys Ser Phe Ser Ile 
                165                 170                 175     


Phe Leu Leu Ala Leu Phe Ser Cys Leu Ile His Pro Ala Ala Ser Leu 
            180                 185                 190         


Glu Trp Arg Asn Thr Ser Gly Leu Tyr Val Leu Thr Asn Asp Cys Ser 
        195                 200                 205             


Asn Ser Ser Ile Val Tyr Glu Ala Asp Asp Val Ile Leu His Thr Pro 
    210                 215                 220                 


Gly Cys Val Pro Cys Val Gln Asp Gly Asn Thr Ser Thr Cys Trp Thr 
225                 230                 235                 240 


Pro Val Thr Pro Thr Val Ala Val Arg Tyr Val Gly Ala Thr Thr Ala 
                245                 250                 255     


Ser Ile Arg Ser His Val Asp Leu Leu Val Gly Ala Ala Thr Met Cys 
            260                 265                 270         


Ser Ala Leu Tyr Val Gly Asp Met Cys Gly Ala Val Phe Leu Val Gly 
        275                 280                 285             


Gln Ala Phe Thr Phe Arg Pro Arg Arg His Gln Thr Val Gln Thr Cys 
    290                 295                 300                 


Asn Cys Ser Leu Tyr Pro Gly His Leu Ser Gly His Arg Met Ala Trp 
305                 310                 315                 320 


Asp Met Met Met Asn Trp Ser Pro Ala Val Gly Met Val Val Ser His 
                325                 330                 335     


Val Leu Arg Leu Pro Gln Thr Leu Phe Asp Ile Ile Ala Gly Ala His 
            340                 345                 350         


Trp Gly Ile Leu Ala Gly Leu Ala Tyr Tyr Ser Met Gln Gly Asn Trp 
        355                 360                 365             


Ala Lys Val Ala Val Ile Met Val Met Phe Ser Gly Val Asp Ala Glu 
    370                 375                 380                 


Thr Tyr Ile Thr Gly Gly Ser Ala Ala His Gly Val Ser Thr Leu Thr 
385                 390                 395                 400 


Ser Leu Phe Ser Ser Gly Pro Gln Gln Lys Leu Gln Leu Val Lys Thr 
                405                 410                 415     


Asn Gly Ser Trp His Ile Asn Ser Thr Ala Leu Asn Cys Asn Glu Ser 
            420                 425                 430         


Ile Asn Thr Gly Phe Ile Ala Gly Leu Phe Tyr Tyr His Lys Phe Asn 
        435                 440                 445             


Ser Thr Gly Cys Pro Gln Arg Leu Ser Ser Cys Lys Pro Ile Thr Phe 
    450                 455                 460                 


Phe Arg Gln Gly Trp Gly Ser Leu Thr Asp Ala Asn Val Thr Gly Ala 
465                 470                 475                 480 


Ser Ala Asp Lys Pro Tyr Cys Trp His Tyr Ala Pro Arg Pro Cys Asp 
                485                 490                 495     


Val Val Pro Ala Leu Asn Val Cys Gly Pro Val Tyr Cys Phe Thr Pro 
            500                 505                 510         


Ser Pro Val Val Val Gly Thr Thr Asp Arg Lys Gly Val Pro Thr Tyr 
        515                 520                 525             


Asn Trp Gly Glu Asn Glu Ser Asp Val Phe Leu Leu Glu Ser Leu Arg 
    530                 535                 540                 


Pro Pro Ser Gly Arg Trp Phe Gly Cys Ala Trp Met Asn Ser Thr Gly 
545                 550                 555                 560 


Phe Leu Lys Thr Cys Gly Ala Pro Pro Cys Asn Ile Tyr Gly Gly Gly 
                565                 570                 575     


Gly Asn Pro Asn Asn Glu Ser His Leu Phe Cys Pro Thr Asp Cys Phe 
            580                 585                 590         


Arg Lys His Pro Asp Ala Thr Tyr Ser Arg Cys Gly Ala Gly Pro Trp 
        595                 600                 605             


Leu Thr Pro Arg Cys Met Val Asp Tyr Pro Tyr Arg Leu Trp His Tyr 
    610                 615                 620                 


Pro Cys Thr Val Asn Phe Thr Leu Phe Lys Val Arg Met Phe Val Gly 
625                 630                 635                 640 


Gly Phe Glu His Arg Phe Thr Ala Ala Cys Asn Trp Thr Arg Gly Glu 
                645                 650                 655     


Arg Cys Asn Ile Glu Asp Arg Asp Arg Ser Glu Gln His Pro Leu Leu 
            660                 665                 670         


His Ser Thr Thr Glu Leu Ala Ile Leu Pro Cys Ser Phe Thr Pro Met 
        675                 680                 685             


Pro Ala Leu Ser Thr Gly Leu Ile His Leu His Gln Asn Ile Val Asp 
    690                 695                 700                 


Val Gln Tyr Leu Tyr Gly Val Gly Ser Gly Met Val Gly Trp Ala Leu 
705                 710                 715                 720 


Lys Trp Glu Phe Val Ile Leu Ile Phe Leu Leu Leu Ala Asp Ala Arg 
                725                 730                 735     


Val Cys Val Ala Leu Trp Leu Met Leu Met Ile Ser Gln Ala Glu Ala 
            740                 745                 750         


<210>  48
<211>  752
<212>  PRT
<213>  Hepatitis C virus

<400>  48

Met Ser Thr Leu Pro Lys Pro Gln Arg Lys Thr Lys Arg Asn Thr Ile 
1               5                   10                  15      


Arg Arg Pro Gln Asp Val Lys Phe Pro Gly Gly Gly Gln Ile Val Gly 
            20                  25                  30          


Gly Val Tyr Val Leu Pro Arg Arg Gly Pro Arg Leu Gly Val Cys Ala 
        35                  40                  45              


Thr Arg Lys Thr Ser Glu Arg Ser Gln Pro Arg Arg Arg Arg Gln Pro 
    50                  55                  60                  


Ile Pro Lys Ala Arg Gln Ser Gly Gly Arg Ser Trp Ala Gln Pro Gly 
65                  70                  75                  80  


Tyr Pro Trp Pro Leu Tyr Gly Asn Glu Gly Cys Gly Trp Ala Gly Trp 
                85                  90                  95      


Leu Leu Ser Pro Arg Gly Ser Arg Pro Ser Trp Gly Pro Asn Asp Pro 
            100                 105                 110         


Arg Arg Arg Ser Arg Asn Leu Gly Lys Val Ile Asp Thr Leu Thr Cys 
        115                 120                 125             


Gly Phe Ala Asp Leu Met Gly Tyr Ile Pro Leu Val Gly Ala Pro Val 
    130                 135                 140                 


Gly Gly Val Ala Arg Ala Leu Ala His Gly Val Arg Ala Leu Glu Asp 
145                 150                 155                 160 


Gly Ile Asn Phe Ala Thr Gly Asn Leu Pro Gly Cys Ser Phe Ser Ile 
                165                 170                 175     


Phe Leu Leu Ala Leu Phe Ser Cys Leu Ile His Pro Ala Ala Ser Leu 
            180                 185                 190         


Glu Trp Arg Asn Thr Ser Gly Leu Tyr Val Leu Thr Asn Asp Cys Ser 
        195                 200                 205             


Asn Ser Ser Ile Val Tyr Glu Ala Asp Asp Val Ile Leu His Thr Pro 
    210                 215                 220                 


Gly Cys Val Pro Cys Val Gln Asn Asp Asn Ile Ser Thr Cys Trp Thr 
225                 230                 235                 240 


Pro Val Thr Pro Thr Val Ala Val Arg Tyr Val Gly Ala Thr Thr Ala 
                245                 250                 255     


Ser Ile Arg Ser His Val Asp Leu Leu Val Gly Ala Ala Thr Met Cys 
            260                 265                 270         


Ser Ala Leu Tyr Val Gly Asp Met Cys Gly Ala Val Phe Leu Val Gly 
        275                 280                 285             


Gln Ala Phe Thr Phe Arg Pro Arg Arg His Gln Thr Val Gln Thr Cys 
    290                 295                 300                 


Asn Cys Ser Leu Tyr Pro Gly His Leu Ser Gly His Arg Met Ala Trp 
305                 310                 315                 320 


Asp Met Met Met Asn Trp Phe Pro Ala Leu Gly Met Ala Val Ala His 
                325                 330                 335     


Val Leu Arg Val Pro Gln Thr Leu Phe Asp Ile Ile Ala Gly Ala His 
            340                 345                 350         


Trp Gly Ile Leu Ala Gly Leu Ala Tyr Tyr Ser Met Gln Gly Asn Trp 
        355                 360                 365             


Ala Lys Val Ala Ile Ile Met Val Met Phe Ser Gly Val Asp Ala Val 
    370                 375                 380                 


Thr Tyr Thr Thr Gly Gly Ser Ala Ala His Ala Thr Arg Gly Leu Thr 
385                 390                 395                 400 


Ser Leu Phe Ser Val Gly Ala Gln Gln Lys Leu Gln Leu Val Asn Thr 
                405                 410                 415     


Asn Gly Ser Trp His Ile Asn Ser Thr Ala Leu Asn Cys Asn Glu Ser 
            420                 425                 430         


Ile Asn Thr Gly Phe Ile Ala Gly Leu Phe Tyr Tyr His Arg Phe Asn 
        435                 440                 445             


Ser Thr Gly Cys Pro Gln Arg Leu Ser Ser Cys Lys Pro Ile Thr Phe 
    450                 455                 460                 


Phe Lys Gln Gly Trp Gly Pro Leu Thr Asp Ala Asn Ile Ser Gly Pro 
465                 470                 475                 480 


Ser Asp Asp Lys Pro Tyr Cys Trp His Tyr Ala Pro Arg Pro Cys Lys 
                485                 490                 495     


Val Val Pro Ala Ser Gly Val Cys Gly Pro Val Tyr Cys Phe Thr Pro 
            500                 505                 510         


Ser Pro Val Val Val Gly Thr Thr Asp Ala Lys Gly Val Pro Thr Tyr 
        515                 520                 525             


Thr Trp Gly Ala Asn Asp Thr Asp Val Phe Leu Leu Glu Ser Leu Arg 
    530                 535                 540                 


Pro Pro Gly Gly Arg Trp Phe Gly Cys Thr Trp Met Asn Ser Thr Gly 
545                 550                 555                 560 


Phe Val Lys Thr Cys Gly Ala Ser Pro Cys Asp Ile Tyr Gly Gly Gly 
                565                 570                 575     


Gly Asn Ser Gly Asn Glu Ser Asp Leu Phe Cys Pro Thr Asp Cys Phe 
            580                 585                 590         


Arg Lys His Pro Glu Ala Thr Tyr Ser Arg Cys Gly Ala Gly Pro Trp 
        595                 600                 605             


Leu Thr Pro Arg Cys Met Val Asp Tyr Pro Tyr Arg Leu Trp His Tyr 
    610                 615                 620                 


Pro Cys Thr Val Asn Phe Thr Leu Phe Lys Val Arg Met Phe Val Gly 
625                 630                 635                 640 


Gly Phe Glu His Arg Phe Thr Ala Ala Cys Asn Trp Thr Arg Gly Glu 
                645                 650                 655     


Arg Cys Asp Ile Glu Asp Arg Asp Arg Ser Glu Gln His Pro Leu Leu 
            660                 665                 670         


His Ser Thr Thr Glu Leu Ala Ile Leu Pro Cys Ser Phe Thr Pro Met 
        675                 680                 685             


Pro Ala Leu Ser Thr Gly Leu Ile His Leu His Gln Asn Ile Val Asp 
    690                 695                 700                 


Val Gln Tyr Leu Tyr Gly Val Gly Ser Gly Met Val Gly Trp Ala Leu 
705                 710                 715                 720 


Lys Trp Glu Phe Val Ile Leu Ile Phe Leu Leu Leu Ala Asp Arg Arg 
                725                 730                 735     


Val Cys Val Ala Leu Trp Leu Met Leu Met Ile Thr Gln Ala Glu Ala 
            740                 745                 750         


<210>  49
<211>  752
<212>  PRT
<213>  Hepatitis C virus

<400>  49

Met Ser Thr Leu Pro Lys Pro Gln Arg Lys Thr Lys Arg Asn Thr Val 
1               5                   10                  15      


Cys Arg Pro Gln Asp Val Lys Phe Pro Gly Gly Gly Gln Ile Val Gly 
            20                  25                  30          


Gly Val Tyr Val Leu Pro Arg Arg Gly Pro Arg Leu Gly Val Arg Ala 
        35                  40                  45              


Thr Arg Lys Thr Ser Glu Arg Ser Gln Pro Arg Gly Arg Arg Gln Pro 
    50                  55                  60                  


Ile Pro Lys Ala Arg Arg Ser Glu Gly Arg Ser Trp Ala Gln Pro Gly 
65                  70                  75                  80  


Tyr Pro Trp Pro Leu Tyr Gly Asn Glu Gly Cys Gly Trp Ala Gly Trp 
                85                  90                  95      


Leu Leu Ser Pro Arg Gly Ser Arg Pro Ser Trp Gly Pro Asn Asp Pro 
            100                 105                 110         


Arg Arg Arg Ser Arg Asn Leu Gly Lys Val Ile Asp Thr Leu Thr Cys 
        115                 120                 125             


Gly Phe Ala Asp Leu Met Gly Tyr Ile Pro Leu Val Gly Ala Pro Val 
    130                 135                 140                 


Gly Gly Val Ala Arg Ala Leu Ala His Gly Val Arg Ala Leu Glu Asp 
145                 150                 155                 160 


Gly Ile Asn Phe Ala Thr Gly Asn Leu Pro Gly Cys Ser Phe Ser Ile 
                165                 170                 175     


Phe Leu Leu Ala Leu Phe Ser Cys Leu Ile His Pro Ala Ala Ser Leu 
            180                 185                 190         


Glu Trp Arg Asn Val Ser Gly Leu Tyr Ile Leu Thr Asn Asp Cys Pro 
        195                 200                 205             


Asn Ser Ser Ile Val Tyr Glu Ala Asp Asp Val Ile Leu His Thr Pro 
    210                 215                 220                 


Gly Cys Ile Pro Cys Val Gln Asp Gly Asn Thr Ser Thr Cys Trp Thr 
225                 230                 235                 240 


Ala Leu Thr Pro Thr Val Ala Val Arg Tyr Val Gly Ala Thr Thr Ala 
                245                 250                 255     


Ser Ile Arg Ser His Val Asp Leu Leu Val Gly Ala Ala Thr Met Cys 
            260                 265                 270         


Ser Ala Leu Tyr Val Gly Asp Met Cys Gly Ala Val Phe Leu Val Gly 
        275                 280                 285             


Gln Ala Phe Thr Phe Arg Pro Arg Arg His Gln Thr Val Gln Thr Cys 
    290                 295                 300                 


Asn Cys Ser Leu Tyr Pro Gly His Leu Thr Gly His Arg Met Ala Trp 
305                 310                 315                 320 


Asp Met Met Met Asn Trp Ser Pro Ala Val Gly Met Val Val Ala His 
                325                 330                 335     


Val Leu Arg Leu Pro Gln Thr Leu Phe Asp Ile Ile Ala Gly Ala His 
            340                 345                 350         


Trp Gly Ile Leu Ala Gly Leu Ala Tyr Tyr Ser Met Gln Gly Asn Trp 
        355                 360                 365             


Ala Lys Val Ile Ile Ile Met Val Met Phe Ser Gly Val Asp Ala Thr 
    370                 375                 380                 


Thr His Val Thr Gly Gly Thr Ala Gly Leu Thr Ala Phe Arg Leu Thr 
385                 390                 395                 400 


Gly Leu Phe Thr Val Gly Pro Gln Gln Lys Leu Gln Leu Val Asn Thr 
                405                 410                 415     


Asn Gly Ser Trp His Ile Asn Arg Thr Ala Leu Asn Cys Asn Asp Ser 
            420                 425                 430         


Leu Asn Thr Gly Phe Ile Ala Gly Leu Phe Arg Phe His Lys Phe Asn 
        435                 440                 445             


Ser Thr Gly Cys Pro Glu Met Leu Ser Ser Cys Lys Pro Ile Thr Ser 
    450                 455                 460                 


Phe Lys Gln Gly Trp Gly Pro Leu Thr Asp Ala Asn Ile Thr Ile Pro 
465                 470                 475                 480 


Ser Asp Asp Arg Pro Tyr Cys Trp His Tyr Pro Pro Arg Ser Cys Glu 
                485                 490                 495     


Val Val Pro Ala Leu Ser Val Cys Gly Pro Val Tyr Cys Phe Thr Pro 
            500                 505                 510         


Ser Pro Val Val Val Gly Thr Thr Asp Ala Lys Gly Val Pro Thr Tyr 
        515                 520                 525             


Thr Trp Gly Glu Asn Glu Thr Asp Val Phe Leu Leu Lys Ser Leu Arg 
    530                 535                 540                 


Pro Pro Gly Gly Arg Trp Phe Gly Cys Thr Trp Met Asn Ser Thr Gly 
545                 550                 555                 560 


Phe Val Gln Thr Cys Gly Ala Pro Pro Cys Asn Ile Tyr Gly Gly Gly 
                565                 570                 575     


Gly Asp Leu Lys Asn Glu Ser Asp Leu Phe Cys Pro Thr Asp Cys Phe 
            580                 585                 590         


Arg Lys His Pro Glu Ala Thr Tyr Ser Arg Cys Gly Ala Gly Pro Trp 
        595                 600                 605             


Leu Thr Pro Arg Cys Met Val Asp Tyr Pro Tyr Arg Leu Trp His Tyr 
    610                 615                 620                 


Pro Cys Thr Val Asn Phe Thr Leu Phe Lys Val Arg Met Phe Val Gly 
625                 630                 635                 640 


Gly Phe Glu His Arg Phe Thr Ala Ala Cys Asn Trp Thr Arg Gly Glu 
                645                 650                 655     


Arg Cys Asp Ile Glu Asp Arg Asp Arg Ser Glu Leu His Pro Leu Leu 
            660                 665                 670         


His Ser Thr Thr Glu Leu Ala Ile Leu Pro Cys Ser Phe Thr Pro Met 
        675                 680                 685             


Pro Ala Leu Ser Thr Gly Leu Ile His Leu His Gln Asn Ile Val Asp 
    690                 695                 700                 


Val Gln Tyr Leu Tyr Gly Val Gly Ser Gly Met Val Gly Trp Ala Val 
705                 710                 715                 720 


Lys Trp Glu Phe Val Ile Leu Val Phe Leu Leu Leu Ala Asp Ala Arg 
                725                 730                 735     


Val Cys Val Ala Leu Trp Leu Met Leu Met Ile Ser Gln Ala Glu Ala 
            740                 745                 750         


<210>  50
<211>  752
<212>  PRT
<213>  Hepatitis C virus

<400>  50

Met Ser Thr Leu Pro Lys Pro Gln Arg Lys Thr Lys Arg Asn Thr Ile 
1               5                   10                  15      


Arg Arg Pro Gln Asp Val Lys Phe Pro Gly Gly Gly Gln Ile Val Gly 
            20                  25                  30          


Gly Val Tyr Val Leu Pro Arg Arg Gly Pro Arg Leu Gly Val Arg Ala 
        35                  40                  45              


Thr Arg Lys Thr Ser Glu Arg Ser Gln Pro Arg Gly Arg Arg Gln Pro 
    50                  55                  60                  


Ile Pro Lys Ala Arg Arg Ser Glu Gly Arg Ser Trp Ala Gln Pro Gly 
65                  70                  75                  80  


Tyr Pro Trp Pro Leu Tyr Gly Asn Glu Gly Cys Gly Trp Ala Gly Trp 
                85                  90                  95      


Leu Leu Ser Pro Arg Gly Ser Arg Pro Ser Trp Gly Pro Asn Asp Pro 
            100                 105                 110         


Arg Arg Arg Ser Arg Asn Leu Gly Lys Val Ile Asp Thr Leu Thr Cys 
        115                 120                 125             


Gly Phe Ala Asp Leu Met Gly Tyr Ile Pro Leu Val Gly Ala Pro Val 
    130                 135                 140                 


Gly Gly Val Ala Arg Ala Leu Ala His Gly Val Arg Ala Leu Glu Asp 
145                 150                 155                 160 


Gly Ile Asn Phe Ala Thr Gly Asn Leu Pro Gly Cys Ser Phe Ser Ile 
                165                 170                 175     


Phe Leu Leu Ala Leu Phe Ser Cys Leu Ile His Pro Ala Ala Ser Leu 
            180                 185                 190         


Gln Trp Arg Asn Thr Ser Gly Leu Tyr Val Leu Thr Asn Asp Cys Ser 
        195                 200                 205             


Asn Ser Ser Ile Val Tyr Glu Ala Asp Asp Val Ile Leu His Thr Pro 
    210                 215                 220                 


Gly Cys Val Pro Cys Val Gln Asp Gly Asn Thr Ser Thr Cys Trp Thr 
225                 230                 235                 240 


Pro Val Thr Pro Thr Val Ala Val Arg Tyr Val Gly Ala Thr Thr Ala 
                245                 250                 255     


Ser Ile Arg Ser His Val Asp Leu Leu Val Gly Ala Ala Thr Met Cys 
            260                 265                 270         


Ser Ala Leu Tyr Val Gly Asp Met Cys Gly Ala Val Phe Leu Val Gly 
        275                 280                 285             


Gln Ala Phe Thr Phe Arg Pro Arg Arg His Gln Thr Val Gln Thr Cys 
    290                 295                 300                 


Asn Cys Ser Leu Tyr Pro Gly His Leu Ser Gly His Arg Met Ala Trp 
305                 310                 315                 320 


Asp Met Met Met Asn Trp Ser Pro Ala Ala Gly Met Val Val Ala His 
                325                 330                 335     


Ile Leu Arg Leu Pro Gln Thr Leu Phe Asp Ile Ile Ala Gly Ala His 
            340                 345                 350         


Trp Gly Ile Leu Ala Gly Leu Ala Tyr Tyr Ser Met Gln Gly Asn Trp 
        355                 360                 365             


Ala Lys Val Ala Ile Ile Met Val Met Phe Ser Gly Val Asp Ala Thr 
    370                 375                 380                 


Thr Tyr Thr Ser Gly Gly Ser Val Ala Gln Gln Ala Arg Gly Leu Ala 
385                 390                 395                 400 


Asp Leu Phe Ser Val Gly Ala Lys Gln Asn Leu Gln Leu Val Asn Thr 
                405                 410                 415     


Asn Gly Ser Trp His Ile Asn Ser Thr Ala Leu Asn Cys Asp Asp Ser 
            420                 425                 430         


Ile Asn Thr Gly Phe Ile Ala Gly Leu Phe Tyr Tyr His Lys Phe Asn 
        435                 440                 445             


Ser Thr Gly Cys Pro Gln Arg Leu Ser Asp Cys Lys Pro Ile Thr Phe 
    450                 455                 460                 


Phe Lys Gln Gly Trp Gly Pro Leu Thr Asp Ala Asn Ile Thr Gly Pro 
465                 470                 475                 480 


Ser Asp Asp Lys Pro Tyr Cys Trp His Tyr Ala Pro Arg Arg Cys Gly 
                485                 490                 495     


Val Val Pro Ala Ser Ser Val Cys Gly Pro Val Tyr Cys Phe Thr Pro 
            500                 505                 510         


Ser Pro Val Val Val Gly Thr Thr Asp Ala Lys Gly Val Pro Thr Tyr 
        515                 520                 525             


Thr Trp Gly Ala Asn Glu Thr Asp Val Phe Leu Leu Glu Ser Leu Arg 
    530                 535                 540                 


Pro Pro Ser Gly Arg Trp Phe Gly Cys Ala Trp Met Asn Ser Thr Gly 
545                 550                 555                 560 


Phe Leu Lys Thr Cys Gly Ala Pro Pro Cys Asn Ile Tyr Gly Gly Gly 
                565                 570                 575     


Gly Asn Pro His Asn Glu Ser Asp Leu Phe Cys Pro Thr Asp Cys Phe 
            580                 585                 590         


Arg Lys His Pro Glu Ala Thr Tyr Ser Arg Cys Gly Ala Gly Pro Trp 
        595                 600                 605             


Leu Thr Pro Arg Cys Met Val Asp Tyr Pro Tyr Arg Leu Trp His Tyr 
    610                 615                 620                 


Pro Cys Thr Val Asn Phe Thr Leu Phe Lys Met Arg Thr Phe Val Gly 
625                 630                 635                 640 


Gly Phe Glu His Arg Phe Thr Ala Ala Cys Asn Trp Thr Arg Gly Glu 
                645                 650                 655     


Arg Cys Asp Ile Glu Asp Arg Asp Arg Ser Glu Gln His Pro Leu Leu 
            660                 665                 670         


His Ser Thr Thr Glu Leu Ala Ile Leu Pro Cys Ser Phe Thr Pro Met 
        675                 680                 685             


Pro Ala Leu Ser Thr Gly Leu Ile His Leu His Gln Asn Ile Val Asp 
    690                 695                 700                 


Val Gln Tyr Leu Tyr Gly Val Gly Ser Gly Met Val Gly Trp Ala Leu 
705                 710                 715                 720 


Lys Trp Glu Phe Val Ile Leu Val Phe Leu Leu Leu Ala Asp Ala Arg 
                725                 730                 735     


Val Cys Val Ala Leu Trp Leu Met Leu Met Ile Ser Gln Ala Glu Ala 
            740                 745                 750         


<210>  51
<211>  752
<212>  PRT
<213>  Hepatitis C virus

<400>  51

Met Ser Thr Leu Pro Lys Pro Gln Arg Lys Thr Lys Arg Asn Thr Ile 
1               5                   10                  15      


Arg Arg Pro Gln Asp Val Lys Phe Pro Gly Gly Gly Gln Ile Val Gly 
            20                  25                  30          


Gly Val Tyr Val Leu Pro Arg Arg Gly Pro Arg Leu Gly Val Arg Ala 
        35                  40                  45              


Thr Arg Lys Thr Ser Glu Arg Ser Gln Pro Arg Gly Arg Arg Gln Pro 
    50                  55                  60                  


Ile Pro Lys Ala Arg Arg Ser Glu Gly Arg Ser Trp Ala Gln Pro Gly 
65                  70                  75                  80  


Tyr Pro Trp Pro Leu Tyr Gly Asn Glu Gly Cys Gly Trp Ala Gly Trp 
                85                  90                  95      


Leu Leu Ser Pro Arg Gly Ser Arg Pro Ser Trp Gly Pro Asn Asp Pro 
            100                 105                 110         


Arg Arg Arg Ser Arg Asn Leu Gly Lys Val Ile Asp Thr Leu Thr Cys 
        115                 120                 125             


Gly Phe Ala Asp Leu Met Gly Tyr Ile Pro Leu Val Gly Ala Pro Val 
    130                 135                 140                 


Gly Gly Val Ala Arg Ala Leu Ala His Gly Val Arg Ala Leu Glu Asp 
145                 150                 155                 160 


Gly Ile Asn Phe Ala Thr Gly Asn Leu Pro Gly Cys Ser Phe Ser Ile 
                165                 170                 175     


Phe Leu Leu Ala Leu Phe Ser Cys Leu Ile His Pro Ala Ala Ser Leu 
            180                 185                 190         


Gln Trp Arg Asn Thr Ser Gly Leu Tyr Val Leu Thr Asn Asp Cys Ser 
        195                 200                 205             


Asn Ser Ser Ile Val Tyr Glu Ala Asp Asp Val Ile Leu His Thr Pro 
    210                 215                 220                 


Gly Cys Val Pro Cys Val Gln Asp Gly Asn Thr Ser Thr Cys Trp Thr 
225                 230                 235                 240 


Pro Val Thr Pro Thr Val Ala Val Arg Tyr Val Gly Ala Thr Thr Ala 
                245                 250                 255     


Ser Ile Arg Ser His Val Asp Leu Leu Val Gly Ala Ala Thr Met Cys 
            260                 265                 270         


Ser Ala Leu Tyr Val Gly Asp Met Cys Gly Ala Val Phe Leu Val Gly 
        275                 280                 285             


Gln Ala Phe Thr Phe Arg Pro Arg Arg His Gln Thr Val Gln Thr Cys 
    290                 295                 300                 


Asn Cys Ser Leu Tyr Pro Gly His Leu Ser Gly His Arg Met Ala Trp 
305                 310                 315                 320 


Asp Met Met Met Asn Trp Ser Pro Ala Ala Gly Met Val Val Ala His 
                325                 330                 335     


Ile Leu Arg Leu Pro Gln Thr Leu Phe Asp Ile Ile Ala Gly Ala His 
            340                 345                 350         


Trp Gly Ile Leu Ala Gly Leu Ala Tyr Tyr Ser Met Gln Gly Asn Trp 
        355                 360                 365             


Ala Lys Val Ala Ile Ile Met Val Met Phe Ser Gly Val Asp Ala Thr 
    370                 375                 380                 


Thr Tyr Thr Ser Gly Gly Ser Val Ala Gln Gln Ala Arg Gly Leu Ala 
385                 390                 395                 400 


Asp Leu Phe Ser Val Gly Ala Lys Gln Asn Leu Gln Leu Val Asn Thr 
                405                 410                 415     


Asn Gly Ser Trp His Ile Asn Ser Thr Ala Leu Asn Cys Asp Asp Ser 
            420                 425                 430         


Ile Asn Thr Gly Phe Ile Ala Gly Leu Phe Tyr Tyr His Lys Phe Asn 
        435                 440                 445             


Ser Thr Gly Cys Pro Gln Arg Leu Ser Asp Cys Lys Pro Ile Thr Phe 
    450                 455                 460                 


Phe Lys Gln Gly Trp Gly Pro Leu Thr Asp Ala Asn Ile Thr Gly Pro 
465                 470                 475                 480 


Ser Asp Asp Lys Pro Tyr Cys Trp His Tyr Ala Pro Arg Arg Cys Gly 
                485                 490                 495     


Val Val Pro Ala Ser Ser Val Cys Gly Pro Val Tyr Cys Phe Thr Pro 
            500                 505                 510         


Ser Pro Val Val Val Gly Thr Thr Asp Ala Lys Gly Val Pro Thr Tyr 
        515                 520                 525             


Thr Trp Gly Ala Asn Glu Thr Asp Val Phe Leu Leu Glu Ser Leu Arg 
    530                 535                 540                 


Pro Pro Ser Gly Arg Trp Phe Gly Cys Ala Trp Met Asn Ser Thr Gly 
545                 550                 555                 560 


Phe Leu Lys Thr Cys Gly Ala Pro Pro Cys Asn Ile Tyr Gly Gly Gly 
                565                 570                 575     


Gly Asn Pro His Asn Glu Ser Asp Leu Phe Cys Pro Thr Asp Cys Phe 
            580                 585                 590         


Arg Lys His Pro Glu Ala Thr Tyr Ser Arg Cys Gly Ala Gly Pro Trp 
        595                 600                 605             


Leu Thr Pro Arg Cys Met Val Asp Tyr Pro Tyr Arg Leu Trp His Tyr 
    610                 615                 620                 


Pro Cys Thr Val Asn Phe Thr Leu Phe Lys Met Arg Thr Phe Val Gly 
625                 630                 635                 640 


Gly Phe Glu His Arg Phe Thr Ala Ala Cys Asn Trp Thr Arg Gly Glu 
                645                 650                 655     


Arg Cys Asp Ile Glu Asp Arg Asp Arg Ser Glu Gln His Pro Leu Leu 
            660                 665                 670         


His Ser Thr Thr Glu Leu Ala Ile Leu Pro Cys Ser Phe Thr Pro Met 
        675                 680                 685             


Pro Ala Leu Ser Thr Gly Leu Ile His Leu His Gln Asn Ile Val Asp 
    690                 695                 700                 


Val Gln Tyr Leu Tyr Gly Val Gly Ser Gly Met Val Gly Trp Ala Leu 
705                 710                 715                 720 


Lys Trp Glu Phe Val Ile Leu Val Phe Leu Leu Leu Ala Asp Ala Arg 
                725                 730                 735     


Val Cys Val Ala Leu Trp Leu Met Leu Met Ile Ser Gln Ala Glu Ala 
            740                 745                 750         


<210>  52
<211>  752
<212>  PRT
<213>  Hepatitis C virus

<400>  52

Met Ser Thr Leu Pro Lys Pro Gln Arg Lys Thr Lys Arg Asn Thr Ile 
1               5                   10                  15      


Arg Arg Pro Gln Asp Val Lys Phe Pro Gly Gly Gly Gln Ile Val Gly 
            20                  25                  30          


Gly Val Tyr Val Leu Pro Arg Arg Gly Pro Arg Leu Gly Val Cys Ala 
        35                  40                  45              


Thr Arg Lys Thr Ser Glu Arg Ser Gln Pro Arg Gly Arg Arg Gln Pro 
    50                  55                  60                  


Ile Pro Lys Ala Arg Arg Ser Glu Gly Arg Ser Trp Ala Gln Pro Gly 
65                  70                  75                  80  


Tyr Pro Trp Pro Leu Tyr Gly Asn Glu Gly Cys Gly Trp Ala Gly Trp 
                85                  90                  95      


Leu Leu Ser Pro Arg Gly Ser Arg Pro Ser Trp Gly Pro Asn Asp Pro 
            100                 105                 110         


Arg Arg Arg Ser Arg Asn Leu Gly Lys Val Ile Asp Thr Leu Thr Cys 
        115                 120                 125             


Gly Phe Ala Asp Leu Met Gly Tyr Ile Pro Leu Val Gly Ala Pro Val 
    130                 135                 140                 


Gly Gly Val Ala Arg Ala Leu Ala His Gly Val Arg Ala Leu Glu Asp 
145                 150                 155                 160 


Gly Ile Asn Phe Ala Thr Gly Asn Leu Pro Gly Cys Ser Phe Ser Ile 
                165                 170                 175     


Phe Leu Leu Ala Leu Phe Ser Cys Leu Val His Pro Ala Ala Ser Leu 
            180                 185                 190         


Glu Trp Arg Asn Thr Ser Gly Leu Tyr Val Leu Thr Asn Asp Cys Pro 
        195                 200                 205             


Asn Ser Ser Ile Val Tyr Glu Ala Asp Asp Val Ile Leu His Thr Pro 
    210                 215                 220                 


Gly Cys Ile Pro Cys Val Gln Asp Gly Asn Lys Ser Thr Cys Trp Thr 
225                 230                 235                 240 


Ser Val Thr Pro Thr Val Ala Val Lys Tyr Val Gly Ala Thr Thr Ala 
                245                 250                 255     


Ser Ile Arg Ser His Val Asp Leu Leu Val Gly Ala Ala Thr Met Cys 
            260                 265                 270         


Ser Ala Leu Tyr Val Gly Asp Met Cys Gly Ala Val Phe Leu Val Gly 
        275                 280                 285             


Gln Ala Phe Thr Phe Arg Pro Arg Arg His Gln Thr Val Gln Thr Cys 
    290                 295                 300                 


Asn Cys Ser Leu Tyr Pro Gly His Leu Ser Gly His Arg Met Ala Trp 
305                 310                 315                 320 


Asp Met Met Met Asn Trp Ser Pro Ala Val Gly Met Val Val Ala His 
                325                 330                 335     


Val Leu Arg Leu Pro Gln Thr Leu Phe Asp Ile Ile Ala Gly Ala His 
            340                 345                 350         


Trp Gly Ile Leu Ala Gly Leu Ala Tyr Tyr Ser Met Gln Gly Asn Trp 
        355                 360                 365             


Ala Lys Val Ala Ile Ile Met Val Met Phe Ser Gly Val Asp Ala Thr 
    370                 375                 380                 


Thr Tyr Thr Thr Gly Gly Asn Ala Ala Arg Gly Ala Ser Gly Ile Val 
385                 390                 395                 400 


Ser Leu Phe Thr Pro Gly Ala Lys Gln Asn Leu Gln Leu Val Asn Thr 
                405                 410                 415     


Asn Gly Ser Trp His Ile Asn Arg Thr Ala Leu Asn Cys Asn Asp Ser 
            420                 425                 430         


Ile Asn Thr Gly Phe Ile Ala Gly Leu Ile Tyr Tyr His Lys Phe Asn 
        435                 440                 445             


Ser Thr Gly Cys Pro Gln Arg Leu Ser Ser Cys Lys Pro Ile Thr Phe 
    450                 455                 460                 


Phe Arg Gln Gly Trp Gly Ser Leu Thr Asp Ala Asn Ile Thr Gly Pro 
465                 470                 475                 480 


Ser Asp Asp Lys Pro Tyr Cys Trp His Tyr Pro Pro Arg Pro Cys Asp 
                485                 490                 495     


Thr Ile Arg Ala Ser Ser Val Cys Gly Pro Val Tyr Cys Phe Thr Pro 
            500                 505                 510         


Ser Pro Val Val Val Gly Thr Thr Asp Ala Lys Gly Ala Pro Thr Tyr 
        515                 520                 525             


Asn Trp Gly Ala Asn Glu Thr Asp Met Phe Leu Leu Gln Ser Leu Arg 
    530                 535                 540                 


Pro Pro Ser Gly Arg Trp Phe Gly Cys Thr Trp Met Asn Ser Thr Gly 
545                 550                 555                 560 


Phe Thr Lys Thr Cys Gly Ala Pro Pro Cys Asn Ile Tyr Gly Gly Gly 
                565                 570                 575     


Gly Asn Leu Asn Asn Glu Ser Asp Leu Phe Cys Pro Thr Asp Cys Phe 
            580                 585                 590         


Arg Lys His Pro Glu Ala Thr Tyr Ser Arg Cys Gly Ala Gly Pro Trp 
        595                 600                 605             


Leu Thr Pro Arg Cys Leu Val Asp Tyr Pro Tyr Arg Leu Trp His Tyr 
    610                 615                 620                 


Pro Cys Thr Val Asn Phe Thr Leu Phe Arg Met Arg Thr Phe Val Gly 
625                 630                 635                 640 


Gly Phe Glu His Arg Phe Thr Ala Ala Cys Asn Trp Thr Arg Gly Glu 
                645                 650                 655     


Arg Cys Asn Ile Glu Asp Arg Asp Arg Ser Glu Gln His Pro Leu Leu 
            660                 665                 670         


His Ser Thr Thr Glu Leu Ala Ile Leu Pro Cys Ser Phe Thr Pro Met 
        675                 680                 685             


Pro Ala Leu Ser Thr Gly Leu Ile His Leu His Gln Asn Ile Val Asp 
    690                 695                 700                 


Val Gln Tyr Leu Tyr Gly Ile Gly Ser Gly Val Val Gly Trp Ala Leu 
705                 710                 715                 720 


Lys Trp Glu Phe Val Ile Leu Val Phe Leu Leu Leu Ala Asp Ala Arg 
                725                 730                 735     


Val Cys Val Ala Leu Trp Leu Met Leu Met Ile Ser Gln Ala Glu Ala 
            740                 745                 750         


<210>  53
<211>  752
<212>  PRT
<213>  Hepatitis C virus

<400>  53

Met Ser Thr Leu Pro Lys Pro Gln Arg Lys Thr Lys Arg Asn Thr Ile 
1               5                   10                  15      


Arg Arg Pro Gln Asp Val Lys Phe Pro Gly Gly Gly Val Ile Tyr Val 
            20                  25                  30          


Gly Val Tyr Val Leu Pro Arg Arg Gly Pro Arg Leu Gly Val Arg Ala 
        35                  40                  45              


Thr Arg Lys Thr Ser Glu Arg Ser Gln Pro Arg Gly Arg Arg Lys Pro 
    50                  55                  60                  


Ile Pro Lys Ala Arg Arg Ser Glu Gly Arg Ser Trp Ala Gln Pro Gly 
65                  70                  75                  80  


Tyr Pro Trp Pro Leu Tyr Gly Asn Glu Gly Cys Gly Trp Ala Gly Trp 
                85                  90                  95      


Leu Leu Ser Pro Arg Gly Ser Arg Pro Asn Trp Ala Pro Asn Asp Pro 
            100                 105                 110         


Arg Arg Arg Ser Arg Asn Leu Gly Lys Val Ile Asp Thr Leu Thr Cys 
        115                 120                 125             


Gly Phe Ala Asp Leu Met Gly Tyr Ile Pro Leu Val Gly Ala Pro Leu 
    130                 135                 140                 


Gly Gly Ala Ala Arg Ala Leu Ala His Gly Val Arg Ala Leu Glu Asp 
145                 150                 155                 160 


Gly Ile Asn Phe Ala Thr Gly Asn Leu Pro Gly Cys Ser Phe Ser Ile 
                165                 170                 175     


Phe Leu Leu Ala Leu Phe Ser Cys Leu Ile His Pro Ala Ala Ser Leu 
            180                 185                 190         


Glu Trp Arg Asn Thr Ser Gly Leu Tyr Val Leu Thr Asn Asp Cys Ser 
        195                 200                 205             


Asn Ser Ser Ile Val Tyr Glu Ala Asp Asp Val Ile Leu His Thr Pro 
    210                 215                 220                 


Gly Cys Ile Pro Cys Val Gln Asp Gly Asn Thr Ser Thr Cys Trp Thr 
225                 230                 235                 240 


Pro Val Thr Pro Thr Val Ala Val Arg Tyr Val Gly Ala Thr Thr Ala 
                245                 250                 255     


Ser Ile Arg Ser His Val Asp Leu Leu Val Gly Ala Gly Thr Met Cys 
            260                 265                 270         


Ser Ala Leu Tyr Val Gly Asp Met Cys Gly Pro Val Phe Leu Val Gly 
        275                 280                 285             


Gln Ala Phe Thr Phe Arg Pro Arg Arg His Arg Thr Val Gln Thr Cys 
    290                 295                 300                 


Asn Cys Ser Leu Tyr Pro Gly His Leu Ser Gly Gln Arg Met Ala Trp 
305                 310                 315                 320 


Asp Met Met Met Asn Trp Ser Pro Ala Val Gly Met Val Val Ala His 
                325                 330                 335     


Ile Leu Arg Leu Pro Gln Thr Leu Phe Asp Val Val Ala Gly Ala His 
            340                 345                 350         


Trp Gly Ile Ile Ala Gly Leu Ala Tyr Tyr Ser Met Gln Gly Asn Trp 
        355                 360                 365             


Ala Lys Val Ala Ile Ile Met Val Met Phe Ser Gly Val Asp Ala Ser 
    370                 375                 380                 


Thr His Val Thr Ala Gly Gln Ala Ala Arg Asn Ala Tyr Gly Ile Thr 
385                 390                 395                 400 


Ser Leu Phe Ser Val Gly Ala Lys Gln Asn Leu Gln Leu Ile Asn Thr 
                405                 410                 415     


Asn Gly Ser Trp His Ile Asn Arg Thr Ala Leu Asn Cys Asn Glu Ser 
            420                 425                 430         


Ile Asn Thr Gly Phe Ile Ala Gly Leu Phe Tyr Tyr His Lys Phe Asn 
        435                 440                 445             


Ser Thr Gly Cys Pro Gln Arg Leu Ser Ser Cys Lys Pro Ile Thr Phe 
    450                 455                 460                 


Phe Lys Gln Gly Trp Gly Pro Leu Thr Asp Ala Asn Ile Thr Gly Pro 
465                 470                 475                 480 


Ser Asp Asp Lys Pro Tyr Cys Trp His Tyr Ala Pro Arg Pro Cys Gly 
                485                 490                 495     


Ile Val Pro Ala Leu Asn Val Cys Gly Pro Val Tyr Cys Phe Thr Pro 
            500                 505                 510         


Ser Pro Val Val Val Gly Thr Thr Asp Ala Lys Gly Ala Pro Thr Tyr 
        515                 520                 525             


Thr Trp Gly Ala Asn Lys Thr Asp Val Phe Leu Leu Glu Ser Leu Arg 
    530                 535                 540                 


Pro Pro Ser Gly Arg Trp Phe Gly Cys Thr Trp Met Asn Ser Thr Gly 
545                 550                 555                 560 


Phe Val Lys Thr Cys Gly Ala Pro Pro Cys Asn Ile Tyr Gly Asp Gly 
                565                 570                 575     


Arg Asp Ala Gln Asn Glu Ser Asp Leu Phe Cys Pro Thr Asp Cys Phe 
            580                 585                 590         


Arg Lys His Pro Glu Ala Thr Tyr Ser Arg Cys Gly Ala Gly Pro Trp 
        595                 600                 605             


Leu Thr Pro Arg Cys Leu Val Asp Tyr Pro Tyr Arg Leu Trp His Tyr 
    610                 615                 620                 


Pro Cys Thr Val Asn Phe Thr Leu Phe Lys Val Arg Met Phe Val Gly 
625                 630                 635                 640 


Gly Phe Glu His Arg Phe Thr Ala Ala Cys Asn Trp Thr Arg Gly Glu 
                645                 650                 655     


Arg Cys Asp Ile Glu Asp Arg Asp Arg Ser Glu Gln His Pro Leu Leu 
            660                 665                 670         


His Ser Thr Thr Glu Leu Ala Ile Leu Pro Cys Ser Phe Thr Pro Met 
        675                 680                 685             


Pro Ala Leu Ser Thr Gly Leu Ile His Leu His Gln Asn Ile Val Asp 
    690                 695                 700                 


Val Gln Tyr Leu Tyr Gly Ile Gly Ser Gly Met Val Gly Trp Ala Leu 
705                 710                 715                 720 


Lys Trp Glu Phe Val Ile Leu Ile Phe Leu Leu Leu Ala Asp Ala Arg 
                725                 730                 735     


Val Cys Val Ala Leu Trp Leu Ile Leu Thr Ile Ser Gln Ala Glu Ala 
            740                 745                 750         


<210>  54
<211>  754
<212>  PRT
<213>  Hepatitis C virus

<400>  54

Met Ser Thr Leu Pro Lys Pro Lys Arg Gln Thr Lys Arg Asn Thr Leu 
1               5                   10                  15      


Arg Arg Pro Lys Asn Val Lys Phe Pro Ala Gly Gly Gln Ile Val Gly 
            20                  25                  30          


Glu Val Tyr Val Leu Pro Arg Arg Gly Pro Gln Leu Gly Val Arg Glu 
        35                  40                  45              


Val Arg Lys Thr Ser Glu Arg Ser Gln Pro Arg Gly Arg Arg Gln Pro 
    50                  55                  60                  


Thr Pro Lys Ala Arg Pro Arg Glu Gly Arg Ser Trp Ala Gln Pro Gly 
65                  70                  75                  80  


Tyr Pro Trp Pro Leu Tyr Gly Asn Glu Gly Cys Gly Trp Ala Gly Trp 
                85                  90                  95      


Leu Leu Pro Pro Arg Gly Ser Arg Pro Ser Trp Gly Gln Asn Asp Pro 
            100                 105                 110         


Arg Arg Arg Ser Arg Asn Leu Gly Lys Val Ile Asp Thr Leu Thr Cys 
        115                 120                 125             


Gly Phe Ala Asp Leu Met Gly Tyr Ile Pro Leu Ile Gly Ala Pro Val 
    130                 135                 140                 


Gly Gly Val Ala Arg Ala Leu Ala His Gly Val Arg Ala Leu Glu Asp 
145                 150                 155                 160 


Gly Val Asn Tyr Ala Thr Gly Asn Leu Pro Gly Cys Ser Phe Ser Ile 
                165                 170                 175     


Phe Leu Leu Ala Leu Phe Ser Cys Leu Thr Cys Pro Ala Ser Ser Leu 
            180                 185                 190         


Glu Tyr Arg Asn Ala Ser Gly Leu Tyr Leu Leu Thr Asn Asp Cys Ser 
        195                 200                 205             


Asn Arg Ser Ile Val Tyr Glu Ala Asp Asp Val Ile Leu His Leu Pro 
    210                 215                 220                 


Gly Cys Val Pro Cys Val Glu Thr Asp Asn Asn Asn Thr Ser Cys Trp 
225                 230                 235                 240 


Thr Pro Ile Ser Pro Thr Val Ala Val Lys His Pro Gly Val Thr Thr 
                245                 250                 255     


Ala Ser Ile Arg Asn His Val Asn Met Leu Val Ala Pro Pro Thr Leu 
            260                 265                 270         


Cys Ser Ala Leu Tyr Val Glu Asp Ala Phe Gly Ala Val Ser Leu Val 
        275                 280                 285             


Gly Gln Ala Phe Thr Phe Arg Pro Arg Gln His Lys Thr Val Gln Thr 
    290                 295                 300                 


Cys Asn Cys Ser Ile Tyr Pro Gly His Val Ser Gly His Arg Met Ala 
305                 310                 315                 320 


Trp Asp Met Met Met Asn Trp Ser Pro Ala Ile Gly Leu Val Ile Ser 
                325                 330                 335     


His Leu Met Arg Leu Pro Gln Thr Phe Phe Asp Leu Val Val Gly Ala 
            340                 345                 350         


His Trp Gly Val Met Ala Gly Leu Ala Tyr Phe Ser Met Gln Gly Asn 
        355                 360                 365             


Trp Ala Lys Val Val Ile Val Leu Ile Met Phe Ser Gly Val Asp Ala 
    370                 375                 380                 


Thr Thr His Thr Thr Gly Gly Ser Ala Ala Gln Ala Thr Ala Gly Phe 
385                 390                 395                 400 


Thr Ser Phe Phe Thr Arg Gly Pro Ser Gln Asn Leu Gln Leu Val Asn 
                405                 410                 415     


Ser Asn Gly Ser Trp His Ile Asn Ser Thr Ala Leu Asn Cys Asn Asp 
            420                 425                 430         


Ser Leu Asn Thr Gly Phe Ile Ala Gly Leu Phe Tyr Tyr His Lys Phe 
        435                 440                 445             


Asn Ser Ser Gly Cys Pro Glu Arg Met Ser Ser Cys Lys Pro Ile Thr 
    450                 455                 460                 


Tyr Phe Asn Gln Gly Trp Gly Pro Leu Thr Asp Ala Asn Ile Asn Gly 
465                 470                 475                 480 


Pro Ser Glu Asp Arg Pro Tyr Cys Trp His Tyr Pro Pro Arg Pro Cys 
                485                 490                 495     


Asn Ile Thr Lys Pro Leu Asn Val Cys Gly Pro Val Tyr Cys Phe Thr 
            500                 505                 510         


Pro Ser Pro Val Val Val Gly Thr Thr Asp Ile Lys Gly Leu Pro Thr 
        515                 520                 525             


Tyr Arg Phe Gly Val Asn Glu Ser Asp Val Phe Leu Leu Thr Ser Leu 
    530                 535                 540                 


Arg Pro Pro Gln Gly Arg Trp Phe Gly Cys Val Trp Met Asn Ser Thr 
545                 550                 555                 560 


Gly Phe Val Lys Thr Cys Gly Ala Pro Pro Cys Asn Ile Tyr Gly Gly 
                565                 570                 575     


Met Lys Asp Ile Glu Ala Asn Gln Thr His Leu Lys Cys Pro Thr Asp 
            580                 585                 590         


Cys Phe Arg Lys His His Asp Ala Thr Phe Thr Arg Cys Gly Ser Gly 
        595                 600                 605             


Pro Trp Leu Thr Pro Arg Cys Leu Val Asp Tyr Pro Tyr Arg Leu Trp 
    610                 615                 620                 


His Tyr Pro Cys Thr Val Asn Phe Ser Ile Phe Lys Val Arg Met Phe 
625                 630                 635                 640 


Val Gly Gly His Glu His Arg Phe Ser Ala Ala Cys Asn Trp Thr Arg 
                645                 650                 655     


Gly Glu Arg Cys Asp Leu Glu Asp Arg Asp Arg Ser Glu Gln Gln Pro 
            660                 665                 670         


Leu Leu His Ser Thr Thr Asp Ser Leu Ile Leu Pro Cys Ser Phe Thr 
        675                 680                 685             


Pro Met Arg Arg Leu Ser Thr Gly Leu Ile His Leu His Gln Asn Ile 
    690                 695                 700                 


Val Asp Val Gln Tyr Leu Tyr Gly Val Gly Ser Ala Val Val Gly Trp 
705                 710                 715                 720 


Ala Leu Lys Trp Glu Phe Val Val Leu Val Phe Leu Leu Leu Ala Asp 
                725                 730                 735     


Ala Arg Val Cys Val Ala Leu Trp Met Met Leu Leu Ile Ser Gln Ala 
            740                 745                 750         


Glu Ala 
        


<210>  55
<211>  750
<212>  PRT
<213>  Hepatitis C virus

<400>  55

Met Ser Thr Asn Pro Lys Pro Gln Arg Leu Thr Lys Arg Asn Thr Val 
1               5                   10                  15      


Arg Arg Pro Gln Asn Val Lys Phe Pro Gly Gly Gly Gln Ile Val Gly 
            20                  25                  30          


Gly Val Tyr Leu Leu Pro Arg Arg Gly Pro Arg Leu Gly Val Arg Gly 
        35                  40                  45              


Thr Arg Lys Ser Ser Glu Arg Ser Gln Pro Arg Gly Arg Arg Gln Arg 
    50                  55                  60                  


Ile Pro Lys Ala Ala Ser Ser Gln Gly Lys Ala Trp Gly Lys Pro Gly 
65                  70                  75                  80  


Tyr Pro Trp Pro Leu Tyr Gly Asn Glu Gly Cys Gly Trp Ala Gly Trp 
                85                  90                  95      


Leu Leu Ser Pro Arg Gly Ser Arg Pro Thr Trp Gly Pro Thr Asp Pro 
            100                 105                 110         


Arg His Arg Ser Arg Asn Leu Gly Lys Val Ile Asp Thr Met Thr Cys 
        115                 120                 125             


Gly Phe Ala Asp Leu Met Gly Tyr Ile Pro Val Leu Gly Ala Pro Leu 
    130                 135                 140                 


Gly Gly Val Ala Arg Ala Leu Ala His Gly Val Arg Val Leu Glu Asp 
145                 150                 155                 160 


Gly Val Asn Tyr Ala Thr Gly Asn Leu Pro Gly Cys Ser Phe Ser Ile 
                165                 170                 175     


Phe Leu Leu Ala Leu Leu Ser Cys Leu Thr Val Pro Ala Ser Ala Tyr 
            180                 185                 190         


Glu Val Arg Asn Ser Ser Gly Val Tyr His Leu Thr Asn Asp Cys Pro 
        195                 200                 205             


Asn Ala Ser Ile Val Tyr Glu Thr Asp Asn Ala Ile Leu His Glu Pro 
    210                 215                 220                 


Gly Cys Val Pro Cys Val Arg Glu Gly Asn Thr Ser Arg Cys Trp Glu 
225                 230                 235                 240 


Pro Val Ala Pro Thr Leu Ala Val Arg Tyr Arg Gly Ala Leu Thr Asp 
                245                 250                 255     


Asp Leu Arg Thr His Ile Asp Leu Val Val Ala Ser Ala Thr Leu Cys 
            260                 265                 270         


Ser Ala Leu Tyr Val Gly Asp Ile Cys Gly Ala Ile Phe Ile Ala Ser 
        275                 280                 285             


Gln Ala Val Leu Trp Lys Pro Gly Gly Gly Arg Ile Val Gln Asp Cys 
    290                 295                 300                 


Asn Cys Ser Ile Tyr Pro Gly His Val Thr Gly His Arg Met Ala Trp 
305                 310                 315                 320 


Asp Met Met Gln Asn Trp Ala Pro Ala Leu Ser Met Val Ala Ala Tyr 
                325                 330                 335     


Ala Val Arg Val Pro Gly Val Ile Ile Thr Thr Val Ala Gly Gly His 
            340                 345                 350         


Trp Gly Val Leu Phe Gly Leu Ala Tyr Phe Gly Met Ala Gly Asn Trp 
        355                 360                 365             


Ala Lys Val Ile Leu Ile Met Leu Leu Met Ser Gly Val Asp Ala Glu 
    370                 375                 380                 


Thr Met Ala Val Gly Ala Arg Ala Ala His Thr Thr Gly Ala Leu Val 
385                 390                 395                 400 


Ser Leu Leu Asn Pro Gly Pro Ser Gln Arg Leu Gln Leu Ile Asn Thr 
                405                 410                 415     


Asn Gly Ser Trp His Ile Asn Arg Thr Ala Leu Asn Cys Asn Asp Ser 
            420                 425                 430         


Leu Gln Thr Gly Phe Ile Ala Ala Leu Phe Tyr Thr His Arg Phe Asn 
        435                 440                 445             


Ser Ser Gly Cys Pro Glu Arg Met Ala Ser Cys Lys Pro Leu Ser Asp 
    450                 455                 460                 


Phe Asp Gln Gly Trp Gly Pro Leu Trp Tyr Asn Ser Thr Glu Arg Pro 
465                 470                 475                 480 


Ser Asp Gln Arg Pro Tyr Cys Trp His Tyr Ala Pro Ser Pro Cys Gly 
                485                 490                 495     


Ile Val Pro Ala Lys Asp Val Cys Gly Pro Val Tyr Cys Phe Thr Pro 
            500                 505                 510         


Ser Pro Val Val Val Gly Thr Thr Asp Arg Arg Gly Val Pro Thr Tyr 
        515                 520                 525             


Thr Trp Gly Glu Asn Glu Ser Asp Val Phe Leu Leu Asn Ser Thr Arg 
    530                 535                 540                 


Pro Pro Gln Gly Ser Trp Phe Gly Cys Ser Trp Met Asn Thr Thr Gly 
545                 550                 555                 560 


Phe Thr Lys Thr Cys Gly Gly Pro Pro Cys Lys Ile Arg Pro Gln Gly 
                565                 570                 575     


Ala Gln Ser Asn Thr Ser Leu Thr Cys Pro Thr Asp Cys Phe Arg Lys 
            580                 585                 590         


His Pro Arg Ala Thr Tyr Ser Ala Cys Gly Ser Gly Pro Trp Leu Thr 
        595                 600                 605             


Pro Arg Cys Met Val His Tyr Pro Tyr Arg Leu Trp His Tyr Pro Cys 
    610                 615                 620                 


Thr Val Asn Phe Thr Ile His Lys Val Arg Leu Tyr Ile Gly Gly Val 
625                 630                 635                 640 


Glu His Arg Leu Asp Ala Ala Cys Asn Trp Thr Arg Gly Glu Arg Cys 
                645                 650                 655     


Asp Leu Glu Asp Arg Asp Arg Val Asp Met Ser Pro Leu Leu His Ser 
            660                 665                 670         


Thr Thr Glu Leu Ala Ile Leu Pro Cys Ser Phe Val Pro Leu Pro Ala 
        675                 680                 685             


Leu Ser Thr Gly Leu Ile His Leu His Gln Asn Ile Val Asp Ala Gln 
    690                 695                 700                 


Tyr Leu Tyr Gly Leu Ser Pro Ala Ile Ile Ser Trp Ala Ile Arg Trp 
705                 710                 715                 720 


Glu Trp Val Val Leu Val Phe Leu Leu Leu Ala Asp Ala Arg Ile Cys 
                725                 730                 735     


Ala Cys Leu Trp Met Met Met Leu Met Ala Gln Ala Glu Ala 
            740                 745                 750 


<210>  56
<211>  227
<212>  PRT
<213>  Homo sapiens

<400>  56

Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly 
1               5                   10                  15      


Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
            20                  25                  30          


Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
        35                  40                  45              


Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
    50                  55                  60                  


His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr 
65                  70                  75                  80  


Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
                85                  90                  95      


Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile 
            100                 105                 110         


Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
        115                 120                 125             


Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser 
    130                 135                 140                 


Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
145                 150                 155                 160 


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
                165                 170                 175     


Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val 
            180                 185                 190         


Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
        195                 200                 205             


His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
    210                 215                 220                 


Pro Gly Lys 
225         


<210>  57
<211>  325
<212>  PRT
<213>  Homo sapiens

<400>  57

Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Cys Ser Arg Ser 
1               5                   10                  15      


Thr Ser Glu Ser Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe 
            20                  25                  30          


Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly 
        35                  40                  45              


Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu 
    50                  55                  60                  


Ser Ser Val Val Thr Val Pro Ser Ser Asn Phe Gly Thr Gln Thr Tyr 
65                  70                  75                  80  


Thr Cys Asn Val Asp His Lys Pro Ser Asn Thr Lys Val Asp Lys Thr 
                85                  90                  95      


Val Glu Arg Lys Cys Cys Val Glu Cys Pro Pro Cys Pro Ala Pro Pro 
            100                 105                 110         


Val Ala Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr 
        115                 120                 125             


Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val 
    130                 135                 140                 


Ser His Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val 
145                 150                 155                 160 


Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser 
                165                 170                 175     


Thr Phe Arg Val Val Ser Val Leu Thr Val Val His Gln Asp Trp Leu 
            180                 185                 190         


Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ala 
        195                 200                 205             


Pro Ile Glu Lys Thr Ile Ser Lys Thr Lys Gly Gln Pro Arg Glu Pro 
    210                 215                 220                 


Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln 
225                 230                 235                 240 


Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala 
                245                 250                 255     


Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr 
            260                 265                 270         


Pro Pro Met Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu 
        275                 280                 285             


Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser 
    290                 295                 300                 


Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser 
305                 310                 315                 320 


Leu Ser Pro Gly Lys 
                325 


<210>  58
<211>  246
<212>  PRT
<213>  Homo sapiens

<400>  58

His Lys Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu Leu Lys Thr 
1               5                   10                  15      


Pro Leu Gly Asp Thr Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu 
            20                  25                  30          


Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp 
        35                  40                  45              


Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp 
    50                  55                  60                  


Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly 
65                  70                  75                  80  


Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn 
                85                  90                  95      


Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp 
            100                 105                 110         


Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro 
        115                 120                 125             


Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu 
    130                 135                 140                 


Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn 
145                 150                 155                 160 


Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile 
                165                 170                 175     


Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr 
            180                 185                 190         


Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys 
        195                 200                 205             


Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys 
    210                 215                 220                 


Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu 
225                 230                 235                 240 


Ser Leu Ser Pro Gly Lys 
                245     


<210>  59
<211>  383
<212>  PRT
<213>  Homo sapiens

<400>  59

Pro Thr Lys Ala Pro Asp Val Phe Pro Ile Ile Ser Gly Cys Arg His 
1               5                   10                  15      


Pro Lys Asp Asn Ser Pro Val Val Leu Ala Cys Leu Ile Thr Gly Tyr 
            20                  25                  30          


His Pro Thr Ser Val Thr Val Thr Trp Tyr Met Gly Thr Gln Ser Gln 
        35                  40                  45              


Pro Gln Arg Thr Phe Pro Glu Ile Gln Arg Arg Asp Ser Tyr Tyr Met 
    50                  55                  60                  


Thr Ser Ser Gln Leu Ser Thr Pro Leu Gln Gln Trp Arg Gln Gly Glu 
65                  70                  75                  80  


Tyr Lys Cys Val Val Gln His Thr Ala Ser Lys Ser Lys Lys Glu Ile 
                85                  90                  95      


Phe Arg Trp Pro Glu Ser Pro Lys Ala Gln Ala Ser Ser Val Pro Thr 
            100                 105                 110         


Ala Gln Pro Gln Ala Glu Gly Ser Leu Ala Lys Ala Thr Thr Ala Pro 
        115                 120                 125             


Ala Thr Thr Arg Asn Thr Gly Arg Gly Gly Glu Glu Lys Lys Lys Glu 
    130                 135                 140                 


Lys Glu Lys Glu Glu Gln Glu Glu Arg Glu Thr Lys Thr Pro Glu Cys 
145                 150                 155                 160 


Pro Ser His Thr Gln Pro Leu Gly Val Tyr Leu Leu Thr Pro Ala Val 
                165                 170                 175     


Gln Asp Leu Trp Leu Arg Asp Lys Ala Thr Phe Thr Cys Phe Val Val 
            180                 185                 190         


Gly Ser Asp Leu Lys Asp Ala His Leu Thr Trp Glu Val Ala Gly Lys 
        195                 200                 205             


Val Pro Thr Gly Gly Val Glu Glu Gly Leu Leu Glu Arg His Ser Asn 
    210                 215                 220                 


Gly Ser Gln Ser Gln His Ser Arg Leu Thr Leu Pro Arg Ser Leu Trp 
225                 230                 235                 240 


Asn Ala Gly Thr Ser Val Thr Cys Thr Leu Asn His Pro Ser Leu Pro 
                245                 250                 255     


Pro Gln Arg Leu Met Ala Leu Arg Glu Pro Ala Ala Gln Ala Pro Val 
            260                 265                 270         


Lys Leu Ser Leu Asn Leu Leu Ala Ser Ser Asp Pro Pro Glu Ala Ala 
        275                 280                 285             


Ser Trp Leu Leu Cys Glu Val Ser Gly Phe Ser Pro Pro Asn Ile Leu 
    290                 295                 300                 


Leu Met Trp Leu Glu Asp Gln Arg Glu Val Asn Thr Ser Gly Phe Ala 
305                 310                 315                 320 


Pro Ala Arg Pro Pro Pro Gln Pro Arg Ser Thr Thr Phe Trp Ala Trp 
                325                 330                 335     


Ser Val Leu Arg Val Pro Ala Pro Pro Ser Pro Gln Pro Ala Thr Tyr 
            340                 345                 350         


Thr Cys Val Val Ser His Glu Asp Ser Arg Thr Leu Leu Asn Ala Ser 
        355                 360                 365             


Arg Ser Leu Glu Val Ser Tyr Val Thr Asp His Gly Pro Met Lys 
    370                 375                 380             


<210>  60
<211>  276
<212>  PRT
<213>  Homo sapiens

<400>  60

Val Thr Ser Thr Leu Thr Ile Lys Glx Ser Asp Trp Leu Gly Glu Ser 
1               5                   10                  15      


Met Phe Thr Cys Arg Val Asp His Arg Gly Leu Thr Phe Gln Gln Asn 
            20                  25                  30          


Ala Ser Ser Met Cys Val Pro Asp Gln Asp Thr Ala Ile Arg Val Phe 
        35                  40                  45              


Ala Ile Pro Pro Ser Phe Ala Ser Ile Phe Leu Thr Lys Ser Thr Lys 
    50                  55                  60                  


Leu Thr Cys Leu Val Thr Asp Leu Thr Thr Tyr Asx Ser Val Thr Ile 
65                  70                  75                  80  


Ser Trp Thr Arg Glu Glu Asn Gly Ala Val Lys Thr His Thr Asn Ile 
                85                  90                  95      


Ser Glu Ser His Pro Asn Ala Thr Phe Ser Ala Val Gly Glu Ala Ser 
            100                 105                 110         


Ile Cys Glu Asp Asx Asp Trp Ser Gly Glu Arg Phe Thr Cys Thr Val 
        115                 120                 125             


Thr His Thr Asp Leu Pro Ser Pro Leu Lys Gln Thr Ile Ser Arg Pro 
    130                 135                 140                 


Lys Gly Val Ala Leu His Arg Pro Asx Val Tyr Leu Leu Pro Pro Ala 
145                 150                 155                 160 


Arg Glx Glx Leu Asn Leu Arg Glu Ser Ala Thr Ile Thr Cys Leu Val 
                165                 170                 175     


Thr Gly Phe Ser Pro Ala Asp Val Phe Val Glu Trp Met Gln Arg Gly 
            180                 185                 190         


Glu Pro Leu Ser Pro Gln Lys Tyr Val Thr Ser Ala Pro Met Pro Glu 
        195                 200                 205             


Pro Gln Ala Pro Gly Arg Tyr Phe Ala His Ser Ile Leu Thr Val Ser 
    210                 215                 220                 


Glu Glu Glu Trp Asn Thr Gly Gly Thr Tyr Thr Cys Val Val Ala His 
225                 230                 235                 240 


Glu Ala Leu Pro Asn Arg Val Thr Glu Arg Thr Val Asp Lys Ser Thr 
                245                 250                 255     


Gly Lys Pro Thr Leu Tyr Asn Val Ser Leu Val Met Ser Asp Thr Ala 
            260                 265                 270         


Gly Thr Cys Tyr 
        275     


<210>  61
<211>  353
<212>  PRT
<213>  Homo sapiens

<400>  61

Ala Ser Pro Thr Ser Pro Lys Val Phe Pro Leu Ser Leu Cys Ser Thr 
1               5                   10                  15      


Gln Pro Asp Gly Asn Val Val Ile Ala Cys Leu Val Gln Gly Phe Phe 
            20                  25                  30          


Pro Gln Glu Pro Leu Ser Val Thr Trp Ser Glu Ser Gly Gln Gly Val 
        35                  40                  45              


Thr Ala Arg Asn Phe Pro Pro Ser Gln Asp Ala Ser Gly Asp Leu Tyr 
    50                  55                  60                  


Thr Thr Ser Ser Gln Leu Thr Leu Pro Ala Thr Gln Cys Leu Ala Gly 
65                  70                  75                  80  


Lys Ser Val Thr Cys His Val Lys His Tyr Thr Asn Pro Ser Gln Asp 
                85                  90                  95      


Val Thr Val Pro Cys Pro Val Pro Ser Thr Pro Pro Thr Pro Ser Pro 
            100                 105                 110         


Ser Thr Pro Pro Thr Pro Ser Pro Ser Cys Cys His Pro Arg Leu Ser 
        115                 120                 125             


Leu His Arg Pro Ala Leu Glu Asp Leu Leu Leu Gly Ser Glu Ala Asn 
    130                 135                 140                 


Leu Thr Cys Thr Leu Thr Gly Leu Arg Asp Ala Ser Gly Val Thr Phe 
145                 150                 155                 160 


Thr Trp Thr Pro Ser Ser Gly Lys Ser Ala Val Gln Gly Pro Pro Glu 
                165                 170                 175     


Arg Asp Leu Cys Gly Cys Tyr Ser Val Ser Ser Val Leu Pro Gly Cys 
            180                 185                 190         


Ala Glu Pro Trp Asn His Gly Lys Thr Phe Thr Cys Thr Ala Ala Tyr 
        195                 200                 205             


Pro Glu Ser Lys Thr Pro Leu Thr Ala Thr Leu Ser Lys Ser Gly Asn 
    210                 215                 220                 


Thr Phe Arg Pro Glu Val His Leu Leu Pro Pro Pro Ser Glu Glu Leu 
225                 230                 235                 240 


Ala Leu Asn Glu Leu Val Thr Leu Thr Cys Leu Ala Arg Gly Phe Ser 
                245                 250                 255     


Pro Lys Asp Val Leu Val Arg Trp Leu Gln Gly Ser Gln Glu Leu Pro 
            260                 265                 270         


Arg Glu Lys Tyr Leu Thr Trp Ala Ser Arg Gln Glu Pro Ser Gln Gly 
        275                 280                 285             


Thr Thr Thr Phe Ala Val Thr Ser Ile Leu Arg Val Ala Ala Glu Asp 
    290                 295                 300                 


Trp Lys Lys Gly Asp Thr Phe Ser Cys Met Val Gly His Glu Ala Leu 
305                 310                 315                 320 


Pro Leu Ala Phe Thr Gln Lys Thr Ile Asp Arg Leu Ala Gly Lys Pro 
                325                 330                 335     


Thr His Val Asn Val Ser Val Val Met Ala Glu Val Asp Gly Thr Cys 
            340                 345                 350         


Tyr 
    


<210>  62
<211>  222
<212>  PRT
<213>  Homo sapiens

<400>  62

Ala Asp Pro Cys Asp Ser Asn Pro Arg Gly Val Ser Ala Tyr Leu Ser 
1               5                   10                  15      


Arg Pro Ser Pro Phe Asp Leu Phe Ile Arg Lys Ser Pro Thr Ile Thr 
            20                  25                  30          


Cys Leu Val Val Asp Leu Ala Pro Ser Lys Gly Thr Val Asn Leu Thr 
        35                  40                  45              


Trp Ser Arg Ala Ser Gly Lys Pro Val Asn His Ser Thr Arg Lys Glu 
    50                  55                  60                  


Glu Lys Gln Arg Asn Gly Thr Leu Thr Val Thr Ser Thr Leu Pro Val 
65                  70                  75                  80  


Gly Thr Arg Asp Trp Ile Glu Gly Glu Thr Tyr Gln Cys Arg Val Thr 
                85                  90                  95      


His Pro His Leu Pro Arg Ala Leu Met Arg Ser Thr Thr Lys Thr Ser 
            100                 105                 110         


Gly Pro Arg Ala Ala Pro Glu Val Tyr Ala Phe Ala Thr Pro Glu Trp 
        115                 120                 125             


Pro Gly Ser Arg Asp Lys Arg Thr Leu Ala Cys Leu Ile Gln Asn Phe 
    130                 135                 140                 


Met Pro Glu Asp Ile Ser Val Gln Trp Leu His Asn Glu Val Gln Leu 
145                 150                 155                 160 


Pro Asp Ala Arg His Ser Thr Thr Gln Pro Arg Lys Thr Lys Gly Ser 
                165                 170                 175     


Gly Phe Phe Val Phe Ser Arg Leu Glu Val Thr Arg Ala Glu Trp Glu 
            180                 185                 190         


Gln Lys Asp Glu Phe Ile Cys Arg Ala Val His Glu Ala Ala Ser Pro 
        195                 200                 205             


Ser Gln Thr Val Gln Arg Ala Val Ser Val Asn Pro Gly Lys 
    210                 215                 220         


<210>  63
<211>  327
<212>  PRT
<213>  Homo sapiens

<400>  63

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Cys Ser Arg 
1               5                   10                  15      


Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Lys Thr 
65                  70                  75                  80  


Tyr Thr Cys Asn Val Asp His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Arg Val Glu Ser Lys Tyr Gly Pro Pro Cys Pro Ser Cys Pro Ala Pro 
            100                 105                 110         


Glu Phe Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys 
        115                 120                 125             


Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val 
    130                 135                 140                 


Asp Val Ser Gln Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp 
145                 150                 155                 160 


Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe 
                165                 170                 175     


Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp 
            180                 185                 190         


Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu 
        195                 200                 205             


Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg 
    210                 215                 220                 


Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met Thr Lys 
225                 230                 235                 240 


Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp 
                245                 250                 255     


Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys 
            260                 265                 270         


Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser 
        275                 280                 285             


Arg Leu Thr Val Asp Lys Ser Arg Trp Gln Glu Gly Asn Val Phe Ser 
    290                 295                 300                 


Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser 
305                 310                 315                 320 


Leu Ser Leu Ser Leu Gly Lys 
                325         


<210>  64
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Sequence

<400>  64

Val Leu Val Leu Asn Pro Ser Val Ala Ala Thr Leu Gly Phe Gly 
1               5                   10                  15  


<210>  65
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Sequence

<400>  65

Thr Tyr Gly Lys Phe Leu Ala Asp Gly Gly Cys Ser Gly Gly Ala 
1               5                   10                  15  


<210>  66
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Sequence

<400>  66

Gly Gly Arg His Leu Ile Phe Cys His Ser Lys Lys Lys Cys Asp 
1               5                   10                  15  


<210>  67
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Sequence

<400>  67

Val Ala Tyr Tyr Arg Gly Leu Asp Val Ser Val 
1               5                   10      


<210>  68
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Sequence

<400>  68

Ala Thr Asp Ala Leu Met Thr Gly Phe Thr Gly Asp Phe Asp Ser Val 
1               5                   10                  15      


Ile Asp 
        


<210>  69
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Sequence

<400>  69

Thr Gly Leu Thr His Ile Asp Ala His Phe Leu Ser Gln Thr Lys 
1               5                   10                  15  


<210>  70
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Sequence

<400>  70

Gln Tyr Leu Ala Gly Leu Ser Thr Leu Pro Gly Asn Pro 
1               5                   10              


<210>  71
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Sequence

<400>  71

Asn Leu Leu Pro Ala Ile Leu Ser 
1               5               


<210>  72
<211>  27
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Sequence

<400>  72

Arg His Val Gly Pro Gly Glu Gly Ala Val Gln Trp Met Asn Arg Leu 
1               5                   10                  15      


Ile Ala Phe Ala Ser Arg Gly Asn His Val Ser 
            20                  25          


<210>  73
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Sequence

<400>  73

Ser Ser Ala Ser Gln Leu Ser Ala Pro Ser Leu Lys Ala Thr Cys 
1               5                   10                  15  


<210>  74
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Sequence

<400>  74

Ser Asn Val Ser Val 
1               5   


<210>  75
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Sequence

<400>  75

Thr Tyr Ser Thr Tyr Gly Lys Phe Leu 
1               5                   


<210>  76
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Sequence

<400>  76

Leu Ile Phe Cys His Ser Lys Lys Lys 
1               5                   


<210>  77
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Sequence

<400>  77

Ala Thr Asp Ala Leu Met Thr Gly Phe Thr Gly Asp Phe Asp Ser Val 
1               5                   10                  15      


<210>  78
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Sequence

<400>  78

Val Leu Ala Ala Leu Ala Ala Tyr Cys Leu 
1               5                   10  


<210>  79
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Sequence

<400>  79

Ile Leu Ala Gly Tyr Gly Ala Gly Val 
1               5                   


<210>  80
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Sequence

<400>  80

Ile Pro Phe Tyr Gly Lys Ala Ile 
1               5               


<210>  81
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Sequence

<400>  81

Arg Ala Gln Ala Pro Pro Pro Ser Trp 
1               5                   


<210>  82
<211>  36
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Sequence

<400>  82

Glu Gly Ala Val Gln Trp Met Asn Arg Leu Ile Ala Phe Ala Ser Arg 
1               5                   10                  15      


Gly Asn His Val Ser Pro Thr His Tyr Val Pro Glu Ser Asp Ala Ala 
            20                  25                  30          


Ala Arg Val Thr 
        35      


<210>  83
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Sequence

<400>  83

Arg Pro Asp Tyr Asn Pro Pro Leu Leu 
1               5                   


<210>  84
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Sequence

<400>  84

Thr Ile Met Ala Lys Asn Glu Val Phe 
1               5                   


<210>  85
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Sequence

<400>  85

Ala Ile Pro Leu Glu Val Ile Lys Gly Gly Arg His Leu Ile Phe Cys 
1               5                   10                  15      


His Ser Lys Lys Lys Cys Asp Glu Leu Ala Ala Lys Leu 
            20                  25                  


<210>  86
<211>  50
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Sequence

<400>  86

Leu Gly Ala Leu Thr Gly Thr Tyr Val Tyr Asn His Leu Thr Pro Leu 
1               5                   10                  15      


Arg Asp Trp Ala His Asn Gly Leu Arg Asp Leu Ala Val Ala Val Glu 
            20                  25                  30          


Pro Val Val Phe Ser Gln Met Glu Thr Lys Leu Ile Thr Trp Gly Ala 
        35                  40                  45              


Asp Thr 
    50  


<210>  87
<211>  52
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Sequence

<400>  87

Ala Ile Pro Leu Glu Val Ile Lys Gly Gly Arg His Leu Ile Phe Cys 
1               5                   10                  15      


His Ser Lys Lys Lys Cys Asp Glu Leu Ala Ala Lys Leu Val Ala Leu 
            20                  25                  30          


Gly Ile Asn Ala Val Ala Tyr Tyr Arg Gly Leu Asp Val Ser Val Ile 
        35                  40                  45              


Pro Thr Ser Gly 
    50          


<210>  88
<211>  70
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Sequence

<400>  88

Lys Gly Gly Arg His Leu Ile Phe Cys His Ser Lys Lys Lys Cys Asp 
1               5                   10                  15      


Glu Leu Ala Ala Lys Leu Val Ala Leu Gly Ile Asn Ala Val Ala Tyr 
            20                  25                  30          


Tyr Arg Gly Leu Asp Val Ser Val Ile Pro Thr Ser Gly Asp Val Val 
        35                  40                  45              


Val Val Ala Thr Asp Ala Leu Met Thr Gly Phe Thr Gly Asp Phe Asp 
    50                  55                  60                  


Ser Val Ile Asp Cys Asn 
65                  70  


<210>  89
<211>  100
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Sequence

<400>  89

Val Ala Leu Ser Thr Thr Gly Glu Ile Pro Phe Tyr Gly Lys Ala Ile 
1               5                   10                  15      


Pro Leu Glu Val Ile Lys Gly Gly Arg His Leu Ile Phe Cys His Ser 
            20                  25                  30          


Lys Lys Lys Cys Asp Glu Leu Ala Ala Lys Leu Val Ala Leu Gly Ile 
        35                  40                  45              


Asn Ala Val Ala Tyr Tyr Arg Gly Leu Asp Val Ser Val Ile Pro Thr 
    50                  55                  60                  


Ser Gly Asp Val Val Val Val Ala Thr Asp Ala Leu Met Thr Gly Phe 
65                  70                  75                  80  


Thr Gly Asp Phe Asp Ser Val Ile Asp Cys Asn Thr Cys Val Thr Gln 
                85                  90                  95      


Thr Val Asp Phe 
            100 


<210>  90
<211>  171
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Sequence

<400>  90

Met Ser Thr Asn Pro Lys Pro Gln Arg Lys Thr Lys Arg Asn Thr Asn 
1               5                   10                  15      


Arg Arg Pro Gln Asp Val Lys Phe Pro Gly Gly Gly Gln Ile Val Gly 
            20                  25                  30          


Gly Val Tyr Leu Leu Pro Arg Arg Gly Pro Arg Leu Gly Val Arg Ala 
        35                  40                  45              


Thr Arg Lys Thr Ser Glu Arg Ser Gln Pro Arg Gly Arg Arg Gln Pro 
    50                  55                  60                  


Ile Pro Lys Ala Arg Arg Pro Glu Gly Arg Thr Trp Ala Gln Pro Gly 
65                  70                  75                  80  


Tyr Pro Trp Pro Leu Tyr Gly Asn Glu Gly Cys Gly Trp Ala Gly Trp 
                85                  90                  95      


Leu Leu Ser Pro Arg Gly Ser Arg Pro Ser Trp Gly Pro Thr Asp Pro 
            100                 105                 110         


Arg Arg Arg Ser Arg Asn Leu Gly Lys Val Ile Asp Thr Leu Thr Cys 
        115                 120                 125             


Gly Phe Ala Asp Leu Met Gly Tyr Ile Pro Leu Val Gly Ala Pro Leu 
    130                 135                 140                 


Gly Gly Ala Ala Arg Ala Leu Ala His Gly Val Arg Val Leu Glu Asp 
145                 150                 155                 160 


Gly Val Asn Tyr Ala Thr Gly Asn Leu Pro Gly 
                165                 170     


<210>  91
<211>  228
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Sequence

<400>  91

Leu His Ala Pro Thr Gly Ser Gly Lys Ser Thr Lys Val Pro Ala Ala 
1               5                   10                  15      


Tyr Ala Ala Gln Gly Tyr Lys Val Leu Val Leu Asn Pro Ser Val Ala 
            20                  25                  30          


Ala Thr Leu Gly Phe Gly Ala Tyr Met Ser Lys Ala His Gly Ile Asp 
        35                  40                  45              


Pro Asn Ile Arg Thr Gly Val Arg Thr Ile Thr Thr Gly Ser Pro Ile 
    50                  55                  60                  


Thr Tyr Ser Thr Tyr Gly Lys Phe Leu Ala Asp Gly Gly Cys Ser Gly 
65                  70                  75                  80  


Gly Ala Tyr Asp Ile Ile Ile Cys Asp Glu Cys His Ser Thr Asp Ala 
                85                  90                  95      


Thr Ser Ile Leu Gly Ile Gly Thr Val Leu Asp Gln Ala Glu Thr Ala 
            100                 105                 110         


Gly Ala Arg Leu Val Val Leu Ala Thr Ala Thr Pro Pro Gly Ser Val 
        115                 120                 125             


Thr Val Pro His Pro Asn Ile Glu Glu Val Ala Leu Ser Thr Thr Gly 
    130                 135                 140                 


Glu Ile Pro Phe Tyr Gly Lys Ala Ile Pro Leu Glu Val Ile Lys Gly 
145                 150                 155                 160 


Gly Arg His Leu Ile Phe Cys His Ser Lys Lys Lys Cys Asp Glu Leu 
                165                 170                 175     


Ala Ala Lys Leu Val Ala Leu Gly Ile Asn Ala Val Ala Tyr Tyr Arg 
            180                 185                 190         


Gly Leu Asp Val Ser Val Ile Pro Thr Ser Gly Asp Val Val Val Val 
        195                 200                 205             


Ala Thr Asp Ala Leu Met Thr Gly Phe Thr Gly Asp Phe Asp Ser Val 
    210                 215                 220                 


Ile Asp Cys Asn 
225             


<210>  92
<211>  553
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Sequence

<400>  92

Gln Ala Ser Leu Leu Lys Val Pro Tyr Phe Val Arg Val Gln Gly Leu 
1               5                   10                  15      


Leu Arg Ile Cys Ala Leu Ala Arg Lys Met Ala Gly Gly His Tyr Val 
            20                  25                  30          


Gln Met Ala Ile Ile Lys Leu Gly Ala Leu Thr Gly Thr Tyr Val Tyr 
        35                  40                  45              


Asn Ala Leu Thr Pro Leu Arg Asp Trp Ala His Asn Gly Leu Arg Asp 
    50                  55                  60                  


Leu Ala Val Ala Val Glu Pro Val Val Phe Ser Gln Met Glu Thr Lys 
65                  70                  75                  80  


Leu Ile Thr Trp Gly Ala Asp Thr Ala Ala Cys Gly Asp Ile Ile Asn 
                85                  90                  95      


Gly Leu Pro Val Ser Ala Arg Arg Gly Arg Glu Ile Leu Leu Gly Pro 
            100                 105                 110         


Ala Asp Gly Met Val Ser Lys Gly Trp Arg Leu Leu Ala Pro Ile Thr 
        115                 120                 125             


Ala Tyr Ala Gln Gln Thr Arg Gly Leu Leu Gly Cys Ile Ile Thr Ser 
    130                 135                 140                 


Leu Thr Gly Arg Asp Lys Asn Gln Val Glu Gly Glu Val Gln Ile Val 
145                 150                 155                 160 


Ser Thr Ala Ala Gln Thr Phe Leu Ala Thr Cys Ile Asn Gly Val Cys 
                165                 170                 175     


Trp Thr Val Tyr His Gly Ala Gly Thr Arg Thr Ile Ala Ser Pro Lys 
            180                 185                 190         


Gly Pro Val Ile Gln Met Tyr Thr Asn Val Asp Gln Asp Leu Val Gly 
        195                 200                 205             


Trp Pro Ala Pro Gln Gly Ala Arg Ser Leu Thr Pro Cys Thr Cys Gly 
    210                 215                 220                 


Ser Ser Asp Leu Tyr Leu Val Thr Arg His Ala Asp Val Ile Pro Val 
225                 230                 235                 240 


Arg Arg Arg Gly Asp Ser Arg Gly Ser Leu Leu Ser Pro Arg Pro Ile 
                245                 250                 255     


Ser Tyr Leu Lys Gly Ser Ala Gly Gly Pro Leu Leu Cys Pro Ala Gly 
            260                 265                 270         


His Ala Val Gly Ile Phe Arg Ala Ala Val Cys Thr Arg Gly Val Ala 
        275                 280                 285             


Lys Ala Val Asp Phe Ile Pro Val Glu Asn Leu Glu Thr Thr Met Arg 
    290                 295                 300                 


Ser Pro Val Phe Thr Asp Asn Ser Ser Pro Pro Ala Val Pro Gln Ser 
305                 310                 315                 320 


Phe Gln Val Ala His Leu His Ala Pro Thr Gly Ser Gly Lys Ser Thr 
                325                 330                 335     


Lys Val Pro Ala Ala Tyr Ala Ala Gln Gly Tyr Lys Val Leu Val Leu 
            340                 345                 350         


Asn Pro Ser Val Ala Ala Thr Leu Gly Phe Gly Ala Tyr Met Ser Lys 
        355                 360                 365             


Ala His Gly Ile Asp Pro Asn Ile Arg Thr Gly Val Arg Thr Ile Thr 
    370                 375                 380                 


Thr Gly Ser Pro Ile Thr Tyr Ser Thr Tyr Gly Lys Phe Leu Ala Asp 
385                 390                 395                 400 


Gly Gly Cys Ser Gly Gly Ala Tyr Asp Ile Ile Ile Cys Asp Glu Cys 
                405                 410                 415     


His Ser Thr Asp Ala Thr Ser Ile Leu Gly Ile Gly Thr Val Leu Asp 
            420                 425                 430         


Gln Ala Glu Thr Ala Gly Ala Arg Leu Val Val Leu Ala Thr Ala Thr 
        435                 440                 445             


Pro Pro Gly Ser Val Thr Val Pro His Pro Asn Ile Glu Glu Val Ala 
    450                 455                 460                 


Leu Ser Thr Thr Gly Glu Ile Pro Phe Tyr Gly Lys Ala Ile Pro Leu 
465                 470                 475                 480 


Glu Val Ile Lys Gly Gly Arg His Leu Ile Phe Cys His Ser Lys Lys 
                485                 490                 495     


Lys Cys Asp Glu Leu Ala Ala Lys Leu Val Ala Leu Gly Ile Asn Ala 
            500                 505                 510         


Val Ala Tyr Tyr Arg Gly Leu Asp Val Ser Val Ile Pro Thr Ser Gly 
        515                 520                 525             


Asp Val Val Val Val Ala Thr Asp Ala Leu Met Thr Gly Phe Thr Gly 
    530                 535                 540                 


Asp Phe Asp Ser Val Ile Asp Cys Asn 
545                 550             


<210>  93
<211>  778
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Sequence

<400>  93

Leu His Ala Pro Thr Gly Ser Gly Lys Ser Thr Lys Val Pro Ala Ala 
1               5                   10                  15      


Tyr Ala Ala Gln Gly Tyr Lys Val Leu Val Leu Asn Pro Ser Val Ala 
            20                  25                  30          


Ala Thr Leu Gly Phe Gly Ala Tyr Met Ser Lys Ala His Gly Ile Asp 
        35                  40                  45              


Pro Asn Ile Arg Thr Gly Val Arg Thr Ile Thr Thr Gly Ser Pro Ile 
    50                  55                  60                  


Thr Tyr Ser Thr Tyr Gly Lys Phe Leu Ala Asp Gly Gly Cys Ser Gly 
65                  70                  75                  80  


Gly Ala Tyr Asp Ile Ile Ile Cys Asp Glu Cys His Ser Thr Asp Ala 
                85                  90                  95      


Thr Ser Ile Leu Gly Ile Gly Thr Val Leu Asp Gln Ala Glu Thr Ala 
            100                 105                 110         


Gly Ala Arg Leu Val Val Leu Ala Thr Ala Thr Pro Pro Gly Ser Val 
        115                 120                 125             


Thr Val Pro His Pro Asn Ile Glu Glu Val Ala Leu Ser Thr Thr Gly 
    130                 135                 140                 


Glu Ile Pro Phe Tyr Gly Lys Ala Ile Pro Leu Glu Val Ile Lys Gly 
145                 150                 155                 160 


Gly Arg His Leu Ile Phe Cys His Ser Lys Lys Lys Cys Asp Glu Leu 
                165                 170                 175     


Ala Ala Lys Leu Val Ala Leu Gly Ile Asn Ala Val Ala Tyr Tyr Arg 
            180                 185                 190         


Gly Leu Asp Val Ser Val Ile Pro Thr Ser Gly Asp Val Val Val Val 
        195                 200                 205             


Ala Thr Asp Ala Leu Met Thr Gly Phe Thr Gly Asp Phe Asp Ser Val 
    210                 215                 220                 


Ile Asp Cys Asn Thr Cys Val Thr Gln Thr Val Asp Phe Ser Leu Asp 
225                 230                 235                 240 


Pro Thr Phe Thr Ile Glu Thr Thr Thr Leu Pro Gln Asp Ala Val Ser 
                245                 250                 255     


Arg Thr Gln Arg Arg Gly Arg Thr Gly Arg Gly Lys Pro Gly Ile Tyr 
            260                 265                 270         


Arg Phe Val Ala Pro Gly Glu Arg Pro Ser Gly Met Phe Asp Ser Ser 
        275                 280                 285             


Val Leu Cys Glu Cys Tyr Asp Ala Gly Cys Ala Trp Tyr Glu Leu Thr 
    290                 295                 300                 


Pro Ala Glu Thr Thr Val Arg Leu Arg Ala Tyr Met Asn Thr Pro Gly 
305                 310                 315                 320 


Leu Pro Val Cys Gln Asp His Leu Glu Phe Trp Glu Gly Val Phe Thr 
                325                 330                 335     


Gly Leu Thr His Ile Asp Ala His Phe Leu Ser Gln Thr Lys Gln Ser 
            340                 345                 350         


Gly Glu Asn Leu Pro Tyr Leu Val Ala Tyr Gln Ala Thr Val Cys Ala 
        355                 360                 365             


Arg Ala Gln Ala Pro Pro Pro Ser Trp Asp Gln Met Trp Lys Cys Leu 
    370                 375                 380                 


Ile Arg Leu Lys Pro Thr Leu His Gly Pro Thr Pro Leu Leu Tyr Arg 
385                 390                 395                 400 


Leu Gly Ala Val Gln Asn Glu Val Thr Leu Thr His Pro Ile Thr Lys 
                405                 410                 415     


Tyr Ile Met Thr Cys Met Ser Ala Asp Leu Glu Val Val Thr Ser Thr 
            420                 425                 430         


Trp Val Leu Val Gly Gly Val Leu Ala Ala Leu Ala Ala Tyr Cys Leu 
        435                 440                 445             


Ser Thr Gly Cys Val Val Ile Val Gly Arg Ile Val Leu Ser Gly Lys 
    450                 455                 460                 


Pro Ala Ile Ile Pro Asp Arg Glu Val Leu Tyr Arg Glu Phe Asp Glu 
465                 470                 475                 480 


Met Glu Glu Cys Ser Gln His Leu Pro Tyr Ile Glu Gln Gly Met Met 
                485                 490                 495     


Leu Ala Glu Gln Phe Lys Gln Lys Ala Leu Gly Leu Leu Gln Thr Ala 
            500                 505                 510         


Ser Arg Gln Ala Glu Val Ile Ala Pro Ala Val Gln Thr Asn Trp Gln 
        515                 520                 525             


Lys Leu Glu Ala Phe Trp Ala Lys His Met Trp Asn Phe Ile Ser Gly 
    530                 535                 540                 


Ile Gln Tyr Leu Ala Gly Leu Ser Thr Leu Pro Gly Asn Pro Ala Ile 
545                 550                 555                 560 


Ala Ser Leu Met Ala Phe Thr Ala Ala Val Thr Ser Pro Leu Thr Thr 
                565                 570                 575     


Ser Gln Thr Leu Leu Phe Asn Ile Leu Gly Gly Trp Val Ala Ala Gln 
            580                 585                 590         


Leu Ala Ala Pro Gly Ala Ala Thr Ala Phe Val Gly Ala Gly Leu Ala 
        595                 600                 605             


Gly Ala Ala Ile Gly Ser Val Gly Leu Gly Lys Val Leu Val Asp Ile 
    610                 615                 620                 


Leu Ala Gly Tyr Gly Ala Gly Val Ala Gly Ala Leu Val Ala Phe Lys 
625                 630                 635                 640 


Ile Met Ser Gly Glu Val Pro Ser Thr Glu Asp Leu Val Asn Leu Leu 
                645                 650                 655     


Pro Ala Ile Leu Ser Pro Gly Ala Leu Val Val Gly Val Val Cys Ala 
            660                 665                 670         


Ala Ile Leu Arg Arg His Val Gly Pro Gly Glu Gly Ala Val Gln Trp 
        675                 680                 685             


Met Asn Arg Leu Ile Ala Phe Ala Ser Arg Gly Asn His Val Ser Pro 
    690                 695                 700                 


Thr His Tyr Val Pro Glu Ser Asp Ala Ala Ala Arg Val Thr Ala Ile 
705                 710                 715                 720 


Leu Ser Ser Leu Thr Val Thr Gln Leu Leu Arg Arg Leu His Gln Trp 
                725                 730                 735     


Ile Ser Ser Glu Cys Thr Thr Pro Cys Ser Gly Ser Trp Leu Arg Asp 
            740                 745                 750         


Ile Trp Asp Trp Ile Cys Glu Val Leu Ser Asp Phe Lys Thr Trp Leu 
        755                 760                 765             


Lys Ala Lys Leu Met Pro Gln Leu Pro Gly 
    770                 775             


<210>  94
<211>  1985
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Sequence

<400>  94

Ala Pro Ile Thr Ala Tyr Ala Gln Gln Thr Arg Gly Leu Leu Gly Cys 
1               5                   10                  15      


Ile Ile Thr Ser Leu Thr Gly Arg Asp Lys Asn Gln Val Glu Gly Glu 
            20                  25                  30          


Val Gln Ile Val Ser Thr Ala Ala Gln Thr Phe Leu Ala Thr Cys Ile 
        35                  40                  45              


Asn Gly Val Cys Trp Thr Val Tyr His Gly Ala Gly Thr Arg Thr Ile 
    50                  55                  60                  


Ala Ser Pro Lys Gly Pro Val Ile Gln Met Tyr Thr Asn Val Asp Gln 
65                  70                  75                  80  


Asp Leu Val Gly Trp Pro Ala Pro Gln Gly Ala Arg Ser Leu Thr Pro 
                85                  90                  95      


Cys Thr Cys Gly Ser Ser Asp Leu Tyr Leu Val Thr Arg His Ala Asp 
            100                 105                 110         


Val Ile Pro Val Arg Arg Arg Gly Asp Ser Arg Gly Ser Leu Leu Ser 
        115                 120                 125             


Pro Arg Pro Ile Ser Tyr Leu Lys Gly Ser Ala Gly Gly Pro Leu Leu 
    130                 135                 140                 


Cys Pro Ala Gly His Ala Val Gly Ile Phe Arg Ala Ala Val Cys Thr 
145                 150                 155                 160 


Arg Gly Val Ala Lys Ala Val Asp Phe Ile Pro Val Glu Asn Leu Glu 
                165                 170                 175     


Thr Thr Met Arg Ser Pro Val Phe Thr Asp Asn Ser Ser Pro Pro Ala 
            180                 185                 190         


Val Pro Gln Ser Phe Gln Val Ala His Leu His Ala Pro Thr Gly Ser 
        195                 200                 205             


Gly Lys Ser Thr Lys Val Pro Ala Ala Tyr Ala Ala Gln Gly Tyr Lys 
    210                 215                 220                 


Val Leu Val Leu Asn Pro Ser Val Ala Ala Thr Leu Gly Phe Gly Ala 
225                 230                 235                 240 


Tyr Met Ser Lys Ala His Gly Ile Asp Pro Asn Ile Arg Thr Gly Val 
                245                 250                 255     


Arg Thr Ile Thr Thr Gly Ser Pro Ile Thr Tyr Ser Thr Tyr Gly Lys 
            260                 265                 270         


Phe Leu Ala Asp Gly Gly Cys Ser Gly Gly Ala Tyr Asp Ile Ile Ile 
        275                 280                 285             


Cys Asp Glu Cys His Ser Thr Asp Ala Thr Ser Ile Leu Gly Ile Gly 
    290                 295                 300                 


Thr Val Leu Asp Gln Ala Glu Thr Ala Gly Ala Arg Leu Val Val Leu 
305                 310                 315                 320 


Ala Thr Ala Thr Pro Pro Gly Ser Val Thr Val Pro His Pro Asn Ile 
                325                 330                 335     


Glu Glu Val Ala Leu Ser Thr Thr Gly Glu Ile Pro Phe Tyr Gly Lys 
            340                 345                 350         


Ala Ile Pro Leu Glu Val Ile Lys Gly Gly Arg His Leu Ile Phe Cys 
        355                 360                 365             


His Ser Lys Lys Lys Cys Asp Glu Leu Ala Ala Lys Leu Val Ala Leu 
    370                 375                 380                 


Gly Ile Asn Ala Val Ala Tyr Tyr Arg Gly Leu Asp Val Ser Val Ile 
385                 390                 395                 400 


Pro Thr Ser Gly Asp Val Val Val Val Ala Thr Asp Ala Leu Met Thr 
                405                 410                 415     


Gly Phe Thr Gly Asp Phe Asp Ser Val Ile Asp Cys Asn Thr Cys Val 
            420                 425                 430         


Thr Gln Thr Val Asp Phe Ser Leu Asp Pro Thr Phe Thr Ile Glu Thr 
        435                 440                 445             


Thr Thr Leu Pro Gln Asp Ala Val Ser Arg Thr Gln Arg Arg Gly Arg 
    450                 455                 460                 


Thr Gly Arg Gly Lys Pro Gly Ile Tyr Arg Phe Val Ala Pro Gly Glu 
465                 470                 475                 480 


Arg Pro Ser Gly Met Phe Asp Ser Ser Val Leu Cys Glu Cys Tyr Asp 
                485                 490                 495     


Ala Gly Cys Ala Trp Tyr Glu Leu Thr Pro Ala Glu Thr Thr Val Arg 
            500                 505                 510         


Leu Arg Ala Tyr Met Asn Thr Pro Gly Leu Pro Val Cys Gln Asp His 
        515                 520                 525             


Leu Glu Phe Trp Glu Gly Val Phe Thr Gly Leu Thr His Ile Asp Ala 
    530                 535                 540                 


His Phe Leu Ser Gln Thr Lys Gln Ser Gly Glu Asn Leu Pro Tyr Leu 
545                 550                 555                 560 


Val Ala Tyr Gln Ala Thr Val Cys Ala Arg Ala Gln Ala Pro Pro Pro 
                565                 570                 575     


Ser Trp Asp Gln Met Trp Lys Cys Leu Ile Arg Leu Lys Pro Thr Leu 
            580                 585                 590         


His Gly Pro Thr Pro Leu Leu Tyr Arg Leu Gly Ala Val Gln Asn Glu 
        595                 600                 605             


Val Thr Leu Thr His Pro Ile Thr Lys Tyr Ile Met Thr Cys Met Ser 
    610                 615                 620                 


Ala Asp Leu Glu Val Val Thr Ser Thr Trp Val Leu Val Gly Gly Val 
625                 630                 635                 640 


Leu Ala Ala Leu Ala Ala Tyr Cys Leu Ser Thr Gly Cys Val Val Ile 
                645                 650                 655     


Val Gly Arg Ile Val Leu Ser Gly Lys Pro Ala Ile Ile Pro Asp Arg 
            660                 665                 670         


Glu Val Leu Tyr Arg Glu Phe Asp Glu Met Glu Glu Cys Ser Gln His 
        675                 680                 685             


Leu Pro Tyr Ile Glu Gln Gly Met Met Leu Ala Glu Gln Phe Lys Gln 
    690                 695                 700                 


Lys Ala Leu Gly Leu Leu Gln Thr Ala Ser Arg Gln Ala Glu Val Ile 
705                 710                 715                 720 


Ala Pro Ala Val Gln Thr Asn Trp Gln Lys Leu Glu Ala Phe Trp Ala 
                725                 730                 735     


Lys His Met Trp Asn Phe Ile Ser Gly Ile Gln Tyr Leu Ala Gly Leu 
            740                 745                 750         


Ser Thr Leu Pro Gly Asn Pro Ala Ile Ala Ser Leu Met Ala Phe Thr 
        755                 760                 765             


Ala Ala Val Thr Ser Pro Leu Thr Thr Ser Gln Thr Leu Leu Phe Asn 
    770                 775                 780                 


Ile Leu Gly Gly Trp Val Ala Ala Gln Leu Ala Ala Pro Gly Ala Ala 
785                 790                 795                 800 


Thr Ala Phe Val Gly Ala Gly Leu Ala Gly Ala Ala Ile Gly Ser Val 
                805                 810                 815     


Gly Leu Gly Lys Val Leu Val Asp Ile Leu Ala Gly Tyr Gly Ala Gly 
            820                 825                 830         


Val Ala Gly Ala Leu Val Ala Phe Lys Ile Met Ser Gly Glu Val Pro 
        835                 840                 845             


Ser Thr Glu Asp Leu Val Asn Leu Leu Pro Ala Ile Leu Ser Pro Gly 
    850                 855                 860                 


Ala Leu Val Val Gly Val Val Cys Ala Ala Ile Leu Arg Arg His Val 
865                 870                 875                 880 


Gly Pro Gly Glu Gly Ala Val Gln Trp Met Asn Arg Leu Ile Ala Phe 
                885                 890                 895     


Ala Ser Arg Gly Asn His Val Ser Pro Thr His Tyr Val Pro Glu Ser 
            900                 905                 910         


Asp Ala Ala Ala Arg Val Thr Ala Ile Leu Ser Ser Leu Thr Val Thr 
        915                 920                 925             


Gln Leu Leu Arg Arg Leu His Gln Trp Ile Ser Ser Glu Cys Thr Thr 
    930                 935                 940                 


Pro Cys Ser Gly Ser Trp Leu Arg Asp Ile Trp Asp Trp Ile Cys Glu 
945                 950                 955                 960 


Val Leu Ser Asp Phe Lys Thr Trp Leu Lys Ala Lys Leu Met Pro Gln 
                965                 970                 975     


Leu Pro Gly Ile Pro Phe Val Ser Cys Gln Arg Gly Tyr Arg Gly Val 
            980                 985                 990         


Trp Arg Gly Asp Gly Ile Met His  Thr Arg Cys His Cys  Gly Ala Glu 
        995                 1000                 1005             


Ile Thr  Gly His Val Lys Asn  Gly Thr Met Arg Ile  Val Gly Pro 
    1010                 1015                 1020             


Arg Thr  Cys Arg Asn Met Trp  Ser Gly Thr Phe Pro  Ile Asn Ala 
    1025                 1030                 1035             


Tyr Thr  Thr Gly Pro Cys Thr  Pro Leu Pro Ala Pro  Asn Tyr Thr 
    1040                 1045                 1050             


Phe Ala  Leu Trp Arg Val Ser  Ala Glu Glu Tyr Val  Glu Ile Arg 
    1055                 1060                 1065             


Gln Val  Gly Asp Phe His Tyr  Val Thr Gly Met Thr  Thr Asp Asn 
    1070                 1075                 1080             


Leu Lys  Cys Pro Cys Gln Val  Pro Ser Pro Glu Phe  Phe Thr Glu 
    1085                 1090                 1095             


Leu Asp  Gly Val Arg Leu His  Arg Phe Ala Pro Pro  Cys Lys Pro 
    1100                 1105                 1110             


Leu Leu  Arg Glu Glu Val Ser  Phe Arg Val Gly Leu  His Glu Tyr 
    1115                 1120                 1125             


Pro Val  Gly Ser Gln Leu Pro  Cys Glu Pro Glu Pro  Asp Val Ala 
    1130                 1135                 1140             


Val Leu  Thr Ser Met Leu Thr  Asp Pro Ser His Ile  Thr Ala Glu 
    1145                 1150                 1155             


Ala Ala  Gly Arg Arg Leu Ala  Arg Gly Ser Pro Pro  Ser Val Ala 
    1160                 1165                 1170             


Ser Ser  Ser Ala Ser Gln Leu  Ser Ala Pro Ser Leu  Lys Ala Thr 
    1175                 1180                 1185             


Cys Thr  Ala Asn His Asp Ser  Pro Asp Ala Glu Leu  Ile Glu Ala 
    1190                 1195                 1200             


Asn Leu  Leu Trp Arg Gln Glu  Met Gly Gly Asn Ile  Thr Arg Val 
    1205                 1210                 1215             


Glu Ser  Glu Asn Lys Val Val  Ile Leu Asp Ser Phe  Asp Pro Leu 
    1220                 1225                 1230             


Val Ala  Glu Glu Asp Glu Arg  Glu Ile Ser Val Pro  Ala Glu Ile 
    1235                 1240                 1245             


Leu Arg  Lys Ser Arg Arg Phe  Ala Pro Ala Leu Pro  Ile Trp Ala 
    1250                 1255                 1260             


Arg Pro  Asp Tyr Asn Pro Pro  Leu Leu Glu Thr Trp  Lys Lys Pro 
    1265                 1270                 1275             


Asp Tyr  Glu Pro Pro Val Val  His Gly Cys Pro Leu  Pro Pro Pro 
    1280                 1285                 1290             


Gln Ser  Pro Pro Val Pro Pro  Pro Arg Lys Lys Arg  Thr Val Val 
    1295                 1300                 1305             


Leu Thr  Glu Ser Thr Val Ser  Thr Ala Leu Ala Glu  Leu Ala Thr 
    1310                 1315                 1320             


Lys Ser  Phe Gly Ser Ser Ser  Thr Ser Gly Ile Thr  Gly Asp Asn 
    1325                 1330                 1335             


Thr Thr  Thr Ser Ser Glu Pro  Ala Pro Ser Gly Cys  Pro Pro Asp 
    1340                 1345                 1350             


Ser Asp  Ala Glu Ser Tyr Ser  Ser Met Pro Pro Leu  Glu Gly Glu 
    1355                 1360                 1365             


Pro Gly  Asp Pro Asp Leu Ser  Asp Gly Ser Trp Ser  Thr Val Ser 
    1370                 1375                 1380             


Ser Glu  Ala Asp Thr Glu Asp  Val Val Cys Cys Ser  Met Ser Tyr 
    1385                 1390                 1395             


Ser Trp  Thr Gly Ala Leu Val  Thr Pro Cys Ala Ala  Glu Glu Gln 
    1400                 1405                 1410             


Lys Leu  Pro Ile Asn Ala Leu  Ser Asn Ser Leu Leu  Arg His His 
    1415                 1420                 1425             


Asn Leu  Val Tyr Ser Thr Thr  Ser Arg Ser Ala Cys  Gln Arg Gln 
    1430                 1435                 1440             


Lys Lys  Val Thr Phe Asp Arg  Leu Gln Val Leu Asp  Ser His Tyr 
    1445                 1450                 1455             


Gln Asp  Val Leu Lys Glu Val  Lys Ala Ala Ala Ser  Lys Val Lys 
    1460                 1465                 1470             


Ala Asn  Leu Leu Ser Val Glu  Glu Ala Cys Ser Leu  Thr Pro Pro 
    1475                 1480                 1485             


His Ser  Ala Lys Ser Lys Phe  Gly Tyr Gly Ala Lys  Asp Val Arg 
    1490                 1495                 1500             


Cys His  Ala Arg Lys Ala Val  Asn His Ile Asn Ser  Val Trp Lys 
    1505                 1510                 1515             


Asp Leu  Leu Glu Asp Ser Val  Thr Pro Ile Asp Thr  Thr Ile Met 
    1520                 1525                 1530             


Ala Lys  Asn Glu Val Phe Cys  Val Gln Pro Glu Lys  Gly Gly Arg 
    1535                 1540                 1545             


Lys Pro  Ala Arg Leu Ile Val  Phe Pro Asp Leu Gly  Val Arg Val 
    1550                 1555                 1560             


Cys Glu  Lys Met Ala Leu Tyr  Asp Val Val Ser Lys  Leu Pro Leu 
    1565                 1570                 1575             


Ala Val  Met Gly Ser Ser Tyr  Gly Phe Gln Tyr Ser  Pro Gly Gln 
    1580                 1585                 1590             


Arg Val  Glu Phe Leu Val Gln  Ala Trp Lys Ser Lys  Lys Thr Pro 
    1595                 1600                 1605             


Met Gly  Phe Ser Tyr Asp Thr  Arg Cys Phe Asp Ser  Thr Val Thr 
    1610                 1615                 1620             


Glu Ser  Asp Ile Arg Thr Glu  Glu Ala Ile Tyr Gln  Cys Cys Asp 
    1625                 1630                 1635             


Leu Asp  Pro Gln Ala Arg Val  Ala Ile Lys Ser Leu  Thr Glu Arg 
    1640                 1645                 1650             


Leu Tyr  Val Gly Gly Pro Leu  Thr Asn Ser Arg Gly  Glu Asn Cys 
    1655                 1660                 1665             


Gly Tyr  Arg Arg Cys Arg Ala  Ser Gly Val Leu Thr  Thr Ser Cys 
    1670                 1675                 1680             


Gly Asn  Thr Leu Thr Cys Tyr  Ile Lys Ala Arg Ala  Ala Cys Arg 
    1685                 1690                 1695             


Ala Ala  Gly Leu Gln Asp Cys  Thr Met Leu Val Cys  Gly Asn Asn 
    1700                 1705                 1710             


Leu Val  Val Ile Cys Glu Ser  Ala Gly Val Gln Glu  Asp Ala Ala 
    1715                 1720                 1725             


Ser Leu  Arg Ala Phe Thr Glu  Ala Met Thr Arg Tyr  Ser Ala Pro 
    1730                 1735                 1740             


Pro Gly  Asp Pro Pro Gln Pro  Glu Tyr Asp Leu Glu  Leu Ile Thr 
    1745                 1750                 1755             


Ser Cys  Ser Ser Asn Val Ser  Val Ala His Asp Gly  Ala Gly Lys 
    1760                 1765                 1770             


Arg Val  Tyr Tyr Leu Thr Arg  Asp Pro Thr Thr Pro  Leu Ala Arg 
    1775                 1780                 1785             


Ala Ala  Trp Glu Thr Ala Arg  His Thr Pro Val Asn  Ser Trp Leu 
    1790                 1795                 1800             


Gly Asn  Ile Ile Met Phe Ala  Pro Thr Leu Trp Ala  Arg Met Ile 
    1805                 1810                 1815             


Leu Met  Thr His Phe Phe Ser  Val Leu Ile Ala Arg  Asp Gln Leu 
    1820                 1825                 1830             


Glu Gln  Ala Leu Asp Cys Glu  Ile Tyr Gly Ala Cys  Tyr Ser Ile 
    1835                 1840                 1845             


Glu Pro  Leu Asp Leu Pro Pro  Ile Ile Gln Arg Leu  His Gly Leu 
    1850                 1855                 1860             


Ser Ala  Phe Ser Leu His Ser  Tyr Ser Pro Gly Glu  Ile Asn Arg 
    1865                 1870                 1875             


Val Ala  Ala Cys Leu Arg Lys  Leu Gly Val Pro Pro  Leu Arg Ala 
    1880                 1885                 1890             


Trp Arg  His Arg Ala Arg Ser  Val Arg Ala Arg Leu  Leu Ser Arg 
    1895                 1900                 1905             


Gly Gly  Arg Ala Ala Ile Cys  Gly Lys Tyr Leu Phe  Asn Trp Ala 
    1910                 1915                 1920             


Val Arg  Thr Lys Leu Lys Leu  Thr Pro Ile Ala Ala  Ala Gly Gln 
    1925                 1930                 1935             


Leu Asp  Leu Ser Gly Trp Phe  Thr Ala Gly Tyr Ser  Gly Gly Asp 
    1940                 1945                 1950             


Ile Tyr  His Ser Val Ser His  Ala Arg Pro Arg Trp  Phe Trp Phe 
    1955                 1960                 1965             


Cys Leu  Leu Leu Leu Ala Ala  Gly Val Gly Ile Tyr  Leu Leu Pro 
    1970                 1975                 1980             


Asn Arg  
    1985 


<210>  95
<211>  3012
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Sequence


<220>
<221>  misc_feature
<222>  (3012)..(3012)
<223>  Xaa can be any amino acid

<400>  95

Met Ser Thr Asn Pro Lys Pro Gln Arg Lys Thr Lys Arg Asn Thr Asn 
1               5                   10                  15      


Arg Arg Pro Gln Asp Val Lys Phe Pro Gly Gly Gly Gln Ile Val Gly 
            20                  25                  30          


Gly Val Tyr Leu Leu Pro Arg Arg Gly Pro Arg Leu Gly Val Arg Ala 
        35                  40                  45              


Thr Arg Lys Thr Ser Glu Arg Ser Gln Pro Arg Gly Arg Arg Gln Pro 
    50                  55                  60                  


Ile Pro Lys Ala Arg Arg Pro Glu Gly Arg Thr Trp Ala Gln Pro Gly 
65                  70                  75                  80  


Tyr Pro Trp Pro Leu Tyr Gly Asn Glu Gly Cys Gly Trp Ala Gly Trp 
                85                  90                  95      


Leu Leu Ser Pro Arg Gly Ser Arg Pro Ser Trp Gly Pro Thr Asp Pro 
            100                 105                 110         


Arg Arg Arg Ser Arg Asn Leu Gly Lys Val Ile Asp Thr Leu Thr Cys 
        115                 120                 125             


Gly Phe Ala Asp Leu Met Gly Tyr Ile Pro Leu Val Gly Ala Pro Leu 
    130                 135                 140                 


Gly Gly Ala Ala Arg Ala Leu Ala His Gly Val Arg Val Leu Glu Asp 
145                 150                 155                 160 


Gly Val Asn Tyr Ala Thr Gly Asn Leu Pro Gly Cys Ser Phe Ser Ile 
                165                 170                 175     


Phe Leu Leu Ala Leu Leu Ser Cys Leu Thr Val Pro Ala Ser Ala Tyr 
            180                 185                 190         


Gln Val Arg Asn Ser Thr Gly Leu Tyr His Val Thr Asn Asp Cys Pro 
        195                 200                 205             


Asn Ser Ser Ile Val Tyr Glu Ala Ala Asp Ala Ile Leu His Thr Pro 
    210                 215                 220                 


Gly Cys Val Pro Cys Val Arg Glu Gly Asn Ala Ser Arg Cys Trp Val 
225                 230                 235                 240 


Ala Val Thr Pro Thr Val Ala Thr Arg Asp Gly Lys Leu Pro Thr Thr 
                245                 250                 255     


Gln Leu Arg Arg His Ile Asp Leu Leu Val Gly Ser Ala Thr Leu Cys 
            260                 265                 270         


Ser Ala Leu Tyr Val Gly Asp Leu Cys Gly Ser Val Phe Leu Val Gly 
        275                 280                 285             


Gln Leu Phe Thr Phe Ser Pro Arg Arg His Trp Thr Thr Gln Asp Cys 
    290                 295                 300                 


Asn Cys Ser Ile Tyr Pro Gly His Ile Thr Gly His Arg Met Ala Trp 
305                 310                 315                 320 


Asp Met Met Met Asn Trp Ser Pro Thr Thr Ala Leu Val Val Ala Gln 
                325                 330                 335     


Leu Leu Arg Ile Pro Gln Ala Ile Leu Asp Met Ile Ala Gly Ala His 
            340                 345                 350         


Trp Gly Val Leu Ala Gly Ile Ala Tyr Phe Ser Met Val Gly Asn Trp 
        355                 360                 365             


Ala Lys Val Leu Val Val Leu Leu Leu Phe Ala Gly Val Asp Ala Glu 
    370                 375                 380                 


Thr His Val Thr Gly Gly Ser Ala Ala Arg Thr Thr Ser Gly Leu Ala 
385                 390                 395                 400 


Ser Leu Phe Thr Pro Gly Ala Lys Gln Asn Ile Gln Leu Ile Asn Thr 
                405                 410                 415     


Asn Gly Ser Trp His Ile Asn Arg Thr Ala Leu Asn Cys Asn Asp Ser 
            420                 425                 430         


Leu Asn Thr Gly Trp Leu Ala Gly Leu Phe Tyr Tyr His Lys Phe Asn 
        435                 440                 445             


Ser Ser Gly Cys Pro Glu Arg Leu Ala Ser Cys Arg Pro Leu Thr Asp 
    450                 455                 460                 


Phe Asp Gln Gly Trp Gly Pro Ile Ser Tyr Ala Asn Gly Ser Gly Pro 
465                 470                 475                 480 


Asp Gln Arg Pro Tyr Cys Trp His Tyr Pro Pro Lys Pro Cys Gly Ile 
                485                 490                 495     


Val Pro Ala Lys Ser Val Cys Gly Pro Val Tyr Cys Phe Thr Pro Ser 
            500                 505                 510         


Pro Val Val Val Gly Thr Thr Asp Arg Ser Gly Ala Pro Thr Tyr Asn 
        515                 520                 525             


Trp Gly Glu Asn Asp Thr Asp Val Phe Val Leu Asn Asn Thr Arg Pro 
    530                 535                 540                 


Pro Leu Gly Asn Trp Phe Gly Cys Thr Trp Met Asn Ser Thr Gly Phe 
545                 550                 555                 560 


Thr Lys Val Cys Gly Ala Pro Pro Cys Val Ile Gly Gly Val Gly Asn 
                565                 570                 575     


Asn Thr Leu His Cys Pro Thr Asp Cys Phe Arg Lys His Pro Glu Ala 
            580                 585                 590         


Thr Tyr Ser Arg Cys Gly Ser Gly Pro Trp Ile Thr Pro Arg Cys Leu 
        595                 600                 605             


Val Asp Tyr Pro Tyr Arg Leu Trp His Tyr Pro Cys Thr Ile Asn Tyr 
    610                 615                 620                 


Thr Ile Phe Lys Val Arg Met Tyr Val Gly Gly Val Glu His Arg Leu 
625                 630                 635                 640 


Glu Ala Ala Cys Asn Trp Thr Arg Gly Glu Arg Cys Asp Leu Glu Asp 
                645                 650                 655     


Arg Asp Arg Ser Glu Leu Ser Pro Leu Leu Leu Ser Thr Thr Gln Trp 
            660                 665                 670         


Gln Val Leu Pro Cys Ser Phe Thr Thr Leu Pro Ala Leu Ser Thr Gly 
        675                 680                 685             


Leu Ile His Leu His Gln Asn Ile Val Asp Val Gln Tyr Leu Tyr Gly 
    690                 695                 700                 


Val Gly Ser Ser Ile Ala Ser Trp Ala Ile Lys Trp Glu Tyr Val Val 
705                 710                 715                 720 


Leu Leu Phe Leu Leu Leu Ala Asp Ala Arg Val Cys Ser Cys Leu Trp 
                725                 730                 735     


Met Met Leu Leu Ile Ser Gln Ala Glu Ala Ala Leu Glu Asn Leu Val 
            740                 745                 750         


Val Leu Asn Ala Ala Ser Leu Ala Gly Thr His Gly Leu Val Ser Phe 
        755                 760                 765             


Leu Val Phe Phe Cys Phe Ala Trp Tyr Leu Lys Gly Arg Trp Val Pro 
    770                 775                 780                 


Gly Ala Ala Tyr Ala Leu Tyr Gly Met Trp Pro Leu Leu Leu Leu Leu 
785                 790                 795                 800 


Leu Ala Leu Pro Gln Arg Ala Tyr Ala Leu Asp Thr Glu Val Ala Ala 
                805                 810                 815     


Ser Cys Gly Gly Val Val Leu Val Gly Leu Met Ala Leu Thr Leu Ser 
            820                 825                 830         


Pro Tyr Tyr Lys Arg Tyr Ile Ser Trp Cys Leu Trp Trp Leu Gln Tyr 
        835                 840                 845             


Phe Leu Thr Arg Val Glu Ala Gln Leu His Val Trp Val Pro Pro Leu 
    850                 855                 860                 


Asn Val Arg Gly Gly Arg Asp Ala Val Ile Leu Leu Met Cys Val Val 
865                 870                 875                 880 


His Pro Thr Leu Val Phe Asp Ile Thr Lys Leu Leu Leu Ala Val Phe 
                885                 890                 895     


Gly Pro Leu Trp Ile Leu Gln Ala Ser Leu Leu Lys Val Pro Tyr Phe 
            900                 905                 910         


Val Arg Val Gln Gly Leu Leu Arg Ile Cys Ala Leu Ala Arg Lys Met 
        915                 920                 925             


Ala Gly Gly His Tyr Val Gln Met Ala Ile Ile Lys Leu Gly Ala Leu 
    930                 935                 940                 


Thr Gly Thr Tyr Val Tyr Asn His Leu Thr Pro Leu Arg Asp Trp Ala 
945                 950                 955                 960 


His Asn Gly Leu Arg Asp Leu Ala Val Ala Val Glu Pro Val Val Phe 
                965                 970                 975     


Ser Gln Met Glu Thr Lys Leu Ile Thr Trp Gly Ala Asp Thr Ala Ala 
            980                 985                 990         


Cys Gly Asp Ile Ile Asn Gly Leu  Pro Val Ser Ala Arg  Arg Gly Arg 
        995                 1000                 1005             


Glu Ile  Leu Leu Gly Pro Ala  Asp Gly Met Val Ser  Lys Gly Trp 
    1010                 1015                 1020             


Arg Leu  Leu Ala Pro Ile Thr  Ala Tyr Ala Gln Gln  Thr Arg Gly 
    1025                 1030                 1035             


Leu Leu  Gly Cys Ile Ile Thr  Ser Leu Thr Gly Arg  Asp Lys Asn 
    1040                 1045                 1050             


Gln Val  Glu Gly Glu Val Gln  Ile Val Ser Thr Ala  Ala Gln Thr 
    1055                 1060                 1065             


Phe Leu  Ala Thr Cys Ile Asn  Gly Val Cys Trp Thr  Val Tyr His 
    1070                 1075                 1080             


Gly Ala  Gly Thr Arg Thr Ile  Ala Ser Pro Lys Gly  Pro Val Ile 
    1085                 1090                 1095             


Gln Met  Tyr Thr Asn Val Asp  Gln Asp Leu Val Gly  Trp Pro Ala 
    1100                 1105                 1110             


Pro Gln  Gly Ala Arg Ser Leu  Thr Pro Cys Thr Cys  Gly Ser Ser 
    1115                 1120                 1125             


Asp Leu  Tyr Leu Val Thr Arg  His Ala Asp Val Ile  Pro Val Arg 
    1130                 1135                 1140             


Arg Arg  Gly Asp Ser Arg Gly  Ser Leu Leu Ser Pro  Arg Pro Ile 
    1145                 1150                 1155             


Ser Tyr  Leu Lys Gly Ser Ser  Gly Gly Pro Leu Leu  Cys Pro Ala 
    1160                 1165                 1170             


Gly His  Ala Val Gly Ile Phe  Arg Ala Ala Val Cys  Thr Arg Gly 
    1175                 1180                 1185             


Val Ala  Lys Ala Val Asp Phe  Ile Pro Val Glu Asn  Leu Glu Thr 
    1190                 1195                 1200             


Thr Met  Arg Ser Pro Val Phe  Thr Asp Asn Ser Ser  Pro Pro Ala 
    1205                 1210                 1215             


Val Pro  Gln Ser Phe Gln Val  Ala His Leu His Ala  Pro Thr Gly 
    1220                 1225                 1230             


Ser Gly  Lys Ser Thr Lys Val  Pro Ala Ala Tyr Ala  Ala Gln Gly 
    1235                 1240                 1245             


Tyr Lys  Val Leu Val Leu Asn  Pro Ser Val Ala Ala  Thr Leu Gly 
    1250                 1255                 1260             


Phe Gly  Ala Tyr Met Ser Lys  Ala His Gly Ile Asp  Pro Asn Ile 
    1265                 1270                 1275             


Arg Thr  Gly Val Arg Thr Ile  Thr Thr Gly Ser Pro  Ile Thr Tyr 
    1280                 1285                 1290             


Ser Thr  Tyr Gly Lys Phe Leu  Ala Asp Gly Gly Cys  Ser Gly Gly 
    1295                 1300                 1305             


Ala Tyr  Asp Ile Ile Ile Cys  Asp Glu Cys His Ser  Thr Asp Ala 
    1310                 1315                 1320             


Thr Ser  Ile Leu Gly Ile Gly  Thr Val Leu Asp Gln  Ala Glu Thr 
    1325                 1330                 1335             


Ala Gly  Ala Arg Leu Val Val  Leu Ala Thr Ala Thr  Pro Pro Gly 
    1340                 1345                 1350             


Ser Val  Thr Val Pro His Pro  Asn Ile Glu Glu Val  Ala Leu Ser 
    1355                 1360                 1365             


Thr Thr  Gly Glu Ile Pro Phe  Tyr Gly Lys Ala Ile  Pro Leu Glu 
    1370                 1375                 1380             


Val Ile  Lys Gly Gly Arg His  Leu Ile Phe Cys His  Ser Lys Lys 
    1385                 1390                 1395             


Lys Cys  Asp Glu Leu Ala Ala  Lys Leu Val Ala Leu  Gly Ile Asn 
    1400                 1405                 1410             


Ala Val  Ala Tyr Tyr Arg Gly  Leu Asp Val Ser Val  Ile Pro Thr 
    1415                 1420                 1425             


Ser Gly  Asp Val Val Val Val  Ala Thr Asp Ala Leu  Met Thr Gly 
    1430                 1435                 1440             


Phe Thr  Gly Asp Phe Asp Ser  Val Ile Asp Cys Asn  Thr Cys Val 
    1445                 1450                 1455             


Thr Gln  Thr Val Asp Phe Ser  Leu Asp Pro Thr Phe  Thr Ile Glu 
    1460                 1465                 1470             


Thr Thr  Thr Leu Pro Gln Asp  Ala Val Ser Arg Thr  Gln Arg Arg 
    1475                 1480                 1485             


Gly Arg  Thr Gly Arg Gly Lys  Pro Gly Ile Tyr Arg  Phe Val Ala 
    1490                 1495                 1500             


Pro Gly  Glu Arg Pro Ser Gly  Met Phe Asp Ser Ser  Val Leu Cys 
    1505                 1510                 1515             


Glu Cys  Tyr Asp Ala Gly Cys  Ala Trp Tyr Glu Leu  Thr Pro Ala 
    1520                 1525                 1530             


Glu Thr  Thr Val Arg Leu Arg  Ala Tyr Met Asn Thr  Pro Gly Leu 
    1535                 1540                 1545             


Pro Val  Cys Gln Asp His Leu  Glu Phe Trp Glu Gly  Val Phe Thr 
    1550                 1555                 1560             


Gly Leu  Thr His Ile Asp Ala  His Phe Leu Ser Gln  Thr Lys Gln 
    1565                 1570                 1575             


Ser Gly  Glu Asn Leu Pro Tyr  Leu Val Ala Tyr Gln  Ala Thr Val 
    1580                 1585                 1590             


Cys Ala  Arg Ala Gln Ala Pro  Pro Pro Ser Trp Asp  Gln Met Trp 
    1595                 1600                 1605             


Lys Cys  Leu Ile Arg Leu Lys  Pro Thr Leu His Gly  Pro Thr Pro 
    1610                 1615                 1620             


Leu Leu  Tyr Arg Leu Gly Ala  Val Gln Asn Glu Val  Thr Leu Thr 
    1625                 1630                 1635             


His Pro  Ile Thr Lys Tyr Ile  Met Thr Cys Met Ser  Ala Asp Leu 
    1640                 1645                 1650             


Glu Val  Val Thr Ser Thr Trp  Val Leu Val Gly Gly  Val Leu Ala 
    1655                 1660                 1665             


Ala Leu  Ala Ala Tyr Cys Leu  Ser Thr Gly Cys Val  Val Ile Val 
    1670                 1675                 1680             


Gly Arg  Ile Val Leu Ser Gly  Lys Pro Ala Ile Ile  Pro Asp Arg 
    1685                 1690                 1695             


Glu Val  Leu Tyr Arg Glu Phe  Asp Glu Met Glu Glu  Cys Ser Gln 
    1700                 1705                 1710             


His Leu  Pro Tyr Ile Glu Gln  Gly Met Met Leu Ala  Glu Gln Phe 
    1715                 1720                 1725             


Lys Gln  Lys Ala Leu Gly Leu  Leu Gln Thr Ala Ser  Arg Gln Ala 
    1730                 1735                 1740             


Glu Val  Ile Ala Pro Ala Val  Gln Thr Asn Trp Gln  Lys Leu Glu 
    1745                 1750                 1755             


Ala Phe  Trp Ala Lys His Met  Trp Asn Phe Ile Ser  Gly Ile Gln 
    1760                 1765                 1770             


Tyr Leu  Ala Gly Leu Ser Thr  Leu Pro Gly Asn Pro  Ala Ile Ala 
    1775                 1780                 1785             


Ser Leu  Met Ala Phe Thr Ala  Ala Val Thr Ser Pro  Leu Thr Thr 
    1790                 1795                 1800             


Ser Gln  Thr Leu Leu Phe Asn  Ile Leu Gly Gly Trp  Val Ala Ala 
    1805                 1810                 1815             


Gln Leu  Ala Ala Pro Gly Ala  Ala Thr Ala Phe Val  Gly Ala Gly 
    1820                 1825                 1830             


Leu Ala  Gly Ala Ala Ile Gly  Ser Val Gly Leu Gly  Lys Val Leu 
    1835                 1840                 1845             


Val Asp  Ile Leu Ala Gly Tyr  Gly Ala Gly Val Ala  Gly Ala Leu 
    1850                 1855                 1860             


Val Ala  Phe Lys Ile Met Ser  Gly Glu Val Pro Ser  Thr Glu Asp 
    1865                 1870                 1875             


Leu Val  Asn Leu Leu Pro Ala  Ile Leu Ser Pro Gly  Ala Leu Val 
    1880                 1885                 1890             


Val Gly  Val Val Cys Ala Ala  Ile Leu Arg Arg His  Val Gly Pro 
    1895                 1900                 1905             


Gly Glu  Gly Ala Val Gln Trp  Met Asn Arg Leu Ile  Ala Phe Ala 
    1910                 1915                 1920             


Ser Arg  Gly Asn His Val Ser  Pro Thr His Tyr Val  Pro Glu Ser 
    1925                 1930                 1935             


Asp Ala  Ala Ala Arg Val Thr  Ala Ile Leu Ser Ser  Leu Thr Val 
    1940                 1945                 1950             


Thr Gln  Leu Leu Arg Arg Leu  His Gln Trp Ile Ser  Ser Glu Cys 
    1955                 1960                 1965             


Thr Thr  Pro Cys Ser Gly Ser  Trp Leu Arg Asp Ile  Trp Asp Trp 
    1970                 1975                 1980             


Ile Cys  Glu Val Leu Ser Asp  Phe Lys Thr Trp Leu  Lys Ala Lys 
    1985                 1990                 1995             


Leu Met  Pro Gln Leu Pro Gly  Ile Pro Phe Val Ser  Cys Gln Arg 
    2000                 2005                 2010             


Gly Tyr  Arg Gly Val Trp Arg  Gly Asp Gly Ile Met  His Thr Arg 
    2015                 2020                 2025             


Cys His  Cys Gly Ala Glu Ile  Thr Gly His Val Lys  Asn Gly Thr 
    2030                 2035                 2040             


Met Arg  Ile Val Gly Pro Arg  Thr Cys Arg Asn Met  Trp Ser Gly 
    2045                 2050                 2055             


Thr Phe  Pro Ile Asn Ala Tyr  Thr Thr Gly Pro Cys  Thr Pro Leu 
    2060                 2065                 2070             


Pro Ala  Pro Asn Tyr Thr Phe  Ala Leu Trp Arg Val  Ser Ala Glu 
    2075                 2080                 2085             


Glu Tyr  Val Glu Ile Arg Gln  Val Gly Asp Phe His  Tyr Val Thr 
    2090                 2095                 2100             


Gly Met  Thr Thr Asp Asn Leu  Lys Cys Pro Cys Gln  Val Pro Ser 
    2105                 2110                 2115             


Pro Glu  Phe Phe Thr Glu Leu  Asp Gly Val Arg Leu  His Arg Phe 
    2120                 2125                 2130             


Ala Pro  Pro Cys Lys Pro Leu  Leu Arg Glu Glu Val  Ser Phe Arg 
    2135                 2140                 2145             


Val Gly  Leu His Glu Tyr Pro  Val Gly Ser Gln Leu  Pro Cys Glu 
    2150                 2155                 2160             


Pro Glu  Pro Asp Val Ala Val  Leu Thr Ser Met Leu  Thr Asp Pro 
    2165                 2170                 2175             


Ser His  Ile Thr Ala Glu Ala  Ala Gly Arg Arg Leu  Ala Arg Gly 
    2180                 2185                 2190             


Ser Pro  Pro Ser Val Ala Ser  Ser Ser Ala Ser Gln  Leu Ser Ala 
    2195                 2200                 2205             


Pro Ser  Leu Lys Ala Thr Cys  Thr Ala Asn His Asp  Ser Pro Asp 
    2210                 2215                 2220             


Ala Glu  Leu Ile Glu Ala Asn  Leu Leu Trp Arg Gln  Glu Met Gly 
    2225                 2230                 2235             


Gly Asn  Ile Thr Arg Val Glu  Ser Glu Asn Lys Val  Val Ile Leu 
    2240                 2245                 2250             


Asp Ser  Phe Asp Pro Leu Val  Ala Glu Glu Asp Glu  Arg Glu Ile 
    2255                 2260                 2265             


Ser Val  Pro Ala Glu Ile Leu  Arg Lys Ser Arg Arg  Phe Ala Pro 
    2270                 2275                 2280             


Ala Leu  Pro Ile Trp Ala Arg  Pro Asp Tyr Asn Pro  Pro Leu Leu 
    2285                 2290                 2295             


Glu Thr  Trp Lys Lys Pro Asp  Tyr Glu Pro Pro Val  Val His Gly 
    2300                 2305                 2310             


Cys Pro  Leu Pro Pro Pro Gln  Ser Pro Pro Val Pro  Pro Pro Arg 
    2315                 2320                 2325             


Lys Lys  Arg Thr Val Val Leu  Thr Glu Ser Thr Val  Ser Thr Ala 
    2330                 2335                 2340             


Leu Ala  Glu Leu Ala Thr Lys  Ser Phe Gly Ser Ser  Ser Thr Ser 
    2345                 2350                 2355             


Gly Ile  Thr Gly Asp Asn Thr  Thr Thr Ser Ser Glu  Pro Ala Pro 
    2360                 2365                 2370             


Ser Gly  Cys Pro Pro Asp Ser  Asp Ala Glu Ser Tyr  Ser Ser Met 
    2375                 2380                 2385             


Pro Pro  Leu Glu Gly Glu Pro  Gly Asp Pro Asp Leu  Ser Asp Gly 
    2390                 2395                 2400             


Ser Trp  Ser Thr Val Ser Ser  Glu Ala Asp Thr Glu  Asp Val Val 
    2405                 2410                 2415             


Cys Cys  Ser Met Ser Tyr Ser  Trp Thr Gly Ala Leu  Val Thr Pro 
    2420                 2425                 2430             


Cys Ala  Ala Glu Glu Gln Lys  Leu Pro Ile Asn Ala  Leu Ser Asn 
    2435                 2440                 2445             


Ser Leu  Leu Arg His His Asn  Leu Val Tyr Ser Thr  Thr Ser Arg 
    2450                 2455                 2460             


Ser Ala  Cys Gln Arg Gln Lys  Lys Val Thr Phe Asp  Arg Leu Gln 
    2465                 2470                 2475             


Val Leu  Asp Ser His Tyr Gln  Asp Val Leu Lys Glu  Val Lys Ala 
    2480                 2485                 2490             


Ala Ala  Ser Lys Val Lys Ala  Asn Leu Leu Ser Val  Glu Glu Ala 
    2495                 2500                 2505             


Cys Ser  Leu Thr Pro Pro His  Ser Ala Lys Ser Lys  Phe Gly Tyr 
    2510                 2515                 2520             


Gly Ala  Lys Asp Val Arg Cys  His Ala Arg Lys Ala  Val Asn His 
    2525                 2530                 2535             


Ile Asn  Ser Val Trp Lys Asp  Leu Leu Glu Asp Ser  Val Thr Pro 
    2540                 2545                 2550             


Ile Asp  Thr Thr Ile Met Ala  Lys Asn Glu Val Phe  Cys Val Gln 
    2555                 2560                 2565             


Pro Glu  Lys Gly Gly Arg Lys  Pro Ala Arg Leu Ile  Val Phe Pro 
    2570                 2575                 2580             


Asp Leu  Gly Val Arg Val Cys  Glu Lys Met Ala Leu  Tyr Asp Val 
    2585                 2590                 2595             


Val Ser  Lys Leu Pro Leu Ala  Val Met Gly Ser Ser  Tyr Gly Phe 
    2600                 2605                 2610             


Gln Tyr  Ser Pro Gly Gln Arg  Val Glu Phe Leu Val  Gln Ala Trp 
    2615                 2620                 2625             


Lys Ser  Lys Lys Thr Pro Met  Gly Phe Ser Tyr Asp  Thr Arg Cys 
    2630                 2635                 2640             


Phe Asp  Ser Thr Val Thr Glu  Ser Asp Ile Arg Thr  Glu Glu Ala 
    2645                 2650                 2655             


Ile Tyr  Gln Cys Cys Asp Leu  Asp Pro Gln Ala Arg  Val Ala Ile 
    2660                 2665                 2670             


Lys Ser  Leu Thr Glu Arg Leu  Tyr Val Gly Gly Pro  Leu Thr Asn 
    2675                 2680                 2685             


Ser Arg  Gly Glu Asn Cys Gly  Tyr Arg Arg Cys Arg  Ala Ser Gly 
    2690                 2695                 2700             


Val Leu  Thr Thr Ser Cys Gly  Asn Thr Leu Thr Cys  Tyr Ile Lys 
    2705                 2710                 2715             


Ala Arg  Ala Ala Cys Arg Ala  Ala Gly Leu Gln Asp  Cys Thr Met 
    2720                 2725                 2730             


Leu Val  Cys Gly Asp Asp Leu  Val Val Ile Cys Glu  Ser Ala Gly 
    2735                 2740                 2745             


Val Gln  Glu Asp Ala Ala Ser  Leu Arg Ala Phe Thr  Glu Ala Met 
    2750                 2755                 2760             


Thr Arg  Tyr Ser Ala Pro Pro  Gly Asp Pro Pro Gln  Pro Glu Tyr 
    2765                 2770                 2775             


Asp Leu  Glu Leu Ile Thr Ser  Cys Ser Ser Asn Val  Ser Val Ala 
    2780                 2785                 2790             


His Asp  Gly Ala Gly Lys Arg  Val Tyr Tyr Leu Thr  Arg Asp Pro 
    2795                 2800                 2805             


Thr Thr  Pro Leu Ala Arg Ala  Ala Trp Glu Thr Ala  Arg His Thr 
    2810                 2815                 2820             


Pro Val  Asn Ser Trp Leu Gly  Asn Ile Ile Met Phe  Ala Pro Thr 
    2825                 2830                 2835             


Leu Trp  Ala Arg Met Ile Leu  Met Thr His Phe Phe  Ser Val Leu 
    2840                 2845                 2850             


Ile Ala  Arg Asp Gln Leu Glu  Gln Ala Leu Asp Cys  Glu Ile Tyr 
    2855                 2860                 2865             


Gly Ala  Cys Tyr Ser Ile Glu  Pro Leu Asp Leu Pro  Pro Ile Ile 
    2870                 2875                 2880             


Gln Arg  Leu His Gly Leu Ser  Ala Phe Ser Leu His  Ser Tyr Ser 
    2885                 2890                 2895             


Pro Gly  Glu Ile Asn Arg Val  Ala Ala Cys Leu Arg  Lys Leu Gly 
    2900                 2905                 2910             


Val Pro  Pro Leu Arg Ala Trp  Arg His Arg Ala Arg  Ser Val Arg 
    2915                 2920                 2925             


Ala Arg  Leu Leu Ser Arg Gly  Gly Arg Ala Ala Ile  Cys Gly Lys 
    2930                 2935                 2940             


Tyr Leu  Phe Asn Trp Ala Val  Arg Thr Lys Leu Lys  Leu Thr Pro 
    2945                 2950                 2955             


Ile Ala  Ala Ala Gly Gln Leu  Asp Leu Ser Gly Trp  Phe Thr Ala 
    2960                 2965                 2970             


Gly Tyr  Ser Gly Gly Asp Ile  Tyr His Ser Val Ser  His Ala Arg 
    2975                 2980                 2985             


Pro Arg  Trp Phe Trp Phe Cys  Leu Leu Leu Leu Ala  Ala Gly Val 
    2990                 2995                 3000             


Gly Ile  Tyr Leu Leu Pro Asn  Arg Xaa 
    3005                 3010         


<210>  96
<211>  3014
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic Sequence


<220>
<221>  misc_feature
<222>  (197)..(197)
<223>  Xaa can be any amino acid

<220>
<221>  misc_feature
<222>  (241)..(241)
<223>  Xaa can be any amino acid

<220>
<221>  misc_feature
<222>  (251)..(251)
<223>  Xaa can be any amino acid

<220>
<221>  misc_feature
<222>  (290)..(290)
<223>  Xaa can be any amino acid

<220>
<221>  misc_feature
<222>  (331)..(331)
<223>  Xaa can be any amino acid

<220>
<221>  misc_feature
<222>  (334)..(334)
<223>  Xaa can be any amino acid

<220>
<221>  misc_feature
<222>  (343)..(344)
<223>  Xaa can be any amino acid

<220>
<221>  misc_feature
<222>  (372)..(372)
<223>  Xaa can be any amino acid

<220>
<221>  misc_feature
<222>  (390)..(390)
<223>  Xaa can be any amino acid

<220>
<221>  misc_feature
<222>  (407)..(407)
<223>  Xaa can be any amino acid

<220>
<221>  misc_feature
<222>  (433)..(433)
<223>  Xaa can be any amino acid

<220>
<221>  misc_feature
<222>  (476)..(476)
<223>  Xaa can be any amino acid

<220>
<221>  misc_feature
<222>  (523)..(523)
<223>  Xaa can be any amino acid

<220>
<221>  misc_feature
<222>  (597)..(597)
<223>  Xaa can be any amino acid

<220>
<221>  misc_feature
<222>  (715)..(715)
<223>  Xaa can be any amino acid

<220>
<221>  misc_feature
<222>  (767)..(767)
<223>  Xaa can be any amino acid

<220>
<221>  misc_feature
<222>  (786)..(786)
<223>  Xaa can be any amino acid

<220>
<221>  misc_feature
<222>  (792)..(792)
<223>  Xaa can be any amino acid

<220>
<221>  misc_feature
<222>  (821)..(821)
<223>  Xaa can be any amino acid

<220>
<221>  misc_feature
<222>  (826)..(826)
<223>  Xaa can be any amino acid

<220>
<221>  misc_feature
<222>  (843)..(843)
<223>  Xaa can be any amino acid

<220>
<221>  misc_feature
<222>  (857)..(857)
<223>  Xaa can be any amino acid

<220>
<221>  misc_feature
<222>  (873)..(874)
<223>  Xaa can be any amino acid

<220>
<221>  misc_feature
<222>  (884)..(884)
<223>  Xaa can be any amino acid

<220>
<221>  misc_feature
<222>  (922)..(922)
<223>  Xaa can be any amino acid

<220>
<221>  misc_feature
<222>  (928)..(928)
<223>  Xaa can be any amino acid

<220>
<221>  misc_feature
<222>  (955)..(955)
<223>  Xaa can be any amino acid

<220>
<221>  misc_feature
<222>  (1020)..(1020)
<223>  Xaa can be any namino acid

<220>
<221>  misc_feature
<222>  (1099)..(1099)
<223>  Xaa can be any amino acid

<220>
<221>  misc_feature
<222>  (1143)..(1143)
<223>  Xaa can be any amino acid

<220>
<221>  misc_feature
<222>  (1161)..(1161)
<223>  Xaa can be any amino acid

<220>
<221>  misc_feature
<222>  (1210)..(1210)
<223>  Xaa can be any amino acid

<220>
<221>  misc_feature
<222>  (1223)..(1223)
<223>  Xaa can be any amino acid

<220>
<221>  misc_feature
<222>  (1371)..(1371)
<223>  Xaa can be any amino acid

<220>
<221>  misc_feature
<222>  (1385)..(1385)
<223>  Xaa can be any amino acid

<220>
<221>  misc_feature
<222>  (1409)..(1409)
<223>  Xaa can be any amino acid

<220>
<221>  misc_feature
<222>  (1599)..(1599)
<223>  Xaa can be any amino acid

<220>
<221>  misc_feature
<222>  (1607)..(1607)
<223>  Xaa can be any amino acid

<220>
<221>  misc_feature
<222>  (1695)..(1695)
<223>  Xaa can be any amino acid

<220>
<221>  misc_feature
<222>  (1753)..(1753)
<223>  Xaa can be any amino acid

<220>
<221>  misc_feature
<222>  (1874)..(1874)
<223>  Xaa can be any amino acid

<220>
<221>  misc_feature
<222>  (2071)..(2072)
<223>  Xaa can be any amino acid

<220>
<221>  misc_feature
<222>  (2074)..(2074)
<223>  Xaa can be any amino acid

<220>
<221>  misc_feature
<222>  (2087)..(2087)
<223>  Xaa can be any amino acid

<220>
<221>  misc_feature
<222>  (2106)..(2106)
<223>  Xaa can be any amino acid

<220>
<221>  misc_feature
<222>  (2134)..(2134)
<223>  Xaa can be any amino acid

<220>
<221>  misc_feature
<222>  (2279)..(2279)
<223>  Xaa can be any amino acid

<220>
<221>  misc_feature
<222>  (2321)..(2321)
<223>  Xaa can be any amino acid

<220>
<221>  misc_feature
<222>  (2335)..(2335)
<223>  Xaa can be any amino acid

<220>
<221>  misc_feature
<222>  (2358)..(2358)
<223>  Xaa can be any amino acid

<220>
<221>  misc_feature
<222>  (2361)..(2362)
<223>  Xaa can be any amino acid

<220>
<221>  misc_feature
<222>  (2364)..(2364)
<223>  Xaa can be any amino acid

<220>
<221>  misc_feature
<222>  (2367)..(2367)
<223>  Xaa can be any amino acid

<220>
<221>  misc_feature
<222>  (2373)..(2374)
<223>  Xaa can be any amino acid

<220>
<221>  misc_feature
<222>  (2376)..(2376)
<223>  Xaa can be any amino acid

<220>
<221>  misc_feature
<222>  (2383)..(2383)
<223>  Xaa can be any amino acid

<220>
<221>  misc_feature
<222>  (2487)..(2487)
<223>  Xaa can be any amino acid

<220>
<221>  misc_feature
<222>  (2496)..(2496)
<223>  Xaa can be any amino acid

<220>
<221>  misc_feature
<222>  (2542)..(2542)
<223>  Xaa can be any amino acid

<220>
<221>  misc_feature
<222>  (2546)..(2546)
<223>  Xaa can be any amino acid

<220>
<221>  misc_feature
<222>  (2572)..(2572)
<223>  Xaa can be any amino acid

<220>
<221>  misc_feature
<222>  (2601)..(2601)
<223>  Xaa can be any amino acid

<220>
<221>  misc_feature
<222>  (2653)..(2653)
<223>  Xaa can be any amino acid

<220>
<221>  misc_feature
<222>  (2660)..(2660)
<223>  Xaa can be any amino acid

<220>
<221>  misc_feature
<222>  (2676)..(2676)
<223>  Xaa can be any amino acid

<220>
<221>  misc_feature
<222>  (2689)..(2689)
<223>  Xaa can be any amino acid

<220>
<221>  misc_feature
<222>  (2695)..(2695)
<223>  Xaa can be any amino acid

<220>
<221>  misc_feature
<222>  (2722)..(2722)
<223>  Xaa can be any amino acid

<220>
<221>  misc_feature
<222>  (2757)..(2757)
<223>  Xaa can be any amino acid

<220>
<221>  misc_feature
<222>  (2798)..(2798)
<223>  Xaa can be any amino acid

<220>
<221>  misc_feature
<222>  (2857)..(2857)
<223>  Xaa can be any amino acid

<220>
<221>  misc_feature
<222>  (2863)..(2863)
<223>  Xaa can be any amino acid

<220>
<221>  misc_feature
<222>  (2966)..(2966)
<223>  Xaa can be any amino acid

<220>
<221>  misc_feature
<222>  (3002)..(3002)
<223>  Xaa can be any amino acid

<220>
<221>  misc_feature
<222>  (3014)..(3014)
<223>  Xaa can be any amino acid

<400>  96

Met Ser Thr Asn Pro Lys Pro Gln Arg Lys Thr Lys Arg Asn Thr Asn 
1               5                   10                  15      


Arg Arg Pro Gln Asp Val Lys Phe Pro Gly Gly Gly Gln Ile Val Gly 
            20                  25                  30          


Gly Val Tyr Leu Leu Pro Arg Arg Gly Pro Arg Leu Gly Val Arg Ala 
        35                  40                  45              


Thr Arg Lys Thr Ser Glu Arg Ser Gln Pro Arg Gly Arg Arg Gln Pro 
    50                  55                  60                  


Ile Pro Lys Ala Arg Arg Ser Glu Gly Arg Ser Trp Ala Gln Pro Gly 
65                  70                  75                  80  


Tyr Pro Trp Pro Leu Tyr Gly Asn Glu Gly Cys Gly Trp Ala Gly Trp 
                85                  90                  95      


Leu Leu Ser Pro Arg Gly Ser Arg Pro Ser Trp Gly Pro Thr Asp Pro 
            100                 105                 110         


Arg Arg Arg Ser Arg Asn Leu Gly Lys Val Ile Asp Thr Leu Thr Cys 
        115                 120                 125             


Gly Phe Ala Asp Leu Met Gly Tyr Ile Pro Leu Val Gly Ala Pro Leu 
    130                 135                 140                 


Gly Gly Val Ala Arg Ala Leu Ala His Gly Val Arg Val Leu Glu Asp 
145                 150                 155                 160 


Gly Ile Asn Tyr Ala Thr Gly Asn Leu Pro Gly Cys Ser Phe Ser Ile 
                165                 170                 175     


Phe Leu Leu Ala Leu Leu Ser Cys Leu Thr Val Pro Ala Ser Ala Tyr 
            180                 185                 190         


Glu Val Arg Asn Xaa Ser Gly Leu Tyr His Val Thr Asn Asp Cys Pro 
        195                 200                 205             


Asn Ser Ser Ile Val Tyr Glu Ala Asp Asp Ala Ile Leu His Thr Pro 
    210                 215                 220                 


Gly Cys Val Pro Cys Val Arg Glu Gly Asn Thr Ser Arg Cys Trp Val 
225                 230                 235                 240 


Xaa Val Thr Pro Thr Val Ala Val Arg Tyr Xaa Gly Ala Pro Thr Thr 
                245                 250                 255     


Ser Leu Arg Arg His Val Asp Leu Leu Val Gly Ala Ala Thr Leu Cys 
            260                 265                 270         


Ser Ala Leu Tyr Val Gly Asp Leu Cys Gly Ala Val Phe Leu Val Gly 
        275                 280                 285             


Gln Xaa Phe Thr Phe Ser Pro Arg Arg His Trp Thr Val Gln Asp Cys 
    290                 295                 300                 


Asn Cys Ser Ile Tyr Pro Gly His Ile Thr Gly His Arg Met Ala Trp 
305                 310                 315                 320 


Asp Met Met Met Asn Trp Ser Pro Thr Thr Xaa Leu Val Xaa Ala Gln 
                325                 330                 335     


Leu Leu Arg Ile Pro Gln Xaa Xaa Leu Asp Ile Ile Ala Gly Ala His 
            340                 345                 350         


Trp Gly Val Leu Ala Gly Leu Ala Tyr Phe Ser Met Gln Gly Asn Trp 
        355                 360                 365             


Ala Lys Val Xaa Val Leu Leu Leu Phe Ala Gly Val Asp Ala Glu Thr 
    370                 375                 380                 


His Thr Thr Gly Gly Xaa Ala Ala Arg Thr Thr Ser Gly Leu Thr Ser 
385                 390                 395                 400 


Leu Phe Ser Pro Gly Pro Xaa Gln Asn Leu Gln Leu Ile Asn Thr Asn 
                405                 410                 415     


Gly Ser Trp His Ile Asn Arg Thr Ala Leu Asn Cys Asn Asp Ser Leu 
            420                 425                 430         


Xaa Thr Gly Phe Ile Ala Gly Leu Phe Tyr Thr His Lys Phe Asn Ser 
        435                 440                 445             


Ser Gly Cys Pro Glu Arg Leu Ala Ser Cys Arg Pro Leu Thr Asp Phe 
    450                 455                 460                 


Asp Gln Gly Trp Gly Pro Leu Thr Tyr Ala Asn Xaa Ile Ser Gly Pro 
465                 470                 475                 480 


Ser Asp Asp Arg Pro Tyr Cys Trp His Tyr Pro Pro Arg Pro Cys Gly 
                485                 490                 495     


Ile Val Pro Ala Arg Ser Val Cys Gly Pro Val Tyr Cys Phe Thr Pro 
            500                 505                 510         


Ser Pro Val Val Val Gly Thr Thr Asp Arg Xaa Gly Val Pro Thr Tyr 
        515                 520                 525             


Thr Trp Gly Glu Asn Glu Thr Asp Val Phe Leu Leu Asn Ser Thr Arg 
    530                 535                 540                 


Pro Pro Gln Gly Asn Trp Phe Gly Cys Thr Trp Met Asn Ser Thr Gly 
545                 550                 555                 560 


Phe Thr Lys Thr Cys Gly Ala Pro Pro Cys Asn Ile Gly Gly Gly Gly 
                565                 570                 575     


Asn Asn Asp Leu Leu Cys Pro Thr Asp Cys Phe Arg Lys His Pro Glu 
            580                 585                 590         


Ala Thr Tyr Ser Xaa Cys Gly Ser Gly Pro Trp Leu Thr Pro Arg Cys 
        595                 600                 605             


Leu Val Asp Tyr Pro Tyr Arg Leu Trp His Tyr Pro Cys Thr Val Asn 
    610                 615                 620                 


Phe Thr Ile Phe Lys Val Arg Met Tyr Val Gly Gly Val Glu His Arg 
625                 630                 635                 640 


Leu Glu Ala Ala Cys Asn Trp Thr Arg Gly Glu Arg Cys Asp Leu Glu 
                645                 650                 655     


Asp Arg Asp Arg Ser Glu Leu Ser Pro Leu Leu His Ser Thr Thr Glu 
            660                 665                 670         


Trp Ala Ile Leu Pro Cys Ser Phe Thr Thr Leu Pro Ala Leu Ser Thr 
        675                 680                 685             


Gly Leu Ile His Leu His Gln Asn Ile Val Asp Val Gln Tyr Leu Tyr 
    690                 695                 700                 


Gly Val Gly Ser Ala Val Val Ser Trp Ala Xaa Lys Trp Glu Tyr Val 
705                 710                 715                 720 


Val Leu Leu Phe Leu Leu Leu Ala Asp Ala Arg Val Cys Ala Cys Leu 
                725                 730                 735     


Trp Met Met Leu Leu Ile Ser Gln Ala Glu Ala Ala Leu Glu Asn Leu 
            740                 745                 750         


Val Val Leu Asn Ala Ala Ser Ala Ala Gly Thr His Gly Ile Xaa Trp 
        755                 760                 765             


Phe Leu Val Phe Phe Cys Ala Ala Trp Tyr Leu Lys Gly Arg Leu Val 
    770                 775                 780                 


Pro Xaa Ala Thr Tyr Ala Leu Xaa Gly Leu Trp Pro Leu Leu Leu Leu 
785                 790                 795                 800 


Leu Leu Ala Leu Pro Gln Arg Ala Tyr Ala Leu Asp Arg Glu Val Ala 
                805                 810                 815     


Ala Ser Leu Gly Xaa Ala Val Leu Val Xaa Leu Thr Ile Phe Thr Leu 
            820                 825                 830         


Ser Pro His Tyr Lys His Leu Leu Ser Arg Xaa Leu Trp Trp Leu Gln 
        835                 840                 845             


Tyr Phe Ile Thr Arg Ala Glu Ala Xaa Leu Gln Val Trp Val Pro Pro 
    850                 855                 860                 


Leu Asn Val Arg Gly Gly Arg Asp Xaa Xaa Ile Leu Leu Thr Cys Leu 
865                 870                 875                 880 


Leu His Pro Xaa Leu Val Phe Asp Ile Thr Lys Leu Leu Leu Ala Val 
                885                 890                 895     


Leu Gly Pro Leu Tyr Leu Leu Gln Ala Ser Leu Leu Arg Val Pro Tyr 
            900                 905                 910         


Phe Val Arg Ala His Ala Leu Leu Arg Xaa Cys Met Leu Val Arg Xaa 
        915                 920                 925             


Leu Ala Gly Gly Lys Tyr Val Gln Met Ala Leu Leu Lys Leu Gly Arg 
    930                 935                 940                 


Trp Thr Gly Thr Tyr Ile Tyr Asp His Leu Xaa Pro Leu Ser Asp Trp 
945                 950                 955                 960 


Ala Ala Ala Gly Leu Arg Asp Leu Ala Val Ala Val Glu Pro Val Ile 
                965                 970                 975     


Phe Ser Pro Met Glu Lys Lys Val Ile Thr Trp Gly Ala Asp Thr Ala 
            980                 985                 990         


Ala Cys Gly Asp Ile Leu Cys Gly  Leu Pro Val Ser Ala  Arg Leu Gly 
        995                 1000                 1005             


Arg Glu  Ile Leu Leu Gly Pro  Ala Asp Asp Tyr Xaa  Ser Lys Gly 
    1010                 1015                 1020             


Trp Arg  Leu Leu Ala Pro Ile  Thr Ala Tyr Ala Gln  Gln Thr Arg 
    1025                 1030                 1035             


Gly Leu  Leu Gly Thr Ile Val  Thr Ser Leu Thr Gly  Arg Asp Lys 
    1040                 1045                 1050             


Asn Glu  Val Glu Gly Glu Val  Gln Val Leu Ser Thr  Ala Thr Gln 
    1055                 1060                 1065             


Thr Phe  Leu Gly Thr Cys Ile  Asn Gly Val Met Trp  Thr Val Tyr 
    1070                 1075                 1080             


His Gly  Ala Gly Ser Lys Thr  Leu Ala Gly Pro Lys  Gly Pro Val 
    1085                 1090                 1095             


Xaa Gln  Met Tyr Thr Asn Val  Asp Gln Asp Leu Val  Gly Trp Pro 
    1100                 1105                 1110             


Ala Pro  Pro Gly Ala Lys Ser  Leu Thr Pro Cys Thr  Cys Gly Ser 
    1115                 1120                 1125             


Ser Asp  Leu Tyr Leu Val Thr  Arg His Ala Asp Val  Ile Pro Xaa 
    1130                 1135                 1140             


Arg Arg  Arg Gly Asp Ser Arg  Gly Ser Leu Leu Ser  Pro Arg Pro 
    1145                 1150                 1155             


Ile Ser  Xaa Leu Lys Gly Ser  Ser Gly Gly Pro Val  Leu Cys Pro 
    1160                 1165                 1170             


Ser Gly  His Ala Val Gly Ile  Phe Arg Ala Ala Val  Cys Thr Arg 
    1175                 1180                 1185             


Gly Val  Ala Lys Ala Val Asp  Phe Ile Pro Val Glu  Ser Leu Glu 
    1190                 1195                 1200             


Thr Thr  Met Arg Ser Pro Xaa  Phe Thr Asp Asn Ser  Thr Pro Pro 
    1205                 1210                 1215             


Ala Val  Pro Gln Xaa Tyr Gln  Val Gly Tyr Leu His  Ala Pro Thr 
    1220                 1225                 1230             


Gly Ser  Gly Lys Ser Thr Lys  Val Pro Ala Ala Tyr  Ala Ala Gln 
    1235                 1240                 1245             


Gly Tyr  Lys Val Leu Val Leu  Asn Pro Ser Val Ala  Ala Thr Leu 
    1250                 1255                 1260             


Gly Phe  Gly Ala Tyr Met Ser  Lys Ala His Gly Ile  Asp Pro Asn 
    1265                 1270                 1275             


Ile Arg  Thr Gly Val Arg Thr  Val Thr Thr Gly Ala  Pro Ile Thr 
    1280                 1285                 1290             


Tyr Ser  Thr Tyr Gly Lys Phe  Leu Ala Asp Gly Gly  Cys Ser Gly 
    1295                 1300                 1305             


Gly Ala  Tyr Asp Ile Ile Ile  Cys Asp Glu Cys His  Ser Thr Asp 
    1310                 1315                 1320             


Ala Thr  Thr Ile Leu Gly Ile  Gly Thr Val Leu Asp  Gln Ala Glu 
    1325                 1330                 1335             


Thr Ala  Gly Val Arg Leu Val  Val Leu Ala Thr Ala  Thr Pro Pro 
    1340                 1345                 1350             


Gly Ser  Val Thr Val Pro His  Pro Asn Ile Glu Glu  Val Ala Leu 
    1355                 1360                 1365             


Gly Thr  Xaa Gly Glu Ile Pro  Phe Tyr Gly Lys Ala  Ile Pro Leu 
    1370                 1375                 1380             


Glu Xaa  Ile Lys Gly Gly Arg  His Leu Ile Phe Cys  His Ser Lys 
    1385                 1390                 1395             


Lys Lys  Cys Asp Glu Leu Ala  Ala Lys Leu Xaa Gly  Leu Gly Leu 
    1400                 1405                 1410             


Asn Ala  Val Ala Tyr Tyr Arg  Gly Leu Asp Val Ser  Val Ile Pro 
    1415                 1420                 1425             


Thr Ser  Gly Asp Val Val Val  Val Ala Thr Asp Ala  Leu Met Thr 
    1430                 1435                 1440             


Gly Phe  Thr Gly Asp Phe Asp  Ser Val Ile Asp Cys  Asn Val Ala 
    1445                 1450                 1455             


Val Thr  Gln Thr Val Asp Phe  Ser Leu Asp Pro Thr  Phe Thr Ile 
    1460                 1465                 1470             


Glu Thr  Thr Thr Val Pro Gln  Asp Ala Val Ser Arg  Ser Gln Arg 
    1475                 1480                 1485             


Arg Gly  Arg Thr Gly Arg Gly  Arg Leu Gly Ile Tyr  Arg Tyr Val 
    1490                 1495                 1500             


Ser Pro  Gly Glu Arg Pro Ser  Gly Met Phe Asp Ser  Val Val Leu 
    1505                 1510                 1515             


Cys Glu  Cys Tyr Asp Ala Gly  Cys Ala Trp Tyr Glu  Leu Thr Pro 
    1520                 1525                 1530             


Ala Glu  Thr Thr Val Arg Leu  Arg Ala Tyr Leu Asn  Thr Pro Gly 
    1535                 1540                 1545             


Leu Pro  Val Cys Gln Asp His  Leu Glu Phe Trp Glu  Gly Val Phe 
    1550                 1555                 1560             


Thr Gly  Leu Thr His Ile Asp  Ala His Phe Leu Ser  Gln Thr Lys 
    1565                 1570                 1575             


Gln Ser  Gly Glu Asn Phe Pro  Tyr Leu Val Ala Tyr  Gln Ala Thr 
    1580                 1585                 1590             


Val Cys  Ala Arg Ala Xaa Ala  Pro Pro Pro Ser Trp  Asp Xaa Met 
    1595                 1600                 1605             


Trp Lys  Cys Leu Ile Arg Leu  Lys Pro Thr Leu His  Gly Pro Thr 
    1610                 1615                 1620             


Pro Leu  Leu Tyr Arg Leu Gly  Ala Val Gln Asn Glu  Val Thr Leu 
    1625                 1630                 1635             


Thr His  Pro Ile Thr Lys Tyr  Ile Met Thr Cys Met  Ser Ala Asp 
    1640                 1645                 1650             


Leu Glu  Val Val Thr Ser Thr  Trp Val Leu Val Gly  Gly Val Leu 
    1655                 1660                 1665             


Ala Ala  Leu Ala Ala Tyr Cys  Leu Ser Thr Gly Cys  Val Val Ile 
    1670                 1675                 1680             


Val Gly  Arg Ile Val Leu Ser  Gly Lys Pro Ala Xaa  Ile Pro Asp 
    1685                 1690                 1695             


Arg Glu  Val Leu Tyr Gln Gln  Phe Asp Glu Met Glu  Glu Cys Ser 
    1700                 1705                 1710             


Gln His  Leu Pro Tyr Ile Glu  Gln Gly Gln Gln Ile  Ala Glu Gln 
    1715                 1720                 1725             


Phe Lys  Gln Lys Ala Leu Gly  Leu Leu Gln Thr Ala  Thr Lys Gln 
    1730                 1735                 1740             


Ala Glu  Val Ile Ala Pro Ala  Val Gln Xaa Asn Trp  Gln Lys Leu 
    1745                 1750                 1755             


Glu Gln  Phe Trp Ala Lys His  Met Trp Asn Phe Ile  Ser Gly Ile 
    1760                 1765                 1770             


Gln Tyr  Leu Ala Gly Leu Ser  Thr Leu Pro Gly Asn  Pro Ala Val 
    1775                 1780                 1785             


Ala Ser  Leu Met Ala Phe Thr  Ala Ala Val Thr Ser  Pro Leu Thr 
    1790                 1795                 1800             


Thr Ser  Gln Thr Leu Leu Phe  Asn Ile Leu Gly Gly  Trp Val Ala 
    1805                 1810                 1815             


Ser Gln  Leu Ala Pro Pro Thr  Ala Ala Thr Ala Phe  Val Val Ser 
    1820                 1825                 1830             


Gly Leu  Ala Gly Ala Ala Val  Gly Ser Ile Gly Leu  Gly Lys Val 
    1835                 1840                 1845             


Leu Val  Asp Ile Leu Ala Gly  Tyr Gly Ala Gly Val  Ala Gly Ala 
    1850                 1855                 1860             


Leu Val  Ala Phe Lys Ile Met  Ser Gly Glu Xaa Pro  Ser Thr Glu 
    1865                 1870                 1875             


Asp Leu  Val Asn Leu Leu Pro  Ala Ile Leu Ser Pro  Gly Ala Leu 
    1880                 1885                 1890             


Val Val  Gly Val Val Cys Ala  Ala Ile Leu Arg Arg  His Val Gly 
    1895                 1900                 1905             


Pro Gly  Glu Gly Ala Val Gln  Trp Met Asn Arg Leu  Ile Ala Phe 
    1910                 1915                 1920             


Ala Ser  Arg Gly Asn His Val  Ser Pro Thr His Tyr  Val Pro Glu 
    1925                 1930                 1935             


Ser Asp  Ala Ala Ala Arg Val  Thr Gln Ile Leu Ser  Ser Leu Thr 
    1940                 1945                 1950             


Val Thr  Ser Leu Leu Arg Arg  Leu His Gln Trp Ile  Asn Glu Asp 
    1955                 1960                 1965             


Cys Ser  Thr Pro Cys Ser Gly  Ser Trp Leu Arg Asp  Ile Trp Asp 
    1970                 1975                 1980             


Trp Val  Cys Thr Val Leu Ser  Asp Phe Lys Thr Trp  Leu Lys Ala 
    1985                 1990                 1995             


Lys Leu  Leu Pro Gln Leu Pro  Gly Ile Pro Phe Leu  Ser Cys Gln 
    2000                 2005                 2010             


Arg Gly  Tyr Lys Gly Val Trp  Arg Gly Asp Gly Val  Met His Thr 
    2015                 2020                 2025             


Arg Cys  Pro Cys Gly Ala Glu  Ile Thr Gly His Val  Lys Asn Gly 
    2030                 2035                 2040             


Ser Met  Arg Ile Val Gly Pro  Lys Thr Cys Ser Asn  Thr Trp His 
    2045                 2050                 2055             


Gly Thr  Phe Pro Ile Asn Ala  Tyr Thr Thr Gly Pro  Xaa Xaa Pro 
    2060                 2065                 2070             


Xaa Pro  Ala Pro Asn Tyr Lys  Arg Ala Leu Trp Arg  Val Xaa Ala 
    2075                 2080                 2085             


Glu Glu  Tyr Val Glu Val Arg  Arg Val Gly Asp Phe  His Tyr Val 
    2090                 2095                 2100             


Thr Gly  Xaa Thr Thr Asp Asn  Leu Lys Cys Pro Cys  Gln Val Pro 
    2105                 2110                 2115             


Ala Pro  Glu Phe Phe Thr Glu  Val Asp Gly Val Arg  Leu His Arg 
    2120                 2125                 2130             


Xaa Ala  Pro Pro Cys Lys Pro  Leu Leu Arg Asp Glu  Val Thr Phe 
    2135                 2140                 2145             


Ser Val  Gly Leu Asn Ser Tyr  Val Val Gly Ser Gln  Leu Pro Cys 
    2150                 2155                 2160             


Glu Pro  Glu Pro Asp Val Ala  Val Leu Thr Ser Met  Leu Thr Asp 
    2165                 2170                 2175             


Pro Ser  His Ile Thr Ala Glu  Thr Ala Ala Arg Arg  Leu Ala Arg 
    2180                 2185                 2190             


Gly Ser  Pro Pro Ser Leu Ala  Ser Ser Ser Ala Ser  Gln Leu Ser 
    2195                 2200                 2205             


Ala Pro  Ser Leu Lys Ala Thr  Cys Thr Thr His His  Asp His Pro 
    2210                 2215                 2220             


Asp Ala  Glu Leu Ile Glu Ala  Asn Leu Leu Trp Arg  Gln Glu Met 
    2225                 2230                 2235             


Gly Gly  Asn Ile Thr Arg Val  Glu Ser Glu Asn Lys  Val Val Ile 
    2240                 2245                 2250             


Leu Asp  Ser Phe Asp Pro Leu  Val Ala Glu Glu Asp  Asp Arg Glu 
    2255                 2260                 2265             


Ile Ser  Val Pro Ala Glu Cys  Leu Arg Lys Xaa Arg  Lys Phe Pro 
    2270                 2275                 2280             


Pro Ala  Leu Pro Ile Trp Ala  Arg Pro Asp Tyr Asn  Pro Pro Leu 
    2285                 2290                 2295             


Leu Glu  Thr Trp Lys Arg Pro  Asp Tyr Glu Pro Pro  Thr Val His 
    2300                 2305                 2310             


Gly Cys  Ala Leu Pro Pro Pro  Xaa Ala Pro Pro Val  Pro Pro Pro 
    2315                 2320                 2325             


Arg Arg  Lys Arg Thr Val Xaa  Leu Thr Glu Ser Thr  Val Ser Thr 
    2330                 2335                 2340             


Ala Leu  Ala Glu Leu Ala Glu  Lys Ser Phe Gly Ser  Ser Glu Xaa 
    2345                 2350                 2355             


Ser Gly  Xaa Xaa Ser Xaa Ser  Gly Xaa Asp Thr Thr  Ser Ser Xaa 
    2360                 2365                 2370             


Xaa Ser  Xaa Pro Pro Asp Cys  Asp Ala Xaa Ser Asp  Ala Glu Ser 
    2375                 2380                 2385             


Tyr Ser  Ser Met Pro Pro Leu  Glu Gly Glu Pro Gly  Asp Pro Asp 
    2390                 2395                 2400             


Leu Ser  Asp Gly Ser Trp Ser  Thr Val Ser Asp Glu  Glu Asp Ser 
    2405                 2410                 2415             


Val Val  Cys Cys Ser Met Ser  Tyr Ser Trp Thr Gly  Ala Leu Ile 
    2420                 2425                 2430             


Thr Pro  Cys Ala Ala Glu Glu  Glu Lys Leu Pro Ile  Asn Pro Leu 
    2435                 2440                 2445             


Ser Asn  Ser Leu Leu Arg His  His Asn Leu Val Tyr  Ser Thr Thr 
    2450                 2455                 2460             


Ser Arg  Ser Ala Ser Gln Arg  Gln Lys Lys Val Thr  Phe Asp Arg 
    2465                 2470                 2475             


Leu Gln  Val Leu Asp Asp His  Tyr Xaa Asp Val Leu  Lys Glu Val 
    2480                 2485                 2490             


Lys Ala  Xaa Ala Ser Lys Val  Lys Ala Arg Leu Leu  Ser Val Glu 
    2495                 2500                 2505             


Glu Ala  Cys Ala Leu Thr Pro  Pro His Ser Ala Arg  Ser Lys Phe 
    2510                 2515                 2520             


Gly Tyr  Gly Ala Lys Asp Val  Arg Ser Leu Ser Arg  Lys Ala Val 
    2525                 2530                 2535             


Asn His  Ile Xaa Ser Val Trp  Xaa Asp Leu Leu Glu  Asp Ser Thr 
    2540                 2545                 2550             


Thr Pro  Ile Pro Thr Thr Ile  Met Ala Lys Asn Glu  Val Phe Cys 
    2555                 2560                 2565             


Val Asp  Pro Xaa Lys Gly Gly  Arg Lys Pro Ala Arg  Leu Ile Val 
    2570                 2575                 2580             


Tyr Pro  Asp Leu Gly Val Arg  Val Cys Glu Lys Arg  Ala Leu Tyr 
    2585                 2590                 2595             


Asp Val  Xaa Gln Lys Leu Pro  Lys Ala Val Met Gly  Ser Ser Tyr 
    2600                 2605                 2610             


Gly Phe  Gln Tyr Ser Pro Ala  Gln Arg Val Glu Phe  Leu Leu Lys 
    2615                 2620                 2625             


Ala Trp  Lys Ser Lys Lys Thr  Pro Met Gly Phe Ser  Tyr Asp Thr 
    2630                 2635                 2640             


Arg Cys  Phe Asp Ser Thr Val  Thr Glu Xaa Asp Ile  Arg Thr Glu 
    2645                 2650                 2655             


Glu Xaa  Ile Tyr Gln Cys Cys  Asp Leu Asp Pro Glu  Ala Arg Lys 
    2660                 2665                 2670             


Ala Ile  Xaa Ser Leu Thr Glu  Arg Leu Tyr Val Gly  Gly Pro Met 
    2675                 2680                 2685             


Xaa Asn  Ser Lys Gly Gln Xaa  Cys Gly Tyr Arg Arg  Cys Arg Ala 
    2690                 2695                 2700             


Ser Gly  Val Leu Thr Thr Ser  Met Gly Asn Thr Leu  Thr Cys Tyr 
    2705                 2710                 2715             


Ile Lys  Ala Xaa Ala Ala Cys  Arg Ala Ala Gly Leu  Arg Asp Cys 
    2720                 2725                 2730             


Thr Met  Leu Val Cys Gly Asp  Asp Leu Val Val Ile  Cys Glu Ser 
    2735                 2740                 2745             


Ala Gly  Val Glx Glu Asp Ala  Ala Xaa Leu Arg Ala  Phe Thr Glu 
    2750                 2755                 2760             


Ala Met  Thr Arg Tyr Ser Ala  Pro Pro Gly Asp Pro  Pro Gln Pro 
    2765                 2770                 2775             


Glu Tyr  Asp Leu Glu Leu Ile  Thr Ser Cys Ser Ser  Asn Val Ser 
    2780                 2785                 2790             


Val Ala  His Asp Xaa Ser Gly  Lys Arg Val Tyr Tyr  Leu Thr Arg 
    2795                 2800                 2805             


Asp Pro  Thr Thr Pro Leu Ala  Arg Ala Ala Trp Glu  Thr Ala Arg 
    2810                 2815                 2820             


His Thr  Pro Val Asn Ser Trp  Leu Gly Asn Ile Ile  Met Tyr Ala 
    2825                 2830                 2835             


Pro Thr  Ile Trp Val Arg Met  Val Leu Met Thr His  Phe Phe Ser 
    2840                 2845                 2850             


Ile Leu  Gln Xaa Gln Glu Gln  Leu Glu Xaa Ala Leu  Asp Phe Glu 
    2855                 2860                 2865             


Met Tyr  Gly Ala Thr Tyr Ser  Val Thr Pro Leu Asp  Leu Pro Ala 
    2870                 2875                 2880             


Ile Ile  Gln Arg Leu His Gly  Leu Ser Ala Phe Ser  Leu His Ser 
    2885                 2890                 2895             


Tyr Ser  Pro Gly Glu Leu Asn  Arg Val Ala Ala Cys  Leu Arg Lys 
    2900                 2905                 2910             


Leu Gly  Val Pro Pro Leu Arg  Ala Trp Arg His Arg  Ala Arg Ala 
    2915                 2920                 2925             


Val Arg  Ala Lys Leu Ile Ala  Gln Gly Gly Arg Ala  Ala Ile Cys 
    2930                 2935                 2940             


Gly Lys  Tyr Leu Phe Asn Trp  Ala Val Arg Thr Lys  Leu Lys Leu 
    2945                 2950                 2955             


Thr Pro  Leu Pro Ala Ala Gly  Xaa Leu Asp Leu Ser  Ser Trp Phe 
    2960                 2965                 2970             


Thr Val  Gly Ala Gly Gly Gly  Asp Ile Tyr His Ser  Val Ser Arg 
    2975                 2980                 2985             


Ala Arg  Pro Arg Trp Leu Leu  Leu Cys Leu Leu Leu  Leu Xaa Val 
    2990                 2995                 3000             


Gly Val  Gly Ile Phe Leu Leu  Pro Ala Arg Xaa 
    3005                 3010                 


<210>  97
<211>  3012
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic Sequence


<220>
<221>  misc_feature
<222>  (3012)..(3012)
<223>  Xaa can be any amino acid

<400>  97

Met Ser Thr Asn Pro Lys Pro Gln Arg Lys Thr Lys Arg Asn Thr Asn 
1               5                   10                  15      


Arg Arg Pro Gln Asp Val Lys Phe Pro Gly Gly Gly Gln Ile Val Gly 
            20                  25                  30          


Gly Val Tyr Leu Leu Pro Arg Arg Gly Pro Arg Leu Gly Val Arg Ala 
        35                  40                  45              


Thr Arg Lys Thr Ser Glu Arg Ser Gln Pro Arg Gly Arg Arg Gln Pro 
    50                  55                  60                  


Ile Pro Lys Ala Arg Arg Pro Glu Gly Arg Thr Trp Ala Gln Pro Gly 
65                  70                  75                  80  


Tyr Pro Trp Pro Leu Tyr Gly Asn Glu Gly Cys Gly Trp Ala Gly Trp 
                85                  90                  95      


Leu Leu Ser Pro Arg Gly Ser Arg Pro Ser Trp Gly Pro Thr Asp Pro 
            100                 105                 110         


Arg Arg Arg Ser Arg Asn Leu Gly Lys Val Ile Asp Thr Leu Thr Cys 
        115                 120                 125             


Gly Phe Ala Asp Leu Met Gly Tyr Ile Pro Leu Val Gly Ala Pro Leu 
    130                 135                 140                 


Gly Gly Ala Ala Arg Ala Leu Ala His Gly Val Arg Val Leu Glu Asp 
145                 150                 155                 160 


Gly Val Asn Tyr Ala Thr Gly Asn Leu Pro Gly Cys Ser Phe Ser Ile 
                165                 170                 175     


Phe Leu Leu Ala Leu Leu Ser Cys Leu Thr Val Pro Ala Ser Ala Tyr 
            180                 185                 190         


Gln Val Arg Asn Ser Thr Gly Leu Tyr His Val Thr Asn Asp Cys Pro 
        195                 200                 205             


Asn Ser Ser Ile Val Tyr Glu Ala Ala Asp Ala Ile Leu His Thr Pro 
    210                 215                 220                 


Gly Cys Val Pro Cys Val Arg Glu Gly Asn Ala Ser Arg Cys Trp Val 
225                 230                 235                 240 


Ala Val Thr Pro Thr Val Ala Thr Arg Asp Gly Lys Leu Pro Thr Thr 
                245                 250                 255     


Gln Leu Arg Arg His Ile Asp Leu Leu Val Gly Ser Ala Thr Leu Cys 
            260                 265                 270         


Ser Ala Leu Tyr Val Gly Asp Leu Cys Gly Ser Val Phe Leu Val Gly 
        275                 280                 285             


Gln Leu Phe Thr Phe Ser Pro Arg Arg His Trp Thr Thr Gln Asp Cys 
    290                 295                 300                 


Asn Cys Ser Ile Tyr Pro Gly His Ile Thr Gly His Arg Met Ala Trp 
305                 310                 315                 320 


Asp Met Met Met Asn Trp Ser Pro Thr Thr Ala Leu Val Val Ala Gln 
                325                 330                 335     


Leu Leu Arg Ile Pro Gln Ala Ile Leu Asp Met Ile Ala Gly Ala His 
            340                 345                 350         


Trp Gly Val Leu Ala Gly Ile Ala Tyr Phe Ser Met Val Gly Asn Trp 
        355                 360                 365             


Ala Lys Val Leu Val Val Leu Leu Leu Phe Ala Gly Val Asp Ala Glu 
    370                 375                 380                 


Thr His Val Thr Gly Gly Ser Ala Ala Arg Thr Thr Ser Gly Leu Ala 
385                 390                 395                 400 


Ser Leu Phe Thr Pro Gly Ala Lys Gln Asn Ile Gln Leu Ile Asn Thr 
                405                 410                 415     


Asn Gly Ser Trp His Ile Asn Arg Thr Ala Leu Asn Cys Asn Asp Ser 
            420                 425                 430         


Leu Asn Thr Gly Trp Leu Ala Gly Leu Phe Tyr Tyr His Lys Phe Asn 
        435                 440                 445             


Ser Ser Gly Cys Pro Glu Arg Leu Ala Ser Cys Arg Pro Leu Thr Asp 
    450                 455                 460                 


Phe Asp Gln Gly Trp Gly Pro Ile Ser Tyr Ala Asn Gly Ser Gly Pro 
465                 470                 475                 480 


Asp Gln Arg Pro Tyr Cys Trp His Tyr Pro Pro Lys Pro Cys Gly Ile 
                485                 490                 495     


Val Pro Ala Lys Ser Val Cys Gly Pro Val Tyr Cys Phe Thr Pro Ser 
            500                 505                 510         


Pro Val Val Val Gly Thr Thr Asp Arg Ser Gly Ala Pro Thr Tyr Asn 
        515                 520                 525             


Trp Gly Glu Asn Asp Thr Asp Val Phe Val Leu Asn Asn Thr Arg Pro 
    530                 535                 540                 


Pro Leu Gly Asn Trp Phe Gly Cys Thr Trp Met Asn Ser Thr Gly Phe 
545                 550                 555                 560 


Thr Lys Val Cys Gly Ala Pro Pro Cys Val Ile Gly Gly Val Gly Asn 
                565                 570                 575     


Asn Thr Leu His Cys Pro Thr Asp Cys Phe Arg Lys His Pro Glu Ala 
            580                 585                 590         


Thr Tyr Ser Arg Cys Gly Ser Gly Pro Trp Ile Thr Pro Arg Cys Leu 
        595                 600                 605             


Val Asp Tyr Pro Tyr Arg Leu Trp His Tyr Pro Cys Thr Ile Asn Tyr 
    610                 615                 620                 


Thr Ile Phe Lys Val Arg Met Tyr Val Gly Gly Val Glu His Arg Leu 
625                 630                 635                 640 


Glu Ala Ala Cys Asn Trp Thr Arg Gly Glu Arg Cys Asp Leu Glu Asp 
                645                 650                 655     


Arg Asp Arg Ser Glu Leu Ser Pro Leu Leu Leu Ser Thr Thr Gln Trp 
            660                 665                 670         


Gln Val Leu Pro Cys Ser Phe Thr Thr Leu Pro Ala Leu Ser Thr Gly 
        675                 680                 685             


Leu Ile His Leu His Gln Asn Ile Val Asp Val Gln Tyr Leu Tyr Gly 
    690                 695                 700                 


Val Gly Ser Ser Ile Ala Ser Trp Ala Ile Lys Trp Glu Tyr Val Val 
705                 710                 715                 720 


Leu Leu Phe Leu Leu Leu Ala Asp Ala Arg Val Cys Ser Cys Leu Trp 
                725                 730                 735     


Met Met Leu Leu Ile Ser Gln Ala Glu Ala Ala Leu Glu Asn Leu Val 
            740                 745                 750         


Val Leu Asn Ala Ala Ser Leu Ala Gly Thr His Gly Leu Val Ser Phe 
        755                 760                 765             


Leu Val Phe Phe Cys Phe Ala Trp Tyr Leu Lys Gly Arg Trp Val Pro 
    770                 775                 780                 


Gly Ala Ala Tyr Ala Leu Tyr Gly Met Trp Pro Leu Leu Leu Leu Leu 
785                 790                 795                 800 


Leu Ala Leu Pro Gln Arg Ala Tyr Ala Leu Asp Thr Glu Val Ala Ala 
                805                 810                 815     


Ser Cys Gly Gly Val Val Leu Val Gly Leu Met Ala Leu Thr Leu Ser 
            820                 825                 830         


Pro Tyr Tyr Lys Arg Tyr Ile Ser Trp Cys Leu Trp Trp Leu Gln Tyr 
        835                 840                 845             


Phe Leu Thr Arg Val Glu Ala Gln Leu His Val Trp Val Pro Pro Leu 
    850                 855                 860                 


Asn Val Arg Gly Gly Arg Asp Ala Val Ile Leu Leu Met Cys Val Val 
865                 870                 875                 880 


His Pro Thr Leu Val Phe Asp Ile Thr Lys Leu Leu Leu Ala Val Phe 
                885                 890                 895     


Gly Pro Leu Trp Ile Leu Gln Ala Ser Leu Leu Lys Val Pro Tyr Phe 
            900                 905                 910         


Val Arg Val Gln Gly Leu Leu Arg Ile Cys Ala Leu Ala Arg Lys Met 
        915                 920                 925             


Ala Gly Gly His Tyr Val Gln Met Ala Ile Ile Lys Leu Gly Ala Leu 
    930                 935                 940                 


Thr Gly Thr Tyr Val Tyr Asn His Leu Thr Pro Leu Arg Asp Trp Ala 
945                 950                 955                 960 


His Asn Gly Leu Arg Asp Leu Ala Val Ala Val Glu Pro Val Val Phe 
                965                 970                 975     


Ser Gln Met Glu Thr Lys Leu Ile Thr Trp Gly Ala Asp Thr Ala Ala 
            980                 985                 990         


Cys Gly Asp Ile Ile Asn Gly Leu  Pro Val Ser Ala Arg  Arg Gly Arg 
        995                 1000                 1005             


Glu Ile  Leu Leu Gly Pro Ala  Asp Gly Met Val Ser  Lys Gly Trp 
    1010                 1015                 1020             


Arg Leu  Leu Ala Pro Ile Thr  Ala Tyr Ala Gln Gln  Thr Arg Gly 
    1025                 1030                 1035             


Leu Leu  Gly Cys Ile Ile Thr  Ser Leu Thr Gly Arg  Asp Lys Asn 
    1040                 1045                 1050             


Gln Val  Glu Gly Glu Val Gln  Ile Val Ser Thr Ala  Ala Gln Thr 
    1055                 1060                 1065             


Phe Leu  Ala Thr Cys Ile Asn  Gly Val Cys Trp Thr  Val Tyr His 
    1070                 1075                 1080             


Gly Ala  Gly Thr Arg Thr Ile  Ala Ser Pro Lys Gly  Pro Val Ile 
    1085                 1090                 1095             


Gln Met  Tyr Thr Asn Val Asp  Gln Asp Leu Val Gly  Trp Pro Ala 
    1100                 1105                 1110             


Pro Gln  Gly Ala Arg Ser Leu  Thr Pro Cys Thr Cys  Gly Ser Ser 
    1115                 1120                 1125             


Asp Leu  Tyr Leu Val Thr Arg  His Ala Asp Val Ile  Pro Val Arg 
    1130                 1135                 1140             


Arg Arg  Gly Asp Ser Arg Gly  Ser Leu Leu Ser Pro  Arg Pro Ile 
    1145                 1150                 1155             


Ser Tyr  Leu Lys Gly Ser Ser  Gly Gly Pro Leu Leu  Cys Pro Ala 
    1160                 1165                 1170             


Gly His  Ala Val Gly Ile Phe  Arg Ala Ala Val Cys  Thr Arg Gly 
    1175                 1180                 1185             


Val Ala  Lys Ala Val Asp Phe  Ile Pro Val Glu Asn  Leu Glu Thr 
    1190                 1195                 1200             


Thr Met  Arg Ser Pro Val Phe  Thr Asp Asn Ser Ser  Pro Pro Ala 
    1205                 1210                 1215             


Val Pro  Gln Ser Phe Gln Val  Ala His Leu His Ala  Pro Thr Gly 
    1220                 1225                 1230             


Ser Gly  Lys Ser Thr Lys Val  Pro Ala Ala Tyr Ala  Ala Gln Gly 
    1235                 1240                 1245             


Tyr Lys  Val Leu Val Leu Asn  Pro Ser Val Ala Ala  Thr Leu Gly 
    1250                 1255                 1260             


Phe Gly  Ala Tyr Met Ser Lys  Ala His Gly Ile Asp  Pro Asn Ile 
    1265                 1270                 1275             


Arg Thr  Gly Val Arg Thr Ile  Thr Thr Gly Ser Pro  Ile Thr Tyr 
    1280                 1285                 1290             


Ser Thr  Tyr Gly Lys Phe Leu  Ala Asp Gly Gly Cys  Ser Gly Gly 
    1295                 1300                 1305             


Ala Tyr  Asp Ile Ile Ile Cys  Asp Glu Cys His Ser  Thr Asp Ala 
    1310                 1315                 1320             


Thr Ser  Ile Leu Gly Ile Gly  Thr Val Leu Asp Gln  Ala Glu Thr 
    1325                 1330                 1335             


Ala Gly  Ala Arg Leu Val Val  Leu Ala Thr Ala Thr  Pro Pro Gly 
    1340                 1345                 1350             


Ser Val  Thr Val Pro His Pro  Asn Ile Glu Glu Val  Ala Leu Ser 
    1355                 1360                 1365             


Thr Thr  Gly Glu Ile Pro Phe  Tyr Gly Lys Ala Ile  Pro Leu Glu 
    1370                 1375                 1380             


Val Ile  Lys Gly Gly Arg His  Leu Ile Phe Cys His  Ser Lys Lys 
    1385                 1390                 1395             


Lys Cys  Asp Glu Leu Ala Ala  Lys Leu Val Ala Leu  Gly Ile Asn 
    1400                 1405                 1410             


Ala Val  Ala Tyr Tyr Arg Gly  Leu Asp Val Ser Val  Ile Pro Thr 
    1415                 1420                 1425             


Ser Gly  Asp Val Val Val Val  Ala Thr Asp Ala Leu  Met Thr Gly 
    1430                 1435                 1440             


Phe Thr  Gly Asp Phe Asp Ser  Val Ile Asp Cys Asn  Thr Cys Val 
    1445                 1450                 1455             


Thr Gln  Thr Val Asp Phe Ser  Leu Asp Pro Thr Phe  Thr Ile Glu 
    1460                 1465                 1470             


Thr Thr  Thr Leu Pro Gln Asp  Ala Val Ser Arg Thr  Gln Arg Arg 
    1475                 1480                 1485             


Gly Arg  Thr Gly Arg Gly Lys  Pro Gly Ile Tyr Arg  Phe Val Ala 
    1490                 1495                 1500             


Pro Gly  Glu Arg Pro Ser Gly  Met Phe Asp Ser Ser  Val Leu Cys 
    1505                 1510                 1515             


Glu Cys  Tyr Asp Ala Gly Cys  Ala Trp Tyr Glu Leu  Thr Pro Ala 
    1520                 1525                 1530             


Glu Thr  Thr Val Arg Leu Arg  Ala Tyr Met Asn Thr  Pro Gly Leu 
    1535                 1540                 1545             


Pro Val  Cys Gln Asp His Leu  Glu Phe Trp Glu Gly  Val Phe Thr 
    1550                 1555                 1560             


Gly Leu  Thr His Ile Asp Ala  His Phe Leu Ser Gln  Thr Lys Gln 
    1565                 1570                 1575             


Ser Gly  Glu Asn Leu Pro Tyr  Leu Val Ala Tyr Gln  Ala Thr Val 
    1580                 1585                 1590             


Cys Ala  Arg Ala Gln Ala Pro  Pro Pro Ser Trp Asp  Gln Met Trp 
    1595                 1600                 1605             


Lys Cys  Leu Ile Arg Leu Lys  Pro Thr Leu His Gly  Pro Thr Pro 
    1610                 1615                 1620             


Leu Leu  Tyr Arg Leu Gly Ala  Val Gln Asn Glu Val  Thr Leu Thr 
    1625                 1630                 1635             


His Pro  Ile Thr Lys Tyr Ile  Met Thr Cys Met Ser  Ala Asp Leu 
    1640                 1645                 1650             


Glu Val  Val Thr Ser Thr Trp  Val Leu Val Gly Gly  Val Leu Ala 
    1655                 1660                 1665             


Ala Leu  Ala Ala Tyr Cys Leu  Ser Thr Gly Cys Val  Val Ile Val 
    1670                 1675                 1680             


Gly Arg  Ile Val Leu Ser Gly  Lys Pro Ala Ile Ile  Pro Asp Arg 
    1685                 1690                 1695             


Glu Val  Leu Tyr Arg Glu Phe  Asp Glu Met Glu Glu  Cys Ser Gln 
    1700                 1705                 1710             


His Leu  Pro Tyr Ile Glu Gln  Gly Met Met Leu Ala  Glu Gln Phe 
    1715                 1720                 1725             


Lys Gln  Lys Ala Leu Gly Leu  Leu Gln Thr Ala Ser  Arg Gln Ala 
    1730                 1735                 1740             


Glu Val  Ile Ala Pro Ala Val  Gln Thr Asn Trp Gln  Lys Leu Glu 
    1745                 1750                 1755             


Ala Phe  Trp Ala Lys His Met  Trp Asn Phe Ile Ser  Gly Ile Gln 
    1760                 1765                 1770             


Tyr Leu  Ala Gly Leu Ser Thr  Leu Pro Gly Asn Pro  Ala Ile Ala 
    1775                 1780                 1785             


Ser Leu  Met Ala Phe Thr Ala  Ala Val Thr Ser Pro  Leu Thr Thr 
    1790                 1795                 1800             


Ser Gln  Thr Leu Leu Phe Asn  Ile Leu Gly Gly Trp  Val Ala Ala 
    1805                 1810                 1815             


Gln Leu  Ala Ala Pro Gly Ala  Ala Thr Ala Phe Val  Gly Ala Gly 
    1820                 1825                 1830             


Leu Ala  Gly Ala Ala Ile Gly  Ser Val Gly Leu Gly  Lys Val Leu 
    1835                 1840                 1845             


Val Asp  Ile Leu Ala Gly Tyr  Gly Ala Gly Val Ala  Gly Ala Leu 
    1850                 1855                 1860             


Val Ala  Phe Lys Ile Met Ser  Gly Glu Val Pro Ser  Thr Glu Asp 
    1865                 1870                 1875             


Leu Val  Asn Leu Leu Pro Ala  Ile Leu Ser Pro Gly  Ala Leu Val 
    1880                 1885                 1890             


Val Gly  Val Val Cys Ala Ala  Ile Leu Arg Arg His  Val Gly Pro 
    1895                 1900                 1905             


Gly Glu  Gly Ala Val Gln Trp  Met Asn Arg Leu Ile  Ala Phe Ala 
    1910                 1915                 1920             


Ser Arg  Gly Asn His Val Ser  Pro Thr His Tyr Val  Pro Glu Ser 
    1925                 1930                 1935             


Asp Ala  Ala Ala Arg Val Thr  Ala Ile Leu Ser Ser  Leu Thr Val 
    1940                 1945                 1950             


Thr Gln  Leu Leu Arg Arg Leu  His Gln Trp Ile Ser  Ser Glu Cys 
    1955                 1960                 1965             


Thr Thr  Pro Cys Ser Gly Ser  Trp Leu Arg Asp Ile  Trp Asp Trp 
    1970                 1975                 1980             


Ile Cys  Glu Val Leu Ser Asp  Phe Lys Thr Trp Leu  Lys Ala Lys 
    1985                 1990                 1995             


Leu Met  Pro Gln Leu Pro Gly  Ile Pro Phe Val Ser  Cys Gln Arg 
    2000                 2005                 2010             


Gly Tyr  Arg Gly Val Trp Arg  Gly Asp Gly Ile Met  His Thr Arg 
    2015                 2020                 2025             


Cys His  Cys Gly Ala Glu Ile  Thr Gly His Val Lys  Asn Gly Thr 
    2030                 2035                 2040             


Met Arg  Ile Val Gly Pro Arg  Thr Cys Arg Asn Met  Trp Ser Gly 
    2045                 2050                 2055             


Thr Phe  Pro Ile Asn Ala Tyr  Thr Thr Gly Pro Cys  Thr Pro Leu 
    2060                 2065                 2070             


Pro Ala  Pro Asn Tyr Thr Phe  Ala Leu Trp Arg Val  Ser Ala Glu 
    2075                 2080                 2085             


Glu Tyr  Val Glu Ile Arg Gln  Val Gly Asp Phe His  Tyr Val Thr 
    2090                 2095                 2100             


Gly Met  Thr Thr Asp Asn Leu  Lys Cys Pro Cys Gln  Val Pro Ser 
    2105                 2110                 2115             


Pro Glu  Phe Phe Thr Glu Leu  Asp Gly Val Arg Leu  His Arg Phe 
    2120                 2125                 2130             


Ala Pro  Pro Cys Lys Pro Leu  Leu Arg Glu Glu Val  Ser Phe Arg 
    2135                 2140                 2145             


Val Gly  Leu His Glu Tyr Pro  Val Gly Ser Gln Leu  Pro Cys Glu 
    2150                 2155                 2160             


Pro Glu  Pro Asp Val Ala Val  Leu Thr Ser Met Leu  Thr Asp Pro 
    2165                 2170                 2175             


Ser His  Ile Thr Ala Glu Ala  Ala Gly Arg Arg Leu  Ala Arg Gly 
    2180                 2185                 2190             


Ser Pro  Pro Ser Val Ala Ser  Ser Ser Ala Ser Gln  Leu Ser Ala 
    2195                 2200                 2205             


Pro Ser  Leu Lys Ala Thr Cys  Thr Ala Asn His Asp  Ser Pro Asp 
    2210                 2215                 2220             


Ala Glu  Leu Ile Glu Ala Asn  Leu Leu Trp Arg Gln  Glu Met Gly 
    2225                 2230                 2235             


Gly Asn  Ile Thr Arg Val Glu  Ser Glu Asn Lys Val  Val Ile Leu 
    2240                 2245                 2250             


Asp Ser  Phe Asp Pro Leu Val  Ala Glu Glu Asp Glu  Arg Glu Ile 
    2255                 2260                 2265             


Ser Val  Pro Ala Glu Ile Leu  Arg Lys Ser Arg Arg  Phe Ala Pro 
    2270                 2275                 2280             


Ala Leu  Pro Ile Trp Ala Arg  Pro Asp Tyr Asn Pro  Pro Leu Leu 
    2285                 2290                 2295             


Glu Thr  Trp Lys Lys Pro Asp  Tyr Glu Pro Pro Val  Val His Gly 
    2300                 2305                 2310             


Cys Pro  Leu Pro Pro Pro Gln  Ser Pro Pro Val Pro  Pro Pro Arg 
    2315                 2320                 2325             


Lys Lys  Arg Thr Val Val Leu  Thr Glu Ser Thr Val  Ser Thr Ala 
    2330                 2335                 2340             


Leu Ala  Glu Leu Ala Thr Lys  Ser Phe Gly Ser Ser  Ser Thr Ser 
    2345                 2350                 2355             


Gly Ile  Thr Gly Asp Asn Thr  Thr Thr Ser Ser Glu  Pro Ala Pro 
    2360                 2365                 2370             


Ser Gly  Cys Pro Pro Asp Ser  Asp Ala Glu Ser Tyr  Ser Ser Met 
    2375                 2380                 2385             


Pro Pro  Leu Glu Gly Glu Pro  Gly Asp Pro Asp Leu  Ser Asp Gly 
    2390                 2395                 2400             


Ser Trp  Ser Thr Val Ser Ser  Glu Ala Asp Thr Glu  Asp Val Val 
    2405                 2410                 2415             


Cys Cys  Ser Met Ser Tyr Ser  Trp Thr Gly Ala Leu  Val Thr Pro 
    2420                 2425                 2430             


Cys Ala  Ala Glu Glu Gln Lys  Leu Pro Ile Asn Ala  Leu Ser Asn 
    2435                 2440                 2445             


Ser Leu  Leu Arg His His Asn  Leu Val Tyr Ser Thr  Thr Ser Arg 
    2450                 2455                 2460             


Ser Ala  Cys Gln Arg Gln Lys  Lys Val Thr Phe Asp  Arg Leu Gln 
    2465                 2470                 2475             


Val Leu  Asp Ser His Tyr Gln  Asp Val Leu Lys Glu  Val Lys Ala 
    2480                 2485                 2490             


Ala Ala  Ser Lys Val Lys Ala  Asn Leu Leu Ser Val  Glu Glu Ala 
    2495                 2500                 2505             


Cys Ser  Leu Thr Pro Pro His  Ser Ala Lys Ser Lys  Phe Gly Tyr 
    2510                 2515                 2520             


Gly Ala  Lys Asp Val Arg Cys  His Ala Arg Lys Ala  Val Asn His 
    2525                 2530                 2535             


Ile Asn  Ser Val Trp Lys Asp  Leu Leu Glu Asp Ser  Val Thr Pro 
    2540                 2545                 2550             


Ile Asp  Thr Thr Ile Met Ala  Lys Asn Glu Val Phe  Cys Val Gln 
    2555                 2560                 2565             


Pro Glu  Lys Gly Gly Arg Lys  Pro Ala Arg Leu Ile  Val Phe Pro 
    2570                 2575                 2580             


Asp Leu  Gly Val Arg Val Cys  Glu Lys Met Ala Leu  Tyr Asp Val 
    2585                 2590                 2595             


Val Ser  Lys Leu Pro Leu Ala  Val Met Gly Ser Ser  Tyr Gly Phe 
    2600                 2605                 2610             


Gln Tyr  Ser Pro Gly Gln Arg  Val Glu Phe Leu Val  Gln Ala Trp 
    2615                 2620                 2625             


Lys Ser  Lys Lys Thr Pro Met  Gly Phe Ser Tyr Asp  Thr Arg Cys 
    2630                 2635                 2640             


Phe Asp  Ser Thr Val Thr Glu  Ser Asp Ile Arg Thr  Glu Glu Ala 
    2645                 2650                 2655             


Ile Tyr  Gln Cys Cys Asp Leu  Asp Pro Gln Ala Arg  Val Ala Ile 
    2660                 2665                 2670             


Lys Ser  Leu Thr Glu Arg Leu  Tyr Val Gly Gly Pro  Leu Thr Asn 
    2675                 2680                 2685             


Ser Arg  Gly Glu Asn Cys Gly  Tyr Arg Arg Cys Arg  Ala Ser Gly 
    2690                 2695                 2700             


Val Leu  Thr Thr Ser Cys Gly  Asn Thr Leu Thr Cys  Tyr Ile Lys 
    2705                 2710                 2715             


Ala Arg  Ala Ala Cys Arg Ala  Ala Gly Leu Gln Asp  Cys Thr Met 
    2720                 2725                 2730             


Leu Val  Cys Gly Asp Asp Leu  Val Val Ile Cys Glu  Ser Ala Gly 
    2735                 2740                 2745             


Val Gln  Glu Asp Ala Ala Ser  Leu Arg Ala Phe Thr  Glu Ala Met 
    2750                 2755                 2760             


Thr Arg  Tyr Ser Ala Pro Pro  Gly Asp Pro Pro Gln  Pro Glu Tyr 
    2765                 2770                 2775             


Asp Leu  Glu Leu Ile Thr Ser  Cys Ser Ser Asn Val  Ser Val Ala 
    2780                 2785                 2790             


His Asp  Gly Ala Gly Lys Arg  Val Tyr Tyr Leu Thr  Arg Asp Pro 
    2795                 2800                 2805             


Thr Thr  Pro Leu Ala Arg Ala  Ala Trp Glu Thr Ala  Arg His Thr 
    2810                 2815                 2820             


Pro Val  Asn Ser Trp Leu Gly  Asn Ile Ile Met Phe  Ala Pro Thr 
    2825                 2830                 2835             


Leu Trp  Ala Arg Met Ile Leu  Met Thr His Phe Phe  Ser Val Leu 
    2840                 2845                 2850             


Ile Ala  Arg Asp Gln Leu Glu  Gln Ala Leu Asp Cys  Glu Ile Tyr 
    2855                 2860                 2865             


Gly Ala  Cys Tyr Ser Ile Glu  Pro Leu Asp Leu Pro  Pro Ile Ile 
    2870                 2875                 2880             


Gln Arg  Leu His Gly Leu Ser  Ala Phe Ser Leu His  Ser Tyr Ser 
    2885                 2890                 2895             


Pro Gly  Glu Ile Asn Arg Val  Ala Ala Cys Leu Arg  Lys Leu Gly 
    2900                 2905                 2910             


Val Pro  Pro Leu Arg Ala Trp  Arg His Arg Ala Arg  Ser Val Arg 
    2915                 2920                 2925             


Ala Arg  Leu Leu Ser Arg Gly  Gly Arg Ala Ala Ile  Cys Gly Lys 
    2930                 2935                 2940             


Tyr Leu  Phe Asn Trp Ala Val  Arg Thr Lys Leu Lys  Leu Thr Pro 
    2945                 2950                 2955             


Ile Ala  Ala Ala Gly Gln Leu  Asp Leu Ser Gly Trp  Phe Thr Ala 
    2960                 2965                 2970             


Gly Tyr  Ser Gly Gly Asp Ile  Tyr His Ser Val Ser  His Ala Arg 
    2975                 2980                 2985             


Pro Arg  Trp Phe Trp Phe Cys  Leu Leu Leu Leu Ala  Ala Gly Val 
    2990                 2995                 3000             


Gly Ile  Tyr Leu Leu Pro Asn  Arg Xaa 
    3005                 3010         


<210>  98
<211>  3008
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic Sequence


<220>
<221>  misc_feature
<222>  (3008)..(3008)
<223>  Xaa can be any amino acid

<400>  98

Met Ser Thr Asn Pro Lys Pro Gln Arg Lys Thr Lys Arg Asn Thr Asn 
1               5                   10                  15      


Arg Arg Pro Gln Asp Val Lys Phe Pro Gly Gly Gly Gln Ile Val Gly 
            20                  25                  30          


Gly Val Tyr Leu Leu Pro Arg Arg Gly Pro Arg Leu Gly Val Arg Ala 
        35                  40                  45              


Thr Arg Lys Thr Ser Glu Arg Ser Gln Pro Arg Gly Arg Arg Gln Pro 
    50                  55                  60                  


Ile Pro Lys Ala Arg Arg Pro Glu Gly Arg Ala Trp Ala Gln Pro Gly 
65                  70                  75                  80  


Tyr Pro Trp Pro Leu Tyr Gly Asn Glu Gly Met Gly Trp Ala Gly Trp 
                85                  90                  95      


Leu Leu Ser Pro Arg Gly Ser Arg Pro Ser Trp Gly Pro Thr Asp Pro 
            100                 105                 110         


Arg Arg Arg Ser Arg Asn Leu Gly Lys Val Ile Asp Thr Leu Thr Cys 
        115                 120                 125             


Gly Phe Ala Asp Leu Met Gly Tyr Ile Pro Leu Val Gly Ala Pro Leu 
    130                 135                 140                 


Gly Gly Ala Ala Arg Ala Leu Ala His Gly Val Arg Val Leu Glu Asp 
145                 150                 155                 160 


Gly Val Asn Tyr Ala Thr Gly Asn Leu Pro Gly Cys Ser Phe Ser Ile 
                165                 170                 175     


Phe Leu Leu Ala Leu Leu Ser Cys Leu Thr Ile Pro Ala Ser Ala Tyr 
            180                 185                 190         


Glu Val Arg Asn Val Ser Gly Val Tyr His Val Thr Asn Asp Cys Ser 
        195                 200                 205             


Asn Ser Ser Ile Val Tyr Glu Ala Ala Asp Met Ile Met His Thr Pro 
    210                 215                 220                 


Gly Cys Val Pro Cys Val Arg Glu Asn Asn Ser Ser Arg Cys Trp Val 
225                 230                 235                 240 


Ala Leu Thr Pro Thr Leu Ala Ala Arg Asn Ala Ser Val Pro Thr Thr 
                245                 250                 255     


Thr Ile Arg Arg His Val Asp Leu Leu Val Gly Ala Ala Ala Phe Cys 
            260                 265                 270         


Ser Ala Met Tyr Val Gly Asp Leu Cys Gly Ser Val Phe Leu Val Ser 
        275                 280                 285             


Gln Leu Phe Thr Phe Ser Pro Arg Arg His Glu Thr Val Gln Asp Cys 
    290                 295                 300                 


Asn Cys Ser Ile Tyr Pro Gly His Val Ser Gly His Arg Met Ala Trp 
305                 310                 315                 320 


Asp Met Met Met Asn Trp Ser Pro Thr Thr Ala Leu Val Val Ser Gln 
                325                 330                 335     


Leu Leu Arg Ile Pro Gln Ala Val Val Asp Met Val Ala Gly Ala His 
            340                 345                 350         


Trp Gly Val Leu Ala Gly Leu Ala Tyr Tyr Ser Met Val Gly Asn Trp 
        355                 360                 365             


Ala Lys Val Leu Ile Val Met Leu Leu Phe Ala Gly Val Asp Gly Thr 
    370                 375                 380                 


His Val Thr Gly Gly Ala Ala Ala Arg Thr Thr Ser Gly Phe Thr Ser 
385                 390                 395                 400 


Leu Phe Ser Pro Gly Pro Ser Gln Lys Ile Gln Leu Ile Asn Thr Asn 
                405                 410                 415     


Gly Ser Trp His Ile Asn Arg Thr Ala Leu Asn Cys Asn Asp Ser Leu 
            420                 425                 430         


Gln Thr Gly Phe Leu Ala Ala Leu Phe Tyr Thr His Lys Phe Asn Ser 
        435                 440                 445             


Ser Gly Cys Pro Glu Arg Met Ala Ser Cys Arg Pro Ile Asp Lys Phe 
    450                 455                 460                 


Ala Gln Gly Trp Gly Pro Ile Thr Tyr Ala Glu Pro Ser Ser Asp Gln 
465                 470                 475                 480 


Arg Pro Tyr Cys Trp His Tyr Ala Pro Arg Pro Cys Gly Ile Val Pro 
                485                 490                 495     


Ala Ser Gln Val Cys Gly Pro Val Tyr Cys Phe Thr Pro Ser Pro Val 
            500                 505                 510         


Val Val Gly Thr Thr Asp Arg Phe Gly Val Pro Thr Tyr Ser Trp Gly 
        515                 520                 525             


Glu Asn Glu Thr Asp Val Leu Leu Leu Asn Asn Thr Arg Pro Pro Gln 
    530                 535                 540                 


Gly Asn Trp Phe Gly Cys Thr Trp Met Asn Ser Thr Gly Phe Thr Lys 
545                 550                 555                 560 


Thr Cys Gly Gly Pro Pro Cys Asn Ile Gly Gly Val Gly Asn Asn Thr 
                565                 570                 575     


Leu Thr Cys Pro Thr Asp Cys Phe Arg Lys His Pro Glu Ala Thr Tyr 
            580                 585                 590         


Thr Lys Cys Gly Ser Gly Pro Trp Leu Thr Pro Arg Cys Leu Val Asp 
        595                 600                 605             


Tyr Pro Tyr Arg Leu Trp His Tyr Pro Cys Thr Val Asn Phe Thr Ile 
    610                 615                 620                 


Phe Lys Val Arg Met Tyr Val Gly Gly Val Glu His Arg Leu Asn Ala 
625                 630                 635                 640 


Ala Cys Asn Trp Thr Arg Gly Glu Arg Cys Asp Leu Glu Asp Arg Asp 
                645                 650                 655     


Arg Ser Glu Leu Ser Pro Leu Leu Leu Ser Thr Thr Glu Trp Gln Ile 
            660                 665                 670         


Leu Pro Cys Ser Phe Thr Thr Leu Pro Ala Leu Ser Thr Gly Leu Ile 
        675                 680                 685             


His Leu His Gln Asn Ile Val Asp Val Gln Tyr Leu Tyr Gly Ile Gly 
    690                 695                 700                 


Ser Ala Val Val Ser Phe Ala Ile Lys Trp Glu Tyr Val Leu Leu Leu 
705                 710                 715                 720 


Phe Leu Leu Leu Ala Asp Ala Arg Val Cys Ala Cys Leu Trp Met Met 
                725                 730                 735     


Leu Leu Ile Ala Gln Ala Glu Ala Ala Leu Glu Asn Leu Val Val Leu 
            740                 745                 750         


Asn Ala Ala Ser Val Ala Gly Ala His Gly Ile Leu Ser Phe Leu Val 
        755                 760                 765             


Phe Phe Cys Ala Ala Trp Tyr Ile Lys Gly Arg Leu Val Pro Gly Ala 
    770                 775                 780                 


Ala Tyr Ala Phe Tyr Gly Val Trp Pro Leu Leu Leu Leu Leu Leu Ala 
785                 790                 795                 800 


Leu Pro Pro Arg Ala Tyr Ala Met Asp Arg Glu Met Ala Ala Ser Cys 
                805                 810                 815     


Gly Gly Ala Val Phe Val Gly Leu Ala Leu Leu Thr Leu Ser Pro His 
            820                 825                 830         


Tyr Lys Val Phe Leu Ala Arg Leu Ile Trp Trp Leu Gln Tyr Phe Ile 
        835                 840                 845             


Thr Arg Ala Glu Ala His Leu Gln Val Trp Ile Pro Pro Leu Asn Val 
    850                 855                 860                 


Arg Gly Gly Arg Asp Ala Ile Ile Leu Leu Thr Cys Ala Val His Pro 
865                 870                 875                 880 


Glu Leu Ile Phe Asp Ile Thr Lys Leu Leu Leu Ala Ile Leu Gly Pro 
                885                 890                 895     


Leu Met Val Leu Gln Ala Gly Ile Thr Arg Val Pro Tyr Phe Val Arg 
            900                 905                 910         


Ala Gln Gly Leu Ile Arg Ala Cys Met Leu Val Arg Lys Val Ala Gly 
        915                 920                 925             


Gly His Tyr Val Gln Met Ala Phe Met Lys Leu Ala Ala Leu Thr Gly 
    930                 935                 940                 


Thr Tyr Val Tyr Asp His Leu Thr Pro Leu Arg Asp Trp Ala His Ala 
945                 950                 955                 960 


Gly Leu Arg Asp Leu Ala Val Ala Val Glu Pro Val Val Phe Ser Asp 
                965                 970                 975     


Met Glu Thr Lys Ile Ile Thr Trp Gly Ala Asp Thr Ala Ala Cys Gly 
            980                 985                 990         


Asp Ile Ile Leu Gly Leu Pro Val  Ser Ala Arg Arg Gly  Arg Glu Ile 
        995                 1000                 1005             


Leu Leu  Gly Pro Ala Asp Ser  Leu Glu Gly Gln Gly  Trp Arg Leu 
    1010                 1015                 1020             


Leu Ala  Pro Ile Thr Ala Tyr  Ser Gln Gln Thr Arg  Gly Leu Leu 
    1025                 1030                 1035             


Gly Cys  Ile Ile Thr Ser Leu  Thr Gly Arg Asp Lys  Asn Gln Val 
    1040                 1045                 1050             


Glu Gly  Glu Val Gln Val Val  Ser Thr Ala Thr Gln  Ser Phe Leu 
    1055                 1060                 1065             


Ala Thr  Cys Val Asn Gly Val  Cys Trp Thr Val Tyr  His Gly Ala 
    1070                 1075                 1080             


Gly Ser  Lys Thr Leu Ala Gly  Pro Lys Gly Pro Ile  Thr Gln Met 
    1085                 1090                 1095             


Tyr Thr  Asn Val Asp Gln Asp  Leu Val Gly Trp Gln  Ala Pro Pro 
    1100                 1105                 1110             


Gly Ala  Arg Ser Leu Thr Pro  Cys Thr Cys Gly Ser  Ser Asp Leu 
    1115                 1120                 1125             


Tyr Leu  Val Thr Arg His Ala  Asp Val Ile Pro Val  Arg Arg Arg 
    1130                 1135                 1140             


Gly Asp  Ser Arg Gly Ser Leu  Leu Ser Pro Arg Pro  Val Ser Tyr 
    1145                 1150                 1155             


Leu Lys  Gly Ser Ser Gly Gly  Pro Leu Leu Cys Pro  Ser Gly His 
    1160                 1165                 1170             


Ala Val  Gly Ile Phe Arg Ala  Ala Val Cys Thr Arg  Gly Val Ala 
    1175                 1180                 1185             


Lys Ala  Val Asp Phe Val Pro  Val Glu Ser Met Glu  Thr Thr Met 
    1190                 1195                 1200             


Arg Ser  Pro Val Phe Thr Asp  Asn Ser Ser Pro Pro  Ala Val Pro 
    1205                 1210                 1215             


Gln Thr  Phe Gln Val Ala His  Leu His Ala Pro Thr  Gly Ser Gly 
    1220                 1225                 1230             


Lys Ser  Thr Lys Val Pro Ala  Ala Tyr Ala Ala Gln  Gly Tyr Lys 
    1235                 1240                 1245             


Val Leu  Val Leu Asn Pro Ser  Val Ala Ala Thr Leu  Gly Phe Gly 
    1250                 1255                 1260             


Ala Tyr  Met Ser Lys Ala His  Gly Val Asp Pro Asn  Ile Arg Thr 
    1265                 1270                 1275             


Gly Val  Arg Thr Ile Thr Thr  Gly Ala Pro Ile Thr  Tyr Ser Thr 
    1280                 1285                 1290             


Tyr Gly  Lys Phe Leu Ala Asp  Gly Gly Cys Ser Gly  Gly Ala Tyr 
    1295                 1300                 1305             


Asp Ile  Ile Ile Cys Asp Glu  Cys His Ser Thr Asp  Ser Thr Thr 
    1310                 1315                 1320             


Ile Leu  Gly Ile Gly Thr Val  Leu Asp Gln Ala Glu  Thr Ala Gly 
    1325                 1330                 1335             


Ala Arg  Leu Val Val Leu Ala  Thr Ala Thr Pro Pro  Gly Ser Val 
    1340                 1345                 1350             


Thr Val  Pro His Pro Asn Ile  Glu Glu Val Ala Leu  Ser Asn Thr 
    1355                 1360                 1365             


Gly Glu  Ile Pro Phe Tyr Gly  Lys Ala Ile Pro Ile  Glu Thr Ile 
    1370                 1375                 1380             


Lys Gly  Gly Arg His Leu Ile  Phe Cys His Ser Lys  Lys Lys Cys 
    1385                 1390                 1395             


Asp Glu  Leu Ala Ala Lys Leu  Ser Gly Leu Gly Leu  Asn Ala Val 
    1400                 1405                 1410             


Ala Tyr  Tyr Arg Gly Leu Asp  Val Ser Val Ile Pro  Thr Ser Gly 
    1415                 1420                 1425             


Asp Val  Val Val Val Ala Thr  Asp Ala Leu Met Thr  Gly Phe Thr 
    1430                 1435                 1440             


Gly Asp  Phe Asp Ser Val Ile  Asp Cys Asn Thr Cys  Val Thr Gln 
    1445                 1450                 1455             


Thr Val  Asp Phe Ser Leu Asp  Pro Thr Phe Thr Ile  Glu Thr Thr 
    1460                 1465                 1470             


Thr Val  Pro Gln Asp Ala Val  Ser Arg Ser Gln Arg  Arg Gly Arg 
    1475                 1480                 1485             


Thr Gly  Arg Gly Arg Arg Gly  Ile Tyr Arg Phe Val  Thr Pro Gly 
    1490                 1495                 1500             


Glu Arg  Pro Ser Gly Met Phe  Asp Ser Ser Val Leu  Cys Glu Cys 
    1505                 1510                 1515             


Tyr Asp  Ala Gly Cys Ala Trp  Tyr Glu Leu Thr Pro  Ala Glu Thr 
    1520                 1525                 1530             


Ser Val  Arg Leu Arg Ala Tyr  Leu Asn Thr Pro Gly  Leu Pro Val 
    1535                 1540                 1545             


Cys Gln  Asp His Leu Glu Phe  Trp Glu Ser Val Phe  Thr Gly Leu 
    1550                 1555                 1560             


Thr His  Ile Asp Ala His Phe  Leu Ser Gln Thr Lys  Gln Ala Gly 
    1565                 1570                 1575             


Asp Asn  Phe Pro Tyr Leu Val  Ala Tyr Gln Ala Thr  Val Cys Ala 
    1580                 1585                 1590             


Arg Ala  Gln Ala Pro Pro Pro  Ser Trp Asp Gln Met  Trp Lys Cys 
    1595                 1600                 1605             


Leu Ile  Arg Leu Lys Pro Thr  Leu His Gly Pro Thr  Pro Leu Leu 
    1610                 1615                 1620             


Tyr Arg  Leu Gly Ala Val Gln  Asn Glu Val Thr Leu  Thr His Pro 
    1625                 1630                 1635             


Ile Thr  Lys Tyr Ile Met Ala  Cys Met Ser Ala Asp  Leu Glu Val 
    1640                 1645                 1650             


Val Thr  Ser Thr Trp Val Leu  Val Gly Gly Val Leu  Ala Ala Leu 
    1655                 1660                 1665             


Ala Ala  Tyr Cys Leu Thr Thr  Gly Ser Val Val Ile  Val Gly Arg 
    1670                 1675                 1680             


Ile Ile  Leu Ser Gly Lys Pro  Ala Ile Ile Pro Asp  Arg Glu Val 
    1685                 1690                 1695             


Leu Tyr  Gln Glu Phe Asp Glu  Met Glu Glu Cys Ala  Ser His Leu 
    1700                 1705                 1710             


Pro Tyr  Ile Glu Gln Gly Met  Gln Leu Ala Glu Gln  Phe Lys Gln 
    1715                 1720                 1725             


Lys Ala  Leu Gly Leu Leu Gln  Thr Ala Thr Lys Gln  Ala Glu Ala 
    1730                 1735                 1740             


Ala Ala  Pro Val Val Glu Ser  Lys Trp Arg Ala Leu  Glu Phe Trp 
    1745                 1750                 1755             


Ala Lys  His Met Trp Asn Phe  Ile Ser Gly Ile Gln  Tyr Leu Ala 
    1760                 1765                 1770             


Gly Leu  Ser Thr Leu Pro Gly  Asn Pro Ala Ile Ala  Ser Leu Met 
    1775                 1780                 1785             


Ala Phe  Thr Ala Ser Ile Thr  Ser Pro Leu Thr Thr  Gln His Thr 
    1790                 1795                 1800             


Leu Leu  Phe Asn Ile Leu Gly  Gly Trp Val Ala Ala  Gln Leu Ala 
    1805                 1810                 1815             


Pro Pro  Ser Ala Ala Ser Ala  Phe Val Gly Ala Gly  Ile Ala Gly 
    1820                 1825                 1830             


Ala Ala  Val Gly Ser Ile Gly  Leu Gly Lys Val Leu  Val Asp Ile 
    1835                 1840                 1845             


Leu Ala  Gly Tyr Gly Ala Gly  Val Ala Gly Ala Leu  Val Ala Phe 
    1850                 1855                 1860             


Lys Val  Met Ser Gly Glu Met  Pro Ser Thr Glu Asp  Leu Val Asn 
    1865                 1870                 1875             


Leu Leu  Pro Ala Ile Leu Ser  Pro Gly Ala Leu Val  Val Gly Val 
    1880                 1885                 1890             


Val Cys  Ala Ala Ile Leu Arg  Arg His Val Gly Pro  Gly Glu Gly 
    1895                 1900                 1905             


Ala Val  Gln Trp Met Asn Arg  Leu Ile Ala Phe Ala  Ser Arg Gly 
    1910                 1915                 1920             


Asn His  Val Ser Pro Thr His  Tyr Val Pro Glu Ser  Asp Ala Ala 
    1925                 1930                 1935             


Ala Arg  Val Thr Gln Ile Leu  Ser Ser Leu Thr Ile  Thr Gln Leu 
    1940                 1945                 1950             


Leu Lys  Arg Leu His Gln Trp  Ile Asn Glu Asp Cys  Ser Thr Pro 
    1955                 1960                 1965             


Cys Ser  Gly Ser Trp Leu Arg  Asp Val Trp Asp Trp  Ile Cys Thr 
    1970                 1975                 1980             


Val Leu  Thr Asp Phe Lys Thr  Trp Leu Gln Ser Lys  Leu Leu Pro 
    1985                 1990                 1995             


Arg Leu  Pro Gly Val Pro Phe  Leu Ser Cys Gln Arg  Gly Tyr Lys 
    2000                 2005                 2010             


Gly Val  Trp Arg Gly Asp Gly  Ile Met Gln Thr Thr  Cys Pro Cys 
    2015                 2020                 2025             


Gly Ala  Gln Ile Thr Gly His  Val Lys Asn Gly Ser  Met Arg Ile 
    2030                 2035                 2040             


Val Gly  Pro Lys Thr Cys Ser  Asn Thr Trp His Gly  Thr Phe Pro 
    2045                 2050                 2055             


Ile Asn  Ala Tyr Thr Thr Gly  Pro Cys Thr Pro Ser  Pro Ala Pro 
    2060                 2065                 2070             


Asn Tyr  Ser Arg Ala Leu Trp  Arg Val Ala Ala Glu  Glu Tyr Val 
    2075                 2080                 2085             


Glu Val  Thr Arg Val Gly Asp  Phe His Tyr Val Thr  Gly Met Thr 
    2090                 2095                 2100             


Thr Asp  Asn Val Lys Cys Pro  Cys Gln Val Pro Ala  Pro Glu Phe 
    2105                 2110                 2115             


Phe Thr  Glu Val Asp Gly Val  Arg Leu His Arg Tyr  Ala Pro Ala 
    2120                 2125                 2130             


Cys Lys  Pro Leu Leu Arg Glu  Glu Val Thr Phe Gln  Val Gly Leu 
    2135                 2140                 2145             


Asn Gln  Tyr Leu Val Gly Ser  Gln Leu Pro Cys Glu  Pro Glu Pro 
    2150                 2155                 2160             


Asp Val  Ala Val Leu Thr Ser  Met Leu Thr Asp Pro  Ser His Ile 
    2165                 2170                 2175             


Thr Ala  Glu Thr Ala Lys Arg  Arg Leu Ala Arg Gly  Ser Pro Pro 
    2180                 2185                 2190             


Ser Leu  Ala Ser Ser Ser Ala  Ser Gln Leu Ser Ala  Pro Ser Leu 
    2195                 2200                 2205             


Lys Ala  Thr Cys Thr Thr Arg  His Asp Ser Pro Asp  Ala Asp Leu 
    2210                 2215                 2220             


Ile Glu  Ala Asn Leu Leu Trp  Arg Gln Glu Met Gly  Gly Asn Ile 
    2225                 2230                 2235             


Thr Arg  Val Glu Ser Glu Asn  Lys Val Val Ile Leu  Asp Ser Phe 
    2240                 2245                 2250             


Asp Pro  Leu Arg Ala Glu Glu  Asp Glu Arg Glu Val  Ser Val Pro 
    2255                 2260                 2265             


Ala Glu  Ile Leu Arg Lys Ser  Arg Lys Phe Pro Pro  Ala Met Pro 
    2270                 2275                 2280             


Ile Trp  Ala Arg Pro Asp Tyr  Asn Pro Pro Leu Leu  Glu Ser Trp 
    2285                 2290                 2295             


Lys Asp  Pro Asp Tyr Val Pro  Pro Val Val His Gly  Cys Pro Leu 
    2300                 2305                 2310             


Pro Pro  Thr Lys Ala Pro Pro  Ile Pro Pro Pro Arg  Arg Lys Arg 
    2315                 2320                 2325             


Thr Val  Val Leu Thr Glu Ser  Thr Val Ser Ser Ala  Leu Ala Glu 
    2330                 2335                 2340             


Leu Ala  Thr Lys Thr Phe Gly  Ser Ser Glu Ser Ser  Ala Val Asp 
    2345                 2350                 2355             


Ser Gly  Thr Ala Thr Ala Pro  Pro Asp Gln Pro Ser  Asp Asp Gly 
    2360                 2365                 2370             


Asp Ala  Gly Ser Asp Val Glu  Ser Tyr Ser Ser Met  Pro Pro Leu 
    2375                 2380                 2385             


Glu Gly  Glu Pro Gly Asp Pro  Asp Leu Ser Asp Gly  Ser Trp Ser 
    2390                 2395                 2400             


Thr Val  Ser Glu Glu Ala Ser  Glu Asp Val Val Cys  Cys Ser Met 
    2405                 2410                 2415             


Ser Tyr  Thr Trp Thr Gly Ala  Leu Ile Thr Pro Cys  Ala Ala Glu 
    2420                 2425                 2430             


Glu Ser  Lys Leu Pro Ile Asn  Ala Leu Ser Asn Ser  Leu Leu Arg 
    2435                 2440                 2445             


His His  Asn Met Val Tyr Ala  Thr Thr Ser Arg Ser  Ala Ser Gln 
    2450                 2455                 2460             


Arg Gln  Lys Lys Val Thr Phe  Asp Arg Leu Gln Val  Leu Asp Asp 
    2465                 2470                 2475             


His Tyr  Arg Asp Val Leu Lys  Glu Met Lys Ala Lys  Ala Ser Thr 
    2480                 2485                 2490             


Val Lys  Ala Lys Leu Leu Ser  Val Glu Glu Ala Cys  Lys Leu Thr 
    2495                 2500                 2505             


Pro Pro  His Ser Ala Arg Ser  Lys Phe Gly Tyr Gly  Ala Lys Asp 
    2510                 2515                 2520             


Val Arg  Asn Leu Ser Ser Lys  Ala Val Asn His Ile  Arg Ser Val 
    2525                 2530                 2535             


Trp Lys  Asp Leu Leu Glu Asp  Thr Glu Thr Pro Ile  Asp Thr Thr 
    2540                 2545                 2550             


Ile Met  Ala Lys Asn Glu Val  Phe Cys Val Gln Pro  Glu Lys Gly 
    2555                 2560                 2565             


Gly Arg  Lys Pro Ala Arg Leu  Ile Val Phe Pro Asp  Leu Gly Val 
    2570                 2575                 2580             


Arg Val  Cys Glu Lys Met Ala  Leu Tyr Asp Val Val  Ser Thr Leu 
    2585                 2590                 2595             


Pro Gln  Ala Val Met Gly Ser  Ser Tyr Gly Phe Gln  Tyr Ser Pro 
    2600                 2605                 2610             


Gly Gln  Arg Val Glu Phe Leu  Val Asn Ala Trp Lys  Ser Lys Lys 
    2615                 2620                 2625             


Cys Pro  Met Gly Phe Ala Tyr  Asp Thr Arg Cys Phe  Asp Ser Thr 
    2630                 2635                 2640             


Val Thr  Glu Ser Asp Ile Arg  Val Glu Glu Ser Ile  Tyr Gln Cys 
    2645                 2650                 2655             


Cys Asp  Leu Ala Pro Glu Ala  Arg Gln Ala Ile Arg  Ser Leu Thr 
    2660                 2665                 2670             


Glu Arg  Leu Tyr Ile Gly Gly  Pro Leu Thr Asn Ser  Lys Gly Gln 
    2675                 2680                 2685             


Asn Cys  Gly Tyr Arg Arg Cys  Arg Ala Ser Gly Val  Leu Thr Thr 
    2690                 2695                 2700             


Ser Cys  Gly Asn Thr Leu Thr  Cys Tyr Leu Lys Ala  Ser Ala Ala 
    2705                 2710                 2715             


Cys Arg  Ala Ala Lys Leu Gln  Asp Cys Thr Met Leu  Val Cys Gly 
    2720                 2725                 2730             


Asp Asp  Leu Val Val Ile Cys  Glu Ser Ala Gly Thr  Gln Glu Asp 
    2735                 2740                 2745             


Ala Ala  Ser Leu Arg Val Phe  Thr Glu Ala Met Thr  Arg Tyr Ser 
    2750                 2755                 2760             


Ala Pro  Pro Gly Asp Pro Pro  Gln Pro Glu Tyr Asp  Leu Glu Leu 
    2765                 2770                 2775             


Ile Thr  Ser Cys Ser Ser Asn  Val Ser Val Ala His  Asp Ala Ser 
    2780                 2785                 2790             


Gly Lys  Arg Val Tyr Tyr Leu  Thr Arg Asp Pro Thr  Thr Pro Leu 
    2795                 2800                 2805             


Ala Arg  Ala Ala Trp Glu Thr  Ala Arg His Thr Pro  Val Asn Ser 
    2810                 2815                 2820             


Trp Leu  Gly Asn Ile Ile Met  Tyr Ala Pro Thr Leu  Trp Ala Arg 
    2825                 2830                 2835             


Met Ile  Leu Met Thr His Phe  Phe Ser Ile Leu Leu  Ala Gln Glu 
    2840                 2845                 2850             


Gln Leu  Glu Lys Ala Leu Asp  Cys Gln Ile Tyr Gly  Ala Cys Tyr 
    2855                 2860                 2865             


Ser Ile  Glu Pro Leu Asp Leu  Pro Gln Ile Ile Gln  Arg Leu His 
    2870                 2875                 2880             


Gly Leu  Ser Ala Phe Ser Leu  His Ser Tyr Ser Pro  Gly Glu Ile 
    2885                 2890                 2895             


Asn Arg  Val Ala Ser Cys Leu  Arg Lys Leu Gly Val  Pro Pro Leu 
    2900                 2905                 2910             


Arg Val  Trp Arg His Arg Ala  Arg Ser Val Arg Ala  Lys Leu Leu 
    2915                 2920                 2925             


Ser Gln  Gly Gly Arg Ala Ala  Thr Cys Gly Lys Tyr  Leu Phe Asn 
    2930                 2935                 2940             


Trp Ala  Val Arg Thr Lys Leu  Lys Leu Thr Pro Ile  Pro Ala Ala 
    2945                 2950                 2955             


Ser Gln  Leu Asp Leu Ser Gly  Trp Phe Val Ala Gly  Tyr Ser Gly 
    2960                 2965                 2970             


Gly Asp  Ile Tyr His Ser Leu  Ser Arg Ala Arg Pro  Arg Trp Phe 
    2975                 2980                 2985             


Met Trp  Cys Leu Leu Leu Leu  Ser Val Gly Val Gly  Ile Tyr Leu 
    2990                 2995                 3000             


Leu Pro  Asn Arg Xaa 
    3005             


<210>  99
<211>  3034
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic Sequence


<220>
<221>  misc_feature
<222>  (250)..(250)
<223>  Xaa can be any amino acid

<220>
<221>  misc_feature
<222>  (406)..(406)
<223>  Xaa can be any amino acid

<220>
<221>  misc_feature
<222>  (408)..(409)
<223>  Xaa can be any amino acid

<220>
<221>  misc_feature
<222>  (3023)..(3023)
<223>  Xaa can be any amino acid

<400>  99

Met Ser Thr Asn Pro Lys Pro Gln Arg Lys Thr Lys Arg Asn Thr Asn 
1               5                   10                  15      


Arg Arg Pro Gln Asp Val Lys Phe Pro Gly Gly Gly Gln Ile Val Gly 
            20                  25                  30          


Gly Val Tyr Leu Leu Pro Arg Arg Gly Pro Arg Leu Gly Val Arg Ala 
        35                  40                  45              


Thr Arg Lys Thr Ser Glu Arg Ser Gln Pro Arg Gly Arg Arg Gln Pro 
    50                  55                  60                  


Ile Pro Lys Asp Arg Arg Ser Thr Gly Lys Ser Trp Gly Lys Pro Gly 
65                  70                  75                  80  


Tyr Pro Trp Pro Leu Tyr Gly Asn Glu Gly Leu Gly Trp Ala Gly Trp 
                85                  90                  95      


Leu Leu Ser Pro Arg Gly Ser Arg Pro Ser Trp Gly Pro Thr Asp Pro 
            100                 105                 110         


Arg His Arg Ser Arg Asn Val Gly Lys Val Ile Asp Thr Leu Thr Cys 
        115                 120                 125             


Gly Phe Ala Asp Leu Met Gly Tyr Ile Pro Val Val Gly Ala Pro Leu 
    130                 135                 140                 


Gly Gly Val Ala Arg Ala Leu Ala His Gly Val Arg Val Leu Glu Asp 
145                 150                 155                 160 


Gly Val Asn Tyr Ala Thr Gly Asn Leu Pro Gly Cys Ser Phe Ser Ile 
                165                 170                 175     


Phe Leu Leu Ala Leu Leu Ser Cys Ile Thr Val Pro Val Ser Ala Ala 
            180                 185                 190         


Gln Val Lys Asn Thr Ser Ser Ser Tyr Met Val Thr Asn Asp Cys Ser 
        195                 200                 205             


Asn Asp Ser Ile Thr Trp Gln Leu Gln Ala Ala Val Leu His Val Pro 
    210                 215                 220                 


Gly Cys Val Pro Cys Glu Lys Val Gly Asn Asn Thr Ser Arg Cys Trp 
225                 230                 235                 240 


Ile Pro Val Ser Pro Asn Val Ala Val Xaa Gln Pro Gly Ala Leu Thr 
                245                 250                 255     


Gln Gly Leu Arg Thr His Ile Asp Met Val Val Met Ser Ala Thr Leu 
            260                 265                 270         


Cys Ser Ala Leu Tyr Val Gly Asp Leu Cys Gly Gly Val Met Leu Ala 
        275                 280                 285             


Ala Gln Met Phe Ile Val Ser Pro Gln His His Trp Phe Val Gln Glu 
    290                 295                 300                 


Cys Asn Cys Ser Ile Tyr Pro Gly Thr Ile Thr Gly His Arg Met Ala 
305                 310                 315                 320 


Trp Asp Met Met Met Asn Trp Ser Pro Thr Ala Thr Met Ile Leu Ala 
                325                 330                 335     


Tyr Ala Met Arg Val Pro Glu Val Ile Ile Asp Ile Ile Ser Gly Ala 
            340                 345                 350         


His Trp Gly Val Met Phe Gly Leu Ala Tyr Phe Ser Met Gln Gly Ala 
        355                 360                 365             


Trp Ala Lys Val Val Val Ile Leu Leu Leu Ala Ala Gly Val Asp Ala 
    370                 375                 380                 


Gly Thr His Thr Val Gly Gly Ser Ala Ala His Thr Thr Ser Gly Leu 
385                 390                 395                 400 


Ala Gly Leu Phe Ser Xaa Gly Xaa Xaa Gln Asn Ile Gln Leu Ile Asn 
                405                 410                 415     


Thr Asn Gly Ser Trp His Ile Asn Arg Thr Ala Leu Asn Cys Asn Asp 
            420                 425                 430         


Ser Leu Asn Thr Gly Phe Leu Ala Ser Leu Phe Tyr Thr His Arg Phe 
        435                 440                 445             


Asn Ser Ser Gly Cys Pro Glu Arg Leu Ser Ala Cys Arg Asn Ile Glu 
    450                 455                 460                 


Ala Phe Arg Ile Gly Trp Gly Thr Leu Gln Tyr Glu Asp Asn Val Thr 
465                 470                 475                 480 


Asn Pro Glu Asp Met Arg Pro Tyr Cys Trp His Tyr Pro Pro Lys Gln 
                485                 490                 495     


Cys Gly Ile Val Pro Ala Arg Ser Val Cys Gly Pro Val Tyr Cys Phe 
            500                 505                 510         


Thr Pro Ser Pro Val Val Val Gly Thr Thr Asp Arg Leu Gly Val Pro 
        515                 520                 525             


Thr Tyr Thr Trp Gly Glu Asn Glu Thr Asp Val Phe Leu Leu Asn Ser 
    530                 535                 540                 


Thr Arg Pro Pro Gln Gly Ser Trp Phe Gly Cys Thr Trp Met Asn Ser 
545                 550                 555                 560 


Thr Gly Phe Thr Lys Thr Cys Gly Ala Pro Pro Cys Arg Ile Arg Ala 
                565                 570                 575     


Asp Phe Asn Ala Ser Thr Asp Leu Leu Cys Pro Thr Asp Cys Phe Arg 
            580                 585                 590         


Lys His Pro Glu Ala Thr Tyr Ile Lys Cys Gly Ser Gly Pro Trp Leu 
        595                 600                 605             


Thr Pro Arg Cys Leu Val Asp Tyr Pro Tyr Arg Leu Trp His Tyr Pro 
    610                 615                 620                 


Cys Thr Val Asn Tyr Thr Ile Phe Lys Ile Arg Met Tyr Val Gly Gly 
625                 630                 635                 640 


Val Glu His Arg Leu Thr Ala Ala Cys Asn Phe Thr Arg Gly Asp Arg 
                645                 650                 655     


Cys Asn Leu Glu Asp Arg Asp Arg Ser Gln Leu Ser Pro Leu Leu His 
            660                 665                 670         


Ser Thr Thr Glu Trp Ala Ile Leu Pro Cys Ser Tyr Ser Asp Leu Pro 
        675                 680                 685             


Ala Leu Ser Thr Gly Leu Leu His Leu His Gln Asn Ile Val Asp Val 
    690                 695                 700                 


Gln Tyr Met Tyr Gly Leu Ser Pro Ala Leu Thr Lys Tyr Val Val Arg 
705                 710                 715                 720 


Trp Glu Trp Val Val Leu Leu Phe Leu Leu Leu Ala Asp Ala Arg Val 
                725                 730                 735     


Cys Ala Cys Leu Trp Met Leu Ile Leu Leu Gly Gln Ala Glu Ala Ala 
            740                 745                 750         


Leu Glu Lys Leu Val Val Leu His Ala Ala Ser Ala Ala Ser Cys Asn 
        755                 760                 765             


Gly Phe Leu Tyr Phe Val Ile Phe Phe Val Ala Ala Trp Tyr Ile Lys 
    770                 775                 780                 


Gly Arg Ala Val Pro Leu Ala Ala Tyr Ser Leu Thr Gly Leu Trp Pro 
785                 790                 795                 800 


Phe Cys Leu Leu Leu Leu Ala Leu Pro Gln Gln Ala Tyr Ala Tyr Asp 
                805                 810                 815     


Ala Ser Val His Gly Gln Ile Gly Ala Ala Leu Leu Ile Leu Ile Thr 
            820                 825                 830         


Leu Phe Thr Leu Thr Pro Gly Tyr Lys Thr Leu Leu Ser Arg Cys Leu 
        835                 840                 845             


Trp Trp Leu Cys Tyr Leu Leu Thr Leu Gly Glu Ala Met Val Gln Glu 
    850                 855                 860                 


Trp Ala Pro Pro Met Gln Ala Arg Gly Gly Arg Asp Gly Ile Ile Trp 
865                 870                 875                 880 


Ala Ala Thr Ile Phe Cys Pro Gly Val Val Phe Asp Ile Thr Lys Trp 
                885                 890                 895     


Leu Leu Ala Val Leu Gly Pro Ala Tyr Leu Leu Arg Asp Ala Leu Thr 
            900                 905                 910         


Arg Val Pro Tyr Phe Val Arg Ala His Ala Leu Leu Arg Met Cys Thr 
        915                 920                 925             


Met Val Arg His Leu Ala Gly Gly Arg Tyr Val Gln Met Ala Leu Leu 
    930                 935                 940                 


Ala Leu Gly Arg Trp Thr Gly Thr Tyr Ile Tyr Asp His Leu Thr Pro 
945                 950                 955                 960 


Met Ser Asp Trp Ala Ala Ser Gly Leu Arg Asp Leu Ala Val Ala Val 
                965                 970                 975     


Glu Pro Ile Ile Phe Ser Pro Met Glu Lys Lys Val Ile Val Trp Gly 
            980                 985                 990         


Ala Glu Thr Ala Ala Cys Gly Asp  Ile Leu His Gly Leu  Pro Val Ser 
        995                 1000                 1005             


Ala Arg  Leu Gly Arg Glu Ile  Leu Leu Gly Pro Ala  Asp Gly Tyr 
    1010                 1015                 1020             


Thr Ser  Lys Gly Trp Arg Leu  Leu Ala Pro Ile Thr  Ala Tyr Ala 
    1025                 1030                 1035             


Gln Gln  Thr Arg Gly Leu Leu  Gly Ala Ile Val Val  Ser Met Thr 
    1040                 1045                 1050             


Gly Arg  Asp Lys Thr Glu Gln  Ala Gly Glu Ile Gln  Val Leu Ser 
    1055                 1060                 1065             


Thr Val  Thr Gln Ser Phe Leu  Gly Thr Ser Ile Ser  Gly Val Leu 
    1070                 1075                 1080             


Trp Thr  Val Tyr His Gly Ala  Gly Asn Lys Thr Leu  Ala Gly Ser 
    1085                 1090                 1095             


Arg Gly  Pro Val Thr Gln Met  Tyr Ser Ser Ala Glu  Gly Asp Leu 
    1100                 1105                 1110             


Val Gly  Trp Pro Ser Pro Pro  Gly Thr Lys Ser Leu  Glu Pro Cys 
    1115                 1120                 1125             


Thr Cys  Gly Ala Val Asp Leu  Tyr Leu Val Thr Arg  Asn Ala Asp 
    1130                 1135                 1140             


Val Ile  Pro Ala Arg Arg Arg  Gly Asp Lys Arg Gly  Ala Leu Leu 
    1145                 1150                 1155             


Ser Pro  Arg Pro Leu Ser Thr  Leu Lys Gly Ser Ser  Gly Gly Pro 
    1160                 1165                 1170             


Val Leu  Cys Pro Arg Gly His  Ala Val Gly Ile Phe  Arg Ala Ala 
    1175                 1180                 1185             


Val Cys  Ser Arg Gly Val Ala  Lys Ser Ile Asp Phe  Ile Pro Val 
    1190                 1195                 1200             


Glu Thr  Leu Asp Ile Val Thr  Arg Ser Pro Thr Phe  Ser Asp Asn 
    1205                 1210                 1215             


Ser Thr  Pro Pro Ala Val Pro  Gln Thr Tyr Gln Val  Gly Tyr Leu 
    1220                 1225                 1230             


His Ala  Pro Thr Gly Ser Gly  Lys Ser Thr Lys Val  Pro Val Ala 
    1235                 1240                 1245             


Tyr Ala  Ala Gln Gly Tyr Lys  Val Leu Val Leu Asn  Pro Ser Val 
    1250                 1255                 1260             


Ala Ala  Thr Leu Gly Phe Gly  Ala Tyr Leu Ser Lys  Ala His Gly 
    1265                 1270                 1275             


Ile Asn  Pro Asn Ile Arg Thr  Gly Val Arg Thr Val  Thr Thr Gly 
    1280                 1285                 1290             


Glu Ala  Ile Thr Tyr Ser Thr  Tyr Gly Lys Phe Leu  Ala Asp Gly 
    1295                 1300                 1305             


Gly Cys  Ala Gly Gly Ala Tyr  Asp Ile Ile Ile Cys  Asp Glu Cys 
    1310                 1315                 1320             


His Ala  Val Asp Ala Thr Thr  Ile Leu Gly Ile Gly  Thr Val Leu 
    1325                 1330                 1335             


Asp Gln  Ala Glu Thr Ala Gly  Val Arg Leu Thr Val  Leu Ala Thr 
    1340                 1345                 1350             


Ala Thr  Pro Pro Gly Ser Val  Thr Thr Pro His Pro  Asn Ile Glu 
    1355                 1360                 1365             


Glu Val  Ala Leu Gly Gln Glu  Gly Glu Ile Pro Phe  Tyr Gly Arg 
    1370                 1375                 1380             


Ala Ile  Pro Leu Ser Tyr Ile  Lys Gly Gly Arg His  Leu Ile Phe 
    1385                 1390                 1395             


Cys His  Ser Lys Lys Lys Cys  Asp Glu Leu Ala Ala  Ala Leu Arg 
    1400                 1405                 1410             


Gly Met  Gly Leu Asn Ala Val  Ala Tyr Tyr Arg Gly  Leu Asp Val 
    1415                 1420                 1425             


Ser Ile  Ile Pro Thr Gln Gly  Asp Val Val Val Val  Ala Thr Asp 
    1430                 1435                 1440             


Ala Leu  Met Thr Gly Tyr Thr  Gly Asp Phe Asp Ser  Val Ile Asp 
    1445                 1450                 1455             


Cys Asn  Val Ala Val Thr Gln  Val Val Asp Phe Ser  Leu Asp Pro 
    1460                 1465                 1470             


Thr Phe  Thr Ile Thr Thr Gln  Thr Val Pro Gln Asp  Ala Val Ser 
    1475                 1480                 1485             


Arg Ser  Gln Arg Arg Gly Arg  Thr Gly Arg Gly Arg  Leu Gly Ile 
    1490                 1495                 1500             


Tyr Arg  Tyr Val Ser Thr Gly  Glu Arg Ala Ser Gly  Met Phe Asp 
    1505                 1510                 1515             


Ser Val  Val Leu Cys Glu Cys  Tyr Asp Ala Gly Ala  Ala Trp Tyr 
    1520                 1525                 1530             


Glu Leu  Thr Pro Ala Glu Thr  Thr Val Arg Leu Arg  Ala Tyr Phe 
    1535                 1540                 1545             


Asn Thr  Pro Gly Leu Pro Val  Cys Gln Asp His Leu  Glu Phe Trp 
    1550                 1555                 1560             


Glu Ala  Val Phe Thr Gly Leu  Thr His Ile Asp Ala  His Phe Leu 
    1565                 1570                 1575             


Ser Gln  Thr Lys Gln Ser Gly  Glu Asn Phe Ala Tyr  Leu Val Ala 
    1580                 1585                 1590             


Tyr Gln  Ala Thr Val Cys Ala  Arg Ala Lys Ala Pro  Pro Pro Ser 
    1595                 1600                 1605             


Trp Asp  Val Met Trp Lys Cys  Leu Thr Arg Leu Lys  Pro Thr Leu 
    1610                 1615                 1620             


Val Gly  Pro Thr Pro Leu Leu  Tyr Arg Leu Gly Ser  Val Thr Asn 
    1625                 1630                 1635             


Glu Val  Thr Leu Thr His Pro  Val Thr Lys Tyr Ile  Ala Thr Cys 
    1640                 1645                 1650             


Met Gln  Ala Asp Leu Glu Val  Met Thr Ser Thr Trp  Val Leu Ala 
    1655                 1660                 1665             


Gly Gly  Val Leu Ala Ala Val  Ala Ala Tyr Cys Leu  Ala Thr Gly 
    1670                 1675                 1680             


Cys Val  Ser Ile Ile Gly Arg  Leu His Ile Asn Gln  Arg Ala Val 
    1685                 1690                 1695             


Val Ala  Pro Asp Lys Glu Val  Leu Tyr Glu Ala Phe  Asp Glu Met 
    1700                 1705                 1710             


Glu Glu  Cys Ala Ser Arg Ala  Ala Leu Ile Glu Glu  Gly Gln Arg 
    1715                 1720                 1725             


Ile Ala  Glu Met Leu Lys Ser  Lys Ile Gln Gly Leu  Leu Gln Gln 
    1730                 1735                 1740             


Ala Ser  Lys Gln Ala Gln Asp  Ile Gln Pro Ala Val  Gln Ala Ser 
    1745                 1750                 1755             


Trp Pro  Lys Val Glu Gln Phe  Trp Ala Lys His Met  Trp Asn Phe 
    1760                 1765                 1770             


Ile Ser  Gly Ile Gln Tyr Leu  Ala Gly Leu Ser Thr  Leu Pro Gly 
    1775                 1780                 1785             


Asn Pro  Ala Val Ala Ser Met  Met Ala Phe Ser Ala  Ala Leu Thr 
    1790                 1795                 1800             


Ser Pro  Leu Ser Thr Ser Thr  Thr Ile Leu Leu Asn  Ile Leu Gly 
    1805                 1810                 1815             


Gly Trp  Leu Ala Ser Gln Ile  Ala Pro Pro Ala Gly  Ala Thr Gly 
    1820                 1825                 1830             


Phe Val  Val Ser Gly Leu Val  Gly Ala Ala Val Gly  Ser Ile Gly 
    1835                 1840                 1845             


Leu Gly  Lys Val Leu Val Asp  Ile Leu Ala Gly Tyr  Gly Ala Gly 
    1850                 1855                 1860             


Ile Ser  Gly Ala Leu Val Ala  Phe Lys Ile Met Ser  Gly Glu Lys 
    1865                 1870                 1875             


Pro Ser  Met Glu Asp Val Val  Asn Leu Leu Pro Gly  Ile Leu Ser 
    1880                 1885                 1890             


Pro Gly  Ala Leu Val Val Gly  Val Ile Cys Ala Ala  Ile Leu Arg 
    1895                 1900                 1905             


Arg His  Val Gly Pro Gly Glu  Gly Ala Val Gln Trp  Met Asn Arg 
    1910                 1915                 1920             


Leu Ile  Ala Phe Ala Ser Arg  Gly Asn His Val Ala  Pro Thr His 
    1925                 1930                 1935             


Tyr Val  Thr Glu Ser Asp Ala  Ser Gln Arg Val Thr  Gln Leu Leu 
    1940                 1945                 1950             


Gly Ser  Leu Thr Ile Thr Ser  Leu Leu Arg Arg Leu  His Asn Trp 
    1955                 1960                 1965             


Ile Thr  Glu Asp Cys Pro Ile  Pro Cys Ala Gly Ser  Trp Leu Arg 
    1970                 1975                 1980             


Asp Val  Trp Asp Trp Val Cys  Thr Ile Leu Thr Asp  Phe Lys Asn 
    1985                 1990                 1995             


Trp Leu  Thr Ser Lys Leu Phe  Pro Lys Met Pro Gly  Leu Pro Phe 
    2000                 2005                 2010             


Ile Ser  Cys Gln Lys Gly Tyr  Lys Gly Val Trp Ala  Gly Thr Gly 
    2015                 2020                 2025             


Ile Met  Thr Thr Arg Cys Pro  Cys Gly Ala Asn Ile  Ser Gly Asn 
    2030                 2035                 2040             


Val Arg  Leu Gly Ser Met Arg  Ile Thr Gly Pro Lys  Thr Cys Met 
    2045                 2050                 2055             


Asn Thr  Trp Gln Gly Thr Phe  Pro Ile Asn Cys Tyr  Thr Glu Gly 
    2060                 2065                 2070             


Gln Cys  Val Pro Lys Pro Ala  Pro Asn Phe Lys Thr  Ala Ile Trp 
    2075                 2080                 2085             


Arg Val  Ala Ala Ser Glu Tyr  Ala Glu Val Thr Gln  His Gly Ser 
    2090                 2095                 2100             


Tyr Ser  Tyr Ile Thr Gly Leu  Thr Thr Asp Asn Leu  Lys Val Pro 
    2105                 2110                 2115             


Cys Gln  Leu Pro Ser Pro Glu  Phe Phe Ser Trp Val  Asp Gly Val 
    2120                 2125                 2130             


Gln Ile  His Arg Phe Ala Pro  Thr Pro Lys Pro Phe  Phe Arg Asp 
    2135                 2140                 2145             


Glu Val  Ser Phe Cys Val Gly  Leu Asn Ser Phe Val  Val Gly Ser 
    2150                 2155                 2160             


Gln Leu  Pro Cys Asp Pro Glu  Pro Asp Thr Asp Val  Leu Met Ser 
    2165                 2170                 2175             


Met Leu  Thr Asp Pro Ser His  Ile Thr Ala Glu Ala  Ala Ala Arg 
    2180                 2185                 2190             


Arg Leu  Ala Arg Gly Ser Pro  Pro Ser Glu Ala Ser  Ser Ser Ala 
    2195                 2200                 2205             


Ser Gln  Leu Ser Ala Pro Ser  Leu Arg Ala Thr Cys  Thr Thr His 
    2210                 2215                 2220             


Gly Lys  Thr Tyr Asp Val Asp  Met Val Asp Ala Asn  Leu Phe Met 
    2225                 2230                 2235             


Gly Gly  Asp Val Thr Arg Ile  Glu Ser Glu Ser Lys  Val Val Val 
    2240                 2245                 2250             


Leu Asp  Ser Leu Asp Pro Met  Ala Glu Glu Arg Ser  Asp Leu Glu 
    2255                 2260                 2265             


Pro Ser  Ile Pro Ser Glu Tyr  Met Leu Pro Arg Asn  Arg Phe Pro 
    2270                 2275                 2280             


Pro Ala  Leu Pro Ala Trp Ala  Arg Pro Asp Tyr Asn  Pro Pro Leu 
    2285                 2290                 2295             


Val Glu  Ser Trp Lys Arg Pro  Asp Tyr Gln Pro Pro  Thr Val Ala 
    2300                 2305                 2310             


Gly Cys  Ala Leu Pro Pro Pro  Lys Lys Thr Pro Thr  Pro Pro Pro 
    2315                 2320                 2325             


Arg Arg  Arg Arg Thr Val Gly  Leu Ser Glu Ser Thr  Ile Gly Asp 
    2330                 2335                 2340             


Ala Leu  Gln Gln Leu Ala Ile  Lys Thr Phe Gly Gln  Pro Pro Pro 
    2345                 2350                 2355             


Ser Gly  Asp Ser Gly Leu Ser  Thr Gly Ala Asp Ala  Ala Asp Ser 
    2360                 2365                 2370             


Gly Gly  Arg Thr Pro Pro Asp  Glu Leu Ala Leu Ser  Glu Thr Gly 
    2375                 2380                 2385             


Ser Ile  Ser Ser Met Pro Pro  Leu Glu Gly Glu Pro  Gly Asp Pro 
    2390                 2395                 2400             


Asp Leu  Glu Pro Glu Gln Val  Glu Leu Gln Pro Pro  Pro Gln Gly 
    2405                 2410                 2415             


Gly Glu  Val Ala Pro Gly Ser  Asp Ser Gly Ser Trp  Ser Thr Cys 
    2420                 2425                 2430             


Ser Glu  Glu Asp Asp Ser Val  Val Cys Cys Ser Met  Ser Tyr Ser 
    2435                 2440                 2445             


Trp Thr  Gly Ala Leu Ile Thr  Pro Cys Ser Pro Glu  Glu Glu Lys 
    2450                 2455                 2460             


Leu Pro  Ile Asn Pro Leu Ser  Asn Ser Leu Leu Arg  Tyr His Asn 
    2465                 2470                 2475             


Lys Val  Tyr Cys Thr Thr Ser  Lys Ser Ala Ser Leu  Arg Ala Lys 
    2480                 2485                 2490             


Lys Val  Thr Phe Asp Arg Met  Gln Val Leu Asp Ala  His Tyr Asp 
    2495                 2500                 2505             


Ser Val  Leu Lys Asp Ile Lys  Leu Ala Ala Ser Lys  Val Ser Ala 
    2510                 2515                 2520             


Arg Leu  Leu Thr Leu Glu Glu  Ala Cys Gln Leu Thr  Pro Pro His 
    2525                 2530                 2535             


Ser Ala  Arg Ser Lys Tyr Gly  Phe Gly Ala Lys Glu  Val Arg Ser 
    2540                 2545                 2550             


Leu Ser  Gly Arg Ala Val Asn  His Ile Lys Ser Val  Trp Lys Asp 
    2555                 2560                 2565             


Leu Leu  Glu Asp Ser Gln Thr  Pro Ile Pro Thr Thr  Ile Met Ala 
    2570                 2575                 2580             


Lys Asn  Glu Val Phe Cys Val  Asp Pro Thr Lys Gly  Gly Lys Lys 
    2585                 2590                 2595             


Ala Ala  Arg Leu Ile Val Tyr  Pro Asp Leu Gly Val  Arg Val Cys 
    2600                 2605                 2610             


Glu Lys  Met Ala Leu Tyr Asp  Val Thr Gln Lys Leu  Pro Gln Ala 
    2615                 2620                 2625             


Val Met  Gly Ala Ser Tyr Gly  Phe Gln Tyr Ser Pro  Ala Gln Arg 
    2630                 2635                 2640             


Val Glu  Phe Leu Leu Lys Ala  Trp Ala Glu Lys Lys  Asp Pro Met 
    2645                 2650                 2655             


Gly Phe  Ser Tyr Asp Thr Arg  Cys Phe Asp Ser Thr  Val Thr Glu 
    2660                 2665                 2670             


Arg Asp  Ile Arg Thr Glu Glu  Ser Ile Tyr Gln Ala  Cys Ser Leu 
    2675                 2680                 2685             


Pro Glu  Glu Ala Arg Thr Ala  Ile His Ser Leu Thr  Glu Arg Leu 
    2690                 2695                 2700             


Tyr Val  Gly Gly Pro Met Phe  Asn Ser Lys Gly Gln  Thr Cys Gly 
    2705                 2710                 2715             


Tyr Arg  Arg Cys Arg Ala Ser  Gly Val Leu Thr Thr  Ser Met Gly 
    2720                 2725                 2730             


Asn Thr  Ile Thr Cys Tyr Val  Lys Ala Leu Ala Ala  Cys Lys Ala 
    2735                 2740                 2745             


Ala Gly  Ile Val Ala Pro Thr  Met Leu Val Cys Gly  Asp Asp Leu 
    2750                 2755                 2760             


Val Val  Ile Ser Glu Ser Gln  Gly Thr Glu Glu Asp  Glu Arg Asn 
    2765                 2770                 2775             


Leu Arg  Ala Phe Thr Glu Ala  Met Thr Arg Tyr Ser  Ala Pro Pro 
    2780                 2785                 2790             


Gly Asp  Pro Pro Arg Pro Glu  Tyr Asp Leu Glu Leu  Ile Thr Ser 
    2795                 2800                 2805             


Cys Ser  Ser Asn Val Ser Val  Ala Leu Gly Pro Gln  Gly Arg Arg 
    2810                 2815                 2820             


Arg Tyr  Tyr Leu Thr Arg Asp  Pro Thr Thr Pro Ile  Ala Arg Ala 
    2825                 2830                 2835             


Ala Trp  Glu Thr Val Arg His  Ser Pro Val Asn Ser  Trp Leu Gly 
    2840                 2845                 2850             


Asn Ile  Ile Gln Tyr Ala Pro  Thr Ile Trp Val Arg  Met Val Leu 
    2855                 2860                 2865             


Met Thr  His Phe Phe Ser Ile  Leu Met Ala Gln Asp  Thr Leu Asp 
    2870                 2875                 2880             


Gln Asn  Leu Asn Phe Glu Met  Tyr Gly Ser Val Tyr  Ser Val Ser 
    2885                 2890                 2895             


Pro Leu  Asp Leu Pro Ala Ile  Ile Glu Arg Leu His  Gly Leu Asp 
    2900                 2905                 2910             


Ala Phe  Ser Leu His Thr Tyr  Thr Pro His Glu Leu  Thr Arg Val 
    2915                 2920                 2925             


Ala Ser  Ala Leu Arg Lys Leu  Gly Ala Pro Pro Leu  Arg Ala Trp 
    2930                 2935                 2940             


Lys Ser  Arg Ala Arg Ala Val  Arg Ala Ser Leu Ile  Ser Arg Gly 
    2945                 2950                 2955             


Gly Arg  Ala Ala Val Cys Gly  Arg Tyr Leu Phe Asn  Trp Ala Val 
    2960                 2965                 2970             


Lys Thr  Lys Leu Lys Leu Thr  Pro Leu Pro Glu Ala  Arg Leu Leu 
    2975                 2980                 2985             


Asp Leu  Ser Ser Trp Phe Thr  Val Gly Ala Gly Gly  Gly Asp Ile 
    2990                 2995                 3000             


Tyr His  Ser Val Ser Arg Ala  Arg Pro Arg Leu Leu  Leu Leu Ser 
    3005                 3010                 3015             


Leu Leu  Leu Leu Xaa Val Gly  Val Gly Leu Phe Leu  Leu Pro Ala 
    3020                 3025                 3030             


Arg 
    


<210>  100
<211>  3033
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic Sequence

<400>  100

Met Ser Thr Asn Pro Lys Pro Gln Arg Lys Thr Lys Arg Asn Thr Asn 
1               5                   10                  15      


Arg Arg Pro Gln Asp Val Lys Phe Pro Gly Gly Gly Gln Ile Val Gly 
            20                  25                  30          


Gly Val Tyr Leu Leu Pro Arg Arg Gly Pro Arg Leu Gly Val Arg Ala 
        35                  40                  45              


Thr Arg Lys Thr Ser Glu Arg Ser Gln Pro Arg Gly Arg Arg Gln Pro 
    50                  55                  60                  


Ile Pro Lys Asp Arg Arg Ser Thr Gly Lys Ser Trp Gly Lys Pro Gly 
65                  70                  75                  80  


Tyr Pro Trp Pro Leu Tyr Gly Asn Glu Gly Cys Gly Trp Ala Gly Trp 
                85                  90                  95      


Leu Leu Ser Pro Arg Gly Ser Arg Pro Thr Trp Gly Pro Thr Asp Pro 
            100                 105                 110         


Arg His Arg Ser Arg Asn Leu Gly Lys Val Ile Asp Thr Ile Thr Cys 
        115                 120                 125             


Gly Phe Ala Asp Leu Met Gly Tyr Ile Pro Val Val Gly Ala Pro Val 
    130                 135                 140                 


Gly Gly Val Ala Arg Ala Leu Ala His Gly Val Arg Val Leu Glu Asp 
145                 150                 155                 160 


Gly Ile Asn Tyr Ala Thr Gly Asn Leu Pro Gly Cys Ser Phe Ser Ile 
                165                 170                 175     


Phe Leu Leu Ala Leu Leu Ser Cys Val Thr Val Pro Val Ser Ala Val 
            180                 185                 190         


Glu Val Arg Asn Ile Ser Ser Ser Tyr Tyr Ala Thr Asn Asp Cys Ser 
        195                 200                 205             


Asn Asn Ser Ile Thr Trp Gln Leu Thr Asn Ala Val Leu His Leu Pro 
    210                 215                 220                 


Gly Cys Val Pro Cys Glu Asn Asp Asn Gly Thr Leu Arg Cys Trp Ile 
225                 230                 235                 240 


Gln Val Thr Pro Asn Val Ala Val Lys His Arg Gly Ala Leu Thr His 
                245                 250                 255     


Asn Leu Arg Thr His Val Asp Met Ile Val Met Ala Ala Thr Val Cys 
            260                 265                 270         


Ser Ala Leu Tyr Val Gly Asp Val Cys Gly Ala Val Met Ile Val Ser 
        275                 280                 285             


Gln Ala Leu Ile Val Ser Pro Glu Arg His Asn Phe Thr Gln Glu Cys 
    290                 295                 300                 


Asn Cys Ser Ile Tyr Gln Gly His Ile Thr Gly His Arg Met Ala Trp 
305                 310                 315                 320 


Asp Met Met Leu Asn Trp Ser Pro Thr Leu Thr Met Ile Leu Ala Tyr 
                325                 330                 335     


Ala Ala Arg Val Pro Glu Leu Val Leu Glu Val Val Phe Gly Gly His 
            340                 345                 350         


Trp Gly Val Val Phe Gly Leu Ala Tyr Phe Ser Met Gln Gly Ala Trp 
        355                 360                 365             


Ala Lys Val Ile Ala Ile Leu Leu Leu Val Ala Gly Val Asp Ala Thr 
    370                 375                 380                 


Thr Tyr Ser Ser Gly Ala Gln Ala Gly Arg Thr Thr Ser Gly Phe Ala 
385                 390                 395                 400 


Gly Leu Phe Ser Pro Gly Pro Lys Gln Asn Ile Gln Leu Ile Asn Thr 
                405                 410                 415     


Asn Gly Ser Trp His Ile Asn Arg Thr Ala Leu Asn Cys Asn Asp Ser 
            420                 425                 430         


Leu Gln Thr Gly Phe Ile Ala Ser Leu Phe Tyr Thr Asn Asn Phe Asn 
        435                 440                 445             


Ser Ser Gly Cys Pro Glu Arg Leu Ser Ser Cys Arg Gly Leu Asp Asp 
    450                 455                 460                 


Phe Arg Ile Gly Trp Gly Thr Leu Glu Tyr Glu Thr Asn Val Thr Asn 
465                 470                 475                 480 


Asp Glu Asp Met Arg Pro Tyr Cys Trp His Tyr Pro Pro Lys Pro Cys 
                485                 490                 495     


Gly Ile Val Ser Ala Arg Thr Val Cys Gly Pro Val Tyr Cys Phe Thr 
            500                 505                 510         


Pro Ser Pro Val Val Val Gly Thr Thr Asp Arg Gln Gly Val Pro Thr 
        515                 520                 525             


Tyr Ser Trp Gly Glu Asn Glu Thr Asp Val Phe Leu Leu Asn Ser Thr 
    530                 535                 540                 


Arg Pro Pro Gln Gly Ala Trp Phe Gly Cys Thr Trp Met Asn Gly Thr 
545                 550                 555                 560 


Gly Phe Thr Lys Thr Cys Gly Ala Pro Pro Cys Arg Ile Arg Arg Asp 
                565                 570                 575     


Tyr Asn Ser Thr Leu Asp Leu Leu Cys Pro Thr Asp Cys Phe Arg Lys 
            580                 585                 590         


His Pro Asp Ala Thr Tyr Leu Lys Cys Gly Ala Gly Pro Trp Leu Thr 
        595                 600                 605             


Pro Arg Cys Leu Val Asp Tyr Pro Tyr Arg Leu Trp His Tyr Pro Cys 
    610                 615                 620                 


Thr Val Asn Phe Thr Ile Phe Lys Val Arg Met Tyr Val Gly Gly Val 
625                 630                 635                 640 


Glu His Arg Leu Ser Ala Ala Cys Asn Phe Thr Arg Gly Asp Arg Cys 
                645                 650                 655     


Arg Leu Glu Asp Arg Asp Arg Gly Gln Gln Ser Pro Leu Leu His Ser 
            660                 665                 670         


Thr Thr Glu Trp Ala Val Leu Pro Cys Ser Phe Ser Asp Leu Pro Ala 
        675                 680                 685             


Leu Ser Thr Gly Leu Leu His Leu His Gln Asn Ile Val Asp Val Gln 
    690                 695                 700                 


Tyr Leu Tyr Gly Leu Ser Pro Ala Ile Thr Arg Tyr Ile Val Lys Trp 
705                 710                 715                 720 


Glu Trp Val Val Leu Leu Phe Leu Leu Leu Ala Asp Ala Arg Val Cys 
                725                 730                 735     


Ala Cys Leu Trp Met Leu Ile Ile Leu Gly Gln Ala Glu Ala Ala Leu 
            740                 745                 750         


Glu Lys Leu Ile Ile Leu His Ser Ala Ser Ala Ala Ser Ala Asn Gly 
        755                 760                 765             


Pro Leu Trp Phe Phe Ile Phe Phe Thr Ala Ala Trp Tyr Leu Lys Gly 
    770                 775                 780                 


Arg Val Val Pro Val Ala Thr Tyr Ser Val Leu Gly Leu Trp Ser Phe 
785                 790                 795                 800 


Leu Leu Leu Val Leu Ala Leu Pro Gln Gln Ala Tyr Ala Leu Asp Ala 
                805                 810                 815     


Ala Glu Gln Gly Glu Leu Gly Leu Val Ile Leu Val Ile Ile Ser Ile 
            820                 825                 830         


Phe Thr Leu Thr Pro Ala Tyr Lys Ile Leu Leu Ser Arg Ser Val Trp 
        835                 840                 845             


Trp Leu Ser Tyr Met Leu Val Leu Ala Glu Ala Gln Ile Gln Gln Trp 
    850                 855                 860                 


Val Pro Pro Leu Glu Ala Arg Gly Gly Arg Asp Gly Ile Ile Trp Val 
865                 870                 875                 880 


Ala Val Ile Leu His Pro Arg Leu Val Phe Glu Val Thr Lys Trp Leu 
                885                 890                 895     


Leu Ala Ile Leu Gly Pro Ala Tyr Leu Leu Lys Ala Ser Leu Leu Arg 
            900                 905                 910         


Val Pro Tyr Phe Val Arg Ala His Ala Leu Leu Arg Val Cys Thr Leu 
        915                 920                 925             


Val Arg His Leu Ala Gly Ala Arg Tyr Ile Gln Met Leu Leu Ile Thr 
    930                 935                 940                 


Ile Gly Arg Trp Thr Gly Thr Tyr Ile Tyr Asp His Leu Ser Pro Leu 
945                 950                 955                 960 


Ser Thr Trp Ala Ala Gln Gly Leu Arg Asp Leu Ala Val Ala Val Glu 
                965                 970                 975     


Pro Val Val Phe Ser Pro Met Glu Lys Lys Val Ile Val Trp Gly Ala 
            980                 985                 990         


Glu Thr Val Ala Cys Gly Asp Ile  Leu His Gly Leu Pro  Val Ser Ala 
        995                 1000                 1005             


Arg Leu  Gly Arg Glu Val Leu  Leu Gly Pro Ala Asp  Ser Tyr Thr 
    1010                 1015                 1020             


Ser Lys  Gly Trp Lys Leu Leu  Ala Pro Ile Thr Ala  Tyr Thr Gln 
    1025                 1030                 1035             


Gln Thr  Arg Gly Leu Leu Gly  Ala Ile Val Val Ser  Leu Thr Gly 
    1040                 1045                 1050             


Arg Asp  Lys Asn Glu Gln Ala  Gly Gln Val Gln Val  Leu Ser Ser 
    1055                 1060                 1065             


Val Thr  Gln Ser Phe Leu Gly  Thr Ser Ile Ser Gly  Val Leu Trp 
    1070                 1075                 1080             


Thr Val  Tyr His Gly Ala Gly  Asn Lys Thr Leu Ala  Gly Pro Lys 
    1085                 1090                 1095             


Gly Pro  Val Thr Gln Met Tyr  Thr Ser Ala Glu Gly  Asp Leu Val 
    1100                 1105                 1110             


Gly Trp  Pro Ser Pro Pro Gly  Thr Lys Ser Leu Asp  Pro Cys Thr 
    1115                 1120                 1125             


Cys Gly  Ala Val Asp Leu Tyr  Leu Val Thr Arg Asn  Ala Asp Val 
    1130                 1135                 1140             


Ile Pro  Val Arg Arg Lys Asp  Asp Arg Arg Gly Ala  Leu Leu Ser 
    1145                 1150                 1155             


Pro Arg  Pro Leu Ser Thr Leu  Lys Gly Ser Ser Gly  Gly Pro Val 
    1160                 1165                 1170             


Leu Cys  Pro Arg Gly His Ala  Val Gly Leu Phe Arg  Ala Ala Val 
    1175                 1180                 1185             


Cys Ala  Arg Gly Val Ala Lys  Ser Ile Asp Phe Ile  Pro Val Glu 
    1190                 1195                 1200             


Ser Leu  Asp Ile Ala Thr Arg  Thr Pro Ser Phe Ser  Asp Asn Ser 
    1205                 1210                 1215             


Thr Pro  Pro Ala Val Pro Gln  Ser Tyr Gln Val Gly  Tyr Leu His 
    1220                 1225                 1230             


Ala Pro  Thr Gly Ser Gly Lys  Ser Thr Lys Val Pro  Ala Ala Tyr 
    1235                 1240                 1245             


Ala Ser  Gln Gly Tyr Lys Val  Leu Val Leu Asn Pro  Ser Val Ala 
    1250                 1255                 1260             


Ala Thr  Leu Gly Phe Gly Ala  Tyr Met Ser Lys Ala  His Gly Ile 
    1265                 1270                 1275             


Asn Pro  Asn Ile Arg Thr Gly  Val Arg Thr Val Thr  Thr Gly Asp 
    1280                 1285                 1290             


Pro Ile  Thr Tyr Ser Thr Tyr  Gly Lys Phe Leu Ala  Asp Gly Gly 
    1295                 1300                 1305             


Cys Ser  Ala Gly Ala Tyr Asp  Val Ile Ile Cys Asp  Glu Cys His 
    1310                 1315                 1320             


Ser Val  Asp Ala Thr Thr Ile  Leu Gly Ile Gly Thr  Val Leu Asp 
    1325                 1330                 1335             


Gln Ala  Glu Thr Ala Gly Ala  Arg Leu Val Val Leu  Ala Thr Ala 
    1340                 1345                 1350             


Thr Pro  Pro Gly Thr Val Thr  Thr Pro His Ser Asn  Ile Glu Glu 
    1355                 1360                 1365             


Val Ala  Leu Gly His Glu Gly  Glu Ile Pro Phe Tyr  Gly Lys Ala 
    1370                 1375                 1380             


Ile Pro  Leu Ala Phe Ile Lys  Gly Gly Arg His Leu  Ile Phe Cys 
    1385                 1390                 1395             


His Ser  Lys Lys Lys Cys Asp  Glu Leu Ala Ala Ala  Leu Arg Gly 
    1400                 1405                 1410             


Met Gly  Val Asn Ala Val Ala  Tyr Tyr Arg Gly Leu  Asp Val Ser 
    1415                 1420                 1425             


Val Ile  Pro Thr Gln Gly Asp  Val Val Val Val Ala  Thr Asp Ala 
    1430                 1435                 1440             


Leu Met  Thr Gly Tyr Thr Gly  Asp Phe Asp Ser Val  Ile Asp Cys 
    1445                 1450                 1455             


Asn Val  Ala Val Thr Gln Ile  Val Asp Phe Ser Leu  Asp Pro Thr 
    1460                 1465                 1470             


Phe Thr  Ile Thr Thr Gln Thr  Val Pro Gln Asp Ala  Val Ser Arg 
    1475                 1480                 1485             


Ser Gln  Arg Arg Gly Arg Thr  Gly Arg Gly Arg Leu  Gly Ile Tyr 
    1490                 1495                 1500             


Arg Tyr  Val Ser Ser Gly Glu  Arg Pro Ser Gly Met  Phe Asp Ser 
    1505                 1510                 1515             


Val Val  Leu Cys Glu Cys Tyr  Asp Ala Gly Ala Ala  Trp Tyr Glu 
    1520                 1525                 1530             


Leu Thr  Pro Ala Glu Thr Thr  Val Arg Leu Arg Ala  Tyr Phe Asn 
    1535                 1540                 1545             


Thr Pro  Gly Leu Pro Val Cys  Gln Asp His Leu Glu  Phe Trp Glu 
    1550                 1555                 1560             


Ala Val  Phe Thr Gly Leu Thr  His Ile Asp Ala His  Phe Leu Ser 
    1565                 1570                 1575             


Gln Thr  Lys Gln Gly Gly Asp  Asn Phe Ala Tyr Leu  Thr Ala Tyr 
    1580                 1585                 1590             


Gln Ala  Thr Val Cys Ala Arg  Ala Lys Ala Pro Pro  Pro Ser Trp 
    1595                 1600                 1605             


Asp Val  Met Trp Lys Cys Leu  Thr Arg Leu Lys Pro  Thr Leu Thr 
    1610                 1615                 1620             


Gly Pro  Thr Pro Leu Leu Tyr  Arg Leu Gly Ala Val  Thr Asn Glu 
    1625                 1630                 1635             


Val Thr  Leu Thr His Pro Val  Thr Lys Tyr Ile Ala  Thr Cys Met 
    1640                 1645                 1650             


Gln Ala  Asp Leu Glu Ile Met  Thr Ser Thr Trp Val  Leu Ala Gly 
    1655                 1660                 1665             


Gly Val  Leu Ala Ala Val Ala  Ala Tyr Cys Leu Ala  Thr Gly Cys 
    1670                 1675                 1680             


Ile Ser  Ile Ile Gly Arg Leu  His Leu Asn Asp Gln  Val Val Val 
    1685                 1690                 1695             


Ala Pro  Asp Lys Glu Ile Leu  Tyr Glu Ala Phe Asp  Glu Met Glu 
    1700                 1705                 1710             


Glu Cys  Ala Ser Lys Ala Ala  Leu Ile Glu Glu Gly  Gln Arg Met 
    1715                 1720                 1725             


Ala Glu  Met Leu Lys Ser Lys  Ile Gln Gly Leu Leu  Gln Gln Ala 
    1730                 1735                 1740             


Thr Arg  Gln Ala Gln Asp Ile  Gln Pro Ala Ile Gln  Ser Ser Trp 
    1745                 1750                 1755             


Pro Lys  Leu Glu Gln Phe Trp  Ala Lys His Met Trp  Asn Phe Ile 
    1760                 1765                 1770             


Ser Gly  Ile Gln Tyr Leu Ala  Gly Leu Ser Thr Leu  Pro Gly Asn 
    1775                 1780                 1785             


Pro Ala  Val Ala Ser Met Met  Ala Phe Ser Ala Ala  Leu Thr Ser 
    1790                 1795                 1800             


Pro Leu  Pro Thr Ser Thr Thr  Ile Leu Leu Asn Ile  Met Gly Gly 
    1805                 1810                 1815             


Trp Leu  Ala Ser Gln Ile Ala  Pro Pro Ala Gly Ala  Thr Gly Phe 
    1820                 1825                 1830             


Val Val  Ser Gly Leu Val Gly  Ala Ala Val Gly Ser  Ile Gly Leu 
    1835                 1840                 1845             


Gly Lys  Ile Leu Val Asp Val  Leu Ala Gly Tyr Gly  Ala Gly Ile 
    1850                 1855                 1860             


Ser Gly  Ala Leu Val Ala Phe  Lys Ile Met Ser Gly  Glu Lys Pro 
    1865                 1870                 1875             


Ser Val  Glu Asp Val Val Asn  Leu Leu Pro Ala Ile  Leu Ser Pro 
    1880                 1885                 1890             


Gly Ala  Leu Val Val Gly Val  Ile Cys Ala Ala Ile  Leu Arg Arg 
    1895                 1900                 1905             


His Val  Gly Gln Gly Glu Gly  Ala Val Gln Trp Met  Asn Arg Leu 
    1910                 1915                 1920             


Ile Ala  Phe Ala Ser Arg Gly  Asn His Val Ala Pro  Thr His Tyr 
    1925                 1930                 1935             


Val Ala  Glu Ser Asp Ala Ser  Gln Arg Val Thr Gln  Val Leu Ser 
    1940                 1945                 1950             


Ser Leu  Thr Ile Thr Ser Leu  Leu Arg Arg Leu His  Ala Trp Ile 
    1955                 1960                 1965             


Thr Glu  Asp Cys Pro Val Pro  Cys Ser Gly Ser Trp  Leu Arg Asp 
    1970                 1975                 1980             


Ile Trp  Asp Trp Val Cys Ser  Ile Leu Thr Asp Phe  Lys Asn Trp 
    1985                 1990                 1995             


Leu Ser  Ser Lys Leu Leu Pro  Lys Met Pro Gly Leu  Pro Phe Ile 
    2000                 2005                 2010             


Ser Cys  Gln Lys Gly Tyr Arg  Gly Val Trp Ala Gly  Thr Gly Val 
    2015                 2020                 2025             


Met Thr  Thr Arg Cys Pro Cys  Gly Ala Asn Ile Ser  Gly His Val 
    2030                 2035                 2040             


Arg Met  Gly Thr Met Lys Ile  Thr Gly Pro Lys Thr  Cys Leu Asn 
    2045                 2050                 2055             


Leu Trp  Gln Gly Thr Phe Pro  Ile Asn Cys Tyr Thr  Glu Gly Pro 
    2060                 2065                 2070             


Cys Val  Pro Lys Pro Pro Pro  Asn Tyr Lys Thr Ala  Ile Trp Arg 
    2075                 2080                 2085             


Val Ala  Ala Ser Glu Tyr Val  Glu Val Thr Gln His  Gly Ser Phe 
    2090                 2095                 2100             


Ser Tyr  Val Thr Gly Leu Thr  Ser Asp Asn Leu Lys  Val Pro Cys 
    2105                 2110                 2115             


Gln Val  Pro Ala Pro Glu Phe  Phe Ser Trp Val Asp  Gly Val Gln 
    2120                 2125                 2130             


Ile His  Arg Phe Ala Pro Thr  Pro Gly Pro Phe Phe  Arg Asp Glu 
    2135                 2140                 2145             


Val Thr  Phe Thr Val Gly Leu  Asn Ser Phe Val Val  Gly Ser Gln 
    2150                 2155                 2160             


Leu Pro  Cys Asp Pro Glu Pro  Asp Thr Glu Val Leu  Ala Ser Met 
    2165                 2170                 2175             


Leu Thr  Asp Pro Ser His Ile  Thr Ala Glu Ala Ala  Ala Arg Arg 
    2180                 2185                 2190             


Leu Ala  Arg Gly Ser Pro Pro  Ser Gln Ala Ser Ser  Ser Ala Ser 
    2195                 2200                 2205             


Gln Leu  Ser Ala Pro Ser Leu  Lys Ala Thr Cys Thr  Thr His Lys 
    2210                 2215                 2220             


Met Ala  Tyr Asp Cys Asp Met  Val Asp Ala Asn Leu  Phe Met Gly 
    2225                 2230                 2235             


Gly Asp  Val Thr Arg Ile Glu  Ser Asp Ser Lys Val  Ile Val Leu 
    2240                 2245                 2250             


Asp Ser  Leu Asp Ser Met Thr  Glu Val Glu Asp Asp  Arg Glu Pro 
    2255                 2260                 2265             


Ser Val  Pro Ser Glu Tyr Leu  Ile Arg Arg Arg Lys  Phe Pro Pro 
    2270                 2275                 2280             


Ala Leu  Pro Pro Trp Ala Arg  Pro Asp Tyr Asn Pro  Pro Val Ile 
    2285                 2290                 2295             


Glu Thr  Trp Lys Arg Pro Gly  Tyr Glu Pro Pro Thr  Val Leu Gly 
    2300                 2305                 2310             


Cys Ala  Leu Pro Pro Thr Pro  Gln Ala Pro Val Pro  Pro Pro Arg 
    2315                 2320                 2325             


Arg Arg  Arg Ala Lys Val Leu  Thr Gln Asp Asn Val  Glu Gly Val 
    2330                 2335                 2340             


Leu Arg  Glu Met Ala Asp Lys  Val Leu Ser Pro Leu  Gln Asp His 
    2345                 2350                 2355             


Asn Asp  Ser Gly His Ser Thr  Gly Ala Asp Thr Gly  Gly Asp Ser 
    2360                 2365                 2370             


Val Gln  Gln Pro Ser Asp Glu  Thr Ala Ala Ser Glu  Ala Gly Ser 
    2375                 2380                 2385             


Leu Ser  Ser Met Pro Pro Leu  Glu Gly Glu Pro Gly  Asp Pro Asp 
    2390                 2395                 2400             


Leu Glu  Phe Glu Pro Ala Gly  Ser Ala Pro Pro Ser  Glu Gly Glu 
    2405                 2410                 2415             


Cys Glu  Val Ile Asp Ser Asp  Ser Lys Ser Trp Ser  Thr Val Ser 
    2420                 2425                 2430             


Asp Gln  Glu Asp Ser Val Ile  Cys Cys Ser Met Ser  Tyr Ser Trp 
    2435                 2440                 2445             


Thr Gly  Ala Leu Ile Thr Pro  Cys Gly Pro Glu Glu  Glu Lys Leu 
    2450                 2455                 2460             


Pro Ile  Asn Pro Leu Ser Asn  Ser Leu Met Arg Phe  His Asn Lys 
    2465                 2470                 2475             


Val Tyr  Ser Thr Thr Ser Arg  Ser Ala Ser Leu Arg  Ala Lys Lys 
    2480                 2485                 2490             


Val Thr  Phe Asp Arg Val Gln  Val Leu Asp Ala His  Tyr Asp Ser 
    2495                 2500                 2505             


Val Leu  Gln Asp Val Lys Arg  Ala Ala Ser Lys Val  Ser Ala Arg 
    2510                 2515                 2520             


Leu Leu  Ser Val Glu Glu Ala  Cys Ala Leu Thr Pro  Pro His Ser 
    2525                 2530                 2535             


Ala Lys  Ser Arg Tyr Gly Phe  Gly Ala Lys Glu Val  Arg Ser Leu 
    2540                 2545                 2550             


Ser Arg  Arg Ala Val Asn His  Ile Arg Ser Val Trp  Glu Asp Leu 
    2555                 2560                 2565             


Leu Glu  Asp Gln His Thr Pro  Ile Asp Thr Thr Ile  Met Ala Lys 
    2570                 2575                 2580             


Asn Glu  Val Phe Cys Val Asp  Pro Thr Lys Gly Gly  Lys Lys Pro 
    2585                 2590                 2595             


Ala Arg  Leu Ile Val Tyr Pro  Asp Leu Gly Val Arg  Val Cys Glu 
    2600                 2605                 2610             


Lys Met  Ala Leu Tyr Asp Ile  Ala Gln Lys Leu Pro  Lys Ala Ile 
    2615                 2620                 2625             


Met Gly  Pro Ser Tyr Gly Phe  Gln Tyr Ser Pro Ala  Glu Arg Val 
    2630                 2635                 2640             


Asp Phe  Leu Leu Lys Ala Trp  Gly Ser Lys Lys Asp  Pro Met Gly 
    2645                 2650                 2655             


Phe Ser  Tyr Asp Thr Arg Cys  Phe Asp Ser Thr Val  Thr Glu Arg 
    2660                 2665                 2670             


Asp Ile  Arg Thr Glu Glu Ser  Ile Tyr Gln Ala Cys  Ser Leu Pro 
    2675                 2680                 2685             


Gln Glu  Ala Arg Thr Val Ile  His Ser Leu Thr Glu  Arg Leu Tyr 
    2690                 2695                 2700             


Val Gly  Gly Pro Met Thr Asn  Ser Lys Gly Gln Ser  Cys Gly Tyr 
    2705                 2710                 2715             


Arg Arg  Cys Arg Ala Ser Gly  Val Phe Thr Thr Ser  Met Gly Asn 
    2720                 2725                 2730             


Thr Met  Thr Cys Tyr Ile Lys  Ala Leu Ala Ala Cys  Lys Ala Ala 
    2735                 2740                 2745             


Gly Ile  Val Asp Pro Ile Met  Leu Val Cys Gly Asp  Asp Leu Val 
    2750                 2755                 2760             


Val Ile  Ser Glu Ser Gln Gly  Asn Glu Glu Asp Glu  Arg Asn Leu 
    2765                 2770                 2775             


Arg Ala  Phe Thr Glu Ala Met  Thr Arg Tyr Ser Ala  Pro Pro Gly 
    2780                 2785                 2790             


Asp Leu  Pro Arg Pro Glu Tyr  Asp Leu Glu Leu Ile  Thr Ser Cys 
    2795                 2800                 2805             


Ser Ser  Asn Val Ser Val Ala  Leu Asp Ser Arg Gly  Arg Arg Arg 
    2810                 2815                 2820             


Tyr Phe  Leu Thr Arg Asp Pro  Thr Thr Pro Ile Thr  Arg Ala Ala 
    2825                 2830                 2835             


Trp Glu  Thr Val Arg His Ser  Pro Val Asn Ser Trp  Leu Gly Asn 
    2840                 2845                 2850             


Ile Ile  Gln Tyr Ala Pro Thr  Ile Trp Val Arg Met  Val Ile Met 
    2855                 2860                 2865             


Thr His  Phe Phe Ser Ile Leu  Leu Ala Gln Asp Thr  Leu Asn Gln 
    2870                 2875                 2880             


Asn Leu  Asn Phe Glu Met Tyr  Gly Ala Val Tyr Ser  Val Asn Pro 
    2885                 2890                 2895             


Leu Asp  Leu Pro Ala Ile Ile  Glu Arg Leu His Gly  Leu Asp Ala 
    2900                 2905                 2910             


Phe Ser  Leu His Thr Tyr Ser  Pro His Glu Leu Ser  Arg Val Ala 
    2915                 2920                 2925             


Ala Thr  Leu Arg Lys Leu Gly  Ala Pro Pro Leu Arg  Ala Trp Lys 
    2930                 2935                 2940             


Ser Arg  Ala Arg Ala Val Arg  Ala Ser Leu Ile Ala  Gln Gly Gly 
    2945                 2950                 2955             


Arg Ala  Ala Ile Cys Gly Arg  Tyr Leu Phe Asn Trp  Ala Val Lys 
    2960                 2965                 2970             


Thr Lys  Leu Lys Leu Thr Pro  Leu Pro Glu Ala Ser  Arg Leu Asp 
    2975                 2980                 2985             


Leu Ser  Gly Trp Phe Thr Val  Gly Ala Gly Gly Gly  Asp Ile Phe 
    2990                 2995                 3000             


His Ser  Val Ser His Ala Arg  Pro Arg Leu Leu Leu  Leu Cys Leu 
    3005                 3010                 3015             


Leu Leu  Leu Ser Val Gly Val  Gly Ile Phe Leu Leu  Pro Ala Arg 
    3020                 3025                 3030             


<210>  101
<211>  3068
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic Sequence


<220>
<221>  misc_feature
<222>  (385)..(385)
<223>  Xaa can be any amino acid

<220>
<221>  misc_feature
<222>  (409)..(409)
<223>  Xaa can be any amino acid

<220>
<221>  misc_feature
<222>  (585)..(585)
<223>  Xaa can be any amino acid

<220>
<221>  misc_feature
<222>  (3048)..(3048)
<223>  Xaa can be any amino acid

<400>  101

Met Ser Thr Leu Pro Lys Pro Gln Arg Lys Thr Lys Arg Asn Thr Ile 
1               5                   10                  15      


Arg Arg Pro Gln Asp Val Lys Phe Pro Gly Gly Gly Gln Ile Val Gly 
            20                  25                  30          


Gly Val Tyr Val Leu Pro Arg Arg Gly Pro Arg Leu Gly Val Arg Ala 
        35                  40                  45              


Thr Arg Lys Thr Ser Glu Arg Ser Gln Pro Arg Gly Arg Arg Gln Pro 
    50                  55                  60                  


Ile Pro Lys Ala Arg Arg Ser Glu Gly Arg Ser Trp Ala Gln Pro Gly 
65                  70                  75                  80  


Tyr Pro Trp Pro Leu Tyr Gly Asn Glu Gly Cys Gly Trp Ala Gly Trp 
                85                  90                  95      


Leu Leu Ser Pro Arg Gly Ser Arg Pro Ser Trp Gly Pro Asn Asp Pro 
            100                 105                 110         


Arg Arg Arg Ser Arg Asn Leu Gly Lys Val Ile Asp Thr Leu Thr Cys 
        115                 120                 125             


Gly Phe Ala Asp Leu Met Gly Tyr Ile Pro Leu Val Gly Ala Pro Val 
    130                 135                 140                 


Gly Gly Val Ala Arg Ala Leu Ala His Gly Val Arg Ala Leu Glu Asp 
145                 150                 155                 160 


Gly Ile Asn Phe Ala Thr Gly Asn Leu Pro Gly Cys Ser Phe Ser Ile 
                165                 170                 175     


Phe Leu Leu Ala Leu Phe Ser Cys Leu Ile His Pro Ala Ala Ser Leu 
            180                 185                 190         


Glu Trp Arg Asn Thr Ser Gly Leu Tyr Val Leu Thr Asn Asp Cys Ser 
        195                 200                 205             


Asn Ser Ser Ile Val Tyr Glu Ala Asp Asp Val Ile Leu His Thr Pro 
    210                 215                 220                 


Gly Cys Ile Pro Cys Val Gln Thr Asp Gly Asn Thr Ser Thr Cys Trp 
225                 230                 235                 240 


Thr Pro Val Thr Pro Thr Val Ala Val Lys Tyr Val Gly Ala Thr Thr 
                245                 250                 255     


Ala Ser Ile Arg Ser His Val Asp Leu Leu Val Gly Ala Ala Thr Met 
            260                 265                 270         


Cys Ser Ala Leu Tyr Val Gly Asp Met Cys Gly Ala Val Phe Leu Val 
        275                 280                 285             


Gly Gln Ala Phe Thr Phe Arg Pro Arg Arg His Gln Thr Val Gln Thr 
    290                 295                 300                 


Cys Asn Cys Ser Leu Tyr Pro Gly His Leu Ser Gly His Arg Met Ala 
305                 310                 315                 320 


Trp Asp Met Met Met Asn Trp Ser Pro Ala Val Gly Met Val Val Ala 
                325                 330                 335     


His Val Leu Arg Leu Pro Gln Thr Leu Phe Asp Ile Ile Ala Gly Ala 
            340                 345                 350         


His Trp Gly Ile Leu Ala Gly Leu Ala Tyr Tyr Ser Met Gln Gly Asn 
        355                 360                 365             


Trp Ala Lys Val Ala Ile Ile Met Val Met Phe Ser Gly Val Asp Ala 
    370                 375                 380                 


Xaa Thr His Thr Thr Gly Gly Ser Ala Ala Arg Gly Ala Arg Gly Leu 
385                 390                 395                 400 


Thr Ser Leu Phe Ser Val Gly Pro Xaa Gln Asn Leu Gln Leu Val Asn 
                405                 410                 415     


Thr Asn Gly Ser Trp His Ile Asn Arg Thr Ala Leu Asn Cys Asn Asp 
            420                 425                 430         


Ser Ile Asn Thr Gly Phe Ile Ala Gly Leu Phe Tyr Tyr His Lys Phe 
        435                 440                 445             


Asn Ser Thr Gly Cys Pro Gln Arg Leu Ser Ser Cys Lys Pro Ile Thr 
    450                 455                 460                 


Phe Phe Arg Gln Gly Trp Gly Pro Leu Thr Asp Ala Asn Asn Ile Thr 
465                 470                 475                 480 


Gly Pro Ser Asp Asp Lys Pro Tyr Cys Trp His Tyr Ala Pro Arg Pro 
                485                 490                 495     


Cys Asp Val Val Pro Ala Ser Ser Val Cys Gly Pro Val Tyr Cys Phe 
            500                 505                 510         


Thr Pro His His Ser Pro Val Val Val Gly Thr Thr Asp Ala Lys Gly 
        515                 520                 525             


Val Pro Thr Tyr Thr Trp Gly Glu Asn Glu Thr Asp Val Phe Leu Leu 
    530                 535                 540                 


Glu Ser Leu Arg Pro Pro Ser Gly Arg Trp Phe Gly Cys Thr Trp Met 
545                 550                 555                 560 


Asn Ser Thr Arg Gly Phe Val Lys Thr Cys Gly Ala Pro Pro Cys Asn 
                565                 570                 575     


Ile Tyr Gly Gly Gly Gly Asn Pro Xaa Asn Asn Glu Ser Asp Leu Phe 
            580                 585                 590         


Cys Pro Thr Asp Cys Phe Arg Lys His Pro Glu Ala Thr Tyr Ser Arg 
        595                 600                 605             


Cys Gly Ala Gly Pro Trp Leu Thr Pro Arg Cys Met Val Asp Tyr Pro 
    610                 615                 620                 


Tyr Arg Leu Trp His Tyr Pro Cys Thr Val Asn Phe Thr Leu Phe Lys 
625                 630                 635                 640 


Val Arg Met Phe Val Gly Gly Phe Glu His Arg Phe Thr Ala Ala Cys 
                645                 650                 655     


Asn Trp Thr Arg Gly Glu Arg Cys Asp Ile Glu Asp Arg Asp Arg Ser 
            660                 665                 670         


Glu Gln His Pro Leu Leu His Ser Thr Thr Glu Leu Ala Ile Leu Pro 
        675                 680                 685             


Cys Ser Phe Thr Pro Met Pro Ala Leu Ser Thr Gly Leu Ile His Leu 
    690                 695                 700                 


His Gln Asn Ile Val Asp Val Gln Tyr Leu Tyr Gly Val Gly Ser Gly 
705                 710                 715                 720 


Met Val Gly Trp Ala Leu Lys Trp Glu Phe Val Ile Leu Val Phe Leu 
                725                 730                 735     


Leu Leu Ala Asp Ala Arg Val Cys Val Ala Leu Trp Leu Met Leu Met 
            740                 745                 750         


Ile Ser Gln Ala Glu Ala Ala Leu Glu Asn Leu Val Thr Leu Asn Ala 
        755                 760                 765             


Val Ala Ala Ala Gly Thr His Gly Ile Gly Trp Tyr Leu Val Ala Phe 
    770                 775                 780                 


Cys Ala Ala Trp His Val Arg Arg Ala Gly Lys Leu Val Pro Leu Val 
785                 790                 795                 800 


Thr Tyr Ser Leu Thr Gly Leu Trp Ser Leu Ala Leu Leu Val Leu Leu 
                805                 810                 815     


Leu Pro Gln Arg Ala Tyr Ala Trp Ser Gly Glu Asp Ser Ala Thr Leu 
            820                 825                 830         


Gly Ala Gly Ile Leu Val Leu Phe Gly Phe Phe Thr Leu Ser Pro Trp 
        835                 840                 845             


Tyr Lys His Trp Ile Gly Arg Leu Met Trp Trp Asn Gln Tyr Thr Ile 
    850                 855                 860                 


Cys Arg Cys Glu Ala Ala Leu Gln Val Trp Val Pro Pro Leu Leu Ala 
865                 870                 875                 880 


Arg Gly Ser Arg Asp Gly Val Ile Leu Leu Thr Ser Leu Leu Tyr Pro 
                885                 890                 895     


Ser Leu Ile Phe Asp Ile Thr Lys Leu Leu Ile Ala Val Leu Gly Pro 
            900                 905                 910         


Leu Tyr Leu Ile Gln Ala Ala Ile Thr Thr Thr Pro Tyr Phe Val Arg 
        915                 920                 925             


Ala His Val Leu Val Arg Leu Cys Met Leu Val Arg Ser Val Met Gly 
    930                 935                 940                 


Gly Lys Tyr Phe Gln Met Ile Ile Leu Ser Ile Gly Arg Trp Phe Asn 
945                 950                 955                 960 


Thr Tyr Leu Tyr Asp His Leu Ala Pro Met Gln His Trp Ala Ala Ala 
                965                 970                 975     


Gly Leu Lys Asp Leu Ala Val Ala Thr Glu Pro Val Ile Phe Ser Pro 
            980                 985                 990         


Met Glu Ile Lys Val Ile Thr Trp  Gly Ala Asp Thr Ala  Ala Cys Gly 
        995                 1000                 1005             


Asp Ile  Leu Cys Gly Leu Pro  Val Ser Ala Arg Leu  Gly Arg Glu 
    1010                 1015                 1020             


Val Leu  Leu Gly Pro Ala Asp  Asp Tyr Arg Glu Met  Gly Trp Arg 
    1025                 1030                 1035             


Leu Leu  Ala Pro Ile Thr Ala  Tyr Ala Gln Gln Thr  Arg Gly Leu 
    1040                 1045                 1050             


Leu Gly  Thr Ile Val Thr Ser  Leu Thr Gly Arg Asp  Lys Asn Val 
    1055                 1060                 1065             


Val Thr  Gly Glu Val Gln Val  Leu Ser Thr Ala Thr  Gln Thr Phe 
    1070                 1075                 1080             


Leu Gly  Thr Thr Val Gly Gly  Val Met Trp Thr Val  Tyr His Gly 
    1085                 1090                 1095             


Ala Gly  Ser Arg Thr Leu Ala  Gly Ala Lys His Pro  Ala Leu Gln 
    1100                 1105                 1110             


Met Tyr  Thr Asn Val Asp Gln  Asp Leu Val Gly Trp  Pro Ala Pro 
    1115                 1120                 1125             


Pro Gly  Ala Lys Ser Leu Glu  Pro Cys Ala Cys Gly  Ser Ala Asp 
    1130                 1135                 1140             


Leu Tyr  Leu Val Thr Arg Asp  Ala Asp Val Ile Pro  Ala Arg Arg 
    1145                 1150                 1155             


Arg Gly  Asp Ser Thr Ala Ser  Leu Leu Ser Pro Arg  Pro Leu Ala 
    1160                 1165                 1170             


Cys Leu  Lys Gly Ser Ser Gly  Gly Pro Val Met Cys  Pro Ser Gly 
    1175                 1180                 1185             


His Val  Ala Gly Ile Phe Arg  Ala Ala Val Cys Thr  Arg Gly Val 
    1190                 1195                 1200             


Ala Lys  Ala Leu Gln Phe Ile  Pro Val Glu Thr Leu  Ser Thr Gln 
    1205                 1210                 1215             


Ala Arg  Ser Pro Ser Phe Ser  Asp Asn Ser Thr Pro  Pro Ala Val 
    1220                 1225                 1230             


Pro Gln  Ser Tyr Gln Val Gly  Tyr Leu His Ala Pro  Thr Gly Ser 
    1235                 1240                 1245             


Gly Lys  Ser Thr Lys Val Pro  Ala Ala Tyr Val Ala  Gln Gly Tyr 
    1250                 1255                 1260             


Asn Val  Leu Val Leu Asn Pro  Ser Val Ala Ala Thr  Leu Gly Phe 
    1265                 1270                 1275             


Gly Ser  Phe Met Ser Arg Ala  Tyr Gly Ile Asp Pro  Asn Ile Arg 
    1280                 1285                 1290             


Thr Gly  Asn Arg Thr Val Thr  Thr Gly Ala Lys Leu  Thr Tyr Ser 
    1295                 1300                 1305             


Thr Tyr  Gly Lys Phe Leu Ala  Asp Gly Gly Cys Ser  Gly Gly Ala 
    1310                 1315                 1320             


Tyr Asp  Val Ile Ile Cys Asp  Glu Cys His Ala Gln  Asp Ala Thr 
    1325                 1330                 1335             


Ser Ile  Leu Gly Ile Gly Thr  Val Leu Asp Gln Ala  Glu Thr Ala 
    1340                 1345                 1350             


Gly Val  Arg Leu Thr Val Leu  Ala Thr Ala Thr Pro  Pro Gly Ser 
    1355                 1360                 1365             


Ile Thr  Val Pro His Ser Asn  Ile Glu Glu Val Ala  Leu Gly Ser 
    1370                 1375                 1380             


Glu Gly  Glu Ile Pro Phe Tyr  Gly Lys Ala Ile Pro  Ile Ala Gln 
    1385                 1390                 1395             


Leu Lys  Gly Gly Arg His Leu  Ile Phe Cys His Ser  Lys Lys Lys 
    1400                 1405                 1410             


Cys Asp  Glu Ile Ala Ser Lys  Leu Arg Gly Met Gly  Leu Asn Ala 
    1415                 1420                 1425             


Val Ala  Tyr Tyr Arg Gly Leu  Asp Val Ser Val Ile  Pro Thr Thr 
    1430                 1435                 1440             


Gly Asp  Val Val Val Cys Ala  Thr Asp Ala Leu Met  Thr Gly Phe 
    1445                 1450                 1455             


Thr Gly  Asp Phe Asp Ser Val  Ile Asp Cys Asn Val  Ala Val Glu 
    1460                 1465                 1470             


Gln Tyr  Val Asp Phe Ser Leu  Asp Pro Thr Phe Ser  Ile Glu Thr 
    1475                 1480                 1485             


Arg Thr  Ala Pro Gln Asp Ala  Val Ser Arg Ser Gln  Arg Arg Gly 
    1490                 1495                 1500             


Arg Thr  Gly Arg Gly Arg Leu  Gly Thr Tyr Arg Tyr  Val Thr Pro 
    1505                 1510                 1515             


Gly Glu  Arg Pro Ser Gly Met  Phe Asp Ser Val Val  Leu Cys Glu 
    1520                 1525                 1530             


Cys Tyr  Asp Ala Gly Cys Ser  Trp Tyr Asp Leu Gln  Pro Ala Glu 
    1535                 1540                 1545             


Thr Thr  Val Arg Leu Arg Ala  Tyr Leu Ser Thr Pro  Gly Leu Pro 
    1550                 1555                 1560             


Val Cys  Gln Asp His Leu Asp  Phe Trp Glu Ser Val  Phe Thr Gly 
    1565                 1570                 1575             


Leu Thr  His Ile Asp Ala His  Phe Leu Ser Gln Thr  Lys Gln Gln 
    1580                 1585                 1590             


Gly Leu  Asn Phe Ser Tyr Leu  Thr Ala Tyr Gln Ala  Thr Val Cys 
    1595                 1600                 1605             


Ala Arg  Ala Gln Ala Pro Pro  Pro Ser Trp Asp Glu  Thr Trp Lys 
    1610                 1615                 1620             


Cys Leu  Val Arg Leu Lys Pro  Thr Leu His Gly Pro  Thr Pro Leu 
    1625                 1630                 1635             


Leu Tyr  Arg Leu Gly Pro Val  Gln Asn Glu Ile Cys  Leu Thr His 
    1640                 1645                 1650             


Pro Ile  Thr Lys Tyr Ile Met  Ala Cys Met Ser Ala  Asp Leu Glu 
    1655                 1660                 1665             


Val Thr  Thr Ser Thr Trp Ser  Thr Trp Val Leu Leu  Gly Gly Val 
    1670                 1675                 1680             


Leu Ala  Ala Leu Ala Ala Tyr  Cys Leu Ser Val Gly  Cys Val Val 
    1685                 1690                 1695             


Ile Val  Gly His Ile Glu Leu  Gly Gly Lys Pro Ala  Leu Val Pro 
    1700                 1705                 1710             


Asp Lys  Glu Val Leu Tyr Gln  Gln Tyr Asp Glu Met  Glu Glu Cys 
    1715                 1720                 1725             


Ser Gln  Ala Ala Pro Tyr Ile  Glu Gln Ala Gln Val  Ile Ala His 
    1730                 1735                 1740             


Gln Phe  Lys Glu Lys Val Leu  Gly Leu Leu Gln Arg  Ala Thr Gln 
    1745                 1750                 1755             


Gln Gln  Ala Val Ile Glu Pro  Ile Val Ala Thr Asn  Trp Gln Lys 
    1760                 1765                 1770             


Leu Glu  Ala Phe Trp His Lys  His Met Trp Asn Phe  Val Ser Gly 
    1775                 1780                 1785             


Ile Gln  Tyr Leu Ala Gly Leu  Ser Thr Leu Pro Gly  Asn Pro Ala 
    1790                 1795                 1800             


Val Ala  Ser Leu Met Ala Phe  Thr Ala Ser Val Thr  Ser Pro Leu 
    1805                 1810                 1815             


Thr Thr  Asn Gln Thr Met Phe  Phe Asn Ile Leu Gly  Gly Trp Val 
    1820                 1825                 1830             


Ala Thr  His Leu Ala Gly Pro  Gln Ser Ser Ser Ala  Phe Val Val 
    1835                 1840                 1845             


Ser Gly  Leu Ala Gly Ala Ala  Ile Gly Gly Ile Gly  Leu Gly Arg 
    1850                 1855                 1860             


Val Leu  Leu Asp Ile Leu Ala  Gly Tyr Gly Ala Gly  Val Ser Gly 
    1865                 1870                 1875             


Ala Leu  Val Ala Phe Lys Ile  Met Gly Gly Glu Leu  Pro Thr Ala 
    1880                 1885                 1890             


Glu Asp  Met Val Asn Leu Leu  Pro Ala Ile Leu Ser  Pro Gly Ala 
    1895                 1900                 1905             


Leu Val  Val Gly Val Ile Cys  Ala Ala Ile Leu Arg  Arg His Val 
    1910                 1915                 1920             


Gly Pro  Gly Glu Gly Ala Val  Gln Trp Met Asn Arg  Leu Ile Ala 
    1925                 1930                 1935             


Phe Ala  Ser Arg Gly Asn His  Val Ser Pro Thr His  Tyr Val Pro 
    1940                 1945                 1950             


Glu Ser  Asp Ala Ala Ala Arg  Val Thr Ala Leu Leu  Ser Ser Leu 
    1955                 1960                 1965             


Thr Val  Thr Ser Leu Leu Arg  Arg Leu His Gln Trp  Ile Asn Glu 
    1970                 1975                 1980             


Asp Tyr  Pro Ser Pro Cys Ser  Gly Asp Trp Leu Arg  Thr Ile Trp 
    1985                 1990                 1995             


Asp Trp  Val Cys Thr Val Leu  Ser Asp Phe Lys Thr  Trp Leu Ser 
    2000                 2005                 2010             


Ala Lys  Ile Met Pro Ala Leu  Pro Gly Leu Pro Phe  Ile Ser Cys 
    2015                 2020                 2025             


Gln Lys  Gly Tyr Lys Gly Val  Trp Arg Gly Asp Gly  Val Met Ser 
    2030                 2035                 2040             


Thr Arg  Cys Pro Cys Gly Ala  Ser Ile Thr Gly His  Val Lys Asn 
    2045                 2050                 2055             


Gly Ser  Met Arg Leu Ala Gly  Pro Arg Thr Cys Ala  Asn Met Trp 
    2060                 2065                 2070             


His Gly  Thr Phe Pro Ile Asn  Glu Tyr Thr Thr Gly  Pro Ser Thr 
    2075                 2080                 2085             


Pro Cys  Pro Ser Pro Asn Tyr  Thr Arg Ala Leu Trp  Arg Val Ala 
    2090                 2095                 2100             


Ala Asn  Ser Tyr Val Glu Val  Arg Arg Val Gly Asp  Phe His Tyr 
    2105                 2110                 2115             


Ile Thr  Gly Ala Thr Glu Asp  Glu Leu Lys Cys Pro  Cys Gln Val 
    2120                 2125                 2130             


Pro Ala  Ala Glu Phe Phe Thr  Glu Val Asp Gly Val  Arg Leu His 
    2135                 2140                 2145             


Arg Tyr  Ala Pro Pro Cys Lys  Pro Leu Leu Arg Asp  Glu Ile Thr 
    2150                 2155                 2160             


Phe Met  Val Gly Leu Asn Ser  Tyr Ala Ile Gly Ser  Gln Leu Pro 
    2165                 2170                 2175             


Cys Glu  Pro Glu Pro Asp Val  Ser Val Leu Thr Ser  Met Leu Arg 
    2180                 2185                 2190             


Asp Pro  Ser His Ile Thr Ala  Glu Thr Ala Ala Arg  Arg Leu Ala 
    2195                 2200                 2205             


Arg Gly  Ser Pro Pro Ser Glu  Ala Ser Ser Ser Ala  Ser Gln Leu 
    2210                 2215                 2220             


Ser Ala  Pro Ser Leu Lys Ala  Thr Cys Gln Thr His  Arg Pro His 
    2225                 2230                 2235             


Pro Asp  Ala Glu Leu Val Asp  Ala Asn Leu Leu Trp  Arg Gln Glu 
    2240                 2245                 2250             


Met Gly  Ser Asn Ile Thr Arg  Val Glu Ser Glu Thr  Lys Val Val 
    2255                 2260                 2265             


Ile Leu  Asp Ser Phe Glu Pro  Leu Arg Ala Glu Thr  Asp Asp Ala 
    2270                 2275                 2280             


Glu Leu  Ser Val Ala Ala Glu  Cys Phe Lys Lys Pro  Pro Lys Tyr 
    2285                 2290                 2295             


Pro Pro  Ala Leu Pro Ile Trp  Ala Arg Pro Asp Tyr  Asn Pro Pro 
    2300                 2305                 2310             


Leu Leu  Asp Arg Trp Lys Ala  Pro Asp Tyr Val Pro  Pro Thr Val 
    2315                 2320                 2325             


His Gly  Cys Ala Leu Pro Pro  Arg Gly Ala Pro Pro  Val Pro Pro 
    2330                 2335                 2340             


Pro Arg  Arg Lys Arg Thr Ile  Gln Leu Asp Gly Ser  Asn Val Ser 
    2345                 2350                 2355             


Ala Ala  Leu Ala Ala Leu Ala  Glu Lys Ser Phe Pro  Ser Ser Lys 
    2360                 2365                 2370             


Pro Gln  Glu Glu Asn Ser Ser  Ser Ser Gly Val Asp  Thr Gln Ser 
    2375                 2380                 2385             


Ser Thr  Thr Ser Lys Val Pro  Pro Ser Pro Gly Gly  Glu Ser Asp 
    2390                 2395                 2400             


Ser Glu  Ser Cys Ser Ser Met  Pro Pro Leu Glu Gly  Glu Pro Gly 
    2405                 2410                 2415             


Asp Pro  Asp Leu Ser Cys Asp  Gln Val Glu Leu Gln  Pro Pro Pro 
    2420                 2425                 2430             


Gln Gly  Gly Gly Val Ala Pro  Gly Ser Gly Ser Gly  Ser Trp Ser 
    2435                 2440                 2445             


Thr Val  Ser Asp Ser Glu Glu  Gln Ser Val Val Cys  Cys Ser Met 
    2450                 2455                 2460             


Ser Tyr  Ser Trp Thr Gly Ala  Leu Ile Thr Pro Cys  Ser Ala Glu 
    2465                 2470                 2475             


Glu Glu  Lys Leu Pro Ile Ser  Pro Leu Ser Asn Ser  Leu Leu Arg 
    2480                 2485                 2490             


His His  Asn Leu Val Tyr Ser  Thr Ser Ser Arg Ser  Ala Ser Gln 
    2495                 2500                 2505             


Arg Gln  Lys Lys Val Thr Phe  Asp Arg Leu Gln Val  Leu Asp Asp 
    2510                 2515                 2520             


His Tyr  Lys Thr Ala Leu Lys  Glu Val Lys Glu Arg  Ala Ser Arg 
    2525                 2530                 2535             


Val Lys  Ala Arg Met Leu Thr  Ile Glu Glu Ala Cys  Ala Leu Val 
    2540                 2545                 2550             


Pro Pro  His Ser Ala Arg Ser  Lys Phe Gly Tyr Ser  Ala Lys Asp 
    2555                 2560                 2565             


Val Arg  Ser Leu Ser Ser Lys  Ala Ile Asn Gln Ile  Arg Ser Val 
    2570                 2575                 2580             


Trp Glu  Asp Leu Leu Glu Asp  Thr Thr Thr Pro Ile  Pro Thr Thr 
    2585                 2590                 2595             


Ile Met  Ala Lys Asn Glu Val  Phe Cys Val Asp Pro  Ala Lys Gly 
    2600                 2605                 2610             


Gly Arg  Lys Pro Ala Arg Leu  Ile Val Tyr Pro Asp  Leu Gly Val 
    2615                 2620                 2625             


Arg Val  Cys Glu Lys Arg Ala  Leu Tyr Asp Val Ile  Gln Lys Leu 
    2630                 2635                 2640             


Ser Ile  Glu Thr Met Gly Ser  Ala Tyr Gly Phe Gln  Tyr Ser Pro 
    2645                 2650                 2655             


Gln Gln  Arg Val Glu Arg Leu  Leu Lys Met Trp Thr  Ser Lys Lys 
    2660                 2665                 2670             


Thr Pro  Leu Gly Val Leu Phe  Ser Tyr Asp Thr Arg  Cys Phe Asp 
    2675                 2680                 2685             


Ser Thr  Val Thr Gly Glu Gln  Asp Ile Arg Val Glu  Glu Glu Ile 
    2690                 2695                 2700             


Tyr Gln  Cys Cys Asn Leu Glu  Pro Glu Ala Arg Lys  Val Ile Ser 
    2705                 2710                 2715             


Ser Leu  Thr Glu Arg Leu Tyr  Cys Gly Gly Pro Met  Phe Asn Ser 
    2720                 2725                 2730             


Lys Gly  Ala Gln Cys Gly Tyr  Arg Arg Cys Arg Ala  Ser Gly Val 
    2735                 2740                 2745             


Leu Pro  Thr Ser Phe Gly Asn  Thr Ile Thr Cys Tyr  Ile Lys Ala 
    2750                 2755                 2760             


Thr Ala  Ala Ala Arg Ala Ala  Gly Leu Arg Asn Pro  Asp Phe Leu 
    2765                 2770                 2775             


Val Cys  Gly Asp Asp Leu Val  Val Val Ala Glu Ser  Asp Gly Val 
    2780                 2785                 2790             


Asp Glu  Asp Arg Ala Ala Leu  Arg Ala Phe Thr Glu  Ala Met Thr 
    2795                 2800                 2805             


Arg Leu  Trp Thr Arg Tyr Tyr  Ser Ala Pro Pro Gly  Asp Ala Pro 
    2810                 2815                 2820             


His Arg  Pro Thr Leu Gln Pro  Thr Tyr Asp Leu Glu  Leu Ile Thr 
    2825                 2830                 2835             


Ser Cys  Ser Ser Asn Val Ser  Val Ala Arg Asp Asn  Lys Gly Lys 
    2840                 2845                 2850             


Arg Tyr  Tyr Tyr Leu Thr Arg  Asp Ala Thr Thr Pro  Leu Ala Arg 
    2855                 2860                 2865             


Ala Ala  Trp Glu Thr Ala Arg  His Thr Pro Gly Trp  Gly Val Asn 
    2870                 2875                 2880             


Ser Trp  Leu Gly Asn Ile Ile  Met Tyr Ala Pro Thr  Ile Trp Val 
    2885                 2890                 2895             


Arg Met  Val Met Met Thr His  Phe Phe Ser Ile Leu  Gln Ser Gln 
    2900                 2905                 2910             


Glu Ile  Leu Asp Arg Pro Leu  Asp Phe Glu Met Tyr  Gly Ala Thr 
    2915                 2920                 2925             


Tyr Ser  Val Thr Pro Leu Asp  Leu Pro Ala Ile Ile  Glu Arg Leu 
    2930                 2935                 2940             


His Gly  Leu Ser Ala Phe Thr  Leu His Ser Tyr Ser  Pro Val Glu 
    2945                 2950                 2955             


Leu Asn  Arg Val Ala Gly Thr  Leu Arg Lys Leu Gly  Cys Pro Pro 
    2960                 2965                 2970             


Leu Arg  Ala Trp Arg His Arg  Ala Arg Ala Val Arg  Ala Lys Leu 
    2975                 2980                 2985             


Ile Ala  Gln Gly Gly Lys Ala  Lys Ile Cys Gly Leu  Tyr Leu Phe 
    2990                 2995                 3000             


Asn Trp  Ala Val Arg Thr Lys  Thr Lys Leu Thr Pro  Leu Pro Ala 
    3005                 3010                 3015             


Ala Gly  Gln Leu Asp Leu Ser  Ser Trp Phe Thr Val  Gly Val Gly 
    3020                 3025                 3030             


Gly Asn  Asp Ile Tyr His Ser  Val Ser Arg Ala Arg  Thr Arg Xaa 
    3035                 3040                 3045             


Leu Leu  Leu Cys Leu Leu Leu  Leu Thr Val Gly Val  Gly Ile Phe 
    3050                 3055                 3060             


Leu Leu  Pro Ala Arg 
    3065             


<210>  102
<211>  3035
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic Sequence


<220>
<221>  misc_feature
<222>  (232)..(232)
<223>  Xaa can be any amino acid

<220>
<221>  misc_feature
<222>  (397)..(397)
<223>  Xaa can be any amino acid

<220>
<221>  misc_feature
<222>  (407)..(407)
<223>  Xaa can be any amino acid

<220>
<221>  misc_feature
<222>  (678)..(678)
<223>  Xaa can be any amino acid

<220>
<221>  misc_feature
<222>  (1002)..(1002)
<223>  Xaa can be any amino acid

<400>  102

Met Ser Thr Asn Pro Lys Pro Gln Arg Lys Thr Lys Arg Asn Thr Asn 
1               5                   10                  15      


Arg Arg Pro Met Asp Val Lys Phe Pro Gly Gly Gly Gln Ile Val Gly 
            20                  25                  30          


Gly Val Tyr Leu Leu Pro Arg Arg Gly Pro Arg Leu Gly Val Arg Ala 
        35                  40                  45              


Thr Arg Lys Thr Ser Glu Arg Ser Gln Pro Arg Gly Arg Arg Gln Pro 
    50                  55                  60                  


Ile Pro Lys Ala Arg Arg Ser Glu Gly Arg Ser Trp Ala Gln Pro Gly 
65                  70                  75                  80  


Tyr Pro Trp Pro Leu Tyr Gly Asn Glu Gly Cys Gly Trp Ala Gly Trp 
                85                  90                  95      


Leu Leu Ser Pro Arg Gly Ser Arg Pro Ser Trp Gly Pro Asn Asp Pro 
            100                 105                 110         


Arg Arg Arg Ser Arg Asn Leu Gly Lys Val Ile Asp Thr Leu Thr Cys 
        115                 120                 125             


Gly Phe Ala Asp Leu Met Gly Tyr Ile Pro Leu Val Gly Ala Pro Val 
    130                 135                 140                 


Gly Gly Val Ala Arg Ala Leu Ala His Gly Val Arg Ala Val Glu Asp 
145                 150                 155                 160 


Gly Ile Asn Tyr Ala Thr Gly Asn Leu Pro Gly Cys Ser Phe Ser Ile 
                165                 170                 175     


Phe Leu Leu Ala Leu Leu Ser Cys Leu Thr Val Pro Ala Ser Ala Ile 
            180                 185                 190         


Asn Tyr Arg Asn Thr Ser Gly Ile Tyr His Val Thr Asn Asp Cys Pro 
        195                 200                 205             


Asn Ser Ser Ile Val Tyr Glu Ala Asp His His Ile Leu His Leu Pro 
    210                 215                 220                 


Gly Cys Val Pro Cys Val Arg Xaa Gly Asn Gln Ser Arg Cys Trp Val 
225                 230                 235                 240 


Ala Leu Thr Pro Thr Val Ala Ala Pro Tyr Ile Gly Ala Pro Leu Glu 
                245                 250                 255     


Ser Leu Arg Ser His Val Asp Leu Met Val Gly Ala Ala Thr Val Cys 
            260                 265                 270         


Ser Ala Leu Tyr Ile Gly Asp Leu Cys Gly Gly Leu Phe Leu Val Gly 
        275                 280                 285             


Gln Met Phe Ser Phe Arg Pro Arg Arg His Trp Thr Thr Gln Asp Cys 
    290                 295                 300                 


Asn Cys Ser Ile Tyr Thr Gly His Ile Thr Gly His Arg Met Ala Trp 
305                 310                 315                 320 


Asp Met Met Met Asn Trp Ser Pro Thr Thr Thr Leu Val Leu Ala Gln 
                325                 330                 335     


Val Met Arg Ile Pro Ser Thr Leu Val Asp Leu Leu Ala Gly Gly His 
            340                 345                 350         


Trp Gly Val Leu Val Gly Val Ala Tyr Phe Ser Met Gln Ala Asn Trp 
        355                 360                 365             


Ala Lys Val Ile Leu Val Leu Phe Leu Phe Ala Gly Val Asp Ala Glu 
    370                 375                 380                 


Thr His Val Ser Gly Gly Ala Ala Gly Arg Thr Thr Xaa Gly Leu Thr 
385                 390                 395                 400 


Ser Leu Phe Ser Pro Gly Xaa Gln Gln Asn Leu Gln Leu Ile Asn Ser 
                405                 410                 415     


Asn Gly Ser Trp His Ile Asn Arg Thr Ala Leu Asn Cys Asn Asp Ser 
            420                 425                 430         


Leu Asn Thr Gly Phe Leu Ala Ser Leu Phe Tyr Thr His Lys Phe Asn 
        435                 440                 445             


Ser Ser Gly Cys Pro Glu Arg Leu Ala Ser Cys Lys Ser Leu Asp Ser 
    450                 455                 460                 


Phe Asp Gln Gly Trp Gly Pro Leu Gly Val Ala Asn Asn Ile Ser Gly 
465                 470                 475                 480 


Pro Ser Asp Asp Arg Pro Tyr Cys Trp His Tyr Pro Pro Arg Pro Cys 
                485                 490                 495     


Gly Ile Val Pro Ala Ser Ser Val Cys Gly Pro Val Tyr Cys Phe Thr 
            500                 505                 510         


Pro Ser Pro Val Val Val Gly Thr Thr Asp Arg Leu Gly Val Pro Thr 
        515                 520                 525             


Tyr Thr Trp Gly Glu Asn Glu Ser Asp Val Phe Leu Leu Asn Ser Thr 
    530                 535                 540                 


Arg Pro Pro Gln Gly Ala Trp Phe Gly Cys Val Trp Met Asn Ser Thr 
545                 550                 555                 560 


Gly Phe Thr Lys Ala Cys Gly Ala Pro Pro Cys Glu Val Arg Thr Asn 
                565                 570                 575     


Asn Gly Thr Ser Thr Asp Trp Pro Cys Pro Thr Asp Cys Phe Arg Lys 
            580                 585                 590         


His Pro Glu Thr Thr Tyr Ala Lys Cys Gly Ser Gly Pro Trp Ile Thr 
        595                 600                 605             


Pro Arg Cys Leu Ile His Tyr Pro Tyr Arg Leu Trp His Tyr Pro Cys 
    610                 615                 620                 


Thr Val Asn Phe Thr Val Phe Lys Ile Arg Thr Phe Ile Gly Gly Ile 
625                 630                 635                 640 


Glu His Arg Met Glu Ala Ala Cys Asn Trp Thr Arg Gly Glu Val Cys 
                645                 650                 655     


Gly Leu Glu His Arg Asp Arg Ala Glu Leu Ser Pro Leu Leu Leu Ser 
            660                 665                 670         


Thr Thr Thr Trp Gln Xaa Leu Pro Cys Ser Phe Thr Thr Leu Pro Ala 
        675                 680                 685             


Leu Ser Thr Gly Leu Ile His Leu His Gln Asn Ile Val Asp Val Gln 
    690                 695                 700                 


Tyr Leu Tyr Gly Val Gly Ser Ala Val Val Ser Trp Ala Leu Lys Trp 
705                 710                 715                 720 


Glu Tyr Val Val Leu Ala Phe Leu Leu Leu Ala Asp Ala Arg Val Ser 
                725                 730                 735     


Ala Cys Leu Trp Met Met Phe Met Val Ser Gln Val Glu Ala Ala Leu 
            740                 745                 750         


Ser Asn Leu Ile Asn Ile Asn Ala Ala Ser Ala Ala Gly Thr His Gly 
        755                 760                 765             


Phe Trp Tyr Ala Ile Phe Phe Ile Cys Ile Ala Trp His Val Lys Gly 
    770                 775                 780                 


Arg Leu Pro Ala Ala Ala Thr Tyr Ala Ala Cys Gly Met Trp Pro Leu 
785                 790                 795                 800 


Leu Leu Leu Leu Leu Met Leu Pro Glu Arg Ala Tyr Ala Tyr Asp Arg 
                805                 810                 815     


Glu Val Ala Gly Ser Leu Gly Gly Ala Val Val Val Ala Leu Thr Ile 
            820                 825                 830         


Leu Thr Leu Ser Pro His Tyr Lys Ser Trp Leu Ala Arg Gly Leu Trp 
        835                 840                 845             


Trp Ile Gln Tyr Phe Ile Ala Arg Ala Glu Ala Leu Leu His Val Tyr 
    850                 855                 860                 


Val Pro Ser Phe Asp Val Arg Gly Pro Arg Asp Ser Leu Ile Ile Leu 
865                 870                 875                 880 


Ala Val Leu Ala Cys Pro His Leu Val Phe Asp Ile Thr Lys Tyr Leu 
                885                 890                 895     


Leu Ala Ile Leu Gly Pro Leu Tyr Ile Leu Gln Ala Ser Leu Leu Arg 
            900                 905                 910         


Val Pro Tyr Phe Val Arg Ala His Ala Leu Val Lys Ile Cys Ser Leu 
        915                 920                 925             


Leu Arg Gly Val Val Tyr Gly Lys Tyr Cys Gln Met Ala Val Leu Lys 
    930                 935                 940                 


Val Gly Ala Leu Thr Gly Thr Tyr Ile Tyr Asp His Leu Thr Pro Leu 
945                 950                 955                 960 


Ser Asp Trp Ala Ala Glu Gly Leu Arg Asp Leu Ala Val Ala Leu Glu 
                965                 970                 975     


Pro Val Val Phe Thr Pro Met Glu Lys Lys Val Ile Val Trp Gly Ala 
            980                 985                 990         


Asp Thr Ala Ala Cys Gly Asp Ile  Ile Xaa Gly Leu Pro  Val Ser Ala 
        995                 1000                 1005             


Arg Leu  Gly Asn Glu Ile Leu  Leu Gly Pro Ala Asp  Ser Glu Thr 
    1010                 1015                 1020             


Ser Lys  Gly Trp Arg Leu Leu  Ala Pro Ile Thr Ala  Tyr Ala Gln 
    1025                 1030                 1035             


Gln Thr  Arg Gly Leu Phe Ser  Thr Ile Ile Thr Ser  Leu Thr Gly 
    1040                 1045                 1050             


Arg Asp  Thr Asn Glu Asn Cys  Gly Glu Val Gln Val  Leu Ser Thr 
    1055                 1060                 1065             


Ala Thr  Gln Ser Phe Leu Gly  Thr Ala Val Asn Gly  Val Met Trp 
    1070                 1075                 1080             


Thr Val  Tyr His Gly Ala Gly  Ser Lys Thr Ile Ser  Gly Pro Lys 
    1085                 1090                 1095             


Gly Pro  Val Asn Gln Met Tyr  Thr Asn Val Asp Gln  Asp Leu Val 
    1100                 1105                 1110             


Gly Trp  Pro Ala Pro Pro Gly  Val Lys Ser Leu Ala  Pro Cys Thr 
    1115                 1120                 1125             


Cys Gly  Ala Ser Asp Leu Tyr  Leu Val Thr Arg His  Ala Asp Val 
    1130                 1135                 1140             


Val Pro  Val Arg Arg Arg Gly  Asp Thr Arg Gly Ala  Leu Leu Ser 
    1145                 1150                 1155             


Pro Arg  Pro Ile Ser Thr Leu  Lys Gly Ser Ser Gly  Gly Pro Leu 
    1160                 1165                 1170             


Leu Cys  Pro Met Gly His Ala  Ala Gly Ile Phe Arg  Ala Ala Val 
    1175                 1180                 1185             


Cys Thr  Arg Gly Val Ala Lys  Ala Val Asp Phe Val  Pro Val Glu 
    1190                 1195                 1200             


Ser Leu  Glu Thr Thr Met Arg  Ser Pro Val Phe Thr  Asp Asn Ser 
    1205                 1210                 1215             


Thr Pro  Pro Ala Val Pro Gln  Thr Tyr Gln Val Ala  His Leu His 
    1220                 1225                 1230             


Ala Pro  Thr Gly Ser Gly Lys  Ser Thr Lys Val Pro  Ala Ala Tyr 
    1235                 1240                 1245             


Ala Ala  Gln Gly Tyr Lys Val  Leu Val Leu Asn Pro  Ser Val Ala 
    1250                 1255                 1260             


Ala Thr  Leu Gly Phe Gly Ala  Tyr Met Ser Lys Ala  Tyr Gly Ile 
    1265                 1270                 1275             


Asp Pro  Asn Ile Arg Ser Gly  Val Arg Thr Ile Thr  Thr Gly Ala 
    1280                 1285                 1290             


Pro Ile  Thr Tyr Ser Thr Tyr  Gly Lys Phe Leu Ala  Asp Gly Gly 
    1295                 1300                 1305             


Cys Ser  Gly Gly Ala Tyr Asp  Ile Ile Ile Cys Asp  Glu Cys His 
    1310                 1315                 1320             


Ser Thr  Asp Ser Thr Thr Ile  Leu Gly Ile Gly Thr  Val Leu Asp 
    1325                 1330                 1335             


Gln Ala  Glu Thr Ala Gly Val  Arg Leu Val Val Leu  Ala Thr Ala 
    1340                 1345                 1350             


Thr Pro  Pro Gly Ser Val Thr  Thr Pro His Ser Asn  Ile Glu Glu 
    1355                 1360                 1365             


Val Ala  Leu Pro Thr Thr Gly  Glu Ile Pro Phe Tyr  Gly Lys Ala 
    1370                 1375                 1380             


Ile Pro  Leu Glu Leu Ile Lys  Gly Gly Arg His Leu  Ile Phe Cys 
    1385                 1390                 1395             


His Ser  Lys Lys Lys Cys Asp  Glu Leu Ala Lys Gln  Leu Thr Ser 
    1400                 1405                 1410             


Leu Gly  Leu Asn Ala Val Ala  Tyr Tyr Arg Gly Leu  Asp Val Ser 
    1415                 1420                 1425             


Val Ile  Pro Thr Ser Gly Asp  Val Val Val Cys Ala  Thr Asp Ala 
    1430                 1435                 1440             


Leu Met  Thr Gly Phe Thr Gly  Asp Phe Asp Ser Val  Ile Asp Cys 
    1445                 1450                 1455             


Asn Thr  Ser Val Ile Gln Thr  Val Asp Phe Ser Leu  Asp Pro Thr 
    1460                 1465                 1470             


Phe Ser  Ile Glu Thr Thr Thr  Val Pro Gln Asp Ala  Val Ser Arg 
    1475                 1480                 1485             


Ser Gln  Arg Arg Gly Arg Thr  Gly Arg Gly Arg Leu  Gly Ile Tyr 
    1490                 1495                 1500             


Arg Tyr  Val Thr Pro Gly Glu  Arg Pro Ser Gly Ile  Phe Asp Thr 
    1505                 1510                 1515             


Ser Val  Leu Cys Glu Cys Tyr  Asp Ala Gly Cys Ala  Trp Tyr Glu 
    1520                 1525                 1530             


Leu Thr  Pro Ala Glu Thr Thr  Thr Arg Leu Arg Ala  Tyr Phe Asn 
    1535                 1540                 1545             


Thr Pro  Gly Leu Pro Val Cys  Gln Asp His Leu Glu  Phe Trp Glu 
    1550                 1555                 1560             


Ser Val  Phe Thr Gly Leu Thr  Gln Ile Asp Gly His  Phe Leu Ser 
    1565                 1570                 1575             


Gln Thr  Lys Gln Ser Gly Glu  Asn Phe Pro Tyr Leu  Val Ala Tyr 
    1580                 1585                 1590             


Gln Ala  Thr Val Cys Ala Arg  Ala Leu Ala Pro Pro  Pro Ser Trp 
    1595                 1600                 1605             


Asp Thr  Met Trp Lys Cys Leu  Ile Arg Leu Lys Pro  Thr Leu His 
    1610                 1615                 1620             


Gly Pro  Thr Pro Leu Leu Tyr  Arg Leu Gly Ser Val  Gln Asn Glu 
    1625                 1630                 1635             


Val Thr  Leu Thr His Pro Ile  Thr Lys Tyr Ile Met  Ala Cys Met 
    1640                 1645                 1650             


Ser Ala  Asp Leu Glu Val Val  Thr Ser Thr Trp Val  Leu Val Gly 
    1655                 1660                 1665             


Gly Val  Leu Ala Ala Leu Ala  Ala Tyr Cys Leu Ser  Val Gly Ser 
    1670                 1675                 1680             


Val Val  Ile Val Gly Arg Val  Val Leu Ser Gly Gln  Pro Ala Val 
    1685                 1690                 1695             


Ile Pro  Asp Arg Glu Val Leu  Tyr Gln Gln Phe Asp  Glu Met Glu 
    1700                 1705                 1710             


Glu Cys  Ser Lys His Leu Pro  Leu Val Glu His Gly  Leu Gln Leu 
    1715                 1720                 1725             


Ala Glu  Gln Phe Lys Gln Lys  Ala Val Gly Leu Leu  Asn Phe Ala 
    1730                 1735                 1740             


Gly Lys  Gln Ala Gln Glu Ala  Thr Pro Val Ile Gln  Ser Asn Phe 
    1745                 1750                 1755             


Ala Lys  Leu Glu Gln Phe Trp  Ala Lys His Met Trp  Asn Phe Ile 
    1760                 1765                 1770             


Ser Gly  Ile Gln Tyr Leu Ala  Gly Leu Ser Thr Leu  Pro Gly Asn 
    1775                 1780                 1785             


Pro Ala  Ile Ala Ser Leu Met  Ser Phe Thr Ala Ala  Val Thr Ser 
    1790                 1795                 1800             


Pro Leu  Thr Thr Gln Gln Thr  Leu Leu Phe Asn Ile  Leu Gly Gly 
    1805                 1810                 1815             


Trp Val  Ala Ser Gln Ile Ala  Thr Pro Thr Ala Ser  Thr Ala Phe 
    1820                 1825                 1830             


Val Val  Ser Gly Leu Ala Gly  Ala Ala Val Gly Ser  Val Gly Leu 
    1835                 1840                 1845             


Gly Lys  Ile Leu Val Asp Ile  Leu Ala Gly Tyr Gly  Ala Gly Val 
    1850                 1855                 1860             


Ala Gly  Ala Val Val Thr Phe  Lys Ile Met Ser Gly  Glu Met Pro 
    1865                 1870                 1875             


Ser Thr  Glu Asp Leu Val Asn  Leu Leu Pro Ala Ile  Leu Ser Pro 
    1880                 1885                 1890             


Gly Ala  Leu Val Val Gly Val  Val Cys Ala Ala Ile  Leu Arg Arg 
    1895                 1900                 1905             


His Val  Gly Pro Gly Glu Gly  Ala Val Gln Trp Met  Asn Arg Leu 
    1910                 1915                 1920             


Ile Ala  Phe Ala Ser Arg Gly  Asn His Val Ser Pro  Thr His Tyr 
    1925                 1930                 1935             


Val Pro  Glu Ser Asp Ala Ala  Ala Arg Val Thr Gln  Ile Leu Ser 
    1940                 1945                 1950             


Ser Leu  Thr Val Thr Ser Leu  Leu Arg Arg Leu His  Lys Trp Ile 
    1955                 1960                 1965             


Asn Glu  Asp Cys Ser Thr Pro  Cys Ala Glu Ser Trp  Leu Trp Glu 
    1970                 1975                 1980             


Val Trp  Asp Trp Val Cys Thr  Val Leu Ser Asp Phe  Lys Thr Trp 
    1985                 1990                 1995             


Leu Lys  Ala Lys Leu Leu Pro  Leu Met Pro Gly Ile  Pro Phe Leu 
    2000                 2005                 2010             


Ser Cys  Gln Arg Gly Tyr Lys  Gly Glu Trp Arg Gly  Asp Gly Val 
    2015                 2020                 2025             


Met His  Thr Thr Cys Pro Cys  Gly Ala Glu Leu Ala  Gly His Ile 
    2030                 2035                 2040             


Lys Asn  Gly Ser Met Arg Ile  Thr Gly Pro Lys Thr  Cys Ser Asn 
    2045                 2050                 2055             


Thr Trp  His Gly Thr Phe Pro  Ile Asn Ala Tyr Thr  Thr Gly Pro 
    2060                 2065                 2070             


Gly Val  Pro Ile Pro Ala Pro  Asn Tyr Lys Phe Ala  Leu Trp Arg 
    2075                 2080                 2085             


Val Ser  Ala Glu Glu Tyr Val  Glu Val Arg Arg Val  Gly Asp Phe 
    2090                 2095                 2100             


His Tyr  Val Thr Gly Val Thr  Gln Asp Asn Ile Lys  Cys Pro Cys 
    2105                 2110                 2115             


Gln Val  Pro Ala Pro Glu Phe  Phe Thr Glu Val Asp  Gly Ile Arg 
    2120                 2125                 2130             


Leu His  Arg His Ala Pro Lys  Cys Lys Pro Leu Leu  Arg Asp Glu 
    2135                 2140                 2145             


Val Ser  Phe Ser Val Gly Leu  Asn Ser Phe Val Val  Gly Ser Gln 
    2150                 2155                 2160             


Leu Pro  Cys Glu Pro Glu Pro  Asp Val Ala Val Leu  Thr Ser Met 
    2165                 2170                 2175             


Leu Thr  Asp Pro Ser His Ile  Thr Ala Glu Thr Ala  Ser Arg Arg 
    2180                 2185                 2190             


Leu Ala  Arg Gly Ser Pro Pro  Ser Leu Ala Ser Ser  Ser Ala Ser 
    2195                 2200                 2205             


Gln Leu  Ser Ala Pro Ser Leu  Lys Ala Thr Cys Thr  Ala Arg His 
    2210                 2215                 2220             


Asp Ser  Pro Gly Thr Asp Leu  Leu Glu Ala Asn Leu  Leu Trp Gly 
    2225                 2230                 2235             


Ser Thr  Ala Thr Arg Val Glu  Thr Asp Glu Lys Val  Ile Ile Leu 
    2240                 2245                 2250             


Asp Ser  Phe Glu Pro Cys Val  Ala Glu Pro Asp Asp  Asp Arg Glu 
    2255                 2260                 2265             


Val Ser  Val Ala Ala Glu Ile  Leu Arg Pro Thr Lys  Lys Phe Pro 
    2270                 2275                 2280             


Pro Ala  Leu Pro Ile Trp Ala  Arg Pro Asp Tyr Asn  Pro Pro Leu 
    2285                 2290                 2295             


Thr Glu  Thr Trp Lys Gln Gln  Asp Tyr Lys Pro Pro  Thr Val His 
    2300                 2305                 2310             


Gly Cys  Ala Leu Pro Pro Ser  Lys Gln Pro Pro Val  Pro Pro Pro 
    2315                 2320                 2325             


Arg Arg  Lys Arg Thr Val Gln  Leu Thr Glu Ser Val  Val Ser Thr 
    2330                 2335                 2340             


Ala Leu  Ala Glu Leu Ala Ala  Lys Thr Phe Gly Gln  Ser Glu Leu 
    2345                 2350                 2355             


Gly Ser  Asp Ser Gly Ala Asp  Leu Thr Thr Gly Pro  Thr Glu Thr 
    2360                 2365                 2370             


Thr Asp  Ser Gly Pro Ile Leu  Val Asp Asp Ala Ser  Asp Asp Gly 
    2375                 2380                 2385             


Ser Tyr  Ser Ser Met Pro Pro  Leu Glu Gly Glu Pro  Gly Asp Pro 
    2390                 2395                 2400             


Asp Leu  Thr Ser Asp Gln Val  Glu Leu Gln Pro Pro  Pro Gln Gly 
    2405                 2410                 2415             


Gly Gly  Val Ala Pro Gly Ser  Gly Ser Gly Ser Trp  Ser Thr Val 
    2420                 2425                 2430             


Ser Gly  Ser Glu Asp Thr Val  Val Cys Cys Ser Met  Ser Tyr Ser 
    2435                 2440                 2445             


Trp Thr  Gly Ala Leu Val Thr  Pro Cys Ala Ala Glu  Glu Ser Lys 
    2450                 2455                 2460             


Leu Pro  Ile Ser Pro Leu Ser  Asn Ser Leu Leu Arg  His His Asn 
    2465                 2470                 2475             


Met Val  Tyr Ala Thr Thr Thr  Arg Ser Ala Val Thr  Arg Gln Lys 
    2480                 2485                 2490             


Lys Val  Thr Phe Asp Arg Leu  Gln Val Val Asp Asn  His Tyr Asn 
    2495                 2500                 2505             


Glu Thr  Leu Lys Glu Ile Lys  Ala Arg Ala Ser Arg  Val Lys Ala 
    2510                 2515                 2520             


Arg Leu  Leu Thr Thr Glu Glu  Ala Cys Asp Leu Thr  Pro Pro His 
    2525                 2530                 2535             


Ser Ala  Lys Ser Lys Phe Gly  Tyr Gly Ala Lys Asp  Val Arg Ser 
    2540                 2545                 2550             


His Ser  Arg Lys Ala Ile Asn  His Ile Asn Ser Val  Trp Glu Asp 
    2555                 2560                 2565             


Leu Leu  Glu Asp Asn Asn Thr  Pro Ile Pro Thr Thr  Ile Met Ala 
    2570                 2575                 2580             


Lys Asn  Glu Val Phe Ala Val  Asn Pro Ala Lys Gly  Gly Arg Lys 
    2585                 2590                 2595             


Pro Ala  Arg Leu Ile Val Tyr  Pro Asp Leu Gly Gly  Val Arg Val 
    2600                 2605                 2610             


Cys Glu  Lys Arg Ala Leu His  Asp Val Ile Asn Gln  Leu Pro Lys 
    2615                 2620                 2625             


Ala Val  Met Gly Ala Ala Tyr  Gly Phe Gln Tyr Ser  Pro Ala Gln 
    2630                 2635                 2640             


Arg Val  Glu Phe Leu Leu Thr  Ser Trp Lys Ser Lys  Lys Thr Pro 
    2645                 2650                 2655             


Met Gly  Phe Ser Tyr Asp Thr  Arg Cys Phe Asp Ser  Thr Val Thr 
    2660                 2665                 2670             


Glu Lys  Asp Ile Arg Thr Glu  Glu Glu Val Tyr Gln  Cys Cys Asp 
    2675                 2680                 2685             


Leu Glu  Pro Glu Ala Arg Lys  Val Ile Thr Ala Leu  Thr Glu Arg 
    2690                 2695                 2700             


Leu Tyr  Val Gly Gly Pro Met  His Asn Ser Lys Gly  Asp Leu Cys 
    2705                 2710                 2715             


Gly Tyr  Arg Arg Cys Arg Ala  Ser Gly Val Tyr Thr  Thr Ser Phe 
    2720                 2725                 2730             


Gly Asn  Thr Leu Thr Cys Tyr  Leu Lys Ala Thr Ala  Ala Ile Lys 
    2735                 2740                 2745             


Ala Ala  Gly Leu Arg Asp Cys  Thr Met Leu Val Cys  Gly Asp Asp 
    2750                 2755                 2760             


Leu Val  Val Ile Ala Glu Ser  Asp Gly Val Glu Glu  Asp Asn Arg 
    2765                 2770                 2775             


Ala Leu  Arg Ala Phe Thr Glu  Ala Met Thr Arg Tyr  Ser Ala Pro 
    2780                 2785                 2790             


Pro Gly  Asp Ala Pro Gln Pro  Ala Tyr Asp Leu Glu  Leu Ile Thr 
    2795                 2800                 2805             


Ser Cys  Ser Ser Asn Val Ser  Val Ala His Asp Ala  Thr Gly Lys 
    2810                 2815                 2820             


Lys Val  Tyr Tyr Leu Thr Arg  Asp Pro Glu Thr Pro  Leu Ala Arg 
    2825                 2830                 2835             


Ala Ala  Trp Glu Thr Val Arg  His Thr Pro Val Asn  Ser Trp Leu 
    2840                 2845                 2850             


Gly Asn  Ile Ile Val Tyr Ala  Pro Thr Ile Trp Val  Arg Met Val 
    2855                 2860                 2865             


Leu Met  Thr His Phe Phe Ser  Ile Leu Gln Ser Gln  Glu Ala Leu 
    2870                 2875                 2880             


Glu Lys  Ala Leu Asp Phe Asp  Met Tyr Gly Val Thr  Tyr Ser Ile 
    2885                 2890                 2895             


Thr Pro  Leu Asp Leu Pro Ala  Ile Ile Gln Arg Leu  His Gly Leu 
    2900                 2905                 2910             


Ser Ala  Phe Thr Leu His Gly  Tyr Ser Pro His Glu  Leu Asn Arg 
    2915                 2920                 2925             


Val Ala  Gly Ser Leu Arg Lys  Leu Gly Val Pro Pro  Leu Arg Ala 
    2930                 2935                 2940             


Trp Arg  His Arg Ala Arg Ala  Val Arg Ala Lys Leu  Ile Ala Gln 
    2945                 2950                 2955             


Gly Gly  Lys Ala Lys Ile Cys  Gly Ile Tyr Leu Phe  Asn Trp Ala 
    2960                 2965                 2970             


Val Lys  Thr Lys Leu Lys Leu  Thr Pro Leu Pro Ala  Ala Ala Asn 
    2975                 2980                 2985             


Leu Asp  Leu Ser Ser Trp Phe  Thr Val Gly Ala Gly  Gly Gly Asp 
    2990                 2995                 3000             


Ile Tyr  His Ser Val Ser Arg  Ala Arg Pro Arg Tyr  Leu Leu Leu 
    3005                 3010                 3015             


Cys Leu  Leu Leu Leu Ser Val  Gly Val Gly Ile Phe  Leu Leu Pro 
    3020                 3025                 3030             


Ala Arg  
    3035 


<210>  103
<211>  3013
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic Sequence


<220>
<221>  misc_feature
<222>  (178)..(178)
<223>  Xaa can be any amino acid

<220>
<221>  misc_feature
<222>  (189)..(189)
<223>  Xaa can be any amino acid

<220>
<221>  misc_feature
<222>  (232)..(232)
<223>  Xaa can be any amino acid

<220>
<221>  misc_feature
<222>  (251)..(251)
<223>  Xaa can be any amino acid

<220>
<221>  misc_feature
<222>  (257)..(257)
<223>  Xaa can be any amino acid

<220>
<221>  misc_feature
<222>  (285)..(285)
<223>  Xaa can be any amino acid

<220>
<221>  misc_feature
<222>  (297)..(297)
<223>  Xaa can be any amino acid

<220>
<221>  misc_feature
<222>  (300)..(300)
<223>  Xaa can be any amino acid

<220>
<221>  misc_feature
<222>  (333)..(333)
<223>  Xaa can be any amino acid

<220>
<221>  misc_feature
<222>  (365)..(365)
<223>  Xaa can be any amino acid

<220>
<221>  misc_feature
<222>  (384)..(384)
<223>  Xaa can be any amino acid

<220>
<221>  misc_feature
<222>  (386)..(386)
<223>  Xaa can be any amino acid

<220>
<221>  misc_feature
<222>  (391)..(391)
<223>  Xaa can be any amino acid

<220>
<221>  misc_feature
<222>  (396)..(398)
<223>  Xaa can be any amino acid

<220>
<221>  misc_feature
<222>  (404)..(404)
<223>  Xaa can be any amino acid

<220>
<221>  misc_feature
<222>  (442)..(442)
<223>  Xaa can be any amino acid

<220>
<221>  misc_feature
<222>  (444)..(444)
<223>  Xaa can be any amino acid

<220>
<221>  misc_feature
<222>  (476)..(476)
<223>  Xaa can be any amino acid

<220>
<221>  misc_feature
<222>  (502)..(502)
<223>  Xaa can be any amino acid

<220>
<221>  misc_feature
<222>  (523)..(523)
<223>  Xaa can be any amino acid

<220>
<221>  misc_feature
<222>  (525)..(525)
<223>  Xaa can be any amino acid

<220>
<221>  misc_feature
<222>  (529)..(529)
<223>  Xaa can be any amino acid

<220>
<221>  misc_feature
<222>  (532)..(532)
<223>  Xaa can be any amino acid

<220>
<221>  misc_feature
<222>  (547)..(547)
<223>  Xaa can be any amino acid

<220>
<221>  misc_feature
<222>  (723)..(723)
<223>  Xaa can be any amino acid

<220>
<221>  misc_feature
<222>  (742)..(742)
<223>  Xaa can be any amino acid

<220>
<221>  misc_feature
<222>  (763)..(763)
<223>  Xaa can be any amino acid

<220>
<221>  misc_feature
<222>  (773)..(773)
<223>  Xaa can be any amino acid

<220>
<221>  misc_feature
<222>  (775)..(775)
<223>  Xaa can be any amino acid

<220>
<221>  misc_feature
<222>  (779)..(779)
<223>  Xaa can be any amino acid

<220>
<221>  misc_feature
<222>  (794)..(794)
<223>  Xaa can be any amino acid

<220>
<221>  misc_feature
<222>  (825)..(825)
<223>  Xaa can be any amino acid

<220>
<221>  misc_feature
<222>  (839)..(839)
<223>  Xaa can be any amino acid

<220>
<221>  misc_feature
<222>  (844)..(844)
<223>  Xaa can be any amino acid

<220>
<221>  misc_feature
<222>  (857)..(857)
<223>  Xaa can be any amino acid

<220>
<221>  misc_feature
<222>  (905)..(905)
<223>  Xaa can be any amino acid

<220>
<221>  misc_feature
<222>  (908)..(908)
<223>  Xaa can be any amino acid

<220>
<221>  misc_feature
<222>  (914)..(914)
<223>  Xaa can be any amino acid

<220>
<221>  misc_feature
<222>  (931)..(931)
<223>  Xaa can be any amino acid

<220>
<221>  misc_feature
<222>  (1020)..(1021)
<223>  Xaa can be any amino acid

<220>
<221>  misc_feature
<222>  (1088)..(1088)
<223>  Xaa can be any amino acid

<220>
<221>  misc_feature
<222>  (1114)..(1114)
<223>  Xaa can be any amino acid

<220>
<221>  misc_feature
<222>  (1118)..(1118)
<223>  Xaa can be any amino acid

<220>
<221>  misc_feature
<222>  (1384)..(1384)
<223>  Xaa can be any amino acid

<220>
<221>  misc_feature
<222>  (1613)..(1613)
<223>  Xaa can be any amino acid

<220>
<221>  misc_feature
<222>  (1756)..(1756)
<223>  Xaa can be any amino acid

<220>
<221>  misc_feature
<222>  (2262)..(2262)
<223>  Xaa can be any amino acid

<220>
<221>  misc_feature
<222>  (2356)..(2356)
<223>  Xaa can be any amino acid

<220>
<221>  misc_feature
<222>  (2374)..(2374)
<223>  Xaa can be any amino acid

<220>
<221>  misc_feature
<222>  (2385)..(2385)
<223>  Xaa can be any amino acid

<220>
<221>  misc_feature
<222>  (2540)..(2540)
<223>  Xaa can be any amino acid

<220>
<221>  misc_feature
<222>  (2601)..(2601)
<223>  Xaa can be any amino acid

<220>
<221>  misc_feature
<222>  (2636)..(2636)
<223>  Xaa can be any amino acid

<220>
<221>  misc_feature
<222>  (2674)..(2674)
<223>  Xaa can be any amino acid

<220>
<221>  misc_feature
<222>  (2994)..(2994)
<223>  Xaa can be any amino acid

<220>
<221>  misc_feature
<222>  (3002)..(3002)
<223>  Xaa can be any amino acid

<400>  103

Met Ser Thr Asn Pro Lys Pro Gln Arg Lys Thr Lys Arg Asn Thr Asn 
1               5                   10                  15      


Arg Arg Pro Gln Asp Val Lys Phe Pro Gly Gly Gly Gln Ile Val Gly 
            20                  25                  30          


Gly Val Tyr Leu Leu Pro Arg Arg Gly Pro Arg Leu Gly Val Arg Ala 
        35                  40                  45              


Thr Arg Lys Thr Ser Glu Arg Ser Gln Pro Arg Gly Arg Arg Gln Pro 
    50                  55                  60                  


Ile Pro Lys Ala Arg Arg Pro Thr Gly Arg Ser Trp Gly Gln Pro Gly 
65                  70                  75                  80  


Tyr Pro Trp Pro Leu Tyr Ala Asn Glu Gly Leu Gly Trp Ala Gly Trp 
                85                  90                  95      


Leu Leu Ser Pro Arg Gly Ser Arg Pro Asn Trp Gly Pro Asn Asp Pro 
            100                 105                 110         


Arg Arg Lys Ser Arg Asn Leu Gly Lys Val Ile Asp Thr Leu Thr Cys 
        115                 120                 125             


Gly Phe Ala Asp Leu Met Gly Tyr Ile Pro Leu Val Gly Gly Pro Val 
    130                 135                 140                 


Gly Gly Val Ala Arg Ala Leu Ala His Gly Val Arg Val Leu Glu Asp 
145                 150                 155                 160 


Gly Ile Asn Tyr Ala Thr Gly Asn Leu Pro Gly Cys Ser Phe Ser Ile 
                165                 170                 175     


Phe Xaa Leu Ala Leu Leu Ser Cys Leu Thr Val Pro Xaa Ser Ala Val 
            180                 185                 190         


Pro Tyr Arg Asn Ala Ser Gly Val Tyr His Val Thr Asn Asp Cys Pro 
        195                 200                 205             


Asn Ser Ser Ile Val Tyr Glu Ala Glu Asn Leu Ile Leu His Ala Pro 
    210                 215                 220                 


Gly Cys Val Pro Cys Val Arg Xaa Gly Asn Val Ser Arg Cys Trp Val 
225                 230                 235                 240 


Gln Ile Thr Pro Thr Leu Ser Ala Pro Ser Xaa Gly Ala Val Thr Ala 
                245                 250                 255     


Xaa Leu Arg Arg Ala Val Asp Tyr Leu Ala Gly Gly Ala Ala Leu Cys 
            260                 265                 270         


Ser Ala Leu Tyr Val Gly Asp Ala Cys Gly Ala Val Xaa Leu Val Gly 
        275                 280                 285             


Gln Met Phe Thr Tyr Ser Pro Arg Xaa His Thr Xaa Val Gln Asp Cys 
    290                 295                 300                 


Asn Cys Ser Ile Tyr Ser Gly His Ile Thr Gly His Arg Met Ala Trp 
305                 310                 315                 320 


Asp Met Met Met Asn Trp Ser Pro Thr Thr Ala Leu Xaa Met Ala Gln 
                325                 330                 335     


Leu Leu Arg Ile Pro Gln Val Val Ile Asp Ile Ile Ala Gly Ala His 
            340                 345                 350         


Trp Gly Val Leu Phe Ala Ala Ala Tyr Phe Ala Ser Xaa Ala Asn Trp 
        355                 360                 365             


Ala Lys Val Ile Leu Val Leu Phe Leu Phe Ala Gly Val Asp Ala Xaa 
    370                 375                 380                 


Thr Xaa Thr Val Gly Gly Xaa Ala Gly Gln Gly Xaa Xaa Xaa Leu Thr 
385                 390                 395                 400 


Ser Phe Phe Xaa Pro Gly Pro Gln Gln Asn Leu Gln Leu Ile Asn Thr 
                405                 410                 415     


Asn Gly Ser Trp His Ile Asn Arg Thr Ala Leu Asn Cys Asn Asp Ser 
            420                 425                 430         


Leu Gln Thr Gly Phe Ile Ala Gly Leu Xaa Tyr Xaa His Lys Phe Asn 
        435                 440                 445             


Ser Ser Gly Cys Pro Gln Arg Met Ala Ser Cys Arg Pro Leu Ala Ala 
    450                 455                 460                 


Phe Asp Gln Gly Trp Gly Thr Ile Ser Tyr Ala Xaa Val Ser Gly Pro 
465                 470                 475                 480 


Ser Asp Asp Lys Pro Tyr Cys Trp His Tyr Pro Pro Arg Pro Cys Gly 
                485                 490                 495     


Val Val Pro Ala Arg Xaa Val Cys Gly Pro Val Tyr Cys Phe Thr Pro 
            500                 505                 510         


Ser Pro Val Val Val Gly Thr Thr Asp Arg Xaa Gly Xaa Pro Thr Tyr 
        515                 520                 525             


Xaa Trp Gly Xaa Asn Glu Thr Asp Ile Phe Leu Leu Asn Asn Thr Arg 
    530                 535                 540                 


Pro Pro Xaa Gly Asn Trp Phe Gly Cys Thr Trp Met Asn Ser Thr Gly 
545                 550                 555                 560 


Phe Val Lys Thr Cys Gly Ala Pro Pro Cys Asn Leu Gly Pro Thr Gly 
                565                 570                 575     


Asn Asn Ser Leu Lys Cys Pro Thr Asp Cys Phe Arg Lys His Pro Asp 
            580                 585                 590         


Ala Thr Tyr Thr Lys Cys Gly Ser Gly Pro Trp Leu Thr Pro Arg Cys 
        595                 600                 605             


Leu Val His Tyr Pro Tyr Arg Leu Trp His Tyr Pro Cys Thr Val Asn 
    610                 615                 620                 


Tyr Thr Ile Phe Lys Val Arg Met Phe Ile Gly Gly Leu Glu His Arg 
625                 630                 635                 640 


Leu Glu Ala Ala Cys Asn Trp Thr Arg Gly Glu Arg Cys Asp Leu Glu 
                645                 650                 655     


Asp Arg Asp Arg Ala Glu Leu Ser Pro Leu Leu His Thr Thr Thr Gln 
            660                 665                 670         


Trp Ala Ile Leu Pro Cys Ser Phe Thr Pro Thr Pro Ala Leu Ser Thr 
        675                 680                 685             


Gly Leu Ile His Leu His Gln Asn Ile Val Asp Thr Gln Tyr Leu Tyr 
    690                 695                 700                 


Gly Leu Ser Ser Ser Ile Val Ser Trp Ala Val Lys Trp Glu Tyr Ile 
705                 710                 715                 720 


Val Leu Xaa Phe Leu Leu Leu Ala Asp Ala Arg Ile Cys Thr Cys Leu 
                725                 730                 735     


Trp Ile Leu Leu Leu Xaa Cys Gln Ala Glu Ala Ala Leu Glu Asn Val 
            740                 745                 750         


Ile Val Leu Asn Ala Ala Ala Ala Ala Gly Xaa His Gly Phe Phe Trp 
        755                 760                 765             


Gly Leu Leu Val Xaa Cys Xaa Ala Trp His Xaa Lys Gly Arg Leu Val 
    770                 775                 780                 


Pro Gly Ala Thr Tyr Leu Cys Leu Gly Xaa Trp Pro Leu Leu Leu Leu 
785                 790                 795                 800 


Leu Leu Leu Leu Pro Gln Arg Ala Leu Ala Leu Asp Ser Ser Asp Gly 
                805                 810                 815     


Gly Thr Val Gly Cys Leu Val Leu Xaa Ile Leu Thr Ile Phe Thr Leu 
            820                 825                 830         


Thr Pro Gly Tyr Lys Lys Xaa Val Val Leu Val Xaa Trp Trp Leu Gln 
        835                 840                 845             


Tyr Phe Ile Ala Arg Val Glu Ala Xaa Ile His Val Trp Val Pro Pro 
    850                 855                 860                 


Leu Gln Val Arg Gly Gly Arg Asp Ala Ile Ile Met Leu Thr Cys Leu 
865                 870                 875                 880 


Phe His Pro Ala Leu Gly Phe Glu Val Thr Lys Ile Leu Leu Gly Ile 
                885                 890                 895     


Leu Gly Pro Leu Tyr Leu Leu Gln Xaa Ser Leu Xaa Lys Val Pro Tyr 
            900                 905                 910         


Phe Xaa Arg Ala Arg Ala Leu Leu Arg Ala Cys Leu Leu Ala Lys His 
        915                 920                 925             


Leu Val Xaa Gly Lys Tyr Val Gln Ala Ala Leu Leu His Leu Gly Arg 
    930                 935                 940                 


Leu Thr Gly Thr Tyr Ile Tyr Asp His Leu Ala Pro Met Lys Asp Trp 
945                 950                 955                 960 


Ala Ala Ser Gly Leu Arg Asp Leu Ala Val Ala Thr Glu Pro Ile Ile 
                965                 970                 975     


Phe Ser Pro Met Glu Thr Lys Val Ile Thr Trp Gly Ala Asp Thr Ala 
            980                 985                 990         


Ala Cys Gly Asp Ile Leu Ala Gly  Leu Pro Val Ser Ala  Arg Arg Gly 
        995                 1000                 1005             


Arg Glu  Ile Phe Leu Gly Pro  Ala Asp Asp Ile Xaa  Xaa Ala Gly 
    1010                 1015                 1020             


Trp Arg  Leu Leu Ala Pro Ile  Thr Ala Tyr Ala Gln  Gln Thr Arg 
    1025                 1030                 1035             


Gly Val  Leu Gly Ala Ile Val  Val Ser Leu Thr Gly  Arg Asp Lys 
    1040                 1045                 1050             


Asn Glu  Ala Glu Gly Glu Val  Gln Val Leu Ser Thr  Ala Thr Gln 
    1055                 1060                 1065             


Thr Phe  Leu Gly Thr Cys Ile  Asn Gly Val Met Trp  Thr Val Phe 
    1070                 1075                 1080             


His Gly  Ala Gly Xaa Lys Thr  Leu Ala Gly Pro Lys  Gly Pro Val 
    1085                 1090                 1095             


Val Gln  Met Tyr Thr Asn Val  Asp Lys Asp Leu Val  Gly Trp Pro 
    1100                 1105                 1110             


Xaa Pro  Pro Gly Xaa Arg Ser  Leu Thr Pro Cys Thr  Cys Gly Ser 
    1115                 1120                 1125             


Ala Asp  Leu Tyr Leu Val Thr  Arg His Ala Asp Val  Ile Pro Ala 
    1130                 1135                 1140             


Arg Arg  Arg Gly Asp Thr Arg  Ala Ser Leu Leu Ser  Pro Arg Pro 
    1145                 1150                 1155             


Ile Ser  Tyr Leu Lys Gly Ser  Ser Gly Gly Pro Ile  Met Cys Pro 
    1160                 1165                 1170             


Ser Gly  His Val Val Gly Val  Phe Arg Ala Ala Val  Cys Thr Arg 
    1175                 1180                 1185             


Gly Val  Ala Lys Ala Leu Asp  Phe Ile Pro Val Glu  Asn Leu Glu 
    1190                 1195                 1200             


Thr Thr  Met Arg Ser Pro Val  Phe Thr Asp Asn Ser  Thr Pro Pro 
    1205                 1210                 1215             


Ala Val  Pro His Glu Phe Gln  Val Gly His Leu His  Ala Pro Thr 
    1220                 1225                 1230             


Gly Ser  Gly Lys Ser Thr Lys  Val Pro Ala Ala Tyr  Ala Ala Gln 
    1235                 1240                 1245             


Gly Tyr  Lys Val Leu Val Leu  Asn Pro Ser Val Ala  Ala Thr Leu 
    1250                 1255                 1260             


Gly Phe  Gly Ala Tyr Met Ser  Arg Ala Tyr Gly Val  Asp Pro Asn 
    1265                 1270                 1275             


Ile Arg  Thr Gly Val Arg Thr  Val Thr Thr Gly Ala  Ala Ile Thr 
    1280                 1285                 1290             


Tyr Ser  Thr Tyr Gly Lys Phe  Leu Ala Asp Gly Gly  Cys Ser Gly 
    1295                 1300                 1305             


Gly Ala  Tyr Asp Val Ile Ile  Cys Asp Glu Cys His  Ser Gln Asp 
    1310                 1315                 1320             


Ala Thr  Thr Ile Leu Gly Ile  Gly Thr Val Leu Asp  Gln Ala Glu 
    1325                 1330                 1335             


Thr Ala  Gly Ala Arg Leu Val  Val Leu Ala Thr Ala  Thr Pro Pro 
    1340                 1345                 1350             


Gly Ser  Val Thr Thr Pro His  Pro Asn Ile Glu Glu  Val Ala Leu 
    1355                 1360                 1365             


Pro Ser  Glu Gly Glu Ile Pro  Phe Tyr Gly Arg Ala  Ile Pro Leu 
    1370                 1375                 1380             


Xaa Leu  Ile Lys Gly Gly Arg  His Leu Ile Phe Cys  His Ser Lys 
    1385                 1390                 1395             


Lys Lys  Cys Asp Glu Leu Ala  Lys Gln Leu Thr Ser  Leu Gly Val 
    1400                 1405                 1410             


Asn Ala  Val Ala Tyr Tyr Arg  Gly Leu Asp Val Ala  Val Ile Pro 
    1415                 1420                 1425             


Ala Thr  Gly Asp Val Val Val  Cys Ser Thr Asp Ala  Leu Met Thr 
    1430                 1435                 1440             


Gly Phe  Thr Gly Asp Phe Asp  Ser Val Ile Asp Cys  Asn Thr Ala 
    1445                 1450                 1455             


Val Thr  Gln Thr Val Asp Phe  Ser Leu Asp Pro Thr  Phe Thr Ile 
    1460                 1465                 1470             


Glu Thr  Thr Thr Val Pro Gln  Asp Ala Val Ser Arg  Ser Gln Arg 
    1475                 1480                 1485             


Arg Gly  Arg Thr Gly Arg Gly  Arg His Gly Ile Tyr  Arg Tyr Val 
    1490                 1495                 1500             


Ser Ser  Gly Glu Arg Pro Ser  Gly Ile Phe Asp Ser  Val Val Leu 
    1505                 1510                 1515             


Cys Glu  Cys Tyr Asp Ala Gly  Cys Ala Trp Tyr Asp  Leu Thr Pro 
    1520                 1525                 1530             


Ala Glu  Thr Thr Val Arg Leu  Arg Ala Tyr Leu Asn  Thr Pro Gly 
    1535                 1540                 1545             


Leu Pro  Val Cys Gln Asp His  Leu Glu Phe Trp Glu  Gly Val Phe 
    1550                 1555                 1560             


Thr Gly  Leu Thr Asn Ile Asp  Ala His Met Leu Ser  Gln Thr Lys 
    1565                 1570                 1575             


Gln Gly  Gly Glu Asn Phe Pro  Tyr Leu Val Ala Tyr  Gln Ala Thr 
    1580                 1585                 1590             


Val Cys  Val Arg Ala Lys Ala  Pro Pro Pro Ser Trp  Asp Thr Met 
    1595                 1600                 1605             


Trp Lys  Cys Met Xaa Arg Leu  Lys Pro Thr Leu Thr  Gly Pro Thr 
    1610                 1615                 1620             


Pro Leu  Leu Tyr Arg Leu Gly  Ala Val Gln Asn Glu  Ile Thr Leu 
    1625                 1630                 1635             


Thr His  Pro Ile Thr Lys Tyr  Ile Met Ala Cys Met  Ser Ala Asp 
    1640                 1645                 1650             


Leu Glu  Val Ile Thr Ser Thr  Trp Val Leu Val Gly  Gly Val Val 
    1655                 1660                 1665             


Ala Ala  Leu Ala Ala Tyr Cys  Leu Thr Val Gly Ser  Val Ala Ile 
    1670                 1675                 1680             


Val Gly  Arg Ile Ile Leu Ser  Gly Arg Pro Ala Ile  Ile Pro Asp 
    1685                 1690                 1695             


Arg Glu  Val Leu Tyr Gln Gln  Phe Asp Glu Met Glu  Glu Cys Ser 
    1700                 1705                 1710             


Ala Ser  Leu Pro Tyr Met Asp  Glu Ala Arg Ala Ile  Ala Glu Gln 
    1715                 1720                 1725             


Phe Lys  Glu Lys Val Leu Gly  Leu Ile Gly Thr Ala  Gly Gln Lys 
    1730                 1735                 1740             


Ala Glu  Thr Leu Lys Pro Ala  Ala Thr Ser Met Trp  Xaa Lys Ala 
    1745                 1750                 1755             


Glu Gln  Phe Trp Ala Lys His  Met Trp Asn Phe Val  Ser Gly Ile 
    1760                 1765                 1770             


Gln Tyr  Leu Ala Gly Leu Ser  Thr Leu Pro Gly Asn  Pro Ala Val 
    1775                 1780                 1785             


Ala Thr  Leu Met Ser Phe Thr  Ala Ala Val Thr Ser  Pro Leu Thr 
    1790                 1795                 1800             


Thr Gln  Gln Thr Leu Leu Phe  Asn Ile Leu Gly Gly  Trp Val Ala 
    1805                 1810                 1815             


Ser Gln  Ile Ala Pro Pro Thr  Ala Ala Thr Ala Phe  Val Val Ser 
    1820                 1825                 1830             


Gly Met  Ala Gly Ala Ala Val  Gly Ser Ile Gly Leu  Gly Arg Val 
    1835                 1840                 1845             


Leu Ile  Asp Ile Leu Ala Gly  Tyr Gly Ala Gly Val  Ala Gly Ala 
    1850                 1855                 1860             


Leu Val  Ala Phe Lys Ile Met  Cys Gly Glu Arg Pro  Thr Ala Glu 
    1865                 1870                 1875             


Asp Leu  Val Asn Leu Leu Pro  Ser Ile Leu Cys Pro  Gly Ala Leu 
    1880                 1885                 1890             


Val Val  Gly Val Ile Cys Ala  Ala Val Leu Arg Arg  His Ile Gly 
    1895                 1900                 1905             


Pro Gly  Glu Gly Ala Val Gln  Trp Met Asn Arg Leu  Ile Ala Phe 
    1910                 1915                 1920             


Ala Ser  Arg Gly Asn His Val  Ser Pro Thr His Tyr  Val Pro Glu 
    1925                 1930                 1935             


Thr Asp  Ala Ser Ala Lys Val  Thr Gln Leu Leu Ser  Ser Leu Thr 
    1940                 1945                 1950             


Val Thr  Ser Leu Leu Lys Arg  Leu His Thr Trp Ile  Gly Glu Asp 
    1955                 1960                 1965             


Tyr Ser  Thr Pro Cys Asp Gly  Thr Trp Leu Arg Ala  Ile Trp Asp 
    1970                 1975                 1980             


Trp Val  Cys Thr Ala Leu Thr  Asp Phe Lys Ala Trp  Leu Gln Ala 
    1985                 1990                 1995             


Lys Leu  Leu Pro Gln Leu Pro  Gly Val Pro Phe Leu  Ser Cys Gln 
    2000                 2005                 2010             


Arg Gly  Tyr Lys Gly Val Trp  Arg Gly Asp Gly Val  Asn Ser Thr 
    2015                 2020                 2025             


Lys Cys  Pro Cys Gly Ala Thr  Ile Ser Gly His Val  Lys Asn Gly 
    2030                 2035                 2040             


Thr Met  Arg Ile Val Gly Pro  Lys Leu Cys Ser Asn  Thr Trp His 
    2045                 2050                 2055             


Gly Thr  Phe Pro Ile Asn Ala  Thr Thr Thr Gly Pro  Ser Val Pro 
    2060                 2065                 2070             


Ala Pro  Ala Pro Asn Tyr Lys  Phe Ala Leu Trp Arg  Val Gly Ala 
    2075                 2080                 2085             


Ala Asp  Tyr Ala Glu Val Arg  Arg Val Gly Asp Tyr  His Tyr Ile 
    2090                 2095                 2100             


Thr Gly  Val Thr Gln Asp Asn  Leu Lys Cys Pro Cys  Gln Val Pro 
    2105                 2110                 2115             


Ser Pro  Glu Phe Phe Thr Glu  Leu Asp Gly Val Arg  Ile His Arg 
    2120                 2125                 2130             


Tyr Ala  Pro Pro Cys Asn Pro  Leu Leu Arg Glu Glu  Val Cys Phe 
    2135                 2140                 2145             


Ser Val  Gly Leu His Ser Tyr  Val Val Gly Ser Gln  Leu Pro Cys 
    2150                 2155                 2160             


Glu Pro  Glu Pro Asp Val Thr  Val Leu Thr Ser Met  Leu Ser Asp 
    2165                 2170                 2175             


Pro Ala  His Ile Thr Ala Glu  Thr Ala Lys Arg Arg  Leu Asp Arg 
    2180                 2185                 2190             


Gly Ser  Pro Pro Ser Leu Ala  Ser Ser Ser Ala Ser  Gln Leu Ser 
    2195                 2200                 2205             


Ala Pro  Ser Leu Lys Ala Thr  Cys Thr Thr Gln Gly  His His Pro 
    2210                 2215                 2220             


Asp Ala  Asp Leu Ile Glu Ala  Asn Leu Leu Trp Arg  Gln Cys Met 
    2225                 2230                 2235             


Gly Gly  Asn Ile Thr Arg Val  Glu Ala Glu Asn Lys  Val Val Ile 
    2240                 2245                 2250             


Leu Asp  Ser Phe Glu Pro Leu  Lys Xaa Glu Glu Asp  Asp Arg Glu 
    2255                 2260                 2265             


Ile Ser  Val Ser Ala Asp Cys  Phe Arg Arg Gly Pro  Ala Phe Pro 
    2270                 2275                 2280             


Pro Ala  Leu Pro Ile Trp Ala  Arg Pro Gly Tyr Asp  Pro Pro Leu 
    2285                 2290                 2295             


Leu Glu  Thr Trp Lys Arg Pro  Asp Tyr Asp Pro Pro  Gln Val Ser 
    2300                 2305                 2310             


Gly Cys  Pro Leu Pro Pro Ala  Gly Leu Pro Pro Val  Pro Pro Pro 
    2315                 2320                 2325             


Arg Arg  Lys Arg Lys Pro Val  Glu Leu Ser Asp Ser  Thr Val Ser 
    2330                 2335                 2340             


Gln Val  Leu Ala Asp Leu Ala  Asp Ala Arg Phe Lys  Xaa Asp Thr 
    2345                 2350                 2355             


Pro Ser  Ile Glu Gly Gln Asp  Ser Ala Val Gly Thr  Ser Ser Gln 
    2360                 2365                 2370             


Xaa Asp  Ser Gly Pro Glu Glu  Lys Arg Asp Asp Xaa  Ser Asp Ala 
    2375                 2380                 2385             


Ala Ser  Tyr Ser Ser Met Pro  Pro Leu Glu Gly Glu  Pro Gly Asp 
    2390                 2395                 2400             


Pro Asp  Leu Ser Ser Gly Ser  Trp Ser Thr Val Ser  Asp Glu Asp 
    2405                 2410                 2415             


Ser Val  Val Cys Cys Ser Met  Ser Tyr Ser Trp Thr  Gly Ala Leu 
    2420                 2425                 2430             


Ile Thr  Pro Cys Ser Ala Glu  Glu Glu Lys Leu Pro  Ile Asn Pro 
    2435                 2440                 2445             


Leu Ser  Asn Thr Leu Leu Arg  His His Asn Leu Val  Tyr Ser Thr 
    2450                 2455                 2460             


Ser Ser  Arg Ser Ala Gly Leu  Arg Gln Lys Lys Val  Thr Phe Asp 
    2465                 2470                 2475             


Arg Leu  Gln Val Leu Asp Asp  His Tyr Arg Glu Val  Val Asp Glu 
    2480                 2485                 2490             


Met Lys  Arg Leu Ala Ser Lys  Val Lys Ala Arg Leu  Leu Pro Leu 
    2495                 2500                 2505             


Glu Glu  Ala Cys Gly Leu Thr  Pro Pro His Ser Ala  Arg Ser Lys 
    2510                 2515                 2520             


Tyr Gly  Tyr Gly Ala Lys Glu  Val Arg Ser Leu Asp  Lys Lys Ala 
    2525                 2530                 2535             


Leu Xaa  His Ile Glu Gly Val  Trp Gln Asp Leu Leu  Asp Asp Ser 
    2540                 2545                 2550             


Asp Thr  Pro Leu Pro Thr Thr  Ile Met Ala Lys Asn  Glu Val Phe 
    2555                 2560                 2565             


Ala Val  Glu Pro Ser Lys Gly  Gly Lys Lys Pro Ala  Arg Leu Ile 
    2570                 2575                 2580             


Val Tyr  Pro Asp Leu Gly Val  Arg Val Cys Glu Lys  Arg Ala Leu 
    2585                 2590                 2595             


Tyr Asp  Xaa Ala Gln Lys Leu  Pro Thr Ala Leu Met  Gly Pro Ser 
    2600                 2605                 2610             


Tyr Gly  Phe Gln Tyr Ser Pro  Ala Gln Arg Val Glu  Phe Leu Leu 
    2615                 2620                 2625             


Lys Thr  Trp Lys Ser Lys Lys  Xaa Pro Met Ala Phe  Ser Tyr Asp 
    2630                 2635                 2640             


Thr Arg  Cys Phe Asp Ser Thr  Val Thr Glu His Asp  Ile Met Thr 
    2645                 2650                 2655             


Glu Glu  Ser Ile Tyr Gln Ser  Cys Asp Leu Gln Pro  Glu Ala Arg 
    2660                 2665                 2670             


Xaa Ala  Ile Arg Ser Leu Thr  Gln Arg Leu Tyr Cys  Gly Gly Pro 
    2675                 2680                 2685             


Met Tyr  Asn Ser Lys Gly Gln  Gln Cys Gly Tyr Arg  Arg Cys Arg 
    2690                 2695                 2700             


Ala Ser  Gly Val Phe Thr Thr  Ser Met Gly Asn Thr  Met Thr Cys 
    2705                 2710                 2715             


Tyr Ile  Lys Ala Leu Ala Ser  Cys Arg Ala Ala Lys  Leu Arg Asp 
    2720                 2725                 2730             


Cys Thr  Leu Leu Val Cys Gly  Asp Asp Leu Val Ala  Ile Cys Glu 
    2735                 2740                 2745             


Ser Gln  Gly Thr His Glu Asp  Glu Ala Ser Leu Arg  Ala Phe Thr 
    2750                 2755                 2760             


Glu Ala  Met Thr Arg Tyr Ser  Ala Pro Pro Gly Asp  Pro Pro Val 
    2765                 2770                 2775             


Pro Ala  Tyr Asp Leu Glu Leu  Val Thr Ser Cys Ser  Ser Asn Val 
    2780                 2785                 2790             


Ser Val  Ala Arg Asp Ala Ser  Gly Asn Arg Val Tyr  Tyr Leu Thr 
    2795                 2800                 2805             


Arg Asp  Pro Gln Val Pro Leu  Ala Arg Ala Ala Trp  Glu Thr Ala 
    2810                 2815                 2820             


Lys His  Ser Pro Val Asn Ser  Trp Leu Gly Asn Ile  Ile Met Tyr 
    2825                 2830                 2835             


Ala Pro  Thr Leu Trp Ala Arg  Ile Val Leu Met Thr  His Phe Phe 
    2840                 2845                 2850             


Ser Val  Leu Gln Ser Gln Glu  Gln Leu Glu Lys Ala  Leu Ala Phe 
    2855                 2860                 2865             


Glu Met  Tyr Gly Ser Val Tyr  Ser Val Thr Pro Leu  Asp Leu Pro 
    2870                 2875                 2880             


Ala Ile  Ile Gln Arg Leu His  Gly Leu Ser Ala Phe  Ser Leu His 
    2885                 2890                 2895             


Ser Tyr  Ser Pro Ser Glu Ile  Asn Arg Val Ala Ser  Cys Leu Arg 
    2900                 2905                 2910             


Lys Leu  Gly Val Pro Pro Leu  Arg Ala Trp Arg His  Arg Ala Arg 
    2915                 2920                 2925             


Ala Val  Arg Ala Lys Leu Ile  Ala Gln Gly Gly Lys  Ala Ala Ile 
    2930                 2935                 2940             


Cys Gly  Ile Tyr Leu Phe Asn  Trp Ala Val Lys Thr  Lys Arg Lys 
    2945                 2950                 2955             


Leu Thr  Pro Leu Ala Asp Ala  Asp Arg Leu Asp Leu  Ser Ser Trp 
    2960                 2965                 2970             


Phe Thr  Val Gly Ala Gly Gly  Gly Asp Ile Tyr His  Ser Met Ser 
    2975                 2980                 2985             


Arg Ala  Arg Pro Arg Xaa Leu  Leu Cys Leu Leu Leu  Leu Xaa Val 
    2990                 2995                 3000             


Gly Val  Gly Ile Phe Leu Leu  Pro Ala Arg 
    3005                 3010             


<210>  104
<211>  3014
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic Sequence


<220>
<221>  misc_feature
<222>  (195)..(195)
<223>  Xaa can be any amino acid

<220>
<221>  misc_feature
<222>  (237)..(237)
<223>  Xaa can be any amino acid

<220>
<221>  misc_feature
<222>  (389)..(389)
<223>  Xaa can be any amino acid

<220>
<221>  misc_feature
<222>  (400)..(400)
<223>  Xaa can be any amino acid

<220>
<221>  misc_feature
<222>  (403)..(403)
<223>  Xaa can be any amino acid

<220>
<221>  misc_feature
<222>  (572)..(572)
<223>  Xaa can be any amino acid

<220>
<221>  misc_feature
<222>  (1877)..(1877)
<223>  Xaa can be any amino acid

<220>
<221>  misc_feature
<222>  (1944)..(1944)
<223>  Xaa can be any amino acid

<220>
<221>  misc_feature
<222>  (1967)..(1967)
<223>  Xaa can be any amino acid

<400>  104

Met Ser Thr Leu Pro Lys Pro Gln Arg Lys Thr Lys Arg Asn Thr Asn 
1               5                   10                  15      


Arg Arg Pro Met Asp Val Lys Phe Pro Gly Gly Gly Gln Ile Val Gly 
            20                  25                  30          


Gly Val Tyr Leu Leu Pro Arg Arg Gly Pro Arg Leu Gly Val Arg Ala 
        35                  40                  45              


Thr Arg Lys Thr Ser Glu Arg Ser Gln Pro Arg Gly Arg Arg Gln Pro 
    50                  55                  60                  


Ile Pro Lys Ala Arg Gln Pro Thr Gly Arg His Trp Ala Gln Pro Gly 
65                  70                  75                  80  


Tyr Pro Trp Pro Leu Tyr Gly Asn Glu Gly Cys Gly Trp Ala Gly Trp 
                85                  90                  95      


Leu Leu Ser Pro Arg Gly Ser Arg Pro His Trp Gly Pro Asn Asp Pro 
            100                 105                 110         


Arg Arg Arg Ser Arg Asn Leu Gly Lys Val Ile Asp Thr Leu Thr Cys 
        115                 120                 125             


Gly Phe Ala Asp Leu Met Gly Tyr Ile Pro Val Val Gly Ala Pro Leu 
    130                 135                 140                 


Gly Gly Val Ala Ala Ala Leu Ala His Gly Val Arg Ala Ile Glu Asp 
145                 150                 155                 160 


Gly Ile Asn Tyr Ala Thr Gly Asn Leu Pro Gly Cys Ser Phe Ser Ile 
                165                 170                 175     


Phe Leu Leu Ala Leu Leu Ser Cys Leu Thr Thr Pro Ala Ser Ala Val 
            180                 185                 190         


His Tyr Xaa Asn Ser Ser Gly Ile Tyr His Leu Thr Asn Asp Cys Pro 
        195                 200                 205             


Asn Ser Ser Ile Val Tyr Glu Ala Asp Ala Met Ile Leu His Leu Pro 
    210                 215                 220                 


Gly Cys Val Pro Cys Val Arg Val Gly Asn Gln Ser Xaa Cys Trp Val 
225                 230                 235                 240 


Pro Val Ser Pro Thr Leu Ala Val Pro Asn Ala Ser Thr Pro Ala Thr 
                245                 250                 255     


Gly Phe Arg Arg His Val Asp Leu Leu Val Gly Ala Ala Ala Phe Cys 
            260                 265                 270         


Ser Ala Leu Tyr Ile Gly Asp Leu Cys Gly Gly Val Phe Leu Val Gly 
        275                 280                 285             


Gln Leu Phe Thr Phe Arg Pro Arg Arg His Gln Thr Val Gln Asp Cys 
    290                 295                 300                 


Asn Cys Ser Ile Tyr Thr Gly His Val Thr Gly His Arg Met Ala Trp 
305                 310                 315                 320 


Asp Met Met Met Asn Trp Ser Pro Thr Ala Thr Leu Val Leu Ser Ser 
                325                 330                 335     


Ile Leu Arg Val Pro Gln Leu Leu Leu Asp Ile Phe Leu Gly Gly His 
            340                 345                 350         


Trp Gly Val Leu Gly Ala Val Leu Tyr Tyr Ser Met Val Ala Asn Trp 
        355                 360                 365             


Ala Lys Val Leu Ala Val Leu Leu Leu Phe Ala Gly Val Asp Ala Thr 
    370                 375                 380                 


Thr Thr Thr Gly Xaa Ala Ala Gly Arg Thr Thr Ser Gly Leu Thr Xaa 
385                 390                 395                 400 


Leu Phe Xaa Pro Gly Ala Lys Gln Asn Leu Gln Leu Ile Asn Thr Asn 
                405                 410                 415     


Gly Ser Trp His Ile Asn Arg Thr Ala Leu Asn Cys Asn Asp Ser Leu 
            420                 425                 430         


Gln Thr Gly Phe Ile Ala Gly Leu Phe Tyr Thr His Lys Phe Asn Ser 
        435                 440                 445             


Ser Gly Cys Pro Glu Arg Met Ser Ser Cys Lys Pro Leu Thr Asp Phe 
    450                 455                 460                 


Asp Gln Gly Trp Gly Pro Ile Thr Tyr Ala Asn Ile Ser Gly Pro Ser 
465                 470                 475                 480 


Glu Asp Arg Pro Tyr Cys Trp His Tyr Ala Pro Arg Pro Cys Asp Val 
                485                 490                 495     


Val Pro Ala Arg Thr Val Cys Gly Pro Val Tyr Cys Phe Thr Pro Ser 
            500                 505                 510         


Pro Val Val Val Gly Thr Thr Asp Arg Arg Gly Leu Pro Thr Tyr Thr 
        515                 520                 525             


Trp Gly Glu Asn Glu Thr Asp Val Phe Leu Leu Glu Ser Leu Arg Pro 
    530                 535                 540                 


Pro Thr Gly Gly Trp Phe Gly Cys Thr Trp Met Asn Ser Thr Gly Phe 
545                 550                 555                 560 


Val Lys Thr Cys Gly Ala Pro Pro Cys Asn Ile Xaa Pro Asn Ser Ser 
                565                 570                 575     


Asn Asn Ser Leu Leu Cys Pro Thr Asp Cys Phe Arg Lys His Pro Glu 
            580                 585                 590         


Ala Thr Tyr Ala Arg Cys Gly Ser Gly Pro Trp Leu Thr Pro Arg Cys 
        595                 600                 605             


Leu Val Asp Tyr Pro Tyr Arg Leu Trp His Tyr Pro Cys Thr Val Asn 
    610                 615                 620                 


Phe Thr Ile His Lys Val Arg Met Phe Val Gly Gly Val Glu His Arg 
625                 630                 635                 640 


Phe Asp Ala Ala Cys Asn Trp Thr Arg Gly Glu Arg Cys Glu Leu Asp 
                645                 650                 655     


Asp Arg Asp Arg Ile Glu Met Ser Pro Leu Leu Phe Ser Thr Thr Glu 
            660                 665                 670         


Leu Ala Ile Leu Pro Cys Ser Phe Thr Thr Met Pro Ala Leu Ser Thr 
        675                 680                 685             


Gly Leu Ile His Leu His Gln Asn Ile Val Asp Val Gln Tyr Leu Tyr 
    690                 695                 700                 


Gly Val Ser Ser Ser Val Val Ser Trp Ala Val Lys Trp Glu Tyr Val 
705                 710                 715                 720 


Val Leu Ala Phe Leu Val Leu Ala Asp Ala Arg Ile Cys Ala Cys Leu 
                725                 730                 735     


Trp Leu Met Leu Leu Ile Gly Gln Ala Glu Ala Ala Leu Glu Asn Leu 
            740                 745                 750         


Ile Val Leu Asn Ala Ala Ser Ala Ala Ser Thr Gln Gly Trp Trp Trp 
        755                 760                 765             


Gly Leu Leu Phe Leu Cys Cys Ala Trp Tyr Val Lys Gly Arg Leu Val 
    770                 775                 780                 


Pro Ala Cys Thr Tyr Ala Leu Leu Gln Leu Trp Pro Leu Leu Leu Leu 
785                 790                 795                 800 


Val Leu Ala Leu Pro Arg Arg Ala Tyr Ala Tyr Asp Asn Glu Gln Ala 
                805                 810                 815     


Ala Ser Leu Gly Ala Leu Val Leu Leu Val Ile Thr Ile Phe Thr Leu 
            820                 825                 830         


Thr Pro Ala Tyr Lys Gln Leu Leu Val Ser Phe Leu Trp Trp Asn Gln 
        835                 840                 845             


Tyr Phe Ile Ala Arg Ala Glu Ala Met Leu His Val Trp Val Pro Ser 
    850                 855                 860                 


Leu Arg Val Arg Gly Gly Arg Asp Ala Val Ile Leu Leu Thr Cys Leu 
865                 870                 875                 880 


Leu His Pro Gln Leu Gly Phe Glu Val Thr Lys Ile Leu Leu Ala Leu 
                885                 890                 895     


Leu Gly Pro Leu Tyr Leu Leu Gln Tyr Ser Leu Leu Lys Val Pro Tyr 
            900                 905                 910         


Phe Val Arg Ala His Ile Leu Leu Arg Ala Cys Leu Leu Val Arg Arg 
        915                 920                 925             


Leu Ala Gly Gly Lys Tyr Val Gln Ala Cys Leu Leu Arg Leu Gly Ala 
    930                 935                 940                 


Trp Thr Gly Thr Tyr Ile Tyr Asp His Leu Ala Pro Leu Ser Asp Trp 
945                 950                 955                 960 


Ala Ser Asp Gly Leu Arg Asp Leu Ala Val Ala Val Glu Pro Val Ile 
                965                 970                 975     


Phe Ser Pro Met Glu Lys Lys Val Ile Thr Trp Gly Ala Asp Thr Ala 
            980                 985                 990         


Ala Cys Gly Asp Ile Leu Ala Gly  Leu Pro Val Ser Ala  Arg Arg Gly 
        995                 1000                 1005             


Asn Leu  Val Leu Leu Gly Pro  Ala Asp Asp Met Lys  Arg Gly Gly 
    1010                 1015                 1020             


Trp Arg  Leu Leu Ala Pro Ile  Thr Ala Tyr Ala Gln  Gln Thr Arg 
    1025                 1030                 1035             


Gly Leu  Leu Gly Thr Ile Val  Thr Ser Leu Thr Gly  Arg Asp Lys 
    1040                 1045                 1050             


Asn Glu  Val Glu Gly Glu Val  Gln Val Val Ser Thr  Ala Thr Gln 
    1055                 1060                 1065             


Ser Phe  Leu Ala Thr Ser Ile  Asn Gly Val Leu Trp  Thr Val Tyr 
    1070                 1075                 1080             


His Gly  Ala Gly Ser Lys Thr  Leu Ala Gly Pro Lys  Gly Pro Val 
    1085                 1090                 1095             


Cys Gln  Met Tyr Thr Asn Val  Asp Gln Asp Leu Val  Gly Trp Pro 
    1100                 1105                 1110             


Ala Pro  Pro Gly Ala Arg Ser  Leu Thr Pro Cys Thr  Cys Gly Ser 
    1115                 1120                 1125             


Ser Asp  Leu Tyr Leu Val Thr  Arg Asn Ala Asp Val  Ile Pro Ala 
    1130                 1135                 1140             


Arg Arg  Arg Gly Asp Thr Arg  Ala Ala Leu Leu Ser  Pro Arg Pro 
    1145                 1150                 1155             


Ile Ser  Thr Leu Lys Gly Ser  Ser Gly Gly Pro Ile  Leu Cys Pro 
    1160                 1165                 1170             


Ser Gly  His Val Val Gly Leu  Phe Arg Ala Ala Val  Cys Thr Arg 
    1175                 1180                 1185             


Gly Val  Ala Lys Ser Leu Asp  Phe Val Pro Val Glu  Asn Met Glu 
    1190                 1195                 1200             


Thr Thr  Met Arg Ser Pro Ser  Phe Thr Asp Asn Ser  Thr Pro Pro 
    1205                 1210                 1215             


Ala Val  Pro Gln Thr Tyr Gln  Val Gly Tyr Leu His  Ala Pro Thr 
    1220                 1225                 1230             


Gly Ser  Gly Lys Ser Thr Lys  Val Pro Ala Ala Tyr  Ala Ser Gln 
    1235                 1240                 1245             


Gly Tyr  Lys Val Leu Val Leu  Asn Pro Ser Val Ala  Ala Thr Leu 
    1250                 1255                 1260             


Gly Phe  Gly Ser Tyr Met Ser  Lys Ala His Gly Ile  Asp Pro Asn 
    1265                 1270                 1275             


Ile Arg  Thr Gly Val Arg Thr  Ile Thr Thr Gly Gly  Ala Ile Thr 
    1280                 1285                 1290             


Tyr Ser  Thr Tyr Gly Lys Phe  Leu Ala Asp Gly Gly  Cys Ser Gly 
    1295                 1300                 1305             


Gly Ala  Tyr Asp Ile Ile Ile  Cys Asp Glu Cys His  Ser Thr Asp 
    1310                 1315                 1320             


Pro Thr  Thr Val Leu Gly Ile  Gly Thr Val Leu Asp  Gln Ala Glu 
    1325                 1330                 1335             


Thr Ala  Gly Val Arg Leu Thr  Val Leu Ala Thr Ala  Thr Pro Pro 
    1340                 1345                 1350             


Gly Ser  Val Thr Val Pro His  Pro Asn Ile Thr Glu  Thr Ala Leu 
    1355                 1360                 1365             


Pro Thr  Thr Gly Glu Ile Pro  Phe Tyr Gly Lys Ala  Ile Pro Leu 
    1370                 1375                 1380             


Glu Tyr  Ile Lys Gly Gly Arg  His Leu Ile Phe Cys  His Ser Lys 
    1385                 1390                 1395             


Lys Lys  Cys Asp Glu Leu Ala  Lys Gln Leu Thr Ser  Leu Gly Leu 
    1400                 1405                 1410             


Asn Ala  Val Ala Phe Tyr Arg  Gly Val Asp Val Ser  Val Ile Pro 
    1415                 1420                 1425             


Thr Ser  Gly Asp Val Val Val  Cys Ala Thr Asp Ala  Leu Met Thr 
    1430                 1435                 1440             


Gly Tyr  Thr Gly Asp Phe Asp  Ser Val Ile Asp Cys  Asn Val Ala 
    1445                 1450                 1455             


Val Thr  Gln Val Val Asp Phe  Ser Leu Asp Pro Thr  Phe Ser Ile 
    1460                 1465                 1470             


Glu Thr  Thr Thr Val Pro Gln  Asp Ala Val Ser Arg  Ser Gln Arg 
    1475                 1480                 1485             


Arg Gly  Arg Thr Gly Arg Gly  Lys Pro Gly Val Tyr  Arg Tyr Val 
    1490                 1495                 1500             


Ser Gln  Gly Glu Arg Pro Ser  Gly Met Phe Asp Thr  Val Val Leu 
    1505                 1510                 1515             


Cys Glu  Ala Tyr Asp Thr Gly  Cys Ala Trp Tyr Glu  Leu Thr Pro 
    1520                 1525                 1530             


Ser Glu  Thr Thr Val Arg Leu  Arg Ala Tyr Leu Asn  Thr Pro Gly 
    1535                 1540                 1545             


Leu Pro  Val Cys Gln Asp His  Leu Glu Phe Trp Glu  Gly Val Phe 
    1550                 1555                 1560             


Thr Gly  Leu Thr His Ile Asp  Ala His Phe Leu Ser  Gln Thr Lys 
    1565                 1570                 1575             


Gln Gly  Gly Glu Asn Phe Ala  Tyr Leu Val Ala Tyr  Gln Ala Thr 
    1580                 1585                 1590             


Val Cys  Ala Arg Ala Lys Ala  Pro Pro Pro Ser Trp  Asp Thr Met 
    1595                 1600                 1605             


Trp Lys  Cys Leu Ile Arg Leu  Lys Pro Met Leu Thr  Gly Pro Thr 
    1610                 1615                 1620             


Pro Leu  Leu Tyr Arg Leu Gly  Ala Val Gln Asn Glu  Ile Thr Thr 
    1625                 1630                 1635             


Thr His  Pro Ile Thr Lys Tyr  Ile Met Thr Cys Met  Ser Ala Asp 
    1640                 1645                 1650             


Leu Glu  Val Ile Thr Ser Thr  Trp Val Leu Val Gly  Gly Val Leu 
    1655                 1660                 1665             


Ala Ala  Leu Ala Ala Tyr Cys  Leu Ser Val Gly Cys  Val Val Ile 
    1670                 1675                 1680             


Cys Gly  Arg Ile Thr Thr Thr  Gly Lys Pro Ala Val  Ile Pro Asp 
    1685                 1690                 1695             


Arg Glu  Val Leu Tyr Gln Gln  Phe Asp Glu Met Glu  Glu Cys Ser 
    1700                 1705                 1710             


Arg His  Ile Pro Tyr Leu Ala  Glu Gly Gln Gln Ile  Ala Glu Gln 
    1715                 1720                 1725             


Phe Lys  Gln Lys Val Leu Gly  Leu Leu Gln Thr Thr  Ala Lys Gln 
    1730                 1735                 1740             


Ala Glu  Glu Leu Lys Pro Ala  Val His Ser Ala Trp  Pro Lys Leu 
    1745                 1750                 1755             


Glu Gln  Phe Trp Gln Lys His  Leu Trp Asn Phe Val  Ser Gly Ile 
    1760                 1765                 1770             


Gln Tyr  Leu Ala Gly Leu Ser  Thr Leu Pro Gly Asn  Pro Ala Val 
    1775                 1780                 1785             


Ala Ser  Leu Met Ser Phe Ser  Ala Ser Leu Thr Ser  Pro Leu Ser 
    1790                 1795                 1800             


Thr Ser  Thr Thr Leu Leu Leu  Asn Ile Leu Gly Gly  Trp Val Ala 
    1805                 1810                 1815             


Ser Gln  Leu Ala Pro Pro Thr  Ala Ser Thr Ala Phe  Val Val Ser 
    1820                 1825                 1830             


Gly Leu  Ala Gly Ala Ala Val  Gly Ser Ile Gly Leu  Gly Arg Val 
    1835                 1840                 1845             


Leu Val  Asp Ile Leu Ala Gly  Tyr Gly Ala Gly Val  Ser Gly Ala 
    1850                 1855                 1860             


Leu Val  Ala Phe Lys Ile Met  Ser Gly Glu Thr Pro  Ala Xaa Glu 
    1865                 1870                 1875             


Asp Met  Val Asn Leu Leu Pro  Ala Leu Leu Ser Pro  Gly Ala Leu 
    1880                 1885                 1890             


Val Val  Gly Val Val Cys Ala  Ala Ile Leu Arg Arg  His Val Gly 
    1895                 1900                 1905             


Pro Ala  Glu Gly Ala Thr Gln  Trp Met Asn Arg Leu  Ile Ala Phe 
    1910                 1915                 1920             


Ala Ser  Arg Gly Asn His Val  Ser Pro Thr His Tyr  Val Pro Glu 
    1925                 1930                 1935             


Thr Asp  Ala Ser Arg Xaa Val  Thr Thr Ile Leu Ser  Ser Leu Thr 
    1940                 1945                 1950             


Ile Thr  Ser Leu Leu Arg Arg  Leu His Glu Trp Ile  Asn Xaa Asp 
    1955                 1960                 1965             


Trp Ser  Thr Pro Cys Ala Thr  Ser Trp Leu Arg Asp  Ile Trp Asp 
    1970                 1975                 1980             


Trp Val  Cys Thr Val Leu Ser  Asp Phe Lys Thr Trp  Leu Lys Ala 
    1985                 1990                 1995             


Lys Leu  Val Pro Ser Leu Pro  Gly Ile Pro Phe Leu  Ser Cys Gln 
    2000                 2005                 2010             


Arg Gly  Phe Arg Gly Val Trp  Arg Gly Asp Gly Val  Cys His Thr 
    2015                 2020                 2025             


Thr Cys  Thr Cys Gly Ala Val  Ile Ala Gly His Val  Lys Asn Gly 
    2030                 2035                 2040             


Thr Met  Lys Ile Ser Gly Pro  Arg Thr Cys Ser Asn  Thr Trp His 
    2045                 2050                 2055             


Gly Thr  Phe Pro Ile Asn Ala  Thr Thr Thr Gly Pro  Ser Val Pro 
    2060                 2065                 2070             


Ile Pro  Glu Pro Asn Tyr Lys  Arg Ala Leu Trp Arg  Val Ser Ala 
    2075                 2080                 2085             


Glu Asp  Tyr Val Glu Val Val  Arg Val Gly Asp Cys  His Tyr Val 
    2090                 2095                 2100             


Val Gly  Ala Thr Ala Asp Asn  Leu Lys Cys Pro Cys  Gln Val Pro 
    2105                 2110                 2115             


Ala Pro  Glu Phe Phe Thr Glu  Val Asp Gly Val Arg  Leu His Arg 
    2120                 2125                 2130             


Tyr Ala  Pro Pro Cys Lys Pro  Leu Leu Arg Asp Glu  Val Thr Phe 
    2135                 2140                 2145             


Ser Val  Gly Leu Ser Ser Tyr  Ala Ile Gly Ser Gln  Leu Pro Cys 
    2150                 2155                 2160             


Glu Pro  Glu Pro Asp Val Thr  Val Val Thr Ser Met  Leu Thr Asp 
    2165                 2170                 2175             


Pro Ser  His Ile Thr Ala Glu  Thr Ala Ala Arg Arg  Leu Ala Arg 
    2180                 2185                 2190             


Gly Ser  Pro Pro Ser Leu Ala  Ser Ser Ser Ala Ser  Gln Leu Ser 
    2195                 2200                 2205             


Ala Pro  Ser Leu Lys Ala Thr  Cys Thr Thr His Gly  Asp His Pro 
    2210                 2215                 2220             


Asp Ala  Glu Leu Ile Glu Ala  Asn Leu Leu Trp Arg  Gln Glu Met 
    2225                 2230                 2235             


Gly Gly  Asn Ile Thr Arg Val  Glu Ser Glu Asn Lys  Val Ile Val 
    2240                 2245                 2250             


Leu Asp  Ser Phe Asp Pro Leu  Val Ala Glu Tyr Asp  Asp Arg Glu 
    2255                 2260                 2265             


Ile Ser  Val Ser Ala Glu Cys  His Arg Pro Pro Arg  Pro Lys Phe 
    2270                 2275                 2280             


Pro Pro  Ala Leu Pro Ile Trp  Ala Arg Pro Asp Tyr  Asn Pro Pro 
    2285                 2290                 2295             


Leu Leu  Glu Thr Trp Lys Ala  Pro Asp Tyr Glu Pro  Pro Val Val 
    2300                 2305                 2310             


Ser Gly  Cys Ala Leu Pro Pro  Pro Gly Pro Pro Pro  Ile Pro Pro 
    2315                 2320                 2325             


Pro Arg  Arg Lys Lys Val Val  His Leu Asp Glu Ser  Thr Val Ser 
    2330                 2335                 2340             


His Ala  Leu Ala Gln Leu Ala  Glu Lys Ser Phe Pro  Glu Ser Ser 
    2345                 2350                 2355             


Ser Asp  Ser Thr Ser Ser Asp  Ser Gly Leu Ser Ile  Thr Ser Ser 
    2360                 2365                 2370             


Gly Ser  Pro Glu Pro Thr Thr  Asp Asp Asp Ala Cys  Ser Glu Ala 
    2375                 2380                 2385             


Gly Ser  Tyr Ser Ser Met Pro  Pro Leu Glu Gly Glu  Pro Gly Asp 
    2390                 2395                 2400             


Pro Asp  Leu Ser Ser Gly Ser  Trp Ser Thr Val Ser  Glu Glu Asp 
    2405                 2410                 2415             


Ser Val  Val Cys Cys Ser Met  Ser Tyr Ser Trp Thr  Gly Ala Leu 
    2420                 2425                 2430             


Ile Thr  Pro Cys Ala Ala Glu  Glu Glu Lys Leu Pro  Ile Asn Pro 
    2435                 2440                 2445             


Leu Ser  Asn Ser Leu Ile Arg  His His Asn Leu Val  Tyr Ser Thr 
    2450                 2455                 2460             


Thr Ser  Arg Ser Ala Ser Leu  Arg Gln Lys Lys Val  Thr Phe Asp 
    2465                 2470                 2475             


Arg Val  Gln Val Leu Asp Gln  His Tyr Gln Asp Val  Leu Lys Glu 
    2480                 2485                 2490             


Ile Lys  Leu Arg Ala Ser Gln  Val Gln Ala Arg Leu  Leu Ser Thr 
    2495                 2500                 2505             


Glu Glu  Ala Cys Asp Leu Thr  Pro Pro His Ser Ala  Arg Ser Lys 
    2510                 2515                 2520             


Phe Gly  Tyr Gly Ala Lys Asp  Val Arg Ser His Ala  Ser Lys Ala 
    2525                 2530                 2535             


Ile Asn  His Ile Asn Ser Val  Trp Glu Asp Leu Leu  Glu Asp Asn 
    2540                 2545                 2550             


Gln Thr  Pro Ile Pro Thr Thr  Ile Met Ala Lys Asn  Glu Val Phe 
    2555                 2560                 2565             


Cys Val  Asp Pro Ser Lys Gly  Gly Arg Lys Pro Ala  Arg Leu Ile 
    2570                 2575                 2580             


Val Tyr  Pro Asp Leu Gly Val  Arg Val Cys Glu Lys  Arg Ala Leu 
    2585                 2590                 2595             


Tyr Asp  Ile Thr Arg Lys Leu  Pro Val Ala Val Met  Gly Asp Ala 
    2600                 2605                 2610             


Tyr Gly  Phe Gln Tyr Ser Pro  Lys Gln Arg Val Asp  Tyr Leu Leu 
    2615                 2620                 2625             


Lys Met  Trp Arg Ser Lys Lys  Thr Pro Met Gly Phe  Ser Tyr Asp 
    2630                 2635                 2640             


Thr Arg  Cys Phe Asp Ser Thr  Val Thr Glu Arg Asp  Ile Arg Thr 
    2645                 2650                 2655             


Glu His  Asp Ile Tyr Gln Ser  Cys Gln Leu Asp Pro  Glu Ala Arg 
    2660                 2665                 2670             


Lys Ala  Ile Thr Ser Leu Thr  Glu Arg Leu Tyr Val  Gly Gly Pro 
    2675                 2680                 2685             


Met Tyr  Asn Ser Lys Gly Gln  Ser Cys Gly Tyr Arg  Arg Cys Arg 
    2690                 2695                 2700             


Ala Ser  Gly Val Leu Pro Thr  Ser Leu Gly Asn Thr  Leu Thr Cys 
    2705                 2710                 2715             


Tyr Leu  Lys Ala Gln Ala Ala  Cys Arg Ala Ala Gly  Leu Lys Asp 
    2720                 2725                 2730             


Phe Asp  Met Leu Val Cys Gly  Asp Asp Leu Val Val  Ile Ser Glu 
    2735                 2740                 2745             


Ser Ala  Gly Val Gln Glu Asp  Ala Ala Ala Leu Arg  Ala Phe Thr 
    2750                 2755                 2760             


Glu Ala  Met Thr Arg Tyr Ser  Ala Pro Pro Gly Asp  Glu Pro Gln 
    2765                 2770                 2775             


Pro Thr  Tyr Asp Leu Glu Leu  Ile Thr Ser Cys Ser  Ser Asn Val 
    2780                 2785                 2790             


Ser Val  Ala His Asp Gly Thr  Gly Gln Arg Tyr Tyr  Tyr Leu Thr 
    2795                 2800                 2805             


Arg Asp  Pro Thr Thr Pro Leu  Ala Arg Ala Ala Trp  Glu Thr Ala 
    2810                 2815                 2820             


Arg His  Thr Pro Val Asn Ser  Trp Leu Gly Asn Ile  Ile Met Tyr 
    2825                 2830                 2835             


Ala Pro  Thr Ile Trp Val Arg  Met Val Leu Met Thr  His Phe Phe 
    2840                 2845                 2850             


Gln Ile  Leu Gln Ser Gln Glu  Gln Leu His Lys Ala  Leu Asp Phe 
    2855                 2860                 2865             


Asp Ile  Tyr Gly Val Thr Tyr  Ser Ile Thr Pro Leu  Asp Leu Pro 
    2870                 2875                 2880             


Ala Ile  Ile Gln Arg Leu His  Gly Met Ala Ala Phe  Ser Leu His 
    2885                 2890                 2895             


Gly Tyr  Ser Pro Gly Glu Leu  Asn Arg Val Ala Ala  Cys Leu Arg 
    2900                 2905                 2910             


Lys Leu  Gly Ala Pro Pro Leu  Arg Ala Trp Arg His  Arg Ala Arg 
    2915                 2920                 2925             


Ala Val  Arg Ala Lys Leu Ile  Ala Gln Gly Gly Lys  Ala Ala Ile 
    2930                 2935                 2940             


Cys Gly  Lys Tyr Leu Phe Asn  Trp Ala Val Lys Thr  Lys Leu Lys 
    2945                 2950                 2955             


Leu Thr  Pro Leu Arg Gly Ala  Ser Lys Leu Asp Leu  Ser Gly Trp 
    2960                 2965                 2970             


Phe Val  Ala Gly Tyr Ser Gly  Gly Asp Ile Tyr His  Ser Val Ser 
    2975                 2980                 2985             


Arg Ala  Arg Pro Arg Met Leu  Leu Leu Cys Leu Leu  Leu Leu Thr 
    2990                 2995                 3000             


Val Gly  Val Gly Ile Phe Leu  Leu Pro Ala Arg 
    3005                 3010                 


<210>  105
<211>  3013
<212>  PRT
<213>  hepatitis C virus

<400>  105

Met Ser Thr Asn Pro Lys Pro Gln Arg Leu Thr Lys Arg Asn Thr Val 
1               5                   10                  15      


Arg Arg Pro Gln Asn Val Lys Phe Pro Gly Gly Gly Gln Ile Val Gly 
            20                  25                  30          


Gly Val Tyr Leu Leu Pro Arg Arg Gly Pro Arg Leu Gly Val Arg Gly 
        35                  40                  45              


Thr Arg Lys Ser Ser Glu Arg Ser Gln Pro Arg Gly Arg Arg Gln Arg 
    50                  55                  60                  


Ile Pro Lys Ala Ala Ser Ser Gln Gly Lys Ala Trp Gly Lys Pro Gly 
65                  70                  75                  80  


Tyr Pro Trp Pro Leu Tyr Gly Asn Glu Gly Cys Gly Trp Ala Gly Trp 
                85                  90                  95      


Leu Leu Ser Pro Arg Gly Ser Arg Pro Thr Trp Gly Pro Thr Asp Pro 
            100                 105                 110         


Arg His Arg Ser Arg Asn Leu Gly Lys Val Ile Asp Thr Met Thr Cys 
        115                 120                 125             


Gly Phe Ala Asp Leu Met Gly Tyr Ile Pro Val Leu Gly Ala Pro Leu 
    130                 135                 140                 


Gly Gly Val Ala Arg Ala Leu Ala His Gly Val Arg Val Leu Glu Asp 
145                 150                 155                 160 


Gly Val Asn Tyr Ala Thr Gly Asn Leu Pro Gly Cys Ser Phe Ser Ile 
                165                 170                 175     


Phe Leu Leu Ala Leu Leu Ser Cys Leu Thr Val Pro Ala Ser Ala Tyr 
            180                 185                 190         


Glu Val Arg Asn Ser Ser Gly Val Tyr His Leu Thr Asn Asp Cys Pro 
        195                 200                 205             


Asn Ala Ser Ile Val Tyr Glu Thr Asp Asn Ala Ile Leu His Glu Pro 
    210                 215                 220                 


Gly Cys Val Pro Cys Val Arg Glu Gly Asn Thr Ser Arg Cys Trp Glu 
225                 230                 235                 240 


Pro Val Ala Pro Thr Leu Ala Val Arg Tyr Arg Gly Ala Leu Thr Asp 
                245                 250                 255     


Asp Leu Arg Thr His Ile Asp Leu Val Val Ala Ser Ala Thr Leu Cys 
            260                 265                 270         


Ser Ala Leu Tyr Val Gly Asp Ile Cys Gly Ala Ile Phe Ile Ala Ser 
        275                 280                 285             


Gln Ala Val Leu Trp Lys Pro Gly Gly Gly Arg Ile Val Gln Asp Cys 
    290                 295                 300                 


Asn Cys Ser Ile Tyr Pro Gly His Val Thr Gly His Arg Met Ala Trp 
305                 310                 315                 320 


Asp Met Met Gln Asn Trp Ala Pro Ala Leu Ser Met Val Ala Ala Tyr 
                325                 330                 335     


Ala Val Arg Val Pro Gly Val Ile Ile Thr Thr Val Ala Gly Gly His 
            340                 345                 350         


Trp Gly Val Leu Phe Gly Leu Ala Tyr Phe Gly Met Ala Gly Asn Trp 
        355                 360                 365             


Ala Lys Val Ile Leu Ile Met Leu Leu Met Ser Gly Val Asp Ala Glu 
    370                 375                 380                 


Thr Met Ala Val Gly Ala Arg Ala Ala His Thr Thr Gly Ala Leu Val 
385                 390                 395                 400 


Ser Leu Leu Asn Pro Gly Pro Ser Gln Arg Leu Gln Leu Ile Asn Thr 
                405                 410                 415     


Asn Gly Ser Trp His Ile Asn Arg Thr Ala Leu Asn Cys Asn Asp Ser 
            420                 425                 430         


Leu Gln Thr Gly Phe Ile Ala Ala Leu Phe Tyr Thr His Arg Phe Asn 
        435                 440                 445             


Ser Ser Gly Cys Pro Glu Arg Met Ala Ser Cys Lys Pro Leu Ser Asp 
    450                 455                 460                 


Phe Asp Gln Gly Trp Gly Pro Leu Trp Tyr Asn Ser Thr Glu Arg Pro 
465                 470                 475                 480 


Ser Asp Gln Arg Pro Tyr Cys Trp His Tyr Ala Pro Ser Pro Cys Gly 
                485                 490                 495     


Ile Val Pro Ala Lys Asp Val Cys Gly Pro Val Tyr Cys Phe Thr Pro 
            500                 505                 510         


Ser Pro Val Val Val Gly Thr Thr Asp Arg Arg Gly Val Pro Thr Tyr 
        515                 520                 525             


Thr Trp Gly Glu Asn Glu Ser Asp Val Phe Leu Leu Asn Ser Thr Arg 
    530                 535                 540                 


Pro Pro Gln Gly Ser Trp Phe Gly Cys Ser Trp Met Asn Thr Thr Gly 
545                 550                 555                 560 


Phe Thr Lys Thr Cys Gly Gly Pro Pro Cys Lys Ile Arg Pro Gln Gly 
                565                 570                 575     


Ala Gln Ser Asn Thr Ser Leu Thr Cys Pro Thr Asp Cys Phe Arg Lys 
            580                 585                 590         


His Pro Arg Ala Thr Tyr Ser Ala Cys Gly Ser Gly Pro Trp Leu Thr 
        595                 600                 605             


Pro Arg Cys Met Val His Tyr Pro Tyr Arg Leu Trp His Tyr Pro Cys 
    610                 615                 620                 


Thr Val Asn Phe Thr Ile His Lys Val Arg Leu Tyr Ile Gly Gly Val 
625                 630                 635                 640 


Glu His Arg Leu Asp Ala Ala Cys Asn Trp Thr Arg Gly Glu Arg Cys 
                645                 650                 655     


Asp Leu Glu Asp Arg Asp Arg Val Asp Met Ser Pro Leu Leu His Ser 
            660                 665                 670         


Thr Thr Glu Leu Ala Ile Leu Pro Cys Ser Phe Val Pro Leu Pro Ala 
        675                 680                 685             


Leu Ser Thr Gly Leu Ile His Leu His Gln Asn Ile Val Asp Ala Gln 
    690                 695                 700                 


Tyr Leu Tyr Gly Leu Ser Pro Ala Ile Ile Ser Trp Ala Ile Arg Trp 
705                 710                 715                 720 


Glu Trp Val Val Leu Val Phe Leu Leu Leu Ala Asp Ala Arg Ile Cys 
                725                 730                 735     


Ala Cys Leu Trp Met Met Met Leu Met Ala Gln Ala Glu Ala Ala Leu 
            740                 745                 750         


Glu Asn Leu Ile His Leu Asn Ala Ala Ser Leu Ala Gly Thr His Gly 
        755                 760                 765             


Ile Trp Trp Leu Leu Leu Val Phe Cys Ala Ser Trp His Leu Arg Gly 
    770                 775                 780                 


Arg Val Val Pro Leu Val Thr Tyr Gly Ile Cys Gly Met Trp Pro Phe 
785                 790                 795                 800 


Phe Leu Met Leu Leu Ser Leu Pro Pro Arg Ala Tyr Ala Leu Asp Arg 
                805                 810                 815     


Glu Val Ser Ala Ala Leu Gly Thr Gly Met Leu Ala Ile Ile Leu Leu 
            820                 825                 830         


Val Thr Leu Gly Pro His Tyr Lys Arg Leu Leu Ala Leu Ile Leu Trp 
        835                 840                 845             


Trp Val Thr Tyr Phe Leu Thr Arg Cys Glu Ala Ala Leu Gln Thr Trp 
    850                 855                 860                 


Val Pro Pro Leu Asn Pro Arg Gly Gly Arg Asp Gly Phe Ile Leu Cys 
865                 870                 875                 880 


Val Leu Leu Cys Tyr Pro Gly Leu Val Phe Asp Ile Thr Lys Trp Leu 
                885                 890                 895     


Leu Val Met Met Cys Pro Leu Tyr Leu Leu Gln Leu Cys Leu Val Arg 
            900                 905                 910         


Thr Pro Tyr Phe Val Arg Ala Gln Ala Leu Ile Arg Val Cys Ser Leu 
        915                 920                 925             


Phe Lys Thr Leu Ala Gly Gly Arg Tyr Val Gln Ala Ala Leu Leu Thr 
    930                 935                 940                 


Ile Gly Arg Trp Thr Gly Thr Tyr Ile Tyr Asn His Leu Ala Pro Leu 
945                 950                 955                 960 


Glu Thr Trp Ala Ala Gly Gly Leu Arg Asp Leu Ala Val Ala Val Glu 
                965                 970                 975     


Pro Val Ile Phe Ser Pro Met Glu Lys Lys Ile Ile Val Trp Gly Ala 
            980                 985                 990         


Glu Thr Thr Ala Cys Gly Asp Ile  Leu Cys Gly Leu Pro  Val Ser Ala 
        995                 1000                 1005             


Arg Leu  Gly Arg Glu Val Leu  Leu Gly Pro Ala Asp  Asp Tyr Arg 
    1010                 1015                 1020             


Ser Met  Gly Trp Gln Leu Leu  Ala Pro Ile Ser Ala  Tyr Ala Gln 
    1025                 1030                 1035             


Gln Thr  Arg Gly Leu Ile Ser  Thr Leu Val Val Ser  Leu Thr Gly 
    1040                 1045                 1050             


Arg Asp  Lys Asn Glu Thr Ala  Gly Glu Val Gln Val  Leu Ser Thr 
    1055                 1060                 1065             


Ser Thr  Gln Thr Phe Leu Gly  Thr Asn Val Gly Gly  Val Met Trp 
    1070                 1075                 1080             


Gly Pro  Tyr His Gly Ala Gly  Thr Arg Thr Val Ala  Gly Arg Gly 
    1085                 1090                 1095             


Gly Pro  Val Leu Gln Met Tyr  Thr Ser Val Ser Asp  Asp Leu Val 
    1100                 1105                 1110             


Gly Trp  Pro Ala Pro Pro Gly  Ser Lys Ser Leu Glu  Pro Cys Ser 
    1115                 1120                 1125             


Cys Gly  Ser Ala Asp Leu Tyr  Leu Val Thr Arg Asn  Ala Asp Val 
    1130                 1135                 1140             


Leu Pro  Leu Arg Arg Lys Gly  Asp Gly Thr Ala Ser  Leu Leu Ser 
    1145                 1150                 1155             


Pro Arg  Pro Val Ser Ser Leu  Lys Gly Ser Ser Gly  Gly Pro Val 
    1160                 1165                 1170             


Leu Cys  Pro Gln Ser His Cys  Val Gly Ile Phe Arg  Ala Ala Val 
    1175                 1180                 1185             


Cys Thr  Arg Gly Val Ala Lys  Ala Val Gln Phe Val  Pro Ile Glu 
    1190                 1195                 1200             


Lys Met  Gln Val Ala Gln Arg  Ser Pro Ser Phe Ser  Asp Asn Ser 
    1205                 1210                 1215             


Thr Pro  Pro Ala Val Pro Ser  Thr Tyr Gln Val Gly  Tyr Leu His 
    1220                 1225                 1230             


Ala Pro  Thr Gly Ser Gly Lys  Ser Thr Lys Val Pro  Ala Ala Tyr 
    1235                 1240                 1245             


Ala Ser  Gln Gly Tyr Lys Val  Leu Val Leu Asn Pro  Ser Val Ala 
    1250                 1255                 1260             


Ala Thr  Leu Gly Phe Gly Ala  Tyr Met Ser Lys Ala  Tyr Gly Ile 
    1265                 1270                 1275             


Asp Pro  Ser Val Arg Thr Gly  Ala Arg Thr Val Thr  Thr Gly Ala 
    1280                 1285                 1290             


Pro Ile  Thr Tyr Ser Thr Tyr  Gly Lys Phe Leu Ala  Asp Gly Gly 
    1295                 1300                 1305             


Cys Ser  Gly Gly Ala Tyr Asp  Ile Ile Ile Cys Asp  Glu Cys His 
    1310                 1315                 1320             


Ala Ile  Asp Ala Thr Thr Val  Val Gly Ile Gly Thr  Val Leu Asp 
    1325                 1330                 1335             


Gln Ala  Glu Thr Ser Gly Val  Arg Leu Val Val Leu  Ala Thr Ala 
    1340                 1345                 1350             


Thr Pro  Pro Gly Ser Val Thr  Val Pro His Pro Asn  Ile Glu Glu 
    1355                 1360                 1365             


Val Ala  Leu Gly Asn Asp Gly  Glu Ile Pro Phe Tyr  Gly Lys Ala 
    1370                 1375                 1380             


Ile Pro  Leu Gln His Ile Lys  Gly Gly Arg His Leu  Ile Phe Cys 
    1385                 1390                 1395             


His Ser  Lys Lys Lys Cys Asp  Glu Leu Ala Gly Lys  Leu Thr Ser 
    1400                 1405                 1410             


Leu Gly  Leu Thr Ala Val Ala  Tyr Tyr Arg Gly Leu  Asp Val Ser 
    1415                 1420                 1425             


Val Ile  Pro Thr Ser Gly Asp  Val Val Val Val Ala  Thr Asp Ala 
    1430                 1435                 1440             


Leu Met  Thr Gly Phe Thr Gly  Asp Phe Asp Ser Val  Ile Asp Cys 
    1445                 1450                 1455             


Asn Val  Ala Val Thr Gln Thr  Val Asp Phe Ser Leu  Asp Pro Thr 
    1460                 1465                 1470             


Phe Thr  Ile Glu Thr Thr Thr  Val Pro Gln Asp Ser  Val Ser Arg 
    1475                 1480                 1485             


Ser Gln  Arg Arg Gly Arg Thr  Gly Arg Gly Arg Leu  Gly Ile Tyr 
    1490                 1495                 1500             


Arg Tyr  Val Ser Ser Gly Glu  Arg Pro Ser Gly Met  Phe Asp Thr 
    1505                 1510                 1515             


Ser Val  Leu Cys Glu Cys Tyr  Asp Leu Gly Cys Ser  Trp Tyr Glu 
    1520                 1525                 1530             


Leu Thr  Pro Ser Glu Thr Thr  Thr Arg Leu Arg Ala  Tyr Leu Asn 
    1535                 1540                 1545             


Cys Pro  Gly Leu Pro Val Cys  Gln Asp His Leu Glu  Phe Trp Glu 
    1550                 1555                 1560             


Gly Val  Phe Thr Gly Leu Thr  His Ile Asp Ala His  Phe Leu Ser 
    1565                 1570                 1575             


Gln Thr  Lys Gln Glu Gly Gln  Asn Tyr Ala Tyr Leu  Thr Ala Tyr 
    1580                 1585                 1590             


Gln Ala  Thr Val Cys Ala Arg  Ala Lys Ala Pro Pro  Pro Ser Trp 
    1595                 1600                 1605             


Asp Val  Gln Trp Lys Cys Leu  Gln Arg Leu Lys Pro  Leu Leu Val 
    1610                 1615                 1620             


Gly Pro  Thr Pro Leu Leu Tyr  Arg Leu Gly Ser Val  Thr Asn Glu 
    1625                 1630                 1635             


Val Thr  Phe Thr His Pro Ile  Thr Lys Tyr Ile Ala  Thr Cys Met 
    1640                 1645                 1650             


Ala Ala  Asp Leu Glu Val Thr  Thr Ser Thr Trp Val  Ile Val Gly 
    1655                 1660                 1665             


Gly Val  Leu Ala Ala Val Ala  Ala Tyr Cys Met Ser  Thr Gly Ser 
    1670                 1675                 1680             


Val Val  Val Val Gly Arg Val  Val Leu Gly Ser Asn  Val Val Thr 
    1685                 1690                 1695             


Ala Pro  Asp Arg Glu Val Leu  Tyr Gln His Phe Asp  Glu Met Glu 
    1700                 1705                 1710             


Glu Cys  Ser Lys Ala Pro Glu  Leu Leu Lys His Ala  Gln Thr Ile 
    1715                 1720                 1725             


Gly Gly  Met Phe Lys Asp Lys  Ala Leu Ala Val Leu  Asp Thr Leu 
    1730                 1735                 1740             


Lys Pro  Ala Ala Gln Ala Ala  Val Pro Ile Val Glu  Thr Asn Phe 
    1745                 1750                 1755             


Gln Lys  Val Glu Lys Leu Trp  Asn Gln His Met Trp  Asn Phe Ile 
    1760                 1765                 1770             


Ser Gly  Ile Gln Tyr Leu Ala  Gly Leu Ser Thr Leu  Pro Gly Asn 
    1775                 1780                 1785             


Pro Thr  Val Ala Ser Leu Met  Ala Phe Thr Ala Ser  Val Thr Ser 
    1790                 1795                 1800             


Pro Leu  Ala Thr Ser Thr Thr  Leu Leu Val Asn Ile  Leu Gly Gly 
    1805                 1810                 1815             


Trp Phe  Ala Ser Gln Leu Ala  Pro Pro Ser Ala Ala  Thr Thr Phe 
    1820                 1825                 1830             


Val Val  Ser Gly Leu Ala Gly  Ala Ala Val Gly Ser  Val Gly Leu 
    1835                 1840                 1845             


Gly Lys  Val Leu Val Asp Val  Leu Ala Gly Tyr Gly  Ala Gly Ile 
    1850                 1855                 1860             


Ala Gly  Ala Leu Val Ala Phe  Lys Ile Met Ser Gly  Glu Val Pro 
    1865                 1870                 1875             


Ser Thr  Glu Asp Leu Ala Asn  Leu Leu Pro Ala Ile  Leu Ser Pro 
    1880                 1885                 1890             


Gly Ala  Leu Val Val Gly Val  Val Cys Ala Ala Ile  Ile Lys Arg 
    1895                 1900                 1905             


His Thr  Gly Thr Ser Glu Gly  Val Thr Gln Trp Met  Asn Arg Leu 
    1910                 1915                 1920             


Ile Ala  Phe Ala Ser Arg Gly  Asn His Val Ser Pro  Thr His Tyr 
    1925                 1930                 1935             


Ile Gln  Asp Asp Asp Ala Ser  Lys Arg Val Met Gly  Ile Leu Ser 
    1940                 1945                 1950             


Ser Leu  Thr Ile Thr Ser Leu  Ile Lys Arg Val Leu  Ala Trp Ala 
    1955                 1960                 1965             


Gln Thr  Asp Tyr Ser Ala Pro  Cys Ala Gly Ser Trp  Leu Arg Glu 
    1970                 1975                 1980             


Val Trp  Asp Trp Val Cys Met  Val Leu Ser Asp Phe  Ala Ser Trp 
    1985                 1990                 1995             


Leu Lys  Ala Lys Val Leu Pro  Ser Leu Pro Gly Ile  Pro Phe Leu 
    2000                 2005                 2010             


Ser Cys  Gln Lys Gly Tyr Lys  Gly Glu Trp Arg Asn  Asp Gly Ile 
    2015                 2020                 2025             


Met Asn  Thr Lys Cys Pro Cys  Gly Ala Leu Ile Ala  Gly His Val 
    2030                 2035                 2040             


Lys Asn  Gly Ser Met Arg Ile  Val Gly Pro Lys Thr  Cys Arg Asn 
    2045                 2050                 2055             


Thr Trp  Trp Gly Thr Phe Pro  Ile Asn Ser His Thr  Thr Gly Pro 
    2060                 2065                 2070             


Ser Ser  Pro Val Pro Ser His  Cys Tyr Gln Arg Ala  Leu Trp Arg 
    2075                 2080                 2085             


Val Ser  Ala Thr Glu Tyr Val  Glu Ile Leu Arg His  Asn Asp Gln 
    2090                 2095                 2100             


His Tyr  Val Val Gly Val Thr  Ala Glu Asp Leu Lys  Cys Pro Cys 
    2105                 2110                 2115             


Gln Val  Pro Ser Pro Glu Phe  Phe Ser Phe Val Asp  Gly Val Arg 
    2120                 2125                 2130             


Ile His  Arg Phe Ala Pro Glu  Pro Lys Pro Met Ile  Arg Glu Glu 
    2135                 2140                 2145             


Ala Ala  Phe Val Val Gly Leu  His Ser Tyr Val Val  Gly Ser Gln 
    2150                 2155                 2160             


Leu Pro  Cys Glu Pro Glu Pro  Asp Val Gln Thr Val  Ser Gln Leu 
    2165                 2170                 2175             


Leu Thr  Asp Pro Ser His Ile  Thr Ala Glu Thr Ala  Ala Arg Arg 
    2180                 2185                 2190             


Leu Arg  Arg Gly Ser Pro Pro  Ser Asn Ala Ser Ser  Ser Ala Ser 
    2195                 2200                 2205             


Gln Leu  Ser Ala Pro Ser Leu  Lys Ala Thr His Thr  Thr Leu Pro 
    2210                 2215                 2220             


Gln His  Pro Asp Ala Glu Leu  Ile Glu Ala Asn Leu  Met Trp Glu 
    2225                 2230                 2235             


His Lys  Val Gly Ala Ile Arg  Arg Met Glu Thr Asp  Thr Lys Val 
    2240                 2245                 2250             


Ile Ile  Leu Asp Ser Phe Asp  Ser Ala Ser Ser Val  Glu Asp Asp 
    2255                 2260                 2265             


Met Glu  Pro Ser Thr Ala Ala  Glu Cys Leu Arg Thr  Arg Lys Val 
    2270                 2275                 2280             


Phe Pro  Pro Ala Met Pro Ile  Trp Ala Arg Pro Asp  Tyr Asn Pro 
    2285                 2290                 2295             


Pro Val  Val Glu Asn Trp Lys  Asp Pro Glu Tyr Ala  Pro Pro Gln 
    2300                 2305                 2310             


Val Ser  Gly Cys Ala Leu Pro  Pro Ala Gln Thr Pro  Pro Val Pro 
    2315                 2320                 2325             


Pro Pro  Arg Arg Lys Arg Ala  Val Ile Gln Leu Thr  Glu Ser Ala 
    2330                 2335                 2340             


Val Ser  Thr Ala Leu Ala Glu  Leu Ala Glu Arg Ser  Phe Pro Lys 
    2345                 2350                 2355             


Glu Glu  Ala Pro Pro Ser Asp  Ser Ala Ile Ser Leu  Asp Ser Pro 
    2360                 2365                 2370             


Ala Ala  Asn Asp Pro Pro Ser  Asp Cys Asp Gln Gly  Ser Glu Ile 
    2375                 2380                 2385             


Ser Phe  Ser Ser Met Pro Pro  Leu Glu Gly Glu Pro  Gly Asp Pro 
    2390                 2395                 2400             


Asp Leu  Ser Asp Gly Ser Trp  Ser Thr Val Ser Thr  Arg Ser Asp 
    2405                 2410                 2415             


Val Ile  Cys Cys Ser Met Ser  Tyr Ser Trp Thr Gly  Ala Leu Val 
    2420                 2425                 2430             


Thr Pro  Ser Gly Pro Glu Glu  Glu Arg Leu Pro Ile  Asn Ala Leu 
    2435                 2440                 2445             


Ser Asn  Thr Met Leu Arg His  Tyr Asn Met Val Tyr  Ser Thr Thr 
    2450                 2455                 2460             


Ser Arg  Ser Ala Ser Gln Arg  Ala Lys Lys Val Thr  Phe Asp Arg 
    2465                 2470                 2475             


Leu Gln  Val Leu Asp Asp His  Tyr Lys Arg Ala Leu  Ala Asp Val 
    2480                 2485                 2490             


Lys Ala  Asp Ala Ser Thr Val  Lys Ala Gln Leu Leu  Ser Val Glu 
    2495                 2500                 2505             


Glu Ala  Ala Ala Leu Thr Pro  Ala His Ser Ala Arg  Ser Lys Phe 
    2510                 2515                 2520             


Gly Tyr  Gly Ala Lys Glu Val  Arg Ser Leu Ala Pro  Lys Ala Met 
    2525                 2530                 2535             


Ser His  Ile Lys Glu Val Trp  Lys Asp Leu Leu Gln  Asp Met Thr 
    2540                 2545                 2550             


Thr Pro  Ile Pro Thr Thr Ile  Met Ala Lys Asn Glu  Val Phe Cys 
    2555                 2560                 2565             


Val Asn  Pro Ala Lys Gly Gly  Lys Lys Pro Ala Arg  Leu Ile Val 
    2570                 2575                 2580             


Tyr Pro  Asp Leu Gly Val Arg  Val Cys Glu Lys Arg  Ala Leu Tyr 
    2585                 2590                 2595             


Asp Ile  Ala Gln Lys Leu Pro  Lys Ala Ile Met Gly  Gln Ala Tyr 
    2600                 2605                 2610             


Gly Phe  Gln Tyr Ser Pro Ser  Gln Arg Val Glu Tyr  Leu Val Lys 
    2615                 2620                 2625             


Thr Trp  Lys Ser Lys Arg Thr  Pro Met Gly Phe Ser  Tyr Asp Thr 
    2630                 2635                 2640             


Arg Cys  Phe Asp Ser Thr Val  Thr Glu Gln Asp Ile  Arg Thr Glu 
    2645                 2650                 2655             


Ser Glu  Ile Tyr Gln Cys Cys  Asn Leu Asp Pro Glu  Ala Arg Thr 
    2660                 2665                 2670             


Ile Ile  Asn Ala Leu Thr Glu  Arg Leu Tyr Val Gly  Gly Pro Met 
    2675                 2680                 2685             


Phe Asn  Ser Lys Gly Gln Arg  Val Gly Tyr Arg Arg  Cys Arg Ala 
    2690                 2695                 2700             


Ser Gly  Val Phe Pro Thr Ser  Met Gly Asn Thr Met  Thr Cys Tyr 
    2705                 2710                 2715             


Ile Lys  Ala Lys Ala Ala Ala  Ala Ala Ala Gly Leu  Glu Ser Thr 
    2720                 2725                 2730             


Asp Phe  Leu Val Cys Gly Asp  Asp Leu Val Val Ile  Cys Glu Ser 
    2735                 2740                 2745             


Lys Gly  Val Glu Arg Asp Arg  Ala Asp Leu Gln Ala  Phe Ala Ala 
    2750                 2755                 2760             


Ala Met  Thr Arg Tyr Ser Ala  Pro Pro Gly Asp Met  Pro Gln Pro 
    2765                 2770                 2775             


Ala Tyr  Asp Leu Glu His Ile  Asp Ser Cys Ser Ser  Asn Val Ser 
    2780                 2785                 2790             


Val Ala  Arg Asp Asn Ser Gly  Lys Arg Val Tyr Tyr  Leu Thr Arg 
    2795                 2800                 2805             


Asp Pro  Thr Asn Pro Leu Ser  Arg Ala Ala Trp Glu  Thr Ala Arg 
    2810                 2815                 2820             


His Ser  Pro Val Asn Ser Trp  Val Gly Asn Ile Ile  Met Phe Ala 
    2825                 2830                 2835             


Pro Thr  Ile Trp Val Arg Met  Val Leu Met Thr His  Phe Phe Ala 
    2840                 2845                 2850             


Leu Leu  Leu Asn Glu Glu Arg  Leu Asn Asp Pro Val  Ser Phe Glu 
    2855                 2860                 2865             


Met Tyr  Gly Ala Thr Tyr Thr  Val Cys Pro Thr Asp  Leu Pro Asp 
    2870                 2875                 2880             


Ile Ile  Gln Arg Leu His Gly  Leu Arg Ala Phe Glu  Leu His Thr 
    2885                 2890                 2895             


Tyr Ser  Pro Ala Glu Leu Thr  Arg Val Ala Ala Thr  Leu Arg Lys 
    2900                 2905                 2910             


Leu Gly  Val Pro Pro Leu Arg  Thr Trp Arg Gln Arg  Ala Arg Lys 
    2915                 2920                 2925             


Val Arg  Ala Gly Leu Ile Gly  Gln Gly Gly Arg Ala  Arg Ile Cys 
    2930                 2935                 2940             


Gly Leu  Tyr Leu Phe Asn Trp  Ala Val Arg Thr Lys  Ile Lys Leu 
    2945                 2950                 2955             


Thr Pro  Leu Ala Gly Ala Gly  Arg Leu Asp Leu Ser  Ser Trp Phe 
    2960                 2965                 2970             


Ser Val  Cys Ala Gly Glu Ala  Asp Val Asp His Ser  Thr Pro Arg 
    2975                 2980                 2985             


Ala His  Pro Arg Pro Leu Leu  Leu Cys Leu Leu Leu  Leu Ala Val 
    2990                 2995                 3000             


Gly Val  Gly Ile Phe Leu Leu  Pro Ala Arg 
    3005                 3010             


<210>  106
<211>  3008
<212>  PRT
<213>  hepatitis C virus


<220>
<221>  misc_feature
<222>  (1871)..(1871)
<223>  Xaa can be any amino acid

<400>  106

Met Ser Thr Asn Pro Lys Pro Gln Arg Lys Thr Lys Arg Asn Thr Asn 
1               5                   10                  15      


Arg Arg Pro Gln Asp Val Lys Phe Pro Gly Gly Gly Gln Ile Val Gly 
            20                  25                  30          


Gly Val Tyr Leu Leu Pro Arg Arg Gly Pro Arg Leu Gly Val Arg Ala 
        35                  40                  45              


Thr Arg Lys Thr Ser Glu Arg Ser Gln Pro Arg Gly Arg Arg Gln Pro 
    50                  55                  60                  


Ile Pro Lys Ala Arg Arg Pro Glu Gly Arg Thr Trp Ala Gln Pro Gly 
65                  70                  75                  80  


Tyr Pro Trp Pro Leu Tyr Gly Asn Glu Gly Cys Gly Trp Ala Gly Trp 
                85                  90                  95      


Leu Leu Ser Pro Arg Gly Ser Arg Pro Ser Trp Gly Pro Thr Asp Pro 
            100                 105                 110         


Arg Arg Arg Ser Arg Asn Leu Gly Lys Val Ile Asp Thr Leu Thr Cys 
        115                 120                 125             


Gly Phe Ala Asp Leu Met Gly Tyr Ile Pro Leu Val Gly Ala Pro Leu 
    130                 135                 140                 


Gly Gly Ala Ala Arg Ala Leu Ala His Gly Val Arg Val Leu Glu Asp 
145                 150                 155                 160 


Gly Val Asn Tyr Ala Thr Gly Asn Leu Pro Gly Cys Ser Phe Ser Ile 
                165                 170                 175     


Phe Leu Leu Ala Leu Leu Ser Cys Leu Thr Val Pro Ala Ser Ala Tyr 
            180                 185                 190         


Gln Val Arg Asn Ser Thr Gly Leu Tyr His Val Thr Asn Asp Cys Pro 
        195                 200                 205             


Asn Ser Ser Ile Val Tyr Glu Ala Ala Asp Ala Ile Leu His Thr Pro 
    210                 215                 220                 


Gly Cys Val Pro Cys Val Arg Glu Gly Asn Thr Ser Arg Cys Trp Val 
225                 230                 235                 240 


Ala Met Thr Pro Thr Val Ala Thr Arg Asp Gly Lys Leu Pro Thr Thr 
                245                 250                 255     


Gln Leu Arg Arg His Ile Asp Leu Leu Val Gly Ser Ala Thr Leu Cys 
            260                 265                 270         


Ser Ala Leu Tyr Val Gly Asp Leu Cys Gly Ser Val Phe Leu Val Gly 
        275                 280                 285             


Gln Met Phe Thr Phe Ser Pro Arg Arg His Trp Thr Thr Gln Asp Cys 
    290                 295                 300                 


Asn Cys Ser Leu Tyr Pro Gly His Ile Thr Gly His Arg Met Ala Trp 
305                 310                 315                 320 


Asp Met Met Met Asn Trp Ser Pro Thr Ala Ala Leu Ile Thr Ala Gln 
                325                 330                 335     


Leu Leu Arg Ile Pro Gln Ala Ile Leu Asp Met Ile Ala Gly Ala His 
            340                 345                 350         


Trp Gly Val Leu Ala Gly Ile Ala Tyr Phe Ser Met Val Gly Asn Trp 
        355                 360                 365             


Ala Lys Val Leu Val Val Leu Leu Leu Phe Ala Gly Val Asp Ala Gln 
    370                 375                 380                 


Thr His Val Thr Gly Gly Arg Ala Ala His Ile Thr Ala Gly Leu Thr 
385                 390                 395                 400 


Ser Leu Phe Ser Pro Gly Pro Ser Gln Lys Leu Gln Leu Val Asn Thr 
                405                 410                 415     


Asn Gly Ser Trp His Ile Asn Ser Thr Ala Leu Asn Cys Asn Asp Ser 
            420                 425                 430         


Leu Lys Thr Gly Trp Ile Ala Gly Leu Leu Tyr Ser Tyr Lys Phe Asn 
        435                 440                 445             


Ser Ser Gly Cys Pro Glu Arg Leu Ala Ser Cys Arg Arg Leu Thr Asp 
    450                 455                 460                 


Phe Ala Gln Gly Trp Gly Pro Ile Ser His Ala Asn Gly Ser Gly Pro 
465                 470                 475                 480 


Asp Glu Arg Pro Tyr Cys Trp His Tyr Pro Pro Arg Pro Cys Gly Ile 
                485                 490                 495     


Val Pro Ala Lys Ser Val Cys Gly Pro Val Tyr Cys Phe Thr Pro Ser 
            500                 505                 510         


Pro Val Val Val Gly Thr Thr Asp Lys Ser Gly Ala Pro Thr Tyr Asn 
        515                 520                 525             


Trp Gly Glu Asn Asp Trp Asp Val Phe Val Leu Asn Asn Thr Arg Pro 
    530                 535                 540                 


Pro Leu Gly Asn Trp Phe Gly Cys Thr Trp Met Asn Ser Thr Gly Phe 
545                 550                 555                 560 


Thr Lys Val Cys Gly Ala Pro Pro Cys Val Ile Gly Gly Ala Gly Asn 
                565                 570                 575     


Asn Thr Leu Arg Cys Pro Thr Asp Cys Phe Arg Lys His Pro Asp Ala 
            580                 585                 590         


Thr Tyr Ser Arg Cys Gly Ser Gly Pro Trp Ile Thr Pro Arg Cys Leu 
        595                 600                 605             


Val Asp Tyr Pro Tyr Arg Leu Trp His Tyr Pro Cys Thr Val Asn Tyr 
    610                 615                 620                 


Ser Ile Phe Lys Ile Arg Met Tyr Leu Gly Gly Val Glu His Arg Leu 
625                 630                 635                 640 


Glu Ala Ala Cys Asn Trp Thr Arg Gly Glu Arg Cys Asp Leu Glu Asp 
                645                 650                 655     


Arg Asp Arg Ser Glu Leu Ser Pro Leu Leu Leu Ser Thr Thr Gln Trp 
            660                 665                 670         


Gln Val Leu Pro Cys Ser Phe Thr Thr Leu Pro Ala Leu Ser Thr Gly 
        675                 680                 685             


Leu Ile His Leu His Gln Asn Ile Val Asp Val Gln Tyr Leu Tyr Gly 
    690                 695                 700                 


Val Gly Ser Ser Val Ala Ser Trp Ala Ile Lys Trp Asp Tyr Val Val 
705                 710                 715                 720 


Leu Leu Phe Leu Leu Leu Ala Asp Ala Arg Ile Cys Ser Cys Leu Trp 
                725                 730                 735     


Met Met Leu Leu Ile Ser Gln Ala Glu Ala Ala Leu Glu Asn Leu Val 
            740                 745                 750         


Val Leu Asn Ala Ala Ser Leu Ala Gly Thr His Gly Leu Ala Pro Phe 
        755                 760                 765             


Leu Val Phe Phe Cys Leu Ala Trp Tyr Leu Lys Gly Lys Trp Ala Pro 
    770                 775                 780                 


Gly Ala Val Tyr Ala Val Tyr Gly Met Trp Pro Leu Leu Leu Leu Leu 
785                 790                 795                 800 


Leu Ala Leu Pro Gln Arg Ala Tyr Ala Leu Asp Thr Glu Val Ala Ala 
                805                 810                 815     


Ser Cys Gly Gly Ala Val Leu Val Gly Leu Met Val Leu Thr Leu Ser 
            820                 825                 830         


Pro His Tyr Lys His Tyr Ile Ser Trp Cys Leu Trp Trp Leu Gln Tyr 
        835                 840                 845             


Phe Leu Thr Arg Ala Glu Ala Gln Leu His Val Trp Val Pro Pro Leu 
    850                 855                 860                 


Asn Val Arg Gly Gly Arg Asp Ala Val Ile Leu Leu Met Cys Val Val 
865                 870                 875                 880 


His Pro Thr Leu Val Phe Asp Ile Thr Lys Leu Leu Leu Ala Val Gly 
                885                 890                 895     


Pro Leu Trp Ile Leu Gln Thr Ser Leu Leu Lys Val Pro Tyr Phe Val 
            900                 905                 910         


Arg Val Gln Gly Leu Leu Arg Ile Cys Ala Leu Ala Arg Lys Ile Ala 
        915                 920                 925             


Gly Gly His Tyr Val Gln Met Ala Ile Ile Lys Leu Gly Ala Leu Thr 
    930                 935                 940                 


Gly Thr Tyr Ile Tyr Asp His Leu Thr Pro Leu Arg Asp Trp Ala His 
945                 950                 955                 960 


Asn Gly Leu Arg Asp Leu Ala Val Ala Val Glu Pro Val Val Phe Ser 
                965                 970                 975     


Arg Met Glu Thr Lys Leu Ile Thr Trp Gly Ala Asp Thr Ala Ala Cys 
            980                 985                 990         


Gly Asp Ile Ile Asn Gly Leu Pro  Val Ser Ala Arg Arg  Gly Gln Glu 
        995                 1000                 1005             


Ile Leu  Leu Gly Pro Ala Asp  Gly Met Val Ser Lys  Gly Trp Arg 
    1010                 1015                 1020             


Leu Leu  Ala Pro Ile Thr Ala  Tyr Ala Gln Gln Thr  Arg Gly Leu 
    1025                 1030                 1035             


Leu Gly  Cys Ile Ile Thr Ser  Leu Thr Gly Arg Asp  Lys Asn Gln 
    1040                 1045                 1050             


Val Glu  Gly Glu Val Gln Ile  Val Ser Thr Ala Ala  Gln Thr Phe 
    1055                 1060                 1065             


Leu Ala  Thr Cys Ile Asn Gly  Val Cys Trp Thr Val  Tyr His Gly 
    1070                 1075                 1080             


Ala Gly  Thr Arg Thr Ile Ala  Ser Pro Lys Gly Pro  Val Ile Gln 
    1085                 1090                 1095             


Met Tyr  Thr Asn Val Asp Lys  Asp Leu Val Gly Trp  Pro Ala Pro 
    1100                 1105                 1110             


Pro Gly  Ser Arg Ser Leu Thr  Pro Cys Thr Cys Gly  Ser Ser Asp 
    1115                 1120                 1125             


Leu Tyr  Leu Val Thr Arg His  Ala Asp Val Ile Pro  Val Arg Arg 
    1130                 1135                 1140             


Arg Gly  Asp Ser Arg Gly Ser  Leu Leu Ser Pro Arg  Pro Ile Ser 
    1145                 1150                 1155             


Tyr Leu  Lys Gly Ser Ser Gly  Gly Pro Leu Leu Cys  Pro Ala Gly 
    1160                 1165                 1170             


His Ala  Val Gly Ile Phe Arg  Ala Ala Val Cys Thr  Arg Gly Val 
    1175                 1180                 1185             


Ala Lys  Ala Val Asp Phe Ile  Pro Val Glu Ser Leu  Glu Thr Thr 
    1190                 1195                 1200             


Met Arg  Ser Pro Val Phe Thr  Asp Asn Ser Ser Pro  Pro Val Val 
    1205                 1210                 1215             


Pro Gln  Ser Phe Gln Val Ala  His Leu His Ala Pro  Thr Gly Ser 
    1220                 1225                 1230             


Gly Lys  Ser Thr Lys Val Pro  Ala Ala Tyr Ala Ala  Gln Gly Tyr 
    1235                 1240                 1245             


Lys Val  Leu Val Leu Asn Pro  Ser Val Ala Ala Thr  Leu Phe Gly 
    1250                 1255                 1260             


Ala Tyr  Met Ser Lys Ala His  Gly Val Asp Pro Asn  Ile Arg Thr 
    1265                 1270                 1275             


Gly Val  Arg Thr Ile Thr Thr  Gly Ser Pro Ile Thr  Tyr Ser Thr 
    1280                 1285                 1290             


Tyr Gly  Lys Phe Leu Ala Asp  Gly Gly Cys Ser Gly  Gly Ala Tyr 
    1295                 1300                 1305             


Asp Ile  Ile Ile Cys Asp Glu  Cys His Ser Thr Asp  Ala Thr Ser 
    1310                 1315                 1320             


Ile Leu  Gly Ile Gly Thr Val  Leu Asp Gln Ala Glu  Thr Ala Gly 
    1325                 1330                 1335             


Ala Arg  Leu Val Val Leu Ala  Thr Ala Thr Pro Pro  Gly Ser Val 
    1340                 1345                 1350             


Thr Val  Pro His Pro Asn Ile  Glu Glu Val Ala Leu  Ser Thr Thr 
    1355                 1360                 1365             


Gly Glu  Ile Pro Phe Tyr Gly  Lys Ala Ile Pro Leu  Glu Val Ile 
    1370                 1375                 1380             


Lys Gly  Gly Arg His Leu Ile  Phe Cys His Ser Lys  Lys Lys Cys 
    1385                 1390                 1395             


Asp Glu  Leu Ala Ala Lys Leu  Val Ala Leu Gly Ile  Asn Ala Val 
    1400                 1405                 1410             


Ala Tyr  Tyr Arg Gly Leu Asp  Val Ser Val Ile Pro  Thr Ser Gly 
    1415                 1420                 1425             


Asp Val  Val Val Val Ala Thr  Asp Ala Leu Met Thr  Gly Tyr Thr 
    1430                 1435                 1440             


Gly Asp  Phe Asp Ser Val Ile  Asp Cys Asn Thr Cys  Val Thr Gln 
    1445                 1450                 1455             


Thr Val  Asp Phe Ser Leu Asp  Pro Thr Phe Thr Ile  Glu Thr Thr 
    1460                 1465                 1470             


Thr Leu  Pro Gln Asp Ala Val  Ser Arg Thr Gln Arg  Arg Gly Arg 
    1475                 1480                 1485             


Thr Gly  Arg Gly Lys Pro Gly  Ile Tyr Arg Phe Val  Ala Pro Gly 
    1490                 1495                 1500             


Glu Arg  Pro Ser Gly Met Phe  Asp Ser Ser Val Leu  Cys Glu Cys 
    1505                 1510                 1515             


Tyr Asp  Ala Gly Cys Ala Trp  Tyr Glu Leu Thr Pro  Ala Glu Thr 
    1520                 1525                 1530             


Thr Val  Arg Leu Arg Ala Tyr  Met Asn Thr Pro Gly  Leu Pro Val 
    1535                 1540                 1545             


Cys Gln  Asp His Leu Glu Phe  Trp Glu Gly Val Phe  Thr Gly Leu 
    1550                 1555                 1560             


Thr His  Ile Asp Ala His Phe  Leu Ser Gln Thr Lys  Gln Ser Gly 
    1565                 1570                 1575             


Glu Asn  Phe Pro Tyr Leu Val  Ala Tyr Gln Ala Thr  Val Cys Ala 
    1580                 1585                 1590             


Arg Ala  Gln Ala Pro Pro Pro  Ser Trp Asp Gln Met  Trp Lys Cys 
    1595                 1600                 1605             


Leu Ile  Arg Leu Lys Pro Thr  Leu His Gly Pro Thr  Pro Leu Leu 
    1610                 1615                 1620             


Tyr Arg  Leu Gly Ala Val Gln  Asn Glu Val Val Leu  Thr His Pro 
    1625                 1630                 1635             


Ile Thr  Lys Tyr Ile Met Thr  Cys Met Ser Ala Asp  Leu Glu Val 
    1640                 1645                 1650             


Val Thr  Ser Thr Trp Val Leu  Val Gly Gly Val Leu  Ala Ala Leu 
    1655                 1660                 1665             


Ala Ala  Tyr Cys Leu Ser Thr  Gly Cys Val Val Ile  Val Gly Arg 
    1670                 1675                 1680             


Val Val  Leu Ser Gly Lys Pro  Ala Ile Ile Pro Asp  Arg Glu Val 
    1685                 1690                 1695             


Leu Tyr  Gln Glu Phe Asp Glu  Met Glu Glu Cys Ser  Gln His Leu 
    1700                 1705                 1710             


Pro Tyr  Ile Glu Gln Gly Met  Met Leu Ala Glu Gln  Phe Lys Gln 
    1715                 1720                 1725             


Lys Ala  Leu Gly Leu Leu Gln  Thr Ala Ser Arg Gln  Ala Glu Val 
    1730                 1735                 1740             


Ile Ala  Pro Ala Val Gln Thr  Asn Trp Gln Lys Leu  Glu Ala Phe 
    1745                 1750                 1755             


Trp Ala  Lys His Met Trp Asn  Phe Ile Ser Gly Ile  Gln Tyr Leu 
    1760                 1765                 1770             


Ala Gly  Leu Ser Thr Leu Pro  Gly Thr Pro Ala Ile  Ala Ser Leu 
    1775                 1780                 1785             


Met Ala  Phe Thr Ala Ala Val  Thr Ser Pro Leu Thr  Thr Ser Gln 
    1790                 1795                 1800             


Thr Leu  Leu Phe Asn Ile Leu  Gly Gly Trp Val Ala  Ala Gln Leu 
    1805                 1810                 1815             


Ala Ala  Pro Gly Ala Ala Thr  Ala Phe Val Gly Ala  Gly Leu Ala 
    1820                 1825                 1830             


Gly Ala  Ala Ile Gly Ser Val  Gly Leu Gly Lys Val  Leu Val Asp 
    1835                 1840                 1845             


Ile Leu  Ala Gly Tyr Gly Ala  Gly Val Ala Gly Ala  Leu Val Ala 
    1850                 1855                 1860             


Phe Lys  Ile Met Ser Gly Glu  Xaa Pro Ser Thr Glu  Asp Leu Val 
    1865                 1870                 1875             


Asn Leu  Leu Pro Ala Ile Leu  Ser Pro Gly Ala Leu  Val Val Gly 
    1880                 1885                 1890             


Val Val  Cys Ala Ala Ile Leu  Arg Arg His Val Gly  Pro Gly Glu 
    1895                 1900                 1905             


Gly Ala  Val Gln Trp Met Asn  Arg Leu Ile Ala Phe  Ala Ser Arg 
    1910                 1915                 1920             


Gly Asn  His Val Ser Pro Thr  His Tyr Val Pro Glu  Ser Asp Ala 
    1925                 1930                 1935             


Ala Ala  Arg Val Thr Ala Ile  Leu Ser Ser Leu Thr  Val Thr Gln 
    1940                 1945                 1950             


Leu Leu  Arg Arg Leu His Gln  Trp Ile Ser Ser Glu  Cys Thr Thr 
    1955                 1960                 1965             


Pro Cys  Ser Gly Ser Trp Leu  Arg Asp Ile Trp Asp  Trp Ile Cys 
    1970                 1975                 1980             


Glu Val  Leu Ser Asp Phe Lys  Thr Trp Leu Lys Ala  Lys Leu Met 
    1985                 1990                 1995             


Pro Gln  Leu Pro Gly Ile Pro  Phe Val Ser Cys Gln  Arg Gly Tyr 
    2000                 2005                 2010             


Arg Gly  Val Trp Arg Gly Asp  Gly Ile Met His Thr  Arg Cys His 
    2015                 2020                 2025             


Cys Gly  Ala Glu Ile Thr Gly  His Val Lys Asn Gly  Thr Met Arg 
    2030                 2035                 2040             


Ile Val  Gly Pro Arg Thr Cys  Arg Asn Met Trp Ser  Gly Thr Phe 
    2045                 2050                 2055             


Pro Ile  Asn Ala Tyr Thr Thr  Gly Pro Cys Thr Pro  Leu Pro Ala 
    2060                 2065                 2070             


Pro Asn  Tyr Lys Phe Ala Leu  Trp Arg Val Ser Ala  Glu Glu Tyr 
    2075                 2080                 2085             


Val Glu  Ile Arg Gln Val Gly  Asp Phe His Tyr Val  Thr Gly Met 
    2090                 2095                 2100             


Thr Thr  Asp Asp Leu Lys Cys  Pro Cys Gln Val Pro  Ser Pro Glu 
    2105                 2110                 2115             


Phe Phe  Thr Glu Leu Asp Gly  Val Arg Leu His Arg  Phe Ala Pro 
    2120                 2125                 2130             


Pro Cys  Lys Pro Leu Leu Arg  Glu Glu Val Ser Phe  Arg Val Gly 
    2135                 2140                 2145             


Leu His  Ala Tyr Pro Val Gly  Ser Gln Leu Pro Cys  Glu Pro Glu 
    2150                 2155                 2160             


Pro Asp  Val Ala Val Leu Thr  Ser Met Leu Thr Asp  Pro Ser His 
    2165                 2170                 2175             


Ile Thr  Ala Glu Thr Ala Arg  Arg Leu Ala Arg Gly  Ser Pro Pro 
    2180                 2185                 2190             


Ser Val  Ala Ser Ser Ser Ala  Ser Gln Leu Ser Ala  Pro Ser Leu 
    2195                 2200                 2205             


Lys Ala  Thr Cys Thr Ala Asn  His Asp Ser Pro Asp  Ala Glu Leu 
    2210                 2215                 2220             


Ile Glu  Ala Asn Leu Leu Trp  Arg Gln Glu Met Gly  Gly Asn Ile 
    2225                 2230                 2235             


Thr Arg  Val Glu Ser Glu Asn  Lys Val Val Ile Leu  Asp Ser Phe 
    2240                 2245                 2250             


Asp Pro  Leu Val Ala Glu Glu  Asp Glu Arg Glu Ile  Ser Val Pro 
    2255                 2260                 2265             


Ala Glu  Ile Leu Arg Lys Ser  Arg Arg Phe Thr Gln  Ala Leu Pro 
    2270                 2275                 2280             


Val Trp  Ala Arg Pro Asp Tyr  Asn Pro Pro Leu Val  Glu Ala Trp 
    2285                 2290                 2295             


Lys Lys  Pro Asp Tyr Glu Pro  Pro Val Val His Gly  Cys Pro Leu 
    2300                 2305                 2310             


Pro Pro  Pro Lys Ser Pro Pro  Val Pro Pro Pro Arg  Lys Lys Arg 
    2315                 2320                 2325             


Thr Val  Val Leu Thr Glu Ser  Thr Leu Ser Thr Ala  Leu Ala Glu 
    2330                 2335                 2340             


Leu Ala  Thr Lys Ser Phe Gly  Ser Ser Ser Thr Ser  Gly Ile Thr 
    2345                 2350                 2355             


Gly Asp  Asn Thr Thr Thr Ser  Ser Glu Pro Ala Pro  Pro Gly Cys 
    2360                 2365                 2370             


Ser Pro  Asp Ser Asp Ala Glu  Ser Cys Ser Ser Met  Pro Pro Leu 
    2375                 2380                 2385             


Glu Gly  Glu Pro Gly Asp Pro  Asp Leu Ser Asp Gly  Ser Trp Ser 
    2390                 2395                 2400             


Thr Val  Ser Ser Glu Ala Asp  Thr Glu Asp Val Val  Cys Cys Ser 
    2405                 2410                 2415             


Met Ser  Tyr Thr Trp Thr Gly  Ala Leu Ile Thr Pro  Cys Ala Ala 
    2420                 2425                 2430             


Glu Glu  Gln Lys Leu Pro Ile  Asn Ala Leu Ser Asn  Ser Leu Leu 
    2435                 2440                 2445             


Arg His  His Asn Leu Val Tyr  Ser Thr Thr Ser Arg  Ser Ala Cys 
    2450                 2455                 2460             


Gln Arg  Gln Lys Lys Val Thr  Phe Asp Arg Leu Gln  Val Leu Asp 
    2465                 2470                 2475             


Asn His  Tyr Gln Asp Val Leu  Lys Glu Val Lys Ala  Ala Ala Ser 
    2480                 2485                 2490             


Lys Val  Lys Ala Asn Leu Leu  Ser Val Glu Glu Ala  Cys Ser Leu 
    2495                 2500                 2505             


Thr Pro  Pro His Ser Ala Lys  Ser Lys Phe Gly Tyr  Gly Ala Lys 
    2510                 2515                 2520             


Asp Val  Arg Cys His Ala Arg  Lys Ala Val Asn His  Ile Asn Ser 
    2525                 2530                 2535             


Val Trp  Lys Asp Leu Leu Glu  Asp Ser Val Thr Pro  Ile Asp Thr 
    2540                 2545                 2550             


Thr Ile  Met Ala Lys Asn Glu  Val Phe Cys Val Gln  Pro Glu Lys 
    2555                 2560                 2565             


Gly Gly  Arg Lys Pro Ala Arg  Leu Ile Val Phe Pro  Asp Leu Gly 
    2570                 2575                 2580             


Val Arg  Val Cys Glu Lys Met  Ala Leu Tyr Asp Val  Val Ser Lys 
    2585                 2590                 2595             


Leu Pro  Leu Ala Val Met Gly  Asp Ser Tyr Gly Phe  Gln Tyr Ser 
    2600                 2605                 2610             


Pro Gly  Gln Arg Val Glu Phe  Leu Val Gln Ala Trp  Lys Ser Lys 
    2615                 2620                 2625             


Lys Thr  Pro Met Gly Phe Ser  Tyr Asp Thr Arg Cys  Phe Asp Ser 
    2630                 2635                 2640             


Thr Val  Thr Glu Ser Asp Ile  Arg Thr Glu Glu Ala  Ile Tyr Gln 
    2645                 2650                 2655             


Cys Cys  Asp Leu Asp Pro Gln  Ala Arg Val Ala Ile  Lys Ser Leu 
    2660                 2665                 2670             


Thr Glu  Arg Leu Tyr Val Gly  Gly Pro Leu Thr Asn  Ser Arg Gly 
    2675                 2680                 2685             


Glu Asn  Cys Gly Tyr Arg Arg  Cys Arg Ala Ser Gly  Val Leu Thr 
    2690                 2695                 2700             


Thr Ser  Cys Gly Asn Thr Leu  Thr Cys Tyr Ile Lys  Ala Lys Ala 
    2705                 2710                 2715             


Ala Cys  Arg Ala Ala Gly Leu  Gln Asn Cys Thr Met  Leu Val Cys 
    2720                 2725                 2730             


Gly Asp  Asp Leu Val Val Ile  Cys Glu Ser Ala Gly  Val Gln Glu 
    2735                 2740                 2745             


Asp Ala  Ala Ser Leu Arg Ala  Phe Thr Glu Ala Met  Thr Arg Tyr 
    2750                 2755                 2760             


Ser Ala  Pro Pro Gly Asp Pro  Pro Gln Pro Glu Tyr  Asp Leu Glu 
    2765                 2770                 2775             


Leu Ile  Thr Ser Cys Ser Ser  Asn Val Ser Val Ala  His Asp Gly 
    2780                 2785                 2790             


Ala Gly  Lys Arg Val Tyr Tyr  Leu Thr Arg Asp Pro  Thr Thr Pro 
    2795                 2800                 2805             


Leu Ala  Arg Ala Ala Trp Glu  Thr Ala Arg His Thr  Pro Val Asn 
    2810                 2815                 2820             


Ser Trp  Leu Gly Asn Ile Ile  Met Phe Ala Pro Thr  Leu Trp Ala 
    2825                 2830                 2835             


Arg Met  Val Leu Met Thr His  Phe Phe Ser Val Leu  Ile Ala Arg 
    2840                 2845                 2850             


Asp Gln  Leu Glu Gln Ala Leu  Asp Cys Glu Ile Tyr  Gly Ala Cys 
    2855                 2860                 2865             


Tyr Ser  Ile Glu Pro Leu Asp  Leu Pro Pro Ile Ile  Gln Arg Leu 
    2870                 2875                 2880             


His Gly  Leu Ser Ala Phe Ser  Leu His Ser Tyr Ser  Pro Gly Glu 
    2885                 2890                 2895             


Ile Asn  Arg Val Ala Ala Cys  Leu Arg Lys Leu Gly  Val Pro Pro 
    2900                 2905                 2910             


Leu Arg  Thr Trp Arg His Arg  Ala Arg Ser Val Arg  Ala Lys Leu 
    2915                 2920                 2925             


Leu Ser  Arg Gly Gly Arg Ala  Ala Ile Cys Gly Lys  Tyr Leu Phe 
    2930                 2935                 2940             


Asn Trp  Ala Val Arg Thr Lys  Leu Lys Leu Thr Pro  Ile Ala Ala 
    2945                 2950                 2955             


Ala Gly  Arg Leu Asp Leu Ser  Gly Trp Phe Thr Ala  Gly Tyr Ser 
    2960                 2965                 2970             


Gly Gly  Asp Ile Tyr His Ser  Val Ser His Ala Arg  Pro Arg Trp 
    2975                 2980                 2985             


Phe Trp  Phe Cys Leu Leu Leu  Leu Ala Ala Gly Val  Gly Ile Tyr 
    2990                 2995                 3000             


Leu Leu  Pro Asn Arg 
    3005             


<210>  107
<211>  3021
<212>  PRT
<213>  hepatitis C virus

<400>  107

Met Ser Thr Leu Pro Lys Pro Gln Arg Lys Thr Lys Arg Asn Thr Ile 
1               5                   10                  15      


Arg Arg Pro Gln Asp Val Lys Phe Pro Gly Gly Gly Gln Ile Val Gly 
            20                  25                  30          


Gly Val Tyr Val Leu Pro Arg Arg Gly Pro Arg Leu Gly Val Arg Ala 
        35                  40                  45              


Thr Arg Lys Thr Ser Glu Arg Ser Gln Pro Arg Glu Arg Arg Gln Pro 
    50                  55                  60                  


Ile Pro Lys Ala Arg Arg Ser Asp Gly Arg Ser Trp Ala Gln Pro Gly 
65                  70                  75                  80  


Tyr Pro Trp Pro Leu Tyr Gly Asn Glu Gly Cys Gly Trp Ala Gly Trp 
                85                  90                  95      


Leu Leu Ser Pro Arg Gly Ser Arg Pro Ser Trp Gly Pro Asn Asp Pro 
            100                 105                 110         


Arg Arg Arg Ser Arg Asn Leu Gly Lys Val Ile Asp Thr Leu Thr Cys 
        115                 120                 125             


Gly Phe Ala Asp Leu Met Gly Tyr Ile Pro Ile Val Gly Ala Pro Val 
    130                 135                 140                 


Gly Gly Val Ala Arg Ala Leu Ala His Gly Val Arg Ala Leu Glu Asp 
145                 150                 155                 160 


Gly Ile Asn Phe Ala Thr Gly Asn Leu Pro Gly Cys Ser Phe Ser Ile 
                165                 170                 175     


Phe Leu Leu Ala Leu Leu Ser Cys Leu Ile His Pro Ala Ala Ser Leu 
            180                 185                 190         


Glu Trp Arg Asn Thr Ser Gly Leu Tyr Ile Leu Thr Asn Asp Cys Pro 
        195                 200                 205             


Asn Ser Ser Ile Val Tyr Glu Ala Asp Asp Val Ile Leu His Thr Pro 
    210                 215                 220                 


Gly Cys Ile Pro Cys Val Gln Asp Gly Asn Thr Ser Thr Cys Trp Thr 
225                 230                 235                 240 


Ser Val Ser Pro Thr Val Ala Val Arg Tyr Val Gly Ala Thr Thr Ala 
                245                 250                 255     


Ser Ile Arg Ser His Val Asp Leu Leu Val Gly Ala Ala Thr Leu Cys 
            260                 265                 270         


Ser Ala Leu Tyr Val Gly Asp Met Cys Gly Ala Val Phe Leu Val Gly 
        275                 280                 285             


Gln Ala Phe Thr Phe Arg Pro Arg Arg His Gln Thr Val Gln Thr Cys 
    290                 295                 300                 


Asn Cys Ser Leu Tyr Pro Gly His Leu Thr Gly His Arg Met Ala Trp 
305                 310                 315                 320 


Asp Met Met Met Asn Trp Ser Pro Ala Val Gly Met Val Val Ala His 
                325                 330                 335     


Val Leu Arg Met Pro Gln Thr Val Phe Asp Ile Ile Ala Gly Ala His 
            340                 345                 350         


Trp Gly Ile Leu Ala Gly Leu Ala Tyr Tyr Ser Met Gln Gly Asn Trp 
        355                 360                 365             


Ala Lys Val Ala Ile Ile Met Val Met Phe Ser Gly Val Asp Ala Glu 
    370                 375                 380                 


Thr His Thr Thr Gly Gly Thr Ala Ala Arg Asn Ala Phe Thr Leu Thr 
385                 390                 395                 400 


Gly Leu Phe Thr Gln Gly Ala Arg Gln Lys Leu Gln Leu Ile Asn Thr 
                405                 410                 415     


Asn Gly Ser Trp His Ile Asn Arg Thr Ala Leu Asn Cys Asn Glu Ser 
            420                 425                 430         


Leu Asn Thr Gly Phe Ile Ala Gly Leu Phe Tyr Leu His Lys Phe Asn 
        435                 440                 445             


Ser Thr Gly Cys Pro Glu Arg Leu Ser Ser Cys Lys Pro Ile Thr Phe 
    450                 455                 460                 


Phe Arg Gln Gly Trp Gly Ser Leu Thr Asp Ala Asn Ile Thr Gly Pro 
465                 470                 475                 480 


Ser Asp Asp Lys Pro Tyr Cys Trp His Tyr Ala Pro Arg Pro Cys Glu 
                485                 490                 495     


Val Val Pro Ala Leu Asn Val Cys Gly Pro Val Tyr Cys Phe Thr Pro 
            500                 505                 510         


Ser Pro Val Val Val Gly Thr Thr Asp Arg Gln Gly Val Pro Thr Tyr 
        515                 520                 525             


Thr Trp Gly Glu Asn Glu Thr Asp Val Phe Leu Leu Arg Ser Leu Arg 
    530                 535                 540                 


Pro Pro Ser Gly Gln Trp Phe Gly Cys Thr Trp Met Asn Ser Thr Gly 
545                 550                 555                 560 


Phe Val Lys Thr Cys Gly Ala Pro Pro Cys Asp Ile Tyr Gly Gly Gly 
                565                 570                 575     


Gly Asn Arg Cys Asn Glu Ser Asp Leu Phe Cys Pro Thr Asp Cys Phe 
            580                 585                 590         


Arg Lys His Pro Glu Ala Thr Tyr Ser Arg Cys Gly Ala Gly Pro Trp 
        595                 600                 605             


Leu Thr Pro Arg Cys Leu Val Asp Tyr Pro Tyr Arg Leu Trp His Tyr 
    610                 615                 620                 


Pro Cys Thr Val Asn Phe Thr Leu Phe Lys Val Arg Met Phe Val Gly 
625                 630                 635                 640 


Gly Phe Glu His Arg Phe Thr Ala Ala Cys Asn Trp Thr Arg Gly Glu 
                645                 650                 655     


Arg Cys Asn Ile Glu Asp Arg Asp Arg Ser Glu Gln His Pro Leu Leu 
            660                 665                 670         


His Ser Thr Thr Glu Leu Ala Ile Leu Pro Cys Ser Phe Thr Pro Met 
        675                 680                 685             


Pro Ala Leu Ser Thr Gly Leu Ile His Leu His Gln Asn Ile Val Asp 
    690                 695                 700                 


Val Gln Tyr Leu Tyr Gly Val Gly Ser Gly Val Val Gly Trp Ala Leu 
705                 710                 715                 720 


Arg Trp Glu Phe Val Val Leu Val Phe Leu Leu Leu Ala Asp Ala Arg 
                725                 730                 735     


Val Cys Val Ala Leu Trp Leu Met Leu Met Ile Ser Gln Ala Glu Ala 
            740                 745                 750         


Ala Leu Glu Asn Leu Val Thr Leu Asn Ala Val Ala Ala Ala Gly Thr 
        755                 760                 765             


His Gly Ile Gly Trp Tyr Leu Val Ala Phe Cys Ala Ala Trp His Leu 
    770                 775                 780                 


Arg Gly Lys Leu Val Pro Leu Val Thr Tyr Ser Leu Thr Gly Leu Trp 
785                 790                 795                 800 


Ser Leu Ala Val Leu Val Leu Leu Leu Pro Gln Arg Ala Tyr Ala Trp 
                805                 810                 815     


Ser Gly Glu Asp Ser Ala Thr Leu Gly Ala Gly Ile Leu Val Leu Phe 
            820                 825                 830         


Gly Phe Phe Thr Leu Ser Pro Trp Tyr Lys His Trp Ile Gly Arg Leu 
        835                 840                 845             


Met Trp Trp Asn Gln Tyr Thr Ile Cys Arg Cys Glu Ala Ala Leu Gln 
    850                 855                 860                 


Val Trp Val Pro Pro Leu Leu Ala Arg Gly Ser Arg Asp Gly Ala Ile 
865                 870                 875                 880 


Leu Leu Thr Ser Leu Leu Tyr Pro Ser Leu Ile Phe Asp Ile Thr Lys 
                885                 890                 895     


Leu Leu Ile Ala Val Leu Gly Pro Leu Tyr Leu Ile Gln Ala Ala Ile 
            900                 905                 910         


Thr Thr Thr Pro Tyr Phe Val Arg Ala His Val Leu Val Arg Leu Cys 
        915                 920                 925             


Met Leu Val Arg Ser Val Met Gly Gly Lys Tyr Phe Gln Met Ile Ile 
    930                 935                 940                 


Leu Ser Ile Gly Arg Trp Phe Asn Thr Tyr Leu Tyr Asp His Leu Ala 
945                 950                 955                 960 


Pro Met Gln His Trp Ala Ala Ala Gly Leu Lys Asp Leu Ala Val Ala 
                965                 970                 975     


Thr Glu Pro Val Ile Phe Ser Pro Met Glu Ile Lys Val Ile Thr Trp 
            980                 985                 990         


Gly Ala Asp Thr Ala Ala Cys Gly  Asp Ile Leu Cys Gly  Leu Pro Val 
        995                 1000                 1005             


Ser Ala  Arg Leu Gly His Glu  Val Leu Leu Gly Pro  Ala Asp Asp 
    1010                 1015                 1020             


Tyr Arg  Glu Met Gly Trp Arg  Leu Leu Ala Pro Ile  Thr Ala Tyr 
    1025                 1030                 1035             


Ala Gln  Gln Thr Arg Gly Leu  Leu Gly Thr Ile Val  Thr Ser Leu 
    1040                 1045                 1050             


Thr Gly  Arg Asp Lys Asn Val  Val Thr Gly Glu Val  Gln Val Leu 
    1055                 1060                 1065             


Ser Thr  Ala Thr Gln Thr Phe  Leu Gly Thr Thr Ile  Gly Gly Val 
    1070                 1075                 1080             


Met Trp  Thr Val Tyr His Gly  Ala Gly Ser Arg Thr  Leu Ala Gly 
    1085                 1090                 1095             


Val Lys  His Pro Ala Leu Gln  Met Tyr Thr Asn Val  Asp Gln Asp 
    1100                 1105                 1110             


Leu Val  Gly Trp Pro Ala Pro  Pro Gly Ala Lys Ser  Leu Glu Pro 
    1115                 1120                 1125             


Cys Ser  Cys Gly Ser Thr Asp  Leu Tyr Leu Val Thr  Arg Glu Ala 
    1130                 1135                 1140             


Asp Val  Ile Pro Ala Arg Arg  Arg Gly Asp Ser Thr  Ala Ser Leu 
    1145                 1150                 1155             


Leu Ser  Pro Arg Pro Leu Ala  Cys Leu Lys Gly Ser  Ser Gly Gly 
    1160                 1165                 1170             


Pro Val  Met Cys Pro Ser Gly  His Val Ala Gly Ile  Phe Arg Ala 
    1175                 1180                 1185             


Ala Val  Cys Thr Arg Gly Val  Ala Lys Ala Leu Gln  Phe Ile Pro 
    1190                 1195                 1200             


Val Glu  Thr Leu Ser Ala Gln  Ala Arg Ser Pro Ser  Phe Ser Asp 
    1205                 1210                 1215             


Asn Ser  Thr Pro Pro Ile Val  Pro Gln Ser Tyr Gln  Val Gly Tyr 
    1220                 1225                 1230             


Leu His  Ala Pro Thr Gly Ser  Gly Lys Ser Thr Lys  Val Pro Ala 
    1235                 1240                 1245             


Ala Tyr  Val Ala Gln Gly Tyr  Asn Val Leu Val Leu  Asn Pro Ser 
    1250                 1255                 1260             


Val Ala  Ala Thr Leu Gly Phe  Gly Ser Phe Met Ser  Arg Ala Tyr 
    1265                 1270                 1275             


Gly Ile  Asp Pro Asn Ile Arg  Thr Gly Asn Arg Thr  Val Thr Thr 
    1280                 1285                 1290             


Gly Ala  Lys Leu Thr Tyr Ser  Thr Tyr Gly Lys Phe  Leu Ala Asp 
    1295                 1300                 1305             


Gly Gly  Cys Ser Gly Gly Ala  Tyr Asp Val Ile Ile  Cys Asp Glu 
    1310                 1315                 1320             


Cys His  Ala Gln Asp Ala Thr  Ser Ile Leu Gly Ile  Gly Thr Val 
    1325                 1330                 1335             


Leu Asp  Gln Ala Glu Thr Ala  Gly Val Arg Leu Thr  Val Leu Ala 
    1340                 1345                 1350             


Thr Ala  Thr Pro Pro Gly Ser  Ile Thr Val Pro His  Ser Asn Ile 
    1355                 1360                 1365             


Glu Glu  Val Ala Leu Gly Ser  Glu Gly Glu Ile Pro  Phe Tyr Gly 
    1370                 1375                 1380             


Lys Ala  Ile Pro Leu Ala Gln  Leu Lys Gly Gly Arg  His Leu Ile 
    1385                 1390                 1395             


Phe Cys  His Ser Lys Lys Lys  Cys Asp Glu Met Ala  Ser Lys Leu 
    1400                 1405                 1410             


Arg Gly  Met Gly Leu Asn Ala  Val Ala Tyr Tyr Arg  Gly Leu Asp 
    1415                 1420                 1425             


Val Ser  Val Ile Pro Thr Ala  Gly Asp Val Val Val  Cys Ala Thr 
    1430                 1435                 1440             


Asp Ala  Leu Met Thr Gly Phe  Thr Gly Asp Phe Asp  Ser Val Ile 
    1445                 1450                 1455             


Asp Cys  Asn Val Thr Val Glu  Gln Tyr Val Asp Phe  Ser Leu Asp 
    1460                 1465                 1470             


Pro Thr  Phe Ser Ile Glu Thr  Arg Thr Ala Pro Gln  Asp Ala Val 
    1475                 1480                 1485             


Ser Arg  Ser Gln Arg Arg Gly  Arg Thr Gly Arg Gly  Arg Leu Gly 
    1490                 1495                 1500             


Thr Tyr  Arg Tyr Val Ala Pro  Gly Glu Arg Pro Ser  Gly Met Phe 
    1505                 1510                 1515             


Asp Ser  Val Val Leu Cys Glu  Cys Tyr Asp Ala Gly  Cys Ser Trp 
    1520                 1525                 1530             


Tyr Asp  Leu Gln Pro Ala Glu  Thr Thr Val Arg Leu  Arg Ala Tyr 
    1535                 1540                 1545             


Leu Ser  Thr Pro Gly Leu Pro  Val Cys Gln Asp His  Leu Asp Phe 
    1550                 1555                 1560             


Trp Glu  Ser Val Phe Thr Gly  Leu Thr His Ile Asp  Ala His Phe 
    1565                 1570                 1575             


Leu Ser  Gln Thr Lys Gln Gln  Gly Leu Asn Phe Ser  Tyr Leu Thr 
    1580                 1585                 1590             


Ala Tyr  Gln Ala Thr Val Cys  Ala Arg Ala Gln Ala  Pro Pro Pro 
    1595                 1600                 1605             


Ser Trp  Asp Glu Met Trp Lys  Cys Leu Leu Arg Leu  Lys Pro Thr 
    1610                 1615                 1620             


Leu His  Gly Pro Thr Pro Leu  Leu Tyr Arg Leu Gly  Pro Val Gln 
    1625                 1630                 1635             


Asn Glu  Thr Cys Leu Thr His  Pro Val Thr Lys Tyr  Ile Met Ala 
    1640                 1645                 1650             


Cys Met  Ser Ala Asp Leu Glu  Val Thr Thr Ser Thr  Trp Val Leu 
    1655                 1660                 1665             


Leu Gly  Gly Val Leu Ala Ala  Leu Ala Ala Tyr Cys  Leu Ser Val 
    1670                 1675                 1680             


Gly Cys  Val Val Ile Val Gly  His Ile Glu Leu Gly  Gly Lys Pro 
    1685                 1690                 1695             


Ala Leu  Ile Pro Asp Lys Glu  Val Leu Tyr Gln Gln  Tyr Asp Glu 
    1700                 1705                 1710             


Met Glu  Glu Cys Ser Gln Ala  Ala Pro Tyr Val Glu  Gln Ala Gln 
    1715                 1720                 1725             


Ala Ile  Ala His Gln Phe Lys  Glu Lys Leu Leu Gly  Leu Leu Gln 
    1730                 1735                 1740             


Arg Ala  Thr Gln Gln Gln Ala  Val Ile Glu Pro Ile  Val Ala Thr 
    1745                 1750                 1755             


Asn Trp  Gln Lys Leu Glu Ala  Phe Trp His Lys His  Met Trp Asn 
    1760                 1765                 1770             


Phe Val  Ser Gly Ile Gln Tyr  Leu Ala Gly Leu Ser  Thr Leu Pro 
    1775                 1780                 1785             


Gly Asn  Pro Ala Val Ala Ser  Leu Met Ala Phe Thr  Ala Ser Val 
    1790                 1795                 1800             


Thr Ser  Pro Leu Thr Thr Asn  Gln Thr Met Phe Phe  Asn Ile Leu 
    1805                 1810                 1815             


Gly Gly  Trp Val Ala Thr His  Leu Ala Gly Pro Gln  Ser Ser Ser 
    1820                 1825                 1830             


Ala Phe  Val Val Ser Gly Leu  Ala Gly Ala Ala Ile  Gly Gly Ile 
    1835                 1840                 1845             


Gly Leu  Gly Arg Val Leu Leu  Asp Ile Leu Ala Gly  Tyr Gly Ala 
    1850                 1855                 1860             


Gly Val  Ser Gly Ala Leu Val  Ala Phe Lys Ile Met  Gly Gly Glu 
    1865                 1870                 1875             


Ile Pro  Thr Ala Glu Asp Met  Val Asn Leu Leu Pro  Ala Ile Leu 
    1880                 1885                 1890             


Ser Pro  Gly Ala Leu Val Val  Gly Val Ile Cys Ala  Ala Ile Leu 
    1895                 1900                 1905             


Arg Arg  His Val Gly Pro Gly  Glu Gly Ala Val Gln  Trp Met Asn 
    1910                 1915                 1920             


Arg Leu  Ile Ala Phe Ala Ser  Arg Gly Asn His Val  Ser Pro Thr 
    1925                 1930                 1935             


His Tyr  Val Pro Glu Ser Asp  Ala Ala Ala Arg Val  Thr Ala Leu 
    1940                 1945                 1950             


Leu Ser  Ser Leu Thr Val Thr  Ser Leu Leu Arg Arg  Leu His His 
    1955                 1960                 1965             


Trp Ile  Asn Glu Asp Tyr Pro  Ser Pro Cys Ser Gly  Asp Trp Leu 
    1970                 1975                 1980             


Arg Thr  Ile Trp Asp Trp Val  Cys Met Val Leu Ser  Asp Phe Arg 
    1985                 1990                 1995             


Thr Trp  Leu Ser Ala Lys Ile  Met Pro Ala Leu Pro  Gly Leu Pro 
    2000                 2005                 2010             


Phe Leu  Ser Cys Gln Lys Gly  Tyr Lys Gly Val Trp  Arg Gly Asp 
    2015                 2020                 2025             


Gly Val  Val Ser Thr Arg Cys  Pro Cys Gly Ala Ser  Ile Thr Gly 
    2030                 2035                 2040             


His Val  Lys Asn Gly Ser Met  Arg Leu Ala Gly Pro  Arg Thr Cys 
    2045                 2050                 2055             


Ala Asn  Met Trp His Gly Thr  Phe Pro Ile Asn Glu  Tyr Thr Thr 
    2060                 2065                 2070             


Gly Pro  Ser Thr Pro Cys Pro  Ser Pro Asn Tyr Thr  Arg Ala Leu 
    2075                 2080                 2085             


Trp Arg  Val Ala Ala Asn Ser  Tyr Val Glu Val Arg  Gln Val Gly 
    2090                 2095                 2100             


Asp Phe  His Tyr Ile Thr Gly  Ala Thr Glu Asp Gly  Leu Lys Cys 
    2105                 2110                 2115             


Pro Cys  Gln Val Pro Ala Ala  Glu Phe Phe Thr Glu  Val Asp Gly 
    2120                 2125                 2130             


Val Arg  Leu His Arg Tyr Ala  Pro Pro Cys Lys Pro  Leu Leu Arg 
    2135                 2140                 2145             


Asp Glu  Ile Thr Phe Met Val  Gly Leu Asn Ser Tyr  Ala Ile Gly 
    2150                 2155                 2160             


Ser Gln  Leu Pro Cys Glu Pro  Glu Pro Asp Val Ser  Val Leu Thr 
    2165                 2170                 2175             


Ser Met  Leu Arg Asp Pro Ser  His Ile Thr Ala Glu  Thr Ala Ala 
    2180                 2185                 2190             


Arg Arg  Leu Ala Arg Gly Ser  Pro Pro Ser Glu Ala  Ser Ser Ser 
    2195                 2200                 2205             


Ala Ser  Gln Leu Ser Ala Pro  Ser Leu Lys Ala Thr  Cys Gln Thr 
    2210                 2215                 2220             


His Arg  Pro His Pro Asp Ala  Glu Leu Val Asp Ala  Asn Leu Leu 
    2225                 2230                 2235             


Trp Arg  Gln Glu Met Gly Ser  Asn Ile Thr Arg Val  Glu Ser Glu 
    2240                 2245                 2250             


Thr Lys  Val Val Ile Leu Asp  Ser Phe Glu Pro Leu  Arg Ala Glu 
    2255                 2260                 2265             


Ala Asp  Asp Ala Glu Leu Ser  Val Ala Ala Glu Cys  Phe Lys Lys 
    2270                 2275                 2280             


Pro Pro  Lys Tyr Pro Pro Ala  Leu Pro Ile Trp Ala  Arg Pro Asp 
    2285                 2290                 2295             


Tyr Asn  Pro Pro Leu Leu Asp  Arg Trp Lys Thr Pro  Asp Tyr Val 
    2300                 2305                 2310             


Pro Pro  Thr Val His Gly Cys  Ala Leu Pro Pro Arg  Gly Ala Pro 
    2315                 2320                 2325             


Pro Val  Pro Pro Pro Arg Arg  Lys Arg Thr Val Gln  Leu Asp Gly 
    2330                 2335                 2340             


Ser Asn  Val Ser Ala Ala Leu  Ala Ala Leu Ala Glu  Lys Ser Phe 
    2345                 2350                 2355             


Pro Ser  Leu Glu Pro Gln Gly  Glu Asn Ser Ser Ser  Ser Gly Ile 
    2360                 2365                 2370             


Asp Ile  Gln Ser Ser Thr Ala  Ser Glu Val Pro Pro  Ser Pro Glu 
    2375                 2380                 2385             


Gly Glu  Ser Asp Ser Glu Ser  Cys Thr Ser Met Pro  Pro Leu Glu 
    2390                 2395                 2400             


Gly Glu  Pro Gly Asp Pro Asp  Leu Ser Cys Asp Ser  Trp Ser Thr 
    2405                 2410                 2415             


Val Ser  Asp Ser Glu Glu Gln  Ser Val Val Cys Cys  Ser Met Ser 
    2420                 2425                 2430             


Tyr Ser  Trp Thr Gly Ala Leu  Ile Thr Pro Cys Ser  Ala Glu Glu 
    2435                 2440                 2445             


Glu Lys  Leu Pro Ile Ser Pro  Leu Ser Asn Ser Leu  Leu Arg His 
    2450                 2455                 2460             


His Asn  Leu Val Tyr Ser Thr  Ser Ser Arg Ser Ala  Ser Gln Arg 
    2465                 2470                 2475             


Gln Lys  Lys Val Thr Phe Asp  Arg Leu Gln Val Leu  Asp Asp His 
    2480                 2485                 2490             


Tyr Lys  Ala Val Leu Lys Glu  Val Lys Glu Arg Ala  Ser Arg Val 
    2495                 2500                 2505             


Lys Ala  Arg Met Leu Thr Ile  Glu Glu Ala Cys Ala  Leu Val Pro 
    2510                 2515                 2520             


Pro His  Ser Ala Arg Ser Lys  Phe Gly Tyr Ser Ala  Lys Asp Val 
    2525                 2530                 2535             


Arg Ser  Leu Ser Gly Arg Ala  Val Asn Gln Ile Arg  Ser Val Trp 
    2540                 2545                 2550             


Glu Asp  Leu Leu Glu Asp Thr  Thr Thr Pro Ile Pro  Thr Thr Ile 
    2555                 2560                 2565             


Met Ala  Lys Asn Glu Val Phe  Cys Val Asp Pro Ser  Lys Gly Gly 
    2570                 2575                 2580             


Arg Lys  Pro Ala Arg Leu Ile  Val Tyr Pro Asp Leu  Gly Val Arg 
    2585                 2590                 2595             


Val Cys  Glu Lys Arg Ala Leu  Tyr Asp Val Ile Gln  Lys Leu Ser 
    2600                 2605                 2610             


Ile Ala  Thr Met Gly Ser Ala  Tyr Gly Phe Gln Tyr  Ser Pro Gln 
    2615                 2620                 2625             


Gln Arg  Val Glu Arg Leu Leu  Glu Met Trp Thr Ser  Lys Lys Thr 
    2630                 2635                 2640             


Pro Met  Gly Phe Ser Tyr Asp  Thr Arg Cys Phe Asp  Ser Thr Val 
    2645                 2650                 2655             


Thr Glu  Gln Asp Ile Arg Val  Glu Glu Glu Ile Tyr  Gln Cys Cys 
    2660                 2665                 2670             


Asn Leu  Glu Pro Glu Ala Arg  Lys Val Ile Ser Ser  Leu Thr Glu 
    2675                 2680                 2685             


Arg Leu  Tyr Cys Gly Gly Pro  Met Phe Asn Ser Lys  Gly Ala Gln 
    2690                 2695                 2700             


Cys Gly  Tyr Arg Arg Cys Arg  Ala Ser Gly Val Leu  Pro Thr Ser 
    2705                 2710                 2715             


Phe Gly  Asn Thr Ile Thr Cys  Tyr Ile Lys Ala Thr  Ala Ala Ala 
    2720                 2725                 2730             


Arg Ala  Ala Gly Leu Arg Asn  Pro Asp Phe Leu Val  Cys Gly Asp 
    2735                 2740                 2745             


Asp Leu  Val Leu Val Ala Glu  Ser Asp Gly Val Asp  Glu Asp Arg 
    2750                 2755                 2760             


Ala Ala  Leu Arg Ala Phe Thr  Glu Ala Met Thr Arg  Tyr Ser Ala 
    2765                 2770                 2775             


Pro Pro  Gly Asp Ala Pro Gln  Pro Thr Tyr Asp Leu  Glu Leu Ile 
    2780                 2785                 2790             


Thr Ser  Cys Ser Ser Asn Val  Ser Val Ala Arg Asp  Asn Lys Gly 
    2795                 2800                 2805             


Lys Arg  Tyr Tyr Tyr Leu Thr  Arg Asp Ala Thr Thr  Pro Leu Ala 
    2810                 2815                 2820             


Arg Ala  Ala Trp Glu Thr Ala  Arg His Thr Pro Val  Asn Ser Trp 
    2825                 2830                 2835             


Leu Gly  Asn Ile Ile Met Tyr  Ala Pro Thr Ile Trp  Val Arg Met 
    2840                 2845                 2850             


Val Met  Met Thr His Phe Phe  Ser Ile Leu Gln Ser  Gln Glu Ile 
    2855                 2860                 2865             


Leu Asp  Arg Pro Leu Asp Phe  Glu Met Tyr Gly Ala  Thr Tyr Ser 
    2870                 2875                 2880             


Val Thr  Pro Leu Asp Leu Pro  Ala Ile Ile Glu Arg  Leu His Gly 
    2885                 2890                 2895             


Leu Ser  Ala Phe Thr Leu His  Ser Tyr Ser Pro Val  Glu Leu Asn 
    2900                 2905                 2910             


Arg Val  Ala Gly Thr Leu Arg  Lys Leu Gly Cys Pro  Pro Leu Arg 
    2915                 2920                 2925             


Ala Trp  Arg His Arg Ala Arg  Ala Val Arg Ala Lys  Leu Ile Ala 
    2930                 2935                 2940             


Gln Gly  Gly Lys Ala Lys Ile  Cys Gly Leu Tyr Leu  Phe Asn Trp 
    2945                 2950                 2955             


Ala Val  Arg Thr Lys Thr Asn  Leu Thr Pro Leu Pro  Ala Ala Gly 
    2960                 2965                 2970             


Gln Leu  Asp Leu Ser Ser Trp  Phe Thr Val Gly Val  Gly Gly Asn 
    2975                 2980                 2985             


Asp Ile  Tyr His Ser Val Ser  Arg Ala Arg Thr Arg  His Leu Leu 
    2990                 2995                 3000             


Leu Cys  Leu Leu Leu Leu Thr  Val Gly Val Gly Ile  Phe Leu Leu 
    3005                 3010                 3015             


Pro Ala  Arg 
    3020     


<210>  108
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Sequence


<220>
<221>  Misc_feature
<222>  (1)..(5)
<223>  This stretch of residues may be repeated

<400>  108

Gly Ser Gly Gly Ser 
1               5   


<210>  109
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Sequence


<220>
<221>  Misc_feature
<222>  (1)..(6)
<223>  This stretch of residues may be repeated

<400>  109

Gly Gly Ser Gly Gly Ser 
1               5       


<210>  110
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Sequence


<220>
<221>  Misc_feature
<222>  (1)..(4)
<223>  This stretch of residues may be repeated

<400>  110

Gly Gly Gly Ser 
1               


<210>  111
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Sequence

<400>  111

Gly Gly Ser Gly 
1               


<210>  112
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Sequence

<400>  112

Gly Gly Ser Gly Gly 
1               5   


<210>  113
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Sequence

<400>  113

Gly Ser Gly Ser Gly 
1               5   


<210>  114
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Sequence

<400>  114

Gly Ser Gly Gly Gly 
1               5   


<210>  115
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Sequence

<400>  115

Gly Gly Gly Ser Gly 
1               5   


<210>  116
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Sequence

<400>  116

Gly Ser Ser Ser Gly 
1               5   


<210>  117
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Sequence

<400>  117

Leu Glu Val Leu Phe Gln Gly Pro 
1               5               


<210>  118
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Sequence

<400>  118

Glu Asn Leu Tyr Phe Gln Ser 
1               5           


<210>  119
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Sequence

<400>  119

Glu Asn Leu Tyr Phe Gln Gly 
1               5           


<210>  120
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Sequence

<400>  120

Leu Val Pro Arg Gly Ser 
1               5       


<210>  121
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Sequence


<220>
<221>  Misc_feature
<222>  (2)..(2)
<223>  X is E or D

<220>
<221>  Misc_feature
<222>  (5)..(5)
<223>  X can be any amino acid except for arginine or 
       proline

<400>  121

Ile Xaa Gly Arg Xaa 
1               5   


<210>  122
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Sequence

<400>  122

Leu Glu Val Leu Phe Gln 
1               5       


<210>  123
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Sequence

<400>  123

Asp Asp Asp Asp Lys 
1               5   


<210>  124
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Sequence

<400>  124

Leu Val Pro Arg 
1               


<210>  125
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Sequence


<220>
<221>  Misc_feature
<222>  (2)..(2)
<223>  X is E or D

<400>  125

Ile Xaa Gly Arg 
1               


<210>  126
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Sequence

<400>  126

Asp Tyr Lys Asp Asp Asp Asp Lys 
1               5               


<210>  127
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Sequence

<400>  127

Tyr Pro Tyr Asp Val Pro Asp Tyr Ala 
1               5                   


<210>  128
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Sequence

<400>  128

Glu Gln Lys Leu Ile Ser Glu Glu Asp Leu 
1               5                   10  


<210>  129
<211>  191
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Sequence

<400>  129

Met Ser Thr Asn Pro Lys Pro Gln Arg Lys Thr Lys Arg Asn Thr Asn 
1               5                   10                  15      


Arg Arg Pro Gln Asp Val Lys Phe Pro Gly Gly Gly Gln Ile Val Gly 
            20                  25                  30          


Gly Val Tyr Leu Leu Pro Arg Arg Gly Pro Arg Leu Gly Val Arg Ala 
        35                  40                  45              


Thr Arg Lys Thr Ser Glu Arg Ser Gln Pro Arg Gly Arg Arg Gln Pro 
    50                  55                  60                  


Ile Pro Lys Ala Arg Arg Pro Glu Gly Arg Thr Trp Ala Gln Pro Gly 
65                  70                  75                  80  


Tyr Pro Trp Pro Leu Tyr Gly Asn Glu Gly Cys Gly Trp Ala Gly Trp 
                85                  90                  95      


Leu Leu Ser Pro Arg Gly Ser Arg Pro Ser Trp Gly Pro Thr Asp Pro 
            100                 105                 110         


Arg Arg Arg Ser Arg Asn Leu Gly Lys Val Ile Asp Thr Leu Thr Cys 
        115                 120                 125             


Gly Phe Ala Asp Leu Met Gly Tyr Ile Pro Leu Val Gly Ala Pro Leu 
    130                 135                 140                 


Gly Gly Ala Ala Arg Ala Leu Ala His Gly Val Arg Val Leu Glu Asp 
145                 150                 155                 160 


Gly Val Asn Tyr Ala Thr Gly Asn Leu Pro Gly Cys Ser Phe Ser Ile 
                165                 170                 175     


Phe Leu Leu Ala Leu Leu Ser Cys Leu Thr Val Pro Ala Ser Ala 
            180                 185                 190     


<210>  130
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Sequence

<400>  130

Gln Tyr Ile Lys Ala Asn Ser Lys Phe Ile Gly Ile Phe Glu 
1               5                   10                  


<210>  131
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Sequence

<400>  131

Gln Tyr Ile Lys Ala Asn Ser Lys Phe Ile Gly Ile Thr Glu 
1               5                   10                  


<210>  132
<211>  124
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Sequence

<400>  132

Met Ile Lys Leu Lys Phe Gly Val Phe Phe Thr Val Leu Leu Ser Ser 
1               5                   10                  15      


Ala Tyr Ala His Gly Thr Pro Gln Asn Ile Thr Asp Leu Cys Ala Glu 
            20                  25                  30          


Tyr His Asn Thr Gln Ile His Thr Leu Asn Asp Lys Ile Phe Ser Tyr 
        35                  40                  45              


Thr Glu Ser Leu Ala Gly Lys Arg Glu Met Ala Ile Ile Thr Phe Lys 
    50                  55                  60                  


Asn Gly Ala Thr Phe Gln Val Glu Val Pro Gly Ser Gln His Ile Asp 
65                  70                  75                  80  


Ser Gln Lys Lys Ala Ile Glu Arg Met Lys Asp Thr Leu Arg Ile Ala 
                85                  90                  95      


Tyr Leu Thr Glu Ala Lys Val Glu Lys Leu Cys Val Trp Asn Asn Lys 
            100                 105                 110         


Thr Pro His Ala Ile Ala Ala Ile Ser Met Ala Asn 
        115                 120                 


<210>  133
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Sequence

<400>  133

Ile Leu Met Gln Tyr Ile Lys Ala Asn Ser Lys Phe Ile Gly Ile 
1               5                   10                  15  


<210>  134
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Sequence

<400>  134

Val Asn Asn Glu Ser Ser Glu 
1               5           


<210>  135
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Sequence

<400>  135

Pro Gly Ile Asn Gly Lys Ala Ile His Leu Val Asn Asn Glu Ser Ser 
1               5                   10                  15      


Glu 
    


<210>  136
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Sequence

<400>  136

Pro Asn Arg Asp Ile Leu 
1               5       


<210>  137
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Sequence

<400>  137

Phe Ile Gly Ile Thr Glu Leu 
1               5           


<210>  138
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Sequence

<400>  138

Ser Tyr Phe Pro Ser Val 
1               5       


<210>  139
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Sequence

<400>  139

Asn Ser Val Asp Asp Ala Leu Ile Asn Ser Thr Lys Ile Tyr Ser Tyr 
1               5                   10                  15      


Phe Pro Ser Val 
            20  


<210>  140
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Sequence

<400>  140

Ile Asp Lys Ile Ser Asp Val Ser Thr Ile Val Pro Tyr Ile Gly Pro 
1               5                   10                  15      


Ala Leu Asn Ile 
            20  


<210>  141
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Sequence

<400>  141

Gln Ser Ile Ala Leu Ser Ser Leu Met Val Ala Gln Ala Ile Pro 
1               5                   10                  15  


<210>  142
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Sequence

<400>  142

Pro Val Phe Ala Gly Ala Asn Tyr Ala Ala Trp Ala Val Asn Val Ala 
1               5                   10                  15      


Gln Val Ile 
            


<210>  143
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Sequence

<400>  143

Val His His Asn Thr Glu Glu Ile Val Ala Gln Ser Ile Ala Leu Ser 
1               5                   10                  15      


Ser Leu Met Val 
            20  


<210>  144
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Sequence

<400>  144

Gln Ser Ile Ala Leu Ser Ser Leu Met Val Ala Gln Ala Ile Pro Leu 
1               5                   10                  15      


Val Gly Glu Leu 
            20  


<210>  145
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Sequence

<400>  145

Val Asp Ile Gly Phe Ala Ala Tyr Asn Phe Val Glu Ser Ile Ile Asn 
1               5                   10                  15      


Leu Phe Gln Val 
            20  


<210>  146
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Sequence

<400>  146

Gln Gly Glu Ser Gly His Asp Ile Lys Ile Thr Ala Glu Asn Thr Pro 
1               5                   10                  15      


Leu Pro Ile Ala 
            20  


<210>  147
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Sequence

<400>  147

Gly Val Leu Leu Pro Thr Ile Pro Gly Lys Leu Asp Val Asn Lys Ser 
1               5                   10                  15      


Lys Thr His Ile 
            20  


<210>  148
<211>  534
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Sequence

<400>  148

Ala Asp Asp Val Val Asp Ser Ser Lys Ser Phe Val Met Glu Asn Phe 
1               5                   10                  15      


Ser Ser Tyr His Gly Thr Lys Pro Gly Tyr Val Asp Ser Ile Gln Lys 
            20                  25                  30          


Gly Ile Gln Lys Pro Lys Ser Gly Thr Gln Gly Asn Tyr Asp Asp Asp 
        35                  40                  45              


Trp Lys Glu Phe Tyr Ser Thr Asp Asn Lys Tyr Asp Ala Ala Gly Tyr 
    50                  55                  60                  


Ser Val Asp Asn Glu Asn Pro Leu Ser Gly Lys Ala Gly Gly Val Val 
65                  70                  75                  80  


Lys Val Thr Tyr Pro Gly Leu Thr Lys Val Leu Ala Leu Lys Val Asp 
                85                  90                  95      


Asn Ala Glu Thr Ile Lys Lys Glu Leu Gly Leu Ser Leu Thr Glu Pro 
            100                 105                 110         


Leu Met Glu Gln Val Gly Thr Glu Glu Phe Ile Lys Arg Phe Gly Asp 
        115                 120                 125             


Gly Ala Ser Arg Val Val Leu Ser Leu Pro Phe Ala Glu Gly Ser Ser 
    130                 135                 140                 


Ser Val Glu Tyr Ile Asn Asn Trp Glu Gln Ala Lys Ala Leu Ser Val 
145                 150                 155                 160 


Glu Leu Glu Ile Asn Phe Glu Thr Arg Gly Lys Arg Gly Gln Asp Ala 
                165                 170                 175     


Met Tyr Glu Tyr Met Ala Gln Ala Cys Ala Gly Asn Arg Val Arg Arg 
            180                 185                 190         


Ser Val Gly Ser Ser Leu Ser Cys Ile Asn Leu Asp Trp Asp Val Ile 
        195                 200                 205             


Arg Asp Lys Thr Lys Thr Lys Ile Glu Ser Leu Lys Glu His Gly Pro 
    210                 215                 220                 


Ile Lys Asn Lys Met Ser Glu Ser Pro Asn Lys Thr Val Ser Glu Glu 
225                 230                 235                 240 


Lys Ala Lys Gln Tyr Leu Glu Glu Phe His Gln Thr Ala Leu Glu His 
                245                 250                 255     


Pro Glu Leu Ser Glu Leu Lys Thr Val Thr Gly Thr Asn Pro Val Phe 
            260                 265                 270         


Ala Gly Ala Asn Tyr Ala Ala Trp Ala Val Asn Val Ala Gln Val Ile 
        275                 280                 285             


Asp Ser Glu Thr Ala Asp Asn Leu Glu Lys Thr Thr Ala Ala Leu Ser 
    290                 295                 300                 


Ile Leu Pro Gly Ile Gly Ser Val Met Gly Ile Ala Asp Gly Ala Val 
305                 310                 315                 320 


His His Asn Thr Glu Glu Ile Val Ala Gln Ser Ile Ala Leu Ser Ser 
                325                 330                 335     


Leu Met Val Ala Gln Ala Ile Pro Leu Val Gly Glu Leu Val Asp Ile 
            340                 345                 350         


Gly Phe Ala Ala Tyr Asn Phe Val Glu Ser Ile Ile Asn Leu Phe Gln 
        355                 360                 365             


Val Val His Asn Ser Tyr Asn Arg Pro Ala Tyr Ser Pro Gly His Lys 
    370                 375                 380                 


Thr Gln Pro Phe Leu His Asp Gly Tyr Ala Val Ser Trp Asn Thr Val 
385                 390                 395                 400 


Glu Asp Ser Ile Ile Arg Thr Gly Phe Gln Gly Glu Ser Gly His Asp 
                405                 410                 415     


Ile Lys Ile Thr Ala Glu Asn Thr Pro Leu Pro Ile Ala Gly Val Leu 
            420                 425                 430         


Leu Pro Thr Ile Pro Gly Lys Leu Asp Val Asn Lys Ser Lys Thr His 
        435                 440                 445             


Ile Ser Val Asn Gly Arg Lys Ile Arg Met Arg Cys Arg Ala Ile Asp 
    450                 455                 460                 


Gly Asp Val Thr Phe Cys Arg Pro Lys Ser Pro Val Tyr Val Gly Asn 
465                 470                 475                 480 


Gly Val His Ala Asn Leu His Val Ala Phe His Arg Ser Ser Ser Glu 
                485                 490                 495     


Lys Ile His Ser Asn Glu Ile Ser Ser Asp Ser Ile Gly Val Leu Gly 
            500                 505                 510         


Tyr Gln Lys Thr Val Asp His Thr Lys Val Asn Ser Lys Leu Ser Leu 
        515                 520                 525             


Phe Phe Glu Ile Lys Ser 
    530                 


<210>  149
<211>  26
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic Sequence

<400>  149

Ile Met Gln Tyr Ile Lys Ala Asn Ser Lys Phe Ile Gly Ile Gln Ser 
1               5                   10                  15      


Ile Ala Leu Ser Ser Leu Met Val Ala Gln 
            20                  25      


<210>  150
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synethetic Sequence

<400>  150

Glu Asn Leu Tyr Tyr Phe Gln 
1               5           


<210>  151
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Sequence

<400>  151

Glu Asn Leu Tyr Tyr Phe Gln 
1               5           


