                         SEQUENCE LISTING

<110>  Nguyen, Hiep-Hoa T.
 
<120>  Mycobacterium tuberculosis Proteins in Diagnostic Assays and 
       Devices for Tuberculosis Detection and Diagnosis

<130>  PAC-001PCT1

<150>  62/398,213
<151>  2016-09-22

<160>  16    

<170>  PatentIn version 3.5

<210>  1
<211>  144
<212>  PRT
<213>  Mycobacterium tuberculosis

<400>  1

Met Ala Asp Lys Thr Thr Gln Thr Ile Tyr Ile Asp Ala Asp Pro Gly 
1               5                   10                  15      


Glu Val Met Lys Ala Ile Ala Asp Ile Glu Ala Tyr Pro Gln Trp Ile 
            20                  25                  30          


Ser Glu Tyr Lys Glu Val Glu Ile Leu Glu Ala Asp Asp Glu Gly Tyr 
        35                  40                  45              


Pro Lys Arg Ala Arg Met Leu Met Asp Ala Ala Ile Phe Lys Asp Thr 
    50                  55                  60                  


Leu Ile Met Ser Tyr Glu Trp Pro Glu Asp Arg Gln Ser Leu Ser Trp 
65                  70                  75                  80  


Thr Leu Glu Ser Ser Ser Leu Leu Lys Ser Leu Glu Gly Thr Tyr Arg 
                85                  90                  95      


Leu Ala Pro Lys Gly Ser Gly Thr Glu Val Thr Tyr Glu Leu Ala Val 
            100                 105                 110         


Asp Leu Ala Val Pro Met Ile Gly Met Leu Lys Arg Lys Ala Glu Arg 
        115                 120                 125             


Arg Leu Ile Asp Gly Ala Leu Lys Asp Leu Lys Lys Arg Val Glu Gly 
    130                 135                 140                 


<210>  2
<211>  435
<212>  DNA
<213>  Mycobacterium tuberculosis

<400>  2
gtggcggaca agacgacaca gacgatttac atcgacgcgg atccaggcga ggtgatgaag       60

gcgatcgccg acatcgaagc ctacccgcaa tggatttcgg agtataagga agtcgagatc      120

ctagaggccg acgacgaggg ctacccgaaa cgagcgcgaa tgttgatgga cgcagccatc      180

ttcaaagaca ccttgatcat gtcctacgag tggccggaag accgccaatc gcttagctgg      240

actctcgaat ccagctcgct gctaaagtcc ctcgaaggca cgtatcgctt ggcgcccaag      300

ggttctggca ctgaggtcac ctacgagctt gccgtcgacc ttgctgtccc catgatcggg      360

atgctcaagc gtaaggcgga acgcaggttg atagacggcg cgttgaagga tctgaagaaa      420

cgagtcgagg gctga                                                       435


<210>  3
<211>  129
<212>  PRT
<213>  Mycobacterium tuberculosis

<400>  3

Met Asn Leu Arg Arg His Gln Thr Leu Thr Leu Arg Leu Leu Ala Ala 
1               5                   10                  15      


Ser Ala Gly Ile Leu Ser Ala Ala Ala Phe Ala Ala Pro Ala Gln Ala 
            20                  25                  30          


Asn Pro Val Asp Asp Ala Phe Ile Ala Ala Leu Asn Asn Ala Gly Val 
        35                  40                  45              


Asn Tyr Gly Asp Pro Val Asp Ala Lys Ala Leu Gly Gln Ser Val Cys 
    50                  55                  60                  


Pro Ile Leu Ala Glu Pro Gly Gly Ser Phe Asn Thr Ala Val Ala Ser 
65                  70                  75                  80  


Val Val Ala Arg Ala Gln Gly Met Ser Gln Asp Met Ala Gln Thr Phe 
                85                  90                  95      


Thr Ser Ile Ala Ile Ser Met Tyr Cys Pro Ser Val Met Ala Asp Val 
            100                 105                 110         


Ala Ser Gly Asn Leu Pro Ala Leu Pro Asp Met Pro Gly Leu Pro Gly 
        115                 120                 125             


Ser 
    


<210>  4
<211>  390
<212>  DNA
<213>  Mycobacterium tuberculosis

<400>  4
atgaacctac ggcgccatca gaccctgacg ctgcgactgc tggcggcatc cgcgggcatt       60

ctcagcgccg cggccttcgc cgcgccagca caggcaaacc ccgtcgacga cgcgttcatc      120

gccgcgctga acaatgccgg cgtcaactac ggcgatccgg tcgacgccaa agcgctgggt      180

cagtccgtct gcccgatcct ggccgagccc ggcgggtcgt ttaacaccgc ggtagccagc      240

gttgtggcgc gcgcccaagg catgtcccag gacatggcgc aaaccttcac cagtatcgcg      300

atttcgatgt actgcccctc ggtgatggca gacgtcgcca gcggcaacct gccggccctg      360

ccagacatgc cggggctgcc cgggtcctag                                       390


<210>  5
<211>  262
<212>  PRT
<213>  Mycobacterium tuberculosis

<400>  5

Met Ser Ser Glu Ser Asp Ala Ala Asn Thr Glu Pro Glu Val Leu Val 
1               5                   10                  15      


Glu Gln Arg Asp Arg Ile Leu Ile Ile Thr Ile Asn Arg Pro Lys Ala 
            20                  25                  30          


Lys Asn Ala Val Asn Ala Ala Val Ser Arg Gly Leu Ala Asp Ala Met 
        35                  40                  45              


Asp Gln Leu Asp Gly Asp Ala Gly Leu Ser Val Ala Ile Leu Thr Gly 
    50                  55                  60                  


Gly Gly Gly Ser Phe Cys Ala Gly Met Asp Leu Lys Ala Phe Ala Arg 
65                  70                  75                  80  


Gly Glu Asn Val Val Val Glu Gly Arg Gly Leu Gly Phe Thr Glu Arg 
                85                  90                  95      


Pro Pro Thr Lys Pro Leu Ile Ala Ala Val Glu Gly Tyr Ala Leu Ala 
            100                 105                 110         


Gly Gly Thr Glu Leu Ala Leu Ala Ala Asp Leu Ile Val Ala Ala Arg 
        115                 120                 125             


Asp Ser Ala Phe Gly Ile Pro Glu Val Lys Arg Gly Leu Val Ala Gly 
    130                 135                 140                 


Gly Gly Gly Leu Leu Arg Leu Pro Glu Arg Ile Pro Tyr Ala Ile Ala 
145                 150                 155                 160 


Met Glu Leu Ala Leu Thr Gly Asp Asn Leu Pro Ala Glu Arg Ala His 
                165                 170                 175     


Glu Leu Gly Leu Val Asn Val Leu Ala Glu Pro Gly Thr Ala Leu Asp 
            180                 185                 190         


Ala Ala Ile Ala Leu Ala Glu Lys Ile Thr Ala Asn Gly Pro Leu Ala 
        195                 200                 205             


Val Val Ala Thr Lys Arg Ile Ile Thr Glu Ser Arg Gly Trp Ser Pro 
    210                 215                 220                 


Asp Thr Met Phe Ala Glu Gln Met Lys Ile Leu Val Pro Val Phe Thr 
225                 230                 235                 240 


Ser Asn Asp Ala Lys Glu Gly Ala Ile Ala Phe Ala Glu Arg Arg Arg 
                245                 250                 255     


Pro Arg Trp Thr Gly Thr 
            260         


<210>  6
<211>  789
<212>  DNA
<213>  Mycobacterium tuberculosis

<400>  6
atgagcagcg aaagcgacgc agccaacacc gaacctgagg ttctggtaga acagcgggat       60

cggattttga tcatcacgat caaccgcccg aaagccaaga acgcggtcaa cgccgcagtc      120

agccggggct tggccgatgc gatggatcag cttgacggcg atgccggcct gtcggtggca      180

atcctgaccg gtgggggcgg ttcgttctgc gcgggcatgg acctcaaggc gttcgcccgg      240

ggcgagaatg tcgtcgtcga aggtcgcggc cttggcttta ccgaacgtcc gccgaccaag      300

ccgctcattg ctgcggtgga aggctacgcg ttggcgggtg gcaccgagct ggcgcttgct      360

gccgacctga tcgtggcggc cagggattcg gcgttcggga ttcctgaagt caagcggggt      420

ctggttgccg gcggcggggg attgctgcgg ttgccggagc gcatcccgta tgcgatagcc      480

atggagttgg cgctgaccgg tgacaaccta ccggccgaac gcgcgcacga gctggggctc      540

gtcaacgttt tggccgagcc ggggaccgcc ctcgatgctg cgatcgcgtt ggcggagaag      600

atcaccgcca atgggccgct ggcggtggtg gccaccaagc ggattatcac cgagtcgcgt      660

gggtggagtc ccgacactat gttcgctgag cagatgaaga tcctggtgcc ggtgttcacc      720

tccaacgacg cgaaggaagg tgcgatcgcg ttcgccgaga ggcgccggcc ccgttggacg      780

ggcacctag                                                              789


<210>  7
<211>  186
<212>  PRT
<213>  Mycobacterium tuberculosis

<400>  7

Met Ser Asp Ala Leu Asp Glu Gly Leu Val Gln Arg Ile Asp Ala Arg 
1               5                   10                  15      


Gly Thr Ile Glu Trp Ser Glu Thr Cys Tyr Arg Tyr Thr Gly Ala His 
            20                  25                  30          


Arg Asp Ala Leu Ser Gly Glu Gly Ala Arg Arg Phe Gly Gly Arg Trp 
        35                  40                  45              


Asn Pro Pro Leu Leu Phe Pro Ala Ile Tyr Leu Ala Asp Ser Ala Gln 
    50                  55                  60                  


Ala Cys Met Val Glu Val Glu Arg Ala Ala Gln Ala Ala Ser Thr Thr 
65                  70                  75                  80  


Ala Glu Lys Met Leu Glu Ala Ala Tyr Arg Leu His Thr Ile Asp Val 
                85                  90                  95      


Thr Asp Leu Ala Val Leu Asp Leu Thr Thr Pro Gln Ala Arg Glu Ala 
            100                 105                 110         


Val Gly Leu Glu Asn Asp Asp Ile Tyr Gly Asp Asp Trp Ser Gly Cys 
        115                 120                 125             


Gln Ala Val Gly His Ala Ala Trp Phe Leu His Met Gln Gly Val Leu 
    130                 135                 140                 


Val Pro Ala Ala Gly Gly Val Gly Leu Val Val Thr Ala Tyr Glu Gln 
145                 150                 155                 160 


Arg Thr Arg Pro Gly Gln Leu Gln Leu Arg Gln Ser Val Asp Leu Thr 
                165                 170                 175     


Pro Ala Leu Tyr Gln Glu Leu Arg Ala Thr 
            180                 185     


<210>  8
<211>  561
<212>  DNA
<213>  Mycobacterium tuberculosis

<400>  8
gtgagcgatg ccctcgatga agggctcgtc cagcgtatcg acgcacgcgg aacaattgag       60

tggtcggaaa cgtgctaccg gtataccggc gcgcaccgtg acgccttgtc cggtgagggc      120

gcgcgcagat tcggaggcag gtggaatccg ccgctgctct ttccggcgat ctatcttgct      180

gattccgccc aagcctgcat ggttgaggtg gaacgggcgg cgcaagcggc ttcaacgacc      240

gcagagaaga tgctcgaggc ggcctaccga ctacacacga tcgacgtcac ggacctggcc      300

gtcctcgatc tgacaacccc gcaagctcgg gaagccgtgg ggctcgagaa cgacgacatc      360

tatggcgacg actggtcagg gtgccaggcg gtcggacatg cggcctggtt cttgcacatg      420

caaggtgtcc tcgtgccggc ggcgggcggt gtcggcctcg ttgtcaccgc gtatgaacag      480

cgaactcggc cgggccaact acaactgcga caaagcgtcg atctgacgcc tgctctttac      540

caagaacttc gagccacgta g                                                561


<210>  9
<211>  200
<212>  PRT
<213>  Mycobacterium tuberculosis

<400>  9

Met Ser Pro Ser Pro Ser Ala Leu Leu Ala Asp His Pro Asp Arg Ile 
1               5                   10                  15      


Arg Trp Asn Ala Lys Tyr Glu Cys Ala Asp Pro Thr Glu Ala Val Phe 
            20                  25                  30          


Ala Pro Ile Ser Trp Leu Gly Asp Val Leu Gln Phe Gly Val Pro Glu 
        35                  40                  45              


Gly Pro Val Leu Glu Leu Ala Cys Gly Arg Ser Gly Thr Ala Leu Gly 
    50                  55                  60                  


Leu Ala Ala Ala Gly Arg Cys Val Thr Ala Ile Asp Val Ser Asp Thr 
65                  70                  75                  80  


Ala Leu Val Gln Leu Glu Leu Glu Ala Thr Arg Arg Glu Leu Ala Asp 
                85                  90                  95      


Arg Leu Thr Leu Val His Ala Asp Leu Cys Ser Trp Gln Ser Gly Asp 
            100                 105                 110         


Gly Arg Phe Ala Leu Val Leu Cys Arg Leu Phe Trp His Pro Pro Thr 
        115                 120                 125             


Phe Arg Gln Ala Cys Glu Ala Val Ala Pro Gly Gly Val Val Ala Trp 
    130                 135                 140                 


Glu Ala Trp Arg Arg Pro Ile Asp Val Ala Arg Asp Thr Arg Arg Ala 
145                 150                 155                 160 


Glu Trp Cys Leu Lys Pro Gly Gln Pro Glu Ser Glu Leu Pro Ala Gly 
                165                 170                 175     


Phe Thr Val Ile Arg Val Val Asp Thr Asp Gly Ser Glu Pro Ser Arg 
            180                 185                 190         


Arg Ile Ile Ala Gln Arg Ser Leu 
        195                 200 


<210>  10
<211>  603
<212>  DNA
<213>  Mycobacterium tuberculosis

<400>  10
atgagtccgt ctccatcggc cctgctcgcc gaccacccgg accgcattcg ttggaacgcg       60

aaatacgagt gcgctgaccc cacggaggcg gtatttgcgc ccatatcctg gctcggcgac      120

gtgctgcagt tcggggtgcc agaagggccg gttctggaac tggcgtgcgg tcggtccggc      180

accgcgctgg ggctagccgc ggcgggccgc tgcgtgactg cgatcgacgt ttccgatacc      240

gcgttggttc agctcgagct cgaagcgacc cgacgggaat tggccgatcg cctcacactg      300

gtgcacgccg atctctgctc ctggcagtcg ggggatggac gctttgctct ggtactttgc      360

cgactattct ggcatccgcc cacttttcgc caggcttgcg aggctgtggc gccgggcggt      420

gtagtggcgt gggaggcatg gcggcggccc atcgatgtcg ctcgggatac ccgtcgagcc      480

gaatggtgct tgaagccagg ccagcccgag tctgaacttc ccgccggctt cacggtgatt      540

cgggtggtcg acaccgatgg ttcagagccg tcgcggcgca tcatcgccca acggtcactg      600

tga                                                                    603


<210>  11
<211>  100
<212>  PRT
<213>  Mycobacterium tuberculosis

<400>  11

Met Cys Ser Gly Pro Lys Gln Gly Leu Thr Leu Pro Ala Ser Val Asp 
1               5                   10                  15      


Leu Glu Lys Glu Thr Val Ile Thr Gly Arg Val Val Asp Gly Asp Gly 
            20                  25                  30          


Gln Ala Val Gly Gly Ala Phe Val Arg Leu Leu Asp Ser Ser Asp Glu 
        35                  40                  45              


Phe Thr Ala Glu Val Val Ala Ser Ala Thr Gly Asp Phe Arg Phe Phe 
    50                  55                  60                  


Ala Ala Pro Gly Ser Trp Thr Leu Arg Ala Leu Ser Ala Ala Gly Asn 
65                  70                  75                  80  


Gly Asp Ala Val Val Gln Pro Ser Gly Ala Gly Ile His Glu Val Asp 
                85                  90                  95      


Val Lys Ile Thr 
            100 


<210>  12
<211>  303
<212>  DNA
<213>  Mycobacterium tuberculosis

<400>  12
atgtgctctg gacccaagca aggactgaca ttgccggcca gcgtcgacct ggaaaaagaa       60

acggtgatca ccggccgcgt agtggacggt gacggccagg ccgtgggcgg cgcgttcgtg      120

cggctgctgg actcctccga cgagttcacc gcggaggtcg tcgcgtcggc caccggcgat      180

ttccggttct tcgccgcgcc cggatcctgg acgctgcgcg cgctgtcggc ggccggcaac      240

ggcgacgcgg tggtgcagcc ctcgggcgcg ggcatccacg aggtagacgt caagatcacc      300

tga                                                                    303


<210>  13
<211>  146
<212>  PRT
<213>  Mycobacterium tuberculosis

<400>  13

Met Ser Ala Tyr Lys Thr Val Val Val Gly Thr Asp Gly Ser Asp Ser 
1               5                   10                  15      


Ser Met Arg Ala Val Asp Arg Ala Ala Gln Ile Ala Gly Ala Asp Ala 
            20                  25                  30          


Lys Leu Ile Ile Ala Ser Ala Tyr Leu Pro Gln His Glu Asp Ala Arg 
        35                  40                  45              


Ala Ala Asp Ile Leu Lys Asp Glu Ser Tyr Lys Val Thr Gly Thr Ala 
    50                  55                  60                  


Pro Ile Tyr Glu Ile Leu His Asp Ala Lys Glu Arg Ala His Asn Ala 
65                  70                  75                  80  


Gly Ala Lys Asn Val Glu Glu Arg Pro Ile Val Gly Ala Pro Val Asp 
                85                  90                  95      


Ala Leu Val Asn Leu Ala Asp Glu Glu Lys Ala Asp Leu Leu Val Val 
            100                 105                 110         


Gly Asn Val Gly Leu Ser Thr Ile Ala Gly Arg Leu Leu Gly Ser Val 
        115                 120                 125             


Pro Ala Asn Val Ser Arg Arg Ala Lys Val Asp Val Leu Ile Val His 
    130                 135                 140                 


Thr Thr 
145     


<210>  14
<211>  441
<212>  DNA
<213>  Mycobacterium tuberculosis

<400>  14
atgagcgcct ataagaccgt ggtggtagga accgacggtt cggactcgtc gatgcgagcg       60

gtagatcgcg ctgcccagat cgccggcgca gacgccaagt tgatcatcgc ctcggcatac      120

ctacctcagc acgaggacgc tcgcgccgcc gacattctga aggacgaaag ctacaaggtg      180

acgggcaccg ccccgatcta cgagatcttg cacgacgcca aggaacgagc gcacaacgcc      240

ggtgcgaaaa acgtcgagga acggccgatc gtcggcgccc cggtcgacgc gttggtgaac      300

ctggccgatg aggagaaggc ggacctgctg gtcgtcggca atgtcggtct gagcacgatc      360

gcgggtcggc tgctcggatc ggtaccggcc aatgtgtcac gccgggccaa ggtcgacgtg      420

ctgatcgtgc acaccaccta g                                                441


<210>  15
<211>  232
<212>  PRT
<213>  Mycobacterium tuberculosis

<400>  15

Met His Leu Met Ile Pro Ala Glu Tyr Ile Ser Asn Val Ile Tyr Glu 
1               5                   10                  15      


Gly Pro Arg Ala Asp Ser Leu Tyr Ala Ala Asp Gln Arg Leu Arg Gln 
            20                  25                  30          


Leu Ala Asp Ser Val Arg Thr Thr Ala Glu Ser Leu Asn Thr Thr Leu 
        35                  40                  45              


Asp Glu Leu His Glu Asn Trp Lys Gly Ser Ser Ser Glu Trp Met Ala 
    50                  55                  60                  


Asp Ala Ala Leu Arg Tyr Leu Asp Trp Leu Ser Lys His Ser Arg Gln 
65                  70                  75                  80  


Ile Leu Arg Thr Ala Arg Val Ile Glu Ser Leu Val Met Ala Tyr Glu 
                85                  90                  95      


Glu Thr Leu Leu Arg Val Val Pro Pro Ala Thr Ile Ala Asn Asn Arg 
            100                 105                 110         


Glu Glu Val Arg Arg Leu Ile Ala Ser Asn Val Ala Gly Gly Lys His 
        115                 120                 125             


Ser Ser Asn Arg Arg Pro Arg Gly Thr Ile Arg Ala Val Pro Gly Arg 
    130                 135                 140                 


Lys Tyr Pro Ser Asn Gly Pro Leu Ser Lys Leu Asp Pro Ile Cys Ala 
145                 150                 155                 160 


Ile Glu Ala Ala Pro Met Ala Gly Ala Ala Ala Asp Pro Gln Glu Arg 
                165                 170                 175     


Val Gly Pro Arg Gly Arg Arg Gly Leu Ala Gly Gln Gln Gln Cys Arg 
            180                 185                 190         


Gly Arg Pro Gly Pro Ser Leu Arg Cys Ser His Asp Thr Pro Arg Phe 
        195                 200                 205             


Gln Met Asn Gln Ala Phe His Thr Met Val Asn Met Leu Leu Thr Cys 
    210                 215                 220                 


Phe Ala Cys Gln Glu Lys Pro Arg 
225                 230         


<210>  16
<211>  699
<212>  DNA
<213>  Mycobacterium tuberculosis

<400>  16
atgcatctaa tgatacccgc ggagtatatc tccaacgtaa tatatgaagg tccgcgtgct       60

gactcattgt atgccgccga ccagcgattg cgacaattag ctgactcagt tagaacgact      120

gccgagtcgc tcaacaccac gctcgacgag ctgcacgaga actggaaagg tagttcatcg      180

gaatggatgg ccgacgcggc tttgcggtat ctcgactggc tgtctaaaca ctcccgtcag      240

attttgcgaa ccgcccgcgt gatcgaatcc ctcgtaatgg cctatgagga gacacttctg      300

agggtggtac ccccggcgac tatcgccaac aaccgcgagg aggtgcgcag gctgatcgcg      360

agcaacgtgg ccgggggtaa acactccagc aatcgcagac ctcgaggcac aatacgagca      420

gtaccgggcc gaaaatatcc aagcaatgga ccgctatcta agttggaccc gatttgcgct      480

atcgaagctg ccccgatggc gggagccgcc gcagatccac aggagcgggt aggtccaaga      540

ggccggcgcg gtcttgcagg ccagcaacaa tgccgcggtc gaccaggccc atcgcttcgc      600

tgctcgcacg acacaccgcg gtttcagatg aatcaggcgt ttcacaccat ggtgaacatg      660

ttgctgacgt gttttgcatg tcaggagaaa ccgagatga                             699


