                         SEQUENCE LISTING

<110>  University of South Florida
       The Regents of the University of California
       The Texas A&M University System
       Weeber, Edwin John
       Segal, David J.
       O'Geen, Henriette
       Pyles, Benjamin
       Dindot, Scott V.
 
<120>  ANIMAL MODEL OF ANGELMAN SYNDROME

<130>  USF.380XPCT

<150>  62/403,463
<151>  2016-10-03

<160>  26    

<170>  PatentIn version 3.5

<210>  1
<211>  875
<212>  PRT
<213>  Homo sapiens

<400>  1

Met Glu Lys Leu His Gln Cys Tyr Trp Lys Ser Gly Glu Pro Gln Ser 
1               5                   10                  15      


Asp Asp Ile Glu Ala Ser Arg Met Lys Arg Ala Ala Ala Lys His Leu 
            20                  25                  30          


Ile Glu Arg Tyr Tyr His Gln Leu Thr Glu Gly Cys Gly Asn Glu Ala 
        35                  40                  45              


Cys Thr Asn Glu Phe Cys Ala Ser Cys Pro Thr Phe Leu Arg Met Asp 
    50                  55                  60                  


Asn Asn Ala Ala Ala Ile Lys Ala Leu Glu Leu Tyr Lys Ile Asn Ala 
65                  70                  75                  80  


Lys Leu Cys Asp Pro His Pro Ser Lys Lys Gly Ala Ser Ser Ala Tyr 
                85                  90                  95      


Leu Glu Asn Ser Lys Gly Ala Pro Asn Asn Ser Cys Ser Glu Ile Lys 
            100                 105                 110         


Met Asn Lys Lys Gly Ala Arg Ile Asp Phe Lys Asp Val Thr Tyr Leu 
        115                 120                 125             


Thr Glu Glu Lys Val Tyr Glu Ile Leu Glu Leu Cys Arg Glu Arg Glu 
    130                 135                 140                 


Asp Tyr Ser Pro Leu Ile Arg Val Ile Gly Arg Val Phe Ser Ser Ala 
145                 150                 155                 160 


Glu Ala Leu Val Gln Ser Phe Arg Lys Val Lys Gln His Thr Lys Glu 
                165                 170                 175     


Glu Leu Lys Ser Leu Gln Ala Lys Asp Glu Asp Lys Asp Glu Asp Glu 
            180                 185                 190         


Lys Glu Lys Ala Ala Cys Ser Ala Ala Ala Met Glu Glu Asp Ser Glu 
        195                 200                 205             


Ala Ser Ser Ser Arg Ile Gly Asp Ser Ser Gln Gly Asp Asn Asn Leu 
    210                 215                 220                 


Gln Lys Leu Gly Pro Asp Asp Val Ser Val Asp Ile Asp Ala Ile Arg 
225                 230                 235                 240 


Arg Val Tyr Thr Arg Leu Leu Ser Asn Glu Lys Ile Glu Thr Ala Phe 
                245                 250                 255     


Leu Asn Ala Leu Val Tyr Leu Ser Pro Asn Val Glu Cys Asp Leu Thr 
            260                 265                 270         


Tyr His Asn Val Tyr Ser Arg Asp Pro Asn Tyr Leu Asn Leu Phe Ile 
        275                 280                 285             


Ile Val Met Glu Asn Arg Asn Leu His Ser Pro Glu Tyr Leu Glu Met 
    290                 295                 300                 


Ala Leu Pro Leu Phe Cys Lys Ala Met Ser Lys Leu Pro Leu Ala Ala 
305                 310                 315                 320 


Gln Gly Lys Leu Ile Arg Leu Trp Ser Lys Tyr Asn Ala Asp Gln Ile 
                325                 330                 335     


Arg Arg Met Met Glu Thr Phe Gln Gln Leu Ile Thr Tyr Lys Val Ile 
            340                 345                 350         


Ser Asn Glu Phe Asn Ser Arg Asn Leu Val Asn Asp Asp Asp Ala Ile 
        355                 360                 365             


Val Ala Ala Ser Lys Cys Leu Lys Met Val Tyr Tyr Ala Asn Val Val 
    370                 375                 380                 


Gly Gly Glu Val Asp Thr Asn His Asn Glu Glu Asp Asp Glu Glu Pro 
385                 390                 395                 400 


Ile Pro Glu Ser Ser Glu Leu Thr Leu Gln Glu Leu Leu Gly Glu Glu 
                405                 410                 415     


Arg Arg Asn Lys Lys Gly Pro Arg Val Asp Pro Leu Glu Thr Glu Leu 
            420                 425                 430         


Gly Val Lys Thr Leu Asp Cys Arg Lys Pro Leu Ile Pro Phe Glu Glu 
        435                 440                 445             


Phe Ile Asn Glu Pro Leu Asn Glu Val Leu Glu Met Asp Lys Asp Tyr 
    450                 455                 460                 


Thr Phe Phe Lys Val Glu Thr Glu Asn Lys Phe Ser Phe Met Thr Cys 
465                 470                 475                 480 


Pro Phe Ile Leu Asn Ala Val Thr Lys Asn Leu Gly Leu Tyr Tyr Asp 
                485                 490                 495     


Asn Arg Ile Arg Met Tyr Ser Glu Arg Arg Ile Thr Val Leu Tyr Ser 
            500                 505                 510         


Leu Val Gln Gly Gln Gln Leu Asn Pro Tyr Leu Arg Leu Lys Val Arg 
        515                 520                 525             


Arg Asp His Ile Ile Asp Asp Ala Leu Val Arg Leu Glu Met Ile Ala 
    530                 535                 540                 


Met Glu Asn Pro Ala Asp Leu Lys Lys Gln Leu Tyr Val Glu Phe Glu 
545                 550                 555                 560 


Gly Glu Gln Gly Val Asp Glu Gly Gly Val Ser Lys Glu Phe Phe Gln 
                565                 570                 575     


Leu Val Val Glu Glu Ile Phe Asn Pro Asp Ile Gly Met Phe Thr Tyr 
            580                 585                 590         


Asp Glu Ser Thr Lys Leu Phe Trp Phe Asn Pro Ser Ser Phe Glu Thr 
        595                 600                 605             


Glu Gly Gln Phe Thr Leu Ile Gly Ile Val Leu Gly Leu Ala Ile Tyr 
    610                 615                 620                 


Asn Asn Cys Ile Leu Asp Val His Phe Pro Met Val Val Tyr Arg Lys 
625                 630                 635                 640 


Leu Met Gly Lys Lys Gly Thr Phe Arg Asp Leu Gly Asp Ser His Pro 
                645                 650                 655     


Val Leu Tyr Gln Ser Leu Lys Asp Leu Leu Glu Tyr Glu Gly Asn Val 
            660                 665                 670         


Glu Asp Asp Met Met Ile Thr Phe Gln Ile Ser Gln Thr Asp Leu Phe 
        675                 680                 685             


Gly Asn Pro Met Met Tyr Asp Leu Lys Glu Asn Gly Asp Lys Ile Pro 
    690                 695                 700                 


Ile Thr Asn Glu Asn Arg Lys Glu Phe Val Asn Leu Tyr Ser Asp Tyr 
705                 710                 715                 720 


Ile Leu Asn Lys Ser Val Glu Lys Gln Phe Lys Ala Phe Arg Arg Gly 
                725                 730                 735     


Phe His Met Val Thr Asn Glu Ser Pro Leu Lys Tyr Leu Phe Arg Pro 
            740                 745                 750         


Glu Glu Ile Glu Leu Leu Ile Cys Gly Ser Arg Asn Leu Asp Phe Gln 
        755                 760                 765             


Ala Leu Glu Glu Thr Thr Glu Tyr Asp Gly Gly Tyr Thr Arg Asp Ser 
    770                 775                 780                 


Val Leu Ile Arg Glu Phe Trp Glu Ile Val His Ser Phe Thr Asp Glu 
785                 790                 795                 800 


Gln Lys Arg Leu Phe Leu Gln Phe Thr Thr Gly Thr Asp Arg Ala Pro 
                805                 810                 815     


Val Gly Gly Leu Gly Lys Leu Lys Met Ile Ile Ala Lys Asn Gly Pro 
            820                 825                 830         


Asp Thr Glu Arg Leu Pro Thr Ser His Thr Cys Phe Asn Val Leu Leu 
        835                 840                 845             


Leu Pro Glu Tyr Ser Ser Lys Glu Lys Leu Lys Glu Arg Leu Leu Lys 
    850                 855                 860                 


Ala Ile Thr Tyr Ala Lys Gly Phe Gly Met Leu 
865                 870                 875 


<210>  2
<211>  4491
<212>  DNA
<213>  Homo sapiens

<400>  2
acagatcagg agaacctcag tctgacgaca ttgaagctag ccgaatgaag cgagcagctg       60

caaagcatct aatagaacgc tactaccacc agttaactga gggctgtgga aatgaagcct      120

gcacgaatga gttttgtgct tcctgtccaa cttttcttcg tatggataat aatgcagcag      180

ctattaaagc cctcgagctt tataagatta atgcaaaact ctgtgatcct catccctcca      240

agaaaggagc aagctcagct taccttgaga actcgaaagg tgcccccaac aactcctgct      300

ctgagataaa aatgaacaag aaaggcgcta gaattgattt taaagatgtg acttacttaa      360

cagaagagaa ggtatatgaa attcttgaat tatgtagaga aagagaggat tattcccctt      420

taatccgtgt tattggaaga gttttttcta gtgctgaggc attggtacag agcttccgga      480

aagttaaaca acacaccaag gaagaactga aatctcttca agcaaaagat gaagacaaag      540

atgaagatga aaaggaaaaa gctgcatgtt ctgctgctgc tatggaagaa gactcagaag      600

catcttcctc aaggataggt gatagctcac agggagacaa caatttgcaa aaattaggcc      660

ctgatgatgt gtctgtggat attgatgcca ttagaagggt ctacaccaga ttgctctcta      720

atgaaaaaat tgaaactgcc tttctcaatg cacttgtata tttgtcacct aacgtggaat      780

gtgacttgac gtatcacaat gtatactctc gagatcctaa ttatctgaat ttgttcatta      840

tcgtaatgga gaatagaaat ctccacagtc ctgaatatct ggaaatggct ttgccattat      900

tttgcaaagc gatgagcaag ctaccccttg cagcccaagg aaaactgatc agactgtggt      960

ctaaatacaa tgcagaccag attcggagaa tgatggagac atttcagcaa cttattactt     1020

ataaagtcat aagcaatgaa tttaacagtc gaaatctagt gaatgatgat gatgccattg     1080

ttgctgcttc gaagtgcttg aaaatggttt actatgcaaa tgtagtggga ggggaagtgg     1140

acacaaatca caatgaagaa gatgatgaag agcccatccc tgagtccagc gagctgacac     1200

ttcaggaact tttgggagaa gaaagaagaa acaagaaagg tcctcgagtg gaccccctgg     1260

aaactgaact tggtgttaaa accctggatt gtcgaaaacc acttatccct tttgaagagt     1320

ttattaatga accactgaat gaggttctag aaatggataa agattatact tttttcaaag     1380

tagaaacaga gaacaaattc tcttttatga catgtccctt tatattgaat gctgtcacaa     1440

agaatttggg attatattat gacaatagaa ttcgcatgta cagtgaacga agaatcactg     1500

ttctctacag cttagttcaa ggacagcagt tgaatccata tttgagactc aaagttagac     1560

gtgaccatat catagatgat gcacttgtcc ggctagagat gatcgctatg gaaaatcctg     1620

cagacttgaa gaagcagttg tatgtggaat ttgaaggaga acaaggagtt gatgagggag     1680

gtgtttccaa agaatttttt cagctggttg tggaggaaat cttcaatcca gatattggta     1740

tgttcacata cgatgaatct acaaaattgt tttggtttaa tccatcttct tttgaaactg     1800

agggtcagtt tactctgatt ggcatagtac tgggtctggc tatttacaat aactgtatac     1860

tggatgtaca ttttcccatg gttgtctaca ggaagctaat ggggaaaaaa ggaacttttc     1920

gtgacttggg agactctcac ccagttctat atcagagttt aaaagattta ttggagtatg     1980

aagggaatgt ggaagatgac atgatgatca ctttccagat atcacagaca gatctttttg     2040

gtaacccaat gatgtatgat ctaaaggaaa atggtgataa aattccaatt acaaatgaaa     2100

acaggaagga atttgtcaat ctttattctg actacattct caataaatca gtagaaaaac     2160

agttcaaggc ttttcggaga ggttttcata tggtgaccaa tgaatctccc ttaaagtact     2220

tattcagacc agaagaaatt gaattgctta tatgtggaag ccggaatcta gatttccaag     2280

cactagaaga aactacagaa tatgacggtg gctataccag ggactctgtt ctgattaggg     2340

agttctggga aatcgttcat tcatttacag atgaacagaa aagactcttc ttgcagttta     2400

caacgggcac agacagagca cctgtgggag gactaggaaa attaaagatg attatagcca     2460

aaaatggccc agacacagaa aggttaccta catctcatac ttgctttaat gtgcttttac     2520

ttccggaata ctcaagcaaa gaaaaactta aagagagatt gttgaaggcc atcacgtatg     2580

ccaaaggatt tggcatgctg taaaacaaaa caaaacaaaa taaaacaaaa aaaaggaagg     2640

aaaaaaaaag aaaaaattta aaaaatttta aaaatataac gagggataaa tttttggtgg     2700

tgatagtgtc ccagtacaaa aaggctgtaa gatagtcaac cacagtagtc acctatgtct     2760

gtgcctccct tctttattgg ggacatgtgg gctggaacag cagatttcag ctacatatat     2820

gaacaaatcc tttattatta ttataattat ttttttgcgt gaaagtgtta catattcttt     2880

cacttgtatg tacagagagg tttttctgaa tatttatttt aagggttaaa tcacttttgc     2940

ttgtgtttat tactgcttga ggttgagcct tttgagtatt taaaaaatat ataccaacag     3000

aactactctc ccaaggaaaa tattgccacc atttgtagac cacgtaacct tcaagtatgt     3060

gctacttttt tgtccctgta tctaactcaa atcaggaact gtattttttt taatgatttg     3120

cttttgaaac ttgaagtctt gaaaacagtg tgatgcaatt actgctgttc tagcccccaa     3180

agagttttct gtgcaaaatc ttgagaatca atcaataaag aaagatggaa ggaagggaga     3240

aattggaatg ttttaactgc agccctcaga actttagtaa cagcacaaca aattaaaaac     3300

aaaaacaact catgccacag tatgtcgtct tcatgtgtct tgcaatgaac tgtttcagta     3360

gccaatcctc tttcttagta tatgaaagga cagggatttt tgttcttgtt gttctcgttg     3420

ttgttttaag tttactgggg aaagtgcatt tggccaaatg aaatggtagt caagcctatt     3480

gcaacaaagt taggaagttt gttgtttgtt tattataaac aaaaagcatg tgaaagtgca     3540

cttaagatag agtttttatt aattacttac ttattaccta gattttaaat agacaatcca     3600

aagtctcccc ttcgtgttgc catcatcttg ttgaatcagc cattttatcg aggcacgtga     3660

tcagtgttgc aacataatga aaaagatggc tactgtgcct tgtgttactt aatcatacag     3720

taagctgacc tggaaatgaa tgaaactatt actcctaaga attacattgt atagccccac     3780

agattaaatt taattaatta attcaaaaca tgttaaacgt tactttcatg tactatggaa     3840

aagtacaagt aggtttacat tactgatttc cagaagtaag tagtttcccc tttcctagtc     3900

ttctgtgtat gtgatgttgt taatttcttt tattgcatta taaaataaaa ggattatgta     3960

tttttaacta aggtgagaca ttgatatatc cttttgctac aagctatagc taatgtgctg     4020

agcttgtgcc ttggtgattg attgattgat tgactgattg ttttaactga ttactgtaga     4080

tcaacctgat gatttgtttg tttgaaattg gcaggaaaaa tgcagctttc aaatcattgg     4140

ggggagaaaa aggatgtctt tcaggattat tttaattaat ttttttcata attgagacag     4200

aactgtttgt tatgtaccat aatgctaaat aaaactgtgg cacttttcac cataatttaa     4260

tttagtggaa aaagaagaca atgctttcca tattgtgata aggtaacatg gggtttttct     4320

gggccagcct ttagaacact gttagggtac atacgctacc ttgatgaaag ggaccttcgt     4380

gcaactgtag tcatcttaaa ggcttctcat ccactgtgct tcttaatgtg taattaaagt     4440

gaggagaaat taaatactct gagggcgttt tatataataa attcgtgaag a              4491


<210>  3
<211>  868
<212>  PRT
<213>  Rattus norvegicus

<400>  3

Met Ala Thr Ala Cys Lys Arg Ser Ser Gly Glu Ser Gln Ser Glu Asp 
1               5                   10                  15      


Ile Glu Ala Ser Arg Met Lys Arg Ala Ala Ala Lys His Leu Ile Glu 
            20                  25                  30          


Arg Tyr Tyr His Gln Leu Thr Glu Gly Cys Gly Asn Glu Ala Cys Thr 
        35                  40                  45              


Asn Glu Phe Cys Ala Ser Cys Pro Thr Phe Leu Arg Met Asp Asn Asn 
    50                  55                  60                  


Ala Ala Ala Ile Lys Ala Leu Glu Leu Tyr Lys Ile Asn Ala Lys Leu 
65                  70                  75                  80  


Cys Asp Pro His Pro Ser Lys Lys Gly Ala Ser Ser Ala Tyr Leu Glu 
                85                  90                  95      


Asn Ser Lys Gly Ala Ser Asn Asn Ser Glu Ile Lys Met Asn Lys Lys 
            100                 105                 110         


Glu Glu Phe Lys Glu Val Asp Tyr Leu Thr Glu Glu Lys Val Tyr Glu 
        115                 120                 125             


Ile Tyr Glu Phe Cys Arg Glu Arg Glu Asp Tyr Ser Pro Leu Ile Arg 
    130                 135                 140                 


Val Ile Gly Arg Ile Phe Ser Ser Ala Glu Ala Leu Val Gln Ser Phe 
145                 150                 155                 160 


Arg Lys Val Lys Gln His Thr Lys Glu Glu Leu Lys Ser Leu Gln Glu 
                165                 170                 175     


Lys Asp Glu Asp Lys Asp Glu Asp Glu Lys Glu Lys Ala Ala Cys Ser 
            180                 185                 190         


Ala Ala Ala Met Glu Glu Asp Ser Glu Ala Ser Ser Ser Arg Met Gly 
        195                 200                 205             


Asp Ser Ser Gln Gly Asp Asn Asn Val Gln Lys Leu Gly Pro Asp Asp 
    210                 215                 220                 


Val Thr Val Asp Ile Asp Ala Ile Arg Arg Val Tyr Ser Ser Leu Leu 
225                 230                 235                 240 


Ser Asp Glu Lys Ile Glu Thr Ala Phe Leu Asn Ala Leu Val Tyr Leu 
                245                 250                 255     


Ser Pro Asn Val Glu Cys Asp Leu Thr Tyr His Asn Val Tyr Thr Arg 
            260                 265                 270         


Asp Pro Asn Tyr Leu Asn Leu Phe Ile Ile Val Met Glu Asn Arg Asn 
        275                 280                 285             


Leu His Ser Pro Glu Tyr Leu Glu Met Ala Leu Pro Leu Phe Cys Lys 
    290                 295                 300                 


Ala Met Ser Lys Leu Pro Leu Ala Ala Gln Gly Lys Leu Ile Arg Leu 
305                 310                 315                 320 


Trp Ser Lys Tyr Ser Ala Asp Gln Ile Arg Arg Met Met Glu Thr Phe 
                325                 330                 335     


Gln Gln Leu Ile Thr Tyr Lys Val Ile Ser Asn Glu Phe Asn Ser Arg 
            340                 345                 350         


Asn Leu Val Asn Asp Asp Asp Ala Ile Val Ala Ala Ser Lys Cys Leu 
        355                 360                 365             


Lys Met Val Tyr Tyr Ala Asn Val Val Gly Gly Asp Val Asp Thr Asn 
    370                 375                 380                 


His Asn Glu Glu Asp Asp Glu Glu Pro Ile Pro Glu Ser Ser Glu Leu 
385                 390                 395                 400 


Thr Leu Gln Glu Leu Leu Gly Glu Glu Arg Arg Asn Lys Lys Gly Pro 
                405                 410                 415     


Arg Val Asp Pro Leu Glu Thr Glu Ile Gly Val Lys Thr Leu Asp Cys 
            420                 425                 430         


Arg Lys Pro Leu Ile Ser Phe Glu Glu Phe Ile Asn Glu Pro Leu Asn 
        435                 440                 445             


Asp Val Leu Glu Met Asp Lys Asp Tyr Thr Phe Phe Lys Val Glu Thr 
    450                 455                 460                 


Glu Asn Lys Phe Ser Phe Met Thr Cys Pro Phe Ile Leu Asn Ala Val 
465                 470                 475                 480 


Thr Lys Asn Leu Gly Leu Tyr Tyr Asp Asn Arg Ile Arg Met Tyr Ser 
                485                 490                 495     


Glu Arg Arg Ile Thr Val Leu Tyr Ser Leu Val Gln Gly Gln Gln Leu 
            500                 505                 510         


Asn Pro Tyr Leu Arg Leu Lys Val Arg Arg Asp His Ile Ile Asp Asp 
        515                 520                 525             


Ala Leu Val Arg Leu Glu Met Ile Ala Met Glu Asn Pro Ala Asp Leu 
    530                 535                 540                 


Lys Lys Gln Leu Tyr Val Glu Phe Glu Gly Glu Gln Gly Val Asp Glu 
545                 550                 555                 560 


Gly Gly Val Ser Lys Glu Phe Phe Gln Leu Val Val Glu Glu Ile Phe 
                565                 570                 575     


Asn Pro Asp Ile Gly Met Phe Thr Tyr Asp Glu Ala Thr Arg Leu Phe 
            580                 585                 590         


Trp Phe Asn Pro Ser Ser Phe Glu Thr Glu Gly Gln Phe Thr Leu Ile 
        595                 600                 605             


Gly Ile Val Leu Gly Leu Ala Ile Tyr Asn Asn Cys Ile Leu Asp Val 
    610                 615                 620                 


His Phe Pro Met Val Val Tyr Arg Lys Leu Met Gly Lys Lys Gly Thr 
625                 630                 635                 640 


Phe Cys Asp Leu Gly Asp Ser His Pro Ile Leu Tyr Gln Ser Leu Lys 
                645                 650                 655     


Asp Leu Leu Glu Tyr Glu Gly Asn Val Glu Asp Asp Met Met Ile Thr 
            660                 665                 670         


Phe Gln Ile Ser Gln Thr Asp Leu Phe Gly Asn Pro Met Met Tyr Asp 
        675                 680                 685             


Leu Lys Glu Asn Gly Asp Lys Ile Pro Ile Thr Asn Glu Asn Arg Lys 
    690                 695                 700                 


Glu Phe Val Ser Leu Tyr Ser Asp Tyr Ile Leu Asn Lys Ser Val Glu 
705                 710                 715                 720 


Lys Gln Phe Lys Ala Phe Arg Arg Gly Phe His Met Val Thr Asn Glu 
                725                 730                 735     


Ser Pro Leu Lys Tyr Leu Phe Arg Pro Glu Glu Ile Glu Leu Leu Ile 
            740                 745                 750         


Cys Gly Ser Arg Asn Leu Asp Phe Gln Ala Leu Glu Glu Thr Thr Glu 
        755                 760                 765             


Tyr Asp Gly Gly Tyr Thr Arg Glu Ser Val Val Ile Arg Glu Phe Trp 
    770                 775                 780                 


Glu Ile Val His Ser Phe Thr Asp Glu Gln Lys Arg Leu Phe Leu Gln 
785                 790                 795                 800 


Phe Thr Thr Gly Thr Asp Arg Ala Pro Val Gly Gly Leu Gly Lys Leu 
                805                 810                 815     


Lys Met Ile Ile Ala Lys Asn Gly Pro Asp Thr Glu Arg Leu Pro Thr 
            820                 825                 830         


Ser His Thr Cys Phe Asn Val Leu Leu Leu Pro Glu Tyr Ser Ser Lys 
        835                 840                 845             


Glu Lys Leu Lys Glu Arg Leu Leu Lys Ala Ile Thr Tyr Ala Lys Gly 
    850                 855                 860                 


Phe Gly Met Leu 
865             


<210>  4
<211>  5795
<212>  DNA
<213>  Rattus norvegicus

<400>  4
gtcgggatac tcggtccgcc cacctagtct tctcgtcctc gttcgcgaga tccgtgtttc       60

tcccaagatg gtggcgctcc tctttgggtg actacaggag acgacagggc ctttcgtctt      120

cgcaagtacc tcgccgcccc tcctgcgttc gctcgcgcac cgggccacgc agctgttcac      180

cgcctcatca cgactctcct cgttcgacca gtcgcggacg gtggcgcctc cttctgcttc      240

tcttcggagt tgctcgccac cctcgccccc caccgtggac agatcgcggc agcagccgtt      300

cagcgccgac ttcaaggttg cccaggcgcc cggcctcccg gcctcagttt cctgaggaga      360

agcgcgggtc ccgcatgaga cccggcggtg gcgccagcga aagggaacga ggcggtggcg      420

ggcggcggcg gtggacgagg gcgacaagga ccagtgaggc ggccgcagct gcgagggccg      480

cagcccacgc gcgggggcga ggacaggtta aaaatctgta agagcctgat tttagagttc      540

accagctcct cagaagtttg gcgaaatatg aattattaag cctacgttca gatcaagtta      600

gcagctagac tggtgtgaca acctgttttt aatcagtgac tcaaagctgt tatcaccctg      660

atgtcaccga atggccacag cttgtaaaag atcatcagga gaatcccagt ctgaggacat      720

tgaagctagc cgaatgaagc gagcagctgc aaagcatcta atagagcgct actaccatca      780

gttaactgag ggctgtggaa atgaggcctg cacgaatgag ttctgtgctt cctgtccaac      840

ttttcttcgt atggataaca atgcagcagc tattaaagct cttgagcttt ataaaattaa      900

tgcaaaactc tgtgatcctc atccctccaa gaaaggagca agctcagctt accttgagaa      960

ctcaaaaggt gcatctaaca actcagagat aaaaatgaac aagaaggaag agtttaaaga     1020

ggtggactac ctaactgaag agaaagtata tgaaatttat gaattttgta gggagagaga     1080

ggattactcc cctttaattc gtgtaattgg aagaatattt tctagtgctg aggcactggt     1140

tcagagcttt cggaaagtca aacagcacac taaggaggaa ttgaaatctc ttcaagagaa     1200

ggatgaagac aaggatgaag atgaaaagga aaaagctgcg tgttctgctg ctgctatgga     1260

agaagactca gaagcatctt cttcaaggat gggtgatagc tcacagggag acaacaatgt     1320

acaaaaatta ggtcctgatg atgtgactgt ggatattgat gctataagaa gggtctacag     1380

cagtttgctc tctgatgaaa aaatagaaac tgccttcctg aatgcacttg tatatctgtc     1440

acctaacgtg gaatgtgatt tgacatatca taatgtgtac actcgagacc ctaattatct     1500

caatttgttc attattgtaa tggaaaatag gaatctccac agtcctgaat atctggaaat     1560

ggcattgccg ttattttgca aagctatgag taagctaccc cttgcagctc aaggaaaact     1620

gattaggctg tggtctaaat acagtgctga ccagattcgg agaatgatgg aaacatttca     1680

gcaacttatt acctacaaag tcataagcaa tgaatttaat agccgaaatc tagtgaatga     1740

tgatgatgcc attgttgctg cttcaaagtg tttgaaaatg gtttactatg caaatgtagt     1800

gggaggggac gtggacacaa atcataatga ggaagatgat gaagagccta tacctgagtc     1860

cagtgaattg acacttcagg agcttctggg agaggaaaga agaaataaga aaggtcctcg     1920

agtggatcca ctagaaaccg aaattggcgt taaaactcta gattgtcgaa aaccacttat     1980

ctcctttgaa gaattcatta atgaaccact gaatgatgtt ctagaaatgg acaaagatta     2040

tacttttttc aaagttgaaa cagagaacaa attctctttt atgacatgtc cctttatatt     2100

gaatgctgtc acaaagaatc tgggattgta ttatgacaat agaattcgca tgtacagtga     2160

aagaagaatc actgttcttt acagcctagt tcaaggacag cagttgaatc catatttgag     2220

acttaaagtc agacgtgacc atattataga tgatgcactt gtccggctag agatgatcgc     2280

tatggaaaat cctgcagact tgaagaaaca gttgtatgtg gaatttgaag gagaacaagg     2340

agtagatgag ggaggcgttt ccaaagagtt ttttcagttg gttgtggagg aaatctttaa     2400

tccagatatt ggtatgttca catacgatga agctacaaga ttattttggt ttaatccatc     2460

ttcttttgaa actgagggtc aatttactct gattggcata gtcctgggtc tggctattta     2520

caataactgt atactggatg tccattttcc catggttgtg tacaggaagc taatggggaa     2580

aaaaggaacg ttttgtgact tgggagactc tcacccaatc ttatatcaga gtttaaagga     2640

tttattggaa tatgaaggga atgtggaaga tgatatgatg atcactttcc agatatcaca     2700

gacagatctt tttggtaacc caatgatgta tgatctaaaa gaaaatggtg ataaaattcc     2760

aattacaaat gaaaacagga aggaatttgt cagtctctat tcagactaca ttctcaataa     2820

atctgtagaa aaacaattca aggcatttcg cagaggtttt catatggtga ctaatgaatc     2880

acccttaaaa tacttattca gaccagaaga aattgaatta cttatatgtg gaagccggaa     2940

tctcgatttc caggcactag aagaaactac agagtatgat ggtggctata cgagagaatc     3000

tgttgtgatt agggagttct gggaaattgt tcattcgttt acagatgaac agaaaagact     3060

tttcctgcag tttacaacag gcacagacag agcacctgtt ggaggactcg gaaaattgaa     3120

gatgattata gccaaaaatg gcccagacac agaaaggtta cctacatctc atacttgctt     3180

taatgtcctt ttacttccgg aatattcaag caaagaaaaa cttaaagaga gattgctgaa     3240

ggccatcaca tatgccaaag gatttggcat gctgtaaaca aaacaaaaac aaaaagaaaa     3300

aaagaaaaaa gtcaaaaaac ttaataaata taagagggat aatttgatgg taatagtgtc     3360

ccagttcaaa aaggctgtaa gatagtgaac cacagtactc atctatgtct gtgcctccct     3420

tcttcattgg ggacattgtg ggctggaaca gcagatttca gctgcatata tgaacaaatc     3480

ctttattatt attataatta tttttttgcg tgaaagtgtt acatattctt tcacttgtat     3540

gtacagagag gtttttctga atatttattt taagggttaa atcacttttg cttgtgttta     3600

ttactgcttg aggttgagcc tttttgagta tttaaaatat atataccaac gaaactattc     3660

tcgcaaggaa aacattgcca ccatttgtag accatgtaat cttcaagtat gtgttttttt     3720

ttggccctgt atctaagtca aatcaggaac ttttttttaa ccatttgctt ttgaaacttg     3780

aagttaagga aacagtgtgg tgcaagtact gctgttctag cccccaagga gttttctgta     3840

caaaattttg agaatcaata aagatggaag ggagaatttg gaatgtttga accacagccc     3900

tcagaacttt agtaacagca caacaaatta aaacaactca tgccacagta cgttgtcttc     3960

atgtgtcttg caatgaactg tttcagtagc caatcctttt agtatatgaa aggacaggga     4020

tcttttttat tgttgttgtt gttgttgttg ttgttgttgt tgtttttgtt gtttaagttt     4080

actggggaaa gtgcatctgg ccaaatgata ggatagtcaa gcctattgca acaaaattag     4140

aaagtttgtt gtataaataa gcatgtaaaa gtgcacttaa aatgaatctt tattattccc     4200

gagattttaa atagacaatc caaagtctcc ccttctcttg ccatcatctt gtttaatcaa     4260

ctatttttca aggcactcga tcagtgttgc agcataatag aaagtccagc tactgtgcct     4320

tgtgttattt atttacacag taaacaggcc tggaaatgaa tggaactagt actcctgaga     4380

attaaattgt atatcctcca aattaaaatt tacttcaaaa gtgttaaaga attcatgtcc     4440

tatatataaa atacaaatag gcttagattg ctggacattt aatgtagttt cccatcccta     4500

gtcttttatg tttgtgatgt taatttcttt tgttgcataa caaaataaaa gaattatgta     4560

tttttaacta aggagagaca tactggtata tcattttact acaagctaca gatatcctgt     4620

tgagcttgtg ccttgattgt tttcacaact agtacaaatc aacctgatgt tttaaattgg     4680

cagggaataa ttaattgtag ctttcaaatc attggaaggg gaaaaggatg tcttttagga     4740

ttattttcct tcttgtagta gttgaggcag agctattatt tactgtaatg ctaaatgaaa     4800

cagtggctta aatactttaa tgggaaaaaa gaacacagtg cgttccatat tgtgataagg     4860

taatgtgagg tttttccttt tttttctgag ctagccttta gaacactgtt gtggtatgta     4920

tgctaccttg attataggac cccctaaatg tgactatagt catcataatg ggcatctagt     4980

ccactgtgct tcttatgtat tatgaaagtg ataagaagac aaattaagtg ggtatatttt     5040

ataaaataaa ttcatgaaga gatttgtgtt cttcagttct caagtttatt atcactacag     5100

tattgaagta gttgtgatac tatatctgtg tgaaagtttt gaaatggtaa tatagattat     5160

caaacagaag taacatcagt atatttaaaa gaaagtgaaa acaaataaac ctaaaatgtt     5220

ttcagaggta aaaatacatt ctcacttgct tcctagtcag tttttcttgg catgttgcca     5280

cattattatg gctgcctttt catcattgct tttctagatt gtcatggaac aatatttccg     5340

agttaaaaaa atacctcttg ctatagtaga acatttcaaa attacagcat aaaagcacag     5400

tctggagcaa aatttttctg gagacttggc agctgcagca aacaaattga gtgtctgtac     5460

atattgtggt ctataagtta attgtgtgat caaattcatt tgtaataacc ttacctttat     5520

ttggaagtac atccctgtgt aggaacgtat atatcaaaag aaacctataa atgagggttc     5580

agagaaccgg ttcatattga catgtggcac atgcatcact gggcagcatc actccctgtt     5640

tccataaggt ggctatgctg aaatcaacct cttaaagaat tattttctca agaatccata     5700

taacctagaa aaagaagtgt tttactgagg ctactctttc tgatgttcat cctttaactt     5760

cttatcccaa gacttatttt tatcctttct accct                                5795


<210>  5
<211>  872
<212>  PRT
<213>  Macaca mulatta

<400>  5

Met Ala Thr Ala Cys Lys Arg Ser Gly Glu Pro Gln Ser Asp Asp Ile 
1               5                   10                  15      


Glu Ala Ser Arg Met Lys Arg Ala Ala Ala Lys His Leu Ile Glu Arg 
            20                  25                  30          


Tyr Tyr His Gln Leu Thr Glu Gly Cys Gly Asn Glu Ala Cys Thr Asn 
        35                  40                  45              


Glu Phe Cys Ala Ser Cys Pro Thr Phe Leu Arg Met Asp Asn Asn Ala 
    50                  55                  60                  


Ala Ala Ile Lys Ala Leu Glu Leu Tyr Lys Ile Asn Ala Lys Leu Cys 
65                  70                  75                  80  


Asp Pro His Pro Ser Lys Lys Gly Ala Ser Ser Ala Tyr Leu Glu Asn 
                85                  90                  95      


Ser Lys Gly Ala Pro Asn Asn Ser Cys Ser Glu Ile Lys Met Asn Lys 
            100                 105                 110         


Lys Gly Thr Arg Ile Asp Phe Lys Asp Val Thr Tyr Leu Thr Glu Glu 
        115                 120                 125             


Lys Val Tyr Glu Ile Leu Glu Leu Cys Arg Glu Arg Glu Asp Tyr Ser 
    130                 135                 140                 


Pro Leu Ile Arg Val Ile Gly Arg Val Phe Ser Ser Ala Glu Ala Leu 
145                 150                 155                 160 


Val Gln Ser Phe Arg Lys Val Lys Gln His Thr Lys Glu Glu Leu Lys 
                165                 170                 175     


Ser Leu Gln Ala Lys Asp Glu Asp Lys Asp Glu Asp Glu Lys Glu Lys 
            180                 185                 190         


Ala Ala Cys Ser Ala Ala Ala Met Glu Glu Asp Ser Glu Ala Ser Ser 
        195                 200                 205             


Ser Arg Ile Gly Asp Ser Ser Gln Gly Asp Asn Asn Leu Gln Lys Val 
    210                 215                 220                 


Gly Pro Asp Asp Val Ser Val Asp Ile Asp Ala Ile Arg Arg Val Tyr 
225                 230                 235                 240 


Thr Arg Leu Leu Ser Asn Glu Lys Ile Glu Thr Ala Phe Leu Asn Ala 
                245                 250                 255     


Leu Val Tyr Leu Ser Pro Asn Val Glu Cys Asp Leu Thr Tyr His Asn 
            260                 265                 270         


Val Tyr Ser Arg Asp Pro Asn Tyr Leu Asn Leu Phe Ile Ile Val Met 
        275                 280                 285             


Glu Asn Arg Asn Leu His Ser Pro Glu Tyr Leu Glu Met Ala Leu Pro 
    290                 295                 300                 


Leu Phe Cys Lys Ala Met Ser Lys Leu Pro Leu Ala Ala Gln Gly Lys 
305                 310                 315                 320 


Leu Ile Arg Leu Trp Ser Lys Tyr Asn Ala Asp Gln Ile Arg Arg Met 
                325                 330                 335     


Met Glu Thr Phe Gln Gln Leu Ile Thr Tyr Lys Val Ile Ser Asn Glu 
            340                 345                 350         


Phe Asn Ser Arg Asn Leu Val Asn Asp Asp Asp Ala Ile Val Ala Ala 
        355                 360                 365             


Ser Lys Cys Leu Lys Met Val Tyr Tyr Ala Asn Val Val Gly Gly Glu 
    370                 375                 380                 


Val Asp Thr Asn His Asn Glu Glu Asp Asp Glu Glu Pro Ile Pro Glu 
385                 390                 395                 400 


Ser Ser Glu Leu Thr Leu Gln Glu Leu Leu Gly Glu Glu Arg Arg Asn 
                405                 410                 415     


Lys Lys Gly Pro Arg Val Asp Pro Leu Glu Thr Glu Leu Gly Val Lys 
            420                 425                 430         


Thr Leu Asp Cys Arg Lys Pro Leu Ile Pro Phe Glu Glu Phe Ile Asn 
        435                 440                 445             


Glu Pro Leu Asn Glu Val Leu Glu Met Asp Lys Asp Tyr Thr Phe Phe 
    450                 455                 460                 


Lys Val Glu Thr Glu Asn Lys Phe Ser Phe Met Thr Cys Pro Phe Ile 
465                 470                 475                 480 


Leu Asn Ala Val Thr Lys Asn Leu Gly Leu Tyr Tyr Asp Asn Arg Ile 
                485                 490                 495     


Arg Met Tyr Ser Glu Arg Arg Ile Thr Val Leu Tyr Ser Leu Val Gln 
            500                 505                 510         


Gly Gln Gln Leu Asn Pro Tyr Leu Arg Leu Lys Val Arg Arg Asp His 
        515                 520                 525             


Ile Ile Asp Asp Ala Leu Val Arg Leu Glu Met Ile Ala Met Glu Asn 
    530                 535                 540                 


Pro Ala Asp Leu Lys Lys Gln Leu Tyr Val Glu Phe Glu Gly Glu Gln 
545                 550                 555                 560 


Gly Val Asp Glu Gly Gly Val Ser Lys Glu Phe Phe Gln Leu Val Val 
                565                 570                 575     


Glu Glu Ile Phe Asn Pro Asp Ile Gly Met Phe Thr Tyr Asp Glu Ser 
            580                 585                 590         


Thr Lys Leu Phe Trp Phe Asn Pro Ser Ser Phe Glu Thr Glu Gly Gln 
        595                 600                 605             


Phe Thr Leu Ile Gly Ile Val Leu Gly Leu Ala Ile Tyr Asn Asn Cys 
    610                 615                 620                 


Ile Leu Asp Val His Phe Pro Met Val Val Tyr Arg Lys Leu Met Gly 
625                 630                 635                 640 


Lys Lys Gly Thr Phe Arg Asp Leu Gly Asp Ser His Pro Val Leu Tyr 
                645                 650                 655     


Gln Ser Leu Lys Asp Leu Leu Glu Tyr Glu Gly Asn Val Glu Asp Asp 
            660                 665                 670         


Met Met Ile Thr Phe Gln Ile Ser Gln Thr Asp Leu Phe Gly Asn Pro 
        675                 680                 685             


Met Met Tyr Asp Leu Lys Glu Asn Gly Asp Lys Ile Pro Ile Thr Asn 
    690                 695                 700                 


Glu Asn Arg Lys Glu Phe Val Asn Leu Tyr Ser Asp Tyr Ile Leu Asn 
705                 710                 715                 720 


Lys Ser Val Glu Lys Gln Phe Lys Ala Phe Arg Arg Gly Phe His Met 
                725                 730                 735     


Val Thr Asn Glu Ser Pro Leu Lys Tyr Leu Phe Arg Pro Glu Glu Ile 
            740                 745                 750         


Glu Leu Leu Ile Cys Gly Ser Arg Asn Leu Asp Phe Gln Ala Leu Glu 
        755                 760                 765             


Glu Thr Thr Glu Tyr Asp Gly Gly Tyr Thr Arg Asp Ser Val Leu Ile 
    770                 775                 780                 


Arg Glu Phe Trp Glu Ile Val His Ser Phe Thr Asp Glu Gln Lys Arg 
785                 790                 795                 800 


Leu Phe Leu Gln Phe Thr Thr Gly Thr Asp Arg Ala Pro Val Gly Gly 
                805                 810                 815     


Leu Gly Lys Leu Lys Met Ile Ile Ala Lys Asn Gly Pro Asp Thr Glu 
            820                 825                 830         


Arg Leu Pro Thr Ser His Thr Cys Phe Asn Val Leu Leu Leu Pro Glu 
        835                 840                 845             


Tyr Ser Ser Lys Glu Lys Leu Lys Glu Arg Leu Leu Lys Ala Ile Thr 
    850                 855                 860                 


Tyr Ala Lys Gly Phe Gly Met Leu 
865                 870         


<210>  6
<211>  2882
<212>  DNA
<213>  Macaca mulatta

<400>  6
gcggaggcgg cgggcgaggg cgacgacgac cagtgaggcg gccgccgcag cccaggcgcg       60

ggggcgacga caggttaaaa atctgtaaga gcctgatttt agaattcacc agctcctcag      120

aagtttggcg aaatatgagt tattaagcct acgctcagat caaggtagca gctagactgg      180

tgtgacaacc tgtttttaat cagtgactca aagctgtgat caccctgatg tcaccgaatg      240

gccacagctt gtaaaagatc aggagaacct cagtctgacg acattgaagc tagccgaatg      300

aagcgagcag ctgcaaagca tctaatagaa cgctactacc accagttaac tgagggctgt      360

ggaaatgaag cctgcacgaa tgagttttgt gcttcctgtc caacttttct tcgtatggat      420

aataatgcag cagctattaa agccctcgag ctttataaga ttaatgcaaa actctgtgat      480

cctcatccct ccaagaaagg agcaagctca gcttaccttg agaactcgaa aggtgccccc      540

aacaactcct gctctgagat aaaaatgaac aagaaaggca ctagaattga ttttaaagat      600

gtgacttact taacagaaga gaaggtatat gaaattcttg aattatgtag agaaagagag      660

gattattccc ctttaattcg tgttattgga agagtttttt ctagtgctga ggcattggta      720

cagagcttcc ggaaagttaa acaacatacc aaggaagaac tgaaatctct tcaagcaaaa      780

gatgaagaca aggatgaaga tgaaaaggaa aaagctgcat gttctgctgc tgctatggaa      840

gaagactcag aagcatcttc ctcaaggata ggtgatagct cacagggaga caacaatttg      900

cagaaagtag gccctgatga tgtgtctgtg gatattgatg ccattagaag ggtctacacc      960

agattgctgt ctaatgaaaa aattgaaact gcctttctca atgcacttgt atatttgtca     1020

cctaacgtgg aatgtgactt gacgtatcac aatgtatact ctcgagatcc taattatctg     1080

aatttgttca ttatcgtaat ggagaataga aatctccaca gtcctgaata tctggaaatg     1140

gctttgccat tattttgcaa agcaatgagc aagctacccc ttgcagccca aggaaaactg     1200

atcagactgt ggtctaaata caatgcagac cagattcgga gaatgatgga gacatttcag     1260

caacttatta cttacaaagt cataagcaat gaatttaaca gtcgaaatct agtgaacgat     1320

gatgatgcca ttgttgctgc ttcgaagtgc ttgaaaatgg tttactatgc aaatgtagtg     1380

ggaggggaag tggacacaaa tcacaatgaa gaagatgatg aagagcccat ccctgaatcc     1440

agtgagctga cacttcagga gcttttggga gaagaaagaa gaaacaagaa aggtcctcga     1500

gtggaccccc tggaaactga acttggtgtt aaaaccctgg attgtcgaaa accacttatc     1560

ccttttgaag agtttattaa tgaaccactg aatgaggttc tagaaatgga taaagattat     1620

acttttttca aagtagaaac agagaacaaa ttctctttta tgacatgtcc ctttatatta     1680

aatgctgtca caaagaattt gggattatat tatgacaata gaattcgcat gtacagtgaa     1740

cgaagaatca ctgttctcta cagcttagtt caaggacagc agttgaatcc atatttgaga     1800

ctcaaagtta gacgtgacca tatcatagat gatgcacttg tccggctaga gatgatcgct     1860

atggaaaatc ctgcagactt gaagaagcag ttgtatgtgg aatttgaagg agaacaagga     1920

gttgatgaag gaggtgtttc caaagaattt tttcagctgg ttgtggagga aatcttcaat     1980

ccagatattg gtatgttcac atacgatgaa tctacaaaat tgttttggtt taatccgtct     2040

tcttttgaaa ctgagggtca gtttactctg attggcatag tactgggtct ggctatttac     2100

aataactgta tactggatgt acattttccc atggttgtct acagaaagct aatggggaaa     2160

aaaggaactt ttcgtgactt gggagactct cacccagttc tgtatcagag tttaaaagat     2220

ttattggagt atgaagggaa tgtggaagac gacatgatga tcactttcca gatatcacag     2280

acagatcttt ttggtaaccc aatgatgtat gatctaaagg aaaatggtga taaaattcca     2340

attacaaatg aaaacaggaa ggaatttgtc aatctttatt ctgactacat tctcaataaa     2400

tcagtagaaa aacagttcaa ggcttttcgg agaggttttc atatggtgac caatgaatct     2460

cccttaaagt acttattcag accagaagaa attgaattgc ttatatgtgg aagccggaat     2520

ctagatttcc aagcattaga agaaactaca gaatatgacg gtggctatac cagggactct     2580

gttctgatta gggagttctg ggaaatcgtt cattcattta cagatgaaca gaaaagactc     2640

ttcttgcagt ttacaacggg cacagacaga gcacctgtgg gaggactagg aaaattaaag     2700

atgattatag ccaaaaatgg cccagacaca gaaaggttac ctacatctca tacttgcttt     2760

aatgtgcttt tacttccgga atattcaagc aaagaaaaac ttaaagagag attgttgaag     2820

gccatcacgt atgccaaagg atttggcatg ctgtaaaaca aaacaaaata aaacaaaaaa     2880

aa                                                                    2882


<210>  7
<211>  856
<212>  PRT
<213>  Xenopus tropicalis

<400>  7

Met Lys Arg Ala Ala Ala Lys His Leu Ile Glu Arg Tyr Tyr His Gln 
1               5                   10                  15      


Leu Thr Glu Gly Cys Gly Asn Glu Thr Cys Thr Asn Glu Phe Cys Ala 
            20                  25                  30          


Ser Cys Pro Thr Phe Leu Arg Met Asp Asn Asn Ala Ala Ala Ile Lys 
        35                  40                  45              


Ala Leu Glu Leu Tyr Lys Val Asn Ala Lys Leu Cys Asp Pro His Pro 
    50                  55                  60                  


Ser Lys Lys Gly Thr Ser Ser Ser Tyr Leu Glu Asn Asn Ser Lys Ser 
65                  70                  75                  80  


Ala His Asn Asn Ser Cys Thr Glu Arg Lys Met Asn Lys Lys Asp Leu 
                85                  90                  95      


His Gly Pro Arg Asp Asp Phe Lys Asp Val Thr Phe Leu Ser Glu Glu 
            100                 105                 110         


Lys Val Tyr Glu Ile Leu Glu Leu Cys Arg Glu Lys Glu Asp Tyr Ser 
        115                 120                 125             


Pro Leu Ile Arg Val Ile Gly Arg Val Phe Ser Ser Ala Glu Ala Leu 
    130                 135                 140                 


Val Gln Ser Phe Arg Lys Ala Lys His His Thr Lys Glu Glu Leu Lys 
145                 150                 155                 160 


Ser Leu Gln Glu Lys Asp Glu Asp Lys Asp Glu Asp Glu Lys Glu Lys 
                165                 170                 175     


Ala Ala Ser Ser Ala Ala Ala Met Glu Glu Asp Ser Gly Ala Ser Ser 
            180                 185                 190         


Ser Arg Leu Ser Asp Asn Ser Gln Gly Asp Asn Asn Ile Gln Lys Leu 
        195                 200                 205             


Gly Pro Glu Glu Val Ser Leu Asp Ile Glu Ala Val Arg Arg Val Tyr 
    210                 215                 220                 


His Arg Leu Leu Ser Asn Glu Lys Ile Glu Thr Ala Phe Leu Asn Ala 
225                 230                 235                 240 


Leu Val Tyr Leu Ser Pro Asn Val Glu Cys Asp Leu Thr Tyr His Asn 
                245                 250                 255     


Val Tyr Ser Arg Asp Pro Asn Tyr Leu Asn Leu Phe Ile Ile Val Met 
            260                 265                 270         


Glu Asn Gly Asn Leu His Ser Pro Glu Tyr Leu Glu Met Ala Leu Pro 
        275                 280                 285             


Leu Phe Cys Lys Ala Met Ser Lys Leu Pro Leu Ala Ala Gln Ala Lys 
    290                 295                 300                 


Leu Ile Arg Leu Trp Ser Lys Tyr Ser Ala Glu Gln Ile Arg Arg Met 
305                 310                 315                 320 


Met Glu Thr Phe Gln Gln Leu Ile Thr Tyr Lys Val Ile Ser Asn Glu 
                325                 330                 335     


Phe Asn Ser Arg Asn Leu Val Asn Asp Asp Asp Ala Ile Val Ala Ala 
            340                 345                 350         


Thr Lys Cys Leu Lys Met Val Tyr Tyr Ser Asn Val Val Gly Gly Glu 
        355                 360                 365             


Ile Glu Thr Asp His Asn Glu Glu Glu Asp Asp Glu Pro Val Pro Glu 
    370                 375                 380                 


Ser Ser Glu Leu Thr Leu Gln Glu Leu Leu Gly Glu Glu Arg Arg Asn 
385                 390                 395                 400 


Lys Lys Gly Pro Arg Val Asp Pro Leu Glu Thr Glu Leu Gly Val Lys 
                405                 410                 415     


Ser Ile Asp Cys Arg Lys Pro Leu Ile Pro Phe Glu Glu Phe Val Asn 
            420                 425                 430         


Glu Pro Leu Asn Asp Val Leu Glu Met Asp Lys Asp Tyr Thr Phe Phe 
        435                 440                 445             


Lys Val Glu Thr Glu Asn Lys Phe Ser Phe Met Thr Cys Pro Phe Ile 
    450                 455                 460                 


Leu Asn Ala Val Thr Lys Asn Leu Gly Leu Tyr Tyr Asp Asn Arg Ile 
465                 470                 475                 480 


Arg Met Tyr Ser Glu Arg Arg Ile Thr Val Leu Tyr Ser Leu Val Gln 
                485                 490                 495     


Gly Gln Gln Leu Asn Pro Tyr Leu Arg Leu Lys Val Arg Arg Asp His 
            500                 505                 510         


Ile Ile Asp Asp Ala Leu Val Arg Leu Glu Met Ile Ala Met Glu Asn 
        515                 520                 525             


Pro Ala Asp Leu Lys Lys Gln Leu Tyr Val Glu Phe Glu Gly Glu Gln 
    530                 535                 540                 


Gly Val Asp Glu Gly Gly Val Ser Lys Glu Phe Phe Gln Leu Val Val 
545                 550                 555                 560 


Glu Glu Ile Phe Asn Pro Asp Ile Gly Met Phe Thr Tyr Asp Glu Ser 
                565                 570                 575     


Thr Lys His Ser Trp Phe Asn Pro Ser Ser Phe Glu Thr Glu Gly Gln 
            580                 585                 590         


Phe Thr Leu Ile Gly Ile Val Leu Gly Leu Ala Ile Tyr Asn Asn Cys 
        595                 600                 605             


Ile Leu Asp Val His Phe Pro Met Val Val Tyr Arg Lys Leu Met Gly 
    610                 615                 620                 


Lys Lys Gly Thr Phe Arg Asp Leu Ala Asp Ser His Pro Val Leu Tyr 
625                 630                 635                 640 


Gln Ser Leu Lys Glu Leu Leu Glu Tyr Glu Gly Asn Val Glu Glu Asp 
                645                 650                 655     


Met Met Met Thr Phe Gln Ile Ser Gln Thr Asp Leu Phe Gly Asn Pro 
            660                 665                 670         


Leu Met His Asp Leu Lys Glu Asn Gly Asp Lys Ile Pro Ile Thr Asn 
        675                 680                 685             


Glu Asn Arg Lys Glu Phe Val Ser Leu Tyr Thr Asp Tyr Ile Leu Asn 
    690                 695                 700                 


Lys Ser Val Glu Lys Gln Phe Lys Ala Phe Arg Arg Gly Phe His Met 
705                 710                 715                 720 


Val Thr Asn Glu Ser Pro Leu Lys Tyr Leu Phe Arg Pro Glu Glu Ile 
                725                 730                 735     


Glu Leu Leu Ile Cys Gly Ser Arg Asn Leu Asp Phe Gln Ala Leu Lys 
            740                 745                 750         


Asp Thr Thr Glu Tyr Asp Gly Gly Tyr Thr Arg Asp Ser Asn Ile Ile 
        755                 760                 765             


Lys Glu Phe Trp Glu Ile Val Asn Ser Phe Thr Glu Glu Gln Lys Arg 
    770                 775                 780                 


Leu Phe Leu Gln Phe Thr Thr Gly Thr Asp Arg Ala Pro Val Gly Gly 
785                 790                 795                 800 


Leu Gly Lys Leu Lys Met Ile Ile Ala Lys Asn Gly Pro Asp Thr Asp 
                805                 810                 815     


Arg Leu Pro Thr Ser His Thr Cys Phe Asn Val Leu Leu Leu Pro Glu 
            820                 825                 830         


Tyr Ser Asn Lys Glu Lys Leu Lys Glu Arg Leu Leu Lys Ala Ile Thr 
        835                 840                 845             


Tyr Ala Lys Gly Phe Gly Met Leu 
    850                 855     


<210>  8
<211>  2948
<212>  DNA
<213>  Xenopus tropicalis

<400>  8
ctctcgcgag atgagacttt tgacgtcggg attagctgtc cggcaggggc caggaatctg       60

ggtattatcg gcgttgcggg acgtttaagc agcaatctgg gactgcgggc tgtgtttaaa      120

aattcgggtg tgttgggcgg tatgcagtag tgctgtggtt tagattgggg gtctcgcatg      180

agttccccgg acaagaggtg gcagcaggag agagagggag ccccggagcc cgaggagagg      240

aggaccaaca ccccccgcag cagcccggga cacagccctg aaggagacag atcaccagga      300

gacccttatt cagaaaatct agaaaatagc cgaatgaagc gagcagctgc aaagcatcta      360

atagaacgct actaccacca gttaactgag ggttgtggaa atgaaacctg cacgaatgaa      420

ttttgtgctt cctgtcccac ttttcttcgt atggataaca atgcagcagc cattaaggcc      480

ctcgagttat ataaggttaa tgcaaaactc tgtgatcctc atccctccaa gaaaggaaca      540

agctcatctt atctagagaa caattcgaaa agtgcccata acaactcctg cacagaaaga      600

aagatgaata agaaagacct tcatggaccc agagatgact ttaaagatgt cactttcctg      660

tctgaagaaa aagtgtatga aattcttgaa ttgtgtagag aaaaagagga ctactcgcct      720

ttaattcggg tgatcgggag agtattttcc agtgcagaag ctttggttca gagtttccga      780

aaagcaaagc accatacaaa ggaggagcta aaatccttgc aagaaaagga tgaagataag      840

gatgaagatg aaaaggaaaa agctgcatca tctgctgctg caatggaaga ggattctgga      900

gcatcatcct caaggttaag tgacaactca caaggagaca acaacataca gaaactaggc      960

cctgaagaag tgtctctaga tatagaagca gttcgacggg tgtatcacag gttactttct     1020

aatgagaaaa tagaaactgc ctttctgaat gcacttgtgt acctttctcc taatgtggaa     1080

tgtgacttaa cttatcataa tgtttattca cgagatccca actatctcaa tttgtttata     1140

atcgtcatgg agaatggtaa tctccatagt cctgaatacc tggaaatggc tttaccgttg     1200

ttttgcaaag caatgagtaa attgccatta gcagcgcaag caaagttgat ccgtctttgg     1260

tcaaagtaca gcgctgagca gattcgccga atgatggaaa catttcagca gcttataacc     1320

tataaagtta taagtaacga gttcaacagt cgaaatttag tcaatgatga tgatgctatt     1380

gttgcagcaa caaagtgctt aaaaatggtt tactattcaa atgttgttgg tggagagatt     1440

gaaactgacc ataatgaaga ggaagatgat gaacctgttc ctgagtccag tgagttaact     1500

ctgcaggagc tgctagggga agaacgaaga aacaaaaaag gccctcgagt agatcccctt     1560

gaaaccgaac ttggtgttaa aagcattgat tgcaggaaac ctctcatccc tttcgaggaa     1620

ttcgttaacg aaccactaaa tgatgttcta gaaatggaca aagattatac tttctttaaa     1680

gtagagactg aaaacaaatt ctcttttatg acttgcccct ttatcctgaa tgcagttaca     1740

aagaatcttg gtctgtatta tgacaacaga atccgcatgt acagtgaaag gcgaataact     1800

gttctgtata gtctagtgca aggacagcaa cttaacccct atttgaggct caaagtacgg     1860

cgagatcaca tcattgacga tgctcttgtt aggcttgaga tgattgccat ggaaaatcct     1920

gcagatttga agaagcaatt atatgtggaa tttgagggag aacaaggagt tgacgaagga     1980

ggtgtttcta aagagttttt ccaattagtt gttgaagaaa ttttcaaccc tgatattggt     2040

atgtttacgt atgatgagtc cactaaacac tcttggttca atccatcatc ttttgagaca     2100

gaaggacagt ttacacttat tggcattgtg ctgggccttg caatttacaa taattgcatt     2160

ctagatgtgc attttccaat ggttgtatat agaaaactaa tggggaaaaa aggaaccttc     2220

cgtgaccttg ctgattctca tcctgttctt tatcagagtt taaaagaatt gttggagtat     2280

gaaggcaatg ttgaagaaga tatgatgatg actttccaga tctctcagac tgacctcttt     2340

ggaaatcctt taatgcacga cttaaaggaa aatggagata aaatccccat tacaaatgag     2400

aacagaaagg aatttgtcag tctatacaca gactatattc taaataaatc agtggaaaag     2460

caatttaaag ccttcagaag gggctttcac atggttacca atgaatcgcc tctgaaatat     2520

ctgtttagac cagaggagat tgaacttctt atttgtggaa gtaggaattt agatttccaa     2580

gctctgaaag atactacgga atatgatggt ggctatacca gagattcaaa tataataaag     2640

gagttttggg aaattgtaaa ttctttcaca gaggaacaaa aaagattgtt cttgcaattt     2700

acaacaggca cggacagagc acctgtaggt gggctaggca aattaaagat gattatagcc     2760

aaaaacggcc ctgatacaga caggttacca acatctcata cttgctttaa tgtccttttg     2820

cttccggagt actcaaataa agagaaactg aaggagagat tgttaaaggc catcacttat     2880

gctaaggggt ttggtatgct ctaaaaacaa aggcaagcgt gctaaaaaaa aataaaaaaa     2940

aaaaaaaa                                                              2948


<210>  9
<211>  857
<212>  PRT
<213>  Danio rerio

<400>  9

Met Lys Arg Ala Ala Ala Lys His Leu Ile Glu Arg Tyr Tyr His Gln 
1               5                   10                  15      


Leu Thr Glu Gly Cys Gly Asn Glu Ala Cys Thr Asn Glu Ala Cys Gly 
            20                  25                  30          


Ser Ser Pro Gly Phe Gln Arg Met Asp Asn Asn Ala Ala Ala Ile Lys 
        35                  40                  45              


Ala Leu Glu Leu Tyr Lys Asn Asn Ala Lys Leu Cys Asp Pro His Pro 
    50                  55                  60                  


Ser Lys Lys Gly Ala Ser Ser Ala Phe Pro Glu Asn Ser Ala Lys Gly 
65                  70                  75                  80  


Ala His Asn Phe Ser Ala Cys Ser Asn Gly Lys Met Asn His Lys Asp 
                85                  90                  95      


Leu Pro Pro Thr Arg Glu Asp Phe Arg Asp Leu Asn Phe Leu Thr Glu 
            100                 105                 110         


Asp Lys Val Tyr Glu Ile Leu Ser Ile Cys Ser Glu Thr Glu Asp Tyr 
        115                 120                 125             


Ser Pro Leu Ile Arg Val Ile Gly Arg Val Phe Ser Ser Ala Glu Ser 
    130                 135                 140                 


Leu Val Gln Ser Phe Arg Lys Ala Lys Gln His Thr Lys Glu Glu Leu 
145                 150                 155                 160 


Lys Ser Leu Gln Ala Lys Asp Glu Asp Lys Asp Glu Asp Glu Lys Glu 
                165                 170                 175     


Thr Ala Ser Gly Ser Ser Thr Ala Met Glu Val Glu Pro Glu Ala Ser 
            180                 185                 190         


Ala Ser Ser Gly Asp Gly Ser Ser His Gly Glu Asn Asn Val Gln Lys 
        195                 200                 205             


Leu Gly Pro Val Glu Val Ser Val Asp Ile Asp Ala Val Arg Arg Val 
    210                 215                 220                 


Tyr Asp Arg Leu Leu Ser Asn Glu Lys Ile Glu Ala Ala Phe Leu Asn 
225                 230                 235                 240 


Ala Leu Val Tyr Leu Ser Pro Asn Val Glu Cys Asp Leu Thr Tyr His 
                245                 250                 255     


Asn Val Tyr Ala Ala Asp Pro Asn Tyr Leu Asn Val Phe Ile Ile Val 
            260                 265                 270         


Met Glu Asn Ser Asn Leu His Ser Pro Glu Tyr Leu Glu Ile Ala Leu 
        275                 280                 285             


Pro Gln Phe Cys Lys Ala Met Ser Lys Leu Pro Leu Pro Ala Leu Ala 
    290                 295                 300                 


Lys Leu Ala Arg Leu Trp Ser Gln Tyr Gly Val Asp Gln Ile Arg Arg 
305                 310                 315                 320 


Leu Val Glu Thr Phe Gln Gln Leu Ile Thr Tyr Thr Val Ile Ser Asn 
                325                 330                 335     


Glu Phe Ser Ser Asp Asn Leu Val Asn Glu Asp Asp Gly Val Val Ala 
            340                 345                 350         


Ala Thr Lys Cys Leu Lys Ile Val Tyr Tyr Ala Asn Val Leu Gly Gly 
        355                 360                 365             


Asp Leu Asp Thr Asp His Asn Glu Glu Asp Asp Asp Glu Pro Ile Pro 
    370                 375                 380                 


Glu Ser Ser Glu Leu Thr Leu Gln Glu Leu Leu Gly Glu Glu Arg Arg 
385                 390                 395                 400 


Asn Lys Lys Gly Pro Arg Val Asp Pro Leu Glu Thr Glu Met Gly Ile 
                405                 410                 415     


Arg Ala Ser Asp Cys Arg Lys Pro Leu Ile Pro Phe Glu Glu Phe Ile 
            420                 425                 430         


Asn Glu Pro Leu Asn Glu Val Leu Glu Met Asp Lys Asp Tyr Thr Phe 
        435                 440                 445             


Phe Lys Val Glu Thr Glu Ser Lys Phe Ser Phe Met Thr Cys Pro Phe 
    450                 455                 460                 


Ile Leu Asn Ala Val Thr Lys Asn Leu Gly Leu Tyr Tyr Asp Asn Arg 
465                 470                 475                 480 


Ile Arg Met Tyr Ser Glu Arg Arg Ile Thr Ala Leu Tyr Ser Leu Val 
                485                 490                 495     


Gln Gly Gln Gln Leu Asn Pro Tyr Leu Arg Leu Lys Val Arg Arg Asp 
            500                 505                 510         


His Ile Ile Asp Asp Ala Leu Val Arg Leu Glu Met Ile Ala Met Glu 
        515                 520                 525             


Asn Pro Ala Asp Leu Lys Lys Gln Leu Tyr Val Glu Phe Glu Gly Glu 
    530                 535                 540                 


Gln Gly Val Asp Glu Gly Gly Val Ser Lys Glu Phe Phe Gln Leu Val 
545                 550                 555                 560 


Val Glu Glu Ile Phe Asn Pro Asp Ile Gly Met Phe Thr Tyr Asp Glu 
                565                 570                 575     


Ser Thr Lys Leu Phe Trp Phe Asn Pro Ser Ser Phe Glu Asn Glu Gly 
            580                 585                 590         


Gln Phe Thr Leu Ile Gly Ile Val Leu Gly Leu Ala Ile Tyr Asn Asn 
        595                 600                 605             


Cys Ile Leu Asp Val His Phe Pro Met Val Ile Tyr Arg Lys Leu Met 
    610                 615                 620                 


Gly Lys Lys Gly Thr Phe Arg Asp Leu Ala Asp Ser His Pro Val Leu 
625                 630                 635                 640 


Phe Gln Ser Leu Lys Asp Leu Met Glu Tyr Glu Gly Asn Val Glu Glu 
                645                 650                 655     


Asp Met Met Ile Thr Phe Gln Ile Ser Gln Thr Asp Leu Phe Gly Asn 
            660                 665                 670         


Pro Leu Met Tyr Asp Leu Lys Glu Ser Gly Asp Lys Ile Pro Val Thr 
        675                 680                 685             


Asn Glu Asn Arg Lys Asp Phe Val Ala Leu Tyr Ala Glu Tyr Met Leu 
    690                 695                 700                 


Asn Lys Ser Val Glu Lys Gln Phe Lys Ala Phe Arg Arg Gly Phe His 
705                 710                 715                 720 


Met Val Thr Asn Glu Ser Pro Leu Lys Tyr Leu Phe Arg Pro Glu Glu 
                725                 730                 735     


Ile Glu Leu Leu Ile Cys Gly Ser Arg Asn Leu Asp Phe Gln Ala Leu 
            740                 745                 750         


Glu Glu Ser Thr Glu Tyr Asp Gly Gly Tyr Asn Lys Asp Ser Arg Ile 
        755                 760                 765             


Ile Arg Asp Phe Trp Glu Thr Val His Ser Phe Glu Gln Glu Lys Lys 
    770                 775                 780                 


Arg Leu Phe Leu Gln Phe Thr Thr Gly Thr Asp Arg Ala Pro Val Gly 
785                 790                 795                 800 


Gly Leu Gly Lys Leu Lys Met Ile Ile Ala Lys Asn Gly Pro Asp Ser 
                805                 810                 815     


Asp Arg Leu Pro Thr Ser His Thr Cys Phe Asn Val Leu Leu Leu Pro 
            820                 825                 830         


Glu Tyr Ser Thr Val Glu Lys Leu Lys Glu Arg Leu Leu Lys Ala Ile 
        835                 840                 845             


Thr Tyr Ala Lys Gly Phe Gly Met Leu 
    850                 855         


<210>  10
<211>  4093
<212>  DNA
<213>  Danio rerio

<400>  10
caagatggcc gcgaatattt tgtggagggg ttggagttga atacacgccg cactagaagc       60

gattgtgatg ttgagagacc agattcattc gtcagcatca gaacacctcc aaaagattgc      120

tacctgacaa cctttgggtc tctttgagtt cagaaccgta gaagagtgtg atattggaaa      180

ctttaaagca agtctaatga agcgagcggc tgcaaagcat ttaattgagc gctactacca      240

ccagttaaca gagggctgtg gaaatgaggc ctgcacgaat gaggcttgtg gctcttctcc      300

gggtttccag cgcatggata acaatgcagc agccatcaag gccctggagt tatataagaa      360

taatgccaaa ctgtgtgatc ctcatccctc taagaaagga gccagttcag ccttcccgga      420

gaacagtgcc aaaggagctc acaacttctc tgcttgcagc aacggaaaga tgaaccataa      480

ggacctgcca cccacaaggg aggactttag agatctgaat ttcttgactg aggataaggt      540

gtatgaaatc ctgagcatct gcagtgagac agaggactat tctcctctaa tccgtgttat      600

tggtcgggtt ttctcaagtg cagagagtct agtccagagt ttccgcaaag caaaacaaca      660

caccaaggaa gagctcaagt cccttcaggc caaggatgaa gacaaagatg aagatgagaa      720

agaaacggct tctggttcat ccacagcaat ggaggtggaa ccagaagctt cagcatcaag      780

tggagacggg tcatctcatg gggagaacaa cgtccaaaag ttgggtcctg tagaagtttc      840

tgtagacatt gatgctgtaa gaagagtgta cgacagatta ttatcgaatg agaagattga      900

ggcagctttc ctcaacgcgt tagtctattt gtcgcccaac gtagagtgtg acctcaccta      960

tcacaatgtg tacgccgctg accctaatta cctgaacgtc ttcatcattg tgatggagaa     1020

cagtaacctc cacagtcccg aatacttaga aatcgccttg ccacagttct gcaaggccat     1080

gagcaagcta cctcttccgg ctctggccaa gcttgcacgg ttgtggtcgc agtacggtgt     1140

ggaccagatc cgacgtttgg tcgagacttt ccagcagctt attacctaca cggtcatcag     1200

caacgagttc agcagtgata acctagtcaa tgaggatgat ggtgtggtgg cagccaccaa     1260

gtgcttgaaa atcgtctact atgcaaacgt gctgggcggc gacctagaca cggatcacaa     1320

tgaggaggac gacgatgaac cgatccctga gtcaagtgag ctgacgctgc aggagctgct     1380

gggagaggag agacgcaata aaaaaggccc tcgagtggat ccgctggaga cagaaatggg     1440

catccgtgcc tcggactgtc gaaaacccct catcccattc gaggagttca tcaatgaacc     1500

actcaatgag gtgctggaaa tggacaaaga ctataccttc ttcaaggtgg agacagagag     1560

caagttctcc tttatgacct gccctttcat acttaacgct gtgactaaga atctgggcct     1620

gtactacgac aaccggatcc gcatgtatag cgagcgcagg attactgccc tctatagttt     1680

ggtgcaagga cagcaactaa acccttatct gcgactcaaa gtgcgcagag accacatcat     1740

agacgatgct cttgtcaggt tggagatgat tgccatggaa aaccctgcag acttgaagaa     1800

gcaactgtat gtggagtttg agggtgagca aggagtagat gagggaggag tatccaaaga     1860

attctttcaa ctggtagtag aggagatctt caacccagat ataggcatgt ttacctatga     1920

tgaaagcaca aaacttttct ggttcaaccc ttcatcattt gagaatgaag gccagttcac     1980

tttgataggc atcgtcctgg gcctagctat ctacaataac tgcattctgg atgtgcattt     2040

ccctatggtg atttacagaa aactaatggg aaagaaagga acgtttcgag accttgcaga     2100

ctctcatccg gttctttttc agagtctgaa agatctcatg gagtatgaag gcaatgttga     2160

agaagacatg atgattacct tccagatctc gcaaacagac ctgtttggaa acccactaat     2220

gtacgattta aaggaaagcg gtgataaaat ccctgttacc aatgagaaca gaaaggattt     2280

tgtggcgctc tatgcagagt acatgctgaa caaaagtgtg gagaaacagt ttaaggcctt     2340

tagaagagga ttccacatgg tcactaatga gtctccactg aaatatctgt ttcgaccgga     2400

ggagattgag ctgcttatat gtggcagcag gaaccttgac ttccaagcac ttgaagagag     2460

caccgaatat gatggaggat acaacaaaga ctcgcgcatt attagggatt tctgggagac     2520

ggtgcactca tttgagcagg agaagaagag actgtttctc cagttcacca ctggcacaga     2580

tagagctcca gttggaggtt taggcaaact caagatgatt attgccaaaa atggtcccga     2640

ctcagacagg ttacccacct ctcatacctg cttcaacgtg ctgctcctcc ccgaatactc     2700

caccgtggag aaacttaaag agagactcct taaagccatc acttacgcca aaggcttcgg     2760

catgctctga ggctaaagaa ctcactctag ccctcagagg agaatcagct acatccacaa     2820

ctaatcgtaa atatcaagtt taaatgtaag gcaacatgaa atgggttcaa aatggggaag     2880

ttctggtgac cgtgtgcctg tgcctaaaaa gtagataaaa ccacactgga ctcatggctc     2940

tctctctttc tctgtctctc tctctctccc tcttatgtaa gtgttcaggt tcccattttt     3000

ttgtatgcac tgagatatag cgttatttat tttaagggat gaaatctctt gtcatgtctg     3060

ccaggaattc cacacttttg ttgcttcata gtcataaaaa caggagggac ggttggaagt     3120

tttcaacggc tgcaggactg atcaccaact aaacttaata aaacaagatc aaagggagga     3180

ggtggaactt tgttgtatta cggttgaact gtgaaagtgc acttaactct attcagaatg     3240

tctttgtttt atttttgatt tttttttgtc aacccttagg cttttctttt tagttttggc     3300

tcgtgcttca ttggtcttcc ctagttcgtt cacatttgcg gcaatgtttg aaaggtacag     3360

agcagcctca gtctcagttt ggcatccagg aatctgtatt tattgagaat ctgcattgtt     3420

tgtaatgccg tcgtgctgct cgtttatggc cagtgttctg catttcgctt cagattcgac     3480

tttttctctc cctcacacac aactgaccgg tttgctaaag atcacagtgg tgcactcctg     3540

ccgaaaacga gtagtgttat aaaggagaga tctcaacttc ctataaaact ctgtcagaag     3600

cttcctacta gtgtttgttt gttttgttat ctgtcttgtt ttaattcaag atggcagact     3660

tttagtccat gaatgctaat tgacggtgcc ccatgaagaa agcgttttag ttgcgctttt     3720

ttttttcttt gctctgcaca gtgtctggcc cgatacattt ggatgaaaat gaggggaaat     3780

tggcacaagt cgtaccacta tcttgtcgtg ccaaacagtt atgctgagaa tcgccgctcc     3840

ggttttgttc aggcgtagct ggaaatccag attagtgatg ccctgttcac tttttttttt     3900

tttgtttatt ttgtttttcc ttattccctc ttgcagatta aatgtgactg tggtttgatc     3960

cactgctgat ggcgctaaca taaaaggggg aaacagaact tgatattgag aatgacaaca     4020

tttgattgtt tcaagttatt cttaaataaa ttcaaaactg aaaaacaaaa aaaaaaaaaa     4080

aaaaaaaaaa aaa                                                        4093


<210>  11
<211>  20
<212>  DNA
<213>  Rattus norvegicus

<400>  11
ggccctgcag agatgcaatc                                                   20


<210>  12
<211>  17
<212>  DNA
<213>  Rattus norvegicus

<400>  12
ggagccctcc gccggca                                                      17


<210>  13
<211>  17
<212>  DNA
<213>  Rattus norvegicus

<400>  13
tacccttccc aggcccc                                                      17


<210>  14
<211>  20
<212>  DNA
<213>  Rattus norvegicus

<400>  14
gcatttctag tacatcatcc                                                   20


<210>  15
<211>  20
<212>  DNA
<213>  Artificial

<220>
<223>  Ub3aDelF1 forward primer

<400>  15
aacaccaagc ctctctcagc                                                   20


<210>  16
<211>  20
<212>  DNA
<213>  Artificial

<220>
<223>  Ub3aDelR1 reverse primer

<400>  16
accaggcctc aaaattgaca                                                   20


<210>  17
<211>  20
<212>  DNA
<213>  Artificial

<220>
<223>  Ub3aDelF2 forward primer

<400>  17
ctcccgagta caccgaagac                                                   20


<210>  18
<211>  20
<212>  DNA
<213>  Artificial

<220>
<223>  Ub3aDelR2 reverse primer

<400>  18
gggaacagca aaagacatgg                                                   20


<210>  19
<211>  22
<212>  DNA
<213>  Artificial

<220>
<223>  Ub3aDelSpcfcF3 forward primer

<400>  19
gtaccaagaa gtcacatggc tc                                                22


<210>  20
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>  Ub3aDelSpcfcR3 reverse primer

<400>  20
gcaggctgct attacactaa gga                                               23


<210>  21
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>  Ub3aDelSpcfcF4 forward primer

<400>  21
acatggctct aaaagagttc agg                                               23


<210>  22
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>  Ub3aDelSpcfcR4 reverse primer

<400>  22
gtgattcact agggatatgc agg                                               23


<210>  23
<211>  24
<212>  RNA
<213>  Rattus norvegicus

<400>  23
uugugauucu gaacaguucu uggg                                              24


<210>  24
<211>  22
<212>  RNA
<213>  Rattus norvegicus

<400>  24
agcacuguac uacuaggggc uc                                                22


<210>  25
<211>  67
<212>  DNA
<213>  Rattus norvegicus

<400>  25
ccaagagcga aggcgaacta gagtagggcc ctgcagagat taaataaatc ccaggccccc       60

cagaatt                                                                 67


<210>  26
<211>  67
<212>  DNA
<213>  Rattus norvegicus

<400>  26
ccaagagcga aggcgaacta gagtagggcc ccgcagaatt aaataattga tgatgatgat       60

gatgatg                                                                 67


