                         SEQUENCE LISTING

<110>  Secarna Pharmaceuticals GmbH & Co. KG
 
<120>  NOVEL APPROACH FOR TREATING CANCER

<130>  112366P1064PC

<150>  EP16002166.3
<151>  2016-10-07

<160>  146   

<170>  PatentIn version 3.5

<210>  1
<211>  13
<212>  DNA
<213>  Homo sapiens

<400>  1
ggattacgtc tcc                                                          13


<210>  2
<211>  13
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antisense_sequence_5-3_partially_with_phosphorothioate_linkages
       _ [*]_and_LNA_modifications_[+] (see Misc_Features)


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  LNA_modification

<220>
<221>  misc_feature
<222>  (1)..(13)
<223>  phosphorothioate_linkages

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  LNA_modification

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  LNA_modification

<400>  2
ggattacgtc tcc                                                          13


<210>  3
<211>  13
<212>  DNA
<213>  Homo sapiens

<400>  3
tagtttggcg aca                                                          13


<210>  4
<211>  13
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antisense_sequence_5-3_partially_with_phosphorothioate_linkages
       _ [*]_and_LNA_modifications_[+] (see Misc_Features)


<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  LNA_modification

<220>
<221>  misc_feature
<222>  (1)..(13)
<223>  phosphorothioate_linkages

<220>
<221>  misc_feature
<222>  (11)..(13)
<223>  LNA_modification

<400>  4
tagtttggcg aca                                                          13


<210>  5
<211>  14
<212>  DNA
<213>  Homo sapiens

<400>  5
agaagcgcgg ctgg                                                         14


<210>  6
<211>  14
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antisense_sequence_5-3_partially_with_phosphorothioate_linkages
       _ [*]_and_LNA_modifications_[+] (see Misc_Features)


<220>
<221>  misc_feature
<222>  (1)..(3)
<223>  LNA_modification

<220>
<221>  misc_feature
<222>  (1)..(14)
<223>  phosphorothioate_linkages

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  LNA_modification

<400>  6
agaagcgcgg ctgg                                                         14


<210>  7
<211>  14
<212>  DNA
<213>  Homo sapiens

<400>  7
taccaagtga gtcc                                                         14


<210>  8
<211>  14
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antisense_sequence_5-3_partially_with_phosphorothioate_linkages
       _ [*]_and_LNA_modifications_[+] (see Misc_Features)


<220>
<221>  misc_feature
<222>  (1)..(3)
<223>  LNA_modification

<220>
<221>  misc_feature
<222>  (1)..(14)
<223>  phosphorothioate_linkages

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  LNA_modification

<400>  8
taccaagtga gtcc                                                         14


<210>  9
<211>  14
<212>  DNA
<213>  Homo sapiens

<400>  9
gattacgtct cctc                                                         14


<210>  10
<211>  14
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antisense_sequence_5-3_partially_with_phosphorothioate_linkages
       _ [*]_and_LNA_modifications_[+] (see Misc_Features)


<220>
<221>  misc_feature
<222>  (1)..(3)
<223>  LNA_modification

<220>
<221>  misc_feature
<222>  (1)..(14)
<223>  phosphorothioate_linkages

<220>
<221>  misc_feature
<222>  (12)..(14)
<223>  LNA_modification

<400>  10
gattacgtct cctc                                                         14


<210>  11
<211>  14
<212>  DNA
<213>  Homo sapiens

<400>  11
ttcgccaggt tcca                                                         14


<210>  12
<211>  14
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antisense_sequence_5-3_partially_with_phosphorothioate_linkages
       _ [*]_and_LNA_modifications_[+] (see Misc_Features)


<220>
<221>  misc_feature
<222>  (1)..(3)
<223>  LNA_modification

<220>
<221>  misc_feature
<222>  (1)..(14)
<223>  phosphorothioate_linkages

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  LNA_modification

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  LNA_modification

<400>  12
ttcgccaggt tcca                                                         14


<210>  13
<211>  14
<212>  DNA
<213>  Homo sapiens

<400>  13
tttcgccagg ttcc                                                         14


<210>  14
<211>  14
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antisense_sequence_5-3_partially_with_phosphorothioate_linkages
       _ [*]_and_LNA_modifications_[+] (see Misc_Features)


<220>
<221>  misc_feature
<222>  (1)..(3)
<223>  LNA_modification

<220>
<221>  misc_feature
<222>  (1)..(14)
<223>  phosphorothioate_linkages

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  LNA_modification

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  LNA_modification

<400>  14
tttcgccagg ttcc                                                         14


<210>  15
<211>  14
<212>  DNA
<213>  Homo sapiens

<400>  15
ttagtttggc gaca                                                         14


<210>  16
<211>  14
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antisense_sequence_5-3_partially_with_phosphorothioate_linkages
       _ [*]_and_LNA_modifications_[+] (see Misc_Features)


<220>
<221>  misc_feature
<222>  (1)..(3)
<223>  LNA_modification

<220>
<221>  misc_feature
<222>  (1)..(14)
<223>  phosphorothioate_linkages

<220>
<221>  misc_feature
<222>  (12)..(14)
<223>  LNA_modification

<400>  16
ttagtttggc gaca                                                         14


<210>  17
<211>  14
<212>  DNA
<213>  Homo sapiens

<400>  17
gtggttacag cgat                                                         14


<210>  18
<211>  14
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antisense_sequence_5-3_partially_with_phosphorothioate_linkages
       _ [*]_and_LNA_modifications_[+] (see Misc_Features)


<220>
<221>  misc_feature
<222>  (1)..(3)
<223>  LNA_modification

<220>
<221>  misc_feature
<222>  (1)..(14)
<223>  phosphorothioate_linkages

<220>
<221>  misc_feature
<222>  (12)..(14)
<223>  LNA_modification

<400>  18
gtggttacag cgat                                                         14


<210>  19
<211>  14
<212>  DNA
<213>  Homo sapiens

<400>  19
aggactagat tgac                                                         14


<210>  20
<211>  14
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antisense_sequence_5-3_partially_with_phosphorothioate_linkages
       _ [*]_and_LNA_modifications_[+] (see Misc_Features)


<220>
<221>  misc_feature
<222>  (1)..(3)
<223>  LNA_modification

<220>
<221>  misc_feature
<222>  (1)..(14)
<223>  phosphorothioate_linkages

<220>
<221>  misc_feature
<222>  (12)..(14)
<223>  LNA_modification

<400>  20
aggactagat tgac                                                         14


<210>  21
<211>  14
<212>  DNA
<213>  Homo sapiens

<400>  21
tcaagcacaa cgaa                                                         14


<210>  22
<211>  14
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antisense_sequence_5-3_partially_with_phosphorothioate_linkages
       _ [*]_and_LNA_modifications_[+] (see Misc_Features)


<220>
<221>  misc_feature
<222>  (1)..(3)
<223>  LNA_modification

<220>
<221>  misc_feature
<222>  (1)..(14)
<223>  phosphorothioate_linkages

<220>
<221>  misc_feature
<222>  (12)..(14)
<223>  LNA_modification

<400>  22
tcaagcacaa cgaa                                                         14


<210>  23
<211>  14
<212>  DNA
<213>  Homo sapiens

<400>  23
gagtagacta tgtg                                                         14


<210>  24
<211>  14
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antisense_sequence_5-3_partially_with_phosphorothioate_linkages
       _ [*]_and_LNA_modifications_[+] (see Misc_Features)


<220>
<221>  misc_feature
<222>  (1)..(3)
<223>  LNA_modification

<220>
<221>  misc_feature
<222>  (1)..(14)
<223>  phosphorothioate_linkages

<220>
<221>  misc_feature
<222>  (12)..(14)
<223>  LNA_modification

<400>  24
gagtagacta tgtg                                                         14


<210>  25
<211>  15
<212>  DNA
<213>  Homo sapiens

<400>  25
tggtgcggag cctcg                                                        15


<210>  26
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antisense_sequence_5-3_partially_with_phosphorothioate_linkages
       _ [*]_and_LNA_modifications_[+] (see Misc_Features)


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  LNA_modification

<220>
<221>  misc_feature
<222>  (1)..(15)
<223>  phosphorothioate_linkages

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  LNA_modification

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  LNA_modification

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  LNA_modification

<400>  26
tggtgcggag cctcg                                                        15


<210>  27
<211>  15
<212>  DNA
<213>  Homo sapiens

<400>  27
gttgtgttga ttctc                                                        15


<210>  28
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antisense_sequence_5-3_partially_with_phosphorothioate_linkages
       _ [*]_and_LNA_modifications_[+] (see Misc_Features)


<220>
<221>  misc_feature
<222>  (1)..(3)
<223>  LNA_modification

<220>
<221>  misc_feature
<222>  (1)..(15)
<223>  phosphorothioate_linkages

<220>
<221>  misc_feature
<222>  (13)..(15)
<223>  LNA_modification

<400>  28
gttgtgttga ttctc                                                        15


<210>  29
<211>  15
<212>  DNA
<213>  Homo sapiens

<400>  29
gaccaattca gctgt                                                        15


<210>  30
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antisense_sequence_5-3_partially_with_phosphorothioate_linkages
       _ [*]_and_LNA_modifications_[+] (see Misc_Features)


<220>
<221>  misc_feature
<222>  (1)..(3)
<223>  LNA_modification

<220>
<221>  misc_feature
<222>  (1)..(15)
<223>  phosphorothioate_linkages

<220>
<221>  misc_feature
<222>  (13)..(15)
<223>  LNA_modification

<400>  30
gaccaattca gctgt                                                        15


<210>  31
<211>  15
<212>  DNA
<213>  Homo sapiens

<400>  31
ttaccaagtg agtcc                                                        15


<210>  32
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antisense_sequence_5-3_partially_with_phosphorothioate_linkages
       _ [*]_and_LNA_modifications_[+] (see Misc_Features)


<220>
<221>  misc_feature
<222>  (1)..(3)
<223>  LNA_modification

<220>
<221>  misc_feature
<222>  (1)..(15)
<223>  phosphorothioate_linkages

<220>
<221>  misc_feature
<222>  (13)..(15)
<223>  LNA_modification

<400>  32
ttaccaagtg agtcc                                                        15


<210>  33
<211>  15
<212>  DNA
<213>  Homo sapiens

<400>  33
tgtcagtgct acacc                                                        15


<210>  34
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antisense_sequence_5-3_partially_with_phosphorothioate_linkages
       _ [*]_and_LNA_modifications_[+] (see Misc_Features)


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  LNA_modification

<220>
<221>  misc_feature
<222>  (1)..(15)
<223>  phosphorothioate_linkages

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  LNA_modification

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  LNA_modification

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  LNA_modification

<400>  34
tgtcagtgct acacc                                                        15


<210>  35
<211>  15
<212>  DNA
<213>  Homo sapiens

<400>  35
attacgtctc ctcca                                                        15


<210>  36
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antisense_sequence_5-3_partially_with_phosphorothioate_linkages
       _ [*]_and_LNA_modifications_[+] (see Misc_Features)


<220>
<221>  misc_feature
<222>  (1)..(3)
<223>  LNA_modification

<220>
<221>  misc_feature
<222>  (1)..(15)
<223>  phosphorothioate_linkages

<220>
<221>  misc_feature
<222>  (13)..(15)
<223>  LNA_modification

<400>  36
attacgtctc ctcca                                                        15


<210>  37
<211>  15
<212>  DNA
<213>  Homo sapiens

<400>  37
tcgccaggtt ccatt                                                        15


<210>  38
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antisense_sequence_5-3_partially_with_phosphorothioate_linkages
       _ [*]_and_LNA_modifications_[+] (see Misc_Features)


<220>
<221>  misc_feature
<222>  (1)..(3)
<223>  LNA_modification

<220>
<221>  misc_feature
<222>  (1)..(15)
<223>  phosphorothioate_linkages

<220>
<221>  misc_feature
<222>  (13)..(15)
<223>  LNA_modification

<400>  38
tcgccaggtt ccatt                                                        15


<210>  39
<211>  15
<212>  DNA
<213>  Homo sapiens

<400>  39
ggattctcaa cccgt                                                        15


<210>  40
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antisense_sequence_5-3_partially_with_phosphorothioate_linkages
       _ [*]_and_LNA_modifications_[+] (see Misc_Features)


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  LNA_modification

<220>
<221>  misc_feature
<222>  (1)..(15)
<223>  phosphorothioate_linkages

<220>
<221>  misc_feature
<222>  (13)..(15)
<223>  LNA_modification

<400>  40
ggattctcaa cccgt                                                        15


<210>  41
<211>  15
<212>  DNA
<213>  Homo sapiens

<400>  41
tttagtttgg cgaca                                                        15


<210>  42
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antisense_sequence_5-3_partially_with_phosphorothioate_linkages
       _ [*]_and_LNA_modifications_[+] (see Misc_Features)


<220>
<221>  misc_feature
<222>  (1)..(3)
<223>  LNA_modification

<220>
<221>  misc_feature
<222>  (1)..(15)
<223>  phosphorothioate_linkages

<220>
<221>  misc_feature
<222>  (13)..(15)
<223>  LNA_modification

<400>  42
tttagtttgg cgaca                                                        15


<210>  43
<211>  15
<212>  DNA
<213>  Homo sapiens

<400>  43
agttatagag gagac                                                        15


<210>  44
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antisense_sequence_5-3_partially_with_phosphorothioate_linkages
       _ [*]_and_LNA_modifications_[+] (see Misc_Features)


<220>
<221>  misc_feature
<222>  (1)..(3)
<223>  LNA_modification

<220>
<221>  misc_feature
<222>  (1)..(15)
<223>  phosphorothioate_linkages

<220>
<221>  misc_feature
<222>  (13)..(15)
<223>  LNA_modification

<400>  44
agttatagag gagac                                                        15


<210>  45
<211>  15
<212>  DNA
<213>  Homo sapiens

<400>  45
ggtggttaca gcgat                                                        15


<210>  46
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antisense_sequence_5-3_partially_with_phosphorothioate_linkages
       _ [*]_and_LNA_modifications_[+] (see Misc_Features)


<220>
<221>  misc_feature
<222>  (1)..(3)
<223>  LNA_modification

<220>
<221>  misc_feature
<222>  (1)..(15)
<223>  phosphorothioate_linkages

<220>
<221>  misc_feature
<222>  (13)..(15)
<223>  LNA_modification

<400>  46
ggtggttaca gcgat                                                        15


<210>  47
<211>  15
<212>  DNA
<213>  Homo sapiens

<400>  47
ccttatgcta tgaca                                                        15


<210>  48
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antisense_sequence_5-3_partially_with_phosphorothioate_linkages
       _ [*]_and_LNA_modifications_[+] (see Misc_Features)


<220>
<221>  misc_feature
<222>  (1)..(3)
<223>  LNA_modification

<220>
<221>  misc_feature
<222>  (1)..(15)
<223>  phosphorothioate_linkages

<220>
<221>  misc_feature
<222>  (13)..(15)
<223>  LNA_modification

<400>  48
ccttatgcta tgaca                                                        15


<210>  49
<211>  15
<212>  DNA
<213>  Homo sapiens

<400>  49
ggactagatt gactc                                                        15


<210>  50
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antisense_sequence_5-3_partially_with_phosphorothioate_linkages
       _ [*]_and_LNA_modifications_[+] (see Misc_Features)


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  LNA_modification

<220>
<221>  misc_feature
<222>  (1)..(15)
<223>  phosphorothioate_linkages

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  LNA_modification

<220>
<221>  misc_feature
<222>  (13)..(15)
<223>  LNA_modification

<400>  50
ggactagatt gactc                                                        15


<210>  51
<211>  15
<212>  DNA
<213>  Homo sapiens

<400>  51
tagcagtcaa ggtac                                                        15


<210>  52
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antisense_sequence_5-3_partially_with_phosphorothioate_linkages
       _ [*]_and_LNA_modifications_[+] (see Misc_Features)


<220>
<221>  misc_feature
<222>  (1)..(3)
<223>  LNA_modification

<220>
<221>  misc_feature
<222>  (1)..(15)
<223>  phosphorothioate_linkages

<220>
<221>  misc_feature
<222>  (13)..(15)
<223>  LNA_modification

<400>  52
tagcagtcaa ggtac                                                        15


<210>  53
<211>  15
<212>  DNA
<213>  Homo sapiens

<400>  53
cgaatgaggc ttttc                                                        15


<210>  54
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antisense_sequence_5-3_partially_with_phosphorothioate_linkages
       _ [*]_and_LNA_modifications_[+] (see Misc_Features)


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  LNA_modification

<220>
<221>  misc_feature
<222>  (1)..(15)
<223>  phosphorothioate_linkages

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  LNA_modification

<220>
<221>  misc_feature
<222>  (13)..(15)
<223>  LNA_modification

<400>  54
cgaatgaggc ttttc                                                        15


<210>  55
<211>  15
<212>  DNA
<213>  Homo sapiens

<400>  55
ctgtgtagtg atgac                                                        15


<210>  56
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antisense_sequence_5-3_partially_with_phosphorothioate_linkages
       _ [*]_and_LNA_modifications_[+] (see Misc_Features)


<220>
<221>  misc_feature
<222>  (1)..(3)
<223>  LNA_modification

<220>
<221>  misc_feature
<222>  (1)..(15)
<223>  phosphorothioate_linkages

<220>
<221>  misc_feature
<222>  (13)..(15)
<223>  LNA_modification

<400>  56
ctgtgtagtg atgac                                                        15


<210>  57
<211>  15
<212>  DNA
<213>  Homo sapiens

<400>  57
gactatgtgc cttgc                                                        15


<210>  58
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antisense_sequence_5-3_partially_with_phosphorothioate_linkages
       _ [*]_and_LNA_modifications_[+] (see Misc_Features)


<220>
<221>  misc_feature
<222>  (1)..(3)
<223>  LNA_modification

<220>
<221>  misc_feature
<222>  (1)..(15)
<223>  phosphorothioate_linkages

<220>
<221>  misc_feature
<222>  (13)..(15)
<223>  LNA_modification

<400>  58
gactatgtgc cttgc                                                        15


<210>  59
<211>  15
<212>  DNA
<213>  Homo sapiens

<400>  59
gataaagtgc cttac                                                        15


<210>  60
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antisense_sequence_5-3_partially_with_phosphorothioate_linkages
       _ [*]_and_LNA_modifications_[+] (see Misc_Features)


<220>
<221>  misc_feature
<222>  (1)..(3)
<223>  LNA_modification

<220>
<221>  misc_feature
<222>  (1)..(15)
<223>  phosphorothioate_linkages

<220>
<221>  misc_feature
<222>  (13)..(15)
<223>  LNA_modification

<400>  60
gataaagtgc cttac                                                        15


<210>  61
<211>  15
<212>  DNA
<213>  Homo sapiens

<400>  61
cctatgccat ttacg                                                        15


<210>  62
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antisense_sequence_5-3_partially_with_phosphorothioate_linkages
       _ [*]_and_LNA_modifications_[+] (see Misc_Features)


<220>
<221>  misc_feature
<222>  (1)..(3)
<223>  LNA_modification

<220>
<221>  misc_feature
<222>  (1)..(15)
<223>  phosphorothioate_linkages

<220>
<221>  misc_feature
<222>  (13)..(15)
<223>  LNA_modification

<400>  62
cctatgccat ttacg                                                        15


<210>  63
<211>  16
<212>  DNA
<213>  Homo sapiens

<400>  63
agaagcgcgg ctggtg                                                       16


<210>  64
<211>  16
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antisense_sequence_5-3_partially_with_phosphorothioate_linkages
       _ [*]_and_LNA_modifications_[+] (see Misc_Features)


<220>
<221>  misc_feature
<222>  (1)..(3)
<223>  LNA_modification

<220>
<221>  misc_feature
<222>  (1)..(16)
<223>  phosphorothioate_linkages

<220>
<221>  misc_feature
<222>  (14)..(16)
<223>  LNA_modification

<400>  64
agaagcgcgg ctggtg                                                       16


<210>  65
<211>  16
<212>  DNA
<213>  Homo sapiens

<400>  65
tcaggacttg atggtc                                                       16


<210>  66
<211>  16
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antisense_sequence_5-3_partially_with_phosphorothioate_linkages
       _ [*]_and_LNA_modifications_[+] (see Misc_Features)


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  LNA_modification

<220>
<221>  misc_feature
<222>  (1)..(16)
<223>  phosphorothioate_linkages

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  LNA_modification

<220>
<221>  misc_feature
<222>  (14)..(16)
<223>  LNA_modification

<400>  66
tcaggacttg atggtc                                                       16


<210>  67
<211>  16
<212>  DNA
<213>  Homo sapiens

<400>  67
ctctcttgga attggt                                                       16


<210>  68
<211>  16
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antisense_sequence_5-3_partially_with_phosphorothioate_linkages
       _ [*]_and_LNA_modifications_[+] (see Misc_Features)


<220>
<221>  misc_feature
<222>  (1)..(3)
<223>  LNA_modification

<220>
<221>  misc_feature
<222>  (1)..(16)
<223>  phosphorothioate_linkages

<220>
<221>  misc_feature
<222>  (14)..(16)
<223>  LNA_modification

<400>  68
ctctcttgga attggt                                                       16


<210>  69
<211>  16
<212>  DNA
<213>  Homo sapiens

<400>  69
gaccaattca gctgta                                                       16


<210>  70
<211>  16
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antisense_sequence_5-3_partially_with_phosphorothioate_linkages
       _ [*]_and_LNA_modifications_[+] (see Misc_Features)


<220>
<221>  misc_feature
<222>  (1)..(3)
<223>  LNA_modification

<220>
<221>  misc_feature
<222>  (1)..(16)
<223>  phosphorothioate_linkages

<220>
<221>  misc_feature
<222>  (14)..(16)
<223>  LNA_modification

<400>  70
gaccaattca gctgta                                                       16


<210>  71
<211>  16
<212>  DNA
<213>  Homo sapiens

<400>  71
ttaccaagtg agtcct                                                       16


<210>  72
<211>  16
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antisense_sequence_5-3_partially_with_phosphorothioate_linkages
       _ [*]_and_LNA_modifications_[+] (see Misc_Features)


<220>
<221>  misc_feature
<222>  (1)..(3)
<223>  LNA_modification

<220>
<221>  misc_feature
<222>  (1)..(16)
<223>  phosphorothioate_linkages

<220>
<221>  misc_feature
<222>  (14)..(16)
<223>  LNA_modification

<400>  72
ttaccaagtg agtcct                                                       16


<210>  73
<211>  16
<212>  DNA
<213>  Homo sapiens

<400>  73
tgtcagtgct acacca                                                       16


<210>  74
<211>  16
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antisense_sequence_5-3_partially_with_phosphorothioate_linkages
       _ [*]_and_LNA_modifications_[+] (see Misc_Features)


<220>
<221>  misc_feature
<222>  (1)..(3)
<223>  LNA_modification

<220>
<221>  misc_feature
<222>  (1)..(16)
<223>  phosphorothioate_linkages

<220>
<221>  misc_feature
<222>  (14)..(16)
<223>  LNA_modification

<400>  74
tgtcagtgct acacca                                                       16


<210>  75
<211>  16
<212>  DNA
<213>  Homo sapiens

<400>  75
aatgctggat tacgtc                                                       16


<210>  76
<211>  16
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antisense_sequence_5-3_partially_with_phosphorothioate_linkages
       _ [*]_and_LNA_modifications_[+] (see Misc_Features)


<220>
<221>  misc_feature
<222>  (1)..(3)
<223>  LNA_modification

<220>
<221>  misc_feature
<222>  (1)..(16)
<223>  phosphorothioate_linkages

<220>
<221>  misc_feature
<222>  (14)..(16)
<223>  LNA_modification

<400>  76
aatgctggat tacgtc                                                       16


<210>  77
<211>  16
<212>  DNA
<213>  Homo sapiens

<400>  77
ttcgccaggt tccatt                                                       16


<210>  78
<211>  16
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antisense_sequence_5-3_partially_with_phosphorothioate_linkages
       _ [*]_and_LNA_modifications_[+] (see Misc_Features)


<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  LNA_modification

<220>
<221>  misc_feature
<222>  (1)..(16)
<223>  phosphorothioate_linkages

<220>
<221>  misc_feature
<222>  (14)..(16)
<223>  LNA_modification

<400>  78
ttcgccaggt tccatt                                                       16


<210>  79
<211>  16
<212>  DNA
<213>  Homo sapiens

<400>  79
gctttcgcca ggttcc                                                       16


<210>  80
<211>  16
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antisense_sequence_5-3_partially_with_phosphorothioate_linkages
       _ [*]_and_LNA_modifications_[+] (see Misc_Features)


<220>
<221>  misc_feature
<222>  (1)..(3)
<223>  LNA_modification

<220>
<221>  misc_feature
<222>  (1)..(16)
<223>  phosphorothioate_linkages

<220>
<221>  misc_feature
<222>  (14)..(16)
<223>  LNA_modification

<400>  80
gctttcgcca ggttcc                                                       16


<210>  81
<211>  16
<212>  DNA
<213>  Homo sapiens

<400>  81
agtatcaagg tctccc                                                       16


<210>  82
<211>  16
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antisense_sequence_5-3_partially_with_phosphorothioate_linkages
       _ [*]_and_LNA_modifications_[+] (see Misc_Features)


<220>
<221>  misc_feature
<222>  (1)..(3)
<223>  LNA_modification

<220>
<221>  misc_feature
<222>  (1)..(16)
<223>  phosphorothioate_linkages

<220>
<221>  misc_feature
<222>  (14)..(16)
<223>  LNA_modification

<400>  82
agtatcaagg tctccc                                                       16


<210>  83
<211>  16
<212>  DNA
<213>  Homo sapiens

<400>  83
agttatagag gagacc                                                       16


<210>  84
<211>  16
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antisense_sequence_5-3_partially_with_phosphorothioate_linkages
       _ [*]_and_LNA_modifications_[+] (see Misc_Features)


<220>
<221>  misc_feature
<222>  (1)..(3)
<223>  LNA_modification

<220>
<221>  misc_feature
<222>  (1)..(16)
<223>  phosphorothioate_linkages

<220>
<221>  misc_feature
<222>  (14)..(16)
<223>  LNA_modification

<400>  84
agttatagag gagacc                                                       16


<210>  85
<211>  16
<212>  DNA
<213>  Homo sapiens

<400>  85
gtggttacag cgatga                                                       16


<210>  86
<211>  16
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antisense_sequence_5-3_partially_with_phosphorothioate_linkages
       _ [*]_and_LNA_modifications_[+] (see Misc_Features)


<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  LNA_modification

<220>
<221>  misc_feature
<222>  (1)..(16)
<223>  phosphorothioate_linkages

<220>
<221>  misc_feature
<222>  (14)..(16)
<223>  LNA_modification

<400>  86
gtggttacag cgatga                                                       16


<210>  87
<211>  16
<212>  DNA
<213>  Homo sapiens

<400>  87
gattgactca gtgcac                                                       16


<210>  88
<211>  16
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antisense_sequence_5-3_partially_with_phosphorothioate_linkages
       _ [*]_and_LNA_modifications_[+] (see Misc_Features)


<220>
<221>  misc_feature
<222>  (1)..(3)
<223>  LNA_modification

<220>
<221>  misc_feature
<222>  (1)..(16)
<223>  phosphorothioate_linkages

<220>
<221>  misc_feature
<222>  (15)..(16)
<223>  LNA_modification

<400>  88
gattgactca gtgcac                                                       16


<210>  89
<211>  16
<212>  DNA
<213>  Homo sapiens

<400>  89
tagcagtcaa ggtaca                                                       16


<210>  90
<211>  16
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antisense_sequence_5-3_partially_with_phosphorothioate_linkages
       _ [*]_and_LNA_modifications_[+] (see Misc_Features)


<220>
<221>  misc_feature
<222>  (1)..(3)
<223>  LNA_modification

<220>
<221>  misc_feature
<222>  (1)..(16)
<223>  phosphorothioate_linkages

<220>
<221>  misc_feature
<222>  (14)..(16)
<223>  LNA_modification

<400>  90
tagcagtcaa ggtaca                                                       16


<210>  91
<211>  16
<212>  DNA
<213>  Homo sapiens

<400>  91
gttcaagcac aacgaa                                                       16


<210>  92
<211>  16
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antisense_sequence_5-3_partially_with_phosphorothioate_linkages
       _ [*]_and_LNA_modifications_[+] (see Misc_Features)


<220>
<221>  misc_feature
<222>  (1)..(3)
<223>  LNA_modification

<220>
<221>  misc_feature
<222>  (1)..(16)
<223>  phosphorothioate_linkages

<220>
<221>  misc_feature
<222>  (14)..(16)
<223>  LNA_modification

<400>  92
gttcaagcac aacgaa                                                       16


<210>  93
<211>  16
<212>  DNA
<213>  Homo sapiens

<400>  93
gcctatgcca tttacg                                                       16


<210>  94
<211>  16
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antisense_sequence_5-3_partially_with_phosphorothioate_linkages
       _ [*]_and_LNA_modifications_[+] (see Misc_Features)


<220>
<221>  misc_feature
<222>  (1)..(3)
<223>  LNA_modification

<220>
<221>  misc_feature
<222>  (1)..(16)
<223>  phosphorothioate_linkages

<220>
<221>  misc_feature
<222>  (14)..(16)
<223>  LNA_modification

<400>  94
gcctatgcca tttacg                                                       16


<210>  95
<211>  17
<212>  DNA
<213>  Homo sapiens

<400>  95
agaagcgcgg ctggtgc                                                      17


<210>  96
<211>  17
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antisense_sequence_5-3_partially_with_phosphorothioate_linkages
       _ [*]_and_LNA_modifications_[+] (see Misc_Features)


<220>
<221>  misc_feature
<222>  (1)..(3)
<223>  LNA_modification

<220>
<221>  misc_feature
<222>  (1)..(17)
<223>  phosphorothioate_linkages

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  LNA_modification

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  LNA_modification

<400>  96
agaagcgcgg ctggtgc                                                      17


<210>  97
<211>  17
<212>  DNA
<213>  Homo sapiens

<400>  97
accaattcag ctgtatg                                                      17


<210>  98
<211>  17
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antisense_sequence_5-3_partially_with_phosphorothioate_linkages
       _ [*]_and_LNA_modifications_[+] (see Misc_Features)


<220>
<221>  misc_feature
<222>  (1)..(3)
<223>  LNA_modification

<220>
<221>  misc_feature
<222>  (1)..(17)
<223>  phosphorothioate_linkages

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  LNA_modification

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  LNA_modification

<400>  98
accaattcag ctgtatg                                                      17


<210>  99
<211>  17
<212>  DNA
<213>  Homo sapiens

<400>  99
tgctggatta cgtctcc                                                      17


<210>  100
<211>  17
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antisense_sequence_5-3_partially_with_phosphorothioate_linkages
       _ [*]_and_LNA_modifications_[+] (see Misc_Features)


<220>
<221>  misc_feature
<222>  (1)..(3)
<223>  LNA_modification

<220>
<221>  misc_feature
<222>  (1)..(17)
<223>  phosphorothioate_linkages

<220>
<221>  misc_feature
<222>  (15)..(17)
<223>  LNA_modification

<400>  100
tgctggatta cgtctcc                                                      17


<210>  101
<211>  17
<212>  DNA
<213>  Homo sapiens

<400>  101
tttcgccagg ttccatt                                                      17


<210>  102
<211>  17
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antisense_sequence_5-3_partially_with_phosphorothioate_linkages
       _ [*]_and_LNA_modifications_[+] (see Misc_Features)


<220>
<221>  misc_feature
<222>  (1)..(3)
<223>  LNA_modification

<220>
<221>  misc_feature
<222>  (1)..(17)
<223>  phosphorothioate_linkages

<220>
<221>  misc_feature
<222>  (15)..(17)
<223>  LNA_modification

<400>  102
tttcgccagg ttccatt                                                      17


<210>  103
<211>  17
<212>  DNA
<213>  Homo sapiens

<400>  103
gtatcaaggt ctccctc                                                      17


<210>  104
<211>  17
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antisense_sequence_5-3_partially_with_phosphorothioate_linkages
       _ [*]_and_LNA_modifications_[+] (see Misc_Features)


<220>
<221>  misc_feature
<222>  (1)..(3)
<223>  LNA_modification

<220>
<221>  misc_feature
<222>  (1)..(17)
<223>  phosphorothioate_linkages

<220>
<221>  misc_feature
<222>  (15)..(17)
<223>  LNA_modification

<400>  104
gtatcaaggt ctccctc                                                      17


<210>  105
<211>  17
<212>  DNA
<213>  Homo sapiens

<400>  105
ggtggttaca gcgatga                                                      17


<210>  106
<211>  17
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antisense_sequence_5-3_partially_with_phosphorothioate_linkages
       _ [*]_and_LNA_modifications_[+] (see Misc_Features)


<220>
<221>  misc_feature
<222>  (1)..(3)
<223>  LNA_modification

<220>
<221>  misc_feature
<222>  (1)..(17)
<223>  phosphorothioate_linkages

<220>
<221>  misc_feature
<222>  (15)..(17)
<223>  LNA_modification

<400>  106
ggtggttaca gcgatga                                                      17


<210>  107
<211>  17
<212>  DNA
<213>  Homo sapiens

<400>  107
ggactagatt gactcag                                                      17


<210>  108
<211>  17
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antisense_sequence_5-3_partially_with_phosphorothioate_linkages
       _ [*]_and_LNA_modifications_[+] (see Misc_Features)


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  LNA_modification

<220>
<221>  misc_feature
<222>  (1)..(17)
<223>  phosphorothioate_linkages

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  LNA_modification

<220>
<221>  misc_feature
<222>  (15)..(17)
<223>  LNA_modification

<400>  108
ggactagatt gactcag                                                      17


<210>  109
<211>  17
<212>  DNA
<213>  Homo sapiens

<400>  109
acaacgaatg aggcttt                                                      17


<210>  110
<211>  17
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antisense_sequence_5-3_partially_with_phosphorothioate_linkages
       _ [*]_and_LNA_modifications_[+] (see Misc_Features)


<220>
<221>  misc_feature
<222>  (1)..(3)
<223>  LNA_modification

<220>
<221>  misc_feature
<222>  (1)..(17)
<223>  phosphorothioate_linkages

<220>
<221>  misc_feature
<222>  (15)..(17)
<223>  LNA_modification

<400>  110
acaacgaatg aggcttt                                                      17


<210>  111
<211>  17
<212>  DNA
<213>  Homo sapiens

<400>  111
gactgagtag actatgt                                                      17


<210>  112
<211>  17
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antisense_sequence_5-3_partially_with_phosphorothioate_linkages
       _ [*]_and_LNA_modifications_[+] (see Misc_Features)


<220>
<221>  misc_feature
<222>  (1)..(3)
<223>  LNA_modification

<220>
<221>  misc_feature
<222>  (1)..(17)
<223>  phosphorothioate_linkages

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  LNA_modification

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  LNA_modification

<400>  112
gactgagtag actatgt                                                      17


<210>  113
<211>  17
<212>  DNA
<213>  Homo sapiens

<400>  113
gccatttacg atgaaac                                                      17


<210>  114
<211>  17
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antisense_sequence_5-3_partially_with_phosphorothioate_linkages
       _ [*]_and_LNA_modifications_[+] (see Misc_Features)


<220>
<221>  misc_feature
<222>  (1)..(3)
<223>  LNA_modification

<220>
<221>  misc_feature
<222>  (1)..(17)
<223>  phosphorothioate_linkages

<220>
<221>  misc_feature
<222>  (15)..(17)
<223>  LNA_modification

<400>  114
gccatttacg atgaaac                                                      17


<210>  115
<211>  3691
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antisense_sequence_5-3_partially_with_phosphorothioate_linkages
       _ [*]_and_LNA_modifications_[+] (see Misc_Features)

<400>  115
ggcgcaacgc tgagcagctg gcgcgtcccg cgcggcccca gttctgcgca gcttcccgag       60

gctccgcacc agccgcgctt ctgtccgcct gcagggcatt ccagaaagat gaggatattt      120

gctgtcttta tattcatgac ctactggcat ttgctgaacg catttactgt cacggttccc      180

aaggacctat atgtggtaga gtatggtagc aatatgacaa ttgaatgcaa attcccagta      240

gaaaaacaat tagacctggc tgcactaatt gtctattggg aaatggagga taagaacatt      300

attcaatttg tgcatggaga ggaagacctg aaggttcagc atagtagcta cagacagagg      360

gcccggctgt tgaaggacca gctctccctg ggaaatgctg cacttcagat cacagatgtg      420

aaattgcagg atgcaggggt gtaccgctgc atgatcagct atggtggtgc cgactacaag      480

cgaattactg tgaaagtcaa tgccccatac aacaaaatca accaaagaat tttggttgtg      540

gatccagtca cctctgaaca tgaactgaca tgtcaggctg agggctaccc caaggccgaa      600

gtcatctgga caagcagtga ccatcaagtc ctgagtggta agaccaccac caccaattcc      660

aagagagagg agaagctttt caatgtgacc agcacactga gaatcaacac aacaactaat      720

gagattttct actgcacttt taggagatta gatcctgagg aaaaccatac agctgaattg      780

gtcatcccag aactacctct ggcacatcct ccaaatgaaa ggactcactt ggtaattctg      840

ggagccatct tattatgcct tggtgtagca ctgacattca tcttccgttt aagaaaaggg      900

agaatgatgg atgtgaaaaa atgtggcatc caagatacaa actcaaagaa gcaaagtgat      960

acacatttgg aggagacgta atccagcatt ggaacttctg atcttcaagc agggattctc     1020

aacctgtggt ttaggggttc atcggggctg agcgtgacaa gaggaaggaa tgggcccgtg     1080

ggatgcaggc aatgtgggac ttaaaaggcc caagcactga aaatggaacc tggcgaaagc     1140

agaggaggag aatgaagaaa gatggagtca aacagggagc ctggagggag accttgatac     1200

tttcaaatgc ctgaggggct catcgacgcc tgtgacaggg agaaaggata cttctgaaca     1260

aggagcctcc aagcaaatca tccattgctc atcctaggaa gacgggttga gaatccctaa     1320

tttgagggtc agttcctgca gaagtgccct ttgcctccac tcaatgcctc aatttgtttt     1380

ctgcatgact gagagtctca gtgttggaac gggacagtat ttatgtatga gtttttccta     1440

tttattttga gtctgtgagg tcttcttgtc atgtgagtgt ggttgtgaat gatttctttt     1500

gaagatatat tgtagtagat gttacaattt tgtcgccaaa ctaaacttgc tgcttaatga     1560

tttgctcaca tctagtaaaa catggagtat ttgtaaggtg cttggtctcc tctataacta     1620

caagtataca ttggaagcat aaagatcaaa ccgttggttg cataggatgt cacctttatt     1680

taacccatta atactctggt tgacctaatc ttattctcag acctcaagtg tctgtgcagt     1740

atctgttcca tttaaatatc agctttacaa ttatgtggta gcctacacac ataatctcat     1800

ttcatcgctg taaccaccct gttgtgataa ccactattat tttacccatc gtacagctga     1860

ggaagcaaac agattaagta acttgcccaa accagtaaat agcagacctc agactgccac     1920

ccactgtcct tttataatac aatttacagc tatattttac tttaagcaat tcttttattc     1980

aaaaaccatt tattaagtgc ccttgcaata tcaatcgctg tgccaggcat tgaatctaca     2040

gatgtgagca agacaaagta cctgtcctca aggagctcat agtataatga ggagattaac     2100

aagaaaatgt attattacaa tttagtccag tgtcatagca taaggatgat gcgaggggaa     2160

aacccgagca gtgttgccaa gaggaggaaa taggccaatg tggtctggga cggttggata     2220

tacttaaaca tcttaataat cagagtaatt ttcatttaca aagagaggtc ggtacttaaa     2280

ataaccctga aaaataacac tggaattcct tttctagcat tatatttatt cctgatttgc     2340

ctttgccata taatctaatg cttgtttata tagtgtctgg tattgtttaa cagttctgtc     2400

ttttctattt aaatgccact aaattttaaa ttcatacctt tccatgattc aaaattcaaa     2460

agatcccatg ggagatggtt ggaaaatctc cacttcatcc tccaagccat tcaagtttcc     2520

tttccagaag caactgctac tgcctttcat tcatatgttc ttctaaagat agtctacatt     2580

tggaaatgta tgttaaaagc acgtattttt aaaatttttt tcctaaatag taacacattg     2640

tatgtctgct gtgtactttg ctatttttat ttattttagt gtttcttata tagcagatgg     2700

aatgaatttg aagttcccag ggctgaggat ccatgccttc tttgtttcta agttatcttt     2760

cccatagctt ttcattatct ttcatatgat ccagtatatg ttaaatatgt cctacatata     2820

catttagaca accaccattt gttaagtatt tgctctagga cagagtttgg atttgtttat     2880

gtttgctcaa aaggagaccc atgggctctc cagggtgcac tgagtcaatc tagtcctaaa     2940

aagcaatctt attattaact ctgtatgaca gaatcatgtc tggaactttt gttttctgct     3000

ttctgtcaag tataaacttc actttgatgc tgtacttgca aaatcacatt ttctttctgg     3060

aaattccggc agtgtacctt gactgctagc taccctgtgc cagaaaagcc tcattcgttg     3120

tgcttgaacc cttgaatgcc accagctgtc atcactacac agccctccta agaggcttcc     3180

tggaggtttc gagattcaga tgccctggga gatcccagag tttcctttcc ctcttggcca     3240

tattctggtg tcaatgacaa ggagtacctt ggctttgcca catgtcaagg ctgaagaaac     3300

agtgtctcca acagagctcc ttgtgttatc tgtttgtaca tgtgcatttg tacagtaatt     3360

ggtgtgacag tgttctttgt gtgaattaca ggcaagaatt gtggctgagc aaggcacata     3420

gtctactcag tctattccta agtcctaact cctccttgtg gtgttggatt tgtaaggcac     3480

tttatccctt ttgtctcatg tttcatcgta aatggcatag gcagagatga tacctaattc     3540

tgcatttgat tgtcactttt tgtacctgca ttaatttaat aaaatattct tatttatttt     3600

gttacttggt acaccagcat gtccattttc ttgtttattt tgtgtttaat aaaatgttca     3660

gtttaacatc ccagtggaga aagttaaaaa a                                    3691


<210>  116
<211>  3653
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antisense_sequence_5-3_partially_with_phosphorothioate_linkages
       _ [*]_and_LNA_modifications_[+] (see Misc_Features)

<400>  116
gaaatcgtgg tccccaagcc tcatgccagg ctgcacttgc acgtcgcggg ccagtctcct       60

cgcctgcaga tagttcccaa aacatgagga tatttgctgg cattatattc acagcctgct      120

gtcacttgct acgggcgttt actatcacgg ctccaaagga cttgtacgtg gtggagtatg      180

gcagcaacgt cacgatggag tgcagattcc ctgtagaacg ggagctggac ctgcttgcgt      240

tagtggtgta ctgggaaaag gaagatgagc aagtgattca gtttgtggca ggagaggagg      300

accttaagcc tcagcacagc aacttcaggg ggagagcctc gctgccaaag gaccagcttt      360

tgaagggaaa tgctgccctt cagatcacag acgtcaagct gcaggacgca ggcgtttact      420

gctgcataat cagctacggt ggtgcggact acaagcgaat cacgctgaaa gtcaatgccc      480

cataccgcaa aatcaaccag agaatttccg tggatccagc cacttctgag catgaactaa      540

tatgtcaggc cgagggttat ccagaagctg aggtaatctg gacaaacagt gaccaccaac      600

ccgtgagtgg gaagagaagt gtcaccactt cccggacaga ggggatgctt ctcaatgtga      660

ccagcagtct gagggtcaac gccacagcga atgatgtttt ctactgtacg ttttggagat      720

cacagccagg gcaaaaccac acagcggagc tgatcatccc agaactgcct gcaacacatc      780

ctccacagaa caggactcac tgggtgcttc tgggatccat cctgttgttc ctcattgtag      840

tgtccacggt cctcctcttc ttgagaaaac aagtgagaat gctagatgtg gagaaatgtg      900

gcgttgaaga tacaagctca aaaaaccgaa atgatacaca attcgaggag acgtaagcag      960

tgttgaaccc tctgatcgtc gattggcagc ttgtggtctg tgaaagaaag ggcccatggg     1020

acatgagtcc aaagactcaa gatggaacct gagggagaga accaagaaag tgttgggaga     1080

ggagcctgga acaacggaca ttttttccag ggagacactg ctaagcaagt tgcccatcag     1140

tcgtcttggg aaatggattg agggttcctg gcttagcagc tggtccttgc acagtgacct     1200

tttcctctgc tcagtgccgg gatgagagat ggagtcatga gtgttgaaga ataagtgcct     1260

tctatttatt ttgagtctgt gtgttctcac tttgggcatg taattatgac tggtgaattc     1320

tgacgacatg atagatctta agatgtagtc accaaactca actgctgctt agcatcctcc     1380

gtaactactg atacaagcag ggaacacaga ggtcacctgc ttggtttgac aggctcttgc     1440

tgtctgactc aaataatctt tatttttcag tcctcaaggc tcttcgatag cagttgttct     1500

gtatcagcct tataggtgtc aggtatagca ctcaacatct catctcatta caatagcaac     1560

cctcatcacc atagcaacag ctaacctctg ttatcctcac ttcatagcca ggaagctgag     1620

cgactaagtc acttgcccac agagtatcag ctctcagatt tctgttcttc agccactgtc     1680

ctttcaggat agaatttgtc gttaagaaat taatttaaaa actgattatt gagtagcatt     1740

gtatatcaat cacaacatgc cttgtgcact gtgctggcct ctgagcataa agatgtacgc     1800

cggagtaccg gtcggacatg tttatgtgtg ttaaatactc agagaaatgt tcattaacaa     1860

ggagcttgca ttttagagac actggaaagt aactccagtt cattgtctag cattacattt     1920

acctcatttg ctatccttgc catacagtct cttgttctcc atgaagtgtc atgaatcttg     1980

ttgaatagtt cttttatttt ttaaatgttt ctatttaaat gatattgaca tctgaggcga     2040

tagctcagtt ggtaaaaccc tttcctcaca agtgtgaaac cctgagtctt atccctagaa     2100

cccacataaa aaacagttgc gtatgtttgt gcatgctttt gatcccagca ctagggaggc     2160

agaggcaggc agatcctgag ctctcattga ccacccagcc tagcctacat ggttagctcc     2220

aggcctacag gagctggcag agcctgaaaa acgatgccta gacacacaca cacacacaca     2280

cacacacaca cacacacaca cacaccatgt actcatagac ctaagtgcac cctcctacac     2340

atgcacacac atacaattca aacacaaatc aacagggaat tgtctcagaa tggtccccaa     2400

gacaaagaag aagaaaaaca ccaaaccagc tctattccct cagcctatcc tctctactcc     2460

ttcctagaag caactactat tgtttttgta tataaattta cccaacgaca gttaatatgt     2520

agaatatata ttaaagtgtc tgtcaatata tattatctct ttctttcttt cttcctttct     2580

ttctttcttt ctttctttct ttctttcttt ctttctttct ttcttccttc cttccttcct     2640

tccttccttc cttccttcct ttctttcttt ctttcttttt ttctgtctat ctgtacctaa     2700

atggttgctc actatgcatt ttctgtgctc ttcgcccttt ttatttaatg tatggatatt     2760

tatgctgctt ccagaatgga tctaaagctc tttgtttcta ggttttctcc cccatccttc     2820

taggcatctc tcacactgtc taggccagac accatgtctg ctgcctgaat ctgtagacac     2880

catttataaa gcacgtactc accgagtttg tatttggctt gttctgtgtc tgattaaagg     2940

gagaccatga gtccccaggg tacactgagt taccccagta ccaaggggga gccttgtttg     3000

tgtctccatg gcagaagcag gcctggagcc attttggttt cttccttgac ttctctcaaa     3060

cacagacgcc tcacttgctc attacaggtt ctcctttggg aatgtcagca ttgctccttg     3120

actgctggct gccctggaag gagcccatta gctctgtgtg agcccttgac agctactgcc     3180

tctccttacc acaggggcct ctaagatact gttacctaga ggtcttgagg atctgtgttc     3240

tctgggggga ggaaaggagg aggaacccag aactttctta cagttttcct tgttctgtca     3300

catgtcaaga ctgaaggaac aggctgggct acgtagtgag atcctgtctc aaaggaaaga     3360

cgagcatagc cgaacccccg gtggaacccc ctctgttacc tgttcacaca agcttattga     3420

tgagtctcat gttaatgtct tgtttgtatg aagtttaaga aaatatcggg ttgggcaaca     3480

cattctattt attcatttta tttgaaatct taatgccatc tcatggtgtt ggattggtgt     3540

ggcactttat tcttttgtgt tgtgtataac cataaatttt attttgcatc agattgtcaa     3600

tgtattgcat taatttaata aatattttta tttattaaaa aaaaaaaaaa aaa            3653


<210>  117
<211>  17
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antisense_sequence_5-3_partially_with_phosphorothioate_linkages
       _ [*]_and_LNA_modifications_[+] (see Misc_Features)


<220>
<221>  misc_feature
<222>  (1)..(3)
<223>  LNA_modification

<220>
<221>  misc_feature
<222>  (1)..(15)
<223>  phosphorothioate_linkages

<220>
<221>  misc_feature
<222>  (13)..(15)
<223>  LNA_modification

<400>  117
atactccacc acgtaca                                                      17


<210>  118
<211>  17
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antisense_sequence_5-3_partially_with_phosphorothioate_linkages
       _ [*]_and_LNA_modifications_[+] (see Misc_Features)


<220>
<221>  misc_feature
<222>  (1)..(3)
<223>  LNA_modification

<220>
<221>  misc_feature
<222>  (1)..(15)
<223>  phosphorothioate_linkages

<220>
<221>  misc_feature
<222>  (13)..(15)
<223>  LNA_modification

<400>  118
gccatactcc accacgt                                                      17


<210>  119
<211>  17
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antisense_sequence_5-3_partially_with_phosphorothioate_linkages
       _ [*]_and_LNA_modifications_[+] (see Misc_Features)


<220>
<221>  misc_feature
<222>  (1)..(3)
<223>  LNA_modification

<220>
<221>  misc_feature
<222>  (1)..(15)
<223>  phosphorothioate_linkages

<220>
<221>  misc_feature
<222>  (13)..(15)
<223>  LNA_modification

<400>  119
gattcgcttg tagtccg                                                      17


<210>  120
<211>  17
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antisense_sequence_5-3_partially_with_phosphorothioate_linkages
       _ [*]_and_LNA_modifications_[+] (see Misc_Features)


<220>
<221>  misc_feature
<222>  (1)..(3)
<223>  LNA_modification

<220>
<221>  misc_feature
<222>  (1)..(15)
<223>  phosphorothioate_linkages

<220>
<221>  misc_feature
<222>  (13)..(15)
<223>  LNA_modification

<400>  120
gcttacgtct cctcgaa                                                      17


<210>  121
<211>  17
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antisense_sequence_5-3_partially_with_phosphorothioate_linkages
       _ [*]_and_LNA_modifications_[+] (see Misc_Features)


<220>
<221>  misc_feature
<222>  (1)..(3)
<223>  LNA_modification

<220>
<221>  misc_feature
<222>  (1)..(15)
<223>  phosphorothioate_linkages

<220>
<221>  misc_feature
<222>  (13)..(15)
<223>  LNA_modification

<400>  121
caacactgct tacgtct                                                      17


<210>  122
<211>  17
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antisense_sequence_5-3_partially_with_phosphorothioate_linkages
       _ [*]_and_LNA_modifications_[+] (see Misc_Features)


<220>
<221>  misc_feature
<222>  (1)..(3)
<223>  LNA_modification

<220>
<221>  misc_feature
<222>  (1)..(16)
<223>  phosphorothioate_linkages

<220>
<221>  misc_feature
<222>  (14)..(16)
<223>  LNA_modification

<400>  122
gttcaacact gcttacg                                                      17


<210>  123
<211>  17
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antisense_sequence_5-3_partially_with_phosphorothioate_linkages
       _ [*]_and_LNA_modifications_[+] (see Misc_Features)


<220>
<221>  misc_feature
<222>  (1)..(3)
<223>  LNA_modification

<220>
<221>  misc_feature
<222>  (1)..(16)
<223>  phosphorothioate_linkages

<220>
<221>  misc_feature
<222>  (14)..(16)
<223>  LNA_modification

<400>  123
ggttcaacac tgcttac                                                      17


<210>  124
<211>  17
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antisense_sequence_5-3_partially_with_phosphorothioate_linkages
       _ [*]_and_LNA_modifications_[+] (see Misc_Features)


<220>
<221>  misc_feature
<222>  (1)..(3)
<223>  LNA_modification

<220>
<221>  misc_feature
<222>  (1)..(16)
<223>  phosphorothioate_linkages

<220>
<221>  misc_feature
<222>  (14)..(16)
<223>  LNA_modification

<400>  124
acaaactcgg tgagtac                                                      17


<210>  125
<211>  16
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antisense_sequence_5-3_partially_with_phosphorothioate_linkages
       _ [*]_and_LNA_modifications_[+] (see Misc_Features)


<220>
<221>  misc_feature
<222>  (1)..(3)
<223>  LNA_modification

<220>
<221>  misc_feature
<222>  (1)..(16)
<223>  phosphorothioate_linkages

<220>
<221>  misc_feature
<222>  (14)..(16)
<223>  LNA_modification

<400>  125
tactccacca cgtaca                                                       16


<210>  126
<211>  16
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antisense_sequence_5-3_partially_with_phosphorothioate_linkages
       _ [*]_and_LNA_modifications_[+] (see Misc_Features)


<220>
<221>  misc_feature
<222>  (1)..(3)
<223>  LNA_modification

<220>
<221>  misc_feature
<222>  (1)..(16)
<223>  phosphorothioate_linkages

<220>
<221>  misc_feature
<222>  (14)..(16)
<223>  LNA_modification

<400>  126
atactccacc acgtac                                                       16


<210>  127
<211>  16
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antisense_sequence_5-3_partially_with_phosphorothioate_linkages
       _ [*]_and_LNA_modifications_[+] (see Misc_Features)


<220>
<221>  misc_feature
<222>  (1)..(3)
<223>  LNA_modification

<220>
<221>  misc_feature
<222>  (1)..(16)
<223>  phosphorothioate_linkages

<220>
<221>  misc_feature
<222>  (14)..(16)
<223>  LNA_modification

<400>  127
catactccac cacgta                                                       16


<210>  128
<211>  16
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antisense_sequence_5-3_partially_with_phosphorothioate_linkages
       _ [*]_and_LNA_modifications_[+] (see Misc_Features)


<220>
<221>  misc_feature
<222>  (1)..(3)
<223>  LNA_modification

<220>
<221>  misc_feature
<222>  (1)..(16)
<223>  phosphorothioate_linkages

<220>
<221>  misc_feature
<222>  (14)..(16)
<223>  LNA_modification

<400>  128
ccatactcca ccacgt                                                       16


<210>  129
<211>  16
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antisense_sequence_5-3_partially_with_phosphorothioate_linkages
       _ [*]_and_LNA_modifications_[+] (see Misc_Features)


<220>
<221>  misc_feature
<222>  (1)..(3)
<223>  LNA_modification

<220>
<221>  misc_feature
<222>  (1)..(16)
<223>  phosphorothioate_linkages

<220>
<221>  misc_feature
<222>  (14)..(16)
<223>  LNA_modification

<400>  129
gccatactcc accacg                                                       16


<210>  130
<211>  16
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antisense_sequence_5-3_partially_with_phosphorothioate_linkages
       _ [*]_and_LNA_modifications_[+] (see Misc_Features)


<220>
<221>  misc_feature
<222>  (1)..(3)
<223>  LNA_modification

<220>
<221>  misc_feature
<222>  (1)..(16)
<223>  phosphorothioate_linkages

<220>
<221>  misc_feature
<222>  (14)..(16)
<223>  LNA_modification

<400>  130
ttcgcttgta gtccgc                                                       16


<210>  131
<211>  16
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antisense_sequence_5-3_partially_with_phosphorothioate_linkages
       _ [*]_and_LNA_modifications_[+] (see Misc_Features)


<220>
<221>  misc_feature
<222>  (1)..(3)
<223>  LNA_modification

<220>
<221>  misc_feature
<222>  (1)..(16)
<223>  phosphorothioate_linkages

<220>
<221>  misc_feature
<222>  (14)..(16)
<223>  LNA_modification

<400>  131
attcgcttgt agtccg                                                       16


<210>  132
<211>  16
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antisense_sequence_5-3_partially_with_phosphorothioate_linkages
       _ [*]_and_LNA_modifications_[+] (see Misc_Features)


<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  LNA_modification

<220>
<221>  misc_feature
<222>  (1)..(16)
<223>  phosphorothioate_linkages

<220>
<221>  misc_feature
<222>  (15)..(16)
<223>  LNA_modification

<400>  132
gattcgcttg tagtcc                                                       16


<210>  133
<211>  16
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antisense_sequence_5-3_partially_with_phosphorothioate_linkages
       _ [*]_and_LNA_modifications_[+] (see Misc_Features)


<220>
<221>  misc_feature
<222>  (1)..(3)
<223>  LNA_modification

<220>
<221>  misc_feature
<222>  (1)..(16)
<223>  phosphorothioate_linkages

<220>
<221>  misc_feature
<222>  (14)..(16)
<223>  LNA_modification

<400>  133
tgattcgctt gtagtc                                                       16


<210>  134
<211>  16
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antisense_sequence_5-3_partially_with_phosphorothioate_linkages
       _ [*]_and_LNA_modifications_[+] (see Misc_Features)


<220>
<221>  misc_feature
<222>  (1)..(3)
<223>  LNA_modification

<220>
<221>  misc_feature
<222>  (1)..(16)
<223>  phosphorothioate_linkages

<220>
<221>  misc_feature
<222>  (14)..(16)
<223>  LNA_modification

<400>  134
gttgattttg cggtat                                                       16


<210>  135
<211>  16
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antisense_sequence_5-3_partially_with_phosphorothioate_linkages
       _ [*]_and_LNA_modifications_[+] (see Misc_Features)


<220>
<221>  misc_feature
<222>  (1)..(3)
<223>  LNA_modification

<220>
<221>  misc_feature
<222>  (1)..(16)
<223>  phosphorothioate_linkages

<220>
<221>  misc_feature
<222>  (14)..(16)
<223>  LNA_modification

<400>  135
ggttgatttt gcggta                                                       16


<210>  136
<211>  16
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antisense_sequence_5-3_partially_with_phosphorothioate_linkages
       _ [*]_and_LNA_modifications_[+] (see Misc_Features)


<220>
<221>  misc_feature
<222>  (1)..(3)
<223>  LNA_modification

<220>
<221>  misc_feature
<222>  (1)..(16)
<223>  phosphorothioate_linkages

<220>
<221>  misc_feature
<222>  (14)..(16)
<223>  LNA_modification

<400>  136
tggttgattt tgcggt                                                       16


<210>  137
<211>  16
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antisense_sequence_5-3_partially_with_phosphorothioate_linkages
       _ [*]_and_LNA_modifications_[+] (see Misc_Features)


<220>
<221>  misc_feature
<222>  (1)..(3)
<223>  LNA_modification

<220>
<221>  misc_feature
<222>  (1)..(17)
<223>  phosphorothioate_linkages

<220>
<221>  misc_feature
<222>  (15)..(17)
<223>  LNA_modification

<400>  137
tgtgtatcat ttcggt                                                       16


<210>  138
<211>  16
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antisense_sequence_5-3_partially_with_phosphorothioate_linkages
       _ [*]_and_LNA_modifications_[+] (see Misc_Features)


<220>
<221>  misc_feature
<222>  (1)..(3)
<223>  LNA_modification

<220>
<221>  misc_feature
<222>  (1)..(17)
<223>  phosphorothioate_linkages

<220>
<221>  misc_feature
<222>  (15)..(17)
<223>  LNA_modification

<400>  138
cttacgtctc ctcgaa                                                       16


<210>  139
<211>  16
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antisense_sequence_5-3_partially_with_phosphorothioate_linkages
       _ [*]_and_LNA_modifications_[+] (see Misc_Features)


<220>
<221>  misc_feature
<222>  (1)..(3)
<223>  LNA_modification

<220>
<221>  misc_feature
<222>  (1)..(17)
<223>  phosphorothioate_linkages

<220>
<221>  misc_feature
<222>  (15)..(17)
<223>  LNA_modification

<400>  139
caacactgct tacgtc                                                       16


<210>  140
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antisense_sequence_5-3_partially_with_phosphorothioate_linkages
       _ [*]_and_LNA_modifications_[+] (see Misc_Features)


<220>
<221>  misc_feature
<222>  (1)..(3)
<223>  LNA_modification

<220>
<221>  misc_feature
<222>  (1)..(17)
<223>  phosphorothioate_linkages

<220>
<221>  misc_feature
<222>  (16)..(17)
<223>  LNA_modification

<400>  140
ttcgcttgta gtccg                                                        15


<210>  141
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antisense_sequence_5-3_partially_with_phosphorothioate_linkages
       _ [*]_and_LNA_modifications_[+] (see Misc_Features)


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  LNA_modification

<220>
<221>  misc_feature
<222>  (1)..(17)
<223>  phosphorothioate_linkages

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  LNA_modification

<220>
<221>  misc_feature
<222>  (15)..(17)
<223>  LNA_modification

<400>  141
gattcgcttg tagtc                                                        15


<210>  142
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antisense_sequence_5-3_partially_with_phosphorothioate_linkages
       _ [*]_and_LNA_modifications_[+] (see Misc_Features)


<220>
<221>  misc_feature
<222>  (1)..(3)
<223>  LNA_modification

<220>
<221>  misc_feature
<222>  (1)..(17)
<223>  phosphorothioate_linkages

<220>
<221>  misc_feature
<222>  (15)..(17)
<223>  LNA_modification

<400>  142
tgattcgctt gtagt                                                        15


<210>  143
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antisense_sequence_5-3_partially_with_phosphorothioate_linkages
       _ [*]_and_LNA_modifications_[+] (see Misc_Features)


<220>
<221>  misc_feature
<222>  (1)..(3)
<223>  LNA_modification

<220>
<221>  misc_feature
<222>  (1)..(17)
<223>  phosphorothioate_linkages

<220>
<221>  misc_feature
<222>  (15)..(17)
<223>  LNA_modification

<400>  143
ttacgtctcc tcgaa                                                        15


<210>  144
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antisense_sequence_5-3_partially_with_phosphorothioate_linkages
       _ [*]_and_LNA_modifications_[+] (see Misc_Features)


<220>
<221>  misc_feature
<222>  (1)..(3)
<223>  LNA_modification

<220>
<221>  misc_feature
<222>  (1)..(17)
<223>  phosphorothioate_linkages

<220>
<221>  misc_feature
<222>  (15)..(17)
<223>  LNA_modification

<400>  144
cttacgtctc ctcga                                                        15


<210>  145
<211>  17
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antisense_sequence_5-3_partially_with_phosphorothioate_linkages
       _ [*]_and_LNA_modifications_[+] (see Misc_Features)


<220>
<221>  misc_feature
<222>  (1)..(3)
<223>  LNA_modification

<220>
<221>  misc_feature
<222>  (1)..(18)
<223>  phosphorothioate_linkages

<220>
<221>  misc_feature
<222>  (16)..(18)
<223>  LNA_modification

<400>  145
tctatcgtga tgtttct                                                      17


<210>  146
<211>  17
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antisense_sequence_5-3_partially_with_phosphorothioate_linkages
       _ [*]_and_LNA_modifications_[+] (see Misc_Features)


<220>
<221>  misc_feature
<222>  (1)..(3)
<223>  LNA_modification

<220>
<221>  misc_feature
<222>  (1)..(17)
<223>  phosphorothioate_linkages

<220>
<221>  misc_feature
<222>  (15)..(17)
<223>  LNA_modification

<400>  146
tctatcgtga tgtttct                                                      17


