                         SEQUENCE LISTING

<110>  BAYLOR COLLEGE OF MEDICINE
 
<120>  CHIMERIC ANTIGEN RECEPTOR THERAPY WITH REDUCED CYTOTOXICITY FOR 
       VIRAL DISEASE

<130>  BAYM.P0188WO

<140>  PCT/US2017/054556
<141>  2017-09-29

<150>  62402731
<151>  2016-09-30

<150>  62473668
<151>  2017-03-20

<160>  19    

<170>  PatentIn version 3.5

<210>  1
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Peptide

<400>  1

Ser Gly Ser Gly Leu Lys Lys Lys Trp Ser Thr 
1               5                   10      


<210>  2
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Peptide

<400>  2

Cys Glu Thr Gly Ala Lys Pro His Cys 
1               5                   


<210>  3
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Peptide

<400>  3

Lys His Met His Trp His Pro Pro Ala Leu Asn Thr 
1               5                   10          


<210>  4
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Peptide

<400>  4

Ser Gly Ser Gly Trp Thr Asn Trp Trp Ser Thr 
1               5                   10      


<210>  5
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Peptide

<400>  5

Asn Asn Trp Trp Tyr Trp Trp Asp Thr Leu Val Asn 
1               5                   10          


<210>  6
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Peptide

<400>  6

Gly Leu Trp Arg Phe Trp Phe Gly Asp Phe Leu Thr 
1               5                   10          


<210>  7
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Peptide

<400>  7

Trp Thr Asp Met Phe Thr Ala Trp Trp Ser Thr Pro 
1               5                   10          


<210>  8
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Peptide

<400>  8

Leu Arg Asn Ile Arg Leu Arg Asn Ile Arg Leu Arg Asn Ile Arg Leu 
1               5                   10                  15      


Arg Asn Ile Arg 
            20  


<210>  9
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Peptide

<400>  9

Cys Ser Arg Leu Leu Tyr Gly Trp Cys 
1               5                   


<210>  10
<211>  638
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Peptide

<400>  10

Met Asp Trp Ile Trp Arg Ile Leu Phe Leu Val Gly Ala Ala Thr Gly 
1               5                   10                  15      


Ala His Ser Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln 
            20                  25                  30          


Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Pro Ser Gly Phe Val Phe 
        35                  40                  45              


Arg Ser Tyr Gly Met His Trp Val Arg Gln Thr Pro Gly Lys Gly Leu 
    50                  55                  60                  


Glu Trp Val Ser Leu Ile Trp His Asp Gly Ser Asn Arg Phe Tyr Ala 
65                  70                  75                  80  


Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn 
                85                  90                  95      


Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Met 
            100                 105                 110         


Tyr Phe Cys Ala Arg Glu Arg Leu Ile Ala Ala Pro Ala Ala Phe Asp 
        115                 120                 125             


Leu Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly 
    130                 135                 140                 


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ser Tyr Val Leu Thr 
145                 150                 155                 160 


Gln Pro Pro Ser Val Ser Val Ala Pro Gly Lys Thr Ala Arg Ile Ser 
                165                 170                 175     


Cys Gly Gly Asn Asn Ile Gly Thr Lys Asn Val His Trp Tyr Gln Gln 
            180                 185                 190         


Lys Pro Gly Gln Ala Pro Val Leu Val Val Tyr Ala Asp Ser Asp Arg 
        195                 200                 205             


Pro Ser Gly Ile Pro Glu Arg Phe Ser Gly Ser Asn Ser Gly Asn Thr 
    210                 215                 220                 


Ala Thr Leu Thr Ile Ser Arg Val Glu Val Gly Asp Glu Ala Asp Tyr 
225                 230                 235                 240 


Tyr Cys Gln Val Trp Asp Ser Val Ser Tyr His Val Val Phe Gly Gly 
                245                 250                 255     


Gly Thr Thr Leu Thr Val Leu Gly Ser Gly Gly Gly Gly Ser Glu Ser 
            260                 265                 270         


Lys Tyr Gly Pro Pro Cys Pro Ser Cys Pro Ala Pro Pro Val Ala Gly 
        275                 280                 285             


Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile 
    290                 295                 300                 


Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser Gln Glu 
305                 310                 315                 320 


Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His 
                325                 330                 335     


Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Gln Ser Thr Tyr Arg 
            340                 345                 350         


Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys 
        355                 360                 365             


Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu 
    370                 375                 380                 


Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr 
385                 390                 395                 400 


Thr Leu Pro Pro Ser Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu 
                405                 410                 415     


Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp 
            420                 425                 430         


Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val 
        435                 440                 445             


Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp 
    450                 455                 460                 


Lys Ser Arg Trp Gln Glu Gly Asn Val Phe Ser Cys Ser Val Met His 
465                 470                 475                 480 


Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro 
                485                 490                 495     


Gly Lys Lys Asp Pro Lys Phe Trp Val Leu Val Val Val Gly Gly Val 
            500                 505                 510         


Leu Ala Cys Tyr Ser Leu Leu Val Thr Val Ala Phe Ile Ile Arg Val 
        515                 520                 525             


Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn 
    530                 535                 540                 


Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val 
545                 550                 555                 560 


Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg 
                565                 570                 575     


Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys 
            580                 585                 590         


Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg 
        595                 600                 605             


Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys 
    610                 615                 620                 


Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
625                 630                 635             


<210>  11
<211>  606
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Peptide

<400>  11

Met Asp Trp Ile Trp Arg Ile Leu Phe Leu Val Gly Ala Ala Thr Gly 
1               5                   10                  15      


Ala His Ser Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln 
            20                  25                  30          


Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Pro Ser Gly Phe Val Phe 
        35                  40                  45              


Arg Ser Tyr Gly Met His Trp Val Arg Gln Thr Pro Gly Lys Gly Leu 
    50                  55                  60                  


Glu Trp Val Ser Leu Ile Trp His Asp Gly Ser Asn Arg Phe Tyr Ala 
65                  70                  75                  80  


Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn 
                85                  90                  95      


Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Met 
            100                 105                 110         


Tyr Phe Cys Ala Arg Glu Arg Leu Ile Ala Ala Pro Ala Ala Phe Asp 
        115                 120                 125             


Leu Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly 
    130                 135                 140                 


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ser Tyr Val Leu Thr 
145                 150                 155                 160 


Gln Pro Pro Ser Val Ser Val Ala Pro Gly Lys Thr Ala Arg Ile Ser 
                165                 170                 175     


Cys Gly Gly Asn Asn Ile Gly Thr Lys Asn Val His Trp Tyr Gln Gln 
            180                 185                 190         


Lys Pro Gly Gln Ala Pro Val Leu Val Val Tyr Ala Asp Ser Asp Arg 
        195                 200                 205             


Pro Ser Gly Ile Pro Glu Arg Phe Ser Gly Ser Asn Ser Gly Asn Thr 
    210                 215                 220                 


Ala Thr Leu Thr Ile Ser Arg Val Glu Val Gly Asp Glu Ala Asp Tyr 
225                 230                 235                 240 


Tyr Cys Gln Val Trp Asp Ser Val Ser Tyr His Val Val Phe Gly Gly 
                245                 250                 255     


Gly Thr Thr Leu Thr Val Leu Gly Ser Gly Gly Gly Gly Ser Glu Ser 
            260                 265                 270         


Lys Tyr Gly Pro Pro Cys Pro Ser Cys Pro Ala Pro Pro Val Ala Gly 
        275                 280                 285             


Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile 
    290                 295                 300                 


Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser Gln Glu 
305                 310                 315                 320 


Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His 
                325                 330                 335     


Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Gln Ser Thr Tyr Arg 
            340                 345                 350         


Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys 
        355                 360                 365             


Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu 
    370                 375                 380                 


Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr 
385                 390                 395                 400 


Thr Leu Pro Pro Ser Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu 
                405                 410                 415     


Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp 
            420                 425                 430         


Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val 
        435                 440                 445             


Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp 
    450                 455                 460                 


Lys Ser Arg Trp Gln Glu Gly Asn Val Phe Ser Cys Ser Val Met His 
465                 470                 475                 480 


Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro 
                485                 490                 495     


Gly Lys Lys Asp Pro Lys Phe Trp Val Leu Val Val Val Gly Gly Val 
            500                 505                 510         


Leu Ala Cys Tyr Ser Leu Leu Val Thr Val Ala Phe Ile Ile Phe Trp 
        515                 520                 525             


Val Arg Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met Asn Met 
    530                 535                 540                 


Thr Pro Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala 
545                 550                 555                 560 


Pro Pro Arg Asp Phe Ala Ala Tyr Arg Ser Arg Asp Gln Arg Leu Pro 
                565                 570                 575     


Pro Asp Ala His Lys Pro Pro Gly Gly Gly Ser Phe Arg Thr Pro Ile 
            580                 585                 590         


Gln Glu Glu Gln Ala Asp Ala His Ser Thr Leu Ala Lys Ile 
        595                 600                 605     


<210>  12
<211>  650
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Peptide

<400>  12

Met Asp Trp Ile Trp Arg Ile Leu Phe Leu Val Gly Ala Ala Thr Gly 
1               5                   10                  15      


Ala His Ser Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Arg 
            20                  25                  30          


Pro Gly Arg Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ala Phe 
        35                  40                  45              


Ser Asp Tyr Ser Ile Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu 
    50                  55                  60                  


Glu Trp Val Ala Ile Ile Ser Tyr Asp Gly Arg Ile Thr Tyr Tyr Arg 
65                  70                  75                  80  


Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn 
                85                  90                  95      


Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Thr Glu Asp Thr Ala Val 
            100                 105                 110         


Tyr Tyr Cys Ala Arg Gln Tyr Tyr Asp Phe Trp Ser Gly Ser Ser Val 
        115                 120                 125             


Gly Arg Asn Tyr Asp Gly Met Asp Val Trp Gly Leu Gly Thr Thr Val 
    130                 135                 140                 


Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
145                 150                 155                 160 


Gly Gly Ser Asp Ile Val Met Thr Gln Ser Pro Leu Ser Leu Ser Val 
                165                 170                 175     


Thr Pro Gly Glu Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu 
            180                 185                 190         


Leu His Arg Ser Gly Asn Asn Tyr Leu Asp Trp Tyr Leu Gln Lys Pro 
        195                 200                 205             


Gly His Ser Pro Gln Leu Leu Ile Tyr Val Gly Ser Asn Arg Ala Ser 
    210                 215                 220                 


Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Glu Tyr Thr 
225                 230                 235                 240 


Leu Arg Ile Ser Thr Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys 
                245                 250                 255     


Met Gln Ala Leu Gln Thr Pro Arg Thr Phe Gly Gln Gly Thr Lys Leu 
            260                 265                 270         


Glu Ile Lys Arg Ser Gly Gly Gly Gly Ser Glu Ser Lys Tyr Gly Pro 
        275                 280                 285             


Pro Cys Pro Ser Cys Pro Ala Pro Pro Val Ala Gly Pro Ser Val Phe 
    290                 295                 300                 


Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro 
305                 310                 315                 320 


Glu Val Thr Cys Val Val Val Asp Val Ser Gln Glu Asp Pro Glu Val 
                325                 330                 335     


Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr 
            340                 345                 350         


Lys Pro Arg Glu Glu Gln Phe Gln Ser Thr Tyr Arg Val Val Ser Val 
        355                 360                 365             


Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys 
    370                 375                 380                 


Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile Ser 
385                 390                 395                 400 


Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro 
                405                 410                 415     


Ser Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val 
            420                 425                 430         


Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly 
        435                 440                 445             


Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp 
    450                 455                 460                 


Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg Trp 
465                 470                 475                 480 


Gln Glu Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His 
                485                 490                 495     


Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys Lys Asp 
            500                 505                 510         


Pro Lys Phe Trp Val Leu Val Val Val Gly Gly Val Leu Ala Cys Tyr 
        515                 520                 525             


Ser Leu Leu Val Thr Val Ala Phe Ile Ile Arg Val Lys Phe Ser Arg 
    530                 535                 540                 


Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn 
545                 550                 555                 560 


Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg 
                565                 570                 575     


Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro 
            580                 585                 590         


Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala 
        595                 600                 605             


Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His 
    610                 615                 620                 


Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp 
625                 630                 635                 640 


Ala Leu His Met Gln Ala Leu Pro Pro Arg 
                645                 650 


<210>  13
<211>  638
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Peptide

<400>  13

Met Glu Phe Gly Leu Ser Trp Val Phe Leu Val Ala Leu Leu Arg Gly 
1               5                   10                  15      


Val Gln Cys Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln 
            20                  25                  30          


Pro Gly Arg Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe 
        35                  40                  45              


Ser Arg Tyr Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu 
    50                  55                  60                  


Glu Trp Val Ala Val Ile Ser Tyr Asp Gly Ser Asn Lys Trp Tyr Ala 
65                  70                  75                  80  


Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn 
                85                  90                  95      


Thr Leu Phe Leu Gln Met His Ser Leu Arg Ala Ala Asp Thr Gly Val 
            100                 105                 110         


Tyr Tyr Cys Ala Lys Asp Gln Leu Tyr Phe Gly Ser Gln Ser Pro Gly 
        115                 120                 125             


His Tyr Trp Val Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly 
    130                 135                 140                 


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Ser Gln Leu 
145                 150                 155                 160 


Thr Gln Pro Pro Ser Val Ser Val Ala Pro Gly Gln Thr Ala Arg Ile 
                165                 170                 175     


Thr Cys Gly Gly Asp Asn Ile Gly Ser Lys Ser Val Asn Trp Phe Gln 
            180                 185                 190         


Gln Lys Pro Gly Gln Ala Pro Val Leu Val Val Tyr Asp Asp Asn Glu 
        195                 200                 205             


Arg Pro Ser Gly Ile Ser Glu Arg Phe Ser Gly Ser Asn Ser Gly Asn 
    210                 215                 220                 


Thr Ala Thr Leu Thr Ile Ser Arg Val Glu Ala Gly Asp Glu Ala Asp 
225                 230                 235                 240 


Tyr Tyr Cys Gln Val Trp Asp Ser Ser Ser Asp His Val Val Phe Gly 
                245                 250                 255     


Gly Gly Thr Lys Leu Thr Val Leu Ser Gly Gly Gly Gly Ser Glu Ser 
            260                 265                 270         


Lys Tyr Gly Pro Pro Cys Pro Ser Cys Pro Ala Pro Pro Val Ala Gly 
        275                 280                 285             


Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile 
    290                 295                 300                 


Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser Gln Glu 
305                 310                 315                 320 


Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His 
                325                 330                 335     


Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Gln Ser Thr Tyr Arg 
            340                 345                 350         


Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys 
        355                 360                 365             


Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu 
    370                 375                 380                 


Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr 
385                 390                 395                 400 


Thr Leu Pro Pro Ser Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu 
                405                 410                 415     


Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp 
            420                 425                 430         


Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val 
        435                 440                 445             


Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp 
    450                 455                 460                 


Lys Ser Arg Trp Gln Glu Gly Asn Val Phe Ser Cys Ser Val Met His 
465                 470                 475                 480 


Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro 
                485                 490                 495     


Gly Lys Lys Asp Pro Lys Phe Trp Val Leu Val Val Val Gly Gly Val 
            500                 505                 510         


Leu Ala Cys Tyr Ser Leu Leu Val Thr Val Ala Phe Ile Ile Arg Val 
        515                 520                 525             


Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn 
    530                 535                 540                 


Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val 
545                 550                 555                 560 


Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg 
                565                 570                 575     


Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys 
            580                 585                 590         


Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg 
        595                 600                 605             


Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys 
    610                 615                 620                 


Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
625                 630                 635             


<210>  14
<211>  47
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Primer

<400>  14
gacccaccag gaccagtacc tacacaaagt actggtcctg gtgggtc                     47


<210>  15
<211>  84
<212>  RNA
<213>  Homo sapiens

<400>  15
cuccccaugg cccugucucc caacccuugu accagugcug ggcucagacc cugguacagg       60

ccugggggac agggaccugg ggac                                              84


<210>  16
<211>  78
<212>  RNA
<213>  Homo sapiens

<400>  16
cugaggagca gggcuuagcu gcuugugagc aggguccaca ccaagucgug uucacagugg       60

cuaaguuccg ccccccag                                                     78


<210>  17
<211>  240
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Peptide

<400>  17

Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Gly 
1               5                   10                  15      


Ser Gly Phe Gln Lys Ala Ser Ser Ile Val Tyr Lys Lys Glu Gly Glu 
            20                  25                  30          


Gln Val Glu Phe Ser Phe Pro Leu Ala Phe Thr Val Glu Lys Leu Thr 
        35                  40                  45              


Gly Ser Gly Glu Leu Trp Trp Gln Ala Glu Arg Ala Ser Ser Ser Lys 
    50                  55                  60                  


Ser Trp Ile Thr Phe Asp Leu Lys Asn Lys Glu Val Ser Val Lys Arg 
65                  70                  75                  80  


Val Thr Gln Asp Pro Lys Leu Gln Met Gly Lys Lys Leu Pro Leu His 
                85                  90                  95      


Leu Thr Leu Pro Gln Ala Leu Pro Gln Tyr Ala Gly Ser Gly Asn Leu 
            100                 105                 110         


Thr Leu Ala Leu Glu Ala Lys Thr Gly Lys Leu His Gln Glu Val Asn 
        115                 120                 125             


Leu Val Val Met Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 
    130                 135                 140                 


Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu 
145                 150                 155                 160 


Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 
                165                 170                 175     


Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser 
            180                 185                 190         


Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg 
        195                 200                 205             


Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 
    210                 215                 220                 


His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys Lys 
225                 230                 235                 240 


<210>  18
<211>  690
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Primer

<400>  18
ggatccgaga gtaaatacgg gccgccatgt ccttcctgcc cagccccgcc cgtggctggc       60

ccctccgttt tcctattccc tcccaagccg aaggatacct tgatgatctc acgcacgcca      120

gaggttactt gcgtcgtcgt tgatgtttca caggaagatc ctgaggtcca atttaactgg      180

tatgtagatg gagtcgaggt gcataacgca aagacgaaac cgcgggaaga gcagttccaa      240

tcaacttaca gggtggtgag tgtcctgaca gtgttacacc aggactggct caacgggaag      300

gagtacaagt gcaaagtaag taacaaggga ctgcccagct ctatcgagaa aacaatttcc      360

aaggccaagg gtcagccacg agaaccacaa gtctacacac tccccccctc gcaggaagaa      420

atgaccaaga atcaggtaag cctgacatgt cttgtcaaag gcttctatcc aagcgacatc      480

gcggtggagt gggagtccaa tggacagccc gaaaacaact ataaaaccac ccctccagtg      540

ctggacagcg acggctcctt ttttctttat agcagactga ccgtggacaa atctcggtgg      600

caggaaggta atgtgttttc ttgtagcgtg atgcatgagg ctctgcacaa ccactacacg      660

cagaagagcc tctccctgtc tccgggtaaa                                       690


<210>  19
<211>  230
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Peptide

<400>  19

Gly Ser Glu Ser Lys Tyr Gly Pro Pro Cys Pro Ser Cys Pro Ala Pro 
1               5                   10                  15      


Pro Val Ala Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp 
            20                  25                  30          


Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp 
        35                  40                  45              


Val Ser Gln Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly 
    50                  55                  60                  


Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Gln 
65                  70                  75                  80  


Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp 
                85                  90                  95      


Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro 
            100                 105                 110         


Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu 
        115                 120                 125             


Pro Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met Thr Lys Asn 
    130                 135                 140                 


Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile 
145                 150                 155                 160 


Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr 
                165                 170                 175     


Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Arg 
            180                 185                 190         


Leu Thr Val Asp Lys Ser Arg Trp Gln Glu Gly Asn Val Phe Ser Cys 
        195                 200                 205             


Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu 
    210                 215                 220                 


Ser Leu Ser Pro Gly Lys 
225                 230 


