                         SEQUENCE LISTING

<110>  Regeneron Pharmaceuticals, Inc
       Heslin, David
       Ally, Roxanne
       Siao, Chia-Jen
       Lai, Ka-Man Venus
       Valenzuela, David M.
       Guo, Chunguang
       LaCroix-Fralish, Michael
       Macdonald, Lynn
       Sharma, Aarti
       Kajimura, Daisuke
       Droguett, Gustavo
       Frendewey, David
 
<120>  NON-HUMAN ANIMALS HAVING A HEXANUCLEOTIDE REPEAT EXPANSION IN A 
       C9ORF72 LOCUS

<130>  017283.1366/10267WO01

<150>  62402613
<151>  2016-09-30

<150>  62452795
<151>  2017-01-31

<160>  84    

<170>  PatentIn version 3.5

<210>  1
<211>  6
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Heterologous Hexanucleotide sequence

<400>  1
ggggcc                                                                   6


<210>  2
<211>  964
<212>  DNA
<213>  Homo sapiens

<400>  2
gggtctagca agagcaggtg tgggtttagg aggtgtgtgt ttttgttttt cccaccctct       60

ctccccacta cttgctctca cagtactcgc tgagggtgaa caagaaaaga cctgataaag      120

attaaccaga agaaaacaag gagggaaaca accgcagcct gtagcaagct ctggaactca      180

ggagtcgcgc gctatgcgat cgcggggccg gggccggggc cgcgatcgcg gggcgtggtc      240

ggggcgggcc cgggggcggg cccggggcgg ggctgcggtt gcggtgcctg cgcccgcggc      300

ggcggaggcg caggcggtgg cgagtgggtg agtgaggagg cggcatcctg gcgggtggct      360

gtttggggtt cggctgccgg gaagaggcgc gggtagaagc gggggctctc ctcagagctc      420

gacgcatttt tactttccct ctcatttctc tgaccgaagc tgggtgtcgg gctttcgcct      480

ctagcgactg gtggaattgc ctgcatccgg gccccgggct tcccggcggc ggcggcggcg      540

gcggcggcgc agggacaagg gatggggatc tggcctcttc cttgctttcc cgccctcagt      600

acccgagctg tctccttccc ggggacccgc tgggagcgct gccgctgcgg gctcgagaaa      660

agggagcctc gggtactgag aggcctcgcc tgggggaagg ccggagggtg ggcggcgcgc      720

ggcttctgcg gaccaagtcg gggttcgcta ggaacccgag acggtccctg ccggcgagga      780

gatcatgcgg gatgagatgg gggtgtggag acgcctgcac aatttcagcc caagcttcta      840

gagagtggtg atgacttgca tatgagggca gcaatgcaag tcggtgtgct ccccattctg      900

tgggacatga cctggttgct tcacagctcc gagatgacac agacttgctt aaaggaagtg      960

actc                                                                   964


<210>  3
<211>  1528
<212>  DNA
<213>  Homo sapiens

<400>  3
gggtctagca agagcaggtg tgggtttagg aggtgtgtgt ttttgttttt cccaccctct       60

ctccccacta cttgctctca cagtactcgc tgagggtgaa caagaaaaga cctgataaag      120

attaaccaga agaaaacaag gagggaaaca accgcagcct gtagcaagct ctggaactca      180

ggagtcgcgc gctatgcgat cgccgtctcg gggccggggc cggggccggg gccggggccg      240

gggccggggc cggggccggg gccggggccg gggccggggc cggggccggg gccggggccg      300

gggccggggc cggggccggg gccggggccg gggccggggc cggggccggg gccggggccg      360

gggccggggc cggggccggg gccggggccg gggccggggc cggggccggg gccggggccg      420

gggccggggc cggggccggg gccggggccg gggccggggc cggggccggg gccggggccg      480

gggccggggc cggggccggg gccggggccg gggccggggc cggggccggg gccggggccg      540

gggccggggc cggggccggg gccggggccg gggccggggc cggggccggg gccggggccg      600

gggccggggc cggggccggg gccggggccg gggccggggc cggggccggg gccggggccg      660

gggccggggc cggggccggg gccggggccg gggccggggc cggggccggg gccggggccg      720

gggccggggc cggggccggg gccggggccg gggccggggc cgagaccctc gagggccggc      780

cgctagcgcg atcgcggggc gtggtcgggg cgggcccggg ggcgggcccg gggcggggct      840

gcggttgcgg tgcctgcgcc cgcggcggcg gaggcgcagg cggtggcgag tgggtgagtg      900

aggaggcggc atcctggcgg gtggctgttt ggggttcggc tgccgggaag aggcgcgggt      960

agaagcgggg gctctcctca gagctcgacg catttttact ttccctctca tttctctgac     1020

cgaagctggg tgtcgggctt tcgcctctag cgactggtgg aattgcctgc atccgggccc     1080

cgggcttccc ggcggcggcg gcggcggcgg cggcgcaggg acaagggatg gggatctggc     1140

ctcttccttg ctttcccgcc ctcagtaccc gagctgtctc cttcccgggg acccgctggg     1200

agcgctgccg ctgcgggctc gagaaaaggg agcctcgggt actgagaggc ctcgcctggg     1260

ggaaggccgg agggtgggcg gcgcgcggct tctgcggacc aagtcggggt tcgctaggaa     1320

cccgagacgg tccctgccgg cgaggagatc atgcgggatg agatgggggt gtggagacgc     1380

ctgcacaatt tcagcccaag cttctagaga gtggtgatga cttgcatatg agggcagcaa     1440

tgcaagtcgg tgtgctcccc attctgtggg acatgacctg gttgcttcac agctccgaga     1500

tgacacagac ttgcttaaag gaagtgac                                        1528


<210>  4
<211>  3621
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  8026 insert nucleic acid without homology arms

<400>  4
gggtctagca agagcaggtg tgggtttagg aggtgtgtgt ttttgttttt cccaccctct       60

ctccccacta cttgctctca cagtactcgc tgagggtgaa caagaaaaga cctgataaag      120

attaaccaga agaaaacaag gagggaaaca accgcagcct gtagcaagct ctggaactca      180

ggagtcgcgc gctatgcgat cgcggggccg gggccggggc cgcgatcgcg gggcgtggtc      240

ggggcgggcc cgggggcggg cccggggcgg ggctgcggtt gcggtgcctg cgcccgcggc      300

ggcggaggcg caggcggtgg cgagtgggtg agtgaggagg cggcatcctg gcgggtggct      360

gtttggggtt cggctgccgg gaagaggcgc gggtagaagc gggggctctc ctcagagctc      420

gacgcatttt tactttccct ctcatttctc tgaccgaagc tgggtgtcgg gctttcgcct      480

ctagcgactg gtggaattgc ctgcatccgg gccccgggct tcccggcggc ggcggcggcg      540

gcggcggcgc agggacaagg gatggggatc tggcctcttc cttgctttcc cgccctcagt      600

acccgagctg tctccttccc ggggacccgc tgggagcgct gccgctgcgg gctcgagaaa      660

agggagcctc gggtactgag aggcctcgcc tgggggaagg ccggagggtg ggcggcgcgc      720

ggcttctgcg gaccaagtcg gggttcgcta ggaacccgag acggtccctg ccggcgagga      780

gatcatgcgg gatgagatgg gggtgtggag acgcctgcac aatttcagcc caagcttcta      840

gagagtggtg atgacttgca tatgagggca gcaatgcaag tcggtgtgct ccccattctg      900

tgggacatga cctggttgct tcacagctcc gagatgacac agacttgctt aaaggaagtg      960

actcgagata acttcgtata atgtatgcta tacgaagtta tatgcatggc ctccgcgccg     1020

ggttttggcg cctcccgcgg gcgcccccct cctcacggcg agcgctgcca cgtcagacga     1080

agggcgcagc gagcgtcctg atccttccgc ccggacgctc aggacagcgg cccgctgctc     1140

ataagactcg gccttagaac cccagtatca gcagaaggac attttaggac gggacttggg     1200

tgactctagg gcactggttt tctttccaga gagcggaaca ggcgaggaaa agtagtccct     1260

tctcggcgat tctgcggagg gatctccgtg gggcggtgaa cgccgatgat tatataagga     1320

cgcgccgggt gtggcacagc tagttccgtc gcagccggga tttgggtcgc ggttcttgtt     1380

tgtggatcgc tgtgatcgtc acttggtgag tagcgggctg ctgggctggc cggggctttc     1440

gtggccgccg ggccgctcgg tgggacggaa gcgtgtggag agaccgccaa gggctgtagt     1500

ctgggtccgc gagcaaggtt gccctgaact gggggttggg gggagcgcag caaaatggcg     1560

gctgttcccg agtcttgaat ggaagacgct tgtgaggcgg gctgtgaggt cgttgaaaca     1620

aggtgggggg catggtgggc ggcaagaacc caaggtcttg aggccttcgc taatgcggga     1680

aagctcttat tcgggtgaga tgggctgggg caccatctgg ggaccctgac gtgaagtttg     1740

tcactgactg gagaactcgg tttgtcgtct gttgcggggg cggcagttat ggcggtgccg     1800

ttgggcagtg cacccgtacc tttgggagcg cgcgccctcg tcgtgtcgtg acgtcacccg     1860

ttctgttggc ttataatgca gggtggggcc acctgccggt aggtgtgcgg taggcttttc     1920

tccgtcgcag gacgcagggt tcgggcctag ggtaggctct cctgaatcga caggcgccgg     1980

acctctggtg aggggaggga taagtgaggc gtcagtttct ttggtcggtt ttatgtacct     2040

atcttcttaa gtagctgaag ctccggtttt gaactatgcg ctcggggttg gcgagtgtgt     2100

tttgtgaagt tttttaggca ccttttgaaa tgtaatcatt tgggtcaata tgtaattttc     2160

agtgttagac tagtaaattg tccgctaaat tctggccgtt tttggctttt ttgttagacg     2220

tgttgacaat taatcatcgg catagtatat cggcatagta taatacgaca aggtgaggaa     2280

ctaaaccatg ggatcggcca ttgaacaaga tggattgcac gcaggttctc cggccgcttg     2340

ggtggagagg ctattcggct atgactgggc acaacagaca atcggctgct ctgatgccgc     2400

cgtgttccgg ctgtcagcgc aggggcgccc ggttcttttt gtcaagaccg acctgtccgg     2460

tgccctgaat gaactgcagg acgaggcagc gcggctatcg tggctggcca cgacgggcgt     2520

tccttgcgca gctgtgctcg acgttgtcac tgaagcggga agggactggc tgctattggg     2580

cgaagtgccg gggcaggatc tcctgtcatc tcaccttgct cctgccgaga aagtatccat     2640

catggctgat gcaatgcggc ggctgcatac gcttgatccg gctacctgcc cattcgacca     2700

ccaagcgaaa catcgcatcg agcgagcacg tactcggatg gaagccggtc ttgtcgatca     2760

ggatgatctg gacgaagagc atcaggggct cgcgccagcc gaactgttcg ccaggctcaa     2820

ggcgcgcatg cccgacggcg atgatctcgt cgtgacccat ggcgatgcct gcttgccgaa     2880

tatcatggtg gaaaatggcc gcttttctgg attcatcgac tgtggccggc tgggtgtggc     2940

ggaccgctat caggacatag cgttggctac ccgtgatatt gctgaagagc ttggcggcga     3000

atgggctgac cgcttcctcg tgctttacgg tatcgccgct cccgattcgc agcgcatcgc     3060

cttctatcgc cttcttgacg agttcttctg aggggatccg ctgtaagtct gcagaaattg     3120

atgatctatt aaacaataaa gatgtccact aaaatggaag tttttcctgt catactttgt     3180

taagaagggt gagaacagag tacctacatt ttgaatggaa ggattggagc tacgggggtg     3240

ggggtggggt gggattagat aaatgcctgc tctttactga aggctcttta ctattgcttt     3300

atgataatgt ttcatagttg gatatcataa tttaaacaag caaaaccaaa ttaagggcca     3360

gctcattcct cccactcatg atctatagat ctatagatct ctcgtgggat cattgttttt     3420

ctcttgattc ccactttgtg gttctaagta ctgtggtttc caaatgtgtc agtttcatag     3480

cctgaagaac gagatcagca gcctctgttc cacatacact tcattctcag tattgttttg     3540

ccaagttcta attccatcag acctcgacct gcagccccta gataacttcg tataatgtat     3600

gctatacgaa gttatgctag c                                               3621


<210>  5
<211>  1006
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  8026 insert nucleic acid without homology arms and after excision
       of neo

<400>  5
gggtctagca agagcaggtg tgggtttagg aggtgtgtgt ttttgttttt cccaccctct       60

ctccccacta cttgctctca cagtactcgc tgagggtgaa caagaaaaga cctgataaag      120

attaaccaga agaaaacaag gagggaaaca accgcagcct gtagcaagct ctggaactca      180

ggagtcgcgc gctatgcgat cgcggggccg gggccggggc cgcgatcgcg gggcgtggtc      240

ggggcgggcc cgggggcggg cccggggcgg ggctgcggtt gcggtgcctg cgcccgcggc      300

ggcggaggcg caggcggtgg cgagtgggtg agtgaggagg cggcatcctg gcgggtggct      360

gtttggggtt cggctgccgg gaagaggcgc gggtagaagc gggggctctc ctcagagctc      420

gacgcatttt tactttccct ctcatttctc tgaccgaagc tgggtgtcgg gctttcgcct      480

ctagcgactg gtggaattgc ctgcatccgg gccccgggct tcccggcggc ggcggcggcg      540

gcggcggcgc agggacaagg gatggggatc tggcctcttc cttgctttcc cgccctcagt      600

acccgagctg tctccttccc ggggacccgc tgggagcgct gccgctgcgg gctcgagaaa      660

agggagcctc gggtactgag aggcctcgcc tgggggaagg ccggagggtg ggcggcgcgc      720

ggcttctgcg gaccaagtcg gggttcgcta ggaacccgag acggtccctg ccggcgagga      780

gatcatgcgg gatgagatgg gggtgtggag acgcctgcac aatttcagcc caagcttcta      840

gagagtggtg atgacttgca tatgagggca gcaatgcaag tcggtgtgct ccccattctg      900

tgggacatga cctggttgct tcacagctcc gagatgacac agacttgctt aaaggaagtg      960

actcgagata acttcgtata atgtatgcta tacgaagtta tgctag                    1006


<210>  6
<211>  4180
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  8026 Insert Nucleic acid without homology arms plus neo cassette

<400>  6
ggtctagcaa gagcaggtgt gggtttagga ggtgtgtgtt tttgtttttc ccaccctctc       60

tccccactac ttgctctcac agtactcgct gagggtgaac aagaaaagac ctgataaaga      120

ttaaccagaa gaaaacaagg agggaaacaa ccgcagcctg tagcaagctc tggaactcag      180

gagtcgcgcg ctatgcgatc gccgtctcgg ggccggggcc ggggccgggg ccggggccgg      240

ggccggggcc ggggccgggg ccggggccgg ggccggggcc ggggccgggg ccggggccgg      300

ggccggggcc ggggccgggg ccggggccgg ggccggggcc ggggccgggg ccggggccgg      360

ggccggggcc ggggccgggg ccggggccgg ggccggggcc ggggccgggg ccggggccgg      420

ggccggggcc ggggccgggg ccggggccgg ggccggggcc ggggccgggg ccggggccgg      480

ggccggggcc ggggccgggg ccggggccgg ggccggggcc ggggccgggg ccggggccgg      540

ggccggggcc ggggccgggg ccggggccgg ggccggggcc ggggccgggg ccggggccgg      600

ggccggggcc ggggccgggg ccggggccgg ggccggggcc ggggccgggg ccggggccgg      660

ggccggggcc ggggccgggg ccggggccgg ggccggggcc ggggccgggg ccggggccgg      720

ggccggggcc ggggccgggg ccggggccgg ggccggggcc gagaccctcg agggccggcc      780

gctagcgcga tcgcggggcg tggtcggggc gggcccgggg gcgggcccgg ggcggggctg      840

cggttgcggt gcctgcgccc gcggcggcgg aggcgcaggc ggtggcgagt gggtgagtga      900

ggaggcggca tcctggcggg tggctgtttg gggttcggct gccgggaaga ggcgcgggta      960

gaagcggggg ctctcctcag agctcgacgc atttttactt tccctctcat ttctctgacc     1020

gaagctgggt gtcgggcttt cgcctctagc gactggtgga attgcctgca tccgggcccc     1080

gggcttcccg gcggcggcgg cggcggcggc ggcgcaggga caagggatgg ggatctggcc     1140

tcttccttgc tttcccgccc tcagtacccg agctgtctcc ttcccgggga cccgctggga     1200

gcgctgccgc tgcgggctcg agaaaaggga gcctcgggta ctgagaggcc tcgcctgggg     1260

gaaggccgga gggtgggcgg cgcgcggctt ctgcggacca agtcggggtt cgctaggaac     1320

ccgagacggt ccctgccggc gaggagatca tgcgggatga gatgggggtg tggagacgcc     1380

tgcacaattt cagcccaagc ttctagagag tggtgatgac ttgcatatga gggcagcaat     1440

gcaagtcggt gtgctcccca ttctgtggga catgacctgg ttgcttcaca gctccgagat     1500

gacacagact tgcttaaagg aagtgactcg agataacttc gtataatgta tgctatacga     1560

agttatatgc atggcctccg cgccgggttt tggcgcctcc cgcgggcgcc cccctcctca     1620

cggcgagcgc tgccacgtca gacgaagggc gcagcgagcg tcctgatcct tccgcccgga     1680

cgctcaggac agcggcccgc tgctcataag actcggcctt agaaccccag tatcagcaga     1740

aggacatttt aggacgggac ttgggtgact ctagggcact ggttttcttt ccagagagcg     1800

gaacaggcga ggaaaagtag tcccttctcg gcgattctgc ggagggatct ccgtggggcg     1860

gtgaacgccg atgattatat aaggacgcgc cgggtgtggc acagctagtt ccgtcgcagc     1920

cgggatttgg gtcgcggttc ttgtttgtgg atcgctgtga tcgtcacttg gtgagtagcg     1980

ggctgctggg ctggccgggg ctttcgtggc cgccgggccg ctcggtggga cggaagcgtg     2040

tggagagacc gccaagggct gtagtctggg tccgcgagca aggttgccct gaactggggg     2100

ttggggggag cgcagcaaaa tggcggctgt tcccgagtct tgaatggaag acgcttgtga     2160

ggcgggctgt gaggtcgttg aaacaaggtg gggggcatgg tgggcggcaa gaacccaagg     2220

tcttgaggcc ttcgctaatg cgggaaagct cttattcggg tgagatgggc tggggcacca     2280

tctggggacc ctgacgtgaa gtttgtcact gactggagaa ctcggtttgt cgtctgttgc     2340

gggggcggca gttatggcgg tgccgttggg cagtgcaccc gtacctttgg gagcgcgcgc     2400

cctcgtcgtg tcgtgacgtc acccgttctg ttggcttata atgcagggtg gggccacctg     2460

ccggtaggtg tgcggtaggc ttttctccgt cgcaggacgc agggttcggg cctagggtag     2520

gctctcctga atcgacaggc gccggacctc tggtgagggg agggataagt gaggcgtcag     2580

tttctttggt cggttttatg tacctatctt cttaagtagc tgaagctccg gttttgaact     2640

atgcgctcgg ggttggcgag tgtgttttgt gaagtttttt aggcaccttt tgaaatgtaa     2700

tcatttgggt caatatgtaa ttttcagtgt tagactagta aattgtccgc taaattctgg     2760

ccgtttttgg cttttttgtt agacgtgttg acaattaatc atcggcatag tatatcggca     2820

tagtataata cgacaaggtg aggaactaaa ccatgggatc ggccattgaa caagatggat     2880

tgcacgcagg ttctccggcc gcttgggtgg agaggctatt cggctatgac tgggcacaac     2940

agacaatcgg ctgctctgat gccgccgtgt tccggctgtc agcgcagggg cgcccggttc     3000

tttttgtcaa gaccgacctg tccggtgccc tgaatgaact gcaggacgag gcagcgcggc     3060

tatcgtggct ggccacgacg ggcgttcctt gcgcagctgt gctcgacgtt gtcactgaag     3120

cgggaaggga ctggctgcta ttgggcgaag tgccggggca ggatctcctg tcatctcacc     3180

ttgctcctgc cgagaaagta tccatcatgg ctgatgcaat gcggcggctg catacgcttg     3240

atccggctac ctgcccattc gaccaccaag cgaaacatcg catcgagcga gcacgtactc     3300

ggatggaagc cggtcttgtc gatcaggatg atctggacga agagcatcag gggctcgcgc     3360

cagccgaact gttcgccagg ctcaaggcgc gcatgcccga cggcgatgat ctcgtcgtga     3420

cccatggcga tgcctgcttg ccgaatatca tggtggaaaa tggccgcttt tctggattca     3480

tcgactgtgg ccggctgggt gtggcggacc gctatcagga catagcgttg gctacccgtg     3540

atattgctga agagcttggc ggcgaatggg ctgaccgctt cctcgtgctt tacggtatcg     3600

ccgctcccga ttcgcagcgc atcgccttct atcgccttct tgacgagttc ttctgagggg     3660

atccgctgta agtctgcaga aattgatgat ctattaaaca ataaagatgt ccactaaaat     3720

ggaagttttt cctgtcatac tttgttaaga agggtgagaa cagagtacct acattttgaa     3780

tggaaggatt ggagctacgg gggtgggggt ggggtgggat tagataaatg cctgctcttt     3840

actgaaggct ctttactatt gctttatgat aatgtttcat agttggatat cataatttaa     3900

acaagcaaaa ccaaattaag ggccagctca ttcctcccac tcatgatcta tagatctata     3960

gatctctcgt gggatcattg tttttctctt gattcccact ttgtggttct aagtactgtg     4020

gtttccaaat gtgtcagttt catagcctga agaacgagat cagcagcctc tgttccacat     4080

acacttcatt ctcagtattg ttttgccaag ttctaattcc atcagacctc gacctgcagc     4140

ccctagataa cttcgtataa tgtatgctat acgaagttat                           4180


<210>  7
<211>  1566
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  8028 insert nucleic acid with lox site after excision of neo and 
       without homology arms

<400>  7
gggtctagca agagcaggtg tgggtttagg aggtgtgtgt ttttgttttt cccaccctct       60

ctccccacta cttgctctca cagtactcgc tgagggtgaa caagaaaaga cctgataaag      120

attaaccaga agaaaacaag gagggaaaca accgcagcct gtagcaagct ctggaactca      180

ggagtcgcgc gctatgcgat cgccgtctcg gggccggggc cggggccggg gccggggccg      240

gggccggggc cggggccggg gccggggccg gggccggggc cggggccggg gccggggccg      300

gggccggggc cggggccggg gccggggccg gggccggggc cggggccggg gccggggccg      360

gggccggggc cggggccggg gccggggccg gggccggggc cggggccggg gccggggccg      420

gggccggggc cggggccggg gccggggccg gggccggggc cggggccggg gccggggccg      480

gggccggggc cggggccggg gccggggccg gggccggggc cggggccggg gccggggccg      540

gggccggggc cggggccggg gccggggccg gggccggggc cggggccggg gccggggccg      600

gggccggggc cggggccggg gccggggccg gggccggggc cggggccggg gccggggccg      660

gggccggggc cggggccggg gccggggccg gggccggggc cggggccggg gccggggccg      720

gggccggggc cggggccggg gccggggccg gggccggggc cgagaccctc gagggccggc      780

cgctagcgcg atcgcggggc gtggtcgggg cgggcccggg ggcgggcccg gggcggggct      840

gcggttgcgg tgcctgcgcc cgcggcggcg gaggcgcagg cggtggcgag tgggtgagtg      900

aggaggcggc atcctggcgg gtggctgttt ggggttcggc tgccgggaag aggcgcgggt      960

agaagcgggg gctctcctca gagctcgacg catttttact ttccctctca tttctctgac     1020

cgaagctggg tgtcgggctt tcgcctctag cgactggtgg aattgcctgc atccgggccc     1080

cgggcttccc ggcggcggcg gcggcggcgg cggcgcaggg acaagggatg gggatctggc     1140

ctcttccttg ctttcccgcc ctcagtaccc gagctgtctc cttcccgggg acccgctggg     1200

agcgctgccg ctgcgggctc gagaaaaggg agcctcgggt actgagaggc ctcgcctggg     1260

ggaaggccgg agggtgggcg gcgcgcggct tctgcggacc aagtcggggt tcgctaggaa     1320

cccgagacgg tccctgccgg cgaggagatc atgcgggatg agatgggggt gtggagacgc     1380

ctgcacaatt tcagcccaag cttctagaga gtggtgatga cttgcatatg agggcagcaa     1440

tgcaagtcgg tgtgctcccc attctgtggg acatgacctg gttgcttcac agctccgaga     1500

tgacacagac ttgcttaaag gaagtgactc gagataactt cgtataatgt atgctatacg     1560

aagtta                                                                1566


<210>  8
<211>  3821
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  8026 targeting nucleic acid with homology arms and neo cassette

<400>  8
gaaccgcggc gcgtcaagca gagacgagtt ccgcccacgt gaaagatggc gtttgtagtg       60

acagccatcc caattgccct ttccttctag gtggaaagtg gggtctagca agagcaggtg      120

tgggtttagg aggtgtgtgt ttttgttttt cccaccctct ctccccacta cttgctctca      180

cagtactcgc tgagggtgaa caagaaaaga cctgataaag attaaccaga agaaaacaag      240

gagggaaaca accgcagcct gtagcaagct ctggaactca ggagtcgcgc gctatgcgat      300

cgcggggccg gggccggggc cgcgatcgcg gggcgtggtc ggggcgggcc cgggggcggg      360

cccggggcgg ggctgcggtt gcggtgcctg cgcccgcggc ggcggaggcg caggcggtgg      420

cgagtgggtg agtgaggagg cggcatcctg gcgggtggct gtttggggtt cggctgccgg      480

gaagaggcgc gggtagaagc gggggctctc ctcagagctc gacgcatttt tactttccct      540

ctcatttctc tgaccgaagc tgggtgtcgg gctttcgcct ctagcgactg gtggaattgc      600

ctgcatccgg gccccgggct tcccggcggc ggcggcggcg gcggcggcgc agggacaagg      660

gatggggatc tggcctcttc cttgctttcc cgccctcagt acccgagctg tctccttccc      720

ggggacccgc tgggagcgct gccgctgcgg gctcgagaaa agggagcctc gggtactgag      780

aggcctcgcc tgggggaagg ccggagggtg ggcggcgcgc ggcttctgcg gaccaagtcg      840

gggttcgcta ggaacccgag acggtccctg ccggcgagga gatcatgcgg gatgagatgg      900

gggtgtggag acgcctgcac aatttcagcc caagcttcta gagagtggtg atgacttgca      960

tatgagggca gcaatgcaag tcggtgtgct ccccattctg tgggacatga cctggttgct     1020

tcacagctcc gagatgacac agacttgctt aaaggaagtg actcgagata acttcgtata     1080

atgtatgcta tacgaagtta tatgcatggc ctccgcgccg ggttttggcg cctcccgcgg     1140

gcgcccccct cctcacggcg agcgctgcca cgtcagacga agggcgcagc gagcgtcctg     1200

atccttccgc ccggacgctc aggacagcgg cccgctgctc ataagactcg gccttagaac     1260

cccagtatca gcagaaggac attttaggac gggacttggg tgactctagg gcactggttt     1320

tctttccaga gagcggaaca ggcgaggaaa agtagtccct tctcggcgat tctgcggagg     1380

gatctccgtg gggcggtgaa cgccgatgat tatataagga cgcgccgggt gtggcacagc     1440

tagttccgtc gcagccggga tttgggtcgc ggttcttgtt tgtggatcgc tgtgatcgtc     1500

acttggtgag tagcgggctg ctgggctggc cggggctttc gtggccgccg ggccgctcgg     1560

tgggacggaa gcgtgtggag agaccgccaa gggctgtagt ctgggtccgc gagcaaggtt     1620

gccctgaact gggggttggg gggagcgcag caaaatggcg gctgttcccg agtcttgaat     1680

ggaagacgct tgtgaggcgg gctgtgaggt cgttgaaaca aggtgggggg catggtgggc     1740

ggcaagaacc caaggtcttg aggccttcgc taatgcggga aagctcttat tcgggtgaga     1800

tgggctgggg caccatctgg ggaccctgac gtgaagtttg tcactgactg gagaactcgg     1860

tttgtcgtct gttgcggggg cggcagttat ggcggtgccg ttgggcagtg cacccgtacc     1920

tttgggagcg cgcgccctcg tcgtgtcgtg acgtcacccg ttctgttggc ttataatgca     1980

gggtggggcc acctgccggt aggtgtgcgg taggcttttc tccgtcgcag gacgcagggt     2040

tcgggcctag ggtaggctct cctgaatcga caggcgccgg acctctggtg aggggaggga     2100

taagtgaggc gtcagtttct ttggtcggtt ttatgtacct atcttcttaa gtagctgaag     2160

ctccggtttt gaactatgcg ctcggggttg gcgagtgtgt tttgtgaagt tttttaggca     2220

ccttttgaaa tgtaatcatt tgggtcaata tgtaattttc agtgttagac tagtaaattg     2280

tccgctaaat tctggccgtt tttggctttt ttgttagacg tgttgacaat taatcatcgg     2340

catagtatat cggcatagta taatacgaca aggtgaggaa ctaaaccatg ggatcggcca     2400

ttgaacaaga tggattgcac gcaggttctc cggccgcttg ggtggagagg ctattcggct     2460

atgactgggc acaacagaca atcggctgct ctgatgccgc cgtgttccgg ctgtcagcgc     2520

aggggcgccc ggttcttttt gtcaagaccg acctgtccgg tgccctgaat gaactgcagg     2580

acgaggcagc gcggctatcg tggctggcca cgacgggcgt tccttgcgca gctgtgctcg     2640

acgttgtcac tgaagcggga agggactggc tgctattggg cgaagtgccg gggcaggatc     2700

tcctgtcatc tcaccttgct cctgccgaga aagtatccat catggctgat gcaatgcggc     2760

ggctgcatac gcttgatccg gctacctgcc cattcgacca ccaagcgaaa catcgcatcg     2820

agcgagcacg tactcggatg gaagccggtc ttgtcgatca ggatgatctg gacgaagagc     2880

atcaggggct cgcgccagcc gaactgttcg ccaggctcaa ggcgcgcatg cccgacggcg     2940

atgatctcgt cgtgacccat ggcgatgcct gcttgccgaa tatcatggtg gaaaatggcc     3000

gcttttctgg attcatcgac tgtggccggc tgggtgtggc ggaccgctat caggacatag     3060

cgttggctac ccgtgatatt gctgaagagc ttggcggcga atgggctgac cgcttcctcg     3120

tgctttacgg tatcgccgct cccgattcgc agcgcatcgc cttctatcgc cttcttgacg     3180

agttcttctg aggggatccg ctgtaagtct gcagaaattg atgatctatt aaacaataaa     3240

gatgtccact aaaatggaag tttttcctgt catactttgt taagaagggt gagaacagag     3300

tacctacatt ttgaatggaa ggattggagc tacgggggtg ggggtggggt gggattagat     3360

aaatgcctgc tctttactga aggctcttta ctattgcttt atgataatgt ttcatagttg     3420

gatatcataa tttaaacaag caaaaccaaa ttaagggcca gctcattcct cccactcatg     3480

atctatagat ctatagatct ctcgtgggat cattgttttt ctcttgattc ccactttgtg     3540

gttctaagta ctgtggtttc caaatgtgtc agtttcatag cctgaagaac gagatcagca     3600

gcctctgttc cacatacact tcattctcag tattgttttg ccaagttcta attccatcag     3660

acctcgacct gcagccccta gataacttcg tataatgtat gctatacgaa gttatgctag     3720

cattgtgact tgggcatcac ttgactgatg gtaatcagtt gcagagagag aagtgcactg     3780

attaagtctg tccacacagg gtctgtctgg ccaggagtgc a                         3821


<210>  9
<211>  4387
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  8026 insert nucleic acid with homology arms, hexanucleotide 
       repeat(s) and neo cassette

<400>  9
gaaccgcggc gcgtcaagca gagacgagtt ccgcccacgt gaaagatggc gtttgtagtg       60

acagccatcc caattgccct ttccttctag gtggaaagtg gggtctagca agagcaggtg      120

tgggtttagg aggtgtgtgt ttttgttttt cccaccctct ctccccacta cttgctctca      180

cagtactcgc tgagggtgaa caagaaaaga cctgataaag attaaccaga agaaaacaag      240

gagggaaaca accgcagcct gtagcaagct ctggaactca ggagtcgcgc gctatgcgat      300

cgccgtctcg gggccggggc cggggccggg gccggggccg gggccggggc cggggccggg      360

gccggggccg gggccggggc cggggccggg gccggggccg gggccggggc cggggccggg      420

gccggggccg gggccggggc cggggccggg gccggggccg gggccggggc cggggccggg      480

gccggggccg gggccggggc cggggccggg gccggggccg gggccggggc cggggccggg      540

gccggggccg gggccggggc cggggccggg gccggggccg gggccggggc cggggccggg      600

gccggggccg gggccggggc cggggccggg gccggggccg gggccggggc cggggccggg      660

gccggggccg gggccggggc cggggccggg gccggggccg gggccggggc cggggccggg      720

gccggggccg gggccggggc cggggccggg gccggggccg gggccggggc cggggccggg      780

gccggggccg gggccggggc cggggccggg gccggggccg gggccggggc cggggccggg      840

gccggggccg gggccggggc cgagaccctc gagggccggc cgctagcgcg atcgcggggc      900

gtggtcgggg cgggcccggg ggcgggcccg gggcggggct gcggttgcgg tgcctgcgcc      960

cgcggcggcg gaggcgcagg cggtggcgag tgggtgagtg aggaggcggc atcctggcgg     1020

gtggctgttt ggggttcggc tgccgggaag aggcgcgggt agaagcgggg gctctcctca     1080

gagctcgacg catttttact ttccctctca tttctctgac cgaagctggg tgtcgggctt     1140

tcgcctctag cgactggtgg aattgcctgc atccgggccc cgggcttccc ggcggcggcg     1200

gcggcggcgg cggcgcaggg acaagggatg gggatctggc ctcttccttg ctttcccgcc     1260

ctcagtaccc gagctgtctc cttcccgggg acccgctggg agcgctgccg ctgcgggctc     1320

gagaaaaggg agcctcgggt actgagaggc ctcgcctggg ggaaggccgg agggtgggcg     1380

gcgcgcggct tctgcggacc aagtcggggt tcgctaggaa cccgagacgg tccctgccgg     1440

cgaggagatc atgcgggatg agatgggggt gtggagacgc ctgcacaatt tcagcccaag     1500

cttctagaga gtggtgatga cttgcatatg agggcagcaa tgcaagtcgg tgtgctcccc     1560

attctgtggg acatgacctg gttgcttcac agctccgaga tgacacagac ttgcttaaag     1620

gaagtgactc gagataactt cgtataatgt atgctatacg aagttatatg catggcctcc     1680

gcgccgggtt ttggcgcctc ccgcgggcgc ccccctcctc acggcgagcg ctgccacgtc     1740

agacgaaggg cgcagcgagc gtcctgatcc ttccgcccgg acgctcagga cagcggcccg     1800

ctgctcataa gactcggcct tagaacccca gtatcagcag aaggacattt taggacggga     1860

cttgggtgac tctagggcac tggttttctt tccagagagc ggaacaggcg aggaaaagta     1920

gtcccttctc ggcgattctg cggagggatc tccgtggggc ggtgaacgcc gatgattata     1980

taaggacgcg ccgggtgtgg cacagctagt tccgtcgcag ccgggatttg ggtcgcggtt     2040

cttgtttgtg gatcgctgtg atcgtcactt ggtgagtagc gggctgctgg gctggccggg     2100

gctttcgtgg ccgccgggcc gctcggtggg acggaagcgt gtggagagac cgccaagggc     2160

tgtagtctgg gtccgcgagc aaggttgccc tgaactgggg gttgggggga gcgcagcaaa     2220

atggcggctg ttcccgagtc ttgaatggaa gacgcttgtg aggcgggctg tgaggtcgtt     2280

gaaacaaggt ggggggcatg gtgggcggca agaacccaag gtcttgaggc cttcgctaat     2340

gcgggaaagc tcttattcgg gtgagatggg ctggggcacc atctggggac cctgacgtga     2400

agtttgtcac tgactggaga actcggtttg tcgtctgttg cgggggcggc agttatggcg     2460

gtgccgttgg gcagtgcacc cgtacctttg ggagcgcgcg ccctcgtcgt gtcgtgacgt     2520

cacccgttct gttggcttat aatgcagggt ggggccacct gccggtaggt gtgcggtagg     2580

cttttctccg tcgcaggacg cagggttcgg gcctagggta ggctctcctg aatcgacagg     2640

cgccggacct ctggtgaggg gagggataag tgaggcgtca gtttctttgg tcggttttat     2700

gtacctatct tcttaagtag ctgaagctcc ggttttgaac tatgcgctcg gggttggcga     2760

gtgtgttttg tgaagttttt taggcacctt ttgaaatgta atcatttggg tcaatatgta     2820

attttcagtg ttagactagt aaattgtccg ctaaattctg gccgtttttg gcttttttgt     2880

tagacgtgtt gacaattaat catcggcata gtatatcggc atagtataat acgacaaggt     2940

gaggaactaa accatgggat cggccattga acaagatgga ttgcacgcag gttctccggc     3000

cgcttgggtg gagaggctat tcggctatga ctgggcacaa cagacaatcg gctgctctga     3060

tgccgccgtg ttccggctgt cagcgcaggg gcgcccggtt ctttttgtca agaccgacct     3120

gtccggtgcc ctgaatgaac tgcaggacga ggcagcgcgg ctatcgtggc tggccacgac     3180

gggcgttcct tgcgcagctg tgctcgacgt tgtcactgaa gcgggaaggg actggctgct     3240

attgggcgaa gtgccggggc aggatctcct gtcatctcac cttgctcctg ccgagaaagt     3300

atccatcatg gctgatgcaa tgcggcggct gcatacgctt gatccggcta cctgcccatt     3360

cgaccaccaa gcgaaacatc gcatcgagcg agcacgtact cggatggaag ccggtcttgt     3420

cgatcaggat gatctggacg aagagcatca ggggctcgcg ccagccgaac tgttcgccag     3480

gctcaaggcg cgcatgcccg acggcgatga tctcgtcgtg acccatggcg atgcctgctt     3540

gccgaatatc atggtggaaa atggccgctt ttctggattc atcgactgtg gccggctggg     3600

tgtggcggac cgctatcagg acatagcgtt ggctacccgt gatattgctg aagagcttgg     3660

cggcgaatgg gctgaccgct tcctcgtgct ttacggtatc gccgctcccg attcgcagcg     3720

catcgccttc tatcgccttc ttgacgagtt cttctgaggg gatccgctgt aagtctgcag     3780

aaattgatga tctattaaac aataaagatg tccactaaaa tggaagtttt tcctgtcata     3840

ctttgttaag aagggtgaga acagagtacc tacattttga atggaaggat tggagctacg     3900

ggggtggggg tggggtggga ttagataaat gcctgctctt tactgaaggc tctttactat     3960

tgctttatga taatgtttca tagttggata tcataattta aacaagcaaa accaaattaa     4020

gggccagctc attcctccca ctcatgatct atagatctat agatctctcg tgggatcatt     4080

gtttttctct tgattcccac tttgtggttc taagtactgt ggtttccaaa tgtgtcagtt     4140

tcatagcctg aagaacgaga tcagcagcct ctgttccaca tacacttcat tctcagtatt     4200

gttttgccaa gttctaattc catcagacct cgacctgcag cccctagata acttcgtata     4260

atgtatgcta tacgaagtta tgctagcatt gtgacttggg catcacttga ctgatggtaa     4320

tcagttgcag agagagaagt gcactgatta agtctgtcca cacagggtct gtctggccag     4380

gagtgca                                                               4387


<210>  10
<211>  1957
<212>  DNA
<213>  Homo sapiens

<400>  10
acgtaaccta cggtgtcccg ctaggaaaga gaggtgcgtc aaacagcgac aagttccgcc       60

cacgtaaaag atgacgcttg atatctccgg agcatttgga taatgtgaca gttggaatgc      120

agtgatgtcg actctttgcc caccgccatc tccagctgtt gccaagacag agattgcttt      180

aagtggcaaa tcacctttat tagcagctac ttttgcttac tgggacaata ttcttggtcc      240

tagagtaagg cacatttggg ctccaaagac agaacaggta cttctcagtg atggagaaat      300

aacttttctt gccaaccaca ctctaaatgg agaaatcctt cgaaatgcag agagtggtgc      360

tatagatgta aagttttttg tcttgtctga aaagggagtg attattgttt cattaatctt      420

tgatggaaac tggaatgggg atcgcagcac atatggacta tcaattatac ttccacagac      480

agaacttagt ttctacctcc cacttcatag agtgtgtgtt gatagattaa cacatataat      540

ccggaaagga agaatatgga tgcataagga aagacaagaa aatgtccaga agattatctt      600

agaaggcaca gagagaatgg aagatcaggg tcagagtatt attccaatgc ttactggaga      660

agtgattcct gtaatggaac tgctttcatc tatgaaatca cacagtgttc ctgaagaaat      720

agatatagct gatacagtac tcaatgatga tgatattggt gacagctgtc atgaaggctt      780

tcttctcaag taagaatttt tcttttcata aaagctggat gaagcagata ccatcttatg      840

ctcacctatg acaagatttg gaagaaagaa aataacagac tgtctactta gattgttcta      900

gggacattac gtatttgaac tgttgcttaa atttgtgtta tttttcactc attatatttc      960

tatatatatt tggtgttatt ccatttgcta tttaaagaaa ccgagtttcc atcccagaca     1020

agaaatcatg gccccttgct tgattctggt ttcttgtttt acttctcatt aaagctaaca     1080

gaatcctttc atattaagtt gtactgtaga tgaacttaag ttatttaggc gtagaacaaa     1140

attattcata tttatactga tctttttcca tccagcagtg gagtttagta cttaagagtt     1200

tgtgccctta aaccagactc cctggattaa tgctgtgtac ccgtgggcaa ggtgcctgaa     1260

ttctctatac acctatttcc tcatctgtaa aatggcaata atagtaatag tacctaatgt     1320

gtagggttgt tataagcatt gagtaagata aataatataa agcacttaga acagtgcctg     1380

gaacataaaa acacttaata atagctcata gctaacattt cctatttaca tttcttctag     1440

aaatagccag tatttgttga gtgcctacat gttagttcct ttactagttg ctttacatgt     1500

attatcttat attctgtttt aaagtttctt cacagttaca gattttcatg aaattttact     1560

tttaataaaa gagaagtaaa agtataaagt attcactttt atgttcacag tcttttcctt     1620

taggctcatg atggagtatc agaggcatga gtgtgtttaa cctaagagcc ttaatggctt     1680

gaatcagaag cactttagtc ctgtatctgt tcagtgtcag cctttcatac atcattttaa     1740

atcccatttg actttaagta agtcacttaa tctctctaca tgtcaatttc ttcagctata     1800

aaatgatggt atttcaataa ataaatacat taattaaatg atattatact gactaattgg     1860

gctgttttaa ggctcaataa gaaaatttct gtgaaaggtc tctagaaaat gtaggttcct     1920

atacaaataa aagataacat tgtgcttata aaaaaaa                              1957


<210>  11
<211>  222
<212>  PRT
<213>  Homo sapiens

<400>  11

Met Ser Thr Leu Cys Pro Pro Pro Ser Pro Ala Val Ala Lys Thr Glu 
1               5                   10                  15      


Ile Ala Leu Ser Gly Lys Ser Pro Leu Leu Ala Ala Thr Phe Ala Tyr 
            20                  25                  30          


Trp Asp Asn Ile Leu Gly Pro Arg Val Arg His Ile Trp Ala Pro Lys 
        35                  40                  45              


Thr Glu Gln Val Leu Leu Ser Asp Gly Glu Ile Thr Phe Leu Ala Asn 
    50                  55                  60                  


His Thr Leu Asn Gly Glu Ile Leu Arg Asn Ala Glu Ser Gly Ala Ile 
65                  70                  75                  80  


Asp Val Lys Phe Phe Val Leu Ser Glu Lys Gly Val Ile Ile Val Ser 
                85                  90                  95      


Leu Ile Phe Asp Gly Asn Trp Asn Gly Asp Arg Ser Thr Tyr Gly Leu 
            100                 105                 110         


Ser Ile Ile Leu Pro Gln Thr Glu Leu Ser Phe Tyr Leu Pro Leu His 
        115                 120                 125             


Arg Val Cys Val Asp Arg Leu Thr His Ile Ile Arg Lys Gly Arg Ile 
    130                 135                 140                 


Trp Met His Lys Glu Arg Gln Glu Asn Val Gln Lys Ile Ile Leu Glu 
145                 150                 155                 160 


Gly Thr Glu Arg Met Glu Asp Gln Gly Gln Ser Ile Ile Pro Met Leu 
                165                 170                 175     


Thr Gly Glu Val Ile Pro Val Met Glu Leu Leu Ser Ser Met Lys Ser 
            180                 185                 190         


His Ser Val Pro Glu Glu Ile Asp Ile Ala Asp Thr Val Leu Asn Asp 
        195                 200                 205             


Asp Asp Ile Gly Asp Ser Cys His Glu Gly Phe Leu Leu Lys 
    210                 215                 220         


<210>  12
<211>  3261
<212>  DNA
<213>  Homo sapiens

<400>  12
gggcggggct gcggttgcgg tgcctgcgcc cgcggcggcg gaggcgcagg cggtggcgag       60

tggatatctc cggagcattt ggataatgtg acagttggaa tgcagtgatg tcgactcttt      120

gcccaccgcc atctccagct gttgccaaga cagagattgc tttaagtggc aaatcacctt      180

tattagcagc tacttttgct tactgggaca atattcttgg tcctagagta aggcacattt      240

gggctccaaa gacagaacag gtacttctca gtgatggaga aataactttt cttgccaacc      300

acactctaaa tggagaaatc cttcgaaatg cagagagtgg tgctatagat gtaaagtttt      360

ttgtcttgtc tgaaaaggga gtgattattg tttcattaat ctttgatgga aactggaatg      420

gggatcgcag cacatatgga ctatcaatta tacttccaca gacagaactt agtttctacc      480

tcccacttca tagagtgtgt gttgatagat taacacatat aatccggaaa ggaagaatat      540

ggatgcataa ggaaagacaa gaaaatgtcc agaagattat cttagaaggc acagagagaa      600

tggaagatca gggtcagagt attattccaa tgcttactgg agaagtgatt cctgtaatgg      660

aactgctttc atctatgaaa tcacacagtg ttcctgaaga aatagatata gctgatacag      720

tactcaatga tgatgatatt ggtgacagct gtcatgaagg ctttcttctc aatgccatca      780

gctcacactt gcaaacctgt ggctgttccg ttgtagtagg tagcagtgca gagaaagtaa      840

ataagatagt cagaacatta tgcctttttc tgactccagc agagagaaaa tgctccaggt      900

tatgtgaagc agaatcatca tttaaatatg agtcagggct ctttgtacaa ggcctgctaa      960

aggattcaac tggaagcttt gtgctgcctt tccggcaagt catgtatgct ccatatccca     1020

ccacacacat agatgtggat gtcaatactg tgaagcagat gccaccctgt catgaacata     1080

tttataatca gcgtagatac atgagatccg agctgacagc cttctggaga gccacttcag     1140

aagaagacat ggctcaggat acgatcatct acactgacga aagctttact cctgatttga     1200

atatttttca agatgtctta cacagagaca ctctagtgaa agccttcctg gatcaggtct     1260

ttcagctgaa acctggctta tctctcagaa gtactttcct tgcacagttt ctacttgtcc     1320

ttcacagaaa agccttgaca ctaataaaat atatagaaga cgatacgcag aagggaaaaa     1380

agccctttaa atctcttcgg aacctgaaga tagaccttga tttaacagca gagggcgatc     1440

ttaacataat aatggctctg gctgagaaaa ttaaaccagg cctacactct tttatctttg     1500

gaagaccttt ctacactagt gtgcaagaac gagatgttct aatgactttt taaatgtgta     1560

acttaataag cctattccat cacaatcatg atcgctggta aagtagctca gtggtgtggg     1620

gaaacgttcc cctggatcat actccagaat tctgctctca gcaattgcag ttaagtaagt     1680

tacactacag ttctcacaag agcctgtgag gggatgtcag gtgcatcatt acattgggtg     1740

tctcttttcc tagatttatg cttttgggat acagacctat gtttacaata taataaatat     1800

tattgctatc ttttaaagat ataataatag gatgtaaact tgaccacaac tactgttttt     1860

ttgaaataca tgattcatgg tttacatgtg tcaaggtgaa atctgagttg gcttttacag     1920

atagttgact ttctatcttt tggcattctt tggtgtgtag aattactgta atacttctgc     1980

aatcaactga aaactagagc ctttaaatga tttcaattcc acagaaagaa agtgagcttg     2040

aacataggat gagctttaga aagaaaattg atcaagcaga tgtttaattg gaattgatta     2100

ttagatccta ctttgtggat ttagtccctg ggattcagtc tgtagaaatg tctaatagtt     2160

ctctatagtc cttgttcctg gtgaaccaca gttagggtgt tttgtttatt ttattgttct     2220

tgctattgtt gatattctat gtagttgagc tctgtaaaag gaaattgtat tttatgtttt     2280

agtaattgtt gccaactttt taaattaatt ttcattattt ttgagccaaa ttgaaatgtg     2340

cacctcctgt gccttttttc tccttagaaa atctaattac ttggaacaag ttcagatttc     2400

actggtcagt cattttcatc ttgttttctt cttgctaagt cttaccatgt acctgctttg     2460

gcaatcattg caactctgag attataaaat gccttagaga atatactaac taataagatc     2520

tttttttcag aaacagaaaa tagttccttg agtacttcct tcttgcattt ctgcctatgt     2580

ttttgaagtt gttgctgttt gcctgcaata ggctataagg aatagcagga gaaattttac     2640

tgaagtgctg ttttcctagg tgctactttg gcagagctaa gttatctttt gttttcttaa     2700

tgcgtttgga ccattttgct ggctataaaa taactgatta atataattct aacacaatgt     2760

tgacattgta gttacacaaa cacaaataaa tattttattt aaaattctgg aagtaatata     2820

aaagggaaaa tatatttata agaaagggat aaaggtaata gagcccttct gccccccacc     2880

caccaaattt acacaacaaa atgacatgtt cgaatgtgaa aggtcataat agctttccca     2940

tcatgaatca gaaagatgtg gacagcttga tgttttagac aaccactgaa ctagatgact     3000

gttgtactgt agctcagtca tttaaaaaat atataaatac taccttgtag tgtcccatac     3060

tgtgtttttt acatggtaga ttcttattta agtgctaact ggttattttc tttggctggt     3120

ttattgtact gttatacaga atgtaagttg tacagtgaaa taagttatta aagcatgtgt     3180

aaacattgtt atatatcttt tctcctaaat ggagaatttt gaataaaata tatttgaaat     3240

tttaaaaaaa aaaaaaaaaa a                                               3261


<210>  13
<211>  481
<212>  PRT
<213>  Homo sapiens

<400>  13

Met Ser Thr Leu Cys Pro Pro Pro Ser Pro Ala Val Ala Lys Thr Glu 
1               5                   10                  15      


Ile Ala Leu Ser Gly Lys Ser Pro Leu Leu Ala Ala Thr Phe Ala Tyr 
            20                  25                  30          


Trp Asp Asn Ile Leu Gly Pro Arg Val Arg His Ile Trp Ala Pro Lys 
        35                  40                  45              


Thr Glu Gln Val Leu Leu Ser Asp Gly Glu Ile Thr Phe Leu Ala Asn 
    50                  55                  60                  


His Thr Leu Asn Gly Glu Ile Leu Arg Asn Ala Glu Ser Gly Ala Ile 
65                  70                  75                  80  


Asp Val Lys Phe Phe Val Leu Ser Glu Lys Gly Val Ile Ile Val Ser 
                85                  90                  95      


Leu Ile Phe Asp Gly Asn Trp Asn Gly Asp Arg Ser Thr Tyr Gly Leu 
            100                 105                 110         


Ser Ile Ile Leu Pro Gln Thr Glu Leu Ser Phe Tyr Leu Pro Leu His 
        115                 120                 125             


Arg Val Cys Val Asp Arg Leu Thr His Ile Ile Arg Lys Gly Arg Ile 
    130                 135                 140                 


Trp Met His Lys Glu Arg Gln Glu Asn Val Gln Lys Ile Ile Leu Glu 
145                 150                 155                 160 


Gly Thr Glu Arg Met Glu Asp Gln Gly Gln Ser Ile Ile Pro Met Leu 
                165                 170                 175     


Thr Gly Glu Val Ile Pro Val Met Glu Leu Leu Ser Ser Met Lys Ser 
            180                 185                 190         


His Ser Val Pro Glu Glu Ile Asp Ile Ala Asp Thr Val Leu Asn Asp 
        195                 200                 205             


Asp Asp Ile Gly Asp Ser Cys His Glu Gly Phe Leu Leu Asn Ala Ile 
    210                 215                 220                 


Ser Ser His Leu Gln Thr Cys Gly Cys Ser Val Val Val Gly Ser Ser 
225                 230                 235                 240 


Ala Glu Lys Val Asn Lys Ile Val Arg Thr Leu Cys Leu Phe Leu Thr 
                245                 250                 255     


Pro Ala Glu Arg Lys Cys Ser Arg Leu Cys Glu Ala Glu Ser Ser Phe 
            260                 265                 270         


Lys Tyr Glu Ser Gly Leu Phe Val Gln Gly Leu Leu Lys Asp Ser Thr 
        275                 280                 285             


Gly Ser Phe Val Leu Pro Phe Arg Gln Val Met Tyr Ala Pro Tyr Pro 
    290                 295                 300                 


Thr Thr His Ile Asp Val Asp Val Asn Thr Val Lys Gln Met Pro Pro 
305                 310                 315                 320 


Cys His Glu His Ile Tyr Asn Gln Arg Arg Tyr Met Arg Ser Glu Leu 
                325                 330                 335     


Thr Ala Phe Trp Arg Ala Thr Ser Glu Glu Asp Met Ala Gln Asp Thr 
            340                 345                 350         


Ile Ile Tyr Thr Asp Glu Ser Phe Thr Pro Asp Leu Asn Ile Phe Gln 
        355                 360                 365             


Asp Val Leu His Arg Asp Thr Leu Val Lys Ala Phe Leu Asp Gln Val 
    370                 375                 380                 


Phe Gln Leu Lys Pro Gly Leu Ser Leu Arg Ser Thr Phe Leu Ala Gln 
385                 390                 395                 400 


Phe Leu Leu Val Leu His Arg Lys Ala Leu Thr Leu Ile Lys Tyr Ile 
                405                 410                 415     


Glu Asp Asp Thr Gln Lys Gly Lys Lys Pro Phe Lys Ser Leu Arg Asn 
            420                 425                 430         


Leu Lys Ile Asp Leu Asp Leu Thr Ala Glu Gly Asp Leu Asn Ile Ile 
        435                 440                 445             


Met Ala Leu Ala Glu Lys Ile Lys Pro Gly Leu His Ser Phe Ile Phe 
    450                 455                 460                 


Gly Arg Pro Phe Tyr Thr Ser Val Gln Glu Arg Asp Val Leu Met Thr 
465                 470                 475                 480 


Phe 
    


<210>  14
<211>  3356
<212>  DNA
<213>  Homo sapiens

<400>  14
acgtaaccta cggtgtcccg ctaggaaaga gaggtgcgtc aaacagcgac aagttccgcc       60

cacgtaaaag atgacgcttg gtgtgtcagc cgtccctgct gcccggttgc ttctcttttg      120

ggggcggggt ctagcaagag caggtgtggg tttaggagat atctccggag catttggata      180

atgtgacagt tggaatgcag tgatgtcgac tctttgccca ccgccatctc cagctgttgc      240

caagacagag attgctttaa gtggcaaatc acctttatta gcagctactt ttgcttactg      300

ggacaatatt cttggtccta gagtaaggca catttgggct ccaaagacag aacaggtact      360

tctcagtgat ggagaaataa cttttcttgc caaccacact ctaaatggag aaatccttcg      420

aaatgcagag agtggtgcta tagatgtaaa gttttttgtc ttgtctgaaa agggagtgat      480

tattgtttca ttaatctttg atggaaactg gaatggggat cgcagcacat atggactatc      540

aattatactt ccacagacag aacttagttt ctacctccca cttcatagag tgtgtgttga      600

tagattaaca catataatcc ggaaaggaag aatatggatg cataaggaaa gacaagaaaa      660

tgtccagaag attatcttag aaggcacaga gagaatggaa gatcagggtc agagtattat      720

tccaatgctt actggagaag tgattcctgt aatggaactg ctttcatcta tgaaatcaca      780

cagtgttcct gaagaaatag atatagctga tacagtactc aatgatgatg atattggtga      840

cagctgtcat gaaggctttc ttctcaatgc catcagctca cacttgcaaa cctgtggctg      900

ttccgttgta gtaggtagca gtgcagagaa agtaaataag atagtcagaa cattatgcct      960

ttttctgact ccagcagaga gaaaatgctc caggttatgt gaagcagaat catcatttaa     1020

atatgagtca gggctctttg tacaaggcct gctaaaggat tcaactggaa gctttgtgct     1080

gcctttccgg caagtcatgt atgctccata tcccaccaca cacatagatg tggatgtcaa     1140

tactgtgaag cagatgccac cctgtcatga acatatttat aatcagcgta gatacatgag     1200

atccgagctg acagccttct ggagagccac ttcagaagaa gacatggctc aggatacgat     1260

catctacact gacgaaagct ttactcctga tttgaatatt tttcaagatg tcttacacag     1320

agacactcta gtgaaagcct tcctggatca ggtctttcag ctgaaacctg gcttatctct     1380

cagaagtact ttccttgcac agtttctact tgtccttcac agaaaagcct tgacactaat     1440

aaaatatata gaagacgata cgcagaaggg aaaaaagccc tttaaatctc ttcggaacct     1500

gaagatagac cttgatttaa cagcagaggg cgatcttaac ataataatgg ctctggctga     1560

gaaaattaaa ccaggcctac actcttttat ctttggaaga cctttctaca ctagtgtgca     1620

agaacgagat gttctaatga ctttttaaat gtgtaactta ataagcctat tccatcacaa     1680

tcatgatcgc tggtaaagta gctcagtggt gtggggaaac gttcccctgg atcatactcc     1740

agaattctgc tctcagcaat tgcagttaag taagttacac tacagttctc acaagagcct     1800

gtgaggggat gtcaggtgca tcattacatt gggtgtctct tttcctagat ttatgctttt     1860

gggatacaga cctatgttta caatataata aatattattg ctatctttta aagatataat     1920

aataggatgt aaacttgacc acaactactg tttttttgaa atacatgatt catggtttac     1980

atgtgtcaag gtgaaatctg agttggcttt tacagatagt tgactttcta tcttttggca     2040

ttctttggtg tgtagaatta ctgtaatact tctgcaatca actgaaaact agagccttta     2100

aatgatttca attccacaga aagaaagtga gcttgaacat aggatgagct ttagaaagaa     2160

aattgatcaa gcagatgttt aattggaatt gattattaga tcctactttg tggatttagt     2220

ccctgggatt cagtctgtag aaatgtctaa tagttctcta tagtccttgt tcctggtgaa     2280

ccacagttag ggtgttttgt ttattttatt gttcttgcta ttgttgatat tctatgtagt     2340

tgagctctgt aaaaggaaat tgtattttat gttttagtaa ttgttgccaa ctttttaaat     2400

taattttcat tatttttgag ccaaattgaa atgtgcacct cctgtgcctt ttttctcctt     2460

agaaaatcta attacttgga acaagttcag atttcactgg tcagtcattt tcatcttgtt     2520

ttcttcttgc taagtcttac catgtacctg ctttggcaat cattgcaact ctgagattat     2580

aaaatgcctt agagaatata ctaactaata agatcttttt ttcagaaaca gaaaatagtt     2640

ccttgagtac ttccttcttg catttctgcc tatgtttttg aagttgttgc tgtttgcctg     2700

caataggcta taaggaatag caggagaaat tttactgaag tgctgttttc ctaggtgcta     2760

ctttggcaga gctaagttat cttttgtttt cttaatgcgt ttggaccatt ttgctggcta     2820

taaaataact gattaatata attctaacac aatgttgaca ttgtagttac acaaacacaa     2880

ataaatattt tatttaaaat tctggaagta atataaaagg gaaaatatat ttataagaaa     2940

gggataaagg taatagagcc cttctgcccc ccacccacca aatttacaca acaaaatgac     3000

atgttcgaat gtgaaaggtc ataatagctt tcccatcatg aatcagaaag atgtggacag     3060

cttgatgttt tagacaacca ctgaactaga tgactgttgt actgtagctc agtcatttaa     3120

aaaatatata aatactacct tgtagtgtcc catactgtgt tttttacatg gtagattctt     3180

atttaagtgc taactggtta ttttctttgg ctggtttatt gtactgttat acagaatgta     3240

agttgtacag tgaaataagt tattaaagca tgtgtaaaca ttgttatata tcttttctcc     3300

taaatggaga attttgaata aaatatattt gaaattttaa aaaaaaaaaa aaaaaa         3356


<210>  15
<211>  481
<212>  PRT
<213>  Homo sapiens

<400>  15

Met Ser Thr Leu Cys Pro Pro Pro Ser Pro Ala Val Ala Lys Thr Glu 
1               5                   10                  15      


Ile Ala Leu Ser Gly Lys Ser Pro Leu Leu Ala Ala Thr Phe Ala Tyr 
            20                  25                  30          


Trp Asp Asn Ile Leu Gly Pro Arg Val Arg His Ile Trp Ala Pro Lys 
        35                  40                  45              


Thr Glu Gln Val Leu Leu Ser Asp Gly Glu Ile Thr Phe Leu Ala Asn 
    50                  55                  60                  


His Thr Leu Asn Gly Glu Ile Leu Arg Asn Ala Glu Ser Gly Ala Ile 
65                  70                  75                  80  


Asp Val Lys Phe Phe Val Leu Ser Glu Lys Gly Val Ile Ile Val Ser 
                85                  90                  95      


Leu Ile Phe Asp Gly Asn Trp Asn Gly Asp Arg Ser Thr Tyr Gly Leu 
            100                 105                 110         


Ser Ile Ile Leu Pro Gln Thr Glu Leu Ser Phe Tyr Leu Pro Leu His 
        115                 120                 125             


Arg Val Cys Val Asp Arg Leu Thr His Ile Ile Arg Lys Gly Arg Ile 
    130                 135                 140                 


Trp Met His Lys Glu Arg Gln Glu Asn Val Gln Lys Ile Ile Leu Glu 
145                 150                 155                 160 


Gly Thr Glu Arg Met Glu Asp Gln Gly Gln Ser Ile Ile Pro Met Leu 
                165                 170                 175     


Thr Gly Glu Val Ile Pro Val Met Glu Leu Leu Ser Ser Met Lys Ser 
            180                 185                 190         


His Ser Val Pro Glu Glu Ile Asp Ile Ala Asp Thr Val Leu Asn Asp 
        195                 200                 205             


Asp Asp Ile Gly Asp Ser Cys His Glu Gly Phe Leu Leu Asn Ala Ile 
    210                 215                 220                 


Ser Ser His Leu Gln Thr Cys Gly Cys Ser Val Val Val Gly Ser Ser 
225                 230                 235                 240 


Ala Glu Lys Val Asn Lys Ile Val Arg Thr Leu Cys Leu Phe Leu Thr 
                245                 250                 255     


Pro Ala Glu Arg Lys Cys Ser Arg Leu Cys Glu Ala Glu Ser Ser Phe 
            260                 265                 270         


Lys Tyr Glu Ser Gly Leu Phe Val Gln Gly Leu Leu Lys Asp Ser Thr 
        275                 280                 285             


Gly Ser Phe Val Leu Pro Phe Arg Gln Val Met Tyr Ala Pro Tyr Pro 
    290                 295                 300                 


Thr Thr His Ile Asp Val Asp Val Asn Thr Val Lys Gln Met Pro Pro 
305                 310                 315                 320 


Cys His Glu His Ile Tyr Asn Gln Arg Arg Tyr Met Arg Ser Glu Leu 
                325                 330                 335     


Thr Ala Phe Trp Arg Ala Thr Ser Glu Glu Asp Met Ala Gln Asp Thr 
            340                 345                 350         


Ile Ile Tyr Thr Asp Glu Ser Phe Thr Pro Asp Leu Asn Ile Phe Gln 
        355                 360                 365             


Asp Val Leu His Arg Asp Thr Leu Val Lys Ala Phe Leu Asp Gln Val 
    370                 375                 380                 


Phe Gln Leu Lys Pro Gly Leu Ser Leu Arg Ser Thr Phe Leu Ala Gln 
385                 390                 395                 400 


Phe Leu Leu Val Leu His Arg Lys Ala Leu Thr Leu Ile Lys Tyr Ile 
                405                 410                 415     


Glu Asp Asp Thr Gln Lys Gly Lys Lys Pro Phe Lys Ser Leu Arg Asn 
            420                 425                 430         


Leu Lys Ile Asp Leu Asp Leu Thr Ala Glu Gly Asp Leu Asn Ile Ile 
        435                 440                 445             


Met Ala Leu Ala Glu Lys Ile Lys Pro Gly Leu His Ser Phe Ile Phe 
    450                 455                 460                 


Gly Arg Pro Phe Tyr Thr Ser Val Gln Glu Arg Asp Val Leu Met Thr 
465                 470                 475                 480 


Phe 
    


<210>  16
<211>  3198
<212>  DNA
<213>  Mus musculus

<400>  16
gtgtccgggg cggggcggtc ccggggcggg gcccggagcg ggctgcggtt gcggtccctg       60

cgccggcggt gaaggcgcag cagcggcgag tggctattgc aagcgttcgg ataatgtgag      120

acctggaatg cagtgagacc tgggatgcag ggatgtcgac tatctgcccc ccaccatctc      180

ctgctgttgc caagacagag attgctttaa gtggtgaatc acccttgttg gcggctacct      240

ttgcttactg ggataatatt cttggtccta gagtaaggca tatttgggct ccaaagacag      300

accaagtgct tctcagtgat ggagaaataa cttttcttgc caaccacact ctaaatggag      360

aaattcttcg aaatgcagag agtggggcta tagatgtaaa attttttgtc ttatctgaaa      420

aaggggtaat tattgtttca ttaatcttcg acggaaactg gaatggagat cggagcactt      480

atggactatc aattatactg ccgcagacag agctgagctt ctacctccca cttcacagag      540

tgtgtgttga caggctaaca cacattattc gaaaaggaag aatatggatg cataaggaaa      600

gacaagaaaa tgtccagaaa attgtcttgg aaggcacaga gaggatggaa gatcagggtc      660

agagtatcat tcccatgctt actggggaag tcattcctgt aatggagctg cttgcatcta      720

tgaaatccca cagtgttcct gaagacattg atatagctga tacagtgctc aatgatgatg      780

acattggtga cagctgtcac gaaggctttc ttctcaatgc catcagctca cacctgcaga      840

cctgtggctg ttccgttgta gttggcagca gtgcagagaa agtaaataag atagtaagaa      900

cgctgtgcct ttttctgaca ccagcagaga ggaaatgctc caggctgtgt gaagcagaat      960

cgtcctttaa gtacgaatcg ggactctttg tgcaaggctt gctaaaggat gcaacaggca     1020

gttttgtcct acccttccgg caagttatgt atgccccgta ccccaccacg cacattgatg     1080

tggatgtcaa cactgtcaag cagatgccac cgtgtcatga acatatttat aatcaacgca     1140

gatacatgag gtcagagctg acagccttct ggagggcaac ttcagaagag gacatggcgc     1200

aggacaccat catctacaca gatgagagct tcactcctga tttgaatatt ttccaagatg     1260

tcttacacag agacactcta gtgaaagcct tcctggatca ggtcttccat ttgaagcctg     1320

gcctgtctct caggagtact ttccttgcac agttcctcct cattcttcac agaaaagcct     1380

tgacactaat caagtacatc gaggatgata cgcagaaggg gaaaaagccc tttaagtctc     1440

ttcggaacct gaagatagat cttgatttaa cagcagaggg cgatcttaac ataataatgg     1500

ctctagctga gaaaattaag ccaggcctac actctttcat ctttgggaga cctttctaca     1560

ctagtgtaca agaacgtgat gttctaatga ccttttgacc gtgtggtttg ctgtgtctgt     1620

ctcttcacag tcacacctgc tgttacagtg tctcagcagt gtgtgggcac atccttcctc     1680

ccgagtcctg ctgcaggaca gggtacacta cacttgtcag tagaagtctg tacctgatgt     1740

caggtgcatc gttacagtga atgactcttc ctagaataga tgtactcttt tagggcctta     1800

tgtttacaat tatcctaagt actattgctg tcttttaaag atatgaatga tggaatatac     1860

acttgaccat aactgctgat tggttttttg ttttgttttg tttgttttct tggaaactta     1920

tgattcctgg tttacatgta ccacactgaa accctcgtta gctttacaga taaagtgtga     1980

gttgacttcc tgcccctctg tgttctgtgg tatgtccgat tacttctgcc acagctaaac     2040

attagagcat ttaaagtttg cagttcctca gaaaggaact tagtctgact acagattagt     2100

tcttgagaga agacactgat agggcagagc tgtaggtgaa atcagttgtt agcccttcct     2160

ttatagacgt agtccttcag attcggtctg tacagaaatg ccgaggggtc atgcatgggc     2220

cctgagtatc gtgacctgtg acaagttttt tgttggttta ttgtagttct gtcaaagaaa     2280

gtggcatttg tttttataat tgttgccaac ttttaaggtt aattttcatt atttttgagc     2340

cgaattaaaa tgcgcacctc ctgtgccttt cccaatcttg gaaaatataa tttcttggca     2400

gagggtcaga tttcagggcc cagtcacttt catctgacca ccctttgcac ggctgccgtg     2460

tgcctggctt agattagaag tccttgttaa gtatgtcaga gtacattcgc tgataagatc     2520

tttgaagagc agggaagcgt cttgcctctt tcctttggtt tctgcctgta ctctggtgtt     2580

tcccgtgtca cctgcatcat aggaacagca gagaaatctg acccagtgct atttttctag     2640

gtgctactat ggcaaactca agtggtctgt ttctgttcct gtaacgttcg actatctcgc     2700

tagctgtgaa gtactgatta gtggagttct gtgcaacagc agtgtaggag tatacacaaa     2760

cacaaatatg tgtttctatt taaaactgtg gacttagcat aaaaagggag aatatattta     2820

ttttttacaa aagggataaa aatgggcccc gttcctcacc caccagattt agcgagaaaa     2880

agctttctat tctgaaaggt cacggtggct ttggcattac aaatcagaac aacacacact     2940

gaccatgatg gcttgtgaac taactgcaag gcactccgtc atggtaagcg agtaggtccc     3000

acctcctagt gtgccgctca ttgctttaca cagtagaatc ttatttgagt gctaattgtt     3060

gtctttgctg ctttactgtg ttgttataga aaatgtaagc tgtacagtga ataagttatt     3120

gaagcatgtg taaacactgt tatatatctt ttctcctaga tggggaattt tgaataaaat     3180

acctttgaaa ttctgtgt                                                   3198


<210>  17
<211>  481
<212>  PRT
<213>  Mus musculus

<400>  17

Met Ser Thr Ile Cys Pro Pro Pro Ser Pro Ala Val Ala Lys Thr Glu 
1               5                   10                  15      


Ile Ala Leu Ser Gly Glu Ser Pro Leu Leu Ala Ala Thr Phe Ala Tyr 
            20                  25                  30          


Trp Asp Asn Ile Leu Gly Pro Arg Val Arg His Ile Trp Ala Pro Lys 
        35                  40                  45              


Thr Asp Gln Val Leu Leu Ser Asp Gly Glu Ile Thr Phe Leu Ala Asn 
    50                  55                  60                  


His Thr Leu Asn Gly Glu Ile Leu Arg Asn Ala Glu Ser Gly Ala Ile 
65                  70                  75                  80  


Asp Val Lys Phe Phe Val Leu Ser Glu Lys Gly Val Ile Ile Val Ser 
                85                  90                  95      


Leu Ile Phe Asp Gly Asn Trp Asn Gly Asp Arg Ser Thr Tyr Gly Leu 
            100                 105                 110         


Ser Ile Ile Leu Pro Gln Thr Glu Leu Ser Phe Tyr Leu Pro Leu His 
        115                 120                 125             


Arg Val Cys Val Asp Arg Leu Thr His Ile Ile Arg Lys Gly Arg Ile 
    130                 135                 140                 


Trp Met His Lys Glu Arg Gln Glu Asn Val Gln Lys Ile Val Leu Glu 
145                 150                 155                 160 


Gly Thr Glu Arg Met Glu Asp Gln Gly Gln Ser Ile Ile Pro Met Leu 
                165                 170                 175     


Thr Gly Glu Val Ile Pro Val Met Glu Leu Leu Ala Ser Met Lys Ser 
            180                 185                 190         


His Ser Val Pro Glu Asp Ile Asp Ile Ala Asp Thr Val Leu Asn Asp 
        195                 200                 205             


Asp Asp Ile Gly Asp Ser Cys His Glu Gly Phe Leu Leu Asn Ala Ile 
    210                 215                 220                 


Ser Ser His Leu Gln Thr Cys Gly Cys Ser Val Val Val Gly Ser Ser 
225                 230                 235                 240 


Ala Glu Lys Val Asn Lys Ile Val Arg Thr Leu Cys Leu Phe Leu Thr 
                245                 250                 255     


Pro Ala Glu Arg Lys Cys Ser Arg Leu Cys Glu Ala Glu Ser Ser Phe 
            260                 265                 270         


Lys Tyr Glu Ser Gly Leu Phe Val Gln Gly Leu Leu Lys Asp Ala Thr 
        275                 280                 285             


Gly Ser Phe Val Leu Pro Phe Arg Gln Val Met Tyr Ala Pro Tyr Pro 
    290                 295                 300                 


Thr Thr His Ile Asp Val Asp Val Asn Thr Val Lys Gln Met Pro Pro 
305                 310                 315                 320 


Cys His Glu His Ile Tyr Asn Gln Arg Arg Tyr Met Arg Ser Glu Leu 
                325                 330                 335     


Thr Ala Phe Trp Arg Ala Thr Ser Glu Glu Asp Met Ala Gln Asp Thr 
            340                 345                 350         


Ile Ile Tyr Thr Asp Glu Ser Phe Thr Pro Asp Leu Asn Ile Phe Gln 
        355                 360                 365             


Asp Val Leu His Arg Asp Thr Leu Val Lys Ala Phe Leu Asp Gln Val 
    370                 375                 380                 


Phe His Leu Lys Pro Gly Leu Ser Leu Arg Ser Thr Phe Leu Ala Gln 
385                 390                 395                 400 


Phe Leu Leu Ile Leu His Arg Lys Ala Leu Thr Leu Ile Lys Tyr Ile 
                405                 410                 415     


Glu Asp Asp Thr Gln Lys Gly Lys Lys Pro Phe Lys Ser Leu Arg Asn 
            420                 425                 430         


Leu Lys Ile Asp Leu Asp Leu Thr Ala Glu Gly Asp Leu Asn Ile Ile 
        435                 440                 445             


Met Ala Leu Ala Glu Lys Ile Lys Pro Gly Leu His Ser Phe Ile Phe 
    450                 455                 460                 


Gly Arg Pro Phe Tyr Thr Ser Val Gln Glu Arg Asp Val Leu Met Thr 
465                 470                 475                 480 


Phe 
    


<210>  18
<211>  3435
<212>  DNA
<213>  Rattus norvegicus

<400>  18
cgtttgtagt gtcagccatc ccaattgcct gttccttctc tgtgggagtg gtgtctagac       60

agtccaggca gggtatgcta ggcaggtgcg ttttggttgc ctcagatcgc aacttgactc      120

cataacggtg accaaagaca aaagaaggaa accagattaa aaagaaccgg acacagaccc      180

ctgcagaatc tggagcggcc gtggttgggg gcggggctac gacggggcgg actcgggggc      240

gtgggagggc ggggccgggg cggggcccgg agccggctgc ggttgcggtc cctgcgccgg      300

cggtgaaggc gcagcggcgg cgagtggcta ttgcaagcgt ttggataatg tgagacctgg      360

gatgcaggga tgtcgactat ctgcccccca ccatctcctg ctgttgccaa gacagagatt      420

gctttaagtg gtgaatcacc cttgttggcg gctacctttg cttactggga taatattctt      480

ggtcctagag taaggcacat ttgggctcca aagacagacc aagtactcct cagtgatgga      540

gaaatcactt ttcttgccaa ccacactctg aatggagaaa ttcttcggaa tgcggagagt      600

ggggcaatag atgtaaagtt ttttgtctta tctgaaaagg gcgtcattat tgtttcatta      660

atcttcgacg ggaactggaa cggagatcgg agcacttacg gactatcaat tatactgccg      720

cagacggagc tgagtttcta cctcccactg cacagagtgt gtgttgacag gctaacgcac      780

atcattcgaa aaggaaggat atggatgcac aaggaaagac aagaaaatgt ccagaaaatt      840

gtcttggaag gcaccgagag gatggaagat cagggtcaga gtatcatccc tatgcttact      900

ggggaggtca tccctgtgat ggagctgctt gcgtctatga gatcacacag tgttcctgaa      960

gacctcgata tagctgatac agtactcaat gatgatgaca ttggtgacag ctgtcatgaa     1020

ggctttcttc tcaatgccat cagctcacat ctgcagacct gcggctgttc tgtggtggta     1080

ggcagcagtg cagagaaagt aaataagata gtaagaacac tgtgcctttt tctgacacca     1140

gcagagagga agtgctccag gctgtgtgaa gccgaatcgt cctttaaata cgaatctgga     1200

ctctttgtac aaggcttgct aaaggatgcg actggcagtt ttgtactacc tttccggcaa     1260

gttatgtatg ccccttatcc caccacacac atcgatgtgg atgtcaacac tgtcaagcag     1320

atgccaccgt gtcatgaaca tatttataat caacgcagat acatgaggtc agagctgaca     1380

gccttctgga gggcaacttc agaagaggac atggctcagg acaccatcat ctacacagat     1440

gagagcttca ctcctgattt gaatattttc caagatgtct tacacagaga cactctagtg     1500

aaagcctttc tggatcaggt cttccatttg aagcctggcc tgtctctcag gagtactttc     1560

cttgcacagt tcctcctcat tcttcacaga aaagccttga cactaatcaa gtacatagag     1620

gatgacacgc agaaggggaa aaagcccttt aagtctcttc ggaacctgaa gatagatctt     1680

gatttaacag cagagggcga ccttaacata ataatggctc tagctgagaa aattaagcca     1740

ggcctacact ctttcatctt cgggagacct ttctacacta gtgtccaaga acgtgatgtt     1800

ctaatgactt tttaaacatg tggtttgctc cgtgtgtctc atgacagtca cacttgctgt     1860

tacagtgtct cagcgctttg gacacatcct tcctccaggg tcctgccgca ggacacgtta     1920

cactacactt gtcagtagag gtctgtacca gatgtcaggt acatcgttgt agtgaatgtc     1980

tcttttccta gactagatgt accctcgtag ggacttatgt ttacaaccct cctaagtact     2040

agtgctgtct tgtaaggata cgaatgaagg gatgtaaact tcaccacaac tgctggttgg     2100

ttttgttgtt tttgtttttt gaaacttata attcatggtt tacatgcatc acactgaaac     2160

cctagttagc tttttacagg taagctgtga gttgactgcc tgtccctgtg ttctctggcc     2220

tgtacgatct gtggcgtgta ggatcacttt tgcaacaact aaaaactaaa gcactttgtt     2280

tgcagttcta cagaaagcaa cttagtctgt ctgcagattc gtttttgaaa gaagacatga     2340

gaaagcggag ttttaggtga agtcagttgt tggatcttcc tttatagact tagtccttta     2400

gatgtggtct gtatagacat gcccaaccat catgcatggg cactgaatat cgtgaactgt     2460

ggtatgcttt ttgttggttt attgtacttc tgtcaaagaa agtggcattg gtttttataa     2520

ttgttgccaa gttttaaggt taattttcat tatttttgag ccaaattaaa atgtgcacct     2580

cctgtgcctt tcccaatctt ggaaaatata atttcttggc agaaggtcag atttcagggc     2640

ccagtcactt tcgtctgact tccctttgca cagtccgcca tgggcctggc ttagaagttc     2700

ttgtaaacta tgccagagag tacattcgct gataaaatct tctttgcaga gcaggagagc     2760

ttcttgcctc tttcctttca tttctgcctg gactttggtg ttctccacgt tccctgcatc     2820

ctaaggacag caggagaact ctgaccccag tgctatttct ctaggtgcta ttgtggcaaa     2880

ctcaagcggt ccgtctctgt ccctgtaacg ttcgtacctt gctggctgtg aagtactgac     2940

tggtaaagct ccgtgctaca gcagtgtagg gtatacacaa acacaagtaa gtgttttatt     3000

taaaactgtg gacttagcat aaaaagggag actatattta ttttttacaa aagggataaa     3060

aatggaaccc tttcctcacc caccagattt agtcagaaaa aaacattcta ttctgaaagg     3120

tcacagtggt tttgacatga cacatcagaa caacgcacac tgtccatgat ggcttatgaa     3180

ctccaagtca ctccatcatg gtaaatgggt agatccctcc ttctagtgtg ccacaccatt     3240

gcttcccaca gtagaatctt atttaagtgc taagtgttgt ctctgctggt ttactctgtt     3300

gttttagaga atgtaagttg tatagtgaat aagttattga agcatgtgta aacactgtta     3360

tacatctttt ctcctagatg gggaatttgg aataaaatac ctttaaaatt caaaaaaaaa     3420

aaaaaaaaaa aaaaa                                                      3435


<210>  19
<211>  481
<212>  PRT
<213>  Rattus norvegicus

<400>  19

Met Ser Thr Ile Cys Pro Pro Pro Ser Pro Ala Val Ala Lys Thr Glu 
1               5                   10                  15      


Ile Ala Leu Ser Gly Glu Ser Pro Leu Leu Ala Ala Thr Phe Ala Tyr 
            20                  25                  30          


Trp Asp Asn Ile Leu Gly Pro Arg Val Arg His Ile Trp Ala Pro Lys 
        35                  40                  45              


Thr Asp Gln Val Leu Leu Ser Asp Gly Glu Ile Thr Phe Leu Ala Asn 
    50                  55                  60                  


His Thr Leu Asn Gly Glu Ile Leu Arg Asn Ala Glu Ser Gly Ala Ile 
65                  70                  75                  80  


Asp Val Lys Phe Phe Val Leu Ser Glu Lys Gly Val Ile Ile Val Ser 
                85                  90                  95      


Leu Ile Phe Asp Gly Asn Trp Asn Gly Asp Arg Ser Thr Tyr Gly Leu 
            100                 105                 110         


Ser Ile Ile Leu Pro Gln Thr Glu Leu Ser Phe Tyr Leu Pro Leu His 
        115                 120                 125             


Arg Val Cys Val Asp Arg Leu Thr His Ile Ile Arg Lys Gly Arg Ile 
    130                 135                 140                 


Trp Met His Lys Glu Arg Gln Glu Asn Val Gln Lys Ile Val Leu Glu 
145                 150                 155                 160 


Gly Thr Glu Arg Met Glu Asp Gln Gly Gln Ser Ile Ile Pro Met Leu 
                165                 170                 175     


Thr Gly Glu Val Ile Pro Val Met Glu Leu Leu Ala Ser Met Arg Ser 
            180                 185                 190         


His Ser Val Pro Glu Asp Leu Asp Ile Ala Asp Thr Val Leu Asn Asp 
        195                 200                 205             


Asp Asp Ile Gly Asp Ser Cys His Glu Gly Phe Leu Leu Asn Ala Ile 
    210                 215                 220                 


Ser Ser His Leu Gln Thr Cys Gly Cys Ser Val Val Val Gly Ser Ser 
225                 230                 235                 240 


Ala Glu Lys Val Asn Lys Ile Val Arg Thr Leu Cys Leu Phe Leu Thr 
                245                 250                 255     


Pro Ala Glu Arg Lys Cys Ser Arg Leu Cys Glu Ala Glu Ser Ser Phe 
            260                 265                 270         


Lys Tyr Glu Ser Gly Leu Phe Val Gln Gly Leu Leu Lys Asp Ala Thr 
        275                 280                 285             


Gly Ser Phe Val Leu Pro Phe Arg Gln Val Met Tyr Ala Pro Tyr Pro 
    290                 295                 300                 


Thr Thr His Ile Asp Val Asp Val Asn Thr Val Lys Gln Met Pro Pro 
305                 310                 315                 320 


Cys His Glu His Ile Tyr Asn Gln Arg Arg Tyr Met Arg Ser Glu Leu 
                325                 330                 335     


Thr Ala Phe Trp Arg Ala Thr Ser Glu Glu Asp Met Ala Gln Asp Thr 
            340                 345                 350         


Ile Ile Tyr Thr Asp Glu Ser Phe Thr Pro Asp Leu Asn Ile Phe Gln 
        355                 360                 365             


Asp Val Leu His Arg Asp Thr Leu Val Lys Ala Phe Leu Asp Gln Val 
    370                 375                 380                 


Phe His Leu Lys Pro Gly Leu Ser Leu Arg Ser Thr Phe Leu Ala Gln 
385                 390                 395                 400 


Phe Leu Leu Ile Leu His Arg Lys Ala Leu Thr Leu Ile Lys Tyr Ile 
                405                 410                 415     


Glu Asp Asp Thr Gln Lys Gly Lys Lys Pro Phe Lys Ser Leu Arg Asn 
            420                 425                 430         


Leu Lys Ile Asp Leu Asp Leu Thr Ala Glu Gly Asp Leu Asn Ile Ile 
        435                 440                 445             


Met Ala Leu Ala Glu Lys Ile Lys Pro Gly Leu His Ser Phe Ile Phe 
    450                 455                 460                 


Gly Arg Pro Phe Tyr Thr Ser Val Gln Glu Arg Asp Val Leu Met Thr 
465                 470                 475                 480 


Phe 
    


<210>  20
<211>  100
<212>  DNA
<213>  Mus musculus

<400>  20
gaaccgcggc gcgtcaagca gagacgagtt ccgcccacgt gaaagatggc gtttgtagtg       60

acagccatcc caattgccct ttccttctag gtggaaagtg                            100


<210>  21
<211>  2648
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  floxed neo cassette of 8026 plus lox sites

<400>  21
ataacttcgt ataatgtatg ctatacgaag ttatatgcat ggcctccgcg ccgggttttg       60

gcgcctcccg cgggcgcccc cctcctcacg gcgagcgctg ccacgtcaga cgaagggcgc      120

agcgagcgtc ctgatccttc cgcccggacg ctcaggacag cggcccgctg ctcataagac      180

tcggccttag aaccccagta tcagcagaag gacattttag gacgggactt gggtgactct      240

agggcactgg ttttctttcc agagagcgga acaggcgagg aaaagtagtc ccttctcggc      300

gattctgcgg agggatctcc gtggggcggt gaacgccgat gattatataa ggacgcgccg      360

ggtgtggcac agctagttcc gtcgcagccg ggatttgggt cgcggttctt gtttgtggat      420

cgctgtgatc gtcacttggt gagtagcggg ctgctgggct ggccggggct ttcgtggccg      480

ccgggccgct cggtgggacg gaagcgtgtg gagagaccgc caagggctgt agtctgggtc      540

cgcgagcaag gttgccctga actgggggtt ggggggagcg cagcaaaatg gcggctgttc      600

ccgagtcttg aatggaagac gcttgtgagg cgggctgtga ggtcgttgaa acaaggtggg      660

gggcatggtg ggcggcaaga acccaaggtc ttgaggcctt cgctaatgcg ggaaagctct      720

tattcgggtg agatgggctg gggcaccatc tggggaccct gacgtgaagt ttgtcactga      780

ctggagaact cggtttgtcg tctgttgcgg gggcggcagt tatggcggtg ccgttgggca      840

gtgcacccgt acctttggga gcgcgcgccc tcgtcgtgtc gtgacgtcac ccgttctgtt      900

ggcttataat gcagggtggg gccacctgcc ggtaggtgtg cggtaggctt ttctccgtcg      960

caggacgcag ggttcgggcc tagggtaggc tctcctgaat cgacaggcgc cggacctctg     1020

gtgaggggag ggataagtga ggcgtcagtt tctttggtcg gttttatgta cctatcttct     1080

taagtagctg aagctccggt tttgaactat gcgctcgggg ttggcgagtg tgttttgtga     1140

agttttttag gcaccttttg aaatgtaatc atttgggtca atatgtaatt ttcagtgtta     1200

gactagtaaa ttgtccgcta aattctggcc gtttttggct tttttgttag acgtgttgac     1260

aattaatcat cggcatagta tatcggcata gtataatacg acaaggtgag gaactaaacc     1320

atgggatcgg ccattgaaca agatggattg cacgcaggtt ctccggccgc ttgggtggag     1380

aggctattcg gctatgactg ggcacaacag acaatcggct gctctgatgc cgccgtgttc     1440

cggctgtcag cgcaggggcg cccggttctt tttgtcaaga ccgacctgtc cggtgccctg     1500

aatgaactgc aggacgaggc agcgcggcta tcgtggctgg ccacgacggg cgttccttgc     1560

gcagctgtgc tcgacgttgt cactgaagcg ggaagggact ggctgctatt gggcgaagtg     1620

ccggggcagg atctcctgtc atctcacctt gctcctgccg agaaagtatc catcatggct     1680

gatgcaatgc ggcggctgca tacgcttgat ccggctacct gcccattcga ccaccaagcg     1740

aaacatcgca tcgagcgagc acgtactcgg atggaagccg gtcttgtcga tcaggatgat     1800

ctggacgaag agcatcaggg gctcgcgcca gccgaactgt tcgccaggct caaggcgcgc     1860

atgcccgacg gcgatgatct cgtcgtgacc catggcgatg cctgcttgcc gaatatcatg     1920

gtggaaaatg gccgcttttc tggattcatc gactgtggcc ggctgggtgt ggcggaccgc     1980

tatcaggaca tagcgttggc tacccgtgat attgctgaag agcttggcgg cgaatgggct     2040

gaccgcttcc tcgtgcttta cggtatcgcc gctcccgatt cgcagcgcat cgccttctat     2100

cgccttcttg acgagttctt ctgaggggat ccgctgtaag tctgcagaaa ttgatgatct     2160

attaaacaat aaagatgtcc actaaaatgg aagtttttcc tgtcatactt tgttaagaag     2220

ggtgagaaca gagtacctac attttgaatg gaaggattgg agctacgggg gtgggggtgg     2280

ggtgggatta gataaatgcc tgctctttac tgaaggctct ttactattgc tttatgataa     2340

tgtttcatag ttggatatca taatttaaac aagcaaaacc aaattaaggg ccagctcatt     2400

cctcccactc atgatctata gatctataga tctctcgtgg gatcattgtt tttctcttga     2460

ttcccacttt gtggttctaa gtactgtggt ttccaaatgt gtcagtttca tagcctgaag     2520

aacgagatca gcagcctctg ttccacatac acttcattct cagtattgtt ttgccaagtt     2580

ctaattccat cagacctcga cctgcagccc ctagataact tcgtataatg tatgctatac     2640

gaagttat                                                              2648


<210>  22
<211>  100
<212>  DNA
<213>  Mus musculus

<400>  22
attgtgactt gggcatcact tgactgatgg taatcagttg cagagagaga agtgcactga       60

ttaagtctgt ccacacaggg tctgtctggc caggagtgca                            100


<210>  23
<211>  100
<212>  DNA
<213>  Mus musculus

<400>  23
gaaccgcggc gcgtcaagca gagacgagtt ccgcccacgt gaaagatggc gtttgtagtg       60

acagccatcc caattgccct ttccttctag gtggaaagtg                            100


<210>  24
<211>  2648
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  floxed cassette of 8028 plus lox sites

<400>  24
ataacttcgt ataatgtatg ctatacgaag ttatatgcat ggcctccgcg ccgggttttg       60

gcgcctcccg cgggcgcccc cctcctcacg gcgagcgctg ccacgtcaga cgaagggcgc      120

agcgagcgtc ctgatccttc cgcccggacg ctcaggacag cggcccgctg ctcataagac      180

tcggccttag aaccccagta tcagcagaag gacattttag gacgggactt gggtgactct      240

agggcactgg ttttctttcc agagagcgga acaggcgagg aaaagtagtc ccttctcggc      300

gattctgcgg agggatctcc gtggggcggt gaacgccgat gattatataa ggacgcgccg      360

ggtgtggcac agctagttcc gtcgcagccg ggatttgggt cgcggttctt gtttgtggat      420

cgctgtgatc gtcacttggt gagtagcggg ctgctgggct ggccggggct ttcgtggccg      480

ccgggccgct cggtgggacg gaagcgtgtg gagagaccgc caagggctgt agtctgggtc      540

cgcgagcaag gttgccctga actgggggtt ggggggagcg cagcaaaatg gcggctgttc      600

ccgagtcttg aatggaagac gcttgtgagg cgggctgtga ggtcgttgaa acaaggtggg      660

gggcatggtg ggcggcaaga acccaaggtc ttgaggcctt cgctaatgcg ggaaagctct      720

tattcgggtg agatgggctg gggcaccatc tggggaccct gacgtgaagt ttgtcactga      780

ctggagaact cggtttgtcg tctgttgcgg gggcggcagt tatggcggtg ccgttgggca      840

gtgcacccgt acctttggga gcgcgcgccc tcgtcgtgtc gtgacgtcac ccgttctgtt      900

ggcttataat gcagggtggg gccacctgcc ggtaggtgtg cggtaggctt ttctccgtcg      960

caggacgcag ggttcgggcc tagggtaggc tctcctgaat cgacaggcgc cggacctctg     1020

gtgaggggag ggataagtga ggcgtcagtt tctttggtcg gttttatgta cctatcttct     1080

taagtagctg aagctccggt tttgaactat gcgctcgggg ttggcgagtg tgttttgtga     1140

agttttttag gcaccttttg aaatgtaatc atttgggtca atatgtaatt ttcagtgtta     1200

gactagtaaa ttgtccgcta aattctggcc gtttttggct tttttgttag acgtgttgac     1260

aattaatcat cggcatagta tatcggcata gtataatacg acaaggtgag gaactaaacc     1320

atgggatcgg ccattgaaca agatggattg cacgcaggtt ctccggccgc ttgggtggag     1380

aggctattcg gctatgactg ggcacaacag acaatcggct gctctgatgc cgccgtgttc     1440

cggctgtcag cgcaggggcg cccggttctt tttgtcaaga ccgacctgtc cggtgccctg     1500

aatgaactgc aggacgaggc agcgcggcta tcgtggctgg ccacgacggg cgttccttgc     1560

gcagctgtgc tcgacgttgt cactgaagcg ggaagggact ggctgctatt gggcgaagtg     1620

ccggggcagg atctcctgtc atctcacctt gctcctgccg agaaagtatc catcatggct     1680

gatgcaatgc ggcggctgca tacgcttgat ccggctacct gcccattcga ccaccaagcg     1740

aaacatcgca tcgagcgagc acgtactcgg atggaagccg gtcttgtcga tcaggatgat     1800

ctggacgaag agcatcaggg gctcgcgcca gccgaactgt tcgccaggct caaggcgcgc     1860

atgcccgacg gcgatgatct cgtcgtgacc catggcgatg cctgcttgcc gaatatcatg     1920

gtggaaaatg gccgcttttc tggattcatc gactgtggcc ggctgggtgt ggcggaccgc     1980

tatcaggaca tagcgttggc tacccgtgat attgctgaag agcttggcgg cgaatgggct     2040

gaccgcttcc tcgtgcttta cggtatcgcc gctcccgatt cgcagcgcat cgccttctat     2100

cgccttcttg acgagttctt ctgaggggat ccgctgtaag tctgcagaaa ttgatgatct     2160

attaaacaat aaagatgtcc actaaaatgg aagtttttcc tgtcatactt tgttaagaag     2220

ggtgagaaca gagtacctac attttgaatg gaaggattgg agctacgggg gtgggggtgg     2280

ggtgggatta gataaatgcc tgctctttac tgaaggctct ttactattgc tttatgataa     2340

tgtttcatag ttggatatca taatttaaac aagcaaaacc aaattaaggg ccagctcatt     2400

cctcccactc atgatctata gatctataga tctctcgtgg gatcattgtt tttctcttga     2460

ttcccacttt gtggttctaa gtactgtggt ttccaaatgt gtcagtttca tagcctgaag     2520

aacgagatca gcagcctctg ttccacatac acttcattct cagtattgtt ttgccaagtt     2580

ctaattccat cagacctcga cctgcagccc ctagataact tcgtataatg tatgctatac     2640

gaagttat                                                              2648


<210>  25
<211>  100
<212>  DNA
<213>  Mus musculus

<400>  25
attgtgactt gggcatcact tgactgatgg taatcagttg cagagagaga agtgcactga       60

ttaagtctgt ccacacaggg tctgtctggc caggagtgca                            100


<210>  26
<211>  680
<212>  DNA
<213>  Mus musculus

<400>  26
ccagtagcag cacccacgtc caccttctgt ctagtaatgt ccaacacctc cctcagtcca       60

aacactgctc tgcatccatg tggctcccat ttatacctga agcacttgat ggggcctcaa      120

tgttttacta gagcccaccc ccctgcaact ctgagaccct ctggatttgt ctgtcagtgc      180

ctcactgggg cgttggataa tttcttaaaa ggtcaagttc cctcagcagc attctctgag      240

cagtctgaag atgtgtgctt ttcacagttc aaatccatgt ggctgtttca cccacctgcc      300

tggccttggg ttatctatca ggacctagcc tagaagcagg tgtgtggcac ttaacaccta      360

agctgagtga ctaactgaac actcaagtgg atgccatctt tgtcacttct tgactgtgac      420

acaagcaact cctgatgcca aagccctgcc cacccctctc atgcccatat ttggacatgg      480

tacaggtcct cactggccat ggtctgtgag gtcctggtcc tctttgactt cataattcct      540

aggggccact agtatctata agaggaagag ggtgctggct cccaggccac agcccacaaa      600

attccacctg ctcacaggtt ggctggctcg acccaggtgg tgtcccctgc tctgagccag      660

ctcccggcca agccagcacc                                                  680


<210>  27
<211>  1052
<212>  DNA
<213>  Mus musculus

<400>  27
tgccatcatc acaggatgtc cttccttctc cagaagacag actggggctg aaggaaaagc       60

cggccaggct cagaacgagc cccactaatt actgcctcca acagctttcc actcactgcc      120

cccagcccaa catccccttt ttaactggga agcattccta ctctccattg tacgcacacg      180

ctcggaagcc tggctgtggg tttgggcatg agaggcaggg acaacaaaac cagtatatat      240

gattataact ttttcctgtt tccctatttc caaatggtcg aaaggaggaa gttaggtcta      300

cctaagctga atgtattcag ttagcaggag aaatgaaatc ctatacgttt aatactagag      360

gagaaccgcc ttagaatatt tatttcattg gcaatgactc caggactaca cagcgaaatt      420

gtattgcatg tgctgccaaa atactttagc tctttccttc gaagtacgtc ggatcctgta      480

attgagacac cgagtttagg tgactagggt tttcttttga ggaggagtcc cccaccccgc      540

cccgctctgc cgcgacagga agctagcgat ccggaggact tagaatacaa tcgtagtgtg      600

ggtaaacatg gagggcaagc gcctgcaaag ggaagtaaga agattcccag tccttgttga      660

aatccatttg caaacagagg aagctgccgc gggtcgcagt cggtgggggg aagccctgaa      720

ccccacgctg cacggctggg ctggccaggt gcggccacgc ccccatcgcg gcggctggta      780

ggagtgaatc agaccgtcag tattggtaaa gaagtctgcg gcagggcagg gagggggaag      840

agtagtcagt cgctcgctca ctcgctcgct cgcacagaca ctgctgcagt gacactcggc      900

cctccagtgt cgcggagacg caagagcagc gcgcagcacc tgtccgcccg gagcgagccc      960

ggcccgcggc cgtagaaaag gagggaccgc cgaggtgcgc gtcagtactg ctcagcccgg     1020

cagggacgcg ggaggatgtg gactgggtgg ac                                   1052


<210>  28
<211>  2008
<212>  DNA
<213>  Mus musculus

<400>  28
gtggtgctga ctcagcatcg gttaataaac cctctgcagg aggctggatt tcttttgttt       60

aattatcact tggacctttc tgagaactct taagaattgt tcattcgggt ttttttgttt      120

tgttttggtt tggttttttt gggttttttt tttttttttt tttttggttt ttggagacag      180

ggtttctctg tatatagccc tggcacaaga gcaagctaac agcctgtttc ttcttggtgc      240

tagcgccccc tctggcagaa aatgaaataa caggtggacc tacaaccccc cccccccccc      300

ccagtgtatt ctactcttgt ccccggtata aatttgattg ttccgaacta cataaattgt      360

agaaggattt tttagatgca catatcattt tctgtgatac cttccacaca cccctccccc      420

ccaaaaaaat ttttctggga aagtttcttg aaaggaaaac agaagaacaa gcctgtcttt      480

atgattgagt tgggcttttg ttttgctgtg tttcatttct tcctgtaaac aaatactcaa      540

atgtccactt cattgtatga ctaagttggt atcattaggt tgggtctggg tgtgtgaatg      600

tgggtgtgga tctggatgtg ggtgggtgtg tatgccccgt gtgtttagaa tactagaaaa      660

gataccacat cgtaaacttt tgggagagat gatttttaaa aatgggggtg ggggtgaggg      720

gaacctgcga tgaggcaagc aagataaggg gaagacttga gtttctgtga tctaaaaagt      780

cgctgtgatg ggatgctggc tataaatggg cccttagcag cattgtttct gtgaattgga      840

ggatccctgc tgaaggcaaa agaccattga aggaagtacc gcatctggtt tgttttgtaa      900

tgagaagcag gaatgcaagg tccacgctct taataataaa caaacaggac attgtatgcc      960

atcatcacag gatgtccttc cttctccaga agacagactg gggctgaagg aaaagccggc     1020

caggctcaga acgagcccca ctaattactg cctccaacag ctttccactc actgccccca     1080

gcccaacatc ccctttttaa ctgggaagca ttcctactct ccattgtacg cacacgctcg     1140

gaagcctggc tgtgggtttg ggcatgagag gcagggacaa caaaaccagt atatatgatt     1200

ataacttttt cctgtttccc tatttccaaa tggtcgaaag gaggaagtta ggtctaccta     1260

agctgaatgt attcagttag caggagaaat gaaatcctat acgtttaata ctagaggaga     1320

accgccttag aatatttatt tcattggcaa tgactccagg actacacagc gaaattgtat     1380

tgcatgtgct gccaaaatac tttagctctt tccttcgaag tacgtcggat cctgtaattg     1440

agacaccgag tttaggtgac tagggttttc ttttgaggag gagtccccca ccccgccccg     1500

ctctgccgcg acaggaagct agcgatccgg aggacttaga atacaatcgt agtgtgggta     1560

aacatggagg gcaagcgcct gcaaagggaa gtaagaagat tcccagtcct tgttgaaatc     1620

catttgcaaa cagaggaagc tgccgcgggt cgcagtcggt ggggggaagc cctgaacccc     1680

acgctgcacg gctgggctgg ccaggtgcgg ccacgccccc atcgcggcgg ctggtaggag     1740

tgaatcagac cgtcagtatt ggtaaagaag tctgcggcag ggcagggagg gggaagagta     1800

gtcagtcgct cgctcactcg ctcgctcgca cagacactgc tgcagtgaca ctcggccctc     1860

cagtgtcgcg gagacgcaag agcagcgcgc agcacctgtc cgcccggagc gagcccggcc     1920

cgcggccgta gaaaaggagg gaccgccgag gtgcgcgtca gtactgctca gcccggcagg     1980

gacgcgggag gatgtggact gggtggac                                        2008


<210>  29
<211>  252
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Southern blot probe

<400>  29
ccggggcggg gctgcggttg cggtgcctgc gcccgcggcg gcggaggcgc aggcggtggc       60

gagtgggtga gtgaggaggc ggcatcctgg cgggtggctg tttggggttc ggctgccggg      120

aagaggcgcg ggtagaagcg ggggctctcc tcagagctcg acgcattttt actttccctc      180

tcatttctct gaccgaagct gggtgtcggg ctttcgcctc tagcgactgg tggaattgcc      240

tgcatccggg cc                                                          252


<210>  30
<211>  39
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Asuragen 2-Primer Fwd

<400>  30
tgcgcctccg ccgccgcggg cgcaggcacc gcaaccgca                              39


<210>  31
<211>  35
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Asuragen 2-Primer Rev

<400>  31
cgcagcctgt agcaagctct ggaactcagg agtcg                                  35


<210>  32
<211>  36
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Asuragen 3-Primer Fwd

<400>  32
atgcaggcaa ttccaccagt cgctagaggc gaaagc                                 36


<210>  33
<211>  40
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Asuragen 3-Primer Rev

<400>  33
taaccagaag aaaacaagga gggaaacaac cgcagcctgt                             40


<210>  34
<211>  158
<212>  DNA
<213>  Homo sapiens

<400>  34
acgtaaccta cggtgtcccg ctaggaaaga gaggtgcgtc aaacagcgac aagttccgcc       60

cacgtaaaag atgacgcttg gtgtgtcagc cgtccctgct gcccggttgc ttctcttttg      120

ggggcggggt ctagcaagag caggtgtggg tttaggag                              158


<210>  35
<211>  487
<212>  DNA
<213>  Homo sapiens

<400>  35
tatctccgga gcatttggat aatgtgacag ttggaatgca gtgatgtcga ctctttgccc       60

accgccatct ccagctgttg ccaagacaga gattgcttta agtggcaaat cacctttatt      120

agcagctact tttgcttact gggacaatat tcttggtcct agagtaaggc acatttgggc      180

tccaaagaca gaacaggtac ttctcagtga tggagaaata acttttcttg ccaaccacac      240

tctaaatgga gaaatccttc gaaatgcaga gagtggtgct atagatgtaa agttttttgt      300

cttgtctgaa aagggagtga ttattgtttc attaatcttt gatggaaact ggaatgggga      360

tcgcagcaca tatggactat caattatact tccacagaca gaacttagtt tctacctccc      420

acttcataga gtgtgtgttg atagattaac acatataatc cggaaaggaa gaatatggat      480

gcataag                                                                487


<210>  36
<211>  198
<212>  DNA
<213>  Homo sapiens

<400>  36
gggtctagca agagcaggtg tgggtttagg aggtgtgtgt ttttgttttt cccaccctct       60

ctccccacta cttgctctca cagtactcgc tgagggtgaa caagaaaaga cctgataaag      120

attaaccaga agaaaacaag gagggaaaca accgcagcct gtagcaagct ctggaactca      180

ggagtcgcgc gctatgcg                                                    198


<210>  37
<211>  118
<212>  DNA
<213>  Homo sapiens

<400>  37
gcgatcgcgg ggcgtggtcg gggcgggccc gggggcgggc ccggggcggg gctgcggttg       60

cggtgcctgc gcccgcggcg gcggaggcgc aggcggtggc gagtgggtga gtgaggag        118


<210>  38
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  38
agtactgtga gagcaagtag                                                   20


<210>  39
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  39
gctctcacag tactcgctga                                                   20


<210>  40
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  40
ccgcagcctg tagcaagctc                                                   20


<210>  41
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  41
cggccgctag cgcgatcgcg                                                   20


<210>  42
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  42
acgccccgcg atcgcgctag                                                   20


<210>  43
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  43
tggcgagtgg gtgagtgagg                                                   20


<210>  44
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  44
ggaagaggcg cgggtagaag                                                   20


<210>  45
<211>  1302
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  45
gaacttacgg agtcccacga gggaaccgcg gcgcgtcaag cagagacgag ttccgcccac       60

gtgaaagatg gcgtttgtag tgacagccat cccaattgcc ctttccttct aggtggaaag      120

tggggtctag caagagcagg tgtgggttta ggaggtgtgt gtttttgttt ttcccaccct      180

ctctccccac tacttgctct cacagtactc gctgagggtg aacaagaaaa gacctgataa      240

agattaacca gaagaaaaca aggagggaaa caaccgcagc ctgtagcaag ctctggaact      300

caggagtcgc gcgctatgcg atcgccgtct cggggccggg gccggggccg gggccggggc      360

cggggccggg gccggggccg gggccggggc cggggccggg gccggggccg gggccggggc      420

cggggccggg gccggggccg gggccggggc cggggccggg gccggggccg gggccggggc      480

cggggccggg gccggggccg gggccggggc cggggccggg gccggggccg gggccggggc      540

cggggccggg gccggggccg gggccggggc cggggccggg gccggggccg gggccggggc      600

cggggccggg gccggggccg gggccggggc cggggccggg gccggggccg gggccggggc      660

cggggccggg gccggggccg gggccggggc cggggccggg gccggggccg gggccggggc      720

cggggccggg gccggggccg gggccggggc cggggccggg gccggggccg gggccggggc      780

cggggccggg gccggggccg gggccggggc cggggccggg gccggggccg gggccggggc      840

cggggccggg gccggggccg gggccggggc cggggccggg gccgagaccc tcgagggccg      900

gccgctagcg cgatcgcggg gcgtggtcgg ggcgggcccg ggggcgggcc cggggcgggg      960

ctgcggttgc ggtgcctgcg cccgcggcgg cggaggcgca ggcggtgcga gtgggtgagt     1020

gaggaggcgg catcctggcg ggtggctgtt tggggttcgg ctgccgggaa gaggcgcggg     1080

tagaagcggg ggctctcctc agagctcgac gcatttttac tttccctctc atttctctga     1140

ccgaagctgg gtgtcgggct ttcgcctcta gcgactggtg gaattgcctg catccgggcc     1200

ccgggcttcc cggcggcggc ggcggcggcg gcggcgcagg gacaagggat ggggatctgg     1260

cctcttcctt gctttcccgc cctcagtacc cgagctgtct cc                        1302


<210>  46
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  46
gagtactgtg agagcaagta g                                                 21


<210>  47
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  47
gccgcagcct gtagcaagct c                                                 21


<210>  48
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  48
gcggccgcta gcgcgatcgc g                                                 21


<210>  49
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  49
gacgccccgc gatcgcgcta g                                                 21


<210>  50
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  50
gtggcgagtg ggtgagtgag g                                                 21


<210>  51
<211>  26
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  51
acaccgctct cacagtactc gctgag                                            26


<210>  52
<211>  27
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  52
acaccgccgc agcctgtagc aagctcg                                           27


<210>  53
<211>  27
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  53
acaccgagta ctgtgagagc aagtagg                                           27


<210>  54
<211>  27
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  54
acaccgacgc cccgcgatcg cgctagg                                           27


<210>  55
<211>  27
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  55
acaccgcggc cgctagcgcg atcgcgg                                           27


<210>  56
<211>  27
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  56
acaccgtggc gagtgggtga gtgaggg                                           27


<210>  57
<211>  26
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  57
acaccggaag aggcgcgggt agaagg                                            26


<210>  58
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  58
gacgcgttaa tgccaacttt                                                   20


<210>  59
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  59
gagggcctat ttcccatgat                                                   20


<210>  60
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  60
gacgcgttaa tgccaacttt                                                   20


<210>  61
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  61
gaacttacgg agtcccacga                                                   20


<210>  62
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  62
ggagacagct cgggtactga                                                   20


<210>  63
<211>  82
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  63
gttggaacca ttcaaaacag catagcaagt taaaataagg ctagtccgtt atcaacttga       60

aaaagtggca ccgagtcggt gc                                                82


<210>  64
<211>  76
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  64
gttttagagc tagaaatagc aagttaaaat aaggctagtc cgttatcaac ttgaaaaagt       60

ggcaccgagt cggtgc                                                       76


<210>  65
<211>  86
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  65
gtttaagagc tatgctggaa acagcatagc aagtttaaat aaggctagtc cgttatcaac       60

ttgaaaaagt ggcaccgagt cggtgc                                            86


<210>  66
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Forward Primer

<400>  66
catcccaatt gccctttcc                                                    19


<210>  67
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Reverse Primer

<400>  67
cccacacctg ctcttgctag a                                                 21


<210>  68
<211>  17
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Probe

<400>  68
tctaggtgga aagtggg                                                      17


<210>  69
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Forward Primer

<400>  69
gagcaggtgt gggtttagga                                                   20


<210>  70
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Reverse Primer

<400>  70
ccaggtctca ctgcattcca                                                   20


<210>  71
<211>  26
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Probe

<400>  71
attgcaagcg ttcggataat gtgaga                                            26


<210>  72
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Forward Primer

<400>  72
gctgtcacga aggctttctt c                                                 21


<210>  73
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Reverse Primer

<400>  73
gcactgctgc caactacaac                                                   20


<210>  74
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Probe

<400>  74
tcaatgccat cagctcacac ctgc                                              24


<210>  75
<211>  17
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Forward Primer

<400>  75
aagaggcgcg ggtagaa                                                      17


<210>  76
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Reverse Primer

<400>  76
cagcttcggt cagagaaatg ag                                                22


<210>  77
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Probe

<400>  77
ctctcctcag agctcgacgc attt                                              24


<210>  78
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Forward Primer

<400>  78
ctgcacaatt tcagcccaag                                                   20


<210>  79
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Reverse Primer

<400>  79
caggtcatgt cccacagaat                                                   20


<210>  80
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Probe

<400>  80
catatgaggg cagcaatgca agtc                                              24


<210>  81
<211>  16
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LNA Probe for sense G4C2 RNA


<220>
<221>  TYE563
<222>  (1)..(1)

<400>  81
ccccggcccc ggcccc                                                       16


<210>  82
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LNA Probe for antisense G4C2 RNA


<220>
<221>  TYE563
<222>  (1)..(1)

<400>  82
ggggccgggg ccggggggcc cc                                                22


<210>  83
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  DNA Probe for sense G4C2 RNA


<220>
<221>  Cy3
<222>  (18)..(18)

<400>  83
ccccggcccc ggccccgg                                                     18


<210>  84
<211>  17
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  DNA Probe for antisense G4C2 RNA


<220>
<221>  Cy3
<222>  (17)..(17)

<400>  84
ggggccgggg ccggggc                                                      17


