
                                SEQUENCE LISTING

<110> Mendoza, Juan Luis
      Garcia, Kenan Christopher

<120> VARIANT TYPE III INTERFERONS AND
  SYNTHEKINES

<130> STAN-1335WO

<140> PCT/US2017/054498
<141> 2017-09-29

<150>   62/402,204        
<151> 2016-09-30  

<160> 23

<170> FastSEQ for Windows Version 4.0

<210> 1
<211> 169
<212> PRT
<213> Homo sapiens

<400> 1
Pro Thr Ser Lys Pro Thr Thr Thr Gly Lys Gly Cys His Ile Gly Arg
 1               5                  10                  15      
Phe Lys Ser Leu Ser Pro Gln Glu Leu Ala Ser Phe Lys Lys Ala Arg
            20                  25                  30          
Asp Ala Leu Glu Glu Ser Leu Lys Leu Lys Asn Trp Ser Cys Ser Ser
        35                  40                  45              
Pro Val Phe Pro Gly Asn Trp Asp Leu Arg Leu Leu Gln Val Arg Glu
    50                  55                  60                  
Arg Pro Val Ala Leu Glu Ala Glu Leu Ala Leu Thr Leu Lys Val Leu
65                  70                  75                  80  
Glu Ala Ala Ala Gly Pro Ala Leu Glu Asp Val Leu Asp Gln Pro Leu
                85                  90                  95      
His Thr Leu His His Ile Leu Ser Gln Leu Gln Ala Cys Ile Gln Pro
            100                 105                 110         
Gln Pro Thr Ala Gly Pro Arg Pro Arg Gly Arg Leu His His Trp Leu
        115                 120                 125             
His Arg Leu Gln Glu Ala Pro Lys Lys Glu Ser Ala Gly Cys Leu Glu
    130                 135                 140                 
Ala Ser Val Thr Phe Asn Leu Phe Arg Leu Leu Thr Arg Asp Leu Lys
145                 150                 155                 160 
Tyr Val Ala Asp Gly Asn Leu Cys Leu
                165                 


<210> 2
<211> 174
<212> PRT
<213> Homo sapiens

<400> 2
Pro Val Ala Arg Leu His Gly Ala Leu Pro Asp Ala Arg Gly Cys His
 1               5                  10                  15      
Ile Ala Gln Phe Lys Ser Leu Ser Pro Gln Glu Leu Gln Ala Phe Lys
            20                  25                  30          
Arg Ala Lys Asp Ala Leu Glu Glu Ser Leu Leu Leu Lys Asp Cys Arg
        35                  40                  45              
Cys His Ser Arg Leu Phe Pro Arg Thr Trp Asp Leu Arg Gln Leu Gln
    50                  55                  60                  
Val Arg Glu Arg Pro Met Ala Leu Glu Ala Glu Leu Ala Leu Thr Leu
65                  70                  75                  80  
Lys Val Leu Glu Ala Thr Ala Asp Thr Asp Pro Ala Leu Val Asp Val
                85                  90                  95      
Leu Asp Gln Pro Leu His Thr Leu His His Ile Leu Ser Gln Phe Arg
            100                 105                 110         
Ala Cys Ile Gln Pro Gln Pro Thr Ala Gly Pro Arg Thr Arg Gly Arg
        115                 120                 125             
Leu His His Trp Leu Tyr Arg Leu Gln Glu Ala Pro Lys Lys Glu Ser
    130                 135                 140                 
Pro Gly Cys Leu Glu Ala Ser Val Thr Phe Asn Leu Phe Arg Leu Leu
145                 150                 155                 160 
Thr Arg Asp Leu Asn Cys Val Ala Ser Gly Asp Leu Cys Val
                165                 170                 


<210> 3
<211> 174
<212> PRT
<213> Homo sapiens

<400> 3
Pro Val Ala Arg Leu Arg Gly Ala Leu Pro Asp Ala Arg Gly Cys His
 1               5                  10                  15      
Ile Ala Gln Phe Lys Ser Leu Ser Pro Gln Glu Leu Gln Ala Phe Lys
            20                  25                  30          
Arg Ala Lys Asp Ala Leu Glu Glu Ser Leu Leu Leu Lys Asp Cys Lys
        35                  40                  45              
Cys Arg Ser Arg Leu Phe Pro Arg Thr Trp Asp Leu Arg Gln Leu Gln
    50                  55                  60                  
Val Arg Glu Arg Pro Val Ala Leu Glu Ala Glu Leu Ala Leu Thr Leu
65                  70                  75                  80  
Lys Val Leu Glu Ala Thr Ala Asp Thr Asp Pro Ala Leu Gly Asp Val
                85                  90                  95      
Leu Asp Gln Pro Leu His Thr Leu His His Ile Leu Ser Gln Leu Arg
            100                 105                 110         
Ala Cys Ile Gln Pro Gln Pro Thr Ala Gly Pro Arg Thr Arg Gly Arg
        115                 120                 125             
Leu His His Trp Leu His Arg Leu Gln Glu Ala Pro Lys Lys Glu Ser
    130                 135                 140                 
Pro Gly Cys Leu Glu Ala Ser Val Thr Phe Asn Leu Phe Arg Leu Leu
145                 150                 155                 160 
Thr Arg Asp Leu Asn Cys Val Ala Ser Gly Asp Leu Cys Val
                165                 170                 


<210> 4
<211> 156
<212> PRT
<213> Homo sapiens

<400> 4
Pro Arg Arg Cys Leu Leu Ser His Tyr Arg Ser Leu Glu Pro Arg Thr
 1               5                  10                  15      
Leu Ala Ala Ala Lys Ala Leu Arg Asp Arg Tyr Glu Glu Glu Ala Leu
            20                  25                  30          
Ser Trp Gly Gln Arg Asn Cys Ser Phe Arg Pro Arg Arg Asp Pro Pro
        35                  40                  45              
Arg Pro Ser Ser Cys Ala Arg Leu Arg His Val Ala Arg Gly Ile Ala
    50                  55                  60                  
Asp Ala Gln Ala Val Leu Ser Gly Leu His Arg Ser Glu Leu Leu Pro
65                  70                  75                  80  
Gly Ala Gly Pro Ile Leu Glu Leu Leu Ala Ala Ala Gly Arg Asp Val
                85                  90                  95      
Ala Ala Cys Leu Glu Leu Ala Arg Pro Gly Ser Ser Arg Lys Val Pro
            100                 105                 110         
Gly Ala Gln Lys Arg Arg His Lys Pro Arg Arg Ala Asp Ser Pro Arg
        115                 120                 125             
Cys Arg Lys Ala Ser Val Val Phe Asn Leu Leu Arg Leu Leu Thr Trp
    130                 135                 140                 
Glu Leu Arg Leu Ala Ala His Ser Gly Pro Cys Leu
145                 150                 155     


<210> 5
<211> 173
<212> PRT
<213> Mus musculus

<400> 5
Pro Val Pro Arg Ala Thr Arg Leu Pro Val Glu Ala Lys Asp Cys His
 1               5                  10                  15      
Ile Ala Gln Phe Lys Ser Leu Ser Pro Lys Glu Leu Gln Ala Phe Lys
            20                  25                  30          
Lys Ala Lys Gly Ala Ile Glu Lys Arg Leu Leu Glu Lys Asp Met Arg
        35                  40                  45              
Cys Ser Ser His Leu Ile Ser Arg Ala Trp Asp Leu Lys Gln Leu Gln
    50                  55                  60                  
Val Gln Glu Arg Pro Lys Ala Leu Gln Ala Glu Val Ala Leu Thr Leu
65                  70                  75                  80  
Lys Val Trp Glu Asn Ile Asn Asp Ser Ala Leu Thr Thr Ile Leu Gly
                85                  90                  95      
Gln Pro Leu His Thr Leu Ser His Ile His Ser Gln Leu Gln Thr Cys
            100                 105                 110         
Thr Gln Leu Gln Ala Thr Ala Glu Pro Lys Pro Pro Ser Arg Arg Leu
        115                 120                 125             
Ser Arg Trp Leu His Arg Leu Gln Glu Ala Gln Ser Lys Glu Thr Pro
    130                 135                 140                 
Gly Cys Leu Glu Asp Ser Val Thr Ser Asn Leu Phe Gln Leu Leu Leu
145                 150                 155                 160 
Arg Asp Leu Lys Cys Val Ala Ser Gly Asp Gln Cys Val
                165                 170             


<210> 6
<211> 173
<212> PRT
<213> Mus musculus

<400> 6
Pro Val Pro Arg Ala Thr Arg Leu Pro Val Glu Ala Lys Asp Cys His
 1               5                  10                  15      
Ile Ala Gln Phe Lys Ser Leu Ser Pro Lys Glu Leu Gln Ala Phe Lys
            20                  25                  30          
Lys Ala Lys Asp Ala Ile Glu Lys Arg Leu Leu Glu Lys Asp Leu Arg
        35                  40                  45              
Cys Ser Ser His Leu Phe Pro Arg Ala Trp Asp Leu Lys Gln Leu Gln
    50                  55                  60                  
Val Gln Glu Arg Pro Lys Ala Leu Gln Ala Glu Val Ala Leu Thr Leu
65                  70                  75                  80  
Lys Val Trp Glu Asn Met Thr Asp Ser Ala Leu Ala Thr Ile Leu Gly
                85                  90                  95      
Gln Pro Leu His Thr Leu Ser His Ile His Ser Gln Leu Gln Thr Cys
            100                 105                 110         
Thr Gln Leu Gln Ala Thr Ala Glu Pro Arg Ser Pro Ser Arg Arg Leu
        115                 120                 125             
Ser Arg Trp Leu His Arg Leu Gln Glu Ala Gln Ser Lys Glu Thr Pro
    130                 135                 140                 
Gly Cys Leu Glu Ala Ser Val Thr Ser Asn Leu Phe Arg Leu Leu Thr
145                 150                 155                 160 
Arg Asp Leu Lys Cys Val Ala Asn Gly Asp Gln Cys Val
                165                 170             


<210> 7
<211> 174
<212> PRT
<213> Homo sapiens

<400> 7
Pro Val Ala Gly Leu Gly Gly Ala Leu Pro Asp Ala Arg Gly Cys His
 1               5                  10                  15      
Ile Ala Gln Phe Lys Ser Leu Ser Pro Gln Glu Leu Gln Ala Phe Lys
            20                  25                  30          
Arg Ala Lys Asp Ala Leu Glu Glu Ser Leu Leu Leu Lys Asp Cys Lys
        35                  40                  45              
Cys Arg Ser Arg Leu Phe Pro Arg Thr Trp Asp Leu Arg Gln Leu Gln
    50                  55                  60                  
Val Arg Glu Arg Pro Val Ala Leu Glu Ala Glu Leu Ala Leu Thr Leu
65                  70                  75                  80  
Lys Val Leu Asp Ala Thr Ala Asp Thr Asp Pro Ala Leu Gly Asp Val
                85                  90                  95      
Leu Asp Gln Pro Leu His Thr Leu His His Ile Leu Ser Gln Leu Arg
            100                 105                 110         
Ala Cys Ile Gln Pro Gln Pro Thr Ala Gly Pro Arg Thr Arg Gly Arg
        115                 120                 125             
Leu His Arg Trp Leu His Arg Leu Gln Glu Ala Pro Lys Lys Glu Ser
    130                 135                 140                 
Pro Gly Cys Leu Glu Ala Ser Val Thr Phe Asn Leu Phe Arg Leu Leu
145                 150                 155                 160 
Thr Arg Asp Leu Asn Cys Val Ala Ser Gly Asp Leu Cys Glu
                165                 170                 


<210> 8
<211> 174
<212> PRT
<213> Homo sapiens


<220>
<221>  misc_feature
<222>  (174)..(174)
<223>  Xaa can be any naturally occurring amino acid

<400> 8
Pro Val Ala Arg Leu Gly Gly Ala Leu Pro Asp Ala Arg Gly Cys His
 1               5                  10                  15      
Ile Ala Gln Phe Lys Ser Leu Tyr Pro Gln Glu Leu Gln Ala Phe Lys
            20                  25                  30          
Arg Ala Lys Asp Ala Leu Glu Glu Ser Leu Leu Leu Lys Asp Cys Lys
        35                  40                  45              
Cys Arg Ser Arg Leu Phe Pro Arg Thr Trp Asp Leu Arg Gln Leu Gln
    50                  55                  60                  
Val Arg Glu Arg Pro Val Ala Leu Glu Ala Glu Leu Ala Leu Thr Leu
65                  70                  75                  80  
Lys Val Leu Glu Ala Thr Ala Asp Thr Asp Pro Ala Leu Gly Asp Val
                85                  90                  95      
Leu Asp Gln Pro Leu His Thr Leu Leu His Ile Leu Ser Gln Leu Arg
            100                 105                 110         
Ala Cys Ile Gln Pro Gln Pro Thr Ala Gly Pro Arg Thr Arg Gly Arg
        115                 120                 125             
Leu His His Trp Leu His Arg Leu Gln Glu Ala Pro Lys Lys Glu Ser
    130                 135                 140                 
Pro Gly Cys Leu Glu Ala Ser Val Thr Phe Asn Leu Phe Arg Leu Leu
145                 150                 155                 160 
Thr Arg Asp Leu Asn Cys Val Ala Ser Gly Asp Val Cys Xaa
                165                 170                 


<210> 9
<211> 174
<212> PRT
<213> Homo sapiens

<400> 9
Pro Val Ala Arg Leu Thr Gly Ala Leu Pro Val Ala Arg Gly Cys His
 1               5                  10                  15      
Ile Ala Gln Phe Lys Ser Leu Ser Pro Gln Glu Leu Gln Ala Phe Lys
            20                  25                  30          
Arg Ala Lys Asp Ala Leu Glu Glu Ser Leu Leu Leu Lys Asp Cys Lys
        35                  40                  45              
Cys Arg Ser Arg Leu Phe Pro Arg Thr Trp Asp Leu Arg Gln Leu Gln
    50                  55                  60                  
Val Arg Glu Arg Pro Val Ala Leu Glu Ala Glu Leu Ala Leu Thr Leu
65                  70                  75                  80  
Lys Val Leu Asp Ala Thr Ala Asp Thr Asp Pro Ala Leu Gly Asp Val
                85                  90                  95      
Leu Asp Gln Pro Leu His Thr Leu His His Ile Leu Ser Gln Leu Arg
            100                 105                 110         
Ala Cys Ile Gln Pro Gln Pro Thr Ala Gly Pro Arg Thr Arg Gly Arg
        115                 120                 125             
Leu His His Trp Leu His Arg Leu Gln Glu Ala Pro Lys Lys Glu Ser
    130                 135                 140                 
Pro Gly Cys Leu Glu Ala Ser Val Thr Phe Asn Leu Phe Arg Leu Leu
145                 150                 155                 160 
Ile Arg Asp Leu Asn Cys Val Ala Ser Gly Asp Leu Cys Val
                165                 170                 


<210> 10
<211> 173
<212> PRT
<213> Homo sapiens

<400> 10
Pro Val Ala Gly Leu Ser Gly Ala Leu Pro Asp Ala Arg Gly Cys His
 1               5                  10                  15      
Ile Ala Gln Phe Lys Ser Leu Phe Pro Gln Glu Val Gln Ala Phe Lys
            20                  25                  30          
Arg Ala Lys Asp Ala Leu Glu Glu Ser Leu Leu Leu Lys Asp Cys Lys
        35                  40                  45              
Cys Arg Ser Arg Leu Phe Pro Arg Thr Trp Asp Leu Arg Gln Leu Gln
    50                  55                  60                  
Val Arg Glu Arg Pro Val Ala Leu Glu Ala Glu Leu Ala Leu Thr Leu
65                  70                  75                  80  
Lys Val Leu Asp Ala Thr Ala Asp Thr Asp Pro Ala Leu Gly Asp Val
                85                  90                  95      
Leu Asp Gln Pro Leu His Thr Leu His Tyr Ile Leu Ser Gln Leu Arg
            100                 105                 110         
Ala Cys Ile Gln Pro Gln Pro Thr Ala Gly Pro Arg Thr Arg Gly Arg
        115                 120                 125             
Leu His His Trp Leu His Arg Leu Gln Glu Ala Pro Lys Lys Glu Ser
    130                 135                 140                 
Pro Gly Cys Leu Glu Ala Ser Val Thr Phe Asn Leu Phe Arg Leu Leu
145                 150                 155                 160 
Thr Arg Asp Leu Asn Cys Val Ala Ser Gly Asp Leu Glu
                165                 170             


<210> 11
<211> 174
<212> PRT
<213> Homo sapiens

<400> 11
Pro Val Ala Arg Leu Ser Gly Ala Leu Pro Asp Ala Arg Gly Cys His
 1               5                  10                  15      
Ile Ala Gln Phe Lys Ser Leu Phe Pro Gln Glu Val Gln Ala Phe Lys
            20                  25                  30          
Arg Ala Lys Asp Ala Leu Glu Glu Ser Leu Leu Leu Lys Asp Cys Lys
        35                  40                  45              
Cys Arg Ser Arg Leu Phe Pro Arg Thr Trp Asp Leu Arg Gln Leu Gln
    50                  55                  60                  
Val Arg Glu Arg Pro Val Ala Leu Glu Ala Glu Leu Ala Leu Thr Leu
65                  70                  75                  80  
Lys Val Leu Glu Ala Thr Ala Asp Thr Asp Pro Ala Leu Gly Asp Val
                85                  90                  95      
Leu Asp Gln Pro Leu His Thr Leu His His Ile Leu Ser Gln Leu Arg
            100                 105                 110         
Ala Cys Ile Gln Pro Gln Pro Thr Ala Gly Pro Arg Thr Arg Gly Arg
        115                 120                 125             
Leu His His Trp Leu His Arg Leu Gln Glu Ala Pro Lys Lys Glu Ser
    130                 135                 140                 
Pro Gly Cys Leu Glu Ala Ser Val Thr Phe Asn Leu Phe Arg Leu Leu
145                 150                 155                 160 
Thr Arg Asp Leu Asn Cys Val Ala Ser Gly Asp Leu Cys Glu
                165                 170                 


<210> 12
<211> 174
<212> PRT
<213> Homo sapiens

<400> 12
Pro Asp Ala Arg Leu Arg Gly Ala Leu Pro Asp Ala Arg Gly Cys His
 1               5                  10                  15      
Ile Ala Gln Phe Lys Ser Leu Ser Pro Arg Glu Leu Gln Ala Phe Lys
            20                  25                  30          
Arg Ala Lys Asp Ala Leu Glu Glu Ser Leu Leu Leu Lys Asp Cys Lys
        35                  40                  45              
Cys Arg Ser Arg Leu Phe Pro Arg Thr Trp Asp Leu Arg Gln Leu Gln
    50                  55                  60                  
Val Arg Glu Arg Pro Val Ala Leu Glu Ala Glu Leu Ala Leu Thr Leu
65                  70                  75                  80  
Lys Val Leu Glu Ala Thr Ala Asp Thr Asp Pro Ala Leu Gly Asp Val
                85                  90                  95      
Leu Asp Gln Pro Leu His Thr Leu His His Ile Leu Ser Gln Leu Arg
            100                 105                 110         
Ala Cys Ile Gln Pro Gln Pro Thr Ala Gly Pro Arg Thr Arg Gly Arg
        115                 120                 125             
Leu His Arg Trp Leu His Arg Leu Gln Glu Ala Pro Lys Lys Glu Ser
    130                 135                 140                 
Pro Gly Cys Leu Glu Ala Ser Val Thr Phe Asn Leu Phe Arg Leu Leu
145                 150                 155                 160 
Ala Arg Asp Leu Asn Cys Val Ala Ser Gly Asp Leu Cys Glu
                165                 170                 


<210> 13
<211> 175
<212> PRT
<213> Homo sapiens

<400> 13
Pro Val Ala Arg Leu Ser Gly Ala Leu Pro Asp Ala Arg Gly Cys His
 1               5                  10                  15      
Ile Ala Gln Phe Lys Ser Leu Ser Pro Arg Glu Leu Gln Ala Phe Lys
            20                  25                  30          
Arg Ala Lys Asp Ala Leu Lys Glu Ser Leu Leu Leu Lys Asp Cys Lys
        35                  40                  45              
Cys Arg Ser Arg Leu Phe Pro Arg Thr Trp Asp Leu Arg Gln Leu Gln
    50                  55                  60                  
Val Arg Glu Arg Pro Val Ala Leu Glu Ala Glu Leu Ala Leu Thr Leu
65                  70                  75                  80  
Lys Val Leu Glu Ala Thr Ala Asp Thr Asp Pro Ala Leu Gly Asp Val
                85                  90                  95      
Leu Asp Gln Pro Leu His Thr Leu His His Ile Leu Ser Gln Leu Arg
            100                 105                 110         
Ala Cys Ile Gln Pro Gln Pro Thr Ala Gly Pro Arg Thr Arg Gly Arg
        115                 120                 125             
Leu His Arg Trp Leu His Arg Leu Gln Glu Ala Pro Lys Lys Glu Ser
    130                 135                 140                 
Pro Gly Cys Leu Glu Ala Ser Val Thr Phe Asn Leu Phe Arg Leu Leu
145                 150                 155                 160 
Ala Arg Asp Leu Asn Cys Val Ala Ser Gly Asp Leu Cys Glu Ala
                165                 170                 175 


<210> 14
<211> 175
<212> PRT
<213> Homo sapiens

<400> 14
Pro Ala Ala Arg Leu Arg Gly Ala Leu Pro Asp Ala Arg Gly Cys His
 1               5                  10                  15      
Ile Ala Gln Phe Lys Ser Leu Ser Pro Arg Glu Leu Gln Ala Phe Lys
            20                  25                  30          
Arg Ala Lys Asp Ala Leu Glu Glu Ser Leu Leu Leu Lys Asp Cys Lys
        35                  40                  45              
Cys Arg Ser Arg Leu Phe Pro Arg Thr Trp Asp Leu Arg Gln Leu Gln
    50                  55                  60                  
Val Arg Glu Arg Pro Val Ala Leu Glu Ala Glu Leu Ala Leu Thr Leu
65                  70                  75                  80  
Lys Val Leu Asp Ala Thr Ala Asp Thr Asp Pro Ala Leu Gly Asp Val
                85                  90                  95      
Leu Asp Gln Pro Leu His Thr Leu His His Ile Leu Ser Gln Leu Arg
            100                 105                 110         
Ala Cys Ile Gln Pro Gln Pro Thr Ala Gly Pro Arg Thr Arg Gly Arg
        115                 120                 125             
Leu His Arg Trp Leu His Arg Leu Gln Glu Ala Pro Lys Lys Glu Ser
    130                 135                 140                 
Pro Gly Cys Leu Glu Ala Ser Val Thr Phe Asn Leu Phe Arg Leu Leu
145                 150                 155                 160 
Ile Arg Asp Leu Asn Cys Val Ala Ser Gly Asp Leu Cys Asp Ala
                165                 170                 175 


<210> 15
<211> 174
<212> PRT
<213> Homo sapiens

<400> 15
Pro Ala Ala Arg Leu Arg Gly Ala Leu Pro Asp Ala Arg Gly Cys His
 1               5                  10                  15      
Ile Ala Gln Phe Lys Ser Leu Ser Pro Arg Glu Leu Gln Ala Phe Lys
            20                  25                  30          
Arg Ala Lys Asp Ala Leu Glu Glu Ser Leu Leu Leu Lys Asp Cys Lys
        35                  40                  45              
Cys Arg Ser Arg Leu Phe Pro Arg Thr Trp Asp Leu Arg Gln Leu Gln
    50                  55                  60                  
Val Arg Glu Arg Pro Val Ala Leu Glu Ala Glu Leu Ala Leu Thr Leu
65                  70                  75                  80  
Lys Val Leu Asp Ala Thr Ala Asp Thr Asp Pro Ala Leu Gly Asp Val
                85                  90                  95      
Leu Asp Gln Pro Leu His Thr Leu His His Ile Leu Ser Gln Leu Arg
            100                 105                 110         
Ala Cys Ile Gln Pro Gln Pro Thr Ala Gly Pro Arg Thr Arg Gly Arg
        115                 120                 125             
Leu His Arg Trp Leu His Arg Leu Gln Glu Ala Pro Lys Lys Glu Ser
    130                 135                 140                 
Pro Gly Cys Leu Glu Ala Ser Val Thr Phe Asn Leu Phe Arg Leu Leu
145                 150                 155                 160 
Thr Arg Asp Leu Asn Cys Val Ala Ser Gly Tyr Leu Cys Glu
                165                 170                 


<210> 16
<211> 175
<212> PRT
<213> Homo sapiens

<400> 16
Pro Ala Ala Arg Leu Arg Gly Ala Leu Pro Asp Ala Arg Gly Cys His
 1               5                  10                  15      
Ile Ala Gln Phe Lys Ser Leu Ser Pro Arg Glu Leu Gln Ala Phe Lys
            20                  25                  30          
Arg Ala Lys Asp Ala Leu Glu Glu Ser Leu Leu Leu Lys Asp Cys Lys
        35                  40                  45              
Cys Arg Ser Arg Leu Phe Pro Arg Thr Trp Asp Leu Arg Gln Leu Gln
    50                  55                  60                  
Val Arg Glu Arg Pro Val Ala Leu Glu Ala Glu Leu Ala Leu Thr Leu
65                  70                  75                  80  
Lys Val Leu Glu Ala Thr Ala Asp Thr Asp Pro Ala Leu Gly Asp Val
                85                  90                  95      
Leu Asp Gln Pro Leu His Thr Leu Leu His Ile Leu Ser Gln Leu Arg
            100                 105                 110         
Ala Cys Ile Gln Pro Gln Pro Thr Ala Gly Pro Arg Thr Arg Gly Arg
        115                 120                 125             
Leu His His Trp Leu His Arg Leu Gln Glu Ala Pro Lys Lys Glu Ser
    130                 135                 140                 
Pro Gly Cys Leu Glu Ala Ser Val Thr Tyr Asn Leu Phe Arg Leu Leu
145                 150                 155                 160 
Ala Arg Asp Leu Asn Cys Val Ala Ser Gly Asp Leu Cys Glu Ala
                165                 170                 175 


<210> 17
<211> 175
<212> PRT
<213> Homo sapiens

<400> 17
Pro Val Ala Arg Leu Ser Gly Ala Leu Pro Asp Ala Arg Gly Cys His
 1               5                  10                  15      
Ile Ala Gln Phe Lys Ser Leu Ser Pro Arg Glu Leu Gln Ala Phe Lys
            20                  25                  30          
Arg Ala Lys Asp Ala Leu Glu Glu Ser Leu Leu Leu Lys Asp Cys Lys
        35                  40                  45              
Cys Arg Ser Arg Leu Phe Pro Arg Thr Trp Asp Leu Arg Gln Leu Gln
    50                  55                  60                  
Val Arg Glu Arg Pro Val Ala Leu Glu Ala Glu Leu Ala Leu Thr Leu
65                  70                  75                  80  
Lys Val Leu Glu Ala Thr Ala Asp Thr Asp Pro Ala Leu Gly Asp Val
                85                  90                  95      
Leu Asp Gln Pro Leu His Thr Leu Leu His Ile Leu Ser Gln Leu Arg
            100                 105                 110         
Ala Cys Ile Gln Pro Gln Pro Thr Ala Gly Pro Arg Thr Arg Gly Arg
        115                 120                 125             
Leu His His Trp Leu His Arg Leu Gln Glu Ala Pro Lys Lys Glu Ser
    130                 135                 140                 
Pro Gly Cys Leu Glu Ala Ser Val Thr Tyr Asn Leu Phe Arg Leu Leu
145                 150                 155                 160 
Ala Arg Asp Leu Asn Cys Val Ala Ser Gly Asp Leu Cys Glu Ala
                165                 170                 175 


<210> 18
<211> 174
<212> PRT
<213> Homo sapiens

<400> 18
Pro Val Ala Arg Leu Ser Gly Ala Leu Pro Asp Ala Arg Gly Cys His
 1               5                  10                  15      
Ile Ala Gln Phe Lys Ser Leu Ser Pro Gln Glu Leu Gln Ala Phe Lys
            20                  25                  30          
Arg Ala Lys Asp Ala Leu Glu Glu Ser Leu Leu Leu Lys Asp Cys Lys
        35                  40                  45              
Cys Arg Ser Arg Leu Phe Pro Arg Thr Trp Asp Leu Arg Gln Leu Gln
    50                  55                  60                  
Val Arg Glu Arg Pro Val Ala Leu Glu Ala Glu Leu Ala Leu Thr Leu
65                  70                  75                  80  
Lys Val Leu Glu Ala Thr Ala Asp Thr Asp Pro Ala Leu Gly Asp Val
                85                  90                  95      
Leu Asp Gln Pro Leu His Thr Leu Leu His Ile Leu Ser Gln Leu Arg
            100                 105                 110         
Ala Cys Ile Gln Pro Gln Pro Thr Ala Gly Pro Arg Thr Arg Gly Arg
        115                 120                 125             
Leu His His Trp Leu His Arg Leu Gln Glu Ala Pro Lys Lys Glu Ser
    130                 135                 140                 
Pro Gly Cys Leu Glu Ala Ser Val Thr Tyr Asn Leu Phe Arg Leu Leu
145                 150                 155                 160 
Ala Arg Asp Leu Asn Cys Val Ala Ser Gly Asp Leu Cys Glu
                165                 170                 


<210> 19
<211> 175
<212> PRT
<213> Homo sapiens

<400> 19
Pro Val Ala Gly Leu Arg Gly Ala Leu Pro Asp Ala Arg Gly Cys His
 1               5                  10                  15      
Ile Ala Gln Phe Lys Ser Leu Ser Pro Arg Glu Leu Gln Ala Phe Lys
            20                  25                  30          
Arg Ala Lys Asp Ala Leu Glu Glu Ser Leu Leu Leu Lys Asp Cys Lys
        35                  40                  45              
Cys Arg Ser Arg Leu Phe Pro Arg Thr Trp Asp Leu Arg Gln Leu Gln
    50                  55                  60                  
Val Arg Glu Arg Pro Val Ala Leu Glu Ala Glu Leu Ala Leu Thr Leu
65                  70                  75                  80  
Lys Val Leu Asp Ala Thr Ala Asp Thr Asp Pro Ala Leu Gly Asp Val
                85                  90                  95      
Leu Asp Gln Pro Leu His Thr Leu His His Ile Leu Ser Gln Leu Arg
            100                 105                 110         
Ala Cys Ile Gln Pro Gln Pro Thr Ala Gly Pro Arg Thr Arg Gly Arg
        115                 120                 125             
Leu His Arg Trp Leu His Arg Leu Gln Glu Ala Pro Lys Lys Glu Ser
    130                 135                 140                 
Pro Gly Cys Leu Glu Ala Ser Val Thr Phe Asn Leu Phe Arg Leu Leu
145                 150                 155                 160 
Ala Arg Asp Leu Asn Cys Val Ala Ser Gly Asp Leu Cys Glu Ala
                165                 170                 175 


<210> 20
<211> 163
<212> PRT
<213> Homo sapiens

<400> 20
Ala Arg Gly Cys His Ile Ala Gln Phe Lys Ser Leu Ser Pro Ala Glu
 1               5                  10                  15      
Leu Gln Ala Phe Lys Arg Ala Lys Asp Ala Leu Glu Glu Ser Leu Leu
            20                  25                  30          
Leu Lys Asp Cys Lys Cys Arg Ser Arg Leu Phe Pro Arg Thr Trp Asp
        35                  40                  45              
Leu Arg Gln Leu Gln Val Arg Glu Arg Pro Val Ala Leu Glu Ala Glu
    50                  55                  60                  
Leu Ala Leu Thr Leu Lys Val Leu Glu Ala Thr Ala Asp Thr Asp Pro
65                  70                  75                  80  
Ala Leu Gly Asp Val Leu Asp Ala Pro Leu Ala Thr Leu His His Ile
                85                  90                  95      
Leu Ser Gln Leu Arg Ala Cys Ile Gln Pro Gln Pro Thr Ala Gly Pro
            100                 105                 110         
Arg Thr Arg Gly Arg Leu His Arg Trp Leu His Arg Leu Gln Glu Ala
        115                 120                 125             
Pro Lys Lys Glu Ser Pro Gly Cys Leu Glu Ala Ser Val Thr Phe Asn
    130                 135                 140                 
Leu Phe Arg Leu Leu Ala Arg Asp Leu Asn Cys Val Ala Ser Gly Asp
145                 150                 155                 160 
Leu Cys Glu
            


<210> 21
<211> 174
<212> PRT
<213> Homo sapiens

<400> 21
Leu Gly Cys Asp Leu Pro Gln Asn His Gly Leu Leu Ser Arg Asn Thr
 1               5                  10                  15      
Leu Val Leu Leu His Gln Met Arg Arg Ile Ser Pro Phe Leu Cys Leu
            20                  25                  30          
Lys Asp Arg Arg Asp Phe Arg Phe Pro Gln Glu Met Val Lys Gly Ser
        35                  40                  45              
Gln Leu Gln Lys Ala His Val Met Ser Val Leu His Glu Met Leu Gln
    50                  55                  60                  
Gln Ile Phe Ser Leu Phe His Thr Glu Arg Ser Ser Ala Ala Trp Asn
65                  70                  75                  80  
Met Thr Leu Leu Asp Gln Leu His Thr Gly Leu His Gln Gln Leu Gln
                85                  90                  95      
His Leu Glu Thr Cys Leu Leu Gln Val Val Gly Glu Gly Glu Ser Ala
            100                 105                 110         
Gly Ala Ile Ser Ser Pro Ala Leu Thr Leu Arg Arg Tyr Phe Gln Gly
        115                 120                 125             
Ile Arg Val Tyr Leu Lys Glu Lys Lys Tyr Ser Asp Cys Ala Trp Glu
    130                 135                 140                 
Val Val Arg Met Glu Ile Met Lys Ser Leu Phe Leu Ser Thr Asn Met
145                 150                 155                 160 
Gln Glu Arg Leu Arg Ser Lys Asp Arg Asp Leu Gly Ser Ser
                165                 170                 


<210> 22
<211> 174
<212> PRT
<213> Homo sapiens

<400> 22
Leu Gly Cys Asp Leu Pro Gln Asn His Gly Leu Leu Ser Ala Asn Thr
 1               5                  10                  15      
Leu Val Leu Leu His Gln Met Arg Arg Ile Ser Pro Phe Leu Cys Ala
            20                  25                  30          
Lys Asp Ala Arg Asp Phe Arg Phe Pro Gln Glu Met Val Lys Gly Ser
        35                  40                  45              
Gln Leu Gln Lys Ala His Val Met Ser Val Leu His Glu Met Leu Gln
    50                  55                  60                  
Gln Ile Phe Ser Leu Phe His Thr Glu Arg Ser Ser Ala Ala Trp Asn
65                  70                  75                  80  
Met Thr Leu Leu Asp Gln Leu His Thr Gly Leu His Gln Gln Leu Gln
                85                  90                  95      
His Leu Glu Thr Cys Leu Leu Gln Val Val Gly Glu Gly Glu Ser Ala
            100                 105                 110         
Gly Ala Ile Ser Ser Pro Ala Leu Thr Leu Arg Arg Tyr Phe Gln Gly
        115                 120                 125             
Ile Arg Val Tyr Leu Lys Glu Lys Lys Tyr Ser Asp Cys Ala Trp Glu
    130                 135                 140                 
Val Val Arg Met Glu Ile Met Ala Ser Leu Phe Leu Ser Thr Asn Met
145                 150                 155                 160 
Gln Glu Arg Leu Arg Ser Lys Asp Arg Asp Leu Gly Ser Ser
                165                 170                 


<210> 23
<211> 351
<212> PRT
<213> Homo sapiens

<400> 23
Ala Arg Gly Cys His Ile Ala Gln Phe Lys Ser Leu Ser Pro Ala Glu
 1               5                  10                  15      
Leu Gln Ala Phe Lys Arg Ala Lys Asp Ala Leu Glu Glu Ser Leu Leu
            20                  25                  30          
Leu Lys Asp Cys Lys Cys Arg Ser Arg Leu Phe Pro Arg Thr Trp Asp
        35                  40                  45              
Leu Arg Gln Leu Gln Val Arg Glu Arg Pro Val Ala Leu Glu Ala Glu
    50                  55                  60                  
Leu Ala Leu Thr Leu Lys Val Leu Glu Ala Thr Ala Asp Thr Asp Pro
65                  70                  75                  80  
Ala Leu Gly Asp Val Leu Asp Ala Pro Leu Ala Thr Leu His His Ile
                85                  90                  95      
Leu Ser Gln Leu Arg Ala Cys Ile Gln Pro Gln Pro Thr Ala Gly Pro
            100                 105                 110         
Arg Thr Arg Gly Arg Leu His Arg Trp Leu His Arg Leu Gln Glu Ala
        115                 120                 125             
Pro Lys Lys Glu Ser Pro Gly Cys Leu Glu Ala Ser Val Thr Phe Asn
    130                 135                 140                 
Leu Phe Arg Leu Leu Ala Arg Asp Leu Asn Cys Val Ala Ser Gly Asp
145                 150                 155                 160 
Leu Cys Glu Gly Ser Gly Ser Gly Leu Gly Cys Asp Leu Pro Gln Asn
                165                 170                 175     
His Gly Leu Leu Ser Ala Asn Thr Leu Val Leu Leu His Gln Met Arg
            180                 185                 190         
Arg Ile Ser Pro Phe Leu Cys Ala Lys Asp Ala Arg Asp Phe Arg Phe
        195                 200                 205             
Pro Gln Glu Met Val Lys Gly Ser Gln Leu Gln Lys Ala His Val Met
    210                 215                 220                 
Ser Val Leu His Glu Met Leu Gln Gln Ile Phe Ser Leu Phe His Thr
225                 230                 235                 240 
Glu Arg Ser Ser Ala Ala Trp Asn Met Thr Leu Leu Asp Gln Leu His
                245                 250                 255     
Thr Gly Leu His Gln Gln Leu Gln His Leu Glu Thr Cys Leu Leu Gln
            260                 265                 270         
Val Val Gly Glu Gly Glu Ser Ala Gly Ala Ile Ser Ser Pro Ala Leu
        275                 280                 285             
Thr Leu Arg Arg Tyr Phe Gln Gly Ile Arg Val Tyr Leu Lys Glu Lys
    290                 295                 300                 
Lys Tyr Ser Asp Cys Ala Trp Glu Val Val Arg Met Glu Ile Met Ala
305                 310                 315                 320 
Ser Leu Phe Leu Ser Thr Asn Met Gln Glu Arg Leu Arg Ser Lys Asp
                325                 330                 335     
Arg Asp Leu Gly Ser Ser Ala Ala Ala His His His His His His
            340                 345                 350     

