                         SEQUENCE LISTING

<110>  University of Pittsburgh - Of the Commonwealth System of 
       Higher Education
       Gambotto , Andrea A
       Kim, Eun
       Erdos, Geza
       Falo, Louis D
 
<120>  ZIKA VIRUS VACCINES

<130>  8123-98249-03

<150>  62/402,557
<151>  2016-09-30

<150>  62/460,503
<151>  2017-02-17

<160>  13    

<170>  PatentIn version 3.5

<210>  1
<211>  4
<212>  PRT
<213>  Homo sapiens

<400>  1

Gln Val Gln Leu 
1               


<210>  2
<211>  21
<212>  PRT
<213>  Homo sapiens

<400>  2

Met Trp Trp Arg Leu Trp Trp Leu Leu Leu Leu Leu Leu Leu Leu Trp 
1               5                   10                  15      


Pro Met Val Trp Ala 
            20      


<210>  3
<211>  19
<212>  PRT
<213>  Mus musculus

<400>  3

Met Ala Val Leu Gly Leu Leu Phe Cys Leu Val Thr Phe Pro Ser Cys 
1               5                   10                  15      


Val Leu Ser 
            


<210>  4
<211>  19
<212>  PRT
<213>  Homo sapiens

<400>  4

Met Glu Phe Gly Leu Ser Trp Val Phe Leu Val Ala Leu Phe Arg Gly 
1               5                   10                  15      


Val Gln Cys 
            


<210>  5
<211>  22
<212>  PRT
<213>  Zika Virus

<400>  5

Arg Gly Ala Asp Thr Ser Val Gly Ile Val Gly Leu Leu Leu Thr Thr 
1               5                   10                  15      


Ala Met Ala Ala Glu Val 
            20          


<210>  6
<211>  405
<212>  PRT
<213>  Zika Virus

<400>  6

Ile Arg Cys Ile Gly Val Ser Asn Arg Asp Phe Val Glu Gly Met Ser 
1               5                   10                  15      


Gly Gly Thr Trp Val Asp Val Val Leu Glu His Gly Gly Cys Val Thr 
            20                  25                  30          


Val Met Ala Gln Asp Lys Pro Thr Val Asp Ile Glu Leu Val Thr Thr 
        35                  40                  45              


Thr Val Ser Asn Met Ala Glu Val Arg Ser Tyr Cys Tyr Glu Ala Ser 
    50                  55                  60                  


Ile Ser Asp Met Ala Ser Asp Ser Arg Cys Pro Thr Gln Gly Glu Ala 
65                  70                  75                  80  


Tyr Leu Asp Lys Gln Ser Asp Thr Gln Tyr Val Cys Lys Arg Thr Leu 
                85                  90                  95      


Val Asp Arg Gly Trp Gly Asn Gly Cys Gly Leu Phe Gly Lys Gly Ser 
            100                 105                 110         


Leu Val Thr Cys Ala Lys Phe Ala Cys Ser Lys Lys Met Thr Gly Lys 
        115                 120                 125             


Ser Ile Gln Pro Glu Asn Leu Glu Tyr Arg Ile Met Leu Ser Val His 
    130                 135                 140                 


Gly Ser Gln His Ser Gly Met Ile Val Asn Asp Thr Gly His Glu Thr 
145                 150                 155                 160 


Asp Glu Asn Arg Ala Lys Val Glu Ile Thr Pro Asn Ser Pro Arg Ala 
                165                 170                 175     


Glu Ala Thr Leu Gly Gly Phe Gly Ser Leu Gly Leu Asp Cys Glu Pro 
            180                 185                 190         


Arg Thr Gly Leu Asp Phe Ser Asp Leu Tyr Tyr Leu Thr Met Asn Asn 
        195                 200                 205             


Lys His Trp Leu Val His Lys Glu Trp Phe His Asp Ile Pro Leu Pro 
    210                 215                 220                 


Trp His Ala Gly Ala Asp Thr Gly Thr Pro His Trp Asn Asn Lys Glu 
225                 230                 235                 240 


Ala Leu Val Glu Phe Lys Asp Ala His Ala Lys Arg Gln Thr Val Val 
                245                 250                 255     


Val Leu Gly Ser Gln Glu Gly Ala Val His Thr Ala Leu Ala Gly Ala 
            260                 265                 270         


Leu Glu Ala Glu Met Asp Gly Ala Lys Gly Arg Leu Ser Ser Gly His 
        275                 280                 285             


Leu Lys Cys Arg Leu Lys Met Asp Lys Leu Arg Leu Lys Gly Val Ser 
    290                 295                 300                 


Tyr Ser Leu Cys Thr Ala Ala Phe Thr Phe Thr Lys Ile Pro Ala Glu 
305                 310                 315                 320 


Thr Leu His Gly Thr Val Thr Val Glu Val Gln Tyr Ala Gly Thr Asp 
                325                 330                 335     


Gly Pro Cys Lys Val Pro Ala Gln Met Ala Val Asp Met Gln Thr Leu 
            340                 345                 350         


Thr Pro Val Gly Arg Leu Ile Thr Ala Asn Pro Val Ile Thr Glu Ser 
        355                 360                 365             


Thr Glu Asn Ser Lys Met Met Leu Glu Leu Asp Pro Pro Phe Gly Asp 
    370                 375                 380                 


Ser Tyr Ile Val Ile Gly Val Gly Glu Lys Lys Ile Thr His His Trp 
385                 390                 395                 400 


His Arg Ser Gly Ser 
                405 


<210>  7
<211>  456
<212>  PRT
<213>  Zika Virus

<400>  7

Ile Arg Cys Ile Gly Val Ser Asn Arg Asp Phe Val Glu Gly Met Ser 
1               5                   10                  15      


Gly Gly Thr Trp Val Asp Val Val Leu Glu His Gly Gly Cys Val Thr 
            20                  25                  30          


Val Met Ala Gln Asp Lys Pro Thr Val Asp Ile Glu Leu Val Thr Thr 
        35                  40                  45              


Thr Val Ser Asn Met Ala Glu Val Arg Ser Tyr Cys Tyr Glu Ala Ser 
    50                  55                  60                  


Ile Ser Asp Met Ala Ser Asp Ser Arg Cys Pro Thr Gln Gly Glu Ala 
65                  70                  75                  80  


Tyr Leu Asp Lys Gln Ser Asp Thr Gln Tyr Val Cys Lys Arg Thr Leu 
                85                  90                  95      


Val Asp Arg Gly Trp Gly Asn Gly Cys Gly Leu Phe Gly Lys Gly Ser 
            100                 105                 110         


Leu Val Thr Cys Ala Lys Phe Ala Cys Ser Lys Lys Met Thr Gly Lys 
        115                 120                 125             


Ser Ile Gln Pro Glu Asn Leu Glu Tyr Arg Ile Met Leu Ser Val His 
    130                 135                 140                 


Gly Ser Gln His Ser Gly Met Ile Val Asn Asp Thr Gly His Glu Thr 
145                 150                 155                 160 


Asp Glu Asn Arg Ala Lys Val Glu Ile Thr Pro Asn Ser Pro Arg Ala 
                165                 170                 175     


Glu Ala Thr Leu Gly Gly Phe Gly Ser Leu Gly Leu Asp Cys Glu Pro 
            180                 185                 190         


Arg Thr Gly Leu Asp Phe Ser Asp Leu Tyr Tyr Leu Thr Met Asn Asn 
        195                 200                 205             


Lys His Trp Leu Val His Lys Glu Trp Phe His Asp Ile Pro Leu Pro 
    210                 215                 220                 


Trp His Ala Gly Ala Asp Thr Gly Thr Pro His Trp Asn Asn Lys Glu 
225                 230                 235                 240 


Ala Leu Val Glu Phe Lys Asp Ala His Ala Lys Arg Gln Thr Val Val 
                245                 250                 255     


Val Leu Gly Ser Gln Glu Gly Ala Val His Thr Ala Leu Ala Gly Ala 
            260                 265                 270         


Leu Glu Ala Glu Met Asp Gly Ala Lys Gly Arg Leu Ser Ser Gly His 
        275                 280                 285             


Leu Lys Cys Arg Leu Lys Met Asp Lys Leu Arg Leu Lys Gly Val Ser 
    290                 295                 300                 


Tyr Ser Leu Cys Thr Ala Ala Phe Thr Phe Thr Lys Ile Pro Ala Glu 
305                 310                 315                 320 


Thr Leu His Gly Thr Val Thr Val Glu Val Gln Tyr Ala Gly Thr Asp 
                325                 330                 335     


Gly Pro Cys Lys Val Pro Ala Gln Met Ala Val Asp Met Gln Thr Leu 
            340                 345                 350         


Thr Pro Val Gly Arg Leu Ile Thr Ala Asn Pro Val Ile Thr Glu Ser 
        355                 360                 365             


Thr Glu Asn Ser Lys Met Met Leu Glu Leu Asp Pro Pro Phe Gly Asp 
    370                 375                 380                 


Ser Tyr Ile Val Ile Gly Val Gly Glu Lys Lys Ile Thr His His Trp 
385                 390                 395                 400 


His Arg Ser Gly Ser Thr Ile Gly Lys Ala Phe Glu Ala Thr Val Arg 
                405                 410                 415     


Gly Ala Lys Arg Met Ala Val Leu Gly Asp Thr Ala Trp Asp Phe Gly 
            420                 425                 430         


Ser Val Gly Gly Ala Leu Asn Ser Leu Gly Lys Gly Ile His Gln Ile 
        435                 440                 445             


Phe Gly Ala Ala Phe Lys Ser Leu 
    450                 455     


<210>  8
<211>  165
<212>  PRT
<213>  Homo sapiens

<400>  8

Thr Arg Arg Gly Ser Ala Tyr Tyr Met Tyr Leu Asp Arg Asn Asp Ala 
1               5                   10                  15      


Gly Glu Ala Ile Ser Phe Pro Thr Thr Leu Gly Met Asn Lys Cys Tyr 
            20                  25                  30          


Ile Gln Ile Met Asp Leu Gly His Met Cys Asp Ala Thr Met Ser Tyr 
        35                  40                  45              


Glu Cys Pro Met Leu Asp Glu Gly Val Glu Pro Asp Asp Val Asp Cys 
    50                  55                  60                  


Trp Cys Asn Thr Thr Ser Thr Trp Val Val Tyr Gly Thr Cys His His 
65                  70                  75                  80  


Lys Lys Gly Glu Ala Arg Arg Ser Arg Arg Ala Val Thr Leu Pro Ser 
                85                  90                  95      


His Ser Thr Arg Lys Leu Gln Thr Arg Ser Gln Thr Trp Leu Glu Ser 
            100                 105                 110         


Arg Glu Tyr Thr Lys His Leu Ile Arg Val Glu Asn Trp Ile Phe Arg 
        115                 120                 125             


Asn Pro Gly Phe Ala Leu Ala Ala Ala Ala Ile Ala Trp Leu Leu Gly 
    130                 135                 140                 


Ser Ser Thr Ser Gln Lys Val Ile Tyr Leu Val Met Ile Leu Leu Ile 
145                 150                 155                 160 


Ala Pro Ala Tyr Ser 
                165 


<210>  9
<211>  229
<212>  PRT
<213>  Homo sapiens

<400>  9

Asp Lys Thr His Thr Cys Pro Ser Arg Pro Cys Pro Ala Pro Glu Leu 
1               5                   10                  15      


Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr 
            20                  25                  30          


Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val 
        35                  40                  45              


Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val 
    50                  55                  60                  


Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser 
65                  70                  75                  80  


Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu 
                85                  90                  95      


Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala 
            100                 105                 110         


Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro 
        115                 120                 125             


Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln 
    130                 135                 140                 


Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala 
145                 150                 155                 160 


Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr 
                165                 170                 175     


Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu 
            180                 185                 190         


Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser 
        195                 200                 205             


Val Leu His Glu Ala Leu His Ser His Tyr Thr Gln Lys Ser Leu Ser 
    210                 215                 220                 


Leu Ser Pro Gly Lys 
225                 


<210>  10
<211>  27
<212>  PRT
<213>  Bacteriophage T4

<400>  10

Gly Tyr Ile Pro Glu Ala Pro Arg Asp Gly Gln Ala Tyr Val Arg Lys 
1               5                   10                  15      


Asp Gly Glu Trp Val Leu Leu Ser Thr Phe Leu 
            20                  25          


<210>  11
<211>  63
<212>  PRT
<213>  Homo sapiens

<400>  11

Val Thr Ala Phe Ser Asn Met Asp Asp Met Leu Gln Lys Ala His Leu 
1               5                   10                  15      


Val Ile Glu Gly Thr Phe Ile Tyr Leu Arg Asp Ser Thr Glu Phe Phe 
            20                  25                  30          


Ile Arg Val Arg Asp Gly Trp Lys Lys Leu Gln Leu Gly Glu Leu Ile 
        35                  40                  45              


Pro Ile Pro Ala Asp Ser Pro Pro Pro Pro Ala Leu Ser Ser Asn 
    50                  55                  60              


<210>  12
<211>  822
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Immunogen

<400>  12

Met Ala Val Leu Gly Leu Leu Phe Cys Leu Val Thr Phe Pro Ser Cys 
1               5                   10                  15      


Val Leu Ser Gln Val Gln Leu Thr Arg Arg Gly Ser Ala Tyr Tyr Met 
            20                  25                  30          


Tyr Leu Asp Arg Asn Asp Ala Gly Glu Ala Ile Ser Phe Pro Thr Thr 
        35                  40                  45              


Leu Gly Met Asn Lys Cys Tyr Ile Gln Ile Met Asp Leu Gly His Met 
    50                  55                  60                  


Cys Asp Ala Thr Met Ser Tyr Glu Cys Pro Met Leu Asp Glu Gly Val 
65                  70                  75                  80  


Glu Pro Asp Asp Val Asp Cys Trp Cys Asn Thr Thr Ser Thr Trp Val 
                85                  90                  95      


Val Tyr Gly Thr Cys His His Lys Lys Gly Glu Ala Arg Arg Ser Arg 
            100                 105                 110         


Arg Ala Val Thr Leu Pro Ser His Ser Thr Arg Lys Leu Gln Thr Arg 
        115                 120                 125             


Ser Gln Thr Trp Leu Glu Ser Arg Glu Tyr Thr Lys His Leu Ile Arg 
    130                 135                 140                 


Val Glu Asn Trp Ile Phe Arg Asn Pro Gly Phe Ala Leu Ala Ala Ala 
145                 150                 155                 160 


Ala Ile Ala Trp Leu Leu Gly Ser Ser Thr Ser Gln Lys Val Ile Tyr 
                165                 170                 175     


Leu Val Met Ile Leu Leu Ile Ala Pro Ala Tyr Ser Ile Arg Cys Ile 
            180                 185                 190         


Gly Val Ser Asn Arg Asp Phe Val Glu Gly Met Ser Gly Gly Thr Trp 
        195                 200                 205             


Val Asp Val Val Leu Glu His Gly Gly Cys Val Thr Val Met Ala Gln 
    210                 215                 220                 


Asp Lys Pro Thr Val Asp Ile Glu Leu Val Thr Thr Thr Val Ser Asn 
225                 230                 235                 240 


Met Ala Glu Val Arg Ser Tyr Cys Tyr Glu Ala Ser Ile Ser Asp Met 
                245                 250                 255     


Ala Ser Asp Ser Arg Cys Pro Thr Gln Gly Glu Ala Tyr Leu Asp Lys 
            260                 265                 270         


Gln Ser Asp Thr Gln Tyr Val Cys Lys Arg Thr Leu Val Asp Arg Gly 
        275                 280                 285             


Trp Gly Asn Gly Cys Gly Leu Phe Gly Lys Gly Ser Leu Val Thr Cys 
    290                 295                 300                 


Ala Lys Phe Ala Cys Ser Lys Lys Met Thr Gly Lys Ser Ile Gln Pro 
305                 310                 315                 320 


Glu Asn Leu Glu Tyr Arg Ile Met Leu Ser Val His Gly Ser Gln His 
                325                 330                 335     


Ser Gly Met Ile Val Asn Asp Thr Gly His Glu Thr Asp Glu Asn Arg 
            340                 345                 350         


Ala Lys Val Glu Ile Thr Pro Asn Ser Pro Arg Ala Glu Ala Thr Leu 
        355                 360                 365             


Gly Gly Phe Gly Ser Leu Gly Leu Asp Cys Glu Pro Arg Thr Gly Leu 
    370                 375                 380                 


Asp Phe Ser Asp Leu Tyr Tyr Leu Thr Met Asn Asn Lys His Trp Leu 
385                 390                 395                 400 


Val His Lys Glu Trp Phe His Asp Ile Pro Leu Pro Trp His Ala Gly 
                405                 410                 415     


Ala Asp Thr Gly Thr Pro His Trp Asn Asn Lys Glu Ala Leu Val Glu 
            420                 425                 430         


Phe Lys Asp Ala His Ala Lys Arg Gln Thr Val Val Val Leu Gly Ser 
        435                 440                 445             


Gln Glu Gly Ala Val His Thr Ala Leu Ala Gly Ala Leu Glu Ala Glu 
    450                 455                 460                 


Met Asp Gly Ala Lys Gly Arg Leu Ser Ser Gly His Leu Lys Cys Arg 
465                 470                 475                 480 


Leu Lys Met Asp Lys Leu Arg Leu Lys Gly Val Ser Tyr Ser Leu Cys 
                485                 490                 495     


Thr Ala Ala Phe Thr Phe Thr Lys Ile Pro Ala Glu Thr Leu His Gly 
            500                 505                 510         


Thr Val Thr Val Glu Val Gln Tyr Ala Gly Thr Asp Gly Pro Cys Lys 
        515                 520                 525             


Val Pro Ala Gln Met Ala Val Asp Met Gln Thr Leu Thr Pro Val Gly 
    530                 535                 540                 


Arg Leu Ile Thr Ala Asn Pro Val Ile Thr Glu Ser Thr Glu Asn Ser 
545                 550                 555                 560 


Lys Met Met Leu Glu Leu Asp Pro Pro Phe Gly Asp Ser Tyr Ile Val 
                565                 570                 575     


Ile Gly Val Gly Glu Lys Lys Ile Thr His His Trp His Arg Ser Gly 
            580                 585                 590         


Ser Asp Lys Thr His Thr Cys Pro Ser Arg Pro Cys Pro Ala Pro Glu 
        595                 600                 605             


Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp 
    610                 615                 620                 


Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp 
625                 630                 635                 640 


Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly 
                645                 650                 655     


Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn 
            660                 665                 670         


Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp 
        675                 680                 685             


Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro 
    690                 695                 700                 


Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu 
705                 710                 715                 720 


Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn 
                725                 730                 735     


Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile 
            740                 745                 750         


Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr 
        755                 760                 765             


Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys 
    770                 775                 780                 


Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys 
785                 790                 795                 800 


Ser Val Leu His Glu Ala Leu His Ser His Tyr Thr Gln Lys Ser Leu 
                805                 810                 815     


Ser Leu Ser Pro Gly Lys 
            820         


<210>  13
<211>  4472
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nucleic Acid Encoding Immunogen

<400>  13
aagcttgcca ccatggccac ctcagcaagt tcccacttga acaaaggcat caagcaaatg       60

tacatgtccc tgccccaggg tgagaaagtc caagccatgt atatctgggt tgatggtacc      120

ggagaaggac tgcgctgcaa aacccgcacc ctggactgtg agcccaagtg tgtagaagag      180

ttacctgagt ggaattttga tggctctagt acctttcagt ctgagagctc caacagtgac      240

atgtatctca gccctgttgc catgtttcgg gaccccttcc gcaaagagcc caacaagctg      300

gtgttctgtg aagtcttcaa gtacaaccag aagcctgcag agaccaattt aagacacacg      360

tgtaaacgga taatggacat ggtgagcaac cagcacccct ggtttggaat ggaacaggag      420

tatactctct tgggaacaga tgggcaccct tttggttggc cttccgatgg cttccctggg      480

ccccaaggtc tgtattactg tggtgtgggc gcagacaaag cctatcgcag ggatatcatg      540

gaggctcact accgtgcctg cttgtatgct ggggtcaaga ttacaggaac atatgctgag      600

gtcaagcatg cccagtggga attccaaata ggaccctgtg aaggaatccg catgggagat      660

catctctggg tggcccgttt catcttgcat cgagtatgta aagactttgg agtaatagca      720

acctttgact ccaagcccat tcctgggaac tggaatggtg caggctgcca taccaacttt      780

agtaccaaga ccatgcggga ggagaatggt ctgaagcaca tcaaggaggc cattgagaaa      840

ctaagcaagc ggcaccggta ccatattcga gcctacgatc ccaagggggg gctggacaat      900

gcccgtcgtc tgactgggtt ccacaaaacg tccaacatca acgacttttc agctggcgtc      960

gccgatcgca gtgccagcat ccgcattccc cggactgtcg gccaggagaa gaaaggttac     1020

tttgaagccc gctgcccctc tgccaattgt gacccctttg cagtgacaga agccatcgtc     1080

cgcacatgcc ttctcaatga gactggcgac cagcccttcc aatacaaaaa cggcagcggc     1140

gcgaccaact ttagcctcct caagcaggcg ggggatgtgg aggagaaccc aggtcctatg     1200

gtgagcaagg gcgaggagct gttcaccggg gtggtgccca tcctggtcga gctggacggc     1260

gacgtaaacg gccacaagtt cagcgtgtcc ggcgagggcg agggcgatgc cacctacggc     1320

aagctgaccc tgaagttcat ctgcaccacc ggcaagctgc ccgtgccctg gcccaccctc     1380

gtgaccaccc tgacctacgg cgtgcagtgc ttcagccgct accccgacca catgaagcag     1440

cacgacttct tcaagtccgc catgcccgaa ggctacgtcc aggagcgcac catcttcttc     1500

aaggacgacg gcaactacaa gacccgcgcc gaggtgaagt tcgagggcga caccctggtg     1560

aaccgcatcg agctgaaggg catcgacttc aaggaggacg gcaacatcct ggggcacaag     1620

ctggagtaca actacaacag ccacaacgtc tatatcatgg ccgacaagca gaagaacggc     1680

atcaaggtga acttcaagat ccgccacaac atcgaggacg gcagcgtgca gctcgccgac     1740

cactaccagc agaacacccc catcggcgac ggccccgtgc tgctgcccga caaccactac     1800

ctgagcaccc agtccgccct gagcaaagac cccaacgaga agcgcgatca catggtcctg     1860

ctggagttcg tgaccgccgc cgggatcact ctcggcatgg acgagctgta caagggctcc     1920

ggccagtgta caaactacgc cctgcttaaa ttagccggcg acgtggagtc aaaccccggc     1980

cccgtcgaca tggccgttct gggtctcctg ttctgcctgg tcacattccc cagttgtgtg     2040

ctcagtcagg tgcagttgac taggcgggga agcgcctatt acatgtacct ggaccgaaac     2100

gatgccggcg aagccatctc cttccccacc acgctcggaa tgaacaaatg ctatatccag     2160

atcatggatc tagggcacat gtgcgacgcg accatgtcgt acgagtgtcc catgctggac     2220

gaaggcgttg agcctgacga cgtggactgc tggtgcaata ctactagcac ttgggtggtg     2280

tacgggacct gtcatcacaa gaagggcgag gcccggcgct cccgtcgcgc agtgaccctg     2340

ccctctcact caacccgcaa gctgcagact cggtcgcaga catggctgga gtcccgggag     2400

tacactaagc acctcattcg cgtggagaac tggatcttcc gcaaccccgg gtttgctctc     2460

gccgccgctg ccatcgcgtg gctgttagga agttccacgt cccagaaagt gatctacctg     2520

gttatgatcc tccttatcgc ccccgcctac tccatccgct gtattggggt gagtaaccgc     2580

gacttcgtgg aggggatgtc cggcggcacc tgggtggatg tggtgctgga gcacgggggc     2640

tgtgtgacgg tcatggcgca agacaagcct accgtggata tcgagctcgt gaccacaacc     2700

gtgtccaaca tggcagaggt ccggtcctat tgctatgaag ccagtatctc tgacatggcc     2760

agcgacagtc gctgcccgac gcagggggag gcctatctcg acaagcagtc ggatacccaa     2820

tacgtgtgta agcggactct cgtggaccga ggctggggca acggctgcgg cctgttcgga     2880

aagggcagcc tcgtaacttg cgccaagttc gcgtgctcta agaagatgac cggtaagagt     2940

atccagccgg agaacctgga atacaggatc atgctctcgg tgcacggctc ccagcactcc     3000

ggcatgatcg ttaacgacac cggccacgaa accgatgaga accgcgctaa ggtggagatc     3060

accccaaact ccccccgggc ggaggctacc ctgggcgggt tcgggtcgct cgggctcgac     3120

tgtgagccca ggaccggcct ggatttctcg gatctgtact acctgaccat gaataataag     3180

cactggctgg tgcacaagga gtggttccac gacatcccgt taccctggca cgcaggcgcc     3240

gacaccggga cacctcactg gaacaacaag gaggccttag tcgagttcaa ggatgcccac     3300

gccaaacggc agaccgtggt ggtgttaggc tcccaggaag gggccgtgca caccgccctg     3360

gccggtgccc tggaggccga gatggatggc gccaaaggcc gcctgtcatc cggacacctg     3420

aagtgccgcc tcaagatgga caagttgagg ctgaaggggg tgtcttattc gctgtgtacc     3480

gcagccttca cgttcacaaa gatcccagcc gagacactgc acgggaccgt caccgtggag     3540

gttcagtacg ccgggaccga cgggccgtgc aaggttcccg cccagatggc agtggacatg     3600

cagaccctga caccagtcgg ccgactcatt acggccaacc cagtcatcac cgagtccacg     3660

gagaactcca agatgatgct cgaactggac ccccctttcg gtgacagtta catcgtgatc     3720

ggcgtgggcg aaaagaagat cactcaccac tggcatcggt caggatccga caagactcat     3780

acctgtccat cgcgcccttg ccccgccccc gagctccttg gcggtccatc cgtgttcctg     3840

tttccaccaa agccgaaaga taccctgatg atctcccgga cccccgaggt gacctgcgtg     3900

gtggtggacg tgagtcacga ggaccccgag gtgaagttca actggtacgt cgatggggtc     3960

gaggtgcaca acgcgaagac gaagccaagg gaggagcagt acaactccac ctacagggtg     4020

gtctcggttc tcaccgtcct gcaccaggac tggctgaatg gcaaggagta caagtgcaag     4080

gtgtcgaaca aggcactgcc cgcaccaatc gaaaagacaa tatccaaggc aaaaggacag     4140

ccgagagagc cccaggtgta taccctgccc ccgtcgcgag acgagctgac caagaatcag     4200

gtgagtctga cgtgcctggt gaagggcttt tatcccagcg acatcgctgt ggaatgggag     4260

agtaatggcc agcccgagaa caactataag accacccctc ccgtcctgga ttcggatggg     4320

agtttcttcc tgtactcgaa gctcactgtc gataagtccc ggtggcagca ggggaacgtg     4380

ttttcctgct ccgttctgca cgaagcgctg cattcgcact acacccagaa atcgcttagt     4440

ctctcccccg gcaagtaagc ggccgcctcg ag                                   4472


