                               SEQUENCE LISTING

<110> THE BRIGHAM AND WOMEN'S HOSPITAL, INC.
 
<120> NATURAL KILLER CELL-EVASIVE ONCOLYTIC VIRUSES

<130> 043214-088061-PCT

<140> PCT/US2017/054371
<141> 2017-09-29

<150> 62/402,473
<151> 2016-09-30

<160> 26    

<170> PatentIn version 3.5

<210> 1
<211> 400
<212> PRT
<213> Pseudorabies virus

<400> 1
Met Leu Leu Ala Ala Leu Leu Ala Ala Leu Val Ala Arg Thr Thr Leu 
1               5                   10                  15      


Gly Ala Asp Val Asp Ala Val Pro Ala Pro Thr Phe Pro Pro Pro Ala 
            20                  25                  30          


Tyr Pro Tyr Thr Glu Ser Trp Gln Leu Thr Leu Thr Thr Val Pro Ser 
        35                  40                  45              


Pro Phe Val Gly Pro Ala Asp Val Tyr His Thr Arg Pro Leu Glu Asp 
    50                  55                  60                  


Pro Cys Gly Val Val Ala Leu Ile Ser Asp Pro Gln Val Asp Arg Leu 
65                  70                  75                  80  


Leu Asn Glu Ala Val Ala His Arg Arg Pro Thr Tyr Arg Ala His Val 
                85                  90                  95      


Ala Trp Tyr Arg Ile Ala Asp Gly Cys Ala His Leu Leu Tyr Phe Ile 
            100                 105                 110         


Glu Tyr Ala Asp Cys Asp Pro Arg Gln Ile Phe Gly Arg Cys Arg Arg 
        115                 120                 125             


Arg Thr Thr Pro Met Trp Trp Thr Pro Ser Ala Asp Tyr Met Phe Pro 
    130                 135                 140                 


Thr Glu Asp Glu Leu Gly Leu Leu Met Val Ala Pro Gly Arg Phe Asn 
145                 150                 155                 160 


Glu Gly Gln Tyr Arg Arg Leu Val Ser Val Asp Gly Val Asn Ile Leu 
                165                 170                 175     


Thr Asp Phe Met Val Ala Leu Pro Glu Gly Gln Glu Cys Pro Phe Ala 
            180                 185                 190         


Arg Val Asp Gln His Arg Thr Tyr Lys Phe Gly Ala Cys Trp Asn Asp 
        195                 200                 205             


Glu Ser Phe Arg Arg Gly Val Asp Val Met Arg Phe Leu Thr Pro Phe 
    210                 215                 220                 


Tyr Gln Gln Pro Pro His Arg Glu Val Val Asn Tyr Trp Tyr Arg Lys 
225                 230                 235                 240 


Asn Gly Arg Thr Leu Pro Arg Ala Tyr Ala Ala Ala Thr Pro Tyr Ala 
                245                 250                 255     


Ile Asp Pro Ala Arg Pro Ser Ala Gly Ser Pro Arg Pro Arg Pro Arg 
            260                 265                 270         


Pro Arg Pro Arg Pro Lys Pro Glu Pro Ala Pro Val Thr Pro Ala Pro 
        275                 280                 285             


Pro Gly Arg Leu Pro Glu Pro Ala Thr Arg Asp His Ala Ala Gly Gly 
    290                 295                 300                 


His Pro Thr Pro Arg Pro Pro Arg Pro Glu Thr Pro His Arg Pro Phe 
305                 310                 315                 320 


Ala Pro Pro Ala Val Val Pro Ser Gly Trp Pro Gln Pro Ala Glu Pro 
                325                 330                 335     


Phe Gln Pro Arg Thr Pro Ala Ala Pro Gly Val Ser Arg His Arg Ser 
            340                 345                 350         


Val Ile Val Gly Thr Gly Thr Ala Met Gly Ala Leu Leu Val Gly Val 
        355                 360                 365             


Cys Val Tyr Ile Phe Phe Arg Leu Arg Gly Ala Lys Gly Tyr Arg Leu 
    370                 375                 380                 


Leu Gly Gly Pro Ala Asp Thr Asp Glu Leu Lys Ala Gln Pro Gly Pro 
385                 390                 395                 400 


<210> 2
<211> 351
<212> PRT
<213> Pseudorabies virus

<400> 2
Met Leu Leu Ala Ala Leu Leu Ala Ala Leu Val Ala Arg Thr Thr Leu 
1               5                   10                  15      


Gly Ala Asp Val Asp Ala Val Pro Ala Pro Thr Phe Pro Pro Pro Ala 
            20                  25                  30          


Tyr Pro Tyr Thr Glu Ser Trp Gln Leu Thr Leu Thr Thr Val Pro Ser 
        35                  40                  45              


Pro Phe Val Gly Pro Ala Asp Val Tyr His Thr Arg Pro Leu Glu Asp 
    50                  55                  60                  


Pro Cys Gly Val Val Ala Leu Ile Ser Asp Pro Gln Val Asp Arg Leu 
65                  70                  75                  80  


Leu Asn Glu Ala Val Ala His Arg Arg Pro Thr Tyr Arg Ala His Val 
                85                  90                  95      


Ala Trp Tyr Arg Ile Ala Asp Gly Cys Ala His Leu Leu Tyr Phe Ile 
            100                 105                 110         


Glu Tyr Ala Asp Cys Asp Pro Arg Gln Ile Phe Gly Arg Cys Arg Arg 
        115                 120                 125             


Arg Thr Thr Pro Met Trp Trp Thr Pro Ser Ala Asp Tyr Met Phe Pro 
    130                 135                 140                 


Thr Glu Asp Glu Leu Gly Leu Leu Met Val Ala Pro Gly Arg Phe Asn 
145                 150                 155                 160 


Glu Gly Gln Tyr Arg Arg Leu Val Ser Val Asp Gly Val Asn Ile Leu 
                165                 170                 175     


Thr Asp Phe Met Val Ala Leu Pro Glu Gly Gln Glu Cys Pro Phe Ala 
            180                 185                 190         


Arg Val Asp Gln His Arg Thr Tyr Lys Phe Gly Ala Cys Trp Asn Asp 
        195                 200                 205             


Glu Ser Phe Arg Arg Gly Val Asp Val Met Arg Phe Leu Thr Pro Phe 
    210                 215                 220                 


Tyr Gln Gln Pro Pro His Arg Glu Val Val Asn Tyr Trp Tyr Arg Lys 
225                 230                 235                 240 


Asn Gly Arg Thr Leu Pro Arg Ala Tyr Ala Ala Ala Thr Pro Tyr Ala 
                245                 250                 255     


Ile Asp Pro Ala Arg Pro Ser Ala Gly Ser Pro Arg Pro Arg Pro Arg 
            260                 265                 270         


Pro Arg Pro Arg Pro Lys Pro Glu Pro Ala Pro Val Thr Pro Ala Pro 
        275                 280                 285             


Pro Gly Arg Leu Pro Glu Pro Ala Thr Arg Asp His Ala Ala Gly Gly 
    290                 295                 300                 


His Pro Thr Pro Arg Pro Pro Arg Pro Glu Thr Pro His Arg Pro Phe 
305                 310                 315                 320 


Ala Pro Pro Ala Val Val Pro Ser Gly Trp Pro Gln Pro Ala Glu Pro 
                325                 330                 335     


Phe Gln Pro Arg Thr Pro Ala Ala Pro Gly Val Ser Arg His Arg 
            340                 345                 350     


<210> 3
<211> 5
<212> PRT
<213> Pseudorabies virus

<400> 3
Thr Pro Ser Ala Asp 
1               5   


<210> 4
<211> 6
<212> PRT
<213> Pseudorabies virus

<400> 4
Asp Gln His Arg Thr Tyr 
1               5       


<210> 5
<211> 4
<212> PRT
<213> Pseudorabies virus

<400> 5
Val Met Arg Phe 
1               


<210> 6
<211> 14
<212> PRT
<213> Pseudorabies virus

<400> 6
Gln Pro Pro His Arg Glu Val Val Asn Tyr Trp Tyr Arg Lys 
1               5                   10                  


<210> 7
<211> 248
<212> PRT
<213> Pseudorabies virus

<400> 7
Val Ala Arg Thr Thr Leu Gly Ala Asp Val Asp Ala Val Pro Ala Pro 
1               5                   10                  15      


Thr Phe Pro Pro Pro Ala Tyr Pro Tyr Thr Glu Ser Trp Gln Leu Thr 
            20                  25                  30          


Leu Thr Thr Val Pro Ser Pro Phe Val Gly Pro Ala Asp Val Tyr His 
        35                  40                  45              


Thr Arg Pro Leu Glu Asp Pro Cys Gly Val Val Ala Leu Ile Ser Asp 
    50                  55                  60                  


Pro Gln Val Asp Arg Leu Leu Asn Glu Ala Val Ala His Arg Arg Pro 
65                  70                  75                  80  


Thr Tyr Arg Ala His Val Ala Trp Tyr Arg Ile Ala Asp Gly Cys Ala 
                85                  90                  95      


His Leu Leu Tyr Phe Ile Glu Tyr Ala Asp Cys Asp Pro Arg Gln Ile 
            100                 105                 110         


Phe Gly Arg Cys Arg Arg Arg Thr Thr Pro Met Trp Trp Thr Pro Ser 
        115                 120                 125             


Ala Asp Tyr Met Phe Pro Thr Glu Asp Glu Leu Gly Leu Leu Met Val 
    130                 135                 140                 


Ala Pro Gly Arg Phe Asn Glu Gly Gln Tyr Arg Arg Leu Val Ser Val 
145                 150                 155                 160 


Asp Gly Val Asn Ile Leu Thr Asp Phe Met Val Ala Leu Pro Glu Gly 
                165                 170                 175     


Gln Glu Cys Pro Phe Ala Arg Val Asp Gln His Arg Thr Tyr Lys Phe 
            180                 185                 190         


Gly Ala Cys Trp Asn Asp Glu Ser Phe Arg Arg Gly Val Asp Val Met 
        195                 200                 205             


Arg Phe Leu Thr Pro Phe Tyr Gln Gln Pro Pro His Arg Glu Val Val 
    210                 215                 220                 


Asn Tyr Trp Tyr Arg Lys Asn Gly Arg Thr Leu Pro Arg Ala Tyr Ala 
225                 230                 235                 240 


Ala Ala Thr Pro Tyr Ala Ile Asp 
                245             


<210> 8
<211> 17
<212> PRT
<213> Pseudorabies virus

<400> 8
Met Leu Leu Ala Ala Leu Leu Ala Ala Leu Val Ala Arg Thr Thr Leu 
1               5                   10                  15      


Gly 
    


<210> 9
<211> 338
<212> PRT
<213> Human cytomegalovirus

<400> 9
Met Cys Arg Arg Glu Ser Leu Arg Thr Leu Pro Trp Leu Phe Trp Val 
1               5                   10                  15      


Leu Leu Ser Cys Pro Arg Leu Leu Glu Tyr Ser Ser Ser Ser Phe Pro 
            20                  25                  30          


Phe Ala Thr Ala Asp Ile Ala Glu Lys Met Trp Ala Glu Asn Tyr Glu 
        35                  40                  45              


Thr Thr Ser Pro Ala Pro Val Leu Val Ala Glu Gly Glu Gln Val Thr 
    50                  55                  60                  


Ile Pro Cys Thr Val Met Thr His Ser Trp Pro Met Val Ser Ile Arg 
65                  70                  75                  80  


Ala Arg Phe Cys Arg Ser His Asp Gly Ser Asp Glu Leu Ile Leu Asp 
                85                  90                  95      


Ala Val Lys Gly His Arg Leu Met Asn Gly Leu Gln Tyr Arg Leu Pro 
            100                 105                 110         


Tyr Ala Thr Trp Asn Phe Ser Gln Leu His Leu Gly Gln Ile Phe Ser 
        115                 120                 125             


Leu Thr Phe Asn Val Ser Thr Asp Thr Ala Gly Met Tyr Glu Cys Val 
    130                 135                 140                 


Leu Arg Asn Tyr Ser His Gly Leu Ile Met Gln Arg Phe Val Ile Leu 
145                 150                 155                 160 


Thr Gln Leu Glu Thr Leu Ser Arg Pro Asp Glu Pro Cys Cys Thr Pro 
                165                 170                 175     


Ala Leu Gly Arg Tyr Ser Leu Gly Asp Gln Ile Trp Ser Pro Thr Pro 
            180                 185                 190         


Trp Arg Leu Arg Asn His Asp Cys Gly Met Tyr Arg Gly Phe Gln Arg 
        195                 200                 205             


Asn Tyr Phe Tyr Ile Gly Arg Ala Asp Ala Glu Asp Cys Trp Lys Pro 
    210                 215                 220                 


Ala Cys Pro Asp Glu Glu Pro Asp Arg Cys Trp Thr Val Ile Gln Arg 
225                 230                 235                 240 


Tyr Arg Leu Pro Gly Asp Cys Tyr Arg Ser Gln Pro His Pro Pro Lys 
                245                 250                 255     


Phe Leu Pro Val Thr Pro Ala Pro Pro Ala Asp Ile Asp Thr Gly Met 
            260                 265                 270         


Ser Pro Trp Ala Thr Arg Gly Ile Ala Ala Phe Leu Gly Phe Trp Ser 
        275                 280                 285             


Ile Phe Thr Val Cys Phe Leu Cys Tyr Leu Cys Tyr Leu Gln Cys Cys 
    290                 295                 300                 


Gly Arg Trp Cys Pro Thr Pro Gly Arg Gly Arg Arg Gly Gly Glu Gly 
305                 310                 315                 320 


Tyr Arg Arg Leu Pro Thr Tyr Asp Ser Tyr Pro Gly Val Lys Lys Met 
                325                 330                 335     


Lys Arg 
        


<210> 10
<211> 279
<212> PRT
<213> Human cytomegalovirus

<400> 10
Met Cys Arg Arg Glu Ser Leu Arg Thr Leu Pro Trp Leu Phe Trp Val 
1               5                   10                  15      


Leu Leu Ser Cys Pro Arg Leu Leu Glu Tyr Ser Ser Ser Ser Phe Pro 
            20                  25                  30          


Phe Ala Thr Ala Asp Ile Ala Glu Lys Met Trp Ala Glu Asn Tyr Glu 
        35                  40                  45              


Thr Thr Ser Pro Ala Pro Val Leu Val Ala Glu Gly Glu Gln Val Thr 
    50                  55                  60                  


Ile Pro Cys Thr Val Met Thr His Ser Trp Pro Met Val Ser Ile Arg 
65                  70                  75                  80  


Ala Arg Phe Cys Arg Ser His Asp Gly Ser Asp Glu Leu Ile Leu Asp 
                85                  90                  95      


Ala Val Lys Gly His Arg Leu Met Asn Gly Leu Gln Tyr Arg Leu Pro 
            100                 105                 110         


Tyr Ala Thr Trp Asn Phe Ser Gln Leu His Leu Gly Gln Ile Phe Ser 
        115                 120                 125             


Leu Thr Phe Asn Val Ser Thr Asp Thr Ala Gly Met Tyr Glu Cys Val 
    130                 135                 140                 


Leu Arg Asn Tyr Ser His Gly Leu Ile Met Gln Arg Phe Val Ile Leu 
145                 150                 155                 160 


Thr Gln Leu Glu Thr Leu Ser Arg Pro Asp Glu Pro Cys Cys Thr Pro 
                165                 170                 175     


Ala Leu Gly Arg Tyr Ser Leu Gly Asp Gln Ile Trp Ser Pro Thr Pro 
            180                 185                 190         


Trp Arg Leu Arg Asn His Asp Cys Gly Met Tyr Arg Gly Phe Gln Arg 
        195                 200                 205             


Asn Tyr Phe Tyr Ile Gly Arg Ala Asp Ala Glu Asp Cys Trp Lys Pro 
    210                 215                 220                 


Ala Cys Pro Asp Glu Glu Pro Asp Arg Cys Trp Thr Val Ile Gln Arg 
225                 230                 235                 240 


Tyr Arg Leu Pro Gly Asp Cys Tyr Arg Ser Gln Pro His Pro Pro Lys 
                245                 250                 255     


Phe Leu Pro Val Thr Pro Ala Pro Pro Ala Asp Ile Asp Thr Gly Met 
            260                 265                 270         


Ser Pro Trp Ala Thr Arg Gly 
        275                 


<210> 11
<211> 25
<212> PRT
<213> Human cytomegalovirus

<400> 11
Met Cys Arg Arg Glu Ser Leu Arg Thr Leu Pro Trp Leu Phe Trp Val 
1               5                   10                  15      


Leu Leu Ser Cys Pro Arg Leu Leu Glu 
            20                  25  


<210> 12
<211> 274
<212> PRT
<213> Human cytomegalovirus

<400> 12
Met Cys Arg Arg Glu Ser Leu Arg Thr Leu Pro Trp Leu Phe Trp Val 
1               5                   10                  15      


Leu Leu Ser Cys Pro Arg Leu Leu Glu Tyr Ser Ser Ser Ser Phe Pro 
            20                  25                  30          


Phe Ala Thr Ala Asp Ile Ala Glu Lys Met Trp Ala Glu Asn Tyr Glu 
        35                  40                  45              


Thr Thr Ser Pro Ala Pro Val Leu Val Ala Glu Gly Glu Gln Val Thr 
    50                  55                  60                  


Ile Pro Cys Thr Val Met Thr His Ser Trp Pro Met Val Ser Ile Arg 
65                  70                  75                  80  


Ala Arg Phe Cys Arg Ser His Asp Gly Ser Asp Glu Leu Ile Leu Asp 
                85                  90                  95      


Ala Val Lys Gly His Arg Leu Met Asn Gly Leu Gln Tyr Arg Leu Pro 
            100                 105                 110         


Tyr Ala Thr Trp Asn Phe Ser Gln Leu His Leu Gly Gln Ile Phe Ser 
        115                 120                 125             


Leu Thr Phe Asn Val Ser Thr Asp Thr Ala Gly Met Tyr Glu Cys Val 
    130                 135                 140                 


Leu Arg Asn Tyr Ser His Gly Leu Ile Met Gln Arg Phe Val Ile Leu 
145                 150                 155                 160 


Thr Gln Leu Glu Thr Leu Ser Arg Pro Asp Glu Pro Cys Cys Thr Pro 
                165                 170                 175     


Ala Leu Gly Arg Tyr Ser Leu Gly Asp Gln Ile Trp Ser Pro Thr Pro 
            180                 185                 190         


Trp Arg Leu Arg Asn His Asp Cys Gly Met Tyr Arg Gly Phe Gln Arg 
        195                 200                 205             


Asn Tyr Phe Tyr Ile Gly Arg Ala Asp Ala Glu Asp Cys Trp Lys Pro 
    210                 215                 220                 


Ala Cys Pro Asp Glu Glu Pro Asp Arg Cys Trp Thr Val Ile Gln Arg 
225                 230                 235                 240 


Tyr Arg Leu Pro Gly Asp Cys Tyr Arg Ser Gln Pro His Pro Pro Lys 
                245                 250                 255     


Phe Leu Pro Val Thr Pro Ala Pro Pro Ala Asp Ile Asp Thr Gly Met 
            260                 265                 270         


Ser Pro 
        


<210> 13
<211> 222
<212> PRT
<213> Human cytomegalovirus

<400> 13
Pro Arg Leu Leu Glu Tyr Ser Ser Ser Ser Phe Pro Phe Ala Thr Ala 
1               5                   10                  15      


Asp Ile Ala Glu Lys Met Trp Ala Glu Asn Tyr Glu Thr Thr Ser Pro 
            20                  25                  30          


Ala Pro Val Leu Val Ala Glu Gly Glu Gln Val Thr Ile Pro Cys Thr 
        35                  40                  45              


Val Met Thr His Ser Trp Pro Met Val Ser Ile Arg Ala Arg Phe Cys 
    50                  55                  60                  


Arg Ser His Asp Gly Ser Asp Glu Leu Ile Leu Asp Ala Val Lys Gly 
65                  70                  75                  80  


His Arg Leu Met Asn Gly Leu Gln Tyr Arg Leu Pro Tyr Ala Thr Trp 
                85                  90                  95      


Asn Phe Ser Gln Leu His Leu Gly Gln Ile Phe Ser Leu Thr Phe Asn 
            100                 105                 110         


Val Ser Thr Asp Thr Ala Gly Met Tyr Glu Cys Val Leu Arg Asn Tyr 
        115                 120                 125             


Ser His Gly Leu Ile Met Gln Arg Phe Val Ile Leu Thr Gln Leu Glu 
    130                 135                 140                 


Thr Leu Ser Arg Pro Asp Glu Pro Cys Cys Thr Pro Ala Leu Gly Arg 
145                 150                 155                 160 


Tyr Ser Leu Gly Asp Gln Ile Trp Ser Pro Thr Pro Trp Arg Leu Arg 
                165                 170                 175     


Asn His Asp Cys Gly Met Tyr Arg Gly Phe Gln Arg Asn Tyr Phe Tyr 
            180                 185                 190         


Ile Gly Arg Ala Asp Ala Glu Asp Cys Trp Lys Pro Ala Cys Pro Asp 
        195                 200                 205             


Glu Glu Pro Asp Arg Cys Trp Thr Val Ile Gln Arg Tyr Arg 
    210                 215                 220         


<210> 14
<211> 7
<212> PRT
<213> Human cytomegalovirus

<400> 14
Asp Glu Leu Ile Leu Asp Ala 
1               5           


<210> 15
<211> 6
<212> PRT
<213> Human cytomegalovirus

<400> 15
His Arg Leu Met Asn Gly 
1               5       


<210> 16
<211> 10
<212> PRT
<213> Human cytomegalovirus

<400> 16
Ala Gly Met Tyr Glu Cys Val Leu Arg Asn 
1               5                   10  


<210> 17
<211> 13
<212> PRT
<213> Human cytomegalovirus

<400> 17
Ser His Gly Leu Ile Met Gln Arg Phe Val Ile Leu Thr 
1               5                   10              


<210> 18
<211> 241
<212> PRT
<213> Pseudorabies virus

<400> 18
Ala Asp Val Asp Ala Val Pro Ala Pro Thr Phe Pro Pro Pro Ala Tyr 
1               5                   10                  15      


Pro Tyr Thr Glu Ser Trp Gln Leu Thr Leu Thr Thr Val Pro Ser Pro 
            20                  25                  30          


Phe Val Gly Pro Ala Asp Val Tyr His Thr Arg Pro Leu Glu Asp Pro 
        35                  40                  45              


Cys Gly Val Val Ala Leu Ile Ser Asp Pro Gln Val Asp Arg Leu Leu 
    50                  55                  60                  


Asn Glu Ala Val Ala His Arg Arg Pro Thr Tyr Arg Ala His Val Ala 
65                  70                  75                  80  


Trp Tyr Arg Ile Ala Asp Gly Cys Ala His Leu Leu Tyr Phe Ile Glu 
                85                  90                  95      


Tyr Ala Asp Cys Asp Pro Arg Gln Ile Phe Gly Arg Cys Arg Arg Arg 
            100                 105                 110         


Thr Thr Pro Met Trp Trp Thr Pro Ser Ala Asp Tyr Met Phe Pro Thr 
        115                 120                 125             


Glu Asp Glu Leu Gly Leu Leu Met Val Ala Pro Gly Arg Phe Asn Glu 
    130                 135                 140                 


Gly Gln Tyr Arg Arg Leu Val Ser Val Asp Gly Val Asn Ile Leu Thr 
145                 150                 155                 160 


Asp Phe Met Val Ala Leu Pro Glu Gly Gln Glu Cys Pro Phe Ala Arg 
                165                 170                 175     


Val Asp Gln His Arg Thr Tyr Lys Phe Gly Ala Cys Trp Asn Asp Glu 
            180                 185                 190         


Ser Phe Arg Arg Gly Val Asp Val Met Arg Phe Leu Thr Pro Phe Tyr 
        195                 200                 205             


Gln Gln Pro Pro His Arg Glu Val Val Asn Tyr Trp Tyr Arg Lys Asn 
    210                 215                 220                 


Gly Arg Thr Leu Pro Arg Ala Tyr Ala Ala Ala Thr Pro Tyr Ala Ile 
225                 230                 235                 240 


Asp 
    


<210> 19
<211> 105
<212> PRT
<213> Pseudorabies virus

<400> 19
Thr Pro Ser Ala Asp Tyr Met Phe Pro Thr Glu Asp Glu Leu Gly Leu 
1               5                   10                  15      


Leu Met Val Ala Pro Gly Arg Phe Asn Glu Gly Gln Tyr Arg Arg Leu 
            20                  25                  30          


Val Ser Val Asp Gly Val Asn Ile Leu Thr Asp Phe Met Val Ala Leu 
        35                  40                  45              


Pro Glu Gly Gln Glu Cys Pro Phe Ala Arg Val Asp Gln His Arg Thr 
    50                  55                  60                  


Tyr Lys Phe Gly Ala Cys Trp Asn Asp Glu Ser Phe Arg Arg Gly Val 
65                  70                  75                  80  


Asp Val Met Arg Phe Leu Thr Pro Phe Tyr Gln Gln Pro Pro His Arg 
                85                  90                  95      


Glu Val Val Asn Tyr Trp Tyr Arg Lys 
            100                 105 


<210> 20
<211> 161
<212> PRT
<213> Human cytomegalovirus

<400> 20
Arg Ala Arg Phe Cys Arg Ser His Asp Gly Ser Asp Glu Leu Ile Leu 
1               5                   10                  15      


Asp Ala Val Lys Gly His Arg Leu Met Asn Gly Leu Gln Tyr Arg Leu 
            20                  25                  30          


Pro Tyr Ala Thr Trp Asn Phe Ser Gln Leu His Leu Gly Gln Ile Phe 
        35                  40                  45              


Ser Leu Thr Phe Asn Val Ser Thr Asp Thr Ala Gly Met Tyr Glu Cys 
    50                  55                  60                  


Val Leu Arg Asn Tyr Ser His Gly Leu Ile Met Gln Arg Phe Val Ile 
65                  70                  75                  80  


Leu Thr Gln Leu Glu Thr Leu Ser Arg Pro Asp Glu Pro Cys Cys Thr 
                85                  90                  95      


Pro Ala Leu Gly Arg Tyr Ser Leu Gly Asp Gln Ile Trp Ser Pro Thr 
            100                 105                 110         


Pro Trp Arg Leu Arg Asn His Asp Cys Gly Met Tyr Arg Gly Phe Gln 
        115                 120                 125             


Arg Asn Tyr Phe Tyr Ile Gly Arg Ala Asp Ala Glu Asp Cys Trp Lys 
    130                 135                 140                 


Pro Ala Cys Pro Asp Glu Glu Pro Asp Arg Cys Trp Thr Val Ile Gln 
145                 150                 155                 160 


Arg 
    


<210> 21
<211> 71
<212> PRT
<213> Human cytomegalovirus

<400> 21
Asp Glu Leu Ile Leu Asp Ala Val Lys Gly His Arg Leu Met Asn Gly 
1               5                   10                  15      


Leu Gln Tyr Arg Leu Pro Tyr Ala Thr Trp Asn Phe Ser Gln Leu His 
            20                  25                  30          


Leu Gly Gln Ile Phe Ser Leu Thr Phe Asn Val Ser Thr Asp Thr Ala 
        35                  40                  45              


Gly Met Tyr Glu Cys Val Leu Arg Asn Tyr Ser His Gly Leu Ile Met 
    50                  55                  60                  


Gln Arg Phe Val Ile Leu Thr 
65                  70      


<210> 22
<211> 10
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown: 
      Kozak sequence

<400> 22
Gly Cys Cys Arg Cys Cys Ala Thr Gly Gly 
1               5                   10  


<210> 23
<211> 1369
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide


<220>
<221> CDS
<222> (25)..(1224)

<400> 23
accggtctcg aggctagcgc cacc atg ctg ctc gct gct ctg ctg gct gca          51
                           Met Leu Leu Ala Ala Leu Leu Ala Ala            
                           1               5                              

ctg gtg gcc aga aca aca ctg ggc gcc gat gtg gat gcc gtg cct gcc         99
Leu Val Ala Arg Thr Thr Leu Gly Ala Asp Val Asp Ala Val Pro Ala           
10                  15                  20                  25            

cct aca ttc cct cca ccc gcc tac cct tac acc gag agc tgg cag ctg        147
Pro Thr Phe Pro Pro Pro Ala Tyr Pro Tyr Thr Glu Ser Trp Gln Leu           
                30                  35                  40                

acc ctg acc acc gtg cct agc cct ttt gtg ggc cct gcc gac gtg tac        195
Thr Leu Thr Thr Val Pro Ser Pro Phe Val Gly Pro Ala Asp Val Tyr           
            45                  50                  55                    

cac aca aga ccc ctg gaa gat ccc tgc ggc gtg gtg gcc ctg atc agc        243
His Thr Arg Pro Leu Glu Asp Pro Cys Gly Val Val Ala Leu Ile Ser           
        60                  65                  70                        

gat cct cag gtg gac aga ctg ctg aac gag gcc gtg gcc cac aga agg        291
Asp Pro Gln Val Asp Arg Leu Leu Asn Glu Ala Val Ala His Arg Arg           
    75                  80                  85                            

cct acc tac aga gcc cac gtg gcc tgg tac aga atc gcc gac ggc tgt        339
Pro Thr Tyr Arg Ala His Val Ala Trp Tyr Arg Ile Ala Asp Gly Cys           
90                  95                  100                 105           

gcc cat ctg ctg tac ttc atc gag tac gcc gac tgc gac ccc aga cag        387
Ala His Leu Leu Tyr Phe Ile Glu Tyr Ala Asp Cys Asp Pro Arg Gln           
                110                 115                 120               

atc ttc ggc aga tgc agg cgg aga acc acc ccc atg tgg tgg aca cct        435
Ile Phe Gly Arg Cys Arg Arg Arg Thr Thr Pro Met Trp Trp Thr Pro           
            125                 130                 135                   

agc gcc gac tac atg ttc ccc acc gag gat gag ctg ggc ctg ctg atg        483
Ser Ala Asp Tyr Met Phe Pro Thr Glu Asp Glu Leu Gly Leu Leu Met           
        140                 145                 150                       

gtg gcc cct ggc aga ttc aac gag ggc cag tac aga cgg ctg gtg tcc        531
Val Ala Pro Gly Arg Phe Asn Glu Gly Gln Tyr Arg Arg Leu Val Ser           
    155                 160                 165                           

gtg gac ggc gtg aac atc ctg acc gac ttc atg gtg gct ctg cct gag        579
Val Asp Gly Val Asn Ile Leu Thr Asp Phe Met Val Ala Leu Pro Glu           
170                 175                 180                 185           

ggc cag gaa tgc ccc ttc gcc aga gtg gac cag cac aga acc tac aag        627
Gly Gln Glu Cys Pro Phe Ala Arg Val Asp Gln His Arg Thr Tyr Lys           
                190                 195                 200               

ttc ggc gcc tgc tgg aac gac gag agc ttc aga cgg ggc gtg gac gtg        675
Phe Gly Ala Cys Trp Asn Asp Glu Ser Phe Arg Arg Gly Val Asp Val           
            205                 210                 215                   

atg aga ttc ctg acc cca ttc tac cag cag ccc ccc cac aga gaa gtc        723
Met Arg Phe Leu Thr Pro Phe Tyr Gln Gln Pro Pro His Arg Glu Val           
        220                 225                 230                       

gtg aac tac tgg tat aga aag aac ggc aga acc ctg ccc aga gcc tac        771
Val Asn Tyr Trp Tyr Arg Lys Asn Gly Arg Thr Leu Pro Arg Ala Tyr           
    235                 240                 245                           

gcc gct gct aca cct tac gcc atc gac ccc gcc aga cct tct gcc ggc        819
Ala Ala Ala Thr Pro Tyr Ala Ile Asp Pro Ala Arg Pro Ser Ala Gly           
250                 255                 260                 265           

tct ccc aga cca aga ccc agg cct aga cct aga ccc aag cca gag cct        867
Ser Pro Arg Pro Arg Pro Arg Pro Arg Pro Arg Pro Lys Pro Glu Pro           
                270                 275                 280               

gcc cca gtg aca cca gct cct cca ggc aga ctg cca gag cca gcc aca        915
Ala Pro Val Thr Pro Ala Pro Pro Gly Arg Leu Pro Glu Pro Ala Thr           
            285                 290                 295                   

aga gat cac gct gct ggc ggc cac cct acc cct aga cct cca aga cct        963
Arg Asp His Ala Ala Gly Gly His Pro Thr Pro Arg Pro Pro Arg Pro           
        300                 305                 310                       

gag aca ccc cac aga ccc ttc gcc cct cca gct gtg gtg cct tct gga       1011
Glu Thr Pro His Arg Pro Phe Ala Pro Pro Ala Val Val Pro Ser Gly           
    315                 320                 325                           

tgg cct cag cct gcc gag ccc ttc cag cct aga act cct gct gct ccc       1059
Trp Pro Gln Pro Ala Glu Pro Phe Gln Pro Arg Thr Pro Ala Ala Pro           
330                 335                 340                 345           

ggc gtg tgt cga cac aga tcc gtg atc gtg ggc acc ggc aca gct atg       1107
Gly Val Cys Arg His Arg Ser Val Ile Val Gly Thr Gly Thr Ala Met           
                350                 355                 360               

gga gca ctg ctc gtg ggc gtg tgc gtg tac atc ttc ttc aga ctg aga       1155
Gly Ala Leu Leu Val Gly Val Cys Val Tyr Ile Phe Phe Arg Leu Arg           
            365                 370                 375                   

ggc gcc aag ggc tac agg ctg ctg gga ggc cct gct gac aca gac gag       1203
Gly Ala Lys Gly Tyr Arg Leu Leu Gly Gly Pro Ala Asp Thr Asp Glu           
        380                 385                 390                       

ctg aag gct cag cct ggc ccc tgaagaattc gagccaaagc tttgggtcga          1254
Leu Lys Ala Gln Pro Gly Pro                                               
    395                 400                                               

caccgccatc atcatcatca tcattaggcg gccgctctag agtttaaacg atatcgtcga     1314

caccgctagg aattcgagcc aaagctttgg gaggcggccg ctctagagtt taaac          1369


<210> 24
<211> 400
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 24
Met Leu Leu Ala Ala Leu Leu Ala Ala Leu Val Ala Arg Thr Thr Leu 
1               5                   10                  15      


Gly Ala Asp Val Asp Ala Val Pro Ala Pro Thr Phe Pro Pro Pro Ala 
            20                  25                  30          


Tyr Pro Tyr Thr Glu Ser Trp Gln Leu Thr Leu Thr Thr Val Pro Ser 
        35                  40                  45              


Pro Phe Val Gly Pro Ala Asp Val Tyr His Thr Arg Pro Leu Glu Asp 
    50                  55                  60                  


Pro Cys Gly Val Val Ala Leu Ile Ser Asp Pro Gln Val Asp Arg Leu 
65                  70                  75                  80  


Leu Asn Glu Ala Val Ala His Arg Arg Pro Thr Tyr Arg Ala His Val 
                85                  90                  95      


Ala Trp Tyr Arg Ile Ala Asp Gly Cys Ala His Leu Leu Tyr Phe Ile 
            100                 105                 110         


Glu Tyr Ala Asp Cys Asp Pro Arg Gln Ile Phe Gly Arg Cys Arg Arg 
        115                 120                 125             


Arg Thr Thr Pro Met Trp Trp Thr Pro Ser Ala Asp Tyr Met Phe Pro 
    130                 135                 140                 


Thr Glu Asp Glu Leu Gly Leu Leu Met Val Ala Pro Gly Arg Phe Asn 
145                 150                 155                 160 


Glu Gly Gln Tyr Arg Arg Leu Val Ser Val Asp Gly Val Asn Ile Leu 
                165                 170                 175     


Thr Asp Phe Met Val Ala Leu Pro Glu Gly Gln Glu Cys Pro Phe Ala 
            180                 185                 190         


Arg Val Asp Gln His Arg Thr Tyr Lys Phe Gly Ala Cys Trp Asn Asp 
        195                 200                 205             


Glu Ser Phe Arg Arg Gly Val Asp Val Met Arg Phe Leu Thr Pro Phe 
    210                 215                 220                 


Tyr Gln Gln Pro Pro His Arg Glu Val Val Asn Tyr Trp Tyr Arg Lys 
225                 230                 235                 240 


Asn Gly Arg Thr Leu Pro Arg Ala Tyr Ala Ala Ala Thr Pro Tyr Ala 
                245                 250                 255     


Ile Asp Pro Ala Arg Pro Ser Ala Gly Ser Pro Arg Pro Arg Pro Arg 
            260                 265                 270         


Pro Arg Pro Arg Pro Lys Pro Glu Pro Ala Pro Val Thr Pro Ala Pro 
        275                 280                 285             


Pro Gly Arg Leu Pro Glu Pro Ala Thr Arg Asp His Ala Ala Gly Gly 
    290                 295                 300                 


His Pro Thr Pro Arg Pro Pro Arg Pro Glu Thr Pro His Arg Pro Phe 
305                 310                 315                 320 


Ala Pro Pro Ala Val Val Pro Ser Gly Trp Pro Gln Pro Ala Glu Pro 
                325                 330                 335     


Phe Gln Pro Arg Thr Pro Ala Ala Pro Gly Val Ser Arg His Arg Ser 
            340                 345                 350         


Val Ile Val Gly Thr Gly Thr Ala Met Gly Ala Leu Leu Val Gly Val 
        355                 360                 365             


Cys Val Tyr Ile Phe Phe Arg Leu Arg Gly Ala Lys Gly Tyr Arg Leu 
    370                 375                 380                 


Leu Gly Gly Pro Ala Asp Thr Asp Glu Leu Lys Ala Gln Pro Gly Pro 
385                 390                 395                 400 


<210> 25
<211> 1237
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide


<220>
<221> CDS
<222> (41)..(1084)

<400> 25
ctcgaggcta gcccaaagct ttggaagaat catcgccacc atg tgt cgg aga gag         55
                                            Met Cys Arg Arg Glu           
                                            1               5             

agc ctg aga acc ctg ccc tgg ctg ttc tgg gtg ctg ctg agc tgc cct        103
Ser Leu Arg Thr Leu Pro Trp Leu Phe Trp Val Leu Leu Ser Cys Pro           
                10                  15                  20                

aga ctg ctg gaa tac tcc agc tcc agc ttc ccc ttc gcc acc gcc gac        151
Arg Leu Leu Glu Tyr Ser Ser Ser Ser Phe Pro Phe Ala Thr Ala Asp           
            25                  30                  35                    

att gcc gag aag atg tgg gcc gag aac tac gag aca acc agc cct gcc        199
Ile Ala Glu Lys Met Trp Ala Glu Asn Tyr Glu Thr Thr Ser Pro Ala           
        40                  45                  50                        

cct gtg ctg gtg gct gaa ggc gaa caa gtg acc atc ccc tgc acc gtg        247
Pro Val Leu Val Ala Glu Gly Glu Gln Val Thr Ile Pro Cys Thr Val           
    55                  60                  65                            

atg acc cac agc tgg ccc atg gtg tcc atc aga gcc aga ttc tgc aga        295
Met Thr His Ser Trp Pro Met Val Ser Ile Arg Ala Arg Phe Cys Arg           
70                  75                  80                  85            

tcc cac gac ggc agc gac gag ctg atc ctg gat gct gtg aag ggc cac        343
Ser His Asp Gly Ser Asp Glu Leu Ile Leu Asp Ala Val Lys Gly His           
                90                  95                  100               

aga ctg atg aac ggc ctg cag tac aga ctg ccc tac gcc acc tgg aac        391
Arg Leu Met Asn Gly Leu Gln Tyr Arg Leu Pro Tyr Ala Thr Trp Asn           
            105                 110                 115                   

ttc agc cag ctg cac ctg ggc cag atc ttc agc ctg acc ttc aac gtg        439
Phe Ser Gln Leu His Leu Gly Gln Ile Phe Ser Leu Thr Phe Asn Val           
        120                 125                 130                       

tcc acc gac acc gcc ggg atg tac gag tgc gtg ctg aga aac tac agc        487
Ser Thr Asp Thr Ala Gly Met Tyr Glu Cys Val Leu Arg Asn Tyr Ser           
    135                 140                 145                           

cac ggc ctg atc atg cag aga ttc gtg atc ctg acc cag ctg gaa acc        535
His Gly Leu Ile Met Gln Arg Phe Val Ile Leu Thr Gln Leu Glu Thr           
150                 155                 160                 165           

ctg agc aga ccc gac gag cct tgc tgt aca ccc gcc ctg ggc aga tac        583
Leu Ser Arg Pro Asp Glu Pro Cys Cys Thr Pro Ala Leu Gly Arg Tyr           
                170                 175                 180               

agc ctg ggc gat cag atc tgg tcc ccc acc cct tgg aga ctg aga aac        631
Ser Leu Gly Asp Gln Ile Trp Ser Pro Thr Pro Trp Arg Leu Arg Asn           
            185                 190                 195                   

cac gac tgc ggc atg tac aga ggc ttc cag agg aac tac ttc tac atc        679
His Asp Cys Gly Met Tyr Arg Gly Phe Gln Arg Asn Tyr Phe Tyr Ile           
        200                 205                 210                       

ggc aga gcc gac gcc gag gac tgt tgg aag cct gcc tgt ccc gac gag        727
Gly Arg Ala Asp Ala Glu Asp Cys Trp Lys Pro Ala Cys Pro Asp Glu           
    215                 220                 225                           

gaa ccc gac aga tgc tgg acc gtg atc cag aga tac agg ctg ccc ggc        775
Glu Pro Asp Arg Cys Trp Thr Val Ile Gln Arg Tyr Arg Leu Pro Gly           
230                 235                 240                 245           

gac tgc tac aga agc cag cct cac ccc ccc aag ttt ctg cct gtg acc        823
Asp Cys Tyr Arg Ser Gln Pro His Pro Pro Lys Phe Leu Pro Val Thr           
                250                 255                 260               

cct gct cct cct gcc gac atc gac acc ggt atg agc cct tgg gcc acc        871
Pro Ala Pro Pro Ala Asp Ile Asp Thr Gly Met Ser Pro Trp Ala Thr           
            265                 270                 275                   

aga gga atc gcc gcc ttc ctg ggc ttc tgg tct atc ttc acc gtg tgc        919
Arg Gly Ile Ala Ala Phe Leu Gly Phe Trp Ser Ile Phe Thr Val Cys           
        280                 285                 290                       

ttt ctg tgc tac ctg tgt tac ctg cag tgc tgc ggc aga tgg tgc cct        967
Phe Leu Cys Tyr Leu Cys Tyr Leu Gln Cys Cys Gly Arg Trp Cys Pro           
    295                 300                 305                           

aca cct ggc aga ggc aga aga ggc ggc gag gga tac aga agg ctg ccc       1015
Thr Pro Gly Arg Gly Arg Arg Gly Gly Glu Gly Tyr Arg Arg Leu Pro           
310                 315                 320                 325           

acc tac gac agc tac ccc ggc gtg aag aag atg aag cgc gag cag aag       1063
Thr Tyr Asp Ser Tyr Pro Gly Val Lys Lys Met Lys Arg Glu Gln Lys           
                330                 335                 340               

ctg atc tcc gaa gag gac ctg tgaaaccggt atgtctcccg aacaaaaact          1114
Leu Ile Ser Glu Glu Asp Leu                                               
            345                                                           

tatttctgaa gaagatctgc atcatcatca tcatcattga gtttaaacgg atccgatatc     1174

accggtatgt ctcccgaaca aaaacttatt tctgaagaag atctgtgagt ttaaacggat     1234

ccg                                                                   1237


<210> 26
<211> 348
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 26
Met Cys Arg Arg Glu Ser Leu Arg Thr Leu Pro Trp Leu Phe Trp Val 
1               5                   10                  15      


Leu Leu Ser Cys Pro Arg Leu Leu Glu Tyr Ser Ser Ser Ser Phe Pro 
            20                  25                  30          


Phe Ala Thr Ala Asp Ile Ala Glu Lys Met Trp Ala Glu Asn Tyr Glu 
        35                  40                  45              


Thr Thr Ser Pro Ala Pro Val Leu Val Ala Glu Gly Glu Gln Val Thr 
    50                  55                  60                  


Ile Pro Cys Thr Val Met Thr His Ser Trp Pro Met Val Ser Ile Arg 
65                  70                  75                  80  


Ala Arg Phe Cys Arg Ser His Asp Gly Ser Asp Glu Leu Ile Leu Asp 
                85                  90                  95      


Ala Val Lys Gly His Arg Leu Met Asn Gly Leu Gln Tyr Arg Leu Pro 
            100                 105                 110         


Tyr Ala Thr Trp Asn Phe Ser Gln Leu His Leu Gly Gln Ile Phe Ser 
        115                 120                 125             


Leu Thr Phe Asn Val Ser Thr Asp Thr Ala Gly Met Tyr Glu Cys Val 
    130                 135                 140                 


Leu Arg Asn Tyr Ser His Gly Leu Ile Met Gln Arg Phe Val Ile Leu 
145                 150                 155                 160 


Thr Gln Leu Glu Thr Leu Ser Arg Pro Asp Glu Pro Cys Cys Thr Pro 
                165                 170                 175     


Ala Leu Gly Arg Tyr Ser Leu Gly Asp Gln Ile Trp Ser Pro Thr Pro 
            180                 185                 190         


Trp Arg Leu Arg Asn His Asp Cys Gly Met Tyr Arg Gly Phe Gln Arg 
        195                 200                 205             


Asn Tyr Phe Tyr Ile Gly Arg Ala Asp Ala Glu Asp Cys Trp Lys Pro 
    210                 215                 220                 


Ala Cys Pro Asp Glu Glu Pro Asp Arg Cys Trp Thr Val Ile Gln Arg 
225                 230                 235                 240 


Tyr Arg Leu Pro Gly Asp Cys Tyr Arg Ser Gln Pro His Pro Pro Lys 
                245                 250                 255     


Phe Leu Pro Val Thr Pro Ala Pro Pro Ala Asp Ile Asp Thr Gly Met 
            260                 265                 270         


Ser Pro Trp Ala Thr Arg Gly Ile Ala Ala Phe Leu Gly Phe Trp Ser 
        275                 280                 285             


Ile Phe Thr Val Cys Phe Leu Cys Tyr Leu Cys Tyr Leu Gln Cys Cys 
    290                 295                 300                 


Gly Arg Trp Cys Pro Thr Pro Gly Arg Gly Arg Arg Gly Gly Glu Gly 
305                 310                 315                 320 


Tyr Arg Arg Leu Pro Thr Tyr Asp Ser Tyr Pro Gly Val Lys Lys Met 
                325                 330                 335     


Lys Arg Glu Gln Lys Leu Ile Ser Glu Glu Asp Leu 
            340                 345             


