                               SEQUENCE LISTING

<110> UNIVERSITY OF SOUTHERN CALIFORNIA
 
<120> AN ELISA-LIKE ASSAY FOR QUANTIFYING ENZYMATIC ACTIVITIES OF 
      MONO-ADP-RIBOSYLTRANSFERASES

<130> 064189-0251

<140> PCT/US2017/053844
<141> 2017-09-27

<150> 62/400,566
<151> 2016-09-27

<160> 26    

<170> PatentIn version 3.5

<210> 1
<211> 188
<212> PRT
<213> Homo sapiens

<400> 1
Lys Cys Phe Ser Arg Thr Val Leu Ala Pro Gly Val Val Leu Ile Val 
1               5                   10                  15      


Gln Gln Gly Asp Leu Ala Arg Leu Pro Val Asp Val Val Val Asn Ala 
            20                  25                  30          


Ser Asn Glu Asp Leu Lys His Tyr Gly Gly Leu Ala Ala Ala Leu Ser 
        35                  40                  45              


Lys Ala Ala Gly Pro Glu Leu Gln Ala Asp Cys Asp Gln Ile Val Lys 
    50                  55                  60                  


Arg Glu Gly Arg Leu Leu Pro Gly Asn Ala Thr Ile Ser Lys Ala Gly 
65                  70                  75                  80  


Lys Leu Pro Tyr His His Val Ile His Ala Val Gly Pro Arg Trp Ser 
                85                  90                  95      


Gly Tyr Glu Ala Pro Arg Cys Val Tyr Leu Leu Arg Arg Ala Val Gln 
            100                 105                 110         


Leu Ser Leu Cys Leu Ala Glu Lys Tyr Lys Tyr Arg Ser Ile Ala Ile 
        115                 120                 125             


Pro Ala Ile Ser Ser Gly Val Phe Gly Phe Pro Leu Gly Arg Cys Val 
    130                 135                 140                 


Glu Thr Ile Val Ser Ala Ile Lys Glu Asn Phe Gln Phe Lys Lys Asp 
145                 150                 155                 160 


Gly His Cys Leu Lys Glu Ile Tyr Leu Val Asp Val Ser Glu Lys Thr 
                165                 170                 175     


Val Glu Ala Phe Ala Glu Ala Val Lys Thr Val Phe 
            180                 185             


<210> 2
<211> 172
<212> PRT
<213> Homo sapiens

<400> 2
Asp Ser Gly Val Tyr Glu Met Lys Ile Gly Ser Ile Ile Phe Gln Val 
1               5                   10                  15      


Ala Ser Gly Asp Ile Thr Lys Glu Glu Ala Asp Val Ile Val Asn Ser 
            20                  25                  30          


Thr Ser Asn Ser Phe Asn Leu Lys Ala Gly Val Ser Lys Ala Ile Leu 
        35                  40                  45              


Glu Cys Ala Gly Gln Asn Val Glu Arg Glu Cys Ser Gln Gln Ala Gln 
    50                  55                  60                  


Gln Arg Lys Asn Asp Tyr Ile Ile Thr Gly Gly Gly Phe Leu Arg Cys 
65                  70                  75                  80  


Lys Asn Ile Ile His Val Ile Gly Gly Asn Asp Val Lys Ser Ser Val 
                85                  90                  95      


Ser Ser Val Leu Gln Glu Cys Glu Lys Lys Asn Tyr Ser Ser Ile Cys 
            100                 105                 110         


Leu Pro Ala Ile Gly Thr Gly Asn Ala Lys Gln His Pro Asp Lys Val 
        115                 120                 125             


Ala Glu Ala Ile Ile Asp Ala Ile Glu Asp Phe Val Gln Lys Gly Ser 
    130                 135                 140                 


Ala Gln Ser Val Lys Lys Val Lys Val Val Ile Phe Leu Pro Gln Val 
145                 150                 155                 160 


Leu Asp Val Phe Tyr Ala Asn Met Lys Lys Arg Glu 
                165                 170         


<210> 3
<211> 194
<212> PRT
<213> Homo sapiens

<400> 3
Ser Ala Glu Leu Asp Tyr Gln Asp Pro Asp Ala Thr Ser Leu Lys Tyr 
1               5                   10                  15      


Val Ser Gly Asp Val Thr His Pro Gln Ala Gly Ala Glu Asp Ala Leu 
            20                  25                  30          


Ile Val His Cys Val Asp Asp Ser Gly His Trp Gly Arg Gly Gly Leu 
        35                  40                  45              


Phe Thr Ala Leu Glu Lys Arg Ser Ala Glu Pro Arg Lys Ile Tyr Glu 
    50                  55                  60                  


Leu Ala Gly Lys Met Lys Asp Leu Ser Leu Gly Gly Val Leu Leu Phe 
65                  70                  75                  80  


Pro Val Asp Asp Lys Glu Ser Arg Asn Lys Gly Gln Asp Leu Leu Ala 
                85                  90                  95      


Leu Ile Val Ala Gln His Arg Asp Arg Ser Asn Val Leu Ser Gly Ile 
            100                 105                 110         


Lys Met Ala Ala Leu Glu Glu Gly Leu Lys Lys Ile Phe Leu Ala Ala 
        115                 120                 125             


Lys Lys Lys Lys Ala Ser Val His Leu Pro Arg Ile Gly His Ala Thr 
    130                 135                 140                 


Lys Gly Phe Asn Trp Tyr Gly Thr Glu Arg Leu Ile Arg Lys His Leu 
145                 150                 155                 160 


Ala Ala Arg Gly Ile Pro Thr Tyr Ile Tyr Tyr Phe Pro Arg Ser Lys 
                165                 170                 175     


Ser Ala Val Leu His Ala Gln Ser Ser Ser Ser Ser Ser Arg Gln Leu 
            180                 185                 190         


Val Pro 
        


<210> 4
<211> 151
<212> PRT
<213> Homo sapiens

<400> 4
Ala Ser Ser Leu Asn Glu Asp Pro Glu Gly Ser Arg Ile Thr Tyr Val 
1               5                   10                  15      


Lys Gly Asp Leu Phe Ala Cys Pro Lys Thr Asp Ser Leu Ala His Cys 
            20                  25                  30          


Ile Ser Glu Asp Cys Arg Met Gly Ala Gly Ile Ala Val Leu Phe Lys 
        35                  40                  45              


Lys Lys Phe Gly Gly Val Gln Glu Leu Leu Asn Gln Gln Lys Lys Ser 
    50                  55                  60                  


Gly Glu Val Ala Val Leu Lys Arg Asp Gly Arg Tyr Ile Tyr Tyr Leu 
65                  70                  75                  80  


Ile Thr Lys Lys Arg Ala Ser His Lys Pro Thr Tyr Glu Asn Leu Gln 
                85                  90                  95      


Lys Ser Leu Glu Ala Met Lys Ser His Cys Leu Lys Asn Gly Val Thr 
            100                 105                 110         


Asp Leu Ser Met Pro Arg Ile Gly Cys Gly Leu Asp Arg Leu Gln Trp 
        115                 120                 125             


Glu Asn Val Ser Ala Met Ile Glu Glu Val Phe Glu Ala Thr Asp Ile 
    130                 135                 140                 


Lys Ile Thr Val Tyr Thr Leu 
145                 150     


<210> 5
<211> 6
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      6xHis tag

<400> 5
His His His His His His 
1               5       


<210> 6
<211> 58
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 6
caccatcatc atcatcatat tgagggtcgc gatatgaagc agcagaattt ctgtgtgg         58


<210> 7
<211> 55
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 7
aagggcatcg gtcgacttat tattttctaa acgtaataag gtactctggg tatgc            55


<210> 8
<211> 55
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 8
tttctattgc tacaaacgca tacgctatgc accatcatca tcatcatatt gaggg            55


<210> 9
<211> 49
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 9
ctcaagggca tcggtcgact tattaactaa ccaaattgcc gtttgcacg                   49


<210> 10
<211> 72
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 10
tctagaaata attttgttta actttaagaa ggagatatac catgcaccat catcatcatc       60

atattgaggg tc                                                           72


<210> 11
<211> 40
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 11
ctcgagttat tattttctaa acgtaataag gtactctggg                             40


<210> 12
<211> 71
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 12
gtggtgctcg agttattaag cgtaatctgg aacatcgtat gggtaactga cgagatttcc       60

attagccctt c                                                            71


<210> 13
<211> 54
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 13
caccatcacc atcacattga aggccgtaat cttcctgaac actggactga catg             54


<210> 14
<211> 53
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 14
ctcaagggca tcggtcgact tattaagccg tgaaagttat gagatattct ggg              53


<210> 15
<211> 69
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 15
tctagaaata attttgttta actttaagaa ggagatatac catgggccat caccatcacc       60

atcacattg                                                               69


<210> 16
<211> 55
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 16
gtggtggtgg tggtgctcga gttattaagc cgtgaaagtt atgagatatt ctggg            55


<210> 17
<211> 654
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 17
atgcaccatc atcatcatca tattgagggt cgcgggaaaa catcatggga aaaaggaagc       60

ctggtgtccc cgggaggcct gcagatgctg ttggtgaaag agggtgtgca gaatgctaag      120

accgatgttg ttgtcaactc cgttcccttg gatctcgtgc ttagtagagg gcctctttct      180

aagtccctct tggaaaaagc tggaccagag ctccaggagg aattggacac agttggacaa      240

ggggtggctg tcagcatggg cacagtgctc aaaaccagca gctggaatct ggactgtcgc      300

tatgtgcttc acgtggtagc tccggagtgg agaaatggta gcacatcttc actcaagata      360

atggaagaca taatcagaga atgtatggag atcactgaga gcttgtcctt aaaatcaatt      420

gcatttccag caataggaac aggaaacttg ggatttccta aaaacatatt cgctgaatta      480

atcatttcag aggtgttcaa atttagtagc aagaatcagc tgaaaacttt acaagaggtt      540

cactttctgc tgcacccgag tgatcatgaa aatattcagg cattttcaga tgaatttgcc      600

agaagggcta atggaaatct cgtcagttac ccatacgatg ttccagatta cgct            654


<210> 18
<211> 218
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 18
Met His His His His His His Ile Glu Gly Arg Gly Lys Thr Ser Trp 
1               5                   10                  15      


Glu Lys Gly Ser Leu Val Ser Pro Gly Gly Leu Gln Met Leu Leu Val 
            20                  25                  30          


Lys Glu Gly Val Gln Asn Ala Lys Thr Asp Val Val Val Asn Ser Val 
        35                  40                  45              


Pro Leu Asp Leu Val Leu Ser Arg Gly Pro Leu Ser Lys Ser Leu Leu 
    50                  55                  60                  


Glu Lys Ala Gly Pro Glu Leu Gln Glu Glu Leu Asp Thr Val Gly Gln 
65                  70                  75                  80  


Gly Val Ala Val Ser Met Gly Thr Val Leu Lys Thr Ser Ser Trp Asn 
                85                  90                  95      


Leu Asp Cys Arg Tyr Val Leu His Val Val Ala Pro Glu Trp Arg Asn 
            100                 105                 110         


Gly Ser Thr Ser Ser Leu Lys Ile Met Glu Asp Ile Ile Arg Glu Cys 
        115                 120                 125             


Met Glu Ile Thr Glu Ser Leu Ser Leu Lys Ser Ile Ala Phe Pro Ala 
    130                 135                 140                 


Ile Gly Thr Gly Asn Leu Gly Phe Pro Lys Asn Ile Phe Ala Glu Leu 
145                 150                 155                 160 


Ile Ile Ser Glu Val Phe Lys Phe Ser Ser Lys Asn Gln Leu Lys Thr 
                165                 170                 175     


Leu Gln Glu Val His Phe Leu Leu His Pro Ser Asp His Glu Asn Ile 
            180                 185                 190         


Gln Ala Phe Ser Asp Glu Phe Ala Arg Arg Ala Asn Gly Asn Leu Val 
        195                 200                 205             


Ser Tyr Pro Tyr Asp Val Pro Asp Tyr Ala 
    210                 215             


<210> 19
<211> 234
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 19
Met His His His His His His Ile Glu Gly Arg Ile Gln Gln Gln Lys 
1               5                   10                  15      


Thr Gln Asp Glu Met Lys Glu Asn Ile Ile Phe Leu Lys Cys Pro Val 
            20                  25                  30          


Pro Pro Thr Gln Glu Leu Leu Asp Gln Lys Lys Gln Phe Glu Lys Cys 
        35                  40                  45              


Gly Leu Gln Val Leu Lys Val Glu Lys Ile Asp Asn Glu Val Leu Met 
    50                  55                  60                  


Ala Ala Phe Gln Arg Lys Lys Lys Met Met Glu Glu Lys Leu His Arg 
65                  70                  75                  80  


Gln Pro Val Ser His Arg Leu Phe Gln Gln Val Pro Tyr Gln Phe Cys 
                85                  90                  95      


Asn Val Val Cys Arg Val Gly Phe Gln Arg Met Tyr Ser Thr Pro Cys 
            100                 105                 110         


Asp Pro Lys Tyr Gly Ala Gly Ile Tyr Phe Thr Lys Asn Leu Lys Asn 
        115                 120                 125             


Leu Ala Glu Lys Ala Lys Lys Ile Ser Ala Ala Asp Lys Leu Ile Tyr 
    130                 135                 140                 


Val Phe Glu Ala Glu Val Leu Thr Gly Phe Phe Cys Gln Gly His Pro 
145                 150                 155                 160 


Leu Asn Ile Val Pro Pro Pro Leu Ser Pro Gly Ala Ile Asp Gly His 
                165                 170                 175     


Asp Ser Val Val Asp Asn Val Ser Ser Pro Glu Thr Phe Val Ile Phe 
            180                 185                 190         


Ser Gly Met Gln Ala Ile Pro Gln Tyr Leu Trp Thr Cys Thr Gln Glu 
        195                 200                 205             


Tyr Val Gln Ser Gln Asp Tyr Ser Ser Gly Pro Met Arg Pro Phe Ala 
    210                 215                 220                 


Gln His Pro Trp Arg Gly Phe Ala Ser Gly 
225                 230                 


<210> 20
<211> 606
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 20
atgcaccatc atcatcatca tattgagggt cgcgatatga agcagcagaa tttctgtgtg       60

gtggagctgc tgcctagtga tcctgagtac aacacggtgg caagcaagtt taatcagacc      120

tgctcacact tcagaataga gaagattgag aggatccaga atccagatct ctggaatagc      180

taccaggcaa agaaaaaaac tatggatgcc aagaatggcc agacaatgaa tgagaagcaa      240

ctcttccatg ggacagatgc cggctccgtg ccacacgtca atcgaaatgg ctttaaccgc      300

agctatgccg gaaagaatgc tgtggcatat ggaaagggaa cctattttgc tgtcaatgcc      360

aattattctg ccaatgatac gtactccaga ccagatgcaa atgggagaaa gcatgtgtat      420

tatgtgcgag tacttactgg aatctataca catggaaatc attcattaat tgtgcctcct      480

tcaaagaacc ctcaaaatcc tactgacctg tatgacactg tcacagataa tgtgcaccat      540

ccaagtttat ttgtggcatt ttatgactac caagcatacc cagagtacct tattacgttt      600

agaaaa                                                                 606


<210> 21
<211> 202
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 21
Met His His His His His His Ile Glu Gly Arg Asp Met Lys Gln Gln 
1               5                   10                  15      


Asn Phe Cys Val Val Glu Leu Leu Pro Ser Asp Pro Glu Tyr Asn Thr 
            20                  25                  30          


Val Ala Ser Lys Phe Asn Gln Thr Cys Ser His Phe Arg Ile Glu Lys 
        35                  40                  45              


Ile Glu Arg Ile Gln Asn Pro Asp Leu Trp Asn Ser Tyr Gln Ala Lys 
    50                  55                  60                  


Lys Lys Thr Met Asp Ala Lys Asn Gly Gln Thr Met Asn Glu Lys Gln 
65                  70                  75                  80  


Leu Phe His Gly Thr Asp Ala Gly Ser Val Pro His Val Asn Arg Asn 
                85                  90                  95      


Gly Phe Asn Arg Ser Tyr Ala Gly Lys Asn Ala Val Ala Tyr Gly Lys 
            100                 105                 110         


Gly Thr Tyr Phe Ala Val Asn Ala Asn Tyr Ser Ala Asn Asp Thr Tyr 
        115                 120                 125             


Ser Arg Pro Asp Ala Asn Gly Arg Lys His Val Tyr Tyr Val Arg Val 
    130                 135                 140                 


Leu Thr Gly Ile Tyr Thr His Gly Asn His Ser Leu Ile Val Pro Pro 
145                 150                 155                 160 


Ser Lys Asn Pro Gln Asn Pro Thr Asp Leu Tyr Asp Thr Val Thr Asp 
                165                 170                 175     


Asn Val His His Pro Ser Leu Phe Val Ala Phe Tyr Asp Tyr Gln Ala 
            180                 185                 190         


Tyr Pro Glu Tyr Leu Ile Thr Phe Arg Lys 
        195                 200         


<210> 22
<211> 630
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 22
atgggccatc accatcacca tcacattgaa ggccgtaatc ttcctgaaca ctggactgac       60

atgaatcatc agctgttttg catggtccag ctagagccag gacaatcaga atataatacc      120

ataaaggaca agttcacccg aacttgttct tcctacgcaa tagagaagat tgagaggata      180

cagaatgcat ttctctggca gagctaccag gtaaagaaaa ggcaaatgga tatcaagaat      240

gaccataaga ataatgagag actcctcttc catgggacag atgcagactc agtgccatat      300

gtcaatcagc acggctttaa tagaagttgt gctgggaaaa atgctgtatc ctatggaaaa      360

ggaacctatt ttgctgtgga tgccagttat tctgccaagg acacctactc caagccagac      420

agcaatggga gaaagcacat gtacgttgtg cgagtactta ctggagtctt cacaaaggga      480

cgtgcaggat tagtcacccc tccacccaag aatcctcaca atcccacaga tctctttgac      540

tcagtgacaa acaatacacg atctccaaag ctatttgtgg tattctttga taatcaggct      600

tacccagaat atctcataac tttcacggct                                       630


<210> 23
<211> 210
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 23
Met Gly His His His His His His Ile Glu Gly Arg Asn Leu Pro Glu 
1               5                   10                  15      


His Trp Thr Asp Met Asn His Gln Leu Phe Cys Met Val Gln Leu Glu 
            20                  25                  30          


Pro Gly Gln Ser Glu Tyr Asn Thr Ile Lys Asp Lys Phe Thr Arg Thr 
        35                  40                  45              


Cys Ser Ser Tyr Ala Ile Glu Lys Ile Glu Arg Ile Gln Asn Ala Phe 
    50                  55                  60                  


Leu Trp Gln Ser Tyr Gln Val Lys Lys Arg Gln Met Asp Ile Lys Asn 
65                  70                  75                  80  


Asp His Lys Asn Asn Glu Arg Leu Leu Phe His Gly Thr Asp Ala Asp 
                85                  90                  95      


Ser Val Pro Tyr Val Asn Gln His Gly Phe Asn Arg Ser Cys Ala Gly 
            100                 105                 110         


Lys Asn Ala Val Ser Tyr Gly Lys Gly Thr Tyr Phe Ala Val Asp Ala 
        115                 120                 125             


Ser Tyr Ser Ala Lys Asp Thr Tyr Ser Lys Pro Asp Ser Asn Gly Arg 
    130                 135                 140                 


Lys His Met Tyr Val Val Arg Val Leu Thr Gly Val Phe Thr Lys Gly 
145                 150                 155                 160 


Arg Ala Gly Leu Val Thr Pro Pro Pro Lys Asn Pro His Asn Pro Thr 
                165                 170                 175     


Asp Leu Phe Asp Ser Val Thr Asn Asn Thr Arg Ser Pro Lys Leu Phe 
            180                 185                 190         


Val Val Phe Phe Asp Asn Gln Ala Tyr Pro Glu Tyr Leu Ile Thr Phe 
        195                 200                 205             


Thr Ala 
    210 


<210> 24
<211> 861
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 24
atgggccatc accatcacca tcacattgaa ggccgtggct gggcggccgc cagggaggcg       60

gcgggccgcg acatgctggc cgccgacctc cggtgcagcc tcttcgcctc ggccctgcag      120

agctacaagc gcgactcggt gctgcggccc ttccccgcgt cctacgcccg cggcgactgt      180

aaggactttg aagccctgct tgcagatgcc agcaagttac ctaacctgaa agaacttctc      240

cagtcctccg gagacaacca caaacgggcc tgggacctgg tgagctggat tttatcctca      300

aaggtcctga caatccacag tgcagggaag gcagagtttg aaaagatcca aaagctgact      360

ggggctcctc acacgcctgt tcctgcaccg gacttcctgt ttgaaattga gtactttgac      420

ccagccaacg ccaaatttta tgagaccaaa ggagaacgag acctaatcta tgcatttcat      480

ggtagccgcc tagaaaactt ccattccatt atccacaatg gcctgcactg ccatctgaac      540

aagacatcct tgttcggaga ggggacctac ctcaccagtg acttaagcct ggccctcata      600

tacagccccc atggccatgg gtggcagcac agcctcctcg gccccatcct tagctgtgtg      660

gccgtgtgtg aggtcattga ccatccggac gtcaagtgcc aaaccaagaa gaaggattcc      720

aaggagatag atcgcagacg agcgagaatc aaacatagtg aagggggaga catccctccc      780

aagtacttcg tggtcaccaa taaccagctg ctgcgagtga agtacctcct ggtgtattca      840

cagaagccac ccaagagggc t                                                861


<210> 25
<211> 287
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 25
Met Gly His His His His His His Ile Glu Gly Arg Gly Trp Ala Ala 
1               5                   10                  15      


Ala Arg Glu Ala Ala Gly Arg Asp Met Leu Ala Ala Asp Leu Arg Cys 
            20                  25                  30          


Ser Leu Phe Ala Ser Ala Leu Gln Ser Tyr Lys Arg Asp Ser Val Leu 
        35                  40                  45              


Arg Pro Phe Pro Ala Ser Tyr Ala Arg Gly Asp Cys Lys Asp Phe Glu 
    50                  55                  60                  


Ala Leu Leu Ala Asp Ala Ser Lys Leu Pro Asn Leu Lys Glu Leu Leu 
65                  70                  75                  80  


Gln Ser Ser Gly Asp Asn His Lys Arg Ala Trp Asp Leu Val Ser Trp 
                85                  90                  95      


Ile Leu Ser Ser Lys Val Leu Thr Ile His Ser Ala Gly Lys Ala Glu 
            100                 105                 110         


Phe Glu Lys Ile Gln Lys Leu Thr Gly Ala Pro His Thr Pro Val Pro 
        115                 120                 125             


Ala Pro Asp Phe Leu Phe Glu Ile Glu Tyr Phe Asp Pro Ala Asn Ala 
    130                 135                 140                 


Lys Phe Tyr Glu Thr Lys Gly Glu Arg Asp Leu Ile Tyr Ala Phe His 
145                 150                 155                 160 


Gly Ser Arg Leu Glu Asn Phe His Ser Ile Ile His Asn Gly Leu His 
                165                 170                 175     


Cys His Leu Asn Lys Thr Ser Leu Phe Gly Glu Gly Thr Tyr Leu Thr 
            180                 185                 190         


Ser Asp Leu Ser Leu Ala Leu Ile Tyr Ser Pro His Gly His Gly Trp 
        195                 200                 205             


Gln His Ser Leu Leu Gly Pro Ile Leu Ser Cys Val Ala Val Cys Glu 
    210                 215                 220                 


Val Ile Asp His Pro Asp Val Lys Cys Gln Thr Lys Lys Lys Asp Ser 
225                 230                 235                 240 


Lys Glu Ile Asp Arg Arg Arg Ala Arg Ile Lys His Ser Glu Gly Gly 
                245                 250                 255     


Asp Ile Pro Pro Lys Tyr Phe Val Val Thr Asn Asn Gln Leu Leu Arg 
            260                 265                 270         


Val Lys Tyr Leu Leu Val Tyr Ser Gln Lys Pro Pro Lys Arg Ala 
        275                 280                 285         


<210> 26
<211> 5893
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 26
atccggatat agttcctcct ttcagcaaaa aacccctcaa gacccgttta gaggccccaa       60

ggggttatgc tagttattgc tcagcggtgg cagcagccaa ctcagcttcc tttcgggctt      120

tgttagcagc cggatctcag tggtggtggt ggtggtgctc gagttattaa gcgtaatctg      180

gaacatcgta tgggtaactg acgagatttc cattagccct tctggcaaat tcatctgaaa      240

atgcctgaat attttcatga tcactcgggt gcagcagaaa gtgaacctct tgtaaagttt      300

tcagctgatt cttgctacta aatttgaaca cctctgaaat gattaattca gcgaatatgt      360

ttttaggaaa tcccaagttt cctgttccta ttgctggaaa tgcaattgat tttaaggaca      420

agctctcagt gatctccata cattctctga ttatgtcttc cattatcttg agtgaagatg      480

tgctaccatt tctccactcc ggagctacca cgtgaagcac atagcgacag tccagattcc      540

agctgctggt tttgagcact gtgcccatgc tgacagccac cccttgtcca actgtgtcca      600

attcctcctg gagctctggt ccagcttttt ccaagaggga cttagaaaga ggccctctac      660

taagcacgag atccaaggga acggagttga caacaacatc ggtcttagca ttctgcacac      720

cctctttcac caacagcatc tgcaggcctc ccggggacac caggcttcct ttttcccatg      780

atgttttccc gcgaccctca atatgatgat gatgatggtg catggtatat ctccttctta      840

aagttaaaca aaattatttc tagaggggaa ttgttatccg ctcacaattc ccctatagtg      900

agtcgtatta atttcgcggg atcgagatct cgatcctcta cgccggacgc atcgtggccg      960

gcatcaccgg cgccacaggt gcggttgctg gcgcctatat cgccgacatc accgatgggg     1020

aagatcgggc tcgccacttc gggctcatga gcgcttgttt cggcgtgggt atggtggcag     1080

gccccgtggc cgggggactg ttgggcgcca tctccttgca tgcaccattc cttgcggcgg     1140

cggtgctcaa cggcctcaac ctactactgg gctgcttcct aatgcaggag tcgcataagg     1200

gagagcgtcg agatcccgga caccatcgaa tggcgcaaaa cctttcgcgg tatggcatga     1260

tagcgcccgg aagagagtca attcagggtg gtgaatgtga aaccagtaac gttatacgat     1320

gtcgcagagt atgccggtgt ctcttatcag accgtttccc gcgtggtgaa ccaggccagc     1380

cacgtttctg cgaaaacgcg ggaaaaagtg gaagcggcga tggcggagct gaattacatt     1440

cccaaccgcg tggcacaaca actggcgggc aaacagtcgt tgctgattgg cgttgccacc     1500

tccagtctgg ccctgcacgc gccgtcgcaa attgtcgcgg cgattaaatc tcgcgccgat     1560

caactgggtg ccagcgtggt ggtgtcgatg gtagaacgaa gcggcgtcga agcctgtaaa     1620

gcggcggtgc acaatcttct cgcgcaacgc gtcagtgggc tgatcattaa ctatccgctg     1680

gatgaccagg atgccattgc tgtggaagct gcctgcacta atgttccggc gttatttctt     1740

gatgtctctg accagacacc catcaacagt attattttct cccatgaaga cggtacgcga     1800

ctgggcgtgg agcatctggt cgcattgggt caccagcaaa tcgcgctgtt agcgggccca     1860

ttaagttctg tctcggcgcg tctgcgtctg gctggctggc ataaatatct cactcgcaat     1920

caaattcagc cgatagcgga acgggaaggc gactggagtg ccatgtccgg ttttcaacaa     1980

accatgcaaa tgctgaatga gggcatcgtt cccactgcga tgctggttgc caacgatcag     2040

atggcgctgg gcgcaatgcg cgccattacc gagtccgggc tgcgcgttgg tgcggatatc     2100

tcggtagtgg gatacgacga taccgaagac agctcatgtt atatcccgcc gttaaccacc     2160

atcaaacagg attttcgcct gctggggcaa accagcgtgg accgcttgct gcaactctct     2220

cagggccagg cggtgaaggg caatcagctg ttgcccgtct cactggtgaa aagaaaaacc     2280

accctggcgc ccaatacgca aaccgcctct ccccgcgcgt tggccgattc attaatgcag     2340

ctggcacgac aggtttcccg actggaaagc gggcagtgag cgcaacgcaa ttaatgtaag     2400

ttagctcact cattaggcac cgggatctcg accgatgccc ttgagagcct tcaacccagt     2460

cagctccttc cggtgggcgc ggggcatgac tatcgtcgcc gcacttatga ctgtcttctt     2520

tatcatgcaa ctcgtaggac aggtgccggc agcgctctgg gtcattttcg gcgaggaccg     2580

ctttcgctgg agcgcgacga tgatcggcct gtcgcttgcg gtattcggaa tcttgcacgc     2640

cctcgctcaa gccttcgtca ctggtcccgc caccaaacgt ttcggcgaga agcaggccat     2700

tatcgccggc atggcggccc cacgggtgcg catgatcgtg ctcctgtcgt tgaggacccg     2760

gctaggctgg cggggttgcc ttactggtta gcagaatgaa tcaccgatac gcgagcgaac     2820

gtgaagcgac tgctgctgca aaacgtctgc gacctgagca acaacatgaa tggtcttcgg     2880

tttccgtgtt tcgtaaagtc tggaaacgcg gaagtcagcg ccctgcacca ttatgttccg     2940

gatctgcatc gcaggatgct gctggctacc ctgtggaaca cctacatctg tattaacgaa     3000

gcgctggcat tgaccctgag tgatttttct ctggtcccgc cgcatccata ccgccagttg     3060

tttaccctca caacgttcca gtaaccgggc atgttcatca tcagtaaccc gtatcgtgag     3120

catcctctct cgtttcatcg gtatcattac ccccatgaac agaaatcccc cttacacgga     3180

ggcatcagtg accaaacagg aaaaaaccgc ccttaacatg gcccgcttta tcagaagcca     3240

gacattaacg cttctggaga aactcaacga gctggacgcg gatgaacagg cagacatctg     3300

tgaatcgctt cacgaccacg ctgatgagct ttaccgcagc tgcctcgcgc gtttcggtga     3360

tgacggtgaa aacctctgac acatgcagct cccggagacg gtcacagctt gtctgtaagc     3420

ggatgccggg agcagacaag cccgtcaggg cgcgtcagcg ggtgttggcg ggtgtcgggg     3480

cgcagccatg acccagtcac gtagcgatag cggagtgtat actggcttaa ctatgcggca     3540

tcagagcaga ttgtactgag agtgcaccat atatgcggtg tgaaataccg cacagatgcg     3600

taaggagaaa ataccgcatc aggcgctctt ccgcttcctc gctcactgac tcgctgcgct     3660

cggtcgttcg gctgcggcga gcggtatcag ctcactcaaa ggcggtaata cggttatcca     3720

cagaatcagg ggataacgca ggaaagaaca tgtgagcaaa aggccagcaa aaggccagga     3780

accgtaaaaa ggccgcgttg ctggcgtttt tccataggct ccgcccccct gacgagcatc     3840

acaaaaatcg acgctcaagt cagaggtggc gaaacccgac aggactataa agataccagg     3900

cgtttccccc tggaagctcc ctcgtgcgct ctcctgttcc gaccctgccg cttaccggat     3960

acctgtccgc ctttctccct tcgggaagcg tggcgctttc tcatagctca cgctgtaggt     4020

atctcagttc ggtgtaggtc gttcgctcca agctgggctg tgtgcacgaa ccccccgttc     4080

agcccgaccg ctgcgcctta tccggtaact atcgtcttga gtccaacccg gtaagacacg     4140

acttatcgcc actggcagca gccactggta acaggattag cagagcgagg tatgtaggcg     4200

gtgctacaga gttcttgaag tggtggccta actacggcta cactagaagg acagtatttg     4260

gtatctgcgc tctgctgaag ccagttacct tcggaaaaag agttggtagc tcttgatccg     4320

gcaaacaaac caccgctggt agcggtggtt tttttgtttg caagcagcag attacgcgca     4380

gaaaaaaagg atctcaagaa gatcctttga tcttttctac ggggtctgac gctcagtgga     4440

acgaaaactc acgttaaggg attttggtca tgaacaataa aactgtctgc ttacataaac     4500

agtaatacaa ggggtgttat gagccatatt caacgggaaa cgtcttgctc taggccgcga     4560

ttaaattcca acatggatgc tgatttatat gggtataaat gggctcgcga taatgtcggg     4620

caatcaggtg cgacaatcta tcgattgtat gggaagcccg atgcgccaga gttgtttctg     4680

aaacatggca aaggtagcgt tgccaatgat gttacagatg agatggtcag actaaactgg     4740

ctgacggaat ttatgcctct tccgaccatc aagcatttta tccgtactcc tgatgatgca     4800

tggttactca ccactgcgat ccccgggaaa acagcattcc aggtattaga agaatatcct     4860

gattcaggtg aaaatattgt tgatgcgctg gcagtgttcc tgcgccggtt gcattcgatt     4920

cctgtttgta attgtccttt taacagcgat cgcgtatttc gtctcgctca ggcgcaatca     4980

cgaatgaata acggtttggt tgatgcgagt gattttgatg acgagcgtaa tggctggcct     5040

gttgaacaag tctggaaaga aatgcataaa cttttgccat tctcaccgga ttcagtcgtc     5100

actcatggtg atttctcact tgataacctt atttttgacg aggggaaatt aataggttgt     5160

attgatgttg gacgagtcgg aatcgcagac cgataccagg atcttgccat cctatggaac     5220

tgcctcggtg agttttctcc ttcattacag aaacggcttt ttcaaaaata tggtattgat     5280

aatcctgata tgaataaatt gcagtttcat ttgatgctcg atgagttttt ctaagaatta     5340

attcatgagc ggatacatat ttgaatgtat ttagaaaaat aaacaaatag gggttccgcg     5400

cacatttccc cgaaaagtgc cacctgaaat tgtaaacgtt aatattttgt taaaattcgc     5460

gttaaatttt tgttaaatca gctcattttt taaccaatag gccgaaatcg gcaaaatccc     5520

ttataaatca aaagaataga ccgagatagg gttgagtgtt gttccagttt ggaacaagag     5580

tccactatta aagaacgtgg actccaacgt caaagggcga aaaaccgtct atcagggcga     5640

tggcccacta cgtgaaccat caccctaatc aagttttttg gggtcgaggt gccgtaaagc     5700

actaaatcgg aaccctaaag ggagcccccg atttagagct tgacggggaa agccggcgaa     5760

cgtggcgaga aaggaaggga agaaagcgaa aggagcgggc gctagggcgc tggcaagtgt     5820

agcggtcacg ctgcgcgtaa ccaccacacc cgccgcgctt aatgcgccgc tacagggcgc     5880

gtcccattcg cca                                                        5893



