                         SEQUENCE LISTING

<110>  SATOR Therapeutics LLC
 
<120>  OPTIMIZED ONCOLYTIC VIRUSES AND USES THEREOF

<130>  SATO 200002USP1

<160>  2     

<170>  PatentIn version 3.5

<210>  1
<211>  6630
<212>  DNA
<213>  Poliovirus Sabin strain Type 1

<400>  1
atgggtgctc aggtttcatc acagaaagtg ggcgcacatg aaaactcaaa tagagcgtat       60

ggtggttcta ccattaatta caccaccatt aattattata gagattcagc tagtaacgcg      120

gcttcgaaac aggacttctc tcaagaccct tccaagttca ccgagcccat caaggatgtc      180

ctgataaaaa catccccaat gctaaactcg ccaaacatag aggcttgcgg gtatagcgat      240

agagtactgc aattaacact gggaaactcc actataacca cacaggaggc ggctaattca      300

gtagtcgctt atgggcgttg gcctgaatat ctgagggaca gcgaagccaa tccagtggac      360

cagccgacag aaccagacgt cgctgcatgc aggttttata cgctagacac cgtgtcttgg      420

acgaaagagt cgcgagggtg gtggtggaag ttgcctgatg cactgcggga catgggactc      480

tttggccaaa atatgtacta ccactaccta ggtaggtccg ggtacaccgt gcatgtacag      540

tgtaacgcct ccaaattcca ccagggggca ctaggggtat tcgccgtacc agagatgtgt      600

ctggccgggg atagcaacac cactaccatg cacaccagct atcaaaatgc caatcctggc      660

gagaaaggag gcactttcac gggtacgttc actcctgacg acaaccagac atcacctgcc      720

cgtaggttct gcccggtgga ttacctcttt ggaaatggca cgttattggg gaatgccttt      780

gtgttcccgc accagataat aaacctacgg accaacaact gtgctacact ggtactccct      840

tacgtgaact ccctctcgat agatagtatg gtaaagcaca ataattgggg aattgcaata      900

ttaccattgg ccccattaaa ttttgctagt gagtcctccc cagagattcc aatcaccttg      960

accatagccc ctatgtgctg tgagttcaat ggattaagaa acattaccct gccacgctta     1020

cagggcctgc cggtcatgaa cacccctggt agcaatcaat atcttactgc agacaacttc     1080

cagtcaccgt gtgcgctgcc tgaatttgat gtgaccccac ctattgacat acccggtgaa     1140

gttaagaaca tgatggaatt ggcagaaatc gacaccatga ttccctttga cttaagtgca     1200

aaaaaaaaga acaccatgga aatgtatagg gttcggttaa gtgacaaacc acatacagac     1260

gatcccatac tctgcctgtc actctctcca gcttcagatc ctaggttgtc acatactatg     1320

cttggagaaa tcctaaatta ctacacacac tgggcaggat ccctgaagtt cacgtttctg     1380

ttctgtggat ccatgatggc aactggcaaa ctgttggtgt catacgcgcc tcctggagcc     1440

gacccaccaa agaagcgtaa ggaggcgatg ttgggaacac atgtgatctg ggacatagga     1500

ctgcagtcct catgtactat ggtagtgcca tggattagca acaccacgta tcggcaaacc     1560

atagatgata gtttcaccga aggcggatac atcagcgtct tctaccaaac cagaatagtc     1620

gtccctcttt cgacacccag agagatggac atccttggtt ttgtgtcagc gtgtaatgac     1680

ttcagcgtgc gcttgatgcg agataccaca catatagagc aaaaagcgct agcacagggg     1740

ttaggtcaga tgcttgaaag catgattgac aacacagtcc gtgaaacggt gggggcggca     1800

acgtctagag acgctctccc aaacactgaa gccagtggac cagcacactc caaggaaatt     1860

ccggcactca ccgcagtgga aactggggcc acaaatccac tagtcccttc tgatacagtg     1920

caaaccagac atgttgtaca acataggtca aggtcagagt ctagcataga gtctttcttc     1980

gcgcggggtg catgcgtggc cattataacc gtggataact cagcttccac caagaataag     2040

gataagctat ttacagtgtg gaagatcact tataaagata ctgtccagtt acggaggaaa     2100

ttggagttct tcacctattc tagatttgat atggaattta cctttgtggt tactgcaaat     2160

ttcactgaga ctaacaatgg gcatgcctta aatcaagtgt accaaattat gtacgtacca     2220

ccaggcgctc cagtgcccga gaaatgggac gactacacat ggcaaacctc atcaaatcca     2280

tcaatctttt acacctacgg aacagctcca gcccggatct cggtaccgta tgttggtatt     2340

tcgaacgcct attcacactt ttacgacggt ttttccaaag taccactgaa ggaccagtcg     2400

gcagcactag gtgactccct ctatggtgca gcatctctaa atgacttcgg tattttggct     2460

gttagagtag tcaatgatca caacccgacc aaggtcacct ccaaaatcag agtgtatcta     2520

aaacccaaac acatcagagt ctggtgcccg cgtccaccga gggcagtggc gtactacggc     2580

cctggagtgg attacaagga tggtacgctt acacccctct ccaccaagga tctgaccaca     2640

tatggattcg gacaccaaaa caaagcggtg tacactgcag gttacaaaat ttgcaactac     2700

catttggcca ctcaggaaga tttgcaaaac gcagtgaacg tcatgtggaa tagagacctc     2760

ttagtcacag aatcaagagc ccagggcacc gattcaatcg caaggtgcaa ttgcaacgca     2820

ggggtgtact actgcgagtc tagaaggaaa tactacccag tatccttcgt tggcccaacg     2880

ttccagtaca tggaggctaa taactattac ccagctaggt accagtccca tatgctcatt     2940

ggccatggat tcgcatctcc aggggattgt ggtggcatac tcagatgtca ccacggggtg     3000

atagggatca ttactgctgg tggagaaggg ttggttgcat ttacagacat tagagacttg     3060

tatgcctacg aagaagaagc catggaacaa ggcatcacca attacataga gtcacttggg     3120

gccgcatttg gaagtggatt tactcagcag attggagaca aaataacaga gttgactaat     3180

atggtgacca gtaccatcac tgaaaagcta cttaagaact tgatcaagat catatcctca     3240

ctagttatta taactaggaa ttatgaagac accacaacag tgctcgctac cctggccctt     3300

cttgggtgtg atgcttcacc atggcagtgg cttagaaaga aagcatgcga tgttctggag     3360

ataccttatg tcaccaagca aggtgacagt tggttgaaga agtttactga agcatgcaac     3420

gcagctaagg gactggagtg ggtgtcaaac aaaatctcaa aattcattga ttggctcaag     3480

gagaaaatta tcccacaagc tagagataag ttggaatttg taacaaaact tagacaacta     3540

gaaatgctgg aaaaccaaat ctcaactata caccaatcat gccctagtca ggaacaccag     3600

gaaattctat tcaataatgt cagatggtta tccatccagt ctaagaggtt tgcccctctt     3660

tacgcagtgg aagccaaaag aatacagaaa ctagagcata ccattaacaa ctacatacag     3720

ttcaagagca aacaccgtat tgaaccagta tgtttgctag tacatggcag ccccggaaca     3780

ggtaaatctg tagcaaccaa cctgattgct agagccatag ctgaaagaga aaacacgtcc     3840

acgtactcgc tacccccgga tccatcacac ttcgacggat acaaacaaca gggagtggtg     3900

attatggacg acctgaatca aaacccagat ggtgcggaca tgaagctgtt ctgtcagatg     3960

gtatcaacag tggagtttat accacccatg gcatccctgg aggagaaagg aatcctgttt     4020

acttcaaatt acgttctagc atccacgaac tcaagcagaa tttccccccc cactgtggca     4080

cacagtgatg cattagccag gcgctttgcg ttcgacatgg acattcaggt catgaatgag     4140

tattctagag atgggaaatt gaacatggcc atggctactg aaatgtgtaa gaactgtcac     4200

caaccagcaa actttaagag atgctgtcct ttagtgtgtg gtaaggcaat tcaattaatg     4260

gacaaatctt ccagagttag atacagtatt gaccagatca ctacaatgat tatcaatgag     4320

agaaacagaa gatccaacat tggcaattgt atggaggctt tgttccaagg accactccag     4380

tataaagact tgaagattga catcaagacg agtccccctc ctgaatgtat caatgacttg     4440

ctccaagcag ttgactccca ggaggtgaga gattactgtg agaagaaggg ttggatagtc     4500

aacatcacca gccaggttca aacagaaagg aacatcaaca gggcaatgac aattctacaa     4560

gcggtgacaa ccttcgccgc agtggctgga gttgtctatg tcatgtataa actgtttgct     4620

ggacaccagg gagcatacac tggtttacca aacaaaaaac ccaacgtgcc caccattagg     4680

acagcaaagg tacaagggcc agggttcgat tacgcagtgg ctatggctaa aagaaacatt     4740

gttacagcaa ctactagcaa gggagagttc actatgttag gagtccacga caacgtggct     4800

attttaccaa cccacgcttc acctggtgaa agcattgtga tcgatggcaa agaagtggag     4860

atcttggatg ccaaagcgct cgaagatcaa gcaggaacca atcttgaaat cactataatc     4920

actctaaaga gaaatgaaaa gttcagagac attagaccac atatacctac tcaaatcact     4980

gagacaaatg atggagtctt gatcgtgaac actagcaagt accccaatat gtatgttcct     5040

gtcggtgctg tgactgaaca gggatatcta aatctcggtg ggcgccaaac tgctcgtact     5100

ctaatgtaca actttccaac cagagcagga cagtgtggtg gagtcatcac atgtactggg     5160

aaagtcatcg ggatgcatgt tggtgggaac ggttcacacg ggtttgcagc ggccctgaag     5220

cgatcatact tcactcagag tcaaggtgaa atccagtgga tgagaccttc gaaggaagtg     5280

ggatatccaa tcataaatgc cccgtccaaa accaagcttg aacccagtgc tttccactat     5340

gtgtttgaag gggtgaagga accagcagtc ctcactaaaa acgatcccag gcttaagaca     5400

aactttgagg aggcaatttt ctccaagtac gtgggtaaca aaattactga agtggatgag     5460

cacatgaaag aggcagtaga ccactatgct ggccagctca tgtcactaga catcaacaca     5520

gaacaaatgt gcttggagga tgccatgtat ggcactgatg gtctagaagc acttgatttg     5580

tccaccagtg ctggctaccc ttatgtagca atgggaaaga agaagagaga tatcttgaac     5640

aaacaaacca gagacactaa ggaaatgcaa aaactgctcg acacatatgg aatcaacctc     5700

ccactggtga cttatgtaaa ggatgaactt agatccaaaa caaaggttga gcaggggaaa     5760

tccagattaa ttgaagcttc tagtttgaat gactcagtgg caatgagaat ggcttttggg     5820

aacctatatg ctgcttttca caaaaaccca ggagtgataa caggttcagc agtagggtgc     5880

gatccagatt tgttttggag caaaattccg gtattgatgg aagagaagct gtttgccttt     5940

gactacacag ggtatgatgc atctctcagc cctgcttggt tcgaggcact aaagatggtg     6000

cttgagaaaa tcggattcgg agacagagtt gactacatcg actacctaaa ccactcacac     6060

cacctgtaca agaataaaac atactgtgtc aagggcggta tgccatctgg ttgctcaggc     6120

acttcaattt ttaactcaat gattaacaac ttgattatca ggacactctt actgaaaacc     6180

tacaagggca tagatttaga ccacctaaaa atgattgcct atggtgatga tgtaattgct     6240

tcctaccccc atgaagttga cgctagtctc ctagcccaat caggaaaaga ctatggacta     6300

actatgactc cagctgacaa atcagctata tttgaaacag tcacatggga gaatgtaaca     6360

ttcttgaaga gattcttcag ggcagacgag aaatacccat ttcttattca tccagtaatg     6420

ccaatgaagg aaattcatga atcaattaga tggacaaaag atcctaggaa cactcaggat     6480

cacgttcgct ctctgtgcct attagcttgg cacaatggcg aagaagaata taacaaattc     6540

ctagctaaaa tcaggagtgt gccaattgga agagctttat tgctcccaga gtactcaaca     6600

ttgtaccgcc gttggcttga ctcattttag                                      6630


<210>  2
<211>  6630
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  optimized STR

<400>  2
atgggagctc aggtatcttc tcaaaaagtt ggggcccatg agaactctaa cagggcgtac       60

ggggggtcga ccataaacta caccaccata aattattata gggactctgc ctcgaacgcg      120

gcctcgaaac aagacttctc gcaagacccg tccaagttca ccgagccgat aaaggacgtc      180

ctcataaaaa ccgcacccat gctcaactcg cccaacatag aggcctgcgg gtactcggac      240

agggtcctcc aactaaccct cggtaactcc accataacca cccaagaggc ggccaactct      300

gtcgtcgcct acgggcgttg gccggagtac ctccgcgact cggaggcgaa ccccgttgac      360

caaccgaccg agcccgacgt cgccgcctgc cgcttctaca cgctcgacac cgtttcgtgg      420

acgaaagagt cgcgtgggtg gtggtggaag ttgccggacg ccctcaggga catgggttta      480

ttcgggcaaa acatgtacta ccactacctc gggcgctccg ggtacaccgt tcacgtccaa      540

tgcaacgcgt ccaaattcca ccaaggggcc ctcggagtct tcgcggtccc cgagatgtgc      600

ctcgcgggcg actcgaacac caccaccatg cacacctcgt accaaaacgc gaacccgggg      660

gagaaaggtg ggaccttcac ggggacgttc accccggaca ataaccaaac ctctccggcg      720

cgtcgcttct gcccggttga ctacttactt ggtaacggga cgctacttgg gaacgcgttc      780

gttttcccgc accaaataat aaacctccgt accaacaact gcgccaccct cgtcttaccg      840

tacgttaact ccttatcgat agactcgatg gtcaagcaca acaactgggg tatagccata      900

ctacccttgg cgcccctaaa cttcgcctcg gagtcctccc ccgagatacc cataaccttg      960

accatagcgc cgatgtgctg cgagttcaac ggtctaagga acattaccct cccccgtcta     1020

caagggctcc cggtcatgaa cacaccgggg tcgaaccaat acctaaccgc cgacaacttc     1080

caatctccgt gcgcgctccc ggagttcgac gttacccccc cgatagacat accgggggag     1140

gtcaagaaca tgatggagtt ggccgagata gacaccatga taccgttcga cctatcggcc     1200

accaaaaaga acaccatgga gatgtaccgc gtccgtctat cggacaaacc ccataccgac     1260

gacccgatat tatgcctctc tttatcgccc gcctctgacc cgcgcttgtc tcacaccatg     1320

ctaggtgaga tactcaacta ctacacccac tgggccggtt ccctcaagtt cacgttcctc     1380

ttctgtggtt ttatgatggc caccgggaaa ctcttggttt cttacgcgcc gccgggtgcg     1440

gaccccccca agaagcgtaa ggaggcgatg ttgggtaccc atgttatatg ggacataggt     1500

ctccaatcct cttgtaccat ggtcgttccc tggatatcga acaccacgta ccgtcaaacc     1560

atagacgact cgttcaccga ggggggttac atatcggtct tctaccaaac caggatagtc     1620

gtcccgctat cgaccccgag agagatggac atactagggt tcgtttctgc gtgcaacgac     1680

ttctcggttc gtttgatgcg tgacaccacc catatagagc aaaaagcgct cgcccaaggg     1740

ctagggcaaa tgctagagtc gatgatagac aacaccgtcc gtgagacggt tggggcggcc     1800

acctcgaggg acgccttacc caacaccgag gcgtcgggtc ccacccactc caaggagata     1860

ccggccttaa ccgccgttga gaccggggcg accaaccccc tcgtcccgtc ggacaccgtt     1920

caaaccaggc acgtcgtcca acaccgctct cgctctgagt cgtcgataga gtcgttcttc     1980

gcgcgtgggg cctgcgttac tataatgacc gttgacaacc ctgcctccac caccaacaag     2040

gacaagctct tcgccgtttg gaagataacc tacaaagaca ccgtccaact acgtcgcaaa     2100

ttggagttct tcacctactc gaggttcgac atggagttaa ccttcgttgt caccgccaac     2160

ttcaccgaga ccaacaacgg gcacgcgcta aaccaagttt accaaataat gtacgtcccc     2220

cccggggccc ccgttccgga gaaatgggac gactacacct ggcaaacctc ttctaacccc     2280

tctatattct acacctacgg taccgccccc gcgcgtatat cggtcccgta cgtcgggata     2340

tcgaacgcgt actctcactt ctacgacggg ttctccaaag tccccctcaa ggaccaatcg     2400

gccgccctcg gggactcctt atacggggcc gcctcgctca acgacttcgg gatattggcc     2460

gtcagggtcg tcaacgacca caacccgacc aaggtcacct ccaaaataag ggtttacctc     2520

aaaccgaaac acataagggt ctggtgcccg cgtccaccgc gcgccgttgc gtactacggg     2580

ccgggtgttg actacaagga cgggacgcta accccgttat ccaccaagga cctcaccacc     2640

tacggtttcg gtcaccaaaa caaagcggtt tacaccgccg ggtacaaaat atgcaactac     2700

catttggcga cccaagacga cttgcaaaac gccgttaacg tcatgtggtc gagggactta     2760

ctagtcaccg agtctagggc gcaagggacc gactctatag cccgctgcaa ctgcaacgcc     2820

ggggtttact actgcgagtc gaggcgcaaa tactaccccg tctccttcgt cgggcccacg     2880

ttccaataca tggaggccaa caactactac cccgcccgct accaatccca catgttaata     2940

gggcacggtt tcgcctcgcc cggggactgc ggggggatat taaggtgcca ccacggggtt     3000

atagggataa taaccgccgg gggagagggg ttggtcgcct tctccgacat aagggacttg     3060

tacgcgtacg aggaggaggc gatggagcaa gggataacca actacataga gtctctaggg     3120

gcggccttcg gttcgggttt cacccaacaa ataagtgaca aaataaccga gttgacaaac     3180

atggttacct cgaccataac cgagaagctc ctaaagaact tgataaagat aatatcctct     3240

ctcgtcataa taacccgcaa ttacgaggac accaccaccg ttttagccac cctcgcgcta     3300

ctagggtgcg acgcctctcc ctggcaatgg ctaaggaaga aagcctgcga cgtcctcgag     3360

ataccgtacg tcattaagca aggggactcg tggttgaaga agttcaccga ggcctgcaac     3420

gccgccaagg gtctcgagtg ggtttctaac aaaatatcta aattcataga ctggttaaag     3480

gagaaaataa taccccaagc cagggacaag ttggagttcg tcaccaaact aaggcaactc     3540

gagatgctcg agaaccaaat atctaccata caccaatctt gcccgtcgca agagcaccaa     3600

gagatactct tcaacaacgt caggtggcta tccatacaat cgaagcgctt cgcgccgcta     3660

tacgccgtgg aggcgaaaag gatacaaaaa ctcgagcata ctattaacaa ctacatacag     3720

ttcaagagca aacaccgtat tgaaccagta tgtttgctag tacacgggtc gccgggtacc     3780

ggtaaatcgg tcgccaccaa cctcatagcc agggcgatag ccgagaggga gaacacgtcc     3840

acgtactcgc tcccgccgga cccctctcac ttcgacggtt acaaacaaca aggtgttgtt     3900

ataatggacg acctcaacca aaaccccgac ggggcggaca tgaagctctt ctgtcaaatg     3960

gtctctaccg ttgagttcat acccccgatg gcctccctcg aggagaaagg tatactcttc     4020

acctctaact acgtcctcgc ctccaccaac tcttcgagga tatccccgcc gaccgttgcc     4080

cactcggacg ccctagcgcg ccgtttcgcg ttcgacatgg acatacaagt catgaacgag     4140

tactcgaggg acgggaaatt gaacatggcg atggccaccg agatgtgtaa gaactgtcac     4200

caacccgcca acttcaagag gtgctgcccg ctagtttgcg ggaaggccat acaactaatg     4260

gacaaatcgt ccagggtcag gtactcgata gaccaaataa ccaccatgat aataaacgag     4320

aggaacagga ggtccaacat agggaactgt atggaggcct tgttccaagg tcccttacaa     4380

tacaaagact tgaagataga cataaagacg tcgccgccgc cggagtgcat aaacgacttg     4440

ttacaagccg tcgactccca agaggttagg gactactgtg agaagaaggg gtggatagtc     4500

aacataacct cgcaagtcca aaccgagcgc aacataaacc gcgccatgac catactccaa     4560

gcggttacca ccttcgcggc cgttgccggt gtcgtctacg tcatgtacaa actcttcgcc     4620

ggtcaccaag gtgcctacac cgggctaccc aacaaaaaac cgaacgttcc gaccataaga     4680

accgccaagg tccaagggcc cgggttcgac tacgccgttg ccatggccaa aaggaacata     4740

gtcaccgcca ccacctcgaa gggtgagttc accatgctag gtgtccacga caacgttgcc     4800

atactaccca cccacgcctc tccgggggag tcgatagtta tagacgggaa agaggttgag     4860

atattggacg cgaaagcgtt agaggaccaa gccggtacca acctagagat aaccataata     4920

accctcaaga ggaacgagaa gttcagggac ataaggcccc acataccgac ccaaataacc     4980

gagaccaacg acggagtctt gatcgtgaac actagcaagt accccaatat gtatgttcct     5040

gtcggtgctg tgactgaaca gggatatcta aatctcggtg ggcgccaaac cgcccgtacc     5100

ctcatgtaca acttccccac cagggccggt caatgcgggg gtgtcataac ctgcaccggg     5160

aaagtcatcg ggatgcatgt tggtgggaac ggttcacacg ggtttgcagc ggccctgaag     5220

cgatcatact tcacccaatc gcaaggggag atacaatgga tgaggccgtc gaaggaggtt     5280

ggttacccca taataaacgc gccgtccaaa accaagctag agccgtcggc cttccactac     5340

gttttcgagg gggttaagga gcccgccgtc ttaaccaaaa acgacccgcg cctaaagacc     5400

gatttcgagg aggccatatt ctccaagtac gttgggaaca aaataaccga ggttgacgag     5460

tatatgaaag aggccgtcga ccactacgcc gggcaattaa tgtctctcga cataaacacc     5520

gagcaaatgt gcttggagga cgcgatgtac gggaccgacg ggctcgaggc cctagacttg     5580

tccacctcgg ccgggtatcc gtacgtcgcc atgggtaaga agaagaggga tatattgaac     5640

aaacaaacca gggacaccaa ggagatgcaa aaactcttag acacctacgg tataaactta     5700

cccctcgtta cctacgtcaa ggacgagcta aggtccaaaa ccaaggtcga gcaagggaaa     5760

tccaggctaa tagaggcctc gtcgttgaac gactctgttg ccatgaggat ggccttcggg     5820

aacctctacg ccgccttcca caaaaacccc ggtgttataa ccgggtctgc cgtggggtgc     5880

gaccccgact tgttctggtc gaaaataccg gtcttgatgg aggagaagct cttcgccttc     5940

gactacaccg ggtacgacgc ctcgttatcg ccggcctggt tcgaggccct caagatggtt     6000

ctagagaaaa taggtttcgg tgacagggtc gactacatag actacctcaa ccactctcac     6060

cacctctaca agaacaaaac ctactgcgtc aaggggggga tgccctcggg atgctctggg     6120

acctctatat tcaactctat gataaacaac ttgataatac gcaccttact actcaaaacc     6180

tacaagggga tagacctaga ccacctcaaa atgatagcgt acggggacga cgtcatagcc     6240

tcctaccccc atgaagttga cgctagtctc ctagcccaat caggaaaaga ctatggacta     6300

actatgactc cagctgacaa atcagctaca tttgagaccg tcacctggga gaacgtcacc     6360

ttcttgaaga ggttcttccg cgccgacgag aaatacccct tcctaataca ccccgtcatg     6420

cccatgaagg agatacacga gtctataagg tggaccaaag acccgcgcaa cactcaggat     6480

cacgttcgct ctctgtgcct tttagcttgg cacaatggcg aagaagaata taacaaattc     6540

ctagctaaaa tcaggagtgt gccaattgga agagctttat tgctcccaga gtactcaaca     6600

ttgtaccgcc gttggcttga ctcattttag                                      6630


