                         SEQUENCE LISTING

<110> Cero Therapeutics, Inc.
      Corey, Daniel Mark

<120> CHIMERIC ENGULFMENT RECEPTOR MOLECULES
  

<130> 200265.401WO

<140> PCT                 
<141> 2017-09-26  

<150> US 62/445,235       
<151> 2017-01-11  

<150> US 62/400,578       
<151> 2016-09-27  

<160> 153

<170> FastSEQ for Windows Version 4.0

<210>  1
<211>  870
<212>  DNA
<213>  Homo sapiens

<220>
<223> Tim1 binding domain

<400>  1
atgcaccccc aggttgttat actttcattg atcctgcatt tggccgactc cgtggcgggt       60

tccgtaaaag ttggagggga agctggacca agcgtcacct tgccttgcca ctactctgga      120

gccgtgacga gtatgtgctg gaatcgagga tcctgtagtc ttttcacatg ccaaaatggc      180

atagtttgga ccaatgggac gcacgtcacc taccgaaaag acactagata caaactcctg      240

ggtgacctca gcaggagaga tgtgtctctg actattgaaa acactgctgt ttctgactct      300

ggagtctact gttgccgggt cgagcaccga ggatggttca atgacatgaa gatcacggtc      360

agcttggaaa tcgtcccgcc caaggtaacc actacaccaa tagttactac ggttcccacg      420

gtaaccacgg ttcgaaccag caccacagta cccacaacta cgaccgttcc aaccactaca      480

gtccccacaa ccatgagtat ccctacgaca actacggtcc tgacaaccat gaccgtcagc      540

actaccacga gtgtgcctac gactactagc ataccgacga ctacttcagt tccagtcacc      600

accacggtga gtacattcgt gcctccaatg ccattgccga ggcaaaacca cgaacccgtg      660

gcgacatctc cgtctagtcc gcaaccagca gagacccatc ccaccacgct tcagggggca      720

atcaggagag aacctacaag ttcacccctc tacagctata caaccgatgg aaacgacaca      780

gttacagaaa gtagtgacgg tttgtggaat aacaaccaaa cacaattgtt cctggagcac      840

agtctgttga cagccaacac tacaaaggga                                       870


<210>  2
<211>  942
<212>  DNA
<213>  Homo sapiens

<220>
<223> Tim4 binding domain

<400>  2
atgagtaaag agccgcttat cctgtggctt atgatagagt tttggtggtt gtatttgacc       60

ccggtcacga gcgaaacggt agtgactgaa gtattgggtc atcgggtaac cttgccttgc      120

ttgtatagct cctggtctca taatagtaat agcatgtgct ggggcaagga ccaatgcccc      180

tatagcggat gcaaggaggc gctcattcgc acagacggaa tgcgggtgac atcaaggaag      240

agtgctaagt accggcttca gggcacaatc ccacgcggcg acgtgtcact gactatcctt      300

aatccatccg agagcgactc tggtgtctat tgttgcagga tcgaggttcc gggatggttc      360

aatgatgtaa agatcaatgt aagactcaat ctgcaacggg catctacaac cacgcatcgg      420

acagccacta ctaccacaag gagaacaact actacgtcac ccacgactac tcgacagatg      480

accactacac ctgcggccct gccaactacg gttgtaacta ctccggatct gacaaccggg      540

acaccgttgc aaatgacaac cattgcagta tttaccacgg caaacacgtg tctctctctg      600

accccatcta ctcttccgga ggaggccacc gggctcctta caccggagcc gtctaaggaa      660

ggcccaatct tgaccgcaga gagtgagacc gtacttccga gcgattcatg gtccagtgtc      720

gagagcacat ccgctgacac cgtccttctt acgtccaaag aaagtaaagt ttgggacctc      780

ccgtccacga gccacgtttc tatgtggaag acctcagata gcgttagctc cccacagcca      840

ggagcaagcg acaccgcagt accggagcaa aacaagacga ctaagactgg ccagatggat      900

ggtatcccaa tgtcaatgaa aaatgagatg cccatatcac aa                         942


<210>  3
<211>  483
<212>  DNA
<213>  Homo sapiens

<220>
<223>  FA58C2 binding domain

<400>  3
ctcaacgggt gtgctaatcc ccttggcctg aagaataaca gcatacctga caagcaaata       60

acagcgtcaa gttcttataa aacttggggg ctgcatctgt tctcctggaa ccccagttac      120

gctagactcg acaaacaagg caattttaac gcatgggtgg caggctctta cgggaacgat      180

cagtggctgc aagtagactt gggaagtagt aaggaggtga ctgggatcat tacccagggg      240

gcacgaaatt tcggttccgt tcagttcgtt gcatcttata aggtagcgta ttcaaatgac      300

tccgcgaatt ggaccgaata tcaggacccg cgaaccggat caagcaagat ttttccgggg      360

aattgggaca accactctca caaaaaaaat ttgtttgaaa cacctatact ggcgcggtac      420

gttagaatcc tcccagttgc ctggcacaac cggatagcgc ttagactgga attgttgggg      480

tgc                                                                    483


<210>  4
<211>  876
<212>  DNA
<213>  Homo sapiens

<220>
<223> FcgammaRI binding domain

<400>  4
atgtggttcc tgactacgtt gttgctgtgg gtccctgtag acggccaagt agacacaacg       60

aaagcagtga tcacgctcca accgccttgg gtgtctgtgt tccaagaaga aacagttaca      120

ctgcactgtg aggtcctcca cctgcctggt tcttcatcta ctcaatggtt tctcaacgga      180

acagcaacac aaacaagtac cccttcctac agaattacga gtgcatctgt taacgattca      240

ggagagtata ggtgccagcg agggctttca ggccggtccg accccattca actcgaaatt      300

caccgcggtt ggcttctgct gcaagtatcc tctcgggtct tcacggaagg tgaaccactt      360

gccttgcgct gtcacgcatg gaaagataag ctcgtctaca acgttttgta ttatcggaat      420

ggaaaggcat ttaagttttt tcattggaac tcaaacctta cgatcctcaa aaccaatatc      480

agtcataacg gtacgtacca ctgctcaggc atgggcaagc atcgctatac gtccgcaggg      540

attagcgtga cagttaagga gctcttcccc gcgcctgtgc tgaatgcgag cgtaacttca      600

ccccttctgg agggcaactt ggtgaccctc tcttgtgaga cgaaacttct ccttcagagg      660

ccgggcctgc aactctattt cagcttttat atgggttcta aaactcttcg aggcagaaac      720

acgagcagcg aatatcagat actgactgcc cggcgggaag acagtggcct ttattggtgc      780

gaggctgcaa cagaagatgg caatgtcctt aaaaggtctc ccgaattgga gctccaagtg      840

cttggcttgc aactccctac acccgtatgg ttccac                                876


<210>  5
<211>  282
<212>  DNA
<213>  Homo sapiens

<220>
<223>  GAS6 binding domain

<400>  5
atggctccct ctttgtcacc aggacctgcg gctcttaggc gagccccgca gctgctgctt       60

ctcctgctcg ctgcagaatg cgctctcgct gcactcttgc ccgcgaggga ggcgactcag      120

ttcttgcgcc cccggcagag acgagcattc caagtctttg aggaagcgaa acaaggtcat      180

ctcgagcgag aatgcgtgga ggagctgtgt tctagggagg aagcacgcga agtctttgag      240

aatgacccgg aaacggacta cttttacccc cggtatcttg at                         282


<210>  6
<211>  261
<212>  DNA
<213>  Homo sapiens

<220>
<223> Protein S binding domain

<400>  6
atgcgcgtgt tggggggtcg ctgtggtgcg ctccttgctt gtctcctttt ggttcttccc       60

gtctccgagg ctaatttcct gtcaaaacaa caggctagtc aagtcttggt gcgcaagagg      120

agagctaaca gccttctgga agagaccaag caaggtaatc tggagagaga gtgtatcgag      180

gaactttgta acaaagagga agcacgcgaa gtatttgaaa atgacccgga aaccgattat      240

ttttacccaa aatatctcgt a                                                261


<210>  7
<211>  606
<212>  DNA
<213>  Homo sapiens

<220>
<223>  Tim3 binding domain

<400>  7
atgtttagcc atctcccttt tgattgcgtc ttgttgcttc ttcttctcct tctgacgaga       60

tcatctgaag ttgaatatcg cgcggaagtc ggccaaaacg catatctgcc gtgtttttac      120

accccggctg caccggggaa cttggttccc gtttgttggg gtaagggggc gtgtcccgtt      180

tttgagtgcg gtaacgtagt gctccgaact gatgaaagag atgtaaatta ctggacgagc      240

cggtactggt tgaatgggga ttttaggaag ggcgacgttt cccttaccat agaaaacgta      300

actcttgcgg attctgggat ttattgttgc aggatacaaa tccccggaat aatgaacgat      360

gagaaattca atttgaagct cgtaataaaa ccggcaaaag taactccagc tcccaccagg      420

cagcgagatt ttacggcagc atttcccagg atgctcacta ctcgcggtca tggccctgcc      480

gagactcaga ccctcggtag tcttcctgat atcaatctca cgcaaattag tacattggcg      540

aatgaattga gggattcaag actcgccaat gatctgcgcg acagtggagc gactattagg      600

ataggg                                                                 606


<210>  8
<211>  63
<212>  DNA
<213>  Homo sapiens

<220>
<223> Tim1 transmembrane domain

<400>  8
atatacgctg gagtctgtat aagtgtcctt gtactgttgg cgttgctggg ggtcattatt       60

gcc                                                                     63


<210>  9
<211>  63
<212>  DNA
<213>  Homo sapiens

<220>
<223>  Tim4 transmembrane domain

<400>  9
ttgcttatga ttattgcgcc aagccttgga tttgtgctgt tcgcactctt cgtagctttt       60

ctc                                                                     63


<210>  10
<211>  63
<212>  DNA
<213>  Homo sapiens

<220>
<223> FcgammaRI transmembrane domain

<400>  10
gtactgtttt atctcgccgt agggataatg ttcctcgtga acaccgtact gtgggtaaca       60

ata                                                                     63


<210>  11
<211>  63
<212>  DNA
<213>  Homo sapiens

<220>
<223> CD8a transmembrane domain

<400>  11
atatacattt gggcaccgct ggctggaact tgcggcgttc tcttgttgag tctggtgatt       60

act                                                                     63


<210>  12
<211>  63
<212>  DNA
<213>  Homo sapiens

<220>
<223>  MERTK transmembrane domain

<400>  12
tttggctgtt tctgtggatt tattctgatt ggtcttatcc tctatatttc cttggcgatc       60

aga                                                                     63


<210>  13
<211>  63
<212>  DNA
<213>  Homo sapiens

<220>
<223>  Axl transmembrane domain

<400>  13
tatgtcttgc ttggtgccgt cgttgctgcc gcctgtgtgt tgatactcgc acttttcttg       60

gtg                                                                     63


<210>  14
<211>  63
<212>  DNA
<213>  Homo sapiens

<220>
<223> Tyro3 transmembrane domain

<400>  14
gtacccgtcg ttttgggggt cctgaccgcg ctcgttactg cggcagcact cgcactgata       60

ctt                                                                     63


<210>  15
<211>  66
<212>  DNA
<213>  Homo sapiens

<220>
<223>  CD4 transmembrane domain

<400>  15
atggctctga tcgtactggg cggagtggca ggattgctgc tctttattgg actgggcatt       60

ttcttc                                                                  66


<210>  16
<211>  1428
<212>  DNA
<213>  Mus musculus

<220>
<223> MERTK signaling domain

<400>  16
gcgctgcggc gaagggtaca ggagacgaaa ttcgggggag cctttagtga agaagacagc       60

cagttggtgg taaattacag agcgaaaaaa tctttctgcc gacgcgctat tgagcttact      120

cttcaaagcc tcggtgtaag tgaggagttg cagaataaat tggaggacgt agtcatcgac      180

cgcaaccttc tggtcctcgg aaaagtcctc ggagaaggtg aattcggctc agtaatggaa      240

ggcaatctca aacaagaaga cggaacttct cagaaggtag cagtaaaaac catgaaactc      300

gacaacttca gccagcggga aatcgaagaa ttcctgtccg aagccgcctg tatgaaagac      360

ttcaatcacc caaacgtgat aagacttctc ggcgtatgta tagagttgtc ttcccagggc      420

atccccaaac caatggtgat actcccattt atgaagtacg gggacttgca cacattcctg      480

ttgtattcca gacttaatac aggacccaag tatatacatt tgcagaccct gctcaaattt      540

atgatggaca tcgcgcaggg gatggagtat ctcagcaaca ggaatttttt gcatcgcgac      600

cttgctgcca ggaactgtat gttgagggac gacatgacgg tgtgtgtagc cgacttcggt      660

cttagcaaga agatctattc tggagactat tacaggcaag gcagaatagc taagatgccg      720

gtcaagtgga tcgctattga gagcctcgca gaccgggtct atacttcaaa gtcagacgtt      780

tgggcttttg gggtaaccat gtgggagatc actacgaggg ggatgacgcc ctatcccggg      840

gtccaaaatc acgagatgta tgattatctc ttgcatggcc accggctgaa acagcctgag      900

gactgtctgg acgagctcta cgatattatg tattcttgtt ggtccgcgga ccccctcgat      960

agaccaacct tttctgttct tcgactgcag ctcgaaaagc tttccgaatc tttgcctgat     1020

gcacaggaca aagaaagcat catttatata aatacacagc tcctggaatc ttgcgaagga     1080

attgctaatg gacctagtct gactggattg gacatgaata ttgacccgga cagcataatt     1140

gcatcttgca cacctggtgc agcggtatca gtcgtgacgg ccgaggtcca tgaaaacaat     1200

ctgcgggagg agcggtacat tttgaacggc ggaaacgaag agtgggagga cgtcagctca     1260

accccctttg cagccgtgac gccagagaaa gacggggtac ttcctgagga ccgccttacc     1320

aagaacgggg tatcctggtc tcaccacagc accctcccac ttgggagtcc atctcccgac     1380

gagcttctct tcgtagatga ttcacttgaa gattcagagg tgctcatg                  1428


<210>  17
<211>  1266
<212>  DNA
<213>  Homo sapiens

<220>
<223> Axl signaling domain

<400>  17
caccggagaa aaaaagagac ccgctacgga gaggtctttg agcctacggt cgagagaggt       60

gagcttgttg tccggtacag agtgaggaag agctattcac ggaggactac tgaagccacc      120

ctgaattcac tcggcatcag cgaagagctg aaagagaaac ttcgggacgt aatggtcgat      180

cggcacaagg tagccctcgg gaagacgttg ggagagggcg aatttggggc cgtcatggag      240

ggtcagttga accaagatga ctcaatactt aaagtagcag tcaaaacgat gaaaatcgca      300

atttgtactc gctcagagct cgaagacttt ctctctgagg cggtatgcat gaaggaattc      360

gaccacccaa atgtaatgcg attgatcggt gtctgcttcc aaggttccga aagagagtca      420

tttcctgcac ccgttgtcat tttgccattt atgaagcatg gggacctcca ctcatttctc      480

ctctattcta gattgggtga ccaaccggtt tacctcccga cccaaatgct cgttaagttc      540

atggccgaca ttgcttccgg gatggagtac ctgagtacca agcggtttat acatcgggat      600

ctcgcagcac gaaactgcat gttgaatgag aacatgtctg tctgtgtggc tgactttgga      660

ctctccaaaa aaatttacaa cggtgattat taccgccagg gaagaatcgc taagatgccc      720

gtgaagtgga tagctattga gtcactcgct gatcgcgtat acactagtaa gtccgacgta      780

tggtcctttg gtgtcacaat gtgggagatt gcgaccaggg ggcagacacc atatcccggc      840

gtggagaact ccgagattta tgattatctg cgacagggta acagacttaa gcaacctgcc      900

gattgcttgg atgggctcta cgctctgatg tctagatgct gggaattgaa tcctcaagat      960

cggccaagct tcactgaact gagagaagac ctggaaaata ccctgaaagc gctcccgccg     1020

gcgcaagaac cagatgaaat cttgtacgtc aatatggacg aagggggagg ctaccctgaa     1080

ccccctgggg cggccggtgg ggcggacccc ccgacacaac cagatccgaa agactcctgt     1140

tcttgtctta ccgctgctga ggtacatccg gcaggaagat atgttttgtg tccctctacg     1200

acaccctctc ccgcacagcc cgcggatcgc gggtcacccg cggctccagg acaagaagat     1260

ggggca                                                                1266


<210>  18
<211>  1320
<212>  DNA
<213>  Homo sapiens

<220>
<223>  Tyro3 signaling domain

<400>  18
ttgcggaagc ggcgaaagga aaccagattc ggtcaagctt tcgacagcgt aatggcccgg       60

ggtgagccag ccgtccactt tagagccgct cggagcttca atagggaacg accggagaga      120

atcgaggcta ctctcgattc tctcggaata tctgacgagt tgaaagaaaa actggaggat      180

gtcctcatcc cagaacaaca atttaccctc ggccgaatgc ttggaaaggg tgagtttggg      240

tcagttcgcg aggcgcagct taaacaggaa gacggtagtt ttgttaaagt cgcagtaaaa      300

atgttgaagg cggacataat cgcatccagc gatattgagg aatttcttcg cgaagcggca      360

tgtatgaaag agttcgacca cccgcacgtt gccaagctcg tgggcgtgtc tcttcgaagc      420

cgagctaagg gtagactccc tatcccaatg gtaatacttc cttttatgaa acatggggac      480

ttgcacgctt ttctgctcgc ttccaggata ggagaaaatc cgtttaattt gccgctccaa      540

acgcttatca ggtttatggt tgatattgcg tgtgggatgg aatacttgag ttcacgcaat      600

ttcatccatc gagacctggc cgcgcgaaat tgtatgctcg cagaggatat gaccgtatgt      660

gtagctgatt tcggcttgtc acgcaagata tatagcggcg attattatag acagggttgt      720

gcctctaagc tccctgtaaa gtggttggca ttggaatcac tggcggataa cctctatact      780

gtccagtcag atgtgtgggc atttggtgtc actatgtggg agattatgac acggggtcag      840

acaccctacg caggaatcga gaacgcggag atatataact acctgatagg tggcaaccga      900

ctgaaacaac ctccggaatg catggaggac gtgtatgacc tcatgtacca gtgttggagt      960

gccgatccga aacaaagacc tagtttcact tgcctgagaa tggagttgga gaatattttg     1020

ggtcagttgt ccgtactgag cgccagccaa gatccgttgt atataaatat agagcgggcg     1080

gaggagccca cggccggcgg gtccctggaa cttcctggac gagaccaacc gtactcaggg     1140

gccggagatg gaagtggaat gggggctgtt gggggcacac cgtccgactg ccgatacata     1200

ctcactccgg gcggtctcgc agaacaaccg ggtcaagcag aacatcaacc agaaagtcca     1260

ctcaatgaga cacagcgact gttgttgttg caacagggct tgctgcctca ctcatcctgt     1320


<210>  19
<211>  783
<212>  DNA
<213>  Homo sapiens

<220>
<223> Syk signaling domain

<400>  19
acattggaag acaaagaact ggggtctggg aacttcggga cagtcaaaaa ggggtactac       60

cagatgaaaa aagttgtcaa aactgtggcg gtaaaaatct tgaaaaatga agctaatgac      120

cctgcactca aggatgagct tctggcagaa gctaacgtga tgcagcagct tgataatcct      180

tatattgttc gcatgatagg tatatgtgag gcggaaagct ggatgctcgt aatggaaatg      240

gcagaactgg gaccattgaa taaatatctg caacaaaata gacatgtgaa ggataaaaac      300

atcatagagc tcgtacacca agtctctatg gggatgaagt acttggagga gagcaacttc      360

gtgcataggg acttggccgc ccgaaacgta ctgctcgtaa ctcaacatta cgcgaaaatc      420

tcagacttcg gtttgtctaa agcactccgg gcagacgaga actactacaa agcccaaact      480

cacggcaagt ggccagtcaa gtggtacgcg ccggaatgca taaactatta caagtttagt      540

tctaagtctg atgtgtggag cttcggggtt ctgatgtggg aagcctttag ttatggacag      600

aagccctacc gggggatgaa aggaagcgag gtaacagcta tgctggaaaa aggggagcgg      660

atgggctgtc cagcggggtg tcctcgagaa atgtatgatc tcatgaacct gtgttggacc      720

tacgatgtcg agaatcgccc gggctttgct gcggtggaac ttagactgag gaattattac      780

tac                                                                    783


<210>  20
<211>  789
<212>  DNA
<213>  Homo sapiens

<220>
<223>  Zap70 signaling domain

<400>  20
ctcattgccg acatcgaact tggttgcggc aacttcggat ctgtgagaca aggcgtctac       60

cggatgagaa agaagcagat tgacgttgca atcaaagtcc tgaagcaggg cacggaaaag      120

gcggacaccg aggagatgat gcgcgaggct cagattatgc accagctcga caatccgtac      180

atcgttagac ttatcggagt ttgccaggca gaagcgttga tgctcgtgat ggagatggca      240

ggcggtggtc ctctgcataa atttttggta ggcaagcgag aagagatccc cgtcagcaat      300

gtagcagaat tgttgcatca agtgagcatg gggatgaagt accttgagga aaaaaatttc      360

gtacatcgcg acctcgctgc gagaaatgtg cttttggtaa atcgccatta cgctaaaatt      420

agtgactttg gactcagtaa ggcattgggt gctgacgact catattacac ggcaagaagc      480

gcaggtaagt ggcctctgaa gtggtatgct cccgagtgca tcaacttccg caagttttct      540

tccaggtctg acgtttggag ctacggtgtc acgatgtggg aagccctgag ctatggtcag      600

aaaccttaca agaaaatgaa gggacctgaa gtcatggcct ttatagagca gggaaagaga      660

atggagtgtc ccccagaatg cccacccgag ctctatgcac tgatgagtga ctgctggatt      720

tacaaatggg aggatcggcc tgactttctt acggttgagc aaaggatgag ggcgtgctat      780

tattctctg                                                              789


<210>  21
<211>  183
<212>  DNA
<213>  Homo sapiens

<220>
<223>  FcgammaRI signaling domain

<400>  21
agaaaggaac tcaagcgcaa gaagaagtgg gacctggaga tttctctcga ctccggtcac       60

gaaaagaagg tcatcagtag cttgcaagag gaccgacact tggaagaaga acttaaatgc      120

caggaacaga aagaggagca gctccaggag ggagtccacc ggaaagaacc acagggagca      180

act                                                                    183


<210>  22
<211>  231
<212>  DNA
<213>  Homo sapiens

<220>
<223>  FcgammaR2A signaling domain

<400>  22
tgtcgaaaga agcggatttc agccaatagt acagacccag tgaaagccgc tcaatttgag       60

ccacccggtc gacagatgat cgcaattagg aaacgccaac tggaggaaac gaataatgat      120

tacgaaacgg cagatggggg ctacatgacg ctcaatccta gagctccgac cgacgacgac      180

aagaatatat atctgactct ccctcccaac gaccacgtaa acagtaataa c               231


<210>  23
<211>  231
<212>  DNA
<213>  Homo sapiens

<220>
<223>  FcgammaR2C signaling domain

<400>  23
tgcagaaaga agcggataag tgcaaatagt actgatcccg ttaaagcagc acaatttgag       60

ccgccaggac ggcaaatgat tgcaatcaga aaacgacaac ccgaggaaac caataatgac      120

tacgagaccg ctgacggagg gtatatgacg ttgaatcccc gcgcaccaac ggatgacgat      180

aagaacattt atcttacgct gccccctaac gatcatgtga atagcaataa c               231


<210>  24
<211>  75
<212>  DNA
<213>  Homo sapiens

<220>
<223>  FcgammaR3A signaling domain

<400>  24
aaaacaaata tccggtcctc tacgagggac tggaaagatc ataaattcaa gtggagaaaa       60

gatcctcagg ataaa                                                        75


<210>  25
<211>  168
<212>  DNA
<213>  Mus musculus

<220>
<223> ItgB5 signaling domain

<400>  25
aagttgcttg taacaataca cgaccgccgg gagttcgcta agttccaatc agaaaggtct       60

agagcgcggt atgaaatggc atctaacccc ttgtaccgga aacctatctc tacgcacacg      120

gtggatttcg catttaataa gttcaataag agttacaacg gctcagtc                   168


<210>  26
<211>  888
<212>  DNA
<213>  Homo sapiens

<220>
<223>  MyD88 signaling domain

<400>  26
atggccgcgg gtggacccgg tgcagggtct gccgcaccgg tgtctagcac cagctcactg       60

ccgctggcag cgttgaacat gagggtaaga agacggctta gtcttttctt gaatgtgcga      120

acgcaggtgg ccgctgactg gacggccctc gctgaggaaa tggacttcga gtacctggag      180

atccggcaac tcgagactca agccgaccct actggaagat tgctcgatgc ctggcaggga      240

aggcccggcg catcagttgg taggttgttg gaactcctca ccaaactcgg gcgagatgat      300

gttcttttgg aacttggccc tagtattgag gaggactgtc aaaaatatat tctgaaacaa      360

caacaggaag aagcggagaa accgttgcaa gtggccgcag tcgattcttc agtgccgcgc      420

acagccgaac tggctggaat tactaccctg gatgatcccc tcggacacat gccggagcgg      480

ttcgacgcct tcatttgcta ttgtccctcc gacatccagt ttgtgcagga aatgattagg      540

caactcgaac aaaccaacta taggcttaaa ctgtgtgtgt ccgatcgaga tgttttgcct      600

ggtacttgcg tatggtctat tgccagcgaa ctcatagaga aacgctgtcg ccgcatggta      660

gtggtcgtat ccgacgacta ccttcagtcc aaagagtgtg acttccagac gaaatttgca      720

ctgtcactga gtcctggagc acaccaaaaa aggctgattc cgatcaagta taaggcgatg      780

aagaaggaat ttccttccat cctgaggttc ataactgtat gcgattacac aaatccgtgt      840

actaaatcct ggttctggac tcgacttgcc aaggcactgt ccctccca                   888


<210>  27
<211>  1566
<212>  DNA
<213>  Homo sapiens

<220>
<223>  Traf6 signaling domain

<400>  27
atgtcactcc ttaactgcga aaacagttgt gggagttcac aatccgaaag tgattgttgc       60

gtggcgatgg cgtcttcatg ctctgcggtt accaaggatg actctgtggg aggcaccgca      120

tctaccggaa atctgagctc ttcttttatg gaggaaattc agggctacga cgttgagttt      180

gatcctcctc tcgaatctaa gtatgagtgc cccatatgtc tcatggcgtt gagagaagca      240

gtgcagactc cgtgcggaca tcgcttctgc aaggcgtgta ttataaagag tatacgcgat      300

gcgggtcaca aatgtccagt ggacaacgag atactgcttg aaaatcaact tttccccgac      360

aattttgcaa agagagagat actgtctttg atggttaagt gtccaaacga gggctgcttg      420

cacaaaatgg aactccgaca ccttgaagac caccaggcac actgcgagtt cgccctcatg      480

gattgcccac aatgccagcg cccgttccaa aagtttcaca taaacatcca catactgaag      540

gactgtccta ggagacaagt aagctgtgac aattgcgcag cgtcaatggc gttcgaggac      600

aaggagatac acgatcaaaa ctgtcctctg gcgaatgtga tctgcgaata ttgcaatacg      660

atcttgatcc gcgaacagat gcctaatcat tacgacctcg attgtccgac cgcgccaatt      720

ccttgtactt tttctacctt cggatgtcat gagaaaatgc aacgaaatca cctggctcgc      780

catcttcagg agaatactca gagccacatg cgcatgttgg ctcaagccgt acatagcctt      840

agcgtaatac cggactcagg ttatatatcc gaagtacgga attttcaaga aaccatacat      900

caacttgaag gaaggttggt acgacaggat catcagatac gcgaattgac ggccaagatg      960

gaaacccaga gcatgtatgt cagtgagctt aagcgcacta tccgaaccct ggaggataaa     1020

gttgccgaaa tcgaagctca acaatgcaac gggatataca tttggaaaat aggtaacttc     1080

ggaatgcacc tgaagtgtca agaagaagaa aaacctgtcg ttattcattc ccccggcttt     1140

tatacaggga agcctgggta taagctttgc atgaggctcc acctccaatt gccgacggcg     1200

caaaggtgcg caaattacat ttctctgttt gtccatacta tgcagggtga gtacgatagt     1260

cacttgccgt ggcccttcca gggtaccata cgattgacca tcctggatca gagcgaggcc     1320

cccgtgcgac agaatcatga agaaataatg gatgctaagc cggaactgct cgctttccag     1380

agacctacaa ttccgcgaaa tcctaagggt tttggctatg ttacgttcat gcatctggaa     1440

gcactcagac aaagaacatt cattaaagat gacaccttgc ttgtgcggtg tgaggtgtca     1500

accaggttcg acatgggatc tctcagacgg gaggggttcc aaccgcgctc tacagacgct     1560

ggagtg                                                                1566


<210>  28
<211>  290
<212>  PRT
<213>  Homo sapiens

<220>
<223>  Tim1 binding domain

<220> 
<221> SIGNAL
<222> (1)...(20)

<400>  28

Met His Pro Gln Val Val Ile Leu Ser Leu Ile Leu His Leu Ala Asp 
1               5                   10                  15      


Ser Val Ala Gly Ser Val Lys Val Gly Gly Glu Ala Gly Pro Ser Val 
            20                  25                  30          


Thr Leu Pro Cys His Tyr Ser Gly Ala Val Thr Ser Met Cys Trp Asn 
        35                  40                  45              


Arg Gly Ser Cys Ser Leu Phe Thr Cys Gln Asn Gly Ile Val Trp Thr 
    50                  55                  60                  


Asn Gly Thr His Val Thr Tyr Arg Lys Asp Thr Arg Tyr Lys Leu Leu 
65                  70                  75                  80  


Gly Asp Leu Ser Arg Arg Asp Val Ser Leu Thr Ile Glu Asn Thr Ala 
                85                  90                  95      


Val Ser Asp Ser Gly Val Tyr Cys Cys Arg Val Glu His Arg Gly Trp 
            100                 105                 110         


Phe Asn Asp Met Lys Ile Thr Val Ser Leu Glu Ile Val Pro Pro Lys 
        115                 120                 125             


Val Thr Thr Thr Pro Ile Val Thr Thr Val Pro Thr Val Thr Thr Val 
    130                 135                 140                 


Arg Thr Ser Thr Thr Val Pro Thr Thr Thr Thr Val Pro Thr Thr Thr 
145                 150                 155                 160 


Val Pro Thr Thr Met Ser Ile Pro Thr Thr Thr Thr Val Leu Thr Thr 
                165                 170                 175     


Met Thr Val Ser Thr Thr Thr Ser Val Pro Thr Thr Thr Ser Ile Pro 
            180                 185                 190         


Thr Thr Thr Ser Val Pro Val Thr Thr Thr Val Ser Thr Phe Val Pro 
        195                 200                 205             


Pro Met Pro Leu Pro Arg Gln Asn His Glu Pro Val Ala Thr Ser Pro 
    210                 215                 220                 


Ser Ser Pro Gln Pro Ala Glu Thr His Pro Thr Thr Leu Gln Gly Ala 
225                 230                 235                 240 


Ile Arg Arg Glu Pro Thr Ser Ser Pro Leu Tyr Ser Tyr Thr Thr Asp 
                245                 250                 255     


Gly Asn Asp Thr Val Thr Glu Ser Ser Asp Gly Leu Trp Asn Asn Asn 
            260                 265                 270         


Gln Thr Gln Leu Phe Leu Glu His Ser Leu Leu Thr Ala Asn Thr Thr 
        275                 280                 285             


Lys Gly 
    290 


<210>  29
<211>  314
<212>  PRT
<213>  Homo sapiens

<220>
<223>  Tim4 binding domain

<220> 
<221> SIGNAL
<222> (1)...(24)

<400>  29

Met Ser Lys Glu Pro Leu Ile Leu Trp Leu Met Ile Glu Phe Trp Trp 
1               5                   10                  15      


Leu Tyr Leu Thr Pro Val Thr Ser Glu Thr Val Val Thr Glu Val Leu 
            20                  25                  30          


Gly His Arg Val Thr Leu Pro Cys Leu Tyr Ser Ser Trp Ser His Asn 
        35                  40                  45              


Ser Asn Ser Met Cys Trp Gly Lys Asp Gln Cys Pro Tyr Ser Gly Cys 
    50                  55                  60                  


Lys Glu Ala Leu Ile Arg Thr Asp Gly Met Arg Val Thr Ser Arg Lys 
65                  70                  75                  80  


Ser Ala Lys Tyr Arg Leu Gln Gly Thr Ile Pro Arg Gly Asp Val Ser 
                85                  90                  95      


Leu Thr Ile Leu Asn Pro Ser Glu Ser Asp Ser Gly Val Tyr Cys Cys 
            100                 105                 110         


Arg Ile Glu Val Pro Gly Trp Phe Asn Asp Val Lys Ile Asn Val Arg 
        115                 120                 125             


Leu Asn Leu Gln Arg Ala Ser Thr Thr Thr His Arg Thr Ala Thr Thr 
    130                 135                 140                 


Thr Thr Arg Arg Thr Thr Thr Thr Ser Pro Thr Thr Thr Arg Gln Met 
145                 150                 155                 160 


Thr Thr Thr Pro Ala Ala Leu Pro Thr Thr Val Val Thr Thr Pro Asp 
                165                 170                 175     


Leu Thr Thr Gly Thr Pro Leu Gln Met Thr Thr Ile Ala Val Phe Thr 
            180                 185                 190         


Thr Ala Asn Thr Cys Leu Ser Leu Thr Pro Ser Thr Leu Pro Glu Glu 
        195                 200                 205             


Ala Thr Gly Leu Leu Thr Pro Glu Pro Ser Lys Glu Gly Pro Ile Leu 
    210                 215                 220                 


Thr Ala Glu Ser Glu Thr Val Leu Pro Ser Asp Ser Trp Ser Ser Val 
225                 230                 235                 240 


Glu Ser Thr Ser Ala Asp Thr Val Leu Leu Thr Ser Lys Glu Ser Lys 
                245                 250                 255     


Val Trp Asp Leu Pro Ser Thr Ser His Val Ser Met Trp Lys Thr Ser 
            260                 265                 270         


Asp Ser Val Ser Ser Pro Gln Pro Gly Ala Ser Asp Thr Ala Val Pro 
        275                 280                 285             


Glu Gln Asn Lys Thr Thr Lys Thr Gly Gln Met Asp Gly Ile Pro Met 
    290                 295                 300                 


Ser Met Lys Asn Glu Met Pro Ile Ser Gln 
305                 310                 


<210>  30
<211>  161
<212>  PRT
<213>  Homo sapiens

<220>
<223>  FA58C2 binding domain

<400>  30

Leu Asn Gly Cys Ala Asn Pro Leu Gly Leu Lys Asn Asn Ser Ile Pro 
1               5                   10                  15      


Asp Lys Gln Ile Thr Ala Ser Ser Ser Tyr Lys Thr Trp Gly Leu His 
            20                  25                  30          


Leu Phe Ser Trp Asn Pro Ser Tyr Ala Arg Leu Asp Lys Gln Gly Asn 
        35                  40                  45              


Phe Asn Ala Trp Val Ala Gly Ser Tyr Gly Asn Asp Gln Trp Leu Gln 
    50                  55                  60                  


Val Asp Leu Gly Ser Ser Lys Glu Val Thr Gly Ile Ile Thr Gln Gly 
65                  70                  75                  80  


Ala Arg Asn Phe Gly Ser Val Gln Phe Val Ala Ser Tyr Lys Val Ala 
                85                  90                  95      


Tyr Ser Asn Asp Ser Ala Asn Trp Thr Glu Tyr Gln Asp Pro Arg Thr 
            100                 105                 110         


Gly Ser Ser Lys Ile Phe Pro Gly Asn Trp Asp Asn His Ser His Lys 
        115                 120                 125             


Lys Asn Leu Phe Glu Thr Pro Ile Leu Ala Arg Tyr Val Arg Ile Leu 
    130                 135                 140                 


Pro Val Ala Trp His Asn Arg Ile Ala Leu Arg Leu Glu Leu Leu Gly 
145                 150                 155                 160 


Cys 
    

<210>  31
<211>  292
<212>  PRT
<213>  Homo sapiens

<220>
<223>  FcgammaRI binding domain

<220> 
<221> SIGNAL
<222> (1)...(15)

<400>  31

Met Trp Phe Leu Thr Thr Leu Leu Leu Trp Val Pro Val Asp Gly Gln 
1               5                   10                  15      


Val Asp Thr Thr Lys Ala Val Ile Thr Leu Gln Pro Pro Trp Val Ser 
            20                  25                  30          


Val Phe Gln Glu Glu Thr Val Thr Leu His Cys Glu Val Leu His Leu 
        35                  40                  45              


Pro Gly Ser Ser Ser Thr Gln Trp Phe Leu Asn Gly Thr Ala Thr Gln 
    50                  55                  60                  


Thr Ser Thr Pro Ser Tyr Arg Ile Thr Ser Ala Ser Val Asn Asp Ser 
65                  70                  75                  80  


Gly Glu Tyr Arg Cys Gln Arg Gly Leu Ser Gly Arg Ser Asp Pro Ile 
                85                  90                  95      


Gln Leu Glu Ile His Arg Gly Trp Leu Leu Leu Gln Val Ser Ser Arg 
            100                 105                 110         


Val Phe Thr Glu Gly Glu Pro Leu Ala Leu Arg Cys His Ala Trp Lys 
        115                 120                 125             


Asp Lys Leu Val Tyr Asn Val Leu Tyr Tyr Arg Asn Gly Lys Ala Phe 
    130                 135                 140                 


Lys Phe Phe His Trp Asn Ser Asn Leu Thr Ile Leu Lys Thr Asn Ile 
145                 150                 155                 160 


Ser His Asn Gly Thr Tyr His Cys Ser Gly Met Gly Lys His Arg Tyr 
                165                 170                 175     


Thr Ser Ala Gly Ile Ser Val Thr Val Lys Glu Leu Phe Pro Ala Pro 
            180                 185                 190         


Val Leu Asn Ala Ser Val Thr Ser Pro Leu Leu Glu Gly Asn Leu Val 
        195                 200                 205             


Thr Leu Ser Cys Glu Thr Lys Leu Leu Leu Gln Arg Pro Gly Leu Gln 
    210                 215                 220                 


Leu Tyr Phe Ser Phe Tyr Met Gly Ser Lys Thr Leu Arg Gly Arg Asn 
225                 230                 235                 240 


Thr Ser Ser Glu Tyr Gln Ile Leu Thr Ala Arg Arg Glu Asp Ser Gly 
                245                 250                 255     


Leu Tyr Trp Cys Glu Ala Ala Thr Glu Asp Gly Asn Val Leu Lys Arg 
            260                 265                 270         


Ser Pro Glu Leu Glu Leu Gln Val Leu Gly Leu Gln Leu Pro Thr Pro 
        275                 280                 285             


Val Trp Phe His 
    290         


<210>  32
<211>  94
<212>  PRT
<213>  Homo sapiens

<220>
<223>  Gas6 binding domain

<220> 
<221> SIGNAL
<222> (1)...(30)


<400>  32

Met Ala Pro Ser Leu Ser Pro Gly Pro Ala Ala Leu Arg Arg Ala Pro 
1               5                   10                  15      


Gln Leu Leu Leu Leu Leu Leu Ala Ala Glu Cys Ala Leu Ala Ala Leu 
            20                  25                  30          


Leu Pro Ala Arg Glu Ala Thr Gln Phe Leu Arg Pro Arg Gln Arg Arg 
        35                  40                  45              


Ala Phe Gln Val Phe Glu Glu Ala Lys Gln Gly His Leu Glu Arg Glu 
    50                  55                  60                  


Cys Val Glu Glu Leu Cys Ser Arg Glu Glu Ala Arg Glu Val Phe Glu 
65                  70                  75                  80  


Asn Asp Pro Glu Thr Asp Tyr Phe Tyr Pro Arg Tyr Leu Asp 
                85                  90                  


<210>  33
<211>  87
<212>  PRT
<213>  Homo sapiens

<220>
<223>  Protein S binding domain

<220> 
<221> SIGNAL
<222> (1)...(24)

<400>  33

Met Arg Val Leu Gly Gly Arg Cys Gly Ala Leu Leu Ala Cys Leu Leu 
1               5                   10                  15      


Leu Val Leu Pro Val Ser Glu Ala Asn Phe Leu Ser Lys Gln Gln Ala 
            20                  25                  30          


Ser Gln Val Leu Val Arg Lys Arg Arg Ala Asn Ser Leu Leu Glu Glu 
        35                  40                  45              


Thr Lys Gln Gly Asn Leu Glu Arg Glu Cys Ile Glu Glu Leu Cys Asn 
    50                  55                  60                  


Lys Glu Glu Ala Arg Glu Val Phe Glu Asn Asp Pro Glu Thr Asp Tyr 
65                  70                  75                  80  


Phe Tyr Pro Lys Tyr Leu Val 
                85          


<210>  34
<211>  202
<212>  PRT
<213>  Homo sapiens

<220>
<223>  Tim3 binding domain

<220> 
<221> SIGNAL
<222> (1)...(21)

<400>  34

Met Phe Ser His Leu Pro Phe Asp Cys Val Leu Leu Leu Leu Leu Leu 
1               5                   10                  15      


Leu Leu Thr Arg Ser Ser Glu Val Glu Tyr Arg Ala Glu Val Gly Gln 
            20                  25                  30          


Asn Ala Tyr Leu Pro Cys Phe Tyr Thr Pro Ala Ala Pro Gly Asn Leu 
        35                  40                  45              


Val Pro Val Cys Trp Gly Lys Gly Ala Cys Pro Val Phe Glu Cys Gly 
    50                  55                  60                  


Asn Val Val Leu Arg Thr Asp Glu Arg Asp Val Asn Tyr Trp Thr Ser 
65                  70                  75                  80  


Arg Tyr Trp Leu Asn Gly Asp Phe Arg Lys Gly Asp Val Ser Leu Thr 
                85                  90                  95      


Ile Glu Asn Val Thr Leu Ala Asp Ser Gly Ile Tyr Cys Cys Arg Ile 
            100                 105                 110         


Gln Ile Pro Gly Ile Met Asn Asp Glu Lys Phe Asn Leu Lys Leu Val 
        115                 120                 125             


Ile Lys Pro Ala Lys Val Thr Pro Ala Pro Thr Arg Gln Arg Asp Phe 
    130                 135                 140                 


Thr Ala Ala Phe Pro Arg Met Leu Thr Thr Arg Gly His Gly Pro Ala 
145                 150                 155                 160 


Glu Thr Gln Thr Leu Gly Ser Leu Pro Asp Ile Asn Leu Thr Gln Ile 
                165                 170                 175     


Ser Thr Leu Ala Asn Glu Leu Arg Asp Ser Arg Leu Ala Asn Asp Leu 
            180                 185                 190         


Arg Asp Ser Gly Ala Thr Ile Arg Ile Gly 
        195                 200         


<210>  35
<211>  21
<212>  PRT
<213>  Homo sapiens

<220>
<223>  Tim1 transmembrane domain

<400>  35

Ile Tyr Ala Gly Val Cys Ile Ser Val Leu Val Leu Leu Ala Leu Leu 
1               5                   10                  15      


Gly Val Ile Ile Ala 
            20      


<210>  36
<211>  21
<212>  PRT
<213>  Homo sapiens

<220>
<223> Tim4 transmembrane domain

<400>  36

Leu Leu Met Ile Ile Ala Pro Ser Leu Gly Phe Val Leu Phe Ala Leu 
1               5                   10                  15      


Phe Val Ala Phe Leu 
            20      


<210>  37
<211>  21
<212>  PRT
<213>  Homo sapiens

<220>
<223>  FcgammaRI transmembrane domain

<400>  37

Val Leu Phe Tyr Leu Ala Val Gly Ile Met Phe Leu Val Asn Thr Val 
1               5                   10                  15      


Leu Trp Val Thr Ile 
            20      


<210>  38
<211>  21
<212>  PRT
<213>  Homo sapiens

<220>
<223>  CD8a transmembrane domain

<400>  38

Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu 
1               5                   10                  15      


Ser Leu Val Ile Thr 
            20      


<210>  39
<211>  21
<212>  PRT
<213>  Homo sapiens

<220>
<223>  MERTK transmembrane domain

<400>  39

Phe Gly Cys Phe Cys Gly Phe Ile Leu Ile Gly Leu Ile Leu Tyr Ile 
1               5                   10                  15      


Ser Leu Ala Ile Arg 
            20      


<210>  40
<211>  21
<212>  PRT
<213>  Homo sapiens

<220>
<223> Axl transmembrane domain

<400>  40

Tyr Val Leu Leu Gly Ala Val Val Ala Ala Ala Cys Val Leu Ile Leu 
1               5                   10                  15      


Ala Leu Phe Leu Val 
            20      


<210>  41
<211>  21
<212>  PRT
<213>  Homo sapiens

<220>
<223>  Tyro3 transmembrane domain

<400>  41

Val Pro Val Val Leu Gly Val Leu Thr Ala Leu Val Thr Ala Ala Ala 
1               5                   10                  15      


Leu Ala Leu Ile Leu 
            20      


<210>  42
<211>  22
<212>  PRT
<213>  Homo sapiens

<220>
<223>  CD4 transmembrane domain

<400>  42

Met Ala Leu Ile Val Leu Gly Gly Val Ala Gly Leu Leu Leu Phe Ile 
1               5                   10                  15      


Gly Leu Gly Ile Phe Phe 
            20          


<210>  43
<211>  476
<212>  PRT
<213>  Mus musculus

<220>
<223>  MERTK signaling domain

<400>  43

Ala Leu Arg Arg Arg Val Gln Glu Thr Lys Phe Gly Gly Ala Phe Ser 
1               5                   10                  15      


Glu Glu Asp Ser Gln Leu Val Val Asn Tyr Arg Ala Lys Lys Ser Phe 
            20                  25                  30          


Cys Arg Arg Ala Ile Glu Leu Thr Leu Gln Ser Leu Gly Val Ser Glu 
        35                  40                  45              


Glu Leu Gln Asn Lys Leu Glu Asp Val Val Ile Asp Arg Asn Leu Leu 
    50                  55                  60                  


Val Leu Gly Lys Val Leu Gly Glu Gly Glu Phe Gly Ser Val Met Glu 
65                  70                  75                  80  


Gly Asn Leu Lys Gln Glu Asp Gly Thr Ser Gln Lys Val Ala Val Lys 
                85                  90                  95      


Thr Met Lys Leu Asp Asn Phe Ser Gln Arg Glu Ile Glu Glu Phe Leu 
            100                 105                 110         


Ser Glu Ala Ala Cys Met Lys Asp Phe Asn His Pro Asn Val Ile Arg 
        115                 120                 125             


Leu Leu Gly Val Cys Ile Glu Leu Ser Ser Gln Gly Ile Pro Lys Pro 
    130                 135                 140                 


Met Val Ile Leu Pro Phe Met Lys Tyr Gly Asp Leu His Thr Phe Leu 
145                 150                 155                 160 


Leu Tyr Ser Arg Leu Asn Thr Gly Pro Lys Tyr Ile His Leu Gln Thr 
                165                 170                 175     


Leu Leu Lys Phe Met Met Asp Ile Ala Gln Gly Met Glu Tyr Leu Ser 
            180                 185                 190         


Asn Arg Asn Phe Leu His Arg Asp Leu Ala Ala Arg Asn Cys Met Leu 
        195                 200                 205             


Arg Asp Asp Met Thr Val Cys Val Ala Asp Phe Gly Leu Ser Lys Lys 
    210                 215                 220                 


Ile Tyr Ser Gly Asp Tyr Tyr Arg Gln Gly Arg Ile Ala Lys Met Pro 
225                 230                 235                 240 


Val Lys Trp Ile Ala Ile Glu Ser Leu Ala Asp Arg Val Tyr Thr Ser 
                245                 250                 255     


Lys Ser Asp Val Trp Ala Phe Gly Val Thr Met Trp Glu Ile Thr Thr 
            260                 265                 270         


Arg Gly Met Thr Pro Tyr Pro Gly Val Gln Asn His Glu Met Tyr Asp 
        275                 280                 285             


Tyr Leu Leu His Gly His Arg Leu Lys Gln Pro Glu Asp Cys Leu Asp 
    290                 295                 300                 


Glu Leu Tyr Asp Ile Met Tyr Ser Cys Trp Ser Ala Asp Pro Leu Asp 
305                 310                 315                 320 


Arg Pro Thr Phe Ser Val Leu Arg Leu Gln Leu Glu Lys Leu Ser Glu 
                325                 330                 335     


Ser Leu Pro Asp Ala Gln Asp Lys Glu Ser Ile Ile Tyr Ile Asn Thr 
            340                 345                 350         


Gln Leu Leu Glu Ser Cys Glu Gly Ile Ala Asn Gly Pro Ser Leu Thr 
        355                 360                 365             


Gly Leu Asp Met Asn Ile Asp Pro Asp Ser Ile Ile Ala Ser Cys Thr 
    370                 375                 380                 


Pro Gly Ala Ala Val Ser Val Val Thr Ala Glu Val His Glu Asn Asn 
385                 390                 395                 400 


Leu Arg Glu Glu Arg Tyr Ile Leu Asn Gly Gly Asn Glu Glu Trp Glu 
                405                 410                 415     


Asp Val Ser Ser Thr Pro Phe Ala Ala Val Thr Pro Glu Lys Asp Gly 
            420                 425                 430         


Val Leu Pro Glu Asp Arg Leu Thr Lys Asn Gly Val Ser Trp Ser His 
        435                 440                 445             


His Ser Thr Leu Pro Leu Gly Ser Pro Ser Pro Asp Glu Leu Leu Phe 
    450                 455                 460                 


Val Asp Asp Ser Leu Glu Asp Ser Glu Val Leu Met 
465                 470                 475     


<210>  44
<211>  422
<212>  PRT
<213>  Homo sapiens

<220>
<223>  Axl signaling domain

<400>  44

His Arg Arg Lys Lys Glu Thr Arg Tyr Gly Glu Val Phe Glu Pro Thr 
1               5                   10                  15      


Val Glu Arg Gly Glu Leu Val Val Arg Tyr Arg Val Arg Lys Ser Tyr 
            20                  25                  30          


Ser Arg Arg Thr Thr Glu Ala Thr Leu Asn Ser Leu Gly Ile Ser Glu 
        35                  40                  45              


Glu Leu Lys Glu Lys Leu Arg Asp Val Met Val Asp Arg His Lys Val 
    50                  55                  60                  


Ala Leu Gly Lys Thr Leu Gly Glu Gly Glu Phe Gly Ala Val Met Glu 
65                  70                  75                  80  


Gly Gln Leu Asn Gln Asp Asp Ser Ile Leu Lys Val Ala Val Lys Thr 
                85                  90                  95      


Met Lys Ile Ala Ile Cys Thr Arg Ser Glu Leu Glu Asp Phe Leu Ser 
            100                 105                 110         


Glu Ala Val Cys Met Lys Glu Phe Asp His Pro Asn Val Met Arg Leu 
        115                 120                 125             


Ile Gly Val Cys Phe Gln Gly Ser Glu Arg Glu Ser Phe Pro Ala Pro 
    130                 135                 140                 


Val Val Ile Leu Pro Phe Met Lys His Gly Asp Leu His Ser Phe Leu 
145                 150                 155                 160 


Leu Tyr Ser Arg Leu Gly Asp Gln Pro Val Tyr Leu Pro Thr Gln Met 
                165                 170                 175     


Leu Val Lys Phe Met Ala Asp Ile Ala Ser Gly Met Glu Tyr Leu Ser 
            180                 185                 190         


Thr Lys Arg Phe Ile His Arg Asp Leu Ala Ala Arg Asn Cys Met Leu 
        195                 200                 205             


Asn Glu Asn Met Ser Val Cys Val Ala Asp Phe Gly Leu Ser Lys Lys 
    210                 215                 220                 


Ile Tyr Asn Gly Asp Tyr Tyr Arg Gln Gly Arg Ile Ala Lys Met Pro 
225                 230                 235                 240 


Val Lys Trp Ile Ala Ile Glu Ser Leu Ala Asp Arg Val Tyr Thr Ser 
                245                 250                 255     


Lys Ser Asp Val Trp Ser Phe Gly Val Thr Met Trp Glu Ile Ala Thr 
            260                 265                 270         


Arg Gly Gln Thr Pro Tyr Pro Gly Val Glu Asn Ser Glu Ile Tyr Asp 
        275                 280                 285             


Tyr Leu Arg Gln Gly Asn Arg Leu Lys Gln Pro Ala Asp Cys Leu Asp 
    290                 295                 300                 


Gly Leu Tyr Ala Leu Met Ser Arg Cys Trp Glu Leu Asn Pro Gln Asp 
305                 310                 315                 320 


Arg Pro Ser Phe Thr Glu Leu Arg Glu Asp Leu Glu Asn Thr Leu Lys 
                325                 330                 335     


Ala Leu Pro Pro Ala Gln Glu Pro Asp Glu Ile Leu Tyr Val Asn Met 
            340                 345                 350         


Asp Glu Gly Gly Gly Tyr Pro Glu Pro Pro Gly Ala Ala Gly Gly Ala 
        355                 360                 365             


Asp Pro Pro Thr Gln Pro Asp Pro Lys Asp Ser Cys Ser Cys Leu Thr 
    370                 375                 380                 


Ala Ala Glu Val His Pro Ala Gly Arg Tyr Val Leu Cys Pro Ser Thr 
385                 390                 395                 400 


Thr Pro Ser Pro Ala Gln Pro Ala Asp Arg Gly Ser Pro Ala Ala Pro 
                405                 410                 415     


Gly Gln Glu Asp Gly Ala 
            420         


<210>  45
<211>  440
<212>  PRT
<213>  Homo sapiens

<220>
<223>  Tyro3 signaling domain

<400>  45

Leu Arg Lys Arg Arg Lys Glu Thr Arg Phe Gly Gln Ala Phe Asp Ser 
1               5                   10                  15      


Val Met Ala Arg Gly Glu Pro Ala Val His Phe Arg Ala Ala Arg Ser 
            20                  25                  30          


Phe Asn Arg Glu Arg Pro Glu Arg Ile Glu Ala Thr Leu Asp Ser Leu 
        35                  40                  45              


Gly Ile Ser Asp Glu Leu Lys Glu Lys Leu Glu Asp Val Leu Ile Pro 
    50                  55                  60                  


Glu Gln Gln Phe Thr Leu Gly Arg Met Leu Gly Lys Gly Glu Phe Gly 
65                  70                  75                  80  


Ser Val Arg Glu Ala Gln Leu Lys Gln Glu Asp Gly Ser Phe Val Lys 
                85                  90                  95      


Val Ala Val Lys Met Leu Lys Ala Asp Ile Ile Ala Ser Ser Asp Ile 
            100                 105                 110         


Glu Glu Phe Leu Arg Glu Ala Ala Cys Met Lys Glu Phe Asp His Pro 
        115                 120                 125             


His Val Ala Lys Leu Val Gly Val Ser Leu Arg Ser Arg Ala Lys Gly 
    130                 135                 140                 


Arg Leu Pro Ile Pro Met Val Ile Leu Pro Phe Met Lys His Gly Asp 
145                 150                 155                 160 


Leu His Ala Phe Leu Leu Ala Ser Arg Ile Gly Glu Asn Pro Phe Asn 
                165                 170                 175     


Leu Pro Leu Gln Thr Leu Ile Arg Phe Met Val Asp Ile Ala Cys Gly 
            180                 185                 190         


Met Glu Tyr Leu Ser Ser Arg Asn Phe Ile His Arg Asp Leu Ala Ala 
        195                 200                 205             


Arg Asn Cys Met Leu Ala Glu Asp Met Thr Val Cys Val Ala Asp Phe 
    210                 215                 220                 


Gly Leu Ser Arg Lys Ile Tyr Ser Gly Asp Tyr Tyr Arg Gln Gly Cys 
225                 230                 235                 240 


Ala Ser Lys Leu Pro Val Lys Trp Leu Ala Leu Glu Ser Leu Ala Asp 
                245                 250                 255     


Asn Leu Tyr Thr Val Gln Ser Asp Val Trp Ala Phe Gly Val Thr Met 
            260                 265                 270         


Trp Glu Ile Met Thr Arg Gly Gln Thr Pro Tyr Ala Gly Ile Glu Asn 
        275                 280                 285             


Ala Glu Ile Tyr Asn Tyr Leu Ile Gly Gly Asn Arg Leu Lys Gln Pro 
    290                 295                 300                 


Pro Glu Cys Met Glu Asp Val Tyr Asp Leu Met Tyr Gln Cys Trp Ser 
305                 310                 315                 320 


Ala Asp Pro Lys Gln Arg Pro Ser Phe Thr Cys Leu Arg Met Glu Leu 
                325                 330                 335     


Glu Asn Ile Leu Gly Gln Leu Ser Val Leu Ser Ala Ser Gln Asp Pro 
            340                 345                 350         


Leu Tyr Ile Asn Ile Glu Arg Ala Glu Glu Pro Thr Ala Gly Gly Ser 
        355                 360                 365             


Leu Glu Leu Pro Gly Arg Asp Gln Pro Tyr Ser Gly Ala Gly Asp Gly 
    370                 375                 380                 


Ser Gly Met Gly Ala Val Gly Gly Thr Pro Ser Asp Cys Arg Tyr Ile 
385                 390                 395                 400 


Leu Thr Pro Gly Gly Leu Ala Glu Gln Pro Gly Gln Ala Glu His Gln 
                405                 410                 415     


Pro Glu Ser Pro Leu Asn Glu Thr Gln Arg Leu Leu Leu Leu Gln Gln 
            420                 425                 430         


Gly Leu Leu Pro His Ser Ser Cys 
        435                 440 


<210>  46
<211>  261
<212>  PRT
<213>  Homo sapiens

<220>
<223>  Syk signaling domain

<400>  46

Thr Leu Glu Asp Lys Glu Leu Gly Ser Gly Asn Phe Gly Thr Val Lys 
1               5                   10                  15      


Lys Gly Tyr Tyr Gln Met Lys Lys Val Val Lys Thr Val Ala Val Lys 
            20                  25                  30          


Ile Leu Lys Asn Glu Ala Asn Asp Pro Ala Leu Lys Asp Glu Leu Leu 
        35                  40                  45              


Ala Glu Ala Asn Val Met Gln Gln Leu Asp Asn Pro Tyr Ile Val Arg 
    50                  55                  60                  


Met Ile Gly Ile Cys Glu Ala Glu Ser Trp Met Leu Val Met Glu Met 
65                  70                  75                  80  


Ala Glu Leu Gly Pro Leu Asn Lys Tyr Leu Gln Gln Asn Arg His Val 
                85                  90                  95      


Lys Asp Lys Asn Ile Ile Glu Leu Val His Gln Val Ser Met Gly Met 
            100                 105                 110         


Lys Tyr Leu Glu Glu Ser Asn Phe Val His Arg Asp Leu Ala Ala Arg 
        115                 120                 125             


Asn Val Leu Leu Val Thr Gln His Tyr Ala Lys Ile Ser Asp Phe Gly 
    130                 135                 140                 


Leu Ser Lys Ala Leu Arg Ala Asp Glu Asn Tyr Tyr Lys Ala Gln Thr 
145                 150                 155                 160 


His Gly Lys Trp Pro Val Lys Trp Tyr Ala Pro Glu Cys Ile Asn Tyr 
                165                 170                 175     


Tyr Lys Phe Ser Ser Lys Ser Asp Val Trp Ser Phe Gly Val Leu Met 
            180                 185                 190         


Trp Glu Ala Phe Ser Tyr Gly Gln Lys Pro Tyr Arg Gly Met Lys Gly 
        195                 200                 205             


Ser Glu Val Thr Ala Met Leu Glu Lys Gly Glu Arg Met Gly Cys Pro 
    210                 215                 220                 


Ala Gly Cys Pro Arg Glu Met Tyr Asp Leu Met Asn Leu Cys Trp Thr 
225                 230                 235                 240 


Tyr Asp Val Glu Asn Arg Pro Gly Phe Ala Ala Val Glu Leu Arg Leu 
                245                 250                 255     


Arg Asn Tyr Tyr Tyr 
            260     


<210>  47
<211>  263
<212>  PRT
<213>  Homo sapiens

<220>
<223>  Zap70 signaling domain

<400>  47

Leu Ile Ala Asp Ile Glu Leu Gly Cys Gly Asn Phe Gly Ser Val Arg 
1               5                   10                  15      


Gln Gly Val Tyr Arg Met Arg Lys Lys Gln Ile Asp Val Ala Ile Lys 
            20                  25                  30          


Val Leu Lys Gln Gly Thr Glu Lys Ala Asp Thr Glu Glu Met Met Arg 
        35                  40                  45              


Glu Ala Gln Ile Met His Gln Leu Asp Asn Pro Tyr Ile Val Arg Leu 
    50                  55                  60                  


Ile Gly Val Cys Gln Ala Glu Ala Leu Met Leu Val Met Glu Met Ala 
65                  70                  75                  80  


Gly Gly Gly Pro Leu His Lys Phe Leu Val Gly Lys Arg Glu Glu Ile 
                85                  90                  95      


Pro Val Ser Asn Val Ala Glu Leu Leu His Gln Val Ser Met Gly Met 
            100                 105                 110         


Lys Tyr Leu Glu Glu Lys Asn Phe Val His Arg Asp Leu Ala Ala Arg 
        115                 120                 125             


Asn Val Leu Leu Val Asn Arg His Tyr Ala Lys Ile Ser Asp Phe Gly 
    130                 135                 140                 


Leu Ser Lys Ala Leu Gly Ala Asp Asp Ser Tyr Tyr Thr Ala Arg Ser 
145                 150                 155                 160 


Ala Gly Lys Trp Pro Leu Lys Trp Tyr Ala Pro Glu Cys Ile Asn Phe 
                165                 170                 175     


Arg Lys Phe Ser Ser Arg Ser Asp Val Trp Ser Tyr Gly Val Thr Met 
            180                 185                 190         


Trp Glu Ala Leu Ser Tyr Gly Gln Lys Pro Tyr Lys Lys Met Lys Gly 
        195                 200                 205             


Pro Glu Val Met Ala Phe Ile Glu Gln Gly Lys Arg Met Glu Cys Pro 
    210                 215                 220                 


Pro Glu Cys Pro Pro Glu Leu Tyr Ala Leu Met Ser Asp Cys Trp Ile 
225                 230                 235                 240 


Tyr Lys Trp Glu Asp Arg Pro Asp Phe Leu Thr Val Glu Gln Arg Met 
                245                 250                 255     


Arg Ala Cys Tyr Tyr Ser Leu 
            260             


<210>  48
<211>  61
<212>  PRT
<213>  Homo sapiens

<220>
<223>  FcgammaRI signaling domain

<400>  48

Arg Lys Glu Leu Lys Arg Lys Lys Lys Trp Asp Leu Glu Ile Ser Leu 
1               5                   10                  15      


Asp Ser Gly His Glu Lys Lys Val Ile Ser Ser Leu Gln Glu Asp Arg 
            20                  25                  30          


His Leu Glu Glu Glu Leu Lys Cys Gln Glu Gln Lys Glu Glu Gln Leu 
        35                  40                  45              


Gln Glu Gly Val His Arg Lys Glu Pro Gln Gly Ala Thr 
    50                  55                  60      


<210>  49
<211>  77
<212>  PRT
<213>  Homo sapiens

<220>
<223> FcgammaR2A signaling domain

<400>  49

Cys Arg Lys Lys Arg Ile Ser Ala Asn Ser Thr Asp Pro Val Lys Ala 
1               5                   10                  15      


Ala Gln Phe Glu Pro Pro Gly Arg Gln Met Ile Ala Ile Arg Lys Arg 
            20                  25                  30          


Gln Leu Glu Glu Thr Asn Asn Asp Tyr Glu Thr Ala Asp Gly Gly Tyr 
        35                  40                  45              


Met Thr Leu Asn Pro Arg Ala Pro Thr Asp Asp Asp Lys Asn Ile Tyr 
    50                  55                  60                  


Leu Thr Leu Pro Pro Asn Asp His Val Asn Ser Asn Asn 
65                  70                  75          


<210>  50
<211>  77
<212>  PRT
<213>  Homo sapiens

<220>
<223>  FcgammaR2C signaling domain

<400>  50

Cys Arg Lys Lys Arg Ile Ser Ala Asn Ser Thr Asp Pro Val Lys Ala 
1               5                   10                  15      


Ala Gln Phe Glu Pro Pro Gly Arg Gln Met Ile Ala Ile Arg Lys Arg 
            20                  25                  30          


Gln Pro Glu Glu Thr Asn Asn Asp Tyr Glu Thr Ala Asp Gly Gly Tyr 
        35                  40                  45              


Met Thr Leu Asn Pro Arg Ala Pro Thr Asp Asp Asp Lys Asn Ile Tyr 
    50                  55                  60                  


Leu Thr Leu Pro Pro Asn Asp His Val Asn Ser Asn Asn 
65                  70                  75          


<210>  51
<211>  25
<212>  PRT
<213>  Homo sapiens

<220>
<223> FcgammaR3A signaling domain

<400>  51

Lys Thr Asn Ile Arg Ser Ser Thr Arg Asp Trp Lys Asp His Lys Phe 
1               5                   10                  15      


Lys Trp Arg Lys Asp Pro Gln Asp Lys 
            20                  25  


<210>  52
<211>  56
<212>  PRT
<213>  Mus musculus

<220>
<223>  ItgB5 signaling domain

<400>  52

Lys Leu Leu Val Thr Ile His Asp Arg Arg Glu Phe Ala Lys Phe Gln 
1               5                   10                  15      


Ser Glu Arg Ser Arg Ala Arg Tyr Glu Met Ala Ser Asn Pro Leu Tyr 
            20                  25                  30          


Arg Lys Pro Ile Ser Thr His Thr Val Asp Phe Ala Phe Asn Lys Phe 
        35                  40                  45              


Asn Lys Ser Tyr Asn Gly Ser Val 
    50                  55      


<210>  53
<211>  296
<212>  PRT
<213>  Homo sapiens

<220>
<223>  MyD88 signaling domain

<400>  53

Met Ala Ala Gly Gly Pro Gly Ala Gly Ser Ala Ala Pro Val Ser Ser 
1               5                   10                  15      


Thr Ser Ser Leu Pro Leu Ala Ala Leu Asn Met Arg Val Arg Arg Arg 
            20                  25                  30          


Leu Ser Leu Phe Leu Asn Val Arg Thr Gln Val Ala Ala Asp Trp Thr 
        35                  40                  45              


Ala Leu Ala Glu Glu Met Asp Phe Glu Tyr Leu Glu Ile Arg Gln Leu 
    50                  55                  60                  


Glu Thr Gln Ala Asp Pro Thr Gly Arg Leu Leu Asp Ala Trp Gln Gly 
65                  70                  75                  80  


Arg Pro Gly Ala Ser Val Gly Arg Leu Leu Glu Leu Leu Thr Lys Leu 
                85                  90                  95      


Gly Arg Asp Asp Val Leu Leu Glu Leu Gly Pro Ser Ile Glu Glu Asp 
            100                 105                 110         


Cys Gln Lys Tyr Ile Leu Lys Gln Gln Gln Glu Glu Ala Glu Lys Pro 
        115                 120                 125             


Leu Gln Val Ala Ala Val Asp Ser Ser Val Pro Arg Thr Ala Glu Leu 
    130                 135                 140                 


Ala Gly Ile Thr Thr Leu Asp Asp Pro Leu Gly His Met Pro Glu Arg 
145                 150                 155                 160 


Phe Asp Ala Phe Ile Cys Tyr Cys Pro Ser Asp Ile Gln Phe Val Gln 
                165                 170                 175     


Glu Met Ile Arg Gln Leu Glu Gln Thr Asn Tyr Arg Leu Lys Leu Cys 
            180                 185                 190         


Val Ser Asp Arg Asp Val Leu Pro Gly Thr Cys Val Trp Ser Ile Ala 
        195                 200                 205             


Ser Glu Leu Ile Glu Lys Arg Cys Arg Arg Met Val Val Val Val Ser 
    210                 215                 220                 


Asp Asp Tyr Leu Gln Ser Lys Glu Cys Asp Phe Gln Thr Lys Phe Ala 
225                 230                 235                 240 


Leu Ser Leu Ser Pro Gly Ala His Gln Lys Arg Leu Ile Pro Ile Lys 
                245                 250                 255     


Tyr Lys Ala Met Lys Lys Glu Phe Pro Ser Ile Leu Arg Phe Ile Thr 
            260                 265                 270         


Val Cys Asp Tyr Thr Asn Pro Cys Thr Lys Ser Trp Phe Trp Thr Arg 
        275                 280                 285             


Leu Ala Lys Ala Leu Ser Leu Pro 
    290                 295     


<210>  54
<211>  522
<212>  PRT
<213>  Homo sapiens

<220>
<223>  Traf6 signaling domain

<400>  54

Met Ser Leu Leu Asn Cys Glu Asn Ser Cys Gly Ser Ser Gln Ser Glu 
1               5                   10                  15      


Ser Asp Cys Cys Val Ala Met Ala Ser Ser Cys Ser Ala Val Thr Lys 
            20                  25                  30          


Asp Asp Ser Val Gly Gly Thr Ala Ser Thr Gly Asn Leu Ser Ser Ser 
        35                  40                  45              


Phe Met Glu Glu Ile Gln Gly Tyr Asp Val Glu Phe Asp Pro Pro Leu 
    50                  55                  60                  


Glu Ser Lys Tyr Glu Cys Pro Ile Cys Leu Met Ala Leu Arg Glu Ala 
65                  70                  75                  80  


Val Gln Thr Pro Cys Gly His Arg Phe Cys Lys Ala Cys Ile Ile Lys 
                85                  90                  95      


Ser Ile Arg Asp Ala Gly His Lys Cys Pro Val Asp Asn Glu Ile Leu 
            100                 105                 110         


Leu Glu Asn Gln Leu Phe Pro Asp Asn Phe Ala Lys Arg Glu Ile Leu 
        115                 120                 125             


Ser Leu Met Val Lys Cys Pro Asn Glu Gly Cys Leu His Lys Met Glu 
    130                 135                 140                 


Leu Arg His Leu Glu Asp His Gln Ala His Cys Glu Phe Ala Leu Met 
145                 150                 155                 160 


Asp Cys Pro Gln Cys Gln Arg Pro Phe Gln Lys Phe His Ile Asn Ile 
                165                 170                 175     


His Ile Leu Lys Asp Cys Pro Arg Arg Gln Val Ser Cys Asp Asn Cys 
            180                 185                 190         


Ala Ala Ser Met Ala Phe Glu Asp Lys Glu Ile His Asp Gln Asn Cys 
        195                 200                 205             


Pro Leu Ala Asn Val Ile Cys Glu Tyr Cys Asn Thr Ile Leu Ile Arg 
    210                 215                 220                 


Glu Gln Met Pro Asn His Tyr Asp Leu Asp Cys Pro Thr Ala Pro Ile 
225                 230                 235                 240 


Pro Cys Thr Phe Ser Thr Phe Gly Cys His Glu Lys Met Gln Arg Asn 
                245                 250                 255     


His Leu Ala Arg His Leu Gln Glu Asn Thr Gln Ser His Met Arg Met 
            260                 265                 270         


Leu Ala Gln Ala Val His Ser Leu Ser Val Ile Pro Asp Ser Gly Tyr 
        275                 280                 285             


Ile Ser Glu Val Arg Asn Phe Gln Glu Thr Ile His Gln Leu Glu Gly 
    290                 295                 300                 


Arg Leu Val Arg Gln Asp His Gln Ile Arg Glu Leu Thr Ala Lys Met 
305                 310                 315                 320 


Glu Thr Gln Ser Met Tyr Val Ser Glu Leu Lys Arg Thr Ile Arg Thr 
                325                 330                 335     


Leu Glu Asp Lys Val Ala Glu Ile Glu Ala Gln Gln Cys Asn Gly Ile 
            340                 345                 350         


Tyr Ile Trp Lys Ile Gly Asn Phe Gly Met His Leu Lys Cys Gln Glu 
        355                 360                 365             


Glu Glu Lys Pro Val Val Ile His Ser Pro Gly Phe Tyr Thr Gly Lys 
    370                 375                 380                 


Pro Gly Tyr Lys Leu Cys Met Arg Leu His Leu Gln Leu Pro Thr Ala 
385                 390                 395                 400 


Gln Arg Cys Ala Asn Tyr Ile Ser Leu Phe Val His Thr Met Gln Gly 
                405                 410                 415     


Glu Tyr Asp Ser His Leu Pro Trp Pro Phe Gln Gly Thr Ile Arg Leu 
            420                 425                 430         


Thr Ile Leu Asp Gln Ser Glu Ala Pro Val Arg Gln Asn His Glu Glu 
        435                 440                 445             


Ile Met Asp Ala Lys Pro Glu Leu Leu Ala Phe Gln Arg Pro Thr Ile 
    450                 455                 460                 


Pro Arg Asn Pro Lys Gly Phe Gly Tyr Val Thr Phe Met His Leu Glu 
465                 470                 475                 480 


Ala Leu Arg Gln Arg Thr Phe Ile Lys Asp Asp Thr Leu Leu Val Arg 
                485                 490                 495     


Cys Glu Val Ser Thr Arg Phe Asp Met Gly Ser Leu Arg Arg Glu Gly 
            500                 505                 510         


Phe Gln Pro Arg Ser Thr Asp Ala Gly Val 
        515                 520         


<210>  55
<211>  138
<212>  DNA
<213>  Homo sapiens

<220>
<223>  MRC1 signaling domain

<400>  55
tataagaaac ggcgcgttca tcttcctcag gagggggcat ttgaaaatac gttgtacttc       60

aacagccaga gcagtccagg tacgtctgat atgaaggatt tggtggggaa cattgaacag      120

aacgagcata gcgttata                                                    138


<210>  56
<211>  46
<212>  PRT
<213>  Homo sapiens

<220>
<223> MRC1 signaling domain

<400>  56

Tyr Lys Lys Arg Arg Val His Leu Pro Gln Glu Gly Ala Phe Glu Asn 
1               5                   10                  15      


Thr Leu Tyr Phe Asn Ser Gln Ser Ser Pro Gly Thr Ser Asp Met Lys 
            20                  25                  30          


Asp Leu Val Gly Asn Ile Glu Gln Asn Glu His Ser Val Ile 
        35                  40                  45      


<210> 57
<211> 1080
<212> DNA
<213> Mus musculus

<220>
<223> TIM4 extracellular and transmembrane domains

<400> 57
ttctctaggc gccggaattc gccaccatgt ctaaaggtct tcttctgctg tggctggtta      60
ctgaactgtg gtggttgtat ctcactcctg cagcaagtga ggataccatc attggtttct     120
tggggcagcc cgtcaccctc ccttgtcact accttagctg gagccagagc agaaatagta     180
tgtgttgggg taagggctcc tgtcctaata gcaaatgtaa tgcagagctc ttgcgaacag     240
acgggacacg gatcatcagt agaaagtcta ctaagtatac cttgcttggg aaggtacaat     300
ttggggaagt gtccctcact attagtaata caaatagagg tgacagcgga gtctattgct     360
gtagaataga agtaccaggt tggtttaacg atgtcaaaaa aaatgtacgg ctcgaattga     420
ggagggctac cactaccaag aaaccaacta caaccacccg ccccactaca accccttacg     480
tcaccacaac aacccctgaa ctgctgccca caactgtgat gaccaccagt gttcttccca     540
ctaccactcc tccccagacc ctggctacta ccgctttctc aacagccgta actacttgtc     600
cctcaactac ccctgggtca ttcagtcagg aaactacaaa ggggtccgct ttcactactg     660
agtcagaaac cctccctgct tctaatcact ctcaacgcag catgatgaca atatcaactg     720
acatcgctgt tctgagacca actggaagca atcccggtat cttgccctcc acatctcagc     780
tgacaacaca aaaaactacc ctgaccacat cagaatccct tcagaagaca actaagtccc     840
accaaatcaa ttcccgacag actattctta taatagcctg ttgtgtgggg tttgtgctga     900
tggttttgtt gttcctggct tttttgcttc gcggcaaggt gactggtgcc aactgtctcc     960
aaaggcacaa aaggccagac aatacggaag attctgattc cgtgcttaac gatatgagcc    1020
acgggcggga cgatgaggat ggtatattca ccttgtgagc ggccgcccct ctccctcccc    1080

<210> 58
<211> 1428
<212> DNA
<213> Mus musculus

<220> 
<223> MERTK signaling domain

<400> 58
gctcttagga ggagggtgca ggagacaaag tttggtgggg ctttctcaga ggaggatagc      60
cagctcgttg taaactaccg ggccaagaaa tccttttgca gaagagcaat tgaacttaca     120
ttgcaaagcc tcggagtgtc tgaggagctt cagaataaac ttgaggacgt ggtcatcgat     180
cgcaaccttc ttgtgctggg gaaggtcttg ggagagggag agttcgggtc cgtgatggaa     240
ggtaacctta aacaagagga tggaactagc caaaaagtcg ccgtaaagac tatgaagctg     300
gataatttta gtcagcggga aattgaggaa tttctttcag aggccgcttg catgaaggat     360
ttcaaccatc ccaatgttat caggctcctt ggtgtctgta tcgagcttag ttcccagggc     420
atacctaaac ctatggttat actgcctttc atgaagtatg gtgatctgca cacctttctt     480
ctctactccc ggcttaatac cgggccaaag tatatccacc tccaaaccct cttgaagttc     540
atgatggaca tagcacaggg gatggagtac ctttctaata ggaattttct tcacagggat     600
ttggccgccc gaaattgtat gctcagagat gatatgactg tttgcgtcgc agattttgga     660
cttagcaaga aaatctacag tggtgattac tacagacagg gacgcattgc aaagatgcct     720
gtgaagtgga tagccatcga atcactggcc gatagggttt atacttccaa atccgatgtt     780
tgggcctttg gtgtgactat gtgggaaata acaacacggg ggatgactcc ttatcccggt     840
gttcaaaatc atgagatgta cgattatctc ctccacgggc accgacttaa acagcccgag     900
gactgcctgg acgaactgta tgacattatg tactcttgtt ggagcgctga tccattggac     960
cggcccactt tttccgtgct gcgacttcag ctggagaagc tgagtgagtc tctgcctgac    1020
gctcaggata aagagtcaat tatatacatc aacactcagc tccttgaatc ctgtgagggg    1080
atcgcaaacg gaccttcact cactggcttg gacatgaata ttgatcccga ctccattatt    1140
gcttcctgta cacctggagc agctgtgagt gtggtaaccg ctgaggttca tgaaaataac    1200
ttgcgcgaag aaaggtatat actgaatggg ggaaacgagg aatgggaaga cgtatccagt    1260
accccatttg ctgctgtgac ccccgagaag gatggggttc tgccagaaga tagactcacc    1320
aaaaatggtg tttcctggag tcaccattcc acacttcccc ttggcagtcc aagccctgac    1380
gaactccttt ttgtagatga cagccttgag gacagcgaag tgctgatg                 1428

<210> 59
<211> 2100
<212> DNA
<213> Artificial Sequence

<220> 
<223> FA58C2-IgG4-CD28-MERTK CER03 chimeric engulfment
      receptor

<400> 59
atgttgctgc tcgttacgtc tctgctcctg tgcgaactgc cgcaccccgc cttcctcctg      60
attccgctga acggctgcgc taatccgctc ggtctgaaaa acaattctat acctgataaa     120
caaatcaccg cctcatcctc ttacaagacg tggggactcc atctcttttc ttggaaccca     180
tcttatgctc gactggacaa acaaggcaat ttcaatgcat gggtcgccgg gagttacggt     240
aacgaccaat ggctccaggt agaccttggt agtagtaagg aggtcacggg tatcatcaca     300
cagggggccc ggaatttcgg ttcagtgcag ttcgttgctt cctacaaggt cgcttattca     360
aacgatagtg ctaattggac agagtaccaa gaccctcgca cgggaagtag taagattttc     420
ccaggcaact gggataacca cagtcacaaa aaaaacttgt tcgagacgcc gatattggcg     480
agatatgtcc ggatacttcc ggtcgcgtgg cataacagaa ttgccctgag gctggaattg     540
ctgggatgcg aaagtaaata tggaccgcca tgccccccat gccccatgtt ttgggtgttg     600
gtcgtagtgg gtggagtcct cgcttgctac tcattgctcg taacggttgc ttttattata     660
ttctgggttg ctcttaggag gagggtgcag gagacaaagt ttggtggggc tttctcagag     720
gaggatagcc agctcgttgt aaactaccgg gccaagaaat ccttttgcag aagagcaatt     780
gaacttacat tgcaaagcct cggagtgtct gaggagcttc agaataaact tgaggacgtg     840
gtcatcgatc gcaaccttct tgtgctgggg aaggtcttgg gagagggaga gttcgggtcc     900
gtgatggaag gtaaccttaa acaagaggat ggaactagcc aaaaagtcgc cgtaaagact     960
atgaagctgg ataattttag tcagcgggaa attgaggaat ttctttcaga ggccgcttgc    1020
atgaaggatt tcaaccatcc caatgttatc aggctccttg gtgtctgtat cgagcttagt    1080
tcccagggca tacctaaacc tatggttata ctgcctttca tgaagtatgg tgatctgcac    1140
acctttcttc tctactcccg gcttaatacc gggccaaagt atatccacct ccaaaccctc    1200
ttgaagttca tgatggacat agcacagggg atggagtacc tttctaatag gaattttctt    1260
cacagggatt tggccgcccg aaattgtatg ctcagagatg atatgactgt ttgcgtcgca    1320
gattttggac ttagcaagaa aatctacagt ggtgattact acagacaggg acgcattgca    1380
aagatgcctg tgaagtggat agccatcgaa tcactggccg atagggttta tacttccaaa    1440
tccgatgttt gggcctttgg tgtgactatg tgggaaataa caacacgggg gatgactcct    1500
tatcccggtg ttcaaaatca tgagatgtac gattatctcc tccacgggca ccgacttaaa    1560
cagcccgagg actgcctgga cgaactgtat gacattatgt actcttgttg gagcgctgat    1620
ccattggacc ggcccacttt ttccgtgctg cgacttcagc tggagaagct gagtgagtct    1680
ctgcctgacg ctcaggataa agagtcaatt atatacatca acactcagct ccttgaatcc    1740
tgtgagggga tcgcaaacgg accttcactc actggcttgg acatgaatat tgatcccgac    1800
tccattattg cttcctgtac acctggagca gctgtgagtg tggtaaccgc tgaggttcat    1860
gaaaataact tgcgcgaaga aaggtatata ctgaatgggg gaaacgagga atgggaagac    1920
gtatccagta ccccatttgc tgctgtgacc cccgagaagg atggggttct gccagaagat    1980
agactcacca aaaatggtgt ttcctggagt caccattcca cacttcccct tggcagtcca    2040
agccctgacg aactcctttt tgtagatgac agccttgagg acagcgaagt gctgatgtga    2100

<210> 60
<211> 576
<212> DNA
<213> Homo sapiens

<220> 
<223> Rac1

<400> 60
atgcaagcca ttaagtgcgt agtagttggt gatggagccg tcggcaaaac atgcctgctg      60
atctcttata ccacaaacgc attcccgggc gagtacattc ccactgtatt tgacaactac     120
agtgctaacg tcatggtaga tggtaagccg gttaacctcg gactctggga taccgccggc     180
caggaagact atgatagact tagaccgctc agctatccgc aaaccgatgt gttcctgatt     240
tgctttagcc tggtctcccc cgcttcattt gagaatgtga gagcgaagtg gtatccagag     300
gtgcgccatc actgtccgaa cacacccatt atactcgtgg ggactaaact cgacctgagg     360
gatgacaagg acaccatcga aaaactgaaa gaaaagaaac ttacaccaat aacgtaccct     420
cagggtctgg ctatggcaaa agaaattggc gcggtgaaat acctggaatg cagtgcgctc     480
acccagcggg gcttgaagac ggtgttcgat gaggctatac gcgccgtgct gtgtccccca     540
ccagtgaaga aacgaaaacg aaagtgtctt ctcctt                               576

<210> 61
<211> 645
<212> DNA
<213> Homo sapiens

<220> 
<223> Rab5

<400> 61
atggcgtctc gcggagccac tcgcccaaac ggcccaaaca ctggcaataa aatttgccaa      60
ttcaagttgg tacttctcgg ggaaagtgct gtgggtaagt catctctcgt acttcgcttc     120
gtgaaagggc agtttcacga gttccaagag tctactatcg gagcggcatt cttgacgcag     180
acagtatgtc tggacgacac tactgtaaaa tttgaaatat gggatacagc ggggcaagag     240
aggtatcact ctcttgctcc gatgtattat agaggcgcgc aagcggccat agtcgtatat     300
gatattacca atgaggaatc atttgcacgg gcgaaaaatt gggtaaaaga actgcagcgc     360
caggcgtcac ccaatatagt aattgctttg tctggaaata aggcagattt ggctaacaag     420
cgcgcggtag actttcaaga ggctcaaagc tacgcagacg acaatagttt gctgttcatg     480
gaaacatcag cgaaaactag tatgaatgta aacgaaatct tcatggcaat cgctaagaaa     540
ctcccaaaaa acgagccgca gaaccctggg gccaacagcg caaggggaag aggcgttgac     600
ttgactgagc cgactcaacc aaccagaaac caatgctgtt ccaac                     645

<210> 62
<211> 1281
<212> DNA
<213> Artificial Sequence

<220> 
<223> Rac1-P2A-Rab5a construct

<400> 62
atgcaagcca ttaagtgcgt agtagttggt gatggagccg tcggcaaaac atgcctgctg      60
atctcttata ccacaaacgc attcccgggc gagtacattc ccactgtatt tgacaactac     120
agtgctaacg tcatggtaga tggtaagccg gttaacctcg gactctggga taccgccggc     180
caggaagact atgatagact tagaccgctc agctatccgc aaaccgatgt gttcctgatt     240
tgctttagcc tggtctcccc cgcttcattt gagaatgtga gagcgaagtg gtatccagag     300
gtgcgccatc actgtccgaa cacacccatt atactcgtgg ggactaaact cgacctgagg     360
gatgacaagg acaccatcga aaaactgaaa gaaaagaaac ttacaccaat aacgtaccct     420
cagggtctgg ctatggcaaa agaaattggc gcggtgaaat acctggaatg cagtgcgctc     480
acccagcggg gcttgaagac ggtgttcgat gaggctatac gcgccgtgct gtgtccccca     540
ccagtgaaga aacgaaaacg aaagtgtctt ctccttgcca ccaacttcag cctgctgaag     600
caggccggcg acgtggagga gaaccccggc cccatggcgt ctcgcggagc cactcgccca     660
aacggcccaa acactggcaa taaaatttgc caattcaagt tggtacttct cggggaaagt     720
gctgtgggta agtcatctct cgtacttcgc ttcgtgaaag ggcagtttca cgagttccaa     780
gagtctacta tcggagcggc attcttgacg cagacagtat gtctggacga cactactgta     840
aaatttgaaa tatgggatac agcggggcaa gagaggtatc actctcttgc tccgatgtat     900
tatagaggcg cgcaagcggc catagtcgta tatgatatta ccaatgagga atcatttgca     960
cgggcgaaaa attgggtaaa agaactgcag cgccaggcgt cacccaatat agtaattgct    1020
ttgtctggaa ataaggcaga tttggctaac aagcgcgcgg tagactttca agaggctcaa    1080
agctacgcag acgacaatag tttgctgttc atggaaacat cagcgaaaac tagtatgaat    1140
gtaaacgaaa tcttcatggc aatcgctaag aaactcccaa aaaacgagcc gcagaaccct    1200
ggggccaaca gcgcaagggg aagaggcgtt gacttgactg agccgactca accaaccaga    1260
aaccaatgct gttccaactg a                                              1281

<210> 63
<211> 1455
<212> DNA
<213> Artificial Sequence

<220> 
<223> FA58C2-IgG4-CD28-Syk CER04 chimeric engulfment
      receptor

<400> 63
atgttgctgc tcgttacgtc tctgctcctg tgcgaactgc cgcaccccgc cttcctcctg      60
attccgctga acggctgcgc taatccgctc ggtctgaaaa acaattctat acctgataaa     120
caaatcaccg cctcatcctc ttacaagacg tggggactcc atctcttttc ttggaaccca     180
tcttatgctc gactggacaa acaaggcaat ttcaatgcat gggtcgccgg gagttacggt     240
aacgaccaat ggctccaggt agaccttggt agtagtaagg aggtcacggg tatcatcaca     300
cagggggccc ggaatttcgg ttcagtgcag ttcgttgctt cctacaaggt cgcttattca     360
aacgatagtg ctaattggac agagtaccaa gaccctcgca cgggaagtag taagattttc     420
ccaggcaact gggataacca cagtcacaaa aaaaacttgt tcgagacgcc gatattggcg     480
agatatgtcc ggatacttcc ggtcgcgtgg cataacagaa ttgccctgag gctggaattg     540
ctgggatgcg aaagtaaata tggaccgcca tgccccccat gccccatgtt ttgggtgttg     600
gtcgtagtgg gtggagtcct cgcttgctac tcattgctcg taacggttgc ttttattata     660
ttctgggtta cactcgagga taaagagctc ggatctggta atttcggcac agttaagaaa     720
gggtactacc aaatgaagaa agttgttaag actgtagccg tcaagatact caaaaacgaa     780
gcgaatgatc cggcgctgaa agacgaattg ctcgcggaag cgaacgtgat gcaacagctg     840
gataatccct acattgtcag gatgatagga atatgtgagg ctgaaagctg gatgcttgtt     900
atggagatgg cggagcttgg acccctgaac aaatacctcc agcagaatcg gcatgtgaag     960
gataagaata tcatagaatt ggtccaccag gtttcaatgg gtatgaagta tctggaagaa    1020
agtaacttcg ttcatcggga cttggccgcg cgcaatgtct tgcttgtcac gcaacactac    1080
gccaaaatat ccgacttcgg attgagtaag gccctgcgag cagacgaaaa ttattataag    1140
gctcagacac atggaaaatg gcctgtaaag tggtacgcgc ctgagtgcat caactactac    1200
aagttttcaa gtaaatctga tgtatggagc tttggtgtgc tgatgtggga agctttttct    1260
tatggccaaa aaccgtatag aggaatgaag ggatcagaag tcaccgcaat gctcgaaaaa    1320
ggtgaaagga tggggtgccc cgcgggatgc cctcgagaga tgtatgacct gatgaacctt    1380
tgctggactt atgatgtaga gaatagacct gggttcgcag ccgttgagtt gcgcctcagg    1440
aattactact attga                                                     1455

<210> 64
<211> 783
<212> PRT
<213> Artificial Sequence

<220> 
<223> GMCSF-FMC63-IgG4-CD28-MERTK CER40 chimeric
      engulfment receptor

<220>
<221> SIGNAL         
<222> (1)...(22)
<223> GM-CSF signal peptide

<400> 64
Met Leu Leu Leu Val Thr Ser Leu Leu Leu Cys Glu Leu Pro His Pro
        -20                 -15                 -10
Ala Phe Leu Leu Ile Pro Asp Ile Gln Met Thr Gln Thr Thr Ser Ser
    -5                   1               5                  10
Leu Ser Ala Ser Leu Gly Asp Arg Val Thr Ile Ser Cys Arg Ala Ser
                15                  20                  25
Gln Asp Ile Ser Lys Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Asp Gly
            30                  35                  40
Thr Val Lys Leu Leu Ile Tyr His Thr Ser Arg Leu His Ser Gly Val
        45                  50                  55
Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Tyr Ser Leu Thr
    60                  65                  70
Ile Ser Asn Leu Glu Gln Glu Asp Ile Ala Thr Tyr Phe Cys Gln Gln
75                  80                  85                  90
Gly Asn Thr Leu Pro Tyr Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile
                95                  100                 105
Thr Gly Ser Thr Ser Gly Ser Gly Lys Pro Gly Ser Gly Glu Gly Ser
            110                 115                 120
Thr Lys Gly Glu Val Lys Leu Gln Glu Ser Gly Pro Gly Leu Val Ala
        125                 130                 135
Pro Ser Gln Ser Leu Ser Val Thr Cys Thr Val Ser Gly Val Ser Leu
    140                 145                 150
Pro Asp Tyr Gly Val Ser Trp Ile Arg Gln Pro Pro Arg Lys Gly Leu
155                 160                 165                 170
Glu Trp Leu Gly Val Ile Trp Gly Ser Glu Thr Thr Tyr Tyr Asn Ser
                175                 180                 185
Ala Leu Lys Ser Arg Leu Thr Ile Ile Lys Asp Asn Ser Lys Ser Gln
            190                 195                 200
Val Phe Leu Lys Met Asn Ser Leu Gln Thr Asp Asp Thr Ala Ile Tyr
        205                 210                 215
Tyr Cys Ala Lys His Tyr Tyr Tyr Gly Gly Ser Tyr Ala Met Asp Tyr
    220                 225                 230
Trp Gly Gln Gly Thr Ser Val Thr Val Ser Ser Glu Ser Lys Tyr Gly
235                 240                 245                 250
Pro Pro Cys Pro Pro Cys Pro Met Phe Trp Val Leu Val Val Val Gly
                255                 260                 265
Gly Val Leu Ala Cys Tyr Ser Leu Leu Val Thr Val Ala Phe Ile Ile
            270                 275                 280
Phe Trp Val Ala Leu Arg Arg Arg Val Gln Glu Thr Lys Phe Gly Gly
        285                 290                 295
Ala Phe Ser Glu Glu Asp Ser Gln Leu Val Val Asn Tyr Arg Ala Lys
    300                 305                 310
Lys Ser Phe Cys Arg Arg Ala Ile Glu Leu Thr Leu Gln Ser Leu Gly
315                 320                 325                 330
Val Ser Glu Glu Leu Gln Asn Lys Leu Glu Asp Val Val Ile Asp Arg
                335                 340                 345
Asn Leu Leu Val Leu Gly Lys Val Leu Gly Glu Gly Glu Phe Gly Ser
            350                 355                 360
Val Met Glu Gly Asn Leu Lys Gln Glu Asp Gly Thr Ser Gln Lys Val
        365                 370                 375
Ala Val Lys Thr Met Lys Leu Asp Asn Phe Ser Gln Arg Glu Ile Glu
    380                 385                 390
Glu Phe Leu Ser Glu Ala Ala Cys Met Lys Asp Phe Asn His Pro Asn
395                 400                 405                 410
Val Ile Arg Leu Leu Gly Val Cys Ile Glu Leu Ser Ser Gln Gly Ile
                415                 420                 425
Pro Lys Pro Met Val Ile Leu Pro Phe Met Lys Tyr Gly Asp Leu His
            430                 435                 440
Thr Phe Leu Leu Tyr Ser Arg Leu Asn Thr Gly Pro Lys Tyr Ile His
        445                 450                 455
Leu Gln Thr Leu Leu Lys Phe Met Met Asp Ile Ala Gln Gly Met Glu
    460                 465                 470
Tyr Leu Ser Asn Arg Asn Phe Leu His Arg Asp Leu Ala Ala Arg Asn
475                 480                 485                 490
Cys Met Leu Arg Asp Asp Met Thr Val Cys Val Ala Asp Phe Gly Leu
                495                 500                 505
Ser Lys Lys Ile Tyr Ser Gly Asp Tyr Tyr Arg Gln Gly Arg Ile Ala
            510                 515                 520
Lys Met Pro Val Lys Trp Ile Ala Ile Glu Ser Leu Ala Asp Arg Val
        525                 530                 535
Tyr Thr Ser Lys Ser Asp Val Trp Ala Phe Gly Val Thr Met Trp Glu
    540                 545                 550
Ile Thr Thr Arg Gly Met Thr Pro Tyr Pro Gly Val Gln Asn His Glu
555                 560                 565                 570
Met Tyr Asp Tyr Leu Leu His Gly His Arg Leu Lys Gln Pro Glu Asp
                575                 580                 585
Cys Leu Asp Glu Leu Tyr Asp Ile Met Tyr Ser Cys Trp Ser Ala Asp
            590                 595                 600
Pro Leu Asp Arg Pro Thr Phe Ser Val Leu Arg Leu Gln Leu Glu Lys
        605                 610                 615
Leu Ser Glu Ser Leu Pro Asp Ala Gln Asp Lys Glu Ser Ile Ile Tyr
    620                 625                 630
Ile Asn Thr Gln Leu Leu Glu Ser Cys Glu Gly Ile Ala Asn Gly Pro
635                 640                 645                 650
Ser Leu Thr Gly Leu Asp Met Asn Ile Asp Pro Asp Ser Ile Ile Ala
                655                 660                 665
Ser Cys Thr Pro Gly Ala Ala Val Ser Val Val Thr Ala Glu Val His
            670                 675                 680
Glu Asn Asn Leu Arg Glu Glu Arg Tyr Ile Leu Asn Gly Gly Asn Glu
        685                 690                 695
Glu Trp Glu Asp Val Ser Ser Thr Pro Phe Ala Ala Val Thr Pro Glu
    700                 705                 710
Lys Asp Gly Val Leu Pro Glu Asp Arg Leu Thr Lys Asn Gly Val Ser
715                 720                 725                 730
Trp Ser His His Ser Thr Leu Pro Leu Gly Ser Pro Ser Pro Asp Glu
                735                 740                 745
Leu Leu Phe Val Asp Asp Ser Leu Glu Asp Ser Glu Val Leu Met
            750                 755                 760

<210> 65
<211> 22
<212> PRT
<213> Homo sapiens

<220> 
<223> GM-CSF signal peptide

<400> 65
Met Leu Leu Leu Val Thr Ser Leu Leu Leu Cys Glu Leu Pro His Pro
 1               5                  10                  15
Ala Phe Leu Leu Ile Pro
            20

<210> 66
<211> 245
<212> PRT
<213> Artificial Sequence

<220> 
<223> anti-CD19 FMC63 scFv

<400> 66
Asp Ile Gln Met Thr Gln Thr Thr Ser Ser Leu Ser Ala Ser Leu Gly
 1               5                  10                  15
Asp Arg Val Thr Ile Ser Cys Arg Ala Ser Gln Asp Ile Ser Lys Tyr
            20                  25                  30
Leu Asn Trp Tyr Gln Gln Lys Pro Asp Gly Thr Val Lys Leu Leu Ile
        35                  40                  45
Tyr His Thr Ser Arg Leu His Ser Gly Val Pro Ser Arg Phe Ser Gly
    50                  55                  60
Ser Gly Ser Gly Thr Asp Tyr Ser Leu Thr Ile Ser Asn Leu Glu Gln
65                  70                  75                  80
Glu Asp Ile Ala Thr Tyr Phe Cys Gln Gln Gly Asn Thr Leu Pro Tyr
                85                  90                  95
Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Thr Gly Ser Thr Ser Gly
            100                 105                 110
Ser Gly Lys Pro Gly Ser Gly Glu Gly Ser Thr Lys Gly Glu Val Lys
        115                 120                 125
Leu Gln Glu Ser Gly Pro Gly Leu Val Ala Pro Ser Gln Ser Leu Ser
    130                 135                 140
Val Thr Cys Thr Val Ser Gly Val Ser Leu Pro Asp Tyr Gly Val Ser
145                 150                 155                 160
Trp Ile Arg Gln Pro Pro Arg Lys Gly Leu Glu Trp Leu Gly Val Ile
                165                 170                 175
Trp Gly Ser Glu Thr Thr Tyr Tyr Asn Ser Ala Leu Lys Ser Arg Leu
            180                 185                 190
Thr Ile Ile Lys Asp Asn Ser Lys Ser Gln Val Phe Leu Lys Met Asn
        195                 200                 205
Ser Leu Gln Thr Asp Asp Thr Ala Ile Tyr Tyr Cys Ala Lys His Tyr
    210                 215                 220
Tyr Tyr Gly Gly Ser Tyr Ala Met Asp Tyr Trp Gly Gln Gly Thr Ser
225                 230                 235                 240
Val Thr Val Ser Ser
                245

<210> 67
<211> 12
<212> PRT
<213> Artificial Sequence

<220> 
<223> modified IgG4 hinge region

<400> 67
Glu Ser Lys Tyr Gly Pro Pro Cys Pro Pro Cys Pro
 1               5                  10

<210> 68
<211> 27
<212> PRT
<213> Homo sapiens

<220> 
<223> CD28 transmembrane domain

<400> 68
Phe Trp Val Leu Val Val Val Gly Gly Val Leu Ala Cys Tyr Ser Leu
 1               5                  10                  15
Leu Val Thr Val Ala Phe Ile Ile Phe Trp Val
            20                  25

<210> 69
<211> 473
<212> PRT
<213> Homo sapiens

<220> 
<223> MERTK signaling domain

<400> 69
Lys Arg Val Gln Glu Thr Lys Phe Gly Asn Ala Phe Thr Glu Glu Asp
 1               5                  10                  15
Ser Glu Leu Val Val Asn Tyr Ile Ala Lys Lys Ser Phe Cys Arg Arg
            20                  25                  30
Ala Ile Glu Leu Thr Leu His Ser Leu Gly Val Ser Glu Glu Leu Gln
        35                  40                  45
Asn Lys Leu Glu Asp Val Val Ile Asp Arg Asn Leu Leu Ile Leu Gly
    50                  55                  60
Lys Ile Leu Gly Glu Gly Glu Phe Gly Ser Val Met Glu Gly Asn Leu
65                  70                  75                  80
Lys Gln Glu Asp Gly Thr Ser Leu Lys Val Ala Val Lys Thr Met Lys
                85                  90                  95
Leu Asp Asn Ser Ser Gln Arg Glu Ile Glu Glu Phe Leu Ser Glu Ala
            100                 105                 110
Ala Cys Met Lys Asp Phe Ser His Pro Asn Val Ile Arg Leu Leu Gly
        115                 120                 125
Val Cys Ile Glu Met Ser Ser Gln Gly Ile Pro Lys Pro Met Val Ile
    130                 135                 140
Leu Pro Phe Met Lys Tyr Gly Asp Leu His Thr Tyr Leu Leu Tyr Ser
145                 150                 155                 160
Arg Leu Glu Thr Gly Pro Lys His Ile Pro Leu Gln Thr Leu Leu Lys
                165                 170                 175
Phe Met Val Asp Ile Ala Leu Gly Met Glu Tyr Leu Ser Asn Arg Asn
            180                 185                 190
Phe Leu His Arg Asp Leu Ala Ala Arg Asn Cys Met Leu Arg Asp Asp
        195                 200                 205
Met Thr Val Cys Val Ala Asp Phe Gly Leu Ser Lys Lys Ile Tyr Ser
    210                 215                 220
Gly Asp Tyr Tyr Arg Gln Gly Arg Ile Ala Lys Met Pro Val Lys Trp
225                 230                 235                 240
Ile Ala Ile Glu Ser Leu Ala Asp Arg Val Tyr Thr Ser Lys Ser Asp
                245                 250                 255
Val Trp Ala Phe Gly Val Thr Met Trp Glu Ile Ala Thr Arg Gly Met
            260                 265                 270
Thr Pro Tyr Pro Gly Val Gln Asn His Glu Met Tyr Asp Tyr Leu Leu
        275                 280                 285
His Gly His Arg Leu Lys Gln Pro Glu Asp Cys Leu Asp Glu Leu Tyr
    290                 295                 300
Glu Ile Met Tyr Ser Cys Trp Arg Thr Asp Pro Leu Asp Arg Pro Thr
305                 310                 315                 320
Phe Ser Val Leu Arg Leu Gln Leu Glu Lys Leu Leu Glu Ser Leu Pro
                325                 330                 335
Asp Val Arg Asn Gln Ala Asp Val Ile Tyr Val Asn Thr Gln Leu Leu
            340                 345                 350
Glu Ser Ser Glu Gly Leu Ala Gln Gly Ser Thr Leu Ala Pro Leu Asp
        355                 360                 365
Leu Asn Ile Asp Pro Asp Ser Ile Ile Ala Ser Cys Thr Pro Arg Ala
    370                 375                 380
Ala Ile Ser Val Val Thr Ala Glu Val His Asp Ser Lys Pro His Glu
385                 390                 395                 400
Gly Arg Tyr Ile Leu Asn Gly Gly Ser Glu Glu Trp Glu Asp Leu Thr
                405                 410                 415
Ser Ala Pro Ser Ala Ala Val Thr Ala Glu Lys Asn Ser Val Leu Pro
            420                 425                 430
Gly Glu Arg Leu Val Arg Asn Gly Val Ser Trp Ser His Ser Ser Met
        435                 440                 445
Leu Pro Leu Gly Ser Ser Leu Pro Asp Glu Leu Leu Phe Ala Asp Asp
    450                 455                 460
Ser Ser Glu Gly Ser Glu Val Leu Met
465                 470

<210> 70
<211> 484
<212> PRT
<213> Artificial Sequence

<220> 
<223> GMCSF-FA58C2-IgG4-CD28-SYK CER04 chimeric
      engulfment receptor

<220>
<221> SIGNAL         
<222> (1)...(22)
<223> GM-CSF signal peptide

<400> 70
Met Leu Leu Leu Val Thr Ser Leu Leu Leu Cys Glu Leu Pro His Pro
        -20                 -15                 -10
Ala Phe Leu Leu Ile Pro Leu Asn Gly Cys Ala Asn Pro Leu Gly Leu
    -5                   1               5                  10
Lys Asn Asn Ser Ile Pro Asp Lys Gln Ile Thr Ala Ser Ser Ser Tyr
                15                  20                  25
Lys Thr Trp Gly Leu His Leu Phe Ser Trp Asn Pro Ser Tyr Ala Arg
            30                  35                  40
Leu Asp Lys Gln Gly Asn Phe Asn Ala Trp Val Ala Gly Ser Tyr Gly
        45                  50                  55
Asn Asp Gln Trp Leu Gln Val Asp Leu Gly Ser Ser Lys Glu Val Thr
    60                  65                  70
Gly Ile Ile Thr Gln Gly Ala Arg Asn Phe Gly Ser Val Gln Phe Val
75                  80                  85                  90
Ala Ser Tyr Lys Val Ala Tyr Ser Asn Asp Ser Ala Asn Trp Thr Glu
                95                  100                 105
Tyr Gln Asp Pro Arg Thr Gly Ser Ser Lys Ile Phe Pro Gly Asn Trp
            110                 115                 120
Asp Asn His Ser His Lys Lys Asn Leu Phe Glu Thr Pro Ile Leu Ala
        125                 130                 135
Arg Tyr Val Arg Ile Leu Pro Val Ala Trp His Asn Arg Ile Ala Leu
    140                 145                 150
Arg Leu Glu Leu Leu Gly Cys Glu Ser Lys Tyr Gly Pro Pro Cys Pro
155                 160                 165                 170
Pro Cys Pro Met Phe Trp Val Leu Val Val Val Gly Gly Val Leu Ala
                175                 180                 185
Cys Tyr Ser Leu Leu Val Thr Val Ala Phe Ile Ile Phe Trp Val Thr
            190                 195                 200
Leu Glu Asp Lys Glu Leu Gly Ser Gly Asn Phe Gly Thr Val Lys Lys
        205                 210                 215
Gly Tyr Tyr Gln Met Lys Lys Val Val Lys Thr Val Ala Val Lys Ile
    220                 225                 230
Leu Lys Asn Glu Ala Asn Asp Pro Ala Leu Lys Asp Glu Leu Leu Ala
235                 240                 245                 250
Glu Ala Asn Val Met Gln Gln Leu Asp Asn Pro Tyr Ile Val Arg Met
                255                 260                 265
Ile Gly Ile Cys Glu Ala Glu Ser Trp Met Leu Val Met Glu Met Ala
            270                 275                 280
Glu Leu Gly Pro Leu Asn Lys Tyr Leu Gln Gln Asn Arg His Val Lys
        285                 290                 295
Asp Lys Asn Ile Ile Glu Leu Val His Gln Val Ser Met Gly Met Lys
    300                 305                 310
Tyr Leu Glu Glu Ser Asn Phe Val His Arg Asp Leu Ala Ala Arg Asn
315                 320                 325                 330
Val Leu Leu Val Thr Gln His Tyr Ala Lys Ile Ser Asp Phe Gly Leu
                335                 340                 345
Ser Lys Ala Leu Arg Ala Asp Glu Asn Tyr Tyr Lys Ala Gln Thr His
            350                 355                 360
Gly Lys Trp Pro Val Lys Trp Tyr Ala Pro Glu Cys Ile Asn Tyr Tyr
        365                 370                 375
Lys Phe Ser Ser Lys Ser Asp Val Trp Ser Phe Gly Val Leu Met Trp
    380                 385                 390
Glu Ala Phe Ser Tyr Gly Gln Lys Pro Tyr Arg Gly Met Lys Gly Ser
395                 400                 405                 410
Glu Val Thr Ala Met Leu Glu Lys Gly Glu Arg Met Gly Cys Pro Ala
                415                 420                 425
Gly Cys Pro Arg Glu Met Tyr Asp Leu Met Asn Leu Cys Trp Thr Tyr
            430                 435                 440
Asp Val Glu Asn Arg Pro Gly Phe Ala Ala Val Glu Leu Arg Leu Arg
        445                 450                 455
Asn Tyr Tyr Tyr
    460

<210> 71
<211> 776
<212> PRT
<213> Artificial Sequence

<220> 
<223> Tim4-Tim4-MERTK CER01 mouse chimeric engulfment
      receptor

<220>
<221> SIGNAL         
<222> (1)...(22)

<400> 71
Met Ser Lys Gly Leu Leu Leu Leu Trp Leu Val Thr Glu Leu Trp Trp
        -20                 -15                 -10
Leu Tyr Leu Thr Pro Ala Ala Ser Glu Asp Thr Ile Ile Gly Phe Leu
    -5                   1               5                  10
Gly Gln Pro Val Thr Leu Pro Cys His Tyr Leu Ser Trp Ser Gln Ser
                15                  20                  25
Arg Asn Ser Met Cys Trp Gly Lys Gly Ser Cys Pro Asn Ser Lys Cys
            30                  35                  40
Asn Ala Glu Leu Leu Arg Thr Asp Gly Thr Arg Ile Ile Ser Arg Lys
        45                  50                  55
Ser Thr Lys Tyr Thr Leu Leu Gly Lys Val Gln Phe Gly Glu Val Ser
    60                  65                  70
Leu Thr Ile Ser Asn Thr Asn Arg Gly Asp Ser Gly Val Tyr Cys Cys
75                  80                  85                  90
Arg Ile Glu Val Pro Gly Trp Phe Asn Asp Val Lys Lys Asn Val Arg
                95                  100                 105
Leu Glu Leu Arg Arg Ala Thr Thr Thr Lys Lys Pro Thr Thr Thr Thr
            110                 115                 120
Arg Pro Thr Thr Thr Pro Tyr Val Thr Thr Thr Thr Pro Glu Leu Leu
        125                 130                 135
Pro Thr Thr Val Met Thr Thr Ser Val Leu Pro Thr Thr Thr Pro Pro
    140                 145                 150
Gln Thr Leu Ala Thr Thr Ala Phe Ser Thr Ala Val Thr Thr Cys Pro
155                 160                 165                 170
Ser Thr Thr Pro Gly Ser Phe Ser Gln Glu Thr Thr Lys Gly Ser Ala
                175                 180                 185
Phe Thr Thr Glu Ser Glu Thr Leu Pro Ala Ser Asn His Ser Gln Arg
            190                 195                 200
Ser Met Met Thr Ile Ser Thr Asp Ile Ala Val Leu Arg Pro Thr Gly
        205                 210                 215
Ser Asn Pro Gly Ile Leu Pro Ser Thr Ser Gln Leu Thr Thr Gln Lys
    220                 225                 230
Thr Thr Leu Thr Thr Ser Glu Ser Leu Gln Lys Thr Thr Lys Ser His
235                 240                 245                 250
Gln Ile Asn Ser Arg Gln Thr Ile Leu Ile Ile Ala Cys Cys Val Gly
                255                 260                 265
Phe Val Leu Met Val Leu Leu Phe Leu Ala Phe Leu Ala Leu Arg Arg
            270                 275                 280
Arg Val Gln Glu Thr Lys Phe Gly Gly Ala Phe Ser Glu Glu Asp Ser
        285                 290                 295
Gln Leu Val Val Asn Tyr Arg Ala Lys Lys Ser Phe Cys Arg Arg Ala
    300                 305                 310
Ile Glu Leu Thr Leu Gln Ser Leu Gly Val Ser Glu Glu Leu Gln Asn
315                 320                 325                 330
Lys Leu Glu Asp Val Val Ile Asp Arg Asn Leu Leu Val Leu Gly Lys
                335                 340                 345
Val Leu Gly Glu Gly Glu Phe Gly Ser Val Met Glu Gly Asn Leu Lys
            350                 355                 360
Gln Glu Asp Gly Thr Ser Gln Lys Val Ala Val Lys Thr Met Lys Leu
        365                 370                 375
Asp Asn Phe Ser Gln Arg Glu Ile Glu Glu Phe Leu Ser Glu Ala Ala
    380                 385                 390
Cys Met Lys Asp Phe Asn His Pro Asn Val Ile Arg Leu Leu Gly Val
395                 400                 405                 410
Cys Ile Glu Leu Ser Ser Gln Gly Ile Pro Lys Pro Met Val Ile Leu
                415                 420                 425
Pro Phe Met Lys Tyr Gly Asp Leu His Thr Phe Leu Leu Tyr Ser Arg
            430                 435                 440
Leu Asn Thr Gly Pro Lys Tyr Ile His Leu Gln Thr Leu Leu Lys Phe
        445                 450                 455
Met Met Asp Ile Ala Gln Gly Met Glu Tyr Leu Ser Asn Arg Asn Phe
    460                 465                 470
Leu His Arg Asp Leu Ala Ala Arg Asn Cys Met Leu Arg Asp Asp Met
475                 480                 485                 490
Thr Val Cys Val Ala Asp Phe Gly Leu Ser Lys Lys Ile Tyr Ser Gly
                495                 500                 505
Asp Tyr Tyr Arg Gln Gly Arg Ile Ala Lys Met Pro Val Lys Trp Ile
            510                 515                 520
Ala Ile Glu Ser Leu Ala Asp Arg Val Tyr Thr Ser Lys Ser Asp Val
        525                 530                 535
Trp Ala Phe Gly Val Thr Met Trp Glu Ile Thr Thr Arg Gly Met Thr
    540                 545                 550
Pro Tyr Pro Gly Val Gln Asn His Glu Met Tyr Asp Tyr Leu Leu His
555                 560                 565                 570
Gly His Arg Leu Lys Gln Pro Glu Asp Cys Leu Asp Glu Leu Tyr Asp
                575                 580                 585
Ile Met Tyr Ser Cys Trp Ser Ala Asp Pro Leu Asp Arg Pro Thr Phe
            590                 595                 600
Ser Val Leu Arg Leu Gln Leu Glu Lys Leu Ser Glu Ser Leu Pro Asp
        605                 610                 615
Ala Gln Asp Lys Glu Ser Ile Ile Tyr Ile Asn Thr Gln Leu Leu Glu
    620                 625                 630
Ser Cys Glu Gly Ile Ala Asn Gly Pro Ser Leu Thr Gly Leu Asp Met
635                 640                 645                 650
Asn Ile Asp Pro Asp Ser Ile Ile Ala Ser Cys Thr Pro Gly Ala Ala
                655                 660                 665
Val Ser Val Val Thr Ala Glu Val His Glu Asn Asn Leu Arg Glu Glu
            670                 675                 680
Arg Tyr Ile Leu Asn Gly Gly Asn Glu Glu Trp Glu Asp Val Ser Ser
        685                 690                 695
Thr Pro Phe Ala Ala Val Thr Pro Glu Lys Asp Gly Val Leu Pro Glu
    700                 705                 710
Asp Arg Leu Thr Lys Asn Gly Val Ser Trp Ser His His Ser Thr Leu
715                 720                 725                 730
Pro Leu Gly Ser Pro Ser Pro Asp Glu Leu Leu Phe Val Asp Asp Ser
                735                 740                 745
Leu Glu Asp Ser Glu Val Leu Met
            750

<210> 72
<211> 22
<212> PRT
<213> Mus musculus

<220> 
<223> Tim4 signal peptide

<400> 72
Met Ser Lys Gly Leu Leu Leu Leu Trp Leu Val Thr Glu Leu Trp Trp
 1               5                  10                  15
Leu Tyr Leu Thr Pro Ala
            20

<210> 73
<211> 257
<212> PRT
<213> Mus musculus

<220> 
<223> Tim4 binding domain without signal peptide

<400> 73
Ala Ser Glu Asp Thr Ile Ile Gly Phe Leu Gly Gln Pro Val Thr Leu
 1               5                  10                  15
Pro Cys His Tyr Leu Ser Trp Ser Gln Ser Arg Asn Ser Met Cys Trp
            20                  25                  30
Gly Lys Gly Ser Cys Pro Asn Ser Lys Cys Asn Ala Glu Leu Leu Arg
        35                  40                  45
Thr Asp Gly Thr Arg Ile Ile Ser Arg Lys Ser Thr Lys Tyr Thr Leu
    50                  55                  60
Leu Gly Lys Val Gln Phe Gly Glu Val Ser Leu Thr Ile Ser Asn Thr
65                  70                  75                  80
Asn Arg Gly Asp Ser Gly Val Tyr Cys Cys Arg Ile Glu Val Pro Gly
                85                  90                  95
Trp Phe Asn Asp Val Lys Lys Asn Val Arg Leu Glu Leu Arg Arg Ala
            100                 105                 110
Thr Thr Thr Lys Lys Pro Thr Thr Thr Thr Arg Pro Thr Thr Thr Pro
        115                 120                 125
Tyr Val Thr Thr Thr Thr Pro Glu Leu Leu Pro Thr Thr Val Met Thr
    130                 135                 140
Thr Ser Val Leu Pro Thr Thr Thr Pro Pro Gln Thr Leu Ala Thr Thr
145                 150                 155                 160
Ala Phe Ser Thr Ala Val Thr Thr Cys Pro Ser Thr Thr Pro Gly Ser
                165                 170                 175
Phe Ser Gln Glu Thr Thr Lys Gly Ser Ala Phe Thr Thr Glu Ser Glu
            180                 185                 190
Thr Leu Pro Ala Ser Asn His Ser Gln Arg Ser Met Met Thr Ile Ser
        195                 200                 205
Thr Asp Ile Ala Val Leu Arg Pro Thr Gly Ser Asn Pro Gly Ile Leu
    210                 215                 220
Pro Ser Thr Ser Gln Leu Thr Thr Gln Lys Thr Thr Leu Thr Thr Ser
225                 230                 235                 240
Glu Ser Leu Gln Lys Thr Thr Lys Ser His Gln Ile Asn Ser Arg Gln
                245                 250                 255
Thr


<210> 74
<211> 21
<212> PRT
<213> Mus musculus

<220> 
<223> Tim4 transmembrane domain

<400> 74
Ile Leu Ile Ile Ala Cys Cys Val Gly Phe Val Leu Met Val Leu Leu
 1               5                  10                  15
Phe Leu Ala Phe Leu
            20

<210> 75
<211> 699
<212> PRT
<213> Artificial Sequence

<220> 
<223> GMCSF-FA58C2-IgG4-CD28-MERTK CER03 chimeric
      engulfment receptor

<220>
<221> SIGNAL         
<222> (1)...(22)

<400> 75
Met Leu Leu Leu Val Thr Ser Leu Leu Leu Cys Glu Leu Pro His Pro
        -20                 -15                 -10
Ala Phe Leu Leu Ile Pro Leu Asn Gly Cys Ala Asn Pro Leu Gly Leu
    -5                   1               5                  10
Lys Asn Asn Ser Ile Pro Asp Lys Gln Ile Thr Ala Ser Ser Ser Tyr
                15                  20                  25
Lys Thr Trp Gly Leu His Leu Phe Ser Trp Asn Pro Ser Tyr Ala Arg
            30                  35                  40
Leu Asp Lys Gln Gly Asn Phe Asn Ala Trp Val Ala Gly Ser Tyr Gly
        45                  50                  55
Asn Asp Gln Trp Leu Gln Val Asp Leu Gly Ser Ser Lys Glu Val Thr
    60                  65                  70
Gly Ile Ile Thr Gln Gly Ala Arg Asn Phe Gly Ser Val Gln Phe Val
75                  80                  85                  90
Ala Ser Tyr Lys Val Ala Tyr Ser Asn Asp Ser Ala Asn Trp Thr Glu
                95                  100                 105
Tyr Gln Asp Pro Arg Thr Gly Ser Ser Lys Ile Phe Pro Gly Asn Trp
            110                 115                 120
Asp Asn His Ser His Lys Lys Asn Leu Phe Glu Thr Pro Ile Leu Ala
        125                 130                 135
Arg Tyr Val Arg Ile Leu Pro Val Ala Trp His Asn Arg Ile Ala Leu
    140                 145                 150
Arg Leu Glu Leu Leu Gly Cys Glu Ser Lys Tyr Gly Pro Pro Cys Pro
155                 160                 165                 170
Pro Cys Pro Met Phe Trp Val Leu Val Val Val Gly Gly Val Leu Ala
                175                 180                 185
Cys Tyr Ser Leu Leu Val Thr Val Ala Phe Ile Ile Phe Trp Val Ala
            190                 195                 200
Leu Arg Arg Arg Val Gln Glu Thr Lys Phe Gly Gly Ala Phe Ser Glu
        205                 210                 215
Glu Asp Ser Gln Leu Val Val Asn Tyr Arg Ala Lys Lys Ser Phe Cys
    220                 225                 230
Arg Arg Ala Ile Glu Leu Thr Leu Gln Ser Leu Gly Val Ser Glu Glu
235                 240                 245                 250
Leu Gln Asn Lys Leu Glu Asp Val Val Ile Asp Arg Asn Leu Leu Val
                255                 260                 265
Leu Gly Lys Val Leu Gly Glu Gly Glu Phe Gly Ser Val Met Glu Gly
            270                 275                 280
Asn Leu Lys Gln Glu Asp Gly Thr Ser Gln Lys Val Ala Val Lys Thr
        285                 290                 295
Met Lys Leu Asp Asn Phe Ser Gln Arg Glu Ile Glu Glu Phe Leu Ser
    300                 305                 310
Glu Ala Ala Cys Met Lys Asp Phe Asn His Pro Asn Val Ile Arg Leu
315                 320                 325                 330
Leu Gly Val Cys Ile Glu Leu Ser Ser Gln Gly Ile Pro Lys Pro Met
                335                 340                 345
Val Ile Leu Pro Phe Met Lys Tyr Gly Asp Leu His Thr Phe Leu Leu
            350                 355                 360
Tyr Ser Arg Leu Asn Thr Gly Pro Lys Tyr Ile His Leu Gln Thr Leu
        365                 370                 375
Leu Lys Phe Met Met Asp Ile Ala Gln Gly Met Glu Tyr Leu Ser Asn
    380                 385                 390
Arg Asn Phe Leu His Arg Asp Leu Ala Ala Arg Asn Cys Met Leu Arg
395                 400                 405                 410
Asp Asp Met Thr Val Cys Val Ala Asp Phe Gly Leu Ser Lys Lys Ile
                415                 420                 425
Tyr Ser Gly Asp Tyr Tyr Arg Gln Gly Arg Ile Ala Lys Met Pro Val
            430                 435                 440
Lys Trp Ile Ala Ile Glu Ser Leu Ala Asp Arg Val Tyr Thr Ser Lys
        445                 450                 455
Ser Asp Val Trp Ala Phe Gly Val Thr Met Trp Glu Ile Thr Thr Arg
    460                 465                 470
Gly Met Thr Pro Tyr Pro Gly Val Gln Asn His Glu Met Tyr Asp Tyr
475                 480                 485                 490
Leu Leu His Gly His Arg Leu Lys Gln Pro Glu Asp Cys Leu Asp Glu
                495                 500                 505
Leu Tyr Asp Ile Met Tyr Ser Cys Trp Ser Ala Asp Pro Leu Asp Arg
            510                 515                 520
Pro Thr Phe Ser Val Leu Arg Leu Gln Leu Glu Lys Leu Ser Glu Ser
        525                 530                 535
Leu Pro Asp Ala Gln Asp Lys Glu Ser Ile Ile Tyr Ile Asn Thr Gln
    540                 545                 550
Leu Leu Glu Ser Cys Glu Gly Ile Ala Asn Gly Pro Ser Leu Thr Gly
555                 560                 565                 570
Leu Asp Met Asn Ile Asp Pro Asp Ser Ile Ile Ala Ser Cys Thr Pro
                575                 580                 585
Gly Ala Ala Val Ser Val Val Thr Ala Glu Val His Glu Asn Asn Leu
            590                 595                 600
Arg Glu Glu Arg Tyr Ile Leu Asn Gly Gly Asn Glu Glu Trp Glu Asp
        605                 610                 615
Val Ser Ser Thr Pro Phe Ala Ala Val Thr Pro Glu Lys Asp Gly Val
    620                 625                 630
Leu Pro Glu Asp Arg Leu Thr Lys Asn Gly Val Ser Trp Ser His His
635                 640                 645                 650
Ser Thr Leu Pro Leu Gly Ser Pro Ser Pro Asp Glu Leu Leu Phe Val
                655                 660                 665
Asp Asp Ser Leu Glu Asp Ser Glu Val Leu Met
            670                 675

<210> 76
<211> 192
<212> PRT
<213> Homo sapiens

<220> 
<223> Rac1

<400> 76
Met Gln Ala Ile Lys Cys Val Val Val Gly Asp Gly Ala Val Gly Lys
 1               5                  10                  15
Thr Cys Leu Leu Ile Ser Tyr Thr Thr Asn Ala Phe Pro Gly Glu Tyr
            20                  25                  30
Ile Pro Thr Val Phe Asp Asn Tyr Ser Ala Asn Val Met Val Asp Gly
        35                  40                  45
Lys Pro Val Asn Leu Gly Leu Trp Asp Thr Ala Gly Gln Glu Asp Tyr
    50                  55                  60
Asp Arg Leu Arg Pro Leu Ser Tyr Pro Gln Thr Asp Val Phe Leu Ile
65                  70                  75                  80
Cys Phe Ser Leu Val Ser Pro Ala Ser Phe Glu Asn Val Arg Ala Lys
                85                  90                  95
Trp Tyr Pro Glu Val Arg His His Cys Pro Asn Thr Pro Ile Ile Leu
            100                 105                 110
Val Gly Thr Lys Leu Asp Leu Arg Asp Asp Lys Asp Thr Ile Glu Lys
        115                 120                 125
Leu Lys Glu Lys Lys Leu Thr Pro Ile Thr Tyr Pro Gln Gly Leu Ala
    130                 135                 140
Met Ala Lys Glu Ile Gly Ala Val Lys Tyr Leu Glu Cys Ser Ala Leu
145                 150                 155                 160
Thr Gln Arg Gly Leu Lys Thr Val Phe Asp Glu Ala Ile Arg Ala Val
                165                 170                 175
Leu Cys Pro Pro Pro Val Lys Lys Arg Lys Arg Lys Cys Leu Leu Leu
            180                 185                 190

<210> 77
<211> 215
<212> PRT
<213> Homo sapiens

<220> 
<223> Rab5

<400> 77
Met Ala Ser Arg Gly Ala Thr Arg Pro Asn Gly Pro Asn Thr Gly Asn
 1               5                  10                  15
Lys Ile Cys Gln Phe Lys Leu Val Leu Leu Gly Glu Ser Ala Val Gly
            20                  25                  30
Lys Ser Ser Leu Val Leu Arg Phe Val Lys Gly Gln Phe His Glu Phe
        35                  40                  45
Gln Glu Ser Thr Ile Gly Ala Ala Phe Leu Thr Gln Thr Val Cys Leu
    50                  55                  60
Asp Asp Thr Thr Val Lys Phe Glu Ile Trp Asp Thr Ala Gly Gln Glu
65                  70                  75                  80
Arg Tyr His Ser Leu Ala Pro Met Tyr Tyr Arg Gly Ala Gln Ala Ala
                85                  90                  95
Ile Val Val Tyr Asp Ile Thr Asn Glu Glu Ser Phe Ala Arg Ala Lys
            100                 105                 110
Asn Trp Val Lys Glu Leu Gln Arg Gln Ala Ser Pro Asn Ile Val Ile
        115                 120                 125
Ala Leu Ser Gly Asn Lys Ala Asp Leu Ala Asn Lys Arg Ala Val Asp
    130                 135                 140
Phe Gln Glu Ala Gln Ser Tyr Ala Asp Asp Asn Ser Leu Leu Phe Met
145                 150                 155                 160
Glu Thr Ser Ala Lys Thr Ser Met Asn Val Asn Glu Ile Phe Met Ala
                165                 170                 175
Ile Ala Lys Lys Leu Pro Lys Asn Glu Pro Gln Asn Pro Gly Ala Asn
            180                 185                 190
Ser Ala Arg Gly Arg Gly Val Asp Leu Thr Glu Pro Thr Gln Pro Thr
        195                 200                 205
Arg Asn Gln Cys Cys Ser Asn
    210                 215

<210> 78
<211> 155
<212> PRT
<213> Homo sapiens

<220> 
<223> truncated MyD88 without TIR domain

<400> 78
Met Ala Ala Gly Gly Pro Gly Ala Gly Ser Ala Ala Pro Val Ser Ser
 1               5                  10                  15
Thr Ser Ser Leu Pro Leu Ala Ala Leu Asn Met Arg Val Arg Arg Arg
            20                  25                  30
Leu Ser Leu Phe Leu Asn Val Arg Thr Gln Val Ala Ala Asp Trp Thr
        35                  40                  45
Ala Leu Ala Glu Glu Met Asp Phe Glu Tyr Leu Glu Ile Arg Gln Leu
    50                  55                  60
Glu Thr Gln Ala Asp Pro Thr Gly Arg Leu Leu Asp Ala Trp Gln Gly
65                  70                  75                  80
Arg Pro Gly Ala Ser Val Gly Arg Leu Leu Glu Leu Leu Thr Lys Leu
                85                  90                  95
Gly Arg Asp Asp Val Leu Leu Glu Leu Gly Pro Ser Ile Glu Glu Asp
            100                 105                 110
Cys Gln Lys Tyr Ile Leu Lys Gln Gln Gln Glu Glu Ala Glu Lys Pro
        115                 120                 125
Leu Gln Val Ala Ala Val Asp Ser Ser Val Pro Arg Thr Ala Glu Leu
    130                 135                 140
Ala Gly Ile Thr Thr Leu Asp Asp Pro Leu Gly
145                 150                 155

<210> 79
<211> 455
<212> PRT
<213> Artificial Sequence

<220> 
<223> Tim4-Tim4 TM-tMyD88 CER15 chimeric engulfment
      receptor

<220>
<221> SIGNAL         
<222> (1)...(22)

<400> 79
Met Ser Lys Gly Leu Leu Leu Leu Trp Leu Val Thr Glu Leu Trp Trp
        -20                 -15                 -10
Leu Tyr Leu Thr Pro Ala Ala Ser Glu Asp Thr Ile Ile Gly Phe Leu
    -5                   1               5                  10
Gly Gln Pro Val Thr Leu Pro Cys His Tyr Leu Ser Trp Ser Gln Ser
                15                  20                  25
Arg Asn Ser Met Cys Trp Gly Lys Gly Ser Cys Pro Asn Ser Lys Cys
            30                  35                  40
Asn Ala Glu Leu Leu Arg Thr Asp Gly Thr Arg Ile Ile Ser Arg Lys
        45                  50                  55
Ser Thr Lys Tyr Thr Leu Leu Gly Lys Val Gln Phe Gly Glu Val Ser
    60                  65                  70
Leu Thr Ile Ser Asn Thr Asn Arg Gly Asp Ser Gly Val Tyr Cys Cys
75                  80                  85                  90
Arg Ile Glu Val Pro Gly Trp Phe Asn Asp Val Lys Lys Asn Val Arg
                95                  100                 105
Leu Glu Leu Arg Arg Ala Thr Thr Thr Lys Lys Pro Thr Thr Thr Thr
            110                 115                 120
Arg Pro Thr Thr Thr Pro Tyr Val Thr Thr Thr Thr Pro Glu Leu Leu
        125                 130                 135
Pro Thr Thr Val Met Thr Thr Ser Val Leu Pro Thr Thr Thr Pro Pro
    140                 145                 150
Gln Thr Leu Ala Thr Thr Ala Phe Ser Thr Ala Val Thr Thr Cys Pro
155                 160                 165                 170
Ser Thr Thr Pro Gly Ser Phe Ser Gln Glu Thr Thr Lys Gly Ser Ala
                175                 180                 185
Phe Thr Thr Glu Ser Glu Thr Leu Pro Ala Ser Asn His Ser Gln Arg
            190                 195                 200
Ser Met Met Thr Ile Ser Thr Asp Ile Ala Val Leu Arg Pro Thr Gly
        205                 210                 215
Ser Asn Pro Gly Ile Leu Pro Ser Thr Ser Gln Leu Thr Thr Gln Lys
    220                 225                 230
Thr Thr Leu Thr Thr Ser Glu Ser Leu Gln Lys Thr Thr Lys Ser His
235                 240                 245                 250
Gln Ile Asn Ser Arg Gln Thr Ile Leu Ile Ile Ala Cys Cys Val Gly
                255                 260                 265
Phe Val Leu Met Val Leu Leu Phe Leu Ala Phe Leu Met Ala Ala Gly
            270                 275                 280
Gly Pro Gly Ala Gly Ser Ala Ala Pro Val Ser Ser Thr Ser Ser Leu
        285                 290                 295
Pro Leu Ala Ala Leu Asn Met Arg Val Arg Arg Arg Leu Ser Leu Phe
    300                 305                 310
Leu Asn Val Arg Thr Gln Val Ala Ala Asp Trp Thr Ala Leu Ala Glu
315                 320                 325                 330
Glu Met Asp Phe Glu Tyr Leu Glu Ile Arg Gln Leu Glu Thr Gln Ala
                335                 340                 345
Asp Pro Thr Gly Arg Leu Leu Asp Ala Trp Gln Gly Arg Pro Gly Ala
            350                 355                 360
Ser Val Gly Arg Leu Leu Glu Leu Leu Thr Lys Leu Gly Arg Asp Asp
        365                 370                 375
Val Leu Leu Glu Leu Gly Pro Ser Ile Glu Glu Asp Cys Gln Lys Tyr
    380                 385                 390
Ile Leu Lys Gln Gln Gln Glu Glu Ala Glu Lys Pro Leu Gln Val Ala
395                 400                 405                 410
Ala Val Asp Ser Ser Val Pro Arg Thr Ala Glu Leu Ala Gly Ile Thr
                415                 420                 425
Thr Leu Asp Asp Pro Leu Gly
            430

<210> 80
<211> 596
<212> PRT
<213> Artificial Sequence

<220> 
<223> Tim4-Tim4 TM-MyD88 CER16 chimeric engulfment
      receptor

<220>
<221> SIGNAL         
<222> (1)...(22)

<400> 80
Met Ser Lys Gly Leu Leu Leu Leu Trp Leu Val Thr Glu Leu Trp Trp
        -20                 -15                 -10
Leu Tyr Leu Thr Pro Ala Ala Ser Glu Asp Thr Ile Ile Gly Phe Leu
    -5                   1               5                  10
Gly Gln Pro Val Thr Leu Pro Cys His Tyr Leu Ser Trp Ser Gln Ser
                15                  20                  25
Arg Asn Ser Met Cys Trp Gly Lys Gly Ser Cys Pro Asn Ser Lys Cys
            30                  35                  40
Asn Ala Glu Leu Leu Arg Thr Asp Gly Thr Arg Ile Ile Ser Arg Lys
        45                  50                  55
Ser Thr Lys Tyr Thr Leu Leu Gly Lys Val Gln Phe Gly Glu Val Ser
    60                  65                  70
Leu Thr Ile Ser Asn Thr Asn Arg Gly Asp Ser Gly Val Tyr Cys Cys
75                  80                  85                  90
Arg Ile Glu Val Pro Gly Trp Phe Asn Asp Val Lys Lys Asn Val Arg
                95                  100                 105
Leu Glu Leu Arg Arg Ala Thr Thr Thr Lys Lys Pro Thr Thr Thr Thr
            110                 115                 120
Arg Pro Thr Thr Thr Pro Tyr Val Thr Thr Thr Thr Pro Glu Leu Leu
        125                 130                 135
Pro Thr Thr Val Met Thr Thr Ser Val Leu Pro Thr Thr Thr Pro Pro
    140                 145                 150
Gln Thr Leu Ala Thr Thr Ala Phe Ser Thr Ala Val Thr Thr Cys Pro
155                 160                 165                 170
Ser Thr Thr Pro Gly Ser Phe Ser Gln Glu Thr Thr Lys Gly Ser Ala
                175                 180                 185
Phe Thr Thr Glu Ser Glu Thr Leu Pro Ala Ser Asn His Ser Gln Arg
            190                 195                 200
Ser Met Met Thr Ile Ser Thr Asp Ile Ala Val Leu Arg Pro Thr Gly
        205                 210                 215
Ser Asn Pro Gly Ile Leu Pro Ser Thr Ser Gln Leu Thr Thr Gln Lys
    220                 225                 230
Thr Thr Leu Thr Thr Ser Glu Ser Leu Gln Lys Thr Thr Lys Ser His
235                 240                 245                 250
Gln Ile Asn Ser Arg Gln Thr Ile Leu Ile Ile Ala Cys Cys Val Gly
                255                 260                 265
Phe Val Leu Met Val Leu Leu Phe Leu Ala Phe Leu Met Ala Ala Gly
            270                 275                 280
Gly Pro Gly Ala Gly Ser Ala Ala Pro Val Ser Ser Thr Ser Ser Leu
        285                 290                 295
Pro Leu Ala Ala Leu Asn Met Arg Val Arg Arg Arg Leu Ser Leu Phe
    300                 305                 310
Leu Asn Val Arg Thr Gln Val Ala Ala Asp Trp Thr Ala Leu Ala Glu
315                 320                 325                 330
Glu Met Asp Phe Glu Tyr Leu Glu Ile Arg Gln Leu Glu Thr Gln Ala
                335                 340                 345
Asp Pro Thr Gly Arg Leu Leu Asp Ala Trp Gln Gly Arg Pro Gly Ala
            350                 355                 360
Ser Val Gly Arg Leu Leu Glu Leu Leu Thr Lys Leu Gly Arg Asp Asp
        365                 370                 375
Val Leu Leu Glu Leu Gly Pro Ser Ile Glu Glu Asp Cys Gln Lys Tyr
    380                 385                 390
Ile Leu Lys Gln Gln Gln Glu Glu Ala Glu Lys Pro Leu Gln Val Ala
395                 400                 405                 410
Ala Val Asp Ser Ser Val Pro Arg Thr Ala Glu Leu Ala Gly Ile Thr
                415                 420                 425
Thr Leu Asp Asp Pro Leu Gly His Met Pro Glu Arg Phe Asp Ala Phe
            430                 435                 440
Ile Cys Tyr Cys Pro Ser Asp Ile Gln Phe Val Gln Glu Met Ile Arg
        445                 450                 455
Gln Leu Glu Gln Thr Asn Tyr Arg Leu Lys Leu Cys Val Ser Asp Arg
    460                 465                 470
Asp Val Leu Pro Gly Thr Cys Val Trp Ser Ile Ala Ser Glu Leu Ile
475                 480                 485                 490
Glu Lys Arg Cys Arg Arg Met Val Val Val Val Ser Asp Asp Tyr Leu
                495                 500                 505
Gln Ser Lys Glu Cys Asp Phe Gln Thr Lys Phe Ala Leu Ser Leu Ser
            510                 515                 520
Pro Gly Ala His Gln Lys Arg Leu Ile Pro Ile Lys Tyr Lys Ala Met
        525                 530                 535
Lys Lys Glu Phe Pro Ser Ile Leu Arg Phe Ile Thr Val Cys Asp Tyr
    540                 545                 550
Thr Asn Pro Cys Thr Lys Ser Trp Phe Trp Thr Arg Leu Ala Lys Ala
555                 560                 565                 570
Leu Ser Leu Pro


<210> 81
<211> 21
<212> PRT
<213> Homo sapiens

<220> 
<221> PEPTIDE        
<222> (0)...(0)
<223> DAP12 transmembrane domain

<400> 81
Gly Val Leu Ala Gly Ile Val Met Gly Asp Leu Val Leu Thr Val Leu
 1               5                  10                  15
Ile Ala Leu Ala Val
            20

<210> 82
<211> 52
<212> PRT
<213> Homo sapiens

<220> 
<223> DAP12 signaling domain

<400> 82
Tyr Phe Leu Gly Arg Leu Val Pro Arg Gly Arg Gly Ala Ala Glu Ala
 1               5                  10                  15
Ala Thr Arg Lys Gln Arg Ile Thr Glu Thr Glu Ser Pro Tyr Gln Glu
            20                  25                  30
Leu Gln Gly Gln Arg Ser Asp Val Tyr Ser Asp Leu Asn Thr Gln Arg
        35                  40                  45
Pro Tyr Tyr Lys
    50

<210> 83
<211> 740
<212> PRT
<213> Artificial Sequence

<220> 
<223> Tim4-Tim4 TM-Tyro3 CER08 chimeric engulfment
      receptor

<220>
<221> SIGNAL         
<222> (1)...(22)
<223> Tim4 signal peptide

<400> 83
Met Ser Lys Gly Leu Leu Leu Leu Trp Leu Val Thr Glu Leu Trp Trp
        -20                 -15                 -10
Leu Tyr Leu Thr Pro Ala Ala Ser Glu Asp Thr Ile Ile Gly Phe Leu
    -5                   1               5                  10
Gly Gln Pro Val Thr Leu Pro Cys His Tyr Leu Ser Trp Ser Gln Ser
                15                  20                  25
Arg Asn Ser Met Cys Trp Gly Lys Gly Ser Cys Pro Asn Ser Lys Cys
            30                  35                  40
Asn Ala Glu Leu Leu Arg Thr Asp Gly Thr Arg Ile Ile Ser Arg Lys
        45                  50                  55
Ser Thr Lys Tyr Thr Leu Leu Gly Lys Val Gln Phe Gly Glu Val Ser
    60                  65                  70
Leu Thr Ile Ser Asn Thr Asn Arg Gly Asp Ser Gly Val Tyr Cys Cys
75                  80                  85                  90
Arg Ile Glu Val Pro Gly Trp Phe Asn Asp Val Lys Lys Asn Val Arg
                95                  100                 105
Leu Glu Leu Arg Arg Ala Thr Thr Thr Lys Lys Pro Thr Thr Thr Thr
            110                 115                 120
Arg Pro Thr Thr Thr Pro Tyr Val Thr Thr Thr Thr Pro Glu Leu Leu
        125                 130                 135
Pro Thr Thr Val Met Thr Thr Ser Val Leu Pro Thr Thr Thr Pro Pro
    140                 145                 150
Gln Thr Leu Ala Thr Thr Ala Phe Ser Thr Ala Val Thr Thr Cys Pro
155                 160                 165                 170
Ser Thr Thr Pro Gly Ser Phe Ser Gln Glu Thr Thr Lys Gly Ser Ala
                175                 180                 185
Phe Thr Thr Glu Ser Glu Thr Leu Pro Ala Ser Asn His Ser Gln Arg
            190                 195                 200
Ser Met Met Thr Ile Ser Thr Asp Ile Ala Val Leu Arg Pro Thr Gly
        205                 210                 215
Ser Asn Pro Gly Ile Leu Pro Ser Thr Ser Gln Leu Thr Thr Gln Lys
    220                 225                 230
Thr Thr Leu Thr Thr Ser Glu Ser Leu Gln Lys Thr Thr Lys Ser His
235                 240                 245                 250
Gln Ile Asn Ser Arg Gln Thr Ile Leu Ile Ile Ala Cys Cys Val Gly
                255                 260                 265
Phe Val Leu Met Val Leu Leu Phe Leu Ala Phe Leu Leu Arg Lys Arg
            270                 275                 280
Arg Lys Glu Thr Arg Phe Gly Gln Ala Phe Asp Ser Val Met Ala Arg
        285                 290                 295
Gly Glu Pro Ala Val His Phe Arg Ala Ala Arg Ser Phe Asn Arg Glu
    300                 305                 310
Arg Pro Glu Arg Ile Glu Ala Thr Leu Asp Ser Leu Gly Ile Ser Asp
315                 320                 325                 330
Glu Leu Lys Glu Lys Leu Glu Asp Val Leu Ile Pro Glu Gln Gln Phe
                335                 340                 345
Thr Leu Gly Arg Met Leu Gly Lys Gly Glu Phe Gly Ser Val Arg Glu
            350                 355                 360
Ala Gln Leu Lys Gln Glu Asp Gly Ser Phe Val Lys Val Ala Val Lys
        365                 370                 375
Met Leu Lys Ala Asp Ile Ile Ala Ser Ser Asp Ile Glu Glu Phe Leu
    380                 385                 390
Arg Glu Ala Ala Cys Met Lys Glu Phe Asp His Pro His Val Ala Lys
395                 400                 405                 410
Leu Val Gly Val Ser Leu Arg Ser Arg Ala Lys Gly Arg Leu Pro Ile
                415                 420                 425
Pro Met Val Ile Leu Pro Phe Met Lys His Gly Asp Leu His Ala Phe
            430                 435                 440
Leu Leu Ala Ser Arg Ile Gly Glu Asn Pro Phe Asn Leu Pro Leu Gln
        445                 450                 455
Thr Leu Ile Arg Phe Met Val Asp Ile Ala Cys Gly Met Glu Tyr Leu
    460                 465                 470
Ser Ser Arg Asn Phe Ile His Arg Asp Leu Ala Ala Arg Asn Cys Met
475                 480                 485                 490
Leu Ala Glu Asp Met Thr Val Cys Val Ala Asp Phe Gly Leu Ser Arg
                495                 500                 505
Lys Ile Tyr Ser Gly Asp Tyr Tyr Arg Gln Gly Cys Ala Ser Lys Leu
            510                 515                 520
Pro Val Lys Trp Leu Ala Leu Glu Ser Leu Ala Asp Asn Leu Tyr Thr
        525                 530                 535
Val Gln Ser Asp Val Trp Ala Phe Gly Val Thr Met Trp Glu Ile Met
    540                 545                 550
Thr Arg Gly Gln Thr Pro Tyr Ala Gly Ile Glu Asn Ala Glu Ile Tyr
555                 560                 565                 570
Asn Tyr Leu Ile Gly Gly Asn Arg Leu Lys Gln Pro Pro Glu Cys Met
                575                 580                 585
Glu Asp Val Tyr Asp Leu Met Tyr Gln Cys Trp Ser Ala Asp Pro Lys
            590                 595                 600
Gln Arg Pro Ser Phe Thr Cys Leu Arg Met Glu Leu Glu Asn Ile Leu
        605                 610                 615
Gly Gln Leu Ser Val Leu Ser Ala Ser Gln Asp Pro Leu Tyr Ile Asn
    620                 625                 630
Ile Glu Arg Ala Glu Glu Pro Thr Ala Gly Gly Ser Leu Glu Leu Pro
635                 640                 645                 650
Gly Arg Asp Gln Pro Tyr Ser Gly Ala Gly Asp Gly Ser Gly Met Gly
                655                 660                 665
Ala Val Gly Gly Thr Pro Ser Asp Cys Arg Tyr Ile Leu Thr Pro Gly
            670                 675                 680
Gly Leu Ala Glu Gln Pro Gly Gln Ala Glu His Gln Pro Glu Ser Pro
        685                 690                 695
Leu Asn Glu Thr Gln Arg Leu Leu Leu Leu Gln Gln Gly Leu Leu Pro
    700                 705                 710
His Ser Ser Cys
715

<210> 84
<211> 352
<212> PRT
<213> Artificial Sequence

<220> 
<223> Tim4-Tim4 TM-DAP12 CER09 chimeric engulfment
      receptor

<220>
<221> SIGNAL         
<222> (1)...(22)
<223> Tim4 signal peptide

<400> 84
Met Ser Lys Gly Leu Leu Leu Leu Trp Leu Val Thr Glu Leu Trp Trp
        -20                 -15                 -10
Leu Tyr Leu Thr Pro Ala Ala Ser Glu Asp Thr Ile Ile Gly Phe Leu
    -5                   1               5                  10
Gly Gln Pro Val Thr Leu Pro Cys His Tyr Leu Ser Trp Ser Gln Ser
                15                  20                  25
Arg Asn Ser Met Cys Trp Gly Lys Gly Ser Cys Pro Asn Ser Lys Cys
            30                  35                  40
Asn Ala Glu Leu Leu Arg Thr Asp Gly Thr Arg Ile Ile Ser Arg Lys
        45                  50                  55
Ser Thr Lys Tyr Thr Leu Leu Gly Lys Val Gln Phe Gly Glu Val Ser
    60                  65                  70
Leu Thr Ile Ser Asn Thr Asn Arg Gly Asp Ser Gly Val Tyr Cys Cys
75                  80                  85                  90
Arg Ile Glu Val Pro Gly Trp Phe Asn Asp Val Lys Lys Asn Val Arg
                95                  100                 105
Leu Glu Leu Arg Arg Ala Thr Thr Thr Lys Lys Pro Thr Thr Thr Thr
            110                 115                 120
Arg Pro Thr Thr Thr Pro Tyr Val Thr Thr Thr Thr Pro Glu Leu Leu
        125                 130                 135
Pro Thr Thr Val Met Thr Thr Ser Val Leu Pro Thr Thr Thr Pro Pro
    140                 145                 150
Gln Thr Leu Ala Thr Thr Ala Phe Ser Thr Ala Val Thr Thr Cys Pro
155                 160                 165                 170
Ser Thr Thr Pro Gly Ser Phe Ser Gln Glu Thr Thr Lys Gly Ser Ala
                175                 180                 185
Phe Thr Thr Glu Ser Glu Thr Leu Pro Ala Ser Asn His Ser Gln Arg
            190                 195                 200
Ser Met Met Thr Ile Ser Thr Asp Ile Ala Val Leu Arg Pro Thr Gly
        205                 210                 215
Ser Asn Pro Gly Ile Leu Pro Ser Thr Ser Gln Leu Thr Thr Gln Lys
    220                 225                 230
Thr Thr Leu Thr Thr Ser Glu Ser Leu Gln Lys Thr Thr Lys Ser His
235                 240                 245                 250
Gln Ile Asn Ser Arg Gln Thr Ile Leu Ile Ile Ala Cys Cys Val Gly
                255                 260                 265
Phe Val Leu Met Val Leu Leu Phe Leu Ala Phe Leu Tyr Phe Leu Gly
            270                 275                 280
Arg Leu Val Pro Arg Gly Arg Gly Ala Ala Glu Ala Ala Thr Arg Lys
        285                 290                 295
Gln Arg Ile Thr Glu Thr Glu Ser Pro Tyr Gln Glu Leu Gln Gly Gln
    300                 305                 310
Arg Ser Asp Val Tyr Ser Asp Leu Asn Thr Gln Arg Pro Tyr Tyr Lys
315                 320                 325                 330

<210> 85
<211> 63
<212> DNA
<213> Homo sapiens

<220> 
<223> FcepsilonRIgamma transmembrane domain

<400> 85
ctttgttaca ttctcgacgc gatattgttc ctttatggaa tagttttgac gctcctttat      60
tgc                                                                    63

<210> 86
<211> 352
<212> PRT
<213> Artificial Sequence

<220> 
<223> Tim4-DAP12-DAP12 CER10 chimeric engulfment
      receptor

<220>
<221> SIGNAL         
<222> (1)...(22)
<223> Tim4 signal peptide

<400> 86
Met Ser Lys Gly Leu Leu Leu Leu Trp Leu Val Thr Glu Leu Trp Trp
        -20                 -15                 -10
Leu Tyr Leu Thr Pro Ala Ala Ser Glu Asp Thr Ile Ile Gly Phe Leu
    -5                   1               5                  10
Gly Gln Pro Val Thr Leu Pro Cys His Tyr Leu Ser Trp Ser Gln Ser
                15                  20                  25
Arg Asn Ser Met Cys Trp Gly Lys Gly Ser Cys Pro Asn Ser Lys Cys
            30                  35                  40
Asn Ala Glu Leu Leu Arg Thr Asp Gly Thr Arg Ile Ile Ser Arg Lys
        45                  50                  55
Ser Thr Lys Tyr Thr Leu Leu Gly Lys Val Gln Phe Gly Glu Val Ser
    60                  65                  70
Leu Thr Ile Ser Asn Thr Asn Arg Gly Asp Ser Gly Val Tyr Cys Cys
75                  80                  85                  90
Arg Ile Glu Val Pro Gly Trp Phe Asn Asp Val Lys Lys Asn Val Arg
                95                  100                 105
Leu Glu Leu Arg Arg Ala Thr Thr Thr Lys Lys Pro Thr Thr Thr Thr
            110                 115                 120
Arg Pro Thr Thr Thr Pro Tyr Val Thr Thr Thr Thr Pro Glu Leu Leu
        125                 130                 135
Pro Thr Thr Val Met Thr Thr Ser Val Leu Pro Thr Thr Thr Pro Pro
    140                 145                 150
Gln Thr Leu Ala Thr Thr Ala Phe Ser Thr Ala Val Thr Thr Cys Pro
155                 160                 165                 170
Ser Thr Thr Pro Gly Ser Phe Ser Gln Glu Thr Thr Lys Gly Ser Ala
                175                 180                 185
Phe Thr Thr Glu Ser Glu Thr Leu Pro Ala Ser Asn His Ser Gln Arg
            190                 195                 200
Ser Met Met Thr Ile Ser Thr Asp Ile Ala Val Leu Arg Pro Thr Gly
        205                 210                 215
Ser Asn Pro Gly Ile Leu Pro Ser Thr Ser Gln Leu Thr Thr Gln Lys
    220                 225                 230
Thr Thr Leu Thr Thr Ser Glu Ser Leu Gln Lys Thr Thr Lys Ser His
235                 240                 245                 250
Gln Ile Asn Ser Arg Gln Thr Gly Val Leu Ala Gly Ile Val Met Gly
                255                 260                 265
Asp Leu Val Leu Thr Val Leu Ile Ala Leu Ala Val Tyr Phe Leu Gly
            270                 275                 280
Arg Leu Val Pro Arg Gly Arg Gly Ala Ala Glu Ala Ala Thr Arg Lys
        285                 290                 295
Gln Arg Ile Thr Glu Thr Glu Ser Pro Tyr Gln Glu Leu Gln Gly Gln
    300                 305                 310
Arg Ser Asp Val Tyr Ser Asp Leu Asn Thr Gln Arg Pro Tyr Tyr Lys
315                 320                 325                 330

<210> 87
<211> 722
<212> PRT
<213> Artificial Sequence

<220> 
<223> Tim4-Tim4-Axl CER11 chimeric engulfment receptor

<220>
<221> SIGNAL         
<222> (1)...(22)
<223> Tim4 signal peptide

<400> 87
Met Ser Lys Gly Leu Leu Leu Leu Trp Leu Val Thr Glu Leu Trp Trp
        -20                 -15                 -10
Leu Tyr Leu Thr Pro Ala Ala Ser Glu Asp Thr Ile Ile Gly Phe Leu
    -5                   1               5                  10
Gly Gln Pro Val Thr Leu Pro Cys His Tyr Leu Ser Trp Ser Gln Ser
                15                  20                  25
Arg Asn Ser Met Cys Trp Gly Lys Gly Ser Cys Pro Asn Ser Lys Cys
            30                  35                  40
Asn Ala Glu Leu Leu Arg Thr Asp Gly Thr Arg Ile Ile Ser Arg Lys
        45                  50                  55
Ser Thr Lys Tyr Thr Leu Leu Gly Lys Val Gln Phe Gly Glu Val Ser
    60                  65                  70
Leu Thr Ile Ser Asn Thr Asn Arg Gly Asp Ser Gly Val Tyr Cys Cys
75                  80                  85                  90
Arg Ile Glu Val Pro Gly Trp Phe Asn Asp Val Lys Lys Asn Val Arg
                95                  100                 105
Leu Glu Leu Arg Arg Ala Thr Thr Thr Lys Lys Pro Thr Thr Thr Thr
            110                 115                 120
Arg Pro Thr Thr Thr Pro Tyr Val Thr Thr Thr Thr Pro Glu Leu Leu
        125                 130                 135
Pro Thr Thr Val Met Thr Thr Ser Val Leu Pro Thr Thr Thr Pro Pro
    140                 145                 150
Gln Thr Leu Ala Thr Thr Ala Phe Ser Thr Ala Val Thr Thr Cys Pro
155                 160                 165                 170
Ser Thr Thr Pro Gly Ser Phe Ser Gln Glu Thr Thr Lys Gly Ser Ala
                175                 180                 185
Phe Thr Thr Glu Ser Glu Thr Leu Pro Ala Ser Asn His Ser Gln Arg
            190                 195                 200
Ser Met Met Thr Ile Ser Thr Asp Ile Ala Val Leu Arg Pro Thr Gly
        205                 210                 215
Ser Asn Pro Gly Ile Leu Pro Ser Thr Ser Gln Leu Thr Thr Gln Lys
    220                 225                 230
Thr Thr Leu Thr Thr Ser Glu Ser Leu Gln Lys Thr Thr Lys Ser His
235                 240                 245                 250
Gln Ile Asn Ser Arg Gln Thr Ile Leu Ile Ile Ala Cys Cys Val Gly
                255                 260                 265
Phe Val Leu Met Val Leu Leu Phe Leu Ala Phe Leu His Arg Arg Lys
            270                 275                 280
Lys Glu Thr Arg Tyr Gly Glu Val Phe Glu Pro Thr Val Glu Arg Gly
        285                 290                 295
Glu Leu Val Val Arg Tyr Arg Val Arg Lys Ser Tyr Ser Arg Arg Thr
    300                 305                 310
Thr Glu Ala Thr Leu Asn Ser Leu Gly Ile Ser Glu Glu Leu Lys Glu
315                 320                 325                 330
Lys Leu Arg Asp Val Met Val Asp Arg His Lys Val Ala Leu Gly Lys
                335                 340                 345
Thr Leu Gly Glu Gly Glu Phe Gly Ala Val Met Glu Gly Gln Leu Asn
            350                 355                 360
Gln Asp Asp Ser Ile Leu Lys Val Ala Val Lys Thr Met Lys Ile Ala
        365                 370                 375
Ile Cys Thr Arg Ser Glu Leu Glu Asp Phe Leu Ser Glu Ala Val Cys
    380                 385                 390
Met Lys Glu Phe Asp His Pro Asn Val Met Arg Leu Ile Gly Val Cys
395                 400                 405                 410
Phe Gln Gly Ser Glu Arg Glu Ser Phe Pro Ala Pro Val Val Ile Leu
                415                 420                 425
Pro Phe Met Lys His Gly Asp Leu His Ser Phe Leu Leu Tyr Ser Arg
            430                 435                 440
Leu Gly Asp Gln Pro Val Tyr Leu Pro Thr Gln Met Leu Val Lys Phe
        445                 450                 455
Met Ala Asp Ile Ala Ser Gly Met Glu Tyr Leu Ser Thr Lys Arg Phe
    460                 465                 470
Ile His Arg Asp Leu Ala Ala Arg Asn Cys Met Leu Asn Glu Asn Met
475                 480                 485                 490
Ser Val Cys Val Ala Asp Phe Gly Leu Ser Lys Lys Ile Tyr Asn Gly
                495                 500                 505
Asp Tyr Tyr Arg Gln Gly Arg Ile Ala Lys Met Pro Val Lys Trp Ile
            510                 515                 520
Ala Ile Glu Ser Leu Ala Asp Arg Val Tyr Thr Ser Lys Ser Asp Val
        525                 530                 535
Trp Ser Phe Gly Val Thr Met Trp Glu Ile Ala Thr Arg Gly Gln Thr
    540                 545                 550
Pro Tyr Pro Gly Val Glu Asn Ser Glu Ile Tyr Asp Tyr Leu Arg Gln
555                 560                 565                 570
Gly Asn Arg Leu Lys Gln Pro Ala Asp Cys Leu Asp Gly Leu Tyr Ala
                575                 580                 585
Leu Met Ser Arg Cys Trp Glu Leu Asn Pro Gln Asp Arg Pro Ser Phe
            590                 595                 600
Thr Glu Leu Arg Glu Asp Leu Glu Asn Thr Leu Lys Ala Leu Pro Pro
        605                 610                 615
Ala Gln Glu Pro Asp Glu Ile Leu Tyr Val Asn Met Asp Glu Gly Gly
    620                 625                 630
Gly Tyr Pro Glu Pro Pro Gly Ala Ala Gly Gly Ala Asp Pro Pro Thr
635                 640                 645                 650
Gln Pro Asp Pro Lys Asp Ser Cys Ser Cys Leu Thr Ala Ala Glu Val
                655                 660                 665
His Pro Ala Gly Arg Tyr Val Leu Cys Pro Ser Thr Thr Pro Ser Pro
            670                 675                 680
Ala Gln Pro Ala Asp Arg Gly Ser Pro Ala Ala Pro Gly Gln Glu Asp
        685                 690                 695
Gly Ala
    700

<210> 88
<211> 42
<212> PRT
<213> Homo sapiens

<220> 
<223> FcepsilonRIgamma signaling domain

<400> 88
Arg Leu Lys Ile Gln Val Arg Lys Ala Ala Ile Thr Ser Tyr Glu Lys
 1               5                  10                  15
Ser Asp Gly Val Tyr Thr Gly Leu Ser Thr Arg Asn Gln Glu Thr Tyr
            20                  25                  30
Glu Thr Leu Lys His Glu Lys Pro Pro Gln
        35                  40

<210> 89
<211> 21
<212> PRT
<213> Homo sapiens

<220> 
<223> FcepsilonRIgamma transmembrane domain

<400> 89
Leu Cys Tyr Ile Leu Asp Ala Ile Leu Phe Leu Tyr Gly Ile Val Leu
 1               5                  10                  15
Thr Leu Leu Tyr Cys
            20

<210> 90
<211> 342
<212> PRT
<213> Artificial Sequence

<220> 
<223> Tim4-Tim4- FcepsilonRIgamma CER12 chimeric engulfment receptor

<220>
<221> SIGNAL         
<222> (1)...(22)

<400> 90
Met Ser Lys Gly Leu Leu Leu Leu Trp Leu Val Thr Glu Leu Trp Trp
 1               5                  10                  15
Leu Tyr Leu Thr Pro Ala Ala Ser Glu Asp Thr Ile Ile Gly Phe Leu
            20                  25                  30
Gly Gln Pro Val Thr Leu Pro Cys His Tyr Leu Ser Trp Ser Gln Ser
        35                  40                  45
Arg Asn Ser Met Cys Trp Gly Lys Gly Ser Cys Pro Asn Ser Lys Cys
    50                  55                  60
Asn Ala Glu Leu Leu Arg Thr Asp Gly Thr Arg Ile Ile Ser Arg Lys
65                  70                  75                  80
Ser Thr Lys Tyr Thr Leu Leu Gly Lys Val Gln Phe Gly Glu Val Ser
                85                  90                  95
Leu Thr Ile Ser Asn Thr Asn Arg Gly Asp Ser Gly Val Tyr Cys Cys
            100                 105                 110
Arg Ile Glu Val Pro Gly Trp Phe Asn Asp Val Lys Lys Asn Val Arg
        115                 120                 125
Leu Glu Leu Arg Arg Ala Thr Thr Thr Lys Lys Pro Thr Thr Thr Thr
    130                 135                 140
Arg Pro Thr Thr Thr Pro Tyr Val Thr Thr Thr Thr Pro Glu Leu Leu
145                 150                 155                 160
Pro Thr Thr Val Met Thr Thr Ser Val Leu Pro Thr Thr Thr Pro Pro
                165                 170                 175
Gln Thr Leu Ala Thr Thr Ala Phe Ser Thr Ala Val Thr Thr Cys Pro
            180                 185                 190
Ser Thr Thr Pro Gly Ser Phe Ser Gln Glu Thr Thr Lys Gly Ser Ala
        195                 200                 205
Phe Thr Thr Glu Ser Glu Thr Leu Pro Ala Ser Asn His Ser Gln Arg
    210                 215                 220
Ser Met Met Thr Ile Ser Thr Asp Ile Ala Val Leu Arg Pro Thr Gly
225                 230                 235                 240
Ser Asn Pro Gly Ile Leu Pro Ser Thr Ser Gln Leu Thr Thr Gln Lys
                245                 250                 255
Thr Thr Leu Thr Thr Ser Glu Ser Leu Gln Lys Thr Thr Lys Ser His
            260                 265                 270
Gln Ile Asn Ser Arg Gln Thr Ile Leu Ile Ile Ala Cys Cys Val Gly
        275                 280                 285
Phe Val Leu Met Val Leu Leu Phe Leu Ala Phe Leu Arg Leu Lys Ile
    290                 295                 300
Gln Val Arg Lys Ala Ala Ile Thr Ser Tyr Glu Lys Ser Asp Gly Val
305                 310                 315                 320
Tyr Thr Gly Leu Ser Thr Arg Asn Gln Glu Thr Tyr Glu Thr Leu Lys
                325                 330                 335
His Glu Lys Pro Pro Gln
            340

<210> 91
<211> 342
<212> PRT
<213> Artificial Sequence

<220> 
<223> Tim4- Fc(epsilon)RI(gamma)-Fc(epsilon)RI(gamma) CER13 chimeric engulfment
      receptor

<220>
<221> SIGNAL         
<222> (1)...(22)

<400> 91
Met Ser Lys Gly Leu Leu Leu Leu Trp Leu Val Thr Glu Leu Trp Trp
        -20                 -15                 -10
Leu Tyr Leu Thr Pro Ala Ala Ser Glu Asp Thr Ile Ile Gly Phe Leu
    -5                   1               5                  10
Gly Gln Pro Val Thr Leu Pro Cys His Tyr Leu Ser Trp Ser Gln Ser
                15                  20                  25
Arg Asn Ser Met Cys Trp Gly Lys Gly Ser Cys Pro Asn Ser Lys Cys
            30                  35                  40
Asn Ala Glu Leu Leu Arg Thr Asp Gly Thr Arg Ile Ile Ser Arg Lys
        45                  50                  55
Ser Thr Lys Tyr Thr Leu Leu Gly Lys Val Gln Phe Gly Glu Val Ser
    60                  65                  70
Leu Thr Ile Ser Asn Thr Asn Arg Gly Asp Ser Gly Val Tyr Cys Cys
75                  80                  85                  90
Arg Ile Glu Val Pro Gly Trp Phe Asn Asp Val Lys Lys Asn Val Arg
                95                  100                 105
Leu Glu Leu Arg Arg Ala Thr Thr Thr Lys Lys Pro Thr Thr Thr Thr
            110                 115                 120
Arg Pro Thr Thr Thr Pro Tyr Val Thr Thr Thr Thr Pro Glu Leu Leu
        125                 130                 135
Pro Thr Thr Val Met Thr Thr Ser Val Leu Pro Thr Thr Thr Pro Pro
    140                 145                 150
Gln Thr Leu Ala Thr Thr Ala Phe Ser Thr Ala Val Thr Thr Cys Pro
155                 160                 165                 170
Ser Thr Thr Pro Gly Ser Phe Ser Gln Glu Thr Thr Lys Gly Ser Ala
                175                 180                 185
Phe Thr Thr Glu Ser Glu Thr Leu Pro Ala Ser Asn His Ser Gln Arg
            190                 195                 200
Ser Met Met Thr Ile Ser Thr Asp Ile Ala Val Leu Arg Pro Thr Gly
        205                 210                 215
Ser Asn Pro Gly Ile Leu Pro Ser Thr Ser Gln Leu Thr Thr Gln Lys
    220                 225                 230
Thr Thr Leu Thr Thr Ser Glu Ser Leu Gln Lys Thr Thr Lys Ser His
235                 240                 245                 250
Gln Ile Asn Ser Arg Gln Thr Leu Cys Tyr Ile Leu Asp Ala Ile Leu
                255                 260                 265
Phe Leu Tyr Gly Ile Val Leu Thr Leu Leu Tyr Cys Arg Leu Lys Ile
            270                 275                 280
Gln Val Arg Lys Ala Ala Ile Thr Ser Tyr Glu Lys Ser Asp Gly Val
        285                 290                 295
Tyr Thr Gly Leu Ser Thr Arg Asn Gln Glu Thr Tyr Glu Thr Leu Lys
    300                 305                 310
His Glu Lys Pro Pro Gln
315                 320

<210> 92
<211> 86
<212> PRT
<213> Homo sapiens

<220> 
<223> NFAM1 signaling domain

<400> 92
Leu Trp Asn Lys Lys Arg Met Arg Gly Pro Gly Lys Asp Pro Thr Arg
 1               5                  10                  15
Lys Cys Pro Asp Pro Arg Ser Ala Ser Ser Pro Lys Gln His Pro Ser
            20                  25                  30
Glu Ser Val Tyr Thr Ala Leu Gln Arg Arg Glu Thr Glu Val Tyr Ala
        35                  40                  45
Cys Ile Glu Asn Glu Asp Gly Ser Ser Pro Thr Ala Lys Gln Ser Pro
    50                  55                  60
Leu Ser Gln Glu Arg Pro His Arg Phe Glu Asp Asp Gly Glu Leu Asn
65                  70                  75                  80
Leu Val Tyr Glu Asn Leu
                85

<210> 93
<211> 386
<212> PRT
<213> Artificial Sequence

<220> 
<223> Tim4-Tim4-NFAM1 CER25 chimeric engulfment receptor

<220>
<221> SIGNAL         
<222> (1)...(22)

<400> 93
Met Ser Lys Gly Leu Leu Leu Leu Trp Leu Val Thr Glu Leu Trp Trp
        -20                 -15                 -10
Leu Tyr Leu Thr Pro Ala Ala Ser Glu Asp Thr Ile Ile Gly Phe Leu
    -5                   1               5                  10
Gly Gln Pro Val Thr Leu Pro Cys His Tyr Leu Ser Trp Ser Gln Ser
                15                  20                  25
Arg Asn Ser Met Cys Trp Gly Lys Gly Ser Cys Pro Asn Ser Lys Cys
            30                  35                  40
Asn Ala Glu Leu Leu Arg Thr Asp Gly Thr Arg Ile Ile Ser Arg Lys
        45                  50                  55
Ser Thr Lys Tyr Thr Leu Leu Gly Lys Val Gln Phe Gly Glu Val Ser
    60                  65                  70
Leu Thr Ile Ser Asn Thr Asn Arg Gly Asp Ser Gly Val Tyr Cys Cys
75                  80                  85                  90
Arg Ile Glu Val Pro Gly Trp Phe Asn Asp Val Lys Lys Asn Val Arg
                95                  100                 105
Leu Glu Leu Arg Arg Ala Thr Thr Thr Lys Lys Pro Thr Thr Thr Thr
            110                 115                 120
Arg Pro Thr Thr Thr Pro Tyr Val Thr Thr Thr Thr Pro Glu Leu Leu
        125                 130                 135
Pro Thr Thr Val Met Thr Thr Ser Val Leu Pro Thr Thr Thr Pro Pro
    140                 145                 150
Gln Thr Leu Ala Thr Thr Ala Phe Ser Thr Ala Val Thr Thr Cys Pro
155                 160                 165                 170
Ser Thr Thr Pro Gly Ser Phe Ser Gln Glu Thr Thr Lys Gly Ser Ala
                175                 180                 185
Phe Thr Thr Glu Ser Glu Thr Leu Pro Ala Ser Asn His Ser Gln Arg
            190                 195                 200
Ser Met Met Thr Ile Ser Thr Asp Ile Ala Val Leu Arg Pro Thr Gly
        205                 210                 215
Ser Asn Pro Gly Ile Leu Pro Ser Thr Ser Gln Leu Thr Thr Gln Lys
    220                 225                 230
Thr Thr Leu Thr Thr Ser Glu Ser Leu Gln Lys Thr Thr Lys Ser His
235                 240                 245                 250
Gln Ile Asn Ser Arg Gln Thr Ile Leu Ile Ile Ala Cys Cys Val Gly
                255                 260                 265
Phe Val Leu Met Val Leu Leu Phe Leu Ala Phe Leu Leu Trp Asn Lys
            270                 275                 280
Lys Arg Met Arg Gly Pro Gly Lys Asp Pro Thr Arg Lys Cys Pro Asp
        285                 290                 295
Pro Arg Ser Ala Ser Ser Pro Lys Gln His Pro Ser Glu Ser Val Tyr
    300                 305                 310
Thr Ala Leu Gln Arg Arg Glu Thr Glu Val Tyr Ala Cys Ile Glu Asn
315                 320                 325                 330
Glu Asp Gly Ser Ser Pro Thr Ala Lys Gln Ser Pro Leu Ser Gln Glu
                335                 340                 345
Arg Pro His Arg Phe Glu Asp Asp Gly Glu Leu Asn Leu Val Tyr Glu
            350                 355                 360
Asn Leu


<210> 94
<211> 85
<212> PRT
<213> Homo sapiens

<220> 
<223> BaFFR signaling domain

<400> 94
Ser Trp Arg Arg Arg Gln Arg Arg Leu Arg Gly Ala Ser Ser Ala Glu
 1               5                  10                  15
Ala Pro Asp Gly Asp Lys Asp Ala Pro Glu Pro Leu Asp Lys Val Ile
            20                  25                  30
Ile Leu Ser Pro Gly Ile Ser Asp Ala Thr Ala Pro Ala Trp Pro Pro
        35                  40                  45
Pro Gly Glu Asp Pro Gly Thr Thr Pro Pro Gly His Ser Val Pro Val
    50                  55                  60
Pro Ala Thr Glu Leu Gly Ser Thr Glu Leu Val Thr Thr Lys Thr Ala
65                  70                  75                  80
Gly Pro Glu Gln Gln
                85

<210> 95
<211> 540
<212> PRT
<213> Artificial Sequence

<220> 
<223> Tim4-tMyD88-BaFFR CER85 chimeric engulfment
      receptor

<220>
<221> SIGNAL         
<222> (1)...(22)

<400> 95
Met Ser Lys Gly Leu Leu Leu Leu Trp Leu Val Thr Glu Leu Trp Trp
        -20                 -15                 -10
Leu Tyr Leu Thr Pro Ala Ala Ser Glu Asp Thr Ile Ile Gly Phe Leu
    -5                   1               5                  10
Gly Gln Pro Val Thr Leu Pro Cys His Tyr Leu Ser Trp Ser Gln Ser
                15                  20                  25
Arg Asn Ser Met Cys Trp Gly Lys Gly Ser Cys Pro Asn Ser Lys Cys
            30                  35                  40
Asn Ala Glu Leu Leu Arg Thr Asp Gly Thr Arg Ile Ile Ser Arg Lys
        45                  50                  55
Ser Thr Lys Tyr Thr Leu Leu Gly Lys Val Gln Phe Gly Glu Val Ser
    60                  65                  70
Leu Thr Ile Ser Asn Thr Asn Arg Gly Asp Ser Gly Val Tyr Cys Cys
75                  80                  85                  90
Arg Ile Glu Val Pro Gly Trp Phe Asn Asp Val Lys Lys Asn Val Arg
                95                  100                 105
Leu Glu Leu Arg Arg Ala Thr Thr Thr Lys Lys Pro Thr Thr Thr Thr
            110                 115                 120
Arg Pro Thr Thr Thr Pro Tyr Val Thr Thr Thr Thr Pro Glu Leu Leu
        125                 130                 135
Pro Thr Thr Val Met Thr Thr Ser Val Leu Pro Thr Thr Thr Pro Pro
    140                 145                 150
Gln Thr Leu Ala Thr Thr Ala Phe Ser Thr Ala Val Thr Thr Cys Pro
155                 160                 165                 170
Ser Thr Thr Pro Gly Ser Phe Ser Gln Glu Thr Thr Lys Gly Ser Ala
                175                 180                 185
Phe Thr Thr Glu Ser Glu Thr Leu Pro Ala Ser Asn His Ser Gln Arg
            190                 195                 200
Ser Met Met Thr Ile Ser Thr Asp Ile Ala Val Leu Arg Pro Thr Gly
        205                 210                 215
Ser Asn Pro Gly Ile Leu Pro Ser Thr Ser Gln Leu Thr Thr Gln Lys
    220                 225                 230
Thr Thr Leu Thr Thr Ser Glu Ser Leu Gln Lys Thr Thr Lys Ser His
235                 240                 245                 250
Gln Ile Asn Ser Arg Gln Thr Ile Leu Ile Ile Ala Cys Cys Val Gly
                255                 260                 265
Phe Val Leu Met Val Leu Leu Phe Leu Ala Phe Leu Met Ala Ala Gly
            270                 275                 280
Gly Pro Gly Ala Gly Ser Ala Ala Pro Val Ser Ser Thr Ser Ser Leu
        285                 290                 295
Pro Leu Ala Ala Leu Asn Met Arg Val Arg Arg Arg Leu Ser Leu Phe
    300                 305                 310
Leu Asn Val Arg Thr Gln Val Ala Ala Asp Trp Thr Ala Leu Ala Glu
315                 320                 325                 330
Glu Met Asp Phe Glu Tyr Leu Glu Ile Arg Gln Leu Glu Thr Gln Ala
                335                 340                 345
Asp Pro Thr Gly Arg Leu Leu Asp Ala Trp Gln Gly Arg Pro Gly Ala
            350                 355                 360
Ser Val Gly Arg Leu Leu Glu Leu Leu Thr Lys Leu Gly Arg Asp Asp
        365                 370                 375
Val Leu Leu Glu Leu Gly Pro Ser Ile Glu Glu Asp Cys Gln Lys Tyr
    380                 385                 390
Ile Leu Lys Gln Gln Gln Glu Glu Ala Glu Lys Pro Leu Gln Val Ala
395                 400                 405                 410
Ala Val Asp Ser Ser Val Pro Arg Thr Ala Glu Leu Ala Gly Ile Thr
                415                 420                 425
Thr Leu Asp Asp Pro Leu Gly Ser Trp Arg Arg Arg Gln Arg Arg Leu
            430                 435                 440
Arg Gly Ala Ser Ser Ala Glu Ala Pro Asp Gly Asp Lys Asp Ala Pro
        445                 450                 455
Glu Pro Leu Asp Lys Val Ile Ile Leu Ser Pro Gly Ile Ser Asp Ala
    460                 465                 470
Thr Ala Pro Ala Trp Pro Pro Pro Gly Glu Asp Pro Gly Thr Thr Pro
475                 480                 485                 490
Pro Gly His Ser Val Pro Val Pro Ala Thr Glu Leu Gly Ser Thr Glu
                495                 500                 505
Leu Val Thr Thr Lys Thr Ala Gly Pro Glu Gln Gln
            510                 515

<210> 96
<211> 507
<212> PRT
<213> Artificial Sequence

<220> 
<223> Tim4-tMyD88-Dap12 CER86 chimeric engulfment
      receptor

<220>
<221> SIGNAL         
<222> (1)...(22)

<400> 96
Met Ser Lys Gly Leu Leu Leu Leu Trp Leu Val Thr Glu Leu Trp Trp
        -20                 -15                 -10
Leu Tyr Leu Thr Pro Ala Ala Ser Glu Asp Thr Ile Ile Gly Phe Leu
    -5                   1               5                  10
Gly Gln Pro Val Thr Leu Pro Cys His Tyr Leu Ser Trp Ser Gln Ser
                15                  20                  25
Arg Asn Ser Met Cys Trp Gly Lys Gly Ser Cys Pro Asn Ser Lys Cys
            30                  35                  40
Asn Ala Glu Leu Leu Arg Thr Asp Gly Thr Arg Ile Ile Ser Arg Lys
        45                  50                  55
Ser Thr Lys Tyr Thr Leu Leu Gly Lys Val Gln Phe Gly Glu Val Ser
    60                  65                  70
Leu Thr Ile Ser Asn Thr Asn Arg Gly Asp Ser Gly Val Tyr Cys Cys
75                  80                  85                  90
Arg Ile Glu Val Pro Gly Trp Phe Asn Asp Val Lys Lys Asn Val Arg
                95                  100                 105
Leu Glu Leu Arg Arg Ala Thr Thr Thr Lys Lys Pro Thr Thr Thr Thr
            110                 115                 120
Arg Pro Thr Thr Thr Pro Tyr Val Thr Thr Thr Thr Pro Glu Leu Leu
        125                 130                 135
Pro Thr Thr Val Met Thr Thr Ser Val Leu Pro Thr Thr Thr Pro Pro
    140                 145                 150
Gln Thr Leu Ala Thr Thr Ala Phe Ser Thr Ala Val Thr Thr Cys Pro
155                 160                 165                 170
Ser Thr Thr Pro Gly Ser Phe Ser Gln Glu Thr Thr Lys Gly Ser Ala
                175                 180                 185
Phe Thr Thr Glu Ser Glu Thr Leu Pro Ala Ser Asn His Ser Gln Arg
            190                 195                 200
Ser Met Met Thr Ile Ser Thr Asp Ile Ala Val Leu Arg Pro Thr Gly
        205                 210                 215
Ser Asn Pro Gly Ile Leu Pro Ser Thr Ser Gln Leu Thr Thr Gln Lys
    220                 225                 230
Thr Thr Leu Thr Thr Ser Glu Ser Leu Gln Lys Thr Thr Lys Ser His
235                 240                 245                 250
Gln Ile Asn Ser Arg Gln Thr Ile Leu Ile Ile Ala Cys Cys Val Gly
                255                 260                 265
Phe Val Leu Met Val Leu Leu Phe Leu Ala Phe Leu Met Ala Ala Gly
            270                 275                 280
Gly Pro Gly Ala Gly Ser Ala Ala Pro Val Ser Ser Thr Ser Ser Leu
        285                 290                 295
Pro Leu Ala Ala Leu Asn Met Arg Val Arg Arg Arg Leu Ser Leu Phe
    300                 305                 310
Leu Asn Val Arg Thr Gln Val Ala Ala Asp Trp Thr Ala Leu Ala Glu
315                 320                 325                 330
Glu Met Asp Phe Glu Tyr Leu Glu Ile Arg Gln Leu Glu Thr Gln Ala
                335                 340                 345
Asp Pro Thr Gly Arg Leu Leu Asp Ala Trp Gln Gly Arg Pro Gly Ala
            350                 355                 360
Ser Val Gly Arg Leu Leu Glu Leu Leu Thr Lys Leu Gly Arg Asp Asp
        365                 370                 375
Val Leu Leu Glu Leu Gly Pro Ser Ile Glu Glu Asp Cys Gln Lys Tyr
    380                 385                 390
Ile Leu Lys Gln Gln Gln Glu Glu Ala Glu Lys Pro Leu Gln Val Ala
395                 400                 405                 410
Ala Val Asp Ser Ser Val Pro Arg Thr Ala Glu Leu Ala Gly Ile Thr
                415                 420                 425
Thr Leu Asp Asp Pro Leu Gly Tyr Phe Leu Gly Arg Leu Val Pro Arg
            430                 435                 440
Gly Arg Gly Ala Ala Glu Ala Ala Thr Arg Lys Gln Arg Ile Thr Glu
        445                 450                 455
Thr Glu Ser Pro Tyr Gln Glu Leu Gln Gly Gln Arg Ser Asp Val Tyr
    460                 465                 470
Ser Asp Leu Asn Thr Gln Arg Pro Tyr Tyr Lys
475                 480                 485

<210> 97
<211> 29
<212> PRT
<213> Homo sapiens

<220> 
<223> CD79b signaling domain

<400> 97
Asp Ser Lys Ala Gly Met Glu Glu Asp His Thr Tyr Glu Gly Leu Asp
 1               5                  10                  15
Ile Asp Gln Thr Ala Thr Tyr Glu Asp Ile Val Thr Leu
            20                  25

<210> 98
<211> 484
<212> PRT
<213> Artificial Sequence

<220> 
<223> Tim4-tMyD88-CD79b CER89 chimeric engulfment
      receptor

<220>
<221> SIGNAL         
<222> (1)...(22)

<400> 98
Met Ser Lys Gly Leu Leu Leu Leu Trp Leu Val Thr Glu Leu Trp Trp
        -20                 -15                 -10
Leu Tyr Leu Thr Pro Ala Ala Ser Glu Asp Thr Ile Ile Gly Phe Leu
    -5                   1               5                  10
Gly Gln Pro Val Thr Leu Pro Cys His Tyr Leu Ser Trp Ser Gln Ser
                15                  20                  25
Arg Asn Ser Met Cys Trp Gly Lys Gly Ser Cys Pro Asn Ser Lys Cys
            30                  35                  40
Asn Ala Glu Leu Leu Arg Thr Asp Gly Thr Arg Ile Ile Ser Arg Lys
        45                  50                  55
Ser Thr Lys Tyr Thr Leu Leu Gly Lys Val Gln Phe Gly Glu Val Ser
    60                  65                  70
Leu Thr Ile Ser Asn Thr Asn Arg Gly Asp Ser Gly Val Tyr Cys Cys
75                  80                  85                  90
Arg Ile Glu Val Pro Gly Trp Phe Asn Asp Val Lys Lys Asn Val Arg
                95                  100                 105
Leu Glu Leu Arg Arg Ala Thr Thr Thr Lys Lys Pro Thr Thr Thr Thr
            110                 115                 120
Arg Pro Thr Thr Thr Pro Tyr Val Thr Thr Thr Thr Pro Glu Leu Leu
        125                 130                 135
Pro Thr Thr Val Met Thr Thr Ser Val Leu Pro Thr Thr Thr Pro Pro
    140                 145                 150
Gln Thr Leu Ala Thr Thr Ala Phe Ser Thr Ala Val Thr Thr Cys Pro
155                 160                 165                 170
Ser Thr Thr Pro Gly Ser Phe Ser Gln Glu Thr Thr Lys Gly Ser Ala
                175                 180                 185
Phe Thr Thr Glu Ser Glu Thr Leu Pro Ala Ser Asn His Ser Gln Arg
            190                 195                 200
Ser Met Met Thr Ile Ser Thr Asp Ile Ala Val Leu Arg Pro Thr Gly
        205                 210                 215
Ser Asn Pro Gly Ile Leu Pro Ser Thr Ser Gln Leu Thr Thr Gln Lys
    220                 225                 230
Thr Thr Leu Thr Thr Ser Glu Ser Leu Gln Lys Thr Thr Lys Ser His
235                 240                 245                 250
Gln Ile Asn Ser Arg Gln Thr Ile Leu Ile Ile Ala Cys Cys Val Gly
                255                 260                 265
Phe Val Leu Met Val Leu Leu Phe Leu Ala Phe Leu Met Ala Ala Gly
            270                 275                 280
Gly Pro Gly Ala Gly Ser Ala Ala Pro Val Ser Ser Thr Ser Ser Leu
        285                 290                 295
Pro Leu Ala Ala Leu Asn Met Arg Val Arg Arg Arg Leu Ser Leu Phe
    300                 305                 310
Leu Asn Val Arg Thr Gln Val Ala Ala Asp Trp Thr Ala Leu Ala Glu
315                 320                 325                 330
Glu Met Asp Phe Glu Tyr Leu Glu Ile Arg Gln Leu Glu Thr Gln Ala
                335                 340                 345
Asp Pro Thr Gly Arg Leu Leu Asp Ala Trp Gln Gly Arg Pro Gly Ala
            350                 355                 360
Ser Val Gly Arg Leu Leu Glu Leu Leu Thr Lys Leu Gly Arg Asp Asp
        365                 370                 375
Val Leu Leu Glu Leu Gly Pro Ser Ile Glu Glu Asp Cys Gln Lys Tyr
    380                 385                 390
Ile Leu Lys Gln Gln Gln Glu Glu Ala Glu Lys Pro Leu Gln Val Ala
395                 400                 405                 410
Ala Val Asp Ser Ser Val Pro Arg Thr Ala Glu Leu Ala Gly Ile Thr
                415                 420                 425
Thr Leu Asp Asp Pro Leu Gly Asp Ser Lys Ala Gly Met Glu Glu Asp
            430                 435                 440
His Thr Tyr Glu Gly Leu Asp Ile Asp Gln Thr Ala Thr Tyr Glu Asp
        445                 450                 455
Ile Val Thr Leu
    460

<210> 99
<211> 465
<212> DNA
<213> Homo sapiens

<220> 
<223> truncated MyD88 signaling domain

<400> 99
atggctgcag gaggtcccgg cgcggggtct gcggccccgg tctcctccac atcctccctt      60
cccctggctg ctctcaacat gcgagtgcgg cgccgcctgt ctctgttctt gaacgtgcgg     120
acacaggtgg cggccgactg gaccgcgctg gcggaggaga tggactttga gtacttggag     180
atccggcaac tggagacaca agcggacccc actggcaggc tgctggacgc ctggcaggga     240
cgccctggcg cctctgtagg ccgactgctc gagctgctta ccaagctggg ccgcgacgac     300
gtgctgctgg agctgggacc cagcattgag gaggattgcc aaaagtatat cttgaagcag     360
cagcaggagg aggctgagaa gcctttacag gtggccgctg tagacagcag tgtcccacgg     420
acagcagagc tggcgggcat caccacactt gatgaccccc tgggg                     465

<210> 100
<211> 541
<212> PRT
<213> Artificial Sequence

<220> 
<223> Tim4-tMyD88-NFAM1 CER90 chimeric engulfment
      receptor

<220>
<221> SIGNAL         
<222> (1)...(22)

<400> 100
Met Ser Lys Gly Leu Leu Leu Leu Trp Leu Val Thr Glu Leu Trp Trp
        -20                 -15                 -10
Leu Tyr Leu Thr Pro Ala Ala Ser Glu Asp Thr Ile Ile Gly Phe Leu
    -5                   1               5                  10
Gly Gln Pro Val Thr Leu Pro Cys His Tyr Leu Ser Trp Ser Gln Ser
                15                  20                  25
Arg Asn Ser Met Cys Trp Gly Lys Gly Ser Cys Pro Asn Ser Lys Cys
            30                  35                  40
Asn Ala Glu Leu Leu Arg Thr Asp Gly Thr Arg Ile Ile Ser Arg Lys
        45                  50                  55
Ser Thr Lys Tyr Thr Leu Leu Gly Lys Val Gln Phe Gly Glu Val Ser
    60                  65                  70
Leu Thr Ile Ser Asn Thr Asn Arg Gly Asp Ser Gly Val Tyr Cys Cys
75                  80                  85                  90
Arg Ile Glu Val Pro Gly Trp Phe Asn Asp Val Lys Lys Asn Val Arg
                95                  100                 105
Leu Glu Leu Arg Arg Ala Thr Thr Thr Lys Lys Pro Thr Thr Thr Thr
            110                 115                 120
Arg Pro Thr Thr Thr Pro Tyr Val Thr Thr Thr Thr Pro Glu Leu Leu
        125                 130                 135
Pro Thr Thr Val Met Thr Thr Ser Val Leu Pro Thr Thr Thr Pro Pro
    140                 145                 150
Gln Thr Leu Ala Thr Thr Ala Phe Ser Thr Ala Val Thr Thr Cys Pro
155                 160                 165                 170
Ser Thr Thr Pro Gly Ser Phe Ser Gln Glu Thr Thr Lys Gly Ser Ala
                175                 180                 185
Phe Thr Thr Glu Ser Glu Thr Leu Pro Ala Ser Asn His Ser Gln Arg
            190                 195                 200
Ser Met Met Thr Ile Ser Thr Asp Ile Ala Val Leu Arg Pro Thr Gly
        205                 210                 215
Ser Asn Pro Gly Ile Leu Pro Ser Thr Ser Gln Leu Thr Thr Gln Lys
    220                 225                 230
Thr Thr Leu Thr Thr Ser Glu Ser Leu Gln Lys Thr Thr Lys Ser His
235                 240                 245                 250
Gln Ile Asn Ser Arg Gln Thr Ile Leu Ile Ile Ala Cys Cys Val Gly
                255                 260                 265
Phe Val Leu Met Val Leu Leu Phe Leu Ala Phe Leu Met Ala Ala Gly
            270                 275                 280
Gly Pro Gly Ala Gly Ser Ala Ala Pro Val Ser Ser Thr Ser Ser Leu
        285                 290                 295
Pro Leu Ala Ala Leu Asn Met Arg Val Arg Arg Arg Leu Ser Leu Phe
    300                 305                 310
Leu Asn Val Arg Thr Gln Val Ala Ala Asp Trp Thr Ala Leu Ala Glu
315                 320                 325                 330
Glu Met Asp Phe Glu Tyr Leu Glu Ile Arg Gln Leu Glu Thr Gln Ala
                335                 340                 345
Asp Pro Thr Gly Arg Leu Leu Asp Ala Trp Gln Gly Arg Pro Gly Ala
            350                 355                 360
Ser Val Gly Arg Leu Leu Glu Leu Leu Thr Lys Leu Gly Arg Asp Asp
        365                 370                 375
Val Leu Leu Glu Leu Gly Pro Ser Ile Glu Glu Asp Cys Gln Lys Tyr
    380                 385                 390
Ile Leu Lys Gln Gln Gln Glu Glu Ala Glu Lys Pro Leu Gln Val Ala
395                 400                 405                 410
Ala Val Asp Ser Ser Val Pro Arg Thr Ala Glu Leu Ala Gly Ile Thr
                415                 420                 425
Thr Leu Asp Asp Pro Leu Gly Leu Trp Asn Lys Lys Arg Met Arg Gly
            430                 435                 440
Pro Gly Lys Asp Pro Thr Arg Lys Cys Pro Asp Pro Arg Ser Ala Ser
        445                 450                 455
Ser Pro Lys Gln His Pro Ser Glu Ser Val Tyr Thr Ala Leu Gln Arg
    460                 465                 470
Arg Glu Thr Glu Val Tyr Ala Cys Ile Glu Asn Glu Asp Gly Ser Ser
475                 480                 485                 490
Pro Thr Ala Lys Gln Ser Pro Leu Ser Gln Glu Arg Pro His Arg Phe
                495                 500                 505
Glu Asp Asp Gly Glu Leu Asn Leu Val Tyr Glu Asn Leu
            510                 515

<210> 101
<211> 805
<212> PRT
<213> Artificial Sequence

<220> 
<223> Tim4-MerTk-CD79b CER95 chimeric engulfment
      receptor

<220>
<221> SIGNAL         
<222> (1)...(22)

<400> 101
Met Ser Lys Gly Leu Leu Leu Leu Trp Leu Val Thr Glu Leu Trp Trp
        -20                 -15                 -10
Leu Tyr Leu Thr Pro Ala Ala Ser Glu Asp Thr Ile Ile Gly Phe Leu
    -5                   1               5                  10
Gly Gln Pro Val Thr Leu Pro Cys His Tyr Leu Ser Trp Ser Gln Ser
                15                  20                  25
Arg Asn Ser Met Cys Trp Gly Lys Gly Ser Cys Pro Asn Ser Lys Cys
            30                  35                  40
Asn Ala Glu Leu Leu Arg Thr Asp Gly Thr Arg Ile Ile Ser Arg Lys
        45                  50                  55
Ser Thr Lys Tyr Thr Leu Leu Gly Lys Val Gln Phe Gly Glu Val Ser
    60                  65                  70
Leu Thr Ile Ser Asn Thr Asn Arg Gly Asp Ser Gly Val Tyr Cys Cys
75                  80                  85                  90
Arg Ile Glu Val Pro Gly Trp Phe Asn Asp Val Lys Lys Asn Val Arg
                95                  100                 105
Leu Glu Leu Arg Arg Ala Thr Thr Thr Lys Lys Pro Thr Thr Thr Thr
            110                 115                 120
Arg Pro Thr Thr Thr Pro Tyr Val Thr Thr Thr Thr Pro Glu Leu Leu
        125                 130                 135
Pro Thr Thr Val Met Thr Thr Ser Val Leu Pro Thr Thr Thr Pro Pro
    140                 145                 150
Gln Thr Leu Ala Thr Thr Ala Phe Ser Thr Ala Val Thr Thr Cys Pro
155                 160                 165                 170
Ser Thr Thr Pro Gly Ser Phe Ser Gln Glu Thr Thr Lys Gly Ser Ala
                175                 180                 185
Phe Thr Thr Glu Ser Glu Thr Leu Pro Ala Ser Asn His Ser Gln Arg
            190                 195                 200
Ser Met Met Thr Ile Ser Thr Asp Ile Ala Val Leu Arg Pro Thr Gly
        205                 210                 215
Ser Asn Pro Gly Ile Leu Pro Ser Thr Ser Gln Leu Thr Thr Gln Lys
    220                 225                 230
Thr Thr Leu Thr Thr Ser Glu Ser Leu Gln Lys Thr Thr Lys Ser His
235                 240                 245                 250
Gln Ile Asn Ser Arg Gln Thr Ile Leu Ile Ile Ala Cys Cys Val Gly
                255                 260                 265
Phe Val Leu Met Val Leu Leu Phe Leu Ala Phe Leu Ala Leu Arg Arg
            270                 275                 280
Arg Val Gln Glu Thr Lys Phe Gly Gly Ala Phe Ser Glu Glu Asp Ser
        285                 290                 295
Gln Leu Val Val Asn Tyr Arg Ala Lys Lys Ser Phe Cys Arg Arg Ala
    300                 305                 310
Ile Glu Leu Thr Leu Gln Ser Leu Gly Val Ser Glu Glu Leu Gln Asn
315                 320                 325                 330
Lys Leu Glu Asp Val Val Ile Asp Arg Asn Leu Leu Val Leu Gly Lys
                335                 340                 345
Val Leu Gly Glu Gly Glu Phe Gly Ser Val Met Glu Gly Asn Leu Lys
            350                 355                 360
Gln Glu Asp Gly Thr Ser Gln Lys Val Ala Val Lys Thr Met Lys Leu
        365                 370                 375
Asp Asn Phe Ser Gln Arg Glu Ile Glu Glu Phe Leu Ser Glu Ala Ala
    380                 385                 390
Cys Met Lys Asp Phe Asn His Pro Asn Val Ile Arg Leu Leu Gly Val
395                 400                 405                 410
Cys Ile Glu Leu Ser Ser Gln Gly Ile Pro Lys Pro Met Val Ile Leu
                415                 420                 425
Pro Phe Met Lys Tyr Gly Asp Leu His Thr Phe Leu Leu Tyr Ser Arg
            430                 435                 440
Leu Asn Thr Gly Pro Lys Tyr Ile His Leu Gln Thr Leu Leu Lys Phe
        445                 450                 455
Met Met Asp Ile Ala Gln Gly Met Glu Tyr Leu Ser Asn Arg Asn Phe
    460                 465                 470
Leu His Arg Asp Leu Ala Ala Arg Asn Cys Met Leu Arg Asp Asp Met
475                 480                 485                 490
Thr Val Cys Val Ala Asp Phe Gly Leu Ser Lys Lys Ile Tyr Ser Gly
                495                 500                 505
Asp Tyr Tyr Arg Gln Gly Arg Ile Ala Lys Met Pro Val Lys Trp Ile
            510                 515                 520
Ala Ile Glu Ser Leu Ala Asp Arg Val Tyr Thr Ser Lys Ser Asp Val
        525                 530                 535
Trp Ala Phe Gly Val Thr Met Trp Glu Ile Thr Thr Arg Gly Met Thr
    540                 545                 550
Pro Tyr Pro Gly Val Gln Asn His Glu Met Tyr Asp Tyr Leu Leu His
555                 560                 565                 570
Gly His Arg Leu Lys Gln Pro Glu Asp Cys Leu Asp Glu Leu Tyr Asp
                575                 580                 585
Ile Met Tyr Ser Cys Trp Ser Ala Asp Pro Leu Asp Arg Pro Thr Phe
            590                 595                 600
Ser Val Leu Arg Leu Gln Leu Glu Lys Leu Ser Glu Ser Leu Pro Asp
        605                 610                 615
Ala Gln Asp Lys Glu Ser Ile Ile Tyr Ile Asn Thr Gln Leu Leu Glu
    620                 625                 630
Ser Cys Glu Gly Ile Ala Asn Gly Pro Ser Leu Thr Gly Leu Asp Met
635                 640                 645                 650
Asn Ile Asp Pro Asp Ser Ile Ile Ala Ser Cys Thr Pro Gly Ala Ala
                655                 660                 665
Val Ser Val Val Thr Ala Glu Val His Glu Asn Asn Leu Arg Glu Glu
            670                 675                 680
Arg Tyr Ile Leu Asn Gly Gly Asn Glu Glu Trp Glu Asp Val Ser Ser
        685                 690                 695
Thr Pro Phe Ala Ala Val Thr Pro Glu Lys Asp Gly Val Leu Pro Glu
    700                 705                 710
Asp Arg Leu Thr Lys Asn Gly Val Ser Trp Ser His His Ser Thr Leu
715                 720                 725                 730
Pro Leu Gly Ser Pro Ser Pro Asp Glu Leu Leu Phe Val Asp Asp Ser
                735                 740                 745
Leu Glu Asp Ser Glu Val Leu Met Asp Ser Lys Ala Gly Met Glu Glu
            750                 755                 760
Asp His Thr Tyr Glu Gly Leu Asp Ile Asp Gln Thr Ala Thr Tyr Glu
        765                 770                 775
Asp Ile Val Thr Leu
    780

<210> 102
<211> 862
<212> PRT
<213> Artificial Sequence

<220> 
<223> Tim4-MerTk-NFAM1 CER96 chimeric engulfment
      receptor

<220>
<221> SIGNAL         
<222> (1)...(22)

<400> 102
Met Ser Lys Gly Leu Leu Leu Leu Trp Leu Val Thr Glu Leu Trp Trp
        -20                 -15                 -10
Leu Tyr Leu Thr Pro Ala Ala Ser Glu Asp Thr Ile Ile Gly Phe Leu
    -5                   1               5                  10
Gly Gln Pro Val Thr Leu Pro Cys His Tyr Leu Ser Trp Ser Gln Ser
                15                  20                  25
Arg Asn Ser Met Cys Trp Gly Lys Gly Ser Cys Pro Asn Ser Lys Cys
            30                  35                  40
Asn Ala Glu Leu Leu Arg Thr Asp Gly Thr Arg Ile Ile Ser Arg Lys
        45                  50                  55
Ser Thr Lys Tyr Thr Leu Leu Gly Lys Val Gln Phe Gly Glu Val Ser
    60                  65                  70
Leu Thr Ile Ser Asn Thr Asn Arg Gly Asp Ser Gly Val Tyr Cys Cys
75                  80                  85                  90
Arg Ile Glu Val Pro Gly Trp Phe Asn Asp Val Lys Lys Asn Val Arg
                95                  100                 105
Leu Glu Leu Arg Arg Ala Thr Thr Thr Lys Lys Pro Thr Thr Thr Thr
            110                 115                 120
Arg Pro Thr Thr Thr Pro Tyr Val Thr Thr Thr Thr Pro Glu Leu Leu
        125                 130                 135
Pro Thr Thr Val Met Thr Thr Ser Val Leu Pro Thr Thr Thr Pro Pro
    140                 145                 150
Gln Thr Leu Ala Thr Thr Ala Phe Ser Thr Ala Val Thr Thr Cys Pro
155                 160                 165                 170
Ser Thr Thr Pro Gly Ser Phe Ser Gln Glu Thr Thr Lys Gly Ser Ala
                175                 180                 185
Phe Thr Thr Glu Ser Glu Thr Leu Pro Ala Ser Asn His Ser Gln Arg
            190                 195                 200
Ser Met Met Thr Ile Ser Thr Asp Ile Ala Val Leu Arg Pro Thr Gly
        205                 210                 215
Ser Asn Pro Gly Ile Leu Pro Ser Thr Ser Gln Leu Thr Thr Gln Lys
    220                 225                 230
Thr Thr Leu Thr Thr Ser Glu Ser Leu Gln Lys Thr Thr Lys Ser His
235                 240                 245                 250
Gln Ile Asn Ser Arg Gln Thr Ile Leu Ile Ile Ala Cys Cys Val Gly
                255                 260                 265
Phe Val Leu Met Val Leu Leu Phe Leu Ala Phe Leu Ala Leu Arg Arg
            270                 275                 280
Arg Val Gln Glu Thr Lys Phe Gly Gly Ala Phe Ser Glu Glu Asp Ser
        285                 290                 295
Gln Leu Val Val Asn Tyr Arg Ala Lys Lys Ser Phe Cys Arg Arg Ala
    300                 305                 310
Ile Glu Leu Thr Leu Gln Ser Leu Gly Val Ser Glu Glu Leu Gln Asn
315                 320                 325                 330
Lys Leu Glu Asp Val Val Ile Asp Arg Asn Leu Leu Val Leu Gly Lys
                335                 340                 345
Val Leu Gly Glu Gly Glu Phe Gly Ser Val Met Glu Gly Asn Leu Lys
            350                 355                 360
Gln Glu Asp Gly Thr Ser Gln Lys Val Ala Val Lys Thr Met Lys Leu
        365                 370                 375
Asp Asn Phe Ser Gln Arg Glu Ile Glu Glu Phe Leu Ser Glu Ala Ala
    380                 385                 390
Cys Met Lys Asp Phe Asn His Pro Asn Val Ile Arg Leu Leu Gly Val
395                 400                 405                 410
Cys Ile Glu Leu Ser Ser Gln Gly Ile Pro Lys Pro Met Val Ile Leu
                415                 420                 425
Pro Phe Met Lys Tyr Gly Asp Leu His Thr Phe Leu Leu Tyr Ser Arg
            430                 435                 440
Leu Asn Thr Gly Pro Lys Tyr Ile His Leu Gln Thr Leu Leu Lys Phe
        445                 450                 455
Met Met Asp Ile Ala Gln Gly Met Glu Tyr Leu Ser Asn Arg Asn Phe
    460                 465                 470
Leu His Arg Asp Leu Ala Ala Arg Asn Cys Met Leu Arg Asp Asp Met
475                 480                 485                 490
Thr Val Cys Val Ala Asp Phe Gly Leu Ser Lys Lys Ile Tyr Ser Gly
                495                 500                 505
Asp Tyr Tyr Arg Gln Gly Arg Ile Ala Lys Met Pro Val Lys Trp Ile
            510                 515                 520
Ala Ile Glu Ser Leu Ala Asp Arg Val Tyr Thr Ser Lys Ser Asp Val
        525                 530                 535
Trp Ala Phe Gly Val Thr Met Trp Glu Ile Thr Thr Arg Gly Met Thr
    540                 545                 550
Pro Tyr Pro Gly Val Gln Asn His Glu Met Tyr Asp Tyr Leu Leu His
555                 560                 565                 570
Gly His Arg Leu Lys Gln Pro Glu Asp Cys Leu Asp Glu Leu Tyr Asp
                575                 580                 585
Ile Met Tyr Ser Cys Trp Ser Ala Asp Pro Leu Asp Arg Pro Thr Phe
            590                 595                 600
Ser Val Leu Arg Leu Gln Leu Glu Lys Leu Ser Glu Ser Leu Pro Asp
        605                 610                 615
Ala Gln Asp Lys Glu Ser Ile Ile Tyr Ile Asn Thr Gln Leu Leu Glu
    620                 625                 630
Ser Cys Glu Gly Ile Ala Asn Gly Pro Ser Leu Thr Gly Leu Asp Met
635                 640                 645                 650
Asn Ile Asp Pro Asp Ser Ile Ile Ala Ser Cys Thr Pro Gly Ala Ala
                655                 660                 665
Val Ser Val Val Thr Ala Glu Val His Glu Asn Asn Leu Arg Glu Glu
            670                 675                 680
Arg Tyr Ile Leu Asn Gly Gly Asn Glu Glu Trp Glu Asp Val Ser Ser
        685                 690                 695
Thr Pro Phe Ala Ala Val Thr Pro Glu Lys Asp Gly Val Leu Pro Glu
    700                 705                 710
Asp Arg Leu Thr Lys Asn Gly Val Ser Trp Ser His His Ser Thr Leu
715                 720                 725                 730
Pro Leu Gly Ser Pro Ser Pro Asp Glu Leu Leu Phe Val Asp Asp Ser
                735                 740                 745
Leu Glu Asp Ser Glu Val Leu Met Leu Trp Asn Lys Lys Arg Met Arg
            750                 755                 760
Gly Pro Gly Lys Asp Pro Thr Arg Lys Cys Pro Asp Pro Arg Ser Ala
        765                 770                 775
Ser Ser Pro Lys Gln His Pro Ser Glu Ser Val Tyr Thr Ala Leu Gln
    780                 785                 790
Arg Arg Glu Thr Glu Val Tyr Ala Cys Ile Glu Asn Glu Asp Gly Ser
795                 800                 805                 810
Ser Pro Thr Ala Lys Gln Ser Pro Leu Ser Gln Glu Arg Pro His Arg
                815                 820                 825
Phe Glu Asp Asp Gly Glu Leu Asn Leu Val Tyr Glu Asn Leu
            830                 835                 840

<210> 103
<211> 861
<212> PRT
<213> Artificial Sequence

<220> 
<223> Tim4-MERTK-BAFFR CER93 chimeric engulfment
      receptor

<220>
<221> SIGNAL         
<222> (1)...(22)

<400> 103
Met Ser Lys Gly Leu Leu Leu Leu Trp Leu Val Thr Glu Leu Trp Trp
        -20                 -15                 -10
Leu Tyr Leu Thr Pro Ala Ala Ser Glu Asp Thr Ile Ile Gly Phe Leu
    -5                   1               5                  10
Gly Gln Pro Val Thr Leu Pro Cys His Tyr Leu Ser Trp Ser Gln Ser
                15                  20                  25
Arg Asn Ser Met Cys Trp Gly Lys Gly Ser Cys Pro Asn Ser Lys Cys
            30                  35                  40
Asn Ala Glu Leu Leu Arg Thr Asp Gly Thr Arg Ile Ile Ser Arg Lys
        45                  50                  55
Ser Thr Lys Tyr Thr Leu Leu Gly Lys Val Gln Phe Gly Glu Val Ser
    60                  65                  70
Leu Thr Ile Ser Asn Thr Asn Arg Gly Asp Ser Gly Val Tyr Cys Cys
75                  80                  85                  90
Arg Ile Glu Val Pro Gly Trp Phe Asn Asp Val Lys Lys Asn Val Arg
                95                  100                 105
Leu Glu Leu Arg Arg Ala Thr Thr Thr Lys Lys Pro Thr Thr Thr Thr
            110                 115                 120
Arg Pro Thr Thr Thr Pro Tyr Val Thr Thr Thr Thr Pro Glu Leu Leu
        125                 130                 135
Pro Thr Thr Val Met Thr Thr Ser Val Leu Pro Thr Thr Thr Pro Pro
    140                 145                 150
Gln Thr Leu Ala Thr Thr Ala Phe Ser Thr Ala Val Thr Thr Cys Pro
155                 160                 165                 170
Ser Thr Thr Pro Gly Ser Phe Ser Gln Glu Thr Thr Lys Gly Ser Ala
                175                 180                 185
Phe Thr Thr Glu Ser Glu Thr Leu Pro Ala Ser Asn His Ser Gln Arg
            190                 195                 200
Ser Met Met Thr Ile Ser Thr Asp Ile Ala Val Leu Arg Pro Thr Gly
        205                 210                 215
Ser Asn Pro Gly Ile Leu Pro Ser Thr Ser Gln Leu Thr Thr Gln Lys
    220                 225                 230
Thr Thr Leu Thr Thr Ser Glu Ser Leu Gln Lys Thr Thr Lys Ser His
235                 240                 245                 250
Gln Ile Asn Ser Arg Gln Thr Ile Leu Ile Ile Ala Cys Cys Val Gly
                255                 260                 265
Phe Val Leu Met Val Leu Leu Phe Leu Ala Phe Leu Ala Leu Arg Arg
            270                 275                 280
Arg Val Gln Glu Thr Lys Phe Gly Gly Ala Phe Ser Glu Glu Asp Ser
        285                 290                 295
Gln Leu Val Val Asn Tyr Arg Ala Lys Lys Ser Phe Cys Arg Arg Ala
    300                 305                 310
Ile Glu Leu Thr Leu Gln Ser Leu Gly Val Ser Glu Glu Leu Gln Asn
315                 320                 325                 330
Lys Leu Glu Asp Val Val Ile Asp Arg Asn Leu Leu Val Leu Gly Lys
                335                 340                 345
Val Leu Gly Glu Gly Glu Phe Gly Ser Val Met Glu Gly Asn Leu Lys
            350                 355                 360
Gln Glu Asp Gly Thr Ser Gln Lys Val Ala Val Lys Thr Met Lys Leu
        365                 370                 375
Asp Asn Phe Ser Gln Arg Glu Ile Glu Glu Phe Leu Ser Glu Ala Ala
    380                 385                 390
Cys Met Lys Asp Phe Asn His Pro Asn Val Ile Arg Leu Leu Gly Val
395                 400                 405                 410
Cys Ile Glu Leu Ser Ser Gln Gly Ile Pro Lys Pro Met Val Ile Leu
                415                 420                 425
Pro Phe Met Lys Tyr Gly Asp Leu His Thr Phe Leu Leu Tyr Ser Arg
            430                 435                 440
Leu Asn Thr Gly Pro Lys Tyr Ile His Leu Gln Thr Leu Leu Lys Phe
        445                 450                 455
Met Met Asp Ile Ala Gln Gly Met Glu Tyr Leu Ser Asn Arg Asn Phe
    460                 465                 470
Leu His Arg Asp Leu Ala Ala Arg Asn Cys Met Leu Arg Asp Asp Met
475                 480                 485                 490
Thr Val Cys Val Ala Asp Phe Gly Leu Ser Lys Lys Ile Tyr Ser Gly
                495                 500                 505
Asp Tyr Tyr Arg Gln Gly Arg Ile Ala Lys Met Pro Val Lys Trp Ile
            510                 515                 520
Ala Ile Glu Ser Leu Ala Asp Arg Val Tyr Thr Ser Lys Ser Asp Val
        525                 530                 535
Trp Ala Phe Gly Val Thr Met Trp Glu Ile Thr Thr Arg Gly Met Thr
    540                 545                 550
Pro Tyr Pro Gly Val Gln Asn His Glu Met Tyr Asp Tyr Leu Leu His
555                 560                 565                 570
Gly His Arg Leu Lys Gln Pro Glu Asp Cys Leu Asp Glu Leu Tyr Asp
                575                 580                 585
Ile Met Tyr Ser Cys Trp Ser Ala Asp Pro Leu Asp Arg Pro Thr Phe
            590                 595                 600
Ser Val Leu Arg Leu Gln Leu Glu Lys Leu Ser Glu Ser Leu Pro Asp
        605                 610                 615
Ala Gln Asp Lys Glu Ser Ile Ile Tyr Ile Asn Thr Gln Leu Leu Glu
    620                 625                 630
Ser Cys Glu Gly Ile Ala Asn Gly Pro Ser Leu Thr Gly Leu Asp Met
635                 640                 645                 650
Asn Ile Asp Pro Asp Ser Ile Ile Ala Ser Cys Thr Pro Gly Ala Ala
                655                 660                 665
Val Ser Val Val Thr Ala Glu Val His Glu Asn Asn Leu Arg Glu Glu
            670                 675                 680
Arg Tyr Ile Leu Asn Gly Gly Asn Glu Glu Trp Glu Asp Val Ser Ser
        685                 690                 695
Thr Pro Phe Ala Ala Val Thr Pro Glu Lys Asp Gly Val Leu Pro Glu
    700                 705                 710
Asp Arg Leu Thr Lys Asn Gly Val Ser Trp Ser His His Ser Thr Leu
715                 720                 725                 730
Pro Leu Gly Ser Pro Ser Pro Asp Glu Leu Leu Phe Val Asp Asp Ser
                735                 740                 745
Leu Glu Asp Ser Glu Val Leu Met Ser Trp Arg Arg Arg Gln Arg Arg
            750                 755                 760
Leu Arg Gly Ala Ser Ser Ala Glu Ala Pro Asp Gly Asp Lys Asp Ala
        765                 770                 775
Pro Glu Pro Leu Asp Lys Val Ile Ile Leu Ser Pro Gly Ile Ser Asp
    780                 785                 790
Ala Thr Ala Pro Ala Trp Pro Pro Pro Gly Glu Asp Pro Gly Thr Thr
795                 800                 805                 810
Pro Pro Gly His Ser Val Pro Val Pro Ala Thr Glu Leu Gly Ser Thr
                815                 820                 825
Glu Leu Val Thr Thr Lys Thr Ala Gly Pro Glu Gln Gln
            830                 835

<210> 104
<211> 19
<212> PRT
<213> Artificial Sequence

<220> 
<223> P2A self-cleaving peptide

<400> 104
Ala Thr Asn Phe Ser Leu Leu Lys Gln Ala Gly Asp Val Glu Glu Asn
 1               5                  10                  15
Pro Gly Pro


<210> 105
<211> 692
<212> PRT
<213> Artificial Sequence

<220> 
<223> Tim4-tMyD88-P2A-Rab5a CER91 chimeric engulfment
      receptor

<220>
<221> SIGNAL         
<222> (1)...(22)

<400> 105
Met Ser Lys Gly Leu Leu Leu Leu Trp Leu Val Thr Glu Leu Trp Trp
        -20                 -15                 -10
Leu Tyr Leu Thr Pro Ala Ala Ser Glu Asp Thr Ile Ile Gly Phe Leu
    -5                   1               5                  10
Gly Gln Pro Val Thr Leu Pro Cys His Tyr Leu Ser Trp Ser Gln Ser
                15                  20                  25
Arg Asn Ser Met Cys Trp Gly Lys Gly Ser Cys Pro Asn Ser Lys Cys
            30                  35                  40
Asn Ala Glu Leu Leu Arg Thr Asp Gly Thr Arg Ile Ile Ser Arg Lys
        45                  50                  55
Ser Thr Lys Tyr Thr Leu Leu Gly Lys Val Gln Phe Gly Glu Val Ser
    60                  65                  70
Leu Thr Ile Ser Asn Thr Asn Arg Gly Asp Ser Gly Val Tyr Cys Cys
75                  80                  85                  90
Arg Ile Glu Val Pro Gly Trp Phe Asn Asp Val Lys Lys Asn Val Arg
                95                  100                 105
Leu Glu Leu Arg Arg Ala Thr Thr Thr Lys Lys Pro Thr Thr Thr Thr
            110                 115                 120
Arg Pro Thr Thr Thr Pro Tyr Val Thr Thr Thr Thr Pro Glu Leu Leu
        125                 130                 135
Pro Thr Thr Val Met Thr Thr Ser Val Leu Pro Thr Thr Thr Pro Pro
    140                 145                 150
Gln Thr Leu Ala Thr Thr Ala Phe Ser Thr Ala Val Thr Thr Cys Pro
155                 160                 165                 170
Ser Thr Thr Pro Gly Ser Phe Ser Gln Glu Thr Thr Lys Gly Ser Ala
                175                 180                 185
Phe Thr Thr Glu Ser Glu Thr Leu Pro Ala Ser Asn His Ser Gln Arg
            190                 195                 200
Ser Met Met Thr Ile Ser Thr Asp Ile Ala Val Leu Arg Pro Thr Gly
        205                 210                 215
Ser Asn Pro Gly Ile Leu Pro Ser Thr Ser Gln Leu Thr Thr Gln Lys
    220                 225                 230
Thr Thr Leu Thr Thr Ser Glu Ser Leu Gln Lys Thr Thr Lys Ser His
235                 240                 245                 250
Gln Ile Asn Ser Arg Gln Thr Ile Leu Ile Ile Ala Cys Cys Val Gly
                255                 260                 265
Phe Val Leu Met Val Leu Leu Phe Leu Ala Phe Leu Met Ala Ala Gly
            270                 275                 280
Gly Pro Gly Ala Gly Ser Ala Ala Pro Val Ser Ser Thr Ser Ser Leu
        285                 290                 295
Pro Leu Ala Ala Leu Asn Met Arg Val Arg Arg Arg Leu Ser Leu Phe
    300                 305                 310
Leu Asn Val Arg Thr Gln Val Ala Ala Asp Trp Thr Ala Leu Ala Glu
315                 320                 325                 330
Glu Met Asp Phe Glu Tyr Leu Glu Ile Arg Gln Leu Glu Thr Gln Ala
                335                 340                 345
Asp Pro Thr Gly Arg Leu Leu Asp Ala Trp Gln Gly Arg Pro Gly Ala
            350                 355                 360
Ser Val Gly Arg Leu Leu Glu Leu Leu Thr Lys Leu Gly Arg Asp Asp
        365                 370                 375
Val Leu Leu Glu Leu Gly Pro Ser Ile Glu Glu Asp Cys Gln Lys Tyr
    380                 385                 390
Ile Leu Lys Gln Gln Gln Glu Glu Ala Glu Lys Pro Leu Gln Val Ala
395                 400                 405                 410
Ala Val Asp Ser Ser Val Pro Arg Thr Ala Glu Leu Ala Gly Ile Thr
                415                 420                 425
Thr Leu Asp Asp Pro Leu Gly Gly Ser Gly Ala Thr Asn Phe Ser Leu
            430                 435                 440
Leu Lys Gln Ala Gly Asp Val Glu Glu Asn Pro Gly Pro Met Ala Ser
        445                 450                 455
Arg Gly Ala Thr Arg Pro Asn Gly Pro Asn Thr Gly Asn Lys Ile Cys
    460                 465                 470
Gln Phe Lys Leu Val Leu Leu Gly Glu Ser Ala Val Gly Lys Ser Ser
475                 480                 485                 490
Leu Val Leu Arg Phe Val Lys Gly Gln Phe His Glu Phe Gln Glu Ser
                495                 500                 505
Thr Ile Gly Ala Ala Phe Leu Thr Gln Thr Val Cys Leu Asp Asp Thr
            510                 515                 520
Thr Val Lys Phe Glu Ile Trp Asp Thr Ala Gly Gln Glu Arg Tyr His
        525                 530                 535
Ser Leu Ala Pro Met Tyr Tyr Arg Gly Ala Gln Ala Ala Ile Val Val
    540                 545                 550
Tyr Asp Ile Thr Asn Glu Glu Ser Phe Ala Arg Ala Lys Asn Trp Val
555                 560                 565                 570
Lys Glu Leu Gln Arg Gln Ala Ser Pro Asn Ile Val Ile Ala Leu Ser
                575                 580                 585
Gly Asn Lys Ala Asp Leu Ala Asn Lys Arg Ala Val Asp Phe Gln Glu
            590                 595                 600
Ala Gln Ser Tyr Ala Asp Asp Asn Ser Leu Leu Phe Met Glu Thr Ser
        605                 610                 615
Ala Lys Thr Ser Met Asn Val Asn Glu Ile Phe Met Ala Ile Ala Lys
    620                 625                 630
Lys Leu Pro Lys Asn Glu Pro Gln Asn Pro Gly Ala Asn Ser Ala Arg
635                 640                 645                 650
Gly Arg Gly Val Asp Leu Thr Glu Pro Thr Gln Pro Thr Arg Asn Gln
                655                 660                 665
Cys Cys Ser Asn
            670

<210> 106
<211> 264
<212> PRT
<213> Artificial Sequence

<220> 
<223> mesothelin specific scFv derived from M912
      antibody

<220>
<221> SIGNAL         
<222> (1)...(22)

<400> 106
Met Leu Leu Leu Val Thr Ser Leu Leu Leu Cys Glu Leu Pro His Pro
        -20                 -15                 -10
Ala Phe Leu Leu Ile Pro Asp Ile Gln Met Thr Gln Ser Pro Ser Ser
    -5                   1               5                  10
Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser
                15                  20                  25
Gln Ser Ile Ser Ser Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys
            30                  35                  40
Ala Pro Lys Leu Leu Ile Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val
        45                  50                  55
Pro Ser Gly Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr
    60                  65                  70
Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln
75                  80                  85                  90
Ser Tyr Ser Thr Pro Leu Thr Phe Gly Gly Gly Thr Lys Val Glu Ile
                95                  100                 105
Lys Arg Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly
            110                 115                 120
Ser Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser
        125                 130                 135
Glu Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Gly Ser Val Ser Ser
    140                 145                 150
Gly Ser Tyr Tyr Trp Ser Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu
155                 160                 165                 170
Glu Trp Ile Gly Tyr Ile Tyr Tyr Ser Gly Ser Thr Asn Tyr Asn Pro
                175                 180                 185
Ser Leu Lys Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln
            190                 195                 200
Phe Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr
        205                 210                 215
Tyr Cys Ala Arg Glu Gly Lys Asn Gly Ala Phe Asp Ile Trp Gly Gln
    220                 225                 230
Gly Thr Met Val Thr Val Ser Ser
235                 240

<210> 107
<211> 452
<212> PRT
<213> Artificial Sequence

<220> 
<223> M912 scFv-IgG4 spacer-Tim4 TM-tMyD88 CER50
      chimeric engulfment receptor

<220>
<221> SIGNAL         
<222> (1)...(22)

<400> 107
Met Leu Leu Leu Val Thr Ser Leu Leu Leu Cys Glu Leu Pro His Pro
        -20                 -15                 -10
Ala Phe Leu Leu Ile Pro Asp Ile Gln Met Thr Gln Ser Pro Ser Ser
    -5                   1               5                  10
Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser
                15                  20                  25
Gln Ser Ile Ser Ser Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys
            30                  35                  40
Ala Pro Lys Leu Leu Ile Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val
        45                  50                  55
Pro Ser Gly Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr
    60                  65                  70
Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln
75                  80                  85                  90
Ser Tyr Ser Thr Pro Leu Thr Phe Gly Gly Gly Thr Lys Val Glu Ile
                95                  100                 105
Lys Arg Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly
            110                 115                 120
Ser Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser
        125                 130                 135
Glu Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Gly Ser Val Ser Ser
    140                 145                 150
Gly Ser Tyr Tyr Trp Ser Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu
155                 160                 165                 170
Glu Trp Ile Gly Tyr Ile Tyr Tyr Ser Gly Ser Thr Asn Tyr Asn Pro
                175                 180                 185
Ser Leu Lys Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln
            190                 195                 200
Phe Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr
        205                 210                 215
Tyr Cys Ala Arg Glu Gly Lys Asn Gly Ala Phe Asp Ile Trp Gly Gln
    220                 225                 230
Gly Thr Met Val Thr Val Ser Ser Glu Ser Lys Tyr Gly Pro Pro Cys
235                 240                 245                 250
Pro Pro Cys Pro Ile Leu Ile Ile Ala Cys Cys Val Gly Phe Val Leu
                255                 260                 265
Met Val Leu Leu Phe Leu Ala Phe Leu Met Ala Ala Gly Gly Pro Gly
            270                 275                 280
Ala Gly Ser Ala Ala Pro Val Ser Ser Thr Ser Ser Leu Pro Leu Ala
        285                 290                 295
Ala Leu Asn Met Arg Val Arg Arg Arg Leu Ser Leu Phe Leu Asn Val
    300                 305                 310
Arg Thr Gln Val Ala Ala Asp Trp Thr Ala Leu Ala Glu Glu Met Asp
315                 320                 325                 330
Phe Glu Tyr Leu Glu Ile Arg Gln Leu Glu Thr Gln Ala Asp Pro Thr
                335                 340                 345
Gly Arg Leu Leu Asp Ala Trp Gln Gly Arg Pro Gly Ala Ser Val Gly
            350                 355                 360
Arg Leu Leu Glu Leu Leu Thr Lys Leu Gly Arg Asp Asp Val Leu Leu
        365                 370                 375
Glu Leu Gly Pro Ser Ile Glu Glu Asp Cys Gln Lys Tyr Ile Leu Lys
    380                 385                 390
Gln Gln Gln Glu Glu Ala Glu Lys Pro Leu Gln Val Ala Ala Val Asp
395                 400                 405                 410
Ser Ser Val Pro Arg Thr Ala Glu Leu Ala Gly Ile Thr Thr Leu Asp
                415                 420                 425
Asp Pro Leu Gly
            430

<210> 108

<400> 108
000


<210> 109

<400> 109
000


<210> 110


<400> 110
000


<210> 111

<400> 111
000


<210> 112

<400> 112
000

<210> 113

<400> 113 
000

<210> 114
<211> 57
<212> PRT
<213> Homo sapiens

<220> 
<223> ItgB5 signaling domain

<400> 114
Lys Leu Leu Val Thr Ile His Asp Arg Arg Glu Phe Ala Lys Phe Gln
 1               5                  10                  15
Ser Glu Arg Ser Arg Ala Arg Tyr Glu Met Ala Ser Asn Pro Leu Tyr
            20                  25                  30
Arg Lys Pro Ile Ser Thr His Thr Val Asp Phe Thr Phe Asn Lys Phe
        35                  40                  45
Asn Lys Ser Tyr Asn Gly Thr Val Asp
    50                  55

<210> 115
<211> 279
<212> PRT
<213> Mus musculus

<220> 
<223> Tim4 binding domain

<220>
<221> SIGNAL         
<222> (1)...(22)

<400> 115
Met Ser Lys Gly Leu Leu Leu Leu Trp Leu Val Thr Glu Leu Trp Trp
        -20                 -15                 -10
Leu Tyr Leu Thr Pro Ala Ala Ser Glu Asp Thr Ile Ile Gly Phe Leu
    -5                   1               5                  10
Gly Gln Pro Val Thr Leu Pro Cys His Tyr Leu Ser Trp Ser Gln Ser
                15                  20                  25
Arg Asn Ser Met Cys Trp Gly Lys Gly Ser Cys Pro Asn Ser Lys Cys
            30                  35                  40
Asn Ala Glu Leu Leu Arg Thr Asp Gly Thr Arg Ile Ile Ser Arg Lys
        45                  50                  55
Ser Thr Lys Tyr Thr Leu Leu Gly Lys Val Gln Phe Gly Glu Val Ser
    60                  65                  70
Leu Thr Ile Ser Asn Thr Asn Arg Gly Asp Ser Gly Val Tyr Cys Cys
75                  80                  85                  90
Arg Ile Glu Val Pro Gly Trp Phe Asn Asp Val Lys Lys Asn Val Arg
                95                  100                 105
Leu Glu Leu Arg Arg Ala Thr Thr Thr Lys Lys Pro Thr Thr Thr Thr
            110                 115                 120
Arg Pro Thr Thr Thr Pro Tyr Val Thr Thr Thr Thr Pro Glu Leu Leu
        125                 130                 135
Pro Thr Thr Val Met Thr Thr Ser Val Leu Pro Thr Thr Thr Pro Pro
    140                 145                 150
Gln Thr Leu Ala Thr Thr Ala Phe Ser Thr Ala Val Thr Thr Cys Pro
155                 160                 165                 170
Ser Thr Thr Pro Gly Ser Phe Ser Gln Glu Thr Thr Lys Gly Ser Ala
                175                 180                 185
Phe Thr Thr Glu Ser Glu Thr Leu Pro Ala Ser Asn His Ser Gln Arg
            190                 195                 200
Ser Met Met Thr Ile Ser Thr Asp Ile Ala Val Leu Arg Pro Thr Gly
        205                 210                 215
Ser Asn Pro Gly Ile Leu Pro Ser Thr Ser Gln Leu Thr Thr Gln Lys
    220                 225                 230
Thr Thr Leu Thr Thr Ser Glu Ser Leu Gln Lys Thr Thr Lys Ser His
235                 240                 245                 250
Gln Ile Asn Ser Arg Gln Thr
                255

<210> 116
<211> 829
<212> PRT
<213> Artificial Sequence

<220> 
<223> CER96 with truncated NFAM1 chimeric engulfment
      receptor

<220>
<221> SIGNAL         
<222> (1)...(22)

<400> 116
Met Ser Lys Gly Leu Leu Leu Leu Trp Leu Val Thr Glu Leu Trp Trp
        -20                 -15                 -10
Leu Tyr Leu Thr Pro Ala Ala Ser Glu Asp Thr Ile Ile Gly Phe Leu
    -5                   1               5                  10
Gly Gln Pro Val Thr Leu Pro Cys His Tyr Leu Ser Trp Ser Gln Ser
                15                  20                  25
Arg Asn Ser Met Cys Trp Gly Lys Gly Ser Cys Pro Asn Ser Lys Cys
            30                  35                  40
Asn Ala Glu Leu Leu Arg Thr Asp Gly Thr Arg Ile Ile Ser Arg Lys
        45                  50                  55
Ser Thr Lys Tyr Thr Leu Leu Gly Lys Val Gln Phe Gly Glu Val Ser
    60                  65                  70
Leu Thr Ile Ser Asn Thr Asn Arg Gly Asp Ser Gly Val Tyr Cys Cys
75                  80                  85                  90
Arg Ile Glu Val Pro Gly Trp Phe Asn Asp Val Lys Lys Asn Val Arg
                95                  100                 105
Leu Glu Leu Arg Arg Ala Thr Thr Thr Lys Lys Pro Thr Thr Thr Thr
            110                 115                 120
Arg Pro Thr Thr Thr Pro Tyr Val Thr Thr Thr Thr Pro Glu Leu Leu
        125                 130                 135
Pro Thr Thr Val Met Thr Thr Ser Val Leu Pro Thr Thr Thr Pro Pro
    140                 145                 150
Gln Thr Leu Ala Thr Thr Ala Phe Ser Thr Ala Val Thr Thr Cys Pro
155                 160                 165                 170
Ser Thr Thr Pro Gly Ser Phe Ser Gln Glu Thr Thr Lys Gly Ser Ala
                175                 180                 185
Phe Thr Thr Glu Ser Glu Thr Leu Pro Ala Ser Asn His Ser Gln Arg
            190                 195                 200
Ser Met Met Thr Ile Ser Thr Asp Ile Ala Val Leu Arg Pro Thr Gly
        205                 210                 215
Ser Asn Pro Gly Ile Leu Pro Ser Thr Ser Gln Leu Thr Thr Gln Lys
    220                 225                 230
Thr Thr Leu Thr Thr Ser Glu Ser Leu Gln Lys Thr Thr Lys Ser His
235                 240                 245                 250
Gln Ile Asn Ser Arg Gln Thr Ile Leu Ile Ile Ala Cys Cys Val Gly
                255                 260                 265
Phe Val Leu Met Val Leu Leu Phe Leu Ala Phe Leu Ala Leu Arg Arg
            270                 275                 280
Arg Val Gln Glu Thr Lys Phe Gly Gly Ala Phe Ser Glu Glu Asp Ser
        285                 290                 295
Gln Leu Val Val Asn Tyr Arg Ala Lys Lys Ser Phe Cys Arg Arg Ala
    300                 305                 310
Ile Glu Leu Thr Leu Gln Ser Leu Gly Val Ser Glu Glu Leu Gln Asn
315                 320                 325                 330
Lys Leu Glu Asp Val Val Ile Asp Arg Asn Leu Leu Val Leu Gly Lys
                335                 340                 345
Val Leu Gly Glu Gly Glu Phe Gly Ser Val Met Glu Gly Asn Leu Lys
            350                 355                 360
Gln Glu Asp Gly Thr Ser Gln Lys Val Ala Val Lys Thr Met Lys Leu
        365                 370                 375
Asp Asn Phe Ser Gln Arg Glu Ile Glu Glu Phe Leu Ser Glu Ala Ala
    380                 385                 390
Cys Met Lys Asp Phe Asn His Pro Asn Val Ile Arg Leu Leu Gly Val
395                 400                 405                 410
Cys Ile Glu Leu Ser Ser Gln Gly Ile Pro Lys Pro Met Val Ile Leu
                415                 420                 425
Pro Phe Met Lys Tyr Gly Asp Leu His Thr Phe Leu Leu Tyr Ser Arg
            430                 435                 440
Leu Asn Thr Gly Pro Lys Tyr Ile His Leu Gln Thr Leu Leu Lys Phe
        445                 450                 455
Met Met Asp Ile Ala Gln Gly Met Glu Tyr Leu Ser Asn Arg Asn Phe
    460                 465                 470
Leu His Arg Asp Leu Ala Ala Arg Asn Cys Met Leu Arg Asp Asp Met
475                 480                 485                 490
Thr Val Cys Val Ala Asp Phe Gly Leu Ser Lys Lys Ile Tyr Ser Gly
                495                 500                 505
Asp Tyr Tyr Arg Gln Gly Arg Ile Ala Lys Met Pro Val Lys Trp Ile
            510                 515                 520
Ala Ile Glu Ser Leu Ala Asp Arg Val Tyr Thr Ser Lys Ser Asp Val
        525                 530                 535
Trp Ala Phe Gly Val Thr Met Trp Glu Ile Thr Thr Arg Gly Met Thr
    540                 545                 550
Pro Tyr Pro Gly Val Gln Asn His Glu Met Tyr Asp Tyr Leu Leu His
555                 560                 565                 570
Gly His Arg Leu Lys Gln Pro Glu Asp Cys Leu Asp Glu Leu Tyr Asp
                575                 580                 585
Ile Met Tyr Ser Cys Trp Ser Ala Asp Pro Leu Asp Arg Pro Thr Phe
            590                 595                 600
Ser Val Leu Arg Leu Gln Leu Glu Lys Leu Ser Glu Ser Leu Pro Asp
        605                 610                 615
Ala Gln Asp Lys Glu Ser Ile Ile Tyr Ile Asn Thr Gln Leu Leu Glu
    620                 625                 630
Ser Cys Glu Gly Ile Ala Asn Gly Pro Ser Leu Thr Gly Leu Asp Met
635                 640                 645                 650
Asn Ile Asp Pro Asp Ser Ile Ile Ala Ser Cys Thr Pro Gly Ala Ala
                655                 660                 665
Val Ser Val Val Thr Ala Glu Val His Glu Asn Asn Leu Arg Glu Glu
            670                 675                 680
Arg Tyr Ile Leu Asn Gly Gly Asn Glu Glu Trp Glu Asp Val Ser Ser
        685                 690                 695
Thr Pro Phe Ala Ala Val Thr Pro Glu Lys Asp Gly Val Leu Pro Glu
    700                 705                 710
Asp Arg Leu Thr Lys Asn Gly Val Ser Trp Ser His His Ser Thr Leu
715                 720                 725                 730
Pro Leu Gly Ser Pro Ser Pro Asp Glu Leu Leu Phe Val Asp Asp Ser
                735                 740                 745
Leu Glu Asp Ser Glu Val Leu Met Leu Trp Asn Lys Lys Arg Met Arg
            750                 755                 760
Gly Pro Gly Lys Asp Pro Thr Arg Lys Cys Pro Asp Pro Arg Ser Ala
        765                 770                 775
Ser Ser Pro Lys Gln His Pro Ser Glu Ser Val Tyr Thr Ala Leu Gln
    780                 785                 790
Arg Arg Glu Thr Glu Val Tyr Ala Cys Ile Glu Asn Glu
795                 800                 805

<210> 117
<211> 918
<212> PRT
<213> Homo sapiens

<220> 
<223> BAI1 binding domain

<400> 117
Ala Ala Gly Ala Asp Ala Gly Pro Gly Pro Glu Pro Cys Ala Thr Leu
 1               5                  10                  15
Val Gln Gly Lys Phe Phe Gly Tyr Phe Ser Ala Ala Ala Val Phe Pro
            20                  25                  30
Ala Asn Ala Ser Arg Cys Ser Trp Thr Leu Arg Asn Pro Asp Pro Arg
        35                  40                  45
Arg Tyr Thr Leu Tyr Met Lys Val Ala Lys Ala Pro Val Pro Cys Ser
    50                  55                  60
Gly Pro Gly Arg Val Arg Thr Tyr Gln Phe Asp Ser Phe Leu Glu Ser
65                  70                  75                  80
Thr Arg Thr Tyr Leu Gly Val Glu Ser Phe Asp Glu Val Leu Arg Leu
                85                  90                  95
Cys Asp Pro Ser Ala Pro Leu Ala Phe Leu Gln Ala Ser Lys Gln Phe
            100                 105                 110
Leu Gln Met Arg Arg Gln Gln Pro Pro Gln His Asp Gly Leu Arg Pro
        115                 120                 125
Arg Ala Gly Pro Pro Gly Pro Thr Asp Asp Phe Ser Val Glu Tyr Leu
    130                 135                 140
Val Val Gly Asn Arg Asn Pro Ser Arg Ala Ala Cys Gln Met Leu Cys
145                 150                 155                 160
Arg Trp Leu Asp Ala Cys Leu Ala Gly Ser Arg Ser Ser His Pro Cys
                165                 170                 175
Gly Ile Met Gln Thr Pro Cys Ala Cys Leu Gly Gly Glu Ala Gly Gly
            180                 185                 190
Pro Ala Ala Gly Pro Leu Ala Pro Arg Gly Asp Val Cys Leu Arg Asp
        195                 200                 205
Ala Val Ala Gly Gly Pro Glu Asn Cys Leu Thr Ser Leu Thr Gln Asp
    210                 215                 220
Arg Gly Gly His Gly Ala Thr Gly Gly Trp Lys Leu Trp Ser Leu Trp
225                 230                 235                 240
Gly Glu Cys Thr Arg Asp Cys Gly Gly Gly Leu Gln Thr Arg Thr Arg
                245                 250                 255
Thr Cys Leu Pro Ala Pro Gly Val Glu Gly Gly Gly Cys Glu Gly Val
            260                 265                 270
Leu Glu Glu Gly Arg Gln Cys Asn Arg Glu Ala Cys Gly Pro Ala Gly
        275                 280                 285
Arg Thr Ser Ser Arg Ser Gln Ser Leu Arg Ser Thr Asp Ala Arg Arg
    290                 295                 300
Arg Glu Glu Leu Gly Asp Glu Leu Gln Gln Phe Gly Phe Pro Ala Pro
305                 310                 315                 320
Gln Thr Gly Asp Pro Ala Ala Glu Glu Trp Ser Pro Trp Ser Val Cys
                325                 330                 335
Ser Ser Thr Cys Gly Glu Gly Trp Gln Thr Arg Thr Arg Phe Cys Val
            340                 345                 350
Ser Ser Ser Tyr Ser Thr Gln Cys Ser Gly Pro Leu Arg Glu Gln Arg
        355                 360                 365
Leu Cys Asn Asn Ser Ala Val Cys Pro Val His Gly Ala Trp Asp Glu
    370                 375                 380
Trp Ser Pro Trp Ser Leu Cys Ser Ser Thr Cys Gly Arg Gly Phe Arg
385                 390                 395                 400
Asp Arg Thr Arg Thr Cys Arg Pro Pro Gln Phe Gly Gly Asn Pro Cys
                405                 410                 415
Glu Gly Pro Glu Lys Gln Thr Lys Phe Cys Asn Ile Ala Leu Cys Pro
            420                 425                 430
Gly Arg Ala Val Asp Gly Asn Trp Asn Glu Trp Ser Ser Trp Ser Ala
        435                 440                 445
Cys Ser Ala Ser Cys Ser Gln Gly Arg Gln Gln Arg Thr Arg Glu Cys
    450                 455                 460
Asn Gly Pro Ser Tyr Gly Gly Ala Glu Cys Gln Gly His Trp Val Glu
465                 470                 475                 480
Thr Arg Asp Cys Phe Leu Gln Gln Cys Pro Val Asp Gly Lys Trp Gln
                485                 490                 495
Ala Trp Ala Ser Trp Gly Ser Cys Ser Val Thr Cys Gly Ala Gly Ser
            500                 505                 510
Gln Arg Arg Glu Arg Val Cys Ser Gly Pro Phe Phe Gly Gly Ala Ala
        515                 520                 525
Cys Gln Gly Pro Gln Asp Glu Tyr Arg Gln Cys Gly Thr Gln Arg Cys
    530                 535                 540
Pro Glu Pro His Glu Ile Cys Asp Glu Asp Asn Phe Gly Ala Val Ile
545                 550                 555                 560
Trp Lys Glu Thr Pro Ala Gly Glu Val Ala Ala Val Arg Cys Pro Arg
                565                 570                 575
Asn Ala Thr Gly Leu Ile Leu Arg Arg Cys Glu Leu Asp Glu Glu Gly
            580                 585                 590
Ile Ala Tyr Trp Glu Pro Pro Thr Tyr Ile Arg Cys Val Ser Ile Asp
        595                 600                 605
Tyr Arg Asn Ile Gln Met Met Thr Arg Glu His Leu Ala Lys Ala Gln
    610                 615                 620
Arg Gly Leu Pro Gly Glu Gly Val Ser Glu Val Ile Gln Thr Leu Val
625                 630                 635                 640
Glu Ile Ser Gln Asp Gly Thr Ser Tyr Ser Gly Asp Leu Leu Ser Thr
                645                 650                 655
Ile Asp Val Leu Arg Asn Met Thr Glu Ile Phe Arg Arg Ala Tyr Tyr
            660                 665                 670
Ser Pro Thr Pro Gly Asp Val Gln Asn Phe Val Gln Ile Leu Ser Asn
        675                 680                 685
Leu Leu Ala Glu Glu Asn Arg Asp Lys Trp Glu Glu Ala Gln Leu Ala
    690                 695                 700
Gly Pro Asn Ala Lys Glu Leu Phe Arg Leu Val Glu Asp Phe Val Asp
705                 710                 715                 720
Val Ile Gly Phe Arg Met Lys Asp Leu Arg Asp Ala Tyr Gln Val Thr
                725                 730                 735
Asp Asn Leu Val Leu Ser Ile His Lys Leu Pro Ala Ser Gly Ala Thr
            740                 745                 750
Asp Ile Ser Phe Pro Met Lys Gly Trp Arg Ala Thr Gly Asp Trp Ala
        755                 760                 765
Lys Val Pro Glu Asp Arg Val Thr Val Ser Lys Ser Val Phe Ser Thr
    770                 775                 780
Gly Leu Thr Glu Ala Asp Glu Ala Ser Val Phe Val Val Gly Thr Val
785                 790                 795                 800
Leu Tyr Arg Asn Leu Gly Ser Phe Leu Ala Leu Gln Arg Asn Thr Thr
                805                 810                 815
Val Leu Asn Ser Lys Val Ile Ser Val Thr Val Lys Pro Pro Pro Arg
            820                 825                 830
Ser Leu Arg Thr Pro Leu Glu Ile Glu Phe Ala His Met Tyr Asn Gly
        835                 840                 845
Thr Thr Asn Gln Thr Cys Ile Leu Trp Asp Glu Thr Asp Val Pro Ser
    850                 855                 860
Ser Ser Ala Pro Pro Gln Leu Gly Pro Trp Ser Trp Arg Gly Cys Arg
865                 870                 875                 880
Thr Val Pro Leu Asp Ala Leu Arg Thr Arg Cys Leu Cys Asp Arg Leu
                885                 890                 895
Ser Thr Phe Ala Ile Leu Ala Gln Leu Ser Ala Asp Ala Asn Met Glu
            900                 905                 910
Lys Ala Thr Leu Pro Ser
        915

<210> 118
<211> 21
<212> PRT
<213> Homo sapiens

<220> 
<223> MRC1 transmembrane domain

<400> 118
Gly Val Val Ile Ile Val Ile Leu Leu Ile Leu Thr Gly Ala Gly Leu
 1               5                  10                  15
Ala Ala Tyr Phe Phe
            20

<210> 119
<211> 46
<212> PRT
<213> Homo sapiens

<220> 
<223> MRC1 signaling domain

<400> 119
Tyr Lys Lys Arg Arg Val His Leu Pro Gln Glu Gly Ala Phe Glu Asn
 1               5                  10                  15
Thr Leu Tyr Phe Asn Ser Gln Ser Ser Pro Gly Thr Ser Asp Met Lys
            20                  25                  30
Asp Leu Val Gly Asn Ile Glu Gln Asn Glu His Ser Val Ile
        35                  40                  45

<210> 120
<211> 727
<212> PRT
<213> Homo sapiens

<220> 
<223> ELMO

<400> 120
Met Pro Pro Pro Ala Asp Ile Val Lys Val Ala Ile Glu Trp Pro Gly
 1               5                  10                  15
Ala Tyr Pro Lys Leu Met Glu Ile Asp Gln Lys Lys Pro Leu Ser Ala
            20                  25                  30
Ile Ile Lys Glu Val Cys Asp Gly Trp Ser Leu Ala Asn His Glu Tyr
        35                  40                  45
Phe Ala Leu Gln His Ala Asp Ser Ser Asn Phe Tyr Ile Thr Glu Lys
    50                  55                  60
Asn Arg Asn Glu Ile Lys Asn Gly Thr Ile Leu Arg Leu Thr Thr Ser
65                  70                  75                  80
Pro Ala Gln Asn Ala Gln Gln Leu His Glu Arg Ile Gln Ser Ser Ser
                85                  90                  95
Met Asp Ala Lys Leu Glu Ala Leu Lys Asp Leu Ala Ser Leu Ser Arg
            100                 105                 110
Asp Val Thr Phe Ala Gln Glu Phe Ile Asn Leu Asp Gly Ile Ser Leu
        115                 120                 125
Leu Thr Gln Met Val Glu Ser Gly Thr Glu Arg Tyr Gln Lys Leu Gln
    130                 135                 140
Lys Ile Met Lys Pro Cys Phe Gly Asp Met Leu Ser Phe Thr Leu Thr
145                 150                 155                 160
Ala Phe Val Glu Leu Met Asp His Gly Ile Val Ser Trp Asp Thr Phe
                165                 170                 175
Ser Val Ala Phe Ile Lys Lys Ile Ala Ser Phe Val Asn Lys Ser Ala
            180                 185                 190
Ile Asp Ile Ser Ile Leu Gln Arg Ser Leu Ala Ile Leu Glu Ser Met
        195                 200                 205
Val Leu Asn Ser His Asp Leu Tyr Gln Lys Val Ala Gln Glu Ile Thr
    210                 215                 220
Ile Gly Gln Leu Ile Pro His Leu Gln Gly Ser Asp Gln Glu Ile Gln
225                 230                 235                 240
Thr Tyr Thr Ile Ala Val Ile Asn Ala Leu Phe Leu Lys Ala Pro Asp
                245                 250                 255
Glu Arg Arg Gln Glu Met Ala Asn Ile Leu Ala Gln Lys Gln Leu Arg
            260                 265                 270
Ser Ile Ile Leu Thr His Val Ile Arg Ala Gln Arg Ala Ile Asn Asn
        275                 280                 285
Glu Met Ala His Gln Leu Tyr Val Leu Gln Val Leu Thr Phe Asn Leu
    290                 295                 300
Leu Glu Asp Arg Met Met Thr Lys Met Asp Pro Gln Asp Gln Ala Gln
305                 310                 315                 320
Arg Asp Ile Ile Phe Glu Leu Arg Arg Ile Ala Phe Asp Ala Glu Ser
                325                 330                 335
Glu Pro Asn Asn Ser Ser Gly Ser Met Glu Lys Arg Lys Ser Met Tyr
            340                 345                 350
Thr Arg Asp Tyr Lys Lys Leu Gly Phe Ile Asn His Val Asn Pro Ala
        355                 360                 365
Met Asp Phe Thr Gln Thr Pro Pro Gly Met Leu Ala Leu Asp Asn Met
    370                 375                 380
Leu Tyr Phe Ala Lys His His Gln Asp Ala Tyr Ile Arg Ile Val Leu
385                 390                 395                 400
Glu Asn Ser Ser Arg Glu Asp Lys His Glu Cys Pro Phe Gly Arg Ser
                405                 410                 415
Ser Ile Glu Leu Thr Lys Met Leu Cys Glu Ile Leu Lys Val Gly Glu
            420                 425                 430
Leu Pro Ser Glu Thr Cys Asn Asp Phe His Pro Met Phe Phe Thr His
        435                 440                 445
Asp Arg Ser Phe Glu Glu Phe Phe Cys Ile Cys Ile Gln Leu Leu Asn
    450                 455                 460
Lys Thr Trp Lys Glu Met Arg Ala Thr Ser Glu Asp Phe Asn Lys Val
465                 470                 475                 480
Met Gln Val Val Lys Glu Gln Val Met Arg Ala Leu Thr Thr Lys Pro
                485                 490                 495
Ser Ser Leu Asp Gln Phe Lys Ser Lys Leu Gln Asn Leu Ser Tyr Thr
            500                 505                 510
Glu Ile Leu Lys Ile Arg Gln Ser Glu Arg Met Asn Gln Glu Asp Phe
        515                 520                 525
Gln Ser Arg Pro Ile Leu Glu Leu Lys Glu Lys Ile Gln Pro Glu Ile
    530                 535                 540
Leu Glu Leu Ile Lys Gln Gln Arg Leu Asn Arg Leu Val Glu Gly Thr
545                 550                 555                 560
Cys Phe Arg Lys Leu Asn Ala Arg Arg Arg Gln Asp Lys Phe Trp Tyr
                565                 570                 575
Cys Arg Leu Ser Pro Asn His Lys Val Leu His Tyr Gly Asp Leu Glu
            580                 585                 590
Glu Ser Pro Gln Gly Glu Val Pro His Asp Ser Leu Gln Asp Lys Leu
        595                 600                 605
Pro Val Ala Asp Ile Lys Ala Val Val Thr Gly Lys Asp Cys Pro His
    610                 615                 620
Met Lys Glu Lys Gly Ala Leu Lys Gln Asn Lys Glu Val Leu Glu Leu
625                 630                 635                 640
Ala Phe Ser Ile Leu Tyr Asp Ser Asn Cys Gln Leu Asn Phe Ile Ala
                645                 650                 655
Pro Asp Lys His Glu Tyr Cys Ile Trp Thr Asp Gly Leu Asn Ala Leu
            660                 665                 670
Leu Gly Lys Asp Met Met Ser Asp Leu Thr Arg Asn Asp Leu Asp Thr
        675                 680                 685
Leu Leu Ser Met Glu Ile Lys Leu Arg Leu Leu Asp Leu Glu Asn Ile
    690                 695                 700
Gln Ile Pro Asp Ala Pro Pro Pro Ile Pro Lys Glu Pro Ser Asn Tyr
705                 710                 715                 720
Asp Phe Val Tyr Asp Cys Asn
                725

<210> 121
<211> 285
<212> PRT
<213> Homo sapiens

<220> 
<223> truncated EGFR

<400> 121
Arg Lys Val Cys Asn Gly Ile Gly Ile Gly Glu Phe Lys Asp Ser Leu
 1               5                  10                  15
Ser Ile Asn Ala Thr Asn Ile Lys His Phe Lys Asn Cys Thr Ser Ile
            20                  25                  30
Ser Gly Asp Leu His Ile Leu Pro Val Ala Phe Arg Gly Asp Ser Phe
        35                  40                  45
Thr His Thr Pro Pro Leu Asp Pro Gln Glu Leu Asp Ile Leu Lys Thr
    50                  55                  60
Val Lys Glu Ile Thr Gly Phe Leu Leu Ile Gln Ala Trp Pro Glu Asn
65                  70                  75                  80
Arg Thr Asp Leu His Ala Phe Glu Asn Leu Glu Ile Ile Arg Gly Arg
                85                  90                  95
Thr Lys Gln His Gly Gln Phe Ser Leu Ala Val Val Ser Leu Asn Ile
            100                 105                 110
Thr Ser Leu Gly Leu Arg Ser Leu Lys Glu Ile Ser Asp Gly Asp Val
        115                 120                 125
Ile Ile Ser Gly Asn Lys Asn Leu Cys Tyr Ala Asn Thr Ile Asn Trp
    130                 135                 140
Lys Lys Leu Phe Gly Thr Ser Gly Gln Lys Thr Lys Ile Ile Ser Asn
145                 150                 155                 160
Arg Gly Glu Asn Ser Cys Lys Ala Thr Gly Gln Val Cys His Ala Leu
                165                 170                 175
Cys Ser Pro Glu Gly Cys Trp Gly Pro Glu Pro Arg Asp Cys Val Ser
            180                 185                 190
Cys Arg Asn Val Ser Arg Gly Arg Glu Cys Val Asp Lys Cys Asn Leu
        195                 200                 205
Leu Glu Gly Glu Pro Arg Glu Phe Val Glu Asn Ser Glu Cys Ile Gln
    210                 215                 220
Cys His Pro Glu Cys Leu Pro Gln Ala Met Asn Ile Thr Cys Thr Gly
225                 230                 235                 240
Arg Gly Pro Asp Asn Cys Ile Gln Cys Ala His Tyr Ile Asp Gly Pro
                245                 250                 255
His Cys Val Lys Thr Cys Pro Ala Gly Val Met Gly Glu Asn Asn Thr
            260                 265                 270
Leu Val Trp Lys Tyr Ala Asp Ala Gly His Val Cys His
        275                 280                 285

<210> 122
<211> 207
<212> PRT
<213> Homo sapiens

<220> 
<223> Rab7

<400> 122
Met Thr Ser Arg Lys Lys Val Leu Leu Lys Val Ile Ile Leu Gly Asp
 1               5                  10                  15
Ser Gly Val Gly Lys Thr Ser Leu Met Asn Gln Tyr Val Asn Lys Lys
            20                  25                  30
Phe Ser Asn Gln Tyr Lys Ala Thr Ile Gly Ala Asp Phe Leu Thr Lys
        35                  40                  45
Glu Val Met Val Asp Asp Arg Leu Val Thr Met Gln Ile Trp Asp Thr
    50                  55                  60
Ala Gly Gln Glu Arg Phe Gln Ser Leu Gly Val Ala Phe Tyr Arg Gly
65                  70                  75                  80
Ala Asp Cys Cys Val Leu Val Phe Asp Val Thr Ala Pro Asn Thr Phe
                85                  90                  95
Lys Thr Leu Asp Ser Trp Arg Asp Glu Phe Leu Ile Gln Ala Ser Pro
            100                 105                 110
Arg Asp Pro Glu Asn Phe Pro Phe Val Val Leu Gly Asn Lys Ile Asp
        115                 120                 125
Leu Glu Asn Arg Gln Val Ala Thr Lys Arg Ala Gln Ala Trp Cys Tyr
    130                 135                 140
Ser Lys Asn Asn Ile Pro Tyr Phe Glu Thr Ser Ala Lys Glu Ala Ile
145                 150                 155                 160
Asn Val Glu Gln Ala Phe Gln Thr Ile Ala Arg Asn Ala Leu Lys Gln
                165                 170                 175
Glu Thr Glu Val Glu Leu Tyr Asn Glu Phe Pro Glu Pro Ile Lys Leu
            180                 185                 190
Asp Lys Asn Asp Arg Ala Lys Ala Ser Ala Glu Ser Cys Ser Cys
        195                 200                 205

<210> 123
<211> 184
<212> PRT
<213> Homo sapiens

<220> 
<223> Rap1A

<400> 123
Met Arg Glu Tyr Lys Leu Val Val Leu Gly Ser Gly Gly Val Gly Lys
 1               5                  10                  15
Ser Ala Leu Thr Val Gln Phe Val Gln Gly Ile Phe Val Glu Lys Tyr
            20                  25                  30
Asp Pro Thr Ile Glu Asp Ser Tyr Arg Lys Gln Val Glu Val Asp Cys
        35                  40                  45
Gln Gln Cys Met Leu Glu Ile Leu Asp Thr Ala Gly Thr Glu Gln Phe
    50                  55                  60
Thr Ala Met Arg Asp Leu Tyr Met Lys Asn Gly Gln Gly Phe Ala Leu
65                  70                  75                  80
Val Tyr Ser Ile Thr Ala Gln Ser Thr Phe Asn Asp Leu Gln Asp Leu
                85                  90                  95
Arg Glu Gln Ile Leu Arg Val Lys Asp Thr Glu Asp Val Pro Met Ile
            100                 105                 110
Leu Val Gly Asn Lys Cys Asp Leu Glu Asp Glu Arg Val Val Gly Lys
        115                 120                 125
Glu Gln Gly Gln Asn Leu Ala Arg Gln Trp Cys Asn Cys Ala Phe Leu
    130                 135                 140
Glu Ser Ser Ala Lys Ser Lys Ile Asn Val Asn Glu Ile Phe Tyr Asp
145                 150                 155                 160
Leu Val Arg Gln Ile Asn Arg Lys Thr Pro Val Glu Lys Lys Lys Pro
                165                 170                 175
Lys Lys Lys Ser Cys Leu Leu Leu
            180

<210> 124
<211> 193
<212> PRT
<213> Homo sapiens

<220> 
<223> RhoA

<400> 124
Met Ala Ala Ile Arg Lys Lys Leu Val Ile Val Gly Asp Gly Ala Cys
 1               5                  10                  15
Gly Lys Thr Cys Leu Leu Ile Val Phe Ser Lys Asp Gln Phe Pro Glu
            20                  25                  30
Val Tyr Val Pro Thr Val Phe Glu Asn Tyr Val Ala Asp Ile Glu Val
        35                  40                  45
Asp Gly Lys Gln Val Glu Leu Ala Leu Trp Asp Thr Ala Gly Gln Glu
    50                  55                  60
Asp Tyr Asp Arg Leu Arg Pro Leu Ser Tyr Pro Asp Thr Asp Val Ile
65                  70                  75                  80
Leu Met Cys Phe Ser Ile Asp Ser Pro Asp Ser Leu Glu Asn Ile Pro
                85                  90                  95
Glu Lys Trp Thr Pro Glu Val Lys His Phe Cys Pro Asn Val Pro Ile
            100                 105                 110
Ile Leu Val Gly Asn Lys Lys Asp Leu Arg Asn Asp Glu His Thr Arg
        115                 120                 125
Arg Glu Leu Ala Lys Met Lys Gln Glu Pro Val Lys Pro Glu Glu Gly
    130                 135                 140
Arg Asp Met Ala Asn Arg Ile Gly Ala Phe Gly Tyr Met Glu Cys Ser
145                 150                 155                 160
Ala Lys Thr Lys Asp Gly Val Arg Glu Val Phe Glu Met Ala Thr Arg
                165                 170                 175
Ala Ala Leu Gln Ala Arg Arg Gly Lys Lys Lys Ser Gly Cys Leu Val
            180                 185                 190
Leu


<210> 125
<211> 191
<212> PRT
<213> Homo sapiens

<220> 
<223> CDC42

<400> 125
Met Gln Thr Ile Lys Cys Val Val Val Gly Asp Gly Ala Val Gly Lys
 1               5                  10                  15
Thr Cys Leu Leu Ile Ser Tyr Thr Thr Asn Lys Phe Pro Ser Glu Tyr
            20                  25                  30
Val Pro Thr Val Phe Asp Asn Tyr Ala Val Thr Val Met Ile Gly Gly
        35                  40                  45
Glu Pro Tyr Thr Leu Gly Leu Phe Asp Thr Ala Gly Gln Glu Asp Tyr
    50                  55                  60
Asp Arg Leu Arg Pro Leu Ser Tyr Pro Gln Thr Asp Val Phe Leu Val
65                  70                  75                  80
Cys Phe Ser Val Val Ser Pro Ser Ser Phe Glu Asn Val Lys Glu Lys
                85                  90                  95
Trp Val Pro Glu Ile Thr His His Cys Pro Lys Thr Pro Phe Leu Leu
            100                 105                 110
Val Gly Thr Gln Ile Asp Leu Arg Asp Asp Pro Ser Thr Ile Glu Lys
        115                 120                 125
Leu Ala Lys Asn Lys Gln Lys Pro Ile Thr Pro Glu Thr Ala Glu Lys
    130                 135                 140
Leu Ala Arg Asp Leu Lys Ala Val Lys Tyr Val Glu Cys Ser Ala Leu
145                 150                 155                 160
Thr Gln Lys Gly Leu Lys Asn Val Phe Asp Glu Ala Ile Leu Ala Ala
                165                 170                 175
Leu Glu Pro Pro Glu Pro Lys Lys Ser Arg Arg Cys Val Leu Leu
            180                 185                 190

<210> 126
<211> 255
<212> DNA
<213> Homo sapiens

<220> 
<223> BAFFR signaling domain

<400> 126
tcctggagac ggcgacaaag gcgcttgcgc ggcgcatcat ccgcagaggc gcccgacggc      60
gataaggacg cgcccgaacc ccttgataaa gttattatct tgtcaccggg aatttctgac     120
gctacggcac ccgcgtggcc tcctccgggc gaagatcctg gtacgacacc ccctggacac     180
agtgttcccg tgcccgcgac agagctcggt agcacagaac tggtgaccac aaagacggcg     240
ggaccggaac agcaa                                                      255

<210> 127
<211> 156
<212> DNA
<213> Homo sapiens

<220> 
<223> DAP12 signaling domain

<400> 127
tattttctgg gaaggctcgt tcctagaggt agaggtgctg ccgaagcagc gacgcgcaaa      60
cagaggatta ctgaaacgga gtctccctac caagagctgc aaggccagag gtcagatgtc     120
tattcagact tgaacacaca aaggccatac tacaaa                               156

<210> 128
<211> 135
<212> DNA
<213> Homo sapiens

<220> 
<223> CD79b signaling domain

<400> 128
gacagtaaag ccgggatgga agaggaccac acatacgagg ggcttgacat agatcaaaca      60
gcgacatacg aagacatcgt aaccttgcgg actggagagg ttaaatggtc agtcggagaa     120
caccccggcc aagaa                                                      135

<210> 129
<211> 258
<212> DNA
<213> Homo sapiens

<220> 
<223> NFAM1 signaling domain

<400> 129
ctctggaata aaaagaggat gcgcggcccg ggaaaagacc caacgagaaa gtgtcccgat      60
ccccgcagtg cgtcaagccc caagcagcat ccttccgaaa gcgtatatac ggcacttcaa     120
cgccgggaaa cggaggtata tgcgtgtatt gagaacgagg acgggtcatc cccgaccgcc     180
aaacagtccc ctctcagcca agagcgacct cacaggtttg aggacgatgg tgaactcaat     240
ctggtctacg aaaacctg                                                   258

<210> 130
<211> 540
<212> PRT
<213> Artificial Sequence

<220> 
<223> Tim4-BAFFR-tMyD88 CER87 chimeric engulfment
      receptor

<220>
<221> SIGNAL         
<222> (1)...(22)

<400> 130
Met Ser Lys Gly Leu Leu Leu Leu Trp Leu Val Thr Glu Leu Trp Trp
        -20                 -15                 -10
Leu Tyr Leu Thr Pro Ala Ala Ser Glu Asp Thr Ile Ile Gly Phe Leu
    -5                   1               5                  10
Gly Gln Pro Val Thr Leu Pro Cys His Tyr Leu Ser Trp Ser Gln Ser
                15                  20                  25
Arg Asn Ser Met Cys Trp Gly Lys Gly Ser Cys Pro Asn Ser Lys Cys
            30                  35                  40
Asn Ala Glu Leu Leu Arg Thr Asp Gly Thr Arg Ile Ile Ser Arg Lys
        45                  50                  55
Ser Thr Lys Tyr Thr Leu Leu Gly Lys Val Gln Phe Gly Glu Val Ser
    60                  65                  70
Leu Thr Ile Ser Asn Thr Asn Arg Gly Asp Ser Gly Val Tyr Cys Cys
75                  80                  85                  90
Arg Ile Glu Val Pro Gly Trp Phe Asn Asp Val Lys Lys Asn Val Arg
                95                  100                 105
Leu Glu Leu Arg Arg Ala Thr Thr Thr Lys Lys Pro Thr Thr Thr Thr
            110                 115                 120
Arg Pro Thr Thr Thr Pro Tyr Val Thr Thr Thr Thr Pro Glu Leu Leu
        125                 130                 135
Pro Thr Thr Val Met Thr Thr Ser Val Leu Pro Thr Thr Thr Pro Pro
    140                 145                 150
Gln Thr Leu Ala Thr Thr Ala Phe Ser Thr Ala Val Thr Thr Cys Pro
155                 160                 165                 170
Ser Thr Thr Pro Gly Ser Phe Ser Gln Glu Thr Thr Lys Gly Ser Ala
                175                 180                 185
Phe Thr Thr Glu Ser Glu Thr Leu Pro Ala Ser Asn His Ser Gln Arg
            190                 195                 200
Ser Met Met Thr Ile Ser Thr Asp Ile Ala Val Leu Arg Pro Thr Gly
        205                 210                 215
Ser Asn Pro Gly Ile Leu Pro Ser Thr Ser Gln Leu Thr Thr Gln Lys
    220                 225                 230
Thr Thr Leu Thr Thr Ser Glu Ser Leu Gln Lys Thr Thr Lys Ser His
235                 240                 245                 250
Gln Ile Asn Ser Arg Gln Thr Ile Leu Ile Ile Ala Cys Cys Val Gly
                255                 260                 265
Phe Val Leu Met Val Leu Leu Phe Leu Ala Phe Leu Ser Trp Arg Arg
            270                 275                 280
Arg Gln Arg Arg Leu Arg Gly Ala Ser Ser Ala Glu Ala Pro Asp Gly
        285                 290                 295
Asp Lys Asp Ala Pro Glu Pro Leu Asp Lys Val Ile Ile Leu Ser Pro
    300                 305                 310
Gly Ile Ser Asp Ala Thr Ala Pro Ala Trp Pro Pro Pro Gly Glu Asp
315                 320                 325                 330
Pro Gly Thr Thr Pro Pro Gly His Ser Val Pro Val Pro Ala Thr Glu
                335                 340                 345
Leu Gly Ser Thr Glu Leu Val Thr Thr Lys Thr Ala Gly Pro Glu Gln
            350                 355                 360
Gln Met Ala Ala Gly Gly Pro Gly Ala Gly Ser Ala Ala Pro Val Ser
        365                 370                 375
Ser Thr Ser Ser Leu Pro Leu Ala Ala Leu Asn Met Arg Val Arg Arg
    380                 385                 390
Arg Leu Ser Leu Phe Leu Asn Val Arg Thr Gln Val Ala Ala Asp Trp
395                 400                 405                 410
Thr Ala Leu Ala Glu Glu Met Asp Phe Glu Tyr Leu Glu Ile Arg Gln
                415                 420                 425
Leu Glu Thr Gln Ala Asp Pro Thr Gly Arg Leu Leu Asp Ala Trp Gln
            430                 435                 440
Gly Arg Pro Gly Ala Ser Val Gly Arg Leu Leu Glu Leu Leu Thr Lys
        445                 450                 455
Leu Gly Arg Asp Asp Val Leu Leu Glu Leu Gly Pro Ser Ile Glu Glu
    460                 465                 470
Asp Cys Gln Lys Tyr Ile Leu Lys Gln Gln Gln Glu Glu Ala Glu Lys
475                 480                 485                 490
Pro Leu Gln Val Ala Ala Val Asp Ser Ser Val Pro Arg Thr Ala Glu
                495                 500                 505
Leu Ala Gly Ile Thr Thr Leu Asp Asp Pro Leu Gly
            510                 515

<210> 131
<211> 507
<212> PRT
<213> Artificial Sequence

<220> 
<223> Tim4-DAP12-tMyD88 CER88 chimeric engulfment
      receptor

<220>
<221> SIGNAL         
<222> (1)...(22)

<400> 131
Met Ser Lys Gly Leu Leu Leu Leu Trp Leu Val Thr Glu Leu Trp Trp
        -20                 -15                 -10
Leu Tyr Leu Thr Pro Ala Ala Ser Glu Asp Thr Ile Ile Gly Phe Leu
    -5                   1               5                  10
Gly Gln Pro Val Thr Leu Pro Cys His Tyr Leu Ser Trp Ser Gln Ser
                15                  20                  25
Arg Asn Ser Met Cys Trp Gly Lys Gly Ser Cys Pro Asn Ser Lys Cys
            30                  35                  40
Asn Ala Glu Leu Leu Arg Thr Asp Gly Thr Arg Ile Ile Ser Arg Lys
        45                  50                  55
Ser Thr Lys Tyr Thr Leu Leu Gly Lys Val Gln Phe Gly Glu Val Ser
    60                  65                  70
Leu Thr Ile Ser Asn Thr Asn Arg Gly Asp Ser Gly Val Tyr Cys Cys
75                  80                  85                  90
Arg Ile Glu Val Pro Gly Trp Phe Asn Asp Val Lys Lys Asn Val Arg
                95                  100                 105
Leu Glu Leu Arg Arg Ala Thr Thr Thr Lys Lys Pro Thr Thr Thr Thr
            110                 115                 120
Arg Pro Thr Thr Thr Pro Tyr Val Thr Thr Thr Thr Pro Glu Leu Leu
        125                 130                 135
Pro Thr Thr Val Met Thr Thr Ser Val Leu Pro Thr Thr Thr Pro Pro
    140                 145                 150
Gln Thr Leu Ala Thr Thr Ala Phe Ser Thr Ala Val Thr Thr Cys Pro
155                 160                 165                 170
Ser Thr Thr Pro Gly Ser Phe Ser Gln Glu Thr Thr Lys Gly Ser Ala
                175                 180                 185
Phe Thr Thr Glu Ser Glu Thr Leu Pro Ala Ser Asn His Ser Gln Arg
            190                 195                 200
Ser Met Met Thr Ile Ser Thr Asp Ile Ala Val Leu Arg Pro Thr Gly
        205                 210                 215
Ser Asn Pro Gly Ile Leu Pro Ser Thr Ser Gln Leu Thr Thr Gln Lys
    220                 225                 230
Thr Thr Leu Thr Thr Ser Glu Ser Leu Gln Lys Thr Thr Lys Ser His
235                 240                 245                 250
Gln Ile Asn Ser Arg Gln Thr Ile Leu Ile Ile Ala Cys Cys Val Gly
                255                 260                 265
Phe Val Leu Met Val Leu Leu Phe Leu Ala Phe Leu Tyr Phe Leu Gly
            270                 275                 280
Arg Leu Val Pro Arg Gly Arg Gly Ala Ala Glu Ala Ala Thr Arg Lys
        285                 290                 295
Gln Arg Ile Thr Glu Thr Glu Ser Pro Tyr Gln Glu Leu Gln Gly Gln
    300                 305                 310
Arg Ser Asp Val Tyr Ser Asp Leu Asn Thr Gln Arg Pro Tyr Tyr Lys
315                 320                 325                 330
Met Ala Ala Gly Gly Pro Gly Ala Gly Ser Ala Ala Pro Val Ser Ser
                335                 340                 345
Thr Ser Ser Leu Pro Leu Ala Ala Leu Asn Met Arg Val Arg Arg Arg
            350                 355                 360
Leu Ser Leu Phe Leu Asn Val Arg Thr Gln Val Ala Ala Asp Trp Thr
        365                 370                 375
Ala Leu Ala Glu Glu Met Asp Phe Glu Tyr Leu Glu Ile Arg Gln Leu
    380                 385                 390
Glu Thr Gln Ala Asp Pro Thr Gly Arg Leu Leu Asp Ala Trp Gln Gly
395                 400                 405                 410
Arg Pro Gly Ala Ser Val Gly Arg Leu Leu Glu Leu Leu Thr Lys Leu
                415                 420                 425
Gly Arg Asp Asp Val Leu Leu Glu Leu Gly Pro Ser Ile Glu Glu Asp
            430                 435                 440
Cys Gln Lys Tyr Ile Leu Lys Gln Gln Gln Glu Glu Ala Glu Lys Pro
        445                 450                 455
Leu Gln Val Ala Ala Val Asp Ser Ser Val Pro Arg Thr Ala Glu Leu
    460                 465                 470
Ala Gly Ile Thr Thr Leu Asp Asp Pro Leu Gly
475                 480                 485

<210> 132
<211> 53
<212> PRT
<213> Homo sapiens

<220> 
<223> truncated NFAM1 signaling domain

<400> 132
Leu Trp Asn Lys Lys Arg Met Arg Gly Pro Gly Lys Asp Pro Thr Arg
 1               5                  10                  15
Lys Cys Pro Asp Pro Arg Ser Ala Ser Ser Pro Lys Gln His Pro Ser
            20                  25                  30
Glu Ser Val Tyr Thr Ala Leu Gln Arg Arg Glu Thr Glu Val Tyr Ala
        35                  40                  45
Cys Ile Glu Asn Glu
    50

<210> 133
<211> 931
<212> PRT
<213> Artificial Sequence

<220> 
<223> TIM4-MERTK-tMYD88 CER92 chimeric engulfment
      receptor

<220>
<221> SIGNAL         
<222> (1)...(22)

<400> 133
Met Ser Lys Gly Leu Leu Leu Leu Trp Leu Val Thr Glu Leu Trp Trp
        -20                 -15                 -10
Leu Tyr Leu Thr Pro Ala Ala Ser Glu Asp Thr Ile Ile Gly Phe Leu
    -5                   1               5                  10
Gly Gln Pro Val Thr Leu Pro Cys His Tyr Leu Ser Trp Ser Gln Ser
                15                  20                  25
Arg Asn Ser Met Cys Trp Gly Lys Gly Ser Cys Pro Asn Ser Lys Cys
            30                  35                  40
Asn Ala Glu Leu Leu Arg Thr Asp Gly Thr Arg Ile Ile Ser Arg Lys
        45                  50                  55
Ser Thr Lys Tyr Thr Leu Leu Gly Lys Val Gln Phe Gly Glu Val Ser
    60                  65                  70
Leu Thr Ile Ser Asn Thr Asn Arg Gly Asp Ser Gly Val Tyr Cys Cys
75                  80                  85                  90
Arg Ile Glu Val Pro Gly Trp Phe Asn Asp Val Lys Lys Asn Val Arg
                95                  100                 105
Leu Glu Leu Arg Arg Ala Thr Thr Thr Lys Lys Pro Thr Thr Thr Thr
            110                 115                 120
Arg Pro Thr Thr Thr Pro Tyr Val Thr Thr Thr Thr Pro Glu Leu Leu
        125                 130                 135
Pro Thr Thr Val Met Thr Thr Ser Val Leu Pro Thr Thr Thr Pro Pro
    140                 145                 150
Gln Thr Leu Ala Thr Thr Ala Phe Ser Thr Ala Val Thr Thr Cys Pro
155                 160                 165                 170
Ser Thr Thr Pro Gly Ser Phe Ser Gln Glu Thr Thr Lys Gly Ser Ala
                175                 180                 185
Phe Thr Thr Glu Ser Glu Thr Leu Pro Ala Ser Asn His Ser Gln Arg
            190                 195                 200
Ser Met Met Thr Ile Ser Thr Asp Ile Ala Val Leu Arg Pro Thr Gly
        205                 210                 215
Ser Asn Pro Gly Ile Leu Pro Ser Thr Ser Gln Leu Thr Thr Gln Lys
    220                 225                 230
Thr Thr Leu Thr Thr Ser Glu Ser Leu Gln Lys Thr Thr Lys Ser His
235                 240                 245                 250
Gln Ile Asn Ser Arg Gln Thr Ile Leu Ile Ile Ala Cys Cys Val Gly
                255                 260                 265
Phe Val Leu Met Val Leu Leu Phe Leu Ala Phe Leu Ala Leu Arg Arg
            270                 275                 280
Arg Val Gln Glu Thr Lys Phe Gly Gly Ala Phe Ser Glu Glu Asp Ser
        285                 290                 295
Gln Leu Val Val Asn Tyr Arg Ala Lys Lys Ser Phe Cys Arg Arg Ala
    300                 305                 310
Ile Glu Leu Thr Leu Gln Ser Leu Gly Val Ser Glu Glu Leu Gln Asn
315                 320                 325                 330
Lys Leu Glu Asp Val Val Ile Asp Arg Asn Leu Leu Val Leu Gly Lys
                335                 340                 345
Val Leu Gly Glu Gly Glu Phe Gly Ser Val Met Glu Gly Asn Leu Lys
            350                 355                 360
Gln Glu Asp Gly Thr Ser Gln Lys Val Ala Val Lys Thr Met Lys Leu
        365                 370                 375
Asp Asn Phe Ser Gln Arg Glu Ile Glu Glu Phe Leu Ser Glu Ala Ala
    380                 385                 390
Cys Met Lys Asp Phe Asn His Pro Asn Val Ile Arg Leu Leu Gly Val
395                 400                 405                 410
Cys Ile Glu Leu Ser Ser Gln Gly Ile Pro Lys Pro Met Val Ile Leu
                415                 420                 425
Pro Phe Met Lys Tyr Gly Asp Leu His Thr Phe Leu Leu Tyr Ser Arg
            430                 435                 440
Leu Asn Thr Gly Pro Lys Tyr Ile His Leu Gln Thr Leu Leu Lys Phe
        445                 450                 455
Met Met Asp Ile Ala Gln Gly Met Glu Tyr Leu Ser Asn Arg Asn Phe
    460                 465                 470
Leu His Arg Asp Leu Ala Ala Arg Asn Cys Met Leu Arg Asp Asp Met
475                 480                 485                 490
Thr Val Cys Val Ala Asp Phe Gly Leu Ser Lys Lys Ile Tyr Ser Gly
                495                 500                 505
Asp Tyr Tyr Arg Gln Gly Arg Ile Ala Lys Met Pro Val Lys Trp Ile
            510                 515                 520
Ala Ile Glu Ser Leu Ala Asp Arg Val Tyr Thr Ser Lys Ser Asp Val
        525                 530                 535
Trp Ala Phe Gly Val Thr Met Trp Glu Ile Thr Thr Arg Gly Met Thr
    540                 545                 550
Pro Tyr Pro Gly Val Gln Asn His Glu Met Tyr Asp Tyr Leu Leu His
555                 560                 565                 570
Gly His Arg Leu Lys Gln Pro Glu Asp Cys Leu Asp Glu Leu Tyr Asp
                575                 580                 585
Ile Met Tyr Ser Cys Trp Ser Ala Asp Pro Leu Asp Arg Pro Thr Phe
            590                 595                 600
Ser Val Leu Arg Leu Gln Leu Glu Lys Leu Ser Glu Ser Leu Pro Asp
        605                 610                 615
Ala Gln Asp Lys Glu Ser Ile Ile Tyr Ile Asn Thr Gln Leu Leu Glu
    620                 625                 630
Ser Cys Glu Gly Ile Ala Asn Gly Pro Ser Leu Thr Gly Leu Asp Met
635                 640                 645                 650
Asn Ile Asp Pro Asp Ser Ile Ile Ala Ser Cys Thr Pro Gly Ala Ala
                655                 660                 665
Val Ser Val Val Thr Ala Glu Val His Glu Asn Asn Leu Arg Glu Glu
            670                 675                 680
Arg Tyr Ile Leu Asn Gly Gly Asn Glu Glu Trp Glu Asp Val Ser Ser
        685                 690                 695
Thr Pro Phe Ala Ala Val Thr Pro Glu Lys Asp Gly Val Leu Pro Glu
    700                 705                 710
Asp Arg Leu Thr Lys Asn Gly Val Ser Trp Ser His His Ser Thr Leu
715                 720                 725                 730
Pro Leu Gly Ser Pro Ser Pro Asp Glu Leu Leu Phe Val Asp Asp Ser
                735                 740                 745
Leu Glu Asp Ser Glu Val Leu Met Met Ala Ala Gly Gly Pro Gly Ala
            750                 755                 760
Gly Ser Ala Ala Pro Val Ser Ser Thr Ser Ser Leu Pro Leu Ala Ala
        765                 770                 775
Leu Asn Met Arg Val Arg Arg Arg Leu Ser Leu Phe Leu Asn Val Arg
    780                 785                 790
Thr Gln Val Ala Ala Asp Trp Thr Ala Leu Ala Glu Glu Met Asp Phe
795                 800                 805                 810
Glu Tyr Leu Glu Ile Arg Gln Leu Glu Thr Gln Ala Asp Pro Thr Gly
                815                 820                 825
Arg Leu Leu Asp Ala Trp Gln Gly Arg Pro Gly Ala Ser Val Gly Arg
            830                 835                 840
Leu Leu Glu Leu Leu Thr Lys Leu Gly Arg Asp Asp Val Leu Leu Glu
        845                 850                 855
Leu Gly Pro Ser Ile Glu Glu Asp Cys Gln Lys Tyr Ile Leu Lys Gln
    860                 865                 870
Gln Gln Glu Glu Ala Glu Lys Pro Leu Gln Val Ala Ala Val Asp Ser
875                 880                 885                 890
Ser Val Pro Arg Thr Ala Glu Leu Ala Gly Ile Thr Thr Leu Asp Asp
                895                 900                 905
Pro Leu Gly


<210> 134
<211> 828
<212> PRT
<213> Artificial Sequence

<220> 
<223> TIM4-MERTK-DAP12 CER94 chimeric engulfment
      receptor

<220>
<221> SIGNAL         
<222> (1)...(22)

<400> 134
Met Ser Lys Gly Leu Leu Leu Leu Trp Leu Val Thr Glu Leu Trp Trp
        -20                 -15                 -10
Leu Tyr Leu Thr Pro Ala Ala Ser Glu Asp Thr Ile Ile Gly Phe Leu
    -5                   1               5                  10
Gly Gln Pro Val Thr Leu Pro Cys His Tyr Leu Ser Trp Ser Gln Ser
                15                  20                  25
Arg Asn Ser Met Cys Trp Gly Lys Gly Ser Cys Pro Asn Ser Lys Cys
            30                  35                  40
Asn Ala Glu Leu Leu Arg Thr Asp Gly Thr Arg Ile Ile Ser Arg Lys
        45                  50                  55
Ser Thr Lys Tyr Thr Leu Leu Gly Lys Val Gln Phe Gly Glu Val Ser
    60                  65                  70
Leu Thr Ile Ser Asn Thr Asn Arg Gly Asp Ser Gly Val Tyr Cys Cys
75                  80                  85                  90
Arg Ile Glu Val Pro Gly Trp Phe Asn Asp Val Lys Lys Asn Val Arg
                95                  100                 105
Leu Glu Leu Arg Arg Ala Thr Thr Thr Lys Lys Pro Thr Thr Thr Thr
            110                 115                 120
Arg Pro Thr Thr Thr Pro Tyr Val Thr Thr Thr Thr Pro Glu Leu Leu
        125                 130                 135
Pro Thr Thr Val Met Thr Thr Ser Val Leu Pro Thr Thr Thr Pro Pro
    140                 145                 150
Gln Thr Leu Ala Thr Thr Ala Phe Ser Thr Ala Val Thr Thr Cys Pro
155                 160                 165                 170
Ser Thr Thr Pro Gly Ser Phe Ser Gln Glu Thr Thr Lys Gly Ser Ala
                175                 180                 185
Phe Thr Thr Glu Ser Glu Thr Leu Pro Ala Ser Asn His Ser Gln Arg
            190                 195                 200
Ser Met Met Thr Ile Ser Thr Asp Ile Ala Val Leu Arg Pro Thr Gly
        205                 210                 215
Ser Asn Pro Gly Ile Leu Pro Ser Thr Ser Gln Leu Thr Thr Gln Lys
    220                 225                 230
Thr Thr Leu Thr Thr Ser Glu Ser Leu Gln Lys Thr Thr Lys Ser His
235                 240                 245                 250
Gln Ile Asn Ser Arg Gln Thr Ile Leu Ile Ile Ala Cys Cys Val Gly
                255                 260                 265
Phe Val Leu Met Val Leu Leu Phe Leu Ala Phe Leu Ala Leu Arg Arg
            270                 275                 280
Arg Val Gln Glu Thr Lys Phe Gly Gly Ala Phe Ser Glu Glu Asp Ser
        285                 290                 295
Gln Leu Val Val Asn Tyr Arg Ala Lys Lys Ser Phe Cys Arg Arg Ala
    300                 305                 310
Ile Glu Leu Thr Leu Gln Ser Leu Gly Val Ser Glu Glu Leu Gln Asn
315                 320                 325                 330
Lys Leu Glu Asp Val Val Ile Asp Arg Asn Leu Leu Val Leu Gly Lys
                335                 340                 345
Val Leu Gly Glu Gly Glu Phe Gly Ser Val Met Glu Gly Asn Leu Lys
            350                 355                 360
Gln Glu Asp Gly Thr Ser Gln Lys Val Ala Val Lys Thr Met Lys Leu
        365                 370                 375
Asp Asn Phe Ser Gln Arg Glu Ile Glu Glu Phe Leu Ser Glu Ala Ala
    380                 385                 390
Cys Met Lys Asp Phe Asn His Pro Asn Val Ile Arg Leu Leu Gly Val
395                 400                 405                 410
Cys Ile Glu Leu Ser Ser Gln Gly Ile Pro Lys Pro Met Val Ile Leu
                415                 420                 425
Pro Phe Met Lys Tyr Gly Asp Leu His Thr Phe Leu Leu Tyr Ser Arg
            430                 435                 440
Leu Asn Thr Gly Pro Lys Tyr Ile His Leu Gln Thr Leu Leu Lys Phe
        445                 450                 455
Met Met Asp Ile Ala Gln Gly Met Glu Tyr Leu Ser Asn Arg Asn Phe
    460                 465                 470
Leu His Arg Asp Leu Ala Ala Arg Asn Cys Met Leu Arg Asp Asp Met
475                 480                 485                 490
Thr Val Cys Val Ala Asp Phe Gly Leu Ser Lys Lys Ile Tyr Ser Gly
                495                 500                 505
Asp Tyr Tyr Arg Gln Gly Arg Ile Ala Lys Met Pro Val Lys Trp Ile
            510                 515                 520
Ala Ile Glu Ser Leu Ala Asp Arg Val Tyr Thr Ser Lys Ser Asp Val
        525                 530                 535
Trp Ala Phe Gly Val Thr Met Trp Glu Ile Thr Thr Arg Gly Met Thr
    540                 545                 550
Pro Tyr Pro Gly Val Gln Asn His Glu Met Tyr Asp Tyr Leu Leu His
555                 560                 565                 570
Gly His Arg Leu Lys Gln Pro Glu Asp Cys Leu Asp Glu Leu Tyr Asp
                575                 580                 585
Ile Met Tyr Ser Cys Trp Ser Ala Asp Pro Leu Asp Arg Pro Thr Phe
            590                 595                 600
Ser Val Leu Arg Leu Gln Leu Glu Lys Leu Ser Glu Ser Leu Pro Asp
        605                 610                 615
Ala Gln Asp Lys Glu Ser Ile Ile Tyr Ile Asn Thr Gln Leu Leu Glu
    620                 625                 630
Ser Cys Glu Gly Ile Ala Asn Gly Pro Ser Leu Thr Gly Leu Asp Met
635                 640                 645                 650
Asn Ile Asp Pro Asp Ser Ile Ile Ala Ser Cys Thr Pro Gly Ala Ala
                655                 660                 665
Val Ser Val Val Thr Ala Glu Val His Glu Asn Asn Leu Arg Glu Glu
            670                 675                 680
Arg Tyr Ile Leu Asn Gly Gly Asn Glu Glu Trp Glu Asp Val Ser Ser
        685                 690                 695
Thr Pro Phe Ala Ala Val Thr Pro Glu Lys Asp Gly Val Leu Pro Glu
    700                 705                 710
Asp Arg Leu Thr Lys Asn Gly Val Ser Trp Ser His His Ser Thr Leu
715                 720                 725                 730
Pro Leu Gly Ser Pro Ser Pro Asp Glu Leu Leu Phe Val Asp Asp Ser
                735                 740                 745
Leu Glu Asp Ser Glu Val Leu Met Tyr Phe Leu Gly Arg Leu Val Pro
            750                 755                 760
Arg Gly Arg Gly Ala Ala Glu Ala Ala Thr Arg Lys Gln Arg Ile Thr
        765                 770                 775
Glu Thr Glu Ser Pro Tyr Gln Glu Leu Gln Gly Gln Arg Ser Asp Val
    780                 785                 790
Tyr Ser Asp Leu Asn Thr Gln Arg Pro Tyr Tyr Lys
795                 800                 805

<210> 135
<211> 2754
<212> DNA
<213> Homo sapiens

<220> 
<223> BAI1 binding domain

<400> 135
gccgccggag cagacgcggg gcccgggccc gagccgtgcg ccacgctggt gcagggaaag      60
ttcttcggct acttctccgc ggccgccgtg ttcccggcca acgcctcgcg ctgctcctgg     120
acgctacgca acccggaccc gcggcgctac actctctaca tgaaggtggc caaggcgccc     180
gtgccctgca gcggccccgg ccgcgtgcgc acctaccagt tcgactcctt cctcgagtcc     240
acgcgcacct acctgggcgt ggagagcttc gacgaggtgc tgcggctctg cgacccctcc     300
gcacccctgg ccttcctgca ggccagcaag cagttcctgc agatgcggcg ccagcagccg     360
ccccagcacg acgggctccg gccccgggcc gggccgccgg gccccaccga cgacttctcc     420
gtggagtacc tggtggtggg gaaccgcaac cccagccgtg ccgcctgcca gatgctgtgc     480
cgctggctgg acgcgtgtct ggccggtagt cgcagctcgc acccctgcgg gatcatgcag     540
accccctgcg cctgcctggg cggcgaggcg ggcggccctg ccgcgggacc cctggccccc     600
cgcggggatg tctgcttgag agatgcggtg gctggtggcc ctgaaaactg cctcaccagc     660
ctgacccagg accggggcgg gcacggcgcc acaggcggct ggaagctgtg gtccctgtgg     720
ggcgaatgca cgcgggactg cgggggaggc ctccagacgc ggacgcgcac ctgcctgccc     780
gcgccgggcg tggagggcgg cggctgcgag ggggtgctgg aggagggtcg ccagtgcaac     840
cgcgaggcct gcggccccgc tgggcgcacc agctcccgga gccagtccct gcggtccaca     900
gatgcccggc ggcgcgagga gctgggggac gagctgcagc agtttgggtt cccagccccc     960
cagaccggtg acccagcagc cgaggagtgg tccccgtgga gcgtgtgctc cagcacctgc    1020
ggcgagggct ggcagacccg cacgcgcttc tgcgtgtcct cctcctacag cacgcagtgc    1080
agcggacccc tgcgcgagca gcggctgtgc aacaactctg ccgtgtgccc agtgcatggt    1140
gcctgggatg agtggtcgcc ctggagcctc tgctccagca cctgtggccg tggctttcgg    1200
gatcgcacgc gcacctgcag gcccccccag tttgggggca acccctgtga gggccctgag    1260
aagcaaacca agttctgcaa cattgccctg tgccctggcc gggcagtgga tggaaactgg    1320
aatgagtggt cgagctggag cgcctgctcc gccagctgct cccagggccg acagcagcgc    1380
acgcgtgaat gcaacgggcc ttcctacggg ggtgcggagt gccagggcca ctgggtggag    1440
acccgagact gcttcctgca gcagtgccca gtggatggca agtggcaggc ctgggcgtca    1500
tggggcagtt gcagcgtcac gtgtggggct ggcagccagc gacgggagcg tgtctgctct    1560
gggcccttct tcgggggagc agcctgccag ggcccccagg atgagtaccg gcagtgcggc    1620
acccagcggt gtcccgagcc ccatgagatc tgtgatgagg acaactttgg tgctgtgatc    1680
tggaaggaga ccccagcggg agaggtggct gctgtccggt gtccccgcaa cgccacagga    1740
ctcatcctgc gacggtgtga gctggacgag gaaggcatcg cctactggga gccccccacc    1800
tacatccgct gtgtttccat tgactacaga aacatccaga tgatgacccg ggagcacctg    1860
gccaaggctc agcgagggct gcctggggag ggggtctcgg aggtcatcca gacactggtg    1920
gagatctctc aggacgggac cagctacagt ggggacctgc tgtccaccat cgatgtcctg    1980
aggaacatga cagagatttt ccggagagcg tactacagcc ccacccctgg ggacgtacag    2040
aactttgtcc agatccttag caacctgttg gcagaggaga atcgggacaa gtgggaggag    2100
gcccagctgg cgggccccaa cgccaaggag ctgttccggc tggtggagga ctttgtggac    2160
gtcatcggct tccgcatgaa ggacctgagg gatgcatacc aggtgacaga caacctggtt    2220
ctcagcatcc ataagctccc agccagcgga gccactgaca tcagcttccc catgaagggc    2280
tggcgggcca cgggtgactg ggccaaggtg ccagaggaca gggtcactgt gtccaagagt    2340
gtcttctcca cggggctgac agaggccgat gaagcatccg tgtttgtggt gggcaccgtg    2400
ctctacagga acctgggcag cttcctggcc ctgcagagga acacgaccgt cctgaattct    2460
aaggtgatct ccgtgactgt gaaacccccg cctcgctccc tgcgcacacc cttggagatc    2520
gagtttgccc acatgtataa tggcaccacc aaccagacct gtatcctgtg ggatgagacg    2580
gatgtaccct cctcctccgc ccccccgcag ctcgggccct ggtcgtggcg cggctgccgc    2640
acggtgcccc tcgacgccct ccggacgcgc tgcctctgtg accggctctc caccttcgcc    2700
atcttagccc agctcagcgc cgacgcgaac atggagaagg cgactctgcc gtcg          2754

<210> 136
<211> 397
<212> PRT
<213> Homo sapiens

<220> 
<223> BAI1 signaling domain

<400> 136
Arg Arg Glu Val Gln Asp Ala Val Lys Cys Arg Val Val Asp Arg Gln
 1               5                  10                  15
Glu Glu Gly Asn Gly Asp Ser Gly Gly Ser Phe Gln Asn Gly His Ala
            20                  25                  30
Gln Leu Met Thr Asp Phe Glu Lys Asp Val Asp Leu Ala Cys Arg Ser
        35                  40                  45
Val Leu Asn Lys Asp Ile Ala Ala Cys Arg Thr Ala Thr Ile Thr Gly
    50                  55                  60
Thr Leu Lys Arg Pro Ser Leu Pro Glu Glu Glu Lys Leu Lys Leu Ala
65                  70                  75                  80
His Ala Lys Gly Pro Pro Thr Asn Phe Asn Ser Leu Pro Ala Asn Val
                85                  90                  95
Ser Lys Leu His Leu His Gly Ser Pro Arg Tyr Pro Gly Gly Pro Leu
            100                 105                 110
Pro Asp Phe Pro Asn His Ser Leu Thr Leu Lys Arg Asp Lys Ala Pro
        115                 120                 125
Lys Ser Ser Phe Val Gly Asp Gly Asp Ile Phe Lys Lys Leu Asp Ser
    130                 135                 140
Glu Leu Ser Arg Ala Gln Glu Lys Ala Leu Asp Thr Ser Tyr Val Ile
145                 150                 155                 160
Leu Pro Thr Ala Thr Ala Thr Leu Arg Pro Lys Pro Lys Glu Glu Pro
                165                 170                 175
Lys Tyr Ser Ile His Ile Asp Gln Met Pro Gln Thr Arg Leu Ile His
            180                 185                 190
Leu Ser Thr Ala Pro Glu Ala Ser Leu Pro Ala Arg Ser Pro Pro Ser
        195                 200                 205
Arg Gln Pro Pro Ser Gly Gly Pro Pro Glu Ala Pro Pro Ala Gln Pro
    210                 215                 220
Pro Pro Pro Pro Pro Pro Pro Pro Pro Pro Pro Gln Gln Pro Leu Pro
225                 230                 235                 240
Pro Pro Pro Asn Leu Glu Pro Ala Pro Pro Ser Leu Gly Asp Pro Gly
                245                 250                 255
Glu Pro Ala Ala His Pro Gly Pro Ser Thr Gly Pro Ser Thr Lys Asn
            260                 265                 270
Glu Asn Val Ala Thr Leu Ser Val Ser Ser Leu Glu Arg Arg Lys Ser
        275                 280                 285
Arg Tyr Ala Glu Leu Asp Phe Glu Lys Ile Met His Thr Arg Lys Arg
    290                 295                 300
His Gln Asp Met Phe Gln Asp Leu Asn Arg Lys Leu Gln His Ala Ala
305                 310                 315                 320
Glu Lys Asp Lys Glu Val Leu Gly Pro Asp Ser Lys Pro Glu Lys Gln
                325                 330                 335
Gln Thr Pro Asn Lys Arg Pro Trp Glu Ser Leu Arg Lys Ala His Gly
            340                 345                 350
Thr Pro Thr Trp Val Lys Lys Glu Leu Glu Pro Leu Gln Pro Ser Pro
        355                 360                 365
Leu Glu Leu Arg Ser Val Glu Trp Glu Arg Ser Gly Ala Thr Ile Pro
    370                 375                 380
Leu Val Gly Gln Asp Ile Ile Asp Leu Gln Thr Glu Val
385                 390                 395

<210> 137
<211> 171
<212> DNA
<213> Homo sapiens

<220> 
<223> ItgB5 signaling domain

<400> 137
aagctgcttg tcaccatcca cgaccggagg gagtttgcaa agtttcagag cgagcgatcc      60
agggcccgct atgaaatggc ttcaaatcca ttatacagaa agcctatctc cacgcacact     120
gtggacttca ccttcaacaa gttcaacaaa tcctacaatg gcactgtgga c              171

<210> 138
<211> 1419
<212> DNA
<213> Homo sapiens

<220> 
<223> MERTK signaling domain

<400> 138
aaaagagtcc aggagacaaa gtttgggaat gcattcacag aggaggattc tgaattagtg      60
gtgaattata tagcaaagaa atccttctgt cggcgagcca ttgaacttac cttacatagc     120
ttgggagtca gtgaggaact acaaaataaa ctagaagatg ttgtgattga caggaatctt     180
ctaattcttg gaaaaattct gggtgaagga gagtttgggt ctgtaatgga aggaaatctt     240
aagcaggaag atgggacctc tctgaaagtg gcagtgaaga ccatgaagtt ggacaactct     300
tcacagcggg agatcgagga gtttctcagt gaggcagcgt gcatgaaaga cttcagccac     360
ccaaatgtca ttcgacttct aggtgtgtgt atagaaatga gctctcaagg catcccaaag     420
cccatggtaa ttttaccctt catgaaatac ggggacctgc atacttactt actttattcc     480
cgattggaga caggaccaaa gcatattcct ctgcagacac tattgaagtt catggtggat     540
attgccctgg gaatggagta tctgagcaac aggaattttc ttcatcgaga tttagctgct     600
cgaaactgca tgttgcgaga tgacatgact gtctgtgttg cggacttcgg cctctctaag     660
aagatttaca gtggcgatta ttaccgccaa ggccgcattg ctaagatgcc tgttaaatgg     720
atcgccatag aaagtcttgc agaccgagtc tacacaagta aaagtgatgt gtgggcattt     780
ggcgtgacca tgtgggaaat agctacgcgg ggaatgactc cctatcctgg ggtccagaac     840
catgagatgt atgactatct tctccatggc cacaggttga agcagcccga agactgcctg     900
gatgaactgt atgaaataat gtactcttgc tggagaaccg atcccttaga ccgccccacc     960
ttttcagtat tgaggctgca gctagaaaaa ctcttagaaa gtttgcctga cgttcggaac    1020
caagcagacg ttatttacgt caatacacag ttgctggaga gctctgaggg cctggcccag    1080
ggctccaccc ttgctccact ggacttgaac atcgaccctg actctataat tgcctcctgc    1140
actccccgcg ctgccatcag tgtggtcaca gcagaagttc atgacagcaa acctcatgaa    1200
ggacggtaca tcctgaatgg gggcagtgag gaatgggaag atctgacttc tgccccctct    1260
gctgcagtca cagctgaaaa gaacagtgtt ttaccggggg agagacttgt taggaatggg    1320
gtctcctggt cccattcgag catgctgccc ttgggaagct cattgcccga tgaacttttg    1380
tttgctgacg actcctcaga aggctcagaa gtcctgatg                           1419

<210> 139
<211> 1191
<212> DNA
<213> Homo sapiens

<220> 
<223> BAI1 signaling domain

<400> 139
cgtagagagg tccaggacgc tgtgaaatgc cgtgtggttg accggcagga ggagggcaac      60
ggggactcag ggggctcctt ccagaacggc cacgcccagc tcatgaccga cttcgagaag     120
gacgtggatc tggcctgtag atcagtgctg aacaaggaca tcgcggcctg ccgcactgcc     180
accatcacgg gcacactgaa gcggccgtct ctgcccgagg aggagaagct gaagctggcc     240
catgccaagg ggccgcccac caatttcaac agcctgccgg ccaacgtgtc caagctgcac     300
ctgcacggct caccccgcta tcccggcggg cccctgcccg acttccccaa ccactcactg     360
accctcaaga gggacaaggc gcccaagtcc tccttcgtcg gtgacgggga catcttcaag     420
aagctggact cggagctgag ccgggcccag gagaaggctc tggacacgag ctacgtgatc     480
ctgcccacgg ccacggccac gctgcggccc aagcccaagg aggagcccaa gtacagcatc     540
cacattgacc agatgccgca gacccgcctc atccacctca gcacggcccc cgaggccagc     600
ctccccgccc gcagcccgcc ctcccgccag ccccccagcg gcgggccccc cgaggcaccc     660
cctgcccagc ccccaccgcc tccgccccca ccgccaccac ctccccagca gcccctgccc     720
ccaccgccca atctggagcc ggcacccccc agcctggggg atcccgggga gcctgccgcc     780
catccgggac ccagcacggg gcccagcacc aagaacgaga atgtcgccac cttgtctgtg     840
agctccctgg agcggcggaa gtcgcggtat gcagaactgg actttgagaa gatcatgcac     900
acccggaagc ggcaccaaga catgttccag gacctgaacc ggaagctgca gcacgcagcg     960
gagaaggaca aggaggtgct ggggccggac agcaagccgg aaaagcagca gacgcccaac    1020
aagaggccct gggagagcct ccggaaagcc cacgggacgc ccacgtgggt gaagaaggag    1080
ctggagccgc tgcagccgtc gccgctggag cttcgcagcg tggagtggga gaggtcgggc    1140
gccacgatcc cgctggtggg ccaggacatc atcgacctcc agaccgaggt c             1191

<210> 140
<211> 1191
<212> DNA
<213> Homo sapiens

<220> 
<223> ELMO

<400> 140
cgtagagagg tccaggacgc tgtgaaatgc cgtgtggttg accggcagga ggagggcaac      60
ggggactcag ggggctcctt ccagaacggc cacgcccagc tcatgaccga cttcgagaag     120
gacgtggatc tggcctgtag atcagtgctg aacaaggaca tcgcggcctg ccgcactgcc     180
accatcacgg gcacactgaa gcggccgtct ctgcccgagg aggagaagct gaagctggcc     240
catgccaagg ggccgcccac caatttcaac agcctgccgg ccaacgtgtc caagctgcac     300
ctgcacggct caccccgcta tcccggcggg cccctgcccg acttccccaa ccactcactg     360
accctcaaga gggacaaggc gcccaagtcc tccttcgtcg gtgacgggga catcttcaag     420
aagctggact cggagctgag ccgggcccag gagaaggctc tggacacgag ctacgtgatc     480
ctgcccacgg ccacggccac gctgcggccc aagcccaagg aggagcccaa gtacagcatc     540
cacattgacc agatgccgca gacccgcctc atccacctca gcacggcccc cgaggccagc     600
ctccccgccc gcagcccgcc ctcccgccag ccccccagcg gcgggccccc cgaggcaccc     660
cctgcccagc ccccaccgcc tccgccccca ccgccaccac ctccccagca gcccctgccc     720
ccaccgccca atctggagcc ggcacccccc agcctggggg atcccgggga gcctgccgcc     780
catccgggac ccagcacggg gcccagcacc aagaacgaga atgtcgccac cttgtctgtg     840
agctccctgg agcggcggaa gtcgcggtat gcagaactgg actttgagaa gatcatgcac     900
acccggaagc ggcaccaaga catgttccag gacctgaacc ggaagctgca gcacgcagcg     960
gagaaggaca aggaggtgct ggggccggac agcaagccgg aaaagcagca gacgcccaac    1020
aagaggccct gggagagcct ccggaaagcc cacgggacgc ccacgtgggt gaagaaggag    1080
ctggagccgc tgcagccgtc gccgctggag cttcgcagcg tggagtggga gaggtcgggc    1140
gccacgatcc cgctggtggg ccaggacatc atcgacctcc agaccgaggt c             1191

<210> 141
<211> 126
<212> DNA
<213> Homo sapiens

<220> 

<223> Fc(epsilon) RI(gamma) signaling domain

<400> 141
cgactgaaga tccaagtgcg aaaggcagct ataaccagct atgagaaatc agatggtgtt      60
tacacgggcc tgagcaccag gaaccaggag acttacgaga ctctgaagca tgagaaacca     120
ccacag                                                                126

<210> 142
<211> 21
<212> PRT
<213> Homo sapiens

<220> 
<223> BAI1 transmembrane domain

<400> 142
Val Thr Leu Ile Val Gly Cys Gly Val Ser Ser Leu Thr Leu Leu Met
 1               5                  10                  15
Leu Val Ile Ile Tyr
            20

<210> 143
<211> 63
<212> DNA
<213> Homo sapiens

<220> 
<223> BAI1 transmembrane domain

<400> 143
gtgacgctca tcgtgggctg tggcgtgtcc tctctcaccc tgctcatgct ggtcatcatc      60
tac                                                                    63

<210> 144
<211> 81
<212> DNA
<213> Homo sapiens

<220> 
<223> CD28 transmembrane domain

<400> 144
ttttgggtgc tggtggtggt tggtggagtc ctggcttgct atagcttgct agtaacagtg      60
gcctttatta ttttctgggt g                                                81

<210> 145
<211> 63
<212> DNA
<213> Homo sapiens

<220> 
<223> DAP12 transmembrane domain

<400> 145
ggcgtgctgg cagggatcgt gatgggagac ctggtgctga cagtgctcat tgccctggcc      60
gtg                                                                    63

<210> 146

<400>  146
000

<210> 147
<211> 18
<212> PRT
<213> Artificial Sequence

<220> 
<223> T2A self-cleaving peptide

<400> 147
Glu Gly Arg Gly Ser Leu Leu Thr Cys Gly Asp Val Glu Glu Asn Pro
 1               5                  10                  15
Gly Pro


<210> 148
<211> 20
<212> PRT
<213> Artificial Sequence

<220> 
<223> E2A self-cleaving peptide

<400> 148
Gln Cys Thr Asn Tyr Ala Leu Leu Lys Leu Ala Gly Asp Val Glu Ser
 1               5                  10                  15
Asn Pro Gly Pro
            20

<210> 149
<211> 22
<212> PRT
<213> Artificial Sequence

<220> 
<223> F2A self-cleaving peptide

<400> 149
Val Lys Gln Thr Leu Asn Phe Asp Leu Leu Lys Leu Ala Gly Asp Val
 1               5                  10                  15
Glu Ser Asn Pro Gly Pro
            20

<210> 150

<400> 150
000

<210> 151

<400> 151
000


<210> 152
<211> 774
<212> PRT
<213> Artificial Sequence

<220> 
<223> CER97 chimeric engulfment receptor

<220>
<221> SIGNAL         
<222> (1)...(22)

<400> 152
Met Ser Lys Gly Leu Leu Leu Leu Trp Leu Val Thr Glu Leu Trp Trp
        -20                 -15                 -10
Leu Tyr Leu Thr Pro Ala Ala Ser Glu Asp Thr Ile Ile Gly Phe Leu
    -5                   1               5                  10
Gly Gln Pro Val Thr Leu Pro Cys His Tyr Leu Ser Trp Ser Gln Ser
                15                  20                  25
Arg Asn Ser Met Cys Trp Gly Lys Gly Ser Cys Pro Asn Ser Lys Cys
            30                  35                  40
Asn Ala Glu Leu Leu Arg Thr Asp Gly Thr Arg Ile Ile Ser Arg Lys
        45                  50                  55
Ser Thr Lys Tyr Thr Leu Leu Gly Lys Val Gln Phe Gly Glu Val Ser
    60                  65                  70
Leu Thr Ile Ser Asn Thr Asn Arg Gly Asp Ser Gly Val Tyr Cys Cys
75                  80                  85                  90
Arg Ile Glu Val Pro Gly Trp Phe Asn Asp Val Lys Lys Asn Val Arg
                95                  100                 105
Leu Glu Leu Arg Arg Ala Thr Thr Thr Lys Lys Pro Thr Thr Thr Thr
            110                 115                 120
Arg Pro Thr Thr Thr Pro Tyr Val Thr Thr Thr Thr Pro Glu Leu Leu
        125                 130                 135
Pro Thr Thr Val Met Thr Thr Ser Val Leu Pro Thr Thr Thr Pro Pro
    140                 145                 150
Gln Thr Leu Ala Thr Thr Ala Phe Ser Thr Ala Val Thr Thr Cys Pro
155                 160                 165                 170
Ser Thr Thr Pro Gly Ser Phe Ser Gln Glu Thr Thr Lys Gly Ser Ala
                175                 180                 185
Phe Thr Thr Glu Ser Glu Thr Leu Pro Ala Ser Asn His Ser Gln Arg
            190                 195                 200
Ser Met Met Thr Ile Ser Thr Asp Ile Ala Val Leu Arg Pro Thr Gly
        205                 210                 215
Ser Asn Pro Gly Ile Leu Pro Ser Thr Ser Gln Leu Thr Thr Gln Lys
    220                 225                 230
Thr Thr Leu Thr Thr Ser Glu Ser Leu Gln Lys Thr Thr Lys Ser His
235                 240                 245                 250
Gln Ile Asn Ser Arg Gln Thr Ile Leu Ile Ile Ala Cys Cys Val Gly
                255                 260                 265
Phe Val Leu Met Val Leu Leu Phe Leu Ala Phe Leu His Arg Arg Lys
            270                 275                 280
Lys Glu Thr Arg Tyr Gly Glu Val Phe Glu Pro Thr Val Glu Arg Gly
        285                 290                 295
Glu Leu Val Val Arg Tyr Arg Val Arg Lys Ser Tyr Ser Arg Arg Thr
    300                 305                 310
Thr Glu Ala Thr Leu Asn Ser Leu Gly Ile Ser Glu Glu Leu Lys Glu
315                 320                 325                 330
Lys Leu Arg Asp Val Met Val Asp Arg His Lys Val Ala Leu Gly Lys
                335                 340                 345
Thr Leu Gly Glu Gly Glu Phe Gly Ala Val Met Glu Gly Gln Leu Asn
            350                 355                 360
Gln Asp Asp Ser Ile Leu Lys Val Ala Val Lys Thr Met Lys Ile Ala
        365                 370                 375
Ile Cys Thr Arg Ser Glu Leu Glu Asp Phe Leu Ser Glu Ala Val Cys
    380                 385                 390
Met Lys Glu Phe Asp His Pro Asn Val Met Arg Leu Ile Gly Val Cys
395                 400                 405                 410
Phe Gln Gly Ser Glu Arg Glu Ser Phe Pro Ala Pro Val Val Ile Leu
                415                 420                 425
Pro Phe Met Lys His Gly Asp Leu His Ser Phe Leu Leu Tyr Ser Arg
            430                 435                 440
Leu Gly Asp Gln Pro Val Tyr Leu Pro Thr Gln Met Leu Val Lys Phe
        445                 450                 455
Met Ala Asp Ile Ala Ser Gly Met Glu Tyr Leu Ser Thr Lys Arg Phe
    460                 465                 470
Ile His Arg Asp Leu Ala Ala Arg Asn Cys Met Leu Asn Glu Asn Met
475                 480                 485                 490
Ser Val Cys Val Ala Asp Phe Gly Leu Ser Lys Lys Ile Tyr Asn Gly
                495                 500                 505
Asp Tyr Tyr Arg Gln Gly Arg Ile Ala Lys Met Pro Val Lys Trp Ile
            510                 515                 520
Ala Ile Glu Ser Leu Ala Asp Arg Val Tyr Thr Ser Lys Ser Asp Val
        525                 530                 535
Trp Ser Phe Gly Val Thr Met Trp Glu Ile Ala Thr Arg Gly Gln Thr
    540                 545                 550
Pro Tyr Pro Gly Val Glu Asn Ser Glu Ile Tyr Asp Tyr Leu Arg Gln
555                 560                 565                 570
Gly Asn Arg Leu Lys Gln Pro Ala Asp Cys Leu Asp Gly Leu Tyr Ala
                575                 580                 585
Leu Met Ser Arg Cys Trp Glu Leu Asn Pro Gln Asp Arg Pro Ser Phe
            590                 595                 600
Thr Glu Leu Arg Glu Asp Leu Glu Asn Thr Leu Lys Ala Leu Pro Pro
        605                 610                 615
Ala Gln Glu Pro Asp Glu Ile Leu Tyr Val Asn Met Asp Glu Gly Gly
    620                 625                 630
Gly Tyr Pro Glu Pro Pro Gly Ala Ala Gly Gly Ala Asp Pro Pro Thr
635                 640                 645                 650
Gln Pro Asp Pro Lys Asp Ser Cys Ser Cys Leu Thr Ala Ala Glu Val
                655                 660                 665
His Pro Ala Gly Arg Tyr Val Leu Cys Pro Ser Thr Thr Pro Ser Pro
            670                 675                 680
Ala Gln Pro Ala Asp Arg Gly Ser Pro Ala Ala Pro Gly Gln Glu Asp
        685                 690                 695
Gly Ala Tyr Phe Leu Gly Arg Leu Val Pro Arg Gly Arg Gly Ala Ala
    700                 705                 710
Glu Ala Ala Thr Arg Lys Gln Arg Ile Thr Glu Thr Glu Ser Pro Tyr
715                 720                 725                 730
Gln Glu Leu Gln Gly Gln Arg Ser Asp Val Tyr Ser Asp Leu Asn Thr
                735                 740                 745
Gln Arg Pro Tyr Tyr Lys
            750

<210> 153
<211> 767
<212> PRT
<213> Artificial Sequence

<220> 
<223> CER98 chimeric engulfment receptor

<220>
<221> SIGNAL         
<222> (1)...(22)

<400> 153
Met Ser Lys Gly Leu Leu Leu Leu Trp Leu Val Thr Glu Leu Trp Trp
        -20                 -15                 -10
Leu Tyr Leu Thr Pro Ala Ala Ser Glu Asp Thr Ile Ile Gly Phe Leu
    -5                   1               5                  10
Gly Gln Pro Val Thr Leu Pro Cys His Tyr Leu Ser Trp Ser Gln Ser
                15                  20                  25
Arg Asn Ser Met Cys Trp Gly Lys Gly Ser Cys Pro Asn Ser Lys Cys
            30                  35                  40
Asn Ala Glu Leu Leu Arg Thr Asp Gly Thr Arg Ile Ile Ser Arg Lys
        45                  50                  55
Ser Thr Lys Tyr Thr Leu Leu Gly Lys Val Gln Phe Gly Glu Val Ser
    60                  65                  70
Leu Thr Ile Ser Asn Thr Asn Arg Gly Asp Ser Gly Val Tyr Cys Cys
75                  80                  85                  90
Arg Ile Glu Val Pro Gly Trp Phe Asn Asp Val Lys Lys Asn Val Arg
                95                  100                 105
Leu Glu Leu Arg Arg Ala Thr Thr Thr Lys Lys Pro Thr Thr Thr Thr
            110                 115                 120
Arg Pro Thr Thr Thr Pro Tyr Val Thr Thr Thr Thr Pro Glu Leu Leu
        125                 130                 135
Pro Thr Thr Val Met Thr Thr Ser Val Leu Pro Thr Thr Thr Pro Pro
    140                 145                 150
Gln Thr Leu Ala Thr Thr Ala Phe Ser Thr Ala Val Thr Thr Cys Pro
155                 160                 165                 170
Ser Thr Thr Pro Gly Ser Phe Ser Gln Glu Thr Thr Lys Gly Ser Ala
                175                 180                 185
Phe Thr Thr Glu Ser Glu Thr Leu Pro Ala Ser Asn His Ser Gln Arg
            190                 195                 200
Ser Met Met Thr Ile Ser Thr Asp Ile Ala Val Leu Arg Pro Thr Gly
        205                 210                 215
Ser Asn Pro Gly Ile Leu Pro Ser Thr Ser Gln Leu Thr Thr Gln Lys
    220                 225                 230
Thr Thr Leu Thr Thr Ser Glu Ser Leu Gln Lys Thr Thr Lys Ser His
235                 240                 245                 250
Gln Ile Asn Ser Arg Gln Thr Ile Leu Ile Ile Ala Cys Cys Val Gly
                255                 260                 265
Phe Val Leu Met Val Leu Leu Phe Leu Ala Phe Leu His Arg Arg Lys
            270                 275                 280
Lys Glu Thr Arg Tyr Gly Glu Val Phe Glu Pro Thr Val Glu Arg Gly
        285                 290                 295
Glu Leu Val Val Arg Tyr Arg Val Arg Lys Ser Tyr Ser Arg Arg Thr
    300                 305                 310
Thr Glu Ala Thr Leu Asn Ser Leu Gly Ile Ser Glu Glu Leu Lys Glu
315                 320                 325                 330
Lys Leu Arg Asp Val Met Val Asp Arg His Lys Val Ala Leu Gly Lys
                335                 340                 345
Thr Leu Gly Glu Gly Glu Phe Gly Ala Val Met Glu Gly Gln Leu Asn
            350                 355                 360
Gln Asp Asp Ser Ile Leu Lys Val Ala Val Lys Thr Met Lys Ile Ala
        365                 370                 375
Ile Cys Thr Arg Ser Glu Leu Glu Asp Phe Leu Ser Glu Ala Val Cys
    380                 385                 390
Met Lys Glu Phe Asp His Pro Asn Val Met Arg Leu Ile Gly Val Cys
395                 400                 405                 410
Phe Gln Gly Ser Glu Arg Glu Ser Phe Pro Ala Pro Val Val Ile Leu
                415                 420                 425
Pro Phe Met Lys His Gly Asp Leu His Ser Phe Leu Leu Tyr Ser Arg
            430                 435                 440
Leu Gly Asp Gln Pro Val Tyr Leu Pro Thr Gln Met Leu Val Lys Phe
        445                 450                 455
Met Ala Asp Ile Ala Ser Gly Met Glu Tyr Leu Ser Thr Lys Arg Phe
    460                 465                 470
Ile His Arg Asp Leu Ala Ala Arg Asn Cys Met Leu Asn Glu Asn Met
475                 480                 485                 490
Ser Val Cys Val Ala Asp Phe Gly Leu Ser Lys Lys Ile Tyr Asn Gly
                495                 500                 505
Asp Tyr Tyr Arg Gln Gly Arg Ile Ala Lys Met Pro Val Lys Trp Ile
            510                 515                 520
Ala Ile Glu Ser Leu Ala Asp Arg Val Tyr Thr Ser Lys Ser Asp Val
        525                 530                 535
Trp Ser Phe Gly Val Thr Met Trp Glu Ile Ala Thr Arg Gly Gln Thr
    540                 545                 550
Pro Tyr Pro Gly Val Glu Asn Ser Glu Ile Tyr Asp Tyr Leu Arg Gln
555                 560                 565                 570
Gly Asn Arg Leu Lys Gln Pro Ala Asp Cys Leu Asp Gly Leu Tyr Ala
                575                 580                 585
Leu Met Ser Arg Cys Trp Glu Leu Asn Pro Gln Asp Arg Pro Ser Phe
            590                 595                 600
Thr Glu Leu Arg Glu Asp Leu Glu Asn Thr Leu Lys Ala Leu Pro Pro
        605                 610                 615
Ala Gln Glu Pro Asp Glu Ile Leu Tyr Val Asn Met Asp Glu Gly Gly
    620                 625                 630
Gly Tyr Pro Glu Pro Pro Gly Ala Ala Gly Gly Ala Asp Pro Pro Thr
635                 640                 645                 650
Gln Pro Asp Pro Lys Asp Ser Cys Ser Cys Leu Thr Ala Ala Glu Val
                655                 660                 665
His Pro Ala Gly Arg Tyr Val Leu Cys Pro Ser Thr Thr Pro Ser Pro
            670                 675                 680
Ala Gln Pro Ala Asp Arg Gly Ser Pro Ala Ala Pro Gly Gln Glu Asp
        685                 690                 695
Gly Ala Asp Ser Lys Ala Gly Met Glu Glu Asp His Thr Tyr Glu Gly
    700                 705                 710
Leu Asp Ile Asp Gln Thr Ala Thr Tyr Glu Asp Ile Val Thr Leu Arg
715                 720                 725                 730
Thr Gly Glu Val Lys Trp Ser Val Gly Glu His Pro Gly Gln Glu
                735                 740                 745
